# Electronic Supplementary Material (ESI) for ChemComm.
# This journal is © The Royal Society of Chemistry 2019

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_a
_audit_block_doi                 10.5517/ccdc.csd.cc229zky
_database_code_depnum_ccdc_archive 'CCDC 1916220'
loop_
_audit_author_name
_audit_author_address
wang
;chinese acdemy of sciences
China
;
_audit_update_record             
;
2019-05-15 deposited with the CCDC.	2019-06-19 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-2014/7
_shelx_SHELXL_version_number     2014/7
_chemical_name_systematic        ?
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C22 H18 Cl N O3'
_chemical_formula_weight         379.82

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_H-M_alt        'P 21/c'
_space_group_name_Hall           '-P 2ybc'

_shelx_space_group_comment       
;
The symmetry employed for this shelxl refinement is uniquely defined
by the following loop, which should always be used as a source of
symmetry information in preference to the above space-group names.
They are only intended as comments.
;

loop_
_space_group_symop_operation_xyz
'x, y, z'
'-x, y+1/2, -z+1/2'
'-x, -y, -z'
'x, -y-1/2, z-1/2'

_cell_length_a                   9.7422(7)
_cell_length_b                   8.7533(5)
_cell_length_c                   21.6004(14)
_cell_angle_alpha                90
_cell_angle_beta                 96.623(3)
_cell_angle_gamma                90
_cell_volume                     1829.7(2)
_cell_formula_units_Z            4
_cell_measurement_temperature    295(2)
_cell_measurement_reflns_used    7898
_cell_measurement_theta_min      2.51
_cell_measurement_theta_max      27.52

_exptl_crystal_description       block
_exptl_crystal_colour            colorless
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    ?
_exptl_crystal_density_diffrn    1.379
_exptl_crystal_F_000             792
_exptl_transmission_factor_min   ?
_exptl_transmission_factor_max   ?
_exptl_crystal_size_max          .32
_exptl_crystal_size_mid          .20
_exptl_crystal_size_min          .12
_exptl_absorpt_coefficient_mu    0.232
_shelx_estimated_absorpt_T_min   ?
_shelx_estimated_absorpt_T_max   ?
_exptl_absorpt_correction_type   empirical
_exptl_absorpt_process_details   'SADABS (Sheldrick, 1996)'
_exptl_absorpt_correction_T_min  .0000
_exptl_absorpt_correction_T_max  .0000
_exptl_absorpt_special_details   ?
_diffrn_ambient_temperature      295(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_source                   ?
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       'φ and ω scans'
_diffrn_detector_area_resol_mean ?
_diffrn_reflns_number            13175
_diffrn_reflns_av_unetI/netI     0.0288
_diffrn_reflns_av_R_equivalents  0.0284
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_h_max       12
_diffrn_reflns_limit_k_min       -11
_diffrn_reflns_limit_k_max       11
_diffrn_reflns_limit_l_min       -27
_diffrn_reflns_limit_l_max       28
_diffrn_reflns_theta_min         2.513
_diffrn_reflns_theta_max         27.519
_diffrn_reflns_theta_full        25.242
_diffrn_measured_fraction_theta_max 0.991
_diffrn_measured_fraction_theta_full 0.998
_diffrn_reflns_Laue_measured_fraction_max 0.991
_diffrn_reflns_Laue_measured_fraction_full 0.998
_diffrn_reflns_point_group_measured_fraction_max 0.991
_diffrn_reflns_point_group_measured_fraction_full 0.998
_reflns_number_total             4168
_reflns_number_gt                3694
_reflns_threshold_expression     'I > 2σ(I)'
_reflns_Friedel_coverage         0.000
_reflns_Friedel_fraction_max     .
_reflns_Friedel_fraction_full    .

_reflns_special_details          
;
 Reflections were merged by SHELXL according to the crystal
 class for the calculation of statistics and refinement.

