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Caption : supplementary figure1. (a) goods coverage index. (b) observed species index. (c) pd whole tree index. (d) simpson index. (e) ace index. (f) heat map of the differential kegg pathways. (g) correlation between sex hormones and scfas. data are expressed as medians with interquartile ranges. *p<0.05 versus the control group, #p<0.05, ###p<0.001 versus the letrozole group using lsd test. the r value between the butyrate level and lh/fsh ratio was -0.28 (p=0.023).

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Caption : supplementary figure2. (a) ovary weight of rats. (b) body weight gain at day 26. (c) trends of the body weight changes during the animal experiment. data are represented as mean ± sd. *p<0.05 versus the control group, #p<0.05, ###p<0.001 versus the letrozole group using lsd test.