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["Gene","PM11_count","PM21_count","PM32_count","baseMean","CN11_count","CN12_count","CN13_count","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSG00000130487",32,22,27,14.5110671911276,0,0,0,172.009544837664,7.42634481230617,4.02505647824812e-09,2.4552589928036e-08,"up","yes","KLHDC7B","protein_coding","chr22:50545891-50551023:+","gi|206597556|ref|NP_612442.2|",2291,0,"kelch domain-containing protein 7B [Homo sapiens]","gi|6862558|gb|U62317.2|HUB384D8",5133,0,"Homo sapiens chromosome 22q13 BAC clone CIT987SK-384D8 complete sequence","Q96G42",887,0,"Kelch domain-containing protein 7B",".",".",".",".","pfam01344","Kelch_1","Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that the Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.","GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;",".",".","."]
["ENSG00000267056",38,43,39,21.7305779399795,0,0,1,131.351264289662,7.03728627662349,1.17357168328563e-08,6.90117397171134e-08,"up","yes","AC005336.1","processed_pseudogene","chr19:15910582-15911824:-","gi|297686897|ref|XP_002820968.1|",1795,0,"PREDICTED: inositol polyphosphate multikinase isoform X2 [Pongo abelii]","gi|586798757|ref|NG_021743.3|",1243,0,"Homo sapiens inositol polyphosphate multikinase pseudogene (LOC729654) on chromosome 19","Q8NFU5",690,0,"Inositol polyphosphate multikinase",".",".",".",".","pfam03770","IPK","Inositol polyphosphate kinase. ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.","GO:0032958|inositol phosphate biosynthetic process;GO:0043647|inositol phosphate metabolic process;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000824|inositol tetrakisphosphate 3-kinase activity;GO:0047326|inositol tetrakisphosphate 5-kinase activity;GO:0000825|inositol tetrakisphosphate 6-kinase activity;GO:0008440|inositol-1,4,5-trisphosphate 3-kinase activity;GO:0000823|inositol-1,4,5-trisphosphate 6-kinase activity;","K00915","IPMK, IPK2; inositol-polyphosphate multikinase [EC:2.7.1.140 2.7.1.151]"]
["ENSG00000171658",420,380,363,211.851286186455,5,6,11,63.0189861277409,5.97771463882951,2.70922465282652e-73,1.1742814630049e-71,"up","yes","NMRAL2P","transcribed_unprocessed_pseudogene","chr3:185959943-185980872:+","gi|119598609|gb|EAW78203.1|",1088,3e-142,"hCG2041270, partial [Homo sapiens]","gi|694905501|ref|XM_009446977.1|",1599,0,"PREDICTED: Pan troglodytes putative nmrA-like family domain-containing protein ENSP00000305954 (LOC471029), mRNA","Q0VCN1",259,2e-79,"NmrA-like family domain-containing protein 1","mll7605",71.6,6e-13,"COG0702","pfam05368","NmrA","NmrA-like family. NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi. This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.",".","GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;",".","."]
["ENSG00000184106",12,5,11,5.019101699905,0,0,0,59.483228885932,5.89441105719511,3.29359594895353e-05,0.000134334697956049,"up","yes","TREML3P","transcribed_unprocessed_pseudogene","chr6:41208713-41217947:-","gi|27451953|gb|AAO15023.1|",672,1e-84,"TREM-like transcript 3 [Homo sapiens]","gi|224586781|ref|NR_027256.1|",978,0,"Homo sapiens triggering receptor expressed on myeloid cells like 3, pseudogene (TREML3P), non-coding RNA","Q6UXN2",175,1e-51,"Trem-like transcript 4 protein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0045087|innate immune response;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0050776|regulation of immune response;","GO:0005576|extracellular region;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000115009",34,25,30,16.2385456865489,0,1,1,53.2116068417184,5.73366906442171,2.26183314327498e-07,1.17464290973311e-06,"up","yes","CCL20","protein_coding","chr2:227805739-227817564:+","gi|194239688|ref|NP_001123518.1|",421,1e-48,"C-C motif chemokine 20 isoform 2 precursor [Homo sapiens]","gi|194239687|ref|NM_001130046.1|",839,0,"Homo sapiens C-C motif chemokine ligand 20 (CCL20), transcript variant 2, mRNA","P78556",162,3e-48,"C-C motif chemokine 20",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0060326|cell chemotaxis;GO:0007267|cell-cell signaling;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0071356|cellular response to tumor necrosis factor;GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0019221|cytokine-mediated signaling pathway;GO:0042742|defense response to bacterium;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0031640|killing of cells of other organism;GO:0048247|lymphocyte chemotaxis;GO:0002548|monocyte chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0043547|positive regulation of GTPase activity;GO:0050726|positive regulation of interleukin-1 alpha biosynthetic process;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:2000406|positive regulation of T cell migration;GO:0007165|signal transduction;GO:0072678|T cell migration;GO:0072679|thymocyte migration;GO:0042060|wound healing;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005622|intracellular;","GO:0031731|CCR6 chemokine receptor binding;GO:0008009|chemokine activity;","K14625","CCL20; C-C motif chemokine 20"]
["ENSG00000171903",409,432,391,225.996583801557,7,11,12,48.9797417560779,5.61411326225173,3.47035214401721e-84,1.81398786324672e-82,"up","yes","CYP4F11","protein_coding","chr19:15912367-15934867:-","gi|193083178|ref|NP_067010.3|",2615,0,"phylloquinone omega-hydroxylase CYP4F11 precursor [Homo sapiens]","gi|193083177|ref|NM_021187.3|",3158,0,"Homo sapiens cytochrome P450 family 4 subfamily F member 11 (CYP4F11), transcript variant 1, mRNA","Q9HBI6",1011,0,"Phylloquinone omega-hydroxylase CYP4F11","AGc2890",154,1e-38,"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0007596|blood coagulation;GO:0006631|fatty acid metabolic process;GO:0006954|inflammatory response;GO:0042361|menaquinone catabolic process;GO:0055114|oxidation-reduction process;GO:0042376|phylloquinone catabolic process;GO:0042377|vitamin K catabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031090|organelle membrane;","GO:0005504|fatty acid binding;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016709|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;","K17729","CYP4F11; cytochrome P450, family 4, subfamily F, polypeptide 11 [EC:1.14.14.1 1.14.13.194]"]
["ENSG00000167723",13,12,17,7.71965245846412,0,0,1,46.126465709242,5.5275228496996,3.26297583923085e-05,0.000133142115479341,"up","yes","TRPV3","protein_coding","chr17:3510502-3557995:-","gi|219517783|gb|AAI43300.1|",3748,0,"TRPV3 protein [Homo sapiens]","gi|384551637|ref|NM_001258205.1|",5672,0,"Homo sapiens transient receptor potential cation channel subfamily V member 3 (TRPV3), transcript variant 1, mRNA","Q8NET8",1392,0,"Transient receptor potential cation channel subfamily V member 3",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0070588|calcium ion transmembrane transport;GO:0042636|negative regulation of hair cycle;GO:0090280|positive regulation of calcium ion import;GO:0009408|response to heat;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0005262|calcium channel activity;","K04972","TRPV3; transient receptor potential cation channel subfamily V member 3"]
["ENSG00000233030",6,11,4,3.76441260746393,0,0,0,44.6218407412312,5.47967812378699,0.00024242035676235,0.000876110893991421,"up","yes","AC243772.2","antisense","chr1:149785659-149793020:-","gi|530365833|ref|XP_005245759.1|",716,2e-83,"PREDICTED: uncharacterized protein LOC101927767 [Homo sapiens]","gi|551898154|tpe|HG492740.1|",3543,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000033450.1 (RP11-196G18.3 gene), antisense",".",".",".",".",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.",".",".",".",".","."]
["ENSG00000259092",7,11,2,3.55329698190813,0,0,0,42.1933754650207,5.39894460249323,0.000422925500081687,0.00147218679761335,"up","yes","TRAV30","TR_V_gene","chr14:22168429-22168988:+","gi|545686402|dbj|BAN84592.1|",590,4e-76,"T-cell receptor alpha chain, partial [Homo sapiens]","gi|902378316|dbj|AB977086.1|",334,2e-173,"Homo sapiens mRNA for T cell receptor alpha chain V-J-region, partial cds, isolate: E(2)-TRA21","A0A087WSZ9",231,9e-78,"T cell receptor alpha variable 30",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002250|adaptive immune response;","GO:0005886|plasma membrane;",".",".","."]
["ENSG00000187134",4495,4218,3962,2327.99324098618,84,108,168,42.0185442925378,5.39295427645293,0,0,"up","yes","AKR1C1","protein_coding","chr10:4963253-4983283:+","gi|5453543|ref|NP_001344.2|",1730,0,"aldo-keto reductase family 1 member C1 [Homo sapiens]","gi|27652648|emb|AL713867.6|",5584,0,"Human DNA sequence from clone RP11-69D4 on chromosome 10, complete sequence","Q04828",671,0,"Aldo-keto reductase family 1 member C1","slr0942",214,2e-59,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0015721|bile acid and bile salt transport;GO:0008206|bile acid metabolic process;GO:0071395|cellular response to jasmonic acid stimulus;GO:0042632|cholesterol homeostasis;GO:0044597|daunorubicin metabolic process;GO:0007586|digestion;GO:0044598|doxorubicin metabolic process;GO:0030855|epithelial cell differentiation;GO:0030299|intestinal cholesterol absorption;GO:0055114|oxidation-reduction process;GO:0042448|progesterone metabolic process;GO:0051260|protein homooligomerization;GO:0046683|response to organophosphorus;GO:0042574|retinal metabolic process;GO:0001523|retinoid metabolic process;GO:0006805|xenobiotic metabolic process;","GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0047006|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity;GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0004033|aldo-keto reductase (NADP) activity;GO:0047042|androsterone dehydrogenase (B-specific) activity;GO:0032052|bile acid binding;GO:0031406|carboxylic acid binding;GO:0047718|indanol dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0047115|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;","K00212","E1.3.1.20; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.20]"]
["ENSG00000163993",240,216,180,116.542776300989,7,2,9,41.9536657532203,5.39072496831618,4.47280232532335e-46,1.19324220263951e-44,"up","yes","S100P","protein_coding","chr4:6693069-6697170:+","gi|795272855|ref|XP_011857544.1|",423,5e-47,"PREDICTED: protein S100-P [Mandrillus leucophaeus]","gi|28376390|gb|AF539739.1|",1273,0,"Homo sapiens calcium-binding S100 protein mRNA, complete cds","P25815",147,2e-41,"Protein S100-P",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0043542|endothelial cell migration;GO:0043312|neutrophil degranulation;GO:0010033|response to organic substance;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031528|microvillus membrane;GO:0016604|nuclear body;GO:0005634|nucleus;GO:0034774|secretory granule lumen;","GO:0045296|cadherin binding;GO:0005509|calcium ion binding;GO:0048306|calcium-dependent protein binding;GO:0000287|magnesium ion binding;GO:0042803|protein homodimerization activity;GO:0050786|RAGE receptor binding;GO:0046914|transition metal ion binding;",".","."]
["ENSG00000224251",6,5,8,3.43717990561716,0,0,0,40.6558622977306,5.34539148896079,0.000383598449920195,0.00134304717772023,"up","yes","AL391427.1","antisense","chr10:4995488-4997380:+",".",".",".",".","gi|551868338|tpe|HG502615.1|",425,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000046538.2 (RP11-499O7.7 gene), antisense",".",".",".",".",".",".",".",".","pfam09687","PRESAN","Plasmodium RESA N-terminal. The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.",".",".",".",".","."]
["ENSG00000257097",7,3,7,3.05368414505416,0,0,0,36.1741981420697,5.17688913239679,0.000842255883522606,0.00279131125109691,"up","yes","CLIP1-AS1","lincRNA","chr12:122395542-122400857:+",".",".",".",".","gi|551875818|tpe|HG505279.1|",1745,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000401639.1 (RP11-450K4.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam11877","DUF3397","Protein of unknown function (DUF3397). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 114 to 128 amino acids in length.",".",".",".",".","."]
["ENSG00000181291",7,4,6,3.04492036097034,0,0,0,36.0942052616139,5.17369533334669,0.000791052176149483,0.0026352011007895,"up","yes","TMEM132E","protein_coding","chr17:34579487-34639318:+","gi|74709535|sp|Q6IEE7.1|T132E_HUMAN",4189,0,"RecName: Full=Transmembrane protein 132E; Flags: Precursor","gi|42627764|tpe|BN000149.1|",4357,0,"TPA_inf: Homo sapiens mRNA for hypothetical protein","Q6IEE7",1618,0,"Transmembrane protein 132E",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".","GO:0016021|integral component of membrane;",".","K17599","TMEM132; transmembrane protein 132"]
["ENSG00000235899",8,4,5,3.02371243858938,0,0,0,35.897612971513,5.16581600944669,0.000834737893579131,0.00276855722400376,"up","yes","LINC01564","antisense","chr6:53628380-53631394:+","gi|119624832|gb|EAX04427.1|",419,1e-49,"hCG2045718 [Homo sapiens]","gi|674274967|ref|NR_125841.1|",566,0,"Homo sapiens long intergenic non-protein coding RNA 1564 (LINC01564), long non-coding RNA",".",".",".",".",".",".",".",".","pfam13811","DUF4186","Domain of unknown function (DUF4186).",".",".",".",".","."]
["ENSG00000121552",65,61,73,37.0058484978404,4,0,3,33.7631426333548,5.07737728952922,1.86141721176675e-16,1.86509169769128e-15,"up","yes","CSTA","protein_coding","chr3:122325244-122341972:+","gi|671031184|ref|XP_008706392.1|",310,4e-31,"PREDICTED: cystatin-A isoform X1 [Ursus maritimus]","gi|315013553|ref|NG_027995.1|",726,0,"Homo sapiens cystatin A (CSTA), RefSeqGene on chromosome 3","P01040",117,2e-31,"Cystatin-A",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0098609|cell-cell adhesion;GO:0070268|cornification;GO:0030216|keratinocyte differentiation;GO:0010466|negative regulation of peptidase activity;GO:0045861|negative regulation of proteolysis;GO:0018149|peptide cross-linking;","GO:0001533|cornified envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005634|nucleus;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0002020|protease binding;GO:0030674|protein binding, bridging;GO:0005198|structural molecule activity;","K13907","CSTA_B; cystatin-A/B"]
["ENSG00000239873",8,5,2,2.63513324815588,0,0,0,31.3650264854049,4.97108487578394,0.00204160857117616,0.00631369987507549,"up","yes","GAPDHP27","processed_pseudogene","chr1:119558755-119559774:-","gi|795264447|ref|XP_011811659.1|",609,7e-107,"PREDICTED: glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [Colobus angolensis palliatus]","gi|426214466|ref|NG_009337.2|",1020,0,"Homo sapiens glyceraldehyde 3 phosphate dehydrogenase pseudogene 27 (GAPDHP27) on chromosome 1","P04406",237,7e-107,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",172,4e-68,"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.","GO:0061621|canonical glycolysis;GO:0071346|cellular response to interferon-gamma;GO:0050832|defense response to fungus;GO:0006094|gluconeogenesis;GO:0051873|killing by host of symbiont cells;GO:0031640|killing of cells of other organism;GO:0000226|microtubule cytoskeleton organization;GO:0010951|negative regulation of endopeptidase activity;GO:0017148|negative regulation of translation;GO:0051402|neuron apoptotic process;GO:0035606|peptidyl-cysteine S-trans-nitrosylation;GO:0052501|positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction;GO:0050715|positive regulation of cytokine secretion;GO:0050821|protein stabilization;GO:0016241|regulation of macroautophagy;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0097452|GAIT complex;GO:0043231|intracellular membrane-bounded organelle;GO:0005811|lipid particle;GO:0016020|membrane;GO:0015630|microtubule cytoskeleton;GO:0031965|nuclear membrane;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0031982|vesicle;","GO:0019828|aspartic-type endopeptidase inhibitor activity;GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0042802|identical protein binding;GO:0008017|microtubule binding;GO:0051287|NAD binding;GO:0050661|NADP binding;GO:0035605|peptidyl-cysteine S-nitrosylase activity;","K00134","GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]"]
["ENSG00000137491",23,23,17,11.8404330823389,3,0,0,24.1199295926495,4.59215379082836,2.16480657890711e-06,1.01816116298367e-05,"up","yes","SLCO2B1","protein_coding","chr11:75100563-75206549:+","gi|194382160|dbj|BAG58835.1|",491,6e-52,"unnamed protein product [Homo sapiens]","gi|34534138|dbj|AK127289.1|",5860,0,"Homo sapiens cDNA FLJ45356 fis, clone BRHIP3012868, highly  similar to Homo sapiens solute carrier family 21 (organic anion transporter), member 9 (SLC21A9)","O94956",196,5e-50,"Solute carrier organic anion transporter family member 2B1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0015721|bile acid and bile salt transport;GO:0043252|sodium-independent organic anion transport;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015125|bile acid transmembrane transporter activity;GO:0008514|organic anion transmembrane transporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K14352","SLCO2B; solute carrier organic anion transporter family, member 2B"]
["ENSG00000197405",59,55,48,30.3318736931584,3,4,1,23.8049966025223,4.57319251787846,1.71346416582274e-14,1.54725172426915e-13,"up","yes","C5AR1","protein_coding","chr19:47290023-47322066:+","gi|311033355|sp|P21730.2|C5AR1_HUMAN",1662,0,"RecName: Full=C5a anaphylatoxin chemotactic receptor 1; AltName: Full=C5a anaphylatoxin chemotactic receptor; Short=C5a-R; Short=C5aR; AltName: CD_antigen=CD88","gi|112293258|ref|NM_001736.3|",2302,0,"Homo sapiens complement component 5a receptor 1 (C5AR1), mRNA","P21730",644,0,"C5a anaphylatoxin chemotactic receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000187|activation of MAPK activity;GO:0007202|activation of phospholipase C activity;GO:0031100|organ regeneration;GO:0006915|apoptotic process;GO:0060326|cell chemotaxis;GO:0021534|cell proliferation in hindbrain;GO:0006968|cellular defense response;GO:0006935|chemotaxis;GO:0038178|complement component C5a signaling pathway;GO:0050830|defense response to Gram-positive bacterium;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0050900|leukocyte migration;GO:0042789|mRNA transcription from RNA polymerase II promoter;GO:0043524|negative regulation of neuron apoptotic process;GO:0030593|neutrophil chemotaxis;GO:0043312|neutrophil degranulation;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0050679|positive regulation of epithelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0010759|positive regulation of macrophage chemotaxis;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0030449|regulation of complement activation;GO:0032496|response to lipopolysaccharide;GO:0032494|response to peptidoglycan;GO:0007606|sensory perception of chemical stimulus;GO:0007165|signal transduction;","GO:0045177|apical part of cell;GO:0016323|basolateral plasma membrane;GO:0009986|cell surface;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;","GO:0001856|complement component C5a binding;GO:0004878|complement component C5a receptor activity;GO:0004930|G-protein coupled receptor activity;","K04010","C5AR1; C5a anaphylatoxin chemotactic receptor"]
["ENSG00000279484",25,24,10,10.893476418773,0,2,1,23.3325515268997,4.54427217648834,5.46870676887823e-06,2.45760522269626e-05,"up","yes","KLHL30-AS1","TEC","chr2:238152889-238155994:-","gi|119591548|gb|EAW71142.1|",534,1e-59,"chromosome 2 open reading frame 19, partial [Homo sapiens]","gi|767921944|ref|XR_924047.1|",3106,0,"PREDICTED: Homo sapiens uncharacterized LOC105369287 (LOC105369287), ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSG00000176046",192,164,166,98.1973160891846,7,14,9,20.6501381975623,4.3680795315573,2.18902210199168e-43,5.48335822119682e-42,"up","yes","NUPR1","protein_coding","chr16:28532708-28539174:-","gi|355564363|gb|EHH20863.1|",348,2e-34,"hypothetical protein EGK_03802, partial [Macaca mulatta]","gi|29294021|gb|AC020765.8|",4964,0,"Homo sapiens chromosome 16 clone RP11-666O2, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000250644",19,6,6,5.708529635715,0,1,1,18.3646161875505,4.19885683957639,0.00100163168610218,0.00327670827027457,"up","yes","AC068580.4","protein_coding","chr11:1734821-1763954:-","gi|4503143|ref|NP_001900.1|",1709,0,"cathepsin D preproprotein [Homo sapiens]","gi|27884980|gb|AC068580.23|",2441,0,"Homo sapiens chromosome 11, clone RP11-295K3, complete sequence","P07339",662,0,"Cathepsin D",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006914|autophagy;GO:0030574|collagen catabolic process;GO:0043312|neutrophil degranulation;GO:0030163|protein catabolic process;GO:0006508|proteolysis;","GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043202|lysosomal lumen;GO:0005764|lysosome;GO:0042470|melanosome;GO:0045121|membrane raft;GO:0035580|specific granule lumen;","GO:0004190|aspartic-type endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0004252|serine-type endopeptidase activity;","K01379","CTSD; cathepsin D [EC:3.4.23.5]"]
["ENSG00000174343",10,3,4,3.11445770299032,0,0,1,18.271497474578,4.19152297245514,0.00654470515819811,0.0181501471015564,"up","yes","CHRNA9","protein_coding","chr4:40335329-40355217:+","gi|70995130|ref|NP_060051.2|",2467,0,"neuronal acetylcholine receptor subunit alpha-9 precursor [Homo sapiens]","gi|375268712|ref|NM_017581.3|",2276,0,"Homo sapiens cholinergic receptor nicotinic alpha 9 subunit (CHRNA9), mRNA","Q9UGM1",954,0,"Neuronal acetylcholine receptor subunit alpha-9",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0042472|inner ear morphogenesis;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0007204|positive regulation of cytosolic calcium ion concentration;","GO:0005892|acetylcholine-gated channel complex;GO:0030054|cell junction;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;","GO:0022848|acetylcholine-gated cation channel activity;GO:0005262|calcium channel activity;GO:0015276|ligand-gated ion channel activity;GO:0004888|transmembrane signaling receptor activity;","K04810","CHRNA9; nicotinic acetylcholine receptor alpha-9"]
["ENSG00000156510",157,192,167,98.112612805925,6,14,15,17.690854243322,4.14493180842444,6.65519509641797e-42,1.62487851923683e-40,"up","yes","HKDC1","protein_coding","chr10:69220303-69267559:+","gi|311033440|sp|Q2TB90.3|HKDC1_HUMAN",4799,0,"RecName: Full=Putative hexokinase HKDC1; AltName: Full=Hexokinase domain-containing protein 1","gi|156151419|ref|NM_025130.3|",3683,0,"Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA","Q2TB90",1853,0,"Putative hexokinase HKDC1","SPAC24H6.04",278,5e-81,"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.","GO:0001678|cellular glucose homeostasis;GO:0006096|glycolytic process;GO:0019318|hexose metabolic process;","GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0008865|fructokinase activity;GO:0004340|glucokinase activity;GO:0005536|glucose binding;GO:0019158|mannokinase activity;","K00844","HK; hexokinase [EC:2.7.1.1]"]
["ENSG00000228307",4,6,6,3.08964120044195,1,0,0,17.6067057056036,4.13805309452875,0.00669907885192709,0.0185329651313783,"up","yes","OR2S1P","transcribed_unprocessed_pseudogene","chr9:35962195-36014623:+","gi|795261891|ref|XP_011856003.1|",1138,2e-148,"PREDICTED: olfactory receptor 2S2-like [Mandrillus leucophaeus]","gi|14494868|emb|AL138834.28|",1589,0,"Human DNA sequence from clone RP11-113A10 on chromosome 9, complete sequence","P0DN81",410,3e-137,"Olfactory receptor 13C7",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0004984|olfactory receptor activity;",".","."]
["ENSG00000267456",9,3,4,2.97388733907436,0,1,0,17.2325416822124,4.10706359981011,0.00810189055729164,0.021981891274306,"up","yes","AC023043.3","processed_pseudogene","chr18:36278735-36279119:-","gi|929074895|ref|XP_014047728.1|",104,2e-09,"PREDICTED: ras-related protein R-Ras [Salmo salar]","gi|21930268|gb|AC023043.8|",385,0,"Homo sapiens chromosome 18, clone RP11-49I11, complete sequence","P22278",45.1,4e-10,"Ras-like protein 1","SPAC17H9.09c",40,4e-08,"COG1100","pfam10996","Beta-Casp","Beta-Casp domain. The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains.","GO:0007165|signal transduction;","GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;",".","."]
["ENSG00000274290",10,2,4,2.99744880249149,1,0,0,17.170173219019,4.10183268873872,0.00885817614237375,0.0238260356204302,"up","yes","HIST1H2BE","protein_coding","chr6:26172059-26184655:+","gi|297290242|ref|XP_001086637.2|",531,8e-60,"PREDICTED: histone H2B type 1-like [Macaca mulatta]","gi|8745068|emb|AL353759.8|",1352,0,"Human DNA sequence from clone RP1-221C16 on chromosome 6, complete sequence","Q99877",188,3e-54,"Histone H2B type 1-N",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;GO:0016567|protein ubiquitination;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["ENSG00000243742",141,125,146,78.3212961546861,5,4,21,16.7061772617314,4.06230974591208,3.23854796200835e-32,6.18466466249673e-31,"up","yes","RPLP0P2","transcribed_processed_pseudogene","chr11:61615036-61639449:+","gi|154757503|gb|AAI51696.1|",1235,2e-156,"RPLP0 protein [Bos taurus]","gi|224586941|ref|NR_002775.2|",3525,0,"Homo sapiens ribosomal protein lateral stalk subunit P0 pseudogene 2 (RPLP0P2), non-coding RNA","P05388",463,2e-151,"60S acidic ribosomal protein P0","SPCC18.14c",253,1e-74,"COG0244","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0035722|interleukin-12-mediated signaling pathway;GO:0000184|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042254|ribosome biogenesis;GO:0006614|SRP-dependent cotranslational protein targeting to membrane;GO:0006412|translation;GO:0006413|translational initiation;GO:0016032|viral process;","GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0005829|cytosol;GO:0022625|cytosolic large ribosomal subunit;GO:0005783|endoplasmic reticulum;GO:0070062|extracellular exosome;GO:0005925|focal adhesion;GO:0016020|membrane;GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;","K02941","RP-LP0, RPLP0; large subunit ribosomal protein LP0"]
["ENSG00000236501",7,1,7,2.87992865054334,1,0,0,16.3719844660714,4.03315729793588,0.0114003442836761,0.0299332753258297,"up","yes","AC074286.1","lincRNA","chr2:176990508-177164516:-","gi|355692940|gb|EHH27543.1|",159,2e-11,"hypothetical protein EGK_17760, partial [Macaca mulatta]","gi|551847786|tpe|HG494934.1|",567,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000339665.1 (AC079305.11 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000155980",6,3,5,2.65769569986754,0,1,0,15.2503873004376,3.93077397686292,0.0125739238353691,0.0327251171146403,"up","yes","KIF5A","protein_coding","chr12:57549998-57586632:+","gi|45446749|ref|NP_004975.2|",4743,0,"kinesin heavy chain isoform 5A [Homo sapiens]","gi|166788559|dbj|AB290174.1|",5806,0,"Homo sapiens mRNA for KIF5A variant protein, complete cds","Q12840",1831,0,"Kinesin heavy chain isoform 5A","SPAC1834.07",322,1e-94,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007411|axon guidance;GO:0007268|synaptic transmission;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0007018|microtubule-based movement;GO:0008104|protein localization;GO:1990049|retrograde dense core granule transport;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:0016192|vesicle-mediated transport;","GO:1904115|axon cytoplasm;GO:0035253|ciliary rootlet;GO:0005829|cytosol;GO:0032839|dendrite cytoplasm;GO:0005871|kinesin complex;GO:0016020|membrane;GO:0005874|microtubule;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0019894|kinesin binding;GO:0008017|microtubule binding;GO:0003774|motor activity;","K10396","KIF5; kinesin family member 5"]
["ENSG00000155380",175,150,160,93.0019453125673,11,13,15,14.787465973366,3.88630294374913,1.12012514831853e-40,2.67057773309862e-39,"up","yes","SLC16A1","protein_coding","chr1:112911847-112957013:-","gi|115583685|ref|NP_003042.3|",2459,0,"monocarboxylate transporter 1 [Homo sapiens]","gi|262073006|ref|NM_001166496.1|",4374,0,"Homo sapiens solute carrier family 16 member 1 (SLC16A1), transcript variant 2, mRNA","P53985",951,0,"Monocarboxylate transporter 1",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0051780|behavioral response to nutrient;GO:0071407|cellular response to organic cyclic compound;GO:0007098|centrosome cycle;GO:0042593|glucose homeostasis;GO:0050900|leukocyte migration;GO:0006629|lipid metabolic process;GO:0015728|mevalonate transport;GO:0015718|monocarboxylic acid transport;GO:0035879|plasma membrane lactate transport;GO:0006090|pyruvate metabolic process;GO:0050796|regulation of insulin secretion;GO:0032094|response to food;","GO:0030054|cell junction;GO:0005813|centrosome;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0015129|lactate transmembrane transporter activity;GO:0015130|mevalonate transmembrane transporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0097159|organic cyclic compound binding;GO:0042803|protein homodimerization activity;GO:0015293|symporter activity;","K08179","SLC16A1; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 1"]
["ENSG00000138061",13382,12044,12038,7184.46489669612,847,982,1203,14.6880128473707,3.87656732065463,0,0,"up","yes","CYP1B1","protein_coding","chr2:38066973-38109902:-","gi|189491763|ref|NP_000095.2|",2659,0,"cytochrome P450 1B1 [Homo sapiens]","gi|189491762|ref|NM_000104.3|",5154,0,"Homo sapiens cytochrome P450 family 1 subfamily B member 1 (CYP1B1), mRNA","Q16678",1026,0,"Cytochrome P450 1B1",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001525|angiogenesis;GO:0019369|arachidonic acid metabolic process;GO:0048514|blood vessel morphogenesis;GO:0007155|cell adhesion;GO:0006725|cellular aromatic compound metabolic process;GO:0070301|cellular response to hydrogen peroxide;GO:0071407|cellular response to organic cyclic compound;GO:0030199|collagen fibril organization;GO:0043542|endothelial cell migration;GO:0071603|endothelial cell-cell adhesion;GO:0019373|epoxygenase P450 pathway;GO:0008210|estrogen metabolic process;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0046466|membrane lipid catabolic process;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0006809|nitric oxide biosynthetic process;GO:0097267|omega-hydroxylase P450 pathway;GO:0055114|oxidation-reduction process;GO:0045766|positive regulation of angiogenesis;GO:0043065|positive regulation of apoptotic process;GO:0046427|positive regulation of JAK-STAT cascade;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:2000377|regulation of reactive oxygen species metabolic process;GO:0061304|retinal blood vessel morphogenesis;GO:0042574|retinal metabolic process;GO:0042572|retinol metabolic process;GO:0008202|steroid metabolic process;GO:0016125|sterol metabolic process;GO:0009404|toxin metabolic process;GO:0002930|trabecular meshwork development;GO:0007601|visual perception;GO:0006805|xenobiotic metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0031090|organelle membrane;","GO:0070330|aromatase activity;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019825|oxygen binding;","K07410","CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [EC:1.14.14.1]"]
["ENSG00000163734",656,654,610,369.014463228742,47,53,57,14.5232386293001,3.86029129983486,2.57827813759244e-151,3.06974251344956e-149,"up","yes","CXCL3","protein_coding","chr4:74036589-74038807:-","gi|966943489|ref|XP_001092240.2|",301,6e-36,"PREDICTED: uncharacterized protein LOC702067 [Macaca mulatta]","gi|164696131|dbj|AK311367.1|",1632,0,"Homo sapiens cDNA, FLJ18409","P19876",95.1,1e-29,"C-X-C motif chemokine 3",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0070098|chemokine-mediated signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0031640|killing of cells of other organism;GO:0030593|neutrophil chemotaxis;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0042127|regulation of cell proliferation;GO:0032496|response to lipopolysaccharide;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSG00000214814",1,6,6,2.54753625634602,0,1,0,14.4895351602728,3.85693940733043,0.0181708484058347,0.0452581771761026,"up","yes","FER1L6","protein_coding","chr8:123851987-124120061:+","gi|767953453|ref|XP_011515533.1|",9207,0,"PREDICTED: fer-1-like protein 6 isoform X2 [Homo sapiens]","gi|119120883|ref|NM_001039112.2|",6051,0,"Homo sapiens fer-1 like family member 6 (FER1L6), mRNA","Q2WGJ9",3540,0,"Fer-1-like protein 6",".",".",".",".","pfam08151","FerI","FerI (NUC094) domain. This domain is present in proteins of the Ferlin family. It is often located between two C2 domains.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000256564",4,3,6,2.48207442457669,0,0,1,14.3070567400955,3.83865500502274,0.0164912558476864,0.0416339453913843,"up","yes","AC007552.2","antisense","chr12:16567411-16573940:+",".",".",".",".","gi|578823112|ref|XR_429051.1|",603,0,"PREDICTED: Homo sapiens uncharacterized LOC102724196 (LOC102724196), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam05526","R_equi_Vir","Rhodococcus equi virulence-associated protein. This family consists of several virulence-associated proteins from Rhodococcus equi. Rhodococcus equi is an important pulmonary pathogen of foals and is increasingly isolated from pneumonic infections and other infections in human immunodeficiency virus (HIV)-infected patients. Isolates from foals possess a large virulence plasmid, varying in size from 80 to 90 kb. Isolates lacking the plasmid are avirulent to foals. Little is known about the function of the plasmid apart from its encoding a virulence associated surface proteins.",".",".",".",".","."]
["ENSG00000231683",7,4,2,2.4738218919422,1,0,0,13.9712474968384,3.80438894005489,0.01838264565249,0.0456912975960345,"up","yes","AL033397.1","lincRNA","chr6:53561289-53617171:-","gi|119629143|gb|EAX08738.1|",223,1e-17,"hCG1741841 [Homo sapiens]","gi|551859347|tpe|HG499276.1|",3653,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000359959.1 (RP1-27K12.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam07127","Nodulin_late","Late nodulin protein. This family consists of several plant specific late nodulin sequences which are homologous to the Pisum sativum (Garden pea) ENOD3 protein. ENOD3 is expressed in the late stages of root nodule formation and contains two pairs of cysteine residues towards the C-terminus which may be involved in metal-binding.",".",".",".",".","."]
["ENSG00000226744",55,30,32,22.2386073717614,1,5,4,13.9249918033864,3.79960457324497,1.96035834551059e-10,1.34992473288855e-09,"up","yes","AC005326.1","processed_pseudogene","chr7:97870167-97870289:+","gi|593721435|ref|XP_007106976.1|",227,6e-21,"PREDICTED: asparagine synthetase [glutamine-hydrolyzing]-like isoform X3 [Physeter catodon]","gi|568786344|ref|NG_033870.1|",123,1e-56,"Homo sapiens asparagine synthetase (glutamine-hydrolyzing) (ASNS), RefSeqGene on chromosome 7","P49088",92,3e-22,"Asparagine synthetase [glutamine-hydrolyzing]",".",".",".",".","pfam14070","YjfB_motility","Putative motility protein. This family of proteins is regulated in B. subtilis by SigD, and is likely to be involved in motility or flagellin production, Proteins in this family are approximately 60 amino acids in length, and contain two highly conserved asparagine residues.","GO:0006529|asparagine biosynthetic process;GO:0006520|cellular amino acid metabolic process;GO:0042149|cellular response to glucose starvation;GO:0032870|cellular response to hormone stimulus;GO:0006541|glutamine metabolic process;GO:0070981|L-asparagine biosynthetic process;GO:0001889|liver development;GO:0043066|negative regulation of apoptotic process;GO:0045931|positive regulation of mitotic cell cycle;GO:0043200|response to amino acid;GO:0032354|response to follicle-stimulating hormone;GO:0009416|response to light stimulus;GO:0009612|response to mechanical stimulus;GO:0031427|response to methotrexate;GO:0031667|response to nutrient levels;GO:0009636|response to toxic substance;","GO:0005829|cytosol;","GO:0004066|asparagine synthase (glutamine-hydrolyzing) activity;GO:0005524|ATP binding;GO:0048037|cofactor binding;GO:0042803|protein homodimerization activity;","K01953","asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]"]
["ENSG00000235848",26,24,20,13.4705914285732,3,0,3,13.7855997934603,3.7850901333799,5.12683547680529e-07,2.57382620189017e-06,"up","yes","RMDN2-AS1","antisense","chr2:37949911-38067041:-","gi|426335303|ref|XP_004029167.1|",168,4e-10,"PREDICTED: uncharacterized protein LOC101133936 [Gorilla gorilla gorilla]","gi|19033957|gb|AC016689.4|",629,0,"Homo sapiens BAC clone RP11-81H20 from 2, complete sequence",".",".",".",".",".",".",".",".","pfam03402","V1R","Vomeronasal organ pheromone receptor family, V1R. This family represents one of two known vomeronasal organ receptor families, the V1R family.",".",".",".",".","."]
["ENSG00000182264",47,26,38,21.4602791221576,3,6,1,12.944619003483,3.69428059818065,8.57880741924444e-10,5.59202559994548e-09,"up","yes","IZUMO1","protein_coding","chr19:48740852-48746909:-","gi|768008360|ref|XP_011525113.1|",521,5e-56,"PREDICTED: izumo sperm-egg fusion protein 1 isoform X3 [Homo sapiens]","gi|29791966|gb|BC050460.1|",2169,0,"Homo sapiens izumo sperm-egg fusion 1, mRNA (cDNA clone IMAGE:6190065), with apparent retained intron","Q8IYV9",135,5e-33,"Izumo sperm-egg fusion protein 1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007155|cell adhesion;GO:0007342|fusion of sperm to egg plasma membrane;GO:0034113|heterotypic cell-cell adhesion;GO:0007338|single fertilization;GO:0035036|sperm-egg recognition;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0042802|identical protein binding;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0042803|protein homodimerization activity;GO:0005102|receptor binding;",".","."]
["ENSG00000188451",10,5,7,4.26313041124604,1,1,0,12.6490877064283,3.66096143167466,0.00496568482591465,0.014130736046362,"up","yes","SRP72P2","processed_pseudogene","chr6:158237336-158242797:-","gi|795244738|ref|XP_011853826.1|",1493,0,"PREDICTED: LOW QUALITY PROTEIN: signal recognition particle subunit SRP72 [Mandrillus leucophaeus]","gi|625282800|ref|XM_007634884.1|",1166,0,"PREDICTED: Cricetulus griseus signal recognition particle 72kDa (Srp72), transcript variant X2, mRNA","O76094",570,0,"Signal recognition particle subunit SRP72",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0042493|response to drug;GO:0006614|SRP-dependent cotranslational protein targeting to membrane;GO:0006616|SRP-dependent cotranslational protein targeting to membrane, translocation;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0048500|signal recognition particle;GO:0005786|signal recognition particle, endoplasmic reticulum targeting;","GO:0008312|7S RNA binding;GO:0003723|RNA binding;GO:0005047|signal recognition particle binding;GO:0030911|TPR domain binding;","K03108","SRP72; signal recognition particle subunit SRP72"]
["ENSG00000139269",162,159,153,91.8280440454384,11,12,22,12.6178725000202,3.65739677284523,6.58633488781223e-39,1.48929926513625e-37,"up","yes","INHBE","protein_coding","chr12:57452323-57459280:+","gi|13899338|ref|NP_113667.1|",1654,0,"inhibin beta E chain precursor [Homo sapiens]","gi|33870310|gb|BC005161.2|",2429,0,"Homo sapiens inhibin, beta E, mRNA (cDNA clone MGC:4638 IMAGE:3529092), complete cds","P58166",641,0,"Inhibin beta E chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0048468|cell development;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0005160|transforming growth factor beta receptor binding;","K04667","INHB; inhibin, beta"]
["ENSG00000132837",33,21,19,13.9345309536187,0,3,4,12.5955078293624,3.65483738513206,4.79778685097936e-07,2.41744286263558e-06,"up","yes","DMGDH","protein_coding","chr5:78997606-79236038:-","gi|24797151|ref|NP_037523.2|",4492,0,"dimethylglycine dehydrogenase, mitochondrial precursor [Homo sapiens]","gi|526253061|ref|NM_013391.3|",3106,0,"Homo sapiens dimethylglycine dehydrogenase (DMGDH), transcript variant 1, mRNA","Q9UI17",1734,0,"Dimethylglycine dehydrogenase, mitochondrial","SMa1483_1",348,2e-108,"COG0665","pfam01571","GCV_T","Aminomethyltransferase folate-binding domain. This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.","GO:0006579|amino-acid betaine catabolic process;GO:0042426|choline catabolic process;GO:0019695|choline metabolic process;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0047865|dimethylglycine dehydrogenase activity;GO:0009055|electron carrier activity;GO:0003723|RNA binding;","K00315","DMGDH; dimethylglycine dehydrogenase [EC:1.5.8.4]"]
["ENSG00000165495",23,12,16,9.74246128042218,0,1,4,12.5036398963169,3.64427622945092,2.74571883456947e-05,0.000113414061287052,"up","yes","PKNOX2","protein_coding","chr11:125164687-125433389:+","gi|829858422|ref|XP_012638738.1|",782,3e-89,"PREDICTED: homeobox protein PKNOX2, partial [Microcebus murinus]","gi|12224831|emb|AL512682.1|",4459,0,"Homo sapiens mRNA; cDNA DKFZp547B212 (from clone DKFZp547B212)","Q96KN3",304,3e-89,"Homeobox protein PKNOX2",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.",".","GO:0015629|actin cytoskeleton;GO:0005737|cytoplasm;GO:0045171|intercellular bridge;GO:0015630|microtubule cytoskeleton;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051015|actin filament binding;GO:0003785|actin monomer binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000257743",28,32,14,14.2623466809607,2,3,2,12.4212736509626,3.63474120690938,4.59747862041602e-07,2.32197349124337e-06,"up","yes","MGAM2","protein_coding","chr7:142111749-142222324:+","gi|651164871|ref|NP_001280555.1|",9687,0,"putative maltase-glucoamylase-like protein FLJ16351 [Homo sapiens]","gi|651164870|ref|NM_001293626.1|",7867,0,"Homo sapiens maltase-glucoamylase 2 (putative) (MGAM2), mRNA","Q2M2H8",3711,0,"Probable maltase-glucoamylase 2","lin0222",254,3e-69,"COG1501","pfam01055","Glyco_hydro_31","Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolizm. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.","GO:0005975|carbohydrate metabolic process;","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0004339|glucan 1,4-alpha-glucosidase activity;","K12047","MGAM; maltase-glucoamylase [EC:3.2.1.20 3.2.1.3]"]
["ENSG00000130513",4342,4454,4129,2514.71190910773,360,398,504,12.187562586433,3.60733772239821,0,0,"up","yes","GDF15","protein_coding","chr19:18374731-18389176:+","gi|153792495|ref|NP_004855.2|",1490,0,"growth/differentiation factor 15 preproprotein [Homo sapiens]","gi|153792494|ref|NM_004864.2|",1200,0,"Homo sapiens growth differentiation factor 15 (GDF15), mRNA","Q99988",578,0,"Growth/differentiation factor 15",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0000187|activation of MAPK activity;GO:0030509|BMP signaling pathway;GO:0048468|cell development;GO:0007267|cell-cell signaling;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0060400|negative regulation of growth hormone receptor signaling pathway;GO:0040015|negative regulation of multicellular organism growth;GO:0043410|positive regulation of MAPK cascade;GO:1901741|positive regulation of myoblast fusion;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0051897|positive regulation of protein kinase B signaling;GO:0002023|reduction of food intake in response to dietary excess;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0007165|signal transduction;GO:0060395|SMAD protein signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0005634|nucleus;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0042803|protein homodimerization activity;GO:0005160|transforming growth factor beta receptor binding;","K05504","GDF15; growth differentiation factor 15"]
["ENSG00000116183",21,28,30,15.3993992625678,1,1,6,12.1564755071521,3.60365310776521,1.73998928541516e-07,9.12973703402817e-07,"up","yes","PAPPA2","protein_coding","chr1:176463171-176845605:+","gi|116174738|ref|NP_064714.2|",9230,0,"pappalysin-2 isoform 1 precursor [Homo sapiens]","gi|767910113|ref|XM_011509857.1|",9563,0,"PREDICTED: Homo sapiens pappalysin 2 (PAPPA2), transcript variant X1, mRNA","Q9BXP8",3560,0,"Pappalysin-2",".",".",".",".","pfam13385","Laminin_G_3","Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.","GO:0060349|bone morphogenesis;GO:0044267|cellular protein metabolic process;GO:0006508|proteolysis;GO:0001558|regulation of cell growth;GO:0009651|response to salt stress;","GO:0016324|apical plasma membrane;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005622|intracellular;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08647","PAPPA2; pappalysin-2 [EC:3.4.24.-]"]
["ENSG00000152463",56,53,41,28.9807879217771,2,1,13,11.5235423186928,3.52651236201944,5.67375394822553e-12,4.37566438038281e-11,"up","yes","OLAH","protein_coding","chr10:15032227-15073852:+","gi|8922871|ref|NP_060794.1|",1685,0,"S-acyl fatty acid synthase thioesterase, medium chain isoform 1 [Homo sapiens]","gi|217416333|ref|NM_018324.2|",1767,0,"Homo sapiens oleoyl-ACP hydrolase (OLAH), transcript variant 1, mRNA","Q9NV23",518,0,"S-acyl fatty acid synthase thioesterase, medium chain","alr2045",107,5e-25,"COG3208","pfam00975","Thioesterase","Thioesterase domain. Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.","GO:0008610|lipid biosynthetic process;GO:0051792|medium-chain fatty acid biosynthetic process;","GO:0005829|cytosol;","GO:0047381|dodecanoyl-[acyl-carrier-protein] hydrolase activity;GO:0016295|myristoyl-[acyl-carrier-protein] hydrolase activity;GO:0004320|oleoyl-[acyl-carrier-protein] hydrolase activity;GO:0016296|palmitoyl-[acyl-carrier-protein] hydrolase activity;","K01071","MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]"]
["ENSG00000134321",73,73,61,40.5415577870074,8,6,8,11.1187656551558,3.47492473168726,1.35527937937214e-17,1.43866971212602e-16,"up","yes","RSAD2","protein_coding","chr2:6865806-6898239:+","gi|19923667|ref|NP_542388.2|",1796,0,"radical S-adenosyl methionine domain-containing protein 2 [Homo sapiens]","gi|90186265|ref|NM_080657.4|",3512,0,"Homo sapiens radical S-adenosyl methionine domain containing 2 (RSAD2), mRNA","Q8WXG1",696,0,"Radical S-adenosyl methionine domain-containing protein 2",".",".",".",".","pfam04055","Radical_SAM","Radical SAM superfamily. Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.","GO:0035710|CD4-positive, alpha-beta T cell activation;GO:0043367|CD4-positive, alpha-beta T cell differentiation;GO:0051607|defense response to virus;GO:0050709|negative regulation of protein secretion;GO:0045071|negative regulation of viral genome replication;GO:2000553|positive regulation of T-helper 2 cell cytokine production;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0009615|response to virus;GO:0060337|type I interferon signaling pathway;GO:0016032|viral process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0001650|fibrillar center;GO:0005794|Golgi apparatus;GO:0005811|lipid particle;GO:0005743|mitochondrial inner membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0003824|catalytic activity;GO:0046872|metal ion binding;GO:0043621|protein self-association;","K15045","RSAD2; radical S-adenosyl methionine domain-containing protein 2"]
["ENSG00000236404",163,161,157,94.4266399858705,15,14,24,10.8379875623962,3.43802499149748,2.11104801738914e-38,4.71818008799556e-37,"up","yes","VLDLR-AS1","antisense","chr9:2421597-2643359:-","gi|193787328|dbj|BAG52534.1|",564,2e-63,"unnamed protein product [Homo sapiens]","gi|9863651|emb|AL353667.10|",2914,0,"Human DNA sequence from clone RP11-125B21 on chromosome 9p24.1-24.3, complete sequence","Q6UX73",68.9,1e-10,"UPF0764 protein C16orf89",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000139988",5,10,3,3.53759087315443,1,0,1,10.6270407678864,3.40966801124315,0.013272450637271,0.0343530633241659,"up","yes","RDH12","protein_coding","chr14:67701886-67734452:+","gi|186928839|ref|NP_689656.2|",1536,0,"retinol dehydrogenase 12 precursor [Homo sapiens]","gi|186928838|ref|NM_152443.2|",1878,0,"Homo sapiens retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12), mRNA","Q96NR8",588,0,"Retinol dehydrogenase 12",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0045494|photoreceptor cell maintenance;GO:0050896|response to stimulus;GO:0001523|retinoid metabolic process;GO:0042572|retinol metabolic process;GO:0007601|visual perception;","GO:0005622|intracellular;GO:0060342|photoreceptor inner segment membrane;","GO:0052650|NADP-retinol dehydrogenase activity;GO:0004745|retinol dehydrogenase activity;","K11153","RDH12; retinol dehydrogenase 12 [EC:1.1.1.300]"]
["ENSG00000227726",2,6,9,3.41035647174346,0,1,1,10.5413579174216,3.39798881902981,0.0158009889743593,0.0401170824453656,"up","yes","AP001271.1","sense_intronic","chr11:70477277-70477592:-",".",".",".",".","gi|551871403|tpe|HG503947.1|",206,2e-102,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000327645.1 (AP001271.3 gene), sense_intronic",".",".",".",".",".",".",".",".","pfam12725","DUF3810","Protein of unknown function (DUF3810). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 333 and 377 amino acids in length. There is a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterized family of peptidase enzymes.",".",".",".",".","."]
["ENSG00000144619",17,26,20,12.551496232201,3,4,0,10.4143872662932,3.38050605535239,5.29412633749563e-06,2.38359264233463e-05,"up","yes","CNTN4","protein_coding","chr3:2098813-3057956:+","gi|28373122|ref|NP_783200.1|",5346,0,"contactin-4 isoform a precursor [Homo sapiens]","gi|332688244|ref|NM_001206955.1|",5198,0,"Homo sapiens contactin 4 (CNTN4), transcript variant 4, mRNA","Q8IWV2",2063,0,"Contactin-4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0007409|axonogenesis;GO:0007420|brain development;GO:0045665|negative regulation of neuron differentiation;GO:0007399|nervous system development;GO:0007158|neuron cell-cell adhesion;GO:0031175|neuron projection development;GO:0048167|regulation of synaptic plasticity;","GO:0031225|anchored component of membrane;GO:0030424|axon;GO:0005576|extracellular region;GO:0005886|plasma membrane;",".","K06762","CNTN4; contactin 4"]
["ENSG00000241322",40,55,30,24.586896661317,4,2,9,10.037286822966,3.32729744225977,2.91770051446866e-10,1.97947968776192e-09,"up","yes","CDRT1","protein_coding","chr17:15565483-15619512:-","gi|389885061|ref|NP_001254514.1|",4895,0,"F-box/WD repeat-containing protein 10 isoform 1 [Homo sapiens]","gi|543173105|ref|NM_001282540.1|",3016,0,"Homo sapiens CMT1A duplicated region transcript 1 (CDRT1), transcript variant 2, mRNA","Q5XX13",1890,0,"F-box/WD repeat-containing protein 10",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;","GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;","K10266","FBXW10; F-box and WD-40 domain protein 10"]
["ENSG00000255150",37,36,26,19.3700938462487,1,4,7,9.99917419294097,3.32180895119293,8.66866888208073e-09,5.1383308358197e-08,"up","yes","EID3","protein_coding","chr12:104303739-104305205:+","gi|635067736|ref|XP_008002670.1|",1846,0,"PREDICTED: thioredoxin reductase 1, cytoplasmic isoform X5 [Chlorocebus sabaeus]","gi|342675615|ref|NG_029392.1|",1467,0,"Homo sapiens thioredoxin reductase 1 (TXNRD1), RefSeqGene on chromosome 12","A5LFW4",704,0,"EP300-interacting inhibitor of differentiation 3","ECU08g1820",63.5,2e-10,"COG5125","pfam08743","Nse4_C","Nse4 C-terminal. Nse4 is a component of the Smc5/6 DNA repair complex. It forms interactions with Smc5 and Nse1. The exact function of this highly conserved C-terminal domain is not known.","GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0000781|chromosome, telomeric region;GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0030915|Smc5-Smc6 complex;",".",".","."]
["ENSG00000248323",2941,2758,2659,1651.66966146478,252,392,351,9.96996558737568,3.31758852498374,0,0,"up","yes","LUCAT1","antisense","chr5:91054834-91314547:-","gi|21756629|dbj|BAC04924.1|",304,1e-28,"unnamed protein product [Homo sapiens]","gi|551856705|tpe|HG498234.1|",2672,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000369757.1 (RP11-213H15.3 gene), lincRNA","Q8WTZ3",110,4e-25,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000073756",2755,2613,2618,1584.08015237835,280,331,366,9.70650053815419,3.27895125792753,0,0,"up","yes","PTGS2","protein_coding","chr1:186671791-186680427:-","gi|4506265|ref|NP_000954.1|",3103,0,"prostaglandin G/H synthase 2 precursor [Homo sapiens]","gi|574956975|ref|NM_000963.3|",4494,0,"Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2), mRNA","P35354",1198,0,"Prostaglandin G/H synthase 2",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0007568|aging;GO:0001525|angiogenesis;GO:0030282|bone mineralization;GO:0050873|brown fat cell differentiation;GO:0071318|cellular response to ATP;GO:0071498|cellular response to fluid shear stress;GO:0034605|cellular response to heat;GO:0071456|cellular response to hypoxia;GO:0071284|cellular response to lead ion;GO:0071260|cellular response to mechanical stimulus;GO:0071471|cellular response to non-ionic osmotic stress;GO:0034644|cellular response to UV;GO:0019371|cyclooxygenase pathway;GO:0019221|cytokine-mediated signaling pathway;GO:0046697|decidualization;GO:0007566|embryo implantation;GO:0042633|hair cycle;GO:0006954|inflammatory response;GO:0007612|learning;GO:0019372|lipoxygenase pathway;GO:0042759|long-chain fatty acid biosynthetic process;GO:0035633|maintenance of blood-brain barrier;GO:0007613|memory;GO:0034356|NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0051926|negative regulation of calcium ion transport;GO:0045786|negative regulation of cell cycle;GO:0008285|negative regulation of cell proliferation;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1902219|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0045986|negative regulation of smooth muscle contraction;GO:0032227|negative regulation of synaptic transmission, dopaminergic;GO:0030728|ovulation;GO:0043065|positive regulation of apoptotic process;GO:0090336|positive regulation of brown fat cell differentiation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0031622|positive regulation of fever generation;GO:0090271|positive regulation of fibroblast growth factor production;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0090362|positive regulation of platelet-derived growth factor production;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0042307|positive regulation of protein import into nucleus;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045987|positive regulation of smooth muscle contraction;GO:0031915|positive regulation of synaptic plasticity;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0071636|positive regulation of transforming growth factor beta production;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0045907|positive regulation of vasoconstriction;GO:0001516|prostaglandin biosynthetic process;GO:0008217|regulation of blood pressure;GO:0050727|regulation of inflammatory response;GO:1990776|response to angiotensin;GO:0032355|response to estradiol;GO:0070542|response to fatty acid;GO:0009750|response to fructose;GO:0051384|response to glucocorticoid;GO:0032496|response to lipopolysaccharide;GO:0010226|response to lithium ion;GO:0010042|response to manganese ion;GO:0006979|response to oxidative stress;GO:0034612|response to tumor necrosis factor;GO:0033280|response to vitamin D;GO:0019233|sensory perception of pain;","GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0043005|neuron projection;GO:0031090|organelle membrane;GO:0032991|macromolecular complex;","GO:0050473|arachidonate 15-lipoxygenase activity;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004601|peroxidase activity;GO:0004666|prostaglandin-endoperoxide synthase activity;GO:0042803|protein homodimerization activity;","K11987","PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]"]
["ENSG00000081041",572,510,484,310.079138769133,54,60,80,9.60144351683498,3.26325132229441,1.02905065007555e-115,8.30474014169754e-114,"up","yes","CXCL2","protein_coding","chr4:74097035-74099293:-","gi|966943489|ref|XP_001092240.2|",516,4e-59,"PREDICTED: uncharacterized protein LOC702067 [Macaca mulatta]","gi|148298657|ref|NM_002089.3|",1205,0,"Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA","P19875",152,5e-43,"C-X-C motif chemokine 2",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0019221|cytokine-mediated signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0031640|killing of cells of other organism;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0042127|regulation of cell proliferation;GO:0032496|response to lipopolysaccharide;GO:0002237|response to molecule of bacterial origin;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSG00000275011",10,7,6,4.46764343586216,0,0,3,9.57152839414853,3.25874931453367,0.00638730434882936,0.0177621577681979,"up","yes","AC129492.6","unprocessed_pseudogene","chr17:8063936-8072533:+","gi|955523706|ref|XP_014645284.1|",592,2e-65,"PREDICTED: LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B-like [Ceratotherium simum simum]","gi|24421745|gb|AC129492.6|",204,1e-100,"Homo sapiens chromosome 17, clone RP11-599B13, complete sequence","O35936",164,6e-43,"Arachidonate 8S-lipoxygenase",".",".",".",".","pfam00305","Lipoxygenase","Lipoxygenase.","GO:0019369|arachidonic acid metabolic process;GO:0051122|hepoxilin biosynthetic process;GO:0043651|linoleic acid metabolic process;GO:0019372|lipoxygenase pathway;GO:0045786|negative regulation of cell cycle;GO:0008285|negative regulation of cell proliferation;GO:0045926|negative regulation of growth;GO:0090197|positive regulation of chemokine secretion;GO:0045618|positive regulation of keratinocyte differentiation;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0035360|positive regulation of peroxisome proliferator activated receptor signaling pathway;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0019898|extrinsic component of membrane;GO:0005622|intracellular;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0050473|arachidonate 15-lipoxygenase activity;GO:0036403|arachidonate 8(S)-lipoxygenase activity;GO:0005509|calcium ion binding;GO:0005506|iron ion binding;GO:0016165|linoleate 13S-lipoxygenase activity;GO:0008289|lipid binding;","K08022","ALOX15B; arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-]"]
["ENSG00000153404",36,34,33,20.3851219100458,2,5,6,9.52637287891692,3.25192701941745,3.0832584286287e-09,1.90486510478509e-08,"up","yes","PLEKHG4B","protein_coding","chr5:92151-189972:+","gi|578809852|ref|XP_006714509.1|",8393,0,"PREDICTED: pleckstrin homology domain-containing family G member 4B isoform X1 [Homo sapiens]","gi|767934246|ref|XM_006714446.2|",12612,0,"PREDICTED: Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 4B (PLEKHG4B), transcript variant X1, mRNA","Q96PX9",2500,0,"Pleckstrin homology domain-containing family G member 4B",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0035023|regulation of Rho protein signal transduction;",".","GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["ENSG00000103154",69,48,64,35.9883993346092,6,9,8,9.34044697436784,3.22349158979302,1.19051999596693e-14,1.08365973016565e-13,"up","yes","NECAB2","protein_coding","chr16:83968632-84002776:+","gi|795165534|ref|XP_011797572.1|",1837,0,"PREDICTED: N-terminal EF-hand calcium-binding protein 2 isoform X1 [Colobus angolensis palliatus]","gi|16877464|gb|BC016979.1|",1602,0,"Homo sapiens EF-hand calcium binding protein 2, mRNA (cDNA clone IMAGE:4181575)","Q7Z6G3",528,0,"N-terminal EF-hand calcium-binding protein 2",".",".",".",".","pfam03992","ABM","Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.","GO:1904021|negative regulation of G-protein coupled receptor internalization;GO:0060168|positive regulation of adenosine receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1900451|positive regulation of glutamate receptor signaling pathway;","GO:0030424|axon;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0005886|plasma membrane;","GO:0031687|A2A adenosine receptor binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0031802|type 5 metabotropic glutamate receptor binding;",".","."]
["ENSG00000103522",30,45,26,20.0642818299378,2,6,5,9.31071192063762,3.21889148412195,1.21536464107053e-08,7.13171682292925e-08,"up","yes","IL21R","protein_coding","chr16:27402162-27452042:+","gi|302034748|ref|NP_851565.4|",2619,0,"interleukin-21 receptor isoform 2 precursor [Homo sapiens]","gi|301897495|ref|NM_181078.2|",4849,0,"Homo sapiens interleukin 21 receptor (IL21R), transcript variant 2, mRNA","Q9HBE5",1004,0,"Interleukin-21 receptor",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0038114|interleukin-21-mediated signaling pathway;GO:0030101|natural killer cell activation;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0001532|interleukin-21 receptor activity;","K05075","IL21R; interleukin 21 receptor"]
["ENSG00000171931",49,29,45,24.3729665271659,1,9,6,9.25249616745278,3.20984263293587,7.92856095404279e-10,5.19450012505358e-09,"up","yes","FBXW10","protein_coding","chr17:18744024-18779349:+","gi|578829637|ref|XP_006721483.1|",5624,0,"PREDICTED: F-box/WD repeat-containing protein 10 isoform X7 [Homo sapiens]","gi|767991519|ref|XM_006721420.2|",3456,0,"PREDICTED: Homo sapiens F-box and WD repeat domain containing 10 (FBXW10), transcript variant X7, mRNA","Q5XX13",2075,0,"F-box/WD repeat-containing protein 10",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;","GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;","K10266","FBXW10; F-box and WD-40 domain protein 10"]
["ENSG00000079393",9,26,42,15.8093182646893,3,6,1,9.12126947492554,3.18923462896506,7.51462398433476e-06,3.32817605992764e-05,"up","yes","DUSP13","protein_coding","chr10:75094432-75109221:-","gi|530393800|ref|XP_005269940.1|",1610,0,"PREDICTED: dual specificity protein phosphatase 13 isoform X3 [Homo sapiens]","gi|767963025|ref|XM_011539853.1|",1778,0,"PREDICTED: Homo sapiens dual specificity phosphatase 13 (DUSP13), transcript variant X1, mRNA","Q9UII6",409,6e-139,"Dual specificity protein phosphatase 13 isoform B","SPBC17A3.06",66.2,6e-11,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0016311|dephosphorylation;GO:0051321|meiotic cell cycle;GO:0006470|protein dephosphorylation;GO:0007283|spermatogenesis;",".","GO:0016791|phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;",".","."]
["ENSG00000105550",15,9,7,6.11600524345189,2,0,2,9.06240929145757,3.17989464969281,0.00159129979404598,0.00502011619685292,"up","yes","FGF21","protein_coding","chr19:48755559-48758333:+","gi|426389482|ref|XP_004061150.1|",908,5e-118,"PREDICTED: fibroblast growth factor 21 [Gorilla gorilla gorilla]","gi|530416158|ref|XM_005258731.1|",1312,0,"PREDICTED: Homo sapiens fibroblast growth factor 21 (FGF21), transcript variant X1, mRNA","Q9NSA1",354,2e-119,"Fibroblast growth factor 21",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0007267|cell-cell signaling;GO:0035690|cellular response to drug;GO:0071377|cellular response to glucagon stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0072577|endothelial cell apoptotic process;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:1901215|negative regulation of neuron death;GO:0008284|positive regulation of cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0046326|positive regulation of glucose import;GO:0045716|positive regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0010898|positive regulation of triglyceride catabolic process;GO:0010988|regulation of low-density lipoprotein particle clearance;GO:0014823|response to activity;GO:1904640|response to methionine;GO:0031667|response to nutrient levels;GO:0007165|signal transduction;","GO:0005623|cell;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;",".","."]
["ENSG00000151632",465,468,461,279.277827081991,54,59,75,8.82902107059741,3.14225348601794,5.45291143995441e-99,3.50585852846136e-97,"up","yes","AKR1C2","protein_coding","chr10:4987400-5018031:-","gi|4503285|ref|NP_001345.1|",1729,0,"aldo-keto reductase family 1 member C2 isoform 1 [Homo sapiens]","gi|359751395|ref|NM_001354.5|",3374,0,"Homo sapiens aldo-keto reductase family 1, member C2 (AKR1C2), transcript variant 1, mRNA","P52895",670,0,"Aldo-keto reductase family 1 member C2","slr0942",213,5e-60,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0071395|cellular response to jasmonic acid stimulus;GO:0071799|cellular response to prostaglandin D stimulus;GO:0044597|daunorubicin metabolic process;GO:0007586|digestion;GO:0044598|doxorubicin metabolic process;GO:0030855|epithelial cell differentiation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0055114|oxidation-reduction process;GO:0008284|positive regulation of cell proliferation;GO:0051897|positive regulation of protein kinase B signaling;GO:0042448|progesterone metabolic process;GO:0006693|prostaglandin metabolic process;GO:0008202|steroid metabolic process;","GO:0005737|cytoplasm;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0032052|bile acid binding;GO:0031406|carboxylic acid binding;GO:0047086|ketosteroid monooxygenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0047115|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;","K00089","E1.1.1.213; 3alpha-hydroxysteroid dehydrogenase (A-specific) [EC:1.1.1.213]"]
["ENSG00000104081",301,283,245,165.674619065841,40,26,45,8.82764481168253,3.14202858263825,6.2520420621977e-57,2.06135704778922e-55,"up","yes","BMF","protein_coding","chr15:40087890-40108892:-","gi|38511854|gb|AAH60783.1|",1068,2e-130,"BMF protein, partial [Homo sapiens]","gi|51558687|ref|NM_001003940.1|",4684,0,"Homo sapiens Bcl2 modifying factor (BMF), transcript variant 1, mRNA","Q96LC9",329,4e-102,"Bcl-2-modifying factor",".",".",".",".","pfam15185","BMF","Bcl-2-modifying factor, apoptosis. BMF is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.","GO:0043276|anoikis;GO:0034644|cellular response to UV;GO:0010507|negative regulation of autophagy;GO:0043065|positive regulation of apoptotic process;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;GO:0032464|positive regulation of protein homooligomerization;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0001844|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;","GO:0001669|acrosomal vesicle;GO:0005829|cytosol;GO:0005741|mitochondrial outer membrane;GO:0016459|myosin complex;GO:0005886|plasma membrane;",".","K17460","BMF; Bcl-2-modifying factor"]
["ENSG00000078018",457,365,351,233.754751280101,39,57,63,8.76892827051919,3.13240052872594,6.3095417631252e-81,3.08879293216139e-79,"up","yes","MAP2","protein_coding","chr2:209424058-209734118:+","gi|87578396|ref|NP_002365.3|",8358,0,"microtubule-associated protein 2 isoform 1 [Homo sapiens]","gi|114583027|ref|XM_001144480.1|",9528,0,"PREDICTED: Pan troglodytes microtubule-associated protein 2 (MAP2), transcript variant X9, mRNA","P11137",3224,0,"Microtubule-associated protein 2",".",".",".",".","pfam08377","MAP2_projctn","MAP2/Tau projection domain. This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.","GO:0007409|axonogenesis;GO:0071310|cellular response to organic substance;GO:0021954|central nervous system neuron development;GO:0016358|dendrite development;GO:0048813|dendrite morphogenesis;GO:0030010|establishment of cell polarity;GO:0001578|microtubule bundle formation;GO:0000226|microtubule cytoskeleton organization;GO:0030517|negative regulation of axon extension;GO:1904527|negative regulation of microtubule binding;GO:2000575|negative regulation of microtubule motor activity;GO:0031115|negative regulation of microtubule polymerization;GO:0031175|neuron projection development;GO:1901953|positive regulation of anterograde dense core granule transport;GO:1903744|positive regulation of anterograde synaptic vesicle transport;GO:1903827|regulation of cellular protein localization;GO:0031113|regulation of microtubule polymerization;GO:1902513|regulation of organelle transport along microtubule;","GO:0043203|axon hillock;GO:0043194|axon initial segment;GO:0097441|basilar dendrite;GO:0097442|CA3 pyramidal cell dendrite;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0044307|dendritic branch;GO:1902737|dendritic filopodium;GO:0044294|dendritic growth cone;GO:0043198|dendritic shaft;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0034399|nuclear periphery;GO:0005730|nucleolus;GO:0014069|postsynaptic density;GO:1990635|proximal dendrite;GO:1990769|proximal neuron projection;","GO:0005516|calmodulin binding;GO:0002162|dystroglycan binding;GO:0008017|microtubule binding;GO:0005198|structural molecule activity;","K10430","MAP2; microtubule-associated protein 2"]
["ENSG00000175868",8,9,11,5.62272638716551,0,2,2,8.57335056299924,3.0998591361861,0.00246503633029973,0.00748882268959028,"up","yes","CALCB","protein_coding","chr11:14904997-15082342:+","gi|9945304|ref|NP_000719.1|",657,3e-78,"calcitonin gene-related peptide 2 precursor [Homo sapiens]","gi|16549331|dbj|AK054728.1|",2255,0,"Homo sapiens cDNA FLJ30166 fis, clone BRACE2000718, highly similar to CALCITONIN GENE-RELATED PEPTIDE II PRECURSOR","P10092",257,1e-79,"Calcitonin gene-related peptide 2",".",".",".",".","pfam00214","Calc_CGRP_IAPP","Calcitonin / CGRP / IAPP family.","GO:0006874|cellular calcium ion homeostasis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007165|signal transduction;","GO:0005623|cell;GO:0005576|extracellular region;","GO:0005184|neuropeptide hormone activity;",".","."]
["ENSG00000125538",3339,3247,2965,1916.72570069687,351,435,560,8.46054799727352,3.0807511110219,0,0,"up","yes","IL1B","protein_coding","chr2:112829751-112836903:-","gi|119594013|gb|EAW73607.1|",1394,0,"interleukin 1, beta, isoform CRA_c [Homo sapiens]","gi|675675817|ref|XM_003804503.2|",1602,0,"PREDICTED: Pan paniscus interleukin 1, beta (IL1B), mRNA","P01584",529,0,"Interleukin-1 beta",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0000187|activation of MAPK activity;GO:0006915|apoptotic process;GO:0007267|cell-cell signaling;GO:0035690|cellular response to drug;GO:0071260|cellular response to mechanical stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071310|cellular response to organic substance;GO:0019221|cytokine-mediated signaling pathway;GO:0035234|ectopic germ cell programmed cell death;GO:0007566|embryo implantation;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0001660|fever generation;GO:0030213|hyaluronan biosynthetic process;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0032611|interleukin-1 beta production;GO:0070498|interleukin-1-mediated signaling pathway;GO:0032635|interleukin-6 production;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0000165|MAPK cascade;GO:0070487|monocyte aggregation;GO:0070164|negative regulation of adiponectin secretion;GO:0008285|negative regulation of cell proliferation;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0010829|negative regulation of glucose transport;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0050995|negative regulation of lipid catabolic process;GO:0045833|negative regulation of lipid metabolic process;GO:0043407|negative regulation of MAP kinase activity;GO:0050805|negative regulation of synaptic transmission;GO:0030593|neutrophil chemotaxis;GO:0045766|positive regulation of angiogenesis;GO:0060559|positive regulation of calcidiol 1-monooxygenase activity;GO:0060355|positive regulation of cell adhesion molecule production;GO:0051781|positive regulation of cell division;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0045080|positive regulation of chemokine biosynthetic process;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0031622|positive regulation of fever generation;GO:0010628|positive regulation of gene expression;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0035066|positive regulation of histone acetylation;GO:0033129|positive regulation of histone phosphorylation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032729|positive regulation of interferon-gamma production;GO:0045086|positive regulation of interleukin-2 biosynthetic process;GO:0045410|positive regulation of interleukin-6 biosynthetic process;GO:0032755|positive regulation of interleukin-6 production;GO:2000778|positive regulation of interleukin-6 secretion;GO:0032757|positive regulation of interleukin-8 production;GO:0046330|positive regulation of JNK cascade;GO:0050996|positive regulation of lipid catabolic process;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0045840|positive regulation of mitotic nuclear division;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0035505|positive regulation of myosin light chain kinase activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:1900745|positive regulation of p38MAPK cascade;GO:0050766|positive regulation of phagocytosis;GO:0032308|positive regulation of prostaglandin secretion;GO:0046827|positive regulation of protein export from nucleus;GO:0001934|positive regulation of protein phosphorylation;GO:0002711|positive regulation of T cell mediated immunity;GO:0042102|positive regulation of T cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0043491|protein kinase B signaling;GO:0050691|regulation of defense response to virus by host;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:1903140|regulation of establishment of endothelial barrier;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050796|regulation of insulin secretion;GO:0050999|regulation of nitric-oxide synthase activity;GO:0033198|response to ATP;GO:0009743|response to carbohydrate;GO:0030730|sequestering of triglyceride;GO:0007165|signal transduction;GO:0014805|smooth muscle adaptation;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0030141|secretory granule;","GO:0005125|cytokine activity;GO:0005178|integrin binding;GO:0005149|interleukin-1 receptor binding;GO:0019904|protein domain specific binding;","K04519","IL1B; interleukin 1 beta"]
["ENSG00000138100",20,20,16,11.1790991183538,1,3,4,8.44380743380019,3.07789367751627,1.88924748212285e-05,7.97719033169562e-05,"up","yes","TRIM54","protein_coding","chr2:27282392-27307439:+","gi|78482627|ref|NP_115935.3|",1738,0,"tripartite motif-containing protein 54 isoform 1 [Homo sapiens]","gi|301897806|ref|NM_032546.3|",2027,0,"Homo sapiens tripartite motif containing 54 (TRIM54), transcript variant 1, mRNA","Q9BYV2",594,0,"Tripartite motif-containing protein 54",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0007017|microtubule-based process;GO:0007275|multicellular organismal development;GO:0055001|muscle cell development;GO:0007026|negative regulation of microtubule depolymerization;GO:0007165|signal transduction;","GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0030018|Z disc;","GO:0008017|microtubule binding;GO:0008270|zinc ion binding;","K10653","TRIM54, MURF3; tripartite motif-containing protein 54"]
["ENSG00000182557",30,24,31,17.1652881080864,5,2,5,8.37942759810755,3.06685169624248,1.79206819359209e-07,9.39277481467508e-07,"up","yes","SPNS3","protein_coding","chr17:4433688-4488208:+","gi|194239645|ref|NP_872344.3|",2398,0,"protein spinster homolog 3 isoform 1 [Homo sapiens]","gi|194239644|ref|NM_182538.4|",1893,0,"Homo sapiens spinster homolog 3 (Drosophila) (SPNS3), transcript variant 1, mRNA","Q6ZMD2",926,0,"Protein spinster homolog 3","CC0336",71.2,4e-12,"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0040011|locomotion;GO:0003376|sphingosine-1-phosphate signaling pathway;GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;GO:0005765|lysosomal membrane;GO:0031982|vesicle;","GO:0046624|sphingolipid transporter activity;",".","."]
["ENSG00000134548",232,168,177,115.479849808737,16,38,28,8.35734209005005,3.06304419072764,1.04294739059139e-37,2.27047057220393e-36,"up","yes","SPX","protein_coding","chr12:21526307-21541249:+","gi|635063992|ref|XP_007966065.1|",362,5e-36,"PREDICTED: spexin [Chlorocebus sabaeus]","gi|270309111|ref|NG_016167.1|",4207,0,"Homo sapiens glycogen synthase 2 (GYS2), RefSeqGene on chromosome 12","Q9BT56",133,6e-34,"Spexin","YLR258w",62,1e-08,"COG0438","pfam15171","Spexin","Neuropeptide secretory protein family, NPQ, spexin. Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors. Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance.","GO:0044539|long-chain fatty acid import;GO:0032099|negative regulation of appetite;GO:0010459|negative regulation of heart rate;GO:0035814|negative regulation of renal sodium excretion;GO:1904306|positive regulation of gastro-intestinal system smooth muscle contraction;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051930|regulation of sensory perception of pain;","GO:0031045|dense core granule;GO:0005615|extracellular space;GO:0030133|transport vesicle;","GO:0005184|neuropeptide hormone activity;GO:0031765|type 2 galanin receptor binding;GO:0031766|type 3 galanin receptor binding;",".","."]
["ENSG00000198796",5,8,8,4.27736829280355,1,1,1,8.33569902558556,3.05930318762913,0.00834287289014724,0.0225785509057331,"up","yes","ALPK2","protein_coding","chr18:58481247-58628957:-","gi|148596992|ref|NP_443179.3|",11169,0,"alpha-protein kinase 2 [Homo sapiens]","gi|148596991|ref|NM_052947.3|",7303,0,"Homo sapiens alpha kinase 2 (ALPK2), mRNA","Q86TB3",4303,0,"Alpha-protein kinase 2",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.",".","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08868","ALPK; alpha-kinase"]
["ENSG00000161011",53824,53317,50446,31738.9716420205,5938,7306,9541,8.27250870218725,3.04832490416801,0,0,"up","yes","SQSTM1","protein_coding","chr5:179806398-179838078:+","gi|4505571|ref|NP_003891.1|",1965,0,"sequestosome-1 isoform 1 [Homo sapiens]","gi|188497651|ref|NM_003900.4|",2903,0,"Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA","Q13501",761,0,"Sequestosome-1",".",".",".",".","pfam00564","PB1","PB1 domain.","GO:0035973|aggrephagy;GO:0006915|apoptotic process;GO:0006914|autophagy;GO:0000422|mitophagy;GO:0030154|cell differentiation;GO:0016197|endosomal transport;GO:0007032|endosome organization;GO:0002376|immune system process;GO:0070498|interleukin-1-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0016236|macroautophagy;GO:0000423|macromitophagy;GO:0043066|negative regulation of apoptotic process;GO:0044130|negative regulation of growth of symbiont in host;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0043065|positive regulation of apoptotic process;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1903078|positive regulation of protein localization to plasma membrane;GO:0001934|positive regulation of protein phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051291|protein heterooligomerization;GO:0008104|protein localization;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0010821|regulation of mitochondrion organization;GO:0061635|regulation of protein complex stability;GO:0046578|regulation of Ras protein signal transduction;GO:0002931|response to ischemia;GO:0098780|response to mitochondrial depolarisation;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0016235|aggresome;GO:0044753|amphisome;GO:0044754|autolysosome;GO:0005776|autophagosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0070062|extracellular exosome;GO:0016234|inclusion body;GO:0043231|intracellular membrane-bounded organelle;GO:0005770|late endosome;GO:0097413|Lewy body;GO:0005654|nucleoplasm;GO:0000932|cytoplasmic mRNA processing body;GO:0000407|pre-autophagosomal structure;GO:0016605|PML body;GO:0030017|sarcomere;GO:0097225|sperm midpiece;","GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0035255|ionotropic glutamate receptor binding;GO:0070530|K63-linked polyubiquitin binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0005080|protein kinase C binding;GO:0004674|protein serine/threonine kinase activity;GO:0030971|receptor tyrosine kinase binding;GO:0042169|SH2 domain binding;GO:0043130|ubiquitin binding;GO:0031625|ubiquitin protein ligase binding;GO:0008270|zinc ion binding;","K14381","SQSTM1; sequestosome 1"]
["ENSG00000168702",192,174,179,110.101510678787,24,34,20,8.21413700938365,3.03810901124561,7.18343601403107e-37,1.53098468329979e-35,"up","yes","LRP1B","protein_coding","chr2:140231423-142131701:-","gi|694896575|ref|XP_009441673.1|",23209,0,"PREDICTED: low-density lipoprotein receptor-related protein 1B [Pan troglodytes]","gi|93102378|ref|NM_018557.2|",16531,0,"Homo sapiens LDL receptor related protein 1B (LRP1B), mRNA","Q9NZR2",8937,0,"Low-density lipoprotein receptor-related protein 1B",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0015031|protein transport;GO:0006898|receptor-mediated endocytosis;","GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0005509|calcium ion binding;",".","."]
["ENSG00000128965",1322,1281,1232,773.074018784971,144,174,244,8.1538253612801,3.02747705749935,2.83760084266989e-249,7.20153224387063e-247,"up","yes","CHAC1","protein_coding","chr15:40952962-40956519:+","gi|958753309|ref|XP_014712856.1|",1260,2e-166,"PREDICTED: LOW QUALITY PROTEIN: glutathione-specific gamma-glutamylcyclotransferase 1 [Equus asinus]","gi|426378710|ref|XM_004056008.1|",1798,0,"PREDICTED: Gorilla gorilla gorilla ChaC, cation transport regulator homolog 1 (E. coli) (CHAC1), mRNA","Q9BUX1",422,2e-143,"Glutathione-specific gamma-glutamylcyclotransferase 1","SPBC31F10.03",100,4e-23,"COG3703","pfam04752","ChaC","ChaC-like protein. The ChaC protein is thought to be associated with the putative ChaA Ca2+/H+ cation transport protein in Escherichia coli. Its function is not known. This family also includes homologues regions from several other bacterial and eukaryotic proteins.","GO:0006750|glutathione biosynthetic process;GO:0006751|glutathione catabolic process;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0045746|negative regulation of Notch signaling pathway;GO:0010955|negative regulation of protein processing;GO:0022008|neurogenesis;GO:0007219|Notch signaling pathway;GO:0006986|response to unfolded protein;","GO:0005829|cytosol;GO:0005802|trans-Golgi network;","GO:0003839|gamma-glutamylcyclotransferase activity;GO:0005112|Notch binding;","K07232","chaC; cation transport protein ChaC"]
["ENSG00000138135",4,11,6,4.30829046464732,2,0,1,8.14789194986289,3.02642684868493,0.0107358416631582,0.0283506180173871,"up","yes","CH25H","protein_coding","chr10:89205629-89207314:-","gi|4502499|ref|NP_003947.1|",1275,1e-170,"cholesterol 25-hydroxylase [Homo sapiens]","gi|21213137|emb|AL513533.15|",1686,0,"Human DNA sequence from clone RP11-341B24 on chromosome 10, complete sequence","O95992",495,4e-172,"Cholesterol 25-hydroxylase","YGR060w",86.3,1e-17,"COG3000","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.","GO:0035754|B cell chemotaxis;GO:0006699|bile acid biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0006629|lipid metabolic process;GO:0016126|sterol biosynthetic process;","GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0001567|cholesterol 25-hydroxylase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;","K10223","CH25H; cholesterol 25-hydroxylase [EC:1.14.99.38]"]
["ENSG00000100292",2248,2120,1994,1284.66331371654,272,310,355,8.05463313782715,3.00981888039174,0,0,"up","yes","HMOX1","protein_coding","chr22:35380361-35394214:+","gi|4504437|ref|NP_002124.1|",1525,0,"heme oxygenase 1 [Homo sapiens]","gi|410055845|ref|XM_525579.4|",1738,0,"PREDICTED: Pan troglodytes heme oxygenase (decycling) 1 (HMOX1), mRNA","P09601",592,0,"Heme oxygenase 1","sll1184",206,2e-60,"COG5398","pfam01126","Heme_oxygenase","Heme oxygenase.","GO:0001525|angiogenesis;GO:0008219|cell death;GO:0006879|cellular iron ion homeostasis;GO:0071243|cellular response to arsenic-containing substance;GO:0071276|cellular response to cadmium ion;GO:0072719|cellular response to cisplatin;GO:0034605|cellular response to heat;GO:0071456|cellular response to hypoxia;GO:0031670|cellular response to nutrient;GO:0019221|cytokine-mediated signaling pathway;GO:0001935|endothelial cell proliferation;GO:0034101|erythrocyte homeostasis;GO:0007588|excretion;GO:0042167|heme catabolic process;GO:0006788|heme oxidation;GO:0035556|intracellular signal transduction;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0055072|iron ion homeostasis;GO:0097421|liver regeneration;GO:0034383|low-density lipoprotein particle clearance;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0002686|negative regulation of leukocyte migration;GO:0016242|negative regulation of macroautophagy;GO:0032764|negative regulation of mast cell cytokine production;GO:0043305|negative regulation of mast cell degranulation;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:0045766|positive regulation of angiogenesis;GO:0043065|positive regulation of apoptotic process;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0045080|positive regulation of chemokine biosynthetic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016239|positive regulation of macroautophagy;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051260|protein homooligomerization;GO:0045765|regulation of angiogenesis;GO:0008217|regulation of blood pressure;GO:0051090|regulation of sequence-specific DNA binding transcription factor activity;GO:0034395|regulation of transcription from RNA polymerase II promoter in response to iron;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043627|response to estrogen;GO:0042542|response to hydrogen peroxide;GO:0035094|response to nicotine;GO:0006979|response to oxidative stress;GO:0007264|small GTPase mediated signal transduction;GO:0014806|smooth muscle hyperplasia;GO:0002246|wound healing involved in inflammatory response;","GO:0005901|caveola;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005615|extracellular space;GO:0016020|membrane;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0004392|heme oxygenase (decyclizing) activity;GO:0046872|metal ion binding;GO:0004630|phospholipase D activity;GO:0042803|protein homodimerization activity;","K00510","HMOX, hmuO, ho; heme oxygenase [EC:1.14.99.3]"]
["ENSG00000116701",85,103,89,56.3675951070358,13,19,9,7.93093905360977,2.98749169667048,3.23105432596657e-19,3.73177100833792e-18,"up","yes","NCF2","protein_coding","chr1:183555563-183590876:-","gi|299829294|ref|NP_001177723.1|",2382,0,"neutrophil cytosol factor 2 isoform 2 [Homo sapiens]","gi|299829293|ref|NM_001190794.1|",2276,0,"Homo sapiens neutrophil cytosolic factor 2 (NCF2), transcript variant 3, mRNA","P19878",900,0,"Neutrophil cytosol factor 2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006968|cellular defense response;GO:0045087|innate immune response;GO:0006909|phagocytosis;GO:0045730|respiratory burst;GO:0042554|superoxide anion generation;GO:0006801|superoxide metabolic process;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0001669|acrosomal vesicle;GO:0005829|cytosol;GO:0043020|NADPH oxidase complex;GO:0005730|nucleolus;GO:0032010|phagolysosome;","GO:0009055|electron carrier activity;GO:0008022|protein C-terminus binding;GO:0048365|Rac GTPase binding;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0016175|superoxide-generating NADPH oxidase activity;","K08010","NCF2, P67PHOX; neutrophil cytosolic factor 2"]
["ENSG00000260784",4,11,5,4.0823771597582,1,1,1,7.91329252462045,2.9842780892118,0.01206890399201,0.0315397372071566,"up","yes","AC026150.2","unprocessed_pseudogene","chr15:30516079-30517867:+","gi|767986031|ref|XP_011520586.1|",341,5e-60,"PREDICTED: golgin subfamily A member 6-like protein 1 isoform X2 [Homo sapiens]","gi|595077258|gb|AC254991.1|",931,0,"Homo sapiens chromosome 15 clone VMRC54-479I6, complete sequence",".",".",".",".",".",".",".",".","pfam15070","GOLGA2L5","Putative golgin subfamily A member 2-like protein 5. The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.",".",".",".",".","."]
["ENSG00000251556",6,9,11,5.32133242729201,1,1,2,7.87506555422947,2.97729193294349,0.00388853269289383,0.0113193508271259,"up","yes","AC091887.1","antisense","chr5:146099406-146120412:+",".",".",".",".","gi|551857634|tpe|HG498578.1|",439,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000373456.1 (RP11-118M9.3 gene), antisense",".",".",".",".",".",".",".",".","pfam03083","MtN3_slv","Sugar efflux transporter for intercellular exchange. This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.",".",".",".",".","."]
["ENSG00000164220",389,332,349,216.85601688154,43,50,73,7.6962505863038,2.94415577334552,9.14472089943239e-73,3.93712894438062e-71,"up","yes","F2RL2","protein_coding","chr5:76615482-76623434:-","gi|4758326|ref|NP_004092.1|",1894,0,"proteinase-activated receptor 3 isoform 1 precursor [Homo sapiens]","gi|375151566|ref|NM_004101.3|",3429,0,"Homo sapiens coagulation factor II thrombin receptor like 2 (F2RL2), transcript variant 1, mRNA","O00254",734,0,"Proteinase-activated receptor 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007596|blood coagulation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0030168|platelet activation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0035025|positive regulation of Rho protein signal transduction;GO:0009611|response to wounding;","GO:0016324|apical plasma membrane;GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0004930|G-protein coupled receptor activity;GO:0004435|phosphatidylinositol phospholipase C activity;GO:0015057|thrombin receptor activity;","K04235","F2RL2, PAR3; coagulation factor II (thrombin) receptor-like 2"]
["ENSG00000109511",25,23,36,17.2629637748987,4,6,3,7.63439809687276,2.93251441807162,5.07785740423636e-07,2.55288984559768e-06,"up","yes","ANXA10","protein_coding","chr4:168092515-168187690:+","gi|48762937|ref|NP_009124.2|",1759,0,"annexin A10 [Homo sapiens]","gi|319655771|ref|NM_007193.4|",1395,0,"Homo sapiens annexin A10 (ANXA10), mRNA","Q9UJ72",682,0,"Annexin A10",".",".",".",".","pfam00191","Annexin","Annexin. This family of annexins also includes giardin that has been shown to function as an annexin.",".",".","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;","K17097","ANXA10; annexin A10"]
["ENSG00000230601",5,16,5,5.37345829655635,2,2,0,7.41369116422452,2.89019201735265,0.00701212468573283,0.0193186488985023,"up","yes","TEX48","protein_coding","chr9:114666434-114682066:-","gi|312839862|ref|NP_001186162.1|",572,1e-71,"uncharacterized protein LOC100505478 [Homo sapiens]","gi|312839861|ref|NM_001199233.1|",708,0,"Homo sapiens uncharacterized LOC100505478 (LOC100505478), transcript variant 1, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSG00000168209",4357,4453,4054,2625.40173395938,557,645,888,7.35056199390267,2.87785455672736,0,0,"up","yes","DDIT4","protein_coding","chr10:72273920-72276036:+","gi|9506687|ref|NP_061931.1|",946,2e-121,"DNA damage-inducible transcript 4 protein [Homo sapiens]","gi|56676369|ref|NM_019058.2|",1748,0,"Homo sapiens DNA damage inducible transcript 4 (DDIT4), mRNA","Q9NX09",369,8e-123,"DNA damage-inducible transcript 4 protein",".",".",".",".","pfam07809","RTP801_C","RTP801 C-terminal region. The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2 ) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.","GO:0007420|brain development;GO:0008283|cell proliferation;GO:0071549|cellular response to dexamethasone stimulus;GO:0051607|defense response to virus;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045820|negative regulation of glycolytic process;GO:1902532|negative regulation of intracellular signal transduction;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0010801|negative regulation of peptidyl-threonine phosphorylation;GO:0032007|negative regulation of TOR signaling;GO:0030182|neuron differentiation;GO:0001764|neuron migration;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:1901216|positive regulation of neuron death;GO:0032984|macromolecular complex disassembly;GO:0072593|reactive oxygen species metabolic process;GO:0001666|response to hypoxia;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005622|intracellular;GO:0005739|mitochondrion;","GO:0071889|14-3-3 protein binding;","K08270","DDIT4, REDD1; DNA-damage-inducible transcript 4"]
["ENSG00000271662",11,6,8,5.08768206617812,2,0,2,7.34373184400884,2.87651337977817,0.00612603163082352,0.0171071229325791,"up","yes","AC233280.2","processed_pseudogene","chr3:195650146-195651472:-","gi|795596549|ref|XP_011915263.1|",554,2e-109,"PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X3 [Cercocebus atys]","gi|694905899|ref|XR_679434.1|",965,0,"PREDICTED: Pan troglodytes serine/threonine-protein phosphatase 4 regulatory subunit 2-like (LOC744213), misc_RNA","Q9NY27",216,2e-110,"Serine/threonine-protein phosphatase 4 regulatory subunit 2",".",".",".",".","pfam09184","PPP4R2","PPP4R2. PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.","GO:0006464|cellular protein modification process;GO:0006397|mRNA processing;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0008380|RNA splicing;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0030289|protein phosphatase 4 complex;","GO:0030674|protein binding, bridging;GO:0019888|protein phosphatase regulator activity;","K15425","PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2"]
["ENSG00000197632",52,40,54,29.8887958168793,5,11,8,7.24919518629563,2.85782083441156,4.78128444085805e-11,3.4617648008735e-10,"up","yes","SERPINB2","protein_coding","chr18:63871692-63903890:+","gi|4505595|ref|NP_002566.1|",2103,0,"plasminogen activator inhibitor 2 [Homo sapiens]","gi|219689109|ref|NM_001143818.1|",2155,0,"Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2), transcript variant 1, mRNA","P05120",814,0,"Plasminogen activator inhibitor 2","MA2246",220,8e-63,"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0042730|fibrinolysis;GO:0035722|interleukin-12-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0042060|wound healing;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSG00000244242",78,58,60,40.2107868961919,18,5,8,7.2243932647251,2.852876429035,2.20563365424315e-12,1.74139426619083e-11,"up","yes","IFITM10","protein_coding","chr11:1732410-1750591:-","gi|675736237|ref|XP_008967359.1|",918,4e-111,"PREDICTED: interferon-induced transmembrane protein 10 [Pan paniscus]","gi|334848152|ref|NM_001170820.3|",3475,0,"Homo sapiens interferon induced transmembrane protein 10 (IFITM10), mRNA","A6NMD0",358,1e-112,"Interferon-induced transmembrane protein 10",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0009607|response to biotic stimulus;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K06566","IFITM; interferon induced transmembrane protein"]
["ENSG00000283511",103,79,104,58.3508173506807,9,13,26,7.22180474952949,2.85235941575964,3.19349943329819e-19,3.6906061755216e-18,"up","yes","AC137936.2","transcribed_unitary_pseudogene","chr3:58180009-58187495:+","gi|829889211|ref|XP_012644786.1|",159,1e-09,"PREDICTED: uncharacterized protein LOC105884915 [Microcebus murinus]","gi|28014555|gb|AC137936.3|",754,0,"Homo sapiens chromosome 3 clone RP11-456N14, complete sequence",".",".",".",".",".",".",".",".","pfam06636","DUF1157","Protein of unknown function (DUF1157). This family consists of several uncharacterized proteins from Melanoplus sanguinipes entomopoxvirus (MsEPV). The function of this family is unknown.",".",".",".",".","."]
["ENSG00000233355",19,14,19,10.5613974238615,1,1,7,7.16560512773839,2.84108854369519,0.00011618326126599,0.000439314397823646,"up","yes","CHRM3-AS2","antisense","chr1:239703381-239730465:-","gi|119590485|gb|EAW70079.1|",684,1e-81,"hCG2038857, partial [Homo sapiens]","gi|685843745|tpe|LN607897.1|",2431,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000095642.3 (RP11-343J24.1 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000274317",7,7,10,5.0019716853212,2,1,1,7.01149065162578,2.80972119560346,0.00686194981618525,0.0189400812900087,"up","yes","LINC02334","lincRNA","chr13:37934565-38048169:+","gi|2072963|gb|AAC51270.1|",543,2e-57,"p40 [Homo sapiens]","gi|666670179|tpe|LK938484.1|",4959,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000474785.1 (RP11-93G5.1 gene), lincRNA","Q9UN81",209,1e-57,"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.","GO:0032197|transposition, RNA-mediated;","GO:0005737|cytoplasm;GO:0010494|cytoplasmic stress granule;GO:0005730|nucleolus;","GO:0042802|identical protein binding;GO:0000166|nucleotide binding;GO:0003697|single-stranded DNA binding;GO:0003727|single-stranded RNA binding;",".","."]
["ENSG00000107731",591,574,533,348.927347254325,65,108,123,6.86153215563666,2.77853076102339,2.35327180670155e-105,1.64456183361085e-103,"up","yes","UNC5B","protein_coding","chr10:71212570-71302864:+","gi|32261318|ref|NP_734465.2|",4699,0,"netrin receptor UNC5B isoform 1 precursor [Homo sapiens]","gi|349585201|ref|NM_170744.4|",6841,0,"Homo sapiens unc-5 netrin receptor B (UNC5B), transcript variant 1, mRNA","Q8IZJ1",1810,0,"Netrin receptor UNC5B",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0001525|angiogenesis;GO:0033564|anterior/posterior axon guidance;GO:0006915|apoptotic process;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0043524|negative regulation of neuron apoptotic process;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;","GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0005042|netrin receptor activity;","K07521","UNC5; netrin receptor unc-5"]
["ENSG00000198074",80,90,76,50.792322920068,13,9,22,6.69914450262703,2.74397687159717,8.67257746416694e-17,8.82726512553309e-16,"up","yes","AKR1B10","protein_coding","chr7:134527592-134541408:+","gi|635116388|ref|XP_007981173.1|",1828,0,"PREDICTED: aldo-keto reductase family 1 member B10-like isoform X2 [Chlorocebus sabaeus]","gi|223468662|ref|NM_020299.4|",1590,0,"Homo sapiens aldo-keto reductase family 1, member B10 (aldose reductase) (AKR1B10), mRNA","O60218",658,0,"Aldo-keto reductase family 1 member B10","slr0942",226,1e-67,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0016488|farnesol catabolic process;GO:0001523|retinoid metabolic process;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0005764|lysosome;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0045550|geranylgeranyl reductase activity;GO:0047718|indanol dehydrogenase activity;GO:0001758|retinal dehydrogenase activity;","K00011","E1.1.1.21, AKR1; aldehyde reductase [EC:1.1.1.21]"]
["ENSG00000137752",8,6,14,5.86567949996612,1,3,1,6.66744395279097,2.73713379238657,0.00473878475313832,0.0135651054197881,"up","yes","CASP1","protein_coding","chr11:105025443-105035250:-","gi|15431328|ref|NP_150634.1|",2186,0,"caspase-1 isoform alpha precursor [Homo sapiens]","gi|574957101|ref|NM_001257118.2|",2001,0,"Homo sapiens caspase 1 (CASP1), transcript variant 6, mRNA","P29466",846,0,"Caspase-1",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0006915|apoptotic process;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0019221|cytokine-mediated signaling pathway;GO:0032611|interleukin-1 beta production;GO:0060081|membrane hyperpolarization;GO:0051882|mitochondrial depolarization;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050717|positive regulation of interleukin-1 alpha secretion;GO:0050718|positive regulation of interleukin-1 beta secretion;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0097300|programmed necrotic cell death;GO:0016540|protein autoprocessing;GO:0006508|proteolysis;GO:0070269|pyroptosis;GO:0042981|regulation of apoptotic process;GO:0010506|regulation of autophagy;GO:0050727|regulation of inflammatory response;GO:0033198|response to ATP;GO:0001666|response to hypoxia;GO:0007165|signal transduction;GO:1901998|toxin transport;","GO:0097169|AIM2 inflammasome complex;GO:0005829|cytosol;GO:0005576|extracellular region;GO:0072557|IPAF inflammasome complex;GO:0005739|mitochondrion;GO:0072558|NLRP1 inflammasome complex;GO:0072559|NLRP3 inflammasome complex;GO:0097179|protease inhibitor complex;GO:0032991|macromolecular complex;","GO:0050700|CARD domain binding;GO:0008656|cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0004197|cysteine-type endopeptidase activity;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;GO:0004175|endopeptidase activity;GO:0042802|identical protein binding;GO:0019900|kinase binding;","K01370","CASP1; caspase 1 [EC:3.4.22.36]"]
["ENSG00000172738",13,13,9,7.28819086879826,4,1,1,6.61594120095749,2.72594641264341,0.00172167670682254,0.00539261128957344,"up","yes","TMEM217","protein_coding","chr6:37212180-37258155:-","gi|31543076|ref|NP_660359.2|",1216,5e-163,"transmembrane protein 217 isoform 1 [Homo sapiens]","gi|244792861|ref|NM_145316.3|",1546,0,"Homo sapiens transmembrane protein 217 (TMEM217), transcript variant 1, mRNA","Q8N7C4",473,2e-164,"Transmembrane protein 217",".",".",".",".","pfam15049","DUF4534","Protein of unknown function (DUF4534). This family of proteins is functionally uncharacterized. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.",".","GO:0001650|fibrillar center;GO:0016021|integral component of membrane;GO:0005730|nucleolus;",".",".","."]
["ENSG00000105538",53,42,41,27.8829755638847,2,11,12,6.59179413645057,2.72067118746053,1.00975462448985e-09,6.54220597821974e-09,"up","yes","RASIP1","protein_coding","chr19:48720587-48740721:-","gi|544512536|ref|XP_005589856.1|",3803,0,"PREDICTED: ras-interacting protein 1 [Macaca fascicularis]","gi|38570104|ref|NM_017805.2|",3300,0,"Homo sapiens Ras interacting protein 1 (RASIP1), mRNA","Q5U651",1416,0,"Ras-interacting protein 1",".",".",".",".","pfam01843","DIL","DIL domain. The DIL domain has no known function.","GO:0001525|angiogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0010507|negative regulation of autophagy;GO:0043087|regulation of GTPase activity;GO:0007165|signal transduction;GO:0001570|vasculogenesis;","GO:0005795|Golgi stack;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["ENSG00000207864",3,10,9,4.63681482969327,0,4,0,6.57410937554557,2.71679545919348,0.0183916076723236,0.0457017944838672,"up","yes","MIR27B","miRNA","chr9:95085445-95085541:+",".",".",".",".","gi|795480608|ref|XM_011771316.1|",97,2e-42,"PREDICTED: Macaca nemestrina chromosome unknown open reading frame, human C9orf3 (LOC105498940), transcript variant X8, mRNA",".",".",".",".",".",".",".",".","pfam05840","Phage_GPA","Bacteriophage replication gene A protein (GPA). This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases.",".",".",".",".","."]
["ENSG00000153233",37,23,29,18.1788032161072,1,3,13,6.52856123081995,2.70676508459453,2.45339287400876e-06,1.14689873373439e-05,"up","yes","PTPRR","protein_coding","chr12:70638073-70920843:-","gi|333108251|ref|NP_002840.2|",3447,0,"receptor-type tyrosine-protein phosphatase R isoform 1 precursor [Homo sapiens]","gi|333108250|ref|NM_002849.3|",3490,0,"Homo sapiens protein tyrosine phosphatase, receptor type R (PTPRR), transcript variant 1, mRNA","Q15256",1332,0,"Receptor-type tyrosine-protein phosphatase R","SPAC11E3.09",124,2e-29,"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0038128|ERBB2 signaling pathway;GO:0001701|in utero embryonic development;GO:0010633|negative regulation of epithelial cell migration;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0006470|protein dephosphorylation;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0019901|protein kinase binding;GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;","K04458","PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]"]
["ENSG00000249328",25,20,20,13.4564708214426,2,7,3,6.41024232635499,2.6803788960675,2.03341311446839e-05,8.55035364113064e-05,"up","yes","AC036214.1","lincRNA","chr8:79769372-79871759:-","gi|355745152|gb|EHH49777.1|",206,3e-27,"hypothetical protein EGM_00492, partial [Macaca fascicularis]","gi|594191233|ref|NR_110954.1|",2126,0,"Homo sapiens uncharacterized LOC101927040 (LOC101927040), long non-coding RNA","Q6B4Z3",61.6,2e-18,"Histone demethylase UTY",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0010468|regulation of gene expression;","GO:0005634|nucleus;","GO:0051213|dioxygenase activity;GO:0071558|histone demethylase activity (H3-K27 specific);GO:0046872|metal ion binding;","K11447","UTX, UTY; histone demethylase [EC:1.14.11.-]"]
["ENSG00000149968",18,24,21,13.0977912999543,1,6,5,6.36913330112292,2.67109706679197,2.80876391756923e-05,0.000115808974865488,"up","yes","MMP3","protein_coding","chr11:102835801-102843803:-","gi|4505217|ref|NP_002413.1|",2369,0,"stromelysin-1 preproprotein [Homo sapiens]","gi|694946751|ref|XM_508723.3|",1953,0,"PREDICTED: Pan troglodytes matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3), mRNA","P08254",920,0,"Stromelysin-1",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0071732|cellular response to nitric oxide;GO:0030574|collagen catabolic process;GO:0019221|cytokine-mediated signaling pathway;GO:0022617|extracellular matrix disassembly;GO:0010727|negative regulation of hydrogen peroxide metabolic process;GO:1903209|positive regulation of oxidative stress-induced cell death;GO:0032461|positive regulation of protein oligomerization;GO:0006508|proteolysis;","GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008270|zinc ion binding;","K01394","MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]"]
["ENSG00000260729",11,9,6,5.30368453875199,0,2,3,6.3656863823059,2.67031608159882,0.00716787837782889,0.0197027273979712,"up","yes","AC009690.1","protein_coding","chr15:72284727-72375981:-","gi|332236064|ref|XP_003267225.1|",970,0,"PREDICTED: CUGBP Elav-like family member 6 isoform X3 [Nomascus leucogenys]","gi|62088447|dbj|AB209434.1|",4368,0,"Homo sapiens mRNA for BRUNO-like 6 RNA-binding protein variant protein","Q08E07",248,3e-132,"CUGBP Elav-like family member 3",".",".",".",".","pfam14845","Glycohydro_20b2","beta-acetyl hexosaminidase like.","GO:0030317|sperm motility;GO:0006397|mRNA processing;GO:0098781|ncRNA transcription;GO:0030575|nuclear body organization;GO:0048026|positive regulation of mRNA splicing, via spliceosome;GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0008380|RNA splicing;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0097322|7SK snRNA binding;","K13207","CUGBP, BRUNOL, CELF; CUG-BP- and ETR3-like factor"]
["ENSG00000127533",22,12,14,9.86818807969862,1,5,3,6.3488478916397,2.66649481364528,0.000286814042548988,0.00102597723529022,"up","yes","F2RL3","protein_coding","chr19:16888860-16892606:+","gi|635036847|ref|XP_007993857.1|",1455,0,"PREDICTED: proteinase-activated receptor 4 [Chlorocebus sabaeus]","gi|3293321|gb|AF055917.1|AF055917",3312,0,"Homo sapiens protease-activated receptor 4 mRNA, complete cds","Q96RI0",553,0,"Proteinase-activated receptor 4",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007596|blood coagulation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0030168|platelet activation;GO:0060155|platelet dense granule organization;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0035025|positive regulation of Rho protein signal transduction;GO:0009611|response to wounding;GO:0007165|signal transduction;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0015057|thrombin receptor activity;","K04236","F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3"]
["ENSG00000091490",1713,1471,1503,974.474262859097,241,295,347,6.30803931752558,2.65719165236406,2.24522022131532e-258,6.18654394696141e-256,"up","yes","SEL1L3","protein_coding","chr4:25747427-25863760:-","gi|154689719|ref|NP_056002.2|",5738,0,"protein sel-1 homolog 3 isoform 1 [Homo sapiens]","gi|662236813|ref|NM_015187.4|",4520,0,"Homo sapiens SEL1L family member 3 (SEL1L3), transcript variant 1, mRNA","Q68CR1",2192,0,"Protein sel-1 homolog 3","SMc03995",66.2,3e-10,"COG0790","pfam08238","Sel1","Sel1 repeat. This short repeat is found in the Sel1 protein. It is related to TPR repeats.",".","GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".",".","."]
["ENSG00000167996",24928,23570,22474,14760.6405631397,3302,4408,5811,6.30272729476852,2.65597624182201,0,0,"up","yes","FTH1","protein_coding","chr11:61959718-61967660:-","gi|635015808|ref|XP_008007775.1|",1099,1e-145,"PREDICTED: LOW QUALITY PROTEIN: ferritin heavy chain [Chlorocebus sabaeus]","gi|56682958|ref|NM_002032.2|",1229,0,"Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA","P02794",382,2e-131,"Ferritin heavy chain","AF0834",89,7e-20,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006955|immune response;GO:0006880|intracellular sequestering of iron ion;GO:0097286|iron ion import;GO:0008285|negative regulation of cell proliferation;GO:0048147|negative regulation of fibroblast proliferation;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0005634|nucleus;","GO:0008199|ferric iron binding;GO:0004322|ferroxidase activity;GO:0005506|iron ion binding;","K00522","FTH1; ferritin heavy chain [EC:1.16.3.2]"]
["ENSG00000130477",31,25,15,14.4891163650047,0,5,9,6.25445204985633,2.6448834959686,2.85386636433584e-05,0.000117517878811507,"up","yes","UNC13A","protein_coding","chr19:17601328-17688365:-","gi|283837842|ref|NP_001073890.2|",8604,0,"protein unc-13 homolog A [Homo sapiens]","gi|283837841|ref|NM_001080421.2|",9838,0,"Homo sapiens unc-13 homolog A (C. elegans) (UNC13A), mRNA","Q9UPW8",3288,0,"Protein unc-13 homolog A",".",".",".",".","pfam06292","DUF1041","Domain of Unknown Function (DUF1041). This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with pfam00168, pfam00130 and pfam00169 domains.","GO:0050435|beta-amyloid metabolic process;GO:0060384|innervation;GO:0035556|intracellular signal transduction;GO:0007528|neuromuscular junction development;GO:0007269|neurotransmitter secretion;GO:1903861|positive regulation of dendrite extension;GO:1900451|positive regulation of glutamate receptor signaling pathway;GO:0001956|positive regulation of neurotransmitter secretion;GO:0031915|positive regulation of synaptic plasticity;GO:1902991|regulation of amyloid precursor protein catabolic process;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0035249|synaptic transmission, glutamatergic;GO:0016081|synaptic vesicle docking;GO:0016079|synaptic vesicle exocytosis;GO:0016188|synaptic vesicle maturation;GO:0016082|synaptic vesicle priming;","GO:0044305|calyx of Held;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0048786|presynaptic active zone;GO:0042734|presynaptic membrane;GO:0043195|terminal bouton;","GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019992|diacylglycerol binding;GO:0005543|phospholipid binding;GO:0017075|syntaxin-1 binding;","K15293","UNC13, MUNC13; protein unc-13"]
["ENSG00000185291",17,13,16,9.56539526912832,2,2,5,6.17532076208261,2.62651407594382,0.000315453658374249,0.00112238888816132,"up","yes","IL3RA","protein_coding","chrX:1336616-1382689:+","gi|1345402|dbj|BAA08393.1|",1960,0,"interleukin 3 receptor alpha subunit [Homo sapiens]","gi|391224438|ref|NM_002183.3|",1706,0,"Homo sapiens interleukin 3 receptor subunit alpha (IL3RA), transcript variant 1, mRNA","P26951",715,0,"Interleukin-3 receptor subunit alpha",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0019221|cytokine-mediated signaling pathway;GO:0000165|MAPK cascade;","GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0004912|interleukin-3 receptor activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K04737","IL3RA; interleukin 3 receptor alpha"]
["ENSG00000280208",25,5,5,7.16794109148953,5,1,0,6.14937770588224,2.62044042247429,0.00787469184775969,0.0214015860729307,"up","yes","GGT4P","unprocessed_pseudogene","chr13:18253526-18270822:-","gi|114685462|ref|XP_001171192.1|",1112,0,"PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Pan troglodytes]","gi|416525|emb|X60069.1|",1544,0,"Human mRNA for pancreatic gamma-glutamyltransferase","Q60928",342,0,"Glutathione hydrolase 1 proenzyme","ECU05g1240",122,3e-60,"COG0405","pfam01019","G_glu_transpept","Gamma-glutamyltranspeptidase.","GO:0006520|cellular amino acid metabolic process;GO:0019344|cysteine biosynthetic process;GO:0006631|fatty acid metabolic process;GO:0006536|glutamate metabolic process;GO:0006750|glutathione biosynthetic process;GO:0006751|glutathione catabolic process;GO:0006749|glutathione metabolic process;GO:1901750|leukotriene D4 biosynthetic process;GO:0031179|peptide modification;GO:0006508|proteolysis;GO:0002682|regulation of immune system process;GO:0050727|regulation of inflammatory response;GO:0007283|spermatogenesis;GO:0031638|zymogen activation;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0031982|vesicle;","GO:0036374|glutathione hydrolase activity;GO:0000048|peptidyltransferase activity;GO:0016755|transferase activity, transferring amino-acyl groups;","K18592","GGT1_5; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]"]
["ENSG00000124194",11,13,6,6.18866314190938,1,1,4,6.09280669313702,2.60710696860459,0.00445700393578563,0.0128155473931773,"up","yes","GDAP1L1","protein_coding","chr20:44247099-44280917:+","gi|376319237|ref|NP_001243666.1|",1951,0,"ganglioside-induced differentiation-associated protein 1-like 1 isoform 1 [Homo sapiens]","gi|376319236|ref|NM_001256737.1|",2855,0,"Homo sapiens ganglioside induced differentiation associated protein 1-like 1 (GDAP1L1), transcript variant 1, mRNA","Q96MZ0",703,0,"Ganglioside-induced differentiation-associated protein 1-like 1",".",".",".",".","pfam13417","GST_N_3","Glutathione S-transferase, N-terminal domain.","GO:0006749|glutathione metabolic process;","GO:0005737|cytoplasm;","GO:0004364|glutathione transferase activity;",".","."]
["ENSG00000163285",29,14,24,13.9880687240738,6,0,7,6.08672639461517,2.60566651646408,6.44971075986313e-05,0.000252110664099156,"up","yes","GABRG1","protein_coding","chr4:46035769-46124081:-","gi|31742490|ref|NP_775807.2|",2305,0,"gamma-aminobutyric acid receptor subunit gamma-1 precursor [Homo sapiens]","gi|59889570|ref|NM_173536.3|",6769,0,"Homo sapiens gamma-aminobutyric acid type A receptor gamma1 subunit (GABRG1), mRNA","Q8N1C3",891,0,"Gamma-aminobutyric acid receptor subunit gamma-1",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007268|synaptic transmission;GO:0007214|gamma-aminobutyric acid signaling pathway;","GO:0030054|cell junction;GO:0034707|chloride channel complex;GO:0045211|postsynaptic membrane;GO:0043235|receptor complex;","GO:0005254|chloride channel activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0050811|GABA receptor binding;GO:0004890|GABA-A receptor activity;","K05186","GABRG; gmma-aminobutyric acid receptor subunit gamma"]
["ENSG00000104413",119,104,103,68.1126759401402,20,14,30,6.07058336259785,2.60183516127297,9.4716820761642e-21,1.16660155737583e-19,"up","yes","ESRP1","protein_coding","chr8:94641074-94707466:+","gi|56790297|ref|NP_060167.2|",3410,0,"epithelial splicing regulatory protein 1 isoform 1 [Homo sapiens]","gi|170763523|ref|NM_017697.3|",3806,0,"Homo sapiens epithelial splicing regulatory protein 1 (ESRP1), transcript variant 1, mRNA","Q6NXG1",1319,0,"Epithelial splicing regulatory protein 1",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0006397|mRNA processing;GO:0043484|regulation of RNA splicing;GO:0008380|RNA splicing;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003729|mRNA binding;","K14947","ESRP1_2; epithelial splicing regulatory protein 1/2"]
["ENSG00000162892",26,35,22,17.2237375679987,1,5,11,6.04076384795234,2.5947309882882,4.85339831071868e-06,2.19438224606521e-05,"up","yes","IL24","protein_coding","chr1:206897443-206904139:+","gi|297632404|ref|NP_001172086.1|",757,5e-94,"interleukin-24 isoform 4 precursor [Homo sapiens]","gi|297632403|ref|NM_001185157.1|",1819,0,"Homo sapiens interleukin 24 (IL24), transcript variant 4, mRNA","Q13007",268,7e-84,"Interleukin-24",".",".",".",".","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0006915|apoptotic process;GO:0071353|cellular response to interleukin-4;GO:0071222|cellular response to lipopolysaccharide;GO:0019221|cytokine-mediated signaling pathway;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042501|serine phosphorylation of STAT protein;GO:0042060|wound healing;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005125|cytokine activity;","K05444","IL19_20_24; interleukin 19/20/24"]
["ENSG00000142549",6,6,8,4.20817756049442,1,1,2,6.03589973704575,2.59356884130723,0.0169806694168734,0.0426432669554702,"up","yes","IGLON5","protein_coding","chr19:51311848-51330354:+","gi|504175290|ref|XP_004597194.1|",1475,0,"PREDICTED: igLON family member 5, partial [Ochotona princeps]","gi|157819142|ref|NM_001101372.1|",2606,0,"Homo sapiens IgLON family member 5 (IGLON5), mRNA","A6NGN9",571,0,"IgLON family member 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005576|extracellular region;",".","K06773","OPCML, OBCAM; opioid binding protein/cell adhesion molecule-like"]
["ENSG00000136244",42,42,47,27.663554583628,10,6,10,5.95696008050938,2.57457629115398,2.63752397441912e-09,1.64211579044519e-08,"up","yes","IL6","protein_coding","chr7:22725884-22732002:+","gi|795614441|ref|XP_011729449.1|",1000,3e-130,"PREDICTED: interleukin-6 isoform X3 [Macaca nemestrina]","gi|767945478|ref|XM_011515390.1|",1527,0,"PREDICTED: Homo sapiens interleukin 6 (IL6), transcript variant X2, mRNA","P05231",370,6e-125,"Interleukin-6",".",".",".",".","pfam00489","IL6","Interleukin-6/G-CSF/MGF family.","GO:0006953|acute-phase response;GO:0044267|cellular protein metabolic process;GO:0070301|cellular response to hydrogen peroxide;GO:0071222|cellular response to lipopolysaccharide;GO:0019221|cytokine-mediated signaling pathway;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051607|defense response to virus;GO:0031018|endocrine pancreas development;GO:0070091|glucagon secretion;GO:0002384|hepatic immune response;GO:0006959|humoral immune response;GO:0006954|inflammatory response;GO:0070102|interleukin-6-mediated signaling pathway;GO:0002548|monocyte chemotaxis;GO:0043066|negative regulation of apoptotic process;GO:0045779|negative regulation of bone resorption;GO:0008285|negative regulation of cell proliferation;GO:0045079|negative regulation of chemokine biosynthetic process;GO:0032966|negative regulation of collagen biosynthetic process;GO:0045599|negative regulation of fat cell differentiation;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;GO:0010888|negative regulation of lipid storage;GO:0031175|neuron projection development;GO:0001781|neutrophil apoptotic process;GO:0002446|neutrophil mediated immunity;GO:0030168|platelet activation;GO:0002675|positive regulation of acute inflammatory response;GO:0043065|positive regulation of apoptotic process;GO:0050871|positive regulation of B cell activation;GO:0008284|positive regulation of cell proliferation;GO:0032722|positive regulation of chemokine production;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0010628|positive regulation of gene expression;GO:0051024|positive regulation of immunoglobulin secretion;GO:0032755|positive regulation of interleukin-6 production;GO:0046427|positive regulation of JAK-STAT cascade;GO:0002690|positive regulation of leukocyte chemotaxis;GO:0043410|positive regulation of MAPK cascade;GO:0045669|positive regulation of osteoblast differentiation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:2000553|positive regulation of T-helper 2 cell cytokine production;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045727|positive regulation of translation;GO:2000676|positive regulation of type B pancreatic cell apoptotic process;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043687|post-translational protein modification;GO:0045765|regulation of angiogenesis;GO:0010574|regulation of vascular endothelial growth factor production;GO:0051384|response to glucocorticoid;GO:0032494|response to peptidoglycan;GO:0072540|T-helper 17 cell lineage commitment;","GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005896|interleukin-6 receptor complex;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005138|interleukin-6 receptor binding;","K05405","IL6; interleukin 6"]
["ENSG00000156298",22,16,13,10.474998016942,0,1,10,5.904720578939,2.5618687905425,0.000722515028004293,0.00241942185071993,"up","yes","TSPAN7","protein_coding","chrX:38561370-38688920:+","gi|926729152|ref|XP_005700976.2|",1340,6e-179,"PREDICTED: tetraspanin-7 [Capra hircus]","gi|694984541|ref|XM_009438946.1|",1872,0,"PREDICTED: Pan troglodytes tetraspanin 7 (TSPAN7), transcript variant X1, mRNA","P41732",517,5e-180,"Tetraspanin-7",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007166|cell surface receptor signaling pathway;GO:0016032|viral process;","GO:0005887|integral component of plasma membrane;",".","K06571","TSPAN7, TM4SF2, MXS1; tetraspanin-7"]
["ENSG00000108448",3434,3321,2992,2048.23523425445,513,651,829,5.83326007196311,2.54430239717023,0,0,"up","yes","TRIM16L","protein_coding","chr17:18697998-18736118:+","gi|530409970|ref|XP_005256536.1|",2428,0,"PREDICTED: tripartite motif-containing protein 16-like protein isoform X2 [Homo sapiens]","gi|16550904|dbj|AK056026.1|",3001,0,"Homo sapiens cDNA FLJ31464 fis, clone NT2NE2001337, highly similar to Tripartite motif-containing protein 16","O95361",798,0,"Tripartite motif-containing protein 16",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0043966|histone H3 acetylation;GO:0043967|histone H4 acetylation;GO:0050718|positive regulation of interleukin-1 beta secretion;GO:0045618|positive regulation of keratinocyte differentiation;GO:0048386|positive regulation of retinoic acid receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060416|response to growth hormone;GO:0046683|response to organophosphorus;GO:0032526|response to retinoic acid;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016605|PML body;","GO:0003677|DNA binding;GO:0019966|interleukin-1 binding;GO:0032089|NACHT domain binding;GO:0008270|zinc ion binding;","K12006","TRIM16; tripartite motif-containing protein 16"]
["ENSG00000273012",4,10,6,4.27967328751325,2,1,1,5.82589688222936,2.54248016615164,0.0202467104750592,0.0497159200054669,"up","yes","AL353600.1","lincRNA","chr10:33341655-33341905:+",".",".",".",".","gi|551869086|tpe|HG502797.1|",251,2e-127,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000472416.1 (RP11-90B22.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam14296","O-ag_pol_Wzy","O-antigen polysaccharide polymerase Wzy. This family includes O-antigen polysaccharide polymerases. These enzymes link O-units via a glycosidic linkage to form a long O-antigen. These enzymes vary in specificity and sequence.",".",".",".",".","."]
["ENSG00000023171",464,475,470,297.826544105304,99,87,99,5.82434340464031,2.54209541967913,3.98765773692865e-71,1.69041631714021e-69,"up","yes","GRAMD1B","protein_coding","chr11:123358428-123627774:+","gi|144227752|ref|NP_065767.1|",3771,0,"GRAM domain-containing protein 1B isoform 2 [Homo sapiens]","gi|557440805|ref|NM_020716.2|",7720,0,"Homo sapiens GRAM domain containing 1B (GRAMD1B), transcript variant 2, mRNA","Q3KR37",1457,0,"GRAM domain-containing protein 1B",".",".",".",".","pfam02893","GRAM","GRAM domain. The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.",".","GO:0016021|integral component of membrane;GO:0016020|membrane;",".",".","."]
["ENSG00000267355",12,8,4,4.94743059581944,1,1,3,5.75906895578325,2.52583559613907,0.0125994055522804,0.0327825892745695,"up","yes","RPL9P29","processed_pseudogene","chr17:78845953-78846868:-","gi|466020282|ref|XP_004272075.1|",257,1e-56,"PREDICTED: 60S ribosomal protein L9-like [Orcinus orca]","gi|585866445|ref|NG_010416.2|",482,0,"Homo sapiens ribosomal protein L9 pseudogene 29 (RPL9P29) on chromosome 17","Q5IFJ7",103,9e-58,"60S ribosomal protein L9","SPAC4G9.16c",63.9,1e-15,"COG0097","pfam00347","Ribosomal_L6","Ribosomal protein L6.","GO:0006412|translation;","GO:0005840|ribosome;","GO:0019843|rRNA binding;GO:0003735|structural constituent of ribosome;","K02940","RP-L9e, RPL9; large subunit ribosomal protein L9e"]
["ENSG00000272720",31,26,27,17.5468826428164,2,4,12,5.74887835942468,2.52328050507541,4.06383511913209e-06,1.85215623293525e-05,"up","yes","AL022322.1","lincRNA","chr22:38090127-38091559:+","gi|355782636|gb|EHH64557.1|",343,1e-35,"hypothetical protein EGM_17802, partial [Macaca fascicularis]","gi|584277135|ref|NG_033059.2|",1433,0,"Homo sapiens BAI1 associated protein 2 like 2 (BAIAP2L2), RefSeqGene on chromosome 22","Q8WTZ3",133,3e-34,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000057468",9,15,9,6.96393068686306,1,3,3,5.69232908448107,2.50901906924756,0.00305495755070754,0.00911345811169232,"up","yes","MSH4","protein_coding","chr1:75796882-75913238:+","gi|36949366|ref|NP_002431.2|",4797,0,"mutS protein homolog 4 [Homo sapiens]","gi|343962632|ref|NM_002440.3|",3266,0,"Homo sapiens mutS homolog 4 (MSH4), mRNA","O15457",1848,0,"MutS protein homolog 4","YFL003c",332,6e-97,"COG0249","pfam00488","MutS_V","MutS domain V. This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam01624, pfam05188, pfam05192 and pfam05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterized in, which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.","GO:0051026|chiasma assembly;GO:0007292|female gamete generation;GO:0006298|mismatch repair;GO:0001541|ovarian follicle development;GO:0007131|reciprocal meiotic recombination;GO:0007283|spermatogenesis;","GO:0005634|nucleus;GO:0005713|recombination nodule;GO:0000795|synaptonemal complex;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0008094|DNA-dependent ATPase activity;GO:0030983|mismatched DNA binding;","K08740","MSH4; DNA mismatch repair protein MSH4"]
["ENSG00000101203",70,53,65,39.7685408112403,12,14,13,5.69081056715386,2.50863415656134,2.07730148420021e-12,1.64478616696444e-11,"up","yes","COL20A1","protein_coding","chr20:63293186-63334851:+","gi|119595693|gb|EAW75287.1|",5516,0,"collagen, type XX, alpha 1, isoform CRA_c, partial [Homo sapiens]","gi|768017765|ref|XM_011528940.1|",8037,0,"PREDICTED: Homo sapiens collagen, type XX, alpha 1 (COL20A1), transcript variant X5, mRNA","Q9P218",2085,0,"Collagen alpha-1(XX) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.",".","GO:0005581|collagen trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0005615|extracellular space;",".",".","."]
["ENSG00000130766",1540,1627,1459,977.940477031945,250,312,415,5.66121698835951,2.50111222166883,1.13662276765779e-219,2.33225318538122e-217,"up","yes","SESN2","protein_coding","chr1:28259527-28282491:+","gi|13899299|ref|NP_113647.1|",2459,0,"sestrin-2 [Homo sapiens]","gi|324072719|ref|NM_031459.4|",3453,0,"Homo sapiens sestrin 2 (SESN2), mRNA","P58004",951,0,"Sestrin-2",".",".",".",".","pfam04636","PA26","PA26 p53-induced protein (sestrin). PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.","GO:0034198|cellular response to amino acid starvation;GO:0071230|cellular response to amino acid stimulus;GO:0042149|cellular response to glucose starvation;GO:0071233|cellular response to leucine;GO:1990253|cellular response to leucine starvation;GO:0034599|cellular response to oxidative stress;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0006635|fatty acid beta-oxidation;GO:0042593|glucose homeostasis;GO:0046323|glucose import;GO:0032042|mitochondrial DNA metabolic process;GO:0030308|negative regulation of cell growth;GO:1904262|negative regulation of TORC1 signaling;GO:1902010|negative regulation of translation in response to endoplasmic reticulum stress;GO:1904504|positive regulation of lipophagy;GO:0016239|positive regulation of macroautophagy;GO:1900182|positive regulation of protein localization to nucleus;GO:0036091|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043491|protein kinase B signaling;GO:0072593|reactive oxygen species metabolic process;GO:2000479|regulation of cAMP-dependent protein kinase activity;GO:0006111|regulation of gluconeogenesis;GO:0001932|regulation of protein phosphorylation;GO:1901031|regulation of response to reactive oxygen species;GO:0009749|response to glucose;GO:0032868|response to insulin;GO:0070328|triglyceride homeostasis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0031588|nucleotide-activated protein kinase complex;GO:0005634|nucleus;GO:0031932|TORC2 complex;","GO:0005092|GDP-dissociation inhibitor activity;GO:0070728|leucine binding;GO:0016684|oxidoreductase activity, acting on peroxide as acceptor;GO:0032542|sulfiredoxin activity;",".","."]
["ENSG00000177614",7,8,8,4.86356250454938,1,1,3,5.60786198998245,2.48745084492309,0.012797356261914,0.0332464115905332,"up","yes","PGBD5","protein_coding","chr1:230314482-230426371:-","gi|385198065|ref|NP_001245240.1|",2275,0,"piggyBac transposable element-derived protein 5 [Homo sapiens]","gi|22798015|emb|AL691479.15|",9139,0,"Human DNA sequence from clone RP11-421G1 on chromosome 1, complete sequence","Q8N414",880,0,"PiggyBac transposable element-derived protein 5",".",".",".",".","pfam13843","DDE_Tnp_1_7","Transposase IS4.","GO:0032196|transposition;","GO:0005634|nucleus;","GO:0004519|endonuclease activity;",".","."]
["ENSG00000115008",418,363,406,251.2103006111,60,85,109,5.59599077245362,2.484393583563,1.78756811772481e-65,6.74728255473114e-64,"up","yes","IL1A","protein_coding","chr2:112773915-112784590:-","gi|27894330|ref|NP_000566.3|",1451,0,"interleukin-1 alpha precursor [Homo sapiens]","gi|940517012|ref|NM_000575.4|",2124,0,"Homo sapiens interleukin 1 alpha (IL1A), mRNA","P01583",563,0,"Interleukin-1 alpha",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0006915|apoptotic process;GO:0008283|cell proliferation;GO:0034605|cellular response to heat;GO:0002248|connective tissue replacement involved in inflammatory response wound healing;GO:0019221|cytokine-mediated signaling pathway;GO:0035234|ectopic germ cell programmed cell death;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0001660|fever generation;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0045766|positive regulation of angiogenesis;GO:0051781|positive regulation of cell division;GO:0050715|positive regulation of cytokine secretion;GO:0010628|positive regulation of gene expression;GO:0045086|positive regulation of interleukin-2 biosynthetic process;GO:0032755|positive regulation of interleukin-6 production;GO:0045840|positive regulation of mitotic nuclear division;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:2000391|positive regulation of neutrophil extravasation;GO:0050714|positive regulation of protein secretion;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0046688|response to copper ion;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005507|copper ion binding;GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;","K04383","IL1A; interleukin 1 alpha"]
["ENSG00000135902",18,6,5,6.0039109061247,2,2,2,5.57973649547995,2.48019699201133,0.00799738709543001,0.0217166834149872,"up","yes","CHRND","protein_coding","chr2:232525993-232536667:+","gi|767916448|ref|XP_011508826.1|",1647,0,"PREDICTED: acetylcholine receptor subunit delta isoform X1 [Homo sapiens]","gi|767916447|ref|XM_011510524.1|",2820,0,"PREDICTED: Homo sapiens cholinergic receptor, nicotinic, delta (muscle) (CHRND), transcript variant X1, mRNA","Q07001",546,0,"Acetylcholine receptor subunit delta",".",".",".",".","pfam02932","Neur_chan_memb","Neurotransmitter-gated ion-channel transmembrane region. This family includes the four transmembrane helices that form the ion channel.","GO:0098655|cation transmembrane transport;GO:0006936|muscle contraction;GO:0050881|musculoskeletal movement;GO:0050905|neuromuscular process;GO:0007274|neuromuscular synaptic transmission;GO:0035094|response to nicotine;GO:0007165|signal transduction;GO:0003009|skeletal muscle contraction;GO:0048630|skeletal muscle tissue growth;GO:0007271|synaptic transmission, cholinergic;","GO:0005892|acetylcholine-gated channel complex;GO:0030054|cell junction;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;","GO:0042166|acetylcholine binding;GO:0022848|acetylcholine-gated cation channel activity;GO:0015276|ligand-gated ion channel activity;GO:0004888|transmembrane signaling receptor activity;","K04816","CHRND; nicotinic acetylcholine receptor delta"]
["ENSG00000115274",19,19,19,12.1609840875147,6,1,5,5.56626995262432,2.47671087810327,0.00014825260216975,0.000552452896184338,"up","yes","INO80B","protein_coding","chr2:74455023-74457960:+","gi|795184348|ref|XP_011801455.1|",1139,1e-150,"PREDICTED: INO80 complex subunit B isoform X1 [Colobus angolensis palliatus]","gi|323276648|ref|NM_031288.3|",1261,0,"Homo sapiens INO80 complex subunit B (INO80B), mRNA","Q9C086",417,3e-142,"INO80 complex subunit B",".",".",".",".","pfam04795","PAPA-1","PAPA-1-like conserved region. Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein.","GO:0006338|chromatin remodeling;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0016579|protein deubiquitination;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0031011|Ino80 complex;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;","K11666","INO80B, ZNHIT4, PAPA1; INO80 complex subunit B"]
["ENSG00000197322",8,3,12,4.92217910430179,2,0,3,5.5500723245018,2.47250657173666,0.0184752360589224,0.0458800506121405,"up","yes","C17orf102","bidirectional_promoter_lncRNA","chr17:34574123-34579369:-","gi|149944524|ref|NP_997337.2|",794,1e-94,"uncharacterized protein C17orf102 [Homo sapiens]","gi|149944523|ref|NM_207454.2|",3997,0,"Homo sapiens chromosome 17 open reading frame 102 (C17orf102), mRNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSG00000140961",810,821,715,497.271238678643,121,166,225,5.4877884476244,2.45622486718021,1.15808513526965e-120,1.00166574390498e-118,"up","yes","OSGIN1","protein_coding","chr16:83948282-83966332:+","gi|334302887|sp|Q9UJX0.3|OSGI1_HUMAN",2834,0,"RecName: Full=Oxidative stress-induced growth inhibitor 1; AltName: Full=Ovary, kidney and liver protein 38; Short=huOKL38; AltName: Full=Pregnancy-induced growth inhibitor OKL38","gi|30144628|gb|AY258066.1|",2375,0,"Homo sapiens OKL382b (OKL38) mRNA, complete cds","Q9UJX0",1097,0,"Oxidative stress-induced growth inhibitor 1",".",".",".",".","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0030308|negative regulation of cell growth;GO:0043065|positive regulation of apoptotic process;",".","GO:0008083|growth factor activity;",".","."]
["ENSG00000143333",88,97,79,55.9463803563362,10,15,35,5.37643778550176,2.4266506167732,9.35370980750361e-15,8.57482674748715e-14,"up","yes","RGS16","protein_coding","chr1:182598623-182604408:-","gi|675745643|ref|XP_002760338.2|",971,1e-122,"PREDICTED: regulator of G-protein signaling 16 isoform X1 [Callithrix jacchus]","gi|156416008|ref|NM_002928.3|",2427,0,"Homo sapiens regulator of G-protein signaling 16 (RGS16), mRNA","O15492",374,7e-123,"Regulator of G-protein signaling 16",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;GO:0007601|visual perception;","GO:0005737|cytoplasm;GO:0031224|intrinsic component of membrane;GO:0005886|plasma membrane;","GO:0005516|calmodulin binding;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSG00000243697",17,4,16,7.91084329253655,4,1,3,5.37053005283388,2.4250644842734,0.00392455924028511,0.0114138870064263,"up","yes","AC009108.1","processed_pseudogene","chr16:86525457-86526252:+","gi|586466338|ref|XP_006863786.1|",1005,1e-134,"PREDICTED: 60S ribosomal protein L7a [Chrysochloris asiatica]","gi|224493618|ref|NG_011041.1|",796,0,"Homo sapiens ribosomal protein L7a pseudogene 63 (RPL7AP63) on chromosome 16","P62425",390,1e-135,"60S ribosomal protein L7a","SPBC29A3.04",236,1e-75,"COG1358","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:1904401|cellular response to Thyroid stimulating hormone;GO:0000470|maturation of LSU-rRNA;GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;GO:0005840|ribosome;","GO:0003723|RNA binding;","K02936","RP-L7Ae, RPL7A; large subunit ribosomal protein L7Ae"]
["ENSG00000136010",582,564,514,353.845052115756,103,120,146,5.34710514870603,2.41875804704235,1.29244518544173e-92,7.6703639190154e-91,"up","yes","ALDH1L2","protein_coding","chr12:105019784-105084577:-","gi|238814322|ref|NP_001029345.2|",4875,0,"mitochondrial 10-formyltetrahydrofolate dehydrogenase precursor [Homo sapiens]","gi|238814321|ref|NM_001034173.3|",7533,0,"Homo sapiens aldehyde dehydrogenase 1 family member L2 (ALDH1L2), transcript variant 1, mRNA","Q3SY69",1882,0,"Mitochondrial 10-formyltetrahydrofolate dehydrogenase","BS_dhaS",422,1e-129,"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0009258|10-formyltetrahydrofolate catabolic process;GO:0009058|biosynthetic process;GO:0046655|folic acid metabolic process;GO:0006730|one-carbon metabolic process;","GO:0070062|extracellular exosome;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016155|formyltetrahydrofolate dehydrogenase activity;GO:0016742|hydroxymethyl-, formyl- and related transferase activity;","K00289","E1.5.1.6, FTHFD; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]"]
["ENSG00000197168",9,10,11,6.37389147916544,0,3,4,5.3140578241232,2.40981392638354,0.00628435756331907,0.0175112234442788,"up","yes","NEK5","protein_coding","chr13:52033611-52129078:-","gi|767977648|ref|XP_011533369.1|",822,1e-91,"PREDICTED: serine/threonine-protein kinase Nek5 isoform X10 [Homo sapiens]","gi|12227312|emb|AL139082.18|",3608,0,"Human DNA sequence from clone RP11-248G5 on chromosome 13q14.3-21.1, complete sequence","Q7TSC3",97.4,3e-19,"Serine/threonine-protein kinase Nek5",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:2001056|positive regulation of cysteine-type endopeptidase activity;GO:0051155|positive regulation of striated muscle cell differentiation;",".","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K08857","NEK; NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]"]
["ENSG00000166750",2712,2326,2426,1593.13012309406,435,606,636,5.28865202334882,2.4029000537108,1.91277100123296e-292,6.47254860908446e-290,"up","yes","SLFN5","protein_coding","chr17:35243036-35273655:+","gi|119600565|gb|EAW80159.1|",4786,0,"likely ortholog of mouse schlafen 5 [Homo sapiens]","gi|21427857|gb|AC022706.7|",8586,0,"Homo sapiens chromosome , clone RP11-47L3, complete sequence","Q08AF3",1820,0,"Schlafen family member 5",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0030154|cell differentiation;","GO:0005634|nucleus;","GO:0005524|ATP binding;",".","."]
