# Electronic Supplementary Material (ESI) for Chemical Communications
# This journal is © The Royal Society of Chemistry 2012


data_global
_journal_name_full               Chem.Commun.
_journal_coden_cambridge         0182
_journal_year                    ?
_journal_volume                  ?
_journal_page_first              ?
loop_
_publ_author_name
'Zhiyuan Chen'
'Liang Gao'
'Shengqing Ye'
'Qiuping Ding'
'Jie Wu'
_publ_contact_author_email       jie_wu@fudan.edu.cn
_publ_contact_author_name        'Jie Wu'

data_a11201b
_database_code_depnum_ccdc_archive 'CCDC 868983'
#TrackingRef '- a11201b.cif'

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
;
?
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C23 H20 N2 O3'
_chemical_formula_weight         372.41

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Triclinic
_symmetry_space_group_name_H-M   P-1

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, -y, -z'

_cell_length_a                   7.609(3)
_cell_length_b                   9.954(4)
_cell_length_c                   13.193(5)
_cell_angle_alpha                96.213(5)
_cell_angle_beta                 97.796(5)
_cell_angle_gamma                106.563(6)
_cell_volume                     937.5(7)
_cell_formula_units_Z            2
_cell_measurement_temperature    293(2)
_cell_measurement_reflns_used    796
_cell_measurement_theta_min      2.470
_cell_measurement_theta_max      24.812

_exptl_crystal_description       block
_exptl_crystal_colour            colorless
_exptl_crystal_size_max          0.25
_exptl_crystal_size_mid          0.10
_exptl_crystal_size_min          0.08
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.319
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             392
_exptl_absorpt_coefficient_mu    0.088
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_correction_T_min  0.9783
_exptl_absorpt_correction_T_max  0.9930
_exptl_absorpt_process_details   ?

_exptl_special_details           
;
?
;

_diffrn_ambient_temperature      293(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  'CCD area detector'
_diffrn_measurement_method       'phi and omega scans'
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            3876
_diffrn_reflns_av_R_equivalents  0.0287
_diffrn_reflns_av_sigmaI/netI    0.0425
_diffrn_reflns_limit_h_min       -8
_diffrn_reflns_limit_h_max       8
_diffrn_reflns_limit_k_min       -11
_diffrn_reflns_limit_k_max       11
_diffrn_reflns_limit_l_min       -15
_diffrn_reflns_limit_l_max       15
_diffrn_reflns_theta_min         1.58
_diffrn_reflns_theta_max         25.01
_reflns_number_total             3215
_reflns_number_gt                2120
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'Bruker SMART'
_computing_cell_refinement       'Bruker SMART'
_computing_data_reduction        'Bruker SHELXTL'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'