 _reflns_Friedel_fraction is defined as the number of unique
 Friedel pairs measured divided by the number that would be
 possible theoretically, ignoring centric projections and
 systematic absences.
;

_computing_data_collection       'Siemens SMART'
_computing_cell_refinement       'Siemens SMART & SAINT'
_computing_data_reduction        'Siemens XPREP'
_computing_structure_solution    'Siemens SHELXTL'
_computing_structure_refinement  "S'Siemens SHELXTL"
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'
_refine_special_details          ?
_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'w=1/[σ²(Fo²)+(0.0641P)²+0.6389P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     ?
_atom_sites_solution_secondary   ?
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       .
_refine_ls_number_reflns         4168
_refine_ls_number_parameters     244
_refine_ls_number_restraints     0
_refine_ls_R_factor_ref          0.0474
_refine_ls_R_factor_gt           0.0431
_refine_ls_wR_factor_ref         0.1281
_refine_ls_wR_factor_gt          0.1247
_refine_ls_goodness_of_fit_ref   1.031
_refine_ls_restrained_S_all      1.031
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_site_symmetry_order
_atom_site_calc_flag
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
_atom_site_refinement_flags_occupancy
_atom_site_disorder_assembly
_atom_site_disorder_group
Cl1 Cl 0.03499(7) 0.22824(7) 0.45476(3) 0.0781(2) Uani 1 1 d . . . . .
O1 O 0.25005(14) -0.11213(15) 0.16231(6) 0.0609(3) Uani 1 1 d . . . . .
O2 O 0.40023(14) -0.58172(14) 0.41484(5) 0.0561(3) Uani 1 1 d . . . . .
O3 O 0.25656(14) -0.39458(15) 0.43499(5) 0.0582(3) Uani 1 1 d . . . . .
N1 N 0.33649(12) -0.50838(13) 0.28289(5) 0.0352(3) Uani 1 1 d . . . . .
C1 C 0.40130(16) -0.66072(17) 0.28394(7) 0.0428(3) Uani 1 1 d . . . . .
H1A H 0.3859 -0.7143 0.3218 0.051 Uiso 1 1 calc R U . . .
H1B H 0.5001 -0.6507 0.2828 0.051 Uiso 1 1 calc R U . . .
C2 C 0.33767(18) -0.74900(17) 0.22762(8) 0.0452(4) Uani 1 1 d . . . . .
H2A H 0.3844 -0.8464 0.2256 0.054 Uiso 1 1 calc R U . . .
H2B H 0.2411 -0.7689 0.2315 0.054 Uiso 1 1 calc R U . . .
C3 C 0.34929(15) -0.66037(17) 0.16875(7) 0.0399(3) Uani 1 1 d . . . . .