["ENSG00000161040",629,547,515,361.010016643466,117,115,148,5.26557928962813,2.39659225723398,8.17326344632131e-88,4.5562400390938e-86,"up","yes","FBXL13","protein_coding","chr7:102813230-103074843:-","gi|530385609|ref|XP_005250262.1|",3947,0,"PREDICTED: F-box/LRR-repeat protein 13 isoform X2 [Homo sapiens]","gi|161333851|ref|NM_145032.3|",2744,0,"Homo sapiens F-box and leucine-rich repeat protein 13 (FBXL13), transcript variant 1, mRNA","Q8NEE6",1520,0,"Dynein regulatory complex subunit 6",".",".",".",".","pfam08457","Sfi1","Sfi1 spindle body protein. This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.","GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0031514|motile cilium;","GO:0004842|ubiquitin-protein transferase activity;","K10279","FBXL13; F-box and leucine-rich repeat protein 13"]
["ENSG00000183775",11,12,8,6.60399638971719,2,2,3,5.26443429589401,2.39627851086031,0.00466335755689498,0.0133710183673837,"up","yes","KCTD16","protein_coding","chr5:144170832-144485686:+","gi|55926200|ref|NP_065819.1|",2120,0,"BTB/POZ domain-containing protein KCTD16 [Homo sapiens]","gi|767937810|ref|XM_005268492.2|",13879,0,"PREDICTED: Homo sapiens potassium channel tetramerization domain containing 16 (KCTD16), transcript variant X1, mRNA","Q68DU8",821,0,"BTB/POZ domain-containing protein KCTD16",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;","GO:0030054|cell junction;GO:0045211|postsynaptic membrane;GO:0042734|presynaptic membrane;GO:0043235|receptor complex;",".",".","."]
["ENSG00000101307",8,5,10,4.98903978676792,2,3,0,5.26333494858522,2.39597720810955,0.0186363717437012,0.046208810668789,"up","yes","SIRPB1","protein_coding","chr20:1563521-1620061:-","gi|144953876|ref|NP_006056.2|",1889,0,"signal-regulatory protein beta-1 isoform 1 precursor [Homo sapiens]","gi|2052057|emb|Y10376.1|",3114,0,"H.sapiens mRNA for SIRP-beta1","O00241",732,0,"Signal-regulatory protein beta-1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0007166|cell surface receptor signaling pathway;GO:0045087|innate immune response;GO:0043312|neutrophil degranulation;GO:0007165|signal transduction;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;",".",".","."]
["ENSG00000115902",870,945,867,575.829129951402,178,202,232,5.20322866935067,2.37940711167535,9.58131781338067e-125,8.63572233572366e-123,"up","yes","SLC1A4","protein_coding","chr2:64988477-65023865:+","gi|507137|gb|AAA19438.1|",1571,0,"neutral amino acid transporter [Homo sapiens]","gi|34533192|dbj|AK126636.1|",5777,0,"Homo sapiens cDNA FLJ44678 fis, clone BRACE3009392, highly  similar to Neutral amino acid transporter A","P43007",608,0,"Neutral amino acid transporter A","MA2961",123,2e-28,"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0006865|amino acid transport;GO:0050890|cognition;GO:0006868|glutamine transport;GO:0034589|hydroxyproline transport;GO:0015808|L-alanine transport;GO:0015811|L-cystine transport;GO:0015825|L-serine transport;GO:0015824|proline transport;GO:0035249|synaptic transmission, glutamatergic;GO:0015826|threonine transport;","GO:0009986|cell surface;GO:0005813|centrosome;GO:0030425|dendrite;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005882|intermediate filament;GO:0042470|melanosome;GO:0016020|membrane;GO:0005815|microtubule organizing center;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0005254|chloride channel activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015184|L-cystine transmembrane transporter activity;GO:0015186|L-glutamine transmembrane transporter activity;GO:0034590|L-hydroxyproline transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;GO:0015194|L-serine transmembrane transporter activity;GO:0015195|L-threonine transmembrane transporter activity;GO:0015293|symporter activity;","K05615","SLC1A4, SATT; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4"]
["ENSG00000224596",339,310,377,220.240124735141,48,93,97,5.18621047114767,2.37468075604071,1.47170256454642e-46,3.96455294203511e-45,"up","yes","ZMIZ1-AS1","antisense","chr10:78943328-79067895:-","gi|119575021|gb|EAW54636.1|",315,2e-30,"hCG1815393 [Homo sapiens]","gi|551870200|tpe|HG503058.1|",2878,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000048940.1 (RP11-202P11.1 gene), antisense",".",".",".",".",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.",".",".",".",".","."]
["ENSG00000151012",16073,14424,14403,9619.46381164121,2927,3381,3958,5.17747612742122,2.37224899640708,0,0,"up","yes","SLC7A11","protein_coding","chr4:138164097-138242349:-","gi|7657683|ref|NP_055146.1|",2537,0,"cystine/glutamate transporter [Homo sapiens]","gi|80861465|ref|NM_014331.3|",9642,0,"Homo sapiens solute carrier family 7 member 11 (SLC7A11), mRNA","Q9UPY5",981,0,"Cystine/glutamate transporter","BS_ykbA",164,2e-41,"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0007420|brain development;GO:0070306|lens fiber cell differentiation;GO:0050900|leukocyte migration;GO:0070527|platelet aggregation;GO:0035094|response to nicotine;GO:0006979|response to oxidative stress;GO:0009636|response to toxic substance;","GO:0009986|cell surface;GO:0005856|cytoskeleton;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0005791|rough endoplasmic reticulum;","GO:0015327|cystine:glutamate antiporter activity;","K13869","SLC7A11; solute carrier family 7 (L-type amino acid transporter), member 11"]
["ENSG00000147676",21,9,23,11.4308229012189,4,5,3,5.16997664265086,2.37015776262766,0.000456900546760343,0.00158132024868356,"up","yes","MAL2","protein_coding","chr8:119165034-119245673:+","gi|16418397|ref|NP_443118.1|",708,9e-84,"protein MAL2 [Homo sapiens]","gi|109633023|ref|NM_052886.2|",2818,0,"Homo sapiens mal, T-cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA","Q969L2",277,3e-85,"Protein MAL2",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001766|membrane raft polarization;GO:0042552|myelination;GO:0008104|protein localization;GO:0045056|transcytosis;","GO:0016324|apical plasma membrane;GO:0012505|endomembrane system;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0019911|structural constituent of myelin sheath;",".","."]
["ENSG00000237596",15,14,13,8.92780824047181,1,3,6,5.14947770786006,2.36442611258874,0.00127067978357575,0.00407733682675247,"up","yes","AL138828.1","antisense","chr6:135991936-136225751:-","gi|593733639|ref|XP_007112283.1|",307,1e-29,"PREDICTED: cytochrome c oxidase subunit 5B, mitochondrial-like [Physeter catodon]","gi|229577399|ref|NG_011994.1|",1267,0,"Homo sapiens phosphodiesterase 7B (PDE7B), RefSeqGene on chromosome 6","Q5S3G4",119,9e-30,"Cytochrome c oxidase subunit 5B, mitochondrial",".",".",".",".","pfam01215","COX5B","Cytochrome c oxidase subunit Vb.","GO:0042776|mitochondrial ATP synthesis coupled proton transport;GO:0006123|mitochondrial electron transport, cytochrome c to oxygen;","GO:0005751|mitochondrial respiratory chain complex IV;","GO:0004129|cytochrome-c oxidase activity;GO:0046872|metal ion binding;","K02265","COX5B; cytochrome c oxidase subunit 5b"]
["ENSG00000078081",222,169,180,122.091292981661,31,51,50,5.14377159290443,2.36282658179881,6.00457853939889e-31,1.09882647882283e-29,"up","yes","LAMP3","protein_coding","chr3:183122213-183163839:-","gi|38455385|ref|NP_055213.2|",1741,0,"lysosome-associated membrane glycoprotein 3 precursor [Homo sapiens]","gi|156627583|ref|NM_014398.3|",3341,0,"Homo sapiens lysosomal associated membrane protein 3 (LAMP3), mRNA","Q9UQV4",675,0,"Lysosome-associated membrane glycoprotein 3",".",".",".",".","pfam01299","Lamp","Lysosome-associated membrane glycoprotein (Lamp).","GO:0002250|adaptive immune response;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1901799|negative regulation of proteasomal protein catabolic process;GO:0010628|positive regulation of gene expression;GO:0010506|regulation of autophagy;GO:1903900|regulation of viral life cycle;GO:0035455|response to interferon-alpha;","GO:0097233|alveolar lamellar body membrane;GO:0005769|early endosome;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005765|lysosomal membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0031982|vesicle;",".","K06562","LAMP3; lysosomal-associated membrane protein 3"]
["ENSG00000137809",14,20,16,10.7207485676625,1,5,6,5.09904607494124,2.3502273742067,0.000509457321374336,0.00175065255917837,"up","yes","ITGA11","protein_coding","chr15:68296533-68432162:-","gi|52485853|ref|NP_001004439.1|",6322,0,"integrin alpha-11 precursor [Homo sapiens]","gi|767983624|ref|XM_005254228.2|",8926,0,"PREDICTED: Homo sapiens integrin, alpha 11 (ITGA11), transcript variant X2, mRNA","Q9UKX5",2438,0,"Integrin alpha-11",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007155|cell adhesion;GO:0033627|cell adhesion mediated by integrin;GO:0007160|cell-matrix adhesion;GO:0038065|collagen-activated signaling pathway;GO:0030198|extracellular matrix organization;GO:0007229|integrin-mediated signaling pathway;GO:0007517|muscle organ development;GO:0001649|osteoblast differentiation;GO:0006929|substrate-dependent cell migration;","GO:0005925|focal adhesion;GO:0034681|integrin alpha11-beta1 complex;GO:0008305|integrin complex;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005518|collagen binding;GO:0098639|collagen binding involved in cell-matrix adhesion;GO:0038064|collagen receptor activity;GO:0046872|metal ion binding;","K06587","ITGA11; integrin alpha 11"]
["ENSG00000234975",140,135,139,89.2117782910343,29,29,39,5.07537655722197,2.34351486408763,5.87453343470837e-24,8.28512992466527e-23,"up","yes","FTH1P2","processed_pseudogene","chr1:228687415-228687826:+","gi|304445747|pdb|3AJQ|A",696,4e-91,"Chain A, Crystal Structure Of Human H Ferritin E140q Mutant","gi|615276346|ref|NG_007330.2|",412,0,"Homo sapiens ferritin, heavy polypeptide 1 pseudogene 2 (FTH1P2) on chromosome 1","P02794",271,2e-92,"Ferritin heavy chain","TM1128",53.5,4e-09,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006955|immune response;GO:0006880|intracellular sequestering of iron ion;GO:0097286|iron ion import;GO:0008285|negative regulation of cell proliferation;GO:0048147|negative regulation of fibroblast proliferation;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0005634|nucleus;","GO:0008199|ferric iron binding;GO:0004322|ferroxidase activity;GO:0005506|iron ion binding;","K00522","FTH1; ferritin heavy chain [EC:1.16.3.2]"]
["ENSG00000138622",18,11,11,8.60679756680618,4,4,1,5.05531765156555,2.33780174691369,0.00222158064573574,0.0068080469486735,"up","yes","HCN4","protein_coding","chr15:73319859-73369264:-","gi|5734516|emb|CAB52754.1|",4134,0,"hyperpolarization-activated channel type 4 [Homo sapiens]","gi|210147528|ref|NM_005477.2|",7228,0,"Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA","Q9Y3Q4",1596,0,"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4","mll3241_2",70.1,3e-12,"COG0664","pfam08412","Ion_trans_N","Ion transport protein N-terminal. This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.","GO:0008015|blood circulation;GO:0006812|cation transport;GO:0071320|cellular response to cAMP;GO:0071321|cellular response to cGMP;GO:0086012|membrane depolarization during cardiac muscle cell action potential;GO:0086046|membrane depolarization during SA node cell action potential;GO:0006936|muscle contraction;GO:1990573|potassium ion import across plasma membrane;GO:0071805|potassium ion transmembrane transport;GO:0098909|regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:0055117|regulation of cardiac muscle contraction;GO:0002027|regulation of heart rate;GO:0086091|regulation of heart rate by cardiac conduction;GO:0034765|regulation of ion transmembrane transport;GO:0003254|regulation of membrane depolarization;GO:0042391|regulation of membrane potential;GO:0086015|SA node cell action potential;GO:0098719|sodium ion import across plasma membrane;GO:0035725|sodium ion transmembrane transport;","GO:0098855|HCN channel complex;GO:0031226|intrinsic component of plasma membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0030552|cAMP binding;GO:0042802|identical protein binding;GO:0005222|intracellular cAMP activated cation channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0086041|voltage-gated potassium channel activity involved in SA node cell action potential depolarization;GO:0005248|voltage-gated sodium channel activity;","K04957","HCN4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4"]
["ENSG00000232187",93,98,84,59.1287652127335,13,29,23,5.04676389373403,2.33535859360942,1.03764660346982e-15,9.97216127938511e-15,"up","yes","FTH1P7","processed_pseudogene","chr13:22696023-22696574:-","gi|931583940|ref|XP_014202872.1|",944,6e-128,"PREDICTED: ferritin heavy chain [Pan paniscus]","gi|271397498|ref|NG_007331.2|",552,0,"Homo sapiens ferritin, heavy polypeptide 1 pseudogene 7 (FTH1P7) on chromosome 13","P02794",358,1e-125,"Ferritin heavy chain","AF0834",81.6,2e-18,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006955|immune response;GO:0006880|intracellular sequestering of iron ion;GO:0097286|iron ion import;GO:0008285|negative regulation of cell proliferation;GO:0048147|negative regulation of fibroblast proliferation;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0005634|nucleus;","GO:0008199|ferric iron binding;GO:0004322|ferroxidase activity;GO:0005506|iron ion binding;","K00522","FTH1; ferritin heavy chain [EC:1.16.3.2]"]
["ENSG00000169302",194,183,175,118.900035659017,45,26,59,5.04165714844888,2.33389801287108,5.23927061285562e-27,8.44941902849157e-26,"up","yes","STK32A","protein_coding","chr5:147234963-147387852:+","gi|163310763|ref|NP_001106195.1|",2027,0,"serine/threonine-protein kinase 32A isoform 1 [Homo sapiens]","gi|426350506|ref|XM_004042765.1|",5160,0,"PREDICTED: Gorilla gorilla gorilla serine/threonine kinase 32A, transcript variant 1 (STK32A), mRNA","Q8WU08",785,0,"Serine/threonine-protein kinase 32A",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;","GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;","K08793","STK32, YANK; serine/threonine kinase 32 [EC:2.7.11.1]"]
["ENSG00000255693",10,6,9,5.34193226904444,0,4,2,5.04096449633461,2.33369979343826,0.0154632304384546,0.0393268445011751,"up","yes","LINC02389","lincRNA","chr12:64883394-64990607:+",".",".",".",".","gi|551874123|tpe|HG504889.1|",3546,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000401253.1 (RP11-766N7.3 gene), lincRNA",".",".",".",".",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSG00000133067",20,35,21,16.4385741812226,6,4,8,5.03263195707671,2.33131309552701,2.56555870638873e-05,0.000106303966334749,"up","yes","LGR6","protein_coding","chr1:202193901-202319781:+","gi|62912470|ref|NP_001017403.1|",4144,0,"leucine-rich repeat-containing G-protein coupled receptor 6 isoform 1 precursor [Homo sapiens]","gi|62912469|ref|NM_001017403.1|",3458,0,"Homo sapiens leucine-rich repeat containing G protein-coupled receptor 6 (LGR6), transcript variant 1, mRNA","Q9HBX8",1600,0,"Leucine-rich repeat-containing G-protein coupled receptor 6","alr0124_1",100,4e-21,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:1990523|bone regeneration;GO:0007186|G-protein coupled receptor signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0030335|positive regulation of cell migration;GO:0030177|positive regulation of Wnt signaling pathway;GO:0016055|Wnt signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0032588|trans-Golgi network membrane;GO:0031982|vesicle;","GO:0016500|protein-hormone receptor activity;GO:0004888|transmembrane signaling receptor activity;","K08399","LGR6; leucine-rich repeat-containing G protein-coupled receptor 6"]
["ENSG00000276851",23,23,29,16.2181969164822,4,6,8,5.01975790751421,2.32761778767192,1.74098768546577e-05,7.38512656196697e-05,"up","yes","AC002401.4","lincRNA","chr17:50094065-50094647:+",".",".",".",".","gi|666671851|tpe|LK938137.1|",583,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473570.1 (RP5-875H18.9 gene), lincRNA",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSG00000151790",28,34,19,17.4281224930094,5,9,5,5.00437220069617,2.32318909408595,1.46215579713001e-05,6.25877963050235e-05,"up","yes","TDO2","protein_coding","chr4:155854738-155920406:+","gi|667299912|ref|XP_008580788.1|",849,6e-122,"PREDICTED: tryptophan 2,3-dioxygenase [Galeopterus variegatus]","gi|34366369|emb|BX647341.1|",3123,0,"Homo sapiens mRNA; cDNA DKFZp779D1612 (from clone DKFZp779D1612)","P48775",352,5e-109,"Tryptophan 2,3-dioxygenase","RSp0694",62.8,2e-09,"COG3483","pfam03301","Trp_dioxygenase","Tryptophan 2,3-dioxygenase.","GO:0051289|protein homotetramerization;GO:0006569|tryptophan catabolic process;GO:0019442|tryptophan catabolic process to acetyl-CoA;GO:0019441|tryptophan catabolic process to kynurenine;","GO:0005829|cytosol;","GO:0016597|amino acid binding;GO:0020037|heme binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0019825|oxygen binding;GO:0004833|tryptophan 2,3-dioxygenase activity;","K00453","E1.13.11.11, TDO2; tryptophan 2,3-dioxygenase [EC:1.13.11.11]"]
["ENSG00000230606",10,6,8,5.1036419169501,1,0,5,4.98204732625474,2.31673872632157,0.0199534425451495,0.0490645078800157,"up","yes","AC092683.1","lincRNA","chr2:97416165-97433527:-","gi|2072977|gb|AAC51279.1|",326,2e-41,"putative p150 [Homo sapiens]","gi|666670863|tpe|LK937770.1|",2830,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000476581.2 (RP11-734K23.9 gene), lincRNA","O00370",128,2e-42,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["ENSG00000168890",252,254,245,162.076406546689,42,69,69,4.97961314672991,2.31603366739921,4.16247234771691e-40,9.80290190998337e-39,"up","yes","TMEM150A","protein_coding","chr2:85598548-85603196:-","gi|578802692|ref|XP_006711995.1|",980,3e-124,"PREDICTED: transmembrane protein 150A isoform X4 [Homo sapiens]","gi|21758101|dbj|AK098152.1|",2317,0,"Homo sapiens cDNA FLJ40833 fis, clone TRACH2012811, highly similar to Rattus norvegicus TM6P1 (TM6P1) mRNA","Q86TG1",343,4e-110,"Transmembrane protein 150A",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.","GO:0009056|catabolic process;GO:0046854|phosphatidylinositol phosphorylation;GO:0072659|protein localization to plasma membrane;","GO:0005887|integral component of plasma membrane;GO:0005764|lysosome;",".",".","."]
["ENSG00000087086",183034,185308,168807,116059.093405681,32767,42872,54980,4.93372128938975,2.3026762187243,0,0,"up","yes","FTL","protein_coding","chr19:48965301-48966878:+","gi|33096741|emb|CAE11873.1|",1215,2e-166,"hypothetical protein [Homo sapiens]","gi|21751414|dbj|AK092744.1|",870,0,"Homo sapiens cDNA FLJ35425 fis, clone SMINT2001615, highly similar to FERRITIN LIGHT CHAIN","P02792",336,4e-115,"Ferritin light chain","ECU06g1380",55.5,1e-08,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006880|intracellular sequestering of iron ion;GO:0055072|iron ion homeostasis;GO:0006826|iron ion transport;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0035578|azurophil granule lumen;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0016020|membrane;","GO:0008199|ferric iron binding;GO:0042802|identical protein binding;GO:0005506|iron ion binding;","K13625","FTL; ferritin light chain"]
["ENSG00000167995",15,13,15,9.36726743242655,3,7,0,4.92642261560419,2.30054039545435,0.0025171614643525,0.00762780994885012,"up","yes","BEST1","protein_coding","chr11:61949821-61965515:+","gi|62088482|dbj|BAD92688.1|",1897,0,"bestrophin variant [Homo sapiens]","gi|62088481|dbj|AB209451.1|",5710,0,"Homo sapiens mRNA for bestrophin variant protein","O76090",456,2e-140,"Bestrophin-1",".",".",".",".","pfam01062","Bestrophin","Bestrophin, RFP-TM, chloride channel. Bestrophin is a 68-kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterized by a depressed light peak in the electrooculogram. VMD2 encodes a 585-amino acid protein with an approximate mass of 68 kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif. Bestrophin is a plasma membrane protein, localized to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of chloride channels, indicating a direct role for bestrophin in generating the light peak. The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal RFP-TM domain implying important functional properties. The bestrophins are four-pass transmembrane chloride-channel proteins, and the RFP-TM or bestrophin domain extends from the N-terminus through approximately 350 amino acids and contains all of the TM domains as well as nearly all reported disease causing mutations. Interestingly, the RFP motif is not conserved evolutionarily back beyond Metazoa, neither is it in plant members.","GO:0006821|chloride transport;GO:0050908|detection of light stimulus involved in visual perception;GO:0034220|ion transmembrane transport;GO:0051924|regulation of calcium ion transport;GO:0030321|transepithelial chloride transport;GO:0007601|visual perception;","GO:0016323|basolateral plasma membrane;GO:0034707|chloride channel complex;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0015106|bicarbonate transmembrane transporter activity;GO:0005254|chloride channel activity;GO:0042802|identical protein binding;GO:0005229|intracellular calcium activated chloride channel activity;","K13878","BEST1, VMD2; bestrophin-1"]
["ENSG00000111644",13,14,11,8.25834777119033,5,0,4,4.91620965003339,2.29754644024561,0.00357981785609476,0.0105063187474674,"up","yes","ACRBP","protein_coding","chr12:6638075-6647460:-","gi|189053479|dbj|BAG35645.1|",2459,0,"unnamed protein product [Homo sapiens]","gi|17999523|ref|NM_032489.2|",1886,0,"Homo sapiens acrosin binding protein (ACRBP), mRNA","Q8NEB7",951,0,"Acrosin-binding protein",".",".",".",".","pfam07222","PBP_sp32","Proacrosin binding protein sp32. This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix.","GO:0048240|sperm capacitation;","GO:0002080|acrosomal membrane;GO:0001669|acrosomal vesicle;GO:0005576|extracellular region;GO:0005634|nucleus;",".",".","."]
["ENSG00000101255",3931,3655,3515,2399.3476841279,689,903,1117,4.88934849651419,2.28964223951957,0,0,"up","yes","TRIB3","protein_coding","chr20:362835-397559:+","gi|668259520|ref|NP_001288130.1|",1760,0,"tribbles homolog 3 isoform 2 [Homo sapiens]","gi|668259454|ref|NM_021158.4|",2487,0,"Homo sapiens tribbles pseudokinase 3 (TRIB3), transcript variant 1, mRNA","Q96RU7",679,0,"Tribbles homolog 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0032869|cellular response to insulin stimulus;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0045599|negative regulation of fat cell differentiation;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0006469|negative regulation of protein kinase activity;GO:0051898|negative regulation of protein kinase B signaling;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032092|positive regulation of protein binding;GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0006468|protein phosphorylation;GO:0010827|regulation of glucose transport;GO:0019216|regulation of lipid metabolic process;GO:0043405|regulation of MAP kinase activity;GO:0034976|response to endoplasmic reticulum stress;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0031434|mitogen-activated protein kinase kinase binding;GO:0019901|protein kinase binding;GO:0004860|protein kinase inhibitor activity;GO:0003714|transcription corepressor activity;GO:0031625|ubiquitin protein ligase binding;GO:0055106|ubiquitin-protein transferase regulator activity;","K19518","TRIB3; tribbles homolog 3"]
["ENSG00000163395",16,19,11,9.96734400810465,4,4,3,4.87522079847922,2.28546755992019,0.000950239210562853,0.00312501515657908,"up","yes","IGFN1","protein_coding","chr1:201190825-201228952:+","gi|257196151|ref|NP_001158058.1|",16969,0,"immunoglobulin-like and fibronectin type III domain-containing protein 1 [Homo sapiens]","gi|257196150|ref|NM_001164586.1|",11810,0,"Homo sapiens immunoglobulin-like and fibronectin type III domain containing 1 (IGFN1), mRNA","Q86VF2",1632,0,"Immunoglobulin-like and fibronectin type III domain-containing protein 1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".","GO:0005634|nucleus;GO:0030018|Z disc;",".",".","."]
["ENSG00000228063",63,40,55,34.0411486896684,7,15,17,4.86870325599101,2.28353757204749,2.33537829808983e-09,1.4624927471934e-08,"up","yes","LYPLAL1-DT","antisense","chr1:219086602-219173961:-",".",".",".",".","gi|551899322|tpe|HG493219.1|",724,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000098809.1 (RP11-135J2.4 gene), antisense",".",".",".",".",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSG00000203808",16,10,7,7.04782649428669,2,3,3,4.85561489273616,2.27965400347752,0.00534023821042972,0.0151052228483309,"up","yes","BVES-AS1","antisense","chr6:105136308-105169945:+","gi|74744851|sp|Q5T3Y7.1|BVAS1_HUMAN",269,3e-39,"RecName: Full=Putative uncharacterized protein BVES-AS1; AltName: Full=BVES antisense RNA 1; AltName: Full=BVES antisense gene protein 1","gi|551859876|tpe|HG499481.1|",1346,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000041649.1 (C6orf112 gene), antisense",".",".",".",".",".",".",".",".","pfam06881","Elongin_A","RNA polymerase II transcription factor SIII (Elongin) subunit A. This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.",".",".",".",".","."]
["ENSG00000181085",22,11,15,10.2501438390195,1,5,6,4.85387157947576,2.27913593912268,0.000985811516607102,0.00323153170161757,"up","yes","MAPK15","protein_coding","chr8:143716259-143722458:+","gi|20380832|gb|AAH28034.1|",1341,6e-178,"MAPK15 protein [Homo sapiens]","gi|20380831|gb|BC028034.1|",2237,0,"Homo sapiens mitogen-activated protein kinase 15, mRNA (cDNA clone MGC:40087 IMAGE:5242481), complete cds","Q8TD08",496,8e-166,"Mitogen-activated protein kinase 15",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0090494|dopamine uptake;GO:0007029|endoplasmic reticulum organization;GO:0030336|negative regulation of cell migration;GO:0051973|positive regulation of telomerase activity;GO:1904355|positive regulation of telomere capping;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0046777|protein autophosphorylation;GO:1904491|protein localization to ciliary transition zone;GO:0010506|regulation of autophagy;GO:1902017|regulation of cilium assembly;GO:0003400|regulation of COPII vesicle coating;GO:0010468|regulation of gene expression;","GO:0005776|autophagosome;GO:0005911|cell-cell junction;GO:0005814|centriole;GO:0036064|ciliary basal body;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0005622|intracellular;GO:0072687|meiotic spindle;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0004707|MAP kinase activity;GO:0004672|protein kinase activity;GO:0017124|SH3 domain binding;","K19603","MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]"]
["ENSG00000147174",89,77,78,52.615721110523,9,24,28,4.83465157828929,2.27341192188687,1.34835603602949e-13,1.15381948637696e-12,"up","yes","GCNA","protein_coding","chrX:71578411-71613583:+","gi|16445033|ref|NP_443189.1|",1916,0,"acidic repeat-containing protein [Homo sapiens]","gi|34534593|dbj|AK127607.1|",3207,0,"Homo sapiens cDNA FLJ45705 fis, clone FEBRA2028222, highly similar to Homo sapiens acidic repeat containing (ACRC), mRNA","Q96QF7",723,0,"Acidic repeat-containing protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0080111|DNA demethylation;","GO:0005634|nucleus;",".",".","."]
["ENSG00000219507",94,74,81,53.7820605155579,13,21,28,4.81988875632416,2.26899984924538,2.39277441729888e-14,2.13863915481283e-13,"up","yes","FTH1P8","processed_pseudogene","chrX:148052233-148052746:+","gi|686736046|ref|XP_009244536.1|",469,1e-86,"PREDICTED: ferritin heavy chain isoform X1 [Pongo abelii]","gi|222418748|ref|NG_007336.2|",514,0,"Homo sapiens ferritin, heavy polypeptide 1 pseudogene 8 (FTH1P8) on chromosome X","P02794",179,9e-87,"Ferritin heavy chain","AF0834",60.5,3e-11,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006955|immune response;GO:0006880|intracellular sequestering of iron ion;GO:0097286|iron ion import;GO:0008285|negative regulation of cell proliferation;GO:0048147|negative regulation of fibroblast proliferation;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0005634|nucleus;","GO:0008199|ferric iron binding;GO:0004322|ferroxidase activity;GO:0005506|iron ion binding;","K00522","FTH1; ferritin heavy chain [EC:1.16.3.2]"]
["ENSG00000185250",24,27,9,12.8197324825582,3,4,8,4.80888324009934,2.26570189793859,0.000366842208785881,0.00128976531590632,"up","yes","PPIL6","protein_coding","chr6:109390215-109441171:-","gi|795548961|ref|XP_011905857.1|",1726,0,"PREDICTED: peptidyl-prolyl cis-trans isomerase-like 6 isoform X1 [Cercocebus atys]","gi|289803021|ref|NM_173672.4|",4128,0,"Homo sapiens peptidylprolyl isomerase like 6 (PPIL6), transcript variant 1, mRNA","Q8IXY8",651,0,"Problable inactive peptidyl-prolyl cis-trans isomerase-like 6","slr1251",162,6e-44,"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.",".",".","GO:0003755|peptidyl-prolyl cis-trans isomerase activity;","K12739","PPIL6; peptidyl-prolyl cis-trans isomerase-like 6 [EC:5.2.1.8]"]
["ENSG00000254554",20,11,16,10.2989297484885,6,5,0,4.75373692636558,2.24906206618961,0.00222575450558725,0.00681975423411706,"up","yes","AC080023.1","antisense","chr11:10302657-10303704:-","gi|795194595|ref|XP_011803010.1|",313,7e-49,"PREDICTED: uncharacterized protein LOC105515743 [Colobus angolensis palliatus]","gi|551870416|tpe|HG503525.1|",803,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000386929.1 (RP11-351I24.1 gene), antisense",".",".",".",".",".",".",".",".","pfam12287","Caprin-1_C","Cytoplasmic activation/proliferation-associated protein-1 C term. This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteristic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.",".",".",".",".","."]
["ENSG00000261824",582,540,510,355.237845714211,123,133,152,4.7336904449252,2.24296536552051,6.34729792059879e-81,3.09940967829138e-79,"up","yes","LINC00662","lincRNA","chr19:27684580-27793940:-",".",".",".",".","gi|551888819|tpe|HG510548.1|",2480,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000431033.1 (CTC-459F4.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam04276","DUF443","Protein of unknown function (DUF443). Family of uncharacterized proteins.",".",".",".",".","."]
["ENSG00000231290",204,159,178,117.897242944036,44,36,57,4.67998363180133,2.22650348400519,4.45189709683141e-27,7.19766900282349e-26,"up","yes","APCDD1L-DT","processed_transcript","chr20:58515379-58619888:+",".",".",".",".","gi|426392277|ref|XR_177007.1|",2498,0,"PREDICTED: Gorilla gorilla gorilla uncharacterized LOC101129187 (LOC101129187), misc_RNA",".",".",".",".",".",".",".",".","pfam11982","DUF3483","Domain of unknown function (DUF3483). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 230 amino acids in length. This domain is found associated with pfam02754.",".",".",".",".","."]
["ENSG00000105499",15,5,15,7.61706606851545,2,3,4,4.66618404977967,2.22224321312316,0.00564227773329565,0.015867194051723,"up","yes","PLA2G4C","protein_coding","chr19:48047843-48110817:-","gi|226693363|ref|NP_001152795.1|",2615,0,"cytosolic phospholipase A2 gamma isoform 3 [Homo sapiens]","gi|226693362|ref|NM_001159323.1|",2496,0,"Homo sapiens phospholipase A2 group IVC (PLA2G4C), transcript variant 3, mRNA","Q9UP65",1011,0,"Cytosolic phospholipase A2 gamma",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0019369|arachidonic acid metabolic process;GO:0046475|glycerophospholipid catabolic process;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0007567|parturition;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0036149|phosphatidylinositol acyl-chain remodeling;GO:0006644|phospholipid metabolic process;","GO:0005938|cell cortex;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;","GO:0047499|calcium-independent phospholipase A2 activity;GO:0004622|lysophospholipase activity;GO:0008970|phosphatidylcholine 1-acylhydrolase activity;GO:0004623|phospholipase A2 activity;GO:0005543|phospholipid binding;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSG00000260231",38,34,28,21.8193374695284,8,11,6,4.66245710790719,2.22109045341201,2.18732866470426e-06,1.02750110289371e-05,"up","yes","KDM7A-DT","bidirectional_promoter_lncRNA","chr7:140177184-140179640:+","gi|355561739|gb|EHH18371.1|",225,2e-18,"hypothetical protein EGK_14950, partial [Macaca mulatta]","gi|3980553|gb|AC004849.1|",2457,0,"Homo sapiens PAC clone RP4-659J6 from 7, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000157152",52,62,48,35.5029975773034,13,16,12,4.643799766686,2.21530576681223,1.83413115755857e-09,1.16103451811584e-08,"up","yes","SYN2","protein_coding","chr3:12004402-12191400:+","gi|3511273|gb|AAC33789.1|",2202,0,"synapsin IIb [Homo sapiens]","gi|586946412|ref|NM_003178.5|",3865,0,"Homo sapiens synapsin II (SYN2), transcript variant IIb, mRNA","Q92777",780,0,"Synapsin-2",".",".",".",".","pfam02750","Synapsin_C","Synapsin, ATP binding domain. Ca dependent ATP binding in this ATP grasp fold. Function unknown.","GO:0007268|synaptic transmission;GO:0007269|neurotransmitter secretion;","GO:0030054|cell junction;GO:0045202|synapse;GO:0030672|synaptic vesicle membrane;","GO:0005524|ATP binding;",".","."]
["ENSG00000169429",3296,3084,3027,2054.8210008665,689,744,980,4.63501152182236,2.21257292514106,0,0,"up","yes","CXCL8","protein_coding","chr4:73740506-73743716:+","gi|297673722|ref|XP_002814903.1|",417,1e-45,"PREDICTED: interleukin-8 [Pongo abelii]","gi|324073503|ref|NM_000584.3|",1705,0,"Homo sapiens C-X-C motif chemokine ligand 8 (CXCL8), mRNA","P10145",165,6e-47,"Interleukin-8",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001525|angiogenesis;GO:0019722|calcium-mediated signaling;GO:0007050|cell cycle arrest;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071347|cellular response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0019221|cytokine-mediated signaling pathway;GO:0048566|embryonic digestive tract development;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0050930|induction of positive chemotaxis;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0031640|killing of cells of other organism;GO:0008285|negative regulation of cell proliferation;GO:0045744|negative regulation of G-protein coupled receptor protein signaling pathway;GO:0042119|neutrophil activation;GO:0030593|neutrophil chemotaxis;GO:0036499|PERK-mediated unfolded protein response;GO:0045766|positive regulation of angiogenesis;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0030155|regulation of cell adhesion;GO:2000535|regulation of entry of bacterium into host cell;GO:0045091|regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0034976|response to endoplasmic reticulum stress;GO:0002237|response to molecule of bacterial origin;GO:0007165|signal transduction;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005622|intracellular;","GO:0008009|chemokine activity;GO:0005153|interleukin-8 receptor binding;","K10030","IL8, CXCL8; interleukin 8"]
["ENSG00000228775",9,13,8,6.50800305370728,1,2,5,4.61328818305511,2.2057954175452,0.00927520185413595,0.0248127730045179,"up","yes","WEE2-AS1","antisense","chr7:141704338-141738346:-","gi|119604382|gb|EAW83976.1|",668,1e-79,"hypothetical protein FLJ40852 [Homo sapiens]","gi|213417881|ref|NR_015392.1|",2262,0,"Homo sapiens WEE2 antisense RNA 1 (WEE2-AS1), long non-coding RNA","P0C1S8",114,5e-25,"Wee1-like protein kinase 2",".",".",".",".","pfam01407","Gemini_AL3","Geminivirus AL3 protein. Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL3 protein comprises approximately 0.05% of the cellular proteins and is present in the soluble and organelle fractions. AL3 may form oligomers. Immunoprecipitation of AL3 in a baculovirus expression system extracts expressing both AL1 pfam00799 and AL3 showed that the two proteins also complex with each other. The AL3 protein is involved in viral replication.","GO:0007143|female meiotic division;GO:0035038|female pronucleus assembly;GO:0000278|mitotic cell cycle;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:1900194|negative regulation of oocyte maturation;GO:0060631|regulation of meiosis I;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;","K06632","WEE1; wee1-like protein kinase [EC:2.7.11.1]"]
["ENSG00000113739",165,133,132,93.7166059838106,27,42,42,4.60302321668655,2.20258171923225,1.1286381022664e-22,1.50860510855955e-21,"up","yes","STC2","protein_coding","chr5:173314713-173329503:-","gi|4507267|ref|NP_003705.1|",1617,0,"stanniocalcin-2 precursor [Homo sapiens]","gi|61676085|ref|NM_003714.2|",5343,0,"Homo sapiens stanniocalcin 2 (STC2), mRNA","O76061",627,0,"Stanniocalcin-2",".",".",".",".","pfam03298","Stanniocalcin","Stanniocalcin family.","GO:0006874|cellular calcium ion homeostasis;GO:0044267|cellular protein metabolic process;GO:0071456|cellular response to hypoxia;GO:0046697|decidualization;GO:0007566|embryo implantation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0010629|negative regulation of gene expression;GO:0040015|negative regulation of multicellular organism growth;GO:0043687|post-translational protein modification;GO:0046885|regulation of hormone biosynthetic process;GO:2001256|regulation of store-operated calcium entry;GO:0006979|response to oxidative stress;GO:0043434|response to peptide hormone;GO:0033280|response to vitamin D;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0048471|perinuclear region of cytoplasm;","GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0005179|hormone activity;GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000041515",105,93,103,65.9656814898504,22,26,30,4.58660438143737,2.19742647281053,1.04908191607391e-16,1.06274642842613e-15,"up","yes","MYO16","protein_coding","chr13:108596152-109208007:+","gi|312147315|ref|NP_001185879.1|",8979,0,"unconventional myosin-XVI isoform 1 [Homo sapiens]","gi|312147314|ref|NM_001198950.1|",7427,0,"Homo sapiens myosin XVI (MYO16), transcript variant 1, mRNA","Q9Y6X6",3418,0,"Unconventional myosin-XVI","YAL029c",339,1e-93,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0021549|cerebellum development;GO:0008285|negative regulation of cell proliferation;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005737|cytoplasm;GO:0016459|myosin complex;GO:0005654|nucleoplasm;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0003774|motor activity;","K17481","MYO16; myosin XVI"]
["ENSG00000167103",197,155,157,111.045292947414,37,40,55,4.58175391047352,2.19589997246323,2.02927619811051e-26,3.19515749462494e-25,"up","yes","PIP5KL1","protein_coding","chr9:127920879-127930797:-","gi|206725454|ref|NP_001128691.1|",2034,0,"phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1 [Homo sapiens]","gi|931576885|ref|XM_003822307.3|",2134,0,"PREDICTED: Pan paniscus phosphatidylinositol-4-phosphate 5-kinase-like 1 (PIP5KL1), transcript variant X1, mRNA","Q5T9C9",788,0,"Phosphatidylinositol 4-phosphate 5-kinase-like protein 1","SPAC19G12.14",127,1e-29,"COG5253","pfam01504","PIP5K","Phosphatidylinositol-4-phosphate 5-Kinase. This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.",".","GO:0042995|cell projection;GO:0005829|cytosol;GO:0016020|membrane;","GO:0016308|1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0005524|ATP binding;","K13712","PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68]"]
["ENSG00000198431",64125,61575,58592,40338.8400170554,12604,15903,19599,4.57041290687574,2.19232450922042,0,0,"up","yes","TXNRD1","protein_coding","chr12:104215779-104350305:+","gi|387598068|ref|NP_001248374.1|",2810,0,"thioredoxin reductase 1, cytoplasmic isoform 4 [Homo sapiens]","gi|387598067|ref|NM_001261445.1|",4269,0,"Homo sapiens thioredoxin reductase 1 (TXNRD1), transcript variant 6, mRNA","Q16881",1076,0,"Thioredoxin reductase 1, cytoplasmic","HI0161",269,7e-78,"COG1249","pfam07992","Pyr_redox_2","Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.","GO:0008283|cell proliferation;GO:0045454|cell redox homeostasis;GO:0034599|cellular response to oxidative stress;GO:0001707|mesoderm formation;GO:0015949|nucleobase-containing small molecule interconversion;GO:0019216|regulation of lipid metabolic process;GO:0000305|response to oxygen radical;GO:0001887|selenium compound metabolic process;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0001650|fibrillar center;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;","GO:0009055|electron carrier activity;GO:0050660|flavin adenine dinucleotide binding;GO:0098626|methylseleninic acid reductase activity;GO:0098625|methylselenol reductase activity;GO:0015035|protein disulfide oxidoreductase activity;GO:0004791|thioredoxin-disulfide reductase activity;",".","."]
["ENSG00000261270",11,8,14,7.20352656396802,1,2,6,4.556097572062,2.18779864371474,0.00720866984711378,0.0198007439491784,"up","yes","AC012181.2","sense_intronic","chr16:56940278-56941342:+","gi|119601568|gb|EAW81162.1|",151,7e-10,"hCG1814203 [Homo sapiens]","gi|551883380|tpe|HG508132.1|",601,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000432330.1 (RP11-325K4.3 gene), sense_intronic",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000234465",123,125,111,78.6703114890239,20,39,36,4.5134960718535,2.1742453517992,1.03223417895042e-18,1.16091736697351e-17,"up","yes","PINLYP","protein_coding","chr19:43576800-43583964:+","gi|4096056|gb|AAC99796.1|",526,1e-57,"R28379_1 [Homo sapiens]","gi|34526112|dbj|AK129550.1|",2506,0,"Homo sapiens cDNA FLJ26039 fis, clone PRS00963","A6NC86",204,6e-59,"phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005576|extracellular region;","GO:0004859|phospholipase inhibitor activity;",".","."]
["ENSG00000184005",534,575,479,347.907994378276,99,137,186,4.51276811060454,2.17401264731263,8.73264056297761e-70,3.57611828404909e-68,"up","yes","ST6GALNAC3","protein_coding","chr1:76074719-76634601:+","gi|397472625|ref|XP_003807840.1|",1626,0,"PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1 [Pan paniscus]","gi|767903621|ref|XM_006710553.2|",6700,0,"PREDICTED: Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3), transcript variant X1, mRNA","Q8NDV1",590,0,"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0009100|glycoprotein metabolic process;GO:0006687|glycosphingolipid metabolic process;GO:0006677|glycosylceramide metabolic process;GO:0009311|oligosaccharide metabolic process;GO:0018279|protein N-linked glycosylation via asparagine;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;","GO:0001665|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0008373|sialyltransferase activity;","K03373","SIAT7C, ST6GalNAc III; N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7C) [EC:2.4.99.-]"]
["ENSG00000223685",5,14,10,6.39416325597244,1,2,5,4.51090264757644,2.1734161507493,0.0128941482280113,0.0334637151536439,"up","yes","LINC00571","lincRNA","chr13:38050817-38143232:-","gi|119629007|gb|EAX08602.1|",118,6e-06,"hCG2036928, isoform CRA_a [Homo sapiens]","gi|551875269|tpe|HG505551.1|",525,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000044595.1 (RP11-196I2.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam04279","IspA","Intracellular septation protein A.",".",".",".",".","."]
["ENSG00000204334",25,30,17,15.7096152627712,2,12,5,4.51089618967603,2.17341408535612,0.000167901601859252,0.000620875401967265,"up","yes","ERICH2","protein_coding","chr2:170783786-170798971:+","gi|152061038|gb|AAI50547.1|",634,1e-80,"LOC285141 protein [Homo sapiens]","gi|584277034|ref|NM_001289947.1|",601,0,"Homo sapiens glutamate rich 2 (ERICH2), transcript variant 2, mRNA",".",".",".",".",".",".",".",".","pfam14853","Fis1_TPR_C","Fis1 C-terminal tetratricopeptide repeat. The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat",".",".",".",".","."]
["ENSG00000130707",2411,2234,2170,1495.56603669747,466,587,761,4.48469060667882,2.16500845881082,1.56189571590553e-291,5.19411113248033e-289,"up","yes","ASS1","protein_coding","chr9:130444929-130501274:+","gi|426363327|ref|XP_004048794.1|",2552,0,"PREDICTED: argininosuccinate synthase isoform 3 [Gorilla gorilla gorilla]","gi|10440175|dbj|AK027126.1|",1954,0,"Homo sapiens cDNA: FLJ23473 fis, clone HSI13532, highly similar to HSASD Human mRNA for argininosuccinate synthetase","P00966",833,0,"Argininosuccinate synthase","TM1780",482,6e-164,"COG0137","pfam00764","Arginosuc_synth","Arginosuccinate synthase. This family contains a PP-loop motif.","GO:0006953|acute-phase response;GO:0007568|aging;GO:0006526|arginine biosynthetic process;GO:0000053|argininosuccinate metabolic process;GO:0006531|aspartate metabolic process;GO:0071418|cellular response to amine stimulus;GO:0071230|cellular response to amino acid stimulus;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071549|cellular response to dexamethasone stimulus;GO:0071377|cellular response to glucagon stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071499|cellular response to laminar fluid shear stress;GO:0071222|cellular response to lipopolysaccharide;GO:0071400|cellular response to oleic acid;GO:0071356|cellular response to tumor necrosis factor;GO:0007623|circadian rhythm;GO:0000052|citrulline metabolic process;GO:0060539|diaphragm development;GO:0001822|kidney development;GO:0001889|liver development;GO:0007494|midgut development;GO:1903038|negative regulation of leukocyte cell-cell adhesion;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0032355|response to estradiol;GO:0060416|response to growth hormone;GO:0010046|response to mycotoxin;GO:0007584|response to nutrient;GO:0010043|response to zinc ion;GO:0000050|urea cycle;","GO:0070852|cell body fiber;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0070062|extracellular exosome;GO:0005764|lysosome;GO:0005741|mitochondrial outer membrane;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0043204|perikaryon;","GO:0016597|amino acid binding;GO:0004055|argininosuccinate synthase activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0003723|RNA binding;GO:0015643|toxic substance binding;","K01940","argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]"]
["ENSG00000257954",6,8,12,5.79555262208304,2,2,3,4.47461785371908,2.16176447699456,0.0153923253207965,0.0391775100009927,"up","yes","AC125611.2","processed_pseudogene","chr12:49389516-49390162:+","gi|512967213|ref|XP_004845785.1|",327,1e-60,"PREDICTED: FGFR1 oncogene partner 2 isoform X2 [Heterocephalus glaber]","gi|288541338|ref|NR_033267.1|",647,0,"Homo sapiens FGFR1 oncogene partner 2 pseudogene (LOC100335030), non-coding RNA","Q5R561",130,1e-60,"FGFR1 oncogene partner 2 homolog",".",".",".",".","pfam05769","DUF837","Protein of unknown function (DUF837). This family consists of several eukaryotic proteins of unknown function. One of the family members is a circulating cathodic antigen (CCA) found in Schistosoma mansoni (Blood fluke).",".","GO:0005737|cytoplasm;",".",".","."]
["ENSG00000266980",7,7,12,5.7831084837859,2,2,3,4.4658213962912,2.15892555392853,0.0153061736289629,0.0389788060411192,"up","yes","AC087289.1","antisense","chr17:75818815-75820055:-","gi|148702601|gb|EDL34548.1|",149,7e-08,"zinc finger CCCH type containing 5, isoform CRA_c [Mus musculus]","gi|551886166|tpe|HG509455.1|",890,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000448844.1 (RP11-552F3.4 gene), antisense","Q9C0B0",57.8,6e-08,"RING finger protein unkempt homolog",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0048667|cell morphogenesis involved in neuron differentiation;GO:2000766|negative regulation of cytoplasmic translation;GO:0001764|neuron migration;","GO:0005737|cytoplasm;GO:0005844|polysome;","GO:0046872|metal ion binding;GO:1990715|mRNA CDS binding;GO:0003723|RNA binding;",".","."]
["ENSG00000279141",94,79,73,53.8310115750926,11,27,29,4.41529578505515,2.14251008868653,7.74640299630993e-13,6.31765839293133e-12,"up","yes","LINC01451","lincRNA","chr9:136612024-136617181:-","gi|37547463|gb|AAM98770.1|",734,1e-86,"unknown [Homo sapiens]","gi|1001184460|ref|NR_135288.1|",3402,0,"Homo sapiens long intergenic non-protein coding RNA 1451 (LINC01451), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15462","Barttin","Bartter syndrome, infantile, with sensorineural deafness (Barttin). Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.",".",".",".",".","."]
["ENSG00000166922",74,59,59,42.0321791607129,10,15,28,4.38534662126435,2.13269087893357,2.34119489444628e-10,1.60244737842725e-09,"up","yes","SCG5","protein_coding","chr15:32641676-32697098:+","gi|221139785|ref|NP_001138229.1|",1064,6e-142,"neuroendocrine protein 7B2 isoform 1 precursor [Homo sapiens]","gi|221139784|ref|NM_001144757.1|",1237,0,"Homo sapiens secretogranin V (SCG5), transcript variant 1, mRNA","P05408",414,2e-143,"Neuroendocrine protein 7B2",".",".",".",".","pfam05281","Secretogranin_V","Neuroendocrine protein 7B2 precursor (Secretogranin V). The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.","GO:0006886|intracellular protein transport;GO:0007218|neuropeptide signaling pathway;GO:0016486|peptide hormone processing;GO:0046883|regulation of hormone secretion;","GO:0005576|extracellular region;GO:0030141|secretory granule;","GO:0004857|enzyme inhibitor activity;GO:0005525|GTP binding;GO:0051082|unfolded protein binding;",".","."]
["ENSG00000101280",113,114,106,73.5958581159183,21,43,26,4.37487967504969,2.1292433381801,1.0697251303056e-15,1.02753278452861e-14,"up","yes","ANGPT4","protein_coding","chr20:869899-916317:-","gi|7705276|ref|NP_057069.1|",2369,0,"angiopoietin-4 precursor [Homo sapiens]","gi|982274317|ref|XM_005568577.2|",3875,0,"PREDICTED: Macaca fascicularis angiopoietin 4 (ANGPT4), transcript variant X1, mRNA","Q9Y264",917,0,"Angiopoietin-4",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001525|angiogenesis;GO:0071456|cellular response to hypoxia;GO:0050900|leukocyte migration;GO:0016525|negative regulation of angiogenesis;GO:0043066|negative regulation of apoptotic process;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0007219|Notch signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0010595|positive regulation of endothelial cell migration;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0030971|receptor tyrosine kinase binding;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;","K05467","ANGPT4; angiopoietin 4"]
["ENSG00000186832",16,8,10,7.47979971101466,4,2,3,4.37201911393167,2.12829970830949,0.00696510544553635,0.0192028235896948,"up","yes","KRT16","protein_coding","chr17:41609778-41615899:-","gi|635092418|ref|XP_008010895.1|",1691,0,"PREDICTED: keratin, type I cytoskeletal 16 isoform X1 [Chlorocebus sabaeus]","gi|163659905|ref|NM_005557.3|",1644,0,"Homo sapiens keratin 16 (KRT16), mRNA","P08779",638,0,"Keratin, type I cytoskeletal 16",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007568|aging;GO:0008283|cell proliferation;GO:0070268|cornification;GO:0007010|cytoskeleton organization;GO:0008544|epidermis development;GO:0061436|establishment of skin barrier;GO:0042633|hair cycle;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0045104|intermediate filament cytoskeleton organization;GO:0031424|keratinization;GO:0030216|keratinocyte differentiation;GO:0051546|keratinocyte migration;GO:0002009|morphogenesis of an epithelium;GO:0030336|negative regulation of cell migration;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005882|intermediate filament;GO:0005634|nucleus;","GO:0005200|structural constituent of cytoskeleton;","K07604","KRT1; type I keratin, acidic"]
["ENSG00000186952",13,12,18,9.51871844220438,2,4,6,4.36778772631929,2.12690274324767,0.00219079033239698,0.00672223416024069,"up","yes","TMEM232","protein_coding","chr5:110289233-110738956:-","gi|767936315|ref|XP_011541865.1|",1533,0,"PREDICTED: transmembrane protein 232 isoform X9 [Homo sapiens]","gi|34531043|dbj|AK125070.1|",4193,0,"Homo sapiens cDNA FLJ43080 fis, clone BRTHA3017047","C9JQI7",594,0,"Transmembrane protein 232",".",".",".",".","pfam14752","RBP_receptor","Retinol binding protein receptor. Proteins in this family function as retinol binding protein receptors.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000134955",404,391,328,247.337293929775,80,102,124,4.36713951364225,2.1266886205216,2.26921441775497e-53,6.99179036576005e-52,"up","yes","SLC37A2","protein_coding","chr11:125063067-125090312:+","gi|18676548|dbj|BAB84926.1|",2019,0,"FLJ00171 protein [Homo sapiens]","gi|18676547|dbj|AK074100.1|",4614,0,"Homo sapiens mRNA for FLJ00171 protein","Q8TED4",677,0,"Glucose-6-phosphate exchanger SLC37A2","PA1569",73.2,2e-12,"COG2271","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0008643|carbohydrate transport;GO:0015760|glucose-6-phosphate transport;GO:0035435|phosphate ion transmembrane transport;","GO:0005789|endoplasmic reticulum membrane;GO:0070062|extracellular exosome;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0061513|glucose 6-phosphate:inorganic phosphate antiporter activity;","K13783","SLC37A1_2; MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2"]
["ENSG00000131737",64,70,58,42.6254286962616,15,25,12,4.31746664226549,2.11018503120549,1.08765531614979e-09,7.03039401404059e-09,"up","yes","KRT34","protein_coding","chr17:41377650-41382403:-","gi|14917119|ref|NP_066293.2|",2181,0,"keratin, type I cuticular Ha4 [Homo sapiens]","gi|27371163|gb|BC041070.1|",1727,0,"Homo sapiens keratin 34, mRNA (cDNA clone MGC:52152 IMAGE:5481838), complete cds","O76011",844,0,"Keratin, type I cuticular Ha4",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0070268|cornification;GO:0008544|epidermis development;GO:0031424|keratinization;","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005882|intermediate filament;","GO:0005198|structural molecule activity;","K07604","KRT1; type I keratin, acidic"]
["ENSG00000271303",124,127,149,88.7407037804366,25,35,52,4.3135661509304,2.10888108067626,4.8405707656669e-19,5.54423568457145e-18,"up","yes","SRXN1","protein_coding","chr20:646615-653370:-","gi|21758427|dbj|BAC05302.1|",709,1e-84,"unnamed protein product [Homo sapiens]","gi|425905339|ref|NM_080725.2|",2698,0,"Homo sapiens sulfiredoxin 1 (SRXN1), mRNA","Q9BYN0",209,1e-61,"Sulfiredoxin-1","SPBC106.02c",79.7,4e-16,"COG5119","pfam02195","ParBc","ParB-like nuclease domain.","GO:0034599|cellular response to oxidative stress;GO:0006979|response to oxidative stress;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0016667|oxidoreductase activity, acting on a sulfur group of donors;GO:0032542|sulfiredoxin activity;","K12260","SRX1; sulfiredoxin [EC:1.8.98.2]"]
["ENSG00000153714",602,518,546,368.82864858549,122,176,160,4.30768410244571,2.10691245588369,1.8326143021926e-68,7.3183156647393e-67,"up","yes","LURAP1L","protein_coding","chr9:12775021-12822131:+","gi|397466476|ref|XP_003804982.1|",770,4e-95,"PREDICTED: leucine rich adaptor protein 1-like [Pan paniscus]","gi|42822875|ref|NM_203403.1|",1753,0,"Homo sapiens leucine rich adaptor protein 1-like (LURAP1L), mRNA","Q8IV03",295,2e-94,"Leucine rich adaptor protein 1-like",".",".",".",".","pfam14854","LURAP","Leucine rich adaptor protein. This family of proteins activate the canonical NF-kappa-B pathway, promote proinflammatory cytokine production and promote the antigen presenting and priming functions of dendritic cells.","GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;",".",".",".","."]
["ENSG00000126500",34,23,35,20.5533203620041,10,9,6,4.26932294102135,2.094007295354,1.69964727611701e-05,7.21770071812964e-05,"up","yes","FLRT1","protein_coding","chr11:64103188-64119173:+","gi|34577057|ref|NP_037412.2|",3260,0,"leucine-rich repeat transmembrane protein FLRT1 [Homo sapiens]","gi|530396501|ref|XM_005273861.1|",3947,0,"PREDICTED: Homo sapiens fibronectin leucine rich transmembrane protein 1 (FLRT1), transcript variant X1, mRNA","Q9NZU1",1259,0,"Leucine-rich repeat transmembrane protein FLRT1","SPy1798",75.5,1e-12,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007155|cell adhesion;GO:0019221|cytokine-mediated signaling pathway;GO:0016358|dendrite development;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0046426|negative regulation of JAK-STAT cascade;GO:0006469|negative regulation of protein kinase activity;GO:1990138|neuron projection extension;GO:0051965|positive regulation of synapse assembly;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0030659|cytoplasmic vesicle membrane;GO:0005789|endoplasmic reticulum membrane;GO:0031012|extracellular matrix;GO:0005615|extracellular space;GO:0005925|focal adhesion;GO:0005887|integral component of plasma membrane;GO:0044306|neuron projection terminus;GO:0032809|neuronal cell body membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0005104|fibroblast growth factor receptor binding;GO:0030674|protein binding, bridging;GO:0004860|protein kinase inhibitor activity;","K16362","FLRT; leucine-rich repeat transmembrane protein FLRT"]
["ENSG00000077984",20,10,3,7.15940333327043,4,1,4,4.20757567443894,2.07298921906705,0.0162580285874078,0.0411474682317179,"up","yes","CST7","protein_coding","chr20:24949230-24959928:+","gi|3986157|dbj|BAA34941.1|",902,1e-119,"human CMAP [Homo sapiens]","gi|262263313|ref|NM_003650.3|",930,0,"Homo sapiens cystatin F (CST7), mRNA","O76096",308,4e-104,"Cystatin-F",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0006955|immune response;GO:2000117|negative regulation of cysteine-type endopeptidase activity;","GO:0005737|cytoplasm;GO:0005615|extracellular space;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0004866|endopeptidase inhibitor activity;GO:0002020|protease binding;","K13903","CST7; cystatin-F"]
["ENSG00000100156",63,52,53,37.211176312491,11,15,22,4.19649873188913,2.06918614485179,2.40567697717786e-09,1.50456217690682e-08,"up","yes","SLC16A8","protein_coding","chr22:38078134-38084093:-","gi|114796626|ref|NP_037488.2|",1754,0,"monocarboxylate transporter 3 [Homo sapiens]","gi|114796625|ref|NM_013356.2|",1875,0,"Homo sapiens solute carrier family 16 member 8 (SLC16A8), mRNA","O95907",680,0,"Monocarboxylate transporter 3",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015727|lactate transport;GO:0050900|leukocyte migration;GO:0006090|pyruvate metabolic process;","GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0015129|lactate transmembrane transporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08185","SLC16A8; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 8"]
["ENSG00000108846",3116,2685,2459,1833.28256757545,670,780,876,4.19323461948608,2.06806355398575,4.45803999392164e-238,1.02365089765191e-235,"up","yes","ABCC3","protein_coding","chr17:50634777-50692252:+","gi|62087488|dbj|BAD92191.1|",8043,0,"ATP-binding cassette, sub-family C, member 3 isoform MRP3 variant [Homo sapiens]","gi|221316554|ref|NM_003786.3|",5166,0,"Homo sapiens ATP binding cassette subfamily C member 3 (ABCC3), transcript variant 1, mRNA","O15438",3094,0,"Canalicular multispecific organic anion transporter 2","YDR135c",996,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0015721|bile acid and bile salt transport;GO:0015722|canalicular bile acid transport;GO:0006855|drug transmembrane transport;GO:0055085|transmembrane transport;GO:0042908|xenobiotic transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0015432|bile acid-exporting ATPase activity;GO:0008514|organic anion transmembrane transporter activity;GO:0008559|xenobiotic-transporting ATPase activity;","K05667","ABCC3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3"]
["ENSG00000173212",10,14,8,7.13864353273353,3,3,3,4.18250186297912,2.06436618287215,0.00912274546584532,0.0244626045523738,"up","yes","MAB21L3","protein_coding","chr1:116111755-116135240:+","gi|282721057|ref|NP_689580.2|",1923,0,"protein mab-21-like 3 [Homo sapiens]","gi|282721056|ref|NM_152367.2|",3229,0,"Homo sapiens mab-21-like 3 (C. elegans) (MAB21L3), mRNA",".",".",".",".",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.",".",".",".",".","."]
["ENSG00000166046",241,239,230,158.220930155037,58,62,82,4.18226634616455,2.0642849423806,4.01683089796554e-34,7.97084715637442e-33,"up","yes","TCP11L2","protein_coding","chr12:106301929-106347015:+","gi|119618182|gb|EAW97776.1|",1206,6e-154,"t-complex 11 (mouse) like 2, isoform CRA_c [Homo sapiens]","gi|23393250|gb|AF306858.1|",3162,0,"Homo sapiens clone J42-4d mRNA sequence",".",".",".",".",".",".",".",".","pfam05794","Tcp11","T-complex protein 11. This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants.",".",".",".",".","."]
["ENSG00000233621",43,32,50,27.7912578975394,3,16,18,4.15368202174136,2.05439077727653,2.44545848265076e-06,1.14374401584306e-05,"up","yes","LINC01137","antisense","chr1:37454879-37474411:-","gi|119627754|gb|EAX07349.1|",416,3e-46,"hCG1816917 [Homo sapiens]","gi|551895977|tpe|HG491913.1|",1395,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000012168.1 (RP11-422J8.1 gene), antisense",".",".",".",".",".",".",".",".","pfam04262","Glu_cys_ligase","Glutamate-cysteine ligase. Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that carry out the first step of the glutathione biosynthesis pathway.",".",".",".",".","."]
["ENSG00000249628",30,28,30,19.8903330019018,15,4,5,4.12658418640732,2.04494807308422,0.000108839515339691,0.000413003456988385,"up","yes","LINC00942","lincRNA","chr12:1500525-1504424:+","gi|119609337|gb|EAW88931.1|",404,3e-43,"hCG2003440 [Homo sapiens]","gi|257467521|ref|NR_028415.1|",2210,0,"Homo sapiens long intergenic non-protein coding RNA 942 (LINC00942), long non-coding RNA","Q86U02",68.6,5e-12,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000221926",1722,1735,1521,1110.92422204213,387,452,606,4.10802928195453,2.03844646519555,3.68009996148852e-187,5.86626182290832e-185,"up","yes","TRIM16","protein_coding","chr17:15627960-15684311:-","gi|48255913|ref|NP_006461.3|",2818,0,"tripartite motif-containing protein 16 [Homo sapiens]","gi|48255912|ref|NM_006470.3|",2782,0,"Homo sapiens tripartite motif containing 16 (TRIM16), mRNA","O95361",1090,0,"Tripartite motif-containing protein 16",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0043966|histone H3 acetylation;GO:0043967|histone H4 acetylation;GO:0050718|positive regulation of interleukin-1 beta secretion;GO:0045618|positive regulation of keratinocyte differentiation;GO:0048386|positive regulation of retinoic acid receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060416|response to growth hormone;GO:0046683|response to organophosphorus;GO:0032526|response to retinoic acid;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016605|PML body;","GO:0003677|DNA binding;GO:0019966|interleukin-1 binding;GO:0032089|NACHT domain binding;GO:0008270|zinc ion binding;","K12006","TRIM16; tripartite motif-containing protein 16"]
["ENSG00000257335",58,52,48,35.1418429758749,6,21,20,4.06143833512166,2.02199074008659,4.28540653119741e-08,2.39169332099929e-07,"up","yes","MGAM","protein_coding","chr7:141907813-142106747:+","gi|578814724|ref|XP_006716231.1|",14136,0,"PREDICTED: maltase-glucoamylase, intestinal isoform X1 [Homo sapiens]","gi|767948981|ref|XM_006716168.2|",9172,0,"PREDICTED: Homo sapiens maltase-glucoamylase (alpha-glucosidase) (MGAM), transcript variant X1, mRNA","O43451",3444,0,"Maltase-glucoamylase, intestinal","SPAPB24D3.10c",399,8e-116,"COG1501","pfam01055","Glyco_hydro_31","Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolizm. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.","GO:0043312|neutrophil degranulation;GO:0044245|polysaccharide digestion;GO:0005983|starch catabolic process;","GO:0016324|apical plasma membrane;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0070821|tertiary granule membrane;","GO:0004558|alpha-1,4-glucosidase activity;GO:0016160|amylase activity;GO:0030246|carbohydrate binding;GO:0003824|catalytic activity;GO:0004339|glucan 1,4-alpha-glucosidase activity;GO:0032450|maltose alpha-glucosidase activity;","K12047","MGAM; maltase-glucoamylase [EC:3.2.1.20 3.2.1.3]"]
["ENSG00000176593",16,17,7,8.81342322823997,2,3,7,4.04638874881917,2.0166349306356,0.00564417349589751,0.015867194051723,"up","yes","AC008969.1","processed_transcript","chr19:58002061-58011232:+","gi|21753866|dbj|BAC04411.1|",1525,0,"unnamed protein product [Homo sapiens]","gi|17386236|gb|AC008969.6|",5326,0,"Homo sapiens chromosome 19 clone CTD-2368P22, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000261114",12,6,9,5.99226149938247,1,4,3,4.04400059123768,2.01578320816467,0.0199074868088462,0.0489764803021717,"up","yes","AC012181.1","sense_intronic","chr16:56941028-56941726:+","gi|119603301|gb|EAW82895.1|",236,2e-22,"hCG2042280, partial [Homo sapiens]","gi|551883059|tpe|HG508133.1|",699,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000432318.1 (RP11-325K4.2 gene), sense_intronic",".",".",".",".",".",".",".",".","pfam11667","DUF3267","Protein of unknown function (DUF3267). This family of proteins has no known function.",".",".",".",".","."]
["ENSG00000128165",770,692,712,488.121795778903,210,198,224,4.04394705446842,2.01576410882454,8.33341878291162e-75,3.78199956434822e-73,"up","yes","ADM2","protein_coding","chr22:50481556-50486440:+","gi|47678489|emb|CAG30365.1|",1183,5e-148,"dJ579N16.4 [Homo sapiens]","gi|359718925|ref|NM_001253845.1|",3996,0,"Homo sapiens adrenomedullin 2 (ADM2), mRNA","Q7Z4H4",244,2e-72,"ADM2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0001525|angiogenesis;GO:0007586|digestion;GO:0007631|feeding behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0045776|negative regulation of blood pressure;GO:0045766|positive regulation of angiogenesis;GO:0010628|positive regulation of gene expression;GO:0006468|protein phosphorylation;","GO:0005576|extracellular region;GO:0005622|intracellular;","GO:0005179|hormone activity;GO:0044877|macromolecular complex binding;",".","."]
["ENSG00000261504",16,9,9,7.52342204858133,2,4,4,4.03991583307689,2.01432523642572,0.00870553253767388,0.0234645488522434,"up","yes","LINC01686","lincRNA","chr1:182615254-182616629:+","gi|724852260|ref|XP_010367266.1|",323,1e-44,"PREDICTED: uncharacterized protein LOC104666826 [Rhinopithecus roxellana]","gi|551898758|tpe|HG492993.1|",1376,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000431576.1 (RP11-317P15.4 gene), lincRNA",".",".",".",".",".",".",".",".","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.",".",".",".",".","."]
["ENSG00000119922",1836,1761,1679,1182.34173408642,392,531,642,4.0247851059878,2.00891175594722,1.116906735092e-207,2.15428971064545e-205,"up","yes","IFIT2","protein_coding","chr10:89283694-89309276:+","gi|34192824|gb|AAH32839.2|",2393,0,"Interferon-induced protein with tetratricopeptide repeats 2 [Homo sapiens]","gi|153082754|ref|NM_001547.4|",3095,0,"Homo sapiens interferon induced protein with tetratricopeptide repeats 2 (IFIT2), mRNA","P09913",907,0,"Interferon-induced protein with tetratricopeptide repeats 2",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0008637|apoptotic mitochondrial changes;GO:0035457|cellular response to interferon-alpha;GO:0051607|defense response to virus;GO:0032091|negative regulation of protein binding;GO:0043065|positive regulation of apoptotic process;GO:0009615|response to virus;GO:0060337|type I interferon signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;","GO:0003723|RNA binding;",".","."]
["ENSG00000258940",13,14,13,8.96747336622649,3,3,6,4.0155440512267,2.00559546640579,0.00402009081817991,0.011658323816126,"up","yes","AL132639.2","antisense","chr14:39265703-39267061:-","gi|119586221|gb|EAW65817.1|",281,2e-27,"hCG2039848 [Homo sapiens]","gi|551878038|tpe|HG506128.1|",1359,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000469934.1 (RP11-407N17.5 gene), antisense",".",".",".",".",".",".",".",".","pfam06797","DUF1229","Protein of unknown function (DUF1229). This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.",".",".",".",".","."]
["ENSG00000229953",50,40,53,32.0659660536208,9,14,20,4.01185327661546,2.00426884399347,1.03594191271131e-07,5.56735793044739e-07,"up","yes","AL590666.2","antisense","chr1:156646507-156661424:-","gi|25989105|gb|AAG01897.1|",619,2e-73,"hyaluronan binding protein [Homo sapiens]","gi|767878331|ref|XR_917739.1|",758,0,"PREDICTED: Homo sapiens uncharacterized LOC105371453 (LOC105371453), ncRNA","Q96GW7",242,5e-72,"Brevican core protein",".",".",".",".","pfam07409","GP46","Phage protein GP46. This family contains GP46 phage proteins (approximately 120 residues long).","GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0030206|chondroitin sulfate biosynthetic process;GO:0030207|chondroitin sulfate catabolic process;GO:0030208|dermatan sulfate biosynthetic process;GO:0030198|extracellular matrix organization;GO:0021766|hippocampus development;GO:0001501|skeletal system development;","GO:0031225|anchored component of membrane;GO:0005576|extracellular region;GO:0005796|Golgi lumen;GO:0043202|lysosomal lumen;","GO:0030246|carbohydrate binding;GO:0005201|extracellular matrix structural constituent;GO:0005540|hyaluronic acid binding;","K06795","BCAN; brevican"]
["ENSG00000261770",29,22,23,16.5997998191981,7,6,9,3.98004500680201,1.99278474502092,0.000105711788843351,0.000401846468902356,"up","yes","AC006504.1","lincRNA","chr19:27757184-27760849:-","gi|221043068|dbj|BAH13211.1|",194,3e-13,"unnamed protein product [Homo sapiens]","gi|666670843|tpe|HG510554.2|",3666,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000431028.2 (CTC-459F4.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam03360","Glyco_transf_43","Glycosyltransferase family 43.",".",".",".",".","."]
["ENSG00000232973",106,103,95,68.4172826664325,23,37,31,3.96023196537529,1.98558493674312,1.23473592027855e-14,1.12284707356589e-13,"up","yes","CYP1B1-AS1","antisense","chr2:38073447-38231651:+","gi|225936138|gb|ACO37435.1|",527,7e-59,"cytochrome P450 [Homo sapiens]","gi|551845077|tpe|HG493869.1|",1644,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000250420.2 (C2orf58 gene), antisense","Q16678",209,4e-57,"Cytochrome P450 1B1",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001525|angiogenesis;GO:0019369|arachidonic acid metabolic process;GO:0048514|blood vessel morphogenesis;GO:0007155|cell adhesion;GO:0006725|cellular aromatic compound metabolic process;GO:0070301|cellular response to hydrogen peroxide;GO:0071407|cellular response to organic cyclic compound;GO:0030199|collagen fibril organization;GO:0043542|endothelial cell migration;GO:0071603|endothelial cell-cell adhesion;GO:0019373|epoxygenase P450 pathway;GO:0008210|estrogen metabolic process;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0046466|membrane lipid catabolic process;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0006809|nitric oxide biosynthetic process;GO:0097267|omega-hydroxylase P450 pathway;GO:0055114|oxidation-reduction process;GO:0045766|positive regulation of angiogenesis;GO:0043065|positive regulation of apoptotic process;GO:0046427|positive regulation of JAK-STAT cascade;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:2000377|regulation of reactive oxygen species metabolic process;GO:0061304|retinal blood vessel morphogenesis;GO:0042574|retinal metabolic process;GO:0042572|retinol metabolic process;GO:0008202|steroid metabolic process;GO:0016125|sterol metabolic process;GO:0009404|toxin metabolic process;GO:0002930|trabecular meshwork development;GO:0007601|visual perception;GO:0006805|xenobiotic metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0031090|organelle membrane;","GO:0070330|aromatase activity;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019825|oxygen binding;","K07410","CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [EC:1.14.14.1]"]
["ENSG00000254226",13,12,10,7.94306722242416,5,4,1,3.95741138463817,1.98455704553001,0.00989507728483645,0.0263068574321055,"up","yes","LINC01933","lincRNA","chr5:151949571-152270448:+","gi|119582058|gb|EAW61654.1|",488,1e-53,"hCG2039000, partial [Homo sapiens]","gi|551857755|tpe|HG498626.1|",3591,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000373979.1 (CTB-12O2.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam10553","MSV199","MSV199 domain. This domain was identified by Iyer and colleagues.",".",".",".",".","."]
["ENSG00000136960",54,44,46,32.4364087918559,15,11,17,3.9505641310989,1.98205868139778,9.64399969299976e-08,5.20608637219646e-07,"up","yes","ENPP2","protein_coding","chr8:119557086-119673453:-","gi|194382080|dbj|BAG58795.1|",1369,2e-174,"unnamed protein product [Homo sapiens]","gi|34530834|dbj|AK124910.1|",3635,0,"Homo sapiens cDNA FLJ42920 fis, clone BRHIP3027854, highly  similar to Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) (ENPP2)","Q13822",528,2e-168,"Ectonucleotide pyrophosphatase/phosphodiesterase family member 2",".",".",".",".","pfam01223","Endonuclease_NS","DNA/RNA non-specific endonuclease.","GO:0048870|cell motility;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0034638|phosphatidylcholine catabolic process;GO:0009395|phospholipid catabolic process;GO:0010634|positive regulation of epithelial cell migration;GO:2000394|positive regulation of lamellipodium morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0045765|regulation of angiogenesis;GO:0030334|regulation of cell migration;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0047391|alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0005509|calcium ion binding;GO:0016787|hydrolase activity;GO:0004622|lysophospholipase activity;GO:0003676|nucleic acid binding;GO:0004551|nucleotide diphosphatase activity;GO:0004528|phosphodiesterase I activity;GO:0030247|polysaccharide binding;GO:0005044|scavenger receptor activity;GO:0008134|transcription factor binding;GO:0008270|zinc ion binding;","K01122","ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [EC:3.1.4.39]"]
["ENSG00000283148",18,10,6,7.53637743832779,3,4,3,3.94084767466178,1.97850598615244,0.0113795285563884,0.0298867574612771,"up","yes","AC137936.1","lincRNA","chr3:58174478-58178374:-","gi|355749856|gb|EHH54194.1|",203,6e-17,"hypothetical protein EGM_14979, partial [Macaca fascicularis]","gi|28014555|gb|AC137936.3|",500,0,"Homo sapiens chromosome 3 clone RP11-456N14, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000227218",27,24,14,14.4225610898972,1,11,8,3.93069648346954,1.97478496750181,0.000846193592798034,0.00280243509922536,"up","yes","AL157935.1","antisense","chr9:127934503-127940952:+",".",".",".",".","gi|767959451|ref|XR_930375.1|",1105,0,"PREDICTED: Homo sapiens uncharacterized LOC105376284 (LOC105376284), ncRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000227400",22,19,18,13.2561899564425,3,9,6,3.90840681043961,1.96658063948095,0.000698916161238026,0.00234732629600541,"up","yes","AC012501.1","sense_overlapping","chr2:153421616-153593288:-","gi|982280131|ref|XP_015286006.1|",234,1e-19,"PREDICTED: protein CASC1 isoform X13 [Macaca fascicularis]","gi|551847345|tpe|HG494766.1|",586,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000332581.1 (AC012501.2 gene), sense_overlapping",".",".",".",".",".",".",".",".","pfam00762","Ferrochelatase","Ferrochelatase.",".",".",".",".","."]
["ENSG00000236562",27,17,30,16.5860247246983,2,5,17,3.88633673446533,1.95841090969736,0.000539802223904208,0.00184571978278042,"up","yes","AC116049.1","processed_pseudogene","chr4:66094142-66094526:+","gi|119625948|gb|EAX05543.1|",670,2e-87,"hCG1746597 [Homo sapiens]","gi|150170720|ref|NG_006204.1|",385,0,"Homo sapiens interferon induced transmembrane protein pseudogene (LOC728048) on chromosome 4","Q01628",243,5e-82,"Interferon-induced transmembrane protein 3",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0051607|defense response to virus;GO:0006955|immune response;GO:0046597|negative regulation of viral entry into host cell;GO:0045071|negative regulation of viral genome replication;GO:0032897|negative regulation of viral transcription;GO:0035455|response to interferon-alpha;GO:0035456|response to interferon-beta;GO:0034341|response to interferon-gamma;GO:0009615|response to virus;GO:0060337|type I interferon signaling pathway;","GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;",".","K06566","IFITM; interferon induced transmembrane protein"]
["ENSG00000164938",231,207,203,144.957453125626,47,86,64,3.85300681808348,1.94598473891896,4.87774843862774e-25,7.19281436423943e-24,"up","yes","TP53INP1","protein_coding","chr8:94925972-94949411:-","gi|15150807|ref|NP_150601.1|",1178,4e-145,"tumor protein p53-inducible nuclear protein 1 isoform a [Homo sapiens]","gi|209180467|ref|NM_033285.3|",5614,0,"Homo sapiens tumor protein p53 inducible nuclear protein 1 (TP53INP1), transcript variant 1, mRNA","Q96A56",458,1e-146,"Tumor protein p53-inducible nuclear protein 1",".",".",".",".","pfam14839","DOR","DOR family. This family of proteins regulate autophagy and gene transcription.","GO:0006915|apoptotic process;GO:0048102|autophagic cell death;GO:0000045|autophagosome assembly;GO:0007050|cell cycle arrest;GO:0071361|cellular response to ethanol;GO:0071447|cellular response to hydroperoxide;GO:0072703|cellular response to methyl methanesulfonate;GO:0034644|cellular response to UV;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0048147|negative regulation of fibroblast proliferation;GO:0010629|negative regulation of gene expression;GO:2001235|positive regulation of apoptotic signaling pathway;GO:0010508|positive regulation of autophagy;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042981|regulation of apoptotic process;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0009408|response to heat;GO:0006351|transcription, DNA-templated;","GO:0005776|autophagosome;GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;","GO:0016209|antioxidant activity;","K15310","TP53INP1; tumor protein p53-inducible nuclear protein 1"]
["ENSG00000232324",54,63,51,37.9355087992291,12,13,28,3.83957362470944,1.94094611207396,2.72122900831088e-08,1.55057799445496e-07,"up","yes","AC008440.3","lincRNA","chr19:53864763-53866140:+","gi|355567321|gb|EHH23662.1|",157,5e-11,"hypothetical protein EGK_07177, partial [Macaca mulatta]","gi|551889983|tpe|HG511011.1|",555,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000313724.1 (AC008440.10 gene), lincRNA","Q96CB5",58.2,8e-10,"Putative uncharacterized protein C8orf44",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".","GO:0005654|nucleoplasm;",".",".","."]
["ENSG00000071242",1847,1678,1676,1179.1844867593,425,536,671,3.80027282449417,1.92610299445515,6.93643039287431e-197,1.23879508720148e-194,"up","yes","RPS6KA2","protein_coding","chr6:166409364-166906451:-","gi|62087812|dbj|BAD92353.1|",4070,0,"ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform b variant [Homo sapiens]","gi|974576788|ref|NM_001318936.1|",5989,0,"Homo sapiens ribosomal protein S6 kinase A2 (RPS6KA2), transcript variant 3, mRNA","Q15349",1423,0,"Ribosomal protein S6 kinase alpha-2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0045786|negative regulation of cell cycle;GO:0008285|negative regulation of cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;","K04373","RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]"]
["ENSG00000257894",22,15,18,12.4792281584279,5,7,5,3.79695796080754,1.92484402580182,0.00115951406738121,0.00374430057452684,"up","yes","AC027288.3","lincRNA","chr12:79341205-79503396:-","gi|106322|pir||B34087",1196,7e-146,"hypothetical protein (L1H 3' region) - human","gi|666687964|tpe|HG505012.2|",1820,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000407119.2 (RP1-78O14.1 gene), lincRNA","O00370",443,3e-139,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam08333","DUF1725","Protein of unknown function (DUF1725). This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["ENSG00000137261",40,36,42,26.8550294856346,10,13,14,3.79516329540131,1.92416196216177,1.6996800998006e-06,8.06678882011664e-06,"up","yes","KIAA0319","protein_coding","chr6:24544104-24646155:-","gi|270265853|ref|NP_001161846.1|",5461,0,"dyslexia-associated protein KIAA0319 isoform b [Homo sapiens]","gi|270265852|ref|NM_001168374.1|",6896,0,"Homo sapiens KIAA0319 (KIAA0319), transcript variant 3, mRNA","Q5VV43",2085,0,"Dyslexia-associated protein KIAA0319","VCA0027_2",54.7,9e-07,"COG3979","pfam02010","REJ","REJ domain. The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.","GO:0061024|membrane organization;GO:2000171|negative regulation of dendrite development;GO:0001764|neuron migration;","GO:0030665|clathrin-coated vesicle membrane;GO:0005769|early endosome;GO:0031901|early endosome membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000250938",12,11,11,7.65886466126071,2,2,7,3.79322054384245,1.92342325464242,0.0112250545100691,0.0295172258200698,"up","yes","AC108866.1","antisense","chr4:120066958-120416766:+",".",".",".",".","gi|551853849|tpe|HG497210.1|",2339,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000364562.1 (RP11-679C8.2 gene), antisense",".",".",".",".",".",".",".",".","pfam09687","PRESAN","Plasmodium RESA N-terminal. The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.",".",".",".",".","."]
["ENSG00000185345",75,60,56,43.2557953315874,22,8,30,3.77535243399025,1.91661132815607,4.74116063561483e-08,2.63765521602939e-07,"up","yes","PRKN","protein_coding","chr6:161347420-162727771:-","gi|469609977|gb|AGH62057.1|",2444,0,"PARK2 splice variant [Homo sapiens]","gi|767942938|ref|XM_011535863.1|",4169,0,"PREDICTED: Homo sapiens parkin RBR E3 ubiquitin protein ligase (PARK2), transcript variant X1, mRNA","O60260",939,0,"E3 ubiquitin-protein ligase parkin","SPAC1805.12c_1",54.7,1e-07,"COG5272","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0008344|adult locomotory behavior;GO:0070842|aggresome assembly;GO:0000422|mitophagy;GO:0044257|cellular protein catabolic process;GO:0044267|cellular protein metabolic process;GO:1903351|cellular response to dopamine;GO:0071287|cellular response to manganese ion;GO:0097237|cellular response to toxic substance;GO:0034620|cellular response to unfolded protein;GO:0007417|central nervous system development;GO:0042417|dopamine metabolic process;GO:0051583|dopamine uptake involved in synaptic transmission;GO:0036503|ERAD pathway;GO:0010994|free ubiquitin chain polymerization;GO:0007612|learning;GO:0016236|macroautophagy;GO:0000266|mitochondrial fission;GO:0007005|mitochondrion organization;GO:0000423|macromitophagy;GO:0044828|negative regulation by host of viral genome replication;GO:0032232|negative regulation of actin filament bundle assembly;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0060548|negative regulation of cell death;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903382|negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903542|negative regulation of exosomal secretion;GO:0010629|negative regulation of gene expression;GO:0033132|negative regulation of glucokinase activity;GO:0046676|negative regulation of insulin secretion;GO:1902254|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0046329|negative regulation of JNK cascade;GO:0010637|negative regulation of mitochondrial fusion;GO:0043524|negative regulation of neuron apoptotic process;GO:1901215|negative regulation of neuron death;GO:1903202|negative regulation of oxidative stress-induced cell death;GO:1903377|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1902283|negative regulation of primary amine oxidase activity;GO:0001933|negative regulation of protein phosphorylation;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:1904049|negative regulation of spontaneous neurotransmitter secretion;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0070050|neuron cellular homeostasis;GO:0042415|norepinephrine metabolic process;GO:0061734|parkin-mediated mitophagy in response to mitochondrial depolarization;GO:1903599|positive regulation of mitophagy;GO:1903861|positive regulation of dendrite extension;GO:0043388|positive regulation of DNA binding;GO:0010628|positive regulation of gene expression;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0090141|positive regulation of mitochondrial fission;GO:0010636|positive regulation of mitochondrial fusion;GO:0098779|mitophagy in response to mitochondrial depolarization;GO:0051582|positive regulation of neurotransmitter uptake;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032092|positive regulation of protein binding;GO:0045732|positive regulation of protein catabolic process;GO:1902530|positive regulation of protein linear polyubiquitination;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0010498|proteasomal protein catabolic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865|protein autoubiquitination;GO:0031648|protein destabilization;GO:0016579|protein deubiquitination;GO:0070979|protein K11-linked ubiquitination;GO:0044314|protein K27-linked ubiquitination;GO:0035519|protein K29-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0085020|protein K6-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0070585|protein localization to mitochondrion;GO:0006513|protein monoubiquitination;GO:0000209|protein polyubiquitination;GO:0050821|protein stabilization;GO:0016567|protein ubiquitination;GO:0010506|regulation of autophagy;GO:0060828|regulation of canonical Wnt signaling pathway;GO:1900407|regulation of cellular response to oxidative stress;GO:0042053|regulation of dopamine metabolic process;GO:0014059|regulation of dopamine secretion;GO:0010906|regulation of glucose metabolic process;GO:0032368|regulation of lipid transport;GO:0051881|regulation of mitochondrial membrane potential;GO:0010821|regulation of mitochondrion organization;GO:0031647|regulation of protein stability;GO:1903214|regulation of protein targeting to mitochondrion;GO:0031396|regulation of protein ubiquitination;GO:2000377|regulation of reactive oxygen species metabolic process;GO:1902803|regulation of synaptic vesicle transport;GO:0034976|response to endoplasmic reticulum stress;GO:0006979|response to oxidative stress;GO:0001964|startle response;GO:0035249|synaptic transmission, glutamatergic;GO:0006351|transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0055069|zinc ion homeostasis;","GO:0016235|aggresome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0097413|Lewy body;GO:0005739|mitochondrion;GO:0043005|neuron projection;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:1990452|Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0048471|perinuclear region of cytoplasm;GO:0098793|presynapse;GO:0000151|ubiquitin ligase complex;","GO:0003779|actin binding;GO:0008013|beta-catenin binding;GO:0051087|chaperone binding;GO:0097602|cullin family protein binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019899|enzyme binding;GO:1990444|F-box domain binding;GO:0001664|G-protein coupled receptor binding;GO:0031072|heat shock protein binding;GO:0042826|histone deacetylase binding;GO:0030544|Hsp70 protein binding;GO:0042802|identical protein binding;GO:0019900|kinase binding;GO:0030165|PDZ domain binding;GO:0043274|phospholipase binding;GO:0019901|protein kinase binding;GO:0017124|SH3 domain binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0015631|tubulin binding;GO:0043130|ubiquitin binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;GO:1990381|ubiquitin-specific protease binding;GO:0008270|zinc ion binding;","K04556","PARK2; parkin [EC:2.3.2.27]"]
["ENSG00000139211",7808,7275,7269,5079.60892282062,1937,2232,2882,3.77486995780487,1.91642694524261,0,0,"up","yes","AMIGO2","protein_coding","chr12:47075707-47079951:-","gi|32469517|ref|NP_862830.1|",2655,0,"amphoterin-induced protein 2 precursor [Homo sapiens]","gi|219521829|ref|NM_181847.4|",3763,0,"Homo sapiens adhesion molecule with Ig-like domain 2 (AMIGO2), transcript variant 2, mRNA","Q86SJ2",986,0,"Amphoterin-induced protein 2","SPy1798",53.5,5e-06,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0043066|negative regulation of apoptotic process;GO:0043069|negative regulation of programmed cell death;","GO:0016021|integral component of membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000172382",53,56,51,36.538549137992,18,14,18,3.76618294410095,1.91310308124178,4.27165523030547e-08,2.38470871438877e-07,"up","yes","PRSS27","protein_coding","chr16:2712418-2720551:-","gi|34533017|dbj|BAC86575.1|",702,1e-81,"unnamed protein product [Homo sapiens]","gi|40018660|gb|AC092117.4|",3579,0,"Homo sapiens chromosome 16 clone CTD-2270P14, complete sequence","Q9BQR3",116,2e-26,"Serine protease 27","VC1649",55.8,5e-07,"COG5640","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0046658|anchored component of plasma membrane;GO:0005576|extracellular region;GO:0019897|extrinsic component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K09628","PRSS27; protease, serine 27 [EC:3.4.21.-]"]
["ENSG00000162894",32,44,39,26.2205838435886,7,14,16,3.7563380978687,1.90932692192841,4.28570151468956e-06,1.95143085022031e-05,"up","yes","FCMR","protein_coding","chr1:206904386-206923247:-","gi|4885641|ref|NP_005440.1|",1520,0,"fas apoptotic inhibitory molecule 3 isoform a precursor [Homo sapiens]","gi|216547545|ref|NM_005449.4|",1950,0,"Homo sapiens Fc fragment of IgM receptor (FCMR), transcript variant 1, mRNA","O60667",590,0,"Fas apoptotic inhibitory molecule 3",".",".",".",".","pfam15093","DUF4555","Domain of unknown function (DUF4555). This family of proteins is functionally uncharacterized. This family of proteins is found in metazoa.This family includes the human protein C7orf31.","GO:0006968|cellular defense response;GO:0002376|immune system process;GO:0043066|negative regulation of apoptotic process;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000070669",190,181,166,122.422369248104,55,58,55,3.7541105654404,1.90847114080906,1.71527710565984e-22,2.27853063457073e-21,"up","yes","ASNS","protein_coding","chr7:97852118-97872542:-","gi|168229248|ref|NP_597680.2|",2854,0,"asparagine synthetase [glutamine-hydrolyzing] isoform a [Homo sapiens]","gi|296010845|ref|NM_183356.3|",2356,0,"Homo sapiens asparagine synthetase (glutamine-hydrolyzing) (ASNS), transcript variant 3, mRNA","P08243",1100,0,"Asparagine synthetase [glutamine-hydrolyzing]","L00396",326,2e-100,"COG0367","pfam00733","Asn_synthase","Asparagine synthase. This family is always found associated with pfam00310. Members of this family catalyse the conversion of aspartate to asparagine.","GO:0006529|asparagine biosynthetic process;GO:0008652|cellular amino acid biosynthetic process;GO:0042149|cellular response to glucose starvation;GO:0032870|cellular response to hormone stimulus;GO:0006541|glutamine metabolic process;GO:0070981|L-asparagine biosynthetic process;GO:0001889|liver development;GO:0043066|negative regulation of apoptotic process;GO:0036499|PERK-mediated unfolded protein response;GO:0045931|positive regulation of mitotic cell cycle;GO:0043200|response to amino acid;GO:0032354|response to follicle-stimulating hormone;GO:0009416|response to light stimulus;GO:0009612|response to mechanical stimulus;GO:0031427|response to methotrexate;GO:0009636|response to toxic substance;","GO:0005829|cytosol;","GO:0004066|asparagine synthase (glutamine-hydrolyzing) activity;GO:0005524|ATP binding;GO:0048037|cofactor binding;GO:0042803|protein homodimerization activity;","K01953","asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]"]
["ENSG00000229644",2548,2412,2326,1659.10257702227,664,748,895,3.74593915990877,1.90532746807784,1.25894372248499e-241,2.99784031102351e-239,"up","yes","NAMPTP1","processed_pseudogene","chr10:36521721-36524234:-","gi|163930869|pdb|2E5B|A",2396,0,"Chain A, Crystal Structure Of Human Nmprtase As Free-Form","gi|693582870|ref|NG_005593.6|",2514,0,"Homo sapiens nicotinamide phosphoribosyltransferase pseudogene 1 (NAMPTP1) on chromosome 10","P43490",924,0,"Nicotinamide phosphoribosyltransferase","RSp0836",375,4e-119,"COG1488","pfam04095","NAPRTase","Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine. This family is related to Quinolinate phosphoribosyltransferase pfam01729.","GO:0007267|cell-cell signaling;GO:0032922|circadian regulation of gene expression;GO:0007623|circadian rhythm;GO:0007565|female pregnancy;GO:0034356|NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0008284|positive regulation of cell proliferation;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0014070|response to organic cyclic compound;GO:0007165|signal transduction;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016607|nuclear speck;","GO:0005125|cytokine activity;GO:0008144|drug binding;GO:0042802|identical protein binding;GO:0047280|nicotinamide phosphoribosyltransferase activity;GO:0004514|nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0042803|protein homodimerization activity;","K03462","NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]"]
["ENSG00000203855",21,14,3,8.41011839599281,2,5,5,3.74299984635939,1.90419498901892,0.0147267561055826,0.0376207652943906,"up","yes","HSD3BP4","unprocessed_pseudogene","chr1:119564066-119572067:+","gi|19979635|gb|AAM08704.1|",1371,0,"3-beta-hydroxysteroid dehydrogenase [Homo sapiens]","gi|795072279|ref|XM_011982252.1|",863,0,"PREDICTED: Mandrillus leucophaeus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2), transcript variant X2, mRNA","P27365",506,0,"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","YGL001c",87.8,1e-18,"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.","GO:0006694|steroid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0003854|3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0004769|steroid delta-isomerase activity;",".","."]
["ENSG00000105835",24511,22112,21960,15612.4079037125,5951,7237,8648,3.73108842467218,1.89959655161124,0,0,"up","yes","NAMPT","protein_coding","chr7:106248285-106286326:-","gi|5031977|ref|NP_005737.1|",2510,0,"nicotinamide phosphoribosyltransferase precursor [Homo sapiens]","gi|111161293|ref|NM_005746.2|",4582,0,"Homo sapiens nicotinamide phosphoribosyltransferase (NAMPT), mRNA","P43490",969,0,"Nicotinamide phosphoribosyltransferase","RSp0836",390,4e-120,"COG1488","pfam04095","NAPRTase","Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine. This family is related to Quinolinate phosphoribosyltransferase pfam01729.","GO:0007267|cell-cell signaling;GO:0032922|circadian regulation of gene expression;GO:0007623|circadian rhythm;GO:0007565|female pregnancy;GO:0034356|NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0008284|positive regulation of cell proliferation;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0014070|response to organic cyclic compound;GO:0007165|signal transduction;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016607|nuclear speck;","GO:0005125|cytokine activity;GO:0008144|drug binding;GO:0042802|identical protein binding;GO:0047280|nicotinamide phosphoribosyltransferase activity;GO:0004514|nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0042803|protein homodimerization activity;","K03462","NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]"]
["ENSG00000250033",169,113,116,90.0939192798821,28,53,46,3.71625780022606,1.89385058627571,1.48198514902507e-15,1.40949356777098e-14,"up","yes","SLC7A11-AS1","processed_transcript","chr4:138057464-138178177:+","gi|119625542|gb|EAX05137.1|",527,5e-58,"hCG1647865 [Homo sapiens]","gi|335353790|ref|NR_038380.1|",4654,0,"Homo sapiens SLC7A11 antisense RNA 1 (SLC7A11-AS1), long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000150051",272,242,220,167.060352839054,55,95,86,3.69591872934692,1.88593303325363,6.76541502784177e-29,1.1527502213517e-27,"up","yes","MKX","protein_coding","chr10:27672875-27746060:-","gi|178057337|ref|NP_775847.2|",1818,0,"homeobox protein Mohawk [Homo sapiens]","gi|694939146|ref|XM_001160740.4|",3753,0,"PREDICTED: Pan troglodytes mohawk homeobox (MKX), transcript variant X1, mRNA","Q8IYA7",704,0,"Homeobox protein Mohawk",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0007517|muscle organ development;","GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["ENSG00000166741",17,23,18,13.4095591728786,9,5,4,3.69549522310541,1.88576770890324,0.00143271699861109,0.00455259398174807,"up","yes","NNMT","protein_coding","chr11:114257787-114313285:+","gi|5453790|ref|NP_006160.1|",1401,0,"nicotinamide N-methyltransferase [Homo sapiens]","gi|426370514|ref|XM_004052160.1|",1804,0,"PREDICTED: Gorilla gorilla gorilla nicotinamide N-methyltransferase, transcript variant 2 (NNMT), mRNA","P40261",544,0,"Nicotinamide N-methyltransferase",".",".",".",".","pfam01234","NNMT_PNMT_TEMT","NNMT/PNMT/TEMT family.","GO:0031100|organ regeneration;GO:0032259|methylation;GO:0034356|NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0042493|response to drug;GO:0010243|response to organonitrogen compound;","GO:0005829|cytosol;","GO:0008112|nicotinamide N-methyltransferase activity;GO:0030760|pyridine N-methyltransferase activity;","K00541","NNMT; nicotinamide N-methyltransferase [EC:2.1.1.1]"]
["ENSG00000124882",12460,11117,11111,7917.43453619872,3039,3717,4435,3.68338016715372,1.88103030762659,0,0,"up","yes","EREG","protein_coding","chr4:74365143-74388751:+","gi|4557567|ref|NP_001423.1|",752,3e-88,"proepiregulin preproprotein [Homo sapiens]","gi|119703747|ref|NM_001432.2|",4619,0,"Homo sapiens epiregulin (EREG), mRNA","O14944",294,1e-89,"Proepiregulin",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0009653|anatomical structure morphogenesis;GO:0001525|angiogenesis;GO:0009887|organ morphogenesis;GO:0007267|cell-cell signaling;GO:0019221|cytokine-mediated signaling pathway;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0038128|ERBB2 signaling pathway;GO:0007143|female meiotic division;GO:0030216|keratinocyte differentiation;GO:0043616|keratinocyte proliferation;GO:0042700|luteinizing hormone signaling pathway;GO:0000165|MAPK cascade;GO:0009299|mRNA transcription;GO:0008285|negative regulation of cell proliferation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051151|negative regulation of smooth muscle cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0001556|oocyte maturation;GO:0001550|ovarian cumulus expansion;GO:0030728|ovulation;GO:0051781|positive regulation of cell division;GO:0008284|positive regulation of cell proliferation;GO:0042108|positive regulation of cytokine biosynthetic process;GO:0001819|positive regulation of cytokine production;GO:0045740|positive regulation of DNA replication;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0048146|positive regulation of fibroblast proliferation;GO:0045089|positive regulation of innate immune response;GO:0045410|positive regulation of interleukin-6 biosynthetic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0042327|positive regulation of phosphorylation;GO:0045860|positive regulation of protein kinase activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048160|primary follicle stage;GO:2000145|regulation of cell motility;GO:0043434|response to peptide hormone;GO:0042060|wound healing;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K09784","EREG; epiregulin"]
["ENSG00000116761",656,542,640,420.548686748001,158,196,245,3.66037395885953,1.87199104769839,7.52020682432955e-64,2.77873082811625e-62,"up","yes","CTH","protein_coding","chr1:70411218-70439851:+","gi|299473759|ref|NP_001177392.1|",1940,0,"cystathionine gamma-lyase isoform 3 [Homo sapiens]","gi|299473758|ref|NM_001190463.1|",2044,0,"Homo sapiens cystathionine gamma-lyase (CTH), transcript variant 3, mRNA","P32929",736,0,"Cystathionine gamma-lyase","APE1226",343,6e-110,"COG0626","pfam01053","Cys_Met_Meta_PP","Cys/Met metabolizm PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolizm. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.","GO:0071266|'de novo' L-methionine biosynthetic process;GO:1990830|cellular response to leukemia inhibitory factor;GO:0019344|cysteine biosynthetic process;GO:0019343|cysteine biosynthetic process via cystathionine;GO:0006534|cysteine metabolic process;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0070814|hydrogen sulfide biosynthetic process;GO:2001234|negative regulation of apoptotic signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051289|protein homotetramerization;GO:0044524|protein sulfhydration;GO:0018272|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine;GO:0000098|sulfur amino acid catabolic process;GO:0019346|transsulfuration;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0005516|calmodulin binding;GO:0016846|carbon-sulfur lyase activity;GO:0004123|cystathionine gamma-lyase activity;GO:0003962|cystathionine gamma-synthase activity;GO:0047982|homocysteine desulfhydrase activity;GO:0042802|identical protein binding;GO:0080146|L-cysteine desulfhydrase activity;GO:0044540|L-cystine L-cysteine-lyase (deaminating);GO:0030170|pyridoxal phosphate binding;","K01758","CTH; cystathionine gamma-lyase [EC:4.4.1.1]"]
["ENSG00000160602",255,263,246,174.715022624304,60,85,105,3.65812847720788,1.87110574489957,9.57828354911398e-32,1.80064262276131e-30,"up","yes","NEK8","protein_coding","chr17:28725897-28743455:+","gi|635088784|ref|XP_008009021.1|",3416,0,"PREDICTED: serine/threonine-protein kinase Nek8 isoform X1 [Chlorocebus sabaeus]","gi|31342341|ref|NM_178170.2|",2858,0,"Homo sapiens NIMA related kinase 8 (NEK8), mRNA","Q86SG6",1317,0,"Serine/threonine-protein kinase Nek8",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0009887|organ morphogenesis;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0035330|regulation of hippo signaling;","GO:0097546|ciliary base;GO:0097543|ciliary inversin compartment;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;",".","."]
["ENSG00000167355",16,12,17,10.2722370752405,3,4,8,3.64625464387783,1.86641531854416,0.00407188382642406,0.0117854884820029,"up","yes","OR51B5","protein_coding","chr11:5303444-5505652:-",".",".",".",".","gi|28191474|gb|AC104389.8|",1040,0,"Homo sapiens chromosome 11, clone CTD-2643I7, complete sequence",".",".",".",".",".",".",".",".","pfam12470","SUFU_C","Suppressor of Fused Gli/Ci N terminal binding domain. This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologues. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologues.",".",".",".",".","."]
["ENSG00000135063",75,85,69,52.3403159492394,20,16,40,3.63720832353991,1.86283155948359,7.66865442261926e-10,5.02934398175723e-09,"up","yes","FAM189A2","protein_coding","chr9:69324567-69392558:+","gi|16551477|dbj|BAB71105.1|",1018,3e-123,"unnamed protein product [Homo sapiens]","gi|15022185|emb|AL355140.25|",3947,0,"Human DNA sequence from clone RP11-548B3 on chromosome 9, complete sequence","Q15884",399,3e-123,"Protein FAM189A2",".",".",".",".","pfam10667","DUF2486","Protein of unknown function (DUF2486). This family is made up of members from various Burkholderia spp. The function is unknown.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000260920",172,178,145,113.274140477697,42,58,62,3.63164477371389,1.86062309352514,5.02211642198978e-21,6.26562623204003e-20,"up","yes","AL031985.3","sense_overlapping","chr1:40464319-40466767:+",".",".",".",".","gi|666688014|tpe|HG491937.2|",2449,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000431151.2 (RP1-228H13.5 gene), sense_overlapping",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000154165",107,63,76,55.9783012462031,19,28,34,3.61762195013094,1.85504165086445,1.81691822241279e-10,1.25718444857186e-09,"up","yes","GPR15","protein_coding","chr3:98531899-98533150:+","gi|4885299|ref|NP_005281.1|",1790,0,"G-protein coupled receptor 15 [Homo sapiens]","gi|410651496|ref|NM_005290.2|",1252,0,"Homo sapiens G protein-coupled receptor 15 (GPR15), mRNA","Q9BG77",694,0,"G-protein coupled receptor 15",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0072678|T cell migration;","GO:0005768|endosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0015026|coreceptor activity;GO:0004930|G-protein coupled receptor activity;GO:0001618|virus receptor activity;","K08403","GPR15; G protein-coupled receptor 15"]
["ENSG00000159650",10,9,13,7.33111648300422,1,4,6,3.59177734990059,1.84469792186359,0.0171235898721245,0.0429716109099061,"up","yes","UROC1","protein_coding","chr3:126481281-126517773:-","gi|21389467|ref|NP_653240.1|",3473,0,"urocanate hydratase isoform 1 [Homo sapiens]","gi|260305963|ref|NM_144639.2|",3149,0,"Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA","Q96N76",1342,0,"Urocanate hydratase","SPy2082",545,1e-179,"COG2987","pfam01175","Urocanase","Urocanase.","GO:0006548|histidine catabolic process;GO:0019556|histidine catabolic process to glutamate and formamide;GO:0019557|histidine catabolic process to glutamate and formate;","GO:0005829|cytosol;","GO:0016153|urocanate hydratase activity;","K01712","hutU, UROC1; urocanate hydratase [EC:4.2.1.49]"]
["ENSG00000262001",127,140,128,90.9954455934702,40,37,54,3.58621563666096,1.84246223906746,9.75820701805113e-17,9.89570436194375e-16,"up","yes","DLGAP1-AS2","antisense","chr18:3603000-3608336:+","gi|119622068|gb|EAX01663.1|",463,2e-51,"hCG2042951 [Homo sapiens]","gi|551886758|tpe|HG509669.1|",2261,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000439287.1 (RP11-874J12.1 gene), antisense","Q86U02",90.9,1e-19,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000125826",12064,11134,10466,7723.20037126709,2956,3661,4565,3.58602569954676,1.84238582743546,0,0,"up","yes","RBCK1","protein_coding","chr20:407498-430966:+","gi|795452377|ref|XP_011764559.1|",2350,0,"PREDICTED: LOW QUALITY PROTEIN: ranBP-type and C3HC4-type zinc finger-containing protein 1 [Macaca nemestrina]","gi|144953897|ref|NM_031229.2|",2762,0,"Homo sapiens RANBP2-type and C3HC4-type zinc finger containing 1 (RBCK1), transcript variant 2, mRNA","Q9BYM8",902,0,"RanBP-type and C3HC4-type zinc finger-containing protein 1",".",".",".",".","pfam01485","IBR","IBR domain. The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0060546|negative regulation of necroptotic process;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0097039|protein linear polyubiquitination;GO:0000209|protein polyubiquitination;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0050852|T cell receptor signaling pathway;GO:0016032|viral process;","GO:0005829|cytosol;GO:0071797|LUBAC complex;","GO:0046872|metal ion binding;GO:0043130|ubiquitin binding;GO:0004842|ubiquitin-protein transferase activity;","K10630","RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.27]"]
["ENSG00000262089",9,16,10,8.01322776827992,1,5,6,3.58560237345682,1.8422155089401,0.0139317971706688,0.0358731479425576,"up","yes","AC040977.1","lincRNA","chr17:6994642-6995189:-",".",".",".",".","gi|551884382|tpe|HG508624.1|",343,2e-178,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000439617.1 (RP11-589P10.5 gene), lincRNA",".",".",".",".",".",".",".",".","pfam12048","DUF3530","Protein of unknown function (DUF3530). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 272 to 336 amino acids in length. These proteins are distantly related to alpa/beta hydrolases so they may act as enzymes.",".",".",".",".","."]
["ENSG00000100889",3856,3717,3393,2517.43199303199,983,1192,1464,3.58540388589742,1.84213564371412,0,0,"up","yes","PCK2","protein_coding","chr14:24094053-24110598:+","gi|635126049|ref|XP_007984462.1|",3479,0,"PREDICTED: phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [Chlorocebus sabaeus]","gi|808688354|ref|NM_001308054.1|",2505,0,"Homo sapiens phosphoenolpyruvate carboxykinase 2, mitochondrial (PCK2), transcript variant 4, mRNA","Q16822",1244,0,"Phosphoenolpyruvate carboxykinase [GTP], mitochondrial","CPn0851",630,0,"COG1274","pfam00821","PEPCK","Phosphoenolpyruvate carboxykinase. Catalyses the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate.","GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0006094|gluconeogenesis;GO:0006116|NADH oxidation;GO:0006107|oxaloacetate metabolic process;GO:0032024|positive regulation of insulin secretion;GO:0006090|pyruvate metabolic process;GO:0071548|response to dexamethasone;GO:0032496|response to lipopolysaccharide;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0005525|GTP binding;GO:0046872|metal ion binding;GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity;GO:0004611|phosphoenolpyruvate carboxykinase activity;","K01596","E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]"]
["ENSG00000183444",13,10,7,6.81865121894101,2,4,4,3.56883744951293,1.83545419219048,0.0200748417055763,0.0493252925881726,"up","yes","OR7E38P","unprocessed_pseudogene","chr7:97966090-97967074:-","gi|931578598|ref|XP_008969718.2|",631,9e-125,"PREDICTED: LOW QUALITY PROTEIN: olfactory receptor 7E24-like [Pan paniscus]","gi|198041628|ref|NG_002209.3|",985,0,"Homo sapiens olfactory receptor family 7 subfamily E member 38 pseudogene (OR7E38P) on chromosome 7","Q6IFN5",192,2e-98,"Olfactory receptor 7E24",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0050911|detection of chemical stimulus involved in sensory perception of smell;GO:0007186|G-protein coupled receptor signaling pathway;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSG00000162814",17,16,18,11.7966199415079,6,4,7,3.55372222788272,1.82933091937521,0.00236864090843878,0.00722427986115864,"up","yes","SPATA17","protein_coding","chr1:217631324-217871696:+","gi|20270345|ref|NP_620151.1|",1766,0,"spermatogenesis-associated protein 17 [Homo sapiens]","gi|16973876|emb|AL445428.5|",4677,0,"Human DNA sequence from clone RP11-144C20 on chromosome 1, complete sequence","Q96L03",684,0,"Spermatogenesis-associated protein 17",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005737|cytoplasm;","GO:0005516|calmodulin binding;",".","."]
["ENSG00000163393",760,679,604,469.636738499492,187,245,250,3.54371773989951,1.82526369659488,1.73290584023906e-70,7.26614953185456e-69,"up","yes","SLC22A15","protein_coding","chr1:115976498-116070054:+","gi|635105520|ref|XP_007975635.1|",2668,0,"PREDICTED: solute carrier family 22 member 15 isoform X1 [Chlorocebus sabaeus]","gi|166197672|ref|NM_018420.2|",4720,0,"Homo sapiens solute carrier family 22 member 15 (SLC22A15), mRNA","Q8IZD6",977,0,"Solute carrier family 22 member 15",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.",".","GO:0016021|integral component of membrane;","GO:0008514|organic anion transmembrane transporter activity;","K08211","SLC22A15; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 15"]
["ENSG00000131096",18,13,7,8.60690327229853,2,5,6,3.50236573353987,1.80832974465493,0.0117346600193129,0.0307566411812077,"up","yes","PYY","protein_coding","chr17:43952738-44004469:-","gi|119572031|gb|EAW51646.1|",623,1e-76,"peptide YY, isoform CRA_c, partial [Homo sapiens]","gi|998614202|ref|NM_004160.5|",1050,0,"Homo sapiens peptide YY (PYY), mRNA","P10082",158,5e-46,"Peptide YY",".",".",".",".","pfam00159","Hormone_3","Pancreatic hormone peptide.","GO:0008283|cell proliferation;GO:0007631|feeding behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0032098|regulation of appetite;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0001664|G-protein coupled receptor binding;GO:0005179|hormone activity;GO:0005184|neuropeptide hormone activity;","K05233","PYY; peptide YY"]
["ENSG00000273129",22,26,17,14.8718880616662,3,6,14,3.48174656838703,1.79981119499431,0.00115255782058108,0.00372620436529801,"up","yes","PACERR","lincRNA","chr1:186680622-186681446:+","gi|90078737|dbj|BAE89048.1|",199,6e-17,"unnamed protein product [Macaca fascicularis]","gi|654825055|ref|NG_028206.2|",825,0,"Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2), RefSeqGene on chromosome 1",".",".",".",".",".",".",".",".","pfam03092","BT1","BT1 family. Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).",".",".",".",".","."]
["ENSG00000205426",12786,15799,14628,10045.3829508268,4248,4441,6192,3.46763726211189,1.79395299096957,1.8003281827009e-36,3.78677535310087e-35,"up","yes","KRT81","protein_coding","chr12:52285913-52291534:-","gi|169790853|ref|NP_002272.2|",2342,0,"keratin, type II cuticular Hb1 [Homo sapiens]","gi|767974217|ref|XM_011538334.1|",1929,0,"PREDICTED: Homo sapiens keratin 81, type II (KRT81), transcript variant X1, mRNA","Q14533",907,0,"Keratin, type II cuticular Hb1",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0070268|cornification;GO:0031424|keratinization;","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0045095|keratin filament;","GO:0005198|structural molecule activity;","K07605","KRT2; type II keratin, basic"]
["ENSG00000181585",24,23,11,13.2533582920012,5,5,10,3.46579189807602,1.7931850311204,0.00205799607758625,0.00635928041404735,"up","yes","TMIE","protein_coding","chr3:46694528-46710886:+","gi|694901430|ref|XP_009443631.1|",443,2e-57,"PREDICTED: transmembrane inner ear expressed protein isoform X2 [Pan troglodytes]","gi|158631210|ref|NM_147196.2|",1824,0,"Homo sapiens transmembrane inner ear (TMIE), mRNA","Q8NEW7",182,2e-52,"Transmembrane inner ear expressed protein",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000178773",21,15,13,11.3648625738652,7,7,2,3.46474145497367,1.79274769996884,0.00535338051971649,0.0151313017972291,"up","yes","CPNE7","protein_coding","chr16:89575768-89597246:+","gi|7656993|ref|NP_055242.1|",3239,0,"copine-7 isoform b [Homo sapiens]","gi|214830496|ref|NM_014427.4|",2657,0,"Homo sapiens copine 7 (CPNE7), transcript variant 2, mRNA","Q9UBL6",1252,0,"Copine-7",".",".",".",".","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.","GO:0071277|cellular response to calcium ion;GO:0046474|glycerophospholipid biosynthetic process;GO:0006629|lipid metabolic process;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005215|transporter activity;",".","."]
["ENSG00000223878",10,13,9,7.43220756868968,4,2,5,3.45097341599835,1.78700336025414,0.018452400370375,0.0458292426402001,"up","yes","PPIAP53","processed_pseudogene","chr17:15506866-15507354:+","gi|795243476|ref|XP_011913361.1|",357,9e-68,"PREDICTED: CMRF35-like molecule 9 isoform X1 [Cercocebus atys]","gi|666335658|ref|NG_030098.2|",489,0,"Homo sapiens peptidylprolyl isomerase A (cyclophilin A) pseudogene (LOC649873) on chromosome 17","P62936",140,3e-68,"Peptidyl-prolyl cis-trans isomerase A","SPBC28F2.03",102,8e-45,"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.","GO:0006457|protein folding;GO:0000413|protein peptidyl-prolyl isomerization;GO:0045069|regulation of viral genome replication;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0005634|nucleus;","GO:0016018|cyclosporin A binding;GO:0003755|peptidyl-prolyl cis-trans isomerase activity;","K03767","PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]"]
["ENSG00000073150",448,460,482,323.314389050663,118,168,201,3.42027479952359,1.77411224206532,3.39835542076378e-47,9.29751480222578e-46,"up","yes","PANX2","protein_coding","chr22:50170731-50180294:+","gi|163659920|ref|NP_443071.2|",2833,0,"pannexin-2 isoform 1 [Homo sapiens]","gi|163659919|ref|NM_052839.3|",3051,0,"Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA","Q96RD6",1095,0,"Pannexin-2",".",".",".",".","pfam00876","Innexin","Innexin. This family includes the drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.","GO:0006812|cation transport;GO:0007267|cell-cell signaling;GO:0034214|protein hexamerization;GO:0002931|response to ischemia;","GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0005921|gap junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0055077|gap junction hemi-channel activity;GO:0022829|wide pore channel activity;",".","."]
["ENSG00000179477",19,21,15,12.8031988898181,6,7,6,3.39856188727782,1.76492439430386,0.00214023085188273,0.00657546554175122,"up","yes","ALOX12B","protein_coding","chr17:8072636-8087716:-","gi|4502053|ref|NP_001130.1|",3690,0,"arachidonate 12-lipoxygenase, 12R-type [Homo sapiens]","gi|119964724|ref|NM_001139.2|",2502,0,"Homo sapiens arachidonate 12-lipoxygenase, 12R type (ALOX12B), mRNA","O75342",1425,0,"Arachidonate 12-lipoxygenase, 12R-type",".",".",".",".","pfam00305","Lipoxygenase","Lipoxygenase.","GO:0019369|arachidonic acid metabolic process;GO:0046513|ceramide biosynthetic process;GO:0061436|establishment of skin barrier;GO:0051122|hepoxilin biosynthetic process;GO:0043651|linoleic acid metabolic process;GO:0019372|lipoxygenase pathway;GO:0055114|oxidation-reduction process;GO:0010628|positive regulation of gene expression;GO:0043410|positive regulation of MAPK cascade;GO:0070257|positive regulation of mucus secretion;GO:0006497|protein lipidation;GO:0006665|sphingolipid metabolic process;","GO:0005829|cytosol;","GO:0004052|arachidonate 12-lipoxygenase activity;GO:0005506|iron ion binding;GO:1990136|linoleate 9S-lipoxygenase activity;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;","K08021","ALOX12B; arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-]"]
["ENSG00000124762",3194,3287,3012,2210.2500625449,940,1030,1364,3.38876117159735,1.76075796414754,1.95312170012245e-221,4.18575681688465e-219,"up","yes","CDKN1A","protein_coding","chr6:36676460-36687339:+","gi|62089348|dbj|BAD93118.1|",795,2e-97,"Cyclin-dependent kinase variant [Homo sapiens]","gi|334085241|ref|NM_001220778.1|",2264,0,"Homo sapiens cyclin-dependent kinase inhibitor 1A (CDKN1A), transcript variant 4, mRNA","P38936",296,4e-94,"Cyclin-dependent kinase inhibitor 1",".",".",".",".","pfam02234","CDI","Cyclin-dependent kinase inhibitor. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.","GO:0031100|organ regeneration;GO:0007050|cell cycle arrest;GO:0034198|cellular response to amino acid starvation;GO:0006974|cellular response to DNA damage stimulus;GO:0031668|cellular response to extracellular stimulus;GO:0071480|cellular response to gamma radiation;GO:0034605|cellular response to heat;GO:0071479|cellular response to ionizing radiation;GO:0071493|cellular response to UV-B;GO:0090398|cellular senescence;GO:0019221|cytokine-mediated signaling pathway;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0060574|intestinal epithelial cell maturation;GO:0097193|intrinsic apoptotic signaling pathway;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0071850|mitotic cell cycle arrest;GO:0043066|negative regulation of apoptotic process;GO:0030308|negative regulation of cell growth;GO:0008285|negative regulation of cell proliferation;GO:1904030|negative regulation of cyclin-dependent protein kinase activity;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:0010629|negative regulation of gene expression;GO:0042326|negative regulation of phosphorylation;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:0030890|positive regulation of B cell proliferation;GO:0048146|positive regulation of fibroblast proliferation;GO:0043068|positive regulation of programmed cell death;GO:0045860|positive regulation of protein kinase activity;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:0050821|protein stabilization;GO:0007265|Ras protein signal transduction;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000278|regulation of DNA biosynthetic process;GO:0033158|regulation of protein import into nucleus, translocation;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0090399|replicative senescence;GO:0046685|response to arsenic-containing substance;GO:0051412|response to corticosterone;GO:0042493|response to drug;GO:0055093|response to hyperoxia;GO:0010243|response to organonitrogen compound;GO:0009636|response to toxic substance;GO:0010165|response to X-ray;GO:0090400|stress-induced premature senescence;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0070557|PCNA-p21 complex;GO:0048471|perinuclear region of cytoplasm;GO:0032991|macromolecular complex;","GO:0030332|cyclin binding;GO:0019912|cyclin-dependent protein kinase activating kinase activity;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0046872|metal ion binding;GO:0019901|protein kinase binding;GO:0004860|protein kinase inhibitor activity;GO:0044877|macromolecular complex binding;GO:0031625|ubiquitin protein ligase binding;","K06625","CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A"]
["ENSG00000006756",102,139,116,83.9478365424131,50,32,42,3.35969191211386,1.74832894215749,1.25616232467096e-11,9.49034818576318e-11,"up","yes","ARSD","protein_coding","chrX:2903970-2929351:-","gi|71852584|ref|NP_001660.2|",2905,0,"arylsulfatase D isoform alpha precursor [Homo sapiens]","gi|339409226|ref|NM_001669.3|",5159,0,"Homo sapiens arylsulfatase D (ARSD), transcript variant 1, mRNA","P51689",1123,0,"Arylsulfatase D","MA2648",136,3e-32,"COG3119","pfam14707","Sulfatase_C","C-terminal region of aryl-sulfatase.","GO:0008152|metabolic process;","GO:0005788|endoplasmic reticulum lumen;GO:0005764|lysosome;","GO:0004065|arylsulfatase activity;GO:0046872|metal ion binding;","K12374","ARSD_F_H; arylsulfatase D/F/H [EC:3.1.6.-]"]
["ENSG00000101680",104,94,105,70.7559650672005,28,36,44,3.34920875072654,1.74382029967922,1.10345601469099e-12,8.92014233502091e-12,"up","yes","LAMA1","protein_coding","chr18:6941744-7117814:-","gi|38788416|ref|NP_005550.2|",14283,0,"laminin subunit alpha-1 precursor [Homo sapiens]","gi|219521577|gb|BC144590.1|",10341,0,"Homo sapiens cDNA clone IMAGE:9053120","P25391",5506,0,"Laminin subunit alpha-1",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0030198|extracellular matrix organization;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0045995|regulation of embryonic development;","GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005606|laminin-1 complex;GO:0005608|laminin-3 complex;GO:0016020|membrane;","GO:0005201|extracellular matrix structural constituent;GO:0008022|protein C-terminus binding;GO:0005102|receptor binding;","K05637","LAMA1_2; laminin, alpha 1/2"]
["ENSG00000135069",10398,10173,9465,7006.84333783771,2861,3516,4315,3.34556865275404,1.74225144936672,0,0,"up","yes","PSAT1","protein_coding","chr9:78297143-78330093:+","gi|397480457|ref|XP_003811498.1|",2033,0,"PREDICTED: phosphoserine aminotransferase isoform X1 [Pan paniscus]","gi|526479838|ref|NM_058179.3|",2188,0,"Homo sapiens phosphoserine aminotransferase 1 (PSAT1), transcript variant 1, mRNA","Q9Y617",741,0,"Phosphoserine aminotransferase","PA3167",363,2e-117,"COG1932","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006564|L-serine biosynthetic process;GO:0008615|pyridoxine biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0004648|O-phospho-L-serine:2-oxoglutarate aminotransferase activity;","K00831","serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]"]
["ENSG00000226608",60,87,61,48.5610784042822,17,24,34,3.3419690387998,1.74069836781655,1.7202939274674e-08,9.97325797204426e-08,"up","yes","FTLP3","processed_pseudogene","chr20:4023917-4024444:+","gi|20149498|ref|NP_000137.2|",767,3e-101,"ferritin light chain [Homo sapiens]","gi|169646235|ref|NG_002715.3|",528,0,"Homo sapiens ferritin, light polypeptide pseudogene 3 (FTLP3) on chromosome 20","P02792",300,1e-102,"Ferritin light chain","ECU06g1380",52.4,3e-08,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006880|intracellular sequestering of iron ion;GO:0055072|iron ion homeostasis;GO:0006826|iron ion transport;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0035578|azurophil granule lumen;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0016020|membrane;","GO:0008199|ferric iron binding;GO:0042802|identical protein binding;GO:0005506|iron ion binding;","K13625","FTL; ferritin light chain"]
["ENSG00000164010",45,27,40,25.9497201694241,5,16,20,3.331827597449,1.73631375162175,4.94523905157832e-05,0.000196545993873568,"up","yes","ERMAP","protein_coding","chr1:42817088-42844993:+","gi|19923536|ref|NP_061008.2|",2230,0,"erythroid membrane-associated protein precursor [Homo sapiens]","gi|31873243|emb|BX537371.1|",3931,0,"Homo sapiens mRNA; cDNA DKFZp686J23132 (from clone DKFZp686J23132)","Q96PL5",863,0,"Erythroid membrane-associated protein",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.",".","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K06712","BTN; butyrophilin"]
["ENSG00000185261",19,18,19,13.1077896686092,5,8,7,3.32720662868371,1.73431146433338,0.00207794222413558,0.00640961932178588,"up","yes","KIAA0825","protein_coding","chr5:94152966-94618597:-","gi|4240139|dbj|BAA74848.1|",2785,0,"KIAA0825 protein [Homo sapiens]","gi|4240138|dbj|AB020632.1|",5670,0,"Homo sapiens mRNA for KIAA0825 protein, partial cds",".",".",".",".",".",".",".",".","pfam14906","DUF4495","Domain of unknown function (DUF4495). This domain family is found in eukaryotes, and is typically between 322 and 336 amino acids in length. There are two conserved sequence motifs: QMW and DLW. Proteins in this family vary in length from 793 to 1184 amino acids.",".",".",".",".","."]
["ENSG00000196139",1348,1154,1125,845.437350689131,317,455,532,3.31843440301979,1.73050275611309,3.57921533805792e-110,2.69671505626801e-108,"up","yes","AKR1C3","protein_coding","chr10:5035354-5107686:+","gi|24497583|ref|NP_003730.4|",1740,0,"aldo-keto reductase family 1 member C3 isoform 1 [Homo sapiens]","gi|694938457|ref|XM_003312435.3|",1732,0,"PREDICTED: Pan troglodytes aldo-keto reductase family 1, member C3 (AKR1C3), mRNA","P42330",674,0,"Aldo-keto reductase family 1 member C3","YOR120w",210,4e-61,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0071276|cellular response to cadmium ion;GO:0071277|cellular response to calcium ion;GO:0071384|cellular response to corticosteroid stimulus;GO:0071395|cellular response to jasmonic acid stimulus;GO:0071799|cellular response to prostaglandin D stimulus;GO:0071379|cellular response to prostaglandin stimulus;GO:0034614|cellular response to reactive oxygen species;GO:0009267|cellular response to starvation;GO:0019371|cyclooxygenase pathway;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0016488|farnesol catabolic process;GO:0007186|G-protein coupled receptor signaling pathway;GO:0030216|keratinocyte differentiation;GO:0043170|macromolecule metabolic process;GO:0008584|male gonad development;GO:1900053|negative regulation of retinoic acid biosynthetic process;GO:0055114|oxidation-reduction process;GO:0010942|positive regulation of cell death;GO:0008284|positive regulation of cell proliferation;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:0051897|positive regulation of protein kinase B signaling;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:0042448|progesterone metabolic process;GO:0006693|prostaglandin metabolic process;GO:0000060|protein import into nucleus, translocation;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:2000224|regulation of testosterone biosynthetic process;GO:0070293|renal absorption;GO:0007584|response to nutrient;GO:0042574|retinal metabolic process;GO:0001523|retinoid metabolic process;GO:0008202|steroid metabolic process;GO:0061370|testosterone biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005622|intracellular;GO:0005634|nucleus;","GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0004033|aldo-keto reductase (NADP) activity;GO:0047023|androsterone dehydrogenase activity;GO:0047787|delta4-3-oxosteroid 5beta-reductase activity;GO:0035410|dihydrotestosterone 17-beta-dehydrogenase activity;GO:0045550|geranylgeranyl reductase activity;GO:0047718|indanol dehydrogenase activity;GO:0045703|ketoreductase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0052650|NADP-retinol dehydrogenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0036131|prostaglandin D2 11-ketoreductase activity;GO:0036130|prostaglandin H2 endoperoxidase reductase activity;GO:0047017|prostaglandin-F synthase activity;GO:0001758|retinal dehydrogenase activity;GO:0004745|retinol dehydrogenase activity;GO:0047045|testosterone 17-beta-dehydrogenase (NADP+) activity;GO:0047035|testosterone dehydrogenase (NAD+) activity;GO:0047115|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;","K04119","AKR1C3; aldo-keto reductase family 1 member C3 [EC:1.1.1.64 1.1.1.188 1.1.1.213]"]
["ENSG00000215769",10,18,13,9.61540050920186,3,5,7,3.3149632765327,1.72899288811837,0.00966426606505403,0.0257513007153192,"up","yes","ARHGAP27P1-BPTFP1-KPNA2P3","processed_transcript","chr17:64749663-64781707:-","gi|119614595|gb|EAW94189.1|",1181,2e-151,"hCG2002091, isoform CRA_c, partial [Homo sapiens]","gi|223890248|ref|NR_026899.1|",2732,0,"Homo sapiens Rho GTPase activating protein 27 pseudogene (LOC146880), transcript variant 2, non-coding RNA","Q12830",338,9e-96,"Nucleosome-remodeling factor subunit BPTF","SPBC1604.08c",104,5e-38,"COG5064","pfam01749","IBB","Importin beta binding domain. This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.","GO:0009952|anterior/posterior pattern specification;GO:0007420|brain development;GO:1990090|cellular response to nerve growth factor stimulus;GO:0006338|chromatin remodeling;GO:0001892|embryonic placenta development;GO:0007492|endoderm development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0009611|response to wounding;GO:0006351|transcription, DNA-templated;","GO:0044297|cell body;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0070062|extracellular exosome;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016589|NURF complex;GO:0048471|perinuclear region of cytoplasm;","GO:0046872|metal ion binding;GO:0035064|methylated histone binding;GO:0043565|sequence-specific DNA binding;GO:0008134|transcription factor binding;","K11728","BPTF, E(bx); nucleosome-remodeling factor subunit BPTF"]
["ENSG00000269069",33,20,28,18.9092835817229,8,10,11,3.30906614487663,1.72642412994956,0.000284833911851776,0.00101908300719663,"up","yes","AC007842.1","processed_pseudogene","chr19:40023384-40025502:-","gi|667270491|ref|XP_008570713.1|",1077,0,"PREDICTED: protein PAT1 homolog 1 [Galeopterus variegatus]","gi|955531918|ref|XM_004437421.2|",1484,0,"PREDICTED: Ceratotherium simum simum protein associated with topoisomerase II homolog 1 (yeast) (LOC101405896), mRNA","Q86TB9",418,0,"Protein PAT1 homolog 1",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.","GO:0033962|cytoplasmic mRNA processing body assembly;GO:0000290|deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0043928|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;","GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0000932|cytoplasmic mRNA processing body;GO:0016605|PML body;","GO:0034046|poly(G) binding;GO:0008266|poly(U) RNA binding;GO:0003723|RNA binding;","K12617","PATL1, PAT1; DNA topoisomerase 2-associated protein PAT1"]
["ENSG00000196517",630,696,595,450.013341129598,196,218,277,3.30633290184582,1.72523199131586,9.59729848341746e-61,3.371815904338e-59,"up","yes","SLC6A9","protein_coding","chr1:43991500-44031467:-","gi|67782317|ref|NP_001020016.1|",3169,0,"sodium- and chloride-dependent glycine transporter 1 isoform 3 [Homo sapiens]","gi|386869223|ref|NM_001024845.2|",3130,0,"Homo sapiens solute carrier family 6 member 9 (SLC6A9), transcript variant 3, mRNA","P48067",1208,0,"Sodium- and chloride-dependent glycine transporter 1","VC2012",211,2e-57,"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0061537|glycine secretion, neurotransmission;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0098793|presynapse;","GO:0015375|glycine:sodium symporter activity;GO:0005215|transporter activity;","K05038","SLC6A5S; solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14"]
["ENSG00000173930",360,298,329,230.681831579985,90,122,144,3.30614119976455,1.72514834103979,2.54182324435093e-35,5.23274405474856e-34,"up","yes","SLCO4C1","protein_coding","chr5:102233986-102296549:-","gi|38679890|ref|NP_851322.3|",3241,0,"solute carrier organic anion transporter family member 4C1 [Homo sapiens]","gi|38679889|ref|NM_180991.4|",5334,0,"Homo sapiens solute carrier organic anion transporter family member 4C1 (SLCO4C1), mRNA","Q6ZQN7",1253,0,"Solute carrier organic anion transporter family member 4C1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0043312|neutrophil degranulation;GO:0043252|sodium-independent organic anion transport;GO:0007283|spermatogenesis;","GO:0035577|azurophil granule membrane;GO:0016323|basolateral plasma membrane;GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0035579|specific granule membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K14355","SLCO4C; solute carrier organic anion transporter family, member 4C"]
["ENSG00000162998",8,15,13,8.52178014189723,4,4,5,3.30431525503802,1.72435133663112,0.0150220790426751,0.0383008407898372,"up","yes","FRZB","protein_coding","chr2:182833275-182867162:-","gi|507926526|ref|XP_004674522.1|",1605,0,"PREDICTED: secreted frizzled-related protein 3 [Condylura cristata]","gi|426337967|ref|XM_004032917.1|",3041,0,"PREDICTED: Gorilla gorilla gorilla frizzled-related protein (FRZB), mRNA","Q5RF67",597,0,"Secreted frizzled-related protein 3",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0090103|cochlea morphogenesis;GO:0060029|convergent extension involved in organogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0061037|negative regulation of cartilage development;GO:0010721|negative regulation of cell development;GO:0030308|negative regulation of cell growth;GO:0008285|negative regulation of cell proliferation;GO:0070367|negative regulation of hepatocyte differentiation;GO:0014033|neural crest cell differentiation;GO:0043065|positive regulation of apoptotic process;GO:0045600|positive regulation of fat cell differentiation;GO:0061053|somite development;GO:0016055|Wnt signaling pathway;","GO:0005576|extracellular region;","GO:0017147|Wnt-protein binding;",".","."]
