# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2019

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_lborg1
_database_code_depnum_ccdc_archive 'CCDC 1883868'
loop_
_audit_author_name
_audit_author_address
'LEONI A. BARRIOS'
;UNIVERSITY OF BARCELONA
Spain
;
_audit_update_record             
;
2018-12-07 deposited with the CCDC.	2019-08-01 downloaded from the CCDC.
;
_audit_creation_date             2018-12-07
_audit_creation_method           
;
Olex2 1.2
(compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506)
;
_shelx_SHELXL_version_number     2018/3
_chemical_name_common            ?
_chemical_name_systematic        INDOLINE
_chemical_formula_moiety         'C18 H18 N2 O3'
_chemical_formula_sum            'C18 H18 N2 O3'
_chemical_formula_weight         310.34
_chemical_melting_point          ?
loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_H-M_alt        'P 1 21/n 1'
_space_group_name_Hall           '-P 2yn'
loop_
_space_group_symop_id
_space_group_symop_operation_xyz
1 'x, y, z'
2 '-x+1/2, y+1/2, -z+1/2'
3 '-x, -y, -z'
4 'x-1/2, -y-1/2, z-1/2'

_cell_length_a                   9.7644(15)
_cell_length_b                   12.097(2)
_cell_length_c                   13.137(2)
_cell_angle_alpha                90.00
_cell_angle_beta                 94.859(11)
_cell_angle_gamma                90.00
_cell_volume                     1546.1(5)
_cell_formula_units_Z            4
_cell_measurement_reflns_used    1270
_cell_measurement_temperature    100(2)
_cell_measurement_theta_max      21.58
_cell_measurement_theta_min      2.69
_exptl_absorpt_coefficient_mu    0.092
_exptl_absorpt_correction_T_max  0.7447
_exptl_absorpt_correction_T_min  0.5054
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   
'SADABS-2008/1 (Bruker,2008) was used for absorption correction. wR2(int) was 0.1637 before and 0.0749 after correction. The Ratio of minimum to maximum transmission is 0.6787. The λ/2 correction factor is 0.0015.'
_exptl_crystal_colour            'clear whiteish white'
_exptl_crystal_colour_lustre     clear
_exptl_crystal_colour_modifier   whiteish
_exptl_crystal_colour_primary    white
_exptl_crystal_density_diffrn    1.333
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    ?
_exptl_crystal_description       needle
_exptl_crystal_F_000             656
_exptl_crystal_size_max          0.117
_exptl_crystal_size_mid          0.085
_exptl_crystal_size_min          0.017
_exptl_special_details           
;
 ? 
;
_diffrn_reflns_av_R_equivalents  0.0758
_diffrn_reflns_av_unetI/netI     0.0760
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_k_max       12
_diffrn_reflns_limit_k_min       -11
_diffrn_reflns_limit_l_max       13
_diffrn_reflns_limit_l_min       -13
_diffrn_reflns_number            6728
_diffrn_reflns_theta_full        25.027
_diffrn_reflns_theta_max         25.027
_diffrn_reflns_theta_min         1.761
_diffrn_ambient_temperature      100.0
_diffrn_detector_area_resol_mean ?
_diffrn_measured_fraction_theta_full 0.995
_diffrn_measured_fraction_theta_max 0.995
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       'φ and ω scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_source                   'fine-focus sealed tube'
_diffrn_standards_number         0
_reflns_number_gt                1420
_reflns_number_total             1886
_reflns_threshold_expression     >2sigma(I)
_computing_cell_refinement       'SAINT v8.34A (Bruker, 2013)'
_computing_data_collection       ?
_computing_data_reduction        'SAINT v8.34A (Bruker, 2013)'
_computing_molecular_graphics    'Olex2 (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 (Dolomanov et al., 2009)'
_computing_structure_refinement  'XL (Sheldrick, 2008)'
_computing_structure_solution    'XS (Sheldrick, 2008)'
_refine_diff_density_max         0.396
_refine_diff_density_min         -0.458
_refine_diff_density_rms         0.143
_refine_ls_extinction_coef       ?
