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Caption : figure s1. the uv-vis absorption spectrum for icg (a), sorafenib(b) with different concentration.

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Caption : figure s2. the drug loading efficiency of icg and sorafenib in (icg+s)@msio2 nanoparticles.

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Caption : figure s3. the photothermal performance of the msio2 nanoparticles.

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Caption : figure s4. hematoxylin and eosinsurvival stained for the major organs of mice after treating with different samples 15 days. (*) p < 0.05, (***) p < 0.001. the scale bars were 50 μm.

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Caption : figure s5. immune-enhanced function of (icg+s)@msio2 (a) representative images and statistical analysis of ifn-g cd8+ t cells, nk, tem and tcm cells in tumor analyzed with flow cytometry; (b) representative images and statistical analysis of ifn-g cd8+ t cells, nk, tem andtcm cells in spleen analyzed with flow cytometry.