["ENSG00000164707",17,12,9,8.73314288696441,2,4,8,3.30381179980722,1.72413150660662,0.0141396549830084,0.0363198382357527,"up","yes","SLC13A4","protein_coding","chr7:135681237-135729258:-","gi|62087198|dbj|BAD92046.1|",2365,0,"solute carrier family 13 (sodium/sulfate symporters), member 4 variant [Homo sapiens]","gi|62087197|dbj|AB208809.1|",7133,0,"Homo sapiens mRNA for solute carrier family 13 (sodium/sulfate symporters), member 4 variant protein","Q9UKG4",761,0,"Solute carrier family 13 member 4","SA1732",107,1e-22,"COG0471","pfam00939","Na_sulph_symp","Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.","GO:0098656|anion transmembrane transport;GO:0008272|sulfate transport;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015382|sodium:sulfate symporter activity;GO:0005215|transporter activity;","K14444","SLC13A1_4; solute carrier family 13 (sodium/sulfate cotransporter), member 1/4"]
["ENSG00000221955",67,61,51,41.5443836538262,11,21,34,3.29451757436039,1.72006722273454,1.76199432085384e-07,9.23765872808613e-07,"up","yes","SLC12A8","protein_coding","chr3:125082636-125212864:-","gi|21666316|gb|AAM73657.1|AF390442_1",3563,0,"solute carrier family 12 member 8 [Homo sapiens]","gi|306774091|ref|NM_001195483.1|",3444,0,"Homo sapiens solute carrier family 12 member 8 (SLC12A8), transcript variant 2, mRNA","A0AV02",1321,0,"Solute carrier family 12 member 8","MA4506",152,7e-37,"COG0531","pfam00324","AA_permease","Amino acid permease.",".","GO:0016021|integral component of membrane;","GO:0015379|potassium:chloride symporter activity;","K14428","SLC12A8, CCC9; solute carrier family 12 (potassium/chloride transporters), member 8"]
["ENSG00000260196",31,13,12,12.8689841035789,5,7,8,3.29175151055554,1.71885543295881,0.00401799967455337,0.0116557644341684,"up","yes","AC124798.1","antisense","chr11:17380649-17383531:+","gi|795202894|ref|XP_011848355.1|",276,7e-23,"PREDICTED: natural cytotoxicity triggering receptor 3 ligand 1 [Mandrillus leucophaeus]","gi|551871481|tpe|HG503570.1|",2883,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000421715.1 (RP1-239B22.5 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000173258",38,34,29,23.5661480922439,9,11,17,3.26824964275899,1.70851818685411,4.82314940294335e-05,0.00019208941912858,"up","yes","ZNF483","protein_coding","chr9:111525159-111577844:+","gi|190014620|ref|NP_597721.2|",3916,0,"zinc finger protein 483 isoform a [Homo sapiens]","gi|565671728|ref|NM_133464.3|",3655,0,"Homo sapiens zinc finger protein 483 (ZNF483), transcript variant 1, mRNA","Q8TF39",1513,0,"Zinc finger protein 483",".",".",".",".","pfam02023","SCAN","SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09229","ZKSCAN; KRAB and SCAN domains-containing zinc finger protein"]
["ENSG00000260027",33,27,35,22.3576703707335,7,16,12,3.2411689451637,1.69651422275307,0.000122538299203544,0.000461805141664312,"up","yes","HOXB7","protein_coding","chr17:48607227-48633572:-","gi|85068580|ref|NP_004493.3|",974,2e-127,"homeobox protein Hox-B7 [Homo sapiens]","gi|85068579|ref|NM_004502.3|",1366,0,"Homo sapiens homeobox B7 (HOXB7), mRNA","P09629",379,5e-129,"Homeobox protein Hox-B7",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0048704|embryonic skeletal system morphogenesis;GO:0007275|multicellular organismal development;GO:0030099|myeloid cell differentiation;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;","GO:0005829|cytosol;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09307","HOX_7; homeobox protein HoxA/B7"]
["ENSG00000280184",26,19,12,13.2086166223567,5,6,10,3.23606721559669,1.69424157396101,0.00307311234986235,0.00915572922523093,"up","yes","AL023806.3","TEC","chr6:145789270-145791973:-","gi|111599385|gb|AAI18597.1|",1012,5e-128,"FLJ44955 protein [Homo sapiens]","gi|3288443|emb|AL023806.1|",2704,0,"Human DNA sequence from clone RP3-466P17 on chromosome 6q24, complete sequence",".",".",".",".",".",".",".",".","pfam15279","SOBP","Sine oculis-binding protein. SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.",".",".",".",".","."]
["ENSG00000122641",204,194,180,136.170243075519,62,74,76,3.22290952762997,1.68836369014379,1.96001601363132e-21,2.48715716256059e-20,"up","yes","INHBA","protein_coding","chr7:41667168-41705834:-","gi|966933071|ref|XP_014989160.1|",2215,0,"PREDICTED: inhibin beta A chain isoform X1 [Macaca mulatta]","gi|694920749|ref|XM_519063.4|",5897,0,"PREDICTED: Pan troglodytes inhibin, beta A (INHBA), mRNA","P08476",816,0,"Inhibin beta A chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0032924|activin receptor signaling pathway;GO:0007050|cell cycle arrest;GO:0048468|cell development;GO:0030154|cell differentiation;GO:0007166|cell surface receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0071397|cellular response to cholesterol;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0006952|defense response;GO:0035987|endodermal cell differentiation;GO:0030218|erythrocyte differentiation;GO:0097191|extrinsic apoptotic signaling pathway;GO:0061029|eyelid development in camera-type eye;GO:0000082|G1/S transition of mitotic cell cycle;GO:0097154|GABAergic neuron differentiation;GO:0001942|hair follicle development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0042541|hemoglobin biosynthetic process;GO:0008584|male gonad development;GO:0048333|mesodermal cell differentiation;GO:0045578|negative regulation of B cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0030308|negative regulation of cell growth;GO:0008285|negative regulation of cell proliferation;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0045077|negative regulation of interferon-gamma biosynthetic process;GO:0045650|negative regulation of macrophage differentiation;GO:0042326|negative regulation of phosphorylation;GO:0007399|nervous system development;GO:0042476|odontogenesis;GO:0001541|ovarian follicle development;GO:0032270|positive regulation of cellular protein metabolic process;GO:0045648|positive regulation of erythrocyte differentiation;GO:2001241|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0046881|positive regulation of follicle-stimulating hormone secretion;GO:0010628|positive regulation of gene expression;GO:0060279|positive regulation of ovulation;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042701|progesterone secretion;GO:0046880|regulation of follicle-stimulating hormone secretion;GO:0043408|regulation of MAPK cascade;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0042493|response to drug;GO:0060021|palate development;GO:0060395|SMAD protein signal transduction;GO:0021773|striatal medium spiny neuron differentiation;","GO:0043509|activin A complex;GO:0005576|extracellular region;GO:0043512|inhibin A complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0042802|identical protein binding;GO:0034711|inhibin binding;GO:0017046|peptide hormone binding;GO:0046982|protein heterodimerization activity;GO:0005160|transforming growth factor beta receptor binding;GO:0070699|type II activin receptor binding;","K04667","INHB; inhibin, beta"]
["ENSG00000132702",7,20,11,9.05964070904364,4,6,4,3.21106423138128,1.68305152378945,0.0179070222897767,0.0446702852981392,"up","yes","HAPLN2","protein_coding","chr1:156619294-156625725:+","gi|11141887|ref|NP_068589.1|",1706,0,"hyaluronan and proteoglycan link protein 2 precursor [Homo sapiens]","gi|46852179|ref|NM_021817.2|",1771,0,"Homo sapiens hyaluronan and proteoglycan link protein 2 (HAPLN2), mRNA","Q9GZV7",661,0,"Hyaluronan and proteoglycan link protein 2",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0008065|establishment of blood-nerve barrier;GO:0085029|extracellular matrix assembly;GO:0001501|skeletal system development;","GO:0005576|extracellular region;","GO:0005201|extracellular matrix structural constituent;GO:0005540|hyaluronic acid binding;","K06851","HAPLN2; hyaluronan and proteoglycan link protein 2"]
["ENSG00000139865",18,14,18,11.9198342649754,9,4,5,3.19200419385972,1.67446254706673,0.00618784801940616,0.0172647493994367,"up","yes","TTC6","protein_coding","chr14:37595847-38041442:+","gi|856116667|ref|NP_001297064.1|",9770,0,"tetratricopeptide repeat protein 6 [Homo sapiens]","gi|856116666|ref|NM_001310135.1|",5833,0,"Homo sapiens tetratricopeptide repeat domain 6 (TTC6), mRNA",".",".",".",".","MA1613",182,3e-45,"COG0457","pfam13414","TPR_11","TPR repeat.",".",".",".",".","."]
["ENSG00000120949",12,12,16,9.49979468436021,4,5,6,3.19125043549685,1.67412182951108,0.0112363464416986,0.0295428912442043,"up","yes","TNFRSF8","protein_coding","chr1:12063377-12144207:+","gi|597709795|ref|NP_001234.3|",2736,0,"tumor necrosis factor receptor superfamily member 8 isoform 1 precursor [Homo sapiens]","gi|597709794|ref|NM_001243.4|",3686,0,"Homo sapiens tumor necrosis factor receptor superfamily member 8 (TNFRSF8), transcript variant 1, mRNA","P28908",1056,0,"Tumor necrosis factor receptor superfamily member 8",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0097190|apoptotic signaling pathway;GO:0007411|axon guidance;GO:0071260|cellular response to mechanical stimulus;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0008285|negative regulation of cell proliferation;GO:0010977|negative regulation of neuron projection development;GO:0043065|positive regulation of apoptotic process;GO:0045556|positive regulation of TRAIL biosynthetic process;GO:0042535|positive regulation of tumor necrosis factor biosynthetic process;GO:0032496|response to lipopolysaccharide;GO:0007165|signal transduction;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0048406|nerve growth factor binding;GO:0004888|transmembrane signaling receptor activity;GO:0005031|tumor necrosis factor-activated receptor activity;","K05145","TNFRSF8, CD30; tumor necrosis factor receptor superfamily member 8"]
["ENSG00000273576",20,24,17,14.3488533480003,4,10,9,3.18392731541793,1.67080740155901,0.00211148447863186,0.00649853400731631,"up","yes","AC009283.1","lincRNA","chr17:39566915-39567559:+",".",".",".",".","gi|767995044|ref|XM_011524907.1|",645,0,"PREDICTED: Homo sapiens cyclin-dependent kinase 12 (CDK12), transcript variant X17, mRNA",".",".",".",".",".",".",".",".","pfam05090","VKG_Carbox","Vitamin K-dependent gamma-carboxylase. Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase.",".",".",".",".","."]
["ENSG00000227234",59,49,33,33.0850669652512,18,13,21,3.18102367547355,1.6694911094949,6.50497372185149e-06,2.89764279785384e-05,"up","yes","SPANXB1","protein_coding","chrX:141002591-141003706:+","gi|608601818|ref|NP_115850.2|",397,1e-46,"sperm protein associated with the nucleus on the X chromosome B1 [Homo sapiens]","gi|608601817|ref|NM_032461.3|",469,0,"Homo sapiens SPANX family member B1 (SPANXB1), mRNA","Q9NS25",157,4e-48,"Sperm protein associated with the nucleus on the X chromosome B1",".",".",".",".","pfam07458","SPAN-X","Sperm protein associated with nucleus, mapped to X chromosome. This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumors but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.","GO:0007286|spermatid development;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["ENSG00000153930",58,84,77,51.9986184280977,21,25,37,3.17882610485129,1.66849409715202,2.07884464006788e-08,1.19763307699012e-07,"up","yes","ANKFN1","protein_coding","chr17:55882301-56511659:+","gi|767993806|ref|XP_011522730.1|",6032,0,"PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X4 [Homo sapiens]","gi|767993805|ref|XM_011524428.1|",3588,0,"PREDICTED: Homo sapiens ankyrin-repeat and fibronectin type III domain containing 1 (ANKFN1), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSG00000257150",22,12,14,11.2600564494514,7,1,10,3.16259882049166,1.66111055984042,0.011052168174025,0.0291073914043632,"up","yes","PGAM1P5","transcribed_processed_pseudogene","chr12:95551582-95673999:+","gi|685563706|ref|XP_003904124.2|",543,2e-95,"PREDICTED: phosphoglycerate mutase 1 [Papio anubis]","gi|452085197|ref|NR_077225.1|",2148,0,"Homo sapiens phosphoglycerate mutase 1 pseudogene 5 (PGAM1P5), non-coding RNA","Q8N0Y7",204,6e-92,"Probable phosphoglycerate mutase 4","YPO1133",134,1e-34,"COG0588","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:1902093|positive regulation of sperm motility;GO:0043456|regulation of pentose-phosphate shunt;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0097228|sperm principal piece;","GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0004082|bisphosphoglycerate mutase activity;GO:0016787|hydrolase activity;GO:0004619|phosphoglycerate mutase activity;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["ENSG00000100271",44,30,52,29.9388233593727,14,12,22,3.14627009802567,1.65364252719217,2.41336855453991e-05,0.000100391810039611,"up","yes","TTLL1","protein_coding","chr22:43039644-43089428:-","gi|675641665|ref|XP_008978035.1|",2265,0,"PREDICTED: probable tubulin polyglutamylase TTLL1 isoform X1 [Callithrix jacchus]","gi|768024498|ref|XM_011530108.1|",1673,0,"PREDICTED: Homo sapiens tubulin tyrosine ligase-like family member 1 (TTLL1), transcript variant X1, mRNA","O95922",865,0,"Probable tubulin polyglutamylase TTLL1",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0003351|epithelial cilium movement;GO:0018095|protein polyglutamylation;GO:0007288|sperm axoneme assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005524|ATP binding;GO:0070740|tubulin-glutamic acid ligase activity;","K16599","TTLL1; tubulin polyglutamylase TTLL1 [EC:6.-.-.-]"]
["ENSG00000006459",1154,970,993,736.905977805983,306,392,486,3.13721777524179,1.64948567975733,3.31060027154032e-94,2.02072335561613e-92,"up","yes","KDM7A","protein_coding","chr7:140084746-140177035:-","gi|90093355|ref|NP_085150.1|",4662,0,"lysine-specific demethylase 7A [Homo sapiens]","gi|90093354|ref|NM_030647.1|",9178,0,"Homo sapiens lysine demethylase 7A (KDM7A), mRNA","Q6ZMT4",1796,0,"Lysine-specific demethylase 7A",".",".",".",".","pfam00628","PHD","PHD-finger. PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.","GO:0071557|histone H3-K27 demethylation;GO:0070544|histone H3-K36 demethylation;GO:0033169|histone H3-K9 demethylation;GO:0035574|histone H4-K20 demethylation;GO:0030901|midbrain development;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0032452|histone demethylase activity;GO:0071558|histone demethylase activity (H3-K27 specific);GO:0051864|histone demethylase activity (H3-K36 specific);GO:0032454|histone demethylase activity (H3-K9 specific);GO:0035575|histone demethylase activity (H4-K20 specific);GO:0005506|iron ion binding;GO:0035064|methylated histone binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0008270|zinc ion binding;","K11445","KDM7A, JHDM1D; lysine-specific demethylase 7A [EC:1.14.11.-]"]
["ENSG00000235897",107,108,114,78.0074413935903,29,43,54,3.13614025621055,1.64899008190676,1.77890265764308e-12,1.41607405945603e-11,"up","yes","TM4SF19-AS1","antisense","chr3:196318330-196325570:+","gi|119574049|gb|EAW53664.1|",538,2e-62,"hCG1797104 [Homo sapiens]","gi|657406305|ref|NR_046724.1|",1829,0,"Homo sapiens TM4SF19 antisense RNA 1 (TM4SF19-AS1), transcript variant 1, long non-coding RNA","Q96DZ7",95.5,1e-20,"Transmembrane 4 L6 family member 19",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000204386",940,953,936,670.989635406261,274,346,463,3.12864582499391,1.64553834907244,2.86080268800062e-82,1.4520832170041e-80,"up","yes","NEU1","protein_coding","chr6:31857659-31862906:-","gi|62087602|dbj|BAD92248.1|",789,1e-93,"neuraminidase precursor variant [Homo sapiens]","gi|62087601|dbj|AB209011.1|",4448,0,"Homo sapiens mRNA for neuraminidase precursor variant protein","Q5RAF4",298,1e-87,"Sialidase-1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0016042|lipid catabolic process;GO:0009313|oligosaccharide catabolic process;","GO:0031410|cytoplasmic vesicle;GO:0043202|lysosomal lumen;GO:0005765|lysosomal membrane;GO:0005764|lysosome;GO:0005886|plasma membrane;","GO:0052794|exo-alpha-(2->3)-sialidase activity;GO:0052795|exo-alpha-(2->6)-sialidase activity;GO:0052796|exo-alpha-(2->8)-sialidase activity;GO:0004308|exo-alpha-sialidase activity;","K01186","NEU1; sialidase-1 [EC:3.2.1.18]"]
["ENSG00000089820",56,51,37,34.1740881086689,23,14,16,3.12844692715424,1.64544662950286,1.01920493913736e-05,4.44660141734481e-05,"up","yes","ARHGAP4","protein_coding","chrX:153907367-153934999:-","gi|258613907|ref|NP_001158213.1|",4508,0,"rho GTPase-activating protein 4 isoform 1 [Homo sapiens]","gi|258613906|ref|NM_001164741.1|",3372,0,"Homo sapiens Rho GTPase activating protein 4 (ARHGAP4), transcript variant 1, mRNA","P98171",1632,0,"Rho GTPase-activating protein 4",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007010|cytoskeleton organization;GO:0030517|negative regulation of axon extension;GO:0030336|negative regulation of cell migration;GO:0010764|negative regulation of fibroblast migration;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007266|Rho protein signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0030426|growth cone;GO:0005874|microtubule;","GO:0005096|GTPase activator activity;GO:0042802|identical protein binding;GO:0048365|Rac GTPase binding;GO:0005070|SH3/SH2 adaptor activity;",".","."]
["ENSG00000107187",17,12,13,9.96210282247634,5,5,6,3.09419933638914,1.62956614195712,0.0109167422712383,0.0287967895141745,"up","yes","LHX3","protein_coding","chr9:136196250-136205128:-","gi|109109777|ref|XP_001096075.1|",1497,0,"PREDICTED: LIM/homeobox protein Lhx3 [Macaca mulatta]","gi|326205259|dbj|AB593065.1|",3079,0,"Homo sapiens LHX3 mRNA for LIM/homeobox protein Lhx3, complete cds, clone: HP05297-RBd40E03","Q9UBR4",565,0,"LIM/homeobox protein Lhx3","ECU04g1030",56.2,4e-08,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0009887|organ morphogenesis;GO:0048839|inner ear development;GO:0030324|lung development;GO:0021526|medial motor column neuron differentiation;GO:0008045|motor neuron axon guidance;GO:0043066|negative regulation of apoptotic process;GO:0021983|pituitary gland development;GO:0001890|placenta development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0021527|spinal cord association neuron differentiation;GO:0021520|spinal cord motor neuron cell fate specification;GO:0021521|ventral spinal cord interneuron specification;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0046872|metal ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0001076|transcription factor activity, RNA polymerase II transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09374","LHX3_4; LIM homeobox protein 3/4"]
["ENSG00000256967",42,34,37,26.771637200761,9,16,19,3.08416508644514,1.62487999061655,3.63524131464447e-05,0.000147303643858955,"up","yes","AC018653.3","antisense","chr12:7129079-7131198:-",".",".",".",".","gi|551873152|tpe|HG504464.1|",749,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000398558.1 (RP11-273B20.1 gene), antisense",".",".",".",".",".",".",".",".","pfam07271","Cytadhesin_P30","Cytadhesin P30/P32. This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localized on the tip organelle. It is thought that it is important in cytadherence and virulence.",".",".",".",".","."]
["ENSG00000123496",38,32,41,26.5059299490444,12,14,17,3.07433131397742,1.6202726495035,4.28078435761979e-05,0.000171622882331678,"up","yes","IL13RA2","protein_coding","chrX:115003975-115019977:-","gi|10834992|ref|NP_000631.1|",2022,0,"interleukin-13 receptor subunit alpha-2 precursor [Homo sapiens]","gi|694986008|ref|XM_009439548.1|",1389,0,"PREDICTED: Pan troglodytes interleukin 13 receptor, alpha 2 (IL13RA2), mRNA","Q14627",783,0,"Interleukin-13 receptor subunit alpha-2",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0019221|cytokine-mediated signaling pathway;GO:0016064|immunoglobulin mediated immune response;GO:0002638|negative regulation of immunoglobulin production;GO:0043305|negative regulation of mast cell degranulation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;","K05077","IL13RA2; interleukin 13 receptor alpha-2"]
["ENSG00000162849",57,45,41,33.9357985599767,17,16,22,3.07121830321298,1.61881106319927,3.90872157763279e-06,1.7831462107233e-05,"up","yes","KIF26B","protein_coding","chr1:245154985-245709431:+","gi|767912502|ref|XP_011542520.1|",7695,0,"PREDICTED: kinesin-like protein KIF26B isoform X3 [Homo sapiens]","gi|767912501|ref|XM_011544218.1|",12113,0,"PREDICTED: Homo sapiens kinesin family member 26B (KIF26B), transcript variant X5, mRNA","Q2KJY2",2945,0,"Kinesin-like protein KIF26B","YGL216w",102,1e-20,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0030010|establishment of cell polarity;GO:0022409|positive regulation of cell-cell adhesion;GO:0072092|ureteric bud invasion;","GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10404","KIF26; kinesin family member 26"]
["ENSG00000052802",4477,4292,4037,3052.84073278848,1310,1660,2036,3.04938632217181,1.6085189347935,0,0,"up","yes","MSMO1","protein_coding","chr4:165327623-165343160:+","gi|5803157|ref|NP_006736.1|",1520,0,"methylsterol monooxygenase 1 isoform 1 [Homo sapiens]","gi|345525410|ref|NM_006745.4|",2226,0,"Homo sapiens methylsterol monooxygenase 1 (MSMO1), transcript variant 1, mRNA","Q5R574",590,0,"Methylsterol monooxygenase 1","SPAC630.08c",189,5e-53,"COG3000","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.","GO:0016126|sterol biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;","K07750","E1.14.13.72, SC4MOL, ERG25; methylsterol monooxygenase [EC:1.14.13.72]"]
["ENSG00000171450",107,130,95,79.1587438599973,32,46,52,3.04798061395518,1.60785372689959,9.68456819765001e-12,7.35127711122682e-11,"up","yes","CDK5R2","protein_coding","chr2:218959655-218962162:+","gi|478506663|ref|XP_004427626.1|",1194,3e-153,"PREDICTED: cyclin-dependent kinase 5 activator 2 [Ceratotherium simum simum]","gi|17136161|gb|AC097468.3|",2508,0,"Homo sapiens BAC clone RP11-33O4 from 2, complete sequence","Q13319",459,1e-152,"Cyclin-dependent kinase 5 activator 2",".",".",".",".","pfam03261","CDK5_activator","Cyclin-dependent kinase 5 activator protein.","GO:0021549|cerebellum development;GO:0021766|hippocampus development;GO:0021819|layer formation in cerebral cortex;GO:0001764|neuron migration;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0021722|superior olivary nucleus maturation;","GO:0016533|cyclin-dependent protein kinase 5 holoenzyme complex;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0016534|cyclin-dependent protein kinase 5 activator activity;GO:0008289|lipid binding;",".","."]
["ENSG00000140873",29,18,18,15.4113952697086,7,10,8,3.0473579895482,1.60755899113318,0.00213276388467171,0.00655565733984827,"up","yes","ADAMTS18","protein_coding","chr16:77247813-77435114:-","gi|40806187|ref|NP_955387.1|",6363,0,"A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein [Homo sapiens]","gi|149158721|ref|NM_199355.2|",5910,0,"Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 18 (ADAMTS18), mRNA","Q8TE60",2448,0,"A disintegrin and metalloproteinase with thrombospondin motifs 18",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0001654|eye development;GO:0090331|negative regulation of platelet aggregation;","GO:0005576|extracellular region;","GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;","K08632","ADAMTS18; a disintegrin and metalloproteinase with thrombospondin motifs 18 [EC:3.4.24.-]"]
["ENSG00000225434",14,10,22,11.2277041564846,11,2,4,3.04581348690012,1.60682759981509,0.0195336248958139,0.0481672918678673,"up","yes","LINC01504","lincRNA","chr9:72305430-72343210:+","gi|119582936|gb|EAW62532.1|",684,1e-82,"hCG2038076, partial [Homo sapiens]","gi|594191234|ref|NR_110952.1|",2078,0,"Homo sapiens long intergenic non-protein coding RNA 1504 (LINC01504), transcript variant 1, long non-coding RNA","Q8N9U9",53.1,7e-07,"Putative uncharacterized protein SPANXA2-OT1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0043065|positive regulation of apoptotic process;","GO:0005739|mitochondrion;","GO:0008017|microtubule binding;",".","."]
["ENSG00000117586",30,18,24,17.1287388465029,8,9,11,3.04456108367285,1.60623425832855,0.00114115375273328,0.00369242972365703,"up","yes","TNFSF4","protein_coding","chr1:173183734-173207313:-","gi|686701073|ref|XP_009239104.1|",988,3e-122,"PREDICTED: tumor necrosis factor ligand superfamily member 4 isoform X1 [Pongo abelii]","gi|662033900|ref|NM_003326.4|",3470,0,"Homo sapiens tumor necrosis factor superfamily member 4 (TNFSF4), transcript variant 1, mRNA","P23510",375,2e-120,"Tumor necrosis factor ligand superfamily member 4",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002526|acute inflammatory response;GO:0071222|cellular response to lipopolysaccharide;GO:0071380|cellular response to prostaglandin E stimulus;GO:0071954|chemokine (C-C motif) ligand 11 production;GO:0002215|defense response to nematode;GO:0006955|immune response;GO:0035709|memory T cell activation;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0032689|negative regulation of interferon-gamma production;GO:0032700|negative regulation of interleukin-17 production;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0045626|negative regulation of T-helper 1 cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0050871|positive regulation of B cell activation;GO:1900281|positive regulation of CD4-positive, alpha-beta T cell costimulation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0008284|positive regulation of cell proliferation;GO:0002891|positive regulation of immunoglobulin mediated immune response;GO:0051024|positive regulation of immunoglobulin secretion;GO:0050729|positive regulation of inflammatory response;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:2000572|positive regulation of interleukin-4-dependent isotype switching to IgE isotypes;GO:0032755|positive regulation of interleukin-6 production;GO:0043382|positive regulation of memory T cell differentiation;GO:0002726|positive regulation of T cell cytokine production;GO:0042102|positive regulation of T cell proliferation;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0002830|positive regulation of type 2 immune response;GO:0002819|regulation of adaptive immune response;GO:0050727|regulation of inflammatory response;GO:0035713|response to nitrogen dioxide;GO:0009615|response to virus;GO:0007165|signal transduction;GO:0035712|T-helper 2 cell activation;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0009986|cell surface;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0005125|cytokine activity;GO:0005102|receptor binding;GO:0005164|tumor necrosis factor receptor binding;GO:0032813|tumor necrosis factor receptor superfamily binding;","K05469","TNFSF4, OX40L; tumor necrosis factor ligand superfamily member 4"]
["ENSG00000162496",73,85,69,54.110161358171,20,29,41,3.03684066702033,1.60257121705666,1.14285600934846e-08,6.72260039899757e-08,"up","yes","DHRS3","protein_coding","chr1:12567910-12617731:-","gi|31543615|ref|NP_004744.2|",1606,0,"short-chain dehydrogenase/reductase 3 isoform 1 [Homo sapiens]","gi|611434981|ref|NM_004753.6|",1722,0,"Homo sapiens dehydrogenase/reductase (SDR family) member 3 (DHRS3), transcript variant 1, mRNA","O75911",623,0,"Short-chain dehydrogenase/reductase 3",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0060349|bone morphogenesis;GO:0060411|cardiac septum morphogenesis;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;GO:0003151|outflow tract morphogenesis;GO:0030278|regulation of ossification;GO:0001523|retinoid metabolic process;GO:0042572|retinol metabolic process;GO:0060021|palate development;GO:0007601|visual perception;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0042622|photoreceptor outer segment membrane;","GO:0009055|electron carrier activity;GO:0052650|NADP-retinol dehydrogenase activity;GO:0000166|nucleotide binding;GO:0004745|retinol dehydrogenase activity;","K11146","DHRS3; short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]"]
["ENSG00000178462",24,39,32,22.8041911911881,9,11,18,3.02568236554485,1.5972605421793,0.00026409418796491,0.00094999043220201,"up","yes","TUBAL3","protein_coding","chr10:5393098-5404830:-","gi|13376181|ref|NP_079079.1|",2265,0,"tubulin alpha chain-like 3 isoform 1 [Homo sapiens]","gi|285395212|ref|NM_024803.2|",1798,0,"Homo sapiens tubulin alpha like 3 (TUBAL3), transcript variant 1, mRNA","A6NHL2",876,0,"Tubulin alpha chain-like 3","SPBC800.05c",618,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07374","TUBA; tubulin alpha"]
["ENSG00000229431",24,23,11,13.6591805464851,2,13,8,3.02453561130698,1.59671364728122,0.00733652083942826,0.0201089688718051,"up","yes","AL139289.1","antisense","chr1:43385113-43389155:+","gi|568929958|ref|XP_006503554.1|",254,1e-22,"PREDICTED: mediator of RNA polymerase II transcription subunit 8 isoform X2 [Mus musculus]","gi|551896095|tpe|HG491959.1|",731,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000091291.1 (RP1-92O14.6 gene), antisense","Q96G25",99.8,3e-23,"Mediator of RNA polymerase II transcription subunit 8",".",".",".",".","pfam10232","Med8","Mediator of RNA polymerase II transcription complex subunit 8. Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.","GO:0016567|protein ubiquitination;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0016592|mediator complex;GO:0005654|nucleoplasm;","GO:0001104|RNA polymerase II transcription cofactor activity;","K15129","MED8; mediator of RNA polymerase II transcription subunit 8"]
["ENSG00000273079",18,11,14,10.2279581107188,4,6,7,3.01489461548249,1.5921075741393,0.0118150954125289,0.0309422349377946,"up","yes","GRIN2B","protein_coding","chr12:13437942-13981957:-","gi|795590339|ref|XP_011913889.1|",7862,0,"PREDICTED: glutamate receptor ionotropic, NMDA 2B isoform X1 [Cercocebus atys]","gi|767971847|ref|XM_011520630.1|",30350,0,"PREDICTED: Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), transcript variant X3, mRNA","Q13224",3025,0,"Glutamate receptor ionotropic, NMDA 2B",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0007420|brain development;GO:0097553|calcium ion transmembrane import into cytosol;GO:0007268|synaptic transmission;GO:0048013|ephrin receptor signaling pathway;GO:0007215|glutamate receptor signaling pathway;GO:0007611|learning or memory;GO:0000165|MAPK cascade;GO:0007275|multicellular organismal development;GO:1902951|negative regulation of dendritic spine maintenance;GO:2001056|positive regulation of cysteine-type endopeptidase activity;GO:1901216|positive regulation of neuron death;GO:0051290|protein heterotetramerization;GO:0048167|regulation of synaptic plasticity;GO:0045471|response to ethanol;","GO:0030054|cell junction;GO:0009986|cell surface;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0043005|neuron projection;GO:0017146|NMDA selective glutamate receptor complex;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0097060|synaptic membrane;","GO:0005234|extracellular-glutamate-gated ion channel activity;GO:0016595|glutamate binding;GO:0022849|glutamate-gated calcium ion channel activity;GO:0016594|glycine binding;GO:0004972|NMDA glutamate receptor activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0008270|zinc ion binding;","K05210","GRIN2B; glutamate receptor ionotropic, NMDA 2B"]
["ENSG00000115919",4603,4158,4174,3093.46779382717,1380,1645,2090,3.01185815155853,1.59065382550054,9.82132233166657e-299,3.444248456967e-296,"up","yes","KYNU","protein_coding","chr2:142877498-143055832:+","gi|4504937|ref|NP_003928.1|",2432,0,"kynureninase isoform a [Homo sapiens]","gi|14589691|gb|AC013437.8|",13786,0,"Homo sapiens BAC clone RP11-190J23 from 2, complete sequence","Q16719",941,0,"Kynureninase","YLR231c",342,1e-101,"COG3844","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0043420|anthranilate metabolic process;GO:0097053|L-kynurenine catabolic process;GO:0009435|NAD biosynthetic process;GO:0019805|quinolinate biosynthetic process;GO:0034341|response to interferon-gamma;GO:0034516|response to vitamin B6;GO:0006569|tryptophan catabolic process;GO:0019442|tryptophan catabolic process to acetyl-CoA;GO:0019441|tryptophan catabolic process to kynurenine;","GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;","GO:0030429|kynureninase activity;GO:0042803|protein homodimerization activity;GO:0030170|pyridoxal phosphate binding;","K01556","KYNU, kynU; kynureninase [EC:3.7.1.3]"]
["ENSG00000251562",4033,3702,3775,2755.34434876695,1113,1710,1743,3.00697667416127,1.58831367662413,1.12916075050806e-53,3.52986265085889e-52,"up","yes","MALAT1","lincRNA","chr11:65497688-65506516:+","gi|9910794|sp|Q9UHZ2.1|MALAT_HUMAN",275,9e-25,"RecName: Full=Metastasis-associated lung adenocarcinoma transcript 1","gi|764020144|ref|NR_002819.3|",8708,0,"Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA",".",".",".",".",".",".",".",".","pfam14093","DUF4271","Domain of unknown function (DUF4271). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 221 and 326 amino acids in length.",".",".",".",".","."]
["ENSG00000268041",36,25,34,22.8484136356305,15,8,14,3.0038875139873,1.5868307895329,0.000324448966833003,0.00115023045880313,"up","yes","AC010616.1","protein_coding","chr19:41907705-41928516:-","gi|755797214|ref|XP_011288262.1|",1385,0,"PREDICTED: ETS translocation variant 3-like protein [Felis catus]","gi|767899676|ref|XM_005276651.3|",1684,0,"PREDICTED: Homo sapiens Ets2 repressor factor-like (LOC390937), mRNA","P70459",239,4e-68,"ETS domain-containing transcription factor ERF",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0060710|chorio-allantoic fusion;GO:0010668|ectodermal cell differentiation;GO:0001701|in utero embryonic development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;GO:0060707|trophoblast giant cell differentiation;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003714|transcription corepressor activity;","K09434","ERF; ETS domain-containing transcription factor ERF"]
["ENSG00000183671",125,153,143,101.395251484788,49,54,64,2.99740516056634,1.58371410675203,4.82422309797972e-14,4.22952795971967e-13,"up","yes","GPR1","protein_coding","chr2:206175316-206218047:-","gi|114051686|ref|NP_001040594.1|",1578,0,"G-protein coupled receptor 1 [Macaca mulatta]","gi|387763598|ref|NM_001261453.1|",2565,0,"Homo sapiens G protein-coupled receptor 1 (GPR1), transcript variant 4, mRNA","O97664",612,0,"G-protein coupled receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007268|synaptic transmission;GO:0007187|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007218|neuropeptide signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;GO:0005654|nucleoplasm;","GO:0004930|G-protein coupled receptor activity;GO:0042923|neuropeptide binding;","K04310","GPR1; G protein-coupled receptor 1"]
["ENSG00000196972",33,22,31,20.6196806088869,10,11,13,2.99667696166278,1.58336357136373,0.000432219799074298,0.00150210008730542,"up","yes","SMIM10L2B","protein_coding","chrX:135094987-135098634:-","gi|795344149|ref|XP_011930329.1|",432,3e-45,"PREDICTED: uncharacterized protein LOC105592667 [Cercocebus atys]","gi|933128133|ref|NR_024493.2|",2737,0,"Homo sapiens small integral membrane protein 10 like 2B (SMIM10L2B), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15118","DUF4560","Domain of unknown function (DUF4560). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 66 and 78 amino acids in length. There are two conserved sequence motifs: FCK and RTL.",".",".",".",".","."]
["ENSG00000272405",526,520,538,380.271481362643,151,222,264,2.98031469315939,1.57546467373785,1.79991234876459e-45,4.74920784992769e-44,"up","yes","AL365181.3","antisense","chr1:156641666-156644887:-","gi|119573317|gb|EAW52932.1|",650,2e-74,"hCG2042268, partial [Homo sapiens]","gi|551898332|tpe|HG492812.1|",3222,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000470702.1 (RP11-284F21.10 gene), antisense",".",".",".",".",".",".",".",".","pfam07925","RdRP_5","Reovirus RNA-dependent RNA polymerase lambda 3. The sequences in this family are similar to the reoviral minor core protein lambda 3, which functions as a RNA-dependent RNA polymerase within the protein capsid.  It is organized into 3 domains. N- and C-terminal domains create a 'cage' that encloses a conserved central catalytic domain within a hollow centre; this catalytic domain is arranged to form 'fingers', 'palm' and 'thumb' subdomains. Unlike other RNA polymerases, like HIV reverse transcriptase and T7 RNA polymerase, lambda 3 protein binds template and substrate with only localized rearrangements, and catalytic activity can occur with little structural change. However, the structure of the catalytic complex is similar to that of other polymerase catalytic complexes with known structure.",".",".",".",".","."]
["ENSG00000278952",22,20,20,15.0124783625027,10,9,5,2.96806923668681,1.56952474635887,0.00360954514194236,0.0105855111293575,"up","yes","AP003068.4","TEC","chr11:65118310-65119111:+","gi|355561739|gb|EHH18371.1|",149,2e-09,"hypothetical protein EGK_14950, partial [Macaca mulatta]","gi|31790648|dbj|AP003068.3|",802,0,"Homo sapiens genomic DNA, chromosome 11 clone:RP11-399J13, complete sequence","Q6B4Z3",55.1,3e-07,"Histone demethylase UTY",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0010468|regulation of gene expression;","GO:0005634|nucleus;","GO:0051213|dioxygenase activity;GO:0071558|histone demethylase activity (H3-K27 specific);GO:0046872|metal ion binding;","K11447","UTX, UTY; histone demethylase [EC:1.14.11.-]"]
["ENSG00000196358",199,226,215,154.065738602442,69,74,116,2.96496249875325,1.56801385748465,1.05190684635054e-19,1.24092839464277e-18,"up","yes","NTNG2","protein_coding","chr9:132161676-132244534:+","gi|471370648|ref|XP_004375836.1|",2485,0,"PREDICTED: netrin-G2 [Trichechus manatus latirostris]","gi|767958499|ref|XM_011519107.1|",4500,0,"PREDICTED: Homo sapiens netrin G2 (NTNG2), transcript variant X15, mRNA","Q96CW9",957,0,"Netrin-G2",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0007409|axonogenesis;","GO:0046658|anchored component of plasma membrane;GO:0030424|axon;GO:0005829|cytosol;GO:0005576|extracellular region;GO:0090543|Flemming body;GO:0045171|intercellular bridge;GO:0005886|plasma membrane;",".","K16359","NTNG2; netrin-G2"]
["ENSG00000256043",51,54,60,39.7910556303237,20,14,33,2.96132821214609,1.56624439723426,3.23503715230654e-06,1.49062103663852e-05,"up","yes","CTSO","protein_coding","chr4:155924118-155953917:-","gi|119625288|gb|EAX04883.1|",1592,0,"cathepsin O [Homo sapiens]","gi|38327639|ref|NM_001334.2|",2933,0,"Homo sapiens cathepsin O (CTSO), mRNA","P43234",619,0,"Cathepsin O","AF1946_2",82.4,4e-16,"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0006508|proteolysis;GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004197|cysteine-type endopeptidase activity;","K01374","CTSO; cathepsin O [EC:3.4.22.42]"]
["ENSG00000198598",111,120,82,74.7903033121926,31,30,67,2.95491495555296,1.56311660926319,1.4346453465828e-09,9.14456029242861e-09,"up","yes","MMP17","protein_coding","chr12:131828393-131851783:+","gi|112382270|ref|NP_057239.4|",2561,0,"matrix metalloproteinase-17 preproprotein [Homo sapiens]","gi|975830146|ref|NM_016155.5|",2408,0,"Homo sapiens matrix metallopeptidase 17 (MMP17), mRNA","Q9ULZ9",990,0,"Matrix metalloproteinase-17",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0042756|drinking behavior;GO:0001822|kidney development;GO:0006508|proteolysis;","GO:0031225|anchored component of membrane;GO:0031012|extracellular matrix;GO:0005887|integral component of plasma membrane;","GO:0008047|enzyme activator activity;GO:0070006|metalloaminopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K07997","MMP17; matrix metalloproteinase-17 (membrane-inserted) [EC:3.4.24.-]"]
["ENSG00000134343",15,15,14,10.5629555849439,3,8,7,2.93843268885675,1.55504685066125,0.0124524148127414,0.0324482811278244,"up","yes","ANO3","protein_coding","chr11:26309599-26663288:+","gi|156766084|ref|NP_113606.2|",4964,0,"anoctamin-3 isoform 2 [Homo sapiens]","gi|13160035|emb|AJ300461.1|",6602,0,"Homo sapiens mRNA for C11ORF25 gene","Q9BYT9",1916,0,"Anoctamin-3",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0061591|calcium activated galactosylceramide scrambling;GO:0061590|calcium activated phosphatidylcholine scrambling;GO:0050982|detection of mechanical stimulus;GO:0016048|detection of temperature stimulus;GO:0034220|ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0017128|phospholipid scramblase activity;GO:0046983|protein dimerization activity;","K19498","ANO3, TMEM16C; anoctamin-3"]
["ENSG00000223764",16,18,9,10.3451736889147,7,4,6,2.93667688562329,1.55418453867847,0.0157727776453611,0.0400507287024387,"up","yes","LINC02593","lincRNA","chr1:916865-921016:-","gi|21756535|dbj|BAC04900.1|",746,4e-88,"unnamed protein product [Homo sapiens]","gi|551894942|tpe|HG491573.1|",4152,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473217.1 (RP11-54O7.3 gene), lincRNA",".",".",".",".",".",".",".",".","pfam10577","UPF0560","Uncharacterized protein family UPF0560. This family of proteins has no known function.",".",".",".",".","."]
["ENSG00000140465",531,538,491,375.276631397397,154,209,274,2.93411505828224,1.55292544591196,4.55758382761933e-46,1.21418061971162e-44,"up","yes","CYP1A1","protein_coding","chr15:74719542-74725610:-","gi|4503199|ref|NP_000490.1|",2759,0,"cytochrome P450 1A1 isoform 1 [Homo sapiens]","gi|984655764|ref|NM_001319217.1|",2685,0,"Homo sapiens cytochrome P450 family 1 subfamily A member 1 (CYP1A1), transcript variant 3, mRNA","P04798",1067,0,"Cytochrome P450 1A1","BH0579",113,1e-25,"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0042904|9-cis-retinoic acid biosynthetic process;GO:0007568|aging;GO:0009308|amine metabolic process;GO:0043010|camera-type eye development;GO:0008283|cell proliferation;GO:0071280|cellular response to copper ion;GO:0071407|cellular response to organic cyclic compound;GO:0009804|coumarin metabolic process;GO:0019341|dibenzo-p-dioxin catabolic process;GO:0048565|digestive tract development;GO:0017144|drug metabolic process;GO:0019373|epoxygenase P450 pathway;GO:0009692|ethylene metabolic process;GO:0009812|flavonoid metabolic process;GO:0070365|hepatocyte differentiation;GO:0050665|hydrogen peroxide biosynthetic process;GO:0017143|insecticide metabolic process;GO:0002933|lipid hydroxylation;GO:0042759|long-chain fatty acid biosynthetic process;GO:0060137|maternal process involved in parturition;GO:0097267|omega-hydroxylase P450 pathway;GO:0055114|oxidation-reduction process;GO:0006778|porphyrin-containing compound metabolic process;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:0019216|regulation of lipid metabolic process;GO:0046677|response to antibiotic;GO:0046685|response to arsenic-containing substance;GO:0042493|response to drug;GO:0032094|response to food;GO:0009635|response to herbicide;GO:0055093|response to hyperoxia;GO:0001666|response to hypoxia;GO:0035902|response to immobilization stress;GO:0010041|response to iron(III) ion;GO:0032496|response to lipopolysaccharide;GO:0009624|response to nematode;GO:0009615|response to virus;GO:0033189|response to vitamin A;GO:0009611|response to wounding;GO:0008202|steroid metabolic process;GO:0042359|vitamin D metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0031090|organelle membrane;","GO:0070330|aromatase activity;GO:0032451|demethylase activity;GO:0019899|enzyme binding;GO:0016711|flavonoid 3'-monooxygenase activity;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016491|oxidoreductase activity;GO:0016679|oxidoreductase activity, acting on diphenols and related substances as donors;GO:0019825|oxygen binding;GO:0070576|vitamin D 24-hydroxylase activity;","K07408","CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 [EC:1.14.14.1]"]
["ENSG00000122367",12,24,16,12.6888227855007,6,10,5,2.90811218713951,1.54008292562198,0.0096660834290186,0.0257513007153192,"up","yes","LDB3","protein_coding","chr10:86668449-86736068:+","gi|284413714|ref|NP_001165081.1|",3287,0,"LIM domain-binding protein 3 isoform 5 [Homo sapiens]","gi|284413713|ref|NM_001171610.1|",5436,0,"Homo sapiens LIM domain binding 3 (LDB3), transcript variant 5, mRNA","O75112",608,0,"LIM domain-binding protein 3",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0045214|sarcomere organization;","GO:0005856|cytoskeleton;GO:0048471|perinuclear region of cytoplasm;GO:0031143|pseudopodium;GO:0030018|Z disc;","GO:0008092|cytoskeletal protein binding;GO:0046872|metal ion binding;GO:0051371|muscle alpha-actinin binding;GO:0005080|protein kinase C binding;",".","."]
["ENSG00000145107",264,210,194,160.868700943947,83,77,113,2.89517146464895,1.53364879342121,1.03334195457938e-19,1.22025352896808e-18,"up","yes","TM4SF19","protein_coding","chr3:196319342-196338503:-","gi|694905772|ref|XP_009445351.1|",1033,4e-134,"PREDICTED: transmembrane 4 L6 family member 19 isoform X1 [Pan troglodytes]","gi|694905771|ref|XM_009447076.1|",1537,0,"PREDICTED: Pan troglodytes transmembrane 4 L six family member 19 (TM4SF19), transcript variant X1, mRNA","Q96DZ7",190,7e-63,"Transmembrane 4 L6 family member 19",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000069431",61,47,41,35.9515528414047,23,15,22,2.89496144926166,1.53354413670179,1.26015879260586e-05,5.44244128790457e-05,"up","yes","ABCC9","protein_coding","chr12:21797401-21942529:-","gi|110832837|ref|NP_064693.2|",7757,0,"ATP-binding cassette sub-family C member 9 isoform SUR2B [Homo sapiens]","gi|767971626|ref|XM_011520545.1|",8293,0,"PREDICTED: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant X3, mRNA","O60706",2922,0,"ATP-binding cassette sub-family C member 9","YDR135c",613,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0051607|defense response to virus;GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0042493|response to drug;GO:0055085|transmembrane transport;","GO:0008282|ATP-sensitive potassium channel complex;GO:0005886|plasma membrane;GO:0042383|sarcolemma;GO:0030017|sarcomere;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0044325|ion channel binding;GO:0005267|potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0008281|sulfonylurea receptor activity;GO:0005215|transporter activity;","K05033","ABCC9, SUR2; ATP-binding cassette subfamily C (CFTR/MRP) member 9"]
["ENSG00000091106",16,17,19,12.5489472049465,4,6,12,2.89321364192633,1.53267285930882,0.00770248783838501,0.021002457774295,"up","yes","NLRC4","protein_coding","chr2:32224453-32265854:-","gi|40788015|ref|NP_067032.3|",5328,0,"NLR family CARD domain-containing protein 4 isoform a [Homo sapiens]","gi|14040074|gb|AF376061.1|AF376061",3566,0,"Homo sapiens caspase recruitment domain protein 12 mRNA, complete cds","Q9NPP4",2056,0,"NLR family CARD domain-containing protein 4",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0002218|activation of innate immune response;GO:0042742|defense response to bacterium;GO:0016045|detection of bacterium;GO:0006954|inflammatory response;GO:1990001|inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045087|innate immune response;GO:0050702|interleukin-1 beta secretion;GO:0043065|positive regulation of apoptotic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;GO:0070269|pyroptosis;GO:0042981|regulation of apoptotic process;GO:0009966|regulation of signal transduction;","GO:0005829|cytosol;GO:0005622|intracellular;GO:0072557|IPAF inflammasome complex;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0042803|protein homodimerization activity;GO:0004842|ubiquitin-protein transferase activity;","K12805","NLRC4, CARD12; NLR family CARD domain-containing protein 4"]
["ENSG00000259518",71,65,44,43.3313180955989,22,26,25,2.89272587138439,1.53242961302462,1.33478551796353e-06,6.40909710492424e-06,"up","yes","LINC01583","lincRNA","chr15:82088594-82097694:+","gi|989984437|ref|XP_015450093.1|",145,9e-07,"PREDICTED: general transcription factor II-I isoform X2 [Pteropus alecto]","gi|629266082|ref|NR_120367.1|",2568,0,"Homo sapiens long intergenic non-protein coding RNA 1583 (LINC01583), long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000157150",300,296,291,214.209677336521,79,120,173,2.88084287477595,1.52649097602599,9.476235495361e-25,1.37426789650017e-23,"up","yes","TIMP4","protein_coding","chr3:12153051-12159351:-","gi|675730422|ref|XP_002758684.2|",1233,3e-164,"PREDICTED: metalloproteinase inhibitor 4 [Callithrix jacchus]","gi|319890247|ref|NM_003256.3|",1633,0,"Homo sapiens TIMP metallopeptidase inhibitor 4 (TIMP4), mRNA","Q99727",429,6e-147,"Metalloproteinase inhibitor 4",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0007417|central nervous system development;GO:0043086|negative regulation of catalytic activity;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0007219|Notch signaling pathway;GO:0042698|ovulation cycle;GO:0034097|response to cytokine;GO:0042493|response to drug;GO:0009725|response to hormone;GO:0032496|response to lipopolysaccharide;GO:0043434|response to peptide hormone;","GO:0005615|extracellular space;GO:0030017|sarcomere;","GO:0046872|metal ion binding;GO:0008191|metalloendopeptidase inhibitor activity;GO:0002020|protease binding;",".","."]
["ENSG00000019549",248,281,208,178.269864432859,77,112,116,2.87345671913132,1.52278731903069,7.29350243808107e-21,9.0119843065796e-20,"up","yes","SNAI2","protein_coding","chr8:48917604-48921740:-","gi|11276067|ref|NP_003059.1|",962,4e-119,"zinc finger protein SNAI2 [Homo sapiens]","gi|237858785|ref|NG_012130.1|",2577,0,"Homo sapiens snail family zinc finger 2 (SNAI2), RefSeqGene on chromosome 8","O43623",375,1e-120,"Zinc finger protein SNAI2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0060070|canonical Wnt signaling pathway;GO:0003273|cell migration involved in endocardial cushion formation;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0035921|desmosome disassembly;GO:0001837|epithelial to mesenchymal transition;GO:0003198|epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0060429|epithelium development;GO:2000811|negative regulation of anoikis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:1900387|negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter;GO:0032331|negative regulation of chondrocyte differentiation;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010839|negative regulation of keratinocyte proliferation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0010957|negative regulation of vitamin D biosynthetic process;GO:0070563|negative regulation of vitamin D receptor signaling pathway;GO:0014032|neural crest cell development;GO:0007219|Notch signaling pathway;GO:0001649|osteoblast differentiation;GO:0043473|pigmentation;GO:0030335|positive regulation of cell migration;GO:2000810|regulation of bicellular tight junction assembly;GO:0032642|regulation of chemokine production;GO:0045667|regulation of osteoblast differentiation;GO:0007605|sensory perception of sound;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K05706","SNAI2, SLUG; snail 2"]
["ENSG00000140403",17,18,19,13.2115898129561,8,8,6,2.86428033174522,1.51817269840759,0.00672630545314163,0.0186029509005156,"up","yes","DNAJA4","protein_coding","chr15:78264086-78282196:+","gi|194328758|ref|NP_061072.3|",1973,0,"dnaJ homolog subfamily A member 4 isoform 1 [Homo sapiens]","gi|194328757|ref|NM_018602.3|",3186,0,"Homo sapiens DnaJ heat shock protein family (Hsp40) member A4 (DNAJA4), transcript variant 1, mRNA","Q8WW22",709,0,"DnaJ homolog subfamily A member 4","YNL064c",287,9e-86,"COG0484","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0090084|negative regulation of inclusion body assembly;GO:0042026|protein refolding;GO:0009408|response to heat;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0051087|chaperone binding;GO:0031072|heat shock protein binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;","K09505","DNAJA4; DnaJ homolog subfamily A member 4"]
["ENSG00000163659",2721,2481,2528,1875.28384978025,901,992,1331,2.854439363774,1.51320741580596,5.82459454111852e-164,7.59086348034419e-162,"up","yes","TIPARP","protein_coding","chr3:156673235-156706770:+","gi|544412217|ref|XP_005546237.1|",3621,0,"PREDICTED: TCDD-inducible poly [ADP-ribose] polymerase isoform X1 [Macaca fascicularis]","gi|296080687|ref|NM_001184717.1|",4100,0,"Homo sapiens TCDD-inducible poly(ADP-ribose) polymerase (TIPARP), transcript variant 1, mRNA","Q7Z3E1",1380,0,"TCDD-inducible poly [ADP-ribose] polymerase",".",".",".",".","pfam00644","PARP","Poly(ADP-ribose) polymerase catalytic domain. Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.","GO:0008209|androgen metabolic process;GO:0071407|cellular response to organic cyclic compound;GO:0008210|estrogen metabolic process;GO:0060325|face morphogenesis;GO:0008585|female gonad development;GO:0030097|hemopoiesis;GO:0001822|kidney development;GO:0010629|negative regulation of gene expression;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0045732|positive regulation of protein catabolic process;GO:0009791|post-embryonic development;GO:0006471|protein ADP-ribosylation;GO:0060021|palate development;GO:0048705|skeletal system morphogenesis;GO:0048745|smooth muscle tissue development;GO:0001570|vasculogenesis;","GO:0005634|nucleus;","GO:0035326|enhancer binding;GO:0046872|metal ion binding;GO:0003950|NAD+ ADP-ribosyltransferase activity;","K15259","PARP7S; poly [ADP-ribose] polymerase 7/11/12/13 [EC:2.4.2.30]"]
["ENSG00000271933",24,25,31,19.4524092832385,7,11,16,2.85381677796555,1.51289271322793,0.00106506262093708,0.00346642543493287,"up","yes","AL603756.1","antisense","chr10:84138420-84140582:-","gi|355756662|gb|EHH60270.1|",286,8e-27,"hypothetical protein EGM_11598, partial [Macaca fascicularis]","gi|551869302|tpe|HG503093.1|",2163,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000470945.1 (RP11-338I21.1 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000154263",28,16,21,15.5982874004709,7,2,19,2.85161212770863,1.51177776176558,0.00825834556328766,0.0223717653405467,"up","yes","ABCA10","protein_coding","chr17:69147214-69244846:-","gi|153792144|ref|NP_525021.3|",7993,0,"ATP-binding cassette sub-family A member 10 [Homo sapiens]","gi|153792143|ref|NM_080282.3|",6331,0,"Homo sapiens ATP binding cassette subfamily A member 10 (ABCA10), mRNA","Q8WWZ4",3083,0,"ATP-binding cassette sub-family A member 10","PH0913",145,3e-36,"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;","GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05652","ABCA10; ATP-binding cassette, subfamily A (ABC1), member 10"]
["ENSG00000181409",23,19,10,12.6472496786917,12,6,2,2.84102974029902,1.50641393394116,0.0201802282948713,0.0495716051135351,"up","yes","AATK","protein_coding","chr17:81117295-81166077:-","gi|187937179|ref|NP_001073864.2|",5420,0,"serine/threonine-protein kinase LMTK1 isoform 1 [Homo sapiens]","gi|187937178|ref|NM_001080395.2|",5257,0,"Homo sapiens apoptosis-associated tyrosine kinase (AATK), transcript variant 1, mRNA","Q6ZMQ8",2092,0,"Serine/threonine-protein kinase LMTK1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.",".","GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K17480","AATK, LMTK1; lemur tyrosine kinase 1 [EC:2.7.10.1]"]
["ENSG00000272138",15,22,22,14.4336642073512,5,11,9,2.83694293576442,1.50433713153661,0.00546200625072277,0.0154179974482571,"up","yes","LINC01607","lincRNA","chr8:79768142-79802842:+","gi|119607473|gb|EAW87067.1|",351,3e-39,"hCG2039868, partial [Homo sapiens]","gi|668259761|ref|NR_125410.1|",621,0,"Homo sapiens long intergenic non-protein coding RNA 1607 (LINC01607), long non-coding RNA",".",".",".",".",".",".",".",".","pfam14768","RPA_interact_C","Replication protein A interacting C-terminal. This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.",".",".",".",".","."]
["ENSG00000188732",162,140,127,103.660763921221,42,54,86,2.83317284763375,1.50241862106552,2.00719260411564e-13,1.69801451527116e-12,"up","yes","FAM221A","protein_coding","chr7:23680130-23703249:+","gi|119614210|gb|EAW93804.1|",1507,0,"hypothetical protein MGC72075, isoform CRA_g [Homo sapiens]","gi|21732670|emb|AL832127.1|",4113,0,"Homo sapiens mRNA; cDNA DKFZp686F0810 (from clone DKFZp686F0810)",".",".",".",".",".",".",".",".","pfam14753","DUF4475","Domain of unknown function (DUF4475). This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.",".",".",".",".","."]
["ENSG00000117480",20,19,16,13.3454904848404,5,11,7,2.82936749487454,1.50047957461325,0.00698114288060727,0.0192361196399307,"up","yes","FAAH","protein_coding","chr1:46394265-46413848:+","gi|2149156|gb|AAB58505.1|",2533,0,"fatty acid amide hydrolase [Homo sapiens]","gi|166795286|ref|NM_001441.2|",2089,0,"Homo sapiens fatty acid amide hydrolase (FAAH), mRNA","O00519",979,0,"Fatty-acid amide hydrolase 1","SPCC550.07",135,1e-32,"COG0154","pfam01425","Amidase","Amidase.","GO:0019369|arachidonic acid metabolic process;GO:0009062|fatty acid catabolic process;","GO:0005856|cytoskeleton;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031090|organelle membrane;","GO:0047372|acylglycerol lipase activity;GO:0004040|amidase activity;GO:0017064|fatty acid amide hydrolase activity;","K15528","FAAH; fatty acid amide hydrolase [EC:3.5.1.99]"]
["ENSG00000100197",27,15,19,14.8284884591654,10,7,8,2.82560771634937,1.49856118790783,0.00528680752185277,0.0149627629640005,"up","yes","CYP2D6","protein_coding","chr22:42126499-42130906:-","gi|392513721|ref|NP_000097.3|",2305,0,"cytochrome P450 2D6 isoform 1 [Homo sapiens]","gi|62088563|dbj|AB209492.1|",2226,0,"Homo sapiens premature mRNA for debrisoquine 4-hydroxylase mutant allele variant","P10635",894,0,"Cytochrome P450 2D6","alr1450",104,8e-23,"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0009822|alkaloid catabolic process;GO:0009820|alkaloid metabolic process;GO:0019369|arachidonic acid metabolic process;GO:0009804|coumarin metabolic process;GO:0042737|drug catabolic process;GO:0017144|drug metabolic process;GO:0046483|heterocycle metabolic process;GO:0033076|isoquinoline alkaloid metabolic process;GO:0042759|long-chain fatty acid biosynthetic process;GO:0016098|monoterpenoid metabolic process;GO:0051100|negative regulation of binding;GO:0090350|negative regulation of cellular organofluorine metabolic process;GO:0055114|oxidation-reduction process;GO:0070989|oxidative demethylation;GO:0008202|steroid metabolic process;GO:0006805|xenobiotic metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005739|mitochondrion;GO:0031090|organelle membrane;","GO:0070330|aromatase activity;GO:0008144|drug binding;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016491|oxidoreductase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395|steroid hydroxylase activity;","K17712","CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 [EC:1.14.14.1]"]
["ENSG00000225377",127,103,94,78.5302565079815,42,35,59,2.82415970051787,1.49782167240185,2.16004211186497e-10,1.48424981309767e-09,"up","yes","NRSN2-AS1","antisense","chr20:320313-348224:-","gi|426390683|ref|XP_004061729.1|",294,2e-29,"PREDICTED: uncharacterized protein LOC101131837 [Gorilla gorilla gorilla]","gi|551890283|tpe|HG511124.1|",762,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000077437.1 (RP5-1103G7.4 gene), antisense",".",".",".",".",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSG00000105808",27,7,20,12.999775066493,5,7,11,2.81979071743501,1.49558809094928,0.0131896652013312,0.0341617110787266,"up","yes","RASA4","protein_coding","chr7:102573807-102616757:-","gi|299829177|ref|NP_008920.5|",4212,0,"ras GTPase-activating protein 4 isoform 1 [Homo sapiens]","gi|299829176|ref|NM_006989.5|",5605,0,"Homo sapiens RAS p21 protein activator 4 (RASA4), transcript variant 1, mRNA","O43374",1627,0,"Ras GTPase-activating protein 4",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0071277|cellular response to calcium ion;GO:0000165|MAPK cascade;GO:0034260|negative regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;","GO:0005829|cytosol;GO:0031235|intrinsic component of the cytoplasmic side of the plasma membrane;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0005543|phospholipid binding;","K17630","RASA4, CAPRI; Ras GTPase-activating protein 4"]
["ENSG00000010379",24,25,25,18.1479285144016,12,7,12,2.80721780363517,1.48914100258723,0.001919739197289,0.00596166956002418,"up","yes","SLC6A13","protein_coding","chr12:220621-262873:-","gi|530398785|ref|XP_005253806.1|",2878,0,"PREDICTED: sodium- and chloride-dependent GABA transporter 2 isoform X1 [Homo sapiens]","gi|343432608|ref|NM_016615.4|",2185,0,"Homo sapiens solute carrier family 6 member 13 (SLC6A13), transcript variant 1, mRNA","Q9NSD5",1110,0,"Sodium- and chloride-dependent GABA transporter 2","MJ1319",204,2e-56,"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.",".","GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0005332|gamma-aminobutyric acid:sodium symporter activity;GO:0005215|transporter activity;","K05039","SLC6A6S; solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13"]
["ENSG00000178809",17,26,21,15.6951734766759,5,16,6,2.80649207859188,1.48876798725555,0.00659005020371944,0.0182575248964867,"up","yes","TRIM73","protein_coding","chr7:75395063-75410996:+","gi|767947759|ref|XP_011514494.1|",456,2e-48,"PREDICTED: tripartite motif-containing protein 74 isoform X4 [Homo sapiens]","gi|34533185|dbj|AK126632.1|",3869,0,"Homo sapiens cDNA FLJ44673 fis, clone BRACE3007058","Q86UV7",178,4e-48,"Tripartite motif-containing protein 73",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;","GO:0008270|zinc ion binding;","K12024","TRIM50_73_74; tripartite motif-containing protein 50/73/74"]
["ENSG00000134107",5143,4965,4718,3610.57303492421,1629,2050,2635,2.8054491112548,1.48823174363808,4.4666382940357e-286,1.43587532358934e-283,"up","yes","BHLHE40","protein_coding","chr3:4979116-4985323:+","gi|4503299|ref|NP_003661.1|",2058,0,"class E basic helix-loop-helix protein 40 [Homo sapiens]","gi|197276631|ref|NM_003670.2|",3035,0,"Homo sapiens basic helix-loop-helix family member e40 (BHLHE40), mRNA","O14503",797,0,"Class E basic helix-loop-helix protein 40",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0032922|circadian regulation of gene expression;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005634|nucleus;","GO:0043425|bHLH transcription factor binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0070888|E-box binding;GO:0043426|MRF binding;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0001102|RNA polymerase II activating transcription factor binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001191|transcriptional repressor activity, RNA polymerase II transcription factor binding;","K03729","BHLHB2, DEC1; class B basic helix-loop-helix protein 2"]
["ENSG00000174482",17,25,14,13.6145777419784,5,9,10,2.80029675341722,1.48557972074094,0.00730395369871394,0.0200363329064417,"up","yes","LINGO2","protein_coding","chr9:27948078-28670286:-","gi|22749183|ref|NP_689783.1|",2886,0,"leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor [Homo sapiens]","gi|384871703|ref|NM_152570.2|",3033,0,"Homo sapiens leucine rich repeat and Ig domain containing 2 (LINGO2), transcript variant 1, mRNA","Q7L985",1116,0,"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000186496",13,18,12,10.5613241980145,7,5,6,2.79143430304307,1.48100660240542,0.0179049873628971,0.0446702852981392,"up","yes","ZNF396","protein_coding","chr18:35366697-35377337:-","gi|21955239|ref|NP_665699.1|",1785,0,"zinc finger protein 396 [Homo sapiens]","gi|222352103|ref|NM_145756.2|",2788,0,"Homo sapiens zinc finger protein 396 (ZNF396), mRNA","Q96N95",626,0,"Zinc finger protein 396",".",".",".",".","pfam02023","SCAN","SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.","GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09230","SCAN; SCAN domain-containing zinc finger protein"]
["ENSG00000059728",1282,1263,1147,902.203837906663,453,532,585,2.78241440405716,1.4763373063483,9.00097433625571e-87,4.93212480107103e-85,"up","yes","MXD1","protein_coding","chr2:69897688-69942945:+","gi|4505069|ref|NP_002348.1|",857,3e-101,"max dimerization protein 1 isoform 1 [Homo sapiens]","gi|321400049|ref|NM_002357.3|",5587,0,"Homo sapiens MAX dimerization protein 1 (MXD1), transcript variant 1, mRNA","Q05195",334,8e-103,"Max dimerization protein 1",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0008283|cell proliferation;GO:0007275|multicellular organismal development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003712|transcription cofactor activity;GO:0003714|transcription corepressor activity;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09114","MXD, MAD; MAX dimerization protein"]
["ENSG00000210082",169858,169510,155192,120824.703758663,53767,71439,88094,2.77642323286801,1.47322750646747,0,0,"up","yes","MT-RNR2","Mt_rRNA","chrMT:1671-3229:+","gi|345543|pir||JC1348",216,4e-17,"hypothetical 18K protein - goldfish mitochondrion","gi|992420031|gb|KJ937460.2|",1557,0,"Homo sapiens isolate triad1_B mitochondrion, complete genome","Q8IVG9",50.4,1e-06,"Humanin",".",".",".",".","pfam15040","Humanin","Humanin family. This family of proteins is found exclusively in humans. Humanin is a short anti-apoptotic peptide that interacts with Bax.","GO:0006915|apoptotic process;GO:0006879|cellular iron ion homeostasis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0030595|leukocyte chemotaxis;GO:0043066|negative regulation of apoptotic process;","GO:0005576|extracellular region;GO:0005739|mitochondrion;GO:0048471|perinuclear region of cytoplasm;","GO:0048019|receptor antagonist activity;GO:0005102|receptor binding;",".","."]
["ENSG00000001084",2716,2467,2593,1901.80314658832,919,1093,1321,2.77430471252829,1.47212625309436,6.60613707583047e-160,8.43835575619987e-158,"up","yes","GCLC","protein_coding","chr6:53497341-53616970:-","gi|4557625|ref|NP_001489.1|",3456,0,"glutamate--cysteine ligase catalytic subunit isoform a [Homo sapiens]","gi|308199421|ref|NM_001498.3|",3813,0,"Homo sapiens glutamate-cysteine ligase catalytic subunit (GCLC), transcript variant 1, mRNA","P48506",1335,0,"Glutamate--cysteine ligase catalytic subunit",".",".",".",".","pfam03074","GCS","Glutamate-cysteine ligase. This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS).  This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).","GO:0007568|aging;GO:0008637|apoptotic mitochondrial changes;GO:0045454|cell redox homeostasis;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071333|cellular response to glucose stimulus;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0032869|cellular response to insulin stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0097069|cellular response to thyroxine stimulus;GO:0006534|cysteine metabolic process;GO:0006536|glutamate metabolic process;GO:0006750|glutathione biosynthetic process;GO:0019852|L-ascorbic acid metabolic process;GO:0043066|negative regulation of apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2000490|negative regulation of hepatic stellate cell activation;GO:0043524|negative regulation of neuron apoptotic process;GO:0031397|negative regulation of protein ubiquitination;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0050880|regulation of blood vessel size;GO:0051900|regulation of mitochondrial depolarization;GO:0014823|response to activity;GO:0046685|response to arsenic-containing substance;GO:0046686|response to cadmium ion;GO:0009408|response to heat;GO:0009725|response to hormone;GO:0044752|response to human chorionic gonadotropin;GO:0070555|response to interleukin-1;GO:0051409|response to nitrosative stress;GO:0007584|response to nutrient;GO:0006979|response to oxidative stress;GO:0009410|response to xenobiotic stimulus;","GO:0005829|cytosol;GO:0017109|glutamate-cysteine ligase complex;","GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0050662|coenzyme binding;GO:0016595|glutamate binding;GO:0004357|glutamate-cysteine ligase activity;GO:0000287|magnesium ion binding;GO:0046982|protein heterodimerization activity;","K11204","GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]"]
["ENSG00000260267",33,21,17,17.1820989247255,8,12,10,2.77417878117348,1.47206076473477,0.00300645012590016,0.008979314033503,"up","yes","AC026471.1","antisense","chr16:31456711-31459736:-","gi|119572518|gb|EAW52133.1|",923,2e-105,"armadillo repeat containing 5, isoform CRA_c, partial [Homo sapiens]","gi|685844879|ref|NG_034258.1|",3026,0,"Homo sapiens armadillo repeat containing 5 (ARMC5), RefSeqGene on chromosome 16","Q8BPP0",95.5,3e-19,"Zinc finger protein 436",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000250091",37,28,30,23.0020852731258,8,9,25,2.77055573225862,1.47017538846162,0.000818337392162603,0.00271858277988844,"up","yes","DNAH10OS","antisense","chr12:123925461-123934984:-","gi|341958574|sp|P0CZ25.1|D10OS_HUMAN",812,7e-96,"RecName: Full=Uncharacterized protein DNAH10OS","gi|197107098|gb|AC208069.3|",5083,0,"Homo sapiens FOSMID clone ABC12-46796200N9 from chromosome 12, complete sequence",".",".",".",".",".",".",".",".","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.",".",".",".",".","."]
["ENSG00000140105",4650,4435,4186,3242.62427824247,1535,1825,2348,2.77040110996713,1.47009487066675,1.26780210331778e-277,4.00874868340874e-275,"up","yes","WARS","protein_coding","chr14:100333788-100376805:-","gi|47419914|ref|NP_004175.2|",2540,0,"tryptophan--tRNA ligase, cytoplasmic isoform a [Homo sapiens]","gi|675801151|ref|XM_003832857.2|",3023,0,"PREDICTED: Pan paniscus tryptophanyl-tRNA synthetase (WARS), transcript variant X1, mRNA","P23381",983,0,"Tryptophan--tRNA ligase, cytoplasmic","SPAC2F7.13c",478,4e-158,"COG0180","pfam00579","tRNA-synt_1b","tRNA synthetases class I (W and Y).","GO:0001525|angiogenesis;GO:0008285|negative regulation of cell proliferation;GO:0006469|negative regulation of protein kinase activity;GO:0001933|negative regulation of protein phosphorylation;GO:0010628|positive regulation of gene expression;GO:0031334|positive regulation of protein complex assembly;GO:0045765|regulation of angiogenesis;GO:0010835|regulation of protein ADP-ribosylation;GO:0006412|translation;GO:0006418|tRNA aminoacylation for protein translation;GO:0006436|tryptophanyl-tRNA aminoacylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0005524|ATP binding;GO:0019210|kinase inhibitor activity;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0004830|tryptophan-tRNA ligase activity;","K01867","WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"]
["ENSG00000154589",115,79,90,69.1126268283816,30,43,49,2.77031851616396,1.47005185904433,3.24296939819393e-09,2.00033238734776e-08,"up","yes","LY96","protein_coding","chr8:73991352-74029087:+","gi|296434574|sp|Q9Y6Y9.2|LY96_HUMAN",679,8e-88,"RecName: Full=Lymphocyte antigen 96; Short=Ly-96; AltName: Full=ESOP-1; AltName: Full=Protein MD-2; Flags: Precursor","gi|307775406|ref|NM_015364.4|",596,0,"Homo sapiens lymphocyte antigen 96 (LY96), transcript variant 1, mRNA","Q9Y6Y9",266,3e-89,"Lymphocyte antigen 96",".",".",".",".","pfam02221","E1_DerP2_DerF2","ML domain. ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.","GO:0097190|apoptotic signaling pathway;GO:0007166|cell surface receptor signaling pathway;GO:0006968|cellular defense response;GO:0032497|detection of lipopolysaccharide;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0002756|MyD88-independent toll-like receptor signaling pathway;GO:0070266|necroptotic process;GO:0034128|negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032496|response to lipopolysaccharide;GO:0034142|toll-like receptor 4 signaling pathway;GO:0002224|toll-like receptor signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;","GO:0010008|endosome membrane;GO:0005615|extracellular space;GO:0031226|intrinsic component of plasma membrane;GO:0046696|lipopolysaccharide receptor complex;GO:0005886|plasma membrane;","GO:0015026|coreceptor activity;GO:0001875|lipopolysaccharide receptor activity;","K05400","LY96, MD-2; lymphocyte antigen 96"]
["ENSG00000187801",304,213,222,179.743146460299,80,112,125,2.76748784486917,1.46857698053511,1.1700977538523e-19,1.37698874169024e-18,"up","yes","ZFP69B","protein_coding","chr1:40450102-40463718:+","gi|530363191|ref|XP_005271193.1|",2276,0,"PREDICTED: zinc finger protein ZFP69B isoform X2 [Homo sapiens]","gi|21750026|dbj|AK091612.1|",2375,0,"Homo sapiens cDNA FLJ34293 fis, clone FEBRA2004651, highly similar to Zinc finger protein 643","Q9UJL9",878,0,"Zinc finger protein ZFP69B",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000102265",5600,5499,5290,4009.71235098339,1859,2273,2951,2.76420646264564,1.46686537676482,9.892532923229e-277,3.07753508102001e-274,"up","yes","TIMP1","protein_coding","chrX:47582313-47586789:+","gi|194382220|dbj|BAG58865.1|",1259,2e-171,"unnamed protein product [Homo sapiens]","gi|164691592|dbj|AK310206.1|",1061,0,"Homo sapiens cDNA, FLJ17248","Q5RC60",197,1e-59,"Metalloproteinase inhibitor 1",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0043086|negative regulation of catalytic activity;GO:0010951|negative regulation of endopeptidase activity;GO:0008284|positive regulation of cell proliferation;GO:2001044|regulation of integrin-mediated signaling pathway;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0046872|metal ion binding;GO:0008191|metalloendopeptidase inhibitor activity;","K16451","TIMP1; metallopeptidase inhibitor 1"]
["ENSG00000232233",43,23,18,20.2115580110461,10,9,17,2.76276475413685,1.46611272375411,0.00197192455578181,0.00611585155682901,"up","yes","LINC02043","lincRNA","chr3:186810880-186825521:-","gi|34526647|dbj|BAC85254.1|",377,4e-61,"unnamed protein product [Homo sapiens]","gi|667751626|ref|NR_125409.1|",1832,0,"Homo sapiens uncharacterized LOC102724699 (LOC102724699), long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000186567",76,56,68,48.8314921078465,24,21,42,2.75631611211335,1.46274135510524,9.78495177291175e-07,4.77319549306833e-06,"up","yes","CEACAM19","protein_coding","chr19:44662278-44684359:+","gi|25482504|pir||T51879",662,1e-77,"hypothetical protein DKFZp547N157.1 - human (fragment)","gi|34535509|dbj|AK128234.1|",3247,0,"Homo sapiens cDNA FLJ46368 fis, clone TESTI4051504","Q7Z692",165,4e-43,"Carcinoembryonic antigen-related cell adhesion molecule 19",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".","K16825","CEACAM19, CEAL1; carcinoembryonic antigen-related cell adhesion molecule 19"]
["ENSG00000172164",774,716,628,517.921513314974,250,259,416,2.73649525172225,1.45232935322996,1.30083478518577e-46,3.50916102610672e-45,"up","yes","SNTB1","protein_coding","chr8:120535745-120813273:-","gi|821016984|ref|XP_003256210.2|",2665,0,"PREDICTED: beta-1-syntrophin [Nomascus leucogenys]","gi|208879457|ref|NM_021021.3|",4975,0,"Homo sapiens syntrophin beta 1 (SNTB1), mRNA","Q13884",966,0,"Beta-1-syntrophin",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0006936|muscle contraction;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016010|dystrophin-associated glycoprotein complex;GO:0005925|focal adhesion;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;GO:0045202|synapse;","GO:0003779|actin binding;GO:0005516|calmodulin binding;GO:0030165|PDZ domain binding;GO:0005198|structural molecule activity;",".","."]
["ENSG00000174586",22,24,17,15.4606355163145,7,13,7,2.73485810295222,1.4514659812892,0.00551426090720352,0.015551844476991,"up","yes","ZNF497","protein_coding","chr19:58354357-58362848:-","gi|119592983|gb|EAW72577.1|",2701,0,"zinc finger protein 497, isoform CRA_a [Homo sapiens]","gi|333033770|ref|NM_198458.2|",3468,0,"Homo sapiens zinc finger protein 497 (ZNF497), transcript variant 1, mRNA","Q6ZNH5",970,0,"Zinc finger protein 497",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000236453",27,20,25,17.7123026596139,11,8,12,2.73472150684844,1.4513939221784,0.00256430634408108,0.00775848482582523,"up","yes","AC003092.1","lincRNA","chr7:94022833-94066661:+","gi|119597205|gb|EAW76799.1|",136,2e-08,"hCG2045326 [Homo sapiens]","gi|551862223|tpe|HG500415.1|",743,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000341546.1 (AC003092.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam04080","Per1","Per1-like. PER1 is required for GPI-phospholipase A2 activity and is involved in lipid remodelling of GPI-anchored proteins.",".",".",".",".","."]
["ENSG00000112972",2762,2452,2333,1850.17485036828,925,1103,1241,2.73165241291773,1.44977392064755,1.22043115581622e-149,1.39288024457889e-147,"up","yes","HMGCS1","protein_coding","chr5:43289395-43313512:-","gi|33991031|gb|AAH00297.2|",2939,0,"HMGCS1 protein, partial [Homo sapiens]","gi|387763637|ref|NM_001098272.2|",3506,0,"Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), transcript variant 1, mRNA","Q01581",1086,0,"Hydroxymethylglutaryl-CoA synthase, cytoplasmic","YML126c",436,3e-139,"COG3425","pfam08540","HMG_CoA_synt_C","Hydroxymethylglutaryl-coenzyme A synthase C terminal.","GO:0007420|brain development;GO:0071397|cellular response to cholesterol;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0006695|cholesterol biosynthetic process;GO:0008299|isoprenoid biosynthetic process;GO:0006629|lipid metabolic process;GO:0001889|liver development;GO:0008584|male gonad development;GO:0045540|regulation of cholesterol biosynthetic process;GO:0019216|regulation of lipid metabolic process;GO:0042493|response to drug;GO:0009645|response to low light intensity stimulus;GO:0014074|response to purine-containing compound;GO:0046690|response to tellurium ion;GO:0033197|response to vitamin E;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0008144|drug binding;GO:0004421|hydroxymethylglutaryl-CoA synthase activity;GO:0016853|isomerase activity;GO:0043177|organic acid binding;GO:0042803|protein homodimerization activity;","K01641","E2.3.3.10; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]"]
["ENSG00000091482",14,15,15,10.8807126561389,7,5,7,2.72525383798058,1.44639061291352,0.0174076879487055,0.0436051279421599,"up","yes","SMPX","protein_coding","chrX:21705972-21758163:-","gi|10047090|ref|NP_055147.1|",442,2e-51,"small muscular protein [Homo sapiens]","gi|361050359|ref|NM_014332.2|",935,0,"Homo sapiens small muscle protein, X-linked (SMPX), transcript variant 1, mRNA","Q9UHP9",174,7e-53,"Small muscular protein",".",".",".",".","pfam15355","Chisel","Stretch-responsive small skeletal muscle X protein, Chisel. The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.","GO:0006941|striated muscle contraction;","GO:0043034|costamere;GO:0031430|M band;GO:0005927|muscle tendon junction;GO:0005634|nucleus;",".",".","."]
["ENSG00000139178",131,114,95,83.1616085140607,42,45,61,2.72484812896764,1.44617582266349,9.55107095633643e-11,6.76785659830335e-10,"up","yes","C1RL","protein_coding","chr12:7089587-7109273:-","gi|289547636|ref|NP_057630.2|",2532,0,"complement C1r subcomponent-like protein isoform 1 precursor [Homo sapiens]","gi|663071004|ref|NM_016546.3|",3394,0,"Homo sapiens complement C1r subcomponent like (C1RL), transcript variant 1, mRNA","Q9NZP8",978,0,"Complement C1r subcomponent-like protein","VC1649",61.2,1e-08,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSG00000168003",11538,11317,10733,8253.03013654855,3969,4723,6026,2.72013428869757,1.44367787679021,0,0,"up","yes","SLC3A2","protein_coding","chr11:62856102-62888875:+","gi|61744477|ref|NP_001012680.1|",2818,0,"4F2 cell-surface antigen heavy chain isoform b [Homo sapiens]","gi|312032446|ref|NM_001012662.2|",2222,0,"Homo sapiens solute carrier family 3 member 2 (SLC3A2), transcript variant 2, mRNA","P08195",1021,0,"4F2 cell-surface antigen heavy chain","DR1375",80.9,5e-15,"COG0366","pfam00128","Alpha-amylase","Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.","GO:0006865|amino acid transport;GO:0006816|calcium ion transport;GO:0005975|carbohydrate metabolic process;GO:0016049|cell growth;GO:1903801|L-leucine import into cell;GO:0050900|leukocyte migration;GO:0043330|response to exogenous dsRNA;GO:0015827|tryptophan transport;","GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0042470|melanosome;GO:0016020|membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;GO:0005432|calcium:sodium antiporter activity;GO:0003824|catalytic activity;GO:0003725|double-stranded RNA binding;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0003723|RNA binding;","K06519","SLC3A2, MDU1; solute carrier family 3, member 2"]
["ENSG00000186340",23,15,18,13.6431065398541,5,7,13,2.71243122814052,1.4395865594637,0.00857350375190715,0.0231313107241272,"up","yes","THBS2","protein_coding","chr6:169215780-169254044:-","gi|40317628|ref|NP_003238.2|",5681,0,"thrombospondin-2 precursor [Homo sapiens]","gi|538918410|ref|NM_003247.3|",5808,0,"Homo sapiens thrombospondin 2 (THBS2), mRNA","P35442",2194,0,"Thrombospondin-2",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0016525|negative regulation of angiogenesis;GO:0051965|positive regulation of synapse assembly;","GO:0005604|basement membrane;GO:0005576|extracellular region;GO:0031091|platelet alpha granule;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSG00000065833",2241,2191,2044,1592.82361618903,765,977,1097,2.71043335060493,1.43852353157449,2.0201119857525e-143,2.16466222117746e-141,"up","yes","ME1","protein_coding","chr6:83210389-83431071:-","gi|672886249|pdb|3WJA|A",2957,0,"Chain A, The Crystal Structure Of Human Cytosolic Nadp(+)-dependent Malic Enzyme In Apo Form","gi|574957071|ref|NM_002395.5|",3371,0,"Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic (ME1), mRNA","P48163",1143,0,"NADP-dependent malic enzyme","VC1188",423,2e-133,"COG0281","pfam03949","Malic_M","Malic enzyme, NAD binding domain.","GO:0005975|carbohydrate metabolic process;GO:0006108|malate metabolic process;GO:0006741|NADP biosynthetic process;GO:0051262|protein tetramerization;GO:0006090|pyruvate metabolic process;GO:0019216|regulation of lipid metabolic process;GO:1902031|regulation of NADP metabolic process;GO:0009743|response to carbohydrate;GO:0009725|response to hormone;","GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0043531|ADP binding;GO:0009055|electron carrier activity;GO:0004471|malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473|malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0004470|malic enzyme activity;GO:0030145|manganese ion binding;GO:0051287|NAD binding;GO:0050661|NADP binding;GO:0008948|oxaloacetate decarboxylase activity;","K00029","E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]"]
["ENSG00000130768",30,17,10,13.7154138671141,4,11,10,2.71012104951232,1.43835729203336,0.0126831078154822,0.0329781320497467,"up","yes","SMPDL3B","protein_coding","chr1:27934993-27959157:+","gi|767903803|ref|XP_011539562.1|",1894,0,"PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b isoform X2 [Homo sapiens]","gi|752507679|ref|NM_001304579.1|",1913,0,"Homo sapiens sphingomyelin phosphodiesterase acid like 3B (SMPDL3B), transcript variant 3, mRNA","Q92485",731,0,"Acid sphingomyelinase-like phosphodiesterase 3b",".",".",".",".","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0046466|membrane lipid catabolic process;GO:0050728|negative regulation of inflammatory response;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0006685|sphingomyelin catabolic process;","GO:0031225|anchored component of membrane;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005886|plasma membrane;","GO:0016798|hydrolase activity, acting on glycosyl bonds;GO:0046872|metal ion binding;GO:0008081|phosphoric diester hydrolase activity;GO:0004767|sphingomyelin phosphodiesterase activity;","K01128","SMPDL3; sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-]"]
["ENSG00000160862",50,34,41,30.7346849571783,15,24,15,2.71009465387865,1.43834324061848,0.00014089144578643,0.000526650039986175,"up","yes","AZGP1","protein_coding","chr7:99966720-99976157:-","gi|114614917|ref|XP_001143820.1|",1042,1e-133,"PREDICTED: zinc-alpha-2-glycoprotein [Pan troglodytes]","gi|46255706|gb|BC014470.1|",2024,0,"Homo sapiens alpha-2-glycoprotein 1, zinc-binding, mRNA (cDNA clone IMAGE:4866070), with apparent retained intron","P25311",405,9e-135,"Zinc-alpha-2-glycoprotein",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0007155|cell adhesion;GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0008285|negative regulation of cell proliferation;GO:0001895|retina homeostasis;GO:0055085|transmembrane transport;","GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0008320|protein transmembrane transporter activity;GO:0004540|ribonuclease activity;",".","."]
["ENSG00000101670",2066,1912,1775,1412.73165747636,679,804,1046,2.70940481656271,1.43797596504791,2.98139705930639e-137,2.97954334092755e-135,"up","yes","LIPG","protein_coding","chr18:49560699-49599182:+","gi|5174497|ref|NP_006024.1|",2716,0,"endothelial lipase isoform 1 precursor [Homo sapiens]","gi|24111058|gb|AC091170.15|",8685,0,"Homo sapiens chromosome 18, clone RP11-879D5, complete sequence","Q9Y5X9",1050,0,"Endothelial lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0008283|cell proliferation;GO:0042632|cholesterol homeostasis;GO:0034375|high-density lipoprotein particle remodeling;GO:0006629|lipid metabolic process;GO:0009395|phospholipid catabolic process;GO:0055091|phospholipid homeostasis;GO:0032376|positive regulation of cholesterol transport;GO:0010983|positive regulation of high-density lipoprotein particle clearance;GO:0050746|regulation of lipoprotein metabolic process;GO:0007584|response to nutrient;GO:0043691|reverse cholesterol transport;","GO:0009986|cell surface;GO:0005769|early endosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;","GO:0008201|heparin binding;GO:0004465|lipoprotein lipase activity;GO:0008970|phosphatidylcholine 1-acylhydrolase activity;GO:0004620|phospholipase activity;",".","."]
["ENSG00000049249",47,59,80,46.1284152881217,16,30,38,2.70293124632582,1.43452481492614,1.11771059405356e-05,4.86535814446064e-05,"up","yes","TNFRSF9","protein_coding","chr1:7915894-7943165:-","gi|5730095|ref|NP_001552.2|",1153,3e-141,"tumor necrosis factor receptor superfamily member 9 precursor [Homo sapiens]","gi|315259099|ref|NM_001561.5|",5970,0,"Homo sapiens tumor necrosis factor receptor superfamily member 9 (TNFRSF9), mRNA","Q07011",448,1e-142,"Tumor necrosis factor receptor superfamily member 9",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006915|apoptotic process;GO:0097190|apoptotic signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0007275|multicellular organismal development;GO:0008285|negative regulation of cell proliferation;GO:2001180|negative regulation of interleukin-10 secretion;GO:2001183|negative regulation of interleukin-12 secretion;GO:0070207|protein homotrimerization;GO:0042981|regulation of apoptotic process;GO:0042127|regulation of cell proliferation;GO:0032496|response to lipopolysaccharide;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0019955|cytokine binding;GO:0038023|signaling receptor activity;GO:0005031|tumor necrosis factor-activated receptor activity;","K05146","TNFRSF9, CD137; tumor necrosis factor receptor superfamily member 9"]
["ENSG00000015285",24,19,13,13.5868434811378,5,7,13,2.70244036238975,1.4342627808336,0.00941828033288586,0.0251397441268617,"up","yes","WAS","protein_coding","chrX:48676596-48691427:+","gi|12804207|gb|AAH02961.1|",1475,0,"WAS protein, partial [Homo sapiens]","gi|187608471|ref|NM_000377.2|",1831,0,"Homo sapiens Wiskott-Aldrich syndrome (WAS), mRNA","P42768",558,0,"Wiskott-Aldrich syndrome protein",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0030041|actin filament polymerization;GO:0030048|actin filament-based movement;GO:0008154|actin polymerization or depolymerization;GO:0007596|blood coagulation;GO:0032488|Cdc42 protein signal transduction;GO:0071346|cellular response to interferon-gamma;GO:0006952|defense response;GO:0016197|endosomal transport;GO:0008544|epidermis development;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955|immune response;GO:2000146|negative regulation of cell motility;GO:0051497|negative regulation of stress fiber assembly;GO:2000601|positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0065003|macromolecular complex assembly;GO:0008064|regulation of actin polymerization or depolymerization;GO:0010591|regulation of lamellipodium assembly;GO:0051492|regulation of stress fiber assembly;GO:0002625|regulation of T cell antigen processing and presentation;GO:0042110|T cell activation;GO:0050852|T cell receptor signaling pathway;","GO:0015629|actin cytoskeleton;GO:0005884|actin filament;GO:0005911|cell-cell junction;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0045335|phagocytic vesicle;GO:0012506|vesicle membrane;","GO:0003779|actin binding;GO:0030695|GTPase regulator activity;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;GO:0019901|protein kinase binding;GO:0048365|Rac GTPase binding;GO:0017124|SH3 domain binding;GO:0031267|small GTPase binding;","K05747","WAS; Wiskott-Aldrich syndrome protein"]
["ENSG00000161010",1556,1295,1307,1023.24996511832,498,640,695,2.6877673935251,1.42640828888736,1.99217740328277e-87,1.10100623938447e-85,"up","yes","MRNIP","protein_coding","chr5:179835133-179862173:-","gi|33877106|gb|AAH02739.2|",839,4e-100,"C5orf45 protein, partial [Homo sapiens]","gi|34366403|emb|BX647375.1|",4094,0,"Homo sapiens mRNA; cDNA DKFZp686B0310 (from clone DKFZp686B0310)","Q6NTE8",332,3e-101,"MRN complex-interacting protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006974|cellular response to DNA damage stimulus;GO:0006281|DNA repair;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0045860|positive regulation of protein kinase activity;GO:0071168|protein localization to chromatin;GO:2001032|regulation of double-strand break repair via nonhomologous end joining;GO:0010212|response to ionizing radiation;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;",".","."]
["ENSG00000073849",312,300,290,222.2260546783,96,147,158,2.68514824236448,1.42500173909349,6.51134744353333e-25,9.52889753344999e-24,"up","yes","ST6GAL1","protein_coding","chr3:186930485-187078553:+","gi|27765093|ref|NP_775324.1|",748,2e-87,"beta-galactoside alpha-2,6-sialyltransferase 1 isoform b [Homo sapiens]","gi|34536250|dbj|AK128726.1|",4890,0,"Homo sapiens cDNA FLJ46893 fis, clone UTERU3019230, highly  similar to CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase (EC 2.4.99.1)","P15907",298,2e-87,"Beta-galactoside alpha-2,6-sialyltransferase 1",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006959|humoral immune response;GO:0006054|N-acetylneuraminate metabolic process;GO:0016266|O-glycan processing;GO:0009311|oligosaccharide metabolic process;GO:0018279|protein N-linked glycosylation via asparagine;GO:0097503|sialylation;","GO:0005576|extracellular region;GO:0032580|Golgi cisterna membrane;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0003835|beta-galactoside alpha-2,6-sialyltransferase activity;GO:0008373|sialyltransferase activity;","K00778","SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]"]
["ENSG00000174808",32,48,41,29.9129312875638,12,15,28,2.67942515993096,1.42192352013417,0.000205026958391857,0.000747553870219685,"up","yes","BTC","protein_coding","chr4:74744759-74794686:-","gi|332233210|ref|XP_003265796.1|",736,1e-87,"PREDICTED: probetacellulin [Nomascus leucogenys]","gi|948284405|ref|NM_001729.3|",2816,0,"Homo sapiens betacellulin (BTC), transcript variant 1, mRNA","P35070",286,1e-88,"Probetacellulin",".",".",".",".","pfam13584","BatD","Oxygen tolerance. This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.","GO:0007173|epidermal growth factor receptor signaling pathway;GO:0038128|ERBB2 signaling pathway;GO:0000165|MAPK cascade;GO:0043066|negative regulation of apoptotic process;GO:0045597|positive regulation of cell differentiation;GO:0051781|positive regulation of cell division;GO:0008284|positive regulation of cell proliferation;GO:0048146|positive regulation of fibroblast proliferation;GO:0045840|positive regulation of mitotic nuclear division;GO:0051897|positive regulation of protein kinase B signaling;GO:0035810|positive regulation of urine volume;GO:2000145|regulation of cell motility;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K09783","BTC; betacellulin"]
["ENSG00000248508",26,23,26,18.4419768890557,6,12,16,2.67472946726695,1.41939297900173,0.0024745682500718,0.00751408570645227,"up","yes","SRP14-AS1","lincRNA","chr15:40039311-40067290:+","gi|355755615|gb|EHH59362.1|",213,2e-31,"hypothetical protein EGM_09449, partial [Macaca fascicularis]","gi|551879198|tpe|HG506910.1|",2317,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000418269.1 (RP11-521C20.4 gene), lincRNA","Q6UX73",77,9e-24,"UPF0764 protein C16orf89",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000185640",20,11,17,11.7289379903483,4,5,13,2.67283517345039,1.41837087320477,0.0187263649219159,0.0464080851360547,"up","yes","KRT79","protein_coding","chr12:52821410-52834295:-","gi|54035279|gb|AAH39148.1|",2291,0,"Keratin 79 [Homo sapiens]","gi|39753955|ref|NM_175834.2|",2066,0,"Homo sapiens keratin 79 (KRT79), mRNA","Q5XKE5",886,0,"Keratin, type II cytoskeletal 79",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0070268|cornification;GO:0031424|keratinization;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0045095|keratin filament;","GO:0019899|enzyme binding;GO:0005198|structural molecule activity;","K07605","KRT2; type II keratin, basic"]
["ENSG00000064547",94,96,90,69.2228512721074,34,41,50,2.66728009570658,1.41536933275119,3.77292569614049e-09,2.30803015626888e-08,"up","yes","LPAR2","protein_coding","chr19:19623668-19628930:-","gi|795076544|ref|XP_011846277.1|",1616,0,"PREDICTED: lysophosphatidic acid receptor 2 [Mandrillus leucophaeus]","gi|34528497|dbj|AK123043.1|",2525,0,"Homo sapiens cDNA FLJ41048 fis, clone PROST2001213, highly similar to Lysophosphatidic acid receptor Edg-4","Q9HBW0",625,0,"Lysophosphatidic acid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007202|activation of phospholipase C activity;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;","GO:0009986|cell surface;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0008289|lipid binding;GO:0070915|lysophosphatidic acid receptor activity;","K04291","LPAR2, EDG4; lysophosphatidic acid receptor 2"]
["ENSG00000242960",33,37,30,24.6559493523364,10,16,19,2.66525090367634,1.41427135304111,0.000450764120790142,0.00156176367195981,"up","yes","FTH1P23","processed_pseudogene","chr3:72929044-72929593:+","gi|426341221|ref|XP_004035948.1|",562,3e-96,"PREDICTED: ferritin heavy chain-like isoform 1 [Gorilla gorilla gorilla]","gi|586940400|ref|NG_025708.2|",550,0,"Homo sapiens ferritin, heavy polypeptide 1 pseudogene 23 (FTH1P23) on chromosome 3","P02794",218,2e-92,"Ferritin heavy chain","AF0834",66.6,4e-13,"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006879|cellular iron ion homeostasis;GO:0006955|immune response;GO:0006880|intracellular sequestering of iron ion;GO:0097286|iron ion import;GO:0008285|negative regulation of cell proliferation;GO:0048147|negative regulation of fibroblast proliferation;GO:0043312|neutrophil degranulation;","GO:0044754|autolysosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0008043|intracellular ferritin complex;GO:0005634|nucleus;","GO:0008199|ferric iron binding;GO:0004322|ferroxidase activity;GO:0005506|iron ion binding;","K00522","FTH1; ferritin heavy chain [EC:1.16.3.2]"]
["ENSG00000124701",25,12,23,14.783930779427,6,10,11,2.65794962942755,1.4103137644848,0.00846866281149243,0.0228836604522368,"up","yes","APOBEC2","protein_coding","chr6:41053304-41064511:+","gi|62898654|dbj|BAD97181.1|",1059,2e-141,"apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 variant [Homo sapiens]","gi|226342965|ref|NM_006789.3|",1151,0,"Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit 2 (APOBEC2), mRNA","Q9Y235",414,1e-143,"C->U-editing enzyme APOBEC-2",".",".",".",".","pfam08210","APOBEC_N","APOBEC-like N-terminal domain. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.","GO:0016554|cytidine to uridine editing;GO:0080111|DNA demethylation;GO:0016556|mRNA modification;GO:0006397|mRNA processing;",".","GO:0004126|cytidine deaminase activity;GO:0042802|identical protein binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;","K18772","APOBEC2; C->U-editing enzyme APOBEC2 [EC:3.5.4.-]"]
["ENSG00000186301",52,41,29,29.6922725330503,8,18,30,2.65691740432041,1.40975337941687,0.000350701482253985,0.00123571980082478,"up","yes","MST1P2","unprocessed_pseudogene","chr1:16645622-16650289:+","gi|183977|gb|AAA50165.1|",2083,0,"hepatocyte growth factor-like protein [Homo sapiens]","gi|694901788|ref|XM_516465.5|",1141,0,"PREDICTED: Pan troglodytes macrophage stimulating 1 (hepatocyte growth factor-like) (MST1), mRNA","Q2TV78",734,0,"Putative macrophage stimulating 1-like protein","VC1649",60.1,1e-08,"COG5640","pfam00089","Trypsin","Trypsin.",".","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSG00000164989",35,40,43,29.1212840260761,8,16,31,2.65310132707058,1.40767977593249,0.000371474001630876,0.00130296245562036,"up","yes","CCDC171","protein_coding","chr9:15553086-16061663:+","gi|38348729|ref|NP_775821.2|",6606,0,"coiled-coil domain-containing protein 171 [Homo sapiens]","gi|635073498|ref|XM_007969188.1|",5953,0,"PREDICTED: Chlorocebus sabaeus coiled-coil domain containing 171 (CCDC171), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".",".",".",".","."]
["ENSG00000054793",1033,1076,1054,786.128420893518,435,453,528,2.63942567881607,1.4002240430447,8.30717736543153e-58,2.78175064278547e-56,"up","yes","ATP9A","protein_coding","chr20:51596514-51768634:-","gi|65301139|ref|NP_006036.1|",5303,0,"probable phospholipid-transporting ATPase IIA [Homo sapiens]","gi|731441393|ref|NM_006045.2|",7622,0,"Homo sapiens ATPase phospholipid transporting 9A (putative) (ATP9A), mRNA","O75110",2047,0,"Probable phospholipid-transporting ATPase IIA",".",".",".",".","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0006897|endocytosis;GO:0045332|phospholipid translocation;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:0005769|early endosome;GO:0031901|early endosome membrane;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0055037|recycling endosome;GO:0005802|trans-Golgi network;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004012|phospholipid-translocating ATPase activity;","K01530","E3.6.3.1; phospholipid-translocating ATPase [EC:3.6.3.1]"]
["ENSG00000163683",458,458,439,336.497427129837,182,190,238,2.6339342161652,1.39721931400848,1.93676802981492e-34,3.8791673685431e-33,"up","yes","SMIM14","protein_coding","chr4:39546330-39639090:-","gi|767930212|ref|XP_011511942.1|",590,2e-66,"PREDICTED: small integral membrane protein 14 isoform X1 [Homo sapiens]","gi|19526148|gb|AC021148.8|",5829,0,"Homo sapiens BAC clone RP11-472B18 from 4, complete sequence","Q96QK8",207,9e-60,"Small integral membrane protein 14",".",".",".",".","pfam11027","DUF2615","Protein of unknown function (DUF2615). This small. approximately 100 residue, family is conserved from worms to humans. It is cysteine-rich with a characteristic FDxCEC sequence motif. The function is not known.",".","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000245498",29,22,15,16.1364764905563,4,15,11,2.63031448029891,1.39523529839381,0.00777320164502118,0.0211555684110581,"up","yes","AP000866.1","antisense","chr11:124800450-124834487:+","gi|355744886|gb|EHH49511.1|",155,1e-16,"hypothetical protein EGM_00180, partial [Macaca fascicularis]","gi|551873011|tpe|HG504276.1|",2886,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000388382.1 (RP11-677M14.7 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000130066",3537,3415,3186,2514.12647791043,1265,1499,1822,2.62729361891123,1.39357744100293,3.62733028334461e-205,6.85921044168145e-203,"up","yes","SAT1","protein_coding","chrX:23783173-23786226:+","gi|33086594|gb|AAP92609.1|",553,8e-95,"Ab2-402 [Rattus norvegicus]","gi|654824996|ref|NR_027783.2|",1135,0,"Homo sapiens spermidine/spermine N1-acetyltransferase 1 (SAT1), transcript variant 2, non-coding RNA","P21673",218,1e-93,"Diamine acetyltransferase 1","PA0478",80.5,4e-17,"COG0454","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0001525|angiogenesis;GO:0006596|polyamine biosynthetic process;GO:0009447|putrescine catabolic process;GO:0042127|regulation of cell proliferation;GO:0032918|spermidine acetylation;GO:0046208|spermine catabolic process;","GO:0005829|cytosol;GO:0005622|intracellular;","GO:0004145|diamine N-acetyltransferase activity;GO:0042802|identical protein binding;GO:0019809|spermidine binding;","K00657","speG; diamine N-acetyltransferase [EC:2.3.1.57]"]
["ENSG00000135114",736,696,640,513.103567108795,238,320,383,2.62582512752575,1.39277084004953,3.52145276667654e-53,1.08328199304078e-51,"up","yes","OASL","protein_coding","chr12:121019111-121039242:-","gi|11321577|ref|NP_003724.1|",2688,0,"2'-5'-oligoadenylate synthase-like protein isoform a [Homo sapiens]","gi|387849325|ref|NM_003733.3|",2085,0,"Homo sapiens 2'-5'-oligoadenylate synthetase like (OASL), transcript variant 1, mRNA","Q15646",1015,0,"2'-5'-oligoadenylate synthase-like protein",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0051607|defense response to virus;GO:0060333|interferon-gamma-mediated signaling pathway;GO:0045071|negative regulation of viral genome replication;GO:0009615|response to virus;GO:0060337|type I interferon signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;GO:0003723|RNA binding;GO:0046966|thyroid hormone receptor binding;GO:0016740|transferase activity;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSG00000196954",1644,1551,1555,1178.53289856132,549,765,842,2.62525329105802,1.39245662434994,2.89051752556974e-99,1.87718188663937e-97,"up","yes","CASP4","protein_coding","chr11:104942866-104969436:-","gi|6562163|emb|CAB43686.2|",545,5e-61,"hypothetical protein [Homo sapiens]","gi|4914591|emb|AL050391.1|",4684,0,"Homo sapiens mRNA; cDNA DKFZp586A181 (from clone DKFZp586A181); partial cds","P49662",210,2e-57,"Caspase-4",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0006915|apoptotic process;GO:1904646|cellular response to beta-amyloid;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0097193|intrinsic apoptotic signaling pathway;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0006508|proteolysis;GO:0042981|regulation of apoptotic process;GO:0050727|regulation of inflammatory response;","GO:0097169|AIM2 inflammasome complex;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0072557|IPAF inflammasome complex;GO:0005739|mitochondrion;GO:0072559|NLRP3 inflammasome complex;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0050700|CARD domain binding;GO:0004197|cysteine-type endopeptidase activity;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;","K04394","CASP4; caspase 4 [EC:3.4.22.57]"]
["ENSG00000128346",47,64,41,37.5008644074605,12,21,38,2.62199455946309,1.39066469202658,8.07648601253752e-05,0.000311620848589365,"up","yes","C22orf23","protein_coding","chr22:37943050-37953669:-","gi|332231198|ref|XP_003264785.1|",1198,2e-158,"PREDICTED: UPF0193 protein EVG1 isoform X3 [Nomascus leucogenys]","gi|333470695|ref|NM_001207062.1|",1777,0,"Homo sapiens chromosome 22 open reading frame 23 (C22orf23), transcript variant 2, mRNA",".",".",".",".",".",".",".",".","pfam05250","UPF0193","Uncharacterized protein family (UPF0193). This family of proteins is functionally uncharacterized.",".",".",".",".","."]
["ENSG00000111863",24,18,17,14.6745378113784,11,7,8,2.61975595986884,1.38943242554705,0.00915482244343984,0.024534975029744,"up","yes","ADTRP","protein_coding","chr6:11712054-11807046:-","gi|14249372|ref|NP_116133.1|",1111,7e-145,"androgen-dependent TFPI-regulating protein isoform 2 [Homo sapiens]","gi|426351610|ref|XM_004043277.1|",1933,0,"PREDICTED: Gorilla gorilla gorilla androgen-dependent TFPI-regulating protein (ADTRP), mRNA","Q96IZ2",432,2e-146,"Androgen-dependent TFPI-regulating protein",".",".",".",".","pfam04750","Far-17a_AIG1","FAR-17a/AIG1-like protein. This family includes the hamster androgen-induced FAR-17a protein, and its human homologue, the AIG1 protein. The function of these proteins is unknown. This family also includes homologous regions from a number of other metazoan proteins.","GO:0071383|cellular response to steroid hormone stimulus;GO:0042758|long-chain fatty acid catabolic process;GO:0030195|negative regulation of blood coagulation;GO:0010628|positive regulation of gene expression;","GO:0005901|caveola;GO:0009986|cell surface;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0016787|hydrolase activity;",".","."]
["ENSG00000285799",11,16,23,12.6007375754411,7,6,10,2.61608301974439,1.38740832457952,0.0173935798823129,0.0435811079202456,"up","yes","AL645929.2","transcribed_unprocessed_pseudogene","chr6:29849550-29885615:-","gi|355561739|gb|EHH18371.1|",221,1e-17,"hypothetical protein EGK_14950, partial [Macaca mulatta]","gi|23093050|emb|AL645929.4|",2062,0,"Human DNA sequence from clone CH501-12I6 on chromosome 6, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000087842",388,452,456,323.241406260254,149,204,242,2.61104369315906,1.3846265998861,9.22383184950893e-28,1.52450101725217e-26,"up","yes","PIR","protein_coding","chrX:15384799-15493564:-","gi|4505823|ref|NP_003653.1|",1551,0,"pirin [Homo sapiens]","gi|323363013|ref|NM_003662.3|",1539,0,"Homo sapiens pirin (PIR), transcript variant 1, mRNA","O00625",602,0,"Pirin","RSc0541",220,7e-66,"COG1741","pfam05726","Pirin_C","Pirin C-terminal cupin domain. This region is found the C-terminal half of the Pirin protein.","GO:0007586|digestion;GO:0030224|monocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0008127|quercetin 2,3-dioxygenase activity;GO:0003712|transcription cofactor activity;","K06911","K06911; uncharacterized protein"]
["ENSG00000225177",308,281,241,205.551971256548,102,115,162,2.60883430307011,1.38340531604867,5.38409383416753e-22,7.02627888182838e-21,"up","yes","FLJ46906","antisense","chr6:138692548-138697288:+","gi|119568298|gb|EAW47913.1|",436,4e-50,"hCG1804588 [Homo sapiens]","gi|551860446|tpe|HG499703.1|",917,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000042434.1 (RP11-390P2.4 gene), antisense",".",".",".",".",".",".",".",".","pfam14516","AAA_35","AAA-like domain. This family of proteins are part of the AAA superfamily.",".",".",".",".","."]
["ENSG00000120594",169,183,174,131.321075424883,83,60,95,2.60861397262227,1.38328346734875,8.72434830887557e-13,7.10621749077669e-12,"up","yes","PLXDC2","protein_coding","chr10:19816239-20289856:+","gi|15987495|gb|AAL11994.1|AF378757_1",2532,0,"tumor endothelial marker 7-related precursor [Homo sapiens]","gi|544346252|ref|NM_032812.8|",12264,0,"Homo sapiens plexin domain containing 2 (PLXDC2), transcript variant 1, mRNA","Q6UX71",979,0,"Plexin domain-containing protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000105642",42,30,28,24.72333045764,10,23,12,2.60709777685585,1.38244469086726,0.00118175936442606,0.00381103070072727,"up","yes","KCNN1","protein_coding","chr19:17951293-18000080:+","gi|530414845|ref|XP_005259963.1|",2601,0,"PREDICTED: small conductance calcium-activated potassium channel protein 1 isoform X2 [Homo sapiens]","gi|931605526|ref|XM_014342576.1|",2771,0,"PREDICTED: Pan paniscus potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 (KCNN1), transcript variant X4, mRNA","Q92952",946,0,"Small conductance calcium-activated potassium channel protein 1",".",".",".",".","pfam03530","SK_channel","Calcium-activated SK potassium channel.","GO:0007268|synaptic transmission;GO:0006813|potassium ion transport;","GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0005516|calmodulin binding;GO:0046982|protein heterodimerization activity;GO:0016286|small conductance calcium-activated potassium channel activity;","K04942","KCNN1; potassium intermediate/small conductance calcium-activated channel subfamily N member 1"]
["ENSG00000165917",36,21,28,20.9968995480482,10,11,18,2.6061454446336,1.38191760055851,0.00183121997762143,0.00571068244597609,"up","yes","RAPSN","protein_coding","chr11:47437757-47449178:-","gi|15619013|ref|NP_005046.2|",2177,0,"43 kDa receptor-associated protein of the synapse isoform 1 [Homo sapiens]","gi|328802668|ref|NM_005055.4|",1671,0,"Homo sapiens receptor associated protein of the synapse (RAPSN), transcript variant 1, mRNA","Q13702",843,0,"43 kDa receptor-associated protein of the synapse",".",".",".",".","pfam10579","Rapsyn_N","Rapsyn N-terminal myristoylation and linker region. Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane.","GO:0007268|synaptic transmission;GO:1903540|establishment of protein localization to postsynaptic membrane;GO:1900075|positive regulation of neuromuscular synaptic transmission;GO:0043525|positive regulation of neuron apoptotic process;GO:1901626|regulation of postsynaptic membrane organization;GO:0007271|synaptic transmission, cholinergic;","GO:0030054|cell junction;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0031594|neuromuscular junction;GO:0005886|plasma membrane;","GO:0033130|acetylcholine receptor binding;GO:0035255|ionotropic glutamate receptor binding;GO:0046872|metal ion binding;GO:0043495|protein anchor;",".","."]
["ENSG00000232860",43,33,21,23.9889587829768,16,14,13,2.60232710786346,1.37980231764051,0.00134245330276935,0.00428767002878212,"up","yes","SMG7-AS1","processed_transcript","chr1:183460874-183472265:-","gi|119611558|gb|EAW91152.1|",654,1e-77,"hCG2038242, partial [Homo sapiens]","gi|344217754|ref|NG_029808.1|",2246,0,"Homo sapiens SMG7 nonsense mediated mRNA decay factor (SMG7), RefSeqGene on chromosome 1",".",".",".",".",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.",".",".",".",".","."]
["ENSG00000140459",14,23,38,19.0053981536464,8,14,13,2.5940868820862,1.3752267996574,0.00637505626887547,0.0177357688322616,"up","yes","CYP11A1","protein_coding","chr15:74337759-74367740:-","gi|335892272|pdb|3N9Y|A",2309,0,"Chain A, Crystal Structure Of Human Cyp11a1 In Complex With Cholesterol","gi|153218653|ref|NM_001099773.1|",1995,0,"Homo sapiens cytochrome P450 family 11 subfamily A member 1 (CYP11A1), transcript variant 2, mRNA","P05108",893,0,"Cholesterol side-chain cleavage enzyme, mitochondrial","CC2997",99,3e-21,"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006700|C21-steroid hormone biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0016125|sterol metabolic process;GO:0042359|vitamin D metabolic process;","GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0008386|cholesterol monooxygenase (side-chain-cleaving) activity;GO:0020037|heme binding;GO:0005506|iron ion binding;","K00498","CYP11A; cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]"]
["ENSG00000242021",32,16,15,15.4313149933128,4,15,10,2.58194657468927,1.36845914889132,0.0123165159446325,0.0321201946376517,"up","yes","AC112493.1","lincRNA","chrX:27042907-27176298:-","gi|119619442|gb|EAW99036.1|",139,5e-09,"hCG2045649 [Homo sapiens]","gi|551893475|tpe|HG512471.1|",673,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000056135.2 (RP11-268G12.3 gene), lincRNA",".",".",".",".",".",".",".",".","pfam08497","Radical_SAM_N","Radical SAM N-terminal. This domain tends to occur to the N-terminus of the pfam04055 domain in hypothetical bacterial proteins.",".",".",".",".","."]
["ENSG00000103257",15855,15449,14456,11402.0081112662,5695,6585,8886,2.5808076555816,1.36782262315255,0,0,"up","yes","SLC7A5","protein_coding","chr16:87830023-87869488:-","gi|71979932|ref|NP_003477.4|",2191,0,"large neutral amino acids transporter small subunit 1 [Homo sapiens]","gi|71979931|ref|NM_003486.5|",4537,0,"Homo sapiens solute carrier family 7 member 5 (SLC7A5), mRNA","Q01650",848,0,"Large neutral amino acids transporter small subunit 1","BS_ykbA",139,1e-33,"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0030154|cell differentiation;GO:0006520|cellular amino acid metabolic process;GO:0050900|leukocyte migration;GO:0007399|nervous system development;GO:0015804|neutral amino acid transport;","GO:0016324|apical plasma membrane;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0015297|antiporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0042605|peptide antigen binding;","K13780","SLC7A5, LAT1; solute carrier family 7 (L-type amino acid transporter), member 5"]
["ENSG00000257556",68,38,41,36.2171660068972,16,21,31,2.58079369235615,1.36781481756093,8.45627674010712e-05,0.000325493246384327,"up","yes","LINC02298","lincRNA","chr14:105093609-105099004:+","gi|9280152|dbj|BAB01630.1|",138,1e-07,"unnamed portein product [Macaca fascicularis]","gi|551879048|tpe|HG506702.1|",965,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000409286.1 (RP11-44N21.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000283930",25,22,28,18.8567587070736,12,12,10,2.57931021487806,1.36698529718756,0.00347208829500607,0.0102228116370137,"up","yes","AL117339.5","protein_coding","chr10:38094368-38360098:+","gi|119606290|gb|EAW85884.1|",545,4e-55,"zinc finger protein 37a (KOX 21), isoform CRA_a [Homo sapiens]","gi|21540007|emb|AL133217.5|",1788,0,"Human DNA sequence from clone RP11-672F9 on chromosome 10, complete sequence","Q8N7P1",178,2e-45,"Inactive phospholipase D5",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;","GO:0003824|catalytic activity;","K16861","PLD5; inactive phospholipase D5"]
["ENSG00000128590",735,664,576,490.91244507919,252,276,383,2.57828331904211,1.36641080540574,7.80889975275732e-45,2.04089510069354e-43,"up","yes","DNAJB9","protein_coding","chr7:108569568-108574850:+","gi|426357548|ref|XP_004046099.1|",1098,3e-140,"PREDICTED: dnaJ homolog subfamily B member 9 isoform 2 [Gorilla gorilla gorilla]","gi|426357545|ref|XM_004046050.1|",2612,0,"PREDICTED: Gorilla gorilla gorilla DnaJ (Hsp40) homolog, subfamily B, member 9, transcript variant 1 (DNAJB9), mRNA","Q9UBS3",421,1e-139,"DnaJ homolog subfamily B member 9","STM0013",99.4,3e-21,"COG0484","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0030183|B cell differentiation;GO:0002377|immunoglobulin production;GO:0036498|IRE1-mediated unfolded protein response;GO:1903895|negative regulation of IRE1-mediated unfolded protein response;GO:0034976|response to endoplasmic reticulum stress;GO:0030433|ER-associated ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0070062|extracellular exosome;GO:0005730|nucleolus;","GO:0051087|chaperone binding;GO:0030544|Hsp70 protein binding;GO:0051787|misfolded protein binding;","K09515","DNAJB9; DnaJ homolog subfamily B member 9"]
["ENSG00000264006",23,12,21,14.0463318188223,10,9,6,2.5777591445174,1.36611747035456,0.0144701866218678,0.0370548148899612,"up","yes","AKR1C8P","protein_coding","chr10:5154140-5185187:-","gi|795398220|ref|XP_011754986.1|",601,1e-140,"PREDICTED: prostaglandin F synthase 1-like isoform X1 [Macaca nemestrina]","gi|574957306|ref|NR_027916.2|",2179,0,"Homo sapiens aldo-keto reductase family 1, member C8, pseudogene (AKR1C8P), non-coding RNA","Q5T2L2",263,5e-82,"Putative aldo-keto reductase family 1 member C8","BMEII1060",91.7,8e-38,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".","GO:0005737|cytoplasm;","GO:0016491|oxidoreductase activity;",".","."]
["ENSG00000163739",88,104,96,71.9514563640794,31,49,54,2.5767490977605,1.36555206647997,1.56208471161331e-08,9.08061781723855e-08,"up","yes","CXCL1","protein_coding","chr4:73869393-73871242:+","gi|4504153|ref|NP_001502.1|",411,5e-46,"growth-regulated alpha protein precursor [Homo sapiens]","gi|373432598|ref|NM_001511.3|",1097,0,"Homo sapiens C-X-C motif chemokine ligand 1 (CXCL1), transcript variant 1, mRNA","P09341",162,2e-47,"Growth-regulated alpha protein",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0030036|actin cytoskeleton organization;GO:0008283|cell proliferation;GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0019221|cytokine-mediated signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0031640|killing of cells of other organism;GO:0008285|negative regulation of cell proliferation;GO:0007399|nervous system development;GO:0043312|neutrophil degranulation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0032496|response to lipopolysaccharide;GO:0007165|signal transduction;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0035580|specific granule lumen;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;GO:0008047|enzyme activator activity;GO:0008083|growth factor activity;GO:0005102|receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSG00000132692",119,91,81,72.3022108779503,38,49,46,2.57242006631231,1.36312624845977,2.18349560847852e-08,1.25455058970312e-07,"up","yes","BCAN","protein_coding","chr1:156641390-156659532:+","gi|38372935|ref|NP_068767.3|",4167,0,"brevican core protein isoform 1 precursor [Homo sapiens]","gi|347446705|ref|NM_021948.4|",3466,0,"Homo sapiens brevican (BCAN), transcript variant 1, mRNA","Q96GW7",1601,0,"Brevican core protein",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0030206|chondroitin sulfate biosynthetic process;GO:0030207|chondroitin sulfate catabolic process;GO:0030208|dermatan sulfate biosynthetic process;GO:0030198|extracellular matrix organization;GO:0021766|hippocampus development;GO:0001501|skeletal system development;","GO:0031225|anchored component of membrane;GO:0005576|extracellular region;GO:0005796|Golgi lumen;GO:0043202|lysosomal lumen;","GO:0030246|carbohydrate binding;GO:0005201|extracellular matrix structural constituent;GO:0005540|hyaluronic acid binding;","K06795","BCAN; brevican"]
["ENSG00000119917",1188,1095,1087,840.684792435729,419,513,629,2.57039160936154,1.36198817647898,5.84650028257775e-81,2.86939688168854e-79,"up","yes","IFIT3","protein_coding","chr10:89327894-89340971:+","gi|31542980|ref|NP_001540.2|",2621,0,"interferon-induced protein with tetratricopeptide repeats 3 isoform a [Homo sapiens]","gi|576795860|ref|NM_001549.5|",2493,0,"Homo sapiens interferon induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1, mRNA","O14879",1014,0,"Interferon-induced protein with tetratricopeptide repeats 3",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0035457|cellular response to interferon-alpha;GO:0051607|defense response to virus;GO:0043066|negative regulation of apoptotic process;GO:0008285|negative regulation of cell proliferation;GO:0009615|response to virus;GO:0060337|type I interferon signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0042802|identical protein binding;",".","."]
["ENSG00000065609",25,37,23,21.3026244367158,12,14,13,2.56720319085181,1.36019748790127,0.00217897630322763,0.00668811186133903,"up","yes","SNAP91","protein_coding","chr6:83552880-83709691:-","gi|767943942|ref|XP_011534571.1|",2733,0,"PREDICTED: clathrin coat assembly protein AP180 isoform X4 [Homo sapiens]","gi|767943941|ref|XM_011536269.1|",4228,0,"PREDICTED: Homo sapiens synaptosomal-associated protein, 91kDa (SNAP91), transcript variant X7, mRNA","O60641",1048,0,"Clathrin coat assembly protein AP180",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0048268|clathrin coat assembly;GO:0015031|protein transport;GO:2000369|regulation of clathrin-mediated endocytosis;","GO:0005905|coated pit;GO:0030136|clathrin-coated vesicle;GO:0005886|plasma membrane;","GO:0005545|1-phosphatidylinositol binding;GO:0030276|clathrin binding;GO:0019901|protein kinase binding;",".","."]
["ENSG00000188599",28,32,23,20.6588411564788,6,19,14,2.55366942451341,1.35257177857129,0.00307626878617376,0.00916371773709952,"up","yes","NPIPP1","transcribed_unprocessed_pseudogene","chr16:15104312-15123498:-","gi|28279295|gb|AAH46145.1|",1343,0,"LOC339047 protein [Homo sapiens]","gi|472339069|ref|NM_001277325.1|",975,0,"Homo sapiens nuclear pore complex interacting protein family member A5 (NPIPA5), mRNA","Q9UND3",515,0,"Nuclear pore complex-interacting protein family member A1",".",".",".",".","pfam06409","NPIP","Nuclear pore complex interacting protein (NPIP). This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.","GO:0051028|mRNA transport;GO:0015031|protein transport;","GO:0031965|nuclear membrane;GO:0005643|nuclear pore;GO:0005654|nucleoplasm;",".",".","."]
["ENSG00000155428",20,16,17,13.3323973661069,11,5,8,2.55145655207779,1.35132107474789,0.0162935125374099,0.0412264554403204,"up","yes","TRIM74","protein_coding","chr7:72959485-72969466:-","gi|38524612|ref|NP_942150.1|",1318,3e-179,"tripartite motif-containing protein 74 [Homo sapiens]","gi|961349550|ref|NM_198853.2|",1350,0,"Homo sapiens tripartite motif containing 74 (TRIM74), transcript variant 1, mRNA","Q86UV6",512,1e-180,"Tripartite motif-containing protein 74",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.",".","GO:0005829|cytosol;","GO:0008270|zinc ion binding;","K12024","TRIM50_73_74; tripartite motif-containing protein 50/73/74"]
["ENSG00000172216",4257,4132,4037,3106.2218959454,1422,1871,2568,2.5506416012686,1.35086019553089,3.36790767239626e-140,3.53044582528147e-138,"up","yes","CEBPB","protein_coding","chr20:50190734-50192689:+","gi|28872796|ref|NP_005185.2|",1159,1e-150,"CCAAT/enhancer-binding protein beta isoform a [Homo sapiens]","gi|356640243|ref|NM_005194.3|",1956,0,"Homo sapiens CCAAT/enhancer binding protein beta (CEBPB), transcript variant 1, mRNA","P17676",451,3e-152,"CCAAT/enhancer-binding protein beta",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0006953|acute-phase response;GO:0050873|brown fat cell differentiation;GO:0071230|cellular response to amino acid stimulus;GO:0071347|cellular response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071407|cellular response to organic cyclic compound;GO:0042742|defense response to bacterium;GO:0001892|embryonic placenta development;GO:0002432|granuloma formation;GO:0072574|hepatocyte proliferation;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0097421|liver regeneration;GO:0060644|mammary gland epithelial cell differentiation;GO:0033598|mammary gland epithelial cell proliferation;GO:0007613|memory;GO:0043524|negative regulation of neuron apoptotic process;GO:0042130|negative regulation of T cell proliferation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030182|neuron differentiation;GO:0001541|ovarian follicle development;GO:0070169|positive regulation of biomineral tissue development;GO:0045600|positive regulation of fat cell differentiation;GO:0032753|positive regulation of interleukin-4 production;GO:0045669|positive regulation of osteoblast differentiation;GO:2000120|positive regulation of sodium-dependent phosphate transport;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045408|regulation of interleukin-6 biosynthetic process;GO:1901329|regulation of odontoblast differentiation;GO:0045670|regulation of osteoclast differentiation;GO:0060850|regulation of transcription involved in cell fate commitment;GO:0006355|regulation of transcription, DNA-templated;GO:0034976|response to endoplasmic reticulum stress;GO:0035711|T-helper 1 cell activation;GO:0006366|transcription from RNA polymerase II promoter;","GO:0036488|CHOP-C/EBP complex;GO:0000779|condensed chromosome, centromeric region;GO:0005737|cytoplasm;GO:0000790|nuclear chromatin;GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0035259|glucocorticoid receptor binding;GO:0035035|histone acetyltransferase binding;GO:0042826|histone deacetylase binding;GO:0019900|kinase binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0044389|ubiquitin-like protein ligase binding;","K10048","CEBPB; CCAAT/enhancer binding protein (C/EBP), beta"]
["ENSG00000120656",155,139,150,111.095865960392,58,60,90,2.5483919579057,1.34958718977545,2.4854977399013e-12,1.95594779303208e-11,"up","yes","TAF12","protein_coding","chr1:28589323-28643085:-","gi|667259411|ref|XP_008566899.1|",1034,2e-136,"PREDICTED: transcription initiation factor TFIID subunit 12 isoform X1 [Galeopterus variegatus]","gi|206725449|ref|NM_001135218.1|",1359,0,"Homo sapiens TATA-box binding protein associated factor 12 (TAF12), transcript variant 1, mRNA","Q16514",337,2e-113,"Transcription initiation factor TFIID subunit 12","YDR145w",109,7e-25,"COG5624","pfam03847","TFIID_20kDa","Transcription initiation factor TFIID subunit A.","GO:0006352|DNA-templated transcription, initiation;GO:0043966|histone H3 acetylation;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0051123|RNA polymerase II transcriptional preinitiation complex assembly;GO:0006366|transcription from RNA polymerase II promoter;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000125|PCAF complex;GO:0000124|SAGA complex;GO:0046695|SLIK (SAGA-like) complex;GO:0030914|STAGA complex;GO:0005669|transcription factor TFIID complex;GO:0033276|transcription factor TFTC complex;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;GO:0001102|RNA polymerase II activating transcription factor binding;GO:0017025|TBP-class protein binding;GO:0003713|transcription coactivator activity;GO:0008134|transcription factor binding;","K03126","TAF12; transcription initiation factor TFIID subunit 12"]
["ENSG00000143512",38,26,25,22.1835065049297,15,9,17,2.54595626761558,1.34820763799968,0.00201808676151814,0.00624797069922342,"up","yes","HHIPL2","protein_coding","chr1:222522258-222548103:-","gi|124248546|ref|NP_079022.2|",3792,0,"HHIP-like protein 2 precursor [Homo sapiens]","gi|124248545|ref|NM_024746.3|",2574,0,"Homo sapiens HHIP like 2 (HHIPL2), mRNA","Q6UWX4",1467,0,"HHIP-like protein 2","PAE2689",110,4e-25,"COG2133","pfam07995","GSDH","Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.",".","GO:0005576|extracellular region;","GO:0003824|catalytic activity;",".","."]
["ENSG00000178726",2467,2314,2189,1742.78261008209,869,1096,1292,2.54560774949874,1.348010132731,3.5876468692812e-150,4.11896028658903e-148,"up","yes","THBD","protein_coding","chr20:23045633-23049741:-","gi|119630577|gb|EAX10172.1|",2941,0,"thrombomodulin [Homo sapiens]","gi|237681095|ref|NG_012027.1|",4109,0,"Homo sapiens thrombomodulin (THBD), RefSeqGene (LRG_168) on chromosome 20","Q71U07",1029,0,"Thrombomodulin",".",".",".",".","pfam09064","Tme5_EGF_like","Thrombomodulin like fifth domain, EGF-like. Members of this family adopt a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with thrombin, and subsequent activation of protein-C.","GO:0007596|blood coagulation;GO:0030195|negative regulation of blood coagulation;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSG00000242553",26,18,21,16.2691574859816,11,7,12,2.54505032420295,1.34769418351521,0.0071719842119724,0.0197112042576979,"up","yes","AP001432.1","lincRNA","chr21:37221419-37237744:+","gi|675776968|ref|XP_008975892.1|",211,2e-18,"PREDICTED: Down syndrome critical region protein 9 [Pan paniscus]","gi|551891878|tpe|HG511799.1|",520,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000194798.1 (AP001432.14 gene), lincRNA",".",".",".",".",".",".",".",".","pfam02917","Pertussis_S1","Pertussis toxin, subunit 1.",".",".",".",".","."]
["ENSG00000221963",1301,1314,1241,966.022596766001,484,605,718,2.54113567850647,1.34547340706491,1.72483065988427e-84,9.04036243691517e-83,"up","yes","APOL6","protein_coding","chr22:35648395-35668409:+","gi|795130854|ref|XP_011834350.1|",1419,9e-173,"PREDICTED: apolipoprotein L6 isoform X1 [Mandrillus leucophaeus]","gi|87162462|ref|NM_030641.3|",10121,0,"Homo sapiens apolipoprotein L6 (APOL6), mRNA","Q9BWW8",533,2e-169,"Apolipoprotein L6",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005737|cytoplasm;GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["ENSG00000138944",1013,985,879,720.088377806944,366,464,515,2.5383572730545,1.34389514238175,9.71144579892761e-65,3.63012338313403e-63,"up","yes","SHISAL1","protein_coding","chr22:44243667-44312851:-","gi|795502017|ref|XP_011710359.1|",811,2e-94,"PREDICTED: uncharacterized protein KIAA1644 homolog isoform X2 [Macaca nemestrina]","gi|150010658|ref|NM_001099294.1|",6741,0,"Homo sapiens KIAA1644 (KIAA1644), mRNA","Q3SXP7",296,3e-89,"Protein shisa-like-1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000228492",25,21,19,16.1600607236993,7,8,16,2.53221381855512,1.34039923017899,0.00710552078994762,0.0195564048225613,"up","yes","RAB11FIP1P1","processed_pseudogene","chrX:74202834-74204595:+","gi|507668811|ref|XP_004637316.1|",522,7e-126,"PREDICTED: rab11 family-interacting protein 1 isoform X2 [Octodon degus]","gi|157954539|ref|NG_007008.1|",1762,0,"Homo sapiens RAB11 family interacting protein 1 (class I) pseudogene 1 (RAB11FIP1P1) on chromosome X","Q6WKZ4",245,1e-103,"Rab11 family-interacting protein 1",".",".",".",".","pfam13914","Phostensin","Phostensin PP1-binding and SH3-binding region. Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.","GO:0070164|negative regulation of adiponectin secretion;GO:0015031|protein transport;GO:0045055|regulated secretory pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0030670|phagocytic vesicle membrane;GO:0055037|recycling endosome;","GO:0017137|Rab GTPase binding;","K12484","RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5"]
["ENSG00000157514",536,433,490,365.90002943363,198,216,271,2.52652344429435,1.33715356717545,1.55819786269857e-32,2.99646264962413e-31,"up","yes","TSC22D3","protein_coding","chrX:107713221-107777342:-","gi|635145161|ref|XP_007990698.1|",1201,3e-156,"PREDICTED: TSC22 domain family protein 3 isoform X1 [Chlorocebus sabaeus]","gi|62865623|ref|NM_198057.2|",2266,0,"Homo sapiens TSC22 domain family member 3 (TSC22D3), transcript variant 1, mRNA","Q5RED5",187,4e-54,"TSC22 domain family protein 3",".",".",".",".","pfam01166","TSC22","TSC-22/dip/bun family.",".","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000185561",131,112,105,86.8469080531189,32,69,64,2.52470327493059,1.3361138397689,4.32259558179102e-09,2.62678713237508e-08,"up","yes","TLCD2","protein_coding","chr17:1702790-1710438:-","gi|795318913|ref|XP_011722556.1|",1197,3e-146,"PREDICTED: TLC domain-containing protein 2 [Macaca nemestrina]","gi|256542292|ref|NM_001164407.1|",5901,0,"Homo sapiens TLC domain containing 2 (TLCD2), mRNA","A6NGC4",405,3e-127,"TLC domain-containing protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000170442",402,277,303,245.179930552965,124,150,188,2.52296073327542,1.33511775274717,2.59361925844075e-21,3.2760791261824e-20,"up","yes","KRT86","protein_coding","chr12:52249300-52309163:+","gi|530400236|ref|XP_005268923.1|",2256,0,"PREDICTED: keratin, type II cuticular Hb6 isoform X2 [Homo sapiens]","gi|992713278|ref|NM_001320198.1|",2217,0,"Homo sapiens keratin 86 (KRT86), mRNA","O43790",869,0,"Keratin, type II cuticular Hb6",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0070268|cornification;GO:0031424|keratinization;","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0045095|keratin filament;","GO:0005198|structural molecule activity;","K07605","KRT2; type II keratin, basic"]
["ENSG00000198610",32,19,42,23.3772814288178,8,16,21,2.52010456161756,1.33348359380361,0.00274443012854425,0.0082658601373144,"up","yes","AKR1C4","protein_coding","chr10:5195462-5218949:+","gi|308153631|sp|P17516.3|AK1C4_HUMAN",1738,0,"RecName: Full=Aldo-keto reductase family 1 member C4; AltName: Full=3-alpha-HSD1; AltName: Full=3-alpha-hydroxysteroid dehydrogenase type I; AltName: Full=Chlordecone reductase; Short=CDR; AltName: Full=Dihydrodiol dehydrogenase 4; Short=DD-4; Short=DD4; AltName: Full=HAKRA","gi|820999821|ref|XM_012499415.1|",1248,0,"PREDICTED: Nomascus leucogenys aldo-keto reductase family 1 member C4 (LOC100605385), mRNA","P17516",674,0,"Aldo-keto reductase family 1 member C4","YOR120w",212,3e-63,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0008209|androgen metabolic process;GO:0015721|bile acid and bile salt transport;GO:0006699|bile acid biosynthetic process;GO:0071395|cellular response to jasmonic acid stimulus;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0001523|retinoid metabolic process;GO:0008202|steroid metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0047023|androsterone dehydrogenase activity;GO:0015125|bile acid transmembrane transporter activity;GO:0047743|chlordecone reductase activity;GO:0009055|electron carrier activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0001758|retinal dehydrogenase activity;","K00037","E1.1.1.50; 3-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.50]"]
["ENSG00000087074",6500,6067,5724,4584.53110912233,2224,2819,3639,2.51720653769566,1.33182359499895,2.36209295404983e-269,7.00923829195587e-267,"up","yes","PPP1R15A","protein_coding","chr19:48872392-48876057:+","gi|157674363|ref|NP_055145.3|",1868,0,"protein phosphatase 1 regulatory subunit 15A [Homo sapiens]","gi|157674362|ref|NM_014330.3|",2378,0,"Homo sapiens protein phosphatase 1 regulatory subunit 15A (PPP1R15A), mRNA","O75807",724,0,"Protein phosphatase 1 regulatory subunit 15A",".",".",".",".","pfam10488","PP1c_bdg","Phosphatase-1 catalytic subunit binding region. This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels.","GO:0006915|apoptotic process;GO:0007050|cell cycle arrest;GO:0006974|cellular response to DNA damage stimulus;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1903898|negative regulation of PERK-mediated unfolded protein response;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0035308|negative regulation of protein dephosphorylation;GO:1903917|positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation;GO:1902310|positive regulation of peptidyl-serine dephosphorylation;GO:0032516|positive regulation of phosphoprotein phosphatase activity;GO:0032058|positive regulation of translational initiation in response to stress;GO:0070972|protein localization to endoplasmic reticulum;GO:0036496|regulation of translational initiation by eIF2 alpha dephosphorylation;GO:0034976|response to endoplasmic reticulum stress;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;GO:0000164|protein phosphatase type 1 complex;","GO:0019901|protein kinase binding;GO:0008157|protein phosphatase 1 binding;GO:0072542|protein phosphatase activator activity;GO:0019888|protein phosphatase regulator activity;","K14019","PPP1R15A, GADD34; protein phosphatase 1 regulatory subunit 15A"]
["ENSG00000108932",43,44,30,29.2881206051754,15,20,20,2.51359646493067,1.32975305677014,0.000348936382129924,0.00123017454551672,"up","yes","SLC16A6","protein_coding","chr17:68267026-68291267:-","gi|767996441|ref|XP_005257846.2|",2463,0,"PREDICTED: monocarboxylate transporter 7 isoform X2 [Homo sapiens]","gi|292781288|ref|NM_001174166.1|",3807,0,"Homo sapiens solute carrier family 16 member 6 (SLC16A6), transcript variant 1, mRNA","O15403",949,0,"Monocarboxylate transporter 7",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08183","SLC16A6; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 6"]
["ENSG00000059915",27,26,15,16.9524752640621,9,10,13,2.51316102752918,1.32950311299137,0.00662273351186794,0.0183349051208424,"up","yes","PSD","protein_coding","chr10:102402617-102421539:-","gi|795630111|ref|XP_011733823.1|",4615,0,"PREDICTED: PH and SEC7 domain-containing protein 1 isoform X1 [Macaca nemestrina]","gi|402534557|ref|NM_002779.4|",4183,0,"Homo sapiens pleckstrin and Sec7 domain containing (PSD), transcript variant 1, mRNA","A5PKW4",1726,0,"PH and SEC7 domain-containing protein 1","YDR170c",109,6e-23,"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0031175|neuron projection development;GO:0032012|regulation of ARF protein signal transduction;GO:0007165|signal transduction;","GO:0032154|cleavage furrow;GO:0043197|dendritic spine;GO:0014069|postsynaptic density;GO:0032587|ruffle membrane;","GO:0005086|ARF guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSG00000102804",8746,8521,8023,6349.3023301422,3122,3958,4939,2.51194540065019,1.3288051063206,0,0,"up","yes","TSC22D1","protein_coding","chr13:44432143-44577147:-","gi|171460948|ref|NP_904358.2|",2993,0,"TSC22 domain family protein 1 isoform 1 [Homo sapiens]","gi|345090977|ref|NM_183422.3|",4820,0,"Homo sapiens TSC22 domain family member 1 (TSC22D1), transcript variant 1, mRNA","Q15714",1157,0,"TSC22 domain family protein 1",".",".",".",".","pfam01166","TSC22","TSC-22/dip/bun family.","GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000123999",34,23,23,19.9478519836892,10,11,17,2.50801303741066,1.32654484772481,0.00306448724155686,0.00913659503415148,"up","yes","INHA","protein_coding","chr2:219569162-219575713:+","gi|4504697|ref|NP_002182.1|",1532,0,"inhibin alpha chain preproprotein [Homo sapiens]","gi|426338685|ref|XM_004033258.1|",1433,0,"PREDICTED: Gorilla gorilla gorilla inhibin, alpha (INHA), mRNA","P05111",594,0,"Inhibin alpha chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0030509|BMP signaling pathway;GO:0007050|cell cycle arrest;GO:0048468|cell development;GO:0030154|cell differentiation;GO:0007166|cell surface receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0030218|erythrocyte differentiation;GO:0042541|hemoglobin biosynthetic process;GO:0008584|male gonad development;GO:0045578|negative regulation of B cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0045077|negative regulation of interferon-gamma biosynthetic process;GO:0045650|negative regulation of macrophage differentiation;GO:0042326|negative regulation of phosphorylation;GO:0001541|ovarian follicle development;GO:0046881|positive regulation of follicle-stimulating hormone secretion;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;GO:0042127|regulation of cell proliferation;GO:0043408|regulation of MAPK cascade;GO:0007165|signal transduction;GO:0001501|skeletal system development;GO:0060395|SMAD protein signal transduction;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0043512|inhibin A complex;GO:0043513|inhibin B complex;GO:0034673|inhibin-betaglycan-ActRII complex;GO:0043025|neuronal cell body;GO:0001917|photoreceptor inner segment;GO:0001750|photoreceptor outer segment;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0034711|inhibin binding;GO:0046982|protein heterodimerization activity;GO:0005102|receptor binding;GO:0005160|transforming growth factor beta receptor binding;","K05500","INHA; inhibin, alpha"]
["ENSG00000130363",311,279,254,211.199626892739,94,135,174,2.5077822764529,1.32641210000733,5.63752072602372e-21,7.01978694406363e-20,"up","yes","RSPH3","protein_coding","chr6:158972871-159000187:-","gi|686723790|ref|XP_003777003.2|",2537,0,"PREDICTED: radial spoke head protein 3 homolog [Pongo abelii]","gi|5918320|emb|AL035530.11|",4978,0,"Human DNA sequence from clone RP1-111C20 on chromosome 6q25.3-27, complete sequence","Q86UC2",923,0,"Radial spoke head protein 3 homolog",".",".",".",".","pfam06098","Radial_spoke_3","Radial spoke protein 3. This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organisms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.",".","GO:0005929|cilium;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["ENSG00000185745",1010,1019,946,748.051561852818,399,420,596,2.50560363589629,1.32515821124644,7.73324606943689e-60,2.67789677176479e-58,"up","yes","IFIT1","protein_coding","chr10:89392546-89406486:+","gi|400286379|ref|NP_001257856.1|",2417,0,"interferon-induced protein with tetratricopeptide repeats 1 isoform 2 [Homo sapiens]","gi|400286384|ref|NM_001270930.1|",4613,0,"Homo sapiens interferon induced protein with tetratricopeptide repeats 1 (IFIT1), transcript variant 5, mRNA","P09914",933,0,"Interferon-induced protein with tetratricopeptide repeats 1",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0071360|cellular response to exogenous dsRNA;GO:0071357|cellular response to type I interferon;GO:0051607|defense response to virus;GO:0019060|intracellular transport of viral protein in host cell;GO:0050689|negative regulation of defense response to virus by host;GO:0051097|negative regulation of helicase activity;GO:0032091|negative regulation of protein binding;GO:0045071|negative regulation of viral genome replication;GO:0045070|positive regulation of viral genome replication;GO:0009615|response to virus;GO:0060337|type I interferon signaling pathway;GO:0016032|viral process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043657|host cell;","GO:0003723|RNA binding;","K14217","IFIT1; interferon-induced protein with tetratricopeptide repeats 1"]
["ENSG00000003147",292,239,260,199.057863733088,110,135,127,2.5037545002537,1.32409310914347,2.8056315405984e-18,3.07821508276802e-17,"up","yes","ICA1","protein_coding","chr7:8113184-8262687:-","gi|12545395|ref|NP_071682.1|",2527,0,"islet cell autoantigen 1 isoform a [Homo sapiens]","gi|451327628|ref|NM_001136020.2|",2458,0,"Homo sapiens islet cell autoantigen 1 (ICA1), transcript variant 3, mRNA","Q05084",976,0,"Islet cell autoantigen 1",".",".",".",".","pfam04629","ICA69","Islet cell autoantigen ICA69, C-terminal domain. This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus. Its precise function is unknown.","GO:0006836|neurotransmitter transport;GO:0050796|regulation of insulin secretion;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000139|Golgi membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0030667|secretory granule membrane;GO:0030672|synaptic vesicle membrane;","GO:0019904|protein domain specific binding;",".","."]