C4 C 0.37149(18) -0.7329(2) 0.11359(8) 0.0501(4) Uani 1 1 d . . . . .
H4A H 0.3789 -0.8388 0.1126 0.060 Uiso 1 1 calc R U . . .
C5 C 0.38274(19) -0.6495(2) 0.06012(8) 0.0564(4) Uani 1 1 d . . . . .
H5A H 0.3957 -0.6993 0.0232 0.068 Uiso 1 1 calc R U . . .
C6 C 0.37473(19) -0.4921(2) 0.06151(8) 0.0539(4) Uani 1 1 d . . . . .
H6A H 0.3836 -0.4360 0.0256 0.065 Uiso 1 1 calc R U . . .
C7 C 0.35355(16) -0.41704(19) 0.11614(7) 0.0440(3) Uani 1 1 d . . . . .
H7A H 0.3500 -0.3109 0.1169 0.053 Uiso 1 1 calc R U . . .
C8 C 0.33753(13) -0.49990(17) 0.17010(7) 0.0364(3) Uani 1 1 d . . . . .
C9 C 0.30662(13) -0.42824(15) 0.22876(6) 0.0343(3) Uani 1 1 d . . . . .
C10 C 0.29360(14) -0.42791(16) 0.33223(6) 0.0355(3) Uani 1 1 d . . . . .
C11 C 0.23115(13) -0.29404(16) 0.30850(7) 0.0351(3) Uani 1 1 d . . . . .
C12 C 0.23992(14) -0.29284(16) 0.24342(6) 0.0349(3) Uani 1 1 d . . . . .
C13 C 0.18352(16) -0.16904(17) 0.20039(7) 0.0418(3) Uani 1 1 d . . . . .
C14 C 0.0385(2) -0.1155(3) 0.20520(9) 0.0650(5) Uani 1 1 d . . . . .
H14A H 0.0006 -0.1717 0.2374 0.097 Uiso 1 1 calc R U . . .
H14B H 0.0396 -0.0086 0.2151 0.097 Uiso 1 1 calc R U . . .
H14C H -0.0172 -0.1320 0.1661 0.097 Uiso 1 1 calc R U . . .
C15 C 0.32397(15) -0.47847(17) 0.39708(7) 0.0391(3) Uani 1 1 d . . . . .
C16 C 0.2812(2) -0.4290(2) 0.50055(8) 0.0629(5) Uani 1 1 d . . . . .
H16A H 0.2273 -0.3616 0.5232 0.094 Uiso 1 1 calc R U . . .
H16B H 0.2552 -0.5329 0.5074 0.094 Uiso 1 1 calc R U . . .
H16C H 0.3775 -0.4155 0.5147 0.094 Uiso 1 1 calc R U . . .
C17 C 0.05196(16) -0.1716(2) 0.36750(8) 0.0485(4) Uani 1 1 d . . . . .
H17A H -0.0040 -0.2571 0.3598 0.058 Uiso 1 1 calc R U . . .
C18 C 0.00657(17) -0.0506(2) 0.40114(8) 0.0529(4) Uani 1 1 d . . . . .
H18A H -0.0795 -0.0542 0.4158 0.064 Uiso 1 1 calc R U . . .
C19 C 0.09070(18) 0.07507(19) 0.41260(7) 0.0486(4) Uani 1 1 d . . . . .
C20 C 0.2193(2) 0.08196(19) 0.39209(8) 0.0519(4) Uani 1 1 d . . . . .
H20A H 0.2759 0.1664 0.4011 0.062 Uiso 1 1 calc R U . . .
C21 C 0.26279(16) -0.03872(18) 0.35786(7) 0.0442(3) Uani 1 1 d . . . . .
H21A H 0.3487 -0.0340 0.3432 0.053 Uiso 1 1 calc R U . . .
C22 C 0.18024(14) -0.16674(16) 0.34510(6) 0.0362(3) Uani 1 1 d . . . . .


