# Electronic Supplementary Material (ESI) for ChemComm.
# This journal is © The Royal Society of Chemistry 2019

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_SUST_1437_0m
_database_code_depnum_ccdc_archive 'CCDC 1962679'
loop_
_audit_author_name
_audit_author_address
imide
;Shaanxi University of Science and Technology
China
;
_audit_update_record             
;
2019-10-31 deposited with the CCDC.	2019-12-11 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-2014/7
_shelx_SHELXL_version_number     2014/7
_chemical_name_systematic        ?
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C21 H25 N O3'
_chemical_formula_weight         339.42

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_H-M_alt        'P 21/c'
_space_group_name_Hall           '-P 2ybc'

_shelx_space_group_comment       
;
The symmetry employed for this shelxl refinement is uniquely defined
by the following loop, which should always be used as a source of
symmetry information in preference to the above space-group names.
They are only intended as comments.
;

loop_
_space_group_symop_operation_xyz
'x, y, z'
'-x, y+1/2, -z+1/2'
'-x, -y, -z'
'x, -y-1/2, z-1/2'

_cell_length_a                   8.746(8)
_cell_length_b                   10.239(10)
_cell_length_c                   21.43(2)
_cell_angle_alpha                90
_cell_angle_beta                 97.29(8)
_cell_angle_gamma                90
_cell_volume                     1903(3)
_cell_formula_units_Z            4
_cell_measurement_temperature    296(2)
_cell_measurement_reflns_used    2940
_cell_measurement_theta_min      2.77
_cell_measurement_theta_max      21.27

_exptl_crystal_description       block
_exptl_crystal_colour            colourless
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    ?
_exptl_crystal_density_diffrn    1.185
_exptl_crystal_F_000             728
_exptl_transmission_factor_min   ?
_exptl_transmission_factor_max   ?
_exptl_crystal_size_max          0.150
_exptl_crystal_size_mid          0.140
_exptl_crystal_size_min          0.130
_exptl_absorpt_coefficient_mu    0.079
_shelx_estimated_absorpt_T_min   0.988
_shelx_estimated_absorpt_T_max   0.990
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_correction_T_min  0.6800
_exptl_absorpt_correction_T_max  0.7457
_exptl_absorpt_process_details   SADABS
_exptl_absorpt_special_details   ?
_diffrn_ambient_temperature      296(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_source                   ?
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       'φ and ω scans'
_diffrn_detector_area_resol_mean ?
_diffrn_reflns_number            19789
_diffrn_reflns_av_unetI/netI     0.1095
_diffrn_reflns_av_R_equivalents  0.1026
_diffrn_reflns_limit_h_min       -11
_diffrn_reflns_limit_h_max       11
_diffrn_reflns_limit_k_min       -13
_diffrn_reflns_limit_k_max       7
_diffrn_reflns_limit_l_min       -28
_diffrn_reflns_limit_l_max       28
_diffrn_reflns_theta_min         2.762
_diffrn_reflns_theta_max         28.334
_diffrn_reflns_theta_full        25.242
_diffrn_measured_fraction_theta_max 0.989
_diffrn_measured_fraction_theta_full 0.999
_diffrn_reflns_Laue_measured_fraction_max 0.989
_diffrn_reflns_Laue_measured_fraction_full 0.999
_diffrn_reflns_point_group_measured_fraction_max 0.989
_diffrn_reflns_point_group_measured_fraction_full 0.999
_reflns_number_total             4698
_reflns_number_gt                1947
_reflns_threshold_expression     'I > 2σ(I)'
_reflns_Friedel_coverage         0.000
_reflns_Friedel_fraction_max     .
_reflns_Friedel_fraction_full    .

_reflns_special_details          
;
 Reflections were merged by SHELXL according to the crystal
 class for the calculation of statistics and refinement.
 