["ENSG00000226476",78,43,47,41.9354218366224,23,27,29,2.49669056183425,1.32001702568309,4.86694186495268e-05,0.000193593678472277,"up","yes","LINC01748","lincRNA","chr1:60515716-60640491:-","gi|119627013|gb|EAX06608.1|",445,2e-47,"hCG2039109, partial [Homo sapiens]","gi|16973169|emb|AL603844.7|",4145,0,"Human DNA sequence from clone RP11-541I21 on chromosome 1, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000138669",69,65,66,50.4183339818664,26,35,34,2.49481649682824,1.31893370379824,2.70351321863974e-06,1.25833404828966e-05,"up","yes","PRKG2","protein_coding","chr4:81087370-81215117:-","gi|795492120|ref|XP_011708649.1|",4101,0,"PREDICTED: cGMP-dependent protein kinase 2 isoform X2 [Macaca nemestrina]","gi|541951255|ref|NM_006259.2|",4822,0,"Homo sapiens protein kinase, cGMP-dependent, type II (PRKG2), transcript variant 1, mRNA","Q13237",1581,0,"cGMP-dependent protein kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0051186|cofactor metabolic process;GO:2001226|negative regulation of chloride transport;GO:0036289|peptidyl-serine autophosphorylation;GO:0072659|protein localization to plasma membrane;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;","GO:0016324|apical plasma membrane;GO:0005829|cytosol;GO:0031965|nuclear membrane;","GO:0005524|ATP binding;GO:0030553|cGMP binding;GO:0004692|cGMP-dependent protein kinase activity;GO:0042803|protein homodimerization activity;GO:0004672|protein kinase activity;","K19477","PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]"]
["ENSG00000279443",35,23,41,25.0674058757726,16,12,19,2.49468626663241,1.31885839270347,0.00158476963311921,0.00500196967494737,"up","yes","AL513497.1","TEC","chr1:28544460-28546542:+","gi|694919214|ref|XP_009450650.1|",255,5e-22,"PREDICTED: protein GVQW1-like [Pan troglodytes]","gi|22204196|emb|AL513497.21|",2083,0,"Human DNA sequence from clone RP4-669K10 on chromosome 1, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000128564",795,727,731,566.909738816321,257,376,454,2.48192856727264,1.31146159366145,2.36354317400819e-48,6.6261658052718e-47,"up","yes","VGF","protein_coding","chr7:101162509-101165593:-","gi|116283866|gb|AAH44212.1|",847,1e-101,"VGF protein [Homo sapiens]","gi|22328094|gb|BC036537.1|",2557,0,"Homo sapiens cDNA clone IMAGE:5264788, containing frame-shift errors","O15240",325,4e-98,"Neurosecretory protein VGF",".",".",".",".","pfam06621","SIM_C","Single-minded protein C-terminus. This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologues in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerization partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism. SIM2 is thought to contribute to some specific Down syndrome phenotypes. This family is found in conjunction with a pfam00989 domain and associated pfam00785 motif.","GO:0033500|carbohydrate homeostasis;GO:0044267|cellular protein metabolic process;GO:0042742|defense response to bacterium;GO:0006091|generation of precursor metabolites and energy;GO:0042593|glucose homeostasis;GO:0030073|insulin secretion;GO:0001541|ovarian follicle development;GO:0043687|post-translational protein modification;GO:0048167|regulation of synaptic plasticity;GO:0051591|response to cAMP;GO:0009409|response to cold;GO:0002021|response to dietary excess;GO:0032868|response to insulin;GO:0019953|sexual reproduction;","GO:0031410|cytoplasmic vesicle;GO:0005788|endoplasmic reticulum lumen;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0043231|intracellular membrane-bounded organelle;GO:0030133|transport vesicle;","GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0005184|neuropeptide hormone activity;",".","."]
["ENSG00000179630",273,266,250,199.00454374012,107,121,150,2.47983977790933,1.31024691130456,2.92402288998855e-20,3.538177760483e-19,"up","yes","LACC1","protein_coding","chr13:43879284-43893932:+","gi|190194372|ref|NP_694950.2|",2208,0,"laccase domain-containing protein 1 [Homo sapiens]","gi|190194373|ref|NM_001128303.1|",4262,0,"Homo sapiens laccase domain containing 1 (LACC1), transcript variant 1, mRNA","Q8IV20",833,0,"Laccase domain-containing protein 1","BS_ylmD",111,3e-25,"COG1496","pfam02578","Cu-oxidase_4","Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.",".","GO:0005777|peroxisome;","GO:0005507|copper ion binding;","K05810","yfiH; laccase domain-containing protein"]
["ENSG00000120068",53,37,36,31.5731853065966,14,26,20,2.47974070069085,1.31018927005349,0.000334466444859098,0.00118240263717784,"up","yes","HOXB8","protein_coding","chr17:48611377-48614939:-","gi|852732474|ref|XP_012893087.1|",1104,1e-144,"PREDICTED: homeobox protein Hox-B8 isoform X1 [Dipodomys ordii]","gi|85543349|ref|NM_024016.3|",1823,0,"Homo sapiens homeobox B8 (HOXB8), mRNA","P17481",429,8e-146,"Homeobox protein Hox-B8",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0008344|adult locomotory behavior;GO:0009952|anterior/posterior pattern specification;GO:0021516|dorsal spinal cord development;GO:0048704|embryonic skeletal system morphogenesis;GO:0007625|grooming behavior;GO:0045638|negative regulation of myeloid cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0019233|sensory perception of pain;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09308","HOX_8; homeobox protein HoxB/C/D8"]
["ENSG00000100284",648,623,571,463.935689814883,238,279,369,2.47793239658931,1.30913682814205,1.86992985790753e-43,4.7085126761515e-42,"up","yes","TOM1","protein_coding","chr22:35299275-35347994:+","gi|795147258|ref|XP_011793841.1|",1641,0,"PREDICTED: LOW QUALITY PROTEIN: target of Myb protein 1 [Colobus angolensis palliatus]","gi|21757832|dbj|AK097926.1|",2576,0,"Homo sapiens cDNA FLJ40607 fis, clone THYMU2012273, highly similar to Target of Myb protein 1","O60784",526,2e-176,"Target of Myb protein 1",".",".",".",".","pfam00790","VHS","VHS domain. Domain present in VPS-27, Hrs and STAM.","GO:0006897|endocytosis;GO:0016197|endosomal transport;GO:0006886|intracellular protein transport;GO:0043312|neutrophil degranulation;GO:0015031|protein transport;","GO:0035577|azurophil granule membrane;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005769|early endosome;GO:0005768|endosome;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0035579|specific granule membrane;","GO:0030276|clathrin binding;",".","."]
["ENSG00000157680",54,29,58,35.71391754441,22,21,24,2.47778374557093,1.30905027835552,0.000307366741574841,0.00109523179595336,"up","yes","DGKI","protein_coding","chr7:137381037-137847092:-","gi|62087914|dbj|BAD92404.1|",4597,0,"diacylglycerol kinase, iota variant [Homo sapiens]","gi|10334884|gb|AC078842.2|AC078842",10302,0,"Homo sapiens chromosome 7 clone RP11-102G17, complete sequence","O75912",1717,0,"Diacylglycerol kinase iota",".",".",".",".","pfam00609","DAGK_acc","Diacylglycerol kinase accessory domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.","GO:0060079|excitatory postsynaptic potential;GO:0046959|habituation;GO:0035556|intracellular signal transduction;GO:0046834|lipid phosphorylation;GO:0007269|neurotransmitter secretion;GO:0030168|platelet activation;GO:0046579|positive regulation of Ras protein signal transduction;GO:0007205|protein kinase C-activating G-protein coupled receptor signaling pathway;GO:1900452|regulation of long term synaptic depression;GO:0051966|regulation of synaptic transmission, glutamatergic;","GO:0043679|axon terminus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0060076|excitatory synapse;GO:0032045|guanyl-nucleotide exchange factor complex;GO:0043025|neuronal cell body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0048786|presynaptic active zone;GO:0032991|macromolecular complex;GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0008021|synaptic vesicle;","GO:0005524|ATP binding;GO:0004143|diacylglycerol kinase activity;GO:0005095|GTPase inhibitor activity;GO:0046872|metal ion binding;GO:0003951|NAD+ kinase activity;GO:0017016|Ras GTPase binding;","K00901","dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]"]
["ENSG00000175197",356,376,351,272.924070401131,123,161,244,2.47379608678638,1.30672658491152,3.43211452769898e-23,4.6882878902449e-22,"up","yes","DDIT3","protein_coding","chr12:57516588-57521737:-","gi|817309172|ref|XP_012325164.1|",932,9e-123,"PREDICTED: DNA damage-inducible transcript 3 protein isoform X1 [Aotus nancymaae]","gi|304282224|ref|NM_001195053.1|",1067,0,"Homo sapiens DNA damage inducible transcript 3 (DDIT3), transcript variant 1, mRNA","P35638",294,1e-97,"DNA damage-inducible transcript 3 protein",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0036500|ATF6-mediated unfolded protein response;GO:0001955|blood vessel maturation;GO:0007050|cell cycle arrest;GO:0045454|cell redox homeostasis;GO:0006974|cellular response to DNA damage stimulus;GO:0006983|ER overload response;GO:0072655|establishment of protein localization to mitochondrion;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1990442|intrinsic apoptotic signaling pathway in response to nitrosative stress;GO:0042789|mRNA transcription from RNA polymerase II promoter;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0032792|negative regulation of CREB transcription factor activity;GO:2000016|negative regulation of determination of dorsal identity;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045599|negative regulation of fat cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0051898|negative regulation of protein kinase B signaling;GO:1903026|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0036499|PERK-mediated unfolded protein response;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:1902237|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0032757|positive regulation of interleukin-8 production;GO:0043525|positive regulation of neuron apoptotic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0045893|positive regulation of transcription, DNA-templated;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051259|protein oligomerization;GO:0043620|regulation of DNA-templated transcription in response to stress;GO:0044324|regulation of transcription involved in anterior/posterior axis specification;GO:0006355|regulation of transcription, DNA-templated;GO:0051209|release of sequestered calcium ion into cytosol;GO:0034976|response to endoplasmic reticulum stress;GO:0042594|response to starvation;GO:0006986|response to unfolded protein;GO:0016055|Wnt signaling pathway;","GO:1990622|CHOP-ATF3 complex;GO:1990617|CHOP-ATF4 complex;GO:0036488|CHOP-C/EBP complex;GO:0005829|cytosol;GO:0005770|late endosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032993|protein-DNA complex;GO:0035976|AP1 complex;","GO:0008140|cAMP response element binding protein binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043522|leucine zipper domain binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K04452","DDIT3, GADD153; DNA damage-inducible transcript 3"]
["ENSG00000125122",28,26,31,21.387919176771,7,14,21,2.47062133106407,1.30487390760741,0.0029243553887538,0.00875445704458845,"up","yes","LRRC29","protein_coding","chr16:67207139-67227048:-","gi|795233327|ref|XP_011852067.1|",1120,0,"PREDICTED: F-box/LRR-repeat protein 2 isoform X1 [Mandrillus leucophaeus]","gi|21755509|dbj|AK096101.1|",1556,0,"Homo sapiens cDNA FLJ38782 fis, clone LIVER2001113, highly similar to Leucine-rich repeat-containing protein 29","Q8WV35",378,7e-127,"Leucine-rich repeat-containing protein 29",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10275","FBXL9, LRRC29; F-box and leucine-rich repeat protein 9"]
["ENSG00000113248",37,43,31,27.9431292292298,16,10,28,2.47011002152455,1.30457530252771,0.000997700242673522,0.00326661726034407,"up","yes","PCDHB15","protein_coding","chr5:141245349-141249365:+","gi|9256610|ref|NP_061758.1|",3774,0,"protocadherin beta-15 precursor [Homo sapiens]","gi|349732422|gb|AC244130.2|",4017,0,"Homo sapiens BAC clone CH17-441C22 from chromosome 5, complete sequence","Q9Y5E8",1458,0,"Protocadherin beta-15",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007268|synaptic transmission;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399|nervous system development;GO:0007416|synapse assembly;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSG00000135047",7824,7567,7037,5656.60262812632,2833,3535,4472,2.46895785201911,1.30390220820932,0,0,"up","yes","CTSL","protein_coding","chr9:87725519-87731393:+","gi|4503155|ref|NP_001903.1|",1813,0,"cathepsin L1 isoform 1 preproprotein [Homo sapiens]","gi|16550369|dbj|AK055599.1|",2161,0,"Homo sapiens cDNA FLJ31037 fis, clone HSYRA2000137, highly similar to CATHEPSIN L PRECURSOR (EC 3.4.22.15)","P07711",702,0,"Cathepsin L1","AF1946_2",82.8,2e-16,"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0002250|adaptive immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0097067|cellular response to thyroid hormone stimulus;GO:0030574|collagen catabolic process;GO:0022617|extracellular matrix disassembly;GO:0071888|macrophage apoptotic process;GO:0006508|proteolysis;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0045616|regulation of keratinocyte differentiation;","GO:0036021|endolysosome lumen;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043202|lysosomal lumen;GO:0005764|lysosome;GO:0005634|nucleus;","GO:0005518|collagen binding;GO:0004197|cysteine-type endopeptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0001968|fibronectin binding;GO:0042393|histone binding;GO:0043394|proteoglycan binding;GO:0004252|serine-type endopeptidase activity;GO:0097655|serpin family protein binding;","K01365","CTSL; cathepsin L [EC:3.4.22.15]"]
["ENSG00000069493",21,13,20,13.6400369272895,8,7,11,2.46681222658906,1.30264790206733,0.0164857342851413,0.0416309037564554,"up","yes","CLEC2D","protein_coding","chr12:9664969-9699555:+","gi|7019447|ref|NP_037401.1|",1034,2e-126,"C-type lectin domain family 2 member D isoform 1 [Homo sapiens]","gi|393250342|ref|NM_013269.5|",5279,0,"Homo sapiens C-type lectin domain family 2 member D (CLEC2D), transcript variant 1, mRNA","Q9UHP7",402,8e-128,"C-type lectin domain family 2 member D",".",".",".",".","pfam03066","Nucleoplasmin","Nucleoplasmin. Nucleoplasmins are also known as chromatin decondensation proteins. They bind to core histones and transfer DNA to them in a reaction that requires ATP. This is thought to play a role in the assembly of regular nucleosomal arrays.","GO:0007166|cell surface receptor signaling pathway;GO:0050776|regulation of immune response;","GO:0009986|cell surface;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0030246|carbohydrate binding;GO:0004888|transmembrane signaling receptor activity;","K10072","CLEC2D; C-type lectin domain family 2 member D"]
["ENSG00000112715",2948,2921,2658,2152.56705188245,1100,1321,1708,2.46264090377839,1.30020627294128,5.53586110882549e-152,6.67348056668913e-150,"up","yes","VEGFA","protein_coding","chr6:43770184-43786487:+","gi|62088550|dbj|BAD92722.1|",787,4e-92,"vascular endothelial growth factor variant [Homo sapiens]","gi|62088549|dbj|AB209485.1|",12115,0,"Homo sapiens mRNA for vascular endothelial growth factor variant protein","P15692",218,4e-61,"Vascular endothelial growth factor A",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0032147|activation of protein kinase activity;GO:0001525|angiogenesis;GO:0048844|artery morphogenesis;GO:0002575|basophil chemotaxis;GO:0001569|patterning of blood vessels;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048593|camera-type eye morphogenesis;GO:0048739|cardiac muscle fiber development;GO:0060948|cardiac vascular smooth muscle cell development;GO:0048469|cell maturation;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0071456|cellular response to hypoxia;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0097533|cellular stress response to acid chemical;GO:0071679|commissural neuron axon guidance;GO:0060982|coronary artery morphogenesis;GO:0003169|coronary vein morphogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0071542|dopaminergic neuron differentiation;GO:0035767|endothelial cell chemotaxis;GO:0030855|epithelial cell differentiation;GO:0042462|eye photoreceptor cell development;GO:0040007|growth;GO:0003007|heart morphogenesis;GO:0001701|in utero embryonic development;GO:0050930|induction of positive chemotaxis;GO:0001822|kidney development;GO:0007595|lactation;GO:0030324|lung development;GO:0036303|lymph vessel morphogenesis;GO:0030225|macrophage differentiation;GO:0060749|mammary gland alveolus development;GO:0007498|mesoderm development;GO:0030224|monocyte differentiation;GO:0097475|motor neuron migration;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010629|negative regulation of gene expression;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0007399|nervous system development;GO:0003151|outflow tract morphogenesis;GO:0001541|ovarian follicle development;GO:0002576|platelet degranulation;GO:0050918|positive chemotaxis;GO:0045766|positive regulation of angiogenesis;GO:0048842|positive regulation of axon extension involved in axon guidance;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0045785|positive regulation of cell adhesion;GO:0051781|positive regulation of cell division;GO:0030335|positive regulation of cell migration;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:0038091|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;GO:0051272|positive regulation of cellular component movement;GO:0032793|positive regulation of CREB transcription factor activity;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0051894|positive regulation of focal adhesion assembly;GO:0010628|positive regulation of gene expression;GO:1901727|positive regulation of histone deacetylase activity;GO:0002687|positive regulation of leukocyte migration;GO:0043406|positive regulation of MAP kinase activity;GO:0060754|positive regulation of mast cell chemotaxis;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002052|positive regulation of neuroblast proliferation;GO:1900745|positive regulation of p38MAPK cascade;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0042327|positive regulation of phosphorylation;GO:0050927|positive regulation of positive chemotaxis;GO:0031954|positive regulation of protein autophosphorylation;GO:0031334|positive regulation of protein complex assembly;GO:0090037|positive regulation of protein kinase C signaling;GO:1903572|positive regulation of protein kinase D signaling;GO:1902966|positive regulation of protein localization to early endosome;GO:0001934|positive regulation of protein phosphorylation;GO:0002092|positive regulation of receptor internalization;GO:1902336|positive regulation of retinal ganglion cell axon guidance;GO:1903672|positive regulation of sprouting angiogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0061419|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0043117|positive regulation of vascular permeability;GO:0031077|post-embryonic camera-type eye development;GO:0060319|primitive erythrocyte differentiation;GO:0008360|regulation of cell shape;GO:0030823|regulation of cGMP metabolic process;GO:0090259|regulation of retinal ganglion cell axon guidance;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0061418|regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0001666|response to hypoxia;GO:0043129|surfactant homeostasis;GO:0035148|tube formation;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0001570|vasculogenesis;GO:0038190|VEGF-activated neuropilin signaling pathway;","GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016020|membrane;GO:0031093|platelet alpha granule lumen;GO:0030141|secretory granule;","GO:0042056|chemoattractant activity;GO:0005125|cytokine activity;GO:0050840|extracellular matrix binding;GO:0001968|fibronectin binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0038191|neuropilin binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0048018|receptor agonist activity;GO:0043183|vascular endothelial growth factor receptor 1 binding;GO:0043184|vascular endothelial growth factor receptor 2 binding;GO:0005172|vascular endothelial growth factor receptor binding;","K05448","VEGFA; vascular endothelial growth factor A"]
["ENSG00000138413",6268,5905,5663,4503.53074955814,2342,2791,3487,2.46248490462172,1.30011488067292,1.31151997436088e-286,4.2875588585547e-284,"up","yes","IDH1","protein_coding","chr2:208236227-208266074:-","gi|28178825|ref|NP_005887.2|",2239,0,"isocitrate dehydrogenase [NADP] cytoplasmic [Homo sapiens]","gi|538917680|ref|NM_001282387.1|",2419,0,"Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 3, mRNA","O75874",867,0,"Isocitrate dehydrogenase [NADP] cytoplasmic","SMc00480",582,0,"COG0538","pfam00180","Iso_dh","Isocitrate/isopropylmalate dehydrogenase.","GO:0006103|2-oxoglutarate metabolic process;GO:0008585|female gonad development;GO:0006749|glutathione metabolic process;GO:0006097|glyoxylate cycle;GO:0006102|isocitrate metabolic process;GO:0006740|NADPH regeneration;GO:0043312|neutrophil degranulation;GO:0006625|protein targeting to peroxisome;GO:0071071|regulation of phospholipid biosynthetic process;GO:0060696|regulation of phospholipid catabolic process;GO:0006979|response to oxidative stress;GO:0048545|response to steroid hormone;GO:0006099|tricarboxylic acid cycle;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005739|mitochondrion;GO:0005782|peroxisomal matrix;GO:0005777|peroxisome;GO:0034774|secretory granule lumen;","GO:0051990|(R)-2-hydroxyglutarate dehydrogenase activity;GO:0045296|cadherin binding;GO:0042802|identical protein binding;GO:0004450|isocitrate dehydrogenase (NADP+) activity;GO:0000287|magnesium ion binding;GO:0051287|NAD binding;GO:0050661|NADP binding;GO:0042803|protein homodimerization activity;GO:0005102|receptor binding;","K00031","IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]"]
["ENSG00000065911",3376,3061,2831,2337.99855919485,1228,1499,1738,2.46151734649735,1.29954790638876,1.22295475823004e-158,1.5417223122053e-156,"up","yes","MTHFD2","protein_coding","chr2:74198562-74217565:+","gi|635079855|ref|XP_007968376.1|",1731,0,"PREDICTED: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Chlorocebus sabaeus]","gi|18464295|gb|AC073263.5|",3489,0,"Homo sapiens BAC clone RP11-287D1 from 2, complete sequence","P13995",640,0,"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","BS_folD",251,1e-73,"COG0190","pfam02882","THF_DHG_CYH_C","Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain.","GO:0046655|folic acid metabolic process;GO:0006730|one-carbon metabolic process;GO:0046653|tetrahydrofolate metabolic process;","GO:0005615|extracellular space;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0000287|magnesium ion binding;GO:0004477|methenyltetrahydrofolate cyclohydrolase activity;GO:0004487|methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488|methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0042301|phosphate ion binding;","K13403","MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]"]
["ENSG00000205885",195,145,154,124.090260002886,49,91,101,2.45884515994795,1.29798088743147,1.47653878649887e-11,1.10642890885743e-10,"up","yes","C1RL-AS1","antisense","chr12:7108052-7122501:+","gi|119609090|gb|EAW88684.1|",672,8e-77,"hCG2038395, isoform CRA_b, partial [Homo sapiens]","gi|551873154|tpe|HG504460.1|",5272,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000398549.1 (ABC12-49244600F4.3 gene), antisense","Q9NZP8",103,2e-21,"Complement C1r subcomponent-like protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSG00000181016",58,57,56,43.3722074476062,26,27,29,2.45874929857355,1.29792464093508,1.89723359268497e-05,8.00740515004546e-05,"up","yes","LSMEM1","protein_coding","chr7:112480853-112491062:+","gi|32699019|ref|NP_872403.1|",532,4e-61,"leucine-rich single-pass membrane protein 1 [Homo sapiens]","gi|694923618|ref|XM_001167694.2|",1819,0,"PREDICTED: Pan troglodytes leucine-rich single-pass membrane protein 1 (LSMEM1), transcript variant X1, mRNA","Q8N8F7",209,1e-62,"Leucine-rich single-pass membrane protein 1",".",".",".",".","pfam15145","DUF4577","Domain of unknown function (DUF4577). The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.",".","GO:0005829|cytosol;GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000151715",131,131,114,94.6662837442117,35,73,76,2.45813545524954,1.29756441743245,2.09466135531182e-09,1.31602046323304e-08,"up","yes","TMEM45B","protein_coding","chr11:129815819-129860003:+","gi|20270331|ref|NP_620143.1|",1468,0,"transmembrane protein 45B [Homo sapiens]","gi|141802701|ref|NM_138788.3|",2207,0,"Homo sapiens transmembrane protein 45B (TMEM45B), mRNA","Q96B21",570,0,"Transmembrane protein 45B",".",".",".",".","pfam04819","DUF716","Family of unknown function (DUF716). This family is equally distributed in both metazoa and plants. Annotation associated with a member from Nicotiana tabacum suggest that it may be involved in response to viral attack in plants. However, no clear function has been assigned to this family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000147010",6059,6030,5789,4520.61436303757,2182,3016,3500,2.45648374294258,1.29659469133655,5.84369938583944e-190,9.71666153052337e-188,"up","yes","SH3KBP1","protein_coding","chrX:19533975-19887601:-","gi|13994242|ref|NP_114098.1|",2600,0,"SH3 domain-containing kinase-binding protein 1 isoform a [Homo sapiens]","gi|215490004|ref|NM_031892.2|",4731,0,"Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1), transcript variant 1, mRNA","Q96B97",1006,0,"SH3 domain-containing kinase-binding protein 1",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0006915|apoptotic process;GO:0007411|axon guidance;GO:0016477|cell migration;GO:0007267|cell-cell signaling;GO:0007010|cytoskeleton organization;GO:0006897|endocytosis;GO:0061024|membrane organization;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0008360|regulation of cell shape;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0030659|cytoplasmic vesicle membrane;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0030139|endocytic vesicle;GO:0005925|focal adhesion;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0017124|SH3 domain binding;","K12470","SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1"]
["ENSG00000204054",799,791,763,594.991856464275,293,388,463,2.45469093674685,1.29554139028683,2.40011185036766e-52,7.25601212694224e-51,"up","yes","LINC00963","processed_transcript","chr9:129483451-129513686:+","gi|355755786|gb|EHH59533.1|",316,6e-30,"hypothetical protein EGM_09670, partial [Macaca fascicularis]","gi|16508225|emb|AL391056.25|",9360,0,"Human DNA sequence from clone RP11-492E3 on chromosome 9, complete sequence","Q8WTZ3",112,5e-25,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000164296",33,25,29,22.0147624027698,15,8,19,2.45184317464099,1.29386670398655,0.0031325825023376,0.00931276992988404,"up","yes","TIGD6","protein_coding","chr5:149993118-150001167:-","gi|685548299|ref|XP_009207640.1|",2856,0,"PREDICTED: tigger transposable element-derived protein 6 isoform X1 [Papio anubis]","gi|335057557|ref|NM_030953.3|",4001,0,"Homo sapiens tigger transposable element derived 6 (TIGD6), transcript variant 1, mRNA","Q17RP2",1087,0,"Tigger transposable element-derived protein 6",".",".",".",".","pfam03184","DDE_1","DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.",".","GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["ENSG00000259404",28,21,30,20.087248253908,12,13,13,2.45067434475742,1.29317878595181,0.00395570356052562,0.0114940660252212,"up","yes","EFL1P1","transcribed_unprocessed_pseudogene","chr15:84080168-84126604:+","gi|94966754|ref|NP_078856.4|",1362,0,"elongation factor Tu GTP-binding domain-containing protein 1 isoform 1 [Homo sapiens]","gi|694961012|ref|XM_009429717.1|",854,0,"PREDICTED: Pan troglodytes elongation factor Tu GTP-binding domain-containing protein 1-like (LOC453603), transcript variant X1, mRNA","Q7Z2Z2",529,0,"Elongation factor-like GTPase 1","YNL163c",235,3e-80,"COG0480","pfam00009","GTP_EFTU","Elongation factor Tu GTP binding domain. This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.","GO:0046039|GTP metabolic process;GO:0042256|mature ribosome assembly;",".","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0043022|ribosome binding;GO:0003746|translation elongation factor activity;","K14536","RIA1; ribosome assembly protein 1 [EC:3.6.5.-]"]
["ENSG00000119508",35,46,39,30.5238185852066,15,25,18,2.4487583723598,1.292050425108,0.000519573409538924,0.00178319073366312,"up","yes","NR4A3","protein_coding","chr9:99821855-99866891:+","gi|1311505|gb|AAB36006.1|",2669,0,"steroid/thyroid orphan receptor homolog gene, partial [Homo sapiens]","gi|331999988|ref|NM_173200.2|",5706,0,"Homo sapiens nuclear receptor subfamily 4 group A member 3 (NR4A3), transcript variant 3, mRNA","Q92570",966,0,"Nuclear receptor subfamily 4 group A member 3",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0030534|adult behavior;GO:0031100|organ regeneration;GO:0007411|axon guidance;GO:0045333|cellular respiration;GO:0071870|cellular response to catecholamine stimulus;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0044320|cellular response to leptin stimulus;GO:0035726|common myeloid progenitor cell proliferation;GO:0097009|energy homeostasis;GO:0045444|fat cell differentiation;GO:0007369|gastrulation;GO:0021766|hippocampus development;GO:0043303|mast cell degranulation;GO:0001707|mesoderm formation;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:0043524|negative regulation of neuron apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0050885|neuromuscular process controlling balance;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0045787|positive regulation of cell cycle;GO:0050679|positive regulation of epithelial cell proliferation;GO:0046321|positive regulation of fatty acid oxidation;GO:2000253|positive regulation of feeding behavior;GO:0010828|positive regulation of glucose transport;GO:2000108|positive regulation of leukocyte apoptotic process;GO:0038097|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0032765|positive regulation of mast cell cytokine production;GO:1900625|positive regulation of monocyte aggregation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0009444|pyruvate oxidation;GO:0045652|regulation of megakaryocyte differentiation;GO:0048660|regulation of smooth muscle cell proliferation;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0048752|semicircular canal morphogenesis;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0060005|vestibular reflex;","GO:0042629|mast cell granule;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0001046|core promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0035259|glucocorticoid receptor binding;GO:0035035|histone acetyltransferase binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0004887|thyroid hormone receptor activity;GO:0001223|transcription coactivator binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0008270|zinc ion binding;","K08559","NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3"]
["ENSG00000147162",20296,18299,18014,14318.6227900564,7335,9265,10956,2.44328083841236,1.2888197010585,0,0,"up","yes","OGT","protein_coding","chrX:71533083-71575897:+","gi|504171490|ref|XP_004595331.1|",4021,0,"PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [Ochotona princeps]","gi|4914599|emb|AL050366.1|",5455,0,"Homo sapiens mRNA; cDNA DKFZp564A126 (from clone DKFZp564A126); partial cds","O15294",1551,0,"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit","CC1107",140,7e-33,"COG3914","pfam13844","Glyco_transf_41","Glycosyl transferase family 41. This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues. In addition to its function as an O-GlcNAc transferase, human OGT also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1.","GO:0006915|apoptotic process;GO:0032922|circadian regulation of gene expression;GO:0080182|histone H3-K4 trimethylation;GO:0043984|histone H4-K16 acetylation;GO:0043981|histone H4-K5 acetylation;GO:0043982|histone H4-K8 acetylation;GO:0032435|negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031397|negative regulation of protein ubiquitination;GO:0048015|phosphatidylinositol-mediated signaling;GO:0061087|positive regulation of histone H3-K27 methylation;GO:0045862|positive regulation of proteolysis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016579|protein deubiquitination;GO:0006493|protein O-linked glycosylation;GO:0016485|protein processing;GO:0006111|regulation of gluconeogenesis;GO:0006110|regulation of glycolytic process;GO:0046626|regulation of insulin receptor signaling pathway;GO:0035020|regulation of Rac protein signal transduction;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0032868|response to insulin;GO:0007584|response to nutrient;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0000123|histone acetyltransferase complex;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0008375|acetylglucosaminyltransferase activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0016262|protein N-acetylglucosaminyltransferase activity;GO:0097363|protein O-GlcNAc transferase activity;","K09667","OGT; protein O-GlcNAc transferase [EC:2.4.1.255]"]
["ENSG00000250802",22,28,20,17.738233245268,7,17,10,2.44130901921338,1.28765492202184,0.0084683182531326,0.0228836604522368,"up","yes","ZBED3-AS1","antisense","chr5:77086688-77166909:+","gi|119616203|gb|EAW95797.1|",453,7e-49,"hCG2038610, partial [Homo sapiens]","gi|23621912|gb|AC008581.11|",4190,0,"Homo sapiens chromosome 5 clone CTC-564N23, complete sequence","P63159",115,7e-27,"High mobility group protein B1",".",".",".",".","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.","GO:0031532|actin cytoskeleton reorganization;GO:0002250|adaptive immune response;GO:0043277|apoptotic cell clearance;GO:0006914|autophagy;GO:0000902|cell morphogenesis;GO:0071347|cellular response to interleukin-1;GO:0006935|chemotaxis;GO:0007623|circadian rhythm;GO:0032392|DNA geometric change;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0050930|induction of positive chemotaxis;GO:0006954|inflammatory response;GO:0050831|male-specific defense response to bacterium;GO:0051450|myoblast proliferation;GO:0008156|negative regulation of DNA replication;GO:0007399|nervous system development;GO:0031175|neuron projection development;GO:0097350|neutrophil clearance;GO:0043065|positive regulation of apoptotic process;GO:0010508|positive regulation of autophagy;GO:0010942|positive regulation of cell death;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0051106|positive regulation of DNA ligation;GO:0032732|positive regulation of interleukin-1 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0071642|positive regulation of macrophage inflammatory protein 1 alpha production;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0045931|positive regulation of mitotic cell cycle;GO:0033034|positive regulation of myeloid cell apoptotic process;GO:0045663|positive regulation of myoblast differentiation;GO:0010976|positive regulation of neuron projection development;GO:0014911|positive regulation of smooth muscle cell migration;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0032760|positive regulation of tumor necrosis factor production;GO:0050727|regulation of inflammatory response;GO:0002840|regulation of T cell mediated immune response to tumor cell;GO:0042493|response to drug;GO:0009749|response to glucose;GO:0009408|response to heat;GO:0032868|response to insulin;GO:0034341|response to interferon-gamma;GO:0032496|response to lipopolysaccharide;","GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005768|endosome;GO:0005615|extracellular space;GO:0045121|membrane raft;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0008097|5S rRNA binding;GO:0003681|bent DNA binding;GO:0000405|bubble DNA binding;GO:0000402|crossed form four-way junction DNA binding;GO:0005125|cytokine activity;GO:0008301|DNA binding, bending;GO:0003690|double-stranded DNA binding;GO:0000400|four-way junction DNA binding;GO:0051861|glycolipid binding;GO:0008201|heparin binding;GO:0000401|open form four-way junction DNA binding;GO:0042277|peptide binding;GO:0046983|protein dimerization activity;GO:0050786|RAGE receptor binding;GO:0003697|single-stranded DNA binding;GO:0097100|supercoiled DNA binding;GO:0008134|transcription factor binding;","K10802","HMGB1; high mobility group protein B1"]
["ENSG00000128298",27,32,18,19.495464772733,14,8,15,2.43927551697795,1.28645272022052,0.00613005450178421,0.0171134015386328,"up","yes","BAIAP2L2","protein_coding","chr22:38084889-38110670:-","gi|113205091|ref|NP_079321.3|",2229,0,"brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 [Homo sapiens]","gi|574957079|ref|NM_025045.5|",2145,0,"Homo sapiens BAI1 associated protein 2 like 2 (BAIAP2L2), mRNA","Q6UXY1",863,0,"Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2",".",".",".",".","pfam08397","IMD","IRSp53/MIM homology domain. The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent.","GO:0051764|actin crosslink formation;GO:0051017|actin filament bundle assembly;GO:0008286|insulin receptor signaling pathway;GO:0061024|membrane organization;GO:0007009|plasma membrane organization;GO:2000251|positive regulation of actin cytoskeleton reorganization;GO:0030838|positive regulation of actin filament polymerization;","GO:0015629|actin cytoskeleton;GO:0044291|cell-cell contact zone;GO:0071439|clathrin complex;GO:0030659|cytoplasmic vesicle membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0012506|vesicle membrane;","GO:0005543|phospholipid binding;",".","."]
["ENSG00000089847",27,27,22,19.2537362320397,9,16,12,2.42900866340532,1.28036763556028,0.00498103295897156,0.0141660518597233,"up","yes","ANKRD24","protein_coding","chr19:4183354-4224814:+","gi|768001157|ref|XP_011526059.1|",4311,0,"PREDICTED: ankyrin repeat domain-containing protein 24 isoform X2 [Homo sapiens]","gi|126723389|ref|NM_133475.1|",4026,0,"Homo sapiens ankyrin repeat domain 24 (ANKRD24), mRNA",".",".",".",".","all2748",90.9,4e-18,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSG00000172361",22,15,19,14.1016414560643,6,7,15,2.42768331836721,1.27958024003732,0.016867998120525,0.0424351047017982,"up","yes","CFAP53","protein_coding","chr18:50227193-50266522:-","gi|675786710|ref|XP_003827259.2|",2286,0,"PREDICTED: cilia- and flagella-associated protein 53 [Pan paniscus]","gi|916532139|ref|NM_145020.4|",1851,0,"Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA","Q96M91",855,0,"Cilia- and flagella-associated protein 53",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0060271|cilium morphogenesis;GO:0003341|cilium movement;GO:0007368|determination of left/right symmetry;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;","GO:0005929|cilium;",".",".","."]
["ENSG00000187595",32,30,25,22.1850538501461,16,17,8,2.4266883572767,1.27898884508565,0.0045852634280526,0.0131666757481433,"up","yes","ZNF385C","protein_coding","chr17:42025576-42098479:-","gi|172044654|sp|Q66K41.2|Z385C_HUMAN",1380,7e-180,"RecName: Full=Zinc finger protein 385C","gi|337299687|ref|NM_001242704.1|",2596,0,"Homo sapiens zinc finger protein 385C (ZNF385C), mRNA","Q66K41",535,0,"Zinc finger protein 385C",".",".",".",".","pfam12874","zf-met","Zinc-finger of C2H2 type. This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.","GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;","GO:0005634|nucleus;","GO:0002039|p53 binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["ENSG00000133134",296,275,265,212.10763088816,109,148,152,2.42522613936004,1.27811927716462,4.43890555661643e-20,5.3344305530229e-19,"up","yes","BEX2","protein_coding","chrX:103309346-103311046:-","gi|270309182|ref|NP_001161871.1|",782,7e-101,"protein BEX2 isoform 1 [Homo sapiens]","gi|270309181|ref|NM_001168399.1|",1077,0,"Homo sapiens brain expressed X-linked 2 (BEX2), transcript variant 1, mRNA","Q9BXY8",238,1e-76,"Protein BEX2",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0006915|apoptotic process;GO:0007049|cell cycle;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["ENSG00000106105",10373,10149,9533,7629.30809693014,3961,4793,6051,2.41980091636722,1.27488835791951,0,0,"up","yes","GARS","protein_coding","chr7:30594681-30634033:+","gi|116805340|ref|NP_002038.2|",3705,0,"glycine--tRNA ligase isoform 1 precursor [Homo sapiens]","gi|943350814|ref|NM_001316772.1|",2580,0,"Homo sapiens glycyl-tRNA synthetase (GARS), transcript variant 2, mRNA","P41250",1431,0,"Glycine--tRNA ligase","SPAC3F10.03",630,0,"COG0423","pfam00587","tRNA-synt_2b","tRNA synthetase class II core domain (G, H, P, S and T). Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.","GO:0015966|diadenosine tetraphosphate biosynthetic process;GO:0070150|mitochondrial glycyl-tRNA aminoacylation;GO:0006418|tRNA aminoacylation for protein translation;","GO:0030424|axon;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0030141|secretory granule;","GO:0005524|ATP binding;GO:0004081|bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0004820|glycine-tRNA ligase activity;GO:0042802|identical protein binding;GO:0046983|protein dimerization activity;","K01880","GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14]"]
["ENSG00000115267",300,278,277,216.808482514665,105,138,180,2.41831350998127,1.27400128758785,1.0466448066759e-20,1.28665933914371e-19,"up","yes","IFIH1","protein_coding","chr2:162267079-162318703:-","gi|27886568|ref|NP_071451.2|",4766,0,"interferon-induced helicase C domain-containing protein 1 [Homo sapiens]","gi|395393979|ref|NM_022168.3|",3595,0,"Homo sapiens interferon induced, with helicase C domain 1 (IFIH1), mRNA","Q9BYX4",1840,0,"Interferon-induced helicase C domain-containing protein 1","PAB0190_1",107,3e-23,"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0071360|cellular response to exogenous dsRNA;GO:0039528|cytoplasmic pattern recognition receptor signaling pathway in response to virus;GO:0051607|defense response to virus;GO:0009597|detection of virus;GO:0045087|innate immune response;GO:0039530|MDA-5 signaling pathway;GO:0032480|negative regulation of type I interferon production;GO:0032727|positive regulation of interferon-alpha production;GO:1902741|positive regulation of interferon-alpha secretion;GO:0032728|positive regulation of interferon-beta production;GO:0035549|positive regulation of interferon-beta secretion;GO:2000778|positive regulation of interleukin-6 secretion;GO:0060760|positive regulation of response to cytokine stimulus;GO:1904469|positive regulation of tumor necrosis factor secretion;GO:0016579|protein deubiquitination;GO:0016925|protein sumoylation;GO:0034344|regulation of type III interferon production;GO:0009615|response to virus;GO:0016032|viral process;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;GO:0004386|helicase activity;GO:0042802|identical protein binding;GO:0043021|ribonucleoprotein complex binding;GO:0003727|single-stranded RNA binding;GO:0008270|zinc ion binding;","K12647","IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]"]
["ENSG00000254860",24,23,15,15.7261607176778,11,8,11,2.4133645369406,1.27104585003972,0.0123616075056999,0.0322290734752555,"up","yes","TMEM9B-AS1","antisense","chr11:8964675-8977527:+","gi|119589012|gb|EAW68606.1|",445,2e-51,"hCG1814450 [Homo sapiens]","gi|418203934|ref|NR_073431.1|",1053,0,"Homo sapiens TMEM9B antisense RNA 1 (TMEM9B-AS1), long non-coding RNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSG00000232160",17,24,13,13.6448475118276,5,10,12,2.41324271001896,1.27097302078855,0.0203717001924741,0.0499846525012646,"up","yes","RAP2C-AS1","antisense","chrX:132217147-132432862:+","gi|119588610|gb|EAW68204.1|",301,3e-28,"hCG2033532 [Homo sapiens]","gi|551894159|tpe|HG512688.1|",3473,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000058317.1 (RP5-842K24.2 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000196208",250,251,249,190.625494203206,91,123,159,2.40999969241952,1.26903296232874,5.93340384088651e-18,6.40422458214992e-17,"up","yes","GREB1","protein_coding","chr2:11482341-11642788:+","gi|23397642|ref|NP_055483.2|",9668,0,"protein GREB1 isoform a [Homo sapiens]","gi|116734674|ref|NM_014668.3|",8482,0,"Homo sapiens growth regulation by estrogen in breast cancer 1 (GREB1), transcript variant a, mRNA","Q4ZG55",3717,0,"Protein GREB1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;",".",".","."]
["ENSG00000184227",45,67,37,37.8256617295847,19,23,32,2.40886033944397,1.26835075163683,0.000204481066972171,0.000745845465158706,"up","yes","ACOT1","protein_coding","chr14:73537114-73543794:+","gi|119601524|gb|EAW81118.1|",2206,0,"hCG21524, isoform CRA_a [Homo sapiens]","gi|28071003|emb|BX161396.1|",1668,0,"human full-length cDNA clone CS0DC012YL01 of Neuroblastoma of Homo sapiens (human)","P49753",852,0,"Acyl-coenzyme A thioesterase 2, mitochondrial","CAC3407",152,2e-39,"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0006637|acyl-CoA metabolic process;GO:0001676|long-chain fatty acid metabolic process;GO:0006625|protein targeting to peroxisome;GO:0000038|very long-chain fatty acid metabolic process;","GO:0005829|cytosol;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0005782|peroxisomal matrix;","GO:0047617|acyl-CoA hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0005102|receptor binding;","K01068","ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]"]
["ENSG00000153823",669,660,632,499.334437554011,280,303,385,2.40583798255533,1.26653948971504,6.401428591115e-42,1.56490183352885e-40,"up","yes","PID1","protein_coding","chr2:228850526-229271285:-","gi|795231264|ref|XP_011807346.1|",1354,1e-177,"PREDICTED: PTB-containing, cubilin and LRP1-interacting protein isoform X1 [Colobus angolensis palliatus]","gi|154937328|ref|NM_017933.4|",2745,0,"Homo sapiens phosphotyrosine interaction domain containing 1 (PID1), transcript variant 1, mRNA","Q7Z2X4",405,5e-133,"PTB-containing, cubilin and LRP1-interacting protein",".",".",".",".","pfam14719","PID_2","Phosphotyrosine interaction domain (PTB/PID).","GO:0071345|cellular response to cytokine stimulus;GO:0071398|cellular response to fatty acid;GO:0071354|cellular response to interleukin-6;GO:0044320|cellular response to leptin stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0006112|energy reserve metabolic process;GO:0070584|mitochondrion morphogenesis;GO:2001170|negative regulation of ATP biosynthetic process;GO:2001274|negative regulation of glucose import in response to insulin stimulus;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:1903077|negative regulation of protein localization to plasma membrane;GO:0001933|negative regulation of protein phosphorylation;GO:2001171|positive regulation of ATP biosynthetic process;GO:0070346|positive regulation of fat cell proliferation;GO:0010628|positive regulation of gene expression;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0010635|regulation of mitochondrial fusion;GO:0051881|regulation of mitochondrial membrane potential;GO:2000377|regulation of reactive oxygen species metabolic process;","GO:0005737|cytoplasm;",".",".","."]
["ENSG00000186594",636,652,653,494.177422541008,249,298,421,2.40434533723727,1.26564412589037,5.22991284540965e-38,1.14891297223532e-36,"up","yes","MIR22HG","lincRNA","chr17:1711493-1717174:-","gi|119610992|gb|EAW90586.1|",350,1e-35,"hypothetical protein MGC14376, isoform CRA_b [Homo sapiens]","gi|551883319|tpe|HG508543.1|",2626,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000438299.2 (MIR22HG gene), lincRNA",".",".",".",".",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".",".",".",".","."]
["ENSG00000127415",309,252,270,210.995328823509,106,134,173,2.40102154190728,1.26364834745146,1.78476379324892e-19,2.08760000267951e-18,"up","yes","IDUA","protein_coding","chr4:986997-1004506:+","gi|767929117|ref|XP_011511761.1|",2471,0,"PREDICTED: alpha-L-iduronidase isoform X1 [Homo sapiens]","gi|767929116|ref|XM_011513459.1|",2171,0,"PREDICTED: Homo sapiens iduronidase, alpha-L- (IDUA), transcript variant X1, mRNA","P35475",442,0,"Alpha-L-iduronidase","BH1068",65.5,3e-10,"COG3664","pfam01229","Glyco_hydro_39","Glycosyl hydrolases family 39.","GO:0030207|chondroitin sulfate catabolic process;GO:0030209|dermatan sulfate catabolic process;GO:0005984|disaccharide metabolic process;GO:0006027|glycosaminoglycan catabolic process;","GO:0030135|coated vesicle;GO:0070062|extracellular exosome;GO:0043202|lysosomal lumen;","GO:0003940|L-iduronidase activity;GO:0005102|receptor binding;","K01217","IDUA; L-iduronidase [EC:3.2.1.76]"]
["ENSG00000224032",601,594,573,449.693583133485,224,273,386,2.39934261467696,1.26263918230942,4.22682322629113e-37,9.04849793437328e-36,"up","yes","EPB41L4A-AS1","lincRNA","chr5:112160526-112164276:+","gi|15425669|dbj|BAB64313.1|",598,4e-69,"TIGA1 [Homo sapiens]","gi|551856953|tpe|HG498332.1|",2969,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000250735.3 (EPB41L4A-AS1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSG00000162105",323,279,298,228.567069135824,98,162,191,2.39685801171973,1.26114444722019,2.61733657269912e-19,3.03384542152769e-18,"up","yes","SHANK2","protein_coding","chr11:70467856-71252577:-","gi|254911082|ref|NP_573573.2|",5382,0,"SH3 and multiple ankyrin repeat domains protein 2 isoform 2 [Homo sapiens]","gi|588480513|ref|NM_133266.4|",8795,0,"Homo sapiens SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 2, mRNA","Q9UPX8",2007,0,"SH3 and multiple ankyrin repeat domains protein 2",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.","GO:0030534|adult behavior;GO:0007612|learning;GO:0060292|long term synaptic depression;GO:0060291|long-term synaptic potentiation;GO:0035176|social behavior;GO:0007416|synapse assembly;GO:0071625|vocalization behavior;","GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0030054|cell junction;GO:0060170|ciliary membrane;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0030426|growth cone;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0001917|photoreceptor inner segment;GO:0001750|photoreceptor outer segment;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0030160|GKAP/Homer scaffold activity;GO:0035255|ionotropic glutamate receptor binding;GO:0017124|SH3 domain binding;","K15009","SHANK; SH3 and multiple ankyrin repeat domains protein"]
["ENSG00000162591",272,221,227,182.78663125848,89,125,144,2.39626005674768,1.26078448668302,4.56821140792575e-17,4.70681953184144e-16,"up","yes","MEGF6","protein_coding","chr1:3489920-3611495:-","gi|72534475|dbj|BAE19678.1|",7544,0,"hypothetical protein [Homo sapiens]","gi|110347456|ref|NM_001409.3|",5455,0,"Homo sapiens multiple EGF like domains 6 (MEGF6), mRNA","O75095",2845,0,"Multiple epidermal growth factor-like domains protein 6",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.",".","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;",".","."]
["ENSG00000139410",683,701,614,508.179267375285,254,322,421,2.39530720516596,1.26021069769306,6.9011645078605e-42,1.68280228859183e-40,"up","yes","SDSL","protein_coding","chr12:113422237-113438276:+","gi|19923959|ref|NP_612441.1|",1444,0,"serine dehydratase-like [Homo sapiens]","gi|675799982|ref|XM_003832430.2|",1393,0,"PREDICTED: Pan paniscus serine dehydratase-like (SDSL), transcript variant X1, mRNA","Q96GA7",560,0,"Serine dehydratase-like","YCL064c",132,3e-33,"COG1171","pfam00291","PALP","Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.","GO:0019518|L-threonine catabolic process to glycine;","GO:0005829|cytosol;","GO:0016836|hydro-lyase activity;GO:0042802|identical protein binding;GO:0003941|L-serine ammonia-lyase activity;GO:0004794|L-threonine ammonia-lyase activity;GO:0030170|pyridoxal phosphate binding;","K17989","SDS, SDH, CHA1; L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]"]
["ENSG00000100439",3355,3275,3192,2500.41270879917,1191,1638,2095,2.39444188611881,1.25968942132225,1.04099286363348e-123,9.29568071933454e-122,"up","yes","ABHD4","protein_coding","chr14:22598237-22613215:+","gi|50658087|ref|NP_071343.2|",1832,0,"protein ABHD4 [Homo sapiens]","gi|767981279|ref|XM_005267986.3|",2981,0,"PREDICTED: Homo sapiens abhydrolase domain containing 4 (ABHD4), transcript variant X1, mRNA","Q8TB40",710,0,"Protein ABHD4","SPAC6G10.03c",121,5e-28,"COG0596","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.","GO:0016042|lipid catabolic process;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;","GO:0005789|endoplasmic reticulum membrane;","GO:0016787|hydrolase activity;","K13698","ABHD4; abhydrolase domain-containing protein 4"]
["ENSG00000012822",1556,1423,1335,1096.99227622945,566,709,871,2.39348936297358,1.25911539451836,4.24085058382372e-89,2.4272262926051e-87,"up","yes","CALCOCO1","protein_coding","chr12:53708517-53727745:-","gi|119617137|gb|EAW96731.1|",3279,0,"calcium binding and coiled-coil domain 1, isoform CRA_e [Homo sapiens]","gi|16603965|gb|AC076968.38|",3607,0,"Homo sapiens 12 BAC RP11-686F15 (Roswell Park Cancer Institute Human BAC Library) complete sequence","Q9P1Z2",1263,0,"Calcium-binding and coiled-coil domain-containing protein 1",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.","GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0007165|signal transduction;GO:0006351|transcription, DNA-templated;GO:0016055|Wnt signaling pathway;","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0000790|nuclear chromatin;GO:0005634|nucleus;","GO:0070016|armadillo repeat domain binding;GO:0008013|beta-catenin binding;GO:0003682|chromatin binding;GO:0030374|ligand-dependent nuclear receptor transcription coactivator activity;GO:0008022|protein C-terminus binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0003712|transcription cofactor activity;GO:0044212|transcription regulatory region DNA binding;",".","."]
["ENSG00000137628",615,572,514,432.512250369153,222,282,343,2.39062836653407,1.25738987432814,4.86981298595726e-38,1.07347374712164e-36,"up","yes","DDX60","protein_coding","chr4:168216293-168318807:-","gi|222831595|ref|NP_060101.3|",9118,0,"probable ATP-dependent RNA helicase DDX60 [Homo sapiens]","gi|222831594|ref|NM_017631.5|",6071,0,"Homo sapiens DEXD/H-box helicase 60 (DDX60), mRNA","Q8IY21",3516,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",497,1e-144,"COG4581","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0051607|defense response to virus;GO:0045087|innate immune response;GO:1900245|positive regulation of MDA-5 signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;GO:0009615|response to virus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0045111|intermediate filament cytoskeleton;","GO:0005524|ATP binding;GO:0003690|double-stranded DNA binding;GO:0003725|double-stranded RNA binding;GO:0004386|helicase activity;GO:0003727|single-stranded RNA binding;",".","."]
["ENSG00000224034",136,91,95,81.7331224403867,46,59,53,2.38989971333854,1.25695008008688,8.25536622462833e-08,4.4840750138167e-07,"up","yes","LINC02561","lincRNA","chr10:5266033-5271236:-",".",".",".",".","gi|551868682|tpe|HG502618.1|",692,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000046542.1 (RP11-445P17.8 gene), lincRNA",".",".",".",".",".",".",".",".","pfam10050","DUF2284","Predicted metal-binding protein (DUF2284). Members of this family of metal-binding hypothetical bacterial proteins have no known function.",".",".",".",".","."]
["ENSG00000232909",38,12,27,19.4898394298694,12,10,16,2.38775860599927,1.25565699257802,0.0105802054921181,0.0279779275475699,"up","yes","AL157823.2","antisense","chr6:35733867-35736947:-","gi|119624251|gb|EAX03846.1|",286,9e-30,"hCG2001161 [Homo sapiens]","gi|574957291|ref|NR_027117.2|",669,0,"Homo sapiens uncharacterized LOC285847 (LOC285847), long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000151917",67,68,58,49.201372460354,26,34,36,2.38479323478596,1.25386418779052,9.05551897731342e-06,3.97322224828074e-05,"up","yes","BEND6","protein_coding","chr6:56955126-57027342:+","gi|972779184|ref|NP_001305468.1|",551,3e-62,"BEN domain-containing protein 6 isoform 2 [Homo sapiens]","gi|972779183|ref|NM_001318539.1|",3497,0,"Homo sapiens BEN domain containing 6 (BEND6), transcript variant 2, mRNA","Q5SZJ8",202,2e-56,"BEN domain-containing protein 6",".",".",".",".","pfam04849","HAP1_N","HAP1 N-terminal conserved region. This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.","GO:0045746|negative regulation of Notch signaling pathway;GO:0045666|positive regulation of neuron differentiation;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0001106|RNA polymerase II transcription corepressor activity;",".","."]
["ENSG00000269335",765,795,697,576.046200768528,329,349,445,2.38393509619494,1.25334495825296,1.17408398674686e-43,2.97200886205237e-42,"up","yes","IKBKG","protein_coding","chrX:154541199-154565046:+","gi|223671870|ref|NP_001093326.2|",1717,0,"NF-kappa-B essential modulator isoform b [Homo sapiens]","gi|544063455|ref|NM_001099857.2|",2259,0,"Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 1, mRNA","Q9Y6K9",654,0,"NF-kappa-B essential modulator",".",".",".",".","pfam11577","NEMO","NF-kappa-B essential modulator NEMO. NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK.","GO:0000187|activation of MAPK activity;GO:0043276|anoikis;GO:0002479|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0051650|establishment of vesicle localization;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0007254|JNK cascade;GO:0002756|MyD88-independent toll-like receptor signaling pathway;GO:1901215|negative regulation of neuron death;GO:0070423|nucleotide-binding oligomerization domain containing signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016239|positive regulation of macroautophagy;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016579|protein deubiquitination;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0009615|response to virus;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0051403|stress-activated MAPK cascade;GO:0050852|T cell receptor signaling pathway;GO:0006351|transcription, DNA-templated;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0016032|viral process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0008385|IkappaB kinase complex;GO:0005622|intracellular;GO:0072686|mitotic spindle;GO:0005634|nucleus;GO:0000922|spindle pole;GO:0000151|ubiquitin ligase complex;","GO:0042802|identical protein binding;GO:0070530|K63-linked polyubiquitin binding;GO:1990450|linear polyubiquitin binding;GO:0046872|metal ion binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0031625|ubiquitin protein ligase binding;","K07210","IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma"]
["ENSG00000128272",16229,15936,14884,11997.2432451476,6067,7887,9641,2.38163636926012,1.25195315782337,0,0,"up","yes","ATF4","protein_coding","chr22:39519695-39522685:+","gi|33469974|ref|NP_877962.1|",1460,0,"cyclic AMP-dependent transcription factor ATF-4 [Homo sapiens]","gi|584277093|ref|NM_001675.4|",2019,0,"Homo sapiens activating transcription factor 4 (ATF4), transcript variant 1, mRNA","P18848",566,0,"Cyclic AMP-dependent transcription factor ATF-4",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0006520|cellular amino acid metabolic process;GO:0034198|cellular response to amino acid starvation;GO:1903351|cellular response to dopamine;GO:0042149|cellular response to glucose starvation;GO:0090650|cellular response to oxygen-glucose deprivation;GO:0034644|cellular response to UV;GO:0032922|circadian regulation of gene expression;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0006094|gluconeogenesis;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0042789|mRNA transcription from RNA polymerase II promoter;GO:1903204|negative regulation of oxidative stress-induced neuron death;GO:0043267|negative regulation of potassium ion transport;GO:0032057|negative regulation of translational initiation in response to stress;GO:0030182|neuron differentiation;GO:0036499|PERK-mediated unfolded protein response;GO:0043065|positive regulation of apoptotic process;GO:1902237|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0010628|positive regulation of gene expression;GO:0043525|positive regulation of neuron apoptotic process;GO:0045943|positive regulation of transcription from RNA polymerase I promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0061395|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0036091|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0036003|positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0045893|positive regulation of transcription, DNA-templated;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0006355|regulation of transcription, DNA-templated;GO:0034976|response to endoplasmic reticulum stress;GO:1990737|response to manganese-induced endoplasmic reticulum stress;GO:0009636|response to toxic substance;GO:0006366|transcription from RNA polymerase II promoter;","GO:1990590|ATF1-ATF4 transcription factor complex;GO:1990589|ATF4-CREB1 transcription factor complex;GO:1990617|CHOP-ATF4 complex;GO:0005737|cytoplasm;GO:0032590|dendrite membrane;GO:1990037|Lewy body core;GO:0005815|microtubule organizing center;GO:0043005|neuron projection;GO:0034399|nuclear periphery;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0001046|core promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043522|leucine zipper domain binding;GO:0008022|protein C-terminus binding;GO:0046982|protein heterodimerization activity;GO:0019901|protein kinase binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0001076|transcription factor activity, RNA polymerase II transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K04374","ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4"]
["ENSG00000129595",63,62,62,47.8497772146037,29,28,36,2.38092403792606,1.25152159294947,1.36238248298367e-05,5.85508764077295e-05,"up","yes","EPB41L4A","protein_coding","chr5:112142441-112419316:-","gi|292495006|sp|Q9HCS5.2|E41LA_HUMAN",3374,0,"RecName: Full=Band 4.1-like protein 4A; AltName: Full=Protein NBL4","gi|87042274|ref|NM_022140.3|",4701,0,"Homo sapiens erythrocyte membrane protein band 4.1 like 4A (EPB41L4A), mRNA","Q9HCS5",1300,0,"Band 4.1-like protein 4A",".",".",".",".","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.","GO:0031032|actomyosin structure organization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0008092|cytoskeletal protein binding;GO:0005200|structural constituent of cytoskeleton;",".","."]
["ENSG00000204248",76,66,68,53.3795416898698,27,23,57,2.37650371575806,1.24884065735308,1.75211030431501e-05,7.42904012961704e-05,"up","yes","COL11A2","protein_coding","chr6:33162681-33192499:-","gi|478500040|ref|XP_004424344.1|",2508,0,"PREDICTED: collagen alpha-2(XI) chain isoform X1 [Ceratotherium simum simum]","gi|111118969|ref|NM_080680.2|",6425,0,"Homo sapiens collagen type XI alpha 2 (COL11A2), transcript variant 1, mRNA","P13942",929,0,"Collagen alpha-2(XI) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0051216|cartilage development;GO:0030199|collagen fibril organization;GO:0060021|palate development;GO:0007605|sensory perception of sound;GO:0001501|skeletal system development;GO:0060023|soft palate development;","GO:0005592|collagen type XI trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;","GO:0030020|extracellular matrix structural constituent conferring tensile strength;GO:0046872|metal ion binding;GO:0030674|protein binding, bridging;",".","."]
["ENSG00000150471",23,24,22,17.8180846801528,16,10,7,2.37542896416548,1.24818806442987,0.0130147230757029,0.0337448553144451,"up","yes","ADGRL3","protein_coding","chr4:61201258-62078335:+","gi|11037016|gb|AAG27462.1|AF307080_1",6216,0,"lectomedin-3 [Homo sapiens]","gi|767931516|ref|XM_011531792.1|",8227,0,"PREDICTED: Homo sapiens adhesion G protein-coupled receptor L3 (ADGRL3), transcript variant X9, mRNA","Q80TS3",2264,0,"Adhesion G protein-coupled receptor L3",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0007166|cell surface receptor signaling pathway;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:0031987|locomotion involved in locomotory behavior;GO:0001764|neuron migration;GO:0051965|positive regulation of synapse assembly;GO:0042220|response to cocaine;GO:0007416|synapse assembly;","GO:0030424|axon;GO:0005911|cell-cell junction;GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;GO:0030246|carbohydrate binding;GO:0004930|G-protein coupled receptor activity;","K04594","LPHN3; latrophilin 3"]
["ENSG00000114812",143,158,150,115.042912319785,46,80,104,2.37350645949833,1.24701997606755,2.56599854564513e-10,1.7501053729987e-09,"up","yes","VIPR1","protein_coding","chr3:42489299-42537573:+","gi|353523865|ref|NP_001238812.1|",628,1e-70,"vasoactive intestinal polypeptide receptor 1 isoform 3 [Homo sapiens]","gi|34533367|dbj|AK126759.1|",3729,0,"Homo sapiens cDNA FLJ44806 fis, clone BRACE3042432, highly  similar to Vasoactive intestinal polypeptide receptor 1 precursor","P32241",248,4e-70,"Vasoactive intestinal polypeptide receptor 1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007187|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0008284|positive regulation of cell proliferation;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0017046|peptide hormone binding;GO:0004999|vasoactive intestinal polypeptide receptor activity;","K04589","VIPR1; vasoactive intestinal peptide receptor 1"]
["ENSG00000140044",287,314,239,213.788192502939,95,134,199,2.36753560663553,1.24338612331994,2.92274217900433e-16,2.89096672557106e-15,"up","yes","JDP2","protein_coding","chr14:75427716-75474111:+","gi|205277421|ref|NP_001128521.1|",698,2e-80,"jun dimerization protein 2 isoform b [Homo sapiens]","gi|6648145|gb|AC009363.4|AC009363",4823,0,"Homo sapiens chromosome 14 clone CTD-2317F5 map 14q24.3, complete sequence","Q8WYK2",256,2e-76,"Jun dimerization protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0045599|negative regulation of fat cell differentiation;GO:0031065|positive regulation of histone deacetylation;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0046982|protein heterodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09033","JDP2; jun dimerization protein 2"]
["ENSG00000250116",30,30,18,19.8284367708674,10,15,14,2.36209800986911,1.24006882731703,0.00606006083558871,0.0169327036646147,"up","yes","AC018682.1","antisense","chr2:46568256-46580238:-",".",".",".",".","gi|540344604|ref|NR_104182.1|",1519,0,"Homo sapiens uncharacterized LOC100506142 (LOC100506142), long non-coding RNA",".",".",".",".",".",".",".",".","pfam14672","LCE","Late cornified envelope. This is a family of late cornified envelope proteins that are expressed in skin.",".",".",".",".","."]
["ENSG00000023909",6556,5938,5835,4690.20818073131,2489,3161,3610,2.3510099902661,1.23328066952124,7.61273129977551e-232,1.68775127942609e-229,"up","yes","GCLM","protein_coding","chr1:93885205-93909456:-","gi|472366033|ref|XP_004402562.1|",1346,1e-169,"PREDICTED: glutamate--cysteine ligase regulatory subunit isoform X1 [Odobenus rosmarus divergens]","gi|821325132|ref|NM_002061.3|",4857,0,"Homo sapiens glutamate-cysteine ligase modifier subunit (GCLM), transcript variant 1, mRNA","Q2T9Y6",518,3e-169,"Glutamate--cysteine ligase regulatory subunit","SPCC737.06c",83.2,4e-16,"COG0656","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0008637|apoptotic mitochondrial changes;GO:1990830|cellular response to leukemia inhibitory factor;GO:0006534|cysteine metabolic process;GO:0006536|glutamate metabolic process;GO:0006750|glutathione biosynthetic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0035229|positive regulation of glutamate-cysteine ligase activity;GO:0050880|regulation of blood vessel size;GO:0051900|regulation of mitochondrial depolarization;GO:0042493|response to drug;GO:0006979|response to oxidative stress;","GO:0017109|glutamate-cysteine ligase complex;","GO:0030234|enzyme regulator activity;GO:0004357|glutamate-cysteine ligase activity;GO:0035226|glutamate-cysteine ligase catalytic subunit binding;GO:0046982|protein heterodimerization activity;","K11205","GCLM; glutamate--cysteine ligase regulatory subunit"]
["ENSG00000106686",18,22,16,14.269777214122,5,10,14,2.34590429114345,1.23014415509304,0.0199632590025078,0.0490823887368223,"up","yes","SPATA6L","protein_coding","chr9:4553386-4666674:-","gi|767955072|ref|XP_011516255.1|",844,5e-99,"PREDICTED: spermatogenesis associated 6-like protein isoform X4 [Homo sapiens]","gi|34368202|emb|BX649030.1|",4044,0,"Homo sapiens mRNA; cDNA DKFZp686C1298 (from clone DKFZp686C1298)",".",".",".",".",".",".",".",".","pfam14909","SPATA6","Spermatogenesis-assoc protein 6. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family has similarity to the motor domain of kinesin related proteins and with the Caenorhabditis elegans neural calcium sensor protein (NCS###2).",".",".",".",".","."]
["ENSG00000141519",64,55,57,45.2430794390832,30,28,30,2.34450310181734,1.22928218776999,4.08455217074687e-05,0.000164404929610529,"up","yes","CCDC40","protein_coding","chr17:80036632-80100613:+","gi|148664197|ref|NP_060420.2|",5170,0,"coiled-coil domain-containing protein 40 isoform 1 [Homo sapiens]","gi|343183423|ref|NM_017950.3|",4294,0,"Homo sapiens coiled-coil domain containing 40 (CCDC40), transcript variant 1, mRNA","Q4G0X9",1996,0,"Coiled-coil domain-containing protein 40",".",".",".",".","pfam08647","BRE1","BRE1 E3 ubiquitin ligase. BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions.","GO:0070286|axonemal dynein complex assembly;GO:0003341|cilium movement;GO:0071907|determination of digestive tract left/right asymmetry;GO:0071910|determination of liver left/right asymmetry;GO:0035469|determination of pancreatic left/right asymmetry;GO:0003351|epithelial cilium movement;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;GO:0030317|sperm motility;GO:0001947|heart looping;GO:0036159|inner dynein arm assembly;GO:0030324|lung development;GO:0044458|motile cilium assembly;GO:0003356|regulation of cilium beat frequency;","GO:0005930|axoneme;GO:0005929|cilium;GO:0005737|cytoplasm;",".",".","."]
["ENSG00000103021",58,39,66,41.9629394370603,22,30,31,2.33747463888436,1.22495071214284,0.000149659381958058,0.000557372110292917,"up","yes","CCDC113","protein_coding","chr16:58231157-58283836:+","gi|19923432|ref|NP_054876.2|",1824,0,"coiled-coil domain-containing protein 113 isoform 1 [Homo sapiens]","gi|214830909|ref|NM_014157.3|",5269,0,"Homo sapiens coiled-coil domain containing 113 (CCDC113), transcript variant 1, mRNA","Q9H0I3",707,0,"Coiled-coil domain-containing protein 113",".",".",".",".","pfam13870","DUF4201","Domain of unknown function (DUF4201). This is a family of coiled-coil proteins from eukaryotes. The function is not known.","GO:0060271|cilium morphogenesis;","GO:0034451|centriolar satellite;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;",".",".","."]
["ENSG00000101104",3160,2543,2585,2120.90057917761,1126,1398,1694,2.33457397557163,1.22315930393647,2.09306774003719e-106,1.48970813910839e-104,"up","yes","PABPC1L","protein_coding","chr20:44910062-44959035:+","gi|675783543|ref|XP_008949573.1|",794,5e-92,"PREDICTED: polyadenylate-binding protein 1-like isoform X2 [Pan paniscus]","gi|983173885|ref|NR_134984.1|",2223,0,"Homo sapiens poly(A) binding protein, cytoplasmic 1-like (PABPC1L), transcript variant 6, non-coding RNA","Q4VXU2",296,4e-88,"Polyadenylate-binding protein 1-like",".",".",".",".","pfam00658","PABP","Poly-adenylate binding protein, unique domain. The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (pfam00076). Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.","GO:0048096|chromatin-mediated maintenance of transcription;GO:0006378|mRNA polyadenylation;GO:0051647|nucleus localization;GO:0001556|oocyte maturation;","GO:0070062|extracellular exosome;","GO:0003723|RNA binding;","K13126","PABPC; polyadenylate-binding protein"]
["ENSG00000234432",29,22,19,17.7943898454233,9,9,18,2.33379130696171,1.22267555767223,0.00992093546518357,0.0263683344705058,"up","yes","AC092171.3","lincRNA","chr7:5426277-5428927:-","gi|34531361|dbj|BAC86121.1|",963,1e-120,"unnamed protein product [Homo sapiens]","gi|551861071|tpe|HG499978.1|",2651,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000472302.1 (RP11-1275H24.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSG00000162004",248,211,225,175.506893384721,92,121,136,2.33070872408193,1.22076871764581,8.25604806463494e-16,7.96611581143965e-15,"up","yes","CCDC78","protein_coding","chr16:722582-726954:-","gi|119606143|gb|EAW85737.1|",1442,0,"coiled-coil domain containing 78, isoform CRA_d [Homo sapiens]","gi|34535957|dbj|AK128538.1|",3425,0,"Homo sapiens cDNA FLJ46696 fis, clone TRACH3013072","A2IDD5",260,8e-76,"Coiled-coil domain-containing protein 78",".",".",".",".","pfam14739","DUF4472","Domain of unknown function (DUF4472). This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, pfam00225.","GO:0030030|cell projection organization;GO:0098535|de novo centriole assembly;GO:0003009|skeletal muscle contraction;","GO:0005814|centriole;GO:0098536|deuterosome;GO:0048471|perinuclear region of cytoplasm;GO:0042383|sarcolemma;GO:0016529|sarcoplasmic reticulum;",".",".","."]
["ENSG00000160161",81,52,75,53.4748238933098,26,46,34,2.31911218752831,1.21357261234091,3.65243263344833e-05,0.000147969167473118,"up","yes","CILP2","protein_coding","chr19:19538248-19546659:+","gi|119605239|gb|EAW84833.1|",5757,0,"cartilage intermediate layer protein 2, isoform CRA_b [Homo sapiens]","gi|34534774|dbj|AK127735.1|",4232,0,"Homo sapiens cDNA FLJ45835 fis, clone NT2RP8008057, weakly  similar to Homo sapiens cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP)","Q8IUL8",2205,0,"Cartilage intermediate layer protein 2",".",".",".",".","pfam13330","Mucin2_WxxW","Mucin-2 protein WxxW repeating region. This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in a member from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.",".","GO:0070062|extracellular exosome;",".",".","."]
["ENSG00000008394",5969,5639,5501,4399.16623853398,2353,2864,3582,2.31697252492811,1.21224093657003,1.33568702332882e-242,3.26110522860333e-240,"up","yes","MGST1","protein_coding","chr12:16347142-16609259:+","gi|341915910|ref|XP_003403541.1|",382,7e-39,"PREDICTED: uncharacterized protein LOC100652901 [Homo sapiens]","gi|16554031|dbj|AK058030.1|",2131,0,"Homo sapiens cDNA FLJ25301 fis, clone STM07812",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000145362",1472,1326,1218,1031.28148995991,562,694,801,2.31604983978987,1.21166629946015,8.02638453556469e-74,3.52648986154833e-72,"up","yes","ANK2","protein_coding","chr4:112818109-113383740:+","gi|52426735|ref|NP_001139.3|",18616,0,"ankyrin-2 isoform 1 [Homo sapiens]","gi|188595661|ref|NM_001148.4|",14196,0,"Homo sapiens ankyrin 2, neuronal (ANK2), transcript variant 1, mRNA","Q01484",7175,0,"Ankyrin-2","all2748",196,7e-52,"COG0666","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0086014|atrial cardiac muscle cell action potential;GO:0086066|atrial cardiac muscle cell to AV node cell communication;GO:0003283|atrial septum development;GO:0006874|cellular calcium ion homeostasis;GO:0034613|cellular protein localization;GO:0006897|endocytosis;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0086046|membrane depolarization during SA node cell action potential;GO:0030913|paranodal junction assembly;GO:1901021|positive regulation of calcium ion transmembrane transporter activity;GO:0051928|positive regulation of calcium ion transport;GO:2001259|positive regulation of cation channel activity;GO:0010628|positive regulation of gene expression;GO:1901018|positive regulation of potassium ion transmembrane transporter activity;GO:0043268|positive regulation of potassium ion transport;GO:0034394|protein localization to cell surface;GO:0070972|protein localization to endoplasmic reticulum;GO:0036309|protein localization to M-band;GO:0033365|protein localization to organelle;GO:0072659|protein localization to plasma membrane;GO:0036371|protein localization to T-tubule;GO:0050821|protein stabilization;GO:0015031|protein transport;GO:0098910|regulation of atrial cardiac muscle cell action potential;GO:1901019|regulation of calcium ion transmembrane transporter activity;GO:0051924|regulation of calcium ion transport;GO:0086004|regulation of cardiac muscle cell contraction;GO:0055117|regulation of cardiac muscle contraction;GO:0010882|regulation of cardiac muscle contraction by calcium ion signaling;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0002027|regulation of heart rate;GO:0086091|regulation of heart rate by cardiac conduction;GO:0031647|regulation of protein stability;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0098907|regulation of SA node cell action potential;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0051597|response to methylmercury;GO:0086015|SA node cell action potential;GO:0086070|SA node cell to atrial cardiac muscle cell communication;GO:0070296|sarcoplasmic reticulum calcium ion transport;GO:0033292|T-tubule organization;GO:0086005|ventricular cardiac muscle cell action potential;","GO:0031672|A band;GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0043034|costamere;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005769|early endosome;GO:0014704|intercalated disc;GO:0005622|intracellular;GO:0005764|lysosome;GO:0031430|M band;GO:0045121|membrane raft;GO:0005739|mitochondrion;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;GO:0055037|recycling endosome;GO:0042383|sarcolemma;GO:0030315|T-tubule;GO:0030018|Z disc;","GO:0051117|ATPase binding;GO:0019899|enzyme binding;GO:0044325|ion channel binding;GO:0030674|protein binding, bridging;GO:0019901|protein kinase binding;GO:0030507|spectrin binding;GO:0005200|structural constituent of cytoskeleton;","K10380","ANK; ankyrin"]
["ENSG00000187193",35,27,25,22.2199941599345,12,11,22,2.31578090687691,1.21149876821753,0.00431772329730161,0.0124447470051335,"up","yes","MT1X","protein_coding","chr16:56682424-56684196:+","gi|119603292|gb|EAW82886.1|",296,9e-29,"metallothionein 1X, isoform CRA_b [Homo sapiens]","gi|29568022|gb|AC026461.11|",1727,0,"Homo sapiens chromosome 16 clone RP11-249C24, complete sequence",".",".",".",".",".",".",".",".","pfam15244","HSD3","Hydroxy-steroid dehydrogenase. This family also goes by the name of Spermatogenesis-associated protein 7 or SPAT7. It is an aldo-keto reductase (AKR) human type 3 3-alpha-hydroxy-steroid dehydrogenase (H3-alpha-HSD3, AKR1C2), and it plays a crucial role in the regulation of the intracellular concentrations of testosterone and 5-alpha-dihydrotestosterone (5-alpha-DHT), two steroids directly linked to the aetiology and the progression of many prostate diseases and cancer. Mutations in the gene cause Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP), the most common hereditary causes of visual impairment in infants and children.",".",".",".",".","."]
["ENSG00000168672",675,652,576,488.99017128784,268,312,398,2.31436344660962,1.21061544242635,3.29427634717913e-39,7.54631854921509e-38,"up","yes","FAM84B","protein_coding","chr8:126552442-126558393:-","gi|28557798|ref|NP_777571.1|",1369,4e-171,"protein FAM84B [Homo sapiens]","gi|307611973|ref|NM_174911.4|",5404,0,"Homo sapiens family with sequence similarity 84 member B (FAM84B), mRNA","Q96KN1",531,1e-172,"Protein FAM84B",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005737|cytoplasm;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000181019",15025,14848,13660,11198.0717693942,5789,7461,9246,2.31182118733228,1.20902981387432,0,0,"up","yes","NQO1","protein_coding","chr16:69706996-69726951:-","gi|197099224|ref|NP_001125152.1|",1384,0,"NAD(P)H dehydrogenase [quinone] 1 [Pongo abelii]","gi|70995356|ref|NM_000903.2|",2591,0,"Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1, mRNA","Q5RD31",537,0,"NAD(P)H dehydrogenase [quinone] 1","PA4975",158,2e-42,"COG2249","pfam02525","Flavodoxin_2","Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species.  This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.","GO:0043086|negative regulation of catalytic activity;GO:0006979|response to oxidative stress;","GO:0005829|cytosol;","GO:0042802|identical protein binding;GO:0003955|NAD(P)H dehydrogenase (quinone) activity;","K00355","NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]"]
["ENSG00000266714",87,69,67,56.9941342895601,24,40,52,2.31119487675377,1.20863891098379,6.25233257142325e-06,2.79090466645711e-05,"up","yes","MYO15B","protein_coding","chr17:75588058-75626501:+","gi|967240406|ref|XP_014976000.1|",9665,0,"PREDICTED: unconventional myosin-XV-like [Macaca mulatta]","gi|21687271|tpg|BK000056.1|",4659,0,"TPA_exp: Homo sapiens myosin unconventional myosin XVBP pseudogene mRNA, complete sequence","Q96JP2",2128,0,"Unconventional myosin-XVB","YOR326w",297,5e-80,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).",".","GO:0005737|cytoplasm;GO:0016459|myosin complex;","GO:0005524|ATP binding;GO:0003774|motor activity;","K10361","MYO15; myosin XV"]
["ENSG00000105204",486,457,434,353.587004141036,175,217,324,2.30949871318116,1.20757974233864,6.6931211352579e-27,1.074017641072e-25,"up","yes","DYRK1B","protein_coding","chr19:39825350-39834201:-","gi|530417538|ref|XP_005259452.1|",2574,0,"PREDICTED: dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1 [Homo sapiens]","gi|768011944|ref|XM_005259395.2|",2719,0,"PREDICTED: Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X1, mRNA","Q9Y463",987,0,"Dual specificity tyrosine-phosphorylation-regulated kinase 1B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060612|adipose tissue development;GO:0007520|myoblast fusion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;","GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0003713|transcription coactivator activity;","K08825","DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]"]
["ENSG00000226314",75,67,57,51.11870809069,29,34,39,2.30810841063072,1.20671098819751,1.31324142104551e-05,5.65649855496332e-05,"up","yes","ZNF192P1","transcribed_unprocessed_pseudogene","chr6:28161769-28169594:+","gi|675650629|ref|XP_008992021.1|",1385,0,"PREDICTED: zinc finger protein 383-like isoform X1 [Callithrix jacchus]","gi|495534203|ref|NR_103448.1|",1398,0,"Homo sapiens zinc finger protein 192 pseudogene 1 (ZNF192P1), non-coding RNA","Q15776",327,5e-102,"Zinc finger protein with KRAB and SCAN domains 8",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09229","ZKSCAN; KRAB and SCAN domains-containing zinc finger protein"]
["ENSG00000165272",328,351,325,258.821518809679,139,163,218,2.30636580810022,1.20562135413333,2.81206558983917e-21,3.54504059456326e-20,"up","yes","AQP3","protein_coding","chr9:33441154-33447633:-","gi|158257848|dbj|BAF84897.1|",396,2e-65,"unnamed protein product [Homo sapiens]","gi|21754606|dbj|AK095363.1|",2899,0,"Homo sapiens cDNA FLJ38044 fis, clone CTONG2014119, moderately similar to AQUAPORIN 3","Q92482",157,6e-67,"Aquaporin-3","STM4087",70.1,3e-15,"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0071456|cellular response to hypoxia;GO:0090650|cellular response to oxygen-glucose deprivation;GO:0007588|excretion;GO:0042476|odontogenesis;GO:0002684|positive regulation of immune system process;GO:0045616|regulation of keratinocyte differentiation;GO:0070295|renal water absorption;GO:0003091|renal water homeostasis;GO:0051592|response to calcium ion;GO:0032526|response to retinoic acid;GO:0033280|response to vitamin D;GO:0015840|urea transport;GO:0006833|water transport;","GO:0016323|basolateral plasma membrane;GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0015254|glycerol channel activity;GO:0005215|transporter activity;GO:0015250|water channel activity;","K09876","AQP3; aquaporin-3"]
["ENSG00000142657",7064,7015,6774,5373.12013522846,2776,3524,4529,2.30486935765983,1.20468497954931,2.02770828760534e-197,3.65518107021792e-195,"up","yes","PGD","protein_coding","chr1:10398592-10420144:+","gi|397503050|ref|XP_003822149.1|",2524,0,"PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating isoform X2 [Pan paniscus]","gi|751130503|ref|NM_002631.3|",1885,0,"Homo sapiens phosphogluconate dehydrogenase (PGD), transcript variant 1, mRNA","P52209",961,0,"6-phosphogluconate dehydrogenase, decarboxylating","VCA0898",643,0,"COG0362","pfam00393","6PGD","6-phosphogluconate dehydrogenase, C-terminal domain. This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase.   The domain contains two structural repeats of 5 helices each.","GO:0019521|D-gluconate metabolic process;GO:0055114|oxidation-reduction process;GO:0019322|pentose biosynthetic process;GO:0006098|pentose-phosphate shunt;GO:0009051|pentose-phosphate shunt, oxidative branch;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005634|nucleus;","GO:0004616|phosphogluconate dehydrogenase (decarboxylating) activity;","K00033","PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]"]
["ENSG00000246090",44,46,43,34.1459920567734,14,22,34,2.30388228017387,1.20406700230617,0.000449911775664983,0.00155909060888002,"up","yes","AP002026.1","antisense","chr4:99088857-99301356:+","gi|982316569|ref|XP_015297476.1|",325,3e-28,"PREDICTED: endogenous retrovirus group V member 2 Env polyprotein [Macaca fascicularis]","gi|551853506|tpe|HG497098.1|",4825,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000364248.1 (RP11-696N14.1 gene), antisense","B6SEH9",124,6e-28,"Endogenous retrovirus group V member 2 Env polyprotein","AGpA280",62.8,4e-09,"COG1062","pfam08240","ADH_N","Alcohol dehydrogenase GroES-like domain. This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000100219",3574,3634,3392,2733.49175016949,1482,1751,2264,2.29993323200645,1.20159197975602,4.23212419769149e-141,4.48512151236668e-139,"up","yes","XBP1","protein_coding","chr22:28794555-28800597:-","gi|675756971|ref|XP_003820222.2|",889,5e-109,"PREDICTED: LOW QUALITY PROTEIN: X-box-binding protein 1 [Pan paniscus]","gi|21752785|dbj|AK093842.1|",2170,0,"Homo sapiens cDNA FLJ36523 fis, clone TRACH2002664","P17861",231,3e-68,"X-box-binding protein 1",".",".",".",".","pfam04632","FUSC","Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, from Burkholderia cepacia and Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.","GO:0060612|adipose tissue development;GO:0001525|angiogenesis;GO:0036500|ATF6-mediated unfolded protein response;GO:0006914|autophagy;GO:0016049|cell growth;GO:0071230|cellular response to amino acid stimulus;GO:0071498|cellular response to fluid shear stress;GO:0071332|cellular response to fructose stimulus;GO:0042149|cellular response to glucose starvation;GO:0071333|cellular response to glucose stimulus;GO:0032869|cellular response to insulin stimulus;GO:0071353|cellular response to interleukin-4;GO:0071499|cellular response to laminar fluid shear stress;GO:1990830|cellular response to leukemia inhibitory factor;GO:0071222|cellular response to lipopolysaccharide;GO:0031670|cellular response to nutrient;GO:0034599|cellular response to oxidative stress;GO:0071375|cellular response to peptide hormone stimulus;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0035356|cellular triglyceride homeostasis;GO:0042632|cholesterol homeostasis;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0001935|endothelial cell proliferation;GO:0060691|epithelial cell maturation involved in salivary gland development;GO:0031017|exocrine pancreas development;GO:0006633|fatty acid biosynthetic process;GO:0055089|fatty acid homeostasis;GO:0006955|immune response;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0036498|IRE1-mediated unfolded protein response;GO:0001889|liver development;GO:0007517|muscle organ development;GO:0043066|negative regulation of apoptotic process;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1900102|negative regulation of endoplasmic reticulum unfolded protein response;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0010832|negative regulation of myotube differentiation;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0048666|neuron development;GO:0006996|organelle organization;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0045766|positive regulation of angiogenesis;GO:0010508|positive regulation of autophagy;GO:0045579|positive regulation of B cell differentiation;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:1900103|positive regulation of endoplasmic reticulum unfolded protein response;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:1903071|positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:0045600|positive regulation of fat cell differentiation;GO:2000347|positive regulation of hepatocyte proliferation;GO:0031062|positive regulation of histone methylation;GO:0002639|positive regulation of immunoglobulin production;GO:0051024|positive regulation of immunoglobulin secretion;GO:2000778|positive regulation of interleukin-6 secretion;GO:1903489|positive regulation of lactation;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:1900413|positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter;GO:1900100|positive regulation of plasma cell differentiation;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:1901985|positive regulation of protein acetylation;GO:0042307|positive regulation of protein import into nucleus;GO:0051897|positive regulation of protein kinase B signaling;GO:0001934|positive regulation of protein phosphorylation;GO:0045582|positive regulation of T cell differentiation;GO:0032008|positive regulation of TOR signaling;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0006990|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0035470|positive regulation of vascular wound healing;GO:0031648|protein destabilization;GO:0015031|protein transport;GO:0010506|regulation of autophagy;GO:0031647|regulation of protein stability;GO:0034976|response to endoplasmic reticulum stress;GO:1990418|response to insulin-like growth factor stimulus;GO:0055092|sterol homeostasis;GO:0006366|transcription from RNA polymerase II promoter;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0031490|chromatin DNA binding;GO:0001047|core promoter binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0001158|enhancer sequence-specific DNA binding;GO:0030331|estrogen receptor binding;GO:0002020|protease binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0031625|ubiquitin protein ligase binding;","K09027","XBP1; X box-binding protein 1"]
["ENSG00000116285",17923,17447,16615,13400.091918736,7267,8711,10949,2.29991568028852,1.20158096992639,0,0,"up","yes","ERRFI1","protein_coding","chr1:8004404-8026308:-","gi|10047086|ref|NP_061821.1|",2143,0,"ERBB receptor feedback inhibitor 1 [Homo sapiens]","gi|209954668|ref|NM_018948.3|",3104,0,"Homo sapiens ERBB receptor feedback inhibitor 1 (ERRFI1), mRNA","Q9UJM3",830,0,"ERBB receptor feedback inhibitor 1",".",".",".",".","pfam11555","Inhibitor_Mig-6","EGFR receptor inhibitor Mig-6. When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.","GO:0071474|cellular hyperosmotic response;GO:0071549|cellular response to dexamethasone stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0032869|cellular response to insulin stimulus;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0048286|lung alveolus development;GO:0060428|lung epithelium development;GO:0060426|lung vasculature development;GO:1903243|negative regulation of cardiac muscle hypertrophy in response to stress;GO:0032966|negative regulation of collagen biosynthetic process;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0032691|negative regulation of interleukin-1 beta production;GO:0031953|negative regulation of protein autophosphorylation;GO:0042536|negative regulation of tumor necrosis factor biosynthetic process;GO:0045616|regulation of keratinocyte differentiation;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0043589|skin morphogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0005634|nucleus;","GO:0005096|GTPase activator activity;GO:0019901|protein kinase binding;GO:0017124|SH3 domain binding;GO:0031267|small GTPase binding;",".","."]
["ENSG00000125089",916,907,799,675.336212012708,370,435,552,2.29924797808229,1.20116207173531,5.25655898027354e-51,1.5574271829726e-49,"up","yes","SH3TC1","protein_coding","chr4:8182072-8241803:+","gi|18676534|dbj|BAB84919.1|",3908,0,"FLJ00164 protein [Homo sapiens]","gi|18676533|dbj|AK074093.1|",5799,0,"Homo sapiens mRNA for FLJ00164 protein",".",".",".",".",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSG00000114796",1016,976,883,739.755498326545,381,483,630,2.29860167511622,1.20075648296642,3.10467484191805e-55,1.00138743061731e-53,"up","yes","KLHL24","protein_coding","chr3:183635568-183684477:+","gi|26381170|dbj|BAB29759.2|",3238,0,"unnamed protein product [Mus musculus]","gi|530374819|ref|XM_005247552.1|",7380,0,"PREDICTED: Homo sapiens kelch-like family member 24 (KLHL24), transcript variant X1, mRNA","Q6TFL4",1220,0,"Kelch-like protein 24",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0045109|intermediate filament organization;GO:0051865|protein autoubiquitination;GO:0016567|protein ubiquitination;GO:2000312|regulation of kainate selective glutamate receptor activity;","GO:0005912|adherens junction;GO:0030424|axon;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0005737|cytoplasm;GO:0030057|desmosome;GO:0043204|perikaryon;",".","K10461","KLHL24_35; kelch-like protein 24/35"]
["ENSG00000075290",37,31,28,24.7622213361581,18,12,19,2.29611504370769,1.19919492808877,0.00306574258922793,0.00913659503415148,"up","yes","WNT8B","protein_coding","chr10:100463041-100483744:+","gi|110735437|ref|NP_003384.2|",1677,0,"protein Wnt-8b precursor [Homo sapiens]","gi|694941383|ref|XM_521584.3|",2064,0,"PREDICTED: Pan troglodytes wingless-type MMTV integration site family, member 8B (WNT8B), transcript variant X2, mRNA","Q93098",650,0,"Protein Wnt-8b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0060070|canonical Wnt signaling pathway;GO:0045165|cell fate commitment;GO:0071300|cellular response to retinoic acid;GO:0048263|determination of dorsal identity;GO:0007369|gastrulation;GO:0007399|nervous system development;GO:0030182|neuron differentiation;GO:0032355|response to estradiol;GO:0032526|response to retinoic acid;GO:0007165|signal transduction;GO:0016055|Wnt signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005109|frizzled binding;GO:0048018|receptor agonist activity;","K00714","WNT8; wingless-type MMTV integration site family, member 8"]
["ENSG00000074527",4038,3887,3715,3002.66687374269,1623,1934,2499,2.29178816806664,1.1964737007252,2.50425429483854e-173,3.60463110737655e-171,"up","yes","NTN4","protein_coding","chr12:95657807-95791152:-","gi|93204871|ref|NP_067052.2|",3246,0,"netrin-4 precursor [Homo sapiens]","gi|93204870|ref|NM_021229.3|",3615,0,"Homo sapiens netrin 4 (NTN4), mRNA","Q9HB63",1254,0,"Netrin-4",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0007411|axon guidance;GO:0016322|neuron remodeling;GO:0060668|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling;","GO:0005604|basement membrane;GO:0005886|plasma membrane;","GO:0043237|laminin-1 binding;","K06845","NTN4; netrin 4"]
["ENSG00000124107",20,20,30,18.1755686890181,8,13,16,2.28948729870544,1.1950245614537,0.0117475562839113,0.0307820765662385,"up","yes","SLPI","protein_coding","chr20:45252239-45254564:-","gi|4507065|ref|NP_003055.1|",674,2e-87,"antileukoproteinase precursor [Homo sapiens]","gi|519666812|ref|NM_003064.3|",596,0,"Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA","P03973",264,5e-89,"Antileukoproteinase",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0019731|antibacterial humoral response;GO:0006955|immune response;GO:0045087|innate immune response;GO:0035821|modification of morphology or physiology of other organism;GO:0032091|negative regulation of protein binding;GO:0045071|negative regulation of viral genome replication;GO:0043312|neutrophil degranulation;GO:0032496|response to lipopolysaccharide;","GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0035580|specific granule lumen;","GO:0003677|DNA binding;GO:0004866|endopeptidase inhibitor activity;GO:0019899|enzyme binding;GO:0003729|mRNA binding;GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSG00000055732",711,584,598,488.131880646165,268,324,393,2.28284831913352,1.19083500476471,1.23193425076068e-36,2.60829284617695e-35,"up","yes","MCOLN3","protein_coding","chr1:85018082-85048499:-","gi|119593624|gb|EAW73218.1|",1661,0,"mucolipin 3, isoform CRA_d [Homo sapiens]","gi|38174237|gb|BC060765.1|",2946,0,"Homo sapiens mucolipin 3, mRNA (cDNA clone MGC:71509 IMAGE:30340464), complete cds","Q8TDD5",630,0,"Mucolipin-3",".",".",".",".","pfam06060","Mesothelin","Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin). This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known.","GO:0070588|calcium ion transmembrane transport;GO:0042491|auditory receptor cell differentiation;GO:0007626|locomotory behavior;","GO:0000421|autophagosome membrane;GO:0031901|early endosome membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;","GO:0005262|calcium channel activity;GO:0008289|lipid binding;","K04994","MCOLN3; mucolipin 3"]
["ENSG00000203666",133,113,102,89.2100407928859,39,46,101,2.27987685076533,1.18895589825473,5.07851427704184e-07,2.55288984559768e-06,"up","yes","EFCAB2","protein_coding","chr1:244969705-245127164:+","gi|74756857|sp|Q5VUJ9.1|EFCB2_HUMAN",1250,3e-154,"RecName: Full=EF-hand calcium-binding domain-containing protein 2","gi|594542591|ref|NG_034030.1|",5247,0,"Homo sapiens EF-hand calcium binding domain 2 (EFCAB2), RefSeqGene on chromosome 1","Q5VUJ9",486,1e-155,"Dynein regulatory complex protein 8","YBR109c",65.5,1e-10,"COG5126","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0031514|motile cilium;","GO:0005509|calcium ion binding;",".","."]
["ENSG00000116016",3264,3069,3006,2411.67760423913,1230,1642,2025,2.27962279548044,1.18879512434161,6.823360910699e-138,6.89052278772577e-136,"up","yes","EPAS1","protein_coding","chr2:46293667-46386703:+","gi|332227348|ref|XP_003262854.1|",4363,0,"PREDICTED: endothelial PAS domain-containing protein 1 [Nomascus leucogenys]","gi|262527236|ref|NM_001430.4|",5166,0,"Homo sapiens endothelial PAS domain protein 1 (EPAS1), mRNA","Q99814",1675,0,"Endothelial PAS domain-containing protein 1",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0001525|angiogenesis;GO:0001974|blood vessel remodeling;GO:0048469|cell maturation;GO:0071456|cellular response to hypoxia;GO:0001892|embryonic placenta development;GO:0030218|erythrocyte differentiation;GO:0055072|iron ion homeostasis;GO:0030324|lung development;GO:0007005|mitochondrion organization;GO:0048625|myoblast fate commitment;GO:0042415|norepinephrine metabolic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0043687|post-translational protein modification;GO:0002027|regulation of heart rate;GO:0061418|regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0001666|response to hypoxia;GO:0007165|signal transduction;GO:0043129|surfactant homeostasis;GO:0006366|transcription from RNA polymerase II promoter;GO:0007601|visual perception;","GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0035035|histone acetyltransferase binding;GO:0046982|protein heterodimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09095","HIF2A, EPAS1; hypoxia-inducible factor 2 alpha"]
["ENSG00000135919",1624,1640,1549,1245.48609281846,686,806,1029,2.27510281129024,1.1859317417892,1.82078241266314e-81,9.05135339573366e-80,"up","yes","SERPINE2","protein_coding","chr2:223975112-224039319:-","gi|119618897|gb|EAW98491.1|",284,9e-26,"hCG2042307 [Homo sapiens]","gi|34366616|emb|BX647459.1|",5951,0,"Homo sapiens mRNA; cDNA DKFZp686A13110 (from clone DKFZp686A13110)","Q86U02",89.4,1e-18,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000102057",85,57,65,53.2324110169772,24,40,45,2.26952867089181,1.18239271391677,2.29394730199854e-05,9.57490923197311e-05,"up","yes","KCND1","protein_coding","chrX:48961378-48971569:-","gi|27436981|ref|NP_004970.3|",2954,0,"potassium voltage-gated channel subfamily D member 1 precursor [Homo sapiens]","gi|531990807|ref|NM_004979.5|",4437,0,"Homo sapiens potassium voltage-gated channel subfamily D member 1 (KCND1), mRNA","Q9NSA2",1142,0,"Potassium voltage-gated channel subfamily D member 1","STM1741",106,1e-23,"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;GO:0034765|regulation of ion transmembrane transport;","GO:0030425|dendrite;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0005250|A-type (transient outward) potassium channel activity;GO:0046872|metal ion binding;","K04891","KCND1; potassium voltage-gated channel Shal-related subfamily D member 1"]
["ENSG00000135842",7362,6918,6499,5375.86795811795,2997,3604,4275,2.26777467380599,1.1812773011567,1.5380605329981e-248,3.85274176109966e-246,"up","yes","FAM129A","protein_coding","chr1:184790724-184974550:-","gi|16757970|ref|NP_443198.1|",4496,0,"protein Niban [Homo sapiens]","gi|503774441|ref|NM_052966.3|",6928,0,"Homo sapiens family with sequence similarity 129 member A (FAM129A), mRNA","Q9BZQ8",1736,0,"Protein Niban",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0045727|positive regulation of translation;GO:0034976|response to endoplasmic reticulum stress;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000197558",46,36,48,33.621988332963,12,31,26,2.26636095086322,1.18037764957428,0.00102565193761521,0.00335187641015287,"up","yes","SSPO","protein_coding","chr7:149776042-149833979:+","gi|134031945|ref|NP_940857.2|",6348,0,"SCO-spondin precursor [Homo sapiens]","gi|134031944|ref|NM_198455.2|",8969,0,"Homo sapiens SCO-spondin (SSPO), mRNA","A2VEC9",2456,0,"SCO-spondin",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0007155|cell adhesion;GO:0030154|cell differentiation;GO:0007399|nervous system development;","GO:0005615|extracellular space;","GO:0030414|peptidase inhibitor activity;",".","."]
["ENSG00000169031",36,16,38,23.3747465588958,13,18,16,2.26300828140925,1.17824186411263,0.00771370421861555,0.0210173650188807,"up","yes","COL4A3","protein_coding","chr2:227164565-227314792:+","gi|3702452|emb|CAA56335.1|",1800,0,"type IV collagen alpha 3 chain [Homo sapiens]","gi|297632355|ref|NM_000091.4|",8097,0,"Homo sapiens collagen type IV alpha 3 (COL4A3), mRNA","Q01955",665,0,"Collagen alpha-3(IV) chain",".",".",".",".","pfam01413","C4","C-terminal tandem repeated domain in type 4 procollagen. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008015|blood circulation;GO:0007155|cell adhesion;GO:0008283|cell proliferation;GO:0007166|cell surface receptor signaling pathway;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0072577|endothelial cell apoptotic process;GO:0030198|extracellular matrix organization;GO:0032836|glomerular basement membrane development;GO:0016525|negative regulation of angiogenesis;GO:0008285|negative regulation of cell proliferation;GO:0007605|sensory perception of sound;","GO:0005604|basement membrane;GO:0005587|collagen type IV trimer;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0043231|intracellular membrane-bounded organelle;","GO:0005201|extracellular matrix structural constituent;GO:0005178|integrin binding;GO:0008191|metalloendopeptidase inhibitor activity;GO:0005198|structural molecule activity;","K06237","COL4A; collagen, type IV, alpha"]
["ENSG00000155085",55,57,65,46.0117865009907,26,25,43,2.26147240197952,1.17726239005722,8.18846250362366e-05,0.000315814966546477,"up","yes","AK9","protein_coding","chr6:109492856-109691217:-","gi|767942168|ref|XP_006715439.2|",8613,0,"PREDICTED: adenylate kinase 9 isoform X2 [Homo sapiens]","gi|237858798|ref|NM_001145128.2|",6326,0,"Homo sapiens adenylate kinase 9 (AK9), transcript variant 1, mRNA","Q5TCS8",3314,0,"Adenylate kinase 9","FN1298",75.9,9e-14,"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0006756|AMP phosphorylation;GO:0006757|ATP generation from ADP;GO:0061508|CDP phosphorylation;GO:0061566|CMP phosphorylation;GO:0006174|dADP phosphorylation;GO:0061565|dAMP phosphorylation;GO:0061570|dCDP phosphorylation;GO:0061567|dCMP phosphorylation;GO:0006186|dGDP phosphorylation;GO:0061568|GDP phosphorylation;GO:0015949|nucleobase-containing small molecule interconversion;GO:0061571|TDP phosphorylation;GO:0061569|UDP phosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031965|nuclear membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004550|nucleoside diphosphate kinase activity;GO:0019206|nucleoside kinase activity;GO:0050145|nucleoside phosphate kinase activity;","K18533","AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6]"]
["ENSG00000245532",7700,6044,5817,5046.33399235221,2890,3558,3700,2.26122653544946,1.17710553220358,1.26003654272907e-25,1.90317813908836e-24,"up","yes","NEAT1","lincRNA","chr11:65422774-65445540:+","gi|119594794|gb|EAW74388.1|",486,2e-51,"hCG2018833 [Homo sapiens]","gi|764020159|ref|NR_131012.1|",22743,0,"Homo sapiens nuclear paraspeckle assembly transcript 1 (non-protein coding) (NEAT1), transcript variant MENbeta, long non-coding RNA","O00370",125,1e-28,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["ENSG00000175061",5781,5499,4990,4209.53727924861,2255,2767,3564,2.26009225747562,1.17638166497938,4.38362048267539e-202,8.20886134658669e-200,"up","yes","LRRC75A-AS1","processed_transcript","chr17:16438822-16478678:+","gi|119624920|gb|EAX04515.1|",248,2e-22,"chromosome 17 open reading frame 45, isoform CRA_f, partial [Homo sapiens]","gi|18308345|gb|AC093484.2|",931,0,"Homo sapiens chromosome , clone RP11-138I1, complete sequence","Q8N1F1",65.1,6e-11,"Putative uncharacterized protein LRRC75A-AS1, mitochondrial",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005739|mitochondrion;",".",".","."]
["ENSG00000169122",42,58,42,36.743577874559,15,27,34,2.25972698888104,1.17614848256105,0.000504035203512537,0.00173263785516839,"up","yes","FAM110B","protein_coding","chr8:57994509-58204279:+","gi|148673748|gb|EDL05695.1|",1644,0,"RIKEN cDNA 1700012H17, isoform CRA_c, partial [Mus musculus]","gi|83281205|ref|NM_147189.2|",3438,0,"Homo sapiens family with sequence similarity 110 member B (FAM110B), mRNA","Q8TC76",624,0,"Protein FAM110B",".",".",".",".","pfam14160","FAM110_C","Centrosome-associated C terminus. This is the C-terminus of a family of proteins that colocalize with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.",".","GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0005739|mitochondrion;",".",".","."]
["ENSG00000109814",2058,1996,1789,1513.76236809877,861,1014,1192,2.25903648193874,1.17570756948581,3.77161075071014e-93,2.25222378203397e-91,"up","yes","UGDH","protein_coding","chr4:39498755-39528311:-","gi|530376515|ref|XP_005262724.1|",2663,0,"PREDICTED: UDP-glucose 6-dehydrogenase isoform X1 [Homo sapiens]","gi|296040435|ref|NM_003359.3|",3195,0,"Homo sapiens UDP-glucose 6-dehydrogenase (UGDH), transcript variant 1, mRNA","O60701",1026,0,"UDP-glucose 6-dehydrogenase","SMc02641",288,2e-85,"COG1004","pfam03721","UDPG_MGDP_dh_N","UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain. The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.","GO:0001702|gastrulation with mouth forming second;GO:0006024|glycosaminoglycan biosynthetic process;GO:0006011|UDP-glucose metabolic process;GO:0006065|UDP-glucuronate biosynthetic process;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0009055|electron carrier activity;GO:0051287|NAD binding;GO:0003979|UDP-glucose 6-dehydrogenase activity;","K00012","UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]"]
["ENSG00000151773",177,154,156,125.827258134229,62,80,117,2.25734515600584,1.17462702853706,6.32002971830084e-11,4.54470210682336e-10,"up","yes","CCDC122","protein_coding","chr13:43823909-43879727:-","gi|767977327|ref|XP_011533245.1|",1341,7e-173,"PREDICTED: coiled-coil domain-containing protein 122 isoform X1 [Homo sapiens]","gi|16551805|dbj|AK056408.1|",3436,0,"Homo sapiens cDNA FLJ31846 fis, clone NT2RP7000425, weakly similar to MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B","O00370",292,3e-148,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["ENSG00000168297",2216,2146,2054,1664.97715279133,897,1097,1414,2.24690834048441,1.16794127297098,5.3636145177279e-106,3.80343370654175e-104,"up","yes","PXK","protein_coding","chr3:58332880-58426126:+","gi|31543452|ref|NP_060241.2|",2597,0,"PX domain-containing protein kinase-like protein isoform 1 [Homo sapiens]","gi|574273241|ref|NM_001289098.1|",3035,0,"Homo sapiens PX domain containing serine/threonine kinase like (PXK), transcript variant 4, mRNA","Q7Z7A4",1003,0,"PX domain-containing protein kinase-like protein",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0006954|inflammatory response;GO:0050804|modulation of synaptic transmission;GO:0032780|negative regulation of ATPase activity;GO:0043271|negative regulation of ion transport;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0003779|actin binding;GO:0035091|phosphatidylinositol binding;GO:0008022|protein C-terminus binding;","K17543","PXK; PX domain-containing protein kinase-like protein"]
["ENSG00000023839",115,118,98,86.2623593632164,60,58,54,2.24313507691785,1.16551649912768,3.19305494128168e-07,1.63449160582381e-06,"up","yes","ABCC2","protein_coding","chr10:99782640-99852594:+","gi|308153583|sp|Q92887.3|MRP2_HUMAN",7590,0,"RecName: Full=Canalicular multispecific organic anion transporter 1; AltName: Full=ATP-binding cassette sub-family C member 2; AltName: Full=Canalicular multidrug resistance protein; AltName: Full=Multidrug resistance-associated protein 2","gi|594191052|ref|NM_000392.4|",5401,0,"Homo sapiens ATP binding cassette subfamily C member 2 (ABCC2), mRNA","Q92887",2924,0,"Canalicular multispecific organic anion transporter 1","YDR135c",946,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:1901086|benzylpenicillin metabolic process;GO:0015722|canalicular bile acid transport;GO:0030644|cellular chloride ion homeostasis;GO:0071549|cellular response to dexamethasone stimulus;GO:0032870|cellular response to hormone stimulus;GO:0071347|cellular response to interleukin-1;GO:0071354|cellular response to interleukin-6;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0006855|drug transmembrane transport;GO:0007565|female pregnancy;GO:0015694|mercury ion transport;GO:0015732|prostaglandin transport;GO:0046685|response to arsenic-containing substance;GO:0043627|response to estrogen;GO:0033762|response to glucagon;GO:0009408|response to heat;GO:0031427|response to methotrexate;GO:0006979|response to oxidative stress;GO:0070327|thyroid hormone transport;GO:0055085|transmembrane transport;","GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0009986|cell surface;GO:0005887|integral component of plasma membrane;GO:0046581|intercellular canaliculus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0015127|bilirubin transmembrane transporter activity;GO:0008514|organic anion transmembrane transporter activity;GO:0019904|protein domain specific binding;","K05666","ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2"]
["ENSG00000274180",269,250,206,187.145551566774,82,123,186,2.24024881044937,1.16365897231284,4.51657106384406e-13,3.73406012342153e-12,"up","yes","NATD1","protein_coding","chr17:21238870-21253410:-","gi|116325985|ref|NP_690878.2|",586,3e-66,"protein NATD1 [Homo sapiens]","gi|116325984|ref|NM_152914.2|",4787,0,"Homo sapiens N-acetyltransferase domain containing 1 (NATD1), mRNA","Q8N6N6",230,9e-68,"Protein NATD1","PA1749",51.2,3e-06,"COG2388","pfam14542","Acetyltransf_CG","GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.",".",".",".","K06975","K06975; uncharacterized protein"]
["ENSG00000168899",21,27,30,20.4064143525793,12,10,20,2.23859071426039,1.16259078165977,0.00953418259921356,0.0254315190117039,"up","yes","VAMP5","protein_coding","chr2:85584408-85593412:+","gi|5730112|ref|NP_006625.1|",483,3e-58,"vesicle-associated membrane protein 5 [Homo sapiens]","gi|426336216|ref|XM_004029548.1|",674,0,"PREDICTED: Gorilla gorilla gorilla vesicle-associated membrane protein 5 (VAMP5), mRNA","O95183",190,9e-60,"Vesicle-associated membrane protein 5",".",".",".",".","pfam00957","Synaptobrevin","Synaptobrevin.","GO:0030154|cell differentiation;GO:0006887|exocytosis;GO:0043001|Golgi to plasma membrane protein transport;GO:0007517|muscle organ development;GO:0007519|skeletal muscle tissue development;GO:0006906|vesicle fusion;","GO:0009986|cell surface;GO:0030659|cytoplasmic vesicle membrane;GO:0070062|extracellular exosome;GO:0005794|Golgi apparatus;GO:0031301|integral component of organelle membrane;GO:0005887|integral component of plasma membrane;GO:0014704|intercalated disc;GO:0005770|late endosome;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0031201|SNARE complex;","GO:0005484|SNAP receptor activity;GO:0000149|SNARE binding;","K08514","VAMP5; vesicle-associated membrane protein 5"]
["ENSG00000284747",27,24,26,19.9073930419209,7,14,21,2.23486738107153,1.16018922319959,0.00966584414376631,0.0257513007153192,"up","yes","AL034417.4","antisense","chr1:7991134-8005312:+","gi|355756662|gb|EHH60270.1|",349,2e-35,"hypothetical protein EGM_11598, partial [Macaca fascicularis]","gi|5102616|emb|AL034417.14|",1189,0,"Human DNA sequence from clone CTA-215D11 on chromosome 1p36.12-36.33, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000162669",23,30,23,19.8857497851621,13,14,13,2.23231141297023,1.15853830073742,0.00967321101905939,0.0257631723468127,"up","yes","HFM1","protein_coding","chr1:91260766-91404869:-","gi|767902756|ref|XP_011539151.1|",7612,0,"PREDICTED: probable ATP-dependent DNA helicase HFM1 isoform X1 [Homo sapiens]","gi|615276311|ref|NM_001017975.4|",4922,0,"Homo sapiens HFM1, ATP-dependent DNA helicase homolog (HFM1), mRNA","A2PYH4",2936,0,"Probable ATP-dependent DNA helicase HFM1","YGL251c",447,3e-132,"COG1204","pfam02889","Sec63","Sec63 Brl domain. This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.","GO:0000712|resolution of meiotic recombination intermediates;GO:0010501|RNA secondary structure unwinding;","GO:0005737|cytoplasm;GO:0005730|nucleolus;","GO:0005524|ATP binding;GO:0004004|ATP-dependent RNA helicase activity;GO:0003676|nucleic acid binding;","K15271","HFM1, MER3; ATP-dependent DNA helicase HFM1/MER3 [EC:3.6.4.12]"]
["ENSG00000136826",1613,1519,1527,1212.20871153947,676,781,1032,2.2319669288932,1.15831565087891,8.40543803379884e-77,3.94462503153071e-75,"up","yes","KLF4","protein_coding","chr9:107484852-107490482:-","gi|218563721|ref|NP_001136265.1|",1974,0,"Krueppel-like factor 4 [Macaca mulatta]","gi|930697453|ref|NM_004235.5|",2813,0,"Homo sapiens Kruppel-like factor 4 (gut) (KLF4), transcript variant 2, mRNA","O43474",745,0,"Krueppel-like factor 4",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0060070|canonical Wnt signaling pathway;GO:0071409|cellular response to cycloheximide;GO:0071363|cellular response to growth factor stimulus;GO:0070301|cellular response to hydrogen peroxide;GO:0071499|cellular response to laminar fluid shear stress;GO:1990830|cellular response to leukemia inhibitory factor;GO:1901653|cellular response to peptide;GO:0071300|cellular response to retinoic acid;GO:0009913|epidermal cell differentiation;GO:0048730|epidermis morphogenesis;GO:0045444|fat cell differentiation;GO:0007500|mesodermal cell fate determination;GO:0016525|negative regulation of angiogenesis;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;GO:0008285|negative regulation of cell proliferation;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:0010629|negative regulation of gene expression;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0050728|negative regulation of inflammatory response;GO:0045415|negative regulation of interleukin-8 biosynthetic process;GO:0014740|negative regulation of muscle hyperplasia;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0051898|negative regulation of protein kinase B signaling;GO:0060761|negative regulation of response to cytokine stimulus;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032270|positive regulation of cellular protein metabolic process;GO:0010628|positive regulation of gene expression;GO:0046985|positive regulation of hemoglobin biosynthetic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0051247|positive regulation of protein metabolic process;GO:1903672|positive regulation of sprouting angiogenesis;GO:0051973|positive regulation of telomerase activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0031077|post-embryonic camera-type eye development;GO:0035166|post-embryonic hemopoiesis;GO:0061614|pri-miRNA transcription from RNA polymerase II promoter;GO:0048679|regulation of axon regeneration;GO:0045595|regulation of cell differentiation;GO:0035019|somatic stem cell population maintenance;GO:0019827|stem cell population maintenance;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0000790|nuclear chromatin;GO:0005719|nuclear euchromatin;GO:0044798|nuclear transcription factor complex;GO:0005654|nucleoplasm;","GO:0008013|beta-catenin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042826|histone deacetylase binding;GO:0035014|phosphatidylinositol 3-kinase regulator activity;GO:1990841|promoter-specific chromatin binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0001221|transcription cofactor binding;GO:0001010|transcription factor activity, sequence-specific DNA binding transcription factor recruiting;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001190|transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0008270|zinc ion binding;","K17846","KLF4; krueppel-like factor 4"]
["ENSG00000205363",59,41,49,38.7274003376646,24,24,31,2.22946629331691,1.15669838811016,0.00031703263380045,0.00112717519645034,"up","yes","INSYN1","protein_coding","chr15:73735431-73752747:-","gi|55642909|ref|XP_510662.1|",1303,7e-161,"PREDICTED: UPF0583 protein C15orf59 homolog [Pan troglodytes]","gi|767984087|ref|XM_005254369.3|",6573,0,"PREDICTED: Homo sapiens chromosome 15 open reading frame 59 (C15orf59), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15252","DUF4589","Domain of unknown function (DUF4589). This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.",".",".",".",".","."]
["ENSG00000197808",43,44,49,35.4888241891277,17,28,28,2.22924088663386,1.1565525193231,0.000549108734335997,0.00187587836837987,"up","yes","ZNF461","protein_coding","chr19:36637192-36666853:-","gi|530417554|ref|XP_005259460.1|",2767,0,"PREDICTED: zinc finger protein 461 isoform X2 [Homo sapiens]","gi|768012020|ref|XM_005259403.2|",3326,0,"PREDICTED: Homo sapiens zinc finger protein 461 (ZNF461), transcript variant X2, mRNA","Q8TAF7",1045,0,"Zinc finger protein 461",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000157693",860,854,743,638.967405465427,335,454,528,2.22331399781286,1.15271171404067,7.94096117177089e-44,2.02331914241898e-42,"up","yes","TMEM268","protein_coding","chr9:114611206-114646422:+","gi|578817162|ref|XP_006717060.1|",1508,0,"PREDICTED: transmembrane protein C9orf91 isoform X4 [Homo sapiens]","gi|578817161|ref|XM_006716997.1|",4358,0,"PREDICTED: Homo sapiens chromosome 9 open reading frame 91 (C9orf91), transcript variant X5, mRNA","Q5VZI3",579,0,"Transmembrane protein 268",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000085831",101,81,103,74.2809919206084,37,57,59,2.22324438827707,1.15266654412571,1.08541337666521e-06,5.27607187729801e-06,"up","yes","TTC39A","protein_coding","chr1:51287258-51345116:-","gi|3413866|dbj|BAA32297.1|",2212,0,"KIAA0452 protein [Homo sapiens]","gi|3413865|dbj|AB007921.1|",6216,0,"Homo sapiens mRNA for KIAA0452 protein, partial cds",".",".",".",".",".",".",".",".","pfam10300","DUF3808","Protein of unknown function (DUF3808). This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain pfam07719 at their C-terminus.",".",".",".",".","."]
["ENSG00000145476",1226,995,1023,843.919377401572,483,574,675,2.219512441226,1.15024279554958,2.87060930551779e-51,8.55769896210619e-50,"up","yes","CYP4V2","protein_coding","chr4:186191520-186213456:+","gi|578809044|ref|XP_006714247.1|",953,5e-111,"PREDICTED: cytochrome P450 4V2 isoform X2 [Homo sapiens]","gi|34367894|emb|BX648730.1|",7890,0,"Homo sapiens mRNA; cDNA DKFZp451K0110 (from clone DKFZp451K0110)","Q6ZWL3",371,1e-110,"Cytochrome P450 4V2","BH0579",142,5e-34,"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0010430|fatty acid omega-oxidation;GO:0050896|response to stimulus;GO:0001523|retinoid metabolic process;GO:0016125|sterol metabolic process;GO:0007601|visual perception;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;","K07427","CYP4V; cytochrome P450, family 4, subfamily V"]
["ENSG00000235448",42,30,41,29.426650827341,16,18,27,2.21774129741457,1.1490910829455,0.00179675964620072,0.00561320052735982,"up","yes","LURAP1L-AS1","antisense","chr9:12698554-12814345:-","gi|1067130|emb|CAA35820.1|",177,4e-12,"melanoma antigen gp 75 [Homo sapiens]","gi|225703119|ref|NG_011705.1|",802,0,"Homo sapiens tyrosinase-related protein 1 (TYRP1), RefSeqGene on chromosome 9","P17643",72.8,7e-13,"5,6-dihydroxyindole-2-carboxylic acid oxidase",".",".",".",".","pfam13268","DUF4059","Protein of unknown function (DUF4059). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DKT sequence motif.","GO:0043438|acetoacetic acid metabolic process;GO:0042438|melanin biosynthetic process;GO:0030318|melanocyte differentiation;GO:0032438|melanosome organization;GO:0048023|positive regulation of melanin biosynthetic process;","GO:0030669|clathrin-coated endocytic vesicle membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0042470|melanosome;GO:0033162|melanosome membrane;","GO:0046872|metal ion binding;GO:0004497|monooxygenase activity;GO:0016491|oxidoreductase activity;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;","K00506","TYRP1; tyrosinase-related protein 1 [EC:1.14.18.-]"]
["ENSG00000198768",201,173,164,139.945059060997,76,97,116,2.21388114178004,1.14657776919828,7.27583572e-12,5.5707571632767e-11,"up","yes","APCDD1L","protein_coding","chr20:58459101-58515131:-","gi|23503291|ref|NP_699191.1|",2347,0,"protein APCDD1-like isoform 1 precursor [Homo sapiens]","gi|755571525|ref|NM_153360.2|",3426,0,"Homo sapiens adenomatosis polyposis coli down-regulated 1-like (APCDD1L), transcript variant 1, mRNA","Q8NCL9",910,0,"Protein APCDD1-like",".",".",".",".","pfam14921","APCDDC","Adenomatosis polyposis coli down-regulated 1. The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo. APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region. The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000144802",728,615,625,512.387248278958,290,325,444,2.21292940030247,1.14595742517497,2.84670514678913e-35,5.85365126559369e-34,"up","yes","NFKBIZ","protein_coding","chr3:101827991-101861022:+","gi|13899229|ref|NP_113607.1|",3459,0,"NF-kappa-B inhibitor zeta isoform a [Homo sapiens]","gi|299890851|ref|NM_031419.3|",3923,0,"Homo sapiens NFKB inhibitor zeta (NFKBIZ), transcript variant 1, mRNA","Q9BYH8",1335,0,"NF-kappa-B inhibitor zeta","PAE1861",57.8,5e-08,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006954|inflammatory response;GO:2000321|positive regulation of T-helper 17 cell differentiation;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0050852|T cell receptor signaling pathway;GO:0006351|transcription, DNA-templated;","GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0016607|nuclear speck;GO:0005634|nucleus;","GO:0003712|transcription cofactor activity;","K14242","NFKBIZ; NF-kappa-B inhibitor zeta"]
["ENSG00000258102",139,103,115,93.1065854477512,55,71,64,2.21017667192664,1.14416169700359,9.77488309363577e-08,5.27231390128766e-07,"up","yes","MAP1LC3B2","protein_coding","chr12:116548105-116576448:+",".",".",".",".","gi|767976745|ref|XR_945397.1|",732,0,"PREDICTED: Homo sapiens uncharacterized LOC105370009 (LOC105370009), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam14707","Sulfatase_C","C-terminal region of aryl-sulfatase.",".",".",".",".","."]
["ENSG00000183696",3130,3099,2912,2384.18402966356,1281,1559,2110,2.20976006289646,1.14388972940782,3.45737081681004e-114,2.73302329158328e-112,"up","yes","UPP1","protein_coding","chr7:48088628-48108733:+","gi|566006090|ref|NP_001274357.1|",861,7e-106,"uridine phosphorylase 1 isoform b [Homo sapiens]","gi|21755588|dbj|AK096167.1|",2767,0,"Homo sapiens cDNA FLJ38848 fis, clone MESAN2008334, highly similar to URIDINE PHOSPHORYLASE (EC 2.4.2.3)","Q16831",336,2e-105,"Uridine phosphorylase 1","ML2177",72,1e-12,"COG2820","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0042149|cellular response to glucose starvation;GO:0006139|nucleobase-containing compound metabolic process;GO:0009166|nucleotide catabolic process;GO:0046135|pyrimidine nucleoside catabolic process;GO:0043097|pyrimidine nucleoside salvage;GO:0044206|UMP salvage;GO:0006218|uridine catabolic process;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0004850|uridine phosphorylase activity;","K00757","udp, UPP; uridine phosphorylase [EC:2.4.2.3]"]
["ENSG00000172748",33,30,27,23.6160992097846,19,15,13,2.20846877663261,1.14304643567636,0.00658522149441146,0.0182493896816391,"up","yes","ZNF596","protein_coding","chr8:232137-264703:+","gi|109240540|ref|NP_775810.2|",2686,0,"zinc finger protein 596 isoform 1 [Homo sapiens]","gi|564730625|ref|NM_001042416.2|",2863,0,"Homo sapiens zinc finger protein 596 (ZNF596), transcript variant 1, mRNA","Q8TC21",1039,0,"Zinc finger protein 596",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000197653",39,20,26,21.977096479441,13,10,23,2.20799522947948,1.14273705508088,0.00978586536569033,0.0260380426504946,"up","yes","DNAH10","protein_coding","chr12:123762188-123936206:+","gi|530401632|ref|XP_005253612.1|",23376,0,"PREDICTED: dynein heavy chain 10, axonemal isoform X5 [Homo sapiens]","gi|198442843|ref|NM_207437.3|",13680,0,"Homo sapiens dynein axonemal heavy chain 10 (DNAH10), mRNA","Q8IVF4",8958,0,"Dynein heavy chain 10, axonemal","YKR054c",417,2e-115,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0007018|microtubule-based movement;","GO:0005929|cilium;GO:0005737|cytoplasm;GO:0030286|dynein complex;GO:0005874|microtubule;","GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0045503|dynein light chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein heavy chain, axonemal"]
["ENSG00000272669",41,28,32,26.3078364194019,15,20,19,2.20587525751498,1.14135120867501,0.00322284805943099,0.00955461010917689,"up","yes","AL021707.6","antisense","chr22:38742625-38743115:+",".",".",".",".","gi|551893078|tpe|HG512301.1|",491,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000472390.1 (RP3-508I15.21 gene), antisense",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSG00000181722",147,112,109,95.8414425769347,58,65,74,2.20330217672991,1.13966737019711,3.48999037873526e-08,1.96769758623343e-07,"up","yes","ZBTB20","protein_coding","chr3:114314501-115147271:-","gi|257900533|ref|NP_001157814.1|",3686,0,"zinc finger and BTB domain-containing protein 20 isoform 1 [Homo sapiens]","gi|657940864|ref|NM_015642.5|",27125,0,"Homo sapiens zinc finger and BTB domain containing 20 (ZBTB20), transcript variant 2, mRNA","Q9HC78",1424,0,"Zinc finger and BTB domain-containing protein 20",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0032728|positive regulation of interferon-beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0006351|transcription, DNA-templated;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K10501","ZBTB20, HOF, DPZF; zinc finger and BTB domain-containing protein 20"]
["ENSG00000142408",105,67,81,65.8333809643351,39,42,55,2.20318611406564,1.13959137179695,6.50404073858883e-06,2.89764279785384e-05,"up","yes","CACNG8","protein_coding","chr19:53963040-53990215:+","gi|24586686|ref|NP_114101.4|",1350,5e-164,"voltage-dependent calcium channel gamma-8 subunit [Homo sapiens]","gi|313482785|ref|NM_031895.5|",8747,0,"Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 8 (CACNG8), mRNA","Q8WXS5",524,2e-165,"Voltage-dependent calcium channel gamma-8 subunit",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0070588|calcium ion transmembrane transport;GO:0006816|calcium ion transport;GO:2000311|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:0019226|transmission of nerve impulse;","GO:0032281|AMPA glutamate receptor complex;GO:0030054|cell junction;GO:0030666|endocytic vesicle membrane;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0005891|voltage-gated calcium channel complex;","GO:0016247|channel regulator activity;GO:0005245|voltage-gated calcium channel activity;","K04873","CACNG8; voltage-dependent calcium channel gamma-8"]
["ENSG00000222009",270,211,217,181.540089034203,88,134,157,2.20082969287656,1.13804750926912,1.15884866681344e-13,9.95185800779062e-13,"up","yes","BTBD19","protein_coding","chr1:44808482-44815585:+","gi|635108632|ref|XP_007977184.1|",844,2e-102,"PREDICTED: BTB/POZ domain-containing protein 19 isoform X7 [Chlorocebus sabaeus]","gi|16551474|dbj|AK056150.1|",2319,0,"Homo sapiens cDNA FLJ31588 fis, clone NT2RI2002252",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000186480",4406,4188,4013,3292.92524452949,1840,2169,2823,2.19963999150434,1.13726742148997,7.59780126901137e-168,1.02479993620064e-165,"up","yes","INSIG1","protein_coding","chr7:155297776-155310235:+","gi|28882053|ref|NP_005533.2|",1077,2e-135,"insulin-induced gene 1 protein isoform 1 [Homo sapiens]","gi|241982792|ref|NM_005542.4|",3010,0,"Homo sapiens insulin induced gene 1 (INSIG1), transcript variant 1, mRNA","O15503",419,7e-137,"Insulin-induced gene 1 protein",".",".",".",".","pfam07281","INSIG","Insulin-induced protein (INSIG). This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.","GO:0008283|cell proliferation;GO:0036315|cellular response to sterol;GO:0006695|cholesterol biosynthetic process;GO:0042632|cholesterol homeostasis;GO:0060363|cranial suture morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:1901303|negative regulation of cargo loading into COPII-coated vesicle;GO:0045599|negative regulation of fat cell differentiation;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0070862|negative regulation of protein exit from endoplasmic reticulum;GO:0010894|negative regulation of steroid biosynthetic process;GO:0060021|palate development;GO:0032933|SREBP signaling pathway;GO:0036316|SREBP-SCAP complex retention in endoplasmic reticulum;GO:0006641|triglyceride metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0032937|SREBP-SCAP-Insig complex;",".",".","."]