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes)
 are estimated using the full covariance matrix.  The cell esds are taken
 into account individually in the estimation of esds in distances, angles
 and torsion angles; correlations between esds in cell parameters are only
 used when they are defined by crystal symmetry.  An approximate (isotropic)
 treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
Cl1 C19 1.7423(16) . ?
O1 C13 1.212(2) . ?
O2 C15 1.2042(18) . ?
O3 C15 1.3286(19) . ?
O3 C16 1.4408(19) . ?
N1 C9 1.3658(18) . ?
N1 C10 1.3817(17) . ?
N1 C1 1.4745(18) . ?
C1 C2 1.512(2) . ?
C1 H1A 0.9700 . ?
C1 H1B 0.9700 . ?
C2 C3 1.505(2) . ?
C2 H2A 0.9700 . ?
C2 H2B 0.9700 . ?
C3 C4 1.389(2) . ?
C3 C8 1.410(2) . ?
C4 C5 1.381(3) . ?
C4 H4A 0.9300 . ?
C5 C6 1.381(3) . ?
C5 H5A 0.9300 . ?
C6 C7 1.386(2) . ?
C6 H6A 0.9300 . ?
C7 C8 1.397(2) . ?
C7 H7A 0.9300 . ?
C8 C9 1.4756(19) . ?
C9 C12 1.4052(19) . ?
C10 C11 1.3907(19) . ?
C10 C15 1.466(2) . ?
C11 C12 1.418(2) . ?
C11 C22 1.4842(19) . ?
C12 C13 1.491(2) . ?
C13 C14 1.503(2) . ?
C14 H14A 0.9600 . ?
C14 H14B 0.9600 . ?
C14 H14C 0.9600 . ?
C16 H16A 0.9600 . ?
C16 H16B 0.9600 . ?
C16 H16C 0.9600 . ?
C17 C18 1.385(2) . ?
C17 C22 1.392(2) . ?
C17 H17A 0.9300 . ?
C18 C19 1.377(3) . ?
C18 H18A 0.9300 . ?
C19 C20 1.377(2) . ?
C20 C21 1.384(2) . ?
C20 H20A 0.9300 . ?
C21 C22 1.388(2) . ?
C21 H21A 0.9300 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C15 O3 C16 116.88(13) . . ?
C9 N1 C10 110.18(11) . . ?
C9 N1 C1 121.75(12) . . ?
C10 N1 C1 128.04(12) . . ?
N1 C1 C2 108.34(12) . . ?
N1 C1 H1A 110.0 . . ?
C2 C1 H1A 110.0 . . ?
N1 C1 H1B 110.0 . . ?
C2 C1 H1B 110.0 . . ?
H1A C1 H1B 108.4 . . ?
C3 C2 C1 110.64(13) . . ?
C3 C2 H2A 109.5 . . ?
C1 C2 H2A 109.5 . . ?
C3 C2 H2B 109.5 . . ?
C1 C2 H2B 109.5 . . ?
H2A C2 H2B 108.1 . . ?
C4 C3 C8 119.62(15) . . ?
C4 C3 C2 121.58(14) . . ?
C8 C3 C2 118.80(13) . . ?
C5 C4 C3 120.72(16) . . ?
C5 C4 H4A 119.6 . . ?
C3 C4 H4A 119.6 . . ?
C6 C5 C4 119.95(15) . . ?
C6 C5 H5A 120.0 . . ?
C4 C5 H5A 120.0 . . ?
C5 C6 C7 120.37(16) . . ?
C5 C6 H6A 119.8 . . ?
C7 C6 H6A 119.8 . . ?
C6 C7 C8 120.41(16) . . ?
C6 C7 H7A 119.8 . . ?
C8 C7 H7A 119.8 . . ?
C7 C8 C3 118.87(13) . . ?
C7 C8 C9 123.32(13) . . ?
C3 C8 C9 117.80(13) . . ?
N1 C9 C12 107.38(12) . . ?
N1 C9 C8 118.18(12) . . ?
C12 C9 C8 134.23(13) . . ?
N1 C10 C11 107.68(12) . . ?
N1 C10 C15 122.50(12) . . ?
C11 C10 C15 129.64(13) . . ?
C10 C11 C12 107.32(12) . . ?
C10 C11 C22 126.52(13) . . ?
C12 C11 C22 125.76(12) . . ?
C9 C12 C11 107.42(12) . . ?
C9 C12 C13 128.27(13) . . ?
C11 C12 C13 124.29(12) . . ?
O1 C13 C12 122.32(14) . . ?
O1 C13 C14 119.96(15) . . ?
C12 C13 C14 117.73(14) . . ?
C13 C14 H14A 109.5 . . ?
C13 C14 H14B 109.5 . . ?
H14A C14 H14B 109.5 . . ?
C13 C14 H14C 109.5 . . ?
H14A C14 H14C 109.5 . . ?
H14B C14 H14C 109.5 . . ?
O2 C15 O3 123.30(14) . . ?
O2 C15 C10 125.46(14) . . ?
O3 C15 C10 111.24(12) . . ?
O3 C16 H16A 109.5 . . ?
