# Electronic Supplementary Material (ESI) for ChemComm.
# This journal is © The Royal Society of Chemistry 2019

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_1
_database_code_depnum_ccdc_archive 'CCDC 1539794'
_audit_update_record             
;
2017-03-23 deposited with the CCDC.
2019-01-09 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-2014/7
_shelx_SHELXL_version_number     2014/7
_chemical_name_systematic        ?
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C23 H35 N O'
_chemical_formula_weight         341.52

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_H-M_alt        'P 21/n'
_space_group_name_Hall           '-P 2yn'

_shelx_space_group_comment       
;
The symmetry employed for this shelxl refinement is uniquely defined
by the following loop, which should always be used as a source of
symmetry information in preference to the above space-group names.
They are only intended as comments.
;

loop_
_space_group_symop_operation_xyz
'x, y, z'
'-x+1/2, y+1/2, -z+1/2'
'-x, -y, -z'
'x-1/2, -y-1/2, z-1/2'

_cell_length_a                   9.383(3)
_cell_length_b                   20.549(7)
_cell_length_c                   11.175(4)
_cell_angle_alpha                90
_cell_angle_beta                 95.08(2)
_cell_angle_gamma                90
_cell_volume                     2146.2(13)
_cell_formula_units_Z            4
_cell_measurement_temperature    296(2)
_cell_measurement_reflns_used    4577
_cell_measurement_theta_min      2.39
_cell_measurement_theta_max      24.82

_exptl_crystal_description       block
_exptl_crystal_colour            colorless
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    ?
_exptl_crystal_density_diffrn    1.057
_exptl_crystal_F_000             752
_exptl_transmission_factor_min   ?
_exptl_transmission_factor_max   ?
_exptl_crystal_size_max          0.823
_exptl_crystal_size_mid          0.532
_exptl_crystal_size_min          0.247
_exptl_absorpt_coefficient_mu    0.063
_shelx_estimated_absorpt_T_min   0.950
_shelx_estimated_absorpt_T_max   0.985
_exptl_absorpt_correction_type   none
_exptl_absorpt_correction_T_min  ?
_exptl_absorpt_correction_T_max  ?
_exptl_absorpt_process_details   ?
_exptl_absorpt_special_details   ?
_diffrn_ambient_temperature      296(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_source                   ?
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       'φ and ω scans'
_diffrn_detector_area_resol_mean ?
_diffrn_reflns_number            11329
_diffrn_reflns_av_unetI/netI     0.0244
_diffrn_reflns_av_R_equivalents  0.0269
_diffrn_reflns_limit_h_min       -11
_diffrn_reflns_limit_h_max       11
_diffrn_reflns_limit_k_min       -17
_diffrn_reflns_limit_k_max       24
_diffrn_reflns_limit_l_min       -13
_diffrn_reflns_limit_l_max       13
_diffrn_reflns_theta_min         1.982
_diffrn_reflns_theta_max         24.831
_diffrn_reflns_theta_full        24.831
_diffrn_measured_fraction_theta_max 0.985
_diffrn_measured_fraction_theta_full 0.985
_diffrn_reflns_Laue_measured_fraction_max 0.985
_diffrn_reflns_Laue_measured_fraction_full 0.985
_diffrn_reflns_point_group_measured_fraction_max 0.985
_diffrn_reflns_point_group_measured_fraction_full 0.985
_reflns_number_total             3649
_reflns_number_gt                2833
_reflns_threshold_expression     'I > 2σ(I)'
_reflns_Friedel_coverage         0.000
_reflns_Friedel_fraction_max     .
_reflns_Friedel_fraction_full    .

_reflns_special_details          
;
 Reflections were merged by SHELXL according to the crystal
 class for the calculation of statistics and refinement.
 
 _reflns_Friedel_fraction is defined as the number of unique
 Friedel pairs measured divided by the number that would be
 possible theoretically, ignoring centric projections and
 systematic absences.
;