 _reflns_Friedel_fraction is defined as the number of unique
 Friedel pairs measured divided by the number that would be
 possible theoretically, ignoring centric projections and
 systematic absences.
;

_computing_data_collection       ?
_computing_cell_refinement       ?
_computing_data_reduction        ?
_computing_structure_solution    ?
_computing_structure_refinement  'SHELXL-2014/7 (Sheldrick, 2014)'
_computing_molecular_graphics    ?
_computing_publication_material  ?
_refine_special_details          ?
_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'w=1/[σ²(Fo²)+(0.1000P)²] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     ?
_atom_sites_solution_secondary   ?
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       .
_refine_ls_number_reflns         4698
_refine_ls_number_parameters     232
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.2019
_refine_ls_R_factor_gt           0.0768
_refine_ls_wR_factor_ref         0.2255
_refine_ls_wR_factor_gt          0.1784
_refine_ls_goodness_of_fit_ref   1.044
_refine_ls_restrained_S_all      1.044
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_site_symmetry_order
_atom_site_calc_flag
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
_atom_site_refinement_flags_occupancy
_atom_site_disorder_assembly
_atom_site_disorder_group
C1 C 1.0360(4) 0.8179(4) 0.72992(18) 0.0735(11) Uani 1 1 d . . . . .
H1A H 1.0496 0.7329 0.7126 0.110 Uiso 1 1 calc R U . . .
H1B H 0.9535 0.8152 0.7555 0.110 Uiso 1 1 calc R U . . .
H1C H 1.1295 0.8441 0.7552 0.110 Uiso 1 1 calc R U . . .
C2 C 0.9976(3) 0.9143(3) 0.67743(15) 0.0497(8) Uani 1 1 d . . . . .
C3 C 1.0913(4) 1.0208(3) 0.67145(18) 0.0595(10) Uani 1 1 d . . . . .
H3 H 1.1732 1.0378 0.7025 0.071 Uiso 1 1 calc R U . . .
C4 C 1.0653(4) 1.1013(3) 0.6208(2) 0.0642(10) Uani 1 1 d . . . . .
H4 H 1.1290 1.1732 0.6180 0.077 Uiso 1 1 calc R U . . .
C5 C 0.9463(4) 1.0782(3) 0.57330(17) 0.0606(9) Uani 1 1 d . . . . .
H5 H 0.9336 1.1326 0.5383 0.073 Uiso 1 1 calc R U . . .
C6 C 0.8454(3) 0.9749(3) 0.57720(15) 0.0484(8) Uani 1 1 d . . . . .
C7 C 0.8693(3) 0.8967(3) 0.63114(14) 0.0416(7) Uani 1 1 d . . . . .
C8 C 0.7163(4) 0.9506(4) 0.52506(15) 0.0696(10) Uani 1 1 d . . . . .
H8A H 0.7568 0.9107 0.4901 0.104 Uiso 1 1 calc R U . . .