_refine_special_details          
;
Refinement of F^2^ against ALL reflections. The weighted R-factor wR and
goodness of fit S are based on F^2^, conventional R-factors R are based
on F, with F set to zero for negative F^2^. The threshold expression of
F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is
not relevant to the choice of reflections for refinement. R-factors based
on F^2^ are statistically about twice as large as those based on F, and R-
factors based on ALL data will be even larger.
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[\s^2^(Fo^2^)+(0.1013P)^2^+0.0000P] where P=(Fo^2^+2Fc^2^)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    mixed
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_number_reflns         3215
_refine_ls_number_parameters     264
_refine_ls_number_restraints     2
_refine_ls_R_factor_all          0.0794
_refine_ls_R_factor_gt           0.0564
_refine_ls_wR_factor_ref         0.1574
_refine_ls_wR_factor_gt          0.1430
_refine_ls_goodness_of_fit_ref   0.929
_refine_ls_restrained_S_all      0.930
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
N1 N 0.3955(3) 0.47223(18) 0.17614(13) 0.0462(5) Uani 1 1 d . . .
N2 N 0.4928(3) 0.4892(2) 0.27294(14) 0.0524(5) Uani 1 1 d . A .
O1 O 0.6634(3) 0.91604(18) 0.14645(13) 0.0756(6) Uani 1 1 d . A .
O2 O 0.6109(2) 0.92491(15) 0.30885(12) 0.0582(5) Uani 1 1 d . A .
O3 O 0.8301(4) 0.7834(3) 0.4200(2) 0.0810(12) Uani 0.695(6) 1 d PD A 1
C18 C 0.7058(4) 0.6779(3) 0.3961(2) 0.0693(8) Uani 0.695(6) 1 d PD A 1
H18A H 0.6845 0.6194 0.4463 0.083 Uiso 0.695(6) 1 calc PR A 1
O3' O 0.6986(14) 0.6244(8) 0.4686(6) 0.117(4) Uani 0.305(6) 1 d PD A 2
C18' C 0.7058(4) 0.6779(3) 0.3961(2) 0.0693(8) Uani 0.305(6) 1 d P A 2
H18B H 0.8016 0.7621 0.4012 0.083 Uiso 0.305(6) 1 calc PR A 2
C1 C 0.2831(3) 0.3395(2) 0.12314(17) 0.0476(6) Uani 1 1 d . . .
C2 C 0.2525(3) 0.2134(2) 0.17659(17) 0.0486(6) Uani 1 1 d . . .
C3 C 0.2405(3) 0.0834(2) 0.12081(19) 0.0546(6) Uani 1 1 d . . .
H3 H 0.2615 0.0784 0.0529 0.066 Uiso 1 1 calc R . .
C4 C 0.1977(4) -0.0375(3) 0.1654(2) 0.0631(7) Uani 1 1 d . . .