["ENSG00000038945",71,76,43,49.4436258117638,29,35,38,2.19585189664021,1.13478075234486,0.000127063235432765,0.00047801749269108,"up","yes","MSR1","protein_coding","chr8:16107878-16567490:-","gi|20357515|ref|NP_619730.1|",1906,0,"macrophage scavenger receptor types I and II isoform type 3 [Homo sapiens]","gi|109148506|ref|NM_138716.2|",3572,0,"Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript variant SR-AIII, mRNA","P21757",663,0,"Macrophage scavenger receptor types I and II",".",".",".",".","pfam03523","Macscav_rec","Macrophage scavenger receptor.","GO:0097242|beta-amyloid clearance;GO:0030301|cholesterol transport;GO:0042953|lipoprotein transport;GO:0010629|negative regulation of gene expression;GO:0006911|phagocytosis, engulfment;GO:0034381|plasma lipoprotein particle clearance;GO:0010886|positive regulation of cholesterol storage;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0006898|receptor-mediated endocytosis;","GO:0005581|collagen trimer;GO:0030666|endocytic vesicle membrane;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0034362|low-density lipoprotein particle;GO:0005886|plasma membrane;","GO:0001540|beta-amyloid binding;GO:0030169|low-density lipoprotein particle binding;GO:0005044|scavenger receptor activity;","K06558","MSR1; macrophage scavenger receptor 1"]
["ENSG00000106853",2594,2421,2304,1912.07237412286,1059,1292,1621,2.19489149246818,1.13414961987569,3.2380927947252e-119,2.77583705887376e-117,"up","yes","PTGR1","protein_coding","chr9:111549722-111599893:-","gi|226056130|ref|NP_001139581.1|",1012,1e-143,"prostaglandin reductase 1 isoform 2 [Homo sapiens]","gi|21750429|dbj|AK091948.1|",2289,0,"Homo sapiens cDNA FLJ34629 fis, clone KIDNE2015515, highly similar to NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE (EC 1.1.1.-)","Q14914",394,5e-145,"Prostaglandin reductase 1","BS_yfmJ",137,2e-34,"COG2130","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006691|leukotriene metabolic process;GO:0097327|response to antineoplastic agent;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;","GO:0036132|13-prostaglandin reductase activity;GO:0047522|15-oxoprostaglandin 13-oxidase activity;GO:0032440|2-alkenal reductase [NAD(P)] activity;","K13948","PTGR1, LTB4DH; prostaglandin reductase 1 [EC:1.3.1.74 1.3.1.48]"]
["ENSG00000159917",141,99,88,85.2202401175296,50,60,66,2.1944822622384,1.13388060909748,5.09831370931591e-07,2.56150754949948e-06,"up","yes","ZNF235","protein_coding","chr19:44228729-44305046:-","gi|190610025|ref|NP_004225.3|",3531,0,"zinc finger protein 235 [Homo sapiens]","gi|110624567|dbj|AK226126.1|",4213,0,"Homo sapiens mRNA for zinc finger protein 93 homolog, clone: fj01894","Q14590",1364,0,"Zinc finger protein 235","SPAC144.09c",121,5e-28,"COG5048","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000136997",2613,2520,2384,1965.25437539491,1075,1346,1666,2.19273534576494,1.13273169509709,6.69070934321402e-119,5.685039727397e-117,"up","yes","MYC","protein_coding","chr8:127735434-127741434:+","gi|71774083|ref|NP_002458.2|",1904,0,"myc proto-oncogene protein [Homo sapiens]","gi|239582723|ref|NM_002467.4|",2366,0,"Homo sapiens v-myc avian myelocytomatosis viral oncogene homolog (MYC), mRNA","P01106",706,0,"Myc proto-oncogene protein",".",".",".",".","pfam01056","Myc_N","Myc amino-terminal region. The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0060070|canonical Wnt signaling pathway;GO:0007050|cell cycle arrest;GO:0006879|cellular iron ion homeostasis;GO:0006974|cellular response to DNA damage stimulus;GO:0035690|cellular response to drug;GO:0071456|cellular response to hypoxia;GO:0034644|cellular response to UV;GO:0006338|chromatin remodeling;GO:0051276|chromosome organization;GO:0019221|cytokine-mediated signaling pathway;GO:0006112|energy reserve metabolic process;GO:0070371|ERK1 and ERK2 cascade;GO:0044346|fibroblast apoptotic process;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000165|MAPK cascade;GO:0043066|negative regulation of apoptotic process;GO:0051782|negative regulation of cell division;GO:0048147|negative regulation of fibroblast proliferation;GO:0045656|negative regulation of monocyte differentiation;GO:0032873|negative regulation of stress-activated MAPK cascade;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0007219|Notch signaling pathway;GO:0015671|oxygen transport;GO:0008284|positive regulation of cell proliferation;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:2000573|positive regulation of DNA biosynthetic process;GO:0050679|positive regulation of epithelial cell proliferation;GO:0048146|positive regulation of fibroblast proliferation;GO:0010628|positive regulation of gene expression;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0090096|positive regulation of metanephric cap mesenchymal cell proliferation;GO:2001022|positive regulation of response to DNA damage stimulus;GO:0051973|positive regulation of telomerase activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0016579|protein deubiquitination;GO:0032986|protein-DNA complex disassembly;GO:0010468|regulation of gene expression;GO:0032204|regulation of telomere maintenance;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0042493|response to drug;GO:0010332|response to gamma radiation;GO:0070848|response to growth factor;","GO:0000790|nuclear chromatin;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0033613|activating transcription factor binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0070888|E-box binding;GO:0046983|protein dimerization activity;GO:0044877|macromolecular complex binding;GO:0070491|repressing transcription factor binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K04377","MYC; Myc proto-oncogene protein"]
["ENSG00000251161",32,18,22,18.7112336519791,12,9,18,2.19097340555031,1.13157197272908,0.0156226288149155,0.0397050698066677,"up","yes","AC020661.1","lincRNA","chr15:40906811-40910337:+","gi|795267226|ref|XP_011812064.1|",205,5e-14,"PREDICTED: vacuolar protein sorting-associated protein 18 homolog [Colobus angolensis palliatus]","gi|666686458|tpe|HG506932.2|",1584,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000418857.2 (RP11-540O11.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000182870",101,75,72,64.4658684944795,32,47,56,2.19005828755953,1.1309692671114,6.16081126454984e-06,2.75451385421042e-05,"up","yes","GALNT9","protein_coding","chr12:132196372-132329349:-","gi|355562358|gb|EHH18952.1|",292,1e-27,"hypothetical protein EGK_19543, partial [Macaca mulatta]","gi|45544583|gb|AC148477.3|",2532,0,"Homo sapiens 12 BAC RP13-895J2 (Roswell Park Cancer Institute Human BAC Library) complete sequence","Q86U02",105,9e-25,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000105612",1119,1048,1006,829.112708533232,443,554,735,2.18970637041443,1.13073742400531,6.0011391752216e-55,1.92916620686124e-53,"up","yes","DNASE2","protein_coding","chr19:12875211-12881468:-","gi|4503349|ref|NP_001366.1|",1745,0,"deoxyribonuclease-2-alpha precursor [Homo sapiens]","gi|58331228|ref|NM_001375.2|",1955,0,"Homo sapiens deoxyribonuclease II, lysosomal (DNASE2), mRNA","O00115",676,0,"Deoxyribonuclease-2-alpha",".",".",".",".","pfam03265","DNase_II","Deoxyribonuclease II.","GO:0006309|apoptotic DNA fragmentation;GO:0006259|DNA metabolic process;GO:0030218|erythrocyte differentiation;","GO:0070062|extracellular exosome;GO:0005622|intracellular;GO:0005764|lysosome;","GO:0004531|deoxyribonuclease II activity;GO:0003677|DNA binding;","K01158","DNASE2; deoxyribonuclease II [EC:3.1.22.1]"]
["ENSG00000103723",25,35,41,26.7383434308674,15,21,19,2.18834729970331,1.12984171792865,0.00453248665704765,0.013020941710029,"up","yes","AP3B2","protein_coding","chr15:82659281-82709914:-","gi|149057365|gb|EDM08688.1|",587,2e-63,"adaptor-related protein complex 3, beta 2 subunit (predicted), isoform CRA_c [Rattus norvegicus]","gi|23396321|gb|AC105339.9|",3410,0,"Homo sapiens chromosome 15, clone RP11-752G15, complete sequence","Q9JME5",230,2e-60,"AP-3 complex subunit beta-2","SPAC23H3.06",64.7,1e-09,"COG5096","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0008089|anterograde axon cargo transport;GO:0048490|anterograde synaptic vesicle transport;GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0030123|AP-3 adaptor complex;GO:1904115|axon cytoplasm;GO:0030665|clathrin-coated vesicle membrane;GO:0005802|trans-Golgi network;",".","K12397","AP3B; AP-3 complex subunit beta"]
["ENSG00000231513",59,49,43,39.4783051772784,27,24,30,2.18796176866094,1.12958752942611,0.00038528152645862,0.0013482057478835,"up","yes","E2F6P4","processed_pseudogene","chrX:136097835-136098348:-","gi|119608886|gb|EAW88480.1|",833,8e-110,"hCG1660138 [Homo sapiens]","gi|156616391|ref|NG_006865.1|",514,0,"Homo sapiens E2F transcription factor 6 pseudogene 4 (E2F6P4) on chromosome X","Q08DY6",181,5e-55,"Transcription factor E2F6",".",".",".",".","pfam02319","E2F_TDP","E2F/DP family winged-helix DNA-binding domain. This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.","GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0006351|transcription, DNA-templated;","GO:0071339|MLL1 complex;GO:0090575|RNA polymerase II transcription factor complex;","GO:0046983|protein dimerization activity;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09390","E2F6; transcription factor E2F6"]
["ENSG00000211459",13344,13380,12071,10151.2616433419,5016,7446,8864,2.18749582551151,1.12928026379316,7.91666494722821e-40,1.8508682848744e-38,"up","yes","MT-RNR1","Mt_rRNA","chrMT:648-1601:+","gi|56507058|emb|CAH88354.1|",150,7e-10,"hypothetical protein PC101070.00.0, partial [Plasmodium chabaudi chabaudi]","gi|944326609|gb|KT956963.1|",954,0,"Homo sapiens haplogroup H2a2b mitochondrion, complete genome",".",".",".",".",".",".",".",".","pfam04791","LMBR1","LMBR1-like membrane protein. Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. A member of this family has been shown to be a lipocalin membrane receptor",".",".",".",".","."]
["ENSG00000078177",658,543,535,453.012908538191,233,335,378,2.18613233186178,1.12838073346287,9.81882171400474e-30,1.71544776467141e-28,"up","yes","N4BP2","protein_coding","chr4:40056826-40158252:+","gi|31742492|ref|NP_060647.2|",8557,0,"NEDD4-binding protein 2 isoform 1 [Homo sapiens]","gi|971460844|ref|NM_001318359.1|",9747,0,"Homo sapiens NEDD4 binding protein 2 (N4BP2), transcript variant 2, mRNA","Q86UW6",3300,0,"NEDD4-binding protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0046404|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0004519|endonuclease activity;","K15720","N4BP2; NEDD4-binding protein 2 [EC:3.-.-.-]"]
["ENSG00000250303",111,89,85,74.2122196228356,31,65,60,2.18378087985015,1.12682810377933,3.39138523365249e-06,1.55934403437929e-05,"up","yes","AP002884.1","lincRNA","chr11:112270749-112362534:+","gi|119587601|gb|EAW67197.1|",841,3e-103,"hCG2038195, partial [Homo sapiens]","gi|685156971|ref|NR_126004.1|",2749,0,"Homo sapiens uncharacterized LOC283140 (LOC283140), long non-coding RNA","Q86U02",71.6,6e-13,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000188211",87,90,87,69.2631210476201,35,57,52,2.18206277120486,1.12569260413787,3.31305814035039e-06,1.52511373296129e-05,"up","yes","NCR3LG1","protein_coding","chr11:17351726-17377341:+","gi|31873418|emb|CAD97811.1|",2453,0,"hypothetical protein [Homo sapiens]","gi|574957216|ref|NM_001202439.2|",6382,0,"Homo sapiens natural killer cell cytotoxicity receptor 3 ligand 1 (NCR3LG1), mRNA","Q68D85",824,0,"Natural cytotoxicity triggering receptor 3 ligand 1","YGR109w-b_2",77.4,4e-13,"COG2801","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.","GO:0050776|regulation of immune response;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005198|structural molecule activity;","K16349","NCR3LG1, B7H6; natural cytotoxicity triggering receptor 3 ligand 1"]
["ENSG00000260428",35,34,29,25.5641142501278,12,18,24,2.17979995209855,1.12419573988374,0.00379111503144818,0.0110591389483625,"up","yes","SCX","protein_coding","chr8:144266560-144268481:+","gi|148922889|ref|NP_001073983.1|",702,1e-88,"basic helix-loop-helix transcription factor scleraxis [Homo sapiens]","gi|767953437|ref|XM_006716616.2|",999,0,"PREDICTED: Homo sapiens scleraxis basic helix-loop-helix transcription factor (SCX), transcript variant X1, mRNA","Q7RTU7",275,4e-90,"Basic helix-loop-helix transcription factor scleraxis",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0030509|BMP signaling pathway;GO:0030154|cell differentiation;GO:0071260|cellular response to mechanical stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0002062|chondrocyte differentiation;GO:0030199|collagen fibril organization;GO:0035993|deltoid tuberosity development;GO:0048706|embryonic skeletal system development;GO:0001958|endochondral ossification;GO:0060325|face morphogenesis;GO:0003188|heart valve formation;GO:0003179|heart valve morphogenesis;GO:0001707|mesoderm formation;GO:0043066|negative regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0061036|positive regulation of cartilage development;GO:0008284|positive regulation of cell proliferation;GO:0032967|positive regulation of collagen biosynthetic process;GO:2000543|positive regulation of gastrulation;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0061035|regulation of cartilage development;GO:0061056|sclerotome development;GO:0060008|Sertoli cell differentiation;GO:0035914|skeletal muscle cell differentiation;GO:0035990|tendon cell differentiation;GO:0035989|tendon development;GO:0035992|tendon formation;GO:0001894|tissue homeostasis;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0043425|bHLH transcription factor binding;GO:0003677|DNA binding;GO:0070888|E-box binding;GO:0046982|protein heterodimerization activity;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001205|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;",".","."]
["ENSG00000130222",34,29,25,22.9555506938273,12,17,19,2.17942491493787,1.12394750113961,0.00599376476395223,0.0167571727449066,"up","yes","GADD45G","protein_coding","chr9:89605013-89606555:+","gi|5729836|ref|NP_006696.1|",753,1e-96,"growth arrest and DNA damage-inducible protein GADD45 gamma [Homo sapiens]","gi|209413759|ref|NM_006705.3|",1065,0,"Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA","O95257",294,5e-98,"Growth arrest and DNA damage-inducible protein GADD45 gamma",".",".",".",".","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:0000185|activation of MAPKKK activity;GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0043065|positive regulation of apoptotic process;GO:0046330|positive regulation of JNK cascade;GO:1900745|positive regulation of p38MAPK cascade;GO:0051726|regulation of cell cycle;GO:0006950|response to stress;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".","K04402","GADD45; growth arrest and DNA-damage-inducible protein"]
["ENSG00000156804",716,643,691,538.148175500715,322,353,443,2.17727538819749,1.12252389538091,1.73529342900046e-34,3.48286572929873e-33,"up","yes","FBXO32","protein_coding","chr8:123497889-123541206:-","gi|635050006|ref|XP_007999672.1|",2020,0,"PREDICTED: F-box only protein 32 [Chlorocebus sabaeus]","gi|335057517|ref|NM_058229.3|",6744,0,"Homo sapiens F-box protein 32 (FBXO32), transcript variant 1, mRNA","Q969P5",738,0,"F-box only protein 32",".",".",".",".","pfam06881","Elongin_A","RNA polymerase II transcription factor SIII (Elongin) subunit A. This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.","GO:0071549|cellular response to dexamethasone stimulus;GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0014894|response to denervation involved in regulation of muscle adaptation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0019005|SCF ubiquitin ligase complex;GO:0030018|Z disc;","GO:0004842|ubiquitin-protein transferase activity;","K10305","FBXO25_32; F-box protein 25/32"]
["ENSG00000109321",1007,1050,902,776.131710351212,439,558,618,2.174884431169,1.12093874118705,8.97868586378514e-46,2.38213057690079e-44,"up","yes","AREG","protein_coding","chr4:74445134-74455009:+","gi|4502199|ref|NP_001648.1|",809,8e-103,"amphiregulin preproprotein [Homo sapiens]","gi|609878452|ref|NM_001657.3|",1240,0,"Homo sapiens amphiregulin (AREG), mRNA","P15514",316,3e-104,"Amphiregulin",".",".",".",".","pfam05178","Kri1","KRI1-like family. The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus.","GO:0008283|cell proliferation;GO:0007267|cell-cell signaling;GO:0048208|COPII vesicle coating;GO:0060598|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0060750|epithelial cell proliferation involved in mammary gland duct elongation;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0007186|G-protein coupled receptor signaling pathway;GO:0014009|glial cell proliferation;GO:0060749|mammary gland alveolus development;GO:0060744|mammary gland branching involved in thelarche;GO:0045668|negative regulation of osteoblast differentiation;GO:0031175|neuron projection development;GO:0008284|positive regulation of cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051591|response to cAMP;GO:0032355|response to estradiol;GO:0051384|response to glucocorticoid;GO:0042542|response to hydrogen peroxide;GO:0043434|response to peptide hormone;","GO:0009986|cell surface;GO:0005789|endoplasmic reticulum membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507|ER to Golgi transport vesicle membrane;GO:0005615|extracellular space;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0005634|nucleus;","GO:0005125|cytokine activity;GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;","K09782","AREG; amphiregulin"]
["ENSG00000231721",87,60,70,56.675811844383,28,44,47,2.17261766114605,1.11943431032176,3.01164564663582e-05,0.000123487715204744,"up","yes","LINC-PINT","processed_transcript","chr7:130938963-131110176:-","gi|795153028|ref|XP_011795026.1|",583,4e-65,"PREDICTED: formin-like protein 18 [Colobus angolensis palliatus]","gi|551862780|tpe|HG500619.1|",3505,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000338002.1 (LINC-PINT gene), antisense","Q86U02",54.7,5e-07,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000272068",185,186,160,138.929755948395,69,94,131,2.16856817853717,1.11674280141695,7.15152264538729e-11,5.12401815691791e-10,"up","yes","AL365181.2","lincRNA","chr1:156637783-156641004:-","gi|355561739|gb|EHH18371.1|",175,1e-11,"hypothetical protein EGK_14950, partial [Macaca mulatta]","gi|551898330|tpe|HG492811.1|",3222,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000470701.1 (RP11-284F21.9 gene), lincRNA","Q8WTZ3",50.1,1e-08,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000197841",161,175,174,133.818790111402,56,102,127,2.16794613093777,1.11632890909286,1.98000967492233e-09,1.24886941170379e-08,"up","yes","ZNF181","protein_coding","chr19:34734155-34745378:+","gi|224586802|ref|NP_001025168.2|",3058,0,"zinc finger protein 181 isoform 1 [Homo sapiens]","gi|21206235|gb|AC020910.7|",4772,0,"Homo sapiens chromosome 19 clone CTD-2553L13, complete sequence","Q2M3W8",1182,0,"Zinc finger protein 181",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000066230",42,37,37,30.5326266082757,21,19,23,2.16564393227585,1.11479605948932,0.00182775534855618,0.00570079967059371,"up","yes","SLC9A3","protein_coding","chr5:470458-524332:-","gi|194239733|ref|NP_004165.2|",3586,0,"sodium/hydrogen exchanger 3 isoform 1 [Homo sapiens]","gi|28827853|gb|AC106772.3|",2930,0,"Homo sapiens chromosome 5 clone RP11-310P5, complete sequence","P48764",1385,0,"Sodium/hydrogen exchanger 3","SPAC15A10.06",152,3e-37,"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0006811|ion transport;GO:0071805|potassium ion transmembrane transport;GO:0051453|regulation of intracellular pH;GO:0098719|sodium ion import across plasma membrane;","GO:0016324|apical plasma membrane;GO:0005903|brush border;GO:0031526|brush border membrane;GO:0009986|cell surface;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0030165|PDZ domain binding;GO:0015386|potassium:proton antiporter activity;GO:0015385|sodium:proton antiporter activity;","K12040","SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3"]
["ENSG00000145217",155,118,131,105.738586908653,57,69,97,2.16495447755973,1.11433668976064,1.32397949574277e-08,7.74080524822264e-08,"up","yes","SLC26A1","protein_coding","chr4:979073-993440:-","gi|20336272|ref|NP_071325.2|",3126,0,"sulfate anion transporter 1 isoform a [Homo sapiens]","gi|515869213|ref|NM_213613.3|",3660,0,"Homo sapiens solute carrier family 26 member 1 (SLC26A1), transcript variant 3, mRNA","Q9H2B4",1208,0,"Sulfate anion transporter 1","Cgl1025",145,2e-35,"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0050428|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0015701|bicarbonate transport;GO:1902476|chloride transmembrane transport;GO:0006821|chloride transport;GO:0006811|ion transport;GO:0019532|oxalate transport;GO:0051453|regulation of intracellular pH;GO:0042391|regulation of membrane potential;GO:0008272|sulfate transport;","GO:0016323|basolateral plasma membrane;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015301|anion:anion antiporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0005254|chloride channel activity;GO:0015108|chloride transmembrane transporter activity;GO:0019531|oxalate transmembrane transporter activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;","K14700","SLC26A1, SAT1; solute carrier family 26 (sulfate anion transporter), member 1"]
["ENSG00000149289",2028,1877,1790,1495.42045909393,873,1022,1229,2.16371936747865,1.11351339500522,1.36724849092173e-89,7.89565535715521e-88,"up","yes","ZC3H12C","protein_coding","chr11:110093361-110171841:+","gi|530398466|ref|XP_005271772.1|",4291,0,"PREDICTED: probable ribonuclease ZC3H12C isoform X1 [Homo sapiens]","gi|30314564|dbj|AB096241.1|",9536,0,"Homo sapiens LOH11CR1B gene, loss of heterozygosity, 11, chromosomal region 1 gene B product","Q9C0D7",1656,0,"Probable ribonuclease ZC3H12C",".",".",".",".","pfam11977","RNase_Zc3h12a","Zc3h12a-like Ribonuclease NYN domain. This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.",".",".","GO:0004519|endonuclease activity;GO:0046872|metal ion binding;","K18668","ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]"]
["ENSG00000179148",83,72,86,63.2873803027319,33,40,61,2.16306123488884,1.11307450765772,1.05100383531942e-05,4.58118914703753e-05,"up","yes","ALOXE3","protein_coding","chr17:8095900-8119047:-","gi|119610499|gb|EAW90093.1|",4391,0,"arachidonate lipoxygenase 3, isoform CRA_a [Homo sapiens]","gi|10799675|emb|AJ269499.1|",3344,0,"Homo sapiens mRNA for lipoxygenase-3 (ALOXE3 gene)","Q9BYJ1",1482,0,"Hydroperoxide isomerase ALOXE3",".",".",".",".","pfam00305","Lipoxygenase","Lipoxygenase.","GO:0019369|arachidonic acid metabolic process;GO:0046513|ceramide biosynthetic process;GO:0061436|establishment of skin barrier;GO:0045444|fat cell differentiation;GO:0051122|hepoxilin biosynthetic process;GO:0043651|linoleic acid metabolic process;GO:0019372|lipoxygenase pathway;GO:0035357|peroxisome proliferator activated receptor signaling pathway;GO:0019233|sensory perception of pain;GO:0006665|sphingolipid metabolic process;","GO:0005829|cytosol;","GO:0051120|hepoxilin A3 synthase activity;GO:0005506|iron ion binding;GO:0016829|lyase activity;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;","K18684","ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase [EC:4.2.1.152 5.4.4.7]"]
["ENSG00000099957",35,33,36,27.442196923173,18,17,22,2.15981732898639,1.11090929863421,0.00312910658988808,0.00930530495000946,"up","yes","P2RX6","protein_coding","chr22:21009808-21028830:+","gi|157419148|ref|NP_005437.2|",2212,0,"P2X purinoceptor 6 isoform 1 [Homo sapiens]","gi|426393638|ref|XM_004063075.1|",3537,0,"PREDICTED: Gorilla gorilla gorilla purinergic receptor P2X, ligand-gated ion channel, 6, transcript variant 1 (P2RX6), mRNA","O15547",856,0,"P2X purinoceptor 6",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0007596|blood coagulation;GO:0006936|muscle contraction;GO:0051260|protein homooligomerization;GO:0033198|response to ATP;GO:0007165|signal transduction;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005639|integral component of nuclear inner membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0098794|postsynapse;","GO:0005524|ATP binding;GO:0015267|channel activity;GO:0004931|extracellular ATP-gated cation channel activity;GO:0042802|identical protein binding;GO:0001614|purinergic nucleotide receptor activity;GO:0004888|transmembrane signaling receptor activity;","K05221","P2RX6, P2RXL1; P2X purinoceptor 6"]
["ENSG00000131981",3543,3507,3370,2741.79530697795,1587,1796,2377,2.15584929425939,1.10825632928525,2.8309109057345e-118,2.38439343012258e-116,"up","yes","LGALS3","protein_coding","chr14:55124110-55145413:+","gi|308387726|pdb|2XG3|A",718,9e-89,"Chain A, Human Galectin-3 In Complex With A Benzamido-N- Acetyllactoseamine Inhibitor","gi|294345472|ref|NR_003225.2|",1734,0,"Homo sapiens lectin, galactoside-binding, soluble, 3 (LGALS3), transcript variant 2, non-coding RNA","P17931",284,5e-90,"Galectin-3",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0048245|eosinophil chemotaxis;GO:0030855|epithelial cell differentiation;GO:0045087|innate immune response;GO:0031640|killing of cells of other organism;GO:0048246|macrophage chemotaxis;GO:0002548|monocyte chemotaxis;GO:0071674|mononuclear cell migration;GO:0006397|mRNA processing;GO:0045806|negative regulation of endocytosis;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2000521|negative regulation of immunological synapse formation;GO:2001189|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0043312|neutrophil degranulation;GO:0050918|positive chemotaxis;GO:0090280|positive regulation of calcium ion import;GO:0071677|positive regulation of mononuclear cell migration;GO:1902041|regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045637|regulation of myeloid cell differentiation;GO:0070232|regulation of T cell apoptotic process;GO:0042129|regulation of T cell proliferation;GO:0008380|RNA splicing;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0001772|immunological synapse;GO:0016020|membrane;GO:0005743|mitochondrial inner membrane;GO:0005634|nucleus;GO:0044216|other organism cell;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;GO:0005681|spliceosomal complex;","GO:0030246|carbohydrate binding;GO:0042056|chemoattractant activity;GO:0019863|IgE binding;GO:0043236|laminin binding;GO:0070492|oligosaccharide binding;GO:0003723|RNA binding;","K06831","LGALS3; galectin-3"]
["ENSG00000183044",23,27,24,19.5080997869169,12,11,18,2.15577483979749,1.10820650347501,0.0129666391901103,0.0336382698989706,"up","yes","ABAT","protein_coding","chr16:8674565-8784575:+","gi|221039754|dbj|BAH11640.1|",2765,0,"unnamed protein product [Homo sapiens]","gi|188536078|ref|NM_000663.4|",5586,0,"Homo sapiens 4-aminobutyrate aminotransferase (ABAT), transcript variant 2, mRNA","P80404",1046,0,"4-aminobutyrate aminotransferase, mitochondrial","SPAC19D5.07",405,4e-125,"COG0160","pfam00202","Aminotran_3","Aminotransferase class-III.","GO:0007568|aging;GO:0048148|behavioral response to cocaine;GO:0021549|cerebellum development;GO:0007620|copulation;GO:0035640|exploration behavior;GO:0009449|gamma-aminobutyric acid biosynthetic process;GO:0009450|gamma-aminobutyric acid catabolic process;GO:0007626|locomotory behavior;GO:0045776|negative regulation of blood pressure;GO:0033602|negative regulation of dopamine secretion;GO:0014053|negative regulation of gamma-aminobutyric acid secretion;GO:0090331|negative regulation of platelet aggregation;GO:0042135|neurotransmitter catabolic process;GO:1904450|positive regulation of aspartate secretion;GO:0045964|positive regulation of dopamine metabolic process;GO:0031652|positive regulation of heat generation;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:0032024|positive regulation of insulin secretion;GO:1902722|positive regulation of prolactin secretion;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0045471|response to ethanol;GO:0001666|response to hypoxia;GO:0010039|response to iron ion;GO:0035094|response to nicotine;","GO:0032144|4-aminobutyrate transaminase complex;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0043005|neuron projection;","GO:0047298|(S)-3-amino-2-methylpropionate transaminase activity;GO:0003867|4-aminobutyrate transaminase activity;GO:0034386|4-aminobutyrate:2-oxoglutarate transaminase activity;GO:0051536|iron-sulfur cluster binding;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0030170|pyridoxal phosphate binding;GO:0032145|succinate-semialdehyde dehydrogenase binding;","K13524","ABAT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]"]
["ENSG00000104549",1058,978,955,786.376232033998,440,543,672,2.1527606557363,1.10618792936261,9.64074863030634e-53,2.93297728046291e-51,"up","yes","SQLE","protein_coding","chr8:124998497-125022283:+","gi|62865635|ref|NP_003120.2|",2588,0,"squalene monooxygenase [Homo sapiens]","gi|62865634|ref|NM_003129.3|",2961,0,"Homo sapiens squalene epoxidase (SQLE), mRNA","Q14534",1001,0,"Squalene monooxygenase","SPBC713.12",318,1e-96,"COG0654","pfam08491","SE","Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.  SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.","GO:0006725|cellular aromatic compound metabolic process;GO:0006695|cholesterol biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0045540|regulation of cholesterol biosynthetic process;GO:0010033|response to organic substance;GO:0016126|sterol biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031090|organelle membrane;","GO:0050660|flavin adenine dinucleotide binding;GO:0004506|squalene monooxygenase activity;","K00511","SQLE, ERG1; squalene monooxygenase [EC:1.14.13.132]"]
["ENSG00000163874",438,393,375,316.908979333041,179,219,269,2.15087406372159,1.10492305569392,3.94694236912107e-23,5.38011479968956e-22,"up","yes","ZC3H12A","protein_coding","chr1:37474552-37484379:+","gi|156151383|ref|NP_079355.2|",2582,0,"ribonuclease ZC3H12A [Homo sapiens]","gi|156151382|ref|NM_025079.2|",1731,0,"Homo sapiens zinc finger CCCH-type containing 12A (ZC3H12A), mRNA","Q5D1E8",999,0,"Endoribonuclease ZC3H12A",".",".",".",".","pfam11977","RNase_Zc3h12a","Zc3h12a-like Ribonuclease NYN domain. This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.","GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0001525|angiogenesis;GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:1990869|cellular response to chemokine;GO:0006974|cellular response to DNA damage stimulus;GO:0042149|cellular response to glucose starvation;GO:0071347|cellular response to interleukin-1;GO:1904637|cellular response to ionomycin;GO:0071222|cellular response to lipopolysaccharide;GO:0034599|cellular response to oxidative stress;GO:1903936|cellular response to sodium arsenite;GO:0071356|cellular response to tumor necrosis factor;GO:0098586|cellular response to virus;GO:0051607|defense response to virus;GO:0002757|immune response-activating signal transduction;GO:0006954|inflammatory response;GO:0044828|negative regulation by host of viral genome replication;GO:0055118|negative regulation of cardiac muscle contraction;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:0010629|negative regulation of gene expression;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:1902714|negative regulation of interferon-gamma secretion;GO:0050713|negative regulation of interleukin-1 beta secretion;GO:0032715|negative regulation of interleukin-6 production;GO:1900165|negative regulation of interleukin-6 secretion;GO:0043031|negative regulation of macrophage activation;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:1903799|negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0001933|negative regulation of protein phosphorylation;GO:2000320|negative regulation of T-helper 17 cell differentiation;GO:0032720|negative regulation of tumor necrosis factor production;GO:1904468|negative regulation of tumor necrosis factor secretion;GO:0007399|nervous system development;GO:0000294|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;GO:0045766|positive regulation of angiogenesis;GO:0010508|positive regulation of autophagy;GO:0010942|positive regulation of cell death;GO:0002230|positive regulation of defense response to virus by host;GO:0010595|positive regulation of endothelial cell migration;GO:1900119|positive regulation of execution phase of apoptosis;GO:0045600|positive regulation of fat cell differentiation;GO:0010628|positive regulation of gene expression;GO:0010884|positive regulation of lipid storage;GO:2000627|positive regulation of miRNA catabolic process;GO:0061014|positive regulation of mRNA catabolic process;GO:1900745|positive regulation of p38MAPK cascade;GO:1903003|positive regulation of protein deubiquitination;GO:0042307|positive regulation of protein import into nucleus;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051259|protein oligomerization;GO:0016579|protein deubiquitination;GO:0010468|regulation of gene expression;GO:0090501|RNA phosphodiester bond hydrolysis;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0050852|T cell receptor signaling pathway;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0005856|cytoskeleton;GO:0042406|extrinsic component of endoplasmic reticulum membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000932|cytoplasmic mRNA processing body;GO:0032991|macromolecular complex;GO:0005791|rough endoplasmic reticulum;GO:0030867|rough endoplasmic reticulum membrane;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0004521|endoribonuclease activity;GO:0004532|exoribonuclease activity;GO:0046872|metal ion binding;GO:0035198|miRNA binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0003730|mRNA 3'-UTR binding;GO:0003729|mRNA binding;GO:0004540|ribonuclease activity;GO:0043022|ribosome binding;GO:0003723|RNA binding;GO:0035613|RNA stem-loop binding;","K18668","ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]"]
["ENSG00000270210",28,26,18,18.8064706073608,10,12,18,2.15003194787915,1.10435809735166,0.0152451912974177,0.0388388917903305,"up","yes","AC104695.2","lincRNA","chr2:28425945-28426719:+",".",".",".",".","gi|551844888|tpe|HG493794.1|",775,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000470097.1 (RP11-373D23.3 gene), lincRNA",".",".",".",".",".",".",".",".","pfam11888","DUF3408","Protein of unknown function (DUF3408). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 128 to 160 amino acids in length.",".",".",".",".","."]
["ENSG00000225345",55,37,51,37.5756981951849,20,24,36,2.14344060561794,1.09992844086954,0.000811268006826286,0.0026964910073523,"up","yes","SNX18P3","transcribed_unprocessed_pseudogene","chr9:38566260-38568211:-","gi|686770477|ref|XP_009234256.1|",452,2e-47,"PREDICTED: uncharacterized protein LOC100451088 [Pongo abelii]","gi|16972948|emb|AL390726.19|",1750,0,"Human DNA sequence from clone RP11-392E22 on chromosome 9, complete sequence","Q91ZR2",103,5e-35,"Sorting nexin-18",".",".",".",".","pfam10456","BAR_3_WASP_bdg","WASP-binding domain of Sorting nexin protein. The C-terminal region of the Sorting nexin group of proteins appears to carry a BAR-like (Bin/amphiphysin/Rvs) domain. This domain is very diverse and the similarities with other BAR domains are few. In the Sorting nexins it is associated with family PX, pfam00787.13, and in combination with PX appears to be necessary to bind WASP along with p85 to form a multimeric signalling complex.","GO:0036089|cleavage furrow formation;GO:0006897|endocytosis;GO:0016197|endosomal transport;GO:0000281|mitotic cytokinesis;GO:0043547|positive regulation of GTPase activity;GO:0015031|protein transport;","GO:0031410|cytoplasmic vesicle;GO:0030659|cytoplasmic vesicle membrane;GO:0010008|endosome membrane;GO:0070062|extracellular exosome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0030426|growth cone;GO:0043025|neuronal cell body;","GO:0035091|phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;",".","."]
["ENSG00000136603",503,522,466,393.240078512796,238,260,328,2.14323944312338,1.0997930371864,5.20725747046133e-26,7.99662277788679e-25,"up","yes","SKIL","protein_coding","chr3:170357678-170396835:+","gi|223029418|ref|NP_005405.2|",3259,0,"ski-like protein isoform 1 [Homo sapiens]","gi|351722050|ref|NM_001248008.1|",7182,0,"Homo sapiens SKI-like proto-oncogene (SKIL), transcript variant 4, mRNA","P12757",1259,0,"Ski-like protein",".",".",".",".","pfam02437","Ski_Sno","SKI/SNO/DAC family. This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.","GO:0001825|blastocyst formation;GO:0007050|cell cycle arrest;GO:0070306|lens fiber cell differentiation;GO:0002260|lymphocyte homeostasis;GO:0030514|negative regulation of BMP signaling pathway;GO:0045596|negative regulation of cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0048666|neuron development;GO:0050772|positive regulation of axonogenesis;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902231|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0070208|protein heterotrimerization;GO:0070207|protein homotrimerization;GO:0046677|response to antibiotic;GO:0034097|response to cytokine;GO:0070848|response to growth factor;GO:0007519|skeletal muscle tissue development;GO:0007283|spermatogenesis;GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0019904|protein domain specific binding;GO:0044877|macromolecular complex binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0046332|SMAD binding;GO:0003714|transcription corepressor activity;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K18499","SKIL; Ski-like protein"]
["ENSG00000258839",76,50,50,46.1806060231579,28,38,30,2.14210223016532,1.09902733323156,0.00032209953770793,0.00114245235073751,"up","yes","MC1R","protein_coding","chr16:89912119-89920977:+","gi|30582781|gb|AAP35617.1|",1497,0,"tubulin, beta, 4 [Homo sapiens]","gi|164696966|dbj|AK311630.1|",2515,0,"Homo sapiens cDNA, FLJ18672","Q01726",479,3e-157,"Melanocyte-stimulating hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007187|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0032720|negative regulation of tumor necrosis factor production;GO:0043473|pigmentation;GO:0010739|positive regulation of protein kinase A signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0090037|positive regulation of protein kinase C signaling;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009650|UV protection;GO:0070914|UV-damage excision repair;","GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0008528|G-protein coupled peptide receptor activity;GO:0004977|melanocortin receptor activity;GO:0004980|melanocyte-stimulating hormone receptor activity;GO:0031625|ubiquitin protein ligase binding;","K04199","MC1R; melanocortin 1 receptor"]
["ENSG00000186889",48,35,32,30.0806029576514,18,16,30,2.14203860065456,1.09898447844071,0.00271352411641381,0.00817916129979522,"up","yes","TMEM17","protein_coding","chr2:62500221-62511894:-","gi|767914157|ref|XP_011530995.1|",493,2e-54,"PREDICTED: transmembrane protein 17 isoform X2 [Homo sapiens]","gi|21750377|dbj|AK091902.1|",2439,0,"Homo sapiens cDNA FLJ34583 fis, clone KIDNE2008666","Q86X19",195,7e-56,"Transmembrane protein 17",".",".",".",".","pfam09799","Transmemb_17","Predicted membrane protein. This is a 100 amino acid region of a family of proteins conserved from nematodes to humans. It is predicted to be a transmembrane region but its function is not known.","GO:0060271|cilium morphogenesis;GO:0007224|smoothened signaling pathway;","GO:0060170|ciliary membrane;GO:0035869|ciliary transition zone;GO:0016021|integral component of membrane;GO:0036038|TCTN-B9D complex;",".","K19384","TMEM17; transmembrane protein 17"]
["ENSG00000227398",43,49,49,37.2568207250361,21,23,35,2.14179859395069,1.09882282127864,0.000725950932025433,0.00242997107891531,"up","yes","KIF9-AS1","antisense","chr3:47164497-47246601:+","gi|767924021|ref|XP_011532309.1|",329,7e-29,"PREDICTED: kinesin-like protein KIF9 isoform X8 [Homo sapiens]","gi|551849630|tpe|HG495644.1|",4898,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000344527.3 (RP11-447D11.2 gene), antisense","Q9HAQ2",132,8e-30,"Kinesin-like protein KIF9",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0022617|extracellular matrix disassembly;GO:0007018|microtubule-based movement;GO:1903008|organelle disassembly;GO:0071801|regulation of podosome assembly;","GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0002102|podosome;GO:0031982|vesicle;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0046983|protein dimerization activity;","K10397","KIF6_9; kinesin family member 6/9"]
["ENSG00000260916",430,367,377,309.27560038676,178,227,245,2.14097727764825,1.09826948437446,2.76193939798515e-21,3.48412603717054e-20,"up","yes","CCPG1","protein_coding","chr15:55340032-55408510:-","gi|75677574|ref|NP_065790.2|",3555,0,"cell cycle progression protein 1 isoform 1 [Homo sapiens]","gi|325053638|ref|NM_020739.3|",6822,0,"Homo sapiens cell cycle progression 1 (CCPG1), transcript variant 2, mRNA","Q9ULG6",1373,0,"Cell cycle progression protein 1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007049|cell cycle;GO:0045787|positive regulation of cell cycle;GO:0008284|positive regulation of cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:2001106|regulation of Rho guanyl-nucleotide exchange factor activity;","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000223745",726,636,606,518.329529252548,311,374,401,2.14089083075998,1.09821123106358,5.27794671528513e-32,1.00006424024833e-30,"up","yes","CCDC18-AS1","processed_transcript","chr1:93262186-93346025:-","gi|2072961|gb|AAC51269.1|",257,3e-38,"putative p150 [Homo sapiens]","gi|300796766|ref|NR_034089.1|",2973,0,"Homo sapiens CCDC18 antisense RNA 1 (CCDC18-AS1), long non-coding RNA","O00370",100,7e-39,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["ENSG00000226416",45,34,29,28.2619122677459,17,16,27,2.14005294277769,1.09764648790588,0.00344830038661863,0.0101620806504355,"up","yes","MRPL23-AS1","antisense","chr11:1983237-1989920:-","gi|119622880|gb|EAX02475.1|",695,1e-84,"hCG2045710 [Homo sapiens]","gi|213417947|ref|NR_024471.1|",1876,0,"Homo sapiens MRPL23 antisense RNA 1 (MRPL23-AS1), long non-coding RNA",".",".",".",".",".",".",".",".","pfam02161","Prog_receptor","Progesterone receptor.",".",".",".",".","."]
["ENSG00000172602",41,41,36,31.0197475639083,14,26,26,2.13992385709519,1.09755946347432,0.00199307323552193,0.00617707378403968,"up","yes","RND1","protein_coding","chr12:48857145-48865898:-","gi|119578422|gb|EAW58018.1|",489,7e-55,"hCG1998117 [Homo sapiens]","gi|27452893|gb|AC117498.6|",2136,0,"Homo sapiens 12 BAC RP11-579D7 (Roswell Park Cancer Institute Human BAC Library) complete sequence","Q92730",164,8e-45,"Rho-related GTP-binding protein Rho6",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007015|actin filament organization;GO:0007162|negative regulation of cell adhesion;GO:0016322|neuron remodeling;GO:0007264|small GTPase mediated signal transduction;","GO:0015629|actin cytoskeleton;GO:0005912|adherens junction;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005102|receptor binding;","K07531","RND1; Rho family GTPase 1"]
["ENSG00000101665",623,652,582,490.269144308128,294,344,391,2.13910920968107,1.0970101394657,1.28183309676947e-30,2.31932427490522e-29,"up","yes","SMAD7","protein_coding","chr18:48919853-48952052:-","gi|149027134|gb|EDL82858.1|",1696,0,"MAD homolog 7 (Drosophila), isoform CRA_a [Rattus norvegicus]","gi|299890803|ref|NM_005904.3|",3087,0,"Homo sapiens SMAD family member 7 (SMAD7), transcript variant 1, mRNA","O15105",620,0,"Mothers against decapentaplegic homolog 7",".",".",".",".","pfam03166","MH2","MH2 domain. This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.","GO:0034333|adherens junction assembly;GO:0048844|artery morphogenesis;GO:0030509|BMP signaling pathway;GO:0034629|cellular protein complex localization;GO:1990830|cellular response to leukemia inhibitory factor;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0030514|negative regulation of BMP signaling pathway;GO:0030336|negative regulation of cell migration;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0010801|negative regulation of peptidyl-threonine phosphorylation;GO:0031397|negative regulation of protein ubiquitination;GO:0002725|negative regulation of T cell cytokine production;GO:2000320|negative regulation of T-helper 17 cell differentiation;GO:2000317|negative regulation of T-helper 17 type immune response;GO:0010944|negative regulation of transcription by competitive promoter binding;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0051444|negative regulation of ubiquitin-protein transferase activity;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0022409|positive regulation of cell-cell adhesion;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031398|positive regulation of protein ubiquitination;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016579|protein deubiquitination;GO:0050821|protein stabilization;GO:0032925|regulation of activin receptor signaling pathway;GO:0055117|regulation of cardiac muscle contraction;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0060373|regulation of ventricular cardiac muscle cell membrane depolarization;GO:0034616|response to laminar fluid shear stress;GO:0006351|transcription, DNA-templated;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0001657|ureteric bud development;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060412|ventricular septum morphogenesis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0005667|transcription factor complex;","GO:0048185|activin binding;GO:0008013|beta-catenin binding;GO:0005518|collagen binding;GO:0070411|I-SMAD binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;GO:0030617|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity;GO:0034713|type I transforming growth factor beta receptor binding;GO:0031625|ubiquitin protein ligase binding;",".","."]
["ENSG00000185010",207,194,148,143.970282221771,75,104,127,2.13881011326131,1.09680840357979,1.49112315857336e-10,1.03942115947102e-09,"up","yes","F8","protein_coding","chrX:154835788-155026940:-","gi|4503647|ref|NP_000123.1|",12413,0,"coagulation factor VIII isoform a preproprotein [Homo sapiens]","gi|192448441|ref|NM_000132.3|",9026,0,"Homo sapiens coagulation factor VIII (F8), transcript variant 1, mRNA","P00451",4786,0,"Coagulation factor VIII",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0006953|acute-phase response;GO:0007596|blood coagulation;GO:0007597|blood coagulation, intrinsic pathway;GO:0048208|COPII vesicle coating;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0030168|platelet activation;GO:0002576|platelet degranulation;","GO:0030134|ER to Golgi transport vesicle;GO:0005788|endoplasmic reticulum lumen;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0000139|Golgi membrane;GO:0005886|plasma membrane;GO:0031093|platelet alpha granule lumen;","GO:0005507|copper ion binding;GO:0016491|oxidoreductase activity;","K03899","F8; coagulation factor VIII"]
["ENSG00000114423",409,336,383,297.44047660655,171,209,247,2.138655329802,1.09670399346486,6.54269633693748e-20,7.7946588602131e-19,"up","yes","CBLB","protein_coding","chr3:105655461-105869552:-","gi|675781136|ref|XP_008976993.1|",4537,0,"PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X1 [Pan paniscus]","gi|931568750|ref|XM_003825051.3|",6520,0,"PREDICTED: Pan paniscus Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB), transcript variant X2, mRNA","Q13191",1739,0,"E3 ubiquitin-protein ligase CBL-B",".",".",".",".","pfam02262","Cbl_N","CBL proto-oncogene N-terminal domain 1. Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.","GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0006607|NLS-bearing protein import into nucleus;GO:0006508|proteolysis;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0045121|membrane raft;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0001784|phosphotyrosine binding;GO:0030971|receptor tyrosine kinase binding;GO:0017124|SH3 domain binding;GO:0061630|ubiquitin protein ligase activity;GO:0008270|zinc ion binding;",".","."]
["ENSG00000061455",25,26,27,20.5791410972974,12,10,22,2.13768651403826,1.09605030123312,0.0127161589662614,0.0330551582400607,"up","yes","PRDM6","protein_coding","chr5:123089121-123194266:+","gi|210031233|ref|NP_001129711.1|",2327,0,"putative histone-lysine N-methyltransferase PRDM6 [Homo sapiens]","gi|767936765|ref|XM_005272128.3|",8871,0,"PREDICTED: Homo sapiens PR domain containing 6 (PRDM6), transcript variant X1, mRNA","Q9NQX0",894,0,"Putative histone-lysine N-methyltransferase PRDM6",".",".",".",".","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0051151|negative regulation of smooth muscle cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0022008|neurogenesis;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0018024|histone-lysine N-methyltransferase activity;GO:0046872|metal ion binding;GO:0003676|nucleic acid binding;GO:0042803|protein homodimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000183092",96,61,75,61.2217338795215,44,44,38,2.13589812996614,1.09484284042558,6.96237299932943e-05,0.000270637344641407,"up","yes","BEGAIN","protein_coding","chr14:100537147-100587413:-","gi|7959151|dbj|BAA95970.1|",2609,0,"KIAA1446 protein [Homo sapiens]","gi|7959150|dbj|AB040879.1|",5766,0,"Homo sapiens mRNA for KIAA1446 protein, partial cds","Q9BUH8",997,0,"Brain-enriched guanylate kinase-associated protein",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".","GO:0005737|cytoplasm;GO:0016020|membrane;",".",".","."]
["ENSG00000123454",54,30,25,28.3725158716249,16,21,23,2.13589461405231,1.09484046559527,0.00504322468635317,0.0143281363603447,"up","yes","DBH","protein_coding","chr9:133635348-133659344:+","gi|116534900|ref|NP_000778.3|",3227,0,"dopamine beta-hydroxylase precursor [Homo sapiens]","gi|694937946|ref|XM_520341.5|",3330,0,"PREDICTED: Pan troglodytes dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH), transcript variant X1, mRNA","P09172",1247,0,"Dopamine beta-hydroxylase",".",".",".",".","pfam03712","Cu2_monoox_C","Copper type II ascorbate-dependent monooxygenase, C-terminal domain. The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.","GO:0048149|behavioral response to ethanol;GO:0001974|blood vessel remodeling;GO:0042423|catecholamine biosynthetic process;GO:0007268|synaptic transmission;GO:0001816|cytokine production;GO:0042420|dopamine catabolic process;GO:0042596|fear response;GO:0042593|glucose homeostasis;GO:0042309|homoiothermy;GO:0002443|leukocyte mediated immunity;GO:0050900|leukocyte migration;GO:0007626|locomotory behavior;GO:0042711|maternal behavior;GO:0007613|memory;GO:0042421|norepinephrine biosynthetic process;GO:0006589|octopamine biosynthetic process;GO:0045907|positive regulation of vasoconstriction;GO:0042127|regulation of cell proliferation;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:0001975|response to amphetamine;GO:0048265|response to pain;GO:0008542|visual learning;","GO:0034466|chromaffin granule lumen;GO:0042584|chromaffin granule membrane;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005815|microtubule organizing center;GO:0034774|secretory granule lumen;GO:0030667|secretory granule membrane;GO:0030658|transport vesicle membrane;","GO:0003824|catalytic activity;GO:0005507|copper ion binding;GO:0004500|dopamine beta-monooxygenase activity;GO:0031418|L-ascorbic acid binding;","K00503","DBH; dopamine beta-monooxygenase [EC:1.14.17.1]"]
["ENSG00000139194",88,68,73,60.2805059412307,28,59,40,2.13362663848649,1.09330774226828,7.51886840103035e-05,0.000291329718198219,"up","yes","RBP5","protein_coding","chr12:7123684-7128942:-","gi|13899352|ref|NP_113679.1|",726,4e-93,"retinol-binding protein 5 [Homo sapiens]","gi|767972434|ref|XM_011520864.1|",1012,0,"PREDICTED: Homo sapiens retinol binding protein 5, cellular (RBP5), transcript variant X1, mRNA","P82980",284,1e-94,"Retinol-binding protein 5",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;","GO:0016918|retinal binding;GO:0005501|retinoid binding;GO:0019841|retinol binding;",".","."]
["ENSG00000143013",3697,3681,3364,2834.24782098403,1580,1932,2511,2.12957284440491,1.09056407971887,5.17196533849554e-128,4.81917234052666e-126,"up","yes","LMO4","protein_coding","chr1:87328468-87348923:+","gi|351705454|gb|EHB08373.1|",894,1e-106,"LIM domain transcription factor LMO4 [Heterocephalus glaber]","gi|197382802|ref|NM_006769.3|",5405,0,"Homo sapiens LIM domain only 4 (LMO4), mRNA","P61969",343,6e-107,"LIM domain transcription factor LMO4",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0031333|negative regulation of protein complex assembly;GO:0001843|neural tube closure;GO:0033674|positive regulation of kinase activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0050865|regulation of cell activation;GO:0042659|regulation of cell fate specification;GO:0030334|regulation of cell migration;GO:0021527|spinal cord association neuron differentiation;GO:0021522|spinal cord motor neuron differentiation;GO:0048538|thymus development;GO:0006366|transcription from RNA polymerase II promoter;GO:0021514|ventral spinal cord interneuron differentiation;GO:0003281|ventricular septum development;","GO:0031252|cell leading edge;GO:0005667|transcription factor complex;","GO:0001158|enhancer sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0008134|transcription factor binding;",".","."]
["ENSG00000106070",5473,5028,4821,4044.52634150011,2353,2734,3491,2.12461695204486,1.08720276068636,2.0564931724441e-179,3.02791147405357e-177,"up","yes","GRB10","protein_coding","chr7:50590063-50793462:-","gi|40788909|dbj|BAA13198.2|",3150,0,"KIAA0207 [Homo sapiens]","gi|767945307|ref|XM_011515312.1|",5431,0,"PREDICTED: Homo sapiens growth factor receptor-bound protein 10 (GRB10), transcript variant X12, mRNA","Q13322",1162,0,"Growth factor receptor-bound protein 10",".",".",".",".","pfam08947","BPS","BPS (Between PH and SH2). The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.","GO:0007411|axon guidance;GO:0008286|insulin receptor signaling pathway;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0046325|negative regulation of glucose import;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0042326|negative regulation of phosphorylation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0042327|positive regulation of phosphorylation;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032868|response to insulin;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0042802|identical protein binding;GO:0005158|insulin receptor binding;GO:0005070|SH3/SH2 adaptor activity;",".","."]
["ENSG00000214562",71,57,63,50.4377844075991,31,31,45,2.12264153369941,1.08586075314633,9.64828788763643e-05,0.0003691651989223,"up","yes","NUTM2D","protein_coding","chr10:87357668-87370695:+","gi|24899204|dbj|BAC23116.1|",2368,0,"KIAA2020 protein [Homo sapiens]","gi|449784908|ref|NR_075100.1|",5543,0,"Homo sapiens NUT family member 2D (NUTM2D), non-coding RNA",".",".",".",".",".",".",".",".","pfam12881","NUT_N","NUT protein N terminus. This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation.",".",".",".",".","."]
["ENSG00000187650",74,76,71,58.2369242752651,27,39,60,2.12148998385348,1.08507786727865,3.74126575348944e-05,0.000151250332955993,"up","yes","VMAC","protein_coding","chr19:5904858-5910853:+","gi|119589535|gb|EAW69129.1|",520,4e-59,"vimentin-type IF-associated coiled-coil protein, isoform CRA_a [Homo sapiens]","gi|34529884|dbj|AK124162.1|",2163,0,"Homo sapiens cDNA FLJ42168 fis, clone THYMU2025707","Q2NL98",186,5e-53,"Vimentin-type intermediate filament-associated coiled-coil protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSG00000138439",387,372,352,293.723761793334,178,188,257,2.12106699410717,1.08479018925121,3.59608382160048e-20,4.32696598571617e-19,"up","yes","FAM117B","protein_coding","chr2:202635188-202769757:+","gi|254910983|ref|NP_775782.2|",1739,0,"protein FAM117B [Homo sapiens]","gi|254910982|ref|NM_173511.3|",5763,0,"Homo sapiens family with sequence similarity 117 member B (FAM117B), mRNA",".",".",".",".",".",".",".",".","pfam15388","FAM117","Protein Family FAM117. This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.",".",".",".",".","."]
["ENSG00000198814",158,156,137,118.983055959365,61,86,108,2.1168130666582,1.08189387222092,2.65892686821682e-09,1.65436714303761e-08,"up","yes","GK","protein_coding","chrX:30653359-30731456:+","gi|326381123|ref|NP_001191948.1|",2907,0,"glycerol kinase isoform d [Homo sapiens]","gi|326381122|ref|NM_001205019.1|",4573,0,"Homo sapiens glycerol kinase (GK), transcript variant 4, mRNA","P32189",1121,0,"Glycerol kinase","Rv3696c",481,3e-153,"COG0554","pfam00370","FGGY_N","FGGY family of carbohydrate kinases, N-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.","GO:0019563|glycerol catabolic process;GO:0006071|glycerol metabolic process;GO:0046167|glycerol-3-phosphate biosynthetic process;GO:0019432|triglyceride biosynthetic process;GO:0006641|triglyceride metabolic process;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0004370|glycerol kinase activity;","K00864","glpK, GK; glycerol kinase [EC:2.7.1.30]"]
["ENSG00000251136",213,184,175,150.938133273368,86,102,134,2.11523117173632,1.08081534282154,1.85917429641708e-11,1.38776137110266e-10,"up","yes","AF117829.1","lincRNA","chr8:89609409-89757727:-",".",".",".",".","gi|666670333|tpe|LK939030.1|",3802,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000375481.1 (RP11-37B2.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.",".",".",".",".","."]
["ENSG00000141505",123,106,125,93.5561675123385,48,59,95,2.11394649556901,1.07993886226738,3.70923591562858e-07,1.88719974520295e-06,"up","yes","ASGR1","protein_coding","chr17:7173431-7179564:-","gi|675658396|ref|XP_008994872.1|",293,2e-27,"PREDICTED: asialoglycoprotein receptor 1 isoform X2 [Callithrix jacchus]","gi|34530045|dbj|AK124286.1|",2074,0,"Homo sapiens cDNA FLJ42292 fis, clone TLIVE2007816","P07306",109,1e-24,"Asialoglycoprotein receptor 1",".",".",".",".","pfam03954","Lectin_N","Hepatic lectin, N-terminal domain.","GO:0031668|cellular response to extracellular stimulus;GO:0018279|protein N-linked glycosylation via asparagine;GO:0006898|receptor-mediated endocytosis;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0004873|asialoglycoprotein receptor activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;","K10063","ASGR1; asialoglycoprotein receptor 1"]
["ENSG00000074935",910,865,830,689.310057071282,379,491,604,2.1087579125122,1.07639348182438,4.61455822900789e-44,1.18358509469553e-42,"up","yes","TUBE1","protein_coding","chr6:112070777-112087529:-","gi|635076990|ref|XP_008005486.1|",382,1e-35,"PREDICTED: tubulin epsilon chain isoform X2 [Chlorocebus sabaeus]","gi|380244626|emb|Z99289.2|",3610,0,"Human DNA sequence from clone RP1-142L7 on chromosome 6q21, complete sequence","Q9UJT0",115,1e-25,"Tubulin epsilon chain",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007098|centrosome cycle;","GO:0005874|microtubule;GO:0000242|pericentriolar material;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K10391","TUBE; tubulin epsilon"]
["ENSG00000116254",69,62,41,45.2229801637855,28,25,44,2.10708876712834,1.07525109308179,0.000457219937121075,0.00158185796362176,"up","yes","CHD5","protein_coding","chr1:6101793-6180123:-","gi|24308089|ref|NP_056372.1|",8329,0,"chromodomain-helicase-DNA-binding protein 5 [Homo sapiens]","gi|304361774|ref|NM_015557.2|",9646,0,"Homo sapiens chromodomain helicase DNA binding protein 5 (CHD5), mRNA","Q8TDI0",3212,0,"Chromodomain-helicase-DNA-binding protein 5",".",".",".",".","pfam08074","CHDCT2","CHDCT2 (NUC038) domain. The CHDCT2 C-terminal domain is found in PHD/RING finger and chromo domain-associated CHD-like helicases.","GO:0021895|cerebral cortex neuron differentiation;GO:0098532|histone H3-K27 trimethylation;GO:0043967|histone H4 acetylation;GO:0008285|negative regulation of cell proliferation;GO:1901798|positive regulation of signal transduction by p53 class mediator;GO:0060850|regulation of transcription involved in cell fate commitment;GO:0035093|spermatogenesis, exchange of chromosomal proteins;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0000792|heterochromatin;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016581|NuRD complex;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0061628|H3K27me3 modified histone binding;GO:0004386|helicase activity;GO:0046872|metal ion binding;","K14435","CHD5; chromodomain-helicase-DNA-binding protein 5 [EC:3.6.4.12]"]
["ENSG00000164400",81,96,82,68.677051086132,35,54,58,2.10707599386328,1.0752423473743,9.06198755163859e-06,3.97515614955663e-05,"up","yes","CSF2","protein_coding","chr5:132073790-132076170:+","gi|27437030|ref|NP_000749.2|",638,7e-81,"granulocyte-macrophage colony-stimulating factor precursor [Homo sapiens]","gi|371502128|ref|NM_000758.3|",785,0,"Homo sapiens colony stimulating factor 2 (CSF2), mRNA","P04141",250,2e-82,"Granulocyte-macrophage colony-stimulating factor",".",".",".",".","pfam01109","GM_CSF","Granulocyte-macrophage colony-stimulating factor.","GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:0071222|cellular response to lipopolysaccharide;GO:0019221|cytokine-mediated signaling pathway;GO:0097028|dendritic cell differentiation;GO:0001892|embryonic placenta development;GO:0042045|epithelial fluid transport;GO:0001821|histamine secretion;GO:0006955|immune response;GO:0042116|macrophage activation;GO:0000165|MAPK cascade;GO:0030224|monocyte differentiation;GO:0043011|myeloid dendritic cell differentiation;GO:0045918|negative regulation of cytolysis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030223|neutrophil differentiation;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0032747|positive regulation of interleukin-23 production;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0071803|positive regulation of podosome assembly;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0045637|regulation of myeloid cell differentiation;GO:0034405|response to fluid shear stress;GO:0034021|response to silicon dioxide;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043231|intracellular membrane-bounded organelle;","GO:0005125|cytokine activity;GO:0005129|granulocyte macrophage colony-stimulating factor receptor binding;GO:0008083|growth factor activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K05427","CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor"]
["ENSG00000221843",86,76,57,57.762755205886,34,42,47,2.10431952342492,1.07335378251102,4.63649121196568e-05,0.000185114143027104,"up","yes","C2orf16","protein_coding","chr2:27537386-27582721:+","gi|544482229|ref|XP_005576322.1|",22220,0,"PREDICTED: uncharacterized protein C2orf16 homolog [Macaca fascicularis]","gi|21263357|gb|AC109829.4|",11347,0,"Homo sapiens BAC clone RP11-1217F14 from 2, complete sequence","Q68DN1",3212,0,"Uncharacterized protein C2orf16",".",".",".",".","pfam08017","Fibrinogen_BP","Fibrinogen binding protein. Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.",".","GO:0070062|extracellular exosome;GO:0005634|nucleus;",".",".","."]
["ENSG00000198205",166,160,161,129.409787575848,82,89,103,2.10371443773792,1.07293888370839,9.68468502776884e-10,6.28738488103687e-09,"up","yes","ZXDA","protein_coding","chrX:57906708-57910820:-","gi|795099505|ref|XP_011829054.1|",3451,0,"PREDICTED: zinc finger X-linked protein ZXDB [Mandrillus leucophaeus]","gi|270297170|ref|NG_015974.1|",4113,0,"Homo sapiens zinc finger, X-linked, duplicated A (ZXDA), RefSeqGene on chromosome X","P98168",1306,0,"Zinc finger X-linked protein ZXDA","SPAC144.09c",105,4e-23,"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0045893|positive regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0070742|C2H2 zinc finger domain binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0003676|nucleic acid binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000162772",406,414,364,313.446550668156,173,214,286,2.10276624936428,1.07228848410387,7.30875881937314e-21,9.02505378412735e-20,"up","yes","ATF3","protein_coding","chr1:212565334-212620777:+","gi|640832260|ref|XP_008071761.1|",331,9e-33,"PREDICTED: cyclic AMP-dependent transcription factor ATF-3 isoform X2 [Tarsius syrichta]","gi|34531289|dbj|AK125255.1|",2086,0,"Homo sapiens cDNA FLJ43265 fis, clone HLUNG2018626, highly  similar to Rattus norvegicus Activating transcription factor 3 (Atf3)","Q2KII1",131,2e-33,"Cyclic AMP-dependent transcription factor ATF-3",".",".",".",".","pfam11017","DUF2855","Protein of unknown function (DUF2855). This family of proteins has no known function.","GO:0034198|cellular response to amino acid starvation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0006094|gluconeogenesis;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0035914|skeletal muscle cell differentiation;GO:0006351|transcription, DNA-templated;","GO:1990622|CHOP-ATF3 complex;GO:0005730|nucleolus;","GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09032","ATF3, LRF1; activating transcription factor 3"]
["ENSG00000260793",34,50,41,33.4406038424019,27,15,28,2.10205840737339,1.07180275629213,0.00359781037958407,0.0105543067074399,"up","yes","AC003102.1","antisense","chr17:44221401-44223710:+","gi|119572000|gb|EAW51615.1|",547,3e-63,"hCG2036783, partial [Homo sapiens]","gi|551885938|tpe|HG509087.1|",1796,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000431419.2 (RP5-882C2.2 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000253846",30,29,32,24.2758431441958,17,16,18,2.10107345927869,1.07112660345998,0.00754088633927166,0.0206310093208329,"up","yes","PCDHGA10","protein_coding","chr5:141412987-141512979:+","gi|11128041|ref|NP_061736.1|",4661,0,"protocadherin gamma-A10 isoform 1 precursor [Homo sapiens]","gi|14196446|ref|NM_018913.2|",4617,0,"Homo sapiens protocadherin gamma subfamily A, 10 (PCDHGA10), transcript variant 1, mRNA","Q9Y5H3",1799,0,"Protocadherin gamma-A10",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399|nervous system development;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16495","PCDHGA; protocadherin gamma subfamily A"]
["ENSG00000113369",425,379,424,325.853747217925,191,201,308,2.0993675235389,1.06995475261039,4.88653403605313e-19,5.59024131004702e-18,"up","yes","ARRDC3","protein_coding","chr5:91368724-91383359:-","gi|28972730|dbj|BAC65781.1|",2255,0,"mKIAA1376 protein [Mus musculus]","gi|195539387|ref|NM_020801.2|",4161,0,"Homo sapiens arrestin domain containing 3 (ARRDC3), mRNA","Q96B67",862,0,"Arrestin domain-containing protein 3",".",".",".",".","pfam00339","Arrestin_N","Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.","GO:0060613|fat pad development;GO:0071878|negative regulation of adrenergic receptor signaling pathway;GO:0031651|negative regulation of heat generation;GO:0090327|negative regulation of locomotion involved in locomotory behavior;GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0007165|signal transduction;GO:0043588|skin development;GO:0001659|temperature homeostasis;","GO:0005769|early endosome;GO:0005768|endosome;GO:0005764|lysosome;GO:0005886|plasma membrane;","GO:0031699|beta-3 adrenergic receptor binding;",".","."]
["ENSG00000163596",92,67,68,60.1840504963202,43,42,41,2.09916049478882,1.06981247448339,5.94738497027265e-05,0.000233774528849845,"up","yes","ICA1L","protein_coding","chr2:202773150-202871985:-","gi|22095388|ref|NP_612477.3|",2444,0,"islet cell autoantigen 1-like protein isoform 1 [Homo sapiens]","gi|568599858|ref|NM_001288623.1|",8151,0,"Homo sapiens islet cell autoantigen 1 like (ICA1L), transcript variant 4, mRNA","Q8NDH6",946,0,"Islet cell autoantigen 1-like protein",".",".",".",".","pfam06456","Arfaptin","Arfaptin-like domain. Arfaptin interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.","GO:0007286|spermatid development;","GO:0001669|acrosomal vesicle;","GO:0019904|protein domain specific binding;",".","."]
["ENSG00000230257",87,75,65,59.6476578124704,22,43,67,2.09647100532549,1.0679628775192,0.000102073405311106,0.000389012416842643,"up","yes","NFE4","protein_coding","chr7:102973437-102988856:+","gi|119603715|gb|EAW83309.1|",416,4e-47,"hCG2036754, partial [Homo sapiens]","gi|551862349|tpe|HG500464.1|",1072,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000347927.1 (RP11-645N11.2 gene), antisense","Q86UQ8",132,2e-35,"Transcription factor NF-E4",".",".",".",".","pfam11045","YbjM","Putative inner membrane protein of Enterobacteriaceae. This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0065003|macromolecular complex assembly;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042803|protein homodimerization activity;GO:0000987|core promoter proximal region sequence-specific DNA binding;",".","."]
["ENSG00000111275",1362,1405,1283,1074.90177954683,618,728,960,2.0959679591614,1.06761666271875,2.89534303100553e-57,9.61194085749304e-56,"up","yes","ALDH2","protein_coding","chr12:111766887-111817529:+","gi|25777732|ref|NP_000681.2|",2647,0,"aldehyde dehydrogenase, mitochondrial isoform 1 precursor [Homo sapiens]","gi|29126252|gb|AC003029.5|",7987,0,"Homo sapiens 12 PAC RP3-462E2 (Roswell Park Cancer institute Human PAC Library) complete sequence","P05091",1024,0,"Aldehyde dehydrogenase, mitochondrial","SPAC9E9.09c",535,3e-168,"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006066|alcohol metabolic process;GO:0005975|carbohydrate metabolic process;GO:0006068|ethanol catabolic process;GO:0006069|ethanol oxidation;","GO:0070062|extracellular exosome;GO:0005759|mitochondrial matrix;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity;GO:0009055|electron carrier activity;GO:0051287|NAD binding;","K00128","E1.2.1.3; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]"]
["ENSG00000128342",4572,4340,4159,3470.69588376072,2059,2460,2894,2.09264134216686,1.0653250692543,2.6264439442233e-148,2.94528202303366e-146,"up","yes","LIF","protein_coding","chr22:30240447-30246851:-","gi|4504991|ref|NP_002300.1|",903,4e-109,"leukemia inhibitory factor isoform 1 precursor [Homo sapiens]","gi|380418322|ref|NM_002309.4|",3969,0,"Homo sapiens leukemia inhibitory factor (LIF), transcript variant 1, mRNA","P15018",352,1e-110,"Leukemia inhibitory factor",".",".",".",".","pfam01291","LIF_OSM","LIF / OSM family.","GO:0001974|blood vessel remodeling;GO:0019221|cytokine-mediated signaling pathway;GO:0046697|decidualization;GO:0007566|embryo implantation;GO:0006955|immune response;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0048286|lung alveolus development;GO:0060463|lung lobe morphogenesis;GO:0060426|lung vasculature development;GO:0007275|multicellular organismal development;GO:0048644|muscle organ morphogenesis;GO:0008285|negative regulation of cell proliferation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0046888|negative regulation of hormone secretion;GO:0045835|negative regulation of meiotic nuclear division;GO:0048666|neuron development;GO:0048711|positive regulation of astrocyte differentiation;GO:0008284|positive regulation of cell proliferation;GO:1901676|positive regulation of histone H3-K27 acetylation;GO:0045651|positive regulation of macrophage differentiation;GO:0043410|positive regulation of MAPK cascade;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033141|positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:1900182|positive regulation of protein localization to nucleus;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:1903025|regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:0060708|spongiotrophoblast differentiation;GO:0048863|stem cell differentiation;GO:0019827|stem cell population maintenance;GO:0060707|trophoblast giant cell differentiation;GO:0007260|tyrosine phosphorylation of STAT protein;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005146|leukemia inhibitory factor receptor binding;GO:0005102|receptor binding;","K05419","LIF; leukemia inhibitory factor"]
["ENSG00000063438",480,421,374,337.519882720582,194,240,290,2.0916829171201,1.06466416680003,6.15333012453359e-22,7.99228494558948e-21,"up","yes","AHRR","protein_coding","chr5:304176-438291:+","gi|115430245|ref|NP_065782.2|",3299,0,"aryl hydrocarbon receptor repressor isoform 1 [Homo sapiens]","gi|334848121|ref|NM_020731.4|",5661,0,"Homo sapiens aryl-hydrocarbon receptor repressor (AHRR), transcript variant 1, mRNA","A9YTQ3",1224,0,"Aryl hydrocarbon receptor repressor",".",".",".",".","pfam00989","PAS","PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.","GO:0009410|response to xenobiotic stimulus;GO:0006351|transcription, DNA-templated;GO:0006805|xenobiotic metabolic process;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0046983|protein dimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001191|transcriptional repressor activity, RNA polymerase II transcription factor binding;","K09094","AHRR, AHH; aryl hydrocarbon receptor repressor"]
["ENSG00000173157",31,33,26,23.8777737906113,12,22,17,2.0914267710552,1.06448748452986,0.00901113984765081,0.0241868724438476,"up","yes","ADAMTS20","protein_coding","chr12:43353866-43551921:-","gi|124430557|ref|NP_079279.3|",10216,0,"A disintegrin and metalloproteinase with thrombospondin motifs 20 preproprotein [Homo sapiens]","gi|767975357|ref|XM_011538754.1|",6068,0,"PREDICTED: Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 20 (ADAMTS20), transcript variant X1, mRNA","P59510",3935,0,"A disintegrin and metalloproteinase with thrombospondin motifs 20",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:0045636|positive regulation of melanocyte differentiation;GO:0009967|positive regulation of signal transduction;","GO:0005615|extracellular space;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K09609","ADAMTS20; a disintegrin and metalloproteinase with thrombospondin motifs 20 [EC:3.4.24.-]"]
["ENSG00000174951",279,209,206,183.216449621447,85,154,158,2.08829572745259,1.06232602911035,7.21542938993467e-11,5.1678871917215e-10,"up","yes","FUT1","protein_coding","chr19:48748011-48755390:-","gi|578834235|ref|XP_006723190.1|",2228,0,"PREDICTED: galactoside 2-alpha-L-fucosyltransferase 1 isoform X1 [Homo sapiens]","gi|171906616|ref|NM_000148.3|",4246,0,"Homo sapiens fucosyltransferase 1 (H blood group) (FUT1), mRNA","P19526",756,0,"Galactoside 2-alpha-L-fucosyltransferase 1",".",".",".",".","pfam01531","Glyco_transf_11","Glycosyl transferase family 11. This family contains several fucosyl transferase enzymes.","GO:0005975|carbohydrate metabolic process;GO:0042355|L-fucose catabolic process;GO:0006486|protein glycosylation;","GO:0005794|Golgi apparatus;GO:0032580|Golgi cisterna membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0008417|fucosyltransferase activity;GO:0008107|galactoside 2-alpha-L-fucosyltransferase activity;","K00718","FUT1_2; galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]"]
["ENSG00000246763",80,74,81,62.6862290490905,47,30,56,2.08794546443004,1.06208403028719,6.97269947349454e-05,0.000270984137507078,"up","yes","RGMB-AS1","antisense","chr5:98769618-98773469:-","gi|685546728|ref|XP_009207095.1|",560,8e-65,"PREDICTED: uncharacterized protein LOC103885274 [Papio anubis]","gi|551856818|tpe|HG498276.1|",2034,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000370291.1 (CTC-463N11.3 gene), antisense",".",".",".",".",".",".",".",".","pfam04621","ETS_PEA3_N","PEA3 subfamily ETS-domain transcription factor N terminal domain. The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.",".",".",".",".","."]
["ENSG00000166592",26,25,21,19.0945652287972,10,16,15,2.08528508241554,1.06024463013135,0.0178878752198859,0.0446340669134746,"up","yes","RRAD","protein_coding","chr16:66921679-66925644:-","gi|426382565|ref|XP_004057875.1|",1270,3e-168,"PREDICTED: GTP-binding protein RAD [Gorilla gorilla gorilla]","gi|694964013|ref|XM_001143391.4|",1513,0,"PREDICTED: Pan troglodytes Ras-related associated with diabetes (RRAD), transcript variant X1, mRNA","P55042",484,6e-168,"GTP-binding protein RAD",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:1901842|negative regulation of high voltage-gated calcium channel activity;GO:0007264|small GTPase mediated signal transduction;","GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005516|calmodulin binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07845","RRAD, RAD1; Ras-related associated with diabetes"]
["ENSG00000230724",43,19,36,25.9547302910668,17,13,26,2.08343765535039,1.05896592957608,0.0111637700947758,0.0293801060974259,"up","yes","LINC01001","lincRNA","chr11:127204-139612:-","gi|194375846|dbj|BAG57267.1|",1750,0,"unnamed protein product [Homo sapiens]","gi|551869807|tpe|HG503395.1|",2553,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000381923.2 (RP11-304M2.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000268655",87,78,71,62.617370393993,38,39,58,2.08122358087758,1.05743195868057,2.17828302884665e-05,9.12944797670299e-05,"up","yes","AC008687.4","protein_coding","chr19:49017496-49020523:-","gi|119572818|gb|EAW52433.1|",1536,0,"hCG1796489 [Homo sapiens]","gi|931607401|ref|XM_014342774.1|",1117,0,"PREDICTED: Pan paniscus uncharacterized LOC100985533 (LOC100985533), mRNA",".",".",".",".",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSG00000151322",52,61,50,43.4856606197623,30,24,39,2.07920806140647,1.0560341324821,0.000549229392988451,0.00187595830210045,"up","yes","NPAS3","protein_coding","chr14:32934933-33804176:+","gi|11545847|ref|NP_071406.1|",3698,0,"neuronal PAS domain-containing protein 3 isoform 2 [Homo sapiens]","gi|194595496|ref|NM_022123.2|",5837,0,"Homo sapiens neuronal PAS domain protein 3 (NPAS3), transcript variant 2, mRNA","Q8IXF0",1407,0,"Neuronal PAS domain-containing protein 3",".",".",".",".","pfam08447","PAS_3","PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.","GO:0032502|developmental process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046983|protein dimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09098","NPAS1_3; neuronal PAS domain-containing protein 1/3"]
["ENSG00000168159",3001,2970,2864,2350.79681676672,1278,1644,2178,2.07703751703474,1.05452727547536,3.71299724950083e-91,2.17678695891708e-89,"up","yes","RNF187","protein_coding","chr1:228487061-228495766:+","gi|426334105|ref|XP_004028603.1|",1023,3e-125,"PREDICTED: E3 ubiquitin-protein ligase RNF187 [Gorilla gorilla gorilla]","gi|256225837|ref|NM_001010858.2|",2711,0,"Homo sapiens ring finger protein 187 (RNF187), mRNA","Q5TA31",344,5e-109,"E3 ubiquitin-protein ligase RNF187",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.","GO:0008284|positive regulation of cell proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865|protein autoubiquitination;GO:0070936|protein K48-linked ubiquitination;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0004842|ubiquitin-protein transferase activity;","K15709","RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27]"]
["ENSG00000182568",598,512,514,432.486822066808,292,287,341,2.07651352205671,1.05416326648491,9.94013055097124e-23,1.33327703801901e-21,"up","yes","SATB1","protein_coding","chr3:18345387-18445588:-","gi|4506791|ref|NP_002962.1|",3770,0,"DNA-binding protein SATB1 isoform 1 [Homo sapiens]","gi|426339650|ref|XM_004033709.1|",6553,0,"PREDICTED: Gorilla gorilla gorilla SATB homeobox 1, transcript variant 2 (SATB1), mRNA","Q01826",1454,0,"DNA-binding protein SATB1",".",".",".",".","pfam02376","CUT","CUT domain. The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.","GO:0050798|activated T cell proliferation;GO:0043367|CD4-positive, alpha-beta T cell differentiation;GO:0043374|CD8-positive, alpha-beta T cell differentiation;GO:0006325|chromatin organization;GO:0006338|chromatin remodeling;GO:0008544|epidermis development;GO:0016571|histone methylation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0060004|reflex;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:0016604|nuclear body;GO:0005720|nuclear heterochromatin;GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;","GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["ENSG00000265778",38,22,22,21.575957513292,11,16,20,2.07624225633392,1.05397478744377,0.0145873695073779,0.0372960210840807,"up","yes","AC018413.1","antisense","chr18:76491652-76493918:+","gi|578832857|ref|XP_006722657.1|",626,6e-76,"PREDICTED: uncharacterized protein LOC101927989 isoform X2 [Homo sapiens]","gi|666670812|tpe|HG510155.2|",1200,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000444934.2 (RP11-17M16.2 gene), antisense",".",".",".",".",".",".",".",".","pfam01655","Ribosomal_L32e","Ribosomal protein L32. This family includes ribosomal protein L32 from eukaryotes and archaebacteria.",".",".",".",".","."]
["ENSG00000198569",51,41,31,32.5192124154942,19,24,27,2.07612167130156,1.05389099544901,0.00250619184562941,0.00760053904378931,"up","yes","SLC34A3","protein_coding","chr9:137230757-137236554:+","gi|313104149|sp|Q8N130.2|NPT2C_HUMAN",2449,0,"RecName: Full=Sodium-dependent phosphate transport protein 2C; Short=Sodium-phosphate transport protein 2C; AltName: Full=Na(+)-dependent phosphate cotransporter 2C; AltName: Full=Sodium/inorganic phosphate cotransporter IIC; AltName: Full=Sodium/phosphate cotransporter 2C; Short=Na(+)/Pi cotransporter 2C; Short=NaPi-2c; AltName: Full=Solute carrier family 34 member 3","gi|293597524|ref|NM_001177317.1|",2159,0,"Homo sapiens solute carrier family 34 member 3 (SLC34A3), transcript variant 2, mRNA","Q8N130",947,0,"Sodium-dependent phosphate transport protein 2C","VC0676",80.5,2e-15,"COG1283","pfam02690","Na_Pi_cotrans","Na+/Pi-cotransporter. This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.","GO:0030643|cellular phosphate ion homeostasis;GO:0006817|phosphate ion transport;GO:0006814|sodium ion transport;","GO:0016324|apical plasma membrane;GO:0005903|brush border;GO:0031526|brush border membrane;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0031982|vesicle;","GO:0015321|sodium-dependent phosphate transmembrane transporter activity;GO:0005436|sodium:phosphate symporter activity;","K14683","SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter)"]
["ENSG00000259230",57,38,46,37.2731039577996,19,22,41,2.07515862770708,1.0532216220785,0.00158625371188954,0.00500583468503361,"up","yes","LINC02323","lincRNA","chr14:102545254-102555826:+",".",".",".",".","gi|767982919|ref|XR_944241.1|",1603,0,"PREDICTED: Homo sapiens uncharacterized LOC105370681 (LOC105370681), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSG00000103742",905,832,791,672.909614413124,426,426,595,2.07341097021526,1.05200610097598,1.53080139947012e-35,3.17143903254347e-34,"up","yes","IGDCC4","protein_coding","chr15:65381464-65423072:-","gi|19882241|ref|NP_066013.1|",5835,0,"immunoglobulin superfamily DCC subclass member 4 precursor [Homo sapiens]","gi|734703847|ref|NM_020962.2|",6485,0,"Homo sapiens immunoglobulin superfamily, DCC subclass, member 4 (IGDCC4), mRNA","Q8TDY8",2253,0,"Immunoglobulin superfamily DCC subclass member 4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000178607",1094,1086,1036,856.598746276015,495,589,767,2.07292077919549,1.05166498203068,5.03869670884775e-49,1.43554478759609e-47,"up","yes","ERN1","protein_coding","chr17:64039142-64130819:-","gi|62089324|dbj|BAD93106.1|",4772,0,"endoplasmic reticulum to nucleus signalling 1 isoform 1 variant [Homo sapiens]","gi|694969111|ref|XM_511585.5|",7717,0,"PREDICTED: Pan troglodytes endoplasmic reticulum to nucleus signaling 1 (ERN1), mRNA","O75460",1796,0,"Serine/threonine-protein kinase/endoribonuclease IRE1",".",".",".",".","pfam06479","Ribonuc_2-5A","Ribonuclease 2-5A. This domain is a endoribonuclease. Specifically it cleaves an intron from Hac1 mRNA in humans, which causes it to be much more efficiently translated.","GO:0007257|activation of JUN kinase activity;GO:0007050|cell cycle arrest;GO:0071333|cellular response to glucose stimulus;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0001935|endothelial cell proliferation;GO:1901142|insulin metabolic process;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0036498|IRE1-mediated unfolded protein response;GO:0006402|mRNA catabolic process;GO:0098787|mRNA cleavage involved in mRNA processing;GO:0070054|mRNA splicing, via endonucleolytic cleavage and ligation;GO:0036289|peptidyl-serine autophosphorylation;GO:1990579|peptidyl-serine trans-autophosphorylation;GO:1900103|positive regulation of endoplasmic reticulum unfolded protein response;GO:0033120|positive regulation of RNA splicing;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0016241|regulation of macroautophagy;GO:0006355|regulation of transcription, DNA-templated;GO:0034976|response to endoplasmic reticulum stress;GO:0006351|transcription, DNA-templated;","GO:1990597|AIP1-IRE1 complex;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:1990332|Ire1 complex;GO:1990630|IRE1-RACK1-PP2A complex;GO:1990604|IRE1-TRAF2-ASK1 complex;GO:0005739|mitochondrion;GO:0005637|nuclear inner membrane;","GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0004521|endoribonuclease activity;GO:0019899|enzyme binding;GO:0030544|Hsp70 protein binding;GO:0051879|Hsp90 protein binding;GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0042803|protein homodimerization activity;GO:0004674|protein serine/threonine kinase activity;","K08852","ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]"]
["ENSG00000164463",1719,1470,1493,1246.32195432037,752,894,1032,2.0713033624148,1.05053886567824,9.15706842739536e-62,3.27683739939892e-60,"up","yes","CREBRF","protein_coding","chr5:173056352-173139284:+","gi|270309176|ref|NP_705835.2|",2998,0,"CREB3 regulatory factor isoform 1 [Homo sapiens]","gi|270309175|ref|NM_153607.2|",7778,0,"Homo sapiens CREB3 regulatory factor (CREBRF), transcript variant 1, mRNA","Q8IUR6",1159,0,"CREB3 regulatory factor",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0030968|endoplasmic reticulum unfolded protein response;GO:0042711|maternal behavior;GO:1900102|negative regulation of endoplasmic reticulum unfolded protein response;GO:1900170|negative regulation of glucocorticoid mediated signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032388|positive regulation of intracellular transport;GO:1902213|positive regulation of prolactin signaling pathway;GO:0045732|positive regulation of protein catabolic process;GO:0051222|positive regulation of protein transport;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0034976|response to endoplasmic reticulum stress;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["ENSG00000124813",521,550,508,421.838377741269,280,273,349,2.07025175555014,1.04980621912495,2.03648000835509e-22,2.69777653854073e-21,"up","yes","RUNX2","protein_coding","chr6:45328157-45664349:+","gi|966939084|ref|XP_014991973.1|",1408,1e-175,"PREDICTED: runt-related transcription factor 2 isoform X3 [Macaca mulatta]","gi|767940885|ref|XM_011514961.1|",4217,0,"PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X1, mRNA","Q13950",516,4e-163,"Runt-related transcription factor 2",".",".",".",".","pfam00853","Runt","Runt domain.","GO:0030509|BMP signaling pathway;GO:0048469|cell maturation;GO:0071773|cellular response to BMP stimulus;GO:0002063|chondrocyte development;GO:0002062|chondrocyte differentiation;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0001958|endochondral ossification;GO:0030097|hemopoiesis;GO:0045879|negative regulation of smoothened signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030182|neuron differentiation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0001503|ossification;GO:0002076|osteoblast development;GO:0001649|osteoblast differentiation;GO:0002051|osteoblast fate commitment;GO:0008284|positive regulation of cell proliferation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045595|regulation of cell differentiation;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0042487|regulation of odontogenesis of dentin-containing tooth;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0048863|stem cell differentiation;GO:0030217|T cell differentiation;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005829|cytosol;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0005524|ATP binding;GO:0043425|bHLH transcription factor binding;GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019904|protein domain specific binding;GO:0070491|repressing transcription factor binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09278","RUNX2, AML3; runt-related transcription factor 2"]
["ENSG00000067064",2277,2209,2008,1730.02212494311,1019,1202,1519,2.06616839621591,1.04695784107865,3.20550157817627e-89,1.84560341611534e-87,"up","yes","IDI1","protein_coding","chr10:1039152-1049170:-","gi|48257064|gb|AAH05247.2|",1207,4e-154,"IDI1 protein, partial [Homo sapiens]","gi|964748906|ref|NM_001317956.1|",3103,0,"Homo sapiens isopentenyl-diphosphate delta isomerase 1 (IDI1), transcript variant 3, mRNA","Q13907",449,8e-148,"Isopentenyl-diphosphate Delta-isomerase 1","SPBC106.15",222,1e-64,"COG1443","pfam00293","NUDIX","NUDIX domain.","GO:0006695|cholesterol biosynthetic process;GO:0050992|dimethylallyl diphosphate biosynthetic process;GO:0009240|isopentenyl diphosphate biosynthetic process;GO:0008299|isoprenoid biosynthetic process;GO:0045540|regulation of cholesterol biosynthetic process;","GO:0005829|cytosol;GO:0005777|peroxisome;","GO:0016787|hydrolase activity;GO:0004452|isopentenyl-diphosphate delta-isomerase activity;GO:0000287|magnesium ion binding;GO:0030145|manganese ion binding;GO:0046872|metal ion binding;","K01823","idi, IDI; isopentenyl-diphosphate delta-isomerase [EC:5.3.3.2]"]
["ENSG00000154065",394,368,369,301.595504210924,173,220,259,2.06536284498214,1.0463952579989,5.73374564312556e-20,6.85207471899664e-19,"up","yes","ANKRD29","protein_coding","chr18:23598926-23662885:-","gi|940772094|ref|XP_014302267.1|",548,3e-98,"PREDICTED: ankyrin repeat domain-containing protein 29 [Myotis lucifugus]","gi|34528683|dbj|AK123197.1|",3579,0,"Homo sapiens cDNA FLJ41203 fis, clone BRACE3000071",".",".",".",".","all2748",82.4,2e-26,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSG00000164418",73,47,47,44.2884312196737,27,35,33,2.06385840506412,1.04534399531587,0.000639232091312687,0.00216155479965623,"up","yes","GRIK2","protein_coding","chr6:101181257-102070083:+","gi|11386137|ref|NP_068775.1|",4744,0,"glutamate receptor ionotropic, kainate 2 isoform 1 precursor [Homo sapiens]","gi|694917433|ref|XM_009451672.1|",4810,0,"PREDICTED: Pan troglodytes glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant X4, mRNA","Q13002",1831,0,"Glutamate receptor ionotropic, kainate 2",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001662|behavioral fear response;GO:0006874|cellular calcium ion homeostasis;GO:0007268|synaptic transmission;GO:0007215|glutamate receptor signaling pathway;GO:0060080|inhibitory postsynaptic potential;GO:0006886|intracellular protein transport;GO:0050804|modulation of synaptic transmission;GO:0043524|negative regulation of neuron apoptotic process;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0051402|neuron apoptotic process;GO:0019228|neuronal action potential;GO:0043525|positive regulation of neuron apoptotic process;GO:0050806|positive regulation of synaptic transmission;GO:0043113|receptor clustering;GO:0046328|regulation of JNK cascade;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0035249|synaptic transmission, glutamatergic;","GO:0030054|cell junction;GO:0032839|dendrite cytoplasm;GO:0005887|integral component of plasma membrane;GO:0032983|kainate selective glutamate receptor complex;GO:0043204|perikaryon;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0042734|presynaptic membrane;GO:0043195|terminal bouton;","GO:0005234|extracellular-glutamate-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0030165|PDZ domain binding;GO:0042803|protein homodimerization activity;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031625|ubiquitin protein ligase binding;","K05202","GRIK2; glutamate receptor, ionotropic kainate 2"]
["ENSG00000108771",184,186,149,138.58112853166,89,103,105,2.05776436780924,1.04107779036808,2.35937654704904e-09,1.47704170202798e-08,"up","yes","DHX58","protein_coding","chr17:42101404-42112733:-","gi|149408122|ref|NP_077024.2|",3389,0,"probable ATP-dependent RNA helicase DHX58 [Homo sapiens]","gi|149408121|ref|NM_024119.2|",2617,0,"Homo sapiens DEXH-box helicase 58 (DHX58), mRNA","Q96C10",1308,0,"Probable ATP-dependent RNA helicase DHX58","PAB0190_1",120,7e-28,"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0051607|defense response to virus;GO:0045087|innate immune response;GO:0045824|negative regulation of innate immune response;GO:0039534|negative regulation of MDA-5 signaling pathway;GO:0039536|negative regulation of RIG-I signaling pathway;GO:0032480|negative regulation of type I interferon production;GO:1900245|positive regulation of MDA-5 signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0045088|regulation of innate immune response;GO:0009615|response to virus;GO:0016032|viral process;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;GO:0004386|helicase activity;GO:0003727|single-stranded RNA binding;GO:0008270|zinc ion binding;","K12649","DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:3.6.3.14]"]
["ENSG00000178105",2261,1968,1947,1646.48975798023,976,1142,1452,2.05719661146503,1.0406796824533,5.98883618011653e-82,3.00814250630437e-80,"up","yes","DDX10","protein_coding","chr11:108665025-108940930:+","gi|62089354|dbj|BAD93121.1|",3779,0,"DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 variant [Homo sapiens]","gi|62089353|dbj|AB209884.1|",6682,0,"Homo sapiens mRNA for DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 variant protein","Q13206",1418,0,"Probable ATP-dependent RNA helicase DDX10","SPAC1093.05",553,5e-173,"COG0513","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0097065|anterior head development;GO:0010501|RNA secondary structure unwinding;","GO:0005737|cytoplasm;GO:0005730|nucleolus;","GO:0005524|ATP binding;GO:0004004|ATP-dependent RNA helicase activity;GO:0003723|RNA binding;GO:0003724|RNA helicase activity;","K14776","DDX10, DBP4; ATP-dependent RNA helicase DDX10/DBP4 [EC:3.6.4.13]"]
["ENSG00000183426",179,174,184,143.606936334078,85,91,137,2.05338714184798,1.03800565616985,8.24794804824013e-10,5.39492128484132e-09,"up","yes","NPIPA1","protein_coding","chr16:14922802-14952060:+","gi|47077679|dbj|BAD18720.1|",2743,0,"FLJ00322 protein [Homo sapiens]","gi|47077678|dbj|AK160377.1|",5334,0,"Homo sapiens mRNA for FLJ00322 protein","P98161",977,0,"Polycystin-1",".",".",".",".","pfam06409","NPIP","Nuclear pore complex interacting protein (NPIP). This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.","GO:0009653|anatomical structure morphogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0070588|calcium ion transmembrane transport;GO:0007161|calcium-independent cell-matrix adhesion;GO:0001502|cartilage condensation;GO:0051216|cartilage development;GO:0007050|cell cycle arrest;GO:0007160|cell-matrix adhesion;GO:0042994|cytoplasmic sequestering of transcription factor;GO:0050982|detection of mechanical stimulus;GO:0048565|digestive tract development;GO:0001892|embryonic placenta development;GO:0030010|establishment of cell polarity;GO:0048806|genitalia development;GO:0007507|heart development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0001701|in utero embryonic development;GO:0007259|JAK-STAT cascade;GO:0001822|kidney development;GO:0001889|liver development;GO:0060428|lung epithelium development;GO:0036303|lymph vessel morphogenesis;GO:0072177|mesonephric duct development;GO:0072164|mesonephric tubule development;GO:0072218|metanephric ascending thin limb development;GO:0072205|metanephric collecting duct development;GO:0072287|metanephric distal tubule morphogenesis;GO:0072237|metanephric proximal tubule development;GO:0021915|neural tube development;GO:0018105|peptidyl-serine phosphorylation;GO:0060674|placenta blood vessel development;GO:0031659|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0032092|positive regulation of protein binding;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006611|protein export from nucleus;GO:0030155|regulation of cell adhesion;GO:0060236|regulation of mitotic spindle organization;GO:0061136|regulation of proteasomal protein catabolic process;GO:0034405|response to fluid shear stress;GO:0043588|skin development;GO:0021510|spinal cord development;","GO:0016323|basolateral plasma membrane;GO:0009986|cell surface;GO:0060170|ciliary membrane;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0000139|Golgi membrane;GO:0030660|Golgi-associated vesicle membrane;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0016328|lateral plasma membrane;GO:0031514|motile cilium;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0002133|polycystin complex;","GO:0005262|calcium channel activity;GO:0030246|carbohydrate binding;GO:0044325|ion channel binding;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;","K04985","PKD1; polycystin 1"]
["ENSG00000111886",48,38,35,32.1809294796193,20,20,30,2.05311420162343,1.0378138775846,0.00276663034873669,0.00832232784878872,"up","yes","GABRR2","protein_coding","chr6:89257208-89315299:-","gi|767942552|ref|XP_011534015.1|",1826,0,"PREDICTED: gamma-aminobutyric acid receptor subunit rho-2 isoform X1 [Homo sapiens]","gi|767942555|ref|XM_011535715.1|",1691,0,"PREDICTED: Homo sapiens gamma-aminobutyric acid (GABA) A receptor, rho 2 (GABRR2), transcript variant X3, mRNA","P28476",707,0,"Gamma-aminobutyric acid receptor subunit rho-2",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007268|synaptic transmission;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0007165|signal transduction;GO:0007601|visual perception;","GO:0030054|cell junction;GO:0034707|chloride channel complex;GO:1902711|GABA-A receptor complex;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;","GO:0005254|chloride channel activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0004890|GABA-A receptor activity;GO:0019904|protein domain specific binding;","K05190","GABRR; gamma-aminobutyric acid receptor subunit rho"]
["ENSG00000257732",27,35,29,24.1870051077805,9,13,33,2.05298063106323,1.03772001634041,0.0156817298977171,0.0398405171584783,"up","yes","AC089983.1","antisense","chr12:104262314-104280722:-",".",".",".",".","gi|551875140|tpe|HG505133.1|",701,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000407792.1 (RP11-818F20.5 gene), antisense",".",".",".",".",".",".",".",".","pfam04018","DUF368","Domain of unknown function (DUF368). Predicted transmembrane domain of unknown function. Family members have between 6 and 9 predicted transmembrane segments.",".",".",".",".","."]
["ENSG00000239467",186,133,164,128.752811271548,69,98,114,2.05095027877,1.03629251695602,1.30634464508488e-08,7.64233409596516e-08,"up","yes","AC007405.3","lincRNA","chr2:170771113-170778148:+","gi|586597905|ref|NP_001276960.1|",345,1e-36,"glutamate-rich protein 2 isoform 3 [Homo sapiens]","gi|551847603|tpe|HG494865.1|",660,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000333724.1 (AC007405.6 gene), lincRNA",".",".",".",".",".",".",".",".","pfam05090","VKG_Carbox","Vitamin K-dependent gamma-carboxylase. Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase.",".",".",".",".","."]
["ENSG00000198380",5993,5375,5209,4425.6342079842,2599,3216,3788,2.05032365432769,1.03585166467587,5.42045269186554e-172,7.74442159412612e-170,"up","yes","GFPT1","protein_coding","chr2:69319769-69387254:-","gi|347659028|ref|NP_001231639.1|",3686,0,"glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform 1 [Homo sapiens]","gi|347659027|ref|NM_001244710.1|",8703,0,"Homo sapiens glutamine--fructose-6-phosphate transaminase 1 (GFPT1), transcript variant 1, mRNA","Q06210",1424,0,"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1","YKL104c",768,0,"COG0449","pfam00310","GATase_2","Glutamine amidotransferases class-II.","GO:0032922|circadian regulation of gene expression;GO:0006112|energy reserve metabolic process;GO:0006002|fructose 6-phosphate metabolic process;GO:0006541|glutamine metabolic process;GO:0036498|IRE1-mediated unfolded protein response;GO:0006487|protein N-linked glycosylation;GO:0006048|UDP-N-acetylglucosamine biosynthetic process;GO:0006047|UDP-N-acetylglucosamine metabolic process;","GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0097367|carbohydrate derivative binding;GO:0004360|glutamine-fructose-6-phosphate transaminase (isomerizing) activity;","K00820","glmS, GFPT; glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]"]
["ENSG00000229589",38,32,25,25.1487069428666,13,14,29,2.04732391512241,1.03373937484364,0.00999012363948702,0.0265449104227064,"up","yes","ACVR2B-AS1","antisense","chr3:38451027-38454820:-","gi|694919214|ref|XP_009450650.1|",163,1e-20,"PREDICTED: protein GVQW1-like [Pan troglodytes]","gi|257195171|ref|NR_028389.1|",2517,0,"Homo sapiens ACVR2B antisense RNA 1 (ACVR2B-AS1), long non-coding RNA","Q6B4Z3",53.9,4e-17,"Histone demethylase UTY",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0010468|regulation of gene expression;","GO:0005634|nucleus;","GO:0051213|dioxygenase activity;GO:0071558|histone demethylase activity (H3-K27 specific);GO:0046872|metal ion binding;","K11447","UTX, UTY; histone demethylase [EC:1.14.11.-]"]
["ENSG00000078114",95,56,104,68.159226438111,35,43,73,2.04694475051568,1.03347216282408,0.000167244901974921,0.000618802929079661,"up","yes","NEBL","protein_coding","chr10:20779973-21174187:-","gi|5453758|ref|NP_006384.1|",5191,0,"nebulette isoform 1 [Homo sapiens]","gi|197313771|ref|NM_006393.2|",9216,0,"Homo sapiens nebulette (NEBL), transcript variant 1, mRNA","O76041",2002,0,"Nebulette",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0071691|cardiac muscle thin filament assembly;","GO:0070062|extracellular exosome;GO:0031674|I band;GO:0001725|stress fiber;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0008092|cytoskeletal protein binding;GO:0031005|filamin binding;GO:0008307|structural constituent of muscle;GO:0005523|tropomyosin binding;",".","."]
["ENSG00000164061",68,42,46,41.3588888000622,18,38,35,2.04464241907453,1.03184855693936,0.00140623324297851,0.00447581300174413,"up","yes","BSN","protein_coding","chr3:49554489-49671545:+","gi|3982598|gb|AAC83555.1|",9194,0,"neuronal double zinc finger protein [Homo sapiens]","gi|150456461|ref|NM_003458.3|",15955,0,"Homo sapiens bassoon presynaptic cytomatrix protein (BSN), mRNA","Q9UPA5",3546,0,"Protein bassoon",".",".",".",".","pfam05715","zf-piccolo","Piccolo Zn-finger. This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.","GO:0007268|synaptic transmission;GO:0035418|protein localization to synapse;GO:0007416|synapse assembly;","GO:0030424|axon;GO:0030054|cell junction;GO:0009986|cell surface;GO:0048788|cytoskeleton of presynaptic active zone;GO:0030425|dendrite;GO:0060076|excitatory synapse;GO:0044306|neuron projection terminus;GO:0005634|nucleus;GO:0014069|postsynaptic density;GO:0048786|presynaptic active zone;","GO:0046872|metal ion binding;",".","."]
["ENSG00000167106",1223,1164,1071,924.7519785857,563,637,811,2.04325173670978,1.03086696076685,4.22268236243913e-51,1.25303226779578e-49,"up","yes","FAM102A","protein_coding","chr9:127940579-127980513:-","gi|18676564|dbj|BAB84934.1|",714,7e-83,"FLJ00179 protein [Homo sapiens]","gi|18676563|dbj|AK074108.1|",4284,0,"Homo sapiens mRNA for FLJ00179 protein",".",".",".",".",".",".",".",".","pfam09867","DUF2094","Uncharacterized protein conserved in bacteria (DUF2094). This domain, found in various hypothetical prokaryotic proteins, has no known function.",".",".",".",".","."]
["ENSG00000223559",53,44,48,38.8156070471116,22,33,29,2.04277716958879,1.03053184045772,0.00118546014543662,0.0038204102397964,"up","yes","AC073136.1","processed_pseudogene","chr7:56288230-56291425:+","gi|8051636|ref|NP_009166.2|",3237,0,"exportin-T [Homo sapiens]","gi|694921183|ref|XR_022575.4|",2755,0,"PREDICTED: Pan troglodytes exportin-T-like (LOC750680), misc_RNA","O43592",1251,0,"Exportin-T",".",".",".",".","pfam08389","Xpo1","Exportin 1-like protein. The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.","GO:0006409|tRNA export from nucleus;GO:0071528|tRNA re-export from nucleus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;","GO:0008536|Ran GTPase binding;GO:0000049|tRNA binding;","K14288","XPOT; exportin-T"]
["ENSG00000248932",45,37,34,30.8625788090371,17,20,31,2.0421431673326,1.03008401193583,0.00355428124214034,0.0104409041423093,"up","yes","AC097103.2","antisense","chr3:139389815-139583319:+",".",".",".",".","gi|551850847|tpe|HG496093.1|",602,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000358486.1 (RP11-319G6.1 gene), antisense",".",".",".",".",".",".",".",".","pfam14543","TAXi_N","Xylanase inhibitor N-terminal. The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylanase.  Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.",".",".",".",".","."]
["ENSG00000247498",52,36,32,32.0394798844418,27,17,24,2.04210053400283,1.03005389282544,0.00528754626517146,0.0149627629640005,"up","yes","GPRC5D-AS1","antisense","chr12:12927726-12984645:+","gi|119616698|gb|EAW96292.1|",487,2e-55,"hCG1774691, isoform CRA_b, partial [Homo sapiens]","gi|551872532|tpe|HG504538.1|",1746,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000400749.3 (RP11-392P7.6 gene), antisense",".",".",".",".",".",".",".",".","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.",".",".",".",".","."]
["ENSG00000111671",395,374,355,300.467424930927,178,183,299,2.03944535969663,1.02817685532819,7.34745334346409e-17,7.51817931505227e-16,"up","yes","SPSB2","protein_coding","chr12:6870935-6889358:-","gi|530398914|ref|XP_005253860.1|",1303,5e-176,"PREDICTED: SPRY domain-containing SOCS box protein 2 isoform X2 [Homo sapiens]","gi|767971505|ref|XM_005253803.3|",1496,0,"PREDICTED: Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant X1, mRNA","Q99619",440,1e-151,"SPRY domain-containing SOCS box protein 2",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0035556|intracellular signal transduction;GO:0043687|post-translational protein modification;GO:0016567|protein ubiquitination;","GO:0005829|cytosol;",".","K10344","SPSB2, SSB2; SPRY domain-containing SOCS box protein 2"]
["ENSG00000160323",32,43,51,33.9692006102014,10,40,25,2.03875618235003,1.02768925179048,0.0095895532522094,0.0255650729963531,"up","yes","ADAMTS13","protein_coding","chr9:133414358-133459402:+","gi|21265034|ref|NP_620594.1|",7366,0,"A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein [Homo sapiens]","gi|525313719|ref|NM_139025.4|",4934,0,"Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13), transcript variant 1, mRNA","Q76LX8",2841,0,"A disintegrin and metalloproteinase with thrombospondin motifs 13",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0007160|cell-matrix adhesion;GO:0071346|cellular response to interferon-gamma;GO:0071353|cellular response to interleukin-4;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0009100|glycoprotein metabolic process;GO:0007229|integrin-mediated signaling pathway;GO:0043171|peptide catabolic process;GO:0030168|platelet activation;GO:0016485|protein processing;GO:0006508|proteolysis;GO:0014075|response to amine;GO:0035864|response to potassium ion;GO:0009636|response to toxic substance;","GO:0009986|cell surface;GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005615|extracellular space;","GO:0005509|calcium ion binding;GO:0005178|integrin binding;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08627","ADAMTS13; a disintegrin and metalloproteinase with thrombospondin motifs 13 [EC:3.4.24.87]"]
["ENSG00000120129",2866,2921,2614,2249.25835439776,1296,1589,2038,2.03667371857073,1.02621487460734,1.45708558771145e-93,8.78258337993077e-92,"up","yes","DUSP1","protein_coding","chr5:172768090-172771195:-","gi|4758204|ref|NP_004408.1|",1861,0,"dual specificity protein phosphatase 1 [Homo sapiens]","gi|259013538|ref|NM_004417.3|",2019,0,"Homo sapiens dual specificity phosphatase 1 (DUSP1), mRNA","P28562",721,0,"Dual specificity protein phosphatase 1","SPBC17A3.06",74.7,1e-13,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0032870|cellular response to hormone stimulus;GO:0001706|endoderm formation;GO:0000188|inactivation of MAPK activity;GO:0035556|intracellular signal transduction;GO:0071850|mitotic cell cycle arrest;GO:0043066|negative regulation of apoptotic process;GO:0008285|negative regulation of cell proliferation;GO:2000279|negative regulation of DNA biosynthetic process;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0043407|negative regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0051447|negative regulation of meiotic cell cycle;GO:0070262|peptidyl-serine dephosphorylation;GO:0035970|peptidyl-threonine dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043065|positive regulation of apoptotic process;GO:0042981|regulation of apoptotic process;GO:0090266|regulation of mitotic cell cycle spindle assembly checkpoint;GO:0051592|response to calcium ion;GO:0051591|response to cAMP;GO:0032355|response to estradiol;GO:0051384|response to glucocorticoid;GO:0042542|response to hydrogen peroxide;GO:0009416|response to light stimulus;GO:0032526|response to retinoic acid;GO:0033574|response to testosterone;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0019838|growth factor binding;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0051019|mitogen-activated protein kinase binding;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;",".","."]
["ENSG00000105639",52,28,53,35.6344593557679,21,24,33,2.03617153891325,1.02585910754066,0.00344962227974309,0.010164423240404,"up","yes","JAK3","protein_coding","chr19:17824780-17848071:-","gi|530414824|ref|XP_005259953.1|",5889,0,"PREDICTED: tyrosine-protein kinase JAK3 isoform X2 [Homo sapiens]","gi|768002298|ref|XM_005259896.2|",5432,0,"PREDICTED: Homo sapiens Janus kinase 3 (JAK3), transcript variant X1, mRNA","P52333",2204,0,"Tyrosine-protein kinase JAK3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0030183|B cell differentiation;GO:0016477|cell migration;GO:0019221|cytokine-mediated signaling pathway;GO:0007167|enzyme linked receptor protein signaling pathway;GO:0030218|erythrocyte differentiation;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0035723|interleukin-15-mediated signaling pathway;GO:0038110|interleukin-2-mediated signaling pathway;GO:0038114|interleukin-21-mediated signaling pathway;GO:0035771|interleukin-4-mediated signaling pathway;GO:0038111|interleukin-7-mediated signaling pathway;GO:0038113|interleukin-9-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0060397|JAK-STAT cascade involved in growth hormone signaling pathway;GO:0000165|MAPK cascade;GO:0002731|negative regulation of dendritic cell cytokine production;GO:0045221|negative regulation of FasL biosynthetic process;GO:0032693|negative regulation of interleukin-10 production;GO:0032695|negative regulation of interleukin-12 production;GO:0050868|negative regulation of T cell activation;GO:0045626|negative regulation of T-helper 1 cell differentiation;GO:0070244|negative regulation of thymocyte apoptotic process;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0042102|positive regulation of T cell proliferation;GO:0006468|protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0046425|regulation of JAK-STAT cascade;GO:0070232|regulation of T cell apoptotic process;GO:0070672|response to interleukin-15;GO:0070669|response to interleukin-2;GO:0070670|response to interleukin-4;GO:0071104|response to interleukin-9;GO:0043029|T cell homeostasis;GO:0007260|tyrosine phosphorylation of STAT protein;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005768|endosome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0005524|ATP binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0019903|protein phosphatase binding;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0005102|receptor binding;","K11218","JAK3; Janus kinase 3 [EC:2.7.10.2]"]
["ENSG00000106733",97,93,87,74.1456419926857,41,58,63,2.0359176468312,1.02567920536688,6.50019244865351e-06,2.89752049802702e-05,"up","yes","NMRK1","protein_coding","chr9:75060573-75088217:-","gi|578817603|ref|XP_006717225.1|",1101,9e-144,"PREDICTED: nicotinamide riboside kinase 1 isoform X2 [Homo sapiens]","gi|21756814|dbj|AK097144.1|",2006,0,"Homo sapiens cDNA FLJ39825 fis, clone SPLEN2012175, highly similar to Nicotinamide riboside kinase 1 (EC 2.7.1.-)","Q9NWW6",400,4e-134,"Nicotinamide riboside kinase 1","SPBP22H7.06",58.9,6e-09,"COG0572","pfam13238","AAA_18","AAA domain.","GO:0009435|NAD biosynthetic process;GO:0019674|NAD metabolic process;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0050262|ribosylnicotinamide kinase activity;","K10524","NRK1_2; nicotinamide/nicotinate riboside kinase [EC:2.7.1.22 2.7.1.173]"]
["ENSG00000137474",189,154,164,135.866661365137,86,97,112,2.03311902195425,1.02369467526966,2.36574357442941e-09,1.48054711432818e-08,"up","yes","MYO7A","protein_coding","chr11:77128264-77215241:+","gi|189083798|ref|NP_000251.3|",11369,0,"unconventional myosin-VIIa isoform 1 [Homo sapiens]","gi|189083797|ref|NM_000260.3|",7465,0,"Homo sapiens myosin VIIA (MYO7A), transcript variant 1, mRNA","Q13402",4374,0,"Unconventional myosin-VIIa","SPCC1919.10c",533,3e-157,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0030048|actin filament-based movement;GO:0060088|auditory receptor cell stereocilium organization;GO:0050957|equilibrioception;GO:0042462|eye photoreceptor cell development;GO:0006886|intracellular protein transport;GO:0007040|lysosome organization;GO:0007018|microtubule-based movement;GO:0001845|phagolysosome assembly;GO:0051904|pigment granule transport;GO:0048563|post-embryonic organ morphogenesis;GO:0050953|sensory perception of light stimulus;GO:0007605|sensory perception of sound;GO:0007601|visual perception;","GO:0016324|apical plasma membrane;GO:0005938|cell cortex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005765|lysosomal membrane;GO:0042470|melanosome;GO:0005902|microvillus;GO:0031477|myosin VII complex;GO:0032391|photoreceptor connecting cilium;GO:0001917|photoreceptor inner segment;GO:0001750|photoreceptor outer segment;GO:0032420|stereocilium;GO:0045202|synapse;GO:1990435|upper tip-link density;","GO:0051015|actin filament binding;GO:0030898|actin-dependent ATPase activity;GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0000146|microfilament motor activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0047485|protein N-terminus binding;GO:0030507|spectrin binding;","K10359","MYO7; myosin VII"]
["ENSG00000215267",314,290,282,237.344549587439,139,171,209,2.03210485291088,1.02297484446827,1.07590729143375e-15,1.03295668676825e-14,"up","yes","AKR1C7P","transcribed_unprocessed_pseudogene","chr10:5275173-5288470:-","gi|114629255|ref|XP_001154113.1|",1119,1e-150,"PREDICTED: estradiol 17 beta-dehydrogenase 5-like [Pan troglodytes]","gi|114629254|ref|XM_001154113.1|",828,0,"PREDICTED: Pan troglodytes estradiol 17 beta-dehydrogenase 5-like (LOC746545), mRNA","P42330",350,2e-118,"Aldo-keto reductase family 1 member C3","YHR104w",154,9e-43,"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0071276|cellular response to cadmium ion;GO:0071277|cellular response to calcium ion;GO:0071384|cellular response to corticosteroid stimulus;GO:0071395|cellular response to jasmonic acid stimulus;GO:0071799|cellular response to prostaglandin D stimulus;GO:0071379|cellular response to prostaglandin stimulus;GO:0034614|cellular response to reactive oxygen species;GO:0009267|cellular response to starvation;GO:0019371|cyclooxygenase pathway;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0016488|farnesol catabolic process;GO:0007186|G-protein coupled receptor signaling pathway;GO:0030216|keratinocyte differentiation;GO:0043170|macromolecule metabolic process;GO:0008584|male gonad development;GO:1900053|negative regulation of retinoic acid biosynthetic process;GO:0055114|oxidation-reduction process;GO:0010942|positive regulation of cell death;GO:0008284|positive regulation of cell proliferation;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:0051897|positive regulation of protein kinase B signaling;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:0042448|progesterone metabolic process;GO:0006693|prostaglandin metabolic process;GO:0000060|protein import into nucleus, translocation;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:2000224|regulation of testosterone biosynthetic process;GO:0070293|renal absorption;GO:0007584|response to nutrient;GO:0042574|retinal metabolic process;GO:0001523|retinoid metabolic process;GO:0008202|steroid metabolic process;GO:0061370|testosterone biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005622|intracellular;GO:0005634|nucleus;","GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0004033|aldo-keto reductase (NADP) activity;GO:0047023|androsterone dehydrogenase activity;GO:0047787|delta4-3-oxosteroid 5beta-reductase activity;GO:0035410|dihydrotestosterone 17-beta-dehydrogenase activity;GO:0045550|geranylgeranyl reductase activity;GO:0047718|indanol dehydrogenase activity;GO:0045703|ketoreductase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0052650|NADP-retinol dehydrogenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0036131|prostaglandin D2 11-ketoreductase activity;GO:0036130|prostaglandin H2 endoperoxidase reductase activity;GO:0047017|prostaglandin-F synthase activity;GO:0001758|retinal dehydrogenase activity;GO:0004745|retinol dehydrogenase activity;GO:0047045|testosterone 17-beta-dehydrogenase (NADP+) activity;GO:0047035|testosterone dehydrogenase (NAD+) activity;GO:0047115|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;","K04119","AKR1C3; aldo-keto reductase family 1 member C3 [EC:1.1.1.64 1.1.1.188 1.1.1.213]"]
["ENSG00000225756",68,41,53,43.2049693441242,22,36,37,2.0300100450704,1.02148686629587,0.000984278762975941,0.00322760434890853,"up","yes","DBH-AS1","antisense","chr9:133654586-133657313:-","gi|119608506|gb|EAW88100.1|",590,7e-69,"hCG2033147 [Homo sapiens]","gi|551867807|tpe|HG502510.1|",2139,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000054928.1 (NCRNA00118 gene), antisense","P09172",75.9,7e-13,"Dopamine beta-hydroxylase",".",".",".",".","pfam15360","Apelin","APJ endogenous ligand. Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes. It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis.","GO:0048149|behavioral response to ethanol;GO:0001974|blood vessel remodeling;GO:0042423|catecholamine biosynthetic process;GO:0007268|synaptic transmission;GO:0001816|cytokine production;GO:0042420|dopamine catabolic process;GO:0042596|fear response;GO:0042593|glucose homeostasis;GO:0042309|homoiothermy;GO:0002443|leukocyte mediated immunity;GO:0050900|leukocyte migration;GO:0007626|locomotory behavior;GO:0042711|maternal behavior;GO:0007613|memory;GO:0042421|norepinephrine biosynthetic process;GO:0006589|octopamine biosynthetic process;GO:0045907|positive regulation of vasoconstriction;GO:0042127|regulation of cell proliferation;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:0001975|response to amphetamine;GO:0048265|response to pain;GO:0008542|visual learning;","GO:0034466|chromaffin granule lumen;GO:0042584|chromaffin granule membrane;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005815|microtubule organizing center;GO:0034774|secretory granule lumen;GO:0030667|secretory granule membrane;GO:0030658|transport vesicle membrane;","GO:0003824|catalytic activity;GO:0005507|copper ion binding;GO:0004500|dopamine beta-monooxygenase activity;GO:0031418|L-ascorbic acid binding;","K00503","DBH; dopamine beta-monooxygenase [EC:1.14.17.1]"]
["ENSG00000259129",38,37,36,29.7929452572679,16,26,23,2.02847065195255,1.02039242968799,0.00462931977103341,0.0132793455894843,"up","yes","LINC00648","lincRNA","chr14:47764954-47795092:-","gi|332843270|ref|XP_003314600.1|",235,3e-19,"PREDICTED: uncharacterized protein LOC100611144 isoform X2 [Pan troglodytes]","gi|551877759|tpe|HG506165.1|",2885,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000410573.1 (RP11-479H16.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam02118","Srg","Srg family chemoreceptor.",".",".",".",".","."]
["ENSG00000204947",170,147,142,123.074663579124,76,92,100,2.0259743365629,1.01861589933751,1.12007018050951e-08,6.59862970118125e-08,"up","yes","ZNF425","protein_coding","chr7:149102784-149126346:-","gi|119600467|gb|EAW80061.1|",4230,0,"zinc finger protein 425 [Homo sapiens]","gi|296531446|ref|NM_001001661.2|",3220,0,"Homo sapiens zinc finger protein 425 (ZNF425), mRNA","Q6IV72",1534,0,"Zinc finger protein 425","SPAC144.09c",112,2e-25,"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000140941",3256,2904,3005,2458.36373375683,1422,1801,2167,2.02562283330202,1.01836557237195,4.29193578472714e-104,2.96712750594326e-102,"up","yes","MAP1LC3B","protein_coding","chr16:87383995-87404779:+","gi|795345911|ref|XP_011783418.1|",483,1e-60,"PREDICTED: microtubule-associated proteins 1A/1B light chain 3B [Colobus angolensis palliatus]","gi|28374393|gb|BC045759.1|",2608,0,"Homo sapiens microtubule-associated protein 1 light chain 3 beta, mRNA (cDNA clone MGC:48651 IMAGE:4828857), complete cds","Q9GZQ8",192,7e-55,"Microtubule-associated proteins 1A/1B light chain 3B",".",".",".",".","pfam02991","Atg8","Autophagy protein Atg8 ubiquitin like. Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity. Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. The yeast proteins are involved in the autophagosome, and Atg8 binds Atg19, via its N-terminus and the C-terminus of Atg19.","GO:0000045|autophagosome assembly;GO:0097352|autophagosome maturation;GO:0006914|autophagy;GO:0000422|mitophagy;GO:0006995|cellular response to nitrogen starvation;GO:0009267|cellular response to starvation;GO:0016236|macroautophagy;","GO:0005776|autophagosome;GO:0000421|autophagosome membrane;GO:0005930|axoneme;GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0005622|intracellular;GO:0005874|microtubule;GO:0005739|mitochondrion;GO:0031090|organelle membrane;","GO:0031625|ubiquitin protein ligase binding;","K10435","MAP1LC; microtubule-associated protein 1 light chain"]
["ENSG00000163491",70,66,61,52.8725493274836,30,46,39,2.02550566122995,1.01828211732105,0.000204343199673772,0.000745483570135751,"up","yes","NEK10","protein_coding","chr3:27110085-27369460:-","gi|207029296|ref|NP_689747.3|",5717,0,"serine/threonine-protein kinase Nek10 isoform 2 [Homo sapiens]","gi|749385077|ref|NM_152534.4|",3926,0,"Homo sapiens NIMA related kinase 10 (NEK10), transcript variant 2, mRNA","Q6ZWH5",2202,0,"Serine/threonine-protein kinase Nek10",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0043406|positive regulation of MAP kinase activity;GO:0031954|positive regulation of protein autophosphorylation;GO:0006468|protein phosphorylation;GO:1902749|regulation of cell cycle G2/M phase transition;GO:0070372|regulation of ERK1 and ERK2 cascade;","GO:1902911|protein kinase complex;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;",".","."]
["ENSG00000116991",257,224,224,188.669210565052,95,146,177,2.02173796352603,1.01559602235509,5.76825043878165e-12,4.44676316799442e-11,"up","yes","SIPA1L2","protein_coding","chr1:232397965-232561558:-","gi|112421013|ref|NP_065859.3|",8171,0,"signal-induced proliferation-associated 1-like protein 2 [Homo sapiens]","gi|530366371|ref|XM_005273214.1|",6680,0,"PREDICTED: Homo sapiens signal-induced proliferation-associated 1 like 2 (SIPA1L2), transcript variant X8, mRNA","Q9P2F8",3152,0,"Signal-induced proliferation-associated 1-like protein 2",".",".",".",".","pfam02145","Rap_GAP","Rap/ran-GAP.","GO:0051056|regulation of small GTPase mediated signal transduction;",".","GO:0005096|GTPase activator activity;","K17702","SIPA1L2, SPAL2; signal-induced proliferation-associated 1 like protein 2"]
["ENSG00000153132",658,559,573,480.505598332643,281,379,391,2.01858258678031,1.0133426133733,1.56210828161683e-25,2.35390191686136e-24,"up","yes","CLGN","protein_coding","chr4:140388455-140427968:-","gi|158255074|dbj|BAF83508.1|",2764,0,"unnamed protein product [Homo sapiens]","gi|194578886|ref|NM_004362.2|",2736,0,"Homo sapiens calmegin (CLGN), transcript variant 1, mRNA","O14967",1061,0,"Calmegin",".",".",".",".","pfam00262","Calreticulin","Calreticulin family.","GO:0007339|binding of sperm to zona pellucida;GO:0065003|macromolecular complex assembly;GO:0007338|single fertilization;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005635|nuclear envelope;","GO:0005509|calcium ion binding;GO:0044183|protein binding involved in protein folding;GO:0051082|unfolded protein binding;","K09551","CLGN; calmegin"]
["ENSG00000273142",92,80,62,62.5923186551213,35,54,48,2.01639336142247,1.0117771096788,8.39171543724368e-05,0.000323137167805063,"up","yes","AC073335.2","lincRNA","chr7:66902857-66906297:+","gi|221043496|dbj|BAH13425.1|",911,5e-111,"unnamed protein product [Homo sapiens]","gi|551861942|tpe|HG500317.1|",3441,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000472525.1 (RP11-458F8.4 gene), lincRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSG00000008323",34,25,46,28.3302852273853,11,28,24,2.01522317385537,1.01093961740611,0.0117435885142283,0.0307758607693527,"up","yes","PLEKHG6","protein_coding","chr12:6310436-6328506:+","gi|222080070|ref|NP_001138329.1|",3587,0,"pleckstrin homology domain-containing family G member 6 isoform b [Homo sapiens]","gi|222080069|ref|NM_001144857.1|",3111,0,"Homo sapiens pleckstrin homology and RhoGEF domain containing G6 (PLEKHG6), transcript variant 3, mRNA","Q3KR16",1357,0,"Pleckstrin homology domain-containing family G member 6","SPCC645.07",74.3,2e-12,"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0035023|regulation of Rho protein signal transduction;","GO:0030054|cell junction;GO:0005813|centrosome;GO:0032154|cleavage furrow;GO:0005737|cytoplasm;GO:0005902|microvillus;GO:0000922|spindle pole;","GO:0005096|GTPase activator activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["ENSG00000275882",29,28,25,21.9472883907031,9,20,20,2.01289980078473,1.00927535879238,0.0167954408095788,0.0422691104299526,"up","yes","IKBKGP1","unprocessed_pseudogene","chrX:154639978-154648275:-","gi|223671870|ref|NP_001093326.2|",1353,0,"NF-kappa-B essential modulator isoform b [Homo sapiens]","gi|768040284|ref|XM_011531205.1|",1073,0,"PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X5, mRNA","Q9Y6K9",525,0,"NF-kappa-B essential modulator",".",".",".",".","pfam11577","NEMO","NF-kappa-B essential modulator NEMO. NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK.","GO:0000187|activation of MAPK activity;GO:0043276|anoikis;GO:0002479|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0051650|establishment of vesicle localization;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0007254|JNK cascade;GO:0002756|MyD88-independent toll-like receptor signaling pathway;GO:1901215|negative regulation of neuron death;GO:0070423|nucleotide-binding oligomerization domain containing signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016239|positive regulation of macroautophagy;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016579|protein deubiquitination;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0009615|response to virus;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0051403|stress-activated MAPK cascade;GO:0050852|T cell receptor signaling pathway;GO:0006351|transcription, DNA-templated;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0016032|viral process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0008385|IkappaB kinase complex;GO:0005622|intracellular;GO:0072686|mitotic spindle;GO:0005634|nucleus;GO:0000922|spindle pole;GO:0000151|ubiquitin ligase complex;","GO:0042802|identical protein binding;GO:0070530|K63-linked polyubiquitin binding;GO:1990450|linear polyubiquitin binding;GO:0046872|metal ion binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0031625|ubiquitin protein ligase binding;","K07210","IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma"]
["ENSG00000166783",1796,1664,1579,1353.62753899373,783,971,1235,2.01027246732957,1.00739105395393,1.75383459259416e-70,7.33795262949156e-69,"up","yes","MARF1","protein_coding","chr16:15594386-15643166:-","gi|85797660|ref|NP_055462.2|",8657,0,"meiosis arrest female protein 1 isoform 1 [Homo sapiens]","gi|297206750|ref|NM_014647.3|",7743,0,"Homo sapiens KIAA0430 (KIAA0430), transcript variant 1, mRNA","Q9Y4F3",3278,0,"Meiosis regulator and mRNA stability factor 1",".",".",".",".","pfam11608","Limkain-b1","Limkain b1. This family of proteins represents Limkain b1, which is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures.","GO:0006302|double-strand break repair;GO:0007143|female meiotic division;GO:0010923|negative regulation of phosphatase activity;GO:0048477|oogenesis;GO:0010468|regulation of gene expression;","GO:0005794|Golgi apparatus;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005777|peroxisome;","GO:0003723|RNA binding;","K17573","LKAP, MARF1; meiosis arrest female protein 1"]
["ENSG00000109929",1383,1234,1166,1016.40683006983,608,746,882,2.00900025088134,1.0064777442331,1.46732787209087e-53,4.56480967691754e-52,"up","yes","SC5D","protein_coding","chr11:121292453-121308694:+","gi|68160941|ref|NP_008849.2|",1584,0,"lathosterol oxidase [Homo sapiens]","gi|694947528|ref|XM_001167285.2|",2295,0,"PREDICTED: Pan troglodytes sterol-C5-desaturase (SC5D), transcript variant X1, mRNA","O75845",614,0,"Lathosterol oxidase","SPAC1687.16c",259,2e-78,"COG3000","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.","GO:0033489|cholesterol biosynthetic process via desmosterol;GO:0033490|cholesterol biosynthetic process via lathosterol;GO:0006629|lipid metabolic process;GO:0045540|regulation of cholesterol biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0000248|C-5 sterol desaturase activity;GO:0005506|iron ion binding;GO:0050046|lathosterol oxidase activity;","K00227","SC5DL, ERG3; delta7-sterol 5-desaturase [EC:1.14.19.20]"]
["ENSG00000183960",35,37,29,27.2504889663699,21,16,22,2.00812440796707,1.00584865036306,0.00839197860949232,0.0226987075332896,"up","yes","KCNH8","protein_coding","chr3:19148454-19535646:+","gi|27886667|ref|NP_653234.2|",5638,0,"potassium voltage-gated channel subfamily H member 8 [Homo sapiens]","gi|27886666|ref|NM_144633.2|",5063,0,"Homo sapiens potassium voltage-gated channel subfamily H member 8 (KCNH8), mRNA","Q96L42",2171,0,"Potassium voltage-gated channel subfamily H member 8","CC0285_1",86.7,3e-17,"COG2202","pfam13426","PAS_9","PAS domain.","GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;","GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0000155|phosphorelay sensor kinase activity;GO:0005249|voltage-gated potassium channel activity;","K04911","KCNH8; potassium voltage-gated channel Eag-related subfamily H member 8"]
["ENSG00000038002",458,445,381,345.24279351512,213,251,294,2.00789884164217,1.00568658784577,3.24966243988963e-20,3.92482712214096e-19,"up","yes","AGA","protein_coding","chr4:177430770-177442503:-","gi|114596999|ref|XP_517545.2|",1736,0,"PREDICTED: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [Pan troglodytes]","gi|285002250|ref|NM_000027.3|",2103,0,"Homo sapiens aspartylglucosaminidase (AGA), transcript variant 1, mRNA","P20933",653,0,"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase","CC2359",150,3e-39,"COG1446","pfam01112","Asparaginase_2","Asparaginase.","GO:0043312|neutrophil degranulation;GO:0006517|protein deglycosylation;GO:0051604|protein maturation;","GO:0035578|azurophil granule lumen;GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0003948|N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity;GO:0008233|peptidase activity;GO:0043621|protein self-association;","K01444","AGA, aspG; N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26]"]
["ENSG00000123329",39,39,27,28.0531699893875,12,24,27,2.00334233171328,1.00240897035955,0.00798377764336804,0.021685219244489,"up","yes","ARHGAP9","protein_coding","chr12:57472255-57488814:-","gi|985690090|ref|NP_001306779.1|",3833,0,"rho GTPase-activating protein 9 isoform 4 [Homo sapiens]","gi|985690089|ref|NM_001319850.1|",2912,0,"Homo sapiens Rho GTPase activating protein 9 (ARHGAP9), transcript variant 4, mRNA","Q9BRR9",1337,0,"Rho GTPase-activating protein 9",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0043312|neutrophil degranulation;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0034774|secretory granule lumen;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;",".","."]
["ENSG00000146733",1517,1541,1509,1230.6772683796,660,955,1117,2.00295627880543,1.00213092986804,2.41396023483703e-48,6.7576872292506e-47,"up","yes","PSPH","protein_coding","chr7:56011051-56051604:-","gi|119628375|gb|EAX07970.1|",1188,2e-155,"phosphoserine phosphatase, isoform CRA_b [Homo sapiens]","gi|530385297|ref|XM_005271773.1|",2171,0,"PREDICTED: Homo sapiens phosphoserine phosphatase (PSPH), transcript variant X1, mRNA","Q5RB83",451,4e-153,"Phosphoserine phosphatase","PA4960_2",92.8,5e-20,"COG0560","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006564|L-serine biosynthetic process;GO:0006563|L-serine metabolic process;",".","GO:0005509|calcium ion binding;GO:0000287|magnesium ion binding;GO:0004647|phosphoserine phosphatase activity;",".","."]
["ENSG00000268218",85,50,73,55.5709184684679,19,46,62,2.00259410978403,1.00187004214882,0.000900731498316596,0.00297386325565397,"up","yes","AC137932.3","antisense","chr16:89268104-89273044:+","gi|74729985|sp|Q8NAQ8.1|YP023_HUMAN",639,5e-74,"RecName: Full=Putative uncharacterized protein FLJ34945","gi|666672203|tpe|LK938268.1|",3660,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000430483.2 (AC137932.4 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000214655",1681,1575,1521,1287.0959220666,790,912,1136,2.00049217136667,1.00035498291867,3.97257539130835e-65,1.49654363569444e-63,"up","yes","ZSWIM8","protein_coding","chr10:73785582-73801797:+","gi|530393326|ref|XP_005269710.1|",8041,0,"PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X3 [Homo sapiens]","gi|767962246|ref|XM_005269653.2|",6075,0,"PREDICTED: Homo sapiens zinc finger, SWIM-type containing 8 (ZSWIM8), transcript variant X3, mRNA","A7E2V4",3078,0,"Zinc finger SWIM domain-containing protein 8","all4744",67.8,2e-10,"COG4715","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".","GO:0008270|zinc ion binding;",".","."]
["ENSG00000132749",113,111,106,178.098097994254,222,250,312,0.499678836558295,-1.00092697955315,2.38335015165799e-11,1.76672012779321e-10,"down","yes","TESMIN","protein_coding","chr11:68707440-68751564:-","gi|22760513|dbj|BAC11228.1|",1167,2e-147,"unnamed protein product [Homo sapiens]","gi|22760512|dbj|AK074817.1|",3483,0,"Homo sapiens cDNA FLJ90336 fis, clone NT2RP2002409","Q9Y4I5",451,4e-144,"Tesmin",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0030154|cell differentiation;GO:0006875|cellular metal ion homeostasis;GO:0007275|multicellular organismal development;GO:0010038|response to metal ion;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;",".","."]
["ENSG00000134057",2212,2070,2034,3405.67528921081,4079,4892,6078,0.499464199463766,-1.00154682248948,2.48406148215739e-139,2.58986907393793e-137,"down","yes","CCNB1","protein_coding","chr5:69167010-69178245:+","gi|14327896|ref|NP_114172.1|",2092,0,"G2/mitotic-specific cyclin-B1 [Homo sapiens]","gi|356582356|ref|NM_031966.3|",2169,0,"Homo sapiens cyclin B1 (CCNB1), mRNA","P14635",810,0,"G2/mitotic-specific cyclin-B1","SPBC582.03",214,2e-60,"COG5024","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0051301|cell division;GO:0071398|cellular response to fatty acid;GO:0071456|cellular response to hypoxia;GO:0071283|cellular response to iron(III) ion;GO:0071407|cellular response to organic cyclic compound;GO:0048565|digestive tract development;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0000086|G2/M transition of mitotic cell cycle;GO:2000775|histone H3-S10 phosphorylation involved in chromosome condensation;GO:0001701|in utero embryonic development;GO:0007080|mitotic metaphase plate congression;GO:0007077|mitotic nuclear envelope disassembly;GO:0007052|mitotic spindle organization;GO:0010629|negative regulation of gene expression;GO:0001933|negative regulation of protein phosphorylation;GO:0001556|oocyte maturation;GO:0051987|positive regulation of attachment of spindle microtubules to kinetochore;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0048146|positive regulation of fibroblast proliferation;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0033129|positive regulation of histone phosphorylation;GO:0045931|positive regulation of mitotic cell cycle;GO:0031442|positive regulation of mRNA 3'-end processing;GO:0065003|macromolecular complex assembly;GO:0051726|regulation of cell cycle;GO:0060623|regulation of chromosome condensation;GO:0090266|regulation of mitotic cell cycle spindle assembly checkpoint;GO:0046680|response to DDT;GO:0009612|response to mechanical stimulus;GO:0007283|spermatogenesis;GO:0042246|tissue regeneration;GO:0055015|ventricular cardiac muscle cell development;","GO:0005813|centrosome;GO:0000942|condensed nuclear chromosome outer kinetochore;GO:0097125|cyclin B1-CDK1 complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0005759|mitochondrial matrix;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0061575|cyclin-dependent protein serine/threonine kinase activator activity;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0035173|histone kinase activity;GO:0005113|patched binding;GO:0019901|protein kinase binding;GO:0044389|ubiquitin-like protein ligase binding;","K05868","CCNB; cyclin B"]
["ENSG00000160182",20,19,8,25.1518155565779,32,34,45,0.499193558604711,-1.00232877653054,0.0144516359817566,0.0370127678682938,"down","yes","TFF1","protein_coding","chr21:42362282-42366594:-","gi|4507451|ref|NP_003216.1|",441,4e-53,"trefoil factor 1 precursor [Homo sapiens]","gi|694981107|ref|XM_009435660.1|",533,0,"PREDICTED: Pan troglodytes trefoil factor 1 (TFF1), mRNA","P04155",174,1e-54,"Trefoil factor 1",".",".",".",".","pfam00088","Trefoil","Trefoil (P-type) domain.","GO:0005975|carbohydrate metabolic process;GO:0030154|cell differentiation;GO:0007586|digestion;GO:0030277|maintenance of gastrointestinal epithelium;GO:0008285|negative regulation of cell proliferation;GO:0035902|response to immobilization stress;GO:0010039|response to iron ion;GO:0043434|response to peptide hormone;GO:0042060|wound healing;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008083|growth factor activity;",".","."]
["ENSG00000088305",266,258,271,429.498884677665,530,576,793,0.499107717112204,-1.00257688418874,2.00667612969823e-22,2.66012159378828e-21,"down","yes","DNMT3B","protein_coding","chr20:32762385-32809356:+","gi|675729211|ref|XP_008965732.1|",4114,0,"PREDICTED: DNA (cytosine-5)-methyltransferase 3B isoform X1 [Pan paniscus]","gi|28559059|ref|NM_006892.3|",4336,0,"Homo sapiens DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B), transcript variant 1, mRNA","Q9UBC3",1586,0,"DNA (cytosine-5)-methyltransferase 3B",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.","GO:0071549|cellular response to dexamethasone stimulus;GO:0071455|cellular response to hyperoxia;GO:0006306|DNA methylation;GO:0045814|negative regulation of gene expression, epigenetic;GO:0051573|negative regulation of histone H3-K9 methylation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0010628|positive regulation of gene expression;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0045666|positive regulation of neuron differentiation;GO:0014823|response to activity;GO:0031000|response to caffeine;GO:0042220|response to cocaine;GO:0032355|response to estradiol;GO:0001666|response to hypoxia;GO:0010212|response to ionizing radiation;GO:0009636|response to toxic substance;GO:0033189|response to vitamin A;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003886|DNA (cytosine-5-)-methyltransferase activity;GO:0003677|DNA binding;GO:0009008|DNA-methyltransferase activity;GO:0042826|histone deacetylase binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;","K17399","DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]"]
["ENSG00000214182",119,94,88,161.43671699907,165,248,311,0.499009536155939,-1.00286070891716,1.21728071331981e-09,7.8080846020993e-09,"down","yes","PTMAP5","transcribed_processed_pseudogene","chr13:81689911-81691072:+","gi|795575070|ref|XP_011722227.1|",179,1e-19,"PREDICTED: prothymosin alpha-like, partial [Macaca nemestrina]","gi|169646405|ref|NG_004798.3|",1162,0,"Homo sapiens prothymosin, alpha pseudogene 5 (PTMAP5) on chromosome 13",".",".",".",".",".",".",".",".","pfam12698","ABC2_membrane_3","ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.",".",".",".",".","."]
