File Name : figure s1.tif

Caption : <b>fig. s1</b>  full length of image of western blotting for figure 2c.

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Caption : <b>fig. s2</b>  tlc chromatograms of lipids in raw264.7 cell-derived exosomes and raw264.7 cells. lanes 1–5 contain lipids standard solution spotted in 0.2, 0.5, 1.0, 1.5 and 2.0 µg, respectively. lane 6 contain extracted sample from raw264.7 cells. lane 7 contain extracted sample from raw264.7 cell-derived exosomes.

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Caption : <b>fig. s3</b>  evaluation of chpnh<sub>2</sub> nanogel/cfse-raw-exosome hybrids formation by agarose gel (0.5%) electrophoresis with 40 mm tris-acetate buffer (ph7.4) at 50v for 30 min under cooling (approximately 10–15ºc), in the presence or absence of 6.7 mol % polyvinyl sulfate sodium salt (pvs) unit relative to the amino group moles of chpnh<sub>2</sub>. lane 1, 4: cfse-raw-exosome, lane 2, 5: chpnh<sub>2</sub> nanogel/cfse-raw-exosome hybrid (1wt:1wt), lane 3, 6: chpnh<sub>2</sub> nanogel/cfse-raw-exosome hybrid (2.5wt:1wt).

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Caption : <b>fig. s4</b>  the characterization of pc12-derived exosomes. (a) western blot analysis for cd81 (26 kda) protein in pc12-derived exosomes. (b) tem image of exosomes. (c) size distribution profile of exosomes determined by nta. (b) morphological observation by tem. scale bar represents 100 or 500 nm respectively.

File Name : table s1.tif

Caption : <b>table. s1</b>  the size and ζ-potential of chpnh<sub>2</sub> nanogel/raw264.7 cell-derived exosome hybrids.

File Name : table s2.tif

Caption : <b>table. s2</b>  the size and ζ-potential of chpnh<sub>2</sub> nanogel/pc12 cell-derived exosome hybrids.