O3 C16 H16B 109.5 . . ?
H16A C16 H16B 109.5 . . ?
O3 C16 H16C 109.5 . . ?
H16A C16 H16C 109.5 . . ?
H16B C16 H16C 109.5 . . ?
C18 C17 C22 120.86(16) . . ?
C18 C17 H17A 119.6 . . ?
C22 C17 H17A 119.6 . . ?
C19 C18 C17 119.05(15) . . ?
C19 C18 H18A 120.5 . . ?
C17 C18 H18A 120.5 . . ?
C18 C19 C20 121.44(15) . . ?
C18 C19 Cl1 119.59(13) . . ?
C20 C19 Cl1 118.96(14) . . ?
C19 C20 C21 118.99(16) . . ?
C19 C20 H20A 120.5 . . ?
C21 C20 H20A 120.5 . . ?
C20 C21 C22 121.07(14) . . ?
C20 C21 H21A 119.5 . . ?
C22 C21 H21A 119.5 . . ?
C21 C22 C17 118.57(14) . . ?
C21 C22 C11 119.36(13) . . ?
C17 C22 C11 122.07(13) . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C9 N1 C1 C2 -39.94(18) . . . . ?
C10 N1 C1 C2 137.89(14) . . . . ?
N1 C1 C2 C3 54.47(17) . . . . ?
C1 C2 C3 C4 144.50(15) . . . . ?
C1 C2 C3 C8 -35.35(19) . . . . ?
C8 C3 C4 C5 0.3(2) . . . . ?
C2 C3 C4 C5 -179.58(16) . . . . ?
C3 C4 C5 C6 1.3(3) . . . . ?
C4 C5 C6 C7 -0.9(3) . . . . ?
C5 C6 C7 C8 -1.2(3) . . . . ?
C6 C7 C8 C3 2.7(2) . . . . ?
C6 C7 C8 C9 -176.31(14) . . . . ?
C4 C3 C8 C7 -2.3(2) . . . . ?
C2 C3 C8 C7 177.58(13) . . . . ?
C4 C3 C8 C9 176.82(13) . . . . ?
C2 C3 C8 C9 -3.3(2) . . . . ?
C10 N1 C9 C12 -1.11(15) . . . . ?
C1 N1 C9 C12 177.07(12) . . . . ?
C10 N1 C9 C8 -176.55(11) . . . . ?
C1 N1 C9 C8 1.63(19) . . . . ?
C7 C8 C9 N1 -159.16(13) . . . . ?
C3 C8 C9 N1 21.78(18) . . . . ?
C7 C8 C9 C12 26.9(2) . . . . ?
C3 C8 C9 C12 -152.14(15) . . . . ?
C9 N1 C10 C11 1.58(15) . . . . ?
C1 N1 C10 C11 -176.46(13) . . . . ?
C9 N1 C10 C15 -173.89(12) . . . . ?
C1 N1 C10 C15 8.1(2) . . . . ?
N1 C10 C11 C12 -1.39(15) . . . . ?
C15 C10 C11 C12 173.64(14) . . . . ?
N1 C10 C11 C22 -174.49(13) . . . . ?
C15 C10 C11 C22 0.5(2) . . . . ?
N1 C9 C12 C11 0.22(15) . . . . ?
C8 C9 C12 C11 174.61(14) . . . . ?
N1 C9 C12 C13 -178.32(13) . . . . ?
C8 C9 C12 C13 -3.9(3) . . . . ?
C10 C11 C12 C9 0.73(15) . . . . ?
C22 C11 C12 C9 173.90(13) . . . . ?
C10 C11 C12 C13 179.34(13) . . . . ?
C22 C11 C12 C13 -7.5(2) . . . . ?
C9 C12 C13 O1 -49.1(2) . . . . ?
C11 C12 C13 O1 132.64(17) . . . . ?
C9 C12 C13 C14 130.68(17) . . . . ?
C11 C12 C13 C14 -47.6(2) . . . . ?
C16 O3 C15 O2 1.8(3) . . . . ?
C16 O3 C15 C10 -177.86(15) . . . . ?
N1 C10 C15 O2 8.9(2) . . . . ?
C11 C10 C15 O2 -165.51(16) . . . . ?
N1 C10 C15 O3 -171.48(13) . . . . ?
C11 C10 C15 O3 14.1(2) . . . . ?
C22 C17 C18 C19 -0.4(3) . . . . ?
C17 C18 C19 C20 -0.9(3) . . . . ?
C17 C18 C19 Cl1 179.92(13) . . . . ?
C18 C19 C20 C21 1.7(3) . . . . ?
Cl1 C19 C20 C21 -179.12(14) . . . . ?
C19 C20 C21 C22 -1.2(3) . . . . ?
C20 C21 C22 C17 0.0(2) . . . . ?
C20 C21 C22 C11 -179.68(15) . . . . ?
C18 C17 C22 C21 0.8(2) . . . . ?
C18 C17 C22 C11 -179.51(15) . . . . ?
C10 C11 C22 C21 97.91(18) . . . . ?
C12 C11 C22 C21 -73.97(19) . . . . ?
C10 C11 C22 C17 -81.8(2) . . . . ?
C12 C11 C22 C17 106.35(18) . . . . ?

_refine_diff_density_max         0.271
_refine_diff_density_min         -0.285
_refine_diff_density_rms         0.062