H4 H 0.1911 -0.1237 0.1275 0.076 Uiso 1 1 calc R . .
C5 C 0.1648(4) -0.0327(3) 0.2652(2) 0.0680(7) Uani 1 1 d . . .
H5 H 0.1347 -0.1154 0.2946 0.082 Uiso 1 1 calc R . .
C6 C 0.1764(4) 0.0955(3) 0.3216(2) 0.0661(7) Uani 1 1 d . . .
H6 H 0.1549 0.0993 0.3894 0.079 Uiso 1 1 calc R . .
C7 C 0.2197(4) 0.2175(3) 0.27804(18) 0.0571(6) Uani 1 1 d . . .
H7 H 0.2271 0.3035 0.3166 0.068 Uiso 1 1 calc R . .
C8 C 0.2011(3) 0.3361(2) 0.02528(17) 0.0510(6) Uani 1 1 d . . .
H8 H 0.1299 0.2488 -0.0129 0.061 Uiso 1 1 calc R . .
C9 C 0.2183(3) 0.4599(2) -0.02245(16) 0.0492(6) Uani 1 1 d . . .
C10 C 0.1232(4) 0.4529(3) -0.12295(18) 0.0589(7) Uani 1 1 d . . .
H10 H 0.0526 0.3652 -0.1607 0.071 Uiso 1 1 calc R . .
C11 C 0.1334(4) 0.5725(3) -0.16548(19) 0.0653(7) Uani 1 1 d . . .
H11 H 0.0694 0.5661 -0.2320 0.078 Uiso 1 1 calc R . .
C12 C 0.2382(4) 0.7040(3) -0.11073(19) 0.0643(7) Uani 1 1 d . . .
H12 H 0.2419 0.7855 -0.1399 0.077 Uiso 1 1 calc R . .
C13 C 0.3363(4) 0.7145(3) -0.01392(18) 0.0567(6) Uani 1 1 d . . .
H13 H 0.4099 0.8031 0.0213 0.068 Uiso 1 1 calc R . .
C14 C 0.3273(3) 0.5934(2) 0.03285(16) 0.0465(5) Uani 1 1 d . . .
C15 C 0.4222(3) 0.5978(2) 0.13600(16) 0.0448(5) Uani 1 1 d . . .
C16 C 0.5423(3) 0.7020(2) 0.21443(17) 0.0485(6) Uani 1 1 d . A .
C17 C 0.5794(3) 0.6278(2) 0.29537(17) 0.0513(6) Uani 1 1 d . . .
C19 C 0.6122(3) 0.8561(2) 0.21645(18) 0.0513(6) Uani 1 1 d . . .
C20 C 0.6799(4) 1.0781(2) 0.32263(18) 0.0561(6) Uani 1 1 d . . .
H20A H 0.5927 1.1147 0.2822 0.067 Uiso 1 1 calc R A .
H20B H 0.7984 1.1079 0.2991 0.067 Uiso 1 1 calc R . .
C21 C 0.7035(4) 1.1350(2) 0.43514(19) 0.0615(7) Uani 1 1 d . A .
H21A H 0.7936 1.1002 0.4747 0.074 Uiso 1 1 calc R . .
H21B H 0.5858 1.1008 0.4588 0.074 Uiso 1 1 calc R . .
C22 C 0.7677(5) 1.2941(3) 0.4544(2) 0.0750(8) Uani 1 1 d . . .
H22A H 0.8842 1.3274 0.4293 0.090 Uiso 1 1 calc R A .
H22B H 0.6768 1.3280 0.4147 0.090 Uiso 1 1 calc R . .
C23 C 0.7957(5) 1.3576(3) 0.5659(2) 0.0879(10) Uani 1 1 d . A .
H23A H 0.6847 1.3188 0.5933 0.132 Uiso 1 1 calc R . .
H23B H 0.8223 1.4587 0.5713 0.132 Uiso 1 1 calc R . .
H23C H 0.8980 1.3361 0.6044 0.132 Uiso 1 1 calc R . .