["ENSG00000168685",277,252,201,392.468769308628,457,570,714,0.498985491986581,-1.00293022510296,3.26180012505862e-21,4.09593755287308e-20,"down","yes","IL7R","protein_coding","chr5:35852695-35879603:+","gi|28610151|ref|NP_002176.2|",2365,0,"interleukin-7 receptor subunit alpha precursor [Homo sapiens]","gi|391224479|ref|NM_002185.3|",4600,0,"Homo sapiens interleukin 7 receptor (IL7R), transcript variant 1, mRNA","P16871",912,0,"Interleukin-7 receptor subunit alpha",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0042100|B cell proliferation;GO:0000902|cell morphogenesis;GO:0007166|cell surface receptor signaling pathway;GO:0048872|homeostasis of number of cells;GO:0006955|immune response;GO:0002377|immunoglobulin production;GO:0038111|interleukin-7-mediated signaling pathway;GO:0048535|lymph node development;GO:0061024|membrane organization;GO:0070233|negative regulation of T cell apoptotic process;GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0008361|regulation of cell size;GO:0000018|regulation of DNA recombination;GO:0007165|signal transduction;GO:0030217|T cell differentiation;","GO:0030665|clathrin-coated vesicle membrane;GO:0009897|external side of plasma membrane;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0003823|antigen binding;GO:0004896|cytokine receptor activity;GO:0004917|interleukin-7 receptor activity;","K05072","IL7R; interleukin 7 receptor"]
["ENSG00000134668",135,134,99,197.949427963356,232,280,367,0.498814783841365,-1.00342387058074,7.1214200026605e-12,5.46154866844197e-11,"down","yes","SPOCD1","protein_coding","chr1:31790422-31816051:-","gi|47271475|ref|NP_653170.3|",5597,0,"SPOC domain-containing protein 1 isoform 1 [Homo sapiens]","gi|530354691|ref|NM_144569.5|",3960,0,"Homo sapiens SPOC domain containing 1 (SPOCD1), transcript variant 1, mRNA","Q6ZMY3",2159,0,"SPOC domain-containing protein 1",".",".",".",".","pfam07500","TFIIS_M","Transcription factor S-II (TFIIS), central domain. Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.","GO:0010923|negative regulation of phosphatase activity;GO:0006351|transcription, DNA-templated;",".",".","K17596","SPOCD1; SPOC domain-containing protein 1"]
["ENSG00000261061",68,64,70,109.415889579805,141,153,186,0.498400237516268,-1.00462333899844,1.81341721258555e-07,9.49950874425585e-07,"down","yes","AC092718.4","sense_intronic","chr16:81030770-81031485:+","gi|355563670|gb|EHH20232.1|",264,6e-26,"hypothetical protein EGK_03041, partial [Macaca mulatta]","gi|551882865|tpe|HG508354.1|",716,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000431965.1 (RP11-303E16.2 gene), sense_intronic","Q8WTZ3",91.3,2e-20,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000167523",59,66,67,103.911135833419,122,146,193,0.498335603496659,-1.00481044409862,3.60922361144572e-07,1.83874022761661e-06,"down","yes","SPATA33","protein_coding","chr16:89657802-89671272:+","gi|28279415|gb|AAH45670.1|",475,6e-52,"C16orf55 protein, partial [Homo sapiens]","gi|28279414|gb|BC045670.1|",3318,0,"Homo sapiens chromosome 16 open reading frame 55, mRNA (cDNA clone IMAGE:5298665), partial cds","Q96N06",113,8e-27,"Spermatogenesis-associated protein 33",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;GO:0005634|nucleus;",".",".","."]
["ENSG00000236901",70,84,77,125.001350875215,130,208,218,0.497776851911868,-1.00642895257251,8.70402958646389e-08,4.72378510590083e-07,"down","yes","MIR600HG","sense_intronic","chr9:123109494-123115477:-","gi|12005728|gb|AAG44593.1|AF251293_1",870,1e-103,"GL012 [Homo sapiens]","gi|767957844|ref|XR_929820.1|",5984,0,"PREDICTED: Homo sapiens spermatid perinuclear RNA binding protein (STRBP), transcript variant X7, misc_RNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSG00000167775",771,779,782,1261.32658835634,1463,1771,2377,0.497700229589427,-1.00665104235615,4.62086606483989e-53,1.41471848664495e-51,"down","yes","CD320","protein_coding","chr19:8302127-8308356:-","gi|7706111|ref|NP_057663.1|",667,3e-88,"CD320 antigen isoform 1 precursor [Homo sapiens]","gi|23331160|gb|BC036814.1|",1726,0,"Homo sapiens CD320 molecule, mRNA (cDNA clone IMAGE:5732268), containing frame-shift errors","Q9NPF0",261,8e-90,"CD320 antigen",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0031296|B cell costimulation;GO:0009235|cobalamin metabolic process;GO:0015889|cobalamin transport;GO:0030890|positive regulation of B cell proliferation;GO:0030656|regulation of vitamin metabolic process;","GO:0005783|endoplasmic reticulum;GO:0010008|endosome membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0031419|cobalamin binding;GO:0015420|cobalamin-transporting ATPase activity;GO:0008083|growth factor activity;","K06734","CD320; CD320 antigen"]
["ENSG00000165501",344,334,343,552.402113989534,633,795,1030,0.496998133236065,-1.00868766196525,7.53169741515639e-30,1.31825208478708e-28,"down","yes","LRR1","protein_coding","chr14:49598697-49614672:+","gi|194375512|dbj|BAG56701.1|",1625,0,"unnamed protein product [Homo sapiens]","gi|322302003|ref|NR_037792.1|",1886,0,"Homo sapiens leucine rich repeat protein 1 (LRR1), transcript variant 4, non-coding RNA","Q96L50",630,0,"Leucine-rich repeat protein 1","MA2301_1",70.1,2e-12,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0043687|post-translational protein modification;GO:0016567|protein ubiquitination;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;",".","K10348","LRR1, PPIL5; LRR-repeat protein 1"]
["ENSG00000224184",76,56,51,98.3705836899628,106,140,196,0.496361228129507,-1.01053766711021,1.16700947580448e-06,5.64708448803732e-06,"down","yes","MIR3681HG","lincRNA","chr2:11848622-12578348:+",".",".",".",".","gi|571330849|ref|NR_110196.1|",2183,0,"Homo sapiens MIR3681 host gene (MIR3681HG), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam14309","DUF4378","Domain of unknown function (DUF4378).",".",".",".",".","."]
["ENSG00000161692",475,498,503,801.042284274351,929,1217,1402,0.496089523541315,-1.01132760428564,7.35995295360069e-38,1.60768711856229e-36,"down","yes","DBF4B","protein_coding","chr17:44708608-44752264:+","gi|578831440|ref|XP_006722161.1|",2564,0,"PREDICTED: protein DBF4 homolog B isoform X1 [Homo sapiens]","gi|307133758|ref|NR_036623.1|",2998,0,"Homo sapiens DBF4 zinc finger B (DBF4B), transcript variant 3, non-coding RNA","Q8NFT6",429,0,"Protein DBF4 homolog B",".",".",".",".","pfam07535","zf-DBF","DBF zinc finger. This domain is predicted to bind metal ions and is often found associated with pfam00533 and pfam02178. It was first identified in the Drosophila chiffon gene product, and is associated with initiation of DNA replication.","GO:0007049|cell cycle;GO:0008284|positive regulation of cell proliferation;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0010571|positive regulation of nuclear cell cycle DNA replication;","GO:0016235|aggresome;GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003676|nucleic acid binding;GO:0030295|protein kinase activator activity;GO:0019901|protein kinase binding;GO:0008270|zinc ion binding;",".","."]
["ENSG00000198771",328,351,316,539.070472876031,602,817,981,0.495794818769158,-1.01218490005631,1.60094344782974e-28,2.70394021206131e-27,"down","yes","RCSD1","protein_coding","chr1:167630093-167706249:+","gi|426332609|ref|XP_004027893.1|",1869,0,"PREDICTED: capZ-interacting protein [Gorilla gorilla gorilla]","gi|24266819|gb|AF545852.1|",3123,0,"Homo sapiens hypothetical protein mRNA, complete cds","Q6JBY9",657,0,"CapZ-interacting protein",".",".",".",".","pfam05177","RCSD","RCSD region. Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.","GO:0071474|cellular hyperosmotic response;GO:0003009|skeletal muscle contraction;","GO:0005884|actin filament;","GO:0051015|actin filament binding;","K18615","RCSD1, CAPZIP; CapZ-interacting protein"]
["ENSG00000223478",68,61,64,104.548843143377,118,163,183,0.495759199439777,-1.01228855115133,2.02981927785079e-07,1.0604321297721e-06,"down","yes","AL441992.1","antisense","chr9:128724445-128733194:+",".",".",".",".","gi|551867029|tpe|HG502460.1|",544,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000054490.1 (RP11-545E17.3 gene), antisense",".",".",".",".",".",".",".",".","pfam11754","Velvet","Velvet factor. The velvet factor is conserved in many fungal species and is found to have gained different roles depending on the organism's need, expanding the conserved role in developmental programmes. The velvet factor orthologues can be adapted to the fungal-specific life cycle and may be involved in diverse functions such as sclerotia formation and toxin production, as in A. parasiticus, nutrition-dependent sporulation, as in A. fumigatus, or the microconidia-to-macroconidia ratio and cell wall formation, as in the heterothallic fungus Fusarium verticilloides.",".",".",".",".","."]
["ENSG00000012171",199,139,149,263.037518709627,312,371,487,0.495261735232335,-1.01373693469252,1.02226341446551e-14,9.34474726929417e-14,"down","yes","SEMA3B","protein_coding","chr3:50267558-50277546:+","gi|343961397|dbj|BAK62288.1|",621,4e-71,"semaphorin-3B precursor [Pan troglodytes]","gi|21758321|dbj|AK098329.1|",3271,0,"Homo sapiens cDNA FLJ41010 fis, clone UTERU2018364, highly similar to SEMAPHORIN 3B PRECURSOR","Q13214",155,3e-69,"Semaphorin-3B",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0007411|axon guidance;GO:0007267|cell-cell signaling;GO:0050919|negative chemotaxis;","GO:0005783|endoplasmic reticulum;GO:0005615|extracellular space;","GO:0038191|neuropilin binding;","K06840","SEMA3; semaphorin 3"]
["ENSG00000181588",410,434,427,690.354467862552,827,917,1332,0.494987573017716,-1.01453578902999,4.08728366823222e-30,7.21937064037207e-29,"down","yes","MEX3D","protein_coding","chr19:1554669-1568058:-","gi|165905613|ref|NP_976049.3|",1815,0,"RNA-binding protein MEX3D isoform 1 [Homo sapiens]","gi|165905612|ref|NM_203304.3|",2850,0,"Homo sapiens mex-3 RNA binding family member D (MEX3D), transcript variant 1, mRNA","Q86XN8",703,0,"RNA-binding protein MEX3D",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0061157|mRNA destabilization;GO:0010609|mRNA localization resulting in posttranscriptional regulation of gene expression;","GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0017091|AU-rich element binding;GO:0046872|metal ion binding;GO:0003723|RNA binding;","K15686","MEX3, RKHD; RNA-binding protein MEX3 [EC:2.3.2.27]"]
["ENSG00000186575",253,225,233,386.185235068436,483,566,652,0.494875069817578,-1.0148637290948,4.84610250372852e-22,6.34135855440405e-21,"down","yes","NF2","protein_coding","chr22:29603556-29698598:+","gi|4557795|ref|NP_000259.1|",2838,0,"merlin isoform 1 [Homo sapiens]","gi|163644284|ref|NM_000268.3|",6025,0,"Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1, mRNA","P35240",1097,0,"Merlin",".",".",".",".","pfam00769","ERM","Ezrin/radixin/moesin family. This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.","GO:0030036|actin cytoskeleton organization;GO:0045216|cell-cell junction organization;GO:0007398|ectoderm development;GO:0021766|hippocampus development;GO:0070306|lens fiber cell differentiation;GO:0001707|mesoderm formation;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0022408|negative regulation of cell-cell adhesion;GO:0001953|negative regulation of cell-matrix adhesion;GO:0046426|negative regulation of JAK-STAT cascade;GO:0043409|negative regulation of MAPK cascade;GO:0006469|negative regulation of protein kinase activity;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045597|positive regulation of cell differentiation;GO:0051496|positive regulation of stress fiber assembly;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;GO:0014013|regulation of gliogenesis;GO:0035330|regulation of hippo signaling;GO:2000177|regulation of neural precursor cell proliferation;GO:1900180|regulation of protein localization to nucleus;GO:0031647|regulation of protein stability;GO:0072091|regulation of stem cell proliferation;GO:0014010|Schwann cell proliferation;","GO:0005912|adherens junction;GO:0045177|apical part of cell;GO:0044297|cell body;GO:0032154|cleavage furrow;GO:0030864|cortical actin cytoskeleton;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005769|early endosome;GO:0031527|filopodium membrane;GO:0030027|lamellipodium;GO:0016020|membrane;GO:0043005|neuron projection;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0003779|actin binding;","K16684","NF2; merlin"]
["ENSG00000198695",2695,2931,2516,4424.17944596496,5191,6637,7796,0.494143622597343,-1.01699767353446,4.91070329038897e-103,3.34691325318101e-101,"down","yes","MT-ND6","protein_coding","chrMT:14149-14673:-","gi|401666547|gb|AFP96222.1|",444,2e-52,"NADH dehydrogenase subunit 6 (mitochondrion) [Homo sapiens]","gi|1001886902|gb|KU754494.1|",525,0,"Homo sapiens haplogroup H44b mitochondrion, complete genome","P03923",174,2e-53,"NADH-ubiquinone oxidoreductase chain 6",".",".",".",".","pfam00499","Oxidored_q3","NADH-ubiquinone/plastoquinone oxidoreductase chain 6.","GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0042220|response to cocaine;GO:0042542|response to hydrogen peroxide;GO:0035094|response to nicotine;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:0070469|respiratory chain;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03884","ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:1.6.5.3]"]
["ENSG00000173083",186,197,188,310.117569646067,350,444,592,0.494032181859053,-1.01732307110125,5.35850481255248e-18,5.79343278164306e-17,"down","yes","HPSE","protein_coding","chr4:83292461-83335153:-","gi|94721347|ref|NP_006656.2|",2699,0,"heparanase isoform 1 preproprotein [Homo sapiens]","gi|315360641|ref|NM_006665.5|",4652,0,"Homo sapiens heparanase (HPSE), transcript variant 1, mRNA","Q9Y251",1044,0,"Heparanase",".",".",".",".","pfam03662","Glyco_hydro_79n","Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumor cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.","GO:0060055|angiogenesis involved in wound healing;GO:0007160|cell-matrix adhesion;GO:0006027|glycosaminoglycan catabolic process;GO:0030200|heparan sulfate proteoglycan catabolic process;GO:0043312|neutrophil degranulation;GO:0030194|positive regulation of blood coagulation;GO:0051798|positive regulation of hair follicle development;GO:0033690|positive regulation of osteoblast proliferation;GO:0051897|positive regulation of protein kinase B signaling;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0006029|proteoglycan metabolic process;GO:0051797|regulation of hair follicle development;GO:0061042|vascular wound healing;","GO:0005576|extracellular region;GO:0043231|intracellular membrane-bounded organelle;GO:0043202|lysosomal lumen;GO:0005765|lysosomal membrane;GO:0005764|lysosome;GO:0045121|membrane raft;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0035580|specific granule lumen;","GO:0004566|beta-glucuronidase activity;GO:0030305|heparanase activity;GO:0046983|protein dimerization activity;GO:0045545|syndecan binding;","K07964","HPSE; heparanase 1 [EC:3.2.1.166]"]
["ENSG00000123473",620,622,613,1008.29281983649,1155,1515,1815,0.493864947802034,-1.01781151820731,1.72101039865877e-50,5.06791581211149e-49,"down","yes","STIL","protein_coding","chr1:47250139-47314147:-","gi|115298661|ref|NP_003026.2|",6678,0,"SCL-interrupting locus protein isoform 2 [Homo sapiens]","gi|544711271|ref|NM_001282936.1|",5225,0,"Homo sapiens SCL/TAL1 interrupting locus (STIL), transcript variant 3, mRNA","Q15468",2576,0,"SCL-interrupting locus protein",".",".",".",".","pfam15253","STIL_N","SCL-interrupting locus protein N-terminus.","GO:0008283|cell proliferation;GO:0051298|centrosome duplication;GO:0007368|determination of left/right symmetry;GO:0000578|embryonic axis specification;GO:0033504|floor plate development;GO:0030900|forebrain development;GO:0001947|heart looping;GO:0001701|in utero embryonic development;GO:0007052|mitotic spindle organization;GO:0035264|multicellular organism growth;GO:0043066|negative regulation of apoptotic process;GO:0001843|neural tube closure;GO:0021915|neural tube development;GO:0030903|notochord development;GO:0071539|protein localization to centrosome;GO:0046599|regulation of centriole replication;GO:0007224|smoothened signaling pathway;","GO:0005814|centriole;GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;",".","K16724","STIL; SCL-interrupting locus protein"]
["ENSG00000281376",64,59,46,91.677181319012,117,127,161,0.493608970180055,-1.01855948257853,1.26876669289087e-06,6.11035504930813e-06,"down","yes","ABALON","antisense","chr20:31721507-31723409:+","gi|1622941|gb|AAB17354.1|",1212,9e-161,"Bcl-x beta [Homo sapiens]","gi|820948180|ref|NR_131907.1|",1903,0,"Homo sapiens apoptotic BCL2L1-antisense long non-coding RNA (ABALON), long non-coding RNA","Q07817",392,3e-131,"Bcl-2-like protein 1",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0008637|apoptotic mitochondrial changes;GO:0071839|apoptotic process in bone marrow;GO:0008283|cell proliferation;GO:0060154|cellular process regulating host cell cycle in response to virus;GO:0071312|cellular response to alkaloid;GO:0071230|cellular response to amino acid stimulus;GO:0071480|cellular response to gamma radiation;GO:0019221|cytokine-mediated signaling pathway;GO:0006897|endocytosis;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0009566|fertilization;GO:0007281|germ cell development;GO:0040007|growth;GO:0097284|hepatocyte apoptotic process;GO:0001701|in utero embryonic development;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008584|male gonad development;GO:0070584|mitochondrion morphogenesis;GO:0007093|mitotic cell cycle checkpoint;GO:2000811|negative regulation of anoikis;GO:0043066|negative regulation of apoptotic process;GO:0010507|negative regulation of autophagy;GO:1900118|negative regulation of execution phase of apoptosis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0043524|negative regulation of neuron apoptotic process;GO:1903077|negative regulation of protein localization to plasma membrane;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0051402|neuron apoptotic process;GO:0001541|ovarian follicle development;GO:0008284|positive regulation of cell proliferation;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;GO:0032465|regulation of cytokinesis;GO:0046902|regulation of mitochondrial membrane permeability;GO:0051881|regulation of mitochondrial membrane potential;GO:0001836|release of cytochrome c from mitochondria;GO:0046898|response to cycloheximide;GO:0034097|response to cytokine;GO:0007283|spermatogenesis;GO:0019050|suppression by virus of host apoptotic process;","GO:0097136|Bcl-2 family protein complex;GO:0030054|cell junction;GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;GO:0031965|nuclear membrane;GO:0030672|synaptic vesicle membrane;","GO:0051434|BH3 domain binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;","K04570","BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)"]
["ENSG00000153237",13,20,12,24.538499847574,32,34,42,0.493258659183003,-1.0195837171251,0.0121487416605439,0.0317255522811496,"down","yes","CCDC148","protein_coding","chr2:158171081-158456753:-","gi|284172495|ref|NP_620158.3|",2700,0,"coiled-coil domain-containing protein 148 isoform 1 [Homo sapiens]","gi|284172494|ref|NM_138803.3|",2846,0,"Homo sapiens coiled-coil domain containing 148 (CCDC148), transcript variant 1, mRNA",".",".",".",".",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).",".",".",".",".","."]
["ENSG00000236671",14,13,12,21.2525572255843,27,34,32,0.493108507572236,-1.02002295110046,0.0177008345009785,0.0442188441723705,"down","yes","PRKG1-AS1","antisense","chr10:52230742-52314507:-","gi|795332929|ref|XP_011738590.1|",169,6e-11,"PREDICTED: uncharacterized protein LOC105481034 isoform X1 [Macaca nemestrina]","gi|551868550|tpe|HG502911.1|",935,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000048110.1 (RP11-573I11.2 gene), antisense",".",".",".",".",".",".",".",".","pfam15512","CAF-1_p60_C","Chromatin assembly factor complex 1 subunit p60, C-terminal. CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.",".",".",".",".","."]
["ENSG00000134802",664,587,536,970.323204780883,1163,1442,1696,0.493103323847186,-1.02003811728319,2.19210558632819e-50,6.43551484765573e-49,"down","yes","SLC43A3","protein_coding","chr11:57406954-57427580:-","gi|18252047|ref|NP_060081.1|",2476,0,"solute carrier family 43 member 3 isoform 1 [Homo sapiens]","gi|499589959|ref|NM_014096.3|",2619,0,"Homo sapiens solute carrier family 43 member 3 (SLC43A3), transcript variant 1, mRNA","Q8NBI5",958,0,"Solute carrier family 43 member 3",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;",".","K08230","SLC43A3; MFS transporter, LAT3 family, solute carrier family 43, member 3"]
["ENSG00000137642",130,120,105,192.817345345262,223,295,339,0.492654439213127,-1.02135203781117,1.49472739957978e-12,1.19776909360594e-11,"down","yes","SORL1","protein_coding","chr11:121452203-121633693:+","gi|296452912|sp|Q92673.2|SORL_HUMAN",11678,0,"RecName: Full=Sortilin-related receptor; AltName: Full=Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Short=LDLR relative with 11 ligand-binding repeats; Short=LR11; AltName: Full=SorLA-1; AltName: Full=Sorting protein-related receptor containing LDLR class A repeats; Short=SorLA; Flags: Precursor","gi|307611954|ref|NM_003105.5|",10898,0,"Homo sapiens sortilin-related receptor, L(DLR class) A repeats containing (SORL1), mRNA","Q92673",4506,0,"Sortilin-related receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0044267|cellular protein metabolic process;GO:0008203|cholesterol metabolic process;GO:0006869|lipid transport;GO:1902430|negative regulation of beta-amyloid formation;GO:1902960|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0043407|negative regulation of MAP kinase activity;GO:1902963|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902997|negative regulation of neurofibrillary tangle assembly;GO:0050768|negative regulation of neurogenesis;GO:1901215|negative regulation of neuron death;GO:0032091|negative regulation of protein binding;GO:0032460|negative regulation of protein oligomerization;GO:1902948|negative regulation of tau-protein kinase activity;GO:1902771|positive regulation of choline O-acetyltransferase activity;GO:1902955|positive regulation of early endosome to recycling endosome transport;GO:2001137|positive regulation of endocytic recycling;GO:1902953|positive regulation of ER to Golgi vesicle-mediated transport;GO:0045732|positive regulation of protein catabolic process;GO:0070863|positive regulation of protein exit from endoplasmic reticulum;GO:1902966|positive regulation of protein localization to early endosome;GO:0006892|post-Golgi vesicle-mediated transport;GO:0034067|protein localization to Golgi apparatus;GO:0051604|protein maturation;GO:0045053|protein retention in Golgi apparatus;GO:0006605|protein targeting;GO:0006622|protein targeting to lysosome;GO:0006898|receptor-mediated endocytosis;GO:0014910|regulation of smooth muscle cell migration;","GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0010008|endosome membrane;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0031985|Golgi cisterna;GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;GO:0034362|low-density lipoprotein particle;GO:0016020|membrane;GO:0005641|nuclear envelope lumen;GO:0055037|recycling endosome;GO:0005802|trans-Golgi network;","GO:0030306|ADP-ribosylation factor binding;GO:0001540|beta-amyloid binding;GO:0030169|low-density lipoprotein particle binding;GO:0005041|low-density lipoprotein receptor activity;GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSG00000012963",765,740,781,1245.56701312519,1424,1881,2241,0.492429928097656,-1.02200964864994,4.48371479271252e-56,1.47078045785441e-54,"down","yes","UBR7","protein_coding","chr14:93207056-93229215:+","gi|685555621|ref|XP_003902240.2|",2311,0,"PREDICTED: LOW QUALITY PROTEIN: putative E3 ubiquitin-protein ligase UBR7 [Papio anubis]","gi|154426321|ref|NM_175748.3|",3694,0,"Homo sapiens ubiquitin protein ligase E3 component n-recognin 7 (putative) (UBR7), transcript variant 2, mRNA","Q8N806",809,0,"Putative E3 ubiquitin-protein ligase UBR7",".",".",".",".","pfam02207","zf-UBR","Putative zinc finger in N-recognin (UBR box). This region is found in E3 ubiquitin ligases that recognize N-recognins.","GO:0016567|protein ubiquitination;",".","GO:0016740|transferase activity;GO:0008270|zinc ion binding;","K11979","UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"]
["ENSG00000126759",14,15,15,23.9065056426192,23,38,47,0.49238813094714,-1.02213210891812,0.0120808602142516,0.03156537954653,"down","yes","CFP","protein_coding","chrX:47623172-47630305:-","gi|119579723|gb|EAW59319.1|",1661,0,"complement factor properdin, isoform CRA_c [Homo sapiens]","gi|34528400|dbj|AK122955.1|",4022,0,"Homo sapiens cDNA FLJ16673 fis, clone THYMU3003403, highly  similar to Properdin precursor","P27918",626,0,"Properdin",".",".",".",".","pfam00090","TSP_1","Thrombospondin type 1 domain.","GO:0006956|complement activation;GO:0006957|complement activation, alternative pathway;GO:0042742|defense response to bacterium;GO:0006955|immune response;GO:0043312|neutrophil degranulation;GO:0030449|regulation of complement activation;","GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0035580|specific granule lumen;","GO:0004252|serine-type endopeptidase activity;","K15412","CFP; complement factor properdin"]
["ENSG00000176014",1960,1826,1708,2992.58492374326,3587,4320,5399,0.491347557803049,-1.02518420978573,1.82434897431777e-135,1.78619507698686e-133,"down","yes","TUBB6","protein_coding","chr18:12307669-12344320:+","gi|14210536|ref|NP_115914.1|",2123,0,"tubulin beta-6 chain isoform 1 [Homo sapiens]","gi|21751326|dbj|AK092677.1|",2160,0,"Homo sapiens cDNA FLJ35358 fis, clone PUAEN2000497, highly similar to Tubulin beta-6 chain","Q9BUF5",822,0,"Tubulin beta-6 chain","ECU03g0820i",679,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005874|microtubule;GO:0005634|nucleus;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07375","TUBB; tubulin beta"]
["ENSG00000163032",19,13,20,28.4826709104683,36,45,44,0.490601145166192,-1.02737749343445,0.00655057830378823,0.01816382322074,"down","yes","VSNL1","protein_coding","chr2:17539126-17657018:+","gi|697499026|ref|XP_009678838.1|",1044,1e-132,"PREDICTED: visinin-like protein 1 isoform X2 [Struthio camelus australis]","gi|13874453|dbj|AB060821.1|",1987,0,"Macaca fascicularis brain cDNA clone:QflA-12232, similar to human visinin-lik1 1(VSNL1), mRNA, NM_003385.2","P62762",397,1e-130,"Visinin-like protein 1","SPAC18B11.04",231,4e-69,"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0019722|calcium-mediated signaling;GO:0007417|central nervous system development;GO:0046676|negative regulation of insulin secretion;GO:0045921|positive regulation of exocytosis;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0005509|calcium ion binding;",".","."]
["ENSG00000050344",1745,1667,1459,2654.9499008865,3199,3834,4772,0.49056592285623,-1.02748107426913,7.22847899130757e-112,5.62189124130405e-110,"down","yes","NFE2L3","protein_coding","chr7:26152240-26187125:+","gi|225735557|ref|NP_004280.5|",3190,0,"nuclear factor erythroid 2-related factor 3 [Homo sapiens]","gi|225735556|ref|NM_004289.6|",3686,0,"Homo sapiens nuclear factor, erythroid 2 like 3 (NFE2L3), mRNA","Q9Y4A8",1233,0,"Nuclear factor erythroid 2-related factor 3",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0045893|positive regulation of transcription, DNA-templated;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09040","NFE2L1_3; nuclear factor erythroid 2-related factor 1/3"]
["ENSG00000178821",17,13,12,23.0057436199724,37,29,33,0.490150732877939,-1.02870261477217,0.0161187063827556,0.0408484573263158,"down","yes","TMEM52","protein_coding","chr1:1917590-1919273:-","gi|332807408|ref|XP_001155815.2|",925,1e-121,"PREDICTED: transmembrane protein 52 [Pan troglodytes]","gi|37182210|gb|AY358544.1|",1112,0,"Homo sapiens clone DNA125151 ERHC3048 (UNQ3048) mRNA, complete cds","Q8NDY8",279,5e-91,"Transmembrane protein 52",".",".",".",".","pfam14979","TMEM52","Transmembrane 52. This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 160 and 236 amino acids in length. There is a conserved LLCG sequence motif. The function of this family is unknown.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000186638",181,139,134,247.713496142368,313,356,428,0.489110776170834,-1.03176684416186,6.48565552037974e-15,6.01709108595885e-14,"down","yes","KIF24","protein_coding","chr9:34252381-34311371:-","gi|767954844|ref|XP_011516162.1|",7016,0,"PREDICTED: kinesin-like protein KIF24 isoform X2 [Homo sapiens]","gi|767954849|ref|XM_011517863.1|",6131,0,"PREDICTED: Homo sapiens kinesin family member 24 (KIF24), transcript variant X4, mRNA","Q5T7B8",2690,0,"Kinesin-like protein KIF24","ECU11g0470",265,2e-74,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0060271|cilium morphogenesis;GO:0007019|microtubule depolymerization;GO:0007018|microtubule-based movement;","GO:0005814|centriole;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0032991|macromolecular complex;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0042802|identical protein binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10393","KIF2_24, MCAK; kinesin family member 2/24"]
["ENSG00000142765",34,27,33,51.4149394574908,59,80,90,0.48894708771331,-1.03224974509614,0.000200290911175192,0.000731530220554271,"down","yes","SYTL1","protein_coding","chr1:27342020-27353937:+","gi|21756849|dbj|BAC04970.1|",800,4e-96,"unnamed protein product [Homo sapiens]","gi|21756848|dbj|AK097172.1|",2675,0,"Homo sapiens cDNA FLJ39853 fis, clone SPLEN2014911","Q8IYJ3",313,8e-94,"Synaptotagmin-like protein 1",".",".",".",".","pfam00168","C2","C2 domain.","GO:0048791|calcium ion-dependent exocytosis of neurotransmitter;GO:0006887|exocytosis;GO:0006886|intracellular protein transport;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0006906|vesicle fusion;","GO:0070382|exocytic vesicle;GO:0070062|extracellular exosome;GO:0019897|extrinsic component of plasma membrane;GO:0042470|melanosome;GO:0031528|microvillus membrane;GO:0005886|plasma membrane;GO:0098793|presynapse;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0030276|clathrin binding;GO:0042043|neurexin family protein binding;GO:0017137|Rab GTPase binding;GO:0019905|syntaxin binding;","K17598","SYTL; synaptotagmin-like protein"]
["ENSG00000225077",17,17,11,24.5003435029688,28,35,47,0.488360300383844,-1.03398216886028,0.0099858147607066,0.0265371169887722,"down","yes","LINC00337","lincRNA","chr1:6234692-6239444:+","gi|119591930|gb|EAW71524.1|",806,3e-100,"hypothetical protein MGC40168, partial [Homo sapiens]","gi|551895154|tpe|HG491651.1|",1266,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000003686.1 (LINC00337 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000137267",335,318,307,525.134785634922,598,761,996,0.487862406854373,-1.03545377689155,1.93992941861239e-30,3.48717228575917e-29,"down","yes","TUBB2A","protein_coding","chr6:3153669-3157526:-","gi|586480181|ref|XP_006870616.1|",2227,0,"PREDICTED: tubulin beta-2A chain-like isoform X2 [Chrysochloris asiatica]","gi|68299771|ref|NM_001069.2|",1595,0,"Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA","P85108",862,0,"Tubulin beta-2A chain","ECU03g0820i",728,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07375","TUBB; tubulin beta"]
["ENSG00000160886",294,266,244,440.519826138151,564,632,753,0.487644981084499,-1.03609688649591,3.10711938631978e-25,4.62067222230809e-24,"down","yes","LY6K","protein_coding","chr8:142700111-142705127:+","gi|530389171|ref|XP_005251047.1|",414,3e-43,"PREDICTED: lymphocyte antigen 6K isoform X2 [Homo sapiens]","gi|21751165|dbj|AK092545.1|",2685,0,"Homo sapiens cDNA FLJ35226 fis, clone PROST2001138, moderately similar to Homo sapiens cDNA for differentially expressed CO16 gene","Q17RY6",148,4e-39,"Lymphocyte antigen 6K",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0001669|acrosomal vesicle;GO:0031225|anchored component of membrane;GO:0005576|extracellular region;GO:0045121|membrane raft;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000012124",45,35,53,72.9357345793072,78,107,144,0.487438368145761,-1.03670827928976,2.10851866049051e-05,8.85073077770206e-05,"down","yes","CD22","protein_coding","chr19:35319261-35347355:+","gi|157168355|ref|NP_001762.2|",4270,0,"B-cell receptor CD22 isoform 1 precursor [Homo sapiens]","gi|297374826|ref|NM_001771.3|",3268,0,"Homo sapiens CD22 molecule (CD22), transcript variant 1, mRNA","P20273",1649,0,"B-cell receptor CD22",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0030246|carbohydrate binding;","K06467","CD22, SIGLEC2; CD22 antigen"]
["ENSG00000120647",295,239,220,411.743622091843,473,624,744,0.487420567660338,-1.03676096521406,1.32573011463613e-23,1.84226818811972e-22,"down","yes","CCDC77","protein_coding","chr12:389273-442645:+","gi|14150165|ref|NP_115734.1|",2200,0,"coiled-coil domain-containing protein 77 isoform a [Homo sapiens]","gi|194306656|ref|NM_032358.3|",2368,0,"Homo sapiens coiled-coil domain containing 77 (CCDC77), transcript variant 1, mRNA","Q9BR77",852,0,"Coiled-coil domain-containing protein 77",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.",".","GO:0005813|centrosome;GO:0016020|membrane;",".","K16757","CCDC77; coiled-coil domain-containing protein 77"]
["ENSG00000204060",27,23,21,38.8606002985902,43,71,58,0.487397038251295,-1.03683061057447,0.00156032087938438,0.00492802834805404,"down","yes","FOXO6","protein_coding","chr1:41361922-41383590:+","gi|831241310|ref|XP_012666335.1|",950,1e-115,"PREDICTED: forkhead box protein O6 [Otolemur garnettii]","gi|21553250|gb|AC093151.2|",1977,0,"Homo sapiens chromosome 1 clone RP11-399E6, complete sequence","A8MYZ6",363,2e-114,"Forkhead box protein O6","ECU01g0470",72.4,3e-13,"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0007613|memory;GO:0060999|positive regulation of dendritic spine development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["ENSG00000130748",287,317,293,492.256600360718,588,676,939,0.487212523999771,-1.03737687609276,4.96348678762607e-26,7.64052140141514e-25,"down","yes","TMEM160","protein_coding","chr19:47045907-47048630:-","gi|724893670|ref|XP_010375716.1|",722,3e-93,"PREDICTED: transmembrane protein 160 [Rhinopithecus roxellana]","gi|38197223|gb|BC002907.2|",658,0,"Homo sapiens transmembrane protein 160, mRNA (cDNA clone MGC:10300 IMAGE:3941377), complete cds","Q9NX00",274,1e-91,"Transmembrane protein 160",".",".",".",".","pfam02656","DUF202","Domain of unknown function (DUF202). This family consists of hypothetical proteins some of which are putative membrane proteins. No functional information or experimental verification of function is known. This domain is around 100 amino acids long.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000144868",52,47,46,79.4830352276382,93,123,138,0.486952299855367,-1.03814763702025,2.97863337455776e-06,1.3784040433894e-05,"down","yes","TMEM108","protein_coding","chr3:133038391-133397792:+","gi|675769770|ref|XP_008974351.1|",1869,0,"PREDICTED: transmembrane protein 108 isoform X2 [Pan paniscus]","gi|12697924|dbj|AB051477.1|",4807,0,"Homo sapiens mRNA for KIAA1690 protein, partial cds","Q6UXF1",724,0,"Transmembrane protein 108",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:0097484|dendrite extension;GO:0021542|dentate gyrus development;GO:0098815|modulation of excitatory postsynaptic potential;GO:0031175|neuron projection development;GO:0051388|positive regulation of neurotrophin TRK receptor signaling pathway;GO:0097106|postsynaptic density organization;GO:0006898|receptor-mediated endocytosis;GO:0008090|retrograde axon cargo transport;","GO:0030424|axon;GO:1904115|axon cytoplasm;GO:0030054|cell junction;GO:0030425|dendrite;GO:0005769|early endosome;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0036477|somatodendritic compartment;",".",".","."]
["ENSG00000188488",53,65,49,91.3442008649967,90,144,180,0.486919200154809,-1.03824570493551,2.17085484836388e-06,1.02072739338802e-05,"down","yes","SERPINA5","protein_coding","chr14:94561442-94593120:+","gi|194018472|ref|NP_000615.3|",2025,0,"plasma serine protease inhibitor preproprotein [Homo sapiens]","gi|401782581|ref|NM_000624.5|",2337,0,"Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 (SERPINA5), mRNA","P05154",784,0,"Plasma serine protease inhibitor","all0778",171,6e-46,"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0007596|blood coagulation;GO:0007342|fusion of sperm to egg plasma membrane;GO:0006869|lipid transport;GO:0051346|negative regulation of hydrolase activity;GO:0061107|seminal vesicle development;GO:0007283|spermatogenesis;","GO:0002080|acrosomal membrane;GO:0009897|external side of plasma membrane;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016020|membrane;GO:0031091|platelet alpha granule;GO:0031094|platelet dense tubular network;GO:0097181|protein C inhibitor-coagulation factor V complex;GO:0097182|protein C inhibitor-coagulation factor Xa complex;GO:0097183|protein C inhibitor-coagulation factor XI complex;GO:0036029|protein C inhibitor-KLK3 complex;GO:0036030|protein C inhibitor-plasma kallikrein complex;GO:0036026|protein C inhibitor-PLAT complex;GO:0036027|protein C inhibitor-PLAU complex;GO:0036028|protein C inhibitor-thrombin complex;GO:0036025|protein C inhibitor-TMPRSS11E complex;GO:0036024|protein C inhibitor-TMPRSS7 complex;GO:0032991|macromolecular complex;","GO:0032190|acrosin binding;GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;GO:0031210|phosphatidylcholine binding;GO:0002020|protease binding;GO:0001972|retinoic acid binding;GO:0004867|serine-type endopeptidase inhibitor activity;","K03913","SERPINA5, PCI; protein C inhibitor"]
["ENSG00000177469",8353,8309,7575,13292.1037147981,15578,19269,24625,0.486784470942899,-1.03864494994792,1.60886699072304e-238,3.73877427916457e-236,"down","yes","CAVIN1","protein_coding","chr17:42402452-42423517:-","gi|426348158|ref|XP_004041706.1|",1752,0,"PREDICTED: LOW QUALITY PROTEIN: polymerase I and transcript release factor [Gorilla gorilla gorilla]","gi|694966913|ref|XM_009432156.1|",3671,0,"PREDICTED: Pan troglodytes polymerase I and transcript release factor (PTRF), mRNA","Q6NZI2",541,2e-179,"Caveolae-associated protein 1",".",".",".",".","pfam15237","PTRF_SDPR","PTRF/SDPR family. This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.","GO:2000147|positive regulation of cell motility;GO:0006355|regulation of transcription, DNA-templated;GO:0009303|rRNA transcription;GO:0006363|termination of RNA polymerase I transcription;GO:0006361|transcription initiation from RNA polymerase I promoter;","GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0042802|identical protein binding;GO:0003723|RNA binding;GO:0042134|rRNA primary transcript binding;","K19387","PTRF; polymerase I and transcript release factor"]
["ENSG00000170779",875,920,852,1454.02024339164,1655,2177,2684,0.485971852197232,-1.04105534046265,1.03796149008687e-65,3.92552965113638e-64,"down","yes","CDCA4","protein_coding","chr14:105009573-105021148:-","gi|22027509|ref|NP_060425.2|",1278,8e-168,"cell division cycle-associated protein 4 [Homo sapiens]","gi|198278565|ref|NM_017955.3|",2453,0,"Homo sapiens cell division cycle associated 4 (CDCA4), transcript variant 1, mRNA","Q9BXL8",496,3e-169,"Cell division cycle-associated protein 4",".",".",".",".","pfam06031","SERTA","SERTA motif. This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.",".","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000141560",256,266,304,455.189601186779,530,647,864,0.485540372886301,-1.04233683355555,1.30768947282033e-22,1.74310397731572e-21,"down","yes","FN3KRP","protein_coding","chr17:82716683-82730328:+","gi|20149680|ref|NP_078895.2|",1593,0,"ketosamine-3-kinase [Homo sapiens]","gi|222136645|ref|NM_024619.3|",1817,0,"Homo sapiens fructosamine 3 kinase related protein (FN3KRP), transcript variant 1, mRNA","Q9HA64",618,0,"Ketosamine-3-kinase","alr5126",161,1e-43,"COG3001","pfam03881","Fructosamin_kin","Fructosamine kinase. This family includes eukaryotic fructosamine-3-kinase enzymes. The family also includes bacterial members that have not been characterized but probably have a similar or identical function.","GO:0043687|post-translational protein modification;","GO:0005829|cytosol;","GO:0016301|kinase activity;","K15523","FN3KRP; protein-ribulosamine 3-kinase [EC:2.7.1.172]"]
["ENSG00000187098",421,394,384,658.444512926415,777,949,1221,0.485474068745099,-1.04253385772275,6.51528154785494e-39,1.47496186027026e-37,"down","yes","MITF","protein_coding","chr3:69739435-69968337:+","gi|38156699|ref|NP_937802.1|",2232,0,"microphthalmia-associated transcription factor isoform 1 [Homo sapiens]","gi|296841078|ref|NM_198159.2|",4814,0,"Homo sapiens microphthalmia-associated transcription factor (MITF), transcript variant 1, mRNA","O75030",857,0,"Microphthalmia-associated transcription factor",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0046849|bone remodeling;GO:0043010|camera-type eye development;GO:0044336|canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0045165|cell fate commitment;GO:0030318|melanocyte differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030316|osteoclast differentiation;GO:2000144|positive regulation of DNA-templated transcription, initiation;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0065003|macromolecular complex assembly;GO:0042127|regulation of cell proliferation;GO:0045670|regulation of osteoclast differentiation;GO:2001141|regulation of RNA biosynthetic process;GO:0006355|regulation of transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0070888|E-box binding;GO:0046983|protein dimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09455","MITF; microphthalmia-associated transcription factor"]
["ENSG00000253683",100,92,67,141.497021040451,150,209,282,0.485001623248273,-1.04393851903437,4.09353201735378e-09,2.4946617867526e-08,"down","yes","AC027309.2","processed_pseudogene","chr5:172656522-172656713:-",".",".",".",".","gi|429503510|ref|NG_009256.2|",192,9e-95,"Homo sapiens translation machinery associated 7 homolog (S. cerevisiae) pseudogene (LOC100130394) on chromosome 5",".",".",".",".",".",".",".",".","pfam15485","DUF4643","Domain of unknown function (DUF4643). This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.",".",".",".",".","."]
["ENSG00000225205",22,17,18,31.4637758976293,44,45,49,0.483794192671483,-1.0475346431684,0.00338599861567369,0.00999527721137346,"down","yes","AC078883.1","antisense","chr2:172480840-172556596:-","gi|90085411|dbj|BAE91446.1|",242,5e-22,"unnamed protein product [Macaca fascicularis]","gi|551847631|tpe|HG494876.1|",1397,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000333834.2 (AC093818.1 gene), antisense","Q8BFP9",57,2e-07,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial",".",".",".",".","pfam11039","DUF2824","Protein of unknown function (DUF2824). This family of proteins has no known function. Some members in the family are annotated as the P22 head assembly protein gp14 however this cannot be confirmed.","GO:0008283|cell proliferation;GO:0007166|cell surface receptor signaling pathway;GO:0006006|glucose metabolic process;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;GO:0035556|intracellular signal transduction;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0018105|peptidyl-serine phosphorylation;GO:0006468|protein phosphorylation;GO:0010510|regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906|regulation of glucose metabolic process;","GO:0005967|mitochondrial pyruvate dehydrogenase complex;GO:0005739|mitochondrion;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0045254|pyruvate dehydrogenase complex;","GO:0005524|ATP binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0044877|macromolecular complex binding;GO:0004740|pyruvate dehydrogenase (acetyl-transferring) kinase activity;","K12077","PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]"]
["ENSG00000120868",510,492,436,792.271648409517,956,1222,1348,0.483444251360947,-1.04857856076381,2.05597938375121e-42,5.08406799407607e-41,"down","yes","APAF1","protein_coding","chr12:98645141-98735433:+","gi|32483361|ref|NP_863658.1|",6420,0,"apoptotic protease-activating factor 1 isoform d [Homo sapiens]","gi|32483360|ref|NM_181868.1|",7055,0,"Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 4, mRNA","O14727",2451,0,"Apoptotic protease-activating factor 1",".",".",".",".","pfam00931","NB-ARC","NB-ARC domain.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008635|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0007568|aging;GO:0006915|apoptotic process;GO:0010659|cardiac muscle cell apoptotic process;GO:0030154|cell differentiation;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0030900|forebrain development;GO:0034349|glial cell apoptotic process;GO:0097193|intrinsic apoptotic signaling pathway;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070317|negative regulation of G0 to G1 transition;GO:0007399|nervous system development;GO:0001843|neural tube closure;GO:0051402|neuron apoptotic process;GO:0043312|neutrophil degranulation;GO:0043065|positive regulation of apoptotic process;GO:2001235|positive regulation of apoptotic signaling pathway;GO:0051260|protein homooligomerization;GO:1902510|regulation of apoptotic DNA fragmentation;GO:0042981|regulation of apoptotic process;GO:0072432|response to G1 DNA damage checkpoint signaling;GO:0001666|response to hypoxia;GO:0007584|response to nutrient;","GO:0043293|apoptosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0034774|secretory granule lumen;","GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0008656|cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0031072|heat shock protein binding;GO:0042802|identical protein binding;GO:0000166|nucleotide binding;","K02084","APAF1; apoptotic protease-activating factor"]
["ENSG00000002587",39,37,29,57.4436186447827,56,79,129,0.483160348085853,-1.04942603419624,0.000141442720142632,0.000528509633391909,"down","yes","HS3ST1","protein_coding","chr4:11393150-11429765:-","gi|4826764|ref|NP_005105.1|",1551,0,"heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor [Homo sapiens]","gi|14209802|gb|AC073991.2|",6966,0,"Homo sapiens BAC clone RP11-512I20 from 4, complete sequence","O14792",602,0,"Heparan sulfate glucosamine 3-O-sulfotransferase 1",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0006024|glycosaminoglycan biosynthetic process;","GO:0005796|Golgi lumen;GO:0016021|integral component of membrane;","GO:0008467|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity;GO:0008146|sulfotransferase activity;","K01024","HS3ST1; [heparan sulfate]-glucosamine 3-sulfotransferase 1 [EC:2.8.2.23]"]
["ENSG00000145569",281,247,288,451.173840571097,573,637,797,0.48267654805344,-1.05087136304775,7.99166937695237e-25,1.16334580334081e-23,"down","yes","OTULINL","protein_coding","chr5:14581775-14615007:+","gi|9506641|ref|NP_061891.1|",1923,0,"inactive ubiquitin thioesterase FAM105A [Homo sapiens]","gi|218082878|ref|NM_019018.2|",3590,0,"Homo sapiens family with sequence similarity 105 member A (FAM105A), mRNA",".",".",".",".",".",".",".",".","pfam05518","Totivirus_coat","Totivirus coat protein.",".",".",".",".","."]
["ENSG00000131746",103,89,71,144.805863085503,178,215,253,0.481938033790251,-1.05308043409717,4.81638855663643e-10,3.20892927393449e-09,"down","yes","TNS4","protein_coding","chr17:40475828-40501597:-","gi|157738639|ref|NP_116254.4|",3387,0,"tensin-4 precursor [Homo sapiens]","gi|157738638|ref|NM_032865.5|",4067,0,"Homo sapiens tensin 4 (TNS4), mRNA","Q8IZW8",1309,0,"Tensin-4",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0006915|apoptotic process;GO:0008104|protein localization;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005925|focal adhesion;","GO:0003779|actin binding;","K18080","TNS; tensin"]
["ENSG00000117724",3012,2731,2549,4575.60782701108,5511,6793,8148,0.481697945557314,-1.05379932404654,5.8524570144133e-183,9.0305752715203e-181,"down","yes","CENPF","protein_coding","chr1:214603195-214664588:+","gi|55770834|ref|NP_057427.3|",14557,0,"centromere protein F [Homo sapiens]","gi|55770833|ref|NM_016343.3|",10290,0,"Homo sapiens centromere protein F (CENPF), mRNA","P49454",2989,0,"Centromere protein F",".",".",".",".","pfam10481","CENP-F_N","Cenp-F N-terminal domain. Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein.","GO:0030154|cell differentiation;GO:0051301|cell division;GO:0008283|cell proliferation;GO:0007059|chromosome segregation;GO:0071897|DNA biosynthetic process;GO:0001822|kidney development;GO:0051382|kinetochore assembly;GO:0051310|metaphase plate congression;GO:0000278|mitotic cell cycle;GO:0007094|mitotic spindle assembly checkpoint;GO:0007517|muscle organ development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0015031|protein transport;GO:0051726|regulation of cell cycle;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0016202|regulation of striated muscle tissue development;GO:0042493|response to drug;GO:0021591|ventricular system development;","GO:0005930|axoneme;GO:0005813|centrosome;GO:0000775|chromosome, centromeric region;GO:0036064|ciliary basal body;GO:0097539|ciliary transition fiber;GO:0000940|condensed chromosome outer kinetochore;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0030496|midbody;GO:0005635|nuclear envelope;GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0045120|pronucleus;GO:0005819|spindle;GO:0000922|spindle pole;","GO:0003682|chromatin binding;GO:0070840|dynein complex binding;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;GO:0008134|transcription factor binding;","K11499","CENPF; centromere protein F"]
["ENSG00000064199",24,16,25,35.960172748295,38,64,59,0.481065926155268,-1.05569347777384,0.00207733036736021,0.00640875689789567,"down","yes","SPA17","protein_coding","chr11:124673798-124697518:+","gi|8394343|ref|NP_059121.1|",697,9e-81,"sperm surface protein Sp17 [Homo sapiens]","gi|767970270|ref|XM_011542870.1|",3557,0,"PREDICTED: Homo sapiens sperm autoantigenic protein 17 (SPA17), transcript variant X1, mRNA","Q15506",273,3e-82,"Sperm surface protein Sp17",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007339|binding of sperm to zona pellucida;GO:0003351|epithelial cilium movement;GO:0007338|single fertilization;GO:0007283|spermatogenesis;","GO:0005929|cilium;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0031514|motile cilium;GO:0035686|sperm fibrous sheath;GO:0097228|sperm principal piece;",".",".","."]
["ENSG00000104267",41,49,64,85.7261007786731,96,137,151,0.4810338685176,-1.05578962038848,4.96903125428529e-06,2.24455912957037e-05,"down","yes","CA2","protein_coding","chr8:85463852-85481493:+","gi|695721874|pdb|4PQ7|A",1384,0,"Chain A, The Crystal Structure Of The Human Carbonic Anhydrase Ii In Complex With A Sulfamide Inhibitor","gi|157952216|ref|NM_000067.2|",1666,0,"Homo sapiens carbonic anhydrase II (CA2), transcript variant 1, mRNA","P00918",538,0,"Carbonic anhydrase 2","all2929",134,2e-34,"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0038166|angiotensin-activated signaling pathway;GO:0015701|bicarbonate transport;GO:0015670|carbon dioxide transport;GO:0071498|cellular response to fluid shear stress;GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045780|positive regulation of bone resorption;GO:0032849|positive regulation of cellular pH reduction;GO:2001150|positive regulation of dipeptide transmembrane transport;GO:0045672|positive regulation of osteoclast differentiation;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0044070|regulation of anion transport;GO:2001225|regulation of chloride transport;GO:0051453|regulation of intracellular pH;GO:0043627|response to estrogen;GO:0009268|response to pH;GO:0048545|response to steroid hormone;GO:0010043|response to zinc ion;GO:0046903|secretion;","GO:0045177|apical part of cell;GO:0030424|axon;GO:0016323|basolateral plasma membrane;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005902|microvillus;GO:0043209|myelin sheath;GO:0005886|plasma membrane;","GO:0004064|arylesterase activity;GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;","K18245","CA2; carbonic anhydrase 2 [EC:4.2.1.1]"]
["ENSG00000157456",885,872,838,1434.44540699294,1611,2186,2660,0.480946696111704,-1.0560510876211,1.61221321461404e-68,6.45152873101154e-67,"down","yes","CCNB2","protein_coding","chr15:59105078-59125045:+","gi|371905558|emb|CAO99274.1|",2011,0,"cyclin B2 [Homo sapiens]","gi|371905557|emb|AM851054.1|",2490,0,"Homo sapiens mRNA for cyclin B2 (CCNB2V gene), short variant","O95067",757,0,"G2/mitotic-specific cyclin-B2","SPBC582.03",227,2e-64,"COG5024","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0051301|cell division;GO:0000086|G2/M transition of mitotic cell cycle;GO:0040007|growth;GO:0001701|in utero embryonic development;GO:0007077|mitotic nuclear envelope disassembly;GO:0051726|regulation of cell cycle;GO:0043029|T cell homeostasis;GO:0048538|thymus development;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0015630|microtubule cytoskeleton;GO:0005634|nucleus;","GO:0045296|cadherin binding;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;",".","."]
["ENSG00000116983",76,51,86,118.109708699018,146,144,243,0.480182138353324,-1.05834635518481,5.51789332093674e-07,2.76152377722439e-06,"down","yes","HPCAL4","protein_coding","chr1:39678648-39691689:-","gi|635109244|ref|XP_007977495.1|",1358,3e-171,"PREDICTED: hippocalcin-like protein 4 isoform X2 [Chlorocebus sabaeus]","gi|538260574|ref|NM_016257.3|",4856,0,"Homo sapiens hippocalcin like 4 (HPCAL4), transcript variant 1, mRNA","Q5R6S5",396,7e-126,"Hippocalcin-like protein 4","SPAC18B11.04",225,1e-65,"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007165|signal transduction;",".","GO:0005246|calcium channel regulator activity;GO:0005509|calcium ion binding;",".","."]
["ENSG00000150938",9765,9317,8692,15381.7718739904,18385,22485,28138,0.479544270225695,-1.06026408780475,0,0,"down","yes","CRIM1","protein_coding","chr2:36355926-36551135:+","gi|10092639|ref|NP_057525.1|",5197,0,"cysteine-rich motor neuron 1 protein precursor [Homo sapiens]","gi|312261284|ref|NM_016441.2|",5611,0,"Homo sapiens cysteine rich transmembrane BMP regulator 1 (chordin-like) (CRIM1), mRNA","Q9NZV1",2003,0,"Cysteine-rich motor neuron 1 protein",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0007399|nervous system development;GO:0001558|regulation of cell growth;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005520|insulin-like growth factor binding;GO:0005010|insulin-like growth factor-activated receptor activity;GO:0030165|PDZ domain binding;GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSG00000146263",397,357,331,601.226810450306,762,892,1021,0.479478880138653,-1.06046082540052,3.10564355032244e-34,6.18180111440859e-33,"down","yes","MMS22L","protein_coding","chr6:97142161-97283217:-","gi|115583683|ref|NP_940870.2|",6265,0,"protein MMS22-like [Homo sapiens]","gi|115583682|ref|NM_198468.2|",8643,0,"Homo sapiens MMS22 like, DNA repair protein (MMS22L), mRNA","Q6ZRQ5",2419,0,"Protein MMS22-like",".",".",".",".","pfam14910","MMS22L_N","S-phase genomic integrity recombination mediator, N-terminal. MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.","GO:0000724|double-strand break repair via homologous recombination;GO:0031297|replication fork processing;","GO:0005829|cytosol;GO:0043596|nuclear replication fork;GO:0005654|nucleoplasm;",".",".","."]
["ENSG00000106852",28,27,18,40.0879564829006,31,73,81,0.479012072653884,-1.0618660778854,0.00179036385672466,0.00559412571982913,"down","yes","LHX6","protein_coding","chr9:122202577-122229626:-","gi|966990918|ref|XP_014972393.1|",1291,1e-165,"PREDICTED: LIM/homeobox protein Lhx6 isoform X4 [Macaca mulatta]","gi|334191692|ref|NM_001242335.1|",3587,0,"Homo sapiens LIM homeobox 6 (LHX6), transcript variant 5, mRNA","Q9UPM6",503,9e-166,"LIM/homeobox protein Lhx6","ECU03g1170",50.8,7e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0048469|cell maturation;GO:0021853|cerebral cortex GABAergic interneuron migration;GO:0021799|cerebral cortex radially oriented cell migration;GO:0021800|cerebral cortex tangential migration;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09375","LHX6_8; LIM homeobox protein 6/8"]
["ENSG00000182841",73,58,73,113.276006909688,126,189,193,0.478373779309415,-1.06378978038685,5.00483283234177e-08,2.77553811587717e-07,"down","yes","RRP7BP","transcribed_unprocessed_pseudogene","chr22:42555223-42582038:-","gi|694983567|ref|XP_009436804.1|",810,2e-140,"PREDICTED: LOW QUALITY PROTEIN: ribosomal RNA-processing protein 7 homolog A [Pan troglodytes]","gi|21758167|dbj|AK098201.1|",2362,0,"Homo sapiens cDNA FLJ40882 fis, clone UTERU2000424","Q9Y3A4",305,1e-125,"Ribosomal RNA-processing protein 7 homolog A",".",".",".",".","pfam12923","RRP7","Ribosomal RNA-processing protein 7 (RRP7). RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle.","GO:0001825|blastocyst formation;GO:0000028|ribosomal small subunit assembly;GO:0006364|rRNA processing;","GO:0032545|CURI complex;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0034456|UTP-C complex;","GO:0003723|RNA binding;","K14545","RRP7; ribosomal RNA-processing protein 7"]
["ENSG00000179403",258,219,257,407.65636022756,471,593,775,0.477783380724971,-1.06557142309953,5.87622238539096e-24,8.28512992466527e-23,"down","yes","VWA1","protein_coding","chr1:1434861-1442882:+","gi|158256546|dbj|BAF84246.1|",1823,0,"unnamed protein product [Homo sapiens]","gi|262527281|ref|NM_022834.4|",4511,0,"Homo sapiens von Willebrand factor A domain containing 1 (VWA1), transcript variant 1, mRNA","Q6PCB0",704,0,"von Willebrand factor A domain-containing protein 1",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0048266|behavioral response to pain;GO:0044267|cellular protein metabolic process;GO:0030198|extracellular matrix organization;GO:0043687|post-translational protein modification;","GO:0005604|basement membrane;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005614|interstitial matrix;","GO:0042802|identical protein binding;",".","."]
["ENSG00000167767",1167,1136,1110,1896.17258411041,2199,2816,3526,0.477579172070862,-1.0661881749624,8.61922518120481e-94,5.21152399044133e-92,"down","yes","KRT80","protein_coding","chr12:52168996-52192000:-","gi|125628636|ref|NP_872313.2|",2069,0,"keratin, type II cytoskeletal 80 isoform K80 [Homo sapiens]","gi|125628631|ref|NM_001081492.1|",3894,0,"Homo sapiens keratin 80 (KRT80), transcript variant 2, mRNA","Q6KB66",801,0,"Keratin, type II cytoskeletal 80",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0070268|cornification;GO:0031424|keratinization;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0045111|intermediate filament cytoskeleton;GO:0045095|keratin filament;","GO:0005198|structural molecule activity;","K07605","KRT2; type II keratin, basic"]
["ENSG00000066279",1424,1246,1284,2199.98837182473,2758,3182,3898,0.476718091193328,-1.06879171894558,2.85384753362801e-97,1.79299710842401e-95,"down","yes","ASPM","protein_coding","chr1:197084128-197146694:-","gi|126116596|ref|NP_060606.3|",17760,0,"abnormal spindle-like microcephaly-associated protein isoform 1 [Homo sapiens]","gi|194248058|ref|NM_018136.4|",10887,0,"Homo sapiens abnormal spindle microtubule assembly (ASPM), transcript variant 1, mRNA","Q8IZT6",6844,0,"Abnormal spindle-like microcephaly-associated protein",".",".",".",".","pfam11971","CAMSAP_CH","CAMSAP CH domain. This domain is the N-terminal CH domain from the CAMSAP proteins.i","GO:0021987|cerebral cortex development;GO:0048589|developmental growth;GO:0021873|forebrain neuroblast division;GO:0051661|maintenance of centrosome location;GO:0008584|male gonad development;GO:0045769|negative regulation of asymmetric cell division;GO:0045665|negative regulation of neuron differentiation;GO:0001764|neuron migration;GO:0097150|neuronal stem cell population maintenance;GO:0048477|oogenesis;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0002052|positive regulation of neuroblast proliferation;GO:0051445|regulation of meiotic cell cycle;GO:0007283|spermatogenesis;GO:0090306|spindle assembly involved in meiosis;GO:0051653|spindle localization;GO:0007051|spindle organization;","GO:0016324|apical plasma membrane;GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0072687|meiotic spindle;GO:0036449|microtubule minus-end;GO:0030496|midbody;GO:0097431|mitotic spindle pole;GO:0005634|nucleus;","GO:0005516|calmodulin binding;GO:0019901|protein kinase binding;","K16743","ASPM, ASP; abnormal spindle-like microcephaly-associated protein"]
["ENSG00000131462",1014,946,830,1550.62164345889,1889,2297,2766,0.476522997905965,-1.06938225186603,7.28833437645985e-81,3.54993417811004e-79,"down","yes","TUBG1","protein_coding","chr17:42609676-42615234:+","gi|31543831|ref|NP_001061.2|",2347,0,"tubulin gamma-1 chain [Homo sapiens]","gi|222352112|ref|NM_001070.4|",1611,0,"Homo sapiens tubulin gamma 1 (TUBG1), mRNA","P23258",908,0,"Tubulin gamma-1 chain","SPBC32F12.04",643,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0071277|cellular response to calcium ion;GO:0031122|cytoplasmic microtubule organization;GO:0000086|G2/M transition of mitotic cell cycle;GO:0000212|meiotic spindle organization;GO:0000226|microtubule cytoskeleton organization;GO:0007020|microtubule nucleation;GO:0010389|regulation of G2/M transition of mitotic cell cycle;","GO:0045177|apical part of cell;GO:0031252|cell leading edge;GO:0005814|centriole;GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0000794|condensed nuclear chromosome;GO:0005737|cytoplasm;GO:0005881|cytoplasmic microtubule;GO:0005829|cytosol;GO:0000930|gamma-tubulin complex;GO:0000242|pericentriolar material;GO:0005827|polar microtubule;GO:0055037|recycling endosome;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0042802|identical protein binding;GO:0005200|structural constituent of cytoskeleton;","K10389","TUBG; tubulin gamma"]
["ENSG00000215883",52,44,43,77.1464218633432,86,122,140,0.476520914573761,-1.06938855926278,2.46870274241503e-06,1.15265888394338e-05,"down","yes","CYB5RL","protein_coding","chr1:54169651-54200036:-","gi|675730797|ref|XP_008966111.1|",982,2e-117,"PREDICTED: NADH-cytochrome b5 reductase-like isoform X2 [Pan paniscus]","gi|20330128|emb|AL357673.12|",5176,0,"Human DNA sequence from clone RP11-446E24 on chromosome 1, complete sequence","Q6IPT4",323,2e-97,"NADH-cytochrome b5 reductase-like","YIL043c",73.2,1e-12,"COG0543","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0015701|bicarbonate transport;","GO:0005789|endoplasmic reticulum membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0004128|cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0016491|oxidoreductase activity;","K00326","E1.6.2.2; cytochrome-b5 reductase [EC:1.6.2.2]"]
["ENSG00000182809",163,173,165,279.637449046739,366,382,500,0.476280383094756,-1.07011696628775,2.01514334388184e-17,2.11239591395613e-16,"down","yes","CRIP2","protein_coding","chr14:105472962-105480170:+","gi|724892235|ref|XP_010375210.1|",1019,8e-132,"PREDICTED: cysteine-rich protein 2 isoform X4 [Rhinopithecus roxellana]","gi|399498573|ref|NR_073084.1|",1976,0,"Homo sapiens cysteine rich protein 2 (CRIP2), transcript variant 7, non-coding RNA","P52943",397,4e-133,"Cysteine-rich protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0030097|hemopoiesis;GO:0008284|positive regulation of cell proliferation;","GO:0005938|cell cortex;","GO:0008270|zinc ion binding;",".","."]
["ENSG00000040275",1299,1193,1200,2054.57013137288,2426,3041,3780,0.476240634901731,-1.07023737207389,9.36773998874893e-107,6.6920358852959e-105,"down","yes","SPDL1","protein_coding","chr5:169583634-169604778:+","gi|157388975|ref|NP_060255.3|",2788,0,"protein Spindly [Homo sapiens]","gi|157388974|ref|NM_017785.4|",2668,0,"Homo sapiens spindle apparatus coiled-coil protein 1 (SPDL1), mRNA","Q96EA4",1078,0,"Protein Spindly",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0051301|cell division;GO:0000132|establishment of mitotic spindle orientation;GO:0007080|mitotic metaphase plate congression;GO:0034501|protein localization to kinetochore;GO:0031577|spindle checkpoint;","GO:0000940|condensed chromosome outer kinetochore;GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0019899|enzyme binding;GO:0043515|kinetochore binding;",".","."]
["ENSG00000095002",1084,1020,1008,1734.74035936034,2168,2535,3057,0.475881633602916,-1.07132531935787,2.40502263437341e-87,1.32537361633698e-85,"down","yes","MSH2","protein_coding","chr2:47402969-47663146:+","gi|767914587|ref|XP_011531169.1|",4770,0,"PREDICTED: DNA mismatch repair protein Msh2 isoform X2 [Homo sapiens]","gi|767914586|ref|XM_011532867.1|",5315,0,"PREDICTED: Homo sapiens mutS homolog 2 (MSH2), transcript variant X2, mRNA","P43246",1762,0,"DNA mismatch repair protein Msh2","YOL090w",680,0,"COG0249","pfam00488","MutS_V","MutS domain V. This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam01624, pfam05188, pfam05192 and pfam05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterized in, which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.","GO:0030183|B cell differentiation;GO:0019724|B cell mediated immunity;GO:0007050|cell cycle arrest;GO:0008340|determination of adult lifespan;GO:0006281|DNA repair;GO:0006302|double-strand break repair;GO:0007281|germ cell development;GO:0001701|in utero embryonic development;GO:0031573|intra-S DNA damage checkpoint;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045190|isotype switching;GO:0043570|maintenance of DNA repeat elements;GO:0008584|male gonad development;GO:0006311|meiotic gene conversion;GO:0006298|mismatch repair;GO:0045910|negative regulation of DNA recombination;GO:0043524|negative regulation of neuron apoptotic process;GO:0045128|negative regulation of reciprocal meiotic recombination;GO:0006119|oxidative phosphorylation;GO:0051096|positive regulation of helicase activity;GO:0048298|positive regulation of isotype switching to IgA isotypes;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0006301|postreplication repair;GO:0010224|response to UV-B;GO:0010165|response to X-ray;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0016447|somatic recombination of immunoglobulin gene segments;","GO:0016020|membrane;GO:0032301|MutSalpha complex;GO:0032302|MutSbeta complex;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0019237|centromeric DNA binding;GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0008094|DNA-dependent ATPase activity;GO:0000406|double-strand/single-strand DNA junction binding;GO:0019899|enzyme binding;GO:0032137|guanine/thymine mispair binding;GO:0000404|heteroduplex DNA loop binding;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0000403|Y-form DNA binding;","K08735","MSH2; DNA mismatch repair protein MSH2"]
["ENSG00000138376",399,363,360,624.417473072975,730,915,1172,0.475667683112469,-1.07197408303484,1.02039130726782e-38,2.2938586870142e-37,"down","yes","BARD1","protein_coding","chr2:214725646-214809711:-","gi|1710175|gb|AAB38316.1|",3866,0,"BRCA1-associated RING domain protein [Homo sapiens]","gi|543583785|ref|NM_000465.3|",5499,0,"Homo sapiens BRCA1 associated RING domain 1 (BARD1), transcript variant 1, mRNA","Q99728",1490,0,"BRCA1-associated RING domain protein 1","PAE1861",81.6,1e-15,"COG0666","pfam14835","zf-RING_6","zf-RING of BARD1-type protein. The RING domain of the breast and ovarian cancer tumor-suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. A dimer is formed between the RING domains of BRCA1 and BARD1. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level. The corresponding BRCA1-RING domain is on family zf-C3HC4_2, pfam13923.","GO:0007050|cell cycle arrest;GO:0006974|cellular response to DNA damage stimulus;GO:0000729|DNA double-strand break processing;GO:0006260|DNA replication;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0043066|negative regulation of apoptotic process;GO:0031441|negative regulation of mRNA 3'-end processing;GO:0046826|negative regulation of protein export from nucleus;GO:0043065|positive regulation of apoptotic process;GO:0045732|positive regulation of protein catabolic process;GO:0016579|protein deubiquitination;GO:0085020|protein K6-linked ubiquitination;GO:0016567|protein ubiquitination;GO:0042325|regulation of phosphorylation;GO:0001894|tissue homeostasis;","GO:0070531|BRCA1-A complex;GO:0031436|BRCA1-BARD1 complex;GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0019900|kinase binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0003723|RNA binding;GO:0004842|ubiquitin-protein transferase activity;","K10683","BARD1; BRCA1-associated RING domain protein 1"]
["ENSG00000122547",51,61,71,102.359948881445,114,149,201,0.475568994721609,-1.07227343493309,2.73076363177942e-07,1.40643441735011e-06,"down","yes","EEPD1","protein_coding","chr7:36153149-36301543:+","gi|71043966|ref|NP_085139.2|",2960,0,"endonuclease/exonuclease/phosphatase family domain-containing protein 1 [Homo sapiens]","gi|71043965|ref|NM_030636.2|",4687,0,"Homo sapiens endonuclease/exonuclease/phosphatase family domain containing 1 (EEPD1), mRNA","Q7L9B9",1144,0,"Endonuclease/exonuclease/phosphatase family domain-containing protein 1","TM1052",87.4,6e-18,"COG1555","pfam12836","HHH_3","Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.","GO:0006281|DNA repair;",".","GO:0003677|DNA binding;",".","."]
["ENSG00000169607",508,489,542,859.954953026046,1042,1253,1569,0.475071714537306,-1.07378278271144,1.20765419220253e-44,3.14773433232466e-43,"down","yes","CKAP2L","protein_coding","chr2:112736607-112764677:-","gi|167466272|ref|NP_689728.3|",3628,0,"cytoskeleton-associated protein 2-like isoform 1 [Homo sapiens]","gi|748821156|ref|NM_152515.4|",4533,0,"Homo sapiens cytoskeleton associated protein 2 like (CKAP2L), transcript variant 1, mRNA","Q8IYA6",1401,0,"Cytoskeleton-associated protein 2-like",".",".",".",".","pfam15297","CKAP2_C","Cytoskeleton-associated protein 2 C-terminus. This family includes the C-terminus of CKAP2 and CKAP2L. CKAP2 is a microtubule associated protein which stabilizes microtubules.",".","GO:0005813|centrosome;GO:0005829|cytosol;GO:0072686|mitotic spindle;GO:0000922|spindle pole;",".","K16769","CKAP2; cytoskeleton-associated protein 2"]
["ENSG00000213347",240,198,195,352.368246064423,428,515,641,0.475029028451821,-1.07391241739353,4.23606234516877e-23,5.77013916056605e-22,"down","yes","MXD3","protein_coding","chr5:177301461-177312757:-","gi|72534833|ref|NP_001026847.1|",993,1e-126,"ras-related protein Rab-24 [Homo sapiens]","gi|27469583|gb|BC041690.1|",1350,0,"Homo sapiens MAX dimerization protein 3, mRNA (cDNA clone IMAGE:5240341), with apparent retained intron","Q969Q5",387,4e-128,"Ras-related protein Rab-24",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006914|autophagy;GO:0043312|neutrophil degranulation;GO:0015031|protein transport;","GO:0005776|autophagosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07912","RAB24; Ras-related protein Rab-24"]
["ENSG00000180914",13,22,10,25.1310792472341,32,38,42,0.474927095969968,-1.07422202640148,0.00898103178226439,0.0241293956656536,"down","yes","OXTR","protein_coding","chr3:8750408-8769628:-","gi|426339284|ref|XP_004033584.1|",1559,0,"PREDICTED: oxytocin receptor [Gorilla gorilla gorilla]","gi|32307151|ref|NM_000916.3|",4361,0,"Homo sapiens oxytocin receptor (OXTR), mRNA","P30559",603,0,"Oxytocin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007166|cell surface receptor signaling pathway;GO:0032870|cellular response to hormone stimulus;GO:0048565|digestive tract development;GO:0042755|eating behavior;GO:0070371|ERK1 and ERK2 cascade;GO:0044849|estrous cycle;GO:0007565|female pregnancy;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007507|heart development;GO:0007595|lactation;GO:0042711|maternal behavior;GO:0060137|maternal process involved in parturition;GO:0007613|memory;GO:0006936|muscle contraction;GO:0060455|negative regulation of gastric acid secretion;GO:0045777|positive regulation of blood pressure;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010701|positive regulation of norepinephrine secretion;GO:0060406|positive regulation of penile erection;GO:0051965|positive regulation of synapse assembly;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0045907|positive regulation of vasoconstriction;GO:0001992|regulation of systemic arterial blood pressure by vasopressin;GO:0001975|response to amphetamine;GO:0034059|response to anoxia;GO:0042220|response to cocaine;GO:0034097|response to cytokine;GO:0032355|response to estradiol;GO:1901652|response to peptide;GO:0043434|response to peptide hormone;GO:0032570|response to progesterone;GO:0030431|sleep;GO:0035176|social behavior;GO:0042713|sperm ejaculation;GO:0001967|suckling behavior;GO:0021537|telencephalon development;","GO:0016324|apical plasma membrane;GO:0005913|cell-cell adherens junction;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005902|microvillus;GO:0005886|plasma membrane;","GO:0004990|oxytocin receptor activity;GO:0042277|peptide binding;GO:0017046|peptide hormone binding;GO:0005000|vasopressin receptor activity;","K04229","OXTR; oxytocin receptor"]
["ENSG00000206417",26,21,11,32.1164024761585,39,55,49,0.474850127148707,-1.07445585499681,0.00358148740755583,0.0105096195218221,"down","yes","H1FX-AS1","antisense","chr3:129315392-129326225:+","gi|635122794|ref|XP_007984414.1|",326,9e-71,"PREDICTED: uncharacterized protein LOC103228658 [Chlorocebus sabaeus]","gi|551850675|tpe|HG496047.1|",2600,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000355523.2 (RP13-685P2.5 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000138336",34,31,29,52.7267197115915,80,80,69,0.474540577430334,-1.07539663913821,0.00026013162572309,0.00093672355448573,"down","yes","TET1","protein_coding","chr10:68560656-68694482:+","gi|119574684|gb|EAW54299.1|",10260,0,"CXXC finger 6, partial [Homo sapiens]","gi|156139121|ref|NM_030625.2|",9288,0,"Homo sapiens tet methylcytosine dioxygenase 1 (TET1), mRNA","Q8NFU7",3921,0,"Methylcytosine dioxygenase TET1",".",".",".",".","pfam12851","Tet_JBP","Oxygenase domain of the 2OGFeDO superfamily. A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.","GO:0006325|chromatin organization;GO:0080111|DNA demethylation;GO:0001826|inner cell mass cell differentiation;GO:0090310|negative regulation of methylation-dependent chromatin silencing;GO:0008284|positive regulation of cell proliferation;GO:0031062|positive regulation of histone methylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006493|protein O-linked glycosylation;GO:0019827|stem cell population maintenance;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0005506|iron ion binding;GO:0070579|methylcytosine dioxygenase activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008270|zinc ion binding;","K13097","TET1; methylcytosine dioxygenase [EC:1.14.11.-]"]
["ENSG00000160014",3210,3187,3028,5262.21895229197,6416,7510,9753,0.474534819669097,-1.07541414395102,7.74299242668399e-170,1.07443768292001e-167,"down","yes","CALM3","protein_coding","chr19:46601074-46610793:+","gi|426389328|ref|XP_004061075.1|",895,2e-111,"PREDICTED: uncharacterized protein LOC101150587 [Gorilla gorilla gorilla]","gi|21754132|dbj|AK094964.1|",2527,0,"Homo sapiens cDNA FLJ37645 fis, clone BRHIP2000245","P05419",170,1e-47,"Neo-calmodulin (Fragment)","SPAC3A12.14",148,5e-40,"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;","K02183","CALM; calmodulin"]
["ENSG00000177359",49,29,33,61.6543885689521,75,88,115,0.474036328457758,-1.0769304685117,3.5937025097818e-05,0.000145804236450718,"down","yes","AC024940.1","transcribed_unprocessed_pseudogene","chr12:31111652-31201235:-","gi|767972704|ref|XP_011519204.1|",5812,0,"PREDICTED: ovostatin homolog 2 isoform X4 [Homo sapiens]","gi|767972703|ref|XM_011520902.1|",3529,0,"PREDICTED: Homo sapiens ovostatin 2 (OVOS2), transcript variant X25, mRNA","Q6IE36",2206,0,"Ovostatin homolog 2",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSG00000184992",672,602,537,1010.51622714923,1310,1438,1767,0.473986309165335,-1.07708270661727,8.61727248962161e-50,2.48445368878657e-48,"down","yes","BRI3BP","protein_coding","chr12:124993700-125031231:+","gi|795292184|ref|XP_011759702.1|",816,5e-95,"PREDICTED: BRI3-binding protein [Macaca nemestrina]","gi|25815267|gb|AC122688.5|",6242,0,"Homo sapiens 12 BAC RP11-158L12 (Roswell Park Cancer Institute Human BAC Library) complete sequence","Q8WY22",318,2e-96,"BRI3-binding protein",".",".",".",".","pfam14965","BRI3BP","Negative regulator of p53/TP53. This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumorigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumor suppressor. BRI3BP induces tumorigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumors.",".","GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;",".",".","."]
["ENSG00000197744",14,20,15,27.4394317628919,36,31,57,0.473517067116331,-1.07851166877058,0.00580793509208485,0.0163014336519401,"down","yes","PTMAP2","processed_pseudogene","chr5:118973796-118974122:+",".",".",".",".","gi|172088140|ref|NG_002765.3|",327,1e-169,"Homo sapiens prothymosin, alpha pseudogene 2 (PTMAP2) on chromosome 5",".",".",".",".",".",".",".",".","pfam03247","Prothymosin","Prothymosin/parathymosin family. Prothymosin alpha and parathymosin are two ubiquitous small acidic nuclear proteins that are thought to be involved in cell cycle progression, proliferation, and cell differentiation.",".",".",".",".","."]
["ENSG00000130005",465,503,415,772.871416582472,945,1053,1493,0.47322197362215,-1.07941102945208,1.30665535586548e-37,2.83495708705661e-36,"down","yes","GAMT","protein_coding","chr19:1397026-1401570:-","gi|20336212|ref|NP_620279.1|",1338,8e-180,"guanidinoacetate N-methyltransferase isoform b [Homo sapiens]","gi|375268697|ref|NM_138924.2|",1769,0,"Homo sapiens guanidinoacetate N-methyltransferase (GAMT), transcript variant 2, mRNA","Q14353",363,9e-121,"Guanidinoacetate N-methyltransferase",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0009887|organ morphogenesis;GO:0006601|creatine biosynthetic process;GO:0006600|creatine metabolic process;GO:0006936|muscle contraction;GO:0040014|regulation of multicellular organism growth;GO:0046498|S-adenosylhomocysteine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0030731|guanidinoacetate N-methyltransferase activity;GO:0008168|methyltransferase activity;","K00542","GAMT; guanidinoacetate N-methyltransferase [EC:2.1.1.2]"]
["ENSG00000145040",36,41,40,65.6602147757264,86,88,120,0.473204809290678,-1.07946335868947,1.47236238097053e-05,6.30107069096065e-05,"down","yes","UCN2","protein_coding","chr3:48561727-48563773:-","gi|955483478|ref|XP_014647219.1|",320,4e-28,"PREDICTED: collagen alpha-1(VII) chain isoform X2 [Ceratotherium simum simum]","gi|63053518|ref|NM_033199.3|",1476,0,"Homo sapiens urocortin 2 (UCN2), mRNA","Q96RP3",97.1,2e-22,"Urocortin-2",".",".",".",".","pfam11613","UCN2","Agonist of corticotropin releasing factor R2, Urocortin-2. This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif.","GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0031669|cellular response to nutrient levels;GO:0007586|digestion;GO:0009755|hormone-mediated signaling pathway;GO:0006950|response to stress;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005622|intracellular;","GO:0051431|corticotropin-releasing hormone receptor 2 binding;GO:0051429|corticotropin-releasing hormone receptor binding;GO:0001664|G-protein coupled receptor binding;GO:0005179|hormone activity;GO:0042562|hormone binding;","K05257","UCN2_3; urocortin 2/3"]
["ENSG00000117983",169,141,118,238.660631217729,284,347,448,0.472102916516912,-1.08282669936022,6.82600478847232e-16,6.62606846301229e-15,"down","yes","MUC5B","protein_coding","chr11:1223066-1262172:+","gi|301172750|ref|NP_002449.2|",9468,0,"mucin-5B precursor [Homo sapiens]","gi|301172749|ref|NM_002458.2|",17911,0,"Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA","Q9HC84",3537,0,"Mucin-5B",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0016266|O-glycan processing;GO:0002223|stimulatory C-type lectin receptor signaling pathway;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005796|Golgi lumen;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;",".","K13908","MUC5B, MG1; mucin-5B"]
["ENSG00000120913",82,86,73,134.76821350145,154,195,263,0.471823221258053,-1.08368167086398,4.64331217870426e-10,3.09682590950373e-09,"down","yes","PDLIM2","protein_coding","chr8:22578279-22598025:+","gi|21748552|dbj|BAC03413.1|",575,4e-64,"FLJ00349 protein [Homo sapiens]","gi|354721125|ref|NG_030435.1|",6559,0,"Homo sapiens PDZ and LIM domain 2 (PDLIM2), RefSeqGene on chromosome 8","Q96JY6",131,1e-30,"PDZ and LIM domain protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005634|nucleus;","GO:0046872|metal ion binding;",".","."]
["ENSG00000117519",4524,4217,4074,7182.29388158987,8586,10617,13211,0.471207897159018,-1.08556437682111,1.05014312165913e-275,3.21510484612083e-273,"down","yes","CNN3","protein_coding","chr1:94896949-94927278:-","gi|281349702|gb|EFB25286.1|",1832,0,"hypothetical protein PANDA_003128, partial [Ailuropoda melanoleuca]","gi|426330433|ref|XM_004026169.1|",2116,0,"PREDICTED: Gorilla gorilla gorilla calponin 3, acidic, transcript variant 1 (CNN3), mRNA","Q15417",690,0,"Calponin-3","ECU03g1150",74.3,5e-14,"COG5199","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0031032|actomyosin structure organization;GO:0030855|epithelial cell differentiation;GO:0032780|negative regulation of ATPase activity;","GO:0015629|actin cytoskeleton;GO:0005913|cell-cell adherens junction;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0005925|focal adhesion;GO:0043025|neuronal cell body;GO:0014069|postsynaptic density;","GO:0003779|actin binding;GO:0098641|cadherin binding involved in cell-cell adhesion;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;",".","."]
["ENSG00000113810",2362,2128,2171,3737.33941625756,4586,5625,6580,0.470951165833509,-1.08635062414148,1.3309552538734e-150,1.54647379136808e-148,"down","yes","SMC4","protein_coding","chr3:160399274-160434962:+","gi|50658063|ref|NP_001002800.1|",6035,0,"structural maintenance of chromosomes protein 4 isoform 1 [Homo sapiens]","gi|570700830|ref|NM_001002800.2|",5471,0,"Homo sapiens structural maintenance of chromosomes 4 (SMC4), transcript variant 2, mRNA","Q9NTJ3",2329,0,"Structural maintenance of chromosomes protein 4","SPBC146.03c",495,3e-147,"COG1196","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0051301|cell division;GO:0051383|kinetochore organization;GO:0010032|meiotic chromosome condensation;GO:0045132|meiotic chromosome segregation;GO:0007076|mitotic chromosome condensation;GO:0000070|mitotic sister chromatid segregation;","GO:0000796|condensin complex;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046982|protein heterodimerization activity;","K06675","SMC4; structural maintenance of chromosome 4"]
["ENSG00000126259",62,38,59,89.0544139764702,102,123,181,0.470451424402736,-1.0878823270688,1.44970653537655e-06,6.93156659750689e-06,"down","yes","KIRREL2","protein_coding","chr19:35855861-35867109:+","gi|441627319|ref|XP_004089244.1|",3218,0,"PREDICTED: kin of IRRE-like protein 2 isoform X1 [Nomascus leucogenys]","gi|612407795|ref|NM_199180.3|",2942,0,"Homo sapiens kin of IRRE like 2 (Drosophila) (KIRREL2), transcript variant 3, mRNA","Q6UWL6",1230,0,"Kin of IRRE-like protein 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0098609|cell-cell adhesion;GO:0001933|negative regulation of protein phosphorylation;","GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0036057|slit diaphragm;","GO:0042802|identical protein binding;",".","."]
["ENSG00000152284",107,97,88,163.449474193205,185,247,310,0.470408772910937,-1.08801312885194,4.42322548972132e-12,3.42768876037544e-11,"down","yes","TCF7L1","protein_coding","chr2:85133410-85310388:+","gi|13786123|ref|NP_112573.1|",1951,0,"transcription factor 7-like 1 [Homo sapiens]","gi|312433971|ref|NM_031283.2|",2918,0,"Homo sapiens transcription factor 7 like 1 (TCF7L1), mRNA","Q9HCS4",756,0,"Transcription factor 7-like 1",".",".",".",".","pfam08347","CTNNB1_binding","N-terminal CTNNB1 binding. This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.","GO:0060070|canonical Wnt signaling pathway;GO:0006325|chromatin organization;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;GO:0030111|regulation of Wnt signaling pathway;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0008013|beta-catenin binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;","K04490","TCF7L1; transcription factor 7-like 1"]
["ENSG00000249115",401,380,419,675.22729754098,849,944,1247,0.470194239994319,-1.08867122918977,7.91026215080047e-37,1.68217349905887e-35,"down","yes","HAUS5","protein_coding","chr19:35612744-35625349:+","gi|149944680|ref|NP_056117.1|",2377,0,"HAUS augmin-like complex subunit 5 [Homo sapiens]","gi|149944679|ref|NM_015302.1|",4042,0,"Homo sapiens HAUS augmin like complex subunit 5 (HAUS5), mRNA","O94927",920,0,"HAUS augmin-like complex subunit 5",".",".",".",".","pfam14817","HAUS5","HAUS augmin-like complex subunit 5. This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.","GO:0051301|cell division;GO:0007098|centrosome cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0070652|HAUS complex;GO:0005874|microtubule;GO:0005819|spindle;",".","K16588","HAUS5; HAUS augmin-like complex subunit 5"]
["ENSG00000156463",361,380,310,590.403283422971,723,903,1027,0.46994161908747,-1.08944655317042,1.1896465936759e-34,2.39269066723886e-33,"down","yes","SH3RF2","protein_coding","chr5:145936579-146081791:+","gi|578810801|ref|XP_006714820.1|",3486,0,"PREDICTED: putative E3 ubiquitin-protein ligase SH3RF2 isoform X1 [Homo sapiens]","gi|578810800|ref|XM_006714757.1|",5589,0,"PREDICTED: Homo sapiens SH3 domain containing ring finger 2 (SH3RF2), transcript variant X5, mRNA","Q8TEC5",1298,0,"Putative E3 ubiquitin-protein ligase SH3RF2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0010923|negative regulation of phosphatase activity;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;","GO:0046872|metal ion binding;GO:0019902|phosphatase binding;GO:0008157|protein phosphatase 1 binding;GO:0004864|protein phosphatase inhibitor activity;GO:0016740|transferase activity;","K12171","SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"]
["ENSG00000132383",1882,1953,1731,3126.84004399626,3722,4587,5832,0.469871280788365,-1.08966250405917,2.77028689599205e-126,2.55661692104759e-124,"down","yes","RPA1","protein_coding","chr17:1829702-1900082:+","gi|4506583|ref|NP_002936.1|",3178,0,"replication protein A 70 kDa DNA-binding subunit [Homo sapiens]","gi|182765449|ref|NM_002945.3|",4340,0,"Homo sapiens replication protein A1 (RPA1), mRNA","P27694",1226,0,"Replication protein A 70 kDa DNA-binding subunit","SPBC660.13c",422,2e-130,"COG1599","pfam08646","Rep_fac-A_C","Replication factor-A C terminal domain. This domain is found at the C terminal of replication factor A. Replication factor A (RPA) binds single-stranded DNA and is involved in replication, repair, and recombination of DNA.","GO:0006284|base-excision repair;GO:0042769|DNA damage response, detection of DNA damage;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0006261|DNA-dependent DNA replication;GO:0000724|double-strand break repair via homologous recombination;GO:0070987|error-free translesion synthesis;GO:0042276|error-prone translesion synthesis;GO:0000082|G1/S transition of mitotic cell cycle;GO:0036297|interstrand cross-link repair;GO:0006298|mismatch repair;GO:0006289|nucleotide-excision repair;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294|nucleotide-excision repair, preincision complex assembly;GO:0006293|nucleotide-excision repair, preincision complex stabilization;GO:0034502|protein localization to chromosome;GO:1900034|regulation of cellular response to heat;GO:0000723|telomere maintenance;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0005662|DNA replication factor A complex;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;","GO:0003684|damaged DNA binding;GO:0098505|G-rich strand telomeric DNA binding;GO:0046872|metal ion binding;GO:0003697|single-stranded DNA binding;","K07466","RFA1, RPA1, rpa; replication factor A1"]
["ENSG00000127191",692,629,574,1063.83078414036,1317,1593,1872,0.469857004319345,-1.08970633926427,1.53297501142994e-61,5.45535461632118e-60,"down","yes","TRAF2","protein_coding","chr9:136881912-136926607:+","gi|530426780|ref|XP_005266156.1|",2733,0,"PREDICTED: TNF receptor-associated factor 2 isoform X3 [Homo sapiens]","gi|42544228|ref|NM_021138.3|",2264,0,"Homo sapiens TNF receptor associated factor 2 (TRAF2), mRNA","Q12933",1038,0,"TNF receptor-associated factor 2",".",".",".",".","pfam00917","MATH","MATH domain. This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0034622|cellular macromolecular complex assembly;GO:0071732|cellular response to nitric oxide;GO:0071550|death-inducing signaling complex assembly;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0034351|negative regulation of glial cell apoptotic process;GO:1901215|negative regulation of neuron death;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:0032743|positive regulation of interleukin-2 production;GO:0043507|positive regulation of JUN kinase activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0090073|positive regulation of protein homodimerization activity;GO:0002726|positive regulation of T cell cytokine production;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0097300|programmed necrotic cell death;GO:0051865|protein autoubiquitination;GO:0030163|protein catabolic process;GO:0016579|protein deubiquitination;GO:0051291|protein heterooligomerization;GO:0070207|protein homotrimerization;GO:0070534|protein K63-linked ubiquitination;GO:0065003|macromolecular complex assembly;GO:0042981|regulation of apoptotic process;GO:1902041|regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0051023|regulation of immunoglobulin secretion;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0034976|response to endoplasmic reticulum stress;GO:0007165|signal transduction;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:1990597|AIP1-IRE1 complex;GO:0035631|CD40 receptor complex;GO:0005938|cell cortex;GO:0009898|cytoplasmic side of plasma membrane;GO:0005829|cytosol;GO:1990604|IRE1-TRAF2-ASK1 complex;GO:0045121|membrane raft;GO:0005654|nucleoplasm;GO:0097057|TRAF2-GSTP1 complex;GO:0000151|ubiquitin ligase complex;GO:0012506|vesicle membrane;","GO:0005174|CD40 receptor binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0031435|mitogen-activated protein kinase kinase kinase binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0044877|macromolecular complex binding;GO:0046625|sphingolipid binding;GO:0031996|thioesterase binding;GO:0005164|tumor necrosis factor receptor binding;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K03173","TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]"]
["ENSG00000130816",5220,5239,4743,8542.86136448794,10229,12646,15717,0.469624692269758,-1.09041982937254,1.50912324246618e-242,3.63849613758596e-240,"down","yes","DNMT1","protein_coding","chr19:10133345-10231286:-","gi|119604485|gb|EAW84079.1|",8107,0,"DNA (cytosine-5-)-methyltransferase 1, isoform CRA_a [Homo sapiens]","gi|973353109|ref|NM_001379.3|",5408,0,"Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA","P26358",3035,0,"DNA (cytosine-5)-methyltransferase 1","HP0051",130,5e-31,"COG0270","pfam12047","DNMT1-RFD","Cytosine specific DNA methyltransferase replication foci domain. This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties.","GO:0071230|cellular response to amino acid stimulus;GO:0006325|chromatin organization;GO:0006306|DNA methylation;GO:0043045|DNA methylation involved in embryo development;GO:0016458|gene silencing;GO:0010216|maintenance of DNA methylation;GO:0010629|negative regulation of gene expression;GO:0045814|negative regulation of gene expression, epigenetic;GO:0051573|negative regulation of histone H3-K9 methylation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0010628|positive regulation of gene expression;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0090309|positive regulation of methylation-dependent chromatin silencing;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0007265|Ras protein signal transduction;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005721|pericentric heterochromatin;GO:0005657|replication fork;","GO:0003886|DNA (cytosine-5-)-methyltransferase activity;GO:0003677|DNA binding;GO:0009008|DNA-methyltransferase activity;GO:0008327|methyl-CpG binding;GO:1990841|promoter-specific chromatin binding;GO:0003723|RNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008270|zinc ion binding;","K00558","DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"]
["ENSG00000166965",574,542,536,929.144244881275,1156,1341,1687,0.46949937420896,-1.09080485996088,6.25207854636686e-56,2.0473699660836e-54,"down","yes","RCCD1","protein_coding","chr15:90954870-90963125:+","gi|119622536|gb|EAX02131.1|",1333,4e-171,"RCC1 domain containing 1, isoform CRA_b, partial [Homo sapiens]","gi|66267189|gb|BC094739.1|",3126,0,"Homo sapiens cDNA clone IMAGE:5269312","A6NED2",421,9e-136,"RCC1 domain-containing protein 1",".",".",".",".","pfam13540","RCC1_2","Regulator of chromosome condensation (RCC1) repeat.","GO:0006325|chromatin organization;","GO:0005694|chromosome;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000062038",26,30,22,43.9051024402371,52,69,77,0.468301521371088,-1.09449036995959,0.000282742943265932,0.00101258508438079,"down","yes","CDH3","protein_coding","chr16:68636189-68722616:+","gi|14589891|ref|NP_001784.2|",3957,0,"cadherin-3 isoform 1 preproprotein [Homo sapiens]","gi|953953833|ref|NM_001793.5|",3702,0,"Homo sapiens cadherin 3 (CDH3), transcript variant 1, mRNA","P22223",1521,0,"Cadherin-3",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0034332|adherens junction organization;GO:0060070|canonical Wnt signaling pathway;GO:0007155|cell adhesion;GO:0022405|hair cycle process;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424|keratinization;GO:0051796|negative regulation of catagen;GO:0032912|negative regulation of transforming growth factor beta2 production;GO:0010628|positive regulation of gene expression;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0010838|positive regulation of keratinocyte proliferation;GO:0048023|positive regulation of melanin biosynthetic process;GO:1902910|positive regulation of melanosome transport;GO:0032773|positive regulation of monophenol monooxygenase activity;GO:0060901|regulation of hair cycle by canonical Wnt signaling pathway;GO:0042493|response to drug;GO:0001895|retina homeostasis;GO:0007601|visual perception;GO:0042060|wound healing;","GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K06796","CDH3; cadherin 3, type 1, P-cadherin"]
["ENSG00000143502",31,36,20,48.9613826769844,69,62,88,0.467945777985026,-1.09558672397621,0.000246999635833206,0.000891658052770145,"down","yes","SUSD4","protein_coding","chr1:223220819-223364202:-","gi|148539593|ref|NP_060452.3|",2330,0,"sushi domain-containing protein 4 isoform a precursor [Homo sapiens]","gi|21755715|dbj|AK096265.1|",3274,0,"Homo sapiens cDNA FLJ38946 fis, clone NT2NE2017752, highly similar to Homo sapiens sushi domain containing 4 (SUSD4), transcript variant 1, mRNA","Q5VX71",902,0,"Sushi domain-containing protein 4",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;GO:0045957|negative regulation of complement activation, alternative pathway;GO:0045959|negative regulation of complement activation, classical pathway;GO:0030449|regulation of complement activation;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000138395",101,98,113,176.306287586928,208,278,309,0.467681413353598,-1.09640200073693,1.79367426247559e-12,1.42724377783124e-11,"down","yes","CDK15","protein_coding","chr2:201790461-201895550:+","gi|387598035|ref|NP_001248364.1|",2310,0,"cyclin-dependent kinase 15 isoform 1 [Homo sapiens]","gi|387598034|ref|NM_001261435.1|",3659,0,"Homo sapiens cyclin-dependent kinase 15 (CDK15), transcript variant 1, mRNA","Q96Q40",888,0,"Cyclin-dependent kinase 15",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0030332|cyclin binding;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;","K15594","CDK15, PFTK2; cyclin-dependent kinase 15 [EC:2.7.11.22]"]
["ENSG00000171951",19,20,7,25.5128400379763,21,34,66,0.467282024400695,-1.09763455481021,0.0128180883176943,0.0332872591727888,"down","yes","SCG2","protein_coding","chr2:223596940-223602503:-","gi|795610663|ref|XP_011918103.1|",3166,0,"PREDICTED: secretogranin-2 [Cercocebus atys]","gi|305682581|ref|NM_003469.4|",2572,0,"Homo sapiens secretogranin II (SCG2), mRNA","P13521",1217,0,"Secretogranin-2",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).","GO:0001525|angiogenesis;GO:0044267|cellular protein metabolic process;GO:0043542|endothelial cell migration;GO:0048245|eosinophil chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0000165|MAPK cascade;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:0001937|negative regulation of endothelial cell proliferation;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0050918|positive chemotaxis;GO:0001938|positive regulation of endothelial cell proliferation;GO:0043687|post-translational protein modification;GO:0009306|protein secretion;","GO:0005788|endoplasmic reticulum lumen;GO:0005615|extracellular space;","GO:0042056|chemoattractant activity;GO:0005125|cytokine activity;",".","."]
["ENSG00000118655",465,488,483,811.044875740487,972,1190,1509,0.467211672676722,-1.09785177635767,1.06098391311779e-46,2.86614253728515e-45,"down","yes","DCLRE1B","protein_coding","chr1:113905141-113914086:+","gi|12383082|ref|NP_073747.1|",2846,0,"5' exonuclease Apollo isoform a [Homo sapiens]","gi|931564413|ref|XM_003805664.3|",3818,0,"PREDICTED: Pan paniscus DNA cross-link repair 1B (DCLRE1B), mRNA","Q9H816",1100,0,"5' exonuclease Apollo","SPAC22A12.01c",128,5e-30,"COG1236","pfam07522","DRMBL","DNA repair metallo-beta-lactamase. The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in pfam00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair.","GO:0000075|cell cycle checkpoint;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0036297|interstrand cross-link repair;GO:0031848|protection from non-homologous end joining at telomere;GO:0016233|telomere capping;GO:0000723|telomere maintenance;GO:0010833|telomere maintenance via telomere lengthening;GO:0031860|telomeric 3' overhang formation;GO:0031627|telomeric loop formation;","GO:0005813|centrosome;GO:0000781|chromosome, telomeric region;GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;","GO:0035312|5'-3' exodeoxyribonuclease activity;GO:0008409|5'-3' exonuclease activity;GO:0003684|damaged DNA binding;GO:0042803|protein homodimerization activity;GO:0044877|macromolecular complex binding;","K15341","DCLRE1B, SNM1B; DNA cross-link repair 1B protein [EC:3.1.-.-]"]
["ENSG00000163083",264,211,225,394.105982803699,479,559,748,0.467190364664026,-1.09791757451098,2.22169334149883e-25,3.32186210626585e-24,"down","yes","INHBB","protein_coding","chr2:120346143-120351808:+","gi|724888864|ref|XP_010374746.1|",1849,0,"PREDICTED: inhibin beta B chain [Rhinopithecus roxellana]","gi|154813203|ref|NM_002193.2|",3203,0,"Homo sapiens inhibin beta B (INHBB), mRNA","P09529",712,0,"Inhibin beta B chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0032924|activin receptor signaling pathway;GO:0048468|cell development;GO:0030154|cell differentiation;GO:0032869|cellular response to insulin stimulus;GO:0044320|cellular response to leptin stimulus;GO:0009267|cellular response to starvation;GO:0006952|defense response;GO:0045444|fat cell differentiation;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0048178|negative regulation of hepatocyte growth factor biosynthetic process;GO:0046676|negative regulation of insulin secretion;GO:0048599|oocyte development;GO:0001541|ovarian follicle development;GO:2001235|positive regulation of apoptotic signaling pathway;GO:0046881|positive regulation of follicle-stimulating hormone secretion;GO:0060279|positive regulation of ovulation;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0009611|response to wounding;GO:0060395|SMAD protein signal transduction;","GO:0071944|cell periphery;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0048471|perinuclear region of cytoplasm;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0046789|host cell surface receptor binding;GO:0042803|protein homodimerization activity;GO:0005160|transforming growth factor beta receptor binding;","K04667","INHB; inhibin, beta"]
["ENSG00000108821",106,107,98,175.20787375058,177,292,333,0.466383411608877,-1.10041161941759,8.82314136131149e-12,6.71854522609459e-11,"down","yes","COL1A1","protein_coding","chr17:50183289-50201632:-","gi|119615036|gb|EAW94630.1|",1447,5e-172,"collagen, type I, alpha 1, isoform CRA_a [Homo sapiens]","gi|1418927|emb|Z74615.1|",6619,0,"H.sapiens mRNA for prepro-alpha1(I) collagen","P02452",564,4e-168,"Collagen alpha-1(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0007596|blood coagulation;GO:0001568|blood vessel development;GO:0060346|bone trabecula formation;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:1902618|cellular response to fluoride;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071306|cellular response to vitamin E;GO:0032964|collagen biosynthetic process;GO:0030199|collagen fibril organization;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0048706|embryonic skeletal system development;GO:0001958|endochondral ossification;GO:0030198|extracellular matrix organization;GO:0060325|face morphogenesis;GO:0001957|intramembranous ossification;GO:0050900|leukocyte migration;GO:0010812|negative regulation of cell-substrate adhesion;GO:0001649|osteoblast differentiation;GO:0030168|platelet activation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0030335|positive regulation of cell migration;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0045893|positive regulation of transcription, DNA-templated;GO:0070208|protein heterotrimerization;GO:0034504|protein localization to nucleus;GO:0015031|protein transport;GO:0050776|regulation of immune response;GO:0051591|response to cAMP;GO:0031960|response to corticosteroid;GO:0032355|response to estradiol;GO:0042542|response to hydrogen peroxide;GO:0055093|response to hyperoxia;GO:0043434|response to peptide hormone;GO:0007605|sensory perception of sound;GO:0001501|skeletal system development;GO:0043589|skin morphogenesis;GO:0044691|tooth eruption;GO:0034505|tooth mineralization;GO:0007601|visual perception;","GO:0005584|collagen type I trimer;GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;","GO:0005201|extracellular matrix structural constituent;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;GO:0002020|protease binding;","K06236","COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha"]
["ENSG00000099901",2129,1898,1888,3337.01731748942,3993,4889,6246,0.466339082796651,-1.10054875121831,2.94804050802623e-156,3.64498752043654e-154,"down","yes","RANBP1","protein_coding","chr22:20115938-20127357:+","gi|694981854|ref|XP_009436087.1|",753,2e-90,"PREDICTED: ran-specific GTPase-activating protein isoform X1 [Pan troglodytes]","gi|21753465|dbj|AK094410.1|",2171,0,"Homo sapiens cDNA FLJ37091 fis, clone BRACE2017720, moderately similar to RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN","P43487",110,7e-26,"Ran-specific GTPase-activating protein","SPBC1773.07c",56.2,4e-08,"COG5171","pfam00638","Ran_BP1","RanBP1 domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0046604|positive regulation of mitotic centrosome separation;GO:0006606|protein import into nucleus;GO:0006405|RNA export from nucleus;GO:0007165|signal transduction;GO:0007051|spindle organization;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016032|viral process;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005635|nuclear envelope;GO:0005634|nucleus;","GO:0045296|cadherin binding;GO:0005092|GDP-dissociation inhibitor activity;GO:0005096|GTPase activator activity;GO:0008536|Ran GTPase binding;","K15306","RANBP1; Ran-binding protein 1"]
["ENSG00000134871",2057,1938,1798,3269.61819135515,3871,4831,6137,0.465905394287852,-1.10189106071212,2.99879318684683e-157,3.73165954760656e-155,"down","yes","COL4A2","protein_coding","chr13:110305812-110513209:+","gi|116256354|ref|NP_001837.2|",3323,0,"collagen alpha-2(IV) chain preproprotein [Homo sapiens]","gi|116256353|ref|NM_001846.2|",6252,0,"Homo sapiens collagen type IV alpha 2 (COL4A2), mRNA","P08572",1284,0,"Collagen alpha-2(IV) chain",".",".",".",".","pfam01413","C4","C-terminal tandem repeated domain in type 4 procollagen. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.","GO:0007568|aging;GO:0001525|angiogenesis;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0035987|endodermal cell differentiation;GO:0030198|extracellular matrix organization;GO:0016525|negative regulation of angiogenesis;GO:0014823|response to activity;GO:0006351|transcription, DNA-templated;","GO:0005587|collagen type IV trimer;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;","GO:0005201|extracellular matrix structural constituent;","K06237","COL4A; collagen, type IV, alpha"]
["ENSG00000149679",274,270,221,432.146822671068,546,616,789,0.465438915180972,-1.10333625588561,9.55274172976185e-28,1.57481438020211e-26,"down","yes","CABLES2","protein_coding","chr20:62388632-62407285:-","gi|145275195|ref|NP_112492.2|",2061,0,"CDK5 and ABL1 enzyme substrate 2 [Homo sapiens]","gi|145275194|ref|NM_031215.2|",3783,0,"Homo sapiens Cdk5 and Abl enzyme substrate 2 (CABLES2), mRNA","Q9BTV7",798,0,"CDK5 and ABL1 enzyme substrate 2",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0051726|regulation of cell cycle;",".",".",".","."]
["ENSG00000090889",800,853,747,1357.08964182545,1568,2063,2536,0.465282014512986,-1.1038226741245,8.46443281362742e-69,3.40839206908655e-67,"down","yes","KIF4A","protein_coding","chrX:70290090-70420832:+","gi|62087174|dbj|BAD92034.1|",6116,0,"Chromosome-associated kinesin KIF4A variant [Homo sapiens]","gi|291167753|ref|NM_012310.4|",4345,0,"Homo sapiens kinesin family member 4A (KIF4A), mRNA","O95239",2358,0,"Chromosome-associated kinesin KIF4A","SPAC1834.07",246,1e-68,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0008089|anterograde axon cargo transport;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007018|microtubule-based movement;GO:0000281|mitotic cytokinesis;GO:0051256|mitotic spindle midzone assembly;GO:0006996|organelle organization;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:1904115|axon cytoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0045171|intercellular bridge;GO:0005871|kinesin complex;GO:0016020|membrane;GO:0030496|midbody;GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;GO:0005876|spindle microtubule;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0003677|DNA binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10395","KIF4_21_27; kinesin family member 4/21/27"]
["ENSG00000178531",59,57,61,100.339118187333,123,155,174,0.465231049257236,-1.10398071021161,3.49995814219475e-08,1.97274087219907e-07,"down","yes","CTXN1","protein_coding","chr19:7924485-7926166:-","gi|119589362|gb|EAW68956.1|",473,5e-53,"cortexin 1, partial [Homo sapiens]","gi|21758968|dbj|AK098834.1|",1269,0,"Homo sapiens cDNA FLJ25968 fis, clone CBR01977","P60606",90.1,1e-20,"Cortexin-1",".",".",".",".","pfam11057","Cortexin","Cortexin of kidney. In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000114631",66,74,66,116.476315665623,129,176,227,0.46499374677929,-1.104716779852,4.34468304597291e-09,2.63771629180754e-08,"down","yes","PODXL2","protein_coding","chr3:127629181-127672809:+","gi|37183309|gb|AAQ89454.1|",2233,0,"podocalyxin-like protein [Homo sapiens]","gi|409971416|ref|NM_015720.3|",2186,0,"Homo sapiens podocalyxin like 2 (PODXL2), mRNA","Q9NZ53",864,0,"Podocalyxin-like protein 2",".",".",".",".","pfam06365","CD34_antigen","CD34/Podocalyxin family. This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.","GO:0050901|leukocyte tethering or rolling;","GO:0005796|Golgi lumen;GO:0005887|integral component of plasma membrane;","GO:0005539|glycosaminoglycan binding;","K06818","PODXL2; podocalyxin-like 2"]
["ENSG00000186862",37,47,24,61.0247514391767,79,91,104,0.464992955610179,-1.10471923454463,4.18874133164499e-05,0.000168327191489882,"down","yes","PDZD7","protein_coding","chr10:101007683-101032295:-","gi|530394375|ref|XP_005270222.1|",1439,3e-180,"PREDICTED: PDZ domain-containing protein 7 isoform X4 [Homo sapiens]","gi|10440352|dbj|AK024422.1|",4306,0,"Homo sapiens mRNA for FLJ00011 protein, partial cds","Q9H5P4",446,5e-140,"PDZ domain-containing protein 7",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0060088|auditory receptor cell stereocilium organization;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0045184|establishment of protein localization;","GO:0005929|cilium;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0002141|stereocilia ankle link;GO:1990696|USH2 complex;","GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000122133",365,367,330,601.041274223585,717,910,1096,0.464626784152022,-1.10585577188678,1.09183090075448e-39,2.53725715828341e-38,"down","yes","PAEP","protein_coding","chr9:135561756-135566955:+","gi|4884164|emb|CAB43305.1|",890,3e-117,"hypothetical protein [Homo sapiens]","gi|937226997|ref|NM_002571.3|",811,0,"Homo sapiens progestagen-associated endometrial protein (PAEP), transcript variant 2, mRNA","P09466",344,1e-117,"Glycodelin",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0006915|apoptotic process;GO:0007275|multicellular organismal development;GO:1902491|negative regulation of sperm capacitation;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:2000667|positive regulation of interleukin-13 secretion;GO:2000778|positive regulation of interleukin-6 secretion;GO:2000359|regulation of binding of sperm to zona pellucida;","GO:0005576|extracellular region;","GO:0036094|small molecule binding;",".","."]
["ENSG00000144821",12,15,14,23.2300469583671,27,28,52,0.464048254324601,-1.10765326226052,0.00846256491877252,0.0228735919497316,"down","yes","MYH15","protein_coding","chr3:108380369-108529322:-","gi|150010558|ref|NP_055796.1|",9567,0,"myosin-15 precursor [Homo sapiens]","gi|767926066|ref|XM_011512559.1|",7074,0,"PREDICTED: Homo sapiens myosin, heavy chain 15 (MYH15), transcript variant X1, mRNA","Q9Y2K3",3689,0,"Myosin-15","SPCC645.05c",742,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002074|extraocular skeletal muscle development;GO:0007018|microtubule-based movement;","GO:0030016|myofibril;GO:0032982|myosin filament;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10352","MYH; myosin heavy chain"]
["ENSG00000049759",2047,1860,1863,3268.92193672321,3936,4923,5948,0.46394552628544,-1.10797267223149,3.92154284892004e-164,5.1454910523789e-162,"down","yes","NEDD4L","protein_coding","chr18:58044367-58401540:+","gi|795087565|ref|XP_011827094.1|",4730,0,"PREDICTED: E3 ubiquitin-protein ligase NEDD4-like isoform X1 [Mandrillus leucophaeus]","gi|222352182|ref|NM_001144964.1|",8436,0,"Homo sapiens neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L), transcript variant b, mRNA","Q96PU5",1826,0,"E3 ubiquitin-protein ligase NEDD4-like","YER125w",553,9e-171,"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0006883|cellular sodium ion homeostasis;GO:0007588|excretion;GO:0034220|ion transmembrane transport;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1901017|negative regulation of potassium ion transmembrane transporter activity;GO:2000009|negative regulation of protein localization to cell surface;GO:1902306|negative regulation of sodium ion transmembrane transport;GO:2000650|negative regulation of sodium ion transmembrane transporter activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:2001288|positive regulation of caveolin-mediated endocytosis;GO:1903861|positive regulation of dendrite extension;GO:0045807|positive regulation of endocytosis;GO:0045732|positive regulation of protein catabolic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936|protein K48-linked ubiquitination;GO:0006513|protein monoubiquitination;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0034765|regulation of ion transmembrane transport;GO:0003254|regulation of membrane depolarization;GO:0042391|regulation of membrane potential;GO:0060306|regulation of membrane repolarization;GO:1901016|regulation of potassium ion transmembrane transporter activity;GO:0042176|regulation of protein catabolic process;GO:0031647|regulation of protein stability;GO:0010038|response to metal ion;GO:0006814|sodium ion transport;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0086005|ventricular cardiac muscle cell action potential;GO:0019058|viral life cycle;GO:0030104|water homeostasis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005794|Golgi apparatus;GO:0005622|intracellular;GO:0005771|multivesicular body;GO:0005654|nucleoplasm;","GO:0044325|ion channel binding;GO:0019870|potassium channel inhibitor activity;GO:0015459|potassium channel regulator activity;GO:0019871|sodium channel inhibitor activity;GO:0017080|sodium channel regulator activity;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;","K13305","NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]"]
["ENSG00000166483",416,358,344,632.728860149236,773,934,1159,0.463828796134207,-1.10833570450588,1.44277760764678e-41,3.5004144020492e-40,"down","yes","WEE1","protein_coding","chr11:9573681-9593457:+","gi|34364945|emb|CAE46020.1|",1025,3e-125,"hypothetical protein [Homo sapiens]","gi|34364944|emb|BX641032.1|",5098,0,"Homo sapiens mRNA; cDNA DKFZp686I18166 (from clone DKFZp686I18166)","P30291",401,6e-121,"Wee1-like protein kinase",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0051301|cell division;GO:0030010|establishment of cell polarity;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0000226|microtubule cytoskeleton organization;GO:0048812|neuron projection morphogenesis;","GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0000287|magnesium ion binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004713|protein tyrosine kinase activity;","K06632","WEE1; wee1-like protein kinase [EC:2.7.11.1]"]
["ENSG00000125450",920,869,895,1522.03428135494,1806,2303,2795,0.46377605580846,-1.10849975756432,5.12472892958988e-85,2.73054617662789e-83,"down","yes","NUP85","protein_coding","chr17:75205659-75235758:+","gi|194391210|dbj|BAG60723.1|",2373,0,"unnamed protein product [Homo sapiens]","gi|194391209|dbj|AK298519.1|",2221,0,"Homo sapiens cDNA FLJ59373 complete cds, highly similar to Homo sapiens pericentrin 1 (PCNT1), mRNA","Q9BW27",801,0,"Nuclear pore complex protein Nup85",".",".",".",".","pfam07575","Nucleopor_Nup85","Nup85 Nucleoporin. A family of nucleoporins conserved from yeast to human. THe nuclear pore complex is a large assembly composed of two essential complexes: the heptameric Nup84 complex and the heteromeric Nic96-containing complex. The Nup84 complex is composed of one copy each of Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. The structure of a complex of Nup85 and Seh1 was solved. The N-terminus of Nup85 is inserted and forms a three-stranded blade that completes the Seh1 6-bladed beta-propeller in trans. Following its N-terminal insertion blade, Nup85 forms a compact cuboid structure composed of 20 helices, with two distinct modules, referred to as crown and trunk.","GO:0030032|lamellipodium assembly;GO:0048246|macrophage chemotaxis;GO:0006406|mRNA export from nucleus;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006606|protein import into nucleus;GO:0016032|viral process;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0031965|nuclear membrane;GO:0031080|nuclear pore outer ring;GO:0005634|nucleus;GO:0005819|spindle;","GO:0017056|structural constituent of nuclear pore;","K14304","NUP85; nuclear pore complex protein Nup85"]
["ENSG00000196230",10706,10566,9699,17561.0864741399,20520,26001,33478,0.463380763809063,-1.10972993962138,1.11966334765175e-256,3.04169952809958e-254,"down","yes","TUBB","protein_coding","chr6:30720201-30725426:+","gi|74223737|dbj|BAE28709.1|",2104,0,"unnamed protein product [Mus musculus]","gi|645912979|ref|NM_001293215.1|",2308,0,"Homo sapiens tubulin beta class I (TUBB), transcript variant 5, mRNA","P09244",813,0,"Tubulin beta-7 chain","ECU03g0820i",684,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07375","TUBB; tubulin beta"]
["ENSG00000229124",37,41,38,65.7461713414872,78,77,148,0.463094432838714,-1.11062168132288,2.25776493724696e-05,9.44022764136559e-05,"down","yes","VIM-AS1","antisense","chr10:17214239-17229985:-",".",".",".",".","gi|563580306|ref|NR_108060.1|",1351,0,"Homo sapiens VIM antisense RNA 1 (VIM-AS1), transcript variant 2, long non-coding RNA",".",".",".",".",".",".",".",".","pfam03051","Peptidase_C1_2","Peptidase C1-like family. This family is closely related to the Peptidase_C1 family pfam00112, containing several prokaryotic and eukaryotic aminopeptidases and bleomycin hydrolases.",".",".",".",".","."]
["ENSG00000251602",20,15,15,28.4691833571647,41,48,36,0.462672057791918,-1.1119381222048,0.00437185283861209,0.0125875947979027,"down","yes","AL928654.1","antisense","chr14:105416884-105419739:-","gi|635129910|ref|XP_007986320.1|",383,3e-35,"PREDICTED: metastasis-associated protein MTA1 [Chlorocebus sabaeus]","gi|551879655|tpe|HG506704.1|",2279,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000409066.1 (RP11-521B24.3 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000174501",194,176,147,293.407458640609,378,473,462,0.462565413006759,-1.11227069823684,1.447681626615e-17,1.53422435242583e-16,"down","yes","ANKRD36C","protein_coding","chr2:95836919-95991831:-","gi|302393829|sp|Q5JPF3.3|AN36C_HUMAN",9178,0,"RecName: Full=Ankyrin repeat domain-containing protein 36C; AltName: Full=Protein immuno-reactive with anti-PTH polyclonal antibodies","gi|862669337|ref|NM_001310154.1|",3182,0,"Homo sapiens ankyrin repeat domain 36C (ANKRD36C), mRNA","Q5JPF3",3539,0,"Ankyrin repeat domain-containing protein 36C","all2748",80.9,1e-14,"COG0666","pfam14915","CCDC144C","CCDC144C protein coiled-coil region. This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.",".",".","GO:0008200|ion channel inhibitor activity;",".","."]
["ENSG00000158402",293,248,243,444.852297577212,553,670,787,0.462505424045895,-1.11245780991089,4.64508421900547e-30,8.18961466327034e-29,"down","yes","CDC25C","protein_coding","chr5:138285265-138338355:-","gi|969812512|ref|NP_001305027.1|",1441,0,"M-phase inducer phosphatase 3 isoform e [Homo sapiens]","gi|969812511|ref|NM_001318098.1|",924,0,"Homo sapiens cell division cycle 25C (CDC25C), transcript variant 5, mRNA","P30307",559,0,"M-phase inducer phosphatase 3","SPAC24H6.05",142,7e-35,"COG5105","pfam06617","M-inducer_phosp","M-phase inducer phosphatase. This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the pfam00581 domain. These proteins are involved in the control of mitosis.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0000086|G2/M transition of mitotic cell cycle;GO:1902751|positive regulation of cell cycle G2/M phase transition;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0007088|regulation of mitotic nuclear division;GO:0007283|spermatogenesis;GO:0016032|viral process;","GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0004721|phosphoprotein phosphatase activity;GO:0019901|protein kinase binding;GO:0004725|protein tyrosine phosphatase activity;GO:0050699|WW domain binding;","K05867","CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]"]
["ENSG00000272655",98,73,58,129.254130991677,156,194,237,0.462481299192679,-1.11253306462586,1.59818847075012e-09,1.01601381752895e-08,"down","yes","POLR2J4","transcribed_unprocessed_pseudogene","chr7:44013562-44019170:-","gi|530386126|ref|XP_005250509.1|",815,3e-104,"PREDICTED: DNA-directed RNA polymerase II subunit RPB11-a isoform X1 [Homo sapiens]","gi|33878912|gb|BC017250.2|",1419,0,"Homo sapiens polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene, mRNA (cDNA clone IMAGE:5017025)","P52435",211,6e-65,"DNA-directed RNA polymerase II subunit RPB11-a","YOL005c",106,2e-26,"COG1761","pfam13656","RNA_pol_L_2","RNA polymerase Rpb3/Rpb11 dimerization domain. The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.","GO:0006370|7-methylguanosine mRNA capping;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0000398|mRNA splicing, via spliceosome;GO:0060964|regulation of gene silencing by miRNA;GO:0016070|RNA metabolic process;GO:0042795|snRNA transcription from RNA polymerase II promoter;GO:0006366|transcription from RNA polymerase II promoter;GO:0006368|transcription elongation from RNA polymerase II promoter;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0006283|transcription-coupled nucleotide-excision repair;","GO:0005665|DNA-directed RNA polymerase II, core complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003899|DNA-directed RNA polymerase activity;GO:0030275|LRR domain binding;GO:0046983|protein dimerization activity;GO:0001055|RNA polymerase II activity;","K03008","RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11"]
["ENSG00000182175",21,12,14,26.696837549686,36,43,40,0.46123294042836,-1.11643254352908,0.00469412816434687,0.0134472514531297,"down","yes","RGMA","protein_coding","chr15:93035273-93089204:-","gi|332844703|ref|XP_510608.3|",2027,0,"PREDICTED: repulsive guidance molecule A isoform X2 [Pan troglodytes]","gi|21672216|gb|AC087641.5|",10432,0,"Homo sapiens chromosome 15, clone RP11-368J22, complete sequence","Q96B86",783,0,"Repulsive guidance molecule A",".",".",".",".","pfam06534","RGM_C","Repulsive guidance molecule (RGM) C-terminus. This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.","GO:0030509|BMP signaling pathway;GO:0048681|negative regulation of axon regeneration;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0031225|anchored component of membrane;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;","GO:0015026|coreceptor activity;GO:1990459|transferrin receptor binding;","K06847","RGM; RGM domain family"]
["ENSG00000265415",176,183,142,284.211536915544,315,435,552,0.461113224307368,-1.1168070533642,7.81193422791885e-19,8.84771505508507e-18,"down","yes","AC099850.3","antisense","chr17:59202677-59203829:-","gi|119617896|gb|EAW97490.1|",134,2e-08,"hCG2038211, partial [Homo sapiens]","gi|551885408|tpe|HG509293.1|",321,3e-166,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000445959.1 (CTD-2510F5.4 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000128228",392,419,369,672.633225949031,855,921,1277,0.460459423480923,-1.11885406587168,7.66668110506614e-38,1.67279349722303e-36,"down","yes","SDF2L1","protein_coding","chr22:21642261-21644298:+","gi|795171790|ref|XP_011842735.1|",945,5e-125,"PREDICTED: stromal cell-derived factor 2-like protein 1 isoform X2 [Mandrillus leucophaeus]","gi|56243532|ref|NM_022044.2|",865,0,"Homo sapiens stromal cell derived factor 2 like 1 (SDF2L1), mRNA","Q9HCN8",357,1e-122,"Stromal cell-derived factor 2-like protein 1","YOR321w",50.4,3e-06,"COG1928","pfam02815","MIR","MIR domain. The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.","GO:0071712|ER-associated misfolded protein catabolic process;GO:0042981|regulation of apoptotic process;","GO:0034663|endoplasmic reticulum chaperone complex;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;","GO:0051117|ATPase binding;GO:0051087|chaperone binding;GO:0004169|dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0051787|misfolded protein binding;",".","."]
["ENSG00000166881",1262,1245,1143,2080.20335467738,2525,3167,3743,0.460130655620419,-1.11988451751978,4.03734066197662e-115,3.21786060695062e-113,"down","yes","NEMP1","protein_coding","chr12:57055643-57088063:-","gi|48735178|gb|AAH71597.1|",1891,0,"TMEM194A protein, partial [Homo sapiens]","gi|195972880|ref|NM_001130963.1|",5590,0,"Homo sapiens nuclear envelope integral membrane protein 1 (NEMP1), transcript variant 1, mRNA","Q5RDB4",727,0,"Nuclear envelope integral membrane protein 1",".",".",".",".","pfam10225","DUF2215","Uncharacterized conserved protein (DUF2215). This entry is the central 200 residues of a family of proteins conserved from worms to humans. The function is unknown.",".","GO:0016021|integral component of membrane;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;",".",".","."]
["ENSG00000176974",383,390,352,641.449093091303,782,980,1145,0.460103336530326,-1.1199701764199,2.89570716023482e-42,7.14225060186818e-41,"down","yes","SHMT1","protein_coding","chr17:18327860-18363563:-","gi|5830438|emb|CAB54839.1|",224,8e-17,"cytosolic serine hydroxymethyltransferase [Homo sapiens]","gi|294712574|ref|NG_017111.1|",2756,0,"Homo sapiens serine hydroxymethyltransferase 1 (soluble) (SHMT1), RefSeqGene on chromosome 17","P34896",90.9,1e-17,"Serine hydroxymethyltransferase, cytosolic","ZglyA",55.8,3e-07,"COG0112","pfam00464","SHMT","Serine hydroxymethyltransferase.","GO:0045329|carnitine biosynthetic process;GO:1990830|cellular response to leukemia inhibitory factor;GO:1904482|cellular response to tetrahydrofolate;GO:0006231|dTMP biosynthetic process;GO:0046655|folic acid metabolic process;GO:0019264|glycine biosynthetic process from serine;GO:0006544|glycine metabolic process;GO:0006565|L-serine catabolic process;GO:0006563|L-serine metabolic process;GO:0017148|negative regulation of translation;GO:0051289|protein homotetramerization;GO:0051262|protein tetramerization;GO:0009113|purine nucleobase biosynthetic process;GO:0035999|tetrahydrofolate interconversion;GO:0046653|tetrahydrofolate metabolic process;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005634|nucleus;","GO:0004372|glycine hydroxymethyltransferase activity;GO:0042802|identical protein binding;GO:0008732|L-allo-threonine aldolase activity;GO:0048027|mRNA 5'-UTR binding;GO:0042803|protein homodimerization activity;GO:0030170|pyridoxal phosphate binding;GO:0070905|serine binding;GO:0000900|translation repressor activity, nucleic acid binding;","K00600","glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]"]
["ENSG00000065361",67,68,51,105.732924344034,113,190,178,0.459979708393814,-1.12035787555536,6.77661812816548e-08,3.70696002427838e-07,"down","yes","ERBB3","protein_coding","chr12:56076799-56103505:+","gi|54792100|ref|NP_001973.2|",6450,0,"receptor tyrosine-protein kinase erbB-3 isoform 1 precursor [Homo sapiens]","gi|694949527|ref|XM_509131.4|",5774,0,"PREDICTED: Pan troglodytes v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), mRNA","P21860",2487,0,"Receptor tyrosine-protein kinase erbB-3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0021545|cranial nerve development;GO:0003197|endocardial cushion development;GO:0038128|ERBB2 signaling pathway;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0007507|heart development;GO:0000165|MAPK cascade;GO:0007162|negative regulation of cell adhesion;GO:0043524|negative regulation of neuron apoptotic process;GO:0051048|negative regulation of secretion;GO:0009968|negative regulation of signal transduction;GO:0051402|neuron apoptotic process;GO:0007422|peripheral nervous system development;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0055025|positive regulation of cardiac muscle tissue development;GO:0010628|positive regulation of gene expression;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:2000145|regulation of cell motility;GO:0042127|regulation of cell proliferation;GO:0014037|Schwann cell differentiation;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0042060|wound healing;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0016328|lateral plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0042802|identical protein binding;GO:0038132|neuregulin binding;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0030296|protein tyrosine kinase activator activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0004888|transmembrane signaling receptor activity;GO:0031625|ubiquitin protein ligase binding;","K05084","ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]"]
["ENSG00000068028",346,348,293,562.663562128906,691,834,1030,0.459425490733219,-1.12209718955558,1.51164040583864e-37,3.27233671692657e-36,"down","yes","RASSF1","protein_coding","chr3:50329782-50340980:-","gi|194375001|dbj|BAG62613.1|",636,1e-75,"unnamed protein product [Homo sapiens]","gi|300116279|ref|NG_023270.1|",1635,0,"Homo sapiens Ras association domain family member 1 (RASSF1), RefSeqGene on chromosome 3","Q9NS23",247,2e-73,"Ras association domain-containing protein 1",".",".",".",".","pfam00130","C1_1","Phorbol esters/diacylglycerol binding domain (C1 domain). This domain is also known as the Protein kinase C conserved region 1 (C1) domain.","GO:0007050|cell cycle arrest;GO:0006974|cellular response to DNA damage stimulus;GO:0071157|negative regulation of cell cycle arrest;GO:0031398|positive regulation of protein ubiquitination;GO:0050821|protein stabilization;GO:0007265|Ras protein signal transduction;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0005815|microtubule organizing center;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;GO:0047485|protein N-terminus binding;GO:0008270|zinc ion binding;","K09850","RASSF1; Ras association domain-containing protein 1"]
["ENSG00000144583",670,645,599,1090.97906552019,1314,1576,2084,0.459409992883166,-1.12214585696518,2.36372167258438e-66,9.0819648647027e-65,"down","yes","2020-03-04","protein_coding","chr2:216257865-216372027:-","gi|57977325|ref|NP_065865.1|",1671,0,"E3 ubiquitin-protein ligase MARCH4 precursor [Homo sapiens]","gi|212276234|ref|NM_020814.2|",4447,0,"Homo sapiens membrane associated ring-CH-type finger 4 (MARCH4), mRNA","Q9P2E8",648,0,"E3 ubiquitin-protein ligase MARCH4","ECU06g0830",55.8,1e-06,"COG5183","pfam12906","RINGv","RING-variant domain.",".","GO:0000139|Golgi membrane;GO:0005795|Golgi stack;GO:0016021|integral component of membrane;GO:0005802|trans-Golgi network;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10659","MARCH4_9_11; E3 ubiquitin-protein ligase MARCH4/9/11 [EC:2.3.2.27]"]
["ENSG00000151882",15,17,14,26.3140625436053,31,49,38,0.459369652103382,-1.12227254554235,0.00478169486903542,0.0136696799516756,"down","yes","CCL28","protein_coding","chr5:43376645-43412391:-","gi|22538811|ref|NP_683513.1|",573,2e-65,"C-C motif chemokine 28 isoform a precursor [Homo sapiens]","gi|687569428|ref|NM_148672.3|",3126,0,"Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1, mRNA","Q9NRJ3",225,6e-67,"C-C motif chemokine 28",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0060326|cell chemotaxis;GO:0006935|chemotaxis;GO:0051715|cytolysis in other organism;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0031640|killing of cells of other organism;GO:1903237|negative regulation of leukocyte tethering or rolling;GO:0001954|positive regulation of cell-matrix adhesion;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007584|response to nutrient;","GO:0005623|cell;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;","K05513","CCL28; C-C motif chemokine 28"]
["ENSG00000024526",875,784,768,1383.87866012445,1709,1985,2600,0.459230217086188,-1.1227105212402,9.91377563624083e-81,4.80444483597521e-79,"down","yes","DEPDC1","protein_coding","chr1:68474152-68497221:-","gi|166295188|ref|NP_001107592.1|",4060,0,"DEP domain-containing protein 1A isoform a [Homo sapiens]","gi|564473350|ref|NM_001114120.2|",5331,0,"Homo sapiens DEP domain containing 1 (DEPDC1), transcript variant 1, mRNA","Q5TB30",1572,0,"DEP domain-containing protein 1A",".",".",".",".","pfam00610","DEP","Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP). The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.","GO:0035556|intracellular signal transduction;GO:0045892|negative regulation of transcription, DNA-templated;GO:0007165|signal transduction;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0017053|transcriptional repressor complex;","GO:0005096|GTPase activator activity;",".","."]
["ENSG00000167711",23,17,11,28.8985097102291,39,33,60,0.458336494566853,-1.12552093150889,0.0036602355085427,0.0107162450650837,"down","yes","SERPINF2","protein_coding","chr17:1742836-1755268:+","gi|530410440|ref|XP_005256757.1|",2495,0,"PREDICTED: alpha-2-antiplasmin isoform X5 [Homo sapiens]","gi|124053441|ref|NM_000934.3|",2284,0,"Homo sapiens serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (SERPINF2), transcript variant 1, mRNA","P08697",960,0,"Alpha-2-antiplasmin","all0778",132,2e-32,"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0006953|acute-phase response;GO:0048514|blood vessel morphogenesis;GO:0030199|collagen fibril organization;GO:0042730|fibrinolysis;GO:0051918|negative regulation of fibrinolysis;GO:0010757|negative regulation of plasminogen activation;GO:0002576|platelet degranulation;GO:0045597|positive regulation of cell differentiation;GO:2000049|positive regulation of cell-cell adhesion mediated by cadherin;GO:0032967|positive regulation of collagen biosynthetic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0046330|positive regulation of JNK cascade;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051496|positive regulation of stress fiber assembly;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0071636|positive regulation of transforming growth factor beta production;GO:0002034|regulation of blood vessel size by renin-angiotensin;GO:0010033|response to organic substance;","GO:0072562|blood microparticle;GO:0009986|cell surface;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005577|fibrinogen complex;GO:0031093|platelet alpha granule lumen;","GO:0004866|endopeptidase inhibitor activity;GO:0002020|protease binding;GO:0042803|protein homodimerization activity;GO:0004867|serine-type endopeptidase inhibitor activity;","K03983","SERPINF2, AAP; alpha-2-antiplasmin"]
["ENSG00000109881",252,201,186,364.469137665026,452,515,695,0.457295160947295,-1.12880244211965,4.38425433855135e-24,6.21333561219533e-23,"down","yes","CCDC34","protein_coding","chr11:27330827-27363868:-","gi|119588694|gb|EAW68288.1|",841,8e-104,"coiled-coil domain containing 34, isoform CRA_b [Homo sapiens]","gi|63054846|ref|NM_080654.2|",2106,0,"Homo sapiens coiled-coil domain containing 34 (CCDC34), transcript variant 2, mRNA","Q96HJ3",251,1e-74,"Coiled-coil domain-containing protein 34",".",".",".",".","pfam13904","DUF4207","Domain of unknown function (DUF4207). This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.",".",".",".","K16753","CCDC34; coiled-coil domain-containing protein 34"]
["ENSG00000117748",735,659,653,1171.46071473619,1453,1719,2154,0.457097576372091,-1.129425925399,3.3364822965595e-74,1.4828126851622e-72,"down","yes","RPA2","protein_coding","chr1:27891524-27914746:-","gi|347543774|ref|NP_001125362.2|",1562,0,"replication protein A 32 kDa subunit [Pongo abelii]","gi|554595584|ref|NM_002946.4|",1752,0,"Homo sapiens replication protein A2 (RPA2), transcript variant 1, mRNA","P15927",515,1e-179,"Replication protein A 32 kDa subunit","SPCC1753.01c",105,3e-24,"COG5235","pfam08784","RPA_C","Replication protein A C terminal. This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.","GO:0006284|base-excision repair;GO:0042769|DNA damage response, detection of DNA damage;GO:0006260|DNA replication;GO:0000724|double-strand break repair via homologous recombination;GO:0070987|error-free translesion synthesis;GO:0042276|error-prone translesion synthesis;GO:0000082|G1/S transition of mitotic cell cycle;GO:0036297|interstrand cross-link repair;GO:0006298|mismatch repair;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0006289|nucleotide-excision repair;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294|nucleotide-excision repair, preincision complex assembly;GO:0006293|nucleotide-excision repair, preincision complex stabilization;GO:0034502|protein localization to chromosome;GO:1900034|regulation of cellular response to heat;GO:2000001|regulation of DNA damage checkpoint;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0000723|telomere maintenance;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0000785|chromatin;GO:0005662|DNA replication factor A complex;GO:0016604|nuclear body;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;","GO:0003684|damaged DNA binding;GO:0019899|enzyme binding;GO:0098505|G-rich strand telomeric DNA binding;GO:0047485|protein N-terminus binding;GO:0019903|protein phosphatase binding;GO:0003697|single-stranded DNA binding;GO:0031625|ubiquitin protein ligase binding;","K10739","RFA2, RPA2; replication factor A2"]
["ENSG00000140534",449,393,338,673.905280777139,812,993,1272,0.456615494683652,-1.13094827841721,2.67161202353171e-42,6.59795809345449e-41,"down","yes","TICRR","protein_coding","chr15:89575482-89631056:+","gi|118421085|ref|NP_689472.3|",9308,0,"treslin isoform 2 [Homo sapiens]","gi|118421084|ref|NM_152259.3|",6670,0,"Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA","Q7Z2Z1",3588,0,"Treslin",".",".",".",".","pfam15292","Treslin_N","Treslin N-terminus. This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation.","GO:0000075|cell cycle checkpoint;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0001731|formation of translation preinitiation complex;GO:0033314|mitotic DNA replication checkpoint;GO:0030174|regulation of DNA-dependent DNA replication initiation;GO:0010212|response to ionizing radiation;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;",".","."]
