{"text_format":"2","workbook":"xls","n_sheets":3,"sheets":["general","CAL-B-UHP","m-CPBA"],"not_rendered":{"charts":3,"images":0,"macros":0,"external_links":1,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"general","index":0,"n_rows":9,"n_cols":14,"rows_kept":9,"cut":false,"hidden":false,"merged":[[5,3,5,5],[5,7,5,10],[5,12,5,14],[6,3,6,5],[6,12,6,14]],"flags":["formulas_cached_only"]}
["Environmental assessment of selective oxidation protocols"]
[]
["General remarks:"]
["The E-factor was calculated for non-volatiles, gases and volatile compounds constituting final products. Solvents were treated separately. Flash chromatography not included"]
[]
[null,null,null,"E-factor (excl. solvents)",null,null,null,"Waste classification (excl. solvents)",{"$nulls":4},"E-factor (incl. solvents)"]
["method","yield [%]","by-products [%]","reaction",null,null,null,"inorg. salts","organics","by-products","others",null,"reaction"]
["CAL-B-UHP",88,"<10",null,2,null,null,0,1.36,0.61,0.03,null,null,88.1]
["m-CPBA",96,"<4",null,4.68,null,null,1.78,0.01,2.79,0.1,null,null,304.6]

{"sheet":"CAL-B-UHP","index":1,"n_rows":24,"n_cols":8,"rows_kept":24,"cut":false,"hidden":false,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Chemoenzymatic oxidation"]
[]
[]
["oxime 2a"]
["yield:",0.88]
[]
[]
["Material","(Non)volatile [mg]","(Non)volatile [E]","Solvent [mL]",null,null,"E factor:"]
["Starting Materials",{"$nulls":5},"reaction",88.0828]
["benzylamine",53.5]
["hydrogen peroxide",34,0.001]
["urea",60,1.1267]
["CAL-B",12.5,0.2345]
[]
["Solvents"]
["water",null,18.7614,1]
["EtOAc",null,67.3159,4]
[]
["By-Products"]
["Water",null,0.4461]
["Benzaldehyde 3a",null,0.01]
["Benzonitrile 4a",null,0.0097]
["Imine 5a",null,0.1465]
["Others",null,0.031]

{"sheet":"m-CPBA","index":2,"n_rows":24,"n_cols":8,"rows_kept":24,"cut":false,"hidden":false,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Oxidation with m-CPBA"]
[]
[]
["oxime 2a","taken from V. V. Patil et al., J. Org. Chem. 2016, 81, 781-786"]
["yield:",0.96]
[]
[]
["Material","(Non)volatile [mg]","(Non)volatile [E]","Solvent [mL]",null,null,"E factor:"]
["Starting Materials",{"$nulls":5},"reaction",304.5880000000001]
["benzylamine",98.1]
["m-CPBA",320,0.0064]
[]
["Solvents"]
["water",null,92.1648,10]
["NaHCO3 sat. solution",null,27.6495,3]
["EtOAc",null,181.8781,22]
[]
["By-Products"]
["Water",null,0.1487]
["m-CBA",null,2.5849]
["Benzaldehyde 3a",null,0.0092]
["Benzonitrile 4a",null,0.0092]
["Imine 5a",null,0.0332]
["Others",null,0.104]