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
N1 0.0487(12) 0.0461(10) 0.0405(10) -0.0001(8) 0.0039(8) 0.0134(9)
N2 0.0557(12) 0.0538(12) 0.0425(10) 0.0005(9) -0.0032(9) 0.0163(10)
O1 0.0942(15) 0.0638(11) 0.0541(11) 0.0044(9) 0.0213(10) -0.0010(10)
O2 0.0756(12) 0.0429(9) 0.0497(9) 0.0010(7) 0.0128(8) 0.0095(8)
O3 0.072(2) 0.069(2) 0.078(2) -0.0122(15) -0.0229(15) 0.0091(17)
C18 0.077(2) 0.0656(18) 0.0565(17) 0.0008(15) -0.0091(15) 0.0207(17)
O3' 0.164(9) 0.100(6) 0.074(5) 0.016(4) -0.027(5) 0.042(6)
C18' 0.077(2) 0.0656(18) 0.0565(17) 0.0008(15) -0.0091(15) 0.0207(17)
C1 0.0473(14) 0.0476(13) 0.0456(12) -0.0009(10) 0.0080(10) 0.0137(11)
C2 0.0437(13) 0.0526(13) 0.0455(12) 0.0006(10) 0.0053(10) 0.0121(10)
C3 0.0530(15) 0.0502(14) 0.0540(14) -0.0007(11) 0.0091(11) 0.0088(11)
C4 0.0588(16) 0.0493(14) 0.0726(18) -0.0012(12) 0.0065(13) 0.0093(12)
C5 0.0663(18) 0.0579(16) 0.0736(18) 0.0153(14) 0.0086(14) 0.0086(13)
C6 0.0696(18) 0.0710(18) 0.0534(15) 0.0135(13) 0.0122(13) 0.0127(14)
C7 0.0606(16) 0.0562(14) 0.0523(14) 0.0022(11) 0.0106(12) 0.0162(12)
C8 0.0530(14) 0.0494(13) 0.0440(13) -0.0025(10) 0.0047(11) 0.0104(11)
C9 0.0486(14) 0.0566(14) 0.0409(12) 0.0023(10) 0.0088(10) 0.0151(11)
C10 0.0553(16) 0.0702(16) 0.0446(13) 0.0004(12) 0.0048(11) 0.0135(13)
C11 0.0682(18) 0.0848(19) 0.0412(13) 0.0104(13) 0.0052(12) 0.0222(15)
C12 0.0719(18) 0.0723(17) 0.0519(14) 0.0212(13) 0.0143(13) 0.0209(14)
C13 0.0598(16) 0.0580(14) 0.0499(14) 0.0090(11) 0.0122(12) 0.0125(12)
C14 0.0440(13) 0.0552(13) 0.0408(12) 0.0048(10) 0.0115(10) 0.0151(11)
C15 0.0432(13) 0.0475(12) 0.0431(12) 0.0026(10) 0.0107(10) 0.0129(10)
C16 0.0488(14) 0.0487(13) 0.0456(12) 0.0013(10) 0.0096(10) 0.0124(11)
C17 0.0509(15) 0.0532(14) 0.0446(12) -0.0040(10) 0.0025(11) 0.0149(11)
C19 0.0463(14) 0.0547(14) 0.0466(13) 0.0007(11) 0.0064(10) 0.0092(11)
C20 0.0618(16) 0.0428(13) 0.0561(14) 0.0047(11) 0.0075(12) 0.0063(11)
C21 0.0746(19) 0.0477(14) 0.0564(15) 0.0051(11) 0.0136(13) 0.0097(13)
C22 0.093(2) 0.0494(15) 0.0702(18) 0.0039(13) 0.0034(16) 0.0097(14)
C23 0.105(3) 0.0641(18) 0.084(2) -0.0164(15) 0.0168(19) 0.0207(17)