["ENSG00000237686",12,15,12,22.2497544591909,16,45,43,0.456603300327086,-1.13098680749226,0.0115820998836817,0.0303898166992862,"down","yes","AL109615.3","antisense","chr6:43995723-44074652:-","gi|285002262|ref|NP_001165463.1|",178,4e-12,"uncharacterized protein C6orf223 isoform 2 [Homo sapiens]","gi|674779873|ref|NR_125864.1|",2232,0,"Homo sapiens uncharacterized LOC101929705 (LOC101929705), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000090539",18,15,13,26.2557200580505,30,42,48,0.456411826865147,-1.13159191864502,0.00350982114695894,0.0103277516044849,"down","yes","CHRD","protein_coding","chr3:184380073-184390736:+","gi|62087474|dbj|BAD92184.1|",1422,4e-180,"chordin isoform a variant [Homo sapiens]","gi|62087473|dbj|AB208947.1|",4480,0,"Homo sapiens mRNA for chordin isoform a variant protein","Q9H2X0",416,3e-123,"Chordin",".",".",".",".","pfam07452","CHRD","CHRD domain. CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologues. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..","GO:0021919|BMP signaling pathway involved in spinal cord dorsal/ventral patterning;GO:0033504|floor plate development;GO:0030900|forebrain development;GO:0001702|gastrulation with mouth forming second;GO:0001707|mesoderm formation;GO:0030514|negative regulation of BMP signaling pathway;GO:0030336|negative regulation of cell migration;GO:0045668|negative regulation of osteoblast differentiation;GO:0001649|osteoblast differentiation;GO:0045785|positive regulation of cell adhesion;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0001501|skeletal system development;","GO:0005615|extracellular space;","GO:0019955|cytokine binding;GO:0008201|heparin binding;GO:0045545|syndecan binding;","K04657","CHRD; chordin"]
["ENSG00000111348",2250,2097,1882,3567.93023193857,4151,5451,6729,0.455473950893343,-1.13455954797666,1.11660276920153e-151,1.33770398834529e-149,"down","yes","ARHGDIB","protein_coding","chr12:14942017-14961728:-","gi|56676393|ref|NP_001166.3|",1004,6e-133,"rho GDP-dissociation inhibitor 2 [Homo sapiens]","gi|404044|gb|L20688.1|HUMLYGDI",1226,0,"Human GDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds","P52566",391,2e-134,"Rho GDP-dissociation inhibitor 2",".",".",".",".","pfam02115","Rho_GDI","RHO protein GDP dissociation inhibitor.","GO:0071461|cellular response to redox state;GO:0007275|multicellular organismal development;GO:0007162|negative regulation of cell adhesion;GO:1901164|negative regulation of trophoblast cell migration;GO:2000249|regulation of actin cytoskeleton reorganization;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;","GO:0005096|GTPase activator activity;GO:0003924|GTPase activity;GO:0048365|Rac GTPase binding;GO:0005094|Rho GDP-dissociation inhibitor activity;","K12462","ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor"]
["ENSG00000145860",2689,2612,2486,4468.41760810524,5333,6716,8358,0.45542132091352,-1.13472626090915,3.03020756861052e-205,5.78679639439205e-203,"down","yes","RNF145","protein_coding","chr5:159157409-159210053:-","gi|530380875|ref|XP_005265883.1|",3333,0,"PREDICTED: RING finger protein 145 isoform X1 [Homo sapiens]","gi|313661396|ref|NM_001199383.1|",3569,0,"Homo sapiens ring finger protein 145 (RNF145), transcript variant 5, mRNA","Q96MT1",1274,0,"RING finger protein 145",".",".",".",".","pfam13705","TRC8_N","TRC8 N-terminal domain. This region is found at the N-terminus of the TRC8 protein. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG.","GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209|protein polyubiquitination;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0061630|ubiquitin protein ligase activity;GO:0008270|zinc ion binding;",".","."]
["ENSG00000125285",32,37,21,51.6995179461323,77,60,96,0.454409302655312,-1.13793572492745,0.000141443733283339,0.000528509633391909,"down","yes","SOX21","protein_coding","chr13:94709622-94712399:-","gi|586447766|ref|XP_006832065.1|",767,7e-91,"PREDICTED: transcription factor SOX-21 isoform X1 [Chrysochloris asiatica]","gi|751130481|ref|NM_007084.3|",2778,0,"Homo sapiens SRY-box 21 (SOX21), mRNA","Q9Y651",300,2e-92,"Transcription factor SOX-21",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0001942|hair follicle development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;GO:0048863|stem cell differentiation;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09267","SOX1S; transcription factor SOX1/3/14/21 (SOX group B)"]
["ENSG00000146555",124,116,89,188.774929096705,232,274,357,0.453478620095581,-1.14089356047133,2.55510886856051e-14,2.27634826128384e-13,"down","yes","SDK1","protein_coding","chr7:3301448-4269000:+","gi|119220552|ref|NP_689957.3|",10737,0,"protein sidekick-1 isoform 1 [Homo sapiens]","gi|119220551|ref|NM_152744.3|",10397,0,"Homo sapiens sidekick cell adhesion molecule 1 (SDK1), transcript variant 1, mRNA","Q7Z5N4",4143,0,"Protein sidekick-1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0048148|behavioral response to cocaine;GO:0045216|cell-cell junction organization;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060998|regulation of dendritic spine development;GO:0010842|retina layer formation;GO:0007416|synapse assembly;","GO:0030054|cell junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0042802|identical protein binding;","K16353","SDK; protein sidekick"]
["ENSG00000280287",60,44,51,88.8273436914236,94,134,184,0.453241463942723,-1.14164824544957,1.99555480363337e-07,1.0428139000943e-06,"down","yes","AC131212.3","TEC","chr12:132550729-132554947:+","gi|397139480|ref|XP_003846382.1|",1508,0,"PREDICTED: uncharacterized protein LOC100996573 [Homo sapiens]","gi|24431562|gb|AC131212.6|",4219,0,"Homo sapiens 12 BAC RP13-554M15 (Rowsell Park Cancer Institute Human BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000170989",15,16,10,23.5750997979404,30,36,41,0.45292634616697,-1.14265163326721,0.00554487560924107,0.0156267622371481,"down","yes","S1PR1","protein_coding","chr1:101236865-101243713:+","gi|426330537|ref|XP_004026266.1|",2111,0,"PREDICTED: sphingosine 1-phosphate receptor 1 isoform 3 [Gorilla gorilla gorilla]","gi|187281589|ref|NM_001400.4|",2909,0,"Homo sapiens sphingosine-1-phosphate receptor 1 (S1PR1), transcript variant 1, mRNA","P21453",731,0,"Sphingosine 1-phosphate receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0031532|actin cytoskeleton reorganization;GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0001525|angiogenesis;GO:0001955|blood vessel maturation;GO:0007420|brain development;GO:0003245|cardiac muscle tissue growth involved in heart morphogenesis;GO:0007155|cell adhesion;GO:0016477|cell migration;GO:0006935|chemotaxis;GO:0019221|cytokine-mediated signaling pathway;GO:0045446|endothelial cell differentiation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0061384|heart trabecula morphogenesis;GO:0030032|lamellipodium assembly;GO:0030595|leukocyte chemotaxis;GO:0051497|negative regulation of stress fiber assembly;GO:0030182|neuron differentiation;GO:0030335|positive regulation of cell migration;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0043547|positive regulation of GTPase activity;GO:0050927|positive regulation of positive chemotaxis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0030500|regulation of bone mineralization;GO:0045124|regulation of bone resorption;GO:0030155|regulation of cell adhesion;GO:0003376|sphingosine-1-phosphate signaling pathway;GO:0072678|T cell migration;GO:0019226|transmission of nerve impulse;","GO:0005768|endosome;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0031226|intrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0001664|G-protein coupled receptor binding;GO:0046625|sphingolipid binding;GO:0038036|sphingosine-1-phosphate receptor activity;","K04288","S1PR1, EDG1; sphingosine 1-phosphate receptor 1"]
["ENSG00000169884",82,113,74,155.003658320175,191,216,303,0.452856263230263,-1.14287488397746,8.38311516282578e-11,5.97537048265276e-10,"down","yes","WNT10B","protein_coding","chr12:48965340-48971763:-","gi|532078357|ref|XP_005324955.1|",1906,0,"PREDICTED: protein Wnt-10b [Ictidomys tridecemlineatus]","gi|300193073|ref|NM_003394.3|",2274,0,"Homo sapiens wingless-type MMTV integration site family member 10B (WNT10B), mRNA","P48614",687,0,"Protein Wnt-10b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0009887|organ morphogenesis;GO:0060346|bone trabecula formation;GO:0060070|canonical Wnt signaling pathway;GO:0007050|cell cycle arrest;GO:0045165|cell fate commitment;GO:0007267|cell-cell signaling;GO:0071320|cellular response to cAMP;GO:0071407|cellular response to organic cyclic compound;GO:0071310|cellular response to organic substance;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0002062|chondrocyte differentiation;GO:0061196|fungiform papilla development;GO:0000086|G2/M transition of mitotic cell cycle;GO:0071425|hematopoietic stem cell proliferation;GO:0006629|lipid metabolic process;GO:0014835|myoblast differentiation involved in skeletal muscle regeneration;GO:0050680|negative regulation of epithelial cell proliferation;GO:0045599|negative regulation of fat cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030182|neuron differentiation;GO:0043065|positive regulation of apoptotic process;GO:0030501|positive regulation of bone mineralization;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0030858|positive regulation of epithelial cell differentiation;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0045778|positive regulation of ossification;GO:0045669|positive regulation of osteoblast differentiation;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0051885|positive regulation of anagen;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0050821|protein stabilization;GO:0045598|regulation of fat cell differentiation;GO:0032434|regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0051246|regulation of protein metabolic process;GO:0048641|regulation of skeletal muscle tissue development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0050909|sensory perception of taste;GO:0007165|signal transduction;GO:0048741|skeletal muscle fiber development;GO:0043403|skeletal muscle tissue regeneration;GO:0007224|smoothened signaling pathway;GO:0016055|Wnt signaling pathway;","GO:0005615|extracellular space;","GO:0005109|frizzled binding;GO:0005102|receptor binding;","K01357","WNT10; wingless-type MMTV integration site family, member 10"]
["ENSG00000111788",179,127,117,242.67269881016,306,357,443,0.452623499507897,-1.14361660585612,1.72581735357312e-16,1.73102262692243e-15,"down","yes","AC009533.1","unprocessed_pseudogene","chr12:9277235-9313241:+","gi|119608988|gb|EAW88582.1|",3001,0,"DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae), isoform CRA_g [Homo sapiens]","gi|380420355|ref|NM_001257144.1|",2338,0,"Homo sapiens DEAD/H-box helicase 11 (DDX11), transcript variant 4, mRNA","A8MPP1",1157,0,"Putative ATP-dependent RNA helicase DDX11-like protein 8","SPAC3G6.11",254,4e-81,"COG1199","pfam06733","DEAD_2","DEAD_2. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.","GO:0006139|nucleobase-containing compound metabolic process;","GO:0005730|nucleolus;","GO:0005524|ATP binding;GO:0004003|ATP-dependent DNA helicase activity;GO:0003677|DNA binding;GO:0003723|RNA binding;",".","."]
["ENSG00000273162",8,8,17,19.3368841198894,28,29,29,0.452155236511715,-1.14510992291994,0.0168797517012162,0.0424578596848558,"down","yes","AL133215.2","lincRNA","chr10:101060029-101061005:-",".",".",".",".","gi|551869690|tpe|HG503207.1|",977,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473219.1 (RP11-108L7.15 gene), lincRNA",".",".",".",".",".",".",".",".","pfam12541","DUF3737","Protein of unknown function (DUF3737). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 281 and 297 amino acids in length.",".",".",".",".","."]
["ENSG00000143494",26,17,16,33.9100171321508,43,53,58,0.451569384802013,-1.14698041633076,0.000933870011023625,0.0030764278006189,"down","yes","VASH2","protein_coding","chr1:212950520-212992037:+","gi|666637954|ref|NP_001287985.1|",1644,0,"vasohibin-2 isoform 4 [Homo sapiens]","gi|666637952|ref|NM_001136474.2|",4224,0,"Homo sapiens vasohibin 2 (VASH2), transcript variant 2, mRNA","Q86V25",637,0,"Vasohibin-2",".",".",".",".","pfam14822","Vasohibin","Vasohibin. This family of proteins function as angiogenesis inhibitors in animals.","GO:0060716|labyrinthine layer blood vessel development;GO:0045026|plasma membrane fusion;GO:0045766|positive regulation of angiogenesis;GO:0001938|positive regulation of endothelial cell proliferation;GO:0000768|syncytium formation by plasma membrane fusion;","GO:0005737|cytoplasm;GO:0005576|extracellular region;",".",".","."]
["ENSG00000165304",1269,1158,1155,2068.5172363738,2551,3103,3787,0.45132663707101,-1.14775616668885,2.61752477491732e-124,2.34822408644675e-122,"down","yes","MELK","protein_coding","chr9:36572862-36677683:+","gi|62897181|dbj|BAD96531.1|",3450,0,"maternal embryonic leucine zipper kinase variant [Homo sapiens]","gi|375493529|ref|NM_014791.3|",2485,0,"Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 1, mRNA","Q14680",1333,0,"Maternal embryonic leucine zipper kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006915|apoptotic process;GO:0008283|cell proliferation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0030097|hemopoiesis;GO:0035556|intracellular signal transduction;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0061351|neural precursor cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0046777|protein autophosphorylation;","GO:0005938|cell cortex;GO:0016020|membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0008289|lipid binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004674|protein serine/threonine kinase activity;","K08799","MELK; maternal embryonic leucine zipper kinase [EC:2.7.11.1]"]
["ENSG00000197385",57,53,67,102.570724618955,128,145,196,0.450986071021702,-1.14884521922985,1.51092162585759e-08,8.78584754885172e-08,"down","yes","ZNF860","protein_coding","chr3:31981771-31991628:+","gi|332801011|ref|NP_001131146.2|",3250,0,"zinc finger protein 860 [Homo sapiens]","gi|332801010|ref|NM_001137674.2|",3098,0,"Homo sapiens zinc finger protein 860 (ZNF860), mRNA","A6NHJ4",1256,0,"Zinc finger protein 860",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000018236",18,14,15,27.1128811620565,29,50,45,0.450609582350937,-1.1500501016354,0.00307209191603023,0.00915410302431501,"down","yes","CNTN1","protein_coding","chr12:40692442-41072418:+","gi|795135577|ref|XP_011791492.1|",5350,0,"PREDICTED: contactin-1 isoform X1 [Colobus angolensis palliatus]","gi|366039946|ref|NM_001843.3|",5551,0,"Homo sapiens contactin 1 (CNTN1), transcript variant 1, mRNA","Q12860",2019,0,"Contactin-1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0007155|cell adhesion;GO:0021549|cerebellum development;GO:0031175|neuron projection development;GO:0007219|Notch signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0010765|positive regulation of sodium ion transport;","GO:0031225|anchored component of membrane;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0045121|membrane raft;GO:0043209|myelin sheath;GO:0005886|plasma membrane;","GO:0030246|carbohydrate binding;","K06759","CNTN1; contactin 1"]
["ENSG00000159055",217,226,244,398.195862523315,472,627,721,0.450604351803258,-1.15006684812569,2.05341358605406e-26,3.23052538726025e-25,"down","yes","MIS18A","protein_coding","chr21:32268219-32279069:-","gi|9506437|ref|NP_061817.1|",1144,5e-152,"protein Mis18-alpha [Homo sapiens]","gi|45827699|ref|NM_018944.2|",1571,0,"Homo sapiens MIS18 kinetochore protein A (MIS18A), mRNA","Q9NYP9",442,1e-152,"Protein Mis18-alpha",".",".",".",".","pfam03226","Yippee-Mis18","Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0034080|CENP-A containing nucleosome assembly;GO:0007059|chromosome segregation;GO:0044030|regulation of DNA methylation;","GO:0000785|chromatin;GO:0000775|chromosome, centromeric region;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;","K11564","MIS18, FASP1; kinetochore protein Mis18"]
["ENSG00000198727",7721,7703,7102,13023.5099680893,15041,19633,25295,0.450561384524376,-1.15020442255337,9.57327372438938e-208,1.8651444807679e-205,"down","yes","MT-CYB","protein_coding","chrMT:14747-15887:+","gi|549518444|gb|AGX28356.1|",1311,2e-177,"cytochrome b (mitochondrion) [Homo sapiens]","gi|933907744|gb|KT828339.1|",1141,0,"Homo sapiens haplogroup H2a2a1 mitochondrion, complete genome","P00156",509,1e-178,"Cytochrome b","RC0359",251,3e-78,"COG1290","pfam13631","Cytochrom_B_N_2","Cytochrome b(N-terminal)/b6/petB.","GO:0031100|organ regeneration;GO:0015990|electron transport coupled proton transport;GO:0042538|hyperosmotic salinity response;GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c;GO:0046686|response to cadmium ion;GO:0051592|response to calcium ion;GO:0033590|response to cobalamin;GO:0046688|response to copper ion;GO:0045471|response to ethanol;GO:0033762|response to glucagon;GO:0009408|response to heat;GO:0055093|response to hyperoxia;GO:0001666|response to hypoxia;GO:0046689|response to mercury ion;","GO:0031305|integral component of mitochondrial inner membrane;GO:0005743|mitochondrial inner membrane;GO:0005750|mitochondrial respiratory chain complex III;GO:0005739|mitochondrion;","GO:0046872|metal ion binding;GO:0044877|macromolecular complex binding;GO:0008121|ubiquinol-cytochrome-c reductase activity;","K00412","CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit"]
["ENSG00000205208",406,361,378,662.381040806034,832,966,1226,0.45041126087382,-1.15068519774513,2.74692847860731e-45,7.2380814884396e-44,"down","yes","C4orf46","protein_coding","chr4:158666679-158672255:-","gi|56606125|ref|NP_001008394.1|",442,3e-47,"renal cancer differentiation gene 1 protein [Homo sapiens]","gi|454597948|ref|NM_001008393.3|",3521,0,"Homo sapiens chromosome 4 open reading frame 46 (C4orf46), transcript variant 1, mRNA","Q504U0",174,1e-48,"Renal cancer differentiation gene 1 protein",".",".",".",".","pfam10326","7TM_GPCR_Str","Serpentine type 7TM GPCR chemoreceptor Str. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSG00000267041",162,171,147,277.720872183991,324,466,477,0.450242771119995,-1.15122498178314,3.07438032496452e-19,3.55507480263283e-18,"down","yes","ZNF850","protein_coding","chr19:36714383-36772825:-","gi|302148470|ref|NP_001180481.1|",5736,0,"zinc finger protein 850 isoform 1 [Homo sapiens]","gi|302148469|ref|NM_001193552.1|",7714,0,"Homo sapiens zinc finger protein 850 (ZNF850), transcript variant 1, mRNA","A8MQ14",2214,0,"Zinc finger protein 850",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000010292",3945,3766,3504,6485.02917013406,7756,9763,12223,0.449991110390889,-1.1520315937154,1.57884796446066e-267,4.614063566442e-265,"down","yes","NCAPD2","protein_coding","chr12:6493356-6531955:+","gi|178056552|ref|NP_055680.3|",6998,0,"condensin complex subunit 1 [Homo sapiens]","gi|961451|dbj|D63880.1|",5523,0,"Homo sapiens mRNA for KIAA0159 gene","Q15021",2700,0,"Condensin complex subunit 1","YLR272c",284,2e-77,"COG5098","pfam12717","Cnd1","non-SMC mitotic condensation complex subunit 1. The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.","GO:0051301|cell division;GO:0051304|chromosome separation;GO:0010032|meiotic chromosome condensation;GO:0007076|mitotic chromosome condensation;","GO:0000793|condensed chromosome;GO:0000779|condensed chromosome, centromeric region;GO:0000796|condensin complex;GO:0000797|condensin core heterodimer;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0000799|nuclear condensin complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K06677","YCS4, CNAP1, CAPD2; condensin complex subunit 1"]
["ENSG00000111087",11,12,8,17.8882268250911,18,35,29,0.449699970066381,-1.15296530691131,0.0164515619126019,0.0415609333556341,"down","yes","GLI1","protein_coding","chr12:57460135-57472262:+","gi|4885279|ref|NP_005260.1|",4929,0,"zinc finger protein GLI1 isoform 1 [Homo sapiens]","gi|224809486|ref|NM_005269.2|",3600,0,"Homo sapiens GLI family zinc finger 1 (GLI1), transcript variant 1, mRNA","P08151",1903,0,"Zinc finger protein GLI1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0060070|canonical Wnt signaling pathway;GO:0021696|cerebellar cortex morphogenesis;GO:0048546|digestive tract morphogenesis;GO:0009953|dorsal/ventral pattern formation;GO:0009913|epidermal cell differentiation;GO:0097421|liver regeneration;GO:0030324|lung development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0060032|notochord regression;GO:0001649|osteoblast differentiation;GO:0021983|pituitary gland development;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0045740|positive regulation of DNA replication;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0030850|prostate gland development;GO:0009954|proximal/distal pattern formation;GO:2000345|regulation of hepatocyte proliferation;GO:0045667|regulation of osteoblast differentiation;GO:0008589|regulation of smoothened signaling pathway;GO:0009611|response to wounding;GO:0007224|smoothened signaling pathway;GO:0021938|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;GO:0007418|ventral midline development;","GO:0005930|axoneme;GO:0097546|ciliary base;GO:0097542|ciliary tip;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0008017|microtubule binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0044212|transcription regulatory region DNA binding;","K16797","GLI1; zinc finger protein GLI1"]
["ENSG00000137700",358,357,317,596.694871810276,684,932,1128,0.449607994478482,-1.153260406544,2.5565098344913e-40,6.04288746172405e-39,"down","yes","SLC37A4","protein_coding","chr11:119024114-119030906:-","gi|62087632|dbj|BAD92263.1|",626,5e-99,"solute carrier family 37 (glycerol-6-phosphate transporter), member 4 variant [Homo sapiens]","gi|62087631|dbj|AB209026.1|",5840,0,"Homo sapiens mRNA for solute carrier family 37 (glycerol-6-phosphate transporter), member 4 variant protein","O43826",180,1e-66,"Glucose-6-phosphate exchanger SLC37A4","CT544",75.9,5e-13,"COG2271","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0008643|carbohydrate transport;GO:0006094|gluconeogenesis;GO:0042593|glucose homeostasis;GO:0006006|glucose metabolic process;GO:0015760|glucose-6-phosphate transport;GO:0035435|phosphate ion transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0061513|glucose 6-phosphate:inorganic phosphate antiporter activity;GO:0015152|glucose-6-phosphate transmembrane transporter activity;GO:0005215|transporter activity;","K08171","SLC37A4; MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4"]
["ENSG00000149564",504,464,431,808.314683266758,948,1185,1591,0.449590118549351,-1.15331776768375,1.32250684852332e-51,3.96710919040711e-50,"down","yes","ESAM","protein_coding","chr11:124752583-124762290:-","gi|602706739|ref|XP_007463649.1|",853,7e-103,"PREDICTED: endothelial cell-selective adhesion molecule isoform X1 [Lipotes vexillifer]","gi|37779131|gb|AY189281.1|",2279,0,"Homo sapiens LP4791 protein mRNA, complete cds","Q96AP7",323,1e-100,"Endothelial cell-selective adhesion molecule",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050900|leukocyte migration;","GO:0005912|adherens junction;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K06787","ESAM; endothelial cell adhesion molecule"]
["ENSG00000085552",35,35,28,56.7366906423093,76,74,109,0.449246853853013,-1.15441969453901,1.78009012123009e-05,7.54270172633701e-05,"down","yes","IGSF9","protein_coding","chr1:159927039-159945604:-","gi|686701561|ref|XP_009240422.1|",1442,2e-173,"PREDICTED: LOW QUALITY PROTEIN: protein turtle homolog A [Pongo abelii]","gi|16552110|dbj|AK056650.1|",4178,0,"Homo sapiens cDNA FLJ32088 fis, clone OCBBF2000703, weakly similar to TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 PRECURSOR (EC 2.7.1.112)","Q9P2J2",548,4e-170,"Protein turtle homolog A",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0016358|dendrite development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050807|regulation of synapse organization;","GO:0030424|axon;GO:0030054|cell junction;GO:0030425|dendrite;GO:0060077|inhibitory synapse;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0098632|protein binding involved in cell-cell adhesion;",".","."]
["ENSG00000186076",110,153,127,227.015727913257,293,345,392,0.449238138297322,-1.15444768362972,6.4706251762845e-15,6.00603553417592e-14,"down","yes","AC012085.1","processed_pseudogene","chr12:93640822-93641586:-","gi|641706816|ref|XP_008142352.1|",1290,4e-178,"PREDICTED: phosphoglycerate mutase 1 [Eptesicus fuscus]","gi|299829271|ref|NG_006124.4|",765,0,"Homo sapiens phosphoglycerate mutase 1 (brain) pseudogene (LOC642969) on chromosome 12","P18669",501,8e-180,"Phosphoglycerate mutase 1","gpmA",293,2e-98,"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0061621|canonical glycolysis;GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0043312|neutrophil degranulation;GO:0006110|regulation of glycolytic process;GO:0043456|regulation of pentose-phosphate shunt;GO:0045730|respiratory burst;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0016020|membrane;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0034774|secretory granule lumen;","GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0004082|bisphosphoglycerate mutase activity;GO:0016787|hydrolase activity;GO:0004619|phosphoglycerate mutase activity;GO:0019901|protein kinase binding;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["ENSG00000120802",2470,2312,2142,4018.81883553092,4920,6131,7346,0.447572154785804,-1.15980781148199,8.6319653461999e-210,1.71642626389179e-207,"down","yes","TMPO","protein_coding","chr12:98515512-98550379:+","gi|73760405|ref|NP_001027454.1|",2103,0,"thymopoietin isoform beta [Homo sapiens]","gi|296434314|ref|NM_001032283.2|",4181,0,"Homo sapiens thymopoietin (TMPO), transcript variant 2, mRNA","P42167",814,0,"Lamina-associated polypeptide 2, isoforms beta/gamma",".",".",".",".","pfam08198","Thymopoietin","Thymopoietin protein. Short protein of 49 amino acid isolated from bovine spleen cells. Thymopoietins (TMPOs) are a group of ubiquitously expressed nuclear proteins. They are suggested to play an important role in nuclear envelope organisation and cell cycle control.",".","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0031965|nuclear membrane;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0005521|lamin binding;",".","."]
["ENSG00000185551",1167,1140,1151,2013.28455008903,2500,3001,3716,0.446791668265784,-1.16232581207354,9.43168125393958e-113,7.36511206582941e-111,"down","yes","NR2F2","protein_coding","chr15:96325938-96340263:+","gi|635141277|ref|XP_007988707.1|",1896,0,"PREDICTED: COUP transcription factor 2 isoform X1 [Chlorocebus sabaeus]","gi|223555947|ref|NM_021005.3|",5110,0,"Homo sapiens nuclear receptor subfamily 2 group F member 2 (NR2F2), transcript variant 1, mRNA","O09018",734,0,"COUP transcription factor 2",".",".",".",".","pfam00104","Hormone_recep","Ligand-binding domain of nuclear hormone receptor. This all helical domain is involved in binding the hormone in these receptors.","GO:0009952|anterior/posterior pattern specification;GO:0048514|blood vessel morphogenesis;GO:0009566|fertilization;GO:0030900|forebrain development;GO:0060173|limb development;GO:0001893|maternal placenta development;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0010596|negative regulation of endothelial cell migration;GO:0001937|negative regulation of endothelial cell proliferation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001764|neuron migration;GO:0060674|placenta blood vessel development;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0045893|positive regulation of transcription, DNA-templated;GO:0009956|radial pattern formation;GO:0060849|regulation of transcription involved in lymphatic endothelial cell fate commitment;GO:0006355|regulation of transcription, DNA-templated;GO:0032355|response to estradiol;GO:0007519|skeletal muscle tissue development;GO:0006351|transcription, DNA-templated;GO:0060707|trophoblast giant cell differentiation;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0042803|protein homodimerization activity;GO:0001972|retinoic acid binding;GO:0043565|sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0008270|zinc ion binding;","K08548","NR2F2, TFCOUP2; COUP transcription factor 2"]
["ENSG00000100629",133,110,117,209.683533958059,271,326,356,0.446313711543539,-1.16386996548334,3.76496039665947e-16,3.69372106463723e-15,"down","yes","CEP128","protein_coding","chr14:80476983-80959517:-","gi|64085252|ref|NP_689659.2|",5086,0,"centrosomal protein of 128 kDa [Homo sapiens]","gi|767979863|ref|XM_006720056.2|",4638,0,"PREDICTED: Homo sapiens centrosomal protein 128kDa (CEP128), transcript variant X4, mRNA","Q6ZU80",1963,0,"Centrosomal protein of 128 kDa",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0008104|protein localization;","GO:0005814|centriole;GO:0000922|spindle pole;",".","K16460","CEP128; centrosomal protein CEP128"]
["ENSG00000005189",60,56,64,104.833727164176,119,167,197,0.446179182857725,-1.16430489078206,4.29847649597731e-09,2.61295350313301e-08,"down","yes","REXO5","protein_coding","chr16:20806429-20849668:+","gi|222136613|ref|NP_112203.2|",4114,0,"putative RNA exonuclease NEF-sp isoform 1 [Homo sapiens]","gi|222136612|ref|NM_030941.2|",2722,0,"Homo sapiens exonuclease NEF-sp (LOC81691), transcript variant 1, mRNA","Q96IC2",1589,0,"RNA exonuclease 5","SPAC637.09",131,6e-31,"COG0847","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;",".","GO:0070062|extracellular exosome;GO:0005730|nucleolus;","GO:0004527|exonuclease activity;GO:0003723|RNA binding;","K14570","REX1, REXO1, RNH70; RNA exonuclease 1 [EC:3.1.-.-]"]
["ENSG00000138180",1550,1440,1308,2500.07460027689,3055,3771,4648,0.445829179633631,-1.16543705044074,3.3744903016121e-147,3.74064189295944e-145,"down","yes","CEP55","protein_coding","chr10:93496632-93529092:+","gi|187608537|ref|NP_060601.3|",2220,0,"centrosomal protein of 55 kDa [Homo sapiens]","gi|187608536|ref|NM_018131.4|",2635,0,"Homo sapiens centrosomal protein 55kDa (CEP55), transcript variant 1, mRNA","Q53EZ4",859,0,"Centrosomal protein of 55 kDa",".",".",".",".","pfam12180","EABR","TSG101 and ALIX binding domain of CEP55. This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.","GO:0000920|cell separation after cytokinesis;GO:0045184|establishment of protein localization;GO:0000281|mitotic cytokinesis;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0072001|renal system development;","GO:0005814|centriole;GO:0005813|centrosome;GO:0032154|cleavage furrow;GO:0090543|Flemming body;GO:0045171|intercellular bridge;GO:0016020|membrane;GO:0005815|microtubule organizing center;GO:0030496|midbody;GO:0005886|plasma membrane;",".","K16456","CEP55; centrosomal protein CEP55"]
["ENSG00000183655",204,167,158,307.516430725559,391,422,601,0.445323799577742,-1.16707337864828,8.07686768998017e-22,1.04624999331321e-20,"down","yes","KLHL25","protein_coding","chr15:85759323-85795030:-","gi|685552203|ref|XP_009209131.1|",314,3e-42,"PREDICTED: uncharacterized protein LOC103885989 [Papio anubis]","gi|29124203|gb|AC021739.16|",5143,0,"Homo sapiens chromosome 15, clone RP11-158M2, complete sequence",".",".",".",".",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSG00000138030",60,76,53,110.218285833388,139,161,205,0.445295025270291,-1.16716660046107,3.21353719470475e-09,1.98281207330343e-08,"down","yes","KHK","protein_coding","chr2:27086747-27100772:+","gi|4557693|ref|NP_000212.1|",1581,0,"ketohexokinase isoform a [Homo sapiens]","gi|153218446|ref|NM_000221.2|",2408,0,"Homo sapiens ketohexokinase (KHK), transcript variant a, mRNA","P50053",559,0,"Ketohexokinase","APE0012",77.8,1e-14,"COG0524","pfam00294","PfkB","pfkB family carbohydrate kinase. This family includes a variety of carbohydrate and pyrimidine kinases.","GO:0061624|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0009750|response to fructose;GO:0009749|response to glucose;GO:0032868|response to insulin;GO:0009744|response to sucrose;GO:0010043|response to zinc ion;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0005524|ATP binding;GO:0004454|ketohexokinase activity;","K00846","KHK; ketohexokinase [EC:2.7.1.3]"]
["ENSG00000163701",31,21,25,44.6962129800128,45,81,81,0.445022447956233,-1.16804998411547,0.000157183221828459,0.000583814747280439,"down","yes","IL17RE","protein_coding","chr3:9902612-9916402:+","gi|18676788|dbj|BAB85028.1|",1974,0,"unnamed protein product [Homo sapiens]","gi|542133182|ref|NR_104198.1|",2808,0,"Homo sapiens interleukin 17 receptor E (IL17RE), transcript variant 4, non-coding RNA","Q8NFR9",711,0,"Interleukin-17 receptor E",".",".",".",".","pfam15037","IL17_R_N","Interleukin-17 receptor extracellular region. This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.","GO:0006954|inflammatory response;GO:0097400|interleukin-17-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0030368|interleukin-17 receptor activity;","K05168","IL17RE; interleukin 17 receptor E"]
["ENSG00000233276",2046,2056,1919,3514.81450778537,4552,4890,6662,0.44478936741524,-1.1688057936979,2.41822491800178e-115,1.93538266466466e-113,"down","yes","GPX1","polymorphic_pseudogene","chr3:49357171-49358600:-","gi|41406084|ref|NP_000572.2|",958,2e-126,"glutathione peroxidase 1 isoform 1 [Homo sapiens]","gi|931568087|ref|XM_003818370.3|",1094,0,"PREDICTED: Pan paniscus glutathione peroxidase 1 (GPX1), mRNA","P07203",373,6e-128,"Glutathione peroxidase 1","slr1171",109,3e-27,"COG0386","pfam00255","GSHPx","Glutathione peroxidase.","GO:0060055|angiogenesis involved in wound healing;GO:0043534|blood vessel endothelial cell migration;GO:0045454|cell redox homeostasis;GO:0034599|cellular response to oxidative stress;GO:0001885|endothelial cell development;GO:0045444|fat cell differentiation;GO:0006749|glutathione metabolic process;GO:0060047|heart contraction;GO:0042744|hydrogen peroxide catabolic process;GO:0051702|interaction with symbiont;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0019372|lipoxygenase pathway;GO:0051450|myoblast proliferation;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:1902176|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0051897|positive regulation of protein kinase B signaling;GO:1902905|positive regulation of fibril organization;GO:0018158|protein oxidation;GO:0006195|purine nucleotide catabolic process;GO:0040029|regulation of gene expression, epigenetic;GO:0033599|regulation of mammary gland epithelial cell proliferation;GO:0043523|regulation of neuron apoptotic process;GO:0061136|regulation of proteasomal protein catabolic process;GO:0010332|response to gamma radiation;GO:0042542|response to hydrogen peroxide;GO:0033194|response to hydroperoxide;GO:0010269|response to selenium ion;GO:0009609|response to symbiotic bacterium;GO:0009410|response to xenobiotic stimulus;GO:0007605|sensory perception of sound;GO:0048741|skeletal muscle fiber development;GO:0043403|skeletal muscle tissue regeneration;GO:0001659|temperature homeostasis;GO:0006641|triglyceride metabolic process;GO:0009650|UV protection;GO:0042311|vasodilation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0004602|glutathione peroxidase activity;GO:0017124|SH3 domain binding;","K00432","E1.11.1.9; glutathione peroxidase [EC:1.11.1.9]"]
["ENSG00000198121",186,203,160,319.966472022287,387,471,616,0.444647980828711,-1.16926446058288,1.89953262752289e-23,2.6226331653301e-22,"down","yes","LPAR1","protein_coding","chr9:110873263-111038458:-","gi|16950636|ref|NP_001392.2|",1904,0,"lysophosphatidic acid receptor 1 [Homo sapiens]","gi|23271230|gb|BC036034.1|",3631,0,"Homo sapiens lysophosphatidic acid receptor 1, mRNA (cDNA clone MGC:33157 IMAGE:5272431), complete cds","Q92633",724,0,"Lysophosphatidic acid receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000187|activation of MAPK activity;GO:0007202|activation of phospholipase C activity;GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0032060|bleb assembly;GO:0060326|cell chemotaxis;GO:1904566|cellular response to 1-oleoyl-sn-glycerol 3-phosphate;GO:0071453|cellular response to oxygen levels;GO:0021549|cerebellum development;GO:0022038|corpus callosum development;GO:0007186|G-protein coupled receptor signaling pathway;GO:0042552|myelination;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0010977|negative regulation of neuron projection development;GO:0014003|oligodendrocyte development;GO:0021554|optic nerve development;GO:0043065|positive regulation of apoptotic process;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0060999|positive regulation of dendritic spine development;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0035025|positive regulation of Rho protein signal transduction;GO:0071673|positive regulation of smooth muscle cell chemotaxis;GO:0051496|positive regulation of stress fiber assembly;GO:0008360|regulation of cell shape;","GO:0009986|cell surface;GO:0043198|dendritic shaft;GO:0043197|dendritic spine;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;","GO:0001965|G-protein alpha-subunit binding;GO:0004930|G-protein coupled receptor activity;GO:0035727|lysophosphatidic acid binding;GO:0070915|lysophosphatidic acid receptor activity;GO:0030165|PDZ domain binding;","K04289","LPAR1, EDG2; lysophosphatidic acid receptor 1"]
["ENSG00000081923",137,153,138,249.993756582995,293,395,462,0.444470792720838,-1.16983947579012,3.63782794336295e-19,4.19906794563643e-18,"down","yes","ATP8B1","protein_coding","chr18:57646426-57803315:-","gi|5031697|ref|NP_005594.1|",6364,0,"phospholipid-transporting ATPase IC [Homo sapiens]","gi|767998816|ref|XM_006722481.2|",6150,0,"PREDICTED: Homo sapiens ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1), transcript variant X1, mRNA","O43520",2430,0,"Phospholipid-transporting ATPase IC",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0015721|bile acid and bile salt transport;GO:0008206|bile acid metabolic process;GO:0006855|drug transmembrane transport;GO:0007030|Golgi organization;GO:0060119|inner ear receptor cell development;GO:0034220|ion transmembrane transport;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045332|phospholipid translocation;GO:0032534|regulation of microvillus assembly;GO:0007605|sensory perception of sound;GO:0021650|vestibulocochlear nerve formation;","GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0032420|stereocilium;","GO:0015247|aminophospholipid transporter activity;GO:0005524|ATP binding;GO:1901612|cardiolipin binding;GO:0000287|magnesium ion binding;GO:0004012|phospholipid-translocating ATPase activity;","K01530","E3.6.3.1; phospholipid-translocating ATPase [EC:3.6.3.1]"]
["ENSG00000110200",30,19,22,41.3108456839999,52,59,79,0.44400947800618,-1.17133762163052,0.000191790944164614,0.000702754436278572,"down","yes","ANAPC15","protein_coding","chr11:72106378-72112780:-","gi|119595246|gb|EAW74840.1|",519,2e-59,"chromosome 11 open reading frame 51, isoform CRA_c [Homo sapiens]","gi|164695316|dbj|AK311146.1|",1475,0,"Homo sapiens cDNA, FLJ18188",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000231298",795,744,788,1364.15568526464,1657,2133,2475,0.442302086656579,-1.17689604640617,1.46229940478679e-81,7.28807000504589e-80,"down","yes","MANCR","lincRNA","chr10:4650185-4678154:-","gi|635051317|ref|XP_008000308.1|",293,3e-52,"PREDICTED: uncharacterized protein LOC103237802 [Chlorocebus sabaeus]","gi|551868336|tpe|HG502611.1|",1478,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000046512.2 (RP11-117P22.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000114346",2118,1921,1956,3512.65801046106,4449,5289,6354,0.442233714600897,-1.17711907870339,9.49497402212328e-170,1.30813613527653e-167,"down","yes","ECT2","protein_coding","chr3:172750682-172821474:+","gi|21735572|ref|NP_060568.3|",4478,0,"protein ECT2 isoform b [Homo sapiens]","gi|385198080|ref|NM_001258316.1|",4406,0,"Homo sapiens epithelial cell transforming 2 (ECT2), transcript variant 2, mRNA","Q9H8V3",1713,0,"Protein ECT2","SPCC645.07",62.8,7e-09,"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0090630|activation of GTPase activity;GO:0032147|activation of protein kinase activity;GO:0070830|bicellular tight junction assembly;GO:0000902|cell morphogenesis;GO:0071277|cellular response to calcium ion;GO:0070301|cellular response to hydrogen peroxide;GO:0071479|cellular response to ionizing radiation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0000281|mitotic cytokinesis;GO:0043065|positive regulation of apoptotic process;GO:0032467|positive regulation of cytokinesis;GO:0043547|positive regulation of GTPase activity;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045666|positive regulation of neuron differentiation;GO:0042307|positive regulation of protein import into nucleus;GO:0051260|protein homooligomerization;GO:0015031|protein transport;GO:0051988|regulation of attachment of spindle microtubules to kinetochore;GO:0045859|regulation of protein kinase activity;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005923|bicellular tight junction;GO:0005911|cell-cell junction;GO:0097149|centralspindlin complex;GO:0032154|cleavage furrow;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030496|midbody;GO:0072686|mitotic spindle;GO:0005634|nucleus;","GO:0005096|GTPase activator activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0042803|protein homodimerization activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["ENSG00000121211",158,142,140,258.344668839128,331,373,483,0.440585711371413,-1.18250538711109,8.68311355594657e-21,1.07084331372824e-19,"down","yes","MND1","protein_coding","chr4:153344649-153415118:+","gi|14149769|ref|NP_115493.1|",1079,1e-145,"meiotic nuclear division protein 1 homolog isoform 1 [Homo sapiens]","gi|359718972|ref|NM_032117.3|",945,0,"Homo sapiens meiotic nuclear divisions 1 (MND1), transcript variant 1, mRNA","Q9BWT6",420,4e-147,"Meiotic nuclear division protein 1 homolog","SPAC13A11.03",134,3e-36,"COG5124","pfam03962","Mnd1","Mnd1 family. This family of proteins includes MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.","GO:0006302|double-strand break repair;GO:0007131|reciprocal meiotic recombination;","GO:0005634|nucleus;","GO:0003690|double-stranded DNA binding;",".","."]
["ENSG00000125398",946,953,873,1627.87585618736,1983,2425,3104,0.440391601338937,-1.18314113920534,5.91757078702953e-102,3.99084284406383e-100,"down","yes","SOX9","protein_coding","chr17:72121020-72126420:+","gi|60360276|dbj|BAD90382.1|",2285,0,"mKIAA4243 protein [Mus musculus]","gi|182765453|ref|NM_000346.3|",3935,0,"Homo sapiens SRY-box 9 (SOX9), mRNA","P61754",880,0,"Transcription factor SOX-9",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0019933|cAMP-mediated signaling;GO:0001502|cartilage condensation;GO:0051216|cartilage development;GO:0001708|cell fate specification;GO:0071773|cellular response to BMP stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071504|cellular response to heparin;GO:0071260|cellular response to mechanical stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0002062|chondrocyte differentiation;GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0003415|chondrocyte hypertrophy;GO:0006338|chromatin remodeling;GO:0090103|cochlea morphogenesis;GO:0003203|endocardial cushion morphogenesis;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0060517|epithelial cell proliferation involved in prostatic bud elongation;GO:0001837|epithelial to mesenchymal transition;GO:0070371|ERK1 and ERK2 cascade;GO:0001942|hair follicle development;GO:0003170|heart valve development;GO:0003179|heart valve morphogenesis;GO:0060729|intestinal epithelial structure maintenance;GO:0019100|male germ-line sex determination;GO:0008584|male gonad development;GO:0072289|metanephric nephron tubule formation;GO:0061138|morphogenesis of a branching epithelium;GO:0043066|negative regulation of apoptotic process;GO:0070168|negative regulation of biomineral tissue development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0002683|negative regulation of immune system process;GO:0045662|negative regulation of myoblast differentiation;GO:0030279|negative regulation of ossification;GO:0046533|negative regulation of photoreceptor cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0014036|neural crest cell fate specification;GO:0006334|nucleosome assembly;GO:0030916|otic vesicle formation;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0061036|positive regulation of cartilage development;GO:0008284|positive regulation of cell proliferation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0030858|positive regulation of epithelial cell differentiation;GO:0010634|positive regulation of epithelial cell migration;GO:0050679|positive regulation of epithelial cell proliferation;GO:0090184|positive regulation of kidney development;GO:2000020|positive regulation of male gonad development;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:2000741|positive regulation of mesenchymal stem cell differentiation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0001934|positive regulation of protein phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0043491|protein kinase B signaling;GO:0065003|macromolecular complex assembly;GO:0042981|regulation of apoptotic process;GO:0061035|regulation of cartilage development;GO:0010564|regulation of cell cycle process;GO:0042127|regulation of cell proliferation;GO:0060784|regulation of cell proliferation involved in tissue homeostasis;GO:0072034|renal vesicle induction;GO:0060041|retina development in camera-type eye;GO:0060221|retinal rod cell differentiation;GO:0060008|Sertoli cell differentiation;GO:0007165|signal transduction;GO:0001501|skeletal system development;GO:0035019|somatic stem cell population maintenance;GO:0007283|spermatogenesis;GO:0001894|tissue homeostasis;","GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0035326|enhancer binding;GO:0001158|enhancer sequence-specific DNA binding;GO:0004672|protein kinase activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["ENSG00000141753",10392,10599,9538,17939.4976295427,21725,26608,34573,0.440230226176623,-1.18366989091629,4.7959470180049e-262,1.36035626593057e-259,"down","yes","IGFBP4","protein_coding","chr17:40443461-40457731:+","gi|795356808|ref|XP_011785341.1|",1160,2e-151,"PREDICTED: insulin-like growth factor-binding protein 4, partial [Colobus angolensis palliatus]","gi|62243289|ref|NM_001552.2|",2199,0,"Homo sapiens insulin like growth factor binding protein 4 (IGFBP4), mRNA","P22692",450,2e-152,"Insulin-like growth factor-binding protein 4",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0008283|cell proliferation;GO:0044267|cellular protein metabolic process;GO:0006259|DNA metabolic process;GO:0006954|inflammatory response;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0043410|positive regulation of MAPK cascade;GO:0043687|post-translational protein modification;GO:0001558|regulation of cell growth;GO:0010906|regulation of glucose metabolic process;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;GO:0007165|signal transduction;GO:0001501|skeletal system development;GO:0044342|type B pancreatic cell proliferation;","GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;GO:0005102|receptor binding;",".","."]
["ENSG00000104881",697,651,640,1166.72154566641,1385,1688,2340,0.440219410741286,-1.18370533502183,4.88921352457585e-68,1.93640966041107e-66,"down","yes","PPP1R13L","protein_coding","chr19:45379634-45406349:-","gi|544512097|ref|XP_005589646.1|",3160,0,"PREDICTED: relA-associated inhibitor isoform X1 [Macaca fascicularis]","gi|215820634|ref|NM_001142502.1|",3118,0,"Homo sapiens protein phosphatase 1 regulatory subunit 13 like (PPP1R13L), transcript variant 1, mRNA","Q8WUF5",1220,0,"RelA-associated inhibitor",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006915|apoptotic process;GO:0060048|cardiac muscle contraction;GO:0003215|cardiac right ventricle morphogenesis;GO:0031076|embryonic camera-type eye development;GO:0042633|hair cycle;GO:0035264|multicellular organism growth;GO:0048871|multicellular organismal homeostasis;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045597|positive regulation of cell differentiation;GO:0009791|post-embryonic development;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0006351|transcription, DNA-templated;GO:0003229|ventricular cardiac muscle tissue development;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0045171|intercellular bridge;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0045296|cadherin binding;GO:0042802|identical protein binding;GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;",".","."]
["ENSG00000182575",20,14,10,25.6537202473515,29,42,48,0.439342118829981,-1.18658328060497,0.0030551441388533,0.00911345811169232,"down","yes","NXPH3","protein_coding","chr17:49575858-49583827:+","gi|6330146|dbj|BAA86473.1|",1109,3e-136,"KIAA1159 protein [Homo sapiens]","gi|28191449|gb|AC006487.9|",5194,0,"Homo sapiens chromosome 17, clone RP5-1029K10, complete sequence","O95157",430,8e-137,"Neurexophilin-3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.","GO:0007218|neuropeptide signaling pathway;","GO:0005576|extracellular region;","GO:0005102|receptor binding;","K16658","NXPH3; neurexophilin-3"]
["ENSG00000114646",71,107,69,145.469325549141,181,193,301,0.439177209593116,-1.1871249049798,4.25715317052364e-10,2.84518261791614e-09,"down","yes","CSPG5","protein_coding","chr3:47562239-47580792:-","gi|332635065|ref|NP_001193872.1|",2460,0,"chondroitin sulfate proteoglycan 5 isoform 3 precursor [Homo sapiens]","gi|33317700|gb|AF461089.1|",4158,0,"Homo sapiens chondroitin sulfate proteoglycan 5-III (CSPG5) mRNA, complete cds","O95196",952,0,"Chondroitin sulfate proteoglycan 5",".",".",".",".","pfam06566","Chon_Sulph_att","Chondroitin sulphate attachment domain. This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation.","GO:0030154|cell differentiation;GO:0030206|chondroitin sulfate biosynthetic process;GO:0030207|chondroitin sulfate catabolic process;GO:0030208|dermatan sulfate biosynthetic process;GO:0046907|intracellular transport;GO:0050804|modulation of synaptic transmission;GO:0007399|nervous system development;GO:0040008|regulation of growth;","GO:0009986|cell surface;GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0005796|Golgi lumen;GO:0000139|Golgi membrane;GO:0030660|Golgi-associated vesicle membrane;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0043202|lysosomal lumen;GO:0016020|membrane;","GO:0008083|growth factor activity;","K08116","CSPG5; chondroitin sulfate proteoglycan 5"]
["ENSG00000125898",168,173,152,289.885525672672,346,434,562,0.439088287990934,-1.18741704159518,4.80816886713581e-23,6.52638712943811e-22,"down","yes","FAM110A","protein_coding","chr20:833715-857463:+","gi|694977642|ref|XP_003316847.2|",979,6e-123,"PREDICTED: protein FAM110A isoform X1 [Pan troglodytes]","gi|574584464|ref|NM_001289145.1|",1856,0,"Homo sapiens family with sequence similarity 110 member A (FAM110A), transcript variant 4, mRNA","Q9BQ89",335,2e-108,"Protein FAM110A",".",".",".",".","pfam14160","FAM110_C","Centrosome-associated C terminus. This is the C-terminus of a family of proteins that colocalize with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.",".","GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0000922|spindle pole;",".",".","."]
["ENSG00000065717",56,35,39,76.1291654429292,90,120,142,0.439082500921982,-1.18743605606431,4.71645400468976e-07,2.37832587823414e-06,"down","yes","TLE2","protein_coding","chr19:2997638-3047635:-","gi|21361151|ref|NP_003251.2|",3293,0,"transducin-like enhancer protein 2 isoform 1 [Homo sapiens]","gi|221219046|ref|NM_003260.4|",2705,0,"Homo sapiens transducin like enhancer of split 2 (TLE2), transcript variant 1, mRNA","Q04725",1273,0,"Transducin-like enhancer protein 2",".",".",".",".","pfam03920","TLE_N","Groucho/TLE N-terminal Q-rich domain. The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.","GO:0009887|organ morphogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0007165|signal transduction;GO:0006351|transcription, DNA-templated;GO:0016055|Wnt signaling pathway;","GO:0005615|extracellular space;GO:0005925|focal adhesion;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003714|transcription corepressor activity;",".","."]
["ENSG00000149548",68,37,48,89.5434114393447,98,150,168,0.438683102160584,-1.18874895930442,1.84574092534794e-07,9.66358603911812e-07,"down","yes","CCDC15","protein_coding","chr11:124954121-125041489:+","gi|144922720|ref|NP_079280.2|",4507,0,"coiled-coil domain-containing protein 15 [Homo sapiens]","gi|144922719|ref|NM_025004.2|",2844,0,"Homo sapiens coiled-coil domain containing 15 (CCDC15), mRNA","Q0P6D6",1740,0,"Coiled-coil domain-containing protein 15",".",".",".",".","pfam01010","Oxidored_q1_C","NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus. This sub-family represents a carboxyl terminal extension of pfam00361. It includes subunit 5 from chloroplasts, and bacterial subunit L. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.",".","GO:0005813|centrosome;",".","K16752","CCDC15; coiled-coil domain-containing protein 15"]
["ENSG00000134333",9342,9054,8221,15674.4104286963,19260,23763,29273,0.438400481418677,-1.18967871232807,0,0,"down","yes","LDHA","protein_coding","chr11:18394388-18408425:+","gi|655884124|ref|XP_008273293.1|",1754,0,"PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Oryctolagus cuniculus]","gi|426367636|ref|XM_004050786.1|",2357,0,"PREDICTED: Gorilla gorilla gorilla lactate dehydrogenase A, transcript variant 1 (LDHA), mRNA","P00338",650,0,"L-lactate dehydrogenase A chain","CAC0267",263,2e-79,"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.","GO:0006096|glycolytic process;GO:0006089|lactate metabolic process;GO:0019674|NAD metabolic process;GO:0043065|positive regulation of apoptotic process;GO:0048569|post-embryonic organ development;GO:0006090|pyruvate metabolic process;GO:0051591|response to cAMP;GO:0043627|response to estrogen;GO:0009749|response to glucose;GO:0042542|response to hydrogen peroxide;GO:0001666|response to hypoxia;GO:0007584|response to nutrient;GO:0021762|substantia nigra development;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0005634|nucleus;","GO:0045296|cadherin binding;GO:0042802|identical protein binding;GO:0019900|kinase binding;GO:0004459|L-lactate dehydrogenase activity;GO:0051287|NAD binding;","K00016","LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]"]
["ENSG00000125885",1224,1103,1147,2047.80188700602,2437,3194,3835,0.437983195248804,-1.19105257802053,1.72195392788941e-118,1.45671260355837e-116,"down","yes","MCM8","protein_coding","chr20:5950652-5998977:+","gi|19923727|ref|NP_115874.3|",4300,0,"DNA helicase MCM8 isoform 1 [Homo sapiens]","gi|5123778|emb|AL035461.11|",4682,0,"Human DNA sequence from clone RP5-967N21 on chromosome 20p12.3-13, complete sequence","Q9UJA3",1659,0,"DNA helicase MCM8","SSO0774",318,4e-91,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0006974|cellular response to DNA damage stimulus;GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000724|double-strand break repair via homologous recombination;GO:0007292|female gamete generation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0048232|male gamete generation;","GO:0097362|MCM8-MCM9 complex;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0004386|helicase activity;","K10737","MCM8; DNA helicase MCM8 [EC:3.6.4.12]"]
["ENSG00000101868",553,568,525,971.685804327759,1220,1471,1780,0.437811250090073,-1.19161906809663,2.63733797596962e-67,1.03602800163955e-65,"down","yes","POLA1","protein_coding","chrX:24693919-24996986:+","gi|530421176|ref|XP_005274609.1|",7181,0,"PREDICTED: DNA polymerase alpha catalytic subunit isoform X1 [Homo sapiens]","gi|768032532|ref|XM_005274552.2|",5486,0,"PREDICTED: Homo sapiens polymerase (DNA directed), alpha 1, catalytic subunit (POLA1), transcript variant X1, mRNA","P09884",2754,0,"DNA polymerase alpha catalytic subunit","SPAC3H5.06c",715,0,"COG0417","pfam00136","DNA_pol_B","DNA polymerase family B. This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.","GO:0008283|cell proliferation;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0006269|DNA replication, synthesis of RNA primer;GO:0006271|DNA strand elongation involved in DNA replication;GO:0000731|DNA synthesis involved in DNA repair;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0000082|G1/S transition of mitotic cell cycle;GO:0006273|lagging strand elongation;GO:0006272|leading strand elongation;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0032201|telomere maintenance via semi-conservative replication;GO:0016032|viral process;","GO:0005658|alpha DNA polymerase:primase complex;GO:0005829|cytosol;GO:0005635|nuclear envelope;GO:0016363|nuclear matrix;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0046872|metal ion binding;GO:0001882|nucleoside binding;GO:0000166|nucleotide binding;GO:0019901|protein kinase binding;","K02320","POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"]
["ENSG00000204922",28,31,19,45.7756441316947,54,62,98,0.437590137543487,-1.19234787201613,9.10157047254953e-05,0.00034928589589044,"down","yes","UQCC3","protein_coding","chr11:62670273-62673687:+","gi|332250003|ref|XP_003274143.1|",407,2e-52,"PREDICTED: uncharacterized protein LOC100580979 [Nomascus leucogenys]","gi|305682575|ref|NM_001085372.2|",1837,0,"Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3), mRNA","Q8WTZ3",84.7,1e-16,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000179841",51,47,39,80.6730785061884,100,123,149,0.437518249119708,-1.19258490110715,8.88413893556758e-08,4.81611219194006e-07,"down","yes","AKAP5","protein_coding","chr14:64465499-64474503:+","gi|158187521|ref|NP_004848.3|",2002,0,"A-kinase anchor protein 5 [Homo sapiens]","gi|158187520|ref|NM_004857.3|",6487,0,"Homo sapiens A-kinase anchoring protein 5 (AKAP5), mRNA","P24588",775,0,"A-kinase anchor protein 5",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007268|synaptic transmission;GO:1903078|positive regulation of protein localization to plasma membrane;GO:0006605|protein targeting;GO:0010738|regulation of protein kinase A signaling;GO:0007165|signal transduction;","GO:0009898|cytoplasmic side of plasma membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0008179|adenylate cyclase binding;GO:0005516|calmodulin binding;GO:0035254|glutamate receptor binding;GO:0051018|protein kinase A binding;GO:0034237|protein kinase A regulatory subunit binding;GO:0030346|protein phosphatase 2B binding;GO:0097110|scaffold protein binding;GO:0017124|SH3 domain binding;","K16522","AKAP5; A-kinase anchor protein 5"]
["ENSG00000163485",40,27,33,58.8833963462938,71,92,109,0.437356511872874,-1.19311832037353,5.9180555070772e-06,2.64966236352147e-05,"down","yes","ADORA1","protein_coding","chr1:203090654-203167405:+","gi|4501947|ref|NP_000665.1|",1320,3e-169,"adenosine receptor A1 [Homo sapiens]","gi|34534798|dbj|AK127752.1|",3387,0,"Homo sapiens cDNA FLJ45852 fis, clone OCBBF2018618, highly  similar to Adenosine A1 receptor","P30542",513,1e-170,"Adenosine receptor A1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000186|activation of MAPKK activity;GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0097190|apoptotic signaling pathway;GO:0007267|cell-cell signaling;GO:0050890|cognition;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0060079|excitatory postsynaptic potential;GO:0055089|fatty acid homeostasis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006954|inflammatory response;GO:0016042|lipid catabolic process;GO:0002674|negative regulation of acute inflammatory response;GO:0043066|negative regulation of apoptotic process;GO:0055118|negative regulation of cardiac muscle contraction;GO:0008285|negative regulation of cell proliferation;GO:0042323|negative regulation of circadian sleep/wake cycle, non-REM sleep;GO:0014050|negative regulation of glutamate secretion;GO:0046888|negative regulation of hormone secretion;GO:0002686|negative regulation of leukocyte migration;GO:0050995|negative regulation of lipid catabolic process;GO:1900453|negative regulation of long term synaptic depression;GO:1900272|negative regulation of long-term synaptic potentiation;GO:0070256|negative regulation of mucus secretion;GO:0032900|negative regulation of neurotrophin production;GO:0035814|negative regulation of renal sodium excretion;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0007399|nervous system development;GO:0006909|phagocytosis;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0050996|positive regulation of lipid catabolic process;GO:1901216|positive regulation of neuron death;GO:0032244|positive regulation of nucleoside transport;GO:0002793|positive regulation of peptide secretion;GO:0043268|positive regulation of potassium ion transport;GO:0035307|positive regulation of protein dephosphorylation;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0006612|protein targeting to membrane;GO:0003093|regulation of glomerular filtration;GO:0002087|regulation of respiratory gaseous exchange by neurological system process;GO:0051930|regulation of sensory perception of pain;GO:0060087|relaxation of vascular smooth muscle;GO:0001666|response to hypoxia;GO:0007165|signal transduction;GO:0001659|temperature homeostasis;GO:0070328|triglyceride homeostasis;","GO:0030673|axolemma;GO:0016323|basolateral plasma membrane;GO:0043197|dendritic spine;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0048786|presynaptic active zone;GO:0043195|terminal bouton;","GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0001609|G-protein coupled adenosine receptor activity;GO:0001664|G-protein coupled receptor binding;GO:0031072|heat shock protein binding;GO:0032795|heterotrimeric G-protein binding;GO:0004629|phospholipase C activity;GO:0046982|protein heterodimerization activity;GO:0001883|purine nucleoside binding;","K04265","ADORA1; adenosine A1 receptor"]
["ENSG00000182378",33,39,44,68.8789173140371,86,109,121,0.437089211973474,-1.19400032423218,1.39725181545708e-06,6.69403701354597e-06,"down","yes","PLCXD1","protein_coding","chrX:276322-303356:+","gi|8922995|ref|NP_060860.1|",1734,0,"PI-PLC X domain-containing protein 1 [Homo sapiens]","gi|254039597|ref|NM_018390.3|",5305,0,"Homo sapiens phosphatidylinositol specific phospholipase C X domain containing 1 (PLCXD1), transcript variant 1, mRNA","Q9NUJ7",672,0,"PI-PLC X domain-containing protein 1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006629|lipid metabolic process;","GO:0005737|cytoplasm;","GO:0008081|phosphoric diester hydrolase activity;",".","."]
["ENSG00000132561",41,48,39,75.4007119772727,76,119,160,0.436575038773795,-1.19569844844945,6.88343791020048e-07,3.41217554386911e-06,"down","yes","MATN2","protein_coding","chr8:97868840-98036716:+","gi|21739491|emb|CAD38787.1|",4988,0,"hypothetical protein [Homo sapiens]","gi|960139574|ref|NM_002380.4|",4103,0,"Homo sapiens matrilin 2 (MATN2), transcript variant 1, mRNA","O00339",1915,0,"Matrilin-2",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007411|axon guidance;GO:0031104|dendrite regeneration;GO:0008347|glial cell migration;GO:0001764|neuron migration;GO:0048678|response to axon injury;","GO:0005604|basement membrane;GO:0031012|extracellular matrix;","GO:0005509|calcium ion binding;",".","."]
["ENSG00000087586",1799,1694,1545,2978.04490792768,3668,4540,5549,0.435810021806899,-1.19822872210295,1.39369654757402e-179,2.06781684689289e-177,"down","yes","AURKA","protein_coding","chr20:56369389-56392337:-","gi|426392209|ref|XP_004062449.1|",2153,0,"PREDICTED: aurora kinase A isoform 3 [Gorilla gorilla gorilla]","gi|38327561|ref|NM_003600.2|",2248,0,"Homo sapiens aurora kinase A (AURKA), transcript variant 2, mRNA","O14965",830,0,"Aurora kinase A",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0009948|anterior/posterior axis specification;GO:0051301|cell division;GO:0051642|centrosome localization;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0000086|G2/M transition of mitotic cell cycle;GO:0097421|liver regeneration;GO:0000278|mitotic cell cycle;GO:0007100|mitotic centrosome separation;GO:0007052|mitotic spindle organization;GO:0043066|negative regulation of apoptotic process;GO:0010972|negative regulation of G2/M transition of mitotic cell cycle;GO:0032091|negative regulation of protein binding;GO:1990138|neuron projection extension;GO:0045840|positive regulation of mitotic nuclear division;GO:1900195|positive regulation of oocyte maturation;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0046777|protein autophosphorylation;GO:0071539|protein localization to centrosome;GO:0006468|protein phosphorylation;GO:0046605|regulation of centrosome cycle;GO:0032465|regulation of cytokinesis;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0031647|regulation of protein stability;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0009611|response to wounding;GO:0007057|spindle assembly involved in female meiosis I;GO:0007051|spindle organization;","GO:0043203|axon hillock;GO:0005814|centriole;GO:0005813|centrosome;GO:0032133|chromosome passenger complex;GO:0005929|cilium;GO:0000780|condensed nuclear chromosome, centromeric region;GO:0005829|cytosol;GO:0042585|germinal vesicle;GO:0072687|meiotic spindle;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;GO:0097431|mitotic spindle pole;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0045120|pronucleus;GO:0005819|spindle;GO:0051233|spindle midzone;GO:0031616|spindle pole centrosome;","GO:0005524|ATP binding;GO:0035174|histone serine kinase activity;GO:0046982|protein heterodimerization activity;GO:0004672|protein kinase activity;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0031625|ubiquitin protein ligase binding;","K11481","AURKA; aurora kinase A [EC:2.7.11.1]"]
["ENSG00000003249",171,131,128,253.991995709625,354,337,474,0.43575967965938,-1.19839538316639,1.17817517432573e-17,1.25550512499418e-16,"down","yes","DBNDD1","protein_coding","chr16:90004865-90020128:-","gi|119587068|gb|EAW66664.1|",278,1e-25,"hypothetical protein MGC3101, isoform CRA_b [Homo sapiens]","gi|40714623|gb|AC092143.4|",2889,0,"Homo sapiens chromosome 16 clone RP11-566K11, complete sequence","Q9H9R9",111,3e-26,"Dysbindin domain-containing protein 1",".",".",".",".","pfam04440","Dysbindin","Dysbindin (Dystrobrevin binding protein 1). Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.","GO:0031175|neuron projection development;","GO:0030672|synaptic vesicle membrane;",".",".","."]
["ENSG00000011332",138,134,110,225.908066265979,288,342,410,0.435570076473881,-1.19902325011997,1.07179967369702e-18,1.20261036103945e-17,"down","yes","DPF1","protein_coding","chr19:38211006-38229714:-","gi|585420398|ref|NP_001276907.1|",2126,0,"zinc finger protein neuro-d4 isoform d [Homo sapiens]","gi|585420397|ref|NM_001289978.1|",2356,0,"Homo sapiens double PHD fingers 1 (DPF1), transcript variant 4, mRNA","P56163",758,0,"Zinc finger protein neuro-d4",".",".",".",".","pfam14051","Requiem_N","N-terminal domain of DPF2/REQ. This putative domain has been detected on the human DPF2 protein and was subsequently targeted for structure determination by the Joint Center for Structural Genomics (JCSG). Possibly, the C-terminus extends by 30 amino acids and forms a separate domain. DPF2 interacts with estrogen related receptor alpha (Err-alpha), an orphan receptor which acts as a regulator in energy metabolizm. It was also identified as an adaptor molecule that links nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa-B) dimer RelB/p52 and switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling factor.","GO:0007399|nervous system development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0071565|nBAF complex;","GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;",".","."]
["ENSG00000170629",58,54,60,102.127923099863,139,139,191,0.435312921576391,-1.19987525000276,3.61707107736814e-09,2.21831691384028e-08,"down","yes","DPY19L2P2","transcribed_unprocessed_pseudogene","chr7:103175133-103280410:-","gi|694923629|ref|XP_009452277.1|",2897,0,"PREDICTED: LOW QUALITY PROTEIN: probable C-mannosyltransferase DPY19L2 [Pan troglodytes]","gi|63100322|gb|BC094802.1|",4071,0,"Homo sapiens cDNA clone IMAGE:5271477, containing frame-shift errors","Q6NUT2",1038,0,"Probable C-mannosyltransferase DPY19L2",".",".",".",".","pfam10034","Dpy19","Q-cell neuroblast polarisation. Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant.","GO:0007275|multicellular organismal development;GO:0018406|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;GO:0007286|spermatid development;","GO:0016021|integral component of membrane;GO:0005637|nuclear inner membrane;GO:0005634|nucleus;","GO:0000030|mannosyltransferase activity;",".","."]
["ENSG00000248527",1367,1299,1132,2245.577704662,2555,3347,4602,0.434683170158717,-1.20196385572084,5.17145255364471e-86,2.79403296511762e-84,"down","yes","MTATP6P1","unprocessed_pseudogene","chr1:633696-634376:+","gi|29690846|gb|AAO88701.1|",639,2e-80,"ATP synthase F0 subunit 6 [Homo sapiens]","gi|953266836|ref|NG_045727.1|",681,0,"Homo sapiens mitochondrially encoded ATP synthase 6 pseudogene 1 (MTATP6P1) on chromosome 1","P00846",245,1e-79,"ATP synthase subunit a","RP023",68.2,4e-13,"COG0356","pfam00119","ATP-synt_A","ATP synthase A chain.","GO:0007568|aging;GO:0006754|ATP biosynthetic process;GO:0042407|cristae formation;GO:0042776|mitochondrial ATP synthesis coupled proton transport;GO:0055093|response to hyperoxia;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005753|mitochondrial proton-transporting ATP synthase complex;GO:0045263|proton-transporting ATP synthase complex, coupling factor F(o);","GO:0015078|hydrogen ion transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K02126","ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a"]
["ENSG00000164056",487,474,425,821.968450725246,1045,1231,1515,0.434291990149103,-1.20326275015158,2.14235700630915e-60,7.48583006117589e-59,"down","yes","SPRY1","protein_coding","chr4:123396795-123403760:+","gi|426345421|ref|XP_004040413.1|",1507,0,"PREDICTED: protein sprouty homolog 1 isoform 3 [Gorilla gorilla gorilla]","gi|384475543|ref|NM_001258038.1|",2608,0,"Homo sapiens sprouty RTK signaling antagonist 1 (SPRY1), transcript variant 1, mRNA","O43609",552,0,"Protein sprouty homolog 1",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.","GO:0060449|bud elongation involved in lung branching;GO:0060940|epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:0000132|establishment of mitotic spindle orientation;GO:0001656|metanephros development;GO:0008285|negative regulation of cell proliferation;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0034260|negative regulation of GTPase activity;GO:0043407|negative regulation of MAP kinase activity;GO:0051387|negative regulation of neurotrophin TRK receptor signaling pathway;GO:0046580|negative regulation of Ras protein signal transduction;GO:0001759|organ induction;GO:0001657|ureteric bud development;","GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;",".","K04704","SPRY1; protein sprouty homolog 1"]
["ENSG00000275437",19,14,14,27.7496654667849,30,49,50,0.434235664943153,-1.20344987164377,0.00167015504448519,0.0052474263720525,"down","yes","AL121832.3","sense_intronic","chr20:62402236-62405935:-","gi|119588610|gb|EAW68204.1|",154,1e-08,"hCG2033532 [Homo sapiens]","gi|666671486|tpe|LK937960.1|",3700,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000474194.1 (RP5-908M14.10 gene), sense_intronic",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000106268",293,266,254,482.520843712955,585,720,937,0.432891647986177,-1.20792212876805,5.19188344100688e-38,1.14185915404949e-36,"down","yes","NUDT1","protein_coding","chr7:2242222-2251146:+","gi|605603403|pdb|4C9W|A",567,1e-69,"Chain A, Crystal Structure Of Nudt1 (mth1) With R-crizotinib","gi|41107633|gb|BC065367.1|",466,0,"Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 1, mRNA (cDNA clone MGC:71157 IMAGE:5814797), complete cds","P36639",224,8e-71,"7,8-dihydro-8-oxoguanine triphosphatase","PAE2253",64.7,6e-12,"COG0494","pfam00293","NUDIX","NUDIX domain.","GO:0007568|aging;GO:0046061|dATP catabolic process;GO:0006203|dGTP catabolic process;GO:0042262|DNA protection;GO:0006281|DNA repair;GO:0008584|male gonad development;GO:0034656|nucleobase-containing small molecule catabolic process;GO:0006195|purine nucleotide catabolic process;GO:0046686|response to cadmium ion;GO:0006979|response to oxidative stress;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0031965|nuclear membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0044714|2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity;GO:0044713|2-hydroxy-adenosine triphosphate pyrophosphatase activity;GO:0035539|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0008413|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0047693|ATP diphosphatase activity;GO:0036219|GTP diphosphatase activity;GO:0003924|GTPase activity;GO:0046872|metal ion binding;GO:0030515|snoRNA binding;","K17816","NUDT1, MTH1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]"]
["ENSG00000071991",29,28,20,45.722203696791,66,57,87,0.432823670583921,-1.208148694382,7.68914414476031e-05,0.000297330016568037,"down","yes","CDH19","protein_coding","chr18:66501083-66604138:-","gi|12656655|ref|NP_066976.1|",3870,0,"cadherin-19 isoform 1 preproprotein [Homo sapiens]","gi|402534572|ref|NM_021153.3|",6237,0,"Homo sapiens cadherin 19 (CDH19), transcript variant 1, mRNA","Q9H159",1495,0,"Cadherin-19",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K06806","CDH19; cadherin 19, type 2"]
["ENSG00000165215",33,48,31,66.8908226512036,101,87,116,0.43282074708844,-1.20815843905856,5.25962057994305e-06,2.36916304871419e-05,"down","yes","CLDN3","protein_coding","chr7:73768997-73770270:-","gi|4502875|ref|NP_001297.1|",812,1e-103,"claudin-3 [Homo sapiens]","gi|237649062|ref|NG_012023.1|",1274,0,"Homo sapiens claudin 3 (CLDN3), RefSeqGene on chromosome 7","O15551",317,5e-105,"Claudin-3",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0070830|bicellular tight junction assembly;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0003382|epithelial cell morphogenesis;GO:0051291|protein heterooligomerization;GO:0051260|protein homooligomerization;GO:0045471|response to ethanol;GO:0001666|response to hypoxia;","GO:0016327|apicolateral plasma membrane;GO:0005923|bicellular tight junction;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0016328|lateral plasma membrane;","GO:0042802|identical protein binding;GO:0005198|structural molecule activity;GO:0004888|transmembrane signaling receptor activity;","K06087","CLDN; claudin"]
["ENSG00000172345",17,17,15,29.3598006171535,49,40,42,0.432270301909302,-1.20999437213939,0.00175032487974587,0.00547522969194587,"down","yes","STARD5","protein_coding","chr15:81309053-81324183:-","gi|158430625|pdb|2R55|A",1117,1e-137,"Chain A, Human Star-Related Lipid Transfer Protein 5","gi|345525588|ref|NG_029933.1|",4353,0,"Homo sapiens interleukin 16 (IL16), RefSeqGene on chromosome 15","Q9NSY2",433,6e-139,"StAR-related lipid transfer protein 5",".",".",".",".","pfam01852","START","START domain.","GO:0015721|bile acid and bile salt transport;GO:0070508|cholesterol import;","GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0032052|bile acid binding;GO:0015485|cholesterol binding;GO:0017127|cholesterol transporter activity;",".","."]
["ENSG00000239672",325,322,256,535.768354731764,531,777,1249,0.432090022109401,-1.21059617851535,3.80812772154675e-09,2.32808771769236e-08,"down","yes","NME1","protein_coding","chr17:51153536-51162428:+","gi|35068|emb|CAA35621.1|",556,4e-72,"Nm23 protein [Homo sapiens]","gi|90080839|dbj|AB172839.1|",1386,0,"Macaca fascicularis brain cDNA clone: QflA-19792, similar to human non-metastatic cells 1, protein (NM23A) expressed in(NME1), transcript variant 1, mRNA, RefSeq: NM_198175.1","Q5RC56",158,5e-56,"Nucleoside diphosphate kinase A","BH1654",92,9e-30,"COG0105","pfam00334","NDK","Nucleoside diphosphate kinase.","GO:0030154|cell differentiation;GO:0006241|CTP biosynthetic process;GO:0006897|endocytosis;GO:0006183|GTP biosynthetic process;GO:0007399|nervous system development;GO:0006228|UTP biosynthetic process;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004550|nucleoside diphosphate kinase activity;",".","."]
["ENSG00000106351",252,254,194,415.459183002532,507,582,850,0.431945176638439,-1.21107988067219,9.37186187498129e-28,1.54764102606712e-26,"down","yes","AGFG2","protein_coding","chr7:100539211-100568219:+","gi|91984781|ref|NP_006067.3|",1953,0,"arf-GAP domain and FG repeat-containing protein 2 [Homo sapiens]","gi|91984780|ref|NM_006076.4|",4796,0,"Homo sapiens ArfGAP with FG repeats 2 (AGFG2), mRNA","O95081",756,0,"Arf-GAP domain and FG repeat-containing protein 2","YNL204c",55.5,5e-07,"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.",".","GO:0016020|membrane;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;",".","."]
["ENSG00000183856",1475,1448,1348,2541.783010818,2993,4033,4785,0.431867483633659,-1.21133939831569,6.01837580747591e-138,6.10960171445239e-136,"down","yes","IQGAP3","protein_coding","chr1:156525405-156572604:-","gi|229462887|sp|Q86VI3.2|IQGA3_HUMAN",8000,0,"RecName: Full=Ras GTPase-activating-like protein IQGAP3","gi|145580627|ref|NM_178229.4|",5982,0,"Homo sapiens IQ motif containing GTPase activating protein 3 (IQGAP3), mRNA","Q86VI3",3041,0,"Ras GTPase-activating-like protein IQGAP3","SPAC4F8.13c",301,4e-82,"COG5261","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0000187|activation of MAPK activity;GO:0071310|cellular response to organic substance;GO:0070371|ERK1 and ERK2 cascade;GO:0000082|G1/S transition of mitotic cell cycle;GO:0010629|negative regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0007265|Ras protein signal transduction;GO:0008361|regulation of cell size;GO:0043087|regulation of GTPase activity;","GO:0005911|cell-cell junction;GO:0005829|cytosol;GO:0016328|lateral plasma membrane;","GO:0005516|calmodulin binding;GO:0070856|myosin VI light chain binding;GO:0017048|Rho GTPase binding;","K05767","IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3"]
["ENSG00000151503",1252,1149,1104,2084.92097351123,2524,3195,3961,0.43183173469779,-1.2114588260318,1.39272988694914e-138,1.4213213788082e-136,"down","yes","NCAPD3","protein_coding","chr11:134150119-134225454:-","gi|119588227|gb|EAW67823.1|",5426,0,"KIAA0056 protein, isoform CRA_c [Homo sapiens]","gi|34530786|dbj|AK124878.1|",5522,0,"Homo sapiens cDNA FLJ42888 fis, clone BRHIP3008183","P42695",2092,0,"Condensin-2 complex subunit D3",".",".",".",".","pfam12717","Cnd1","non-SMC mitotic condensation complex subunit 1. The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.","GO:0051301|cell division;GO:0051304|chromosome separation;GO:0010032|meiotic chromosome condensation;GO:0007076|mitotic chromosome condensation;","GO:0000779|condensed chromosome, centromeric region;GO:0016020|membrane;GO:0000799|nuclear condensin complex;GO:0031618|nuclear pericentric heterochromatin;GO:0005654|nucleoplasm;","GO:0003682|chromatin binding;GO:0035064|methylated histone binding;","K11491","NCAPD3; condensin-2 complex subunit D3"]
["ENSG00000263513",113,85,94,173.41476574122,205,269,333,0.431796859363384,-1.21157534480473,7.58370979890512e-15,6.99543733148169e-14,"down","yes","FAM72C","protein_coding","chr1:143955364-143971965:-","gi|565324168|ref|NP_001274314.1|",780,6e-96,"protein FAM72C [Homo sapiens]","gi|565324167|ref|NM_001287385.1|",2297,0,"Homo sapiens family with sequence similarity 72 member C (FAM72C), mRNA","H0Y354",305,2e-97,"Protein FAM72C",".",".",".",".","pfam14976","FAM72","FAM72 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.",".","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSG00000247809",9,18,18,27.0724160124646,35,34,57,0.430803073992127,-1.21489955062879,0.00271292402390814,0.00817863059911538,"down","yes","NR2F2-AS1","antisense","chr15:96110040-96327361:-","gi|982259780|ref|XP_015308919.1|",508,8e-57,"PREDICTED: uncharacterized protein LOC107130332 isoform X1 [Macaca fascicularis]","gi|551880767|tpe|HG507480.1|",1930,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000415468.2 (RP11-327J17.3 gene), antisense",".",".",".",".",".",".",".",".","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.",".",".",".",".","."]
["ENSG00000174442",568,550,571,1009.10588587542,1283,1493,1894,0.430654313047713,-1.21539781480795,1.09588525199892e-68,4.40363223761565e-67,"down","yes","ZWILCH","protein_coding","chr15:66504959-66550128:+","gi|110578655|ref|NP_060445.3|",3153,0,"protein zwilch homolog isoform 1 [Homo sapiens]","gi|568214286|ref|NM_017975.4|",3193,0,"Homo sapiens zwilch kinetochore protein (ZWILCH), transcript variant 1, mRNA","Q9H900",1219,0,"Protein zwilch homolog",".",".",".",".","pfam09817","DUF2352","Uncharacterized conserved protein (DUF2352). Members of this family of uncharacterized proteins have no known function.","GO:0051301|cell division;GO:0007093|mitotic cell cycle checkpoint;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0000776|kinetochore;GO:1990423|RZZ complex;",".","K11579","ZWILCH; protein zwilch"]
["ENSG00000115414",1457,1302,1267,2400.80447410984,2942,3806,4368,0.430472130868501,-1.21600825554465,2.82220722719385e-142,3.00744381205055e-140,"down","yes","FN1","protein_coding","chr2:215360440-215436172:-","gi|34365241|emb|CAE45958.1|",3068,0,"hypothetical protein [Homo sapiens]","gi|34365483|emb|BX641150.1|",7689,0,"Homo sapiens mRNA; cDNA DKFZp686H05109 (from clone DKFZp686H05109)","P02751",1161,0,"Fibronectin",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006953|acute-phase response;GO:0001525|angiogenesis;GO:0007161|calcium-independent cell-matrix adhesion;GO:0007155|cell adhesion;GO:0007044|cell-substrate junction assembly;GO:0044267|cellular protein metabolic process;GO:0019221|cytokine-mediated signaling pathway;GO:0035987|endodermal cell differentiation;GO:0030198|extracellular matrix organization;GO:0033622|integrin activation;GO:0052047|interaction with other organism via secreted substance involved in symbiotic interaction;GO:0051702|interaction with symbiont;GO:0050900|leukocyte migration;GO:2001202|negative regulation of transforming growth factor-beta secretion;GO:0018149|peptide cross-linking;GO:0002576|platelet degranulation;GO:0045773|positive regulation of axon extension;GO:0008284|positive regulation of cell proliferation;GO:0048146|positive regulation of fibroblast proliferation;GO:0010628|positive regulation of gene expression;GO:1904237|positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:0043687|post-translational protein modification;GO:0008360|regulation of cell shape;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0001932|regulation of protein phosphorylation;GO:0009611|response to wounding;GO:0034446|substrate adhesion-dependent cell spreading;GO:0042060|wound healing;","GO:0016324|apical plasma membrane;GO:0005605|basal lamina;GO:0072562|blood microparticle;GO:0005788|endoplasmic reticulum lumen;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005577|fibrinogen complex;GO:0031093|platelet alpha granule lumen;","GO:0051087|chaperone binding;GO:0005518|collagen binding;GO:0019899|enzyme binding;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0005178|integrin binding;GO:0016504|peptidase activator activity;GO:0002020|protease binding;GO:0008022|protein C-terminus binding;GO:0005102|receptor binding;","K05717","FN1; fibronectin 1"]
["ENSG00000173207",1691,1679,1496,2904.91766525445,3678,4253,5541,0.430040116152798,-1.21745684745594,2.72453447575658e-151,3.22397674652718e-149,"down","yes","CKS1B","protein_coding","chr1:154974653-154979249:+","gi|795172270|ref|XP_011842830.1|",264,3e-44,"PREDICTED: cyclin-dependent kinases regulatory subunit 1 isoform X1 [Mandrillus leucophaeus]","gi|334358872|ref|NG_029028.1|",816,0,"Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), RefSeqGene on chromosome 1","P61025",105,3e-26,"Cyclin-dependent kinases regulatory subunit 1",".",".",".",".","pfam01111","CKS","Cyclin-dependent kinase regulatory subunit.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0044772|mitotic cell cycle phase transition;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0007346|regulation of mitotic cell cycle;GO:0006355|regulation of transcription, DNA-templated;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0019005|SCF ubiquitin ligase complex;","GO:0061575|cyclin-dependent protein serine/threonine kinase activator activity;GO:0042393|histone binding;GO:0019901|protein kinase binding;GO:0043130|ubiquitin binding;","K02219","CKS1; cyclin-dependent kinase regulatory subunit CKS1"]
["ENSG00000076248",1052,1040,991,1844.4125695969,2247,2823,3506,0.42896758779204,-1.22105945112114,4.14161478496704e-123,3.68126571301587e-121,"down","yes","UNG","protein_coding","chr12:109097574-109110992:+","gi|6224979|ref|NP_003353.1|",1505,0,"uracil-DNA glycosylase isoform UNG1 precursor [Homo sapiens]","gi|197101678|ref|NM_001131099.1|",2005,0,"Pongo abelii uracil-DNA glycosylase (UNG), mRNA","P13051",496,5e-169,"Uracil-DNA glycosylase","STM2647",244,8e-74,"COG0692","pfam03167","UDG","Uracil DNA glycosylase superfamily.","GO:0006284|base-excision repair;GO:0097510|base-excision repair, AP site formation via deaminated base removal;GO:0045008|depyrimidination;GO:0006281|DNA repair;GO:0043066|negative regulation of apoptotic process;GO:0045830|positive regulation of isotype switching;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0016447|somatic recombination of immunoglobulin gene segments;GO:0016032|viral process;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003684|damaged DNA binding;GO:0043024|ribosomal small subunit binding;GO:0004844|uracil DNA N-glycosylase activity;","K03648","UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]"]
["ENSG00000197467",4150,3975,3699,7069.09858716604,8547,10932,13406,0.428955309254183,-1.22110074664021,0,0,"down","yes","COL13A1","protein_coding","chr10:69801867-69964275:+","gi|767961635|ref|XP_011537594.1|",1433,0,"PREDICTED: collagen alpha-1(XIII) chain isoform X1 [Homo sapiens]","gi|767961634|ref|XM_011539292.1|",3187,0,"PREDICTED: Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant X1, mRNA","Q5TAT6",522,2e-169,"Collagen alpha-1(XIII) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0030154|cell differentiation;GO:0098609|cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0030574|collagen catabolic process;GO:0001958|endochondral ossification;GO:0030198|extracellular matrix organization;GO:0001763|morphogenesis of a branching structure;","GO:0005911|cell-cell junction;GO:0005600|collagen type XIII trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;","GO:0008201|heparin binding;","K16617","COL13A; collagen, type XIII, alpha"]
["ENSG00000107984",801,704,708,1323.85052370108,1737,1903,2484,0.428922524500058,-1.22121101502658,2.03971483392693e-81,1.01136297472449e-79,"down","yes","DKK1","protein_coding","chr10:52314296-52318042:+","gi|7110719|ref|NP_036374.1|",1273,6e-170,"dickkopf-related protein 1 precursor [Homo sapiens]","gi|385398313|gb|JN966744.1|",1790,0,"Homo sapiens dickkopf-like protein 1 (DKK1) mRNA, complete cds","O94907",494,2e-171,"Dickkopf-related protein 1",".",".",".",".","pfam04706","Dickkopf_N","Dickkopf N-terminal cysteine-rich region. Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.","GO:0000904|cell morphogenesis involved in differentiation;GO:0030326|embryonic limb morphogenesis;GO:0001706|endoderm formation;GO:0060325|face morphogenesis;GO:0030900|forebrain development;GO:0001942|hair follicle development;GO:0007611|learning or memory;GO:0060173|limb development;GO:0001707|mesoderm formation;GO:0090647|modulation of age-related behavioral decline;GO:0043066|negative regulation of apoptotic process;GO:0030514|negative regulation of BMP signaling pathway;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1901296|negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment;GO:2000726|negative regulation of cardiac muscle cell differentiation;GO:0042662|negative regulation of mesodermal cell fate specification;GO:0030279|negative regulation of ossification;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0032091|negative regulation of protein binding;GO:0048642|negative regulation of skeletal muscle tissue development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030178|negative regulation of Wnt signaling pathway;GO:0010942|positive regulation of cell death;GO:0010628|positive regulation of gene expression;GO:0090082|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway;GO:0043507|positive regulation of JUN kinase activity;GO:1901216|positive regulation of neuron death;GO:1902949|positive regulation of tau-protein kinase activity;GO:0045813|positive regulation of Wnt signaling pathway, calcium modulating pathway;GO:2000096|positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:1904338|regulation of dopaminergic neuron differentiation;GO:0042663|regulation of endodermal cell fate specification;GO:0002090|regulation of receptor internalization;GO:0050807|regulation of synapse organization;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0032526|response to retinoic acid;GO:0090244|Wnt signaling pathway involved in somitogenesis;","GO:0031901|early endosome membrane;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;","GO:0039706|co-receptor binding;GO:0008083|growth factor activity;GO:0050750|low-density lipoprotein particle receptor binding;GO:0048019|receptor antagonist activity;","K02165","DKK; dickkopf"]
["ENSG00000257167",20,27,21,40.7390691187573,48,63,79,0.428632368844932,-1.22218729338254,0.000113837789324257,0.000431037157535583,"down","yes","TMPO-AS1","antisense","chr12:98512973-98516422:-","gi|62088174|dbj|BAD92534.1|",232,2e-17,"Lamina-associated polypeptide 2, isoforms beta/gamma variant [Homo sapiens]","gi|551875310|tpe|HG505108.1|",3357,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000407972.3 (RP11-181C3.2 gene), antisense","P42167",82.4,6e-15,"Lamina-associated polypeptide 2, isoforms beta/gamma",".",".",".",".","pfam13163","DUF3999","Protein of unknown function (DUF3999). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 440 and 470 amino acids in length. There is a single completely conserved residue D that may be functionally important.",".","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0031965|nuclear membrane;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0005521|lamin binding;",".","."]
["ENSG00000168032",14,15,10,23.3614023200762,33,34,40,0.428554535458294,-1.22244928954852,0.00338098782070154,0.00998354150117749,"down","yes","ENTPD3","protein_coding","chr3:40387156-40428744:+","gi|166197702|ref|NP_001239.2|",2451,0,"ectonucleoside triphosphate diphosphohydrolase 3 isoform 1 [Homo sapiens]","gi|634743274|ref|NM_001291960.1|",2543,0,"Homo sapiens ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), transcript variant 1, mRNA","O75355",948,0,"Ectonucleoside triphosphate diphosphohydrolase 3","SPCC11E10.05c",149,1e-36,"COG5371","pfam01150","GDA1_CD39","GDA1/CD39 (nucleoside phosphatase) family.","GO:0034656|nucleobase-containing small molecule catabolic process;GO:0009134|nucleoside diphosphate catabolic process;GO:0009143|nucleoside triphosphate catabolic process;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0017110|nucleoside-diphosphatase activity;GO:0017111|nucleoside-triphosphatase activity;","K01510","ENTPD1_3_8; apyrase [EC:3.6.1.5]"]
["ENSG00000118193",780,708,714,1318.69901007298,1686,1971,2450,0.428501737288159,-1.22262704137355,1.87602295819548e-92,1.10996106802682e-90,"down","yes","KIF14","protein_coding","chr1:200551497-200620734:-","gi|7661878|ref|NP_055690.1|",8690,0,"kinesin-like protein KIF14 isoform 1 [Homo sapiens]","gi|208610006|ref|NM_014875.2|",7274,0,"Homo sapiens kinesin family member 14 (KIF14), transcript variant 1, mRNA","Q15058",3348,0,"Kinesin-like protein KIF14","SPAC1834.07",215,1e-57,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0032147|activation of protein kinase activity;GO:0051301|cell division;GO:0021846|cell proliferation in forebrain;GO:0021695|cerebellar cortex development;GO:0021685|cerebellar granular layer structural organization;GO:0021693|cerebellar Purkinje cell layer structural organization;GO:0021987|cerebral cortex development;GO:0045184|establishment of protein localization;GO:0021766|hippocampus development;GO:0007018|microtubule-based movement;GO:0007080|mitotic metaphase plate congression;GO:0043066|negative regulation of apoptotic process;GO:0033624|negative regulation of integrin activation;GO:0043524|negative regulation of neuron apoptotic process;GO:0021772|olfactory bulb development;GO:0008284|positive regulation of cell proliferation;GO:0032467|positive regulation of cytokinesis;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030155|regulation of cell adhesion;GO:0001558|regulation of cell growth;GO:1903429|regulation of cell maturation;GO:0030334|regulation of cell migration;GO:2000045|regulation of G1/S transition of mitotic cell cycle;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0031641|regulation of myelination;GO:0043523|regulation of neuron apoptotic process;GO:0032487|regulation of Rap protein signal transduction;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005829|cytosol;GO:0090543|Flemming body;GO:0005871|kinesin complex;GO:0016020|membrane;GO:0005874|microtubule;GO:0030496|midbody;GO:0005634|nucleus;GO:0051233|spindle midzone;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0030165|PDZ domain binding;GO:0019901|protein kinase binding;GO:0015631|tubulin binding;","K17915","KIF14; kinesin family member 14"]
["ENSG00000166451",226,238,220,410.064317842927,514,639,745,0.42848451725564,-1.22268501956256,8.07972812010078e-33,1.56310728164999e-31,"down","yes","CENPN","protein_coding","chr16:81006498-81033114:+","gi|395132493|ref|NP_001094094.2|",1826,0,"centromere protein N isoform 2 [Homo sapiens]","gi|395132492|ref|NM_001100624.2|",2481,0,"Homo sapiens centromere protein N (CENPN), transcript variant 2, mRNA","Q96H22",707,0,"Centromere protein N",".",".",".",".","pfam05238","CENP-N","Kinetochore protein CHL4 like. CHL4 is a protein involved in chromosome segregation. It is a component of the central kinetochore which mediates the attachment of the centromere to the mitotic spindle. CENP-N is one of the components that assembles onto the CENP-A-nucleosome-associated (NAC) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC.","GO:0034080|CENP-A containing nucleosome assembly;GO:0007059|chromosome segregation;GO:0051382|kinetochore assembly;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K11506","CENPN; centromere protein N"]
["ENSG00000012048",414,379,316,663.459153227755,819,1041,1220,0.42759080496184,-1.22569726563295,1.31359976272493e-48,3.69879010561146e-47,"down","yes","BRCA1","protein_coding","chr17:43044295-43170245:-","gi|237681119|ref|NP_009231.2|",9387,0,"breast cancer type 1 susceptibility protein isoform 2 [Homo sapiens]","gi|237681118|ref|NM_007300.3|",7270,0,"Homo sapiens breast cancer 1 (BRCA1), transcript variant 2, mRNA","P38398",3559,0,"Breast cancer type 1 susceptibility protein",".",".",".",".","pfam04873","EIN3","Ethylene insensitive 3. Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence.","GO:0030521|androgen receptor signaling pathway;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0071681|cellular response to indole-3-methanol;GO:0071356|cellular response to tumor necrosis factor;GO:0007098|centrosome cycle;GO:0043009|chordate embryonic development;GO:0007059|chromosome segregation;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0000729|DNA double-strand break processing;GO:0006260|DNA replication;GO:0009048|dosage compensation by inactivation of X chromosome;GO:0006302|double-strand break repair;GO:0000724|double-strand break repair via homologous recombination;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0006633|fatty acid biosynthetic process;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0044818|mitotic G2/M transition checkpoint;GO:0046600|negative regulation of centriole replication;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0070317|negative regulation of G0 to G1 transition;GO:0035067|negative regulation of histone acetylation;GO:0051572|negative regulation of histone H3-K4 methylation;GO:0051573|negative regulation of histone H3-K9 methylation;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045766|positive regulation of angiogenesis;GO:0071158|positive regulation of cell cycle arrest;GO:0045739|positive regulation of DNA repair;GO:0010628|positive regulation of gene expression;GO:0035066|positive regulation of histone acetylation;GO:0051571|positive regulation of histone H3-K4 methylation;GO:2000617|positive regulation of histone H3-K9 acetylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:2000620|positive regulation of histone H4-K16 acetylation;GO:0070512|positive regulation of histone H4-K20 methylation;GO:0031398|positive regulation of protein ubiquitination;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0006301|postreplication repair;GO:0051865|protein autoubiquitination;GO:0016579|protein deubiquitination;GO:0085020|protein K6-linked ubiquitination;GO:0016567|protein ubiquitination;GO:0042981|regulation of apoptotic process;GO:0042127|regulation of cell proliferation;GO:0044030|regulation of DNA methylation;GO:0006349|regulation of gene expression by genetic imprinting;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006359|regulation of transcription from RNA polymerase III promoter;GO:0043627|response to estrogen;GO:0010212|response to ionizing radiation;GO:0072425|signal transduction involved in G2 DNA damage checkpoint;","GO:0070531|BRCA1-A complex;GO:0031436|BRCA1-BARD1 complex;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0008274|gamma-tubulin ring complex;GO:0000800|lateral element;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0000151|ubiquitin ligase complex;","GO:0050681|androgen receptor binding;GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0019899|enzyme binding;GO:0003723|RNA binding;GO:0070063|RNA polymerase binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0003713|transcription coactivator activity;GO:0044212|transcription regulatory region DNA binding;GO:0015631|tubulin binding;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10605","BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"]
["ENSG00000232803",101,92,94,172.523092304723,226,234,343,0.426070010752946,-1.23083758493565,8.04552236910595e-15,7.41433518658937e-14,"down","yes","SLCO4A1-AS1","antisense","chr20:62663019-62666724:-","gi|355784332|gb|EHH65183.1|",268,2e-22,"Solute carrier organic anion transporter family member 4A1, partial [Macaca fascicularis]","gi|551891202|tpe|HG511526.1|",1420,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000080052.1 (RP11-93B14.5 gene), antisense","Q96BD0",107,1e-23,"Solute carrier organic anion transporter family member 4A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0043252|sodium-independent organic anion transport;GO:0070327|thyroid hormone transport;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;","K14354","SLCO4A; solute carrier organic anion transporter family, member 4A"]
["ENSG00000100526",929,937,972,1708.56801717568,2078,2628,3255,0.426060764784141,-1.2308688926028,1.13273992345906e-97,7.21065598801265e-96,"down","yes","CDKN3","protein_coding","chr14:54396849-54420218:+","gi|221039430|dbj|BAH11478.1|",771,2e-99,"unnamed protein product [Homo sapiens]","gi|221039429|dbj|AK293265.1|",1067,0,"Homo sapiens cDNA FLJ52251 complete cds, highly similar to Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48)","Q16667",293,5e-97,"Cyclin-dependent kinase inhibitor 3",".",".",".",".","pfam05706","CDKN3","Cyclin-dependent kinase inhibitor 3 (CDKN3). This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner.","GO:0007050|cell cycle arrest;GO:0000082|G1/S transition of mitotic cell cycle;GO:0008285|negative regulation of cell proliferation;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;","GO:0005829|cytosol;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K14167","CDKN3, KAP; cyclin-dependent kinase inhibitor 3 [EC:3.1.3.16 3.1.3.48]"]
["ENSG00000176406",44,38,57,84.061082232635,106,133,150,0.42543980302555,-1.23297308053262,7.72388847251702e-08,4.20486482805273e-07,"down","yes","RIMS2","protein_coding","chr8:103500748-104256094:+","gi|154354981|ref|NP_055492.3|",5376,0,"regulating synaptic membrane exocytosis protein 2 isoform b [Homo sapiens]","gi|426360455|ref|XM_004047410.1|",6443,0,"PREDICTED: Gorilla gorilla gorilla regulating synaptic membrane exocytosis 2, transcript variant 1 (RIMS2), mRNA","Q9UQ26",1864,0,"Regulating synaptic membrane exocytosis protein 2",".",".",".",".","pfam00168","C2","C2 domain.","GO:0017156|calcium ion-dependent exocytosis;GO:0048791|calcium ion-dependent exocytosis of neurotransmitter;GO:0019933|cAMP-mediated signaling;GO:0030073|insulin secretion;GO:0006886|intracellular protein transport;GO:1903861|positive regulation of dendrite extension;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:0010628|positive regulation of gene expression;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:0017157|regulation of exocytosis;GO:0042391|regulation of membrane potential;GO:2000300|regulation of synaptic vesicle exocytosis;GO:0061669|spontaneous neurotransmitter secretion;","GO:0030054|cell junction;GO:0070062|extracellular exosome;GO:0005622|intracellular;GO:0048786|presynaptic active zone;GO:0042734|presynaptic membrane;","GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0017137|Rab GTPase binding;","K15297","RIMS2, RIM2; regulating synaptic membrane exocytosis protein 2"]
["ENSG00000135451",721,701,657,1251.05214440845,1545,1945,2329,0.425342431475528,-1.23330331181216,2.30504538024284e-93,1.38073649981751e-91,"down","yes","TROAP","protein_coding","chr12:49323236-49331731:+","gi|578823153|ref|XP_006719244.1|",3822,0,"PREDICTED: tastin isoform X2 [Homo sapiens]","gi|578823152|ref|XM_006719181.1|",2771,0,"PREDICTED: Homo sapiens trophinin associated protein (TROAP), transcript variant X1, mRNA","Q12815",1145,0,"Tastin",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0007155|cell adhesion;","GO:0005737|cytoplasm;",".",".","."]
["ENSG00000183479",14,14,20,29.051912129175,38,40,57,0.425327477063777,-1.23335403573094,0.0011112075122776,0.00360339113934268,"down","yes","TREX2","protein_coding","chrX:153444720-153470587:-","gi|119593280|gb|EAW72874.1|",2032,0,"hCG2005011, isoform CRA_f [Homo sapiens]","gi|12751322|gb|AF319573.1|AF319573",2259,0,"Homo sapiens clone T2P4 3'-5' exonuclease TREX2 (TREX2) mRNA, complete cds","Q99871",622,0,"HAUS augmin-like complex subunit 7",".",".",".",".","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0051301|cell division;GO:0007098|centrosome cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0070652|HAUS complex;GO:0005874|microtubule;GO:0005819|spindle;","GO:0031996|thioesterase binding;","K16590","HAUS7, UIP1; HAUS augmin-like complex subunit 7"]
["ENSG00000080839",490,473,478,868.484480022507,1084,1365,1582,0.42511972854267,-1.23405888316918,1.38751781710357e-64,5.1664949143424e-63,"down","yes","RBL1","protein_coding","chr20:36996349-37095995:-","gi|34577079|ref|NP_002886.2|",5616,0,"retinoblastoma-like protein 1 isoform a [Homo sapiens]","gi|519666806|ref|NM_002895.3|",5684,0,"Homo sapiens retinoblastoma-like 1 (RBL1), transcript variant 1, mRNA","P28749",2167,0,"Retinoblastoma-like protein 1",".",".",".",".","pfam01858","RB_A","Retinoblastoma-associated protein A domain. This domain has the cyclin fold as predicted.","GO:0007049|cell cycle;GO:0006325|chromatin organization;GO:2000773|negative regulation of cellular senescence;GO:0010629|negative regulation of gene expression;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051726|regulation of cell cycle;GO:0043550|regulation of lipid kinase activity;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:1990841|promoter-specific chromatin binding;GO:0008134|transcription factor binding;","K04681","RBL1; retinoblastoma-like protein 1"]
["ENSG00000171522",54,80,72,124.773526324103,156,159,272,0.423772280941704,-1.23863887115981,1.50567868566987e-09,9.59099421704107e-09,"down","yes","PTGER4","protein_coding","chr5:40679498-40693735:+","gi|685545295|ref|XP_009206594.1|",2243,0,"PREDICTED: prostaglandin E2 receptor EP4 subtype isoform X1 [Papio anubis]","gi|38505196|ref|NM_000958.2|",3416,0,"Homo sapiens prostaglandin E receptor 4 (PTGER4), mRNA","P35408",853,0,"Prostaglandin E2 receptor EP4 subtype",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007188|adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0060348|bone development;GO:0071260|cellular response to mechanical stimulus;GO:0071380|cellular response to prostaglandin E stimulus;GO:0070371|ERK1 and ERK2 cascade;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0007254|JNK cascade;GO:0050710|negative regulation of cytokine secretion;GO:2000420|negative regulation of eosinophil extravasation;GO:0050728|negative regulation of inflammatory response;GO:0033624|negative regulation of integrin activation;GO:0050715|positive regulation of cytokine secretion;GO:0050729|positive regulation of inflammatory response;GO:0030278|regulation of ossification;GO:0051492|regulation of stress fiber assembly;GO:0032496|response to lipopolysaccharide;GO:0009612|response to mechanical stimulus;GO:0042093|T-helper cell differentiation;","GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0004957|prostaglandin E receptor activity;","K04261","PTGER4; prostaglandin E receptor 4"]
["ENSG00000088325",4083,3885,3661,7013.61052113112,8580,10896,13234,0.423736727104819,-1.2387599161132,0,0,"down","yes","TPX2","protein_coding","chr20:31739271-31801805:+","gi|15077024|gb|AAK83033.1|AF287265_1",3313,0,"hepatocellular carcinoma-associated antigen 90 [Homo sapiens]","gi|15077023|gb|AF287265.1|",3451,0,"Homo sapiens hepatocellular carcinoma-associated antigen 90 (HCA90) mRNA, complete cds","Q9ULW0",1203,0,"Targeting protein for Xklp2",".",".",".",".","pfam12214","TPX2_importin","Cell cycle regulated microtubule associated protein. This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with pfam06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain.","GO:0032147|activation of protein kinase activity;GO:0006915|apoptotic process;GO:0051301|cell division;GO:0008283|cell proliferation;GO:0000278|mitotic cell cycle;GO:0090307|mitotic spindle assembly;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0060236|regulation of mitotic spindle organization;GO:1901796|regulation of signal transduction by p53 class mediator;","GO:0043203|axon hillock;GO:0005829|cytosol;GO:0045171|intercellular bridge;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0005815|microtubule organizing center;GO:0072686|mitotic spindle;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005819|spindle;GO:0000922|spindle pole;","GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0061676|importin-alpha family protein binding;GO:0019901|protein kinase binding;","K16812","TPX2; targeting protein for Xklp2"]
["ENSG00000225269",94,70,80,147.188990262234,186,229,269,0.423347626968607,-1.24008529267978,2.00150706033455e-13,1.69394770424453e-12,"down","yes","LINC00705","lincRNA","chr10:4655427-4662419:+","gi|119606874|gb|EAW86468.1|",726,6e-90,"hCG2038755, partial [Homo sapiens]","gi|551868680|tpe|HG502614.1|",1745,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000046511.1 (RP11-117P22.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam10446","DUF2457","Protein of unknown function (DUF2457). This is a family of uncharacterized proteins.",".",".",".",".","."]
["ENSG00000168306",320,332,285,564.525056099015,613,878,1180,0.423225221035766,-1.24050249111446,5.42069818526724e-35,1.10057291155194e-33,"down","yes","ACOX2","protein_coding","chr3:58505136-58537319:-","gi|767924377|ref|XP_011532449.1|",3772,0,"PREDICTED: peroxisomal acyl-coenzyme A oxidase 2 isoform X2 [Homo sapiens]","gi|694902339|ref|XM_516559.4|",2381,0,"PREDICTED: Pan troglodytes acyl-CoA oxidase 2, branched chain (ACOX2), transcript variant X1, mRNA","Q99424",1390,0,"Peroxisomal acyl-coenzyme A oxidase 2","YGL205w",221,2e-60,"COG1960","pfam01756","ACOX","Acyl-CoA oxidase. This is a family of Acyl-CoA oxidases EC:1.3.3.6. Acyl-coA oxidase converts acyl-CoA into trans-2- enoyl-CoA.","GO:0006699|bile acid biosynthetic process;GO:0033539|fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0033540|fatty acid beta-oxidation using acyl-CoA oxidase;GO:0010942|positive regulation of cell death;GO:1902884|positive regulation of response to oxidative stress;GO:0006625|protein targeting to peroxisome;","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0005782|peroxisomal matrix;GO:0005777|peroxisome;","GO:0033791|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity;GO:0003995|acyl-CoA dehydrogenase activity;GO:0003997|acyl-CoA oxidase activity;GO:0071949|FAD binding;GO:0050660|flavin adenine dinucleotide binding;GO:0016402|pristanoyl-CoA oxidase activity;GO:0042803|protein homodimerization activity;GO:0005102|receptor binding;","K10214","ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]"]
["ENSG00000122966",1011,975,946,1771.65104176183,2181,2726,3359,0.422902162958618,-1.24160415575098,2.87443164928382e-126,2.64009703101839e-124,"down","yes","CIT","protein_coding","chr12:119685790-119877291:-","gi|332801082|ref|NP_001193928.1|",10247,0,"citron Rho-interacting kinase isoform 1 [Homo sapiens]","gi|332801081|ref|NM_001206999.1|",8708,0,"Homo sapiens citron rho-interacting serine/threonine kinase (CIT), transcript variant 1, mRNA","O14578",3842,0,"Citron Rho-interacting kinase",".",".",".",".","pfam00780","CNH","CNH domain. Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0048699|generation of neurons;GO:0007030|Golgi organization;GO:0035556|intracellular signal transduction;GO:0000278|mitotic cell cycle;GO:0000281|mitotic cytokinesis;GO:0051402|neuron apoptotic process;GO:0032467|positive regulation of cytokinesis;GO:0008064|regulation of actin polymerization or depolymerization;","GO:0032154|cleavage furrow;GO:0005829|cytosol;GO:0031985|Golgi cisterna;GO:0016020|membrane;GO:0030496|midbody;GO:0043025|neuronal cell body;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0030165|PDZ domain binding;GO:0004674|protein serine/threonine kinase activity;GO:0017048|Rho GTPase binding;GO:0097110|scaffold protein binding;GO:0017124|SH3 domain binding;","K16308","CIT; citron Rho-interacting kinase [EC:2.7.11.1]"]
["ENSG00000104833",71,76,77,135.856258982328,177,205,248,0.422531051811992,-1.2428707259209,1.27504172690997e-12,1.02513567439098e-11,"down","yes","TUBB4A","protein_coding","chr19:6494319-6502848:-","gi|537154773|gb|ERE72810.1|",2209,0,"DENN domain-containing protein 1C-like protein [Cricetulus griseus]","gi|574584814|ref|NM_006087.3|",2552,0,"Homo sapiens tubulin beta 4A class IVa (TUBB4A), transcript variant 3, mRNA","Q9D6F9",853,0,"Tubulin beta-4A chain","ECU03g0820i",728,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0030030|cell projection organization;GO:0007017|microtubule-based process;GO:0031115|negative regulation of microtubule polymerization;","GO:0005930|axoneme;GO:0042995|cell projection;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0033269|internode region of axon;GO:0005874|microtubule;GO:0043209|myelin sheath;GO:0043025|neuronal cell body;","GO:0005509|calcium ion binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07375","TUBB; tubulin beta"]
["ENSG00000171314",6485,6473,6010,11474.5795470079,14557,17061,21865,0.422421419040054,-1.24324510593099,0,0,"down","yes","PGAM1","protein_coding","chr10:97426160-97433441:+","gi|685563706|ref|XP_003904124.2|",1476,0,"PREDICTED: phosphoglycerate mutase 1 [Papio anubis]","gi|952009247|ref|NM_002629.3|",1830,0,"Homo sapiens phosphoglycerate mutase 1 (PGAM1), transcript variant 1, mRNA","P18669",501,4e-174,"Phosphoglycerate mutase 1","gpmA",293,1e-93,"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0061621|canonical glycolysis;GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0043312|neutrophil degranulation;GO:0006110|regulation of glycolytic process;GO:0043456|regulation of pentose-phosphate shunt;GO:0045730|respiratory burst;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0016020|membrane;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0034774|secretory granule lumen;","GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0004082|bisphosphoglycerate mutase activity;GO:0016787|hydrolase activity;GO:0004619|phosphoglycerate mutase activity;GO:0019901|protein kinase binding;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["ENSG00000112312",374,429,354,701.413043522921,896,1111,1246,0.421844534463406,-1.24521668525139,1.84242447155516e-46,4.94939877539777e-45,"down","yes","GMNN","protein_coding","chr6:24774931-24786099:+","gi|193785605|dbj|BAG51040.1|",1013,4e-134,"unnamed protein product [Homo sapiens]","gi|354681981|ref|NM_015895.4|",1262,0,"Homo sapiens geminin, DNA replication inhibitor (GMNN), transcript variant 1, mRNA","O75496",394,2e-135,"Geminin",".",".",".",".","pfam07412","Geminin","Geminin. This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.","GO:0009887|organ morphogenesis;GO:0071163|DNA replication preinitiation complex assembly;GO:0000082|G1/S transition of mitotic cell cycle;GO:0045786|negative regulation of cell cycle;GO:0008156|negative regulation of DNA replication;GO:2000104|negative regulation of DNA-dependent DNA replication;GO:0045892|negative regulation of transcription, DNA-templated;GO:0035563|positive regulation of chromatin binding;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042826|histone deacetylase binding;GO:0070491|repressing transcription factor binding;GO:0003714|transcription corepressor activity;","K10749","GMNN; geminin"]
["ENSG00000025770",427,345,338,670.912145979962,801,1052,1292,0.420905015359407,-1.24843339444803,2.91971125259576e-50,8.49402573756666e-49,"down","yes","NCAPH2","protein_coding","chr22:50508216-50523472:+","gi|119593964|gb|EAW73558.1|",2934,0,"kleisin beta, isoform CRA_g [Homo sapiens]","gi|12654904|gb|BC001298.1|",2074,0,"Homo sapiens non-SMC condensin II complex, subunit H2, mRNA (cDNA clone IMAGE:3459027), with apparent retained intron","Q6IBW4",1071,0,"Condensin-2 complex subunit H2",".",".",".",".","pfam06278","DUF1032","Protein of unknown function (DUF1032). This family consists of several conserved eukaryotic proteins of unknown function.","GO:0030261|chromosome condensation;","GO:0030054|cell junction;GO:0005694|chromosome;GO:0045171|intercellular bridge;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K11490","NCAPH2; condensin-2 complex subunit H2"]
["ENSG00000146918",1331,1196,1229,2279.3574891879,2860,3524,4245,0.42037184487074297,-1.25026204933988,5.46235559275141e-151,6.38532816199934e-149,"down","yes","NCAPG2","protein_coding","chr7:158631311-158704829:-","gi|530339581|ref|NP_001268862.1|",6077,0,"condensin-2 complex subunit G2 isoform b [Homo sapiens]","gi|530339580|ref|NM_001281933.1|",5253,0,"Homo sapiens non-SMC condensin II complex subunit G2 (NCAPG2), transcript variant 3, mRNA","Q86XI2",2284,0,"Condensin-2 complex subunit G2",".",".",".",".","pfam12422","Condensin2nSMC","Condensin II non structural maintenance of chromosomes subunit. This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0030261|chromosome condensation;GO:0001833|inner cell mass cell proliferation;","GO:0000796|condensin complex;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;","GO:0035064|methylated histone binding;","K11492","NCAPG2, LUZP5; condensin-2 complex subunit G2"]
["ENSG00000144354",886,811,750,1483.73667401218,1865,2297,2757,0.420286382125908,-1.250555383003,4.05199002671736e-110,3.04104216479862e-108,"down","yes","CDCA7","protein_coding","chr2:173354820-173368997:+","gi|22761027|dbj|BAC11425.1|",1002,7e-125,"unnamed protein product [Homo sapiens]","gi|21739683|emb|AL834186.1|",3141,0,"Homo sapiens mRNA; cDNA DKFZp667L165 (from clone DKFZp667L165)","Q9BWT1",279,9e-83,"Cell division cycle-associated protein 7",".",".",".",".","pfam10497","zf-4CXXC_R1","Zinc-finger domain of monoamine-oxidase A repressor R1. R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.","GO:0006915|apoptotic process;GO:0042127|regulation of cell proliferation;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".",".","."]
["ENSG00000188229",9268,9131,8446,16297.0851196462,20325,24467,31446,0.420074937596519,-1.2512813801979,0,0,"down","yes","TUBB4B","protein_coding","chr9:137241213-137243707:+","gi|529422952|ref|XP_005231325.1|",1716,0,"PREDICTED: LOW QUALITY PROTEIN: tubulin beta-4B chain [Falco peregrinus]","gi|34367683|emb|BX648521.1|",2032,0,"Homo sapiens mRNA; cDNA DKFZp686F0685 (from clone DKFZp686F0685)","P30883",660,0,"Tubulin beta-4 chain","ECU03g0820i",570,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07375","TUBB; tubulin beta"]
["ENSG00000268942",17,44,25,52.6420395118652,74,74,95,0.420054632993563,-1.2513511155126,7.44814535271577e-05,0.000288879604993327,"down","yes","CKS1BP3","processed_pseudogene","chr5:62512246-62512482:-","gi|625242789|ref|XP_007612621.1|",356,2e-41,"PREDICTED: LOW QUALITY PROTEIN: cyclin-dependent kinases regulatory subunit 1-like [Cricetulus griseus]","gi|310688903|ref|NG_001579.5|",237,1e-119,"Homo sapiens CDC28 protein kinase regulatory subunit 1B pseudogene 3 (CKS1BP3) on chromosome 5","P61025",139,2e-42,"Cyclin-dependent kinases regulatory subunit 1",".",".",".",".","pfam01111","CKS","Cyclin-dependent kinase regulatory subunit.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0044772|mitotic cell cycle phase transition;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0007346|regulation of mitotic cell cycle;GO:0006355|regulation of transcription, DNA-templated;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0019005|SCF ubiquitin ligase complex;","GO:0061575|cyclin-dependent protein serine/threonine kinase activator activity;GO:0042393|histone binding;GO:0019901|protein kinase binding;GO:0043130|ubiquitin binding;","K02219","CKS1; cyclin-dependent kinase regulatory subunit CKS1"]
["ENSG00000266983",9,8,6,13.8698620874575,15,21,30,0.419549052088563,-1.25308859991276,0.0199122259457462,0.0489818918558287,"down","yes","AC011444.1","antisense","chr19:5978403-6020363:+","gi|119589525|gb|EAW69119.1|",362,6e-41,"hCG2045263 [Homo sapiens]","gi|378548191|ref|NR_046376.1|",639,0,"Homo sapiens uncharacterized LOC100128568 (LOC100128568), long non-coding RNA",".",".",".",".",".",".",".",".","pfam01242","PTPS","6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.",".",".",".",".","."]
["ENSG00000138182",986,786,773,1543.32491056968,2009,2299,2881,0.419466423438335,-1.25337276140389,2.20894114671284e-88,1.24215909148097e-86,"down","yes","KIF20B","protein_coding","chr10:89701610-89774939:+","gi|546231677|ref|NP_001271188.1|",8744,0,"kinesin-like protein KIF20B isoform 1 [Homo sapiens]","gi|546231676|ref|NM_001284259.1|",6419,0,"Homo sapiens kinesin family member 20B (KIF20B), transcript variant 1, mRNA","Q96Q89",3372,0,"Kinesin-like protein KIF20B","SPAC25G10.07c",136,3e-31,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007050|cell cycle arrest;GO:0051301|cell division;GO:0007018|microtubule-based movement;GO:0001843|neural tube closure;GO:0048812|neuron projection morphogenesis;GO:0008284|positive regulation of cell proliferation;GO:0032467|positive regulation of cytokinesis;GO:0090316|positive regulation of intracellular protein transport;GO:1903438|positive regulation of mitotic cytokinetic process;GO:2001224|positive regulation of neuron migration;GO:0035372|protein localization to microtubule;GO:2000114|regulation of establishment of cell polarity;GO:0007088|regulation of mitotic nuclear division;","GO:0005813|centrosome;GO:0070938|contractile ring;GO:0005737|cytoplasm;GO:0030426|growth cone;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030496|midbody;GO:1990023|mitotic spindle midzone;GO:0097431|mitotic spindle pole;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0051233|spindle midzone;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0042803|protein homodimerization activity;GO:0050699|WW domain binding;","K10402","KIF20; kinesin family member 20"]
["ENSG00000188486",1400,1348,1261,2438.10419832428,3165,3582,4624,0.419094208126022,-1.25465351129906,4.58087852323066e-145,4.96381937955466e-143,"down","yes","H2AFX","protein_coding","chr11:119093854-119095467:-","gi|4504253|ref|NP_002096.1|",618,2e-74,"histone H2AX [Homo sapiens]","gi|193082971|ref|NG_008093.1|",1614,0,"Homo sapiens hydroxymethylbilane synthase (HMBS), RefSeqGene on chromosome 11","P16104",242,8e-76,"Histone H2AX","YDR225w",181,5e-53,"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006974|cellular response to DNA damage stimulus;GO:0071480|cellular response to gamma radiation;GO:0090398|cellular senescence;GO:0021987|cerebral cortex development;GO:0006342|chromatin silencing;GO:0000077|DNA damage checkpoint;GO:0006302|double-strand break repair;GO:0000724|double-strand break repair via homologous recombination;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0051321|meiotic cell cycle;GO:0006334|nucleosome assembly;GO:0045739|positive regulation of DNA repair;GO:0010212|response to ionizing radiation;GO:0007283|spermatogenesis;GO:0016032|viral process;","GO:0005813|centrosome;GO:0000794|condensed nuclear chromosome;GO:0070062|extracellular exosome;GO:0001673|male germ cell nucleus;GO:0000790|nuclear chromatin;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;GO:0005657|replication fork;GO:0035861|site of double-strand break;GO:0001741|XY body;","GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0019899|enzyme binding;GO:0042393|histone binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["ENSG00000176619",5250,5209,4769,9262.67154870385,11794,13826,17648,0.418960020929995,-1.25511551291471,1.2577980685448e-306,4.49266836038744e-304,"down","yes","LMNB2","protein_coding","chr19:2427638-2456996:-","gi|388240801|ref|NP_116126.3|",2484,0,"lamin-B2 [Homo sapiens]","gi|388240800|ref|NM_032737.3|",4643,0,"Homo sapiens lamin B2 (LMNB2), mRNA","Q03252",961,0,"Lamin-B2",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005638|lamin filament;GO:0005637|nuclear inner membrane;GO:0031965|nuclear membrane;","GO:0005198|structural molecule activity;","K07611","LMNB; lamin B"]
["ENSG00000214391",13,12,11,21.736375361286,21,31,53,0.41874477351359,-1.25585691105187,0.00430825751822745,0.0124193201332493,"down","yes","TUBAP2","processed_pseudogene","chr11:90282560-90284172:+","gi|119587277|gb|EAW66873.1|",1936,0,"hCG19802, isoform CRA_b [Homo sapiens]","gi|339275897|ref|NG_029287.1|",1613,0,"Homo sapiens tubulin alpha pseudogene 2 (TUBAP2) on chromosome 11","Q6P9V9",696,0,"Tubulin alpha-1B chain","SPBC800.05c",540,0,"COG5023","pfam00091","Tubulin","Tubulin/FtsZ family, GTPase domain. This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.","GO:0071353|cellular response to interleukin-4;GO:0000226|microtubule cytoskeleton organization;","GO:0005881|cytoplasmic microtubule;GO:0045121|membrane raft;GO:0043209|myelin sheath;","GO:0003725|double-stranded RNA binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0031625|ubiquitin protein ligase binding;","K07374","TUBA; tubulin alpha"]
["ENSG00000172167",262,242,246,456.752720342349,549,736,854,0.418067165473253,-1.25819335470804,2.94966990448692e-38,6.5696574038965e-37,"down","yes","MTBP","protein_coding","chr8:120445400-120542133:+","gi|817302775|ref|XP_012321847.1|",296,1e-51,"PREDICTED: mdm2-binding protein [Aotus nancymaae]","gi|21733248|emb|AL832671.1|",3365,0,"Homo sapiens mRNA; cDNA DKFZp313P1512 (from clone DKFZp313P1512)","Q8BJS8",108,3e-41,"Mdm2-binding protein",".",".",".",".","pfam14919","MTBP_mid","MDM2-binding. MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920.","GO:0007050|cell cycle arrest;GO:0008285|negative regulation of cell proliferation;GO:0045839|negative regulation of mitotic nuclear division;GO:0034501|protein localization to kinetochore;GO:0007089|traversing start control point of mitotic cell cycle;","GO:0000785|chromatin;GO:0000776|kinetochore;",".",".","."]
["ENSG00000188610",273,247,273,483.684850589933,617,714,931,0.417874940734916,-1.25885684965479,7.48918982123245e-39,1.68949114937932e-37,"down","yes","FAM72B","protein_coding","chr1:121167646-121185539:-","gi|155029537|ref|NP_001094380.1|",785,3e-96,"protein FAM72B isoform 1 [Homo sapiens]","gi|155029536|ref|NM_001100910.1|",2374,0,"Homo sapiens family with sequence similarity 72 member B (FAM72B), transcript variant 1, mRNA","Q86X60",306,8e-98,"Protein FAM72B",".",".",".",".","pfam14976","FAM72","FAM72 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.",".","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSG00000161800",1902,1792,1753,3321.85998544678,4195,5023,6322,0.417415393199119,-1.26044429055026,5.15061153089855e-209,1.01372444089766e-206,"down","yes","RACGAP1","protein_coding","chr12:49976923-50033136:-","gi|21361397|ref|NP_037409.2|",3298,0,"rac GTPase-activating protein 1 isoform a [Homo sapiens]","gi|987437915|ref|NM_013277.4|",3226,0,"Homo sapiens Rac GTPase activating protein 1 (RACGAP1), transcript variant 1, mRNA","Q9H0H5",1274,0,"Rac GTPase-activating protein 1",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0000915|actomyosin contractile ring assembly;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035556|intracellular signal transduction;GO:0007018|microtubule-based movement;GO:0000281|mitotic cytokinesis;GO:0051256|mitotic spindle midzone assembly;GO:0007405|neuroblast proliferation;GO:0032467|positive regulation of cytokinesis;GO:0051988|regulation of attachment of spindle microtubules to kinetochore;GO:0045995|regulation of embryonic development;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:0007283|spermatogenesis;GO:0008272|sulfate transport;","GO:0001669|acrosomal vesicle;GO:0097149|centralspindlin complex;GO:0032154|cleavage furrow;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0090543|Flemming body;GO:0005874|microtubule;GO:0030496|midbody;GO:0072686|mitotic spindle;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0051233|spindle midzone;","GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;GO:0043015|gamma-tubulin binding;GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0008017|microtubule binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901|protein kinase binding;","K16733","RACGAP1, Tum; Rac GTPase-activating protein 1"]
["ENSG00000169679",1761,1566,1582,2993.2866641806,3783,4627,5572,0.417350443212652,-1.2606687918882,2.22182983655149e-189,3.66279093054745e-187,"down","yes","BUB1","protein_coding","chr2:110637698-110678114:-","gi|519666799|ref|NP_001265545.1|",5676,0,"mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2 [Homo sapiens]","gi|519666798|ref|NM_001278616.1|",3576,0,"Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase (BUB1), transcript variant 2, mRNA","O43683",2179,0,"Mitotic checkpoint serine/threonine-protein kinase BUB1",".",".",".",".","pfam08311","Mad3_BUB1_I","Mad3/BUB1 homology region 1. Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.","GO:0006915|apoptotic process;GO:0051301|cell division;GO:0008283|cell proliferation;GO:0051754|meiotic sister chromatid cohesion, centromeric;GO:0007093|mitotic cell cycle checkpoint;GO:0007094|mitotic spindle assembly checkpoint;GO:0051983|regulation of chromosome segregation;GO:0007063|regulation of sister chromatid cohesion;GO:0016032|viral process;","GO:0000777|condensed chromosome kinetochore;GO:0000942|condensed nuclear chromosome outer kinetochore;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0016020|membrane;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K02178","BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]"]
["ENSG00000172014",14,7,11,19.5463351988703,27,32,31,0.41650708519906,-1.26358705741273,0.00633737245534643,0.0176462018072357,"down","yes","ANKRD20A4","protein_coding","chr9:64369394-64413142:+","gi|149363679|ref|NP_001092275.1|",4006,0,"ankyrin repeat domain-containing protein 20A4 [Homo sapiens]","gi|443609467|ref|NM_001012419.2|",3857,0,"Homo sapiens ankyrin repeat domain 20 family member A3 (ANKRD20A3), mRNA",".",".",".",".","all2748",80.1,1e-14,"COG0666","pfam14915","CCDC144C","CCDC144C protein coiled-coil region. This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.",".",".",".",".","."]
["ENSG00000137501",118,93,99,189.422177003071,253,264,369,0.41564377766237,-1.26658048085159,9.13685598268272e-17,9.27535148389391e-16,"down","yes","SYTL2","protein_coding","chr11:85694224-85811159:-","gi|530396906|ref|XP_005274114.1|",10920,0,"PREDICTED: synaptotagmin-like protein 2 isoform X5 [Homo sapiens]","gi|530396905|ref|XM_005274057.1|",6672,0,"PREDICTED: Homo sapiens synaptotagmin-like 2 (SYTL2), transcript variant X3, mRNA","Q9HCH5",895,0,"Synaptotagmin-like protein 2",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006887|exocytosis;GO:0006886|intracellular protein transport;GO:0010923|negative regulation of phosphatase activity;GO:0070257|positive regulation of mucus secretion;GO:0072659|protein localization to plasma membrane;GO:0006904|vesicle docking involved in exocytosis;GO:0006906|vesicle fusion;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0070382|exocytic vesicle;GO:0019897|extrinsic component of plasma membrane;GO:0042470|melanosome;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0030276|clathrin binding;GO:0042043|neurexin family protein binding;GO:0019902|phosphatase binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0001786|phosphatidylserine binding;GO:0017137|Rab GTPase binding;GO:0019905|syntaxin binding;","K17598","SYTL; synaptotagmin-like protein"]
["ENSG00000216285",82,72,68,135.91194708846,180,203,251,0.414941000559097,-1.26902187710706,2.86024597988179e-13,2.3965431998245e-12,"down","yes","AC078819.1","processed_pseudogene","chr12:104030779-104031543:+","gi|4505753|ref|NP_002620.1|",1284,3e-177,"phosphoglycerate mutase 1 isoform 1 [Homo sapiens]","gi|952556281|ref|NG_006125.4|",765,0,"Homo sapiens phosphoglycerate mutase 1 (brain) pseudogene (LOC643576) on chromosome 12","P18669",499,1e-178,"Phosphoglycerate mutase 1","gpmA",291,2e-97,"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0061621|canonical glycolysis;GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0043312|neutrophil degranulation;GO:0006110|regulation of glycolytic process;GO:0043456|regulation of pentose-phosphate shunt;GO:0045730|respiratory burst;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0016020|membrane;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0034774|secretory granule lumen;","GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0004082|bisphosphoglycerate mutase activity;GO:0016787|hydrolase activity;GO:0004619|phosphoglycerate mutase activity;GO:0019901|protein kinase binding;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["ENSG00000164087",378,334,321,632.389289716964,798,956,1213,0.414430582300894,-1.27079762635643,1.78420405086318e-53,5.50619643728784e-52,"down","yes","POC1A","protein_coding","chr3:52075253-52154690:-","gi|239787760|ref|NP_001155052.1|",1890,0,"POC1 centriolar protein homolog A isoform 2 [Homo sapiens]","gi|239787759|ref|NM_001161580.1|",1999,0,"Homo sapiens POC1 centriolar protein A (POC1A), transcript variant 2, mRNA","Q8NBT0",710,0,"POC1 centriolar protein homolog A",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0003431|growth plate cartilage chondrocyte development;GO:0007052|mitotic spindle organization;GO:0010825|positive regulation of centrosome duplication;GO:0007283|spermatogenesis;","GO:0005814|centriole;GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0000922|spindle pole;",".","K16482","POC1; centriolar protein POC1"]
["ENSG00000284946",94,91,90,168.511596105531,194,284,315,0.41428448354941,-1.27130630769967,1.2720180893444e-15,1.21639488880886e-14,"down","yes","AC068831.7","protein_coding","chr15:90966190-91022566:-","gi|119829191|ref|NP_061138.3|",3156,0,"vacuolar protein sorting-associated protein 33B isoform 1 [Homo sapiens]","gi|27261677|gb|AC068831.17|",2932,0,"Homo sapiens chromosome 15, clone RP11-2O19, complete sequence","Q9H267",1220,0,"Vacuolar protein sorting-associated protein 33B","SPBC1703.15c",193,3e-50,"COG5158","pfam03999","MAP65_ASE1","Microtubule associated protein (MAP65/ASE1 family).","GO:0032963|collagen metabolic process;GO:0007032|endosome organization;GO:0032418|lysosome localization;GO:0032400|melanosome localization;GO:0061025|membrane fusion;GO:0017185|peptidyl-lysine hydroxylation;GO:0070889|platelet alpha granule organization;GO:0015031|protein transport;GO:0006904|vesicle docking involved in exocytosis;GO:0016192|vesicle-mediated transport;","GO:0030136|clathrin-coated vesicle;GO:0005737|cytoplasm;GO:0031901|early endosome membrane;GO:0005794|Golgi apparatus;GO:0005770|late endosome;GO:0031902|late endosome membrane;GO:0005765|lysosomal membrane;GO:0005764|lysosome;GO:0048471|perinuclear region of cytoplasm;GO:0031091|platelet alpha granule;GO:0055037|recycling endosome;",".",".","."]
["ENSG00000068615",30,31,26,53.4181802971907,65,99,84,0.414013704957903,-1.27224956931845,7.9842094823116e-06,3.52562803330646e-05,"down","yes","REEP1","protein_coding","chr2:86213993-86338083:-","gi|674056904|ref|XP_008834959.1|",806,7e-96,"PREDICTED: receptor expression-enhancing protein 1 [Nannospalax galili]","gi|169808395|ref|NM_022912.2|",3857,0,"Homo sapiens receptor accessory protein 1 (REEP1), transcript variant 2, mRNA","Q9H902",314,4e-97,"Receptor expression-enhancing protein 1","SPBC30D10.09c",65.5,1e-10,"COG5052","pfam03134","TB2_DP1_HVA22","TB2/DP1, HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.","GO:0071786|endoplasmic reticulum tubular network organization;GO:0051205|protein insertion into membrane;GO:0032386|regulation of intracellular transport;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0071782|endoplasmic reticulum tubular network;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0031966|mitochondrial membrane;","GO:0008017|microtubule binding;GO:0031849|olfactory receptor binding;","K17338","REEP1_2_3_4; receptor expression-enhancing protein 1/2/3/4"]
["ENSG00000176244",84,72,73,140.070045799618,160,218,286,0.413817719196772,-1.27293267383152,2.08472126406347e-13,1.7620553786703e-12,"down","yes","ACBD7","protein_coding","chr10:15077523-15088776:-","gi|221046731|pdb|3EPY|A",449,4e-51,"Chain A, Crystal Structure Of Human Acyl-Coa Binding Domain 7 Complexed With Palmitoyl-Coa","gi|109627666|ref|NM_001039844.2|",1322,0,"Homo sapiens acyl-CoA binding domain containing 7 (ACBD7), mRNA","Q8N6N7",176,3e-52,"Acyl-CoA-binding domain-containing protein 7","SPBC1539.06",92,1e-21,"COG4281","pfam00887","ACBP","Acyl CoA binding protein.",".",".","GO:0000062|fatty-acyl-CoA binding;GO:0008289|lipid binding;",".","."]
["ENSG00000144810",119,118,96,204.1111228805,240,333,389,0.413020835502148,-1.2757135323288,1.08445312013678e-18,1.2153940604996e-17,"down","yes","COL8A1","protein_coding","chr3:99638475-99799226:+","gi|3003042|gb|AAC08999.1|",832,2e-98,"collagen VIII [Sus scrofa]","gi|395733376|ref|XM_002813363.2|",5113,0,"PREDICTED: Pongo abelii collagen, type VIII, alpha 1 (COL8A1), transcript variant X4, mRNA","P27658",334,6e-96,"Collagen alpha-1(VIII) chain",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001525|angiogenesis;GO:0048593|camera-type eye morphogenesis;GO:0007155|cell adhesion;GO:0035987|endodermal cell differentiation;GO:0050673|epithelial cell proliferation;GO:0030198|extracellular matrix organization;GO:0010811|positive regulation of cell-substrate adhesion;","GO:0005591|collagen type VIII trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;",".",".","."]
