# Electronic Supplementary Material (ESI) for Chemical Communications.
# This journal is © The Royal Society of Chemistry 2018

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_cu_ZHAOYL180601_0m
_database_code_depnum_ccdc_archive 'CCDC 1846869'
_audit_update_record             
;
2018-06-02 deposited with the CCDC.
2018-07-03 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-2014
_chemical_name_systematic        
;
 ?
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C20 H23 N O4'
_chemical_formula_weight         341.39

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_H-M_alt        'P 21/n'
_space_group_name_Hall           '-P 2yn'

_shelx_space_group_comment       
;
The symmetry employed for this shelxl refinement is uniquely defined
by the following loop, which should always be used as a source of
symmetry information in preference to the above space-group names.
They are only intended as comments.
;

loop_
_space_group_symop_operation_xyz
'x, y, z'
'-x+1/2, y+1/2, -z+1/2'
'-x, -y, -z'
'x-1/2, -y-1/2, z-1/2'

_cell_length_a                   10.4449(13)
_cell_length_b                   8.4856(11)
_cell_length_c                   21.461(3)
_cell_angle_alpha                90
_cell_angle_beta                 99.489(5)
_cell_angle_gamma                90
_cell_volume                     1876.1(4)
_cell_formula_units_Z            4
_cell_measurement_temperature    295(2)
_cell_measurement_reflns_used    9795
_cell_measurement_theta_min      5.62
_cell_measurement_theta_max      72.07

_exptl_crystal_description       block
_exptl_crystal_colour            yellow
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    ?
_exptl_crystal_density_diffrn    1.209
_exptl_crystal_F_000             728
_exptl_transmission_factor_min   ?
_exptl_transmission_factor_max   ?
_exptl_crystal_size_max          0.21
_exptl_crystal_size_mid          0.19
_exptl_crystal_size_min          0.17
_exptl_absorpt_coefficient_mu    0.683
_shelx_estimated_absorpt_T_min   ?
_shelx_estimated_absorpt_T_max   ?
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_correction_T_min  0.866
_exptl_absorpt_correction_T_max  0.890
_exptl_absorpt_process_details   sadabs

_exptl_special_details           
;
 ?
;

_diffrn_ambient_temperature      295(2)
_diffrn_radiation_wavelength     1.54178
_diffrn_radiation_type           CuK\a
_diffrn_source                   ?
_diffrn_measurement_device_type  'CCD area detector'
_diffrn_measurement_method       'phi and omega scans'
_diffrn_detector_area_resol_mean ?
_diffrn_reflns_number            25276
_diffrn_reflns_av_unetI/netI     0.0785
_diffrn_reflns_av_R_equivalents  0.2051
_diffrn_reflns_limit_h_min       -12
_diffrn_reflns_limit_h_max       12
_diffrn_reflns_limit_k_min       -10
_diffrn_reflns_limit_k_max       9
_diffrn_reflns_limit_l_min       -26
_diffrn_reflns_limit_l_max       26
_diffrn_reflns_theta_min         5.617
_diffrn_reflns_theta_max         69.985
_diffrn_reflns_theta_full        67.679
_diffrn_measured_fraction_theta_max 0.994
_diffrn_measured_fraction_theta_full 0.994
_diffrn_reflns_Laue_measured_fraction_max 0.994
_diffrn_reflns_Laue_measured_fraction_full 0.994
_diffrn_reflns_point_group_measured_fraction_max 0.994
_diffrn_reflns_point_group_measured_fraction_full 0.994
_reflns_number_total             3550
_reflns_number_gt                2920
_reflns_threshold_expression     'I > 2σ(I)'
_reflns_Friedel_coverage         0.000
_reflns_Friedel_fraction_max     .
_reflns_Friedel_fraction_full    .

_reflns_special_details          
;
 Reflections were merged by SHELXL according to the crystal
 class for the calculation of statistics and refinement.
 