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.109
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     221
_refine_ls_number_reflns         1886
_refine_ls_number_restraints     233
_refine_ls_R_factor_all          0.0873
_refine_ls_R_factor_gt           0.0617
_refine_ls_restrained_S_all      1.042
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.1110P)²+0.0290P] where P=(Fo²+2Fc²)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1688
_refine_ls_wR_factor_ref         0.1920
_refine_special_details          
;
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;
_olex2_refinement_description    
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H) groups, All C(H,H) groups
 At 1.5 times of:
  All C(H,H,H) groups
2. Rigid bond restraints
 All non-hydrogen atoms
 with sigma for 1-2 distances of 0.01 and sigma for 1-3 distances of 0.01
3. Uiso/Uaniso restraints and constraints
All non-hydrogen atoms have similar U: within 1.7A with sigma of 0.04 and sigma
for terminal atoms of 0.08
Uanis(N1) \\sim Ueq: with sigma of 0.1 and sigma for terminal atoms of 0.2
4. Others
 Sof(O1A)=1-FVAR(1)
 Sof(O1)=FVAR(1)
5.a Secondary CH2 refined with riding coordinates:
 C8(H8a,H8b)
5.b Aromatic/amide H refined with riding coordinates:
 C4(H4), C5(H5), C6(H6), C12(H12), C13(H13), C14(H14), C15(H15)
5.c Idealised Me refined as rotating group:
 C16(H16a,H16b,H16c), C17(H17a,H17b,H17c), C19(H19a,H19b,H19c)
;
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_calc_flag
_atom_site_disorder_assembly
_atom_site_disorder_group
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
C2 C 0.1203(3) 0.2907(3) 0.8481(3) 0.0203(9) Uani 1 d . . . U
C3 C 0.1368(3) 0.3914(3) 0.8974(3) 0.0192(9) Uani 1 d . . . U
C4 C 0.1709(3) 0.3971(3) 1.0017(3) 0.0215(9) Uani 1 d . . . U
H4 H 0.1763 0.4662 1.0362 0.026 Uiso 1 calc . . R .
C5 C 0.1972(4) 0.2987(3) 1.0547(3) 0.0244(10) Uani 1 d . . . U
H5 H 0.2221 0.3011 1.1261 0.029 Uiso 1 calc . . R .
C6 C 0.1876(4) 0.1971(3) 1.0053(3) 0.0247(10) Uani 1 d . . . U
H6 H 0.2070 0.1305 1.0421 0.030 Uiso 1 calc . . R .
C7 C 0.1497(4) 0.1946(3) 0.9024(3) 0.0235(9) Uani 1 d . . . U
C8 C 0.0707(4) 0.3072(3) 0.7378(3) 0.0245(10) Uani 1 d . . . U
H8A H -0.0025 0.2536 0.7159 0.029 Uiso 1 calc . . R .
H8B H 0.1470 0.2994 0.6933 0.029 Uiso 1 calc . . R .
C9 C 0.0148(4) 0.4261(3) 0.7352(3) 0.0213(9) Uani 1 d . . . U
C10 C 0.1118(4) 0.5886(3) 0.8389(3) 0.0217(9) Uani 1 d . . . U
C11 C 0.2188(4) 0.6313(3) 0.9177(3) 0.0220(9) Uani 1 d . . . U
C12 C 0.1878(4) 0.7200(3) 0.9788(3) 0.0245(10) Uani 1 d . . . U
H12 H 0.0979 0.7505 0.9742 0.029 Uiso 1 calc . . R .
C13 C 0.2911(4) 0.7633(3) 1.0468(3) 0.0269(10) Uani 1 d . . . U
H13 H 0.2724 0.8228 1.0908 0.032 Uiso 1 calc . . R .
C14 C 0.4211(4) 0.7184(3) 1.0493(3) 0.0279(10) Uani 1 d . . . U
H14 H 0.4942 0.7471 1.0939 0.033 Uiso 1 calc . . R .
C15 C 0.4426(4) 0.6305(3) 0.9852(3) 0.0271(10) Uani 1 d . . . U
H15 H 0.5324 0.5998 0.9874 0.033 Uiso 1 calc . . R .