H8B H 0.6681 1.0320 0.5120 0.104 Uiso 1 1 calc R U . . .
H8C H 0.6416 0.8935 0.5399 0.104 Uiso 1 1 calc R U . . .
C9 C 0.7860(4) 0.6788(3) 0.60196(16) 0.0549(9) Uani 1 1 d . . . . .
C10 C 0.6737(4) 0.5675(3) 0.59724(14) 0.0482(8) Uani 1 1 d . . . . .
C11 C 0.7384(5) 0.4430(3) 0.59775(16) 0.0661(10) Uani 1 1 d . . . . .
H11 H 0.8452 0.4344 0.6037 0.079 Uiso 1 1 calc R U . . .
C12 C 0.6496(6) 0.3335(3) 0.58969(18) 0.0773(12) Uani 1 1 d . . . . .
H12 H 0.6950 0.2512 0.5915 0.093 Uiso 1 1 calc R U . . .
C13 C 0.4926(6) 0.3462(4) 0.57884(17) 0.0790(13) Uani 1 1 d . . . . .
H13 H 0.4317 0.2717 0.5728 0.095 Uiso 1 1 calc R U . . .
C14 C 0.4226(4) 0.4678(3) 0.57661(15) 0.0646(10) Uani 1 1 d . . . . .
H14 H 0.3160 0.4749 0.5681 0.078 Uiso 1 1 calc R U . . .
C15 C 0.5137(4) 0.5791(3) 0.58726(14) 0.0500(8) Uani 1 1 d . . . . .
C16 C 0.2897(4) 0.7148(4) 0.57891(17) 0.0695(10) Uani 1 1 d . . . . .
H16A H 0.2482 0.6812 0.5384 0.104 Uiso 1 1 calc R U . . .
H16B H 0.2624 0.8052 0.5817 0.104 Uiso 1 1 calc R U . . .
H16C H 0.2484 0.6663 0.6113 0.104 Uiso 1 1 calc R U . . .
C17 C 0.6776(3) 0.7821(3) 0.68955(13) 0.0373(7) Uani 1 1 d . . . . .
C18 C 0.6017(3) 0.9040(3) 0.71290(14) 0.0415(7) Uani 1 1 d . . . . .
C19 C 0.4640(4) 0.8571(3) 0.74413(17) 0.0579(9) Uani 1 1 d . . . . .
H19A H 0.4126 0.9310 0.7596 0.087 Uiso 1 1 calc R U . . .
H19B H 0.4993 0.8001 0.7785 0.087 Uiso 1 1 calc R U . . .
H19C H 0.3937 0.8108 0.7139 0.087 Uiso 1 1 calc R U . . .
C20 C 0.7116(4) 0.9770(4) 0.76326(18) 0.0733(11) Uani 1 1 d . . . . .
H20A H 0.7938 1.0159 0.7440 0.110 Uiso 1 1 calc R U . . .
H20B H 0.7538 0.9165 0.7951 0.110 Uiso 1 1 calc R U . . .
H20C H 0.6557 1.0440 0.7820 0.110 Uiso 1 1 calc R U . . .
C21 C 0.5422(4) 0.9992(3) 0.65959(17) 0.0651(10) Uani 1 1 d . . . . .
H21A H 0.6280 1.0425 0.6447 0.098 Uiso 1 1 calc R U . . .
H21B H 0.4760 1.0629 0.6752 0.098 Uiso 1 1 calc R U . . .
H21C H 0.4856 0.9516 0.6256 0.098 Uiso 1 1 calc R U . . .
N1 N 0.7652(3) 0.7886(2) 0.63768(11) 0.0396(6) Uani 1 1 d . . . . .
O1 O 0.8957(3) 0.6746(2) 0.57282(15) 0.0946(10) Uani 1 1 d . . . . .
O2 O 0.4539(2) 0.7023(2) 0.58678(10) 0.0568(6) Uani 1 1 d . . . . .
O3 O 0.6648(2) 0.67762(19) 0.71439(9) 0.0507(6) Uani 1 1 d . . . . .