 _reflns_Friedel_fraction is defined as the number of unique
 Friedel pairs measured divided by the number that would be
 possible theoretically, ignoring centric projections and
 systematic absences.
;

_computing_data_collection       'Bruker SMART'
_computing_cell_refinement       'Bruker SMART'
_computing_data_reduction        'Bruker SAINT'
_computing_structure_solution    'Bruker SHELXTL'
_computing_structure_refinement  'SHELXL-2014 (Sheldrick, 2014)'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'

_refine_special_details          
;
 ?
;
_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'w=1/[σ²(Fo²)+(0.0763P)²+1.0402P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     ?
_atom_sites_solution_secondary   ?
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     SHELXL
_refine_ls_extinction_coef       0.029(2)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4^
_refine_ls_number_reflns         3550
_refine_ls_number_parameters     231
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0912
_refine_ls_R_factor_gt           0.0767
_refine_ls_wR_factor_ref         0.1942
_refine_ls_wR_factor_gt          0.1784
_refine_ls_goodness_of_fit_ref   1.005
_refine_ls_restrained_S_all      1.005
_refine_ls_shift/su_max          0.052
_refine_ls_shift/su_mean         0.001

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_site_symmetry_order
_atom_site_calc_flag
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
_atom_site_refinement_flags_occupancy
_atom_site_disorder_assembly
_atom_site_disorder_group
C1 C 0.30457(19) 0.2722(2) 0.32512(10) 0.0396(5) Uani 1 1 d . . . . .
C2 C 0.3744(2) 0.2684(3) 0.27686(10) 0.0415(5) Uani 1 1 d . . . . .
C3 C 0.3146(2) 0.2791(2) 0.21071(10) 0.0418(5) Uani 1 1 d . . . . .
C4 C 0.1762(2) 0.3078(3) 0.20069(9) 0.0411(5) Uani 1 1 d . . . . .
C5 C 0.1113(2) 0.3069(3) 0.25035(9) 0.0418(5) Uani 1 1 d . . . . .
H5 H 0.0217 0.3203 0.2425 0.050 Uiso 1 1 calc R U . . .
C6 C 0.0879(2) 0.2786(3) 0.35920(9) 0.0408(5) Uani 1 1 d . . . . .
C7 C 0.0364(2) 0.4145(3) 0.37941(12) 0.0565(6) Uani 1 1 d . . . . .
H7 H 0.0577 0.5123 0.3644 0.068 Uiso 1 1 calc R U . . .
C8 C -0.0486(3) 0.4028(3) 0.42285(13) 0.0682(8) Uani 1 1 d . . . . .
H8 H -0.0831 0.4946 0.4370 0.082 Uiso 1 1 calc R U . . .
C9 C -0.0830(3) 0.2611(3) 0.44549(12) 0.0605(7) Uani 1 1 d . . . . .
