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Caption : figure s1: effect of glycyrrhizin on il-1β-induced pro-inflammatory mediators and ecm degradation-related genes in human oa chondrocytes. the mrna expression levels of inos, cox-2, il-6, tnf-α, mmp13, adamts5, collagen ii and aggrecan (a, b, c, d) were assayed by qrt-pcr. the values are mean ± sd. ##p < 0.01 compared with control group, **p< 0.01 compared with il-1β group, n=5.

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Caption : figure s2: effect of glycyrrhizin on il-1β-induced nf-κb and pi3k/akt signaling in human oa chondrocytes. the protein expressions of iκbα in cytoplasm and p65 in nuclear in chondrocytes treated as above were visualized by western blot (a), and quantified in (b). the protein expression levels of p-pi3k, pi3k, p-akt, akt were determined by western blot (c) and quantification analysis (d). the values are mean ± sd. ##p < 0.01 compared with control group, **p< 0.01 compared with il-1β group, n=5.