C16 C 0.0342(4) 0.4810(3) 0.6339(2) 0.0276(10) Uani 1 d . . . U
H16A H -0.0149 0.5518 0.6299 0.041 Uiso 1 calc . . GR .
H16B H -0.0024 0.4329 0.5780 0.041 Uiso 1 calc . . GR .
H16C H 0.1323 0.4939 0.6281 0.041 Uiso 1 calc . . GR .
C17 C -0.1374(4) 0.4269(3) 0.7576(3) 0.0263(10) Uani 1 d . . . U
H17A H -0.1476 0.3885 0.8222 0.039 Uiso 1 calc . . GR .
H17B H -0.1924 0.3893 0.7021 0.039 Uiso 1 calc . . GR .
H17C H -0.1689 0.5035 0.7626 0.039 Uiso 1 calc . . GR .
C18 C 0.0248(4) 0.0361(3) 0.8388(3) 0.0362(11) Uani 1 d . . . U
C19 C 0.0379(4) -0.0672(3) 0.7793(3) 0.0334(11) Uani 1 d A . . U
H19A H 0.0766 -0.0499 0.7147 0.050 Uiso 1 calc . . GR .
H19B H -0.0529 -0.1009 0.7652 0.050 Uiso 1 calc . . GR .
H19C H 0.0988 -0.1188 0.8188 0.050 Uiso 1 calc . . GR .
N1 N 0.0984(3) 0.4769(2) 0.8253(2) 0.0202(8) Uani 1 d . . . U
N2 N 0.3450(3) 0.5860(2) 0.9203(2) 0.0247(8) Uani 1 d . . . U
O1 O -0.0730(19) 0.060(2) 0.887(3) 0.051(4) Uani 0.59(10) d A 1 . U
O2 O 0.1451(2) 0.0926(2) 0.84990(18) 0.0268(7) Uani 1 d A . . U
O3 O 0.0430(2) 0.6552(2) 0.78524(18) 0.0272(7) Uani 1 d . . . U
O1A O -0.080(2) 0.089(4) 0.844(7) 0.064(12) Uani 0.41(10) d A 2 . U

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
C2 0.0105(19) 0.028(2) 0.0224(19) 0.0002(17) -0.0004(16) -0.0024(17)
C3 0.0099(19) 0.022(2) 0.0255(19) 0.0017(17) 0.0003(16) -0.0024(17)
C4 0.015(2) 0.021(2) 0.028(2) -0.0034(18) 0.0006(17) 0.0005(17)
C5 0.014(2) 0.033(3) 0.025(2) -0.0016(18) 0.0001(17) -0.0017(18)
C6 0.018(2) 0.024(2) 0.031(2) 0.0053(18) -0.0016(18) 0.0018(18)
C7 0.017(2) 0.019(2) 0.034(2) -0.0028(18) 0.0008(17) -0.0006(17)
C8 0.021(2) 0.026(2) 0.026(2) -0.0017(17) 0.0005(17) -0.0001(17)
C9 0.022(2) 0.020(2) 0.0217(19) -0.0039(16) -0.0026(16) 0.0000(17)
C10 0.017(2) 0.022(2) 0.026(2) -0.0021(18) 0.0035(17) -0.0024(18)
C11 0.018(2) 0.020(2) 0.028(2) 0.0012(17) 0.0027(16) 0.0002(17)
C12 0.020(2) 0.023(2) 0.031(2) 0.0021(18) 0.0043(17) -0.0024(18)
C13 0.026(2) 0.025(2) 0.029(2) -0.0044(19) 0.0029(18) -0.0073(19)
C14 0.025(2) 0.027(2) 0.031(2) 0.0016(18) -0.0029(18) -0.0048(19)
C15 0.021(2) 0.024(2) 0.036(2) 0.0053(19) -0.0026(18) -0.0019(18)
C16 0.032(2) 0.025(2) 0.025(2) -0.0012(18) 0.0015(18) -0.0005(19)
C17 0.021(2) 0.028(2) 0.029(2) 0.0018(18) -0.0037(17) 0.0003(17)
C18 0.027(3) 0.031(3) 0.049(3) -0.005(2) 0.001(2) -0.002(2)
C19 0.033(3) 0.022(2) 0.045(2) -0.0031(19) 0.005(2) -0.0063(19)
N1 0.0174(18) 0.0193(18) 0.0233(16) 0.0001(14) -0.0025(13) -0.0021(14)
N2 0.0194(19) 0.0223(19) 0.0322(18) 0.0020(15) 0.0012(15) -0.0022(15)
O1 0.037(5) 0.036(8) 0.084(10) -0.020(7) 0.031(5) -0.009(5)
O2 0.0203(15) 0.0209(16) 0.0394(15) -0.0038(12) 0.0039(12) -0.0010(12)
O3 0.0247(16) 0.0212(16) 0.0345(15) -0.0010(13) -0.0040(12) 0.0058(12)
O1A 0.017(5) 0.042(12) 0.13(3) -0.040(16) 0.019(11) -0.016(6)

_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;
loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
C2 C3 1.383(5) . ?