_geom_special_details            
;
All esds (except the esd in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell esds are taken
into account individually in the estimation of esds in distances, angles
and torsion angles; correlations between esds in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
N1 N2 1.354(2) . ?
N1 C15 1.383(3) . ?
N1 C1 1.400(3) . ?
N2 C17 1.328(3) . ?
O1 C19 1.202(3) . ?
O2 C19 1.335(3) . ?
O2 C20 1.447(3) . ?
O3 C18 1.174(3) . ?
C18 C17 1.474(3) . ?
C18 H18A 0.9300 . ?
C1 C8 1.348(3) . ?
C1 C2 1.482(3) . ?
C2 C3 1.390(3) . ?
C2 C7 1.393(3) . ?
C3 C4 1.372(3) . ?
C3 H3 0.9300 . ?
C4 C5 1.372(4) . ?
C4 H4 0.9300 . ?
C5 C6 1.379(4) . ?
C5 H5 0.9300 . ?
C6 C7 1.375(3) . ?
C6 H6 0.9300 . ?
C7 H7 0.9300 . ?
C8 C9 1.425(3) . ?
C8 H8 0.9300 . ?
C9 C10 1.406(3) . ?
C9 C14 1.408(3) . ?
C10 C11 1.358(3) . ?
C10 H10 0.9300 . ?
C11 C12 1.383(4) . ?
C11 H11 0.9300 . ?
C12 C13 1.366(3) . ?
C12 H12 0.9300 . ?
C13 C14 1.402(3) . ?
C13 H13 0.9300 . ?
C14 C15 1.442(3) . ?
C15 C16 1.397(3) . ?
C16 C17 1.405(3) . ?
C16 C19 1.470(3) . ?
C20 C21 1.498(3) . ?
C20 H20A 0.9700 . ?
C20 H20B 0.9700 . ?
C21 C22 1.499(3) . ?
C21 H21A 0.9700 . ?
C21 H21B 0.9700 . ?
C22 C23 1.498(4) . ?
C22 H22A 0.9700 . ?
C22 H22B 0.9700 . ?
C23 H23A 0.9600 . ?
C23 H23B 0.9600 . ?
C23 H23C 0.9600 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
N2 N1 C15 113.05(17) . . ?
N2 N1 C1 122.41(17) . . ?
C15 N1 C1 124.53(18) . . ?
C17 N2 N1 104.05(17) . . ?
C19 O2 C20 116.48(18) . . ?
O3 C18 C17 127.4(3) . . ?
O3 C18 H18A 116.3 . . ?
C17 C18 H18A 116.3 . . ?
C8 C1 N1 116.5(2) . . ?
C8 C1 C2 123.5(2) . . ?
N1 C1 C2 119.96(19) . . ?
C3 C2 C7 118.5(2) . . ?
C3 C2 C1 118.8(2) . . ?
C7 C2 C1 122.5(2) . . ?
C4 C3 C2 120.4(2) . . ?
C4 C3 H3 119.8 . . ?
C2 C3 H3 119.8 . . ?
C5 C4 C3 120.8(2) . . ?
C5 C4 H4 119.6 . . ?
C3 C4 H4 119.6 . . ?
C4 C5 C6 119.5(2) . . ?
C4 C5 H5 120.2 . . ?
C6 C5 H5 120.2 . . ?
C7 C6 C5 120.3(2) . . ?
C7 C6 H6 119.8 . . ?
C5 C6 H6 119.8 . . ?
C6 C7 C2 120.5(2) . . ?
C6 C7 H7 119.8 . . ?
C2 C7 H7 119.8 . . ?
C1 C8 C9 123.1(2) . . ?
C1 C8 H8 118.4 . . ?
C9 C8 H8 118.4 . . ?
C10 C9 C14 118.8(2) . . ?
C10 C9 C8 121.4(2) . . ?
C14 C9 C8 119.8(2) . . ?
C11 C10 C9 120.8(2) . . ?
C11 C10 H10 119.6 . . ?
C9 C10 H10 119.6 . . ?
C10 C11 C12 120.5(2) . . ?
C10 C11 H11 119.7 . . ?
C12 C11 H11 119.7 . . ?
C13 C12 C11 120.3(2) . . ?
C13 C12 H12 119.9 . . ?
C11 C12 H12 119.9 . . ?
C12 C13 C14 120.7(2) . . ?
C12 C13 H13 119.7 . . ?
C14 C13 H13 119.7 . . ?
C13 C14 C9 118.9(2) . . ?
C13 C14 C15 123.4(2) . . ?
C9 C14 C15 117.66(19) . . ?
N1 C15 C16 105.14(19) . . ?
N1 C15 C14 118.34(19) . . ?
C16 C15 C14 136.5(2) . . ?
C15 C16 C17 104.69(19) . . ?
C15 C16 C19 129.1(2) . . ?
C17 C16 C19 126.2(2) . . ?
N2 C17 C16 113.1(2) . . ?
N2 C17 C18 116.4(2) . . ?
C16 C17 C18 130.4(2) . . ?
O1 C19 O2 122.9(2) . . ?
O1 C19 C16 126.6(2) . . ?
O2 C19 C16 110.5(2) . . ?
O2 C20 C21 108.82(18) . . ?
O2 C20 H20A 109.9 . . ?
C21 C20 H20A 109.9 . . ?
O2 C20 H20B 109.9 . . ?
C21 C20 H20B 109.9 . . ?
H20A C20 H20B 108.3 . . ?
C20 C21 C22 111.6(2) . . ?
C20 C21 H21A 109.3 . . ?
C22 C21 H21A 109.3 . . ?
C20 C21 H21B 109.3 . . ?
C22 C21 H21B 109.3 . . ?
H21A C21 H21B 108.0 . . ?
C23 C22 C21 114.2(2) . . ?
C23 C22 H22A 108.7 . . ?
C21 C22 H22A 108.7 . . ?
C23 C22 H22B 108.7 . . ?
C21 C22 H22B 108.7 . . ?
H22A C22 H22B 107.6 . . ?
C22 C23 H23A 109.5 . . ?
C22 C23 H23B 109.5 . . ?
H23A C23 H23B 109.5 . . ?
C22 C23 H23C 109.5 . . ?
H23A C23 H23C 109.5 . . ?
H23B C23 H23C 109.5 . . ?

_diffrn_measured_fraction_theta_max 0.976
_diffrn_reflns_theta_full        25.01
_diffrn_measured_fraction_theta_full 0.976
_refine_diff_density_max         0.223
_refine_diff_density_min         -0.239
_refine_diff_density_rms         0.051