C10 C -0.0276(2) 0.1272(3) 0.42471(11) 0.0572(7) Uani 1 1 d . . . . .
H10 H -0.0484 0.0294 0.4399 0.069 Uiso 1 1 calc R U . . .
C11 C 0.0580(2) 0.1346(3) 0.38186(10) 0.0489(6) Uani 1 1 d . . . . .
H11 H 0.0947 0.0431 0.3687 0.059 Uiso 1 1 calc R U . . .
C12 C -0.1778(4) 0.2503(5) 0.49151(18) 0.0943(12) Uani 1 1 d . . . . .
H12A H -0.1321 0.2637 0.5338 0.141 Uiso 1 1 calc R U . . .
H12B H -0.2193 0.1490 0.4877 0.141 Uiso 1 1 calc R U . . .
H12C H -0.2422 0.3315 0.4823 0.141 Uiso 1 1 calc R U . . .
C13 C 0.5194(2) 0.2491(3) 0.28836(12) 0.0549(6) Uani 1 1 d . . . . .
C14 C 0.5996(2) 0.3832(4) 0.27061(15) 0.0719(8) Uani 1 1 d . . . . .
H14A H 0.5538 0.4323 0.2325 0.086 Uiso 1 1 calc R U . . .
H14B H 0.6086 0.4614 0.3040 0.086 Uiso 1 1 calc R U . . .
C15 C 0.7306(3) 0.3368(6) 0.2596(3) 0.1272(18) Uani 1 1 d . . . . .
H15A H 0.7744 0.2804 0.2957 0.191 Uiso 1 1 calc R U . . .
H15B H 0.7795 0.4294 0.2530 0.191 Uiso 1 1 calc R U . . .
H15C H 0.7231 0.2704 0.2230 0.191 Uiso 1 1 calc R U . . .
C16 C 0.1043(2) 0.3429(3) 0.13648(10) 0.0484(6) Uani 1 1 d . . . . .
C17 C -0.1021(3) 0.3428(5) 0.07193(14) 0.0831(10) Uani 1 1 d . . . . .
H17A H -0.1155 0.4560 0.0712 0.100 Uiso 1 1 calc R U . . .
H17B H -0.0609 0.3145 0.0362 0.100 Uiso 1 1 calc R U . . .
C18 C -0.2254(3) 0.2623(6) 0.0678(2) 0.1105(15) Uani 1 1 d . . . . .
H18A H -0.2119 0.1506 0.0664 0.166 Uiso 1 1 calc R U . . .
H18B H -0.2821 0.2951 0.0302 0.166 Uiso 1 1 calc R U . . .
H18C H -0.2641 0.2879 0.1041 0.166 Uiso 1 1 calc R U . . .
C19 C 0.3653(2) 0.2753(3) 0.39366(11) 0.0539(6) Uani 1 1 d . . . . .
H19A H 0.4468 0.2180 0.3993 0.065 Uiso 1 1 calc R U . . .
H19B H 0.3082 0.2235 0.4186 0.065 Uiso 1 1 calc R U . . .
C20 C 0.3898(4) 0.4436(4) 0.41654(13) 0.0851(10) Uani 1 1 d . . . . .
H20A H 0.4485 0.4937 0.3927 0.128 Uiso 1 1 calc R U . . .
H20B H 0.4271 0.4431 0.4605 0.128 Uiso 1 1 calc R U . . .
H20C H 0.3092 0.5003 0.4108 0.128 Uiso 1 1 calc R U . . .
N1 N 0.17112(16) 0.2872(2) 0.31125(7) 0.0402(5) Uani 1 1 d . . . . .
O1 O 0.37984(17) 0.2620(2) 0.16766(8) 0.0592(5) Uani 1 1 d . . . . .
O2 O 0.15002(19) 0.4056(3) 0.09515(8) 0.0709(6) Uani 1 1 d . . . . .
O3 O -0.01980(16) 0.2971(2) 0.13043(7) 0.0582(5) Uani 1 1 d . . . . .
O4 O 0.56811(19) 0.1300(3) 0.31207(13) 0.0937(8) Uani 1 1 d . . . . .