C2 C7 1.381(5) . ?
C2 C8 1.501(5) . ?
C3 C4 1.384(5) . ?
C3 N1 1.431(4) . ?
C4 C5 1.391(5) . ?
C5 C6 1.390(5) . ?
C6 C7 1.371(5) . ?
C7 O2 1.413(4) . ?
C8 C9 1.538(5) . ?
C9 C16 1.514(5) . ?
C9 C17 1.539(5) . ?
C9 N1 1.510(5) . ?
C10 C11 1.500(5) . ?
C10 N1 1.367(5) . ?
C10 O3 1.231(4) . ?
C11 C12 1.388(5) . ?
C11 N2 1.346(4) . ?
C12 C13 1.393(5) . ?
C13 C14 1.378(5) . ?
C14 C15 1.384(5) . ?
C15 N2 1.337(5) . ?
C18 C19 1.485(5) . ?
C18 O1 1.229(16) . ?
C18 O2 1.356(5) . ?
C18 O1A 1.21(3) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C3 C2 C8 110.5(3) . . ?
C7 C2 C3 119.2(3) . . ?
C7 C2 C8 130.3(3) . . ?
C2 C3 C4 121.1(3) . . ?
C2 C3 N1 108.2(3) . . ?
C4 C3 N1 130.3(3) . . ?
C3 C4 C5 118.1(3) . . ?
C6 C5 C4 121.4(3) . . ?
C7 C6 C5 118.8(3) . . ?
C2 C7 O2 119.1(3) . . ?
C6 C7 C2 121.2(3) . . ?
C6 C7 O2 119.7(3) . . ?
C2 C8 C9 103.3(3) . . ?
C8 C9 C17 110.4(3) . . ?
C16 C9 C8 111.1(3) . . ?
C16 C9 C17 111.0(3) . . ?
N1 C9 C8 101.3(3) . . ?
N1 C9 C16 114.3(3) . . ?
N1 C9 C17 108.3(3) . . ?
N1 C10 C11 118.9(3) . . ?
O3 C10 C11 119.0(3) . . ?
O3 C10 N1 122.0(3) . . ?
C12 C11 C10 119.5(3) . . ?
N2 C11 C10 117.4(3) . . ?
N2 C11 C12 122.9(3) . . ?
C11 C12 C13 118.7(3) . . ?
C14 C13 C12 118.8(4) . . ?
C13 C14 C15 118.4(4) . . ?
N2 C15 C14 124.1(4) . . ?
O1 C18 C19 125.3(10) . . ?
O1 C18 O2 122.0(8) . . ?
O2 C18 C19 111.6(3) . . ?
O1A C18 C19 125.9(15) . . ?
O1A C18 O1 32(3) . . ?
O1A C18 O2 117.0(16) . . ?
C3 N1 C9 108.5(3) . . ?
C10 N1 C3 127.7(3) . . ?
C10 N1 C9 122.9(3) . . ?
C15 N2 C11 117.0(3) . . ?
C18 O2 C7 119.0(3) . . ?

_olex2_submission_special_instructions 'No special instructions were received'