_computing_data_collection       ?
_computing_cell_refinement       ?
_computing_data_reduction        ?
_computing_structure_solution    ?
_computing_structure_refinement  'SHELXL-2014/7 (Sheldrick, 2014)'
_computing_molecular_graphics    ?
_computing_publication_material  ?
_refine_special_details          ?
_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'w=1/[σ²(Fo²)+(0.1051P)²+0.9615P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     ?
_atom_sites_solution_secondary   ?
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       .
_refine_ls_number_reflns         3649
_refine_ls_number_parameters     234
_refine_ls_number_restraints     55
_refine_ls_R_factor_all          0.0857
_refine_ls_R_factor_gt           0.0703
_refine_ls_wR_factor_ref         0.2156
_refine_ls_wR_factor_gt          0.1970
_refine_ls_goodness_of_fit_ref   1.072
_refine_ls_restrained_S_all      1.098
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_site_symmetry_order
_atom_site_calc_flag
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
_atom_site_refinement_flags_occupancy
_atom_site_disorder_assembly
_atom_site_disorder_group
N1 N 0.43286(17) 0.17048(9) 0.91268(15) 0.0443(5) Uani 1 1 d . . . . .
O1 O 0.3688(2) 0.23509(9) 0.74984(15) 0.0722(6) Uani 1 1 d . . . . .
C1 C 0.4293(2) 0.22756(11) 0.85094(19) 0.0478(6) Uani 1 1 d . . . . .
C2 C 0.5115(3) 0.27930(11) 0.9250(2) 0.0531(6) Uani 1 1 d . U . . .
C3 C 0.4165(4) 0.33973(15) 0.9303(3) 0.0875(10) Uani 1 1 d . . . . .
H3A H 0.3849 0.3535 0.8493 0.105 Uiso 1 1 calc R U . . .
H3B H 0.3323 0.3288 0.9707 0.105 Uiso 1 1 calc R U . . .
C4 C 0.4955(5) 0.39555(18) 0.9967(4) 0.1142(13) Uani 1 1 d . U . . .
H4A H 0.4327 0.4330 0.9978 0.137 Uiso 1 1 calc R U . . .
H4B H 0.5222 0.3828 1.0792 0.137 Uiso 1 1 calc R U . . .
C5 C 0.6261(5) 0.41368(17) 0.9383(3) 0.1042(12) Uani 1 1 d . U . . .
H5A H 0.6775 0.4474 0.9852 0.125 Uiso 1 1 calc R U . . .
H5B H 0.5985 0.4312 0.8590 0.125 Uiso 1 1 calc R U . . .
C6 C 0.7233(4) 0.35597(19) 0.9271(3) 0.1009(11) Uani 1 1 d . U . . .
H6A H 0.7623 0.3425 1.0065 0.121 Uiso 1 1 calc R U . . .
H6B H 0.8025 0.3686 0.8819 0.121 Uiso 1 1 calc R U . . .
C7 C 0.6438(3) 0.29861(15) 0.8640(3) 0.0737(8) Uani 1 1 d . U . . .
H7A H 0.6156 0.3103 0.7812 0.088 Uiso 1 1 calc R U . . .
H7B H 0.7079 0.2616 0.8636 0.088 Uiso 1 1 calc R U . . .
C8 C 0.5368(4) 0.24748(15) 1.0483(3) 0.0818(9) Uani 1 1 d . U . . .
H8A H 0.4683 0.2639 1.1011 0.098 Uiso 1 1 calc R U . . .
H8B H 0.6323 0.2575 1.0838 0.098 Uiso 1 1 calc R U . . .
C9 C 0.6580(3) 0.1367(2) 1.0322(3) 0.1035(12) Uani 1 1 d . U . . .
H9A H 0.6383 0.0913 1.0183 0.155 Uiso 1 1 calc R U . . .
H9B H 0.7124 0.1420 1.1084 0.155 Uiso 1 1 calc R U . . .
H9C H 0.7116 0.1533 0.9696 0.155 Uiso 1 1 calc R U . . .
C10 C 0.5192(2) 0.17345(12) 1.0325(2) 0.0536(6) Uani 1 1 d . U . . .
C11 C 0.4396(3) 0.14672(19) 1.1335(3) 0.0896(10) Uani 1 1 d . U . . .
H11A H 0.3564 0.1729 1.1423 0.134 Uiso 1 1 calc R U . . .
H11B H 0.5010 0.1476 1.2070 0.134 Uiso 1 1 calc R U . . .
H11C H 0.4110 0.1027 1.1155 0.134 Uiso 1 1 calc R U . . .
C12 C 0.6912(4) 0.0349(2) 0.7687(4) 0.1186(15) Uani 1 1 d . . . . .
H12A H 0.6979 0.0236 0.8524 0.178 Uiso 1 1 calc R U . . .
H12B H 0.7835 0.0482 0.7469 0.178 Uiso 1 1 calc R U . . .
H12C H 0.6592 -0.0023 0.7217 0.178 Uiso 1 1 calc R U . . .
C13 C 0.5707(4) 0.1115(3) 0.6122(4) 0.1223(15) Uani 1 1 d . . . . .
H13A H 0.6644 0.1190 0.5868 0.183 Uiso 1 1 calc R U . . .
H13B H 0.5153 0.1507 0.6025 0.183 Uiso 1 1 calc R U . . .
H13C H 0.5244 0.0775 0.5643 0.183 Uiso 1 1 calc R U . . .
C14 C 0.5836(3) 0.09114(16) 0.7450(3) 0.0747(8) Uani 1 1 d . . . . .
H14 H 0.6197 0.1286 0.7927 0.090 Uiso 1 1 calc R U . . .
C15 C 0.4373(3) 0.07407(12) 0.7835(2) 0.0600(7) Uani 1 1 d . . . . .
C16 C 0.3679(3) 0.01878(14) 0.7361(3) 0.0794(9) Uani 1 1 d . . . . .
H16 H 0.4151 -0.0085 0.6862 0.095 Uiso 1 1 calc R U . . .
C17 C 0.2313(3) 0.00361(15) 0.7611(3) 0.0849(10) Uani 1 1 d . . . . .
H17 H 0.1875 -0.0340 0.7297 0.102 Uiso 1 1 calc R U . . .
C18 C 0.1598(3) 0.04390(14) 0.8322(3) 0.0730(8) Uani 1 1 d . . . . .
H18 H 0.0664 0.0337 0.8471 0.088 Uiso 1 1 calc R U . . .
C19 C 0.2227(2) 0.09943(12) 0.8829(2) 0.0552(6) Uani 1 1 d . . . . .
C20 C 0.3649(2) 0.11324(11) 0.8605(2) 0.0484(6) Uani 1 1 d . . . . .
C21 C 0.0523(3) 0.1111(2) 1.0461(3) 0.0924(11) Uani 1 1 d . . . . .
H21A H -0.0146 0.0808 1.0071 0.139 Uiso 1 1 calc R U . . .
H21B H 0.0017 0.1427 1.0892 0.139 Uiso 1 1 calc R U . . .
H21C H 0.1186 0.0881 1.1012 0.139 Uiso 1 1 calc R U . . .
C22 C 0.1340(2) 0.14541(14) 0.9517(2) 0.0625(7) Uani 1 1 d . . . . .
H22 H 0.1998 0.1765 0.9940 0.075 Uiso 1 1 calc R U . . .
C23 C 0.0308(3) 0.18428(18) 0.8652(3) 0.0876(10) Uani 1 1 d . . . . .
H23A H 0.0843 0.2084 0.8108 0.131 Uiso 1 1 calc R U . . .
H23B H -0.0231 0.2138 0.9100 0.131 Uiso 1 1 calc R U . . .
H23C H -0.0333 0.1550 0.8205 0.131 Uiso 1 1 calc R U . . .