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes)
 are estimated using the full covariance matrix.  The cell esds are taken
 into account individually in the estimation of esds in distances, angles
 and torsion angles; correlations between esds in cell parameters are only
 used when they are defined by crystal symmetry.  An approximate (isotropic)
 treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
C1 C2 1.362(3) . ?
C1 N1 1.382(3) . ?
C1 C19 1.503(3) . ?
C2 C3 1.457(3) . ?
C2 C13 1.502(3) . ?
C3 O1 1.243(2) . ?
C3 C4 1.447(3) . ?
C4 C5 1.354(3) . ?
C4 C16 1.487(3) . ?
C5 N1 1.363(3) . ?
C5 H5 0.9300 . ?
C6 C7 1.373(3) . ?
C6 C11 1.370(3) . ?
C6 N1 1.454(2) . ?
C7 C8 1.393(3) . ?
C7 H7 0.9300 . ?
C8 C9 1.367(4) . ?
C8 H8 0.9300 . ?
C9 C10 1.381(4) . ?
C9 C12 1.512(3) . ?
C10 C11 1.386(3) . ?
C10 H10 0.9300 . ?
C11 H11 0.9300 . ?
C12 H12A 0.9600 . ?
C12 H12B 0.9600 . ?
C12 H12C 0.9600 . ?
C13 O4 1.205(3) . ?
C13 C14 1.499(4) . ?
C14 C15 1.480(4) . ?
C14 H14A 0.9700 . ?
C14 H14B 0.9700 . ?
C15 H15A 0.9600 . ?
C15 H15B 0.9600 . ?
C15 H15C 0.9600 . ?
C16 O2 1.199(3) . ?
C16 O3 1.339(3) . ?
C17 C18 1.448(5) . ?
C17 O3 1.452(3) . ?
C17 H17A 0.9700 . ?
C17 H17B 0.9700 . ?
C18 H18A 0.9600 . ?
C18 H18B 0.9600 . ?
C18 H18C 0.9600 . ?
C19 C20 1.518(4) . ?
C19 H19A 0.9700 . ?
C19 H19B 0.9700 . ?
C20 H20A 0.9600 . ?
C20 H20B 0.9600 . ?
C20 H20C 0.9600 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C2 C1 N1 119.09(18) . . ?
C2 C1 C19 123.50(19) . . ?
N1 C1 C19 117.19(18) . . ?
C1 C2 C3 122.83(19) . . ?
C1 C2 C13 122.0(2) . . ?
C3 C2 C13 115.19(18) . . ?
O1 C3 C4 124.4(2) . . ?
O1 C3 C2 121.2(2) . . ?
C4 C3 C2 114.39(17) . . ?
C5 C4 C3 119.99(19) . . ?
C5 C4 C16 119.25(19) . . ?
C3 C4 C16 120.73(18) . . ?
C4 C5 N1 123.06(19) . . ?
C4 C5 H5 118.5 . . ?
N1 C5 H5 118.5 . . ?
C7 C6 C11 120.86(19) . . ?
C7 C6 N1 119.48(19) . . ?
C11 C6 N1 119.62(18) . . ?
C6 C7 C8 118.5(2) . . ?
C6 C7 H7 120.7 . . ?
C8 C7 H7 120.7 . . ?
C9 C8 C7 122.3(2) . . ?
C9 C8 H8 118.8 . . ?
C7 C8 H8 118.8 . . ?
C8 C9 C10 117.4(2) . . ?
C8 C9 C12 121.6(3) . . ?
C10 C9 C12 121.0(3) . . ?
C11 C10 C9 121.8(2) . . ?
C11 C10 H10 119.1 . . ?
C9 C10 H10 119.1 . . ?
C6 C11 C10 119.1(2) . . ?
C6 C11 H11 120.5 . . ?
C10 C11 H11 120.5 . . ?
C9 C12 H12A 109.5 . . ?
C9 C12 H12B 109.5 . . ?
H12A C12 H12B 109.5 . . ?
C9 C12 H12C 109.5 . . ?
H12A C12 H12C 109.5 . . ?
H12B C12 H12C 109.5 . . ?
O4 C13 C2 120.3(2) . . ?
O4 C13 C14 121.9(2) . . ?
C2 C13 C14 117.8(2) . . ?
C15 C14 C13 114.1(3) . . ?
C15 C14 H14A 108.7 . . ?
C13 C14 H14A 108.7 . . ?
C15 C14 H14B 108.7 . . ?
C13 C14 H14B 108.7 . . ?
H14A C14 H14B 107.6 . . ?
C14 C15 H15A 109.5 . . ?
C14 C15 H15B 109.5 . . ?
H15A C15 H15B 109.5 . . ?
C14 C15 H15C 109.5 . . ?
H15A C15 H15C 109.5 . . ?
H15B C15 H15C 109.5 . . ?
O2 C16 O3 123.7(2) . . ?
O2 C16 C4 125.0(2) . . ?
O3 C16 C4 111.39(18) . . ?
C18 C17 O3 108.7(3) . . ?
C18 C17 H17A 110.0 . . ?
O3 C17 H17A 110.0 . . ?
C18 C17 H17B 110.0 . . ?
O3 C17 H17B 110.0 . . ?
H17A C17 H17B 108.3 . . ?
C17 C18 H18A 109.5 . . ?
C17 C18 H18B 109.5 . . ?
H18A C18 H18B 109.5 . . ?
C17 C18 H18C 109.5 . . ?
H18A C18 H18C 109.5 . . ?
H18B C18 H18C 109.5 . . ?
C1 C19 C20 110.8(2) . . ?
C1 C19 H19A 109.5 . . ?
C20 C19 H19A 109.5 . . ?
C1 C19 H19B 109.5 . . ?
C20 C19 H19B 109.5 . . ?
H19A C19 H19B 108.1 . . ?
C19 C20 H20A 109.5 . . ?
C19 C20 H20B 109.5 . . ?
H20A C20 H20B 109.5 . . ?
C19 C20 H20C 109.5 . . ?
H20A C20 H20C 109.5 . . ?
H20B C20 H20C 109.5 . . ?
C5 N1 C1 120.29(16) . . ?
C5 N1 C6 116.86(16) . . ?
C1 N1 C6 122.82(16) . . ?
C16 O3 C17 115.6(2) . . ?

_refine_diff_density_max         0.256
_refine_diff_density_min         -0.330
_refine_diff_density_rms         0.050

_shelxl_version_number           2014-3