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes)
 are estimated using the full covariance matrix.  The cell esds are taken
 into account individually in the estimation of esds in distances, angles
 and torsion angles; correlations between esds in cell parameters are only
 used when they are defined by crystal symmetry.  An approximate (isotropic)
 treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
C1 C2 1.502(5) . ?
C1 H1A 0.9600 . ?
C1 H1B 0.9600 . ?
C1 H1C 0.9600 . ?
C2 C3 1.379(4) . ?
C2 C7 1.412(4) . ?
C3 C4 1.358(5) . ?
C3 H3 0.9300 . ?
C4 C5 1.380(5) . ?
C4 H4 0.9300 . ?
C5 C6 1.387(4) . ?
C5 H5 0.9300 . ?
C6 C7 1.400(4) . ?
C6 C8 1.505(5) . ?
C7 N1 1.451(4) . ?
C8 H8A 0.9600 . ?
C8 H8B 0.9600 . ?
C8 H8C 0.9600 . ?
C9 O1 1.210(4) . ?
C9 N1 1.385(4) . ?
C9 C10 1.500(4) . ?
C10 C15 1.394(5) . ?
C10 C11 1.395(4) . ?
C11 C12 1.362(5) . ?
C11 H11 0.9300 . ?
C12 C13 1.369(6) . ?
C12 H12 0.9300 . ?
C13 C14 1.385(5) . ?
C13 H13 0.9300 . ?
C14 C15 1.392(4) . ?
C14 H14 0.9300 . ?
C15 O2 1.365(4) . ?
C16 O2 1.430(4) . ?
C16 H16A 0.9600 . ?
C16 H16B 0.9600 . ?
C16 H16C 0.9600 . ?
C17 O3 1.206(3) . ?
C17 N1 1.429(4) . ?
C17 C18 1.528(4) . ?
C18 C19 1.527(4) . ?
C18 C21 1.541(4) . ?
C18 C20 1.544(4) . ?
C19 H19A 0.9600 . ?
C19 H19B 0.9600 . ?
C19 H19C 0.9600 . ?
C20 H20A 0.9600 . ?
C20 H20B 0.9600 . ?
C20 H20C 0.9600 . ?
C21 H21A 0.9600 . ?
C21 H21B 0.9600 . ?
C21 H21C 0.9600 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C2 C1 H1A 109.5 . . ?
C2 C1 H1B 109.5 . . ?
H1A C1 H1B 109.5 . . ?
C2 C1 H1C 109.5 . . ?
H1A C1 H1C 109.5 . . ?
H1B C1 H1C 109.5 . . ?
C3 C2 C7 117.7(3) . . ?
C3 C2 C1 120.7(3) . . ?
C7 C2 C1 121.6(3) . . ?
C4 C3 C2 120.8(3) . . ?
C4 C3 H3 119.6 . . ?
C2 C3 H3 119.6 . . ?
C3 C4 C5 121.3(3) . . ?
C3 C4 H4 119.4 . . ?
C5 C4 H4 119.4 . . ?
C4 C5 C6 120.8(3) . . ?
C4 C5 H5 119.6 . . ?
C6 C5 H5 119.6 . . ?
C5 C6 C7 117.2(3) . . ?
C5 C6 C8 120.3(3) . . ?
C7 C6 C8 122.5(3) . . ?
C6 C7 C2 121.9(3) . . ?
C6 C7 N1 119.1(3) . . ?
C2 C7 N1 118.8(3) . . ?
C6 C8 H8A 109.5 . . ?
C6 C8 H8B 109.5 . . ?
H8A C8 H8B 109.5 . . ?
C6 C8 H8C 109.5 . . ?
H8A C8 H8C 109.5 . . ?
H8B C8 H8C 109.5 . . ?
O1 C9 N1 118.8(3) . . ?
O1 C9 C10 119.6(3) . . ?
N1 C9 C10 121.6(3) . . ?
C15 C10 C11 118.6(3) . . ?
C15 C10 C9 125.6(3) . . ?
C11 C10 C9 115.6(3) . . ?
C12 C11 C10 121.8(4) . . ?
C12 C11 H11 119.1 . . ?
C10 C11 H11 119.1 . . ?
C11 C12 C13 119.1(4) . . ?
C11 C12 H12 120.4 . . ?
C13 C12 H12 120.4 . . ?
C12 C13 C14 121.4(4) . . ?
C12 C13 H13 119.3 . . ?
C14 C13 H13 119.3 . . ?
C13 C14 C15 119.3(4) . . ?
C13 C14 H14 120.4 . . ?
C15 C14 H14 120.4 . . ?
O2 C15 C14 123.0(3) . . ?
O2 C15 C10 117.1(3) . . ?
C14 C15 C10 119.8(3) . . ?
O2 C16 H16A 109.5 . . ?
O2 C16 H16B 109.5 . . ?
H16A C16 H16B 109.5 . . ?
O2 C16 H16C 109.5 . . ?
H16A C16 H16C 109.5 . . ?
H16B C16 H16C 109.5 . . ?
O3 C17 N1 118.3(2) . . ?
O3 C17 C18 120.8(3) . . ?
N1 C17 C18 121.0(2) . . ?
C19 C18 C17 106.6(2) . . ?
C19 C18 C21 108.2(3) . . ?
C17 C18 C21 113.2(3) . . ?
C19 C18 C20 107.6(3) . . ?
C17 C18 C20 111.5(3) . . ?
C21 C18 C20 109.5(3) . . ?
C18 C19 H19A 109.5 . . ?
C18 C19 H19B 109.5 . . ?
H19A C19 H19B 109.5 . . ?
C18 C19 H19C 109.5 . . ?
H19A C19 H19C 109.5 . . ?
H19B C19 H19C 109.5 . . ?
C18 C20 H20A 109.5 . . ?
C18 C20 H20B 109.5 . . ?
H20A C20 H20B 109.5 . . ?
C18 C20 H20C 109.5 . . ?
H20A C20 H20C 109.5 . . ?
H20B C20 H20C 109.5 . . ?
C18 C21 H21A 109.5 . . ?
C18 C21 H21B 109.5 . . ?
H21A C21 H21B 109.5 . . ?
C18 C21 H21C 109.5 . . ?
H21A C21 H21C 109.5 . . ?
H21B C21 H21C 109.5 . . ?
C9 N1 C17 120.8(2) . . ?
C9 N1 C7 116.0(2) . . ?
C17 N1 C7 121.0(2) . . ?
C15 O2 C16 117.5(3) . . ?

_refine_diff_density_max         0.815
_refine_diff_density_min         -0.239
_refine_diff_density_rms         0.053