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes)
 are estimated using the full covariance matrix.  The cell esds are taken
 into account individually in the estimation of esds in distances, angles
 and torsion angles; correlations between esds in cell parameters are only
 used when they are defined by crystal symmetry.  An approximate (isotropic)
 treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
N1 C1 1.360(3) . ?
N1 C20 1.437(3) . ?
N1 C10 1.504(3) . ?
O1 C1 1.228(3) . ?
C1 C2 1.516(3) . ?
C2 C7 1.521(3) . ?
C2 C8 1.524(4) . ?
C2 C3 1.533(4) . ?
C3 C4 1.523(5) . ?
C4 C5 1.486(5) . ?
C5 C6 1.508(6) . ?
C6 C7 1.533(4) . ?
C8 C10 1.539(4) . ?
C9 C10 1.506(4) . ?
C10 C11 1.510(4) . ?
C12 C14 1.543(4) . ?
C13 C14 1.536(5) . ?
C14 C15 1.516(4) . ?
C15 C16 1.391(4) . ?
C15 C20 1.398(3) . ?
C16 C17 1.372(4) . ?
C17 C18 1.364(4) . ?
C18 C19 1.383(4) . ?
C19 C20 1.409(3) . ?
C19 C22 1.513(4) . ?
C21 C22 1.530(4) . ?
C22 C23 1.531(4) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C1 N1 C20 120.66(17) . . ?
C1 N1 C10 113.84(18) . . ?
C20 N1 C10 125.41(17) . . ?
O1 C1 N1 124.3(2) . . ?
O1 C1 C2 125.8(2) . . ?
N1 C1 C2 109.84(18) . . ?
C1 C2 C7 109.54(19) . . ?
C1 C2 C8 102.91(19) . . ?
C7 C2 C8 116.7(2) . . ?
C1 C2 C3 108.6(2) . . ?
C7 C2 C3 107.9(2) . . ?
C8 C2 C3 110.9(2) . . ?
C4 C3 C2 111.7(3) . . ?
C5 C4 C3 111.1(3) . . ?
C4 C5 C6 111.6(3) . . ?
C5 C6 C7 111.7(3) . . ?
C2 C7 C6 112.2(2) . . ?
C2 C8 C10 108.3(2) . . ?
N1 C10 C9 112.0(2) . . ?
N1 C10 C11 112.83(19) . . ?
C9 C10 C11 107.7(2) . . ?
N1 C10 C8 100.71(18) . . ?
C9 C10 C8 114.3(3) . . ?
C11 C10 C8 109.2(2) . . ?
C15 C14 C13 110.0(2) . . ?
C15 C14 C12 111.9(3) . . ?
C13 C14 C12 111.4(3) . . ?
C16 C15 C20 117.9(2) . . ?
C16 C15 C14 119.1(2) . . ?
C20 C15 C14 122.9(2) . . ?
C17 C16 C15 121.5(3) . . ?
C18 C17 C16 119.8(3) . . ?
C17 C18 C19 121.7(3) . . ?
C18 C19 C20 118.0(2) . . ?
C18 C19 C22 119.3(2) . . ?
C20 C19 C22 122.5(2) . . ?
C15 C20 C19 120.9(2) . . ?
C15 C20 N1 119.9(2) . . ?
C19 C20 N1 119.1(2) . . ?
C19 C22 C21 113.2(3) . . ?
C19 C22 C23 110.5(2) . . ?
C21 C22 C23 110.4(2) . . ?

_refine_diff_density_max         0.728
_refine_diff_density_min         -0.331
_refine_diff_density_rms         0.047