["ENSG00000051341",239,179,195,376.156233184296,481,581,700,0.41282682718767,-1.27639136881362,2.39660552468558e-31,4.46625385122083e-30,"down","yes","POLQ","protein_coding","chr3:121431427-121546641:-","gi|13892061|gb|AAK39635.1|",13867,0,"DNA polymerase theta [Homo sapiens]","gi|13892060|gb|AY032677.1|",9022,0,"Homo sapiens DNA polymerase theta (POLQ) mRNA, complete cds","O75417",5068,0,"DNA polymerase theta","PAB0592",230,2e-61,"COG1204","pfam00476","DNA_pol_A","DNA polymerase family A.","GO:0006284|base-excision repair;GO:0006974|cellular response to DNA damage stimulus;GO:0006281|DNA repair;GO:0006261|DNA-dependent DNA replication;GO:0006302|double-strand break repair;GO:0097681|double-strand break repair via alternative nonhomologous end joining;GO:0000724|double-strand break repair via homologous recombination;GO:2000042|negative regulation of double-strand break repair via homologous recombination;GO:0051260|protein homooligomerization;GO:0016446|somatic hypermutation of immunoglobulin genes;","GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051575|5'-deoxyribose-5-phosphate lyase activity;GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0042802|identical protein binding;GO:0043142|single-stranded DNA-dependent ATPase activity;","K02349","POLQ; DNA polymerase theta [EC:2.7.7.7]"]
["ENSG00000221829",541,579,474,978.822494587948,1187,1513,1914,0.412750090726742,-1.27665956262949,4.68788050027666e-69,1.9035755597755e-67,"down","yes","FANCG","protein_coding","chr9:35073835-35080016:-","gi|4759336|ref|NP_004620.1|",2762,0,"Fanconi anemia group G protein [Homo sapiens]","gi|4759335|ref|NM_004629.1|",2631,0,"Homo sapiens Fanconi anemia complementation group G (FANCG), mRNA","O15287",1068,0,"Fanconi anemia group G protein",".",".",".",".","pfam13432","TPR_16","Tetratricopeptide repeat.","GO:0006281|DNA repair;GO:0036297|interstrand cross-link repair;GO:0007005|mitochondrion organization;GO:0001541|ovarian follicle development;GO:0009314|response to radiation;GO:0007286|spermatid development;","GO:0005829|cytosol;GO:0043240|Fanconi anaemia nuclear complex;GO:0005739|mitochondrion;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0003684|damaged DNA binding;","K10894","FANCG; fanconi anemia group G protein"]
["ENSG00000154839",196,183,155,327.437616405569,383,552,606,0.412743438965164,-1.27668281287458,2.91387676474992e-27,4.74686275662976e-26,"down","yes","SKA1","protein_coding","chr18:50374995-50394173:+","gi|21450832|ref|NP_659497.1|",1131,4e-144,"spindle and kinetochore-associated protein 1 [Homo sapiens]","gi|154689618|ref|NM_145060.3|",2873,0,"Homo sapiens spindle and kinetochore associated complex subunit 1 (SKA1), transcript variant 2, mRNA","Q96BD8",440,1e-145,"Spindle and kinetochore-associated protein 1",".",".",".",".","pfam07160","DUF1395","Protein of unknown function (DUF1395). This family consists of several hypothetical eukaryotic proteins of around 250 residues in length. The function of this family is unknown.","GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0000278|mitotic cell cycle;GO:0031110|regulation of microtubule polymerization or depolymerization;","GO:0000940|condensed chromosome outer kinetochore;GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;GO:0005876|spindle microtubule;","GO:0008017|microtubule binding;",".","."]
["ENSG00000077152",515,471,427,867.569289983669,1108,1286,1682,0.412600468629434,-1.27718263505662,1.13001252788422e-68,4.53132674383178e-67,"down","yes","UBE2T","protein_coding","chr1:202331657-202341980:-","gi|874507482|ref|NP_001297255.1|",856,5e-110,"ubiquitin-conjugating enzyme E2 T isoform 2 [Homo sapiens]","gi|880796894|ref|NG_042230.1|",835,0,"Homo sapiens ubiquitin conjugating enzyme E2T (UBE2T), RefSeqGene on chromosome 1","Q9NPD8",333,2e-110,"Ubiquitin-conjugating enzyme E2 T","YDR092w",124,1e-32,"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0006974|cellular response to DNA damage stimulus;GO:0006281|DNA repair;GO:0036297|interstrand cross-link repair;GO:0051865|protein autoubiquitination;GO:0070979|protein K11-linked ubiquitination;GO:0044314|protein K27-linked ubiquitination;GO:0035519|protein K29-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0085020|protein K6-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0006513|protein monoubiquitination;GO:0016567|protein ubiquitination;","GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0061631|ubiquitin conjugating enzyme activity;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K13960","UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"]
["ENSG00000126215",222,166,158,334.215482042731,391,509,686,0.412010379343997,-1.27924741272281,5.00821893435812e-26,7.7032318027033e-25,"down","yes","XRCC3","protein_coding","chr14:103697609-103715504:-","gi|4885659|ref|NP_005423.1|",1470,0,"DNA repair protein XRCC3 [Homo sapiens]","gi|34533289|dbj|AK126706.1|",3662,0,"Homo sapiens cDNA FLJ44752 fis, clone BRACE3030057, highly  similar to Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3)","O43542",570,0,"DNA repair protein XRCC3","SPAC20H4.07",118,2e-27,"COG0468","pfam08423","Rad51","Rad51. Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.","GO:0006974|cellular response to DNA damage stimulus;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0000724|double-strand break repair via homologous recombination;GO:0036297|interstrand cross-link repair;GO:0000707|meiotic DNA recombinase assembly;GO:0090267|positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0007131|reciprocal meiotic recombination;GO:0010824|regulation of centrosome duplication;GO:0071140|resolution of mitotic recombination intermediates;GO:0010212|response to ionizing radiation;GO:0010033|response to organic substance;GO:0042148|strand invasion;GO:0090656|t-circle formation;GO:0000722|telomere maintenance via recombination;GO:0090657|telomeric loop disassembly;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0033063|Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0033065|Rad51C-XRCC3 complex;GO:0005657|replication fork;","GO:0005524|ATP binding;GO:0008094|DNA-dependent ATPase activity;GO:0003690|double-stranded DNA binding;GO:0000150|recombinase activity;GO:0003697|single-stranded DNA binding;","K10880","XRCC3; DNA-repair protein XRCC3"]
["ENSG00000123416",2457,2387,2412,4469.69480737704,5511,6675,8904,0.411924370987851,-1.27954861091669,2.73390866280482e-182,4.18505002287138e-180,"down","yes","TUBA1B","protein_coding","chr12:49127782-49131397:-","gi|525028015|ref|XP_005061428.1|",2273,0,"PREDICTED: tubulin alpha-1A chain-like [Ficedula albicollis]","gi|21753830|dbj|AK094717.1|",3170,0,"Homo sapiens cDNA FLJ37398 fis, clone BRAMY2027467, highly similar to Tubulin alpha-ubiquitous chain","Q6P9V9",876,0,"Tubulin alpha-1B chain","SPBC800.05c",711,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0071353|cellular response to interleukin-4;GO:0000226|microtubule cytoskeleton organization;","GO:0005881|cytoplasmic microtubule;GO:0045121|membrane raft;GO:0043209|myelin sheath;","GO:0003725|double-stranded RNA binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0031625|ubiquitin protein ligase binding;","K07374","TUBA; tubulin alpha"]
["ENSG00000117632",2498,2377,2366,4459.05543435113,5399,6920,8717,0.411678911779156,-1.28040854627882,1.53924723005975e-224,3.33584276105534e-222,"down","yes","STMN1","protein_coding","chr1:25884181-25906991:-","gi|62088144|dbj|BAD92519.1|",659,3e-77,"stathmin 1 variant [Homo sapiens]","gi|34367042|emb|BX647885.1|",2941,0,"Homo sapiens mRNA; cDNA DKFZp686C18102 (from clone DKFZp686C18102)","Q6DUB7",166,1e-45,"Stathmin",".",".",".",".","pfam00836","Stathmin","Stathmin family. The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.","GO:0007409|axonogenesis;GO:0061436|establishment of skin barrier;GO:0048012|hepatocyte growth factor receptor signaling pathway;GO:0007019|microtubule depolymerization;GO:0000281|mitotic cytokinesis;GO:0007052|mitotic spindle organization;GO:0031115|negative regulation of microtubule polymerization;GO:0035024|negative regulation of Rho protein signal transduction;GO:0051497|negative regulation of stress fiber assembly;GO:0070495|negative regulation of thrombin receptor signaling pathway;GO:0031175|neuron projection development;GO:0051272|positive regulation of cellular component movement;GO:0051493|regulation of cytoskeleton organization;GO:0009615|response to virus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0005874|microtubule;GO:0043005|neuron projection;","GO:0015631|tubulin binding;","K04381","STMN1; stathmin"]
["ENSG00000168268",606,697,551,1142.11986529099,1435,1709,2233,0.411525590039662,-1.28094594984087,1.60567926105267e-67,6.32047787493549e-66,"down","yes","NT5DC2","protein_coding","chr3:52524385-52535054:-","gi|12597653|ref|NP_075059.1|",2656,0,"5'-nucleotidase domain-containing protein 2 isoform 2 [Homo sapiens]","gi|197116384|ref|NM_022908.2|",2047,0,"Homo sapiens 5'-nucleotidase domain containing 2 (NT5DC2), transcript variant 2, mRNA","Q9H857",1025,0,"5'-nucleotidase domain-containing protein 2",".",".",".",".","pfam05761","5_nucleotid","5' nucleotidase family. This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.",".",".","GO:0008253|5'-nucleotidase activity;GO:0046872|metal ion binding;",".","."]
["ENSG00000122035",68,61,54,112.520749405307,136,181,213,0.411205794609519,-1.28206750011356,1.69168364452997e-11,1.26420744423456e-10,"down","yes","RASL11A","protein_coding","chr13:27270327-27273690:+","gi|795254431|ref|XP_011855355.1|",1413,0,"PREDICTED: ras-like protein family member 11A [Mandrillus leucophaeus]","gi|45592962|ref|NM_206827.1|",1543,0,"Homo sapiens RAS like family 11 member A (RASL11A), mRNA","Q6T310",463,1e-160,"Ras-like protein family member 11A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0045943|positive regulation of transcription from RNA polymerase I promoter;GO:0007165|signal transduction;GO:0006351|transcription, DNA-templated;","GO:0016020|membrane;GO:0005730|nucleolus;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07852","RASL11A; Ras-like protein family member 11A"]
["ENSG00000128052",15,21,15,31.3887909446067,38,35,78,0.410757466379304,-1.28364129546248,0.000772873155369538,0.00257865030630819,"down","yes","KDR","protein_coding","chr4:55078259-55125595:-","gi|62089388|dbj|BAD93138.1|",7362,0,"kinase insert domain receptor (a type III receptor tyrosine kinase) variant [Homo sapiens]","gi|195546779|ref|NM_002253.2|",6055,0,"Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), mRNA","P35968",2720,0,"Vascular endothelial growth factor receptor 2",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0035162|embryonic hemopoiesis;GO:0003158|endothelium development;GO:0070371|ERK1 and ERK2 cascade;GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:0010629|negative regulation of gene expression;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0045766|positive regulation of angiogenesis;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0030335|positive regulation of cell migration;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0051894|positive regulation of focal adhesion assembly;GO:0016239|positive regulation of macroautophagy;GO:0043410|positive regulation of MAPK cascade;GO:0051901|positive regulation of mitochondrial depolarization;GO:0090141|positive regulation of mitochondrial fission;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0050927|positive regulation of positive chemotaxis;GO:0001934|positive regulation of protein phosphorylation;GO:2001214|positive regulation of vasculogenesis;GO:0046777|protein autophosphorylation;GO:0043491|protein kinase B signaling;GO:0008360|regulation of cell shape;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0001570|vasculogenesis;GO:0016032|viral process;","GO:0030054|cell junction;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0097443|sorting endosome;","GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0051879|Hsp90 protein binding;GO:0042802|identical protein binding;GO:0005178|integrin binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0038085|vascular endothelial growth factor binding;GO:0005021|vascular endothelial growth factor-activated receptor activity;","K05098","KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]"]
["ENSG00000128951",899,755,729,1469.33435111456,1879,2235,2792,0.409959114072523,-1.28644806043981,1.16842761466427e-105,8.22504811373885e-104,"down","yes","DUT","protein_coding","chr15:48331011-48343373:+","gi|966951589|ref|XP_001113050.2|",1342,1e-177,"PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [Macaca mulatta]","gi|70906440|ref|NM_001025248.1|",2146,0,"Homo sapiens deoxyuridine triphosphatase (DUT), transcript variant 1, mRNA","P33316",509,1e-175,"Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial","SPAC644.05c",163,4e-46,"COG0756","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.","GO:0006260|DNA replication;GO:0006226|dUMP biosynthetic process;GO:0046081|dUTP catabolic process;GO:0006139|nucleobase-containing compound metabolic process;GO:0015949|nucleobase-containing small molecule interconversion;","GO:0070062|extracellular exosome;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0004170|dUTP diphosphatase activity;GO:0000287|magnesium ion binding;GO:0003723|RNA binding;","K01520","dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]"]
["ENSG00000130829",69,79,80,141.202582425853,178,206,282,0.409800260737083,-1.28700719261732,1.9247655826656e-13,1.63329866073269e-12,"down","yes","DUSP9","protein_coding","chrX:153642492-153651326:+","gi|768039803|ref|XP_011529425.1|",1412,0,"PREDICTED: dual specificity protein phosphatase 9 isoform X2 [Homo sapiens]","gi|972781549|ref|NM_001318503.1|",2426,0,"Homo sapiens dual specificity phosphatase 9 (DUSP9), transcript variant 1, mRNA","Q99956",524,3e-178,"Dual specificity protein phosphatase 9","SPBC17A3.06",90.9,7e-19,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000187|activation of MAPK activity;GO:0000188|inactivation of MAPK activity;GO:0007254|JNK cascade;GO:0000165|MAPK cascade;GO:0006470|protein dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K18498","DUSP9, MKP4; dual specificity phosphatase 9 [EC:3.1.3.16 3.1.3.48]"]
["ENSG00000082482",15,15,13,26.6482698868487,36,47,40,0.409781430464764,-1.28707348580271,0.00114562447122594,0.00370503098608414,"down","yes","KCNK2","protein_coding","chr1:215005775-215237093:+","gi|126365795|ref|NP_001017425.2|",2190,0,"potassium channel subfamily K member 2 isoform c [Homo sapiens]","gi|126365794|ref|NM_001017425.2|",3379,0,"Homo sapiens potassium two pore domain channel subfamily K member 2 (KCNK2), transcript variant 3, mRNA","O95069",847,0,"Potassium channel subfamily K member 2","MA2218",49.3,7e-06,"COG1226","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0003231|cardiac ventricle development;GO:0071456|cellular response to hypoxia;GO:0090102|cochlea development;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007613|memory;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:2000279|negative regulation of DNA biosynthetic process;GO:0010942|positive regulation of cell death;GO:1900039|positive regulation of cellular response to hypoxia;GO:0071805|potassium ion transmembrane transport;GO:0048678|response to axon injury;GO:0009612|response to mechanical stimulus;GO:0030322|stabilization of membrane potential;","GO:0016324|apical plasma membrane;GO:0097449|astrocyte projection;GO:0044305|calyx of Held;GO:0009986|cell surface;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015271|outward rectifier potassium channel activity;GO:0019870|potassium channel inhibitor activity;GO:0022841|potassium ion leak channel activity;","K04913","KCNK2; potassium channel subfamily K member 2"]
["ENSG00000162073",151,171,159,297.998419230362,388,451,558,0.409634953117358,-1.28758927276814,4.06312424339377e-26,6.27961060950153e-25,"down","yes","PAQR4","protein_coding","chr16:2969245-2973489:+","gi|31542756|ref|NP_689554.2|",1356,9e-178,"progestin and adipoQ receptor family member 4 isoform 1 [Homo sapiens]","gi|548961479|ref|NM_152341.4|",2793,0,"Homo sapiens progestin and adipoQ receptor family member IV (PAQR4), transcript variant 1, mRNA","Q8N4S7",526,3e-179,"Progestin and adipoQ receptor family member 4","SPBC12C2.09c",69.3,1e-11,"COG1272","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000100749",500,428,429,839.651494779926,1067,1302,1580,0.408436265504539,-1.29181712450733,3.0348963265123e-70,1.2642997914853e-68,"down","yes","VRK1","protein_coding","chr14:96797304-96931722:+","gi|563320562|pdb|2RSV|A",2031,0,"Chain A, Solution Structure Of Human Full-length Vaccinia Related Kinase 1 (vrk1)","gi|694957709|ref|XM_510157.5|",1706,0,"PREDICTED: Pan troglodytes vaccinia related kinase 1 (VRK1), transcript variant X3, mRNA","Q99986",783,0,"Serine/threonine-protein kinase VRK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0051301|cell division;GO:0090166|Golgi disassembly;GO:0043987|histone H3-S10 phosphorylation;GO:0072355|histone H3-T3 phosphorylation;GO:0007077|mitotic nuclear envelope disassembly;GO:0007084|mitotic nuclear envelope reassembly;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0008360|regulation of cell shape;","GO:0005829|cytosol;GO:0005795|Golgi stack;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0035175|histone kinase activity (H3-S10 specific);GO:0072354|histone kinase activity (H3-T3 specific);GO:0031493|nucleosomal histone binding;GO:0004672|protein kinase activity;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;","K08816","VRK; vaccinia related kinase [EC:2.7.11.1]"]
["ENSG00000196550",93,129,94,196.461315750392,247,325,349,0.407599387403992,-1.29477621166108,2.85695645102214e-16,2.8287975373365e-15,"down","yes","FAM72A","protein_coding","chr1:206186179-206204414:-","gi|178057345|ref|NP_001116640.1|",783,5e-96,"protein FAM72A isoform 1 [Homo sapiens]","gi|961513287|ref|NM_001123168.2|",2398,0,"Homo sapiens family with sequence similarity 72 member A (FAM72A), transcript variant 1, mRNA","Q5TYM5",306,2e-97,"Protein FAM72A",".",".",".",".","pfam14976","FAM72","FAM72 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.",".","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;",".",".","."]
["ENSG00000126787",2125,2036,1878,3746.21161363145,4929,5807,6811,0.407529581121313,-1.29502331164643,1.92714037257038e-194,3.34871022577815e-192,"down","yes","DLGAP5","protein_coding","chr14:55148112-55191678:-","gi|226371667|ref|NP_055565.3|",4247,0,"disks large-associated protein 5 isoform a [Homo sapiens]","gi|226371666|ref|NM_014750.4|",2973,0,"Homo sapiens discs large homolog associated protein 5 (DLGAP5), transcript variant 1, mRNA","Q15398",1641,0,"Disks large-associated protein 5",".",".",".",".","pfam03359","GKAP","Guanylate-kinase-associated protein (GKAP) protein.","GO:0008283|cell proliferation;GO:0007079|mitotic chromosome movement towards spindle pole;GO:0045842|positive regulation of mitotic metaphase/anaphase transition;GO:0007221|positive regulation of transcription of Notch receptor target;","GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0005739|mitochondrion;GO:0005634|nucleus;GO:0031616|spindle pole centrosome;","GO:0004721|phosphoprotein phosphatase activity;","K16804","DLGAP5, DLG7; disks large-associated protein 5"]
["ENSG00000153395",1894,1776,1784,3386.47907668014,4255,5197,6524,0.407016503519305,-1.29684080147018,2.31689890950886e-217,4.65503605902155e-215,"down","yes","LPCAT1","protein_coding","chr5:1456480-1523977:-","gi|33946291|ref|NP_079106.3|",2634,0,"lysophosphatidylcholine acyltransferase 1 [Homo sapiens]","gi|21748575|dbj|AK090444.1|",5042,0,"Homo sapiens mRNA for FLJ00365 protein","Q8NF37",1017,0,"Lysophosphatidylcholine acyltransferase 1",".",".",".",".","pfam01553","Acyltransferase","Acyltransferase. This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.","GO:2001246|negative regulation of phosphatidylcholine biosynthetic process;GO:0043312|neutrophil degranulation;GO:0006654|phosphatidic acid biosynthetic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0006656|phosphatidylcholine biosynthetic process;GO:0036148|phosphatidylglycerol acyl-chain remodeling;GO:0008654|phospholipid biosynthetic process;GO:0045732|positive regulation of protein catabolic process;GO:0060041|retina development in camera-type eye;GO:0043129|surfactant homeostasis;","GO:0035577|azurophil granule membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0005811|lipid particle;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0003841|1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184|1-acylglycerophosphocholine O-acyltransferase activity;GO:0047159|1-alkenylglycerophosphocholine O-acyltransferase activity;GO:0047192|1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0047191|1-alkylglycerophosphocholine O-acyltransferase activity;GO:0047144|2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005509|calcium ion binding;","K13510","LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]"]
["ENSG00000137807",1385,1257,1226,2401.32398045454,3155,3581,4551,0.40692669255579,-1.29715917708369,9.82775737673691e-155,1.20737442218154e-152,"down","yes","KIF23","protein_coding","chr15:69414246-69448427:+","gi|20143967|ref|NP_612565.1|",5038,0,"kinesin-like protein KIF23 isoform 1 [Homo sapiens]","gi|526252791|ref|NM_138555.3|",3723,0,"Homo sapiens kinesin family member 23 (KIF23), transcript variant 1, mRNA","Q02241",1945,0,"Kinesin-like protein KIF23",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.","GO:0000915|actomyosin contractile ring assembly;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007018|microtubule-based movement;GO:0000281|mitotic cytokinesis;GO:0000022|mitotic spindle elongation;GO:0051256|mitotic spindle midzone assembly;GO:0072383|plus-end-directed vesicle transport along microtubule;GO:0032467|positive regulation of cytokinesis;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:0097149|centralspindlin complex;GO:0005813|centrosome;GO:0005829|cytosol;GO:0090543|Flemming body;GO:0005925|focal adhesion;GO:0045171|intercellular bridge;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030496|midbody;GO:0072686|mitotic spindle;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K17387","KIF23; kinesin family member 23"]
["ENSG00000137094",143,162,167,294.325561205485,353,461,581,0.40571787283574,-1.30145123680082,4.34086778775106e-25,6.42075597317044e-24,"down","yes","DNAJB5","protein_coding","chr9:34989641-34998900:+","gi|281346558|gb|EFB22142.1|",1904,0,"hypothetical protein PANDA_021017, partial [Ailuropoda melanoleuca]","gi|21211678|emb|AL355377.25|",3224,0,"Human DNA sequence from clone RP11-392A14 on chromosome 9, complete sequence","O75953",652,0,"DnaJ homolog subfamily B member 5",".",".",".",".","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0006457|protein folding;GO:0006986|response to unfolded protein;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0051087|chaperone binding;GO:0051082|unfolded protein binding;","K09511","DNAJB5; DnaJ homolog subfamily B member 5"]
["ENSG00000166851",941,904,838,1668.55814183338,2116,2518,3247,0.405706540754704,-1.30149153319033,1.69204295902769e-127,1.56904445162144e-125,"down","yes","PLK1","protein_coding","chr16:23677656-23690367:+","gi|62087938|dbj|BAD92416.1|",2612,0,"polo-like kinase variant [Homo sapiens]","gi|62087937|dbj|AB209179.1|",4135,0,"Homo sapiens mRNA for polo-like kinase variant protein","P53350",901,0,"Serine/threonine-protein kinase PLK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0008283|cell proliferation;GO:0007098|centrosome cycle;GO:0045184|establishment of protein localization;GO:0016321|female meiosis chromosome segregation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0045143|homologous chromosome segregation;GO:0001578|microtubule bundle formation;GO:0000278|mitotic cell cycle;GO:0000281|mitotic cytokinesis;GO:0007077|mitotic nuclear envelope disassembly;GO:0000070|mitotic sister chromatid segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:0043066|negative regulation of apoptotic process;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0051081|nuclear envelope disassembly;GO:0018105|peptidyl-serine phosphorylation;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1900182|positive regulation of protein localization to nucleus;GO:0045862|positive regulation of proteolysis;GO:1904668|positive regulation of ubiquitin protein ligase activity;GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0031648|protein destabilization;GO:0071168|protein localization to chromatin;GO:0090435|protein localization to nuclear envelope;GO:0006468|protein phosphorylation;GO:0016567|protein ubiquitination;GO:0051726|regulation of cell cycle;GO:1902749|regulation of cell cycle G2/M phase transition;GO:0032465|regulation of cytokinesis;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0007346|regulation of mitotic cell cycle;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:1901673|regulation of mitotic spindle assembly;GO:0043393|regulation of protein binding;GO:0072425|signal transduction involved in G2 DNA damage checkpoint;GO:0007062|sister chromatid cohesion;GO:0070194|synaptonemal complex disassembly;","GO:0005813|centrosome;GO:0000785|chromatin;GO:0000942|condensed nuclear chromosome outer kinetochore;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005819|spindle;GO:0051233|spindle midzone;GO:0000922|spindle pole;GO:0000795|synaptonemal complex;","GO:0010997|anaphase-promoting complex binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0016301|kinase activity;GO:0000287|magnesium ion binding;GO:0008017|microtubule binding;GO:0004672|protein kinase activity;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;","K06631","PLK1; polo-like kinase 1 [EC:2.7.11.21]"]
["ENSG00000138092",252,281,252,488.996844121531,589,728,1010,0.405061103155002,-1.30378854103961,3.75488903811121e-38,8.32463215713667e-37,"down","yes","CENPO","protein_coding","chr2:24793136-24822376:+","gi|13236565|ref|NP_077298.1|",1601,0,"centromere protein O isoform 1 [Homo sapiens]","gi|315221124|ref|NM_024322.2|",4030,0,"Homo sapiens centromere protein O (CENPO), transcript variant 1, mRNA","Q9BU64",621,0,"Centromere protein O",".",".",".",".","pfam09496","CENP-O","Cenp-O kinetochore centromere component. This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere. It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.","GO:0034080|CENP-A containing nucleosome assembly;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005654|nucleoplasm;",".","K11507","CENPO; centromere protein O"]
["ENSG00000179029",105,64,92,162.275468866454,197,256,316,0.404893486038854,-1.3043856618879,2.70199889543897e-14,2.40499098732011e-13,"down","yes","TMEM107","protein_coding","chr17:8173237-8176399:-","gi|193786096|dbj|BAG51379.1|",544,2e-62,"unnamed protein product [Homo sapiens]","gi|14042769|dbj|AK027813.1|",2343,0,"Homo sapiens cDNA FLJ14907 fis, clone PLACE1005934","Q6UX40",173,9e-49,"Transmembrane protein 107",".",".",".",".","pfam14995","TMEM107","Transmembrane protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 138 and 164 amino acids in length. There are two completely conserved residues (H and E) that may be functionally important and four transmembrane helices. The domains in this family vary in length from 124 to 126 amino acids. The precise function of the protein family is still unknown.","GO:0060271|cilium morphogenesis;GO:0042733|embryonic digit morphogenesis;GO:0021532|neural tube patterning;GO:1904491|protein localization to ciliary transition zone;","GO:0035869|ciliary transition zone;GO:0016021|integral component of membrane;GO:0036038|TCTN-B9D complex;",".",".","."]
["ENSG00000266235",14,6,10,18.6091891559529,26,23,39,0.404801060928373,-1.30471502374324,0.00660326267347022,0.0182888757102087,"down","yes","MIR3176","miRNA","chr16:543277-543366:+",".",".",".",".","gi|301171568|ref|NR_036137.1|",90,2e-38,"Homo sapiens microRNA 3176 (MIR3176), microRNA",".",".",".",".",".",".",".",".","pfam11227","DUF3025","Protein of unknown function (DUF3025). Some members in this bacterial family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.",".",".",".",".","."]
["ENSG00000109255",118,104,106,204.356791937943,243,337,388,0.404275532342094,-1.30658920376081,8.65730693961172e-20,1.0263192148201e-18,"down","yes","NMU","protein_coding","chr4:55595229-55636698:-","gi|5729947|ref|NP_006672.1|",679,2e-86,"neuromedin-U isoform 1 preproprotein [Homo sapiens]","gi|635574606|ref|NM_006681.3|",816,0,"Homo sapiens neuromedin U (NMU), transcript variant 1, mRNA","P48645",266,7e-88,"Neuromedin-U",".",".",".",".","pfam02070","NMU","Neuromedin U.","GO:0042755|eating behavior;GO:0097009|energy homeostasis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0001696|gastric acid secretion;GO:1903999|negative regulation of eating behavior;GO:0060455|negative regulation of gastric acid secretion;GO:0007218|neuropeptide signaling pathway;GO:0009648|photoperiodism;GO:0044497|positive regulation of blood pressure in other organism;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010460|positive regulation of heart rate;GO:0031652|positive regulation of heat generation;GO:1902722|positive regulation of prolactin secretion;GO:1904058|positive regulation of sensory perception of pain;GO:0050806|positive regulation of synaptic transmission;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:2000821|regulation of grooming behavior;GO:0019233|sensory perception of pain;GO:0001659|temperature homeostasis;","GO:0005576|extracellular region;GO:0043195|terminal bouton;","GO:0005102|receptor binding;GO:0031839|type 1 neuromedin U receptor binding;GO:0031840|type 2 neuromedin U receptor binding;","K05249","NMU; neuromedin U"]
["ENSG00000161980",177,171,162,317.295956468671,347,475,706,0.404102586876741,-1.30720650787403,6.62267400712766e-24,9.32395155105681e-23,"down","yes","POLR3K","protein_coding","chr16:46407-53628:-","gi|597709807|ref|NP_057394.3|",590,2e-71,"DNA-directed RNA polymerase III subunit RPC10 [Homo sapiens]","gi|12001959|gb|AF060223.1|AF060223",1361,0,"Homo sapiens clone 009g11 My010 protein mRNA, complete cds","Q9Y2Y1",231,1e-72,"DNA-directed RNA polymerase III subunit RPC10","YDR045c",105,2e-26,"COG1594","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0051607|defense response to virus;GO:0045087|innate immune response;GO:0006386|termination of RNA polymerase III transcription;GO:0006383|transcription from RNA polymerase III promoter;GO:0042779|tRNA 3'-trailer cleavage;","GO:0005829|cytosol;GO:0005666|DNA-directed RNA polymerase III complex;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0003899|DNA-directed RNA polymerase activity;GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;","K03019","RPC11, POLR3K; DNA-directed RNA polymerase III subunit RPC11"]
["ENSG00000138587",14,16,16,28.6149523620893,29,37,74,0.403763995054374,-1.3084158282805,0.000937844705030465,0.00308846656490142,"down","yes","MNS1","protein_coding","chr15:56421544-56465137:-","gi|23271208|gb|AAH34991.1|",1754,0,"Meiosis-specific nuclear structural 1 [Homo sapiens]","gi|209915559|ref|NM_018365.2|",2020,0,"Homo sapiens meiosis specific nuclear structural 1 (MNS1), mRNA","Q8NEH6",679,0,"Meiosis-specific nuclear structural protein 1",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0044782|cilium organization;GO:0070986|left/right axis specification;GO:0051321|meiotic cell cycle;GO:0045724|positive regulation of cilium assembly;GO:0007283|spermatogenesis;","GO:0005930|axoneme;GO:0005882|intermediate filament;GO:0031514|motile cilium;GO:0005635|nuclear envelope;GO:0036126|sperm flagellum;","GO:0042802|identical protein binding;",".","."]
["ENSG00000101187",242,242,211,433.974947192583,563,653,832,0.403580636979788,-1.30907113650691,2.54270180991987e-39,5.85945430223829e-38,"down","yes","SLCO4A1","protein_coding","chr20:62642445-62685785:+","gi|119595754|gb|EAW75348.1|",3019,0,"solute carrier organic anion transporter family, member 4A1, isoform CRA_a [Homo sapiens]","gi|6537135|gb|AF104334.1|AF104334",3068,0,"Homo sapiens putative organic anion transporter mRNA, complete cds","Q96BD0",1093,0,"Solute carrier organic anion transporter family member 4A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0043252|sodium-independent organic anion transport;GO:0070327|thyroid hormone transport;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;","K14354","SLCO4A; solute carrier organic anion transporter family, member 4A"]
["ENSG00000167889",84,90,83,160.843174251394,222,216,320,0.40342201565783,-1.3096382776353,6.28438405179952e-15,5.84159998029442e-14,"down","yes","MGAT5B","protein_coding","chr17:76868456-76950393:+","gi|312596905|ref|NP_001186101.1|",4174,0,"alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 3 [Homo sapiens]","gi|74835226|dbj|AB235153.1|",4473,0,"Homo sapiens KIAA2008 mRNA for hypothetical protein","Q3V5L5",1612,0,"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B",".",".",".",".","pfam15024","Glyco_transf_18","Glycosyltransferase family 18. Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.","GO:0006487|protein N-linked glycosylation;","GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0030144|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;GO:0046872|metal ion binding;","K09661","MGAT5B; mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [EC:2.4.1.-]"]
["ENSG00000096092",266,176,216,409.94881361517,517,611,816,0.403340836757407,-1.30992861424936,2.62967043029534e-30,4.69639659810523e-29,"down","yes","TMEM14A","protein_coding","chr6:52671109-52686588:+","gi|119624784|gb|EAX04379.1|",454,1e-52,"transmembrane protein 14A, isoform CRA_a [Homo sapiens]","gi|109948293|ref|NM_014051.3|",992,0,"Homo sapiens transmembrane protein 14A (TMEM14A), mRNA","Q9Y6G1",168,4e-50,"Transmembrane protein 14A",".",".",".",".","pfam03647","Tmemb_14","Transmembrane proteins 14C. This family of short membrane proteins are as yet uncharacterized.","GO:0006915|apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:1901029|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;",".",".","."]
["ENSG00000162063",306,271,273,530.164861638756,626,848,1047,0.403339616955136,-1.30993297732195,7.33956967517454e-46,1.94993966797199e-44,"down","yes","CCNF","protein_coding","chr16:2429394-2458854:+","gi|576781|gb|AAB60342.1|",3706,0,"cyclin F [Homo sapiens]","gi|118572587|ref|NM_001761.2|",4283,0,"Homo sapiens cyclin F (CCNF), mRNA","P41002",1429,0,"Cyclin-F",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0051301|cell division;GO:0010826|negative regulation of centrosome duplication;GO:0001890|placenta development;GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0000320|re-entry into mitotic cell cycle;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0030054|cell junction;GO:0005814|centriole;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005634|nucleus;GO:0019005|SCF ubiquitin ligase complex;","GO:0004842|ubiquitin-protein transferase activity;","K10289","CCNF, FBXO1; F-box protein 1 (cyclin F)"]
["ENSG00000141499",460,453,406,823.333572819853,1028,1244,1632,0.4033307841809,-1.30996457138954,5.22065882070414e-69,2.11546359944835e-67,"down","yes","WRAP53","protein_coding","chr17:7686071-7703502:+","gi|221136854|ref|NP_060551.2|",2548,0,"telomerase Cajal body protein 1 [Homo sapiens]","gi|16552136|dbj|AK056669.1|",3617,0,"Homo sapiens cDNA FLJ32107 fis, clone OCBBF2001416, highly similar to WD repeat protein 79","Q9BUR4",986,0,"Telomerase Cajal body protein 1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0051973|positive regulation of telomerase activity;GO:0032203|telomere formation via telomerase;GO:0007004|telomere maintenance via telomerase;","GO:0015030|Cajal body;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005697|telomerase holoenzyme complex;","GO:0051087|chaperone binding;GO:0042802|identical protein binding;GO:0044877|macromolecular complex binding;GO:0003723|RNA binding;GO:0070034|telomeric RNA binding;",".","."]
["ENSG00000278635",22,12,20,33.8707598675188,52,47,58,0.402817950025376,-1.3118001219806,0.00027874918006042,0.000998980710703343,"down","yes","AC141557.2","unprocessed_pseudogene","chr12:9415641-9416718:+","gi|675674354|ref|XP_008954565.1|",248,3e-23,"PREDICTED: LOW QUALITY PROTEIN: WAS protein family homolog 1 [Pan paniscus]","gi|528319760|gb|AC254631.1|",137,9e-64,"Homo sapiens BAC clone CH17-138H12 from chromosome 12, complete sequence","Q9NQA3",88.2,2e-19,"WAS protein family homolog 6",".",".",".",".","pfam11945","WASH_WAHD","WAHD domain of WASH complex. This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see pfam04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.","GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0016197|endosomal transport;GO:0042147|retrograde transport, endosome to Golgi;","GO:0005829|cytosol;GO:0005769|early endosome;GO:0031901|early endosome membrane;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;GO:0071203|WASH complex;","GO:0003779|actin binding;GO:0043014|alpha-tubulin binding;",".","."]
["ENSG00000163918",458,426,467,846.293012684609,1086,1304,1604,0.402754488902292,-1.31202742630068,1.36754861981279e-67,5.3941263351634e-66,"down","yes","RFC4","protein_coding","chr3:186789880-186807058:-","gi|4506491|ref|NP_002907.1|",1910,0,"replication factor C subunit 4 [Homo sapiens]","gi|196114934|ref|NM_181573.2|",1448,0,"Homo sapiens replication factor C subunit 4 (RFC4), transcript variant 2, mRNA","P35249",740,0,"Replication factor C subunit 4","SPAC23D3.02",351,2e-116,"COG0470","pfam08542","Rep_fac_C","Replication factor C C-terminal domain. This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.","GO:0042769|DNA damage response, detection of DNA damage;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0006271|DNA strand elongation involved in DNA replication;GO:0070987|error-free translesion synthesis;GO:0042276|error-prone translesion synthesis;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0031390|Ctf18 RFC-like complex;GO:0005663|DNA replication factor C complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0019899|enzyme binding;","K10755","RFC2_4; replication factor C subunit 2/4"]
["ENSG00000123485",1618,1504,1484,2880.13626670696,3520,4582,5550,0.402636802826347,-1.31244904774382,6.02937158045296e-195,1.05722290039797e-192,"down","yes","HJURP","protein_coding","chr2:233833416-233854566:-","gi|83816964|ref|NP_060880.3|",3544,0,"Holliday junction recognition protein isoform a [Homo sapiens]","gi|545479117|ref|NM_018410.4|",3187,0,"Homo sapiens Holliday junction recognition protein (HJURP), transcript variant 1, mRNA","Q8NCD3",1369,0,"Holliday junction recognition protein",".",".",".",".","pfam12346","HJURP_mid","Holliday junction recognition protein-associated repeat. Vertebral Holliday junction recognition proteins carry an SCM3 domain at their N-terminus as do the eukaryotic fungi, but they also carry this central, conserved region. The function of this family is not known. Further downstream there is also a repeated domain, also of unknown function. Investigation of Scm3 and associated proteins is likely to be directly relevant to understanding the mechanism of HJURP-mediated CENP-A chromatin assembly at human centromeres.","GO:0007049|cell cycle;GO:0034080|CENP-A containing nucleosome assembly;GO:0007059|chromosome segregation;GO:0051101|regulation of DNA binding;GO:0043254|regulation of protein complex assembly;","GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0042393|histone binding;GO:0042802|identical protein binding;",".","."]
["ENSG00000149503",1287,1218,1116,2267.83232568744,2874,3481,4384,0.401540193566328,-1.31638368832407,1.86595166538475e-171,2.64635850896626e-169,"down","yes","INCENP","protein_coding","chr11:62123973-62153163:+","gi|426368784|ref|XP_004051382.1|",2321,0,"PREDICTED: inner centromere protein [Gorilla gorilla gorilla]","gi|102467234|ref|NM_001040694.1|",3964,0,"Homo sapiens inner centromere protein (INCENP), transcript variant 1, mRNA","Q9NQS7",893,0,"Inner centromere protein",".",".",".",".","pfam03941","INCENP_ARK-bind","Inner centromere protein, ARK binding region. This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.","GO:0007059|chromosome segregation;GO:0000281|mitotic cytokinesis;","GO:0000801|central element;GO:0010369|chromocenter;GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0000800|lateral element;GO:0005874|microtubule;GO:0030496|midbody;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005721|pericentric heterochromatin;GO:0032991|macromolecular complex;GO:0005819|spindle;",".","K11515","INCENP; inner centromere protein"]
["ENSG00000135643",21,20,18,37.0504261983456,55,46,73,0.401196067867792,-1.3176206287564,9.94228020503412e-05,0.000379435497813016,"down","yes","KCNMB4","protein_coding","chr12:70366276-70434292:+","gi|26051275|ref|NP_055320.4|",1052,7e-129,"calcium-activated potassium channel subunit beta-4 [Homo sapiens]","gi|341926278|ref|NM_014505.5|",4725,0,"Homo sapiens potassium calcium-activated channel subfamily M regulatory beta subunit 4 (KCNMB4), mRNA","Q86W47",409,2e-130,"Calcium-activated potassium channel subunit beta-4",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0007268|synaptic transmission;GO:0005513|detection of calcium ion;GO:0019228|neuronal action potential;GO:0006813|potassium ion transport;GO:0046928|regulation of neurotransmitter secretion;GO:0019229|regulation of vasoconstriction;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04941","KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4"]
["ENSG00000163535",808,673,697,1366.13689217993,1784,2138,2517,0.400919787059592,-1.31861447263867,5.12773237605892e-100,3.37555297165271e-98,"down","yes","SGO2","protein_coding","chr2:200510008-200583782:+","gi|767917016|ref|XP_005246401.2|",6234,0,"PREDICTED: shugoshin-like 2 isoform X3 [Homo sapiens]","gi|229892305|ref|NM_152524.5|",4214,0,"Homo sapiens shugoshin-like 2 (S. pombe) (SGOL2), transcript variant 1, mRNA","Q562F6",2402,0,"Shugoshin 2",".",".",".",".","pfam07558","Shugoshin_N","Shugoshin N-terminal coiled-coil region. The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.","GO:0051301|cell division;GO:0051754|meiotic sister chromatid cohesion, centromeric;","GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0030892|mitotic cohesin complex;GO:0016604|nuclear body;GO:0005654|nucleoplasm;",".","K11581","SGOL2; shugoshin-like 2"]
["ENSG00000138193",299,201,218,448.653776147986,539,733,860,0.400774672400981,-1.31913675690334,5.57103409871422e-33,1.08320671064516e-31,"down","yes","PLCE1","protein_coding","chr10:94030812-94332823:+","gi|117168250|ref|NP_057425.3|",11593,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1 [Homo sapiens]","gi|117168249|ref|NM_016341.3|",7593,0,"Homo sapiens phospholipase C epsilon 1 (PLCE1), transcript variant 1, mRNA","Q9P212",4444,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0000187|activation of MAPK activity;GO:0019722|calcium-mediated signaling;GO:0008283|cell proliferation;GO:0007010|cytoskeleton organization;GO:0006651|diacylglycerol biosynthetic process;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0032835|glomerulus development;GO:0007507|heart development;GO:0043647|inositol phosphate metabolic process;GO:0048016|inositol phosphate-mediated signaling;GO:0016042|lipid catabolic process;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007265|Ras protein signal transduction;GO:0001558|regulation of cell growth;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;GO:0045859|regulation of protein kinase activity;GO:0046578|regulation of Ras protein signal transduction;GO:0006940|regulation of smooth muscle contraction;","GO:0005829|cytosol;GO:0000139|Golgi membrane;GO:0005886|plasma membrane;","GO:0019899|enzyme binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004629|phospholipase C activity;GO:0017016|Ras GTPase binding;","K05860","PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]"]
["ENSG00000134363",187,190,182,351.452659498492,445,578,634,0.400645994413432,-1.31960004192653,5.35808558654001e-32,1.01419778992329e-30,"down","yes","FST","protein_coding","chr5:53480409-53487134:+","gi|7242222|ref|NP_037541.1|",1587,0,"follistatin isoform FST344 precursor [Homo sapiens]","gi|767935178|ref|XM_005248403.3|",2527,0,"PREDICTED: Homo sapiens follistatin (FST), transcript variant X5, mRNA","P19883",616,0,"Follistatin",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0032926|negative regulation of activin receptor signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0051798|positive regulation of hair follicle development;","GO:0005576|extracellular region;","GO:0048185|activin binding;GO:0043395|heparan sulfate proteoglycan binding;","K04661","FST; follistatin"]
["ENSG00000183647",84,82,74,150.706514789814,183,247,285,0.400022742520803,-1.32184607091418,1.41847844109037e-15,1.35175949465174e-14,"down","yes","ZNF530","protein_coding","chr19:57599885-57612722:+","gi|7959277|dbj|BAA96032.1|",3012,0,"KIAA1508 protein [Homo sapiens]","gi|3264845|gb|AC003682.1|AC003682",4367,0,"Homo sapiens chromosome 19, overlapping cosmids F18547, F11133, R27945, R28830 and R32804, complete sequence","Q6P9A1",1120,0,"Zinc finger protein 530",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000049541",738,758,676,1365.39625446412,1715,2124,2636,0.399869656871423,-1.32239828496211,7.29315103086244e-109,5.34868049746292e-107,"down","yes","RFC2","protein_coding","chr7:74231499-74254458:-","gi|31563534|ref|NP_852136.1|",1901,0,"replication factor C subunit 2 isoform 1 [Homo sapiens]","gi|525343556|ref|NM_181471.2|",1695,0,"Homo sapiens replication factor C subunit 2 (RFC2), transcript variant 1, mRNA","P35250",736,0,"Replication factor C subunit 2","SPAC1687.03c",449,2e-153,"COG0470","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0042769|DNA damage response, detection of DNA damage;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0070987|error-free translesion synthesis;GO:0042276|error-prone translesion synthesis;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0031390|Ctf18 RFC-like complex;GO:0005663|DNA replication factor C complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0019899|enzyme binding;","K10755","RFC2_4; replication factor C subunit 2/4"]
["ENSG00000137812",790,708,691,1376.90934367559,1861,2096,2521,0.399758912352566,-1.32279789692029,5.40096717406117e-98,3.44946539249311e-96,"down","yes","KNL1","protein_coding","chr15:40594020-40664342:+","gi|444299649|ref|NP_733468.3|",12059,0,"protein CASC5 isoform 1 [Homo sapiens]","gi|444299648|ref|NM_170589.4|",7685,0,"Homo sapiens cancer susceptibility candidate 5 (CASC5), transcript variant 1, mRNA","Q8NG31",4645,0,"Kinetochore scaffold 1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0001675|acrosome assembly;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0051301|cell division;GO:0034080|CENP-A containing nucleosome assembly;GO:0010923|negative regulation of phosphatase activity;GO:0034501|protein localization to kinetochore;","GO:0001669|acrosomal vesicle;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K11542","CASC5, KNL1; protein CASC5"]
["ENSG00000161981",222,256,212,434.225313102812,555,628,882,0.39950437613873,-1.32371678848238,4.20470018287378e-35,8.57296586969022e-34,"down","yes","SNRNP25","protein_coding","chr16:53010-57669:+","gi|119606283|gb|EAW85877.1|",1004,8e-129,"chromosome 16 open reading frame 33, isoform CRA_a [Homo sapiens]","gi|426380496|ref|XM_004056851.1|",1774,0,"PREDICTED: Gorilla gorilla gorilla U11/U12 small nuclear ribonucleoprotein 25 kDa protein-like (LOC101143820), mRNA","Q9BV90",271,5e-86,"U11/U12 small nuclear ribonucleoprotein 25 kDa protein",".",".",".",".","pfam02150","RNA_POL_M_15KD","RNA polymerases M/15 Kd subunit.","GO:0000398|mRNA splicing, via spliceosome;GO:0008380|RNA splicing;","GO:0005829|cytosol;GO:0045171|intercellular bridge;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005689|U12-type spliceosomal complex;",".","K13153","SNRNP25; U11/U12 small nuclear ribonucleoprotein 25 kDa protein"]
["ENSG00000196557",10,7,12,18.183178600357,17,28,44,0.399313283032203,-1.32440703131622,0.00656041453662756,0.018185868867846,"down","yes","CACNA1H","protein_coding","chr16:1153121-1221772:+","gi|53832009|ref|NP_066921.2|",9731,0,"voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens]","gi|53832008|ref|NM_021098.2|",8088,0,"Homo sapiens calcium voltage-gated channel subunit alpha1 H (CACNA1H), transcript variant 1, mRNA","O95180",3752,0,"Voltage-dependent T-type calcium channel subunit alpha-1H",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0032342|aldosterone biosynthetic process;GO:0070509|calcium ion import;GO:0032870|cellular response to hormone stimulus;GO:0035865|cellular response to potassium ion;GO:0034651|cortisol biosynthetic process;GO:0098662|inorganic cation transmembrane transport;GO:0086010|membrane depolarization during action potential;GO:0006936|muscle contraction;GO:0007517|muscle organ development;GO:0007520|myoblast fusion;GO:0019228|neuronal action potential;GO:2000344|positive regulation of acrosome reaction;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0008016|regulation of heart contraction;GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;","GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;","GO:0008332|low voltage-gated calcium channel activity;GO:0046872|metal ion binding;GO:0097110|scaffold protein binding;GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;","K04855","CACNA1H; voltage-dependent calcium channel T type alpha-1H"]
["ENSG00000072571",178,204,198,366.355069772938,458,589,688,0.398704038405376,-1.32660987666548,4.79655583237205e-32,9.11487378273815e-31,"down","yes","HMMR","protein_coding","chr5:163460203-163491945:+","gi|397479277|ref|XP_003810951.1|",3174,0,"PREDICTED: hyaluronan mediated motility receptor isoform X1 [Pan paniscus]","gi|217272801|ref|NM_001142556.1|",3102,0,"Homo sapiens hyaluronan mediated motility receptor (HMMR), transcript variant 1, mRNA","O75330",1195,0,"Hyaluronan mediated motility receptor",".",".",".",".","pfam05483","SCP-1","Synaptonemal complex protein 1 (SCP-1). Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.","GO:0030214|hyaluronan catabolic process;GO:0010389|regulation of G2/M transition of mitotic cell cycle;","GO:0009986|cell surface;GO:0005813|centrosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0015630|microtubule cytoskeleton;GO:0005886|plasma membrane;","GO:0005540|hyaluronic acid binding;","K06267","HMMR, RHAMM; hyaluronan-mediated motility receptor"]
["ENSG00000178966",246,215,205,419.369162609679,530,678,777,0.398425725549276,-1.32761729255128,3.49970724122581e-39,8.00739659178688e-38,"down","yes","RMI1","protein_coding","chr9:83980711-84004074:+","gi|153791761|ref|NP_079221.2|",3271,0,"recQ-mediated genome instability protein 1 [Homo sapiens]","gi|153791760|ref|NM_024945.2|",3420,0,"Homo sapiens RecQ mediated genome instability 1 (RMI1), mRNA","Q9H9A7",1264,0,"RecQ-mediated genome instability protein 1",".",".",".",".","pfam08585","DUF1767","Domain of unknown function (DUF1767). Eukaryotic domain of unknown function. This domain is found to the N-terminus of the nucleic acid binding domain.","GO:0006260|DNA replication;GO:0042593|glucose homeostasis;GO:0035264|multicellular organism growth;GO:0002023|reduction of food intake in response to dietary excess;GO:0009749|response to glucose;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;","GO:0000166|nucleotide binding;","K10990","RMI1, BRAP75; RecQ-mediated genome instability protein 1"]
["ENSG00000115541",248,198,200,405.416785471778,414,675,874,0.398155447645213,-1.3285962978804,2.14053817406249e-26,3.35937349888668e-25,"down","yes","HSPE1","protein_coding","chr2:197499994-197503457:+","gi|594678955|ref|XP_007187221.1|",486,3e-57,"PREDICTED: 10 kDa heat shock protein, mitochondrial-like [Balaenoptera acutorostrata scammoni]","gi|209574325|ref|NM_002157.2|",947,0,"Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA","P26772",180,6e-55,"10 kDa heat shock protein, mitochondrial","SPCC550.06c",75.1,5e-16,"COG0234","pfam00166","Cpn10","Chaperonin 10 Kd subunit. This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis.","GO:0051085|chaperone mediated protein folding requiring cofactor;GO:0006986|response to unfolded protein;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0051087|chaperone binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;",".","."]
["ENSG00000273679",24,20,12,34.9894668714625,42,47,80,0.397794420099906,-1.32990505539407,0.000177472855945188,0.00065363690003261,"down","yes","AC100757.1","processed_pseudogene","chr15:22371736-22373570:+","gi|426350822|ref|XP_004042964.1|",1907,0,"PREDICTED: RING finger protein 145 isoform 1 [Gorilla gorilla gorilla]","gi|331028596|ref|NG_028860.1|",1835,0,"Homo sapiens RING finger protein 145-like (LOC441711) pseudogene on chromosome 15","Q96MT1",735,0,"RING finger protein 145",".",".",".",".","pfam13705","TRC8_N","TRC8 N-terminal domain. This region is found at the N-terminus of the TRC8 protein. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG.","GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209|protein polyubiquitination;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0061630|ubiquitin protein ligase activity;GO:0008270|zinc ion binding;",".","."]
["ENSG00000162745",17,21,5,26.8540854803802,33,38,58,0.397721143382773,-1.33017083512629,0.00173506613523788,0.0054327850026734,"down","yes","OLFML2B","protein_coding","chr1:161983192-162023854:-","gi|46195719|ref|NP_056256.1|",3726,0,"olfactomedin-like protein 2B isoform 2 precursor [Homo sapiens]","gi|663070959|ref|NM_015441.2|",3160,0,"Homo sapiens olfactomedin like 2B (OLFML2B), transcript variant 2, mRNA","Q68BL8",1439,0,"Olfactomedin-like protein 2B",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.",".","GO:0005576|extracellular region;",".",".","."]
["ENSG00000079616",825,775,789,1508.69700262895,1839,2353,3004,0.397188877478898,-1.33210287139345,6.90513429432097e-114,5.41407440117329e-112,"down","yes","KIF22","protein_coding","chr16:29790719-29805385:+","gi|6453818|ref|NP_015556.1|",2978,0,"kinesin-like protein KIF22 isoform 1 [Homo sapiens]","gi|372266147|ref|NM_001256270.1|",2256,0,"Homo sapiens kinesin family member 22 (KIF22), transcript variant 3, mRNA","Q14807",1151,0,"Kinesin-like protein KIF22","ECU11g2020",221,2e-61,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006281|DNA repair;GO:0051310|metaphase plate congression;GO:0007018|microtubule-based movement;GO:0000278|mitotic cell cycle;GO:0007080|mitotic metaphase plate congression;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:0007062|sister chromatid cohesion;","GO:0000785|chromatin;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0000776|kinetochore;GO:0005874|microtubule;GO:0072686|mitotic spindle;GO:0016607|nuclear speck;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003677|DNA binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10403","KIF22; kinesin family member 22"]
["ENSG00000129195",459,408,392,795.676054565548,1018,1293,1453,0.396710952016045,-1.33383986831132,4.72600720079755e-68,1.87562195244821e-66,"down","yes","PIMREG","protein_coding","chr17:6444415-6451469:+","gi|305632783|ref|NP_001182157.1|",1091,5e-142,"protein FAM64A isoform 2 [Homo sapiens]","gi|305632780|ref|NM_019013.2|",1544,0,"Homo sapiens family with sequence similarity 64 member A (FAM64A), transcript variant 1, mRNA","Q9BSJ6",424,2e-143,"Protein PIMREG",".",".",".",".","pfam07326","DUF1466","Protein of unknown function (DUF1466). This family consists of several hypothetical mammalian proteins of around 240 residues in length.","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0005730|nucleolus;GO:0005634|nucleus;",".",".","."]
["ENSG00000104147",103,85,95,179.380703627342,258,241,347,0.396041029066852,-1.33627819648888,2.03933891446115e-16,2.03490786250009e-15,"down","yes","OIP5","protein_coding","chr15:41309268-41332621:-","gi|675785209|ref|XP_003826657.2|",1213,8e-164,"PREDICTED: protein Mis18-beta isoform X1 [Pan paniscus]","gi|24307928|ref|NM_007280.1|",1236,0,"Homo sapiens Opa interacting protein 5 (OIP5), transcript variant 1, mRNA","O43482",436,1e-151,"Protein Mis18-beta",".",".",".",".","pfam03226","Yippee-Mis18","Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus.","GO:0007154|cell communication;GO:0007049|cell cycle;GO:0051301|cell division;GO:0034080|CENP-A containing nucleosome assembly;GO:0007059|chromosome segregation;","GO:0015030|Cajal body;GO:0000785|chromatin;GO:0010369|chromocenter;GO:0000775|chromosome, centromeric region;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K11565","OIP5; opa-interacting protein 5"]
["ENSG00000156970",906,832,759,1578.275272324,1910,2524,3099,0.395783885245298,-1.33721522214313,9.22953784945683e-121,8.01888856037493e-119,"down","yes","BUB1B","protein_coding","chr15:40161023-40221136:+","gi|62087144|dbj|BAD92019.1|",5536,0,"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta variant [Homo sapiens]","gi|168229167|ref|NM_001211.5|",3722,0,"Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B), mRNA","O60566",2046,0,"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta",".",".",".",".","pfam08311","Mad3_BUB1_I","Mad3/BUB1 homology region 1. Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0006915|apoptotic process;GO:0051301|cell division;GO:0008283|cell proliferation;GO:0051754|meiotic sister chromatid cohesion, centromeric;GO:0007091|metaphase/anaphase transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0007093|mitotic cell cycle checkpoint;GO:0007094|mitotic spindle assembly checkpoint;GO:0034501|protein localization to kinetochore;","GO:0005680|anaphase-promoting complex;GO:0000777|condensed chromosome kinetochore;GO:0000940|condensed chromosome outer kinetochore;GO:0000778|condensed nuclear chromosome kinetochore;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0005815|microtubule organizing center;GO:0048471|perinuclear region of cytoplasm;GO:0051233|spindle midzone;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K06637","BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]"]
["ENSG00000163507",769,672,608,1295.60189159282,1655,2035,2462,0.395629288739623,-1.33777886101659,2.72674800719955e-104,1.8918530778009e-102,"down","yes","CIP2A","protein_coding","chr3:108549869-108589644:-","gi|931568690|ref|XP_003825110.2|",4641,0,"PREDICTED: protein CIP2A [Pan paniscus]","gi|190194354|ref|NM_020890.2|",4075,0,"Homo sapiens KIAA1524 (KIAA1524), mRNA","Q8TCG1",1769,0,"Protein CIP2A",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:2000179|positive regulation of neural precursor cell proliferation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000186193",758,717,695,1374.22314674621,1723,2086,2745,0.395479908174322,-1.33832369251183,1.04565512890121e-110,7.97177712499862e-109,"down","yes","SAPCD2","protein_coding","chr9:137062124-137070588:-","gi|190886454|ref|NP_848543.2|",1418,0,"suppressor APC domain-containing protein 2 [Homo sapiens]","gi|71726463|gb|DQ150361.1|",3839,0,"Homo sapiens tumor specificity and mitosis phase-dependent expression protein mRNA, complete cds","Q86UD0",550,0,"Suppressor APC domain-containing protein 2",".",".",".",".","pfam11414","Suppressor_APC","Adenomatous polyposis coli tumor suppressor protein. The tumor suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.","GO:0000132|establishment of mitotic spindle orientation;GO:0008284|positive regulation of cell proliferation;GO:0090175|regulation of establishment of planar polarity;GO:0098725|symmetric cell division;","GO:0045179|apical cortex;GO:0043296|apical junction complex;GO:0016324|apical plasma membrane;GO:0005923|bicellular tight junction;GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005634|nucleus;",".",".","."]
["ENSG00000132646",2028,1887,1765,3597.86961729188,4619,5530,6949,0.395311150495857,-1.3389394452239,3.94408299106764e-251,1.04210236618784e-248,"down","yes","PCNA","protein_coding","chr20:5114953-5126626:-","gi|655718534|ref|XP_008254499.1|",1386,0,"PREDICTED: proliferating cell nuclear antigen isoform X1 [Oryctolagus cuniculus]","gi|33239449|ref|NM_002592.2|",1355,0,"Homo sapiens proliferating cell nuclear antigen (PCNA), transcript variant 1, mRNA","P61258",536,0,"Proliferating cell nuclear antigen","SPBC16D10.09",299,1e-97,"COG0592","pfam02747","PCNA_C","Proliferating cell nuclear antigen, C-terminal domain. N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.","GO:0034644|cellular response to UV;GO:0006260|DNA replication;GO:0030855|epithelial cell differentiation;GO:0006298|mismatch repair;GO:0032077|positive regulation of deoxyribonuclease activity;GO:0045739|positive regulation of DNA repair;GO:0045740|positive regulation of DNA replication;GO:0019985|translesion synthesis;","GO:0005813|centrosome;GO:0016604|nuclear body;GO:0043596|nuclear replication fork;GO:0043626|PCNA complex;GO:0070557|PCNA-p21 complex;","GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0032139|dinucleotide insertion or deletion binding;GO:0070182|DNA polymerase binding;GO:0030337|DNA polymerase processivity factor activity;GO:0035035|histone acetyltransferase binding;GO:0042802|identical protein binding;GO:0032405|MutLalpha complex binding;GO:0000701|purine-specific mismatch base pair DNA N-glycosylase activity;GO:0030971|receptor tyrosine kinase binding;","K04802","PCNA; proliferating cell nuclear antigen"]
["ENSG00000278903",33,34,30,61.5030750153753,74,107,111,0.395140165366831,-1.33956359347088,2.51461738587652e-07,1.29997159310604e-06,"down","yes","CU633906.2","lincRNA","chr21:6318434-6360415:+","gi|578836324|ref|XP_006723978.1|",248,6e-41,"PREDICTED: uncharacterized protein LOC102724219 isoform X2 [Homo sapiens]","gi|685844651|tpe|LN608804.1|",2257,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000479511.1 (CH507-145C22.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam10326","7TM_GPCR_Str","Serpentine type 7TM GPCR chemoreceptor Str. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".",".",".",".","."]
["ENSG00000109805",644,615,539,1138.24309906165,1396,1829,2200,0.395118888872836,-1.33964127810408,1.69655019303513e-94,1.03882730550037e-92,"down","yes","NCAPG","protein_coding","chr4:17810902-17844862:+","gi|635138256|ref|XP_008015984.1|",5152,0,"PREDICTED: condensin complex subunit 3 [Chlorocebus sabaeus]","gi|402167319|ref|NM_022346.4|",4661,0,"Homo sapiens non-SMC condensin I complex subunit G (NCAPG), transcript variant 1, mRNA","Q9BPX3",1984,0,"Condensin complex subunit 3","SPCC188.03",186,4e-47,"COG5218","pfam12719","Cnd3","Nuclear condensing complex subunits, C-term domain. The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.","GO:0051301|cell division;GO:0007076|mitotic chromosome condensation;","GO:0000779|condensed chromosome, centromeric region;GO:0000796|condensin complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0005634|nucleus;",".","K06678","YCG1, CAPG; condensin complex subunit 3"]
["ENSG00000140525",836,839,828,1588.78650913851,1951,2576,3037,0.394951512811355,-1.34025254671245,6.7391204861722e-117,5.48456354165778e-115,"down","yes","FANCI","protein_coding","chr15:89243949-89317261:+","gi|164607124|ref|NP_001106849.1|",6575,0,"Fanconi anemia group I protein isoform 1 [Homo sapiens]","gi|164607123|ref|NM_001113378.1|",4743,0,"Homo sapiens Fanconi anemia complementation group I (FANCI), transcript variant 1, mRNA","Q9NVI1",2508,0,"Fanconi anemia group I protein",".",".",".",".","pfam14678","FANCI_S4","FANCI solenoid 4. This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.","GO:0036297|interstrand cross-link repair;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0031398|positive regulation of protein ubiquitination;","GO:0005829|cytosol;GO:0016020|membrane;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0070182|DNA polymerase binding;","K10895","FANCI; fanconi anemia group I protein"]
["ENSG00000112118",2423,2223,2145,4306.9404088111,5332,6739,8481,0.39446276399992,-1.34203897393401,2.34788739814249e-274,7.07594564615194e-272,"down","yes","MCM3","protein_coding","chr6:52264009-52284881:-","gi|394582093|ref|NP_002379.3|",4191,0,"DNA replication licensing factor MCM3 isoform 1 [Homo sapiens]","gi|394582092|ref|NM_002388.4|",3208,0,"Homo sapiens minichromosome maintenance complex component 3 (MCM3), transcript variant 1, mRNA","P25205",1539,0,"DNA replication licensing factor MCM3","SPCC1682.02c",678,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;","GO:0005658|alpha DNA polymerase:primase complex;GO:0005813|centrosome;GO:0042555|MCM complex;GO:0016020|membrane;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0004386|helicase activity;","K02541","MCM3; DNA replication licensing factor MCM3 [EC:3.6.4.12]"]
["ENSG00000005961",11,14,7,20.2949964279007,27,32,37,0.394142700298743,-1.34321003946859,0.0030500080056774,0.00910095210604976,"down","yes","ITGA2B","protein_coding","chr17:44372180-44389505:-","gi|694966577|ref|XP_001150497.3|",5052,0,"PREDICTED: integrin alpha-IIb isoform X2 [Pan troglodytes]","gi|974005392|ref|NM_000419.4|",3333,0,"Homo sapiens integrin subunit alpha 2b (ITGA2B), mRNA","P08514",1919,0,"Integrin alpha-IIb",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007160|cell-matrix adhesion;GO:0030198|extracellular matrix organization;GO:0007229|integrin-mediated signaling pathway;GO:0070527|platelet aggregation;GO:0002576|platelet degranulation;GO:0002687|positive regulation of leukocyte migration;GO:0045652|regulation of megakaryocyte differentiation;","GO:0072562|blood microparticle;GO:0009986|cell surface;GO:0009897|external side of plasma membrane;GO:0070062|extracellular exosome;GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0005886|plasma membrane;GO:0031092|platelet alpha granule membrane;","GO:0050840|extracellular matrix binding;GO:0070051|fibrinogen binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K06476","ITGA2B; integrin alpha 2B"]
["ENSG00000115163",446,404,335,749.943429598667,887,1162,1555,0.393947347529549,-1.34392527366775,3.09755106866186e-55,1.00076323303769e-53,"down","yes","CENPA","protein_coding","chr2:26764289-26801067:+","gi|931565759|ref|XP_014199230.1|",458,2e-51,"PREDICTED: histone H3-like centromeric protein A [Pan paniscus]","gi|109637780|ref|NM_001809.3|",1431,0,"Homo sapiens centromere protein A (CENPA), transcript variant 1, mRNA","P49450",179,3e-52,"Histone H3-like centromeric protein A","SPBC1105.17",86.3,4e-19,"COG2036","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0034080|CENP-A containing nucleosome assembly;GO:0000132|establishment of mitotic spindle orientation;GO:0051382|kinetochore assembly;GO:0000281|mitotic cytokinesis;GO:0006334|nucleosome assembly;GO:0071459|protein localization to chromosome, centromeric region;GO:0016032|viral process;","GO:0000775|chromosome, centromeric region;GO:0000939|condensed chromosome inner kinetochore;GO:0000778|condensed nuclear chromosome kinetochore;GO:0000780|condensed nuclear chromosome, centromeric region;GO:0005829|cytosol;GO:0000788|nuclear nucleosome;GO:0031618|nuclear pericentric heterochromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11495","CENPA; histone H3-like centromeric protein A"]
["ENSG00000108691",10,16,9,22.2007648657936,26,33,48,0.393935437296332,-1.34396889141072,0.00208127516122439,0.00641753839278548,"down","yes","CCL2","protein_coding","chr17:34255218-34257203:+","gi|119600617|gb|EAW80211.1|",214,1e-18,"chemokine (C-C motif) ligand 2, isoform CRA_a [Homo sapiens]","gi|237858769|ref|NG_012123.1|",996,0,"Homo sapiens C-C motif chemokine ligand 2 (CCL2), RefSeqGene on chromosome 17","Q5RA36",86.3,1e-19,"C-C motif chemokine 2",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006955|immune response;GO:0006954|inflammatory response;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;","K14624","CCL2, MCP1; C-C motif chemokine 2"]
["ENSG00000177602",225,235,254,454.930178198171,567,737,859,0.393897279523286,-1.34410864196642,3.9085720491963e-39,8.92172043608262e-38,"down","yes","HASPIN","protein_coding","chr17:3723903-3726699:+","gi|56790919|ref|NP_114171.2|",3902,0,"serine/threonine-protein kinase haspin [Homo sapiens]","gi|56790918|ref|NM_031965.2|",2797,0,"Homo sapiens germ cell associated 2 (haspin) (GSG2), mRNA","Q8TF76",1472,0,"Serine/threonine-protein kinase haspin","SPAC23C4.03",187,4e-50,"COG5072","pfam12330","DUF3635","Domain of unknown function (DUF3635). This family may be a potential Haspin-related leucine-zipper. A leucine zipper was proposed to be present towards the C-terminus of human Haspin, (up-stream of the current family); however, as this domain would appear to span several helices and be largely within a loop structure, the actual zipper might be further downstream, and be this family, which is the very C-terminal part of the Sch. pombe sequence.","GO:2000751|histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore;GO:0035556|intracellular signal transduction;GO:0007064|mitotic sister chromatid cohesion;GO:0071459|protein localization to chromosome, centromeric region;GO:0006468|protein phosphorylation;","GO:0005813|centrosome;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0072354|histone kinase activity (H3-T3 specific);GO:0004672|protein kinase activity;","K16315","GSG2; serine/threonine-protein kinase haspin [EC:2.7.11.1]"]
["ENSG00000123374",619,530,570,1091.62738114693,1358,1684,2171,0.39385603297991,-1.34425972018518,2.79601382807768e-88,1.56771845104542e-86,"down","yes","CDK2","protein_coding","chr12:55966769-55972784:+","gi|148692652|gb|EDL24599.1|",1432,0,"cyclin-dependent kinase 2, isoform CRA_a, partial [Mus musculus]","gi|589811554|ref|NM_001798.4|",1541,0,"Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant 1, mRNA","P24941",538,0,"Cyclin-dependent kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0051301|cell division;GO:0071732|cellular response to nitric oxide;GO:0007099|centriole replication;GO:0051298|centrosome duplication;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0016572|histone phosphorylation;GO:0051321|meiotic cell cycle;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0007275|multicellular organismal development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0018105|peptidyl-serine phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0032298|positive regulation of DNA-dependent DNA replication initiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006813|potassium ion transport;GO:0006468|protein phosphorylation;GO:0007265|Ras protein signal transduction;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0060968|regulation of gene silencing;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0010033|response to organic substance;","GO:0015030|Cajal body;GO:0005813|centrosome;GO:0000781|chromosome, telomeric region;GO:0000793|condensed chromosome;GO:0097123|cyclin A1-CDK2 complex;GO:0097124|cyclin A2-CDK2 complex;GO:0097134|cyclin E1-CDK2 complex;GO:0097135|cyclin E2-CDK2 complex;GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005768|endosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0000805|X chromosome;GO:0000806|Y chromosome;","GO:0005524|ATP binding;GO:0030332|cyclin binding;GO:0097472|cyclin-dependent protein kinase activity;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0046872|metal ion binding;GO:0019904|protein domain specific binding;GO:0004674|protein serine/threonine kinase activity;","K02206","CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"]
["ENSG00000164142",48,38,41,80.7045600475725,114,106,163,0.393714092540752,-1.34477974186517,7.87307728451168e-09,4.67968920381083e-08,"down","yes","FAM160A1","protein_coding","chr4:151409216-151663632:+","gi|158341646|ref|NP_001103447.1|",5048,0,"protein FAM160A1 [Homo sapiens]","gi|158341645|ref|NM_001109977.1|",4576,0,"Homo sapiens family with sequence similarity 160 member A1 (FAM160A1), mRNA",".",".",".",".",".",".",".",".","pfam10257","RAI16-like","Retinoic acid induced 16-like protein. This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.",".",".",".",".","."]
["ENSG00000216775",149,135,158,282.096236918007,389,417,527,0.393211442810637,-1.34662278886006,1.20452489165483e-25,1.8207583158494e-24,"down","yes","AL109918.1","transcribed_unprocessed_pseudogene","chr6:52664366-52669155:+","gi|829976614|ref|XP_012606182.1|",410,2e-70,"PREDICTED: uncharacterized protein LOC105863530 isoform X1 [Microcebus murinus]","gi|212276032|ref|NR_024403.1|",3755,0,"Homo sapiens uncharacterized LOC730101 (LOC730101), transcript variant 1, long non-coding RNA","Q99729",84.7,5e-16,"Heterogeneous nuclear ribonucleoprotein A/B",".",".",".",".","pfam01673","Herpes_env","Herpesvirus putative major envelope glycoprotein. This family consists of probable major envelope glycoproteins from members of the herpesviridae including herpes simplex virus, human cytomegalovirus and varicella-zoster virus. Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication.","GO:0001837|epithelial to mesenchymal transition;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0090575|RNA polymerase II transcription factor complex;","GO:0003729|mRNA binding;GO:0003723|RNA binding;","K13044","HNRNPABD; heterogeneous nuclear ribonucleoprotein A/B/D"]
["ENSG00000214776",16,16,15,30.0131424633628,47,36,58,0.393130153496019,-1.34692107065526,0.000375885859400346,0.00131700026450751,"down","yes","AC092821.1","transcribed_unprocessed_pseudogene","chr12:9480608-9576275:+","gi|767972523|ref|XP_011519192.1|",896,3e-106,"PREDICTED: ovostatin homolog 2 isoform X2 [Homo sapiens]","gi|34367097|emb|BX647938.1|",7806,0,"Homo sapiens mRNA; cDNA DKFZp686A1124 (from clone DKFZp686A1124)","Q6IE36",365,2e-101,"Ovostatin homolog 2",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSG00000164362",73,68,65,130.963741316879,151,233,241,0.393017112450041,-1.34733596431358,1.62159385080598e-13,1.37967808532623e-12,"down","yes","TERT","protein_coding","chr5:1253147-1295069:-","gi|109633031|ref|NP_937983.2|",5324,0,"telomerase reverse transcriptase isoform 1 [Homo sapiens]","gi|109633030|ref|NM_198253.2|",4018,0,"Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 1, mRNA","O14746",2043,0,"Telomerase reverse transcriptase",".",".",".",".","pfam12009","Telomerase_RBD","Telomerase ribonucleoprotein complex - RNA binding domain. Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.","GO:0071456|cellular response to hypoxia;GO:0071897|DNA biosynthetic process;GO:0022616|DNA strand elongation;GO:0070200|establishment of protein localization to telomere;GO:0007005|mitochondrion organization;GO:2000773|negative regulation of cellular senescence;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0010629|negative regulation of gene expression;GO:0060253|negative regulation of glial cell proliferation;GO:0043524|negative regulation of neuron apoptotic process;GO:1903704|negative regulation of production of siRNA involved in RNA interference;GO:0045766|positive regulation of angiogenesis;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:0046326|positive regulation of glucose import;GO:0042635|positive regulation of hair cycle;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:1902895|positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:0032092|positive regulation of protein binding;GO:2000648|positive regulation of stem cell proliferation;GO:1903620|positive regulation of transdifferentiation;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030422|production of siRNA involved in RNA interference;GO:0031647|regulation of protein stability;GO:0090399|replicative senescence;GO:0046686|response to cadmium ion;GO:0032774|RNA biosynthetic process;GO:0006278|RNA-dependent DNA replication;GO:0000723|telomere maintenance;GO:0007004|telomere maintenance via telomerase;GO:0001172|transcription, RNA-templated;","GO:0000781|chromosome, telomeric region;GO:0005829|cytosol;GO:0042645|mitochondrial nucleoid;GO:0000784|nuclear chromosome, telomeric region;GO:0016607|nuclear speck;GO:0000783|nuclear telomere cap complex;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016605|PML body;GO:0031379|RNA-directed RNA polymerase complex;GO:0000333|telomerase catalytic core complex;GO:0005697|telomerase holoenzyme complex;GO:1990572|TERT-RMRP complex;","GO:0051087|chaperone binding;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0016779|nucleotidyltransferase activity;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;GO:0047485|protein N-terminus binding;GO:0003723|RNA binding;GO:0003968|RNA-directed RNA polymerase activity;GO:0003964|RNA-directed DNA polymerase activity;GO:0003720|telomerase activity;GO:0070034|telomeric RNA binding;GO:0003721|telomeric template RNA reverse transcriptase activity;GO:0042162|telomeric DNA binding;GO:0001223|transcription coactivator binding;GO:0000049|tRNA binding;","K11126","TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]"]
["ENSG00000076382",1205,1205,1085,2225.36111322634,2758,3613,4234,0.392660333061195,-1.34864623201517,9.62667353413267e-160,1.22157420477862e-157,"down","yes","SPAG5","protein_coding","chr17:28577565-28599279:-","gi|73623035|ref|NP_006452.3|",5426,0,"sperm-associated antigen 5 [Homo sapiens]","gi|28316814|gb|AF345347.2|",3968,0,"Homo sapiens mitotic spindle-associated protein p126 mRNA, complete cds","Q96R06",2094,0,"Sperm-associated antigen 5",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.","GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0051294|establishment of spindle orientation;GO:0000070|mitotic sister chromatid segregation;GO:0032388|positive regulation of intracellular transport;GO:0071539|protein localization to centrosome;GO:0051988|regulation of attachment of spindle microtubules to kinetochore;GO:0090235|regulation of metaphase plate congression;GO:0007051|spindle organization;","GO:0034451|centriolar satellite;GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0000776|kinetochore;GO:0035371|microtubule plus-end;GO:0030496|midbody;GO:0072686|mitotic spindle;GO:0097431|mitotic spindle pole;GO:0005876|spindle microtubule;","GO:0008017|microtubule binding;",".","."]
["ENSG00000091651",337,330,287,607.914790498934,821,915,1145,0.392483018043463,-1.34929786206654,1.64912665381333e-53,5.11388342423658e-52,"down","yes","ORC6","protein_coding","chr16:46689643-46698394:+","gi|686771905|ref|XP_002834093.2|",835,1e-103,"PREDICTED: origin recognition complex subunit 6 [Pongo abelii]","gi|10436364|dbj|AK024077.1|",1798,0,"Homo sapiens cDNA FLJ14015 fis, clone HEMBA1000327","Q9Y5N6",305,2e-97,"Origin recognition complex subunit 6",".",".",".",".","pfam05460","ORC6","Origin recognition complex subunit 6 (ORC6). This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organisms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.","GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0051782|negative regulation of cell division;","GO:0001650|fibrillar center;GO:0016020|membrane;GO:0005664|nuclear origin of replication recognition complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000808|origin recognition complex;","GO:0003688|DNA replication origin binding;","K02608","ORC6; origin recognition complex subunit 6"]
["ENSG00000196154",17,20,20,36.3555081505575,42,57,76,0.392245867415386,-1.35016984741543,6.30000295794762e-05,0.000246679774772419,"down","yes","S100A4","protein_coding","chr1:153543613-153550136:-","gi|795346443|ref|XP_011783512.1|",567,9e-70,"PREDICTED: protein S100-A4 isoform X1 [Colobus angolensis palliatus]","gi|115430249|ref|NM_019554.2|",462,0,"Homo sapiens S100 calcium binding protein A4 (S100A4), transcript variant 2, mRNA","P26447",207,2e-66,"Protein S100-A4",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0001837|epithelial to mesenchymal transition;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0005509|calcium ion binding;GO:0048306|calcium-dependent protein binding;GO:0042802|identical protein binding;GO:0050786|RAGE receptor binding;GO:0003723|RNA binding;GO:0046914|transition metal ion binding;",".","."]
["ENSG00000168393",1034,1094,895,1926.21379635458,2501,2898,3779,0.392181678789969,-1.35040595491121,7.70522293335481e-118,6.46166695384989e-116,"down","yes","DTYMK","protein_coding","chr2:241675742-241686991:-","gi|795354454|ref|XP_011784927.1|",1179,5e-159,"PREDICTED: thymidylate kinase isoform X1 [Colobus angolensis palliatus]","gi|284055294|ref|NM_012145.3|",1209,0,"Homo sapiens deoxythymidylate kinase (DTYMK), transcript variant 1, mRNA","P23919",435,1e-151,"Thymidylate kinase","SPCC70.07c",193,5e-58,"COG0125","pfam02223","Thymidylate_kin","Thymidylate kinase.","GO:0008283|cell proliferation;GO:0071363|cellular response to growth factor stimulus;GO:0006233|dTDP biosynthetic process;GO:0006235|dTTP biosynthetic process;GO:0006227|dUDP biosynthetic process;GO:0045445|myoblast differentiation;GO:0015949|nucleobase-containing small molecule interconversion;GO:0046686|response to cadmium ion;GO:0043627|response to estrogen;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005758|mitochondrial intermembrane space;GO:0005759|mitochondrial matrix;","GO:0005524|ATP binding;GO:0050145|nucleoside phosphate kinase activity;GO:0004798|thymidylate kinase activity;GO:0009041|uridylate kinase activity;","K00943","tmk, DTYMK; dTMP kinase [EC:2.7.4.9]"]
["ENSG00000101945",114,96,82,185.412656220037,219,314,354,0.392146322923131,-1.35053602226486,2.10977801947345e-18,2.32533705369165e-17,"down","yes","SUV39H1","protein_coding","chrX:48695554-48709012:+","gi|197101223|ref|NP_001125697.1|",2203,0,"histone-lysine N-methyltransferase SUV39H1 [Pongo abelii]","gi|531990829|ref|NM_001282166.1|",2978,0,"Homo sapiens suppressor of variegation 3-9 homolog 1 (SUV39H1), transcript variant 1, mRNA","Q5RB81",822,0,"Histone-lysine N-methyltransferase SUV39H1","SPBC428.08c",190,6e-51,"COG2940","pfam05033","Pre-SET","Pre-SET motif. This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains.","GO:0007049|cell cycle;GO:0030154|cell differentiation;GO:0036123|histone H3-K9 dimethylation;GO:0036124|histone H3-K9 trimethylation;GO:0042754|negative regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048511|rhythmic process;GO:0006364|rRNA processing;GO:0006351|transcription, DNA-templated;","GO:0000775|chromosome, centromeric region;GO:0000792|heterochromatin;GO:0005652|nuclear lamina;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046974|histone methyltransferase activity (H3-K9 specific);GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0008270|zinc ion binding;","K11419","SUV39H, CLR4; histone-lysine N-methyltransferase SUV39H [EC:2.1.1.43]"]
["ENSG00000145604",625,569,533,1102.99942173245,1440,1749,2050,0.390985645703401,-1.35481245219529,1.41441446387886e-95,8.77209844993424e-94,"down","yes","SKP2","protein_coding","chr5:36151989-36184319:+","gi|16306595|ref|NP_005974.2|",2227,0,"S-phase kinase-associated protein 2 isoform 1 [Homo sapiens]","gi|340805878|ref|NM_005983.3|",3481,0,"Homo sapiens S-phase kinase-associated protein 2, E3 ubiquitin protein ligase (SKP2), transcript variant 1, mRNA","Q13309",862,0,"S-phase kinase-associated protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0008283|cell proliferation;GO:0071460|cellular response to cell-matrix adhesion;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:1902916|positive regulation of protein polyubiquitination;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0043687|post-translational protein modification;GO:0016579|protein deubiquitination;GO:0000209|protein polyubiquitination;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0019005|SCF ubiquitin ligase complex;","GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;","K03875","SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)"]
["ENSG00000106034",44,21,46,71.0720255659863,93,119,124,0.390883524832025,-1.35518931646132,3.75961972698808e-07,1.91182560754406e-06,"down","yes","CPED1","protein_coding","chr7:120988677-121297444:+","gi|157671945|ref|NP_079189.4|",5356,0,"cadherin-like and PC-esterase domain-containing protein 1 isoform 1 precursor [Homo sapiens]","gi|157671944|ref|NM_024913.4|",5320,0,"Homo sapiens cadherin like and PC-esterase domain containing 1 (CPED1), transcript variant 1, mRNA","A4D0V7",2067,0,"Cadherin-like and PC-esterase domain-containing protein 1",".",".",".",".","pfam12733","Cadherin-like","Cadherin-like beta sandwich domain. This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.",".","GO:0005783|endoplasmic reticulum;",".",".","."]
["ENSG00000149929",176,179,182,343.613719198944,435,512,698,0.39056837692464,-1.35635295134853,1.81292665289001e-32,3.48284156184686e-31,"down","yes","HIRIP3","protein_coding","chr16:29992321-29996436:-","gi|402912417|ref|XP_003918763.1|",2374,0,"PREDICTED: HIRA-interacting protein 3 isoform X1 [Papio anubis]","gi|344179118|ref|NM_003609.4|",3048,0,"Homo sapiens HIRA interacting protein 3 (HIRIP3), transcript variant 1, mRNA","Q9BW71",829,0,"HIRA-interacting protein 3",".",".",".",".","pfam09649","CHZ","Histone chaperone domain CHZ. This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones.","GO:0006333|chromatin assembly or disassembly;","GO:0005730|nucleolus;GO:0005634|nucleus;",".",".","."]
["ENSG00000000460",145,118,113,239.916554257475,309,373,462,0.390525619619925,-1.35651089841203,1.92655981066922e-24,2.76690138705792e-23,"down","yes","C1orf112","protein_coding","chr1:169662007-169854080:+","gi|530365032|ref|XP_005245374.1|",4607,0,"PREDICTED: uncharacterized protein C1orf112 isoform X2 [Homo sapiens]","gi|694890251|ref|XM_009437999.1|",4210,0,"PREDICTED: Pan troglodytes chromosome 1 open reading frame, human C1orf112 (C1H1orf112), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam14868","DUF4487","Domain of unknown function (DUF4487). This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.",".",".",".",".","."]
["ENSG00000278771",77,47,41,104.424520527031,109,260,120,0.390436822199219,-1.35683897462207,0.0052248641144363,0.0148005843793872,"down","yes","RN7SL3","misc_RNA","chr14:49853616-49853914:-","gi|743741691|ref|XP_010965357.1|",420,1e-48,"PREDICTED: uncharacterized protein LOC105078493 [Camelus bactrianus]","gi|224586809|ref|NG_011406.1|",299,5e-154,"Homo sapiens RNA, 7SL, cytoplasmic 3 (RN7SL3) pseudogene on chromosome 14",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000212907",4026,3610,3580,7168.25029923314,7719,11800,15275,0.390403162994486,-1.35696335341593,1.29049593104223e-32,2.48662192986438e-31,"down","yes","MT-ND4L","protein_coding","chrMT:10470-10766:+","gi|189065211|dbj|BAG34934.1|",463,1e-57,"unnamed protein product [Homo sapiens]","gi|1001887523|gb|KU761989.1|",297,6e-153,"Homo sapiens haplogroup H63 mitochondrion, complete genome","P03901",176,2e-56,"NADH-ubiquinone oxidoreductase chain 4L",".",".",".",".","pfam00420","Oxidored_q2","NADH-ubiquinone/plastoquinone oxidoreductase chain 4L.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;","GO:0016021|integral component of membrane;GO:0005747|mitochondrial respiratory chain complex I;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03882","ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:1.6.5.3]"]
["ENSG00000112742",505,479,475,933.188239350519,1163,1484,1812,0.390298309823361,-1.35735087965017,5.20624057285571e-85,2.76633521127386e-83,"down","yes","TTK","protein_coding","chr6:80003887-80042527:+","gi|724943298|ref|XP_010386834.1|",4427,0,"PREDICTED: dual specificity protein kinase TTK isoform X1 [Rhinopithecus roxellana]","gi|685537722|ref|XM_003897838.2|",3300,0,"PREDICTED: Papio anubis TTK protein kinase (TTK), transcript variant X2, mRNA","P33981",1676,0,"Dual specificity protein kinase TTK",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0051304|chromosome separation;GO:0016321|female meiosis chromosome segregation;GO:0033316|meiotic spindle assembly checkpoint;GO:0007094|mitotic spindle assembly checkpoint;GO:0007052|mitotic spindle organization;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0046777|protein autophosphorylation;GO:0034501|protein localization to kinetochore;GO:1903096|protein localization to meiotic spindle midzone;GO:0007051|spindle organization;","GO:0005737|cytoplasm;GO:0000776|kinetochore;GO:0016020|membrane;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0042803|protein homodimerization activity;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0004713|protein tyrosine kinase activity;","K08866","TTK, MPS1; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]"]
["ENSG00000166924",12,23,19,34.6830786569098,31,71,66,0.390006475634096,-1.35843001632879,0.000298938676311545,0.00106756696698705,"down","yes","NYAP1","protein_coding","chr7:100483927-100494799:+","gi|37537554|ref|NP_775835.2|",3336,0,"neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 [Homo sapiens]","gi|427918072|ref|NM_173564.3|",3581,0,"Homo sapiens neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 (NYAP1), mRNA","Q6ZVC0",1289,0,"Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1",".",".",".",".","pfam15452","NYAP_C","Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter. NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.","GO:0048812|neuron projection morphogenesis;GO:0014065|phosphatidylinositol 3-kinase signaling;","GO:0005622|intracellular;",".",".","."]
["ENSG00000231483",8,4,11,14.7208917455674,14,25,33,0.389754531743283,-1.35936229740227,0.0129621485643082,0.0336311435981137,"down","yes","AL365356.4","lincRNA","chr10:5608475-5610793:-","gi|119606847|gb|EAW86441.1|",198,4e-17,"hCG2045466, partial [Homo sapiens]","gi|551868027|tpe|HG502624.1|",613,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000046558.1 (RP11-336A10.5 gene), lincRNA",".",".",".",".",".",".",".",".","pfam10204","DuoxA","Dual oxidase maturation factor. DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.",".",".",".",".","."]
["ENSG00000131747",6713,6046,5973,12001.3823584421,15284,19078,22894,0.389182140677265,-1.36148258761396,0,0,"down","yes","TOP2A","protein_coding","chr17:40388516-40417950:-","gi|19913406|ref|NP_001058.2|",7354,0,"DNA topoisomerase 2-alpha [Homo sapiens]","gi|300193028|ref|NM_001067.3|",5753,0,"Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A), mRNA","P11388",2837,0,"DNA topoisomerase 2-alpha","ECU04g0350_1",727,0,"COG0187","pfam00521","DNA_topoisoIV","DNA gyrase/topoisomerase IV, subunit A.","GO:0030263|apoptotic chromosome condensation;GO:0006974|cellular response to DNA damage stimulus;GO:0007059|chromosome segregation;GO:0006266|DNA ligation;GO:0006265|DNA topological change;GO:0040016|embryonic cleavage;GO:0002244|hematopoietic progenitor cell differentiation;GO:0044774|mitotic DNA integrity checkpoint;GO:0043065|positive regulation of apoptotic process;GO:0045870|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045070|positive regulation of viral genome replication;GO:0042752|regulation of circadian rhythm;GO:0000712|resolution of meiotic recombination intermediates;GO:0048511|rhythmic process;GO:0000819|sister chromatid segregation;","GO:0000793|condensed chromosome;GO:0005737|cytoplasm;GO:0009330|DNA topoisomerase complex (ATP-hydrolyzing);GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0008301|DNA binding, bending;GO:0003918|DNA topoisomerase type II (ATP-hydrolyzing) activity;GO:0008094|DNA-dependent ATPase activity;GO:0008144|drug binding;GO:0019899|enzyme binding;GO:0042826|histone deacetylase binding;GO:0000287|magnesium ion binding;GO:0008022|protein C-terminus binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0005080|protein kinase C binding;GO:0003723|RNA binding;GO:0043130|ubiquitin binding;","K03164","TOP2; DNA topoisomerase II [EC:5.99.1.3]"]
["ENSG00000127589",44,43,53,89.8140523686849,100,147,187,0.389106390028563,-1.36176342198646,8.45844787355052e-10,5.52103359001836e-09,"down","yes","TUBBP1","transcribed_processed_pseudogene","chr8:30351873-30353518:+","gi|223429|prf||0805287A",2112,0,"tubulin beta","gi|646227337|ref|NG_001206.4|",1646,0,"Homo sapiens tubulin beta pseudogene 1 (TUBBP1) on chromosome 8","P09244",813,0,"Tubulin beta-7 chain","ECU03g0820i",687,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;","K07375","TUBB; tubulin beta"]
["ENSG00000197587",9,8,12,18.6485713415305,23,26,41,0.388633630687583,-1.36351734392079,0.00393453264088936,0.0114411677336762,"down","yes","DMBX1","protein_coding","chr1:46506996-46514226:+","gi|22218349|ref|NP_671725.1|",1462,0,"diencephalon/mesencephalon homeobox protein 1 isoform b [Homo sapiens]","gi|27436934|ref|NM_147192.2|",2882,0,"Homo sapiens diencephalon/mesencephalon homeobox 1 (DMBX1), transcript variant 2, mRNA","Q8NFW5",567,0,"Diencephalon/mesencephalon homeobox protein 1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0008343|adult feeding behavior;GO:0008344|adult locomotory behavior;GO:0007420|brain development;GO:0007417|central nervous system development;GO:0048589|developmental growth;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["ENSG00000184661",409,361,366,729.494253118513,909,1152,1435,0.387660651045877,-1.36713379111626,8.23617560541247e-69,3.32341747023422e-67,"down","yes","CDCA2","protein_coding","chr8:25458997-25507920:+","gi|44681484|ref|NP_689775.2|",5021,0,"cell division cycle-associated protein 2 isoform 1 [Homo sapiens]","gi|961658077|ref|NM_152562.3|",3728,0,"Homo sapiens cell division cycle associated 2 (CDCA2), transcript variant 1, mRNA","Q69YH5",1938,0,"Cell division cycle-associated protein 2",".",".",".",".","pfam15276","PP1_bind","Protein phosphatase 1 binding. This domain contains a protein phosphatase 1 (PP1) binding site.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0035307|positive regulation of protein dephosphorylation;","GO:0005694|chromosome;GO:0005829|cytosol;GO:0005654|nucleoplasm;",".","K17590","CDCA2; cell division cycle-associated protein 2"]
["ENSG00000167325",1332,1266,1183,2428.52112280405,3000,3855,4793,0.387572294242657,-1.36746265206873,3.28700663852752e-187,5.28331533699323e-185,"down","yes","RRM1","protein_coding","chr11:4094707-4138876:+","gi|194388656|dbj|BAG60296.1|",3889,0,"unnamed protein product [Homo sapiens]","gi|34527885|dbj|AK122695.1|",3150,0,"Homo sapiens cDNA FLJ16162 fis, clone BRCAN2012402, highly  similar to RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHAIN (EC 1.17.4.1)","P23921",1495,0,"Ribonucleoside-diphosphate reductase large subunit","SPAC1F7.05",1101,0,"COG0209","pfam02867","Ribonuc_red_lgC","Ribonucleotide reductase, barrel domain.","GO:0021846|cell proliferation in forebrain;GO:0009263|deoxyribonucleotide biosynthetic process;GO:0006260|DNA replication;GO:0008584|male gonad development;GO:0000278|mitotic cell cycle;GO:0051290|protein heterotetramerization;GO:0006206|pyrimidine nucleobase metabolic process;GO:0010212|response to ionizing radiation;GO:0060041|retina development in camera-type eye;","GO:0042995|cell projection;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0005635|nuclear envelope;GO:0005971|ribonucleoside-diphosphate reductase complex;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0004748|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;","K10807","RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"]
["ENSG00000135519",6,9,17,20.8900581388902,29,30,40,0.387424783085075,-1.36801185057364,0.00355395135182329,0.0104409041423093,"down","yes","KCNH3","protein_coding","chr12:49539157-49558308:+","gi|38569493|ref|NP_036416.1|",4766,0,"potassium voltage-gated channel subfamily H member 3 isoform 1 [Homo sapiens]","gi|930425331|ref|NM_001314030.1|",3109,0,"Homo sapiens potassium voltage-gated channel subfamily H member 3 (KCNH3), transcript variant 2, mRNA","Q9ULD8",1840,0,"Potassium voltage-gated channel subfamily H member 3","CC0285_1",85.5,5e-17,"COG2202","pfam13426","PAS_9","PAS domain.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;","GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0000155|phosphorelay sensor kinase activity;GO:0005249|voltage-gated potassium channel activity;","K04906","KCNH3; potassium voltage-gated channel Eag-related subfamily H member 3"]
["ENSG00000100626",37,47,38,78.6835955804453,99,132,144,0.387026512975152,-1.36949569433785,3.945243016321e-09,2.40957793107704e-08,"down","yes","GALNT16","protein_coding","chr14:69259277-69357033:+","gi|50510795|dbj|BAD32383.1|",2783,0,"mKIAA1130 protein [Mus musculus]","gi|15777901|emb|AL157996.8|",3703,0,"Human chromosome 14 DNA sequence BAC C-2525P14 of library CalTech-D from chromosome 14 of Homo sapiens (Human), complete sequence","Q8N428",1067,0,"Polypeptide N-acetylgalactosaminyltransferase 16",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0018242|protein O-linked glycosylation via serine;GO:0018243|protein O-linked glycosylation via threonine;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSG00000078900",52,47,52,97.6055691994727,145,135,181,0.386586055389142,-1.37113849609601,1.38222934873811e-10,9.65957959364518e-10,"down","yes","TP73","protein_coding","chr1:3652520-3736201:+","gi|4885645|ref|NP_005418.1|",3268,0,"tumor protein p73 isoform a [Homo sapiens]","gi|323668313|ref|NM_005427.3|",5143,0,"Homo sapiens tumor protein p73 (TP73), transcript variant 1, mRNA","O15350",1223,0,"Tumor protein p73",".",".",".",".","pfam00870","P53","P53 DNA-binding domain. This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.","GO:0000187|activation of MAPK activity;GO:0007050|cell cycle arrest;GO:0006974|cellular response to DNA damage stimulus;GO:0034644|cellular response to UV;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0001822|kidney development;GO:0006298|mismatch repair;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0043508|negative regulation of JUN kinase activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0045665|negative regulation of neuron differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0071158|positive regulation of cell cycle arrest;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:1900740|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051262|protein tetramerization;GO:0042981|regulation of apoptotic process;GO:0010468|regulation of gene expression;GO:1902036|regulation of hematopoietic stem cell differentiation;GO:0007346|regulation of mitotic cell cycle;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0042493|response to drug;GO:0010332|response to gamma radiation;GO:0010243|response to organonitrogen compound;GO:0010165|response to X-ray;GO:0016032|viral process;","GO:0030054|cell junction;GO:0000785|chromatin;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042802|identical protein binding;GO:0097371|MDM2/MDM4 family protein binding;GO:0046872|metal ion binding;GO:0002039|p53 binding;GO:0019901|protein kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K10148","TP73; tumor protein p73"]
["ENSG00000267500",8,15,5,18.0334534393454,23,30,33,0.386124922296033,-1.37286041936307,0.00559236688006826,0.0157467988879937,"down","yes","ZNF887P","transcribed_unprocessed_pseudogene","chr19:11648364-11652877:+","gi|694973081|ref|XP_009433012.1|",2324,0,"PREDICTED: zinc finger protein 20-like isoform X1 [Pan troglodytes]","gi|694973084|ref|XM_009434739.1|",1350,0,"PREDICTED: Pan troglodytes zinc finger protein 20-like (LOC455735), transcript variant X3, mRNA","P17024",549,0,"Zinc finger protein 20",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000123080",416,443,388,805.022365292184,1031,1235,1593,0.385459129962187,-1.37535019486812,1.54392631962219e-71,6.58832983470639e-70,"down","yes","CDKN2C","protein_coding","chr1:50960745-50974633:+","gi|4502751|ref|NP_001253.1|",796,2e-96,"cyclin-dependent kinase 4 inhibitor C [Homo sapiens]","gi|21749475|dbj|AK091170.1|",2890,0,"Homo sapiens cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR","P42773",311,8e-98,"Cyclin-dependent kinase 4 inhibitor C","all2748",65.5,3e-10,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0007050|cell cycle arrest;GO:0000082|G1/S transition of mitotic cell cycle;GO:0030308|negative regulation of cell growth;GO:0008285|negative regulation of cell proliferation;GO:0031658|negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0042326|negative regulation of phosphorylation;GO:0048709|oligodendrocyte differentiation;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0019901|protein kinase binding;","K06622","CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C"]
["ENSG00000203706",72,83,59,137.976363944753,173,214,276,0.385239829337929,-1.37617122603159,9.16649143222311e-15,8.42321518555118e-14,"down","yes","SERTAD4-AS1","antisense","chr1:210231456-210234047:-","gi|426333674|ref|XP_004028397.1|",375,1e-38,"PREDICTED: uncharacterized protein LOC101127914 [Gorilla gorilla gorilla]","gi|551899119|tpe|HG493150.1|",726,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000088581.1 (C1orf133 gene), antisense",".",".",".",".",".",".",".",".","pfam12526","DUF3729","Protein of unknown function (DUF3729). This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.",".",".",".",".","."]
["ENSG00000117152",19,20,24,40.8743808884302,57,56,82,0.385188024110443,-1.37636524587281,1.95467303181974e-05,8.23541577932268e-05,"down","yes","RGS4","protein_coding","chr1:163068775-163076802:+","gi|62087618|dbj|BAD92256.1|",725,8e-86,"regulator of G-protein signaling 4 variant [Homo sapiens]","gi|21755635|dbj|AK096204.1|",3741,0,"Homo sapiens cDNA FLJ38885 fis, clone MESAN2017417, moderately similar to REGULATOR OF G-PROTEIN SIGNALING 4","Q5R747",169,2e-45,"Regulator of G-protein signaling 4",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;",".","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSG00000157470",108,80,83,175.022360180143,248,254,330,0.384597450955435,-1.37857889410799,1.3299620906941e-17,1.41257207077686e-16,"down","yes","FAM81A","protein_coding","chr15:59372693-59523549:+","gi|148613880|ref|NP_689663.2|",1924,0,"protein FAM81A [Homo sapiens]","gi|148613879|ref|NM_152450.2|",3465,0,"Homo sapiens family with sequence similarity 81 member A (FAM81A), mRNA",".",".",".",".",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSG00000198899",15328,15645,13856,28995.7149398275,33073,47397,60129,0.38438382850788,-1.37938045342255,7.59097769086954e-55,2.43618598504978e-53,"down","yes","MT-ATP6","protein_coding","chrMT:8527-9207:+","gi|513789137|gb|AGO22236.1|",698,3e-89,"ATP synthase F0 subunit 6 (mitochondrion) [Homo sapiens]","gi|933907744|gb|KT828339.1|",681,0,"Homo sapiens haplogroup H2a2a1 mitochondrion, complete genome","P00846",272,2e-90,"ATP synthase subunit a","RP023",68.6,2e-13,"COG0356","pfam00119","ATP-synt_A","ATP synthase A chain.","GO:0007568|aging;GO:0006754|ATP biosynthetic process;GO:0042407|cristae formation;GO:0042776|mitochondrial ATP synthesis coupled proton transport;GO:0055093|response to hyperoxia;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005753|mitochondrial proton-transporting ATP synthase complex;GO:0045263|proton-transporting ATP synthase complex, coupling factor F(o);","GO:0015078|hydrogen ion transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K02126","ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a"]
["ENSG00000169689",635,560,519,1107.7228303797,1511,1622,2157,0.384233989806529,-1.37994294767902,5.32833126475306e-84,2.77764468742046e-82,"down","yes","CENPX","protein_coding","chr17:82018702-82024107:-","gi|530413460|ref|XP_005256396.1|",630,2e-79,"PREDICTED: centromere protein X isoform X1 [Homo sapiens]","gi|767997325|ref|XM_005256339.2|",681,0,"PREDICTED: Homo sapiens stimulated by retinoic acid 13 (STRA13), transcript variant X1, mRNA","A8MT69",72,1e-14,"Centromere protein X",".",".",".",".","pfam09415","CENP-X","CENP-S associating Centromere protein X. The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.","GO:0051301|cell division;GO:0034080|CENP-A containing nucleosome assembly;GO:0036297|interstrand cross-link repair;GO:0051382|kinetochore assembly;GO:0031398|positive regulation of protein ubiquitination;GO:0031297|replication fork processing;GO:0000712|resolution of meiotic recombination intermediates;","GO:0000777|condensed chromosome kinetochore;GO:0071821|FANCM-MHF complex;GO:0043240|Fanconi anaemia nuclear complex;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;","K15360","STRA13, CENPX, MHF2; centromere protein X"]
["ENSG00000142945",1053,933,893,1860.74259884348,2249,3072,3633,0.383791379739513,-1.38160578707142,9.07541741046664e-137,8.97675133400413e-135,"down","yes","KIF2C","protein_coding","chr1:44739818-44767767:+","gi|663071033|ref|NP_001284585.1|",3537,0,"kinesin-like protein KIF2C isoform 3 [Homo sapiens]","gi|663071032|ref|NM_001297656.1|",2955,0,"Homo sapiens kinesin family member 2C (KIF2C), transcript variant 3, mRNA","Q99661",1365,0,"Kinesin-like protein KIF2C","ECU11g0470",239,5e-67,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051301|cell division;GO:0008283|cell proliferation;GO:0030951|establishment or maintenance of microtubule cytoskeleton polarity;GO:0051310|metaphase plate congression;GO:0007019|microtubule depolymerization;GO:0007018|microtubule-based movement;GO:0000278|mitotic cell cycle;GO:0007080|mitotic metaphase plate congression;GO:0051983|regulation of chromosome segregation;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0000776|kinetochore;GO:0016020|membrane;GO:0015630|microtubule cytoskeleton;GO:0035371|microtubule plus-end;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0019237|centromeric DNA binding;GO:0003777|microtubule motor activity;GO:0051010|microtubule plus-end binding;","K10393","KIF2_24, MCAK; kinesin family member 2/24"]
["ENSG00000198886",42413,43405,40545,81920.2299019405,100839,132877,160165,0.38369170728454,-1.3819805105272,0,0,"down","yes","MT-ND4","protein_coding","chrMT:10760-12137:+","gi|545768783|gb|AGW71683.1|",1338,8e-179,"NADH dehydrogenase subunit 4 (mitochondrion) [Homo sapiens]","gi|1001887523|gb|KU761989.1|",1378,0,"Homo sapiens haplogroup H63 mitochondrion, complete genome","P03905",518,1e-179,"NADH-ubiquinone oxidoreductase chain 4","XF0317",147,5e-38,"COG1008","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0007568|aging;GO:0021549|cerebellum development;GO:0001701|in utero embryonic development;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0045471|response to ethanol;GO:0001666|response to hypoxia;GO:0035094|response to nicotine;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03881","ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:1.6.5.3]"]
["ENSG00000163545",49,66,40,100.471215294327,131,157,193,0.383129986024707,-1.38409415083745,7.6443014549873e-11,5.46086246162204e-10,"down","yes","NUAK2","protein_coding","chr1:205302059-205321791:-","gi|733214996|ref|NP_112214.2|",3021,0,"NUAK family SNF1-like kinase 2 [Homo sapiens]","gi|733214995|ref|NM_030952.2|",3434,0,"Homo sapiens NUAK family kinase 2 (NUAK2), mRNA","Q9H093",1133,0,"NUAK family SNF1-like kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0030036|actin cytoskeleton organization;GO:0006915|apoptotic process;GO:0042149|cellular response to glucose starvation;GO:0035556|intracellular signal transduction;GO:0043066|negative regulation of apoptotic process;GO:0006468|protein phosphorylation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K08800","NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]"]
["ENSG00000163808",423,424,372,789.988667659431,989,1281,1522,0.38297424733875,-1.38468071183846,3.49601910112978e-74,1.55014290626646e-72,"down","yes","KIF15","protein_coding","chr3:44761717-44873376:+","gi|9910266|ref|NP_064627.1|",6981,0,"kinesin-like protein KIF15 [Homo sapiens]","gi|193211423|ref|NM_020242.2|",4837,0,"Homo sapiens kinesin family member 15 (KIF15), mRNA","Q9NS87",2693,0,"Kinesin-like protein KIF15","SPAC1834.07",231,2e-63,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0008283|cell proliferation;GO:0007018|microtubule-based movement;GO:0000278|mitotic cell cycle;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0005874|microtubule;GO:0005873|plus-end kinesin complex;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003677|DNA binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0003774|motor activity;","K10400","KIF15; kinesin family member 15"]
["ENSG00000062822",1062,1120,970,2046.43130875511,2607,3205,4018,0.382350762073488,-1.38703134532931,1.39717527373862e-150,1.61369560957308e-148,"down","yes","POLD1","protein_coding","chr19:50384204-50418016:+","gi|821174304|ref|NP_001295561.1|",5361,0,"DNA polymerase delta catalytic subunit 2 [Homo sapiens]","gi|821174303|ref|NM_001308632.1|",3465,0,"Homo sapiens polymerase (DNA) delta 1, catalytic subunit (POLD1), transcript variant 4, mRNA","P28340",2003,0,"DNA polymerase delta catalytic subunit","SPBC336.04",1103,0,"COG0417","pfam00136","DNA_pol_B","DNA polymerase family B. This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.","GO:0006287|base-excision repair, gap-filling;GO:0034644|cellular response to UV;GO:0042769|DNA damage response, detection of DNA damage;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0045004|DNA replication proofreading;GO:0000731|DNA synthesis involved in DNA repair;GO:0055089|fatty acid homeostasis;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0009411|response to UV;GO:0000723|telomere maintenance;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0016235|aggresome;GO:0005829|cytosol;GO:0043625|delta DNA polymerase complex;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0000109|nucleotide-excision repair complex;GO:0005634|nucleus;","GO:0008296|3'-5'-exodeoxyribonuclease activity;GO:0051539|4 iron, 4 sulfur cluster binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0046872|metal ion binding;GO:0000166|nucleotide binding;","K02327","POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"]
["ENSG00000099994",129,140,110,246.034010454049,313,379,492,0.38186366994748,-1.38887042467763,2.09377800281075e-25,3.14034137777712e-24,"down","yes","SUSD2","protein_coding","chr22:24181259-24189110:+","gi|119580046|gb|EAW59642.1|",2241,0,"sushi domain containing 2, isoform CRA_b [Homo sapiens]","gi|34532479|dbj|AK126105.1|",4938,0,"Homo sapiens cDNA FLJ44117 fis, clone TESTI4046903","Q9UGT4",841,0,"Sushi domain-containing protein 2",".",".",".",".","pfam03782","AMOP","AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.","GO:0006955|immune response;GO:1902807|negative regulation of cell cycle G1/S phase transition;GO:0051782|negative regulation of cell division;","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0030247|polysaccharide binding;GO:0005044|scavenger receptor activity;",".","."]
["ENSG00000108852",281,214,260,491.410126675197,646,737,978,0.380867602798692,-1.39263851969146,6.56319630739491e-43,1.63765757279473e-41,"down","yes","MPP2","protein_coding","chr17:43875357-43909711:-","gi|507834101|ref|NP_001265299.1|",2963,0,"MAGUK p55 subfamily member 2 isoform 1 [Homo sapiens]","gi|507834135|ref|NM_001278381.1|",4938,0,"Homo sapiens membrane protein, palmitoylated 2 (MPP2), transcript variant 9, mRNA","Q14168",1122,0,"MAGUK p55 subfamily member 2","YDR454c",93.6,7e-20,"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0051260|protein homooligomerization;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0032590|dendrite membrane;GO:0043198|dendritic shaft;GO:0043197|dendritic spine;GO:0032591|dendritic spine membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0014069|postsynaptic density;","GO:0004385|guanylate kinase activity;",".","."]
["ENSG00000180096",8,6,6,13.0134369919005,19,18,25,0.380853315547925,-1.39269263963312,0.0130138133538699,0.0337448553144451,"down","yes","2020-09-01","protein_coding","chr16:30378133-30395991:-","gi|194382552|dbj|BAG64446.1|",916,2e-113,"unnamed protein product [Homo sapiens]","gi|21733593|emb|AL833004.1|",2345,0,"Homo sapiens mRNA; cDNA DKFZp666C094 (from clone DKFZp666C094)","Q8WYJ6",338,1e-105,"Septin-1","SPAC821.06",123,8e-35,"COG5019","pfam00735","Septin","Septin. Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0030496|midbody;","GO:0005525|GTP binding;GO:0042802|identical protein binding;","K13737","SEPT1; septin 1"]
["ENSG00000174871",15,25,24,42.1283478569686,63,61,75,0.380300789950342,-1.39478715918928,2.06829112559563e-05,8.69511753062088e-05,"down","yes","CNIH2","protein_coding","chr11:66278190-66285301:+","gi|830010923|ref|XP_012612935.1|",745,2e-92,"PREDICTED: protein cornichon homolog 2 [Microcebus murinus]","gi|17939943|dbj|AP001107.5|",948,0,"Homo sapiens genomic DNA, chromosome 11q clone:RP11-867G23, complete sequences","Q5BJU5",289,9e-94,"Protein cornichon homolog 2",".",".",".",".","pfam03311","Cornichon","Cornichon protein.","GO:0051668|localization within membrane;GO:1903743|negative regulation of anterograde synaptic vesicle transport;GO:1902684|negative regulation of receptor localization to synapse;GO:2000311|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:0042391|regulation of membrane potential;GO:2000310|regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:0035249|synaptic transmission, glutamatergic;GO:0016192|vesicle-mediated transport;","GO:0032281|AMPA glutamate receptor complex;GO:0030054|cell junction;GO:0030425|dendrite;GO:0043198|dendritic shaft;GO:0043197|dendritic spine;GO:0005789|endoplasmic reticulum membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;",".",".","."]
["ENSG00000105270",4,9,15,18.620441113781,25,37,25,0.380255713699839,-1.39495816892446,0.00701438284591871,0.0193221103016396,"down","yes","CLIP3","protein_coding","chr19:36014660-36033343:-","gi|958686651|ref|XP_014693788.1|",2568,0,"PREDICTED: CAP-Gly domain-containing linker protein 3 isoform X1 [Equus asinus]","gi|313851095|ref|NM_015526.2|",3370,0,"Homo sapiens CAP-Gly domain containing linker protein 3 (CLIP3), transcript variant 2, mRNA","Q96DZ5",971,0,"CAP-Gly domain-containing linker protein 3","SPAC27D7.13c",74.7,9e-13,"COG5244","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0072321|chaperone-mediated protein transport;GO:0045444|fat cell differentiation;GO:0044091|membrane biogenesis;GO:0031115|negative regulation of microtubule polymerization;GO:0018230|peptidyl-L-cysteine S-palmitoylation;GO:0043065|positive regulation of apoptotic process;GO:0045807|positive regulation of endocytosis;GO:0010828|positive regulation of glucose transport;GO:1903078|positive regulation of protein localization to plasma membrane;GO:0001934|positive regulation of protein phosphorylation;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;","GO:0005829|cytosol;GO:0031901|early endosome membrane;GO:0005795|Golgi stack;GO:0045121|membrane raft;GO:0005886|plasma membrane;GO:0055038|recycling endosome membrane;GO:0005802|trans-Golgi network;GO:0032588|trans-Golgi network membrane;","GO:0035594|ganglioside binding;GO:0008017|microtubule binding;","K10423","CLIP3_4; CAP-Gly domain-containing linker protein 3/4"]
["ENSG00000153012",8,7,4,12.257672808728,12,23,25,0.380178759415462,-1.39525016401082,0.0171006472877519,0.0429307932950878,"down","yes","LGI2","protein_coding","chr4:24998847-25030879:-","gi|21313638|ref|NP_060646.2|",2701,0,"leucine-rich repeat LGI family member 2 precursor [Homo sapiens]","gi|195539333|ref|NM_018176.3|",6339,0,"Homo sapiens leucine-rich repeat LGI family member 2 (LGI2), mRNA","Q1EGL1",1043,0,"Leucine-rich repeat LGI family member 2",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005576|extracellular region;",".",".","."]
["ENSG00000137404",141,94,140,244.649028315784,301,370,515,0.379392371629892,-1.39823742384057,3.82534612574664e-21,4.79423496253419e-20,"down","yes","NRM","protein_coding","chr6:30688047-30691420:-","gi|18204632|gb|AAH21260.1|",1022,2e-132,"Unknown (protein for IMAGE:4135057), partial [Homo sapiens]","gi|399124749|ref|NM_007243.2|",1755,0,"Homo sapiens nurim (nuclear envelope membrane protein) (NRM), transcript variant 1, mRNA","Q1XHX8",398,9e-134,"Nurim",".",".",".",".","pfam07298","NnrU","NnrU protein. This family consists of several plant and bacterial NnrU proteins. NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that NnrU and perhaps NnrT are required for expression of both nirK and nor.",".","GO:0016021|integral component of membrane;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;",".",".","."]
["ENSG00000118523",8642,8615,7989,16500.591141751,21232,25742,32442,0.379004682658684,-1.39971242167113,0,0,"down","yes","CTGF","protein_coding","chr6:131948176-131951373:-","gi|116241320|sp|P29279.2|CTGF_HUMAN",1808,0,"RecName: Full=Connective tissue growth factor; AltName: Full=CCN family member 2; AltName: Full=Hypertrophic chondrocyte-specific protein 24; AltName: Full=Insulin-like growth factor-binding protein 8; Short=IBP-8; Short=IGF-binding protein 8; Short=IGFBP-8; Flags: Precursor","gi|98986335|ref|NM_001901.2|",2330,0,"Homo sapiens connective tissue growth factor (CTGF), mRNA","P29279",701,0,"Connective tissue growth factor",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.","GO:0007568|aging;GO:0001525|angiogenesis;GO:0001502|cartilage condensation;GO:0007155|cell adhesion;GO:0030154|cell differentiation;GO:0016477|cell migration;GO:0007267|cell-cell signaling;GO:0007160|cell-matrix adhesion;GO:0035988|chondrocyte proliferation;GO:0060401|cytosolic calcium ion transport;GO:0071897|DNA biosynthetic process;GO:0008544|epidermis development;GO:0070278|extracellular matrix constituent secretion;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0030324|lung development;GO:0060548|negative regulation of cell death;GO:0010629|negative regulation of gene expression;GO:0001503|ossification;GO:0060452|positive regulation of cardiac muscle contraction;GO:0050867|positive regulation of cell activation;GO:0045597|positive regulation of cell differentiation;GO:0008284|positive regulation of cell proliferation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070318|positive regulation of G0 to G1 transition;GO:0010628|positive regulation of gene expression;GO:0046330|positive regulation of JNK cascade;GO:0051496|positive regulation of stress fiber assembly;GO:0072593|reactive oxygen species metabolic process;GO:0001558|regulation of cell growth;GO:0032330|regulation of chondrocyte differentiation;GO:0043200|response to amino acid;GO:0034059|response to anoxia;GO:0032355|response to estradiol;GO:0070542|response to fatty acid;GO:0009749|response to glucose;GO:0051385|response to mineralocorticoid;GO:0043434|response to peptide hormone;GO:0009611|response to wounding;GO:0001894|tissue homeostasis;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005938|cell cortex;GO:0005801|cis-Golgi network;GO:0005829|cytosol;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0001968|fibronectin binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0005520|insulin-like growth factor binding;GO:0005178|integrin binding;GO:0008022|protein C-terminus binding;","K06827","CTGF; connective tissue growth factor"]
["ENSG00000213967",7,6,7,12.9471428624315,9,20,37,0.378424510361265,-1.40192256056664,0.0176124267517923,0.0440255757038558,"down","yes","ZNF726","protein_coding","chr19:23914876-23945159:+","gi|982312101|ref|XP_015295933.1|",3494,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 726 [Macaca fascicularis]","gi|931605561|ref|XM_014342583.1|",2345,0,"PREDICTED: Pan paniscus zinc finger protein 726 (LOC100995955), mRNA","A6NNF4",1333,0,"Zinc finger protein 726",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000242265",2168,1931,1736,3813.28336485558,5085,5949,7251,0.378061662756565,-1.40330653425617,9.74781223544487e-219,1.97911370944485e-216,"down","yes","PEG10","protein_coding","chr7:94656325-94669695:+","gi|289176998|ref|NP_001165909.1|",1728,0,"retrotransposon-derived protein PEG10 isoform 4 [Homo sapiens]","gi|94421472|ref|NM_001040152.1|",6618,0,"Homo sapiens paternally expressed 10 (PEG10), transcript variant 1, mRNA","Q86TG7",639,0,"Retrotransposon-derived protein PEG10",".",".",".",".","pfam03732","Retrotrans_gag","Retrotransposon gag protein. Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved.","GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["ENSG00000198901",8,7,8,15.0996637369107,19,28,25,0.377775473737697,-1.40439905400169,0.00725656785695811,0.0199266345138109,"down","yes","PRC1","protein_coding","chr15:90966038-90995629:-","gi|40807443|ref|NP_955445.1|",2995,0,"protein regulator of cytokinesis 1 isoform 2 [Homo sapiens]","gi|389886542|ref|NM_199413.2|",3106,0,"Homo sapiens protein regulator of cytokinesis 1 (PRC1), transcript variant 2, mRNA","O43663",1151,0,"Protein regulator of cytokinesis 1",".",".",".",".","pfam03999","MAP65_ASE1","Microtubule associated protein (MAP65/ASE1 family).","GO:0000910|cytokinesis;GO:0001578|microtubule bundle formation;GO:0000022|mitotic spindle elongation;GO:0008284|positive regulation of cell proliferation;GO:0032465|regulation of cytokinesis;","GO:0070938|contractile ring;GO:0005829|cytosol;GO:0030496|midbody;GO:0005634|nucleus;GO:0005819|spindle;GO:0005876|spindle microtubule;GO:0000922|spindle pole;","GO:0042802|identical protein binding;GO:0019894|kinesin binding;GO:0008017|microtubule binding;GO:0019901|protein kinase binding;","K16732","PRC1; protein regulator of cytokinesis 1"]
["ENSG00000013810",1454,1454,1420,2836.46900259165,3613,4396,5679,0.377755683487088,-1.4044746334034,9.16079903412093e-196,1.62104120890023e-193,"down","yes","TACC3","protein_coding","chr4:1721490-1745176:+","gi|5454102|ref|NP_006333.1|",4085,0,"transforming acidic coiled-coil-containing protein 3 [Homo sapiens]","gi|355477277|ref|NM_006342.2|",2781,0,"Homo sapiens transforming acidic coiled-coil containing protein 3 (TACC3), mRNA","Q9Y6A5",1577,0,"Transforming acidic coiled-coil-containing protein 3",".",".",".",".","pfam05010","TACC","Transforming acidic coiled-coil-containing protein (TACC). This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organizing centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumor suppressor (AZU-1). The functional homologue (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0021987|cerebral cortex development;GO:0007091|metaphase/anaphase transition of mitotic cell cycle;GO:1902850|microtubule cytoskeleton organization involved in mitosis;GO:0060236|regulation of mitotic spindle organization;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;GO:0005815|microtubule organizing center;GO:0072686|mitotic spindle;GO:0000922|spindle pole;",".","K14283","TACC3, maskin; transforming acidic coiled-coil-containing protein 3"]
["ENSG00000166803",248,222,174,419.564320596246,481,657,913,0.377608978554306,-1.40503502626342,1.14001488071278e-33,2.24832382609285e-32,"down","yes","PCLAF","protein_coding","chr15:64364311-64387687:-","gi|752385483|ref|XP_002914287.2|",556,2e-63,"PREDICTED: PCNA-associated factor isoform X2 [Ailuropoda melanoleuca]","gi|24137591|gb|AC087632.10|",1765,0,"Homo sapiens chromosome 15, clone RP11-236P11, complete sequence","Q15004",196,1e-57,"PCNA-associated factor",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006974|cellular response to DNA damage stimulus;GO:0007098|centrosome cycle;GO:0006260|DNA replication;GO:0051726|regulation of cell cycle;GO:0009411|response to UV;GO:0019985|translesion synthesis;","GO:0005813|centrosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0003682|chromatin binding;",".","."]
["ENSG00000175322",43,33,45,79.6909515244614,120,118,139,0.377302088303173,-1.40620800964447,4.04827632567709e-09,2.46786200283374e-08,"down","yes","ZNF519","protein_coding","chr18:14057457-14132490:-","gi|119621907|gb|EAX01502.1|",571,6e-64,"hCG2038802, partial [Homo sapiens]","gi|21728136|dbj|AP001004.5|",6407,0,"Homo sapiens genomic DNA, chromosome 18 clone:RP11-681B3, complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000143228",590,518,549,1088.2810422151,1417,1766,2043,0.376573190512969,-1.40899780149592,2.73655927260609e-97,1.72492664215772e-95,"down","yes","NUF2","protein_coding","chr1:163266576-163355764:+","gi|117968353|ref|NP_113611.2|",2454,0,"kinetochore protein Nuf2 [Homo sapiens]","gi|117968419|ref|NM_145697.2|",1968,0,"Homo sapiens NUF2, NDC80 kinetochore complex component (NUF2), transcript variant 1, mRNA","Q9BZD4",949,0,"Kinetochore protein Nuf2",".",".",".",".","pfam03800","Nuf2","Nuf2 family. Members of this family are components of the mitotic spindle. It has been shown that Nuf2 from yeast is part of a complex called the Ndc80p complex. This complex is thought to bind to the microtubules of the spindle. An arabidopsis protein has been included in this family that has previously not been identified as a member of this family. The match is not strong, but in common with other members of this family contains coiled-coil to the C terminus of this region.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0007059|chromosome segregation;","GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0016020|membrane;GO:0031262|Ndc80 complex;GO:0005634|nucleus;",".","K11548","NUF2, CDCA1; kinetochore protein Nuf2"]
["ENSG00000135617",225,224,220,440.223551222,549,675,912,0.375152476726654,-1.41445101205858,6.41845503395506e-44,1.64189868295657e-42,"down","yes","PRADC1","protein_coding","chr2:73228006-73233238:-","gi|982290006|ref|XP_005575653.2|",1024,4e-136,"PREDICTED: protease-associated domain-containing protein 1 [Macaca fascicularis]","gi|14150089|ref|NM_032319.1|",1083,0,"Homo sapiens protease-associated domain containing 1 (PRADC1), mRNA","Q9BSG0",391,2e-135,"Protease-associated domain-containing protein 1",".",".",".",".","pfam02225","PA","PA domain. The PA (Protease associated) domain is found as an insert domain in diverse proteases. The PA domain is also found in a plant vacuolar sorting receptor and members of the RZF family. It has been suggested that this domain forms a lid-like structure that covers the active site in active proteases, and is involved in protein recognition in vacuolar sorting receptors.",".","GO:0005576|extracellular region;",".",".","."]
["ENSG00000136237",154,182,147,318.874735083582,394,526,623,0.373781609817431,-1.41973250514581,5.8741832938048e-32,1.10862277270946e-30,"down","yes","RAPGEF5","protein_coding","chr7:22118238-22357144:-","gi|530385121|ref|XP_005249971.1|",4087,0,"PREDICTED: rap guanine nucleotide exchange factor 5 isoform X2 [Homo sapiens]","gi|119392076|ref|NM_012294.3|",6621,0,"Homo sapiens Rap guanine nucleotide exchange factor 5 (RAPGEF5), mRNA","Q8C0Q9",1418,0,"Rap guanine nucleotide exchange factor 5",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0030742|GTP-dependent protein binding;GO:0017034|Rap guanyl-nucleotide exchange factor activity;","K08019","RAPGEF5; Rap guanine nucleotide exchange factor 5"]
["ENSG00000139734",502,470,438,930.903746252002,1256,1459,1757,0.373766280469066,-1.41979167346173,2.80951106997413e-88,1.57072027587423e-86,"down","yes","DIAPH3","protein_coding","chr13:59665583-60163987:-","gi|110225351|ref|NP_001035982.1|",5257,0,"protein diaphanous homolog 3 isoform a [Homo sapiens]","gi|110225350|ref|NM_001042517.1|",4802,0,"Homo sapiens diaphanous related formin 3 (DIAPH3), transcript variant 1, mRNA","Q9NSV4",2029,0,"Protein diaphanous homolog 3",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0030036|actin cytoskeleton organization;GO:0007283|spermatogenesis;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0003779|actin binding;GO:0045296|cadherin binding;GO:0017048|Rho GTPase binding;","K05745","DIAPH3, DRF3; diaphanous 3"]
["ENSG00000117399",1905,1842,1802,3671.50367544626,4688,5752,7340,0.37259510719594,-1.42431936550985,1.19644697164288e-262,3.44433868493251e-260,"down","yes","CDC20","protein_coding","chr1:43358955-43363203:+","gi|118402582|ref|NP_001246.2|",2487,0,"cell division cycle protein 20 homolog [Homo sapiens]","gi|33875656|gb|BC000624.2|",1679,0,"Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:3076 IMAGE:3346682), complete cds","Q12834",962,0,"Cell division cycle protein 20 homolog",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0051301|cell division;GO:0007064|mitotic sister chromatid cohesion;GO:0090307|mitotic spindle assembly;GO:0008284|positive regulation of cell proliferation;GO:0090129|positive regulation of synapse maturation;GO:0031915|positive regulation of synaptic plasticity;GO:1904668|positive regulation of ubiquitin protein ligase activity;GO:0016579|protein deubiquitination;GO:0016567|protein ubiquitination;GO:0050773|regulation of dendrite development;GO:0040020|regulation of meiotic nuclear division;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0032991|macromolecular complex;GO:0005819|spindle;GO:0000922|spindle pole;","GO:0010997|anaphase-promoting complex binding;GO:0019899|enzyme binding;GO:0042826|histone deacetylase binding;GO:0008022|protein C-terminus binding;GO:0097027|ubiquitin-protein transferase activator activity;","K03363","CDC20; cell division cycle 20, cofactor of APC complex"]
["ENSG00000214826",269,235,252,500.952459202098,647,848,915,0.372137774594922,-1.4260912533225,2.26977891717484e-48,6.38185069307119e-47,"down","yes","DDX12P","unprocessed_pseudogene","chr12:9418673-9448229:-","gi|578822789|ref|XP_006719107.1|",3642,0,"PREDICTED: probable ATP-dependent RNA helicase DDX11 isoform X4 [Homo sapiens]","gi|291219889|ref|NR_033399.1|",1191,0,"Homo sapiens DEAD/H-box helicase 12, pseudogene (DDX12P), non-coding RNA","Q96FC9",1340,0,"ATP-dependent DNA helicase DDX11","SPAC3G6.11",313,6e-111,"COG1199","pfam06733","DEAD_2","DEAD_2. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.","GO:0072719|cellular response to cisplatin;GO:0006974|cellular response to DNA damage stimulus;GO:0072711|cellular response to hydroxyurea;GO:0032508|DNA duplex unwinding;GO:0006281|DNA repair;GO:0044806|G-quadruplex DNA unwinding;GO:0036498|IRE1-mediated unfolded protein response;GO:0007275|multicellular organismal development;GO:0032091|negative regulation of protein binding;GO:1990700|nucleolar chromatin organization;GO:0035563|positive regulation of chromatin binding;GO:2000781|positive regulation of double-strand break repair;GO:0032079|positive regulation of endodeoxyribonuclease activity;GO:0045876|positive regulation of sister chromatid cohesion;GO:1901838|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:0031297|replication fork processing;GO:0007062|sister chromatid cohesion;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0001650|fibrillar center;GO:0030496|midbody;GO:0000790|nuclear chromatin;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0005524|ATP binding;GO:0004003|ATP-dependent DNA helicase activity;GO:0008026|ATP-dependent helicase activity;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003688|DNA replication origin binding;GO:0008094|DNA-dependent ATPase activity;GO:0003690|double-stranded DNA binding;GO:0051880|G-quadruplex DNA binding;GO:0004386|helicase activity;GO:0046872|metal ion binding;GO:0008186|RNA-dependent ATPase activity;GO:0003697|single-stranded DNA binding;GO:0003727|single-stranded RNA binding;GO:0045142|triplex DNA binding;","K11273","DDX11, CHL1, CTF1; chromosome transmission fidelity protein 1 [EC:3.6.4.13]"]
["ENSG00000163009",48,31,33,73.8059516584962,94,116,148,0.372126899111749,-1.42613341575798,3.47517516177975e-09,2.13400759377293e-08,"down","yes","C2orf48","lincRNA","chr2:10141382-10211725:+","gi|32699062|ref|NP_872432.1|",830,2e-104,"uncharacterized protein C2orf48 [Homo sapiens]","gi|723276205|ref|NM_182626.3|",1897,0,"Homo sapiens chromosome 2 open reading frame 48 (C2orf48), mRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000131351",199,239,188,415.165385290704,545,648,812,0.371804730785862,-1.42738296788472,9.46725268502478e-40,2.20536678488838e-38,"down","yes","HAUS8","protein_coding","chr19:17049729-17075625:-","gi|58761504|ref|NP_219485.1|",1778,0,"HAUS augmin-like complex subunit 8 isoform a [Homo sapiens]","gi|26996686|gb|BC040564.1|",3176,0,"Homo sapiens sarcoma antigen NY-SAR-48, mRNA (cDNA clone IMAGE:5266883), with apparent retained intron","Q9BT25",689,0,"HAUS augmin-like complex subunit 8",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0051301|cell division;GO:0007098|centrosome cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0070652|HAUS complex;GO:0005874|microtubule;GO:0000922|spindle pole;",".","K16591","HAUS8; HAUS augmin-like complex subunit 8"]
["ENSG00000185924",23,10,8,26.7766070654586,33,41,57,0.371452017231575,-1.42875223398336,0.000596654550435347,0.00202467856593895,"down","yes","RTN4RL1","protein_coding","chr17:1934677-2025345:-","gi|30425553|ref|NP_848663.1|",1999,0,"reticulon-4 receptor-like 1 precursor [Homo sapiens]","gi|737674763|ref|NM_178568.3|",3625,0,"Homo sapiens reticulon 4 receptor-like 1 (RTN4RL1), mRNA","Q86UN2",774,0,"Reticulon-4 receptor-like 1","SPy1798",70.5,3e-11,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0031103|axon regeneration;GO:0022038|corpus callosum development;GO:0019221|cytokine-mediated signaling pathway;GO:0048681|negative regulation of axon regeneration;GO:0046426|negative regulation of JAK-STAT cascade;GO:0010977|negative regulation of neuron projection development;GO:0006469|negative regulation of protein kinase activity;","GO:0046658|anchored component of plasma membrane;GO:0042995|cell projection;GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0045121|membrane raft;GO:0043204|perikaryon;GO:0005886|plasma membrane;","GO:0035374|chondroitin sulfate binding;GO:0008201|heparin binding;GO:0004860|protein kinase inhibitor activity;GO:0038023|signaling receptor activity;","K16660","RTN4RL1, NGR3; reticulon-4 receptor-like 1"]
["ENSG00000166801",451,424,373,826.641884050406,1040,1329,1641,0.37105279292423,-1.43030362860339,3.027890332358e-82,1.53285954673284e-80,"down","yes","FAM111A","protein_coding","chr11:59142748-59155039:+","gi|38505209|ref|NP_071357.2|",3291,0,"protein FAM111A [Homo sapiens]","gi|51476441|emb|CR749358.1|",4195,0,"Homo sapiens mRNA; cDNA DKFZp686A06175 (from clone DKFZp686A06175)","Q96PZ2",1272,0,"Protein FAM111A",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0051607|defense response to virus;GO:0006260|DNA replication;GO:0045071|negative regulation of viral genome replication;GO:0016032|viral process;","GO:0000785|chromatin;GO:0005737|cytoplasm;GO:0001650|fibrillar center;GO:0005634|nucleus;",".",".","."]
["ENSG00000125384",63,46,56,109.540057601309,143,181,204,0.370701910621305,-1.43166854396882,5.00177050194552e-13,4.12635369724231e-12,"down","yes","PTGER2","protein_coding","chr14:52314305-52328606:+","gi|31881630|ref|NP_000947.2|",1412,0,"prostaglandin E2 receptor EP2 subtype [Homo sapiens]","gi|194473721|ref|NM_000956.3|",2383,0,"Homo sapiens prostaglandin E receptor 2 (PTGER2), mRNA","P43116",548,0,"Prostaglandin E2 receptor EP2 subtype",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0071380|cellular response to prostaglandin E stimulus;GO:0007186|G-protein coupled receptor signaling pathway;GO:0042127|regulation of cell proliferation;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;","GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0004957|prostaglandin E receptor activity;","K04259","PTGER2; prostaglandin E receptor 2"]
["ENSG00000164045",383,352,401,755.258132051291,915,1196,1574,0.370269326683772,-1.43335305408454,7.9084039523762e-63,2.88896392866349e-61,"down","yes","CDC25A","protein_coding","chr3:48157146-48188402:-","gi|42490758|ref|NP_001780.2|",2652,0,"M-phase inducer phosphatase 1 isoform a [Homo sapiens]","gi|767924793|ref|XM_006713434.2|",3740,0,"PREDICTED: Homo sapiens cell division cycle 25A (CDC25A), transcript variant X2, mRNA","P30304",1026,0,"M-phase inducer phosphatase 1","SPAC24H6.05",136,2e-32,"COG5105","pfam06617","M-inducer_phosp","M-phase inducer phosphatase. This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the pfam00581 domain. These proteins are involved in the control of mitosis.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0034644|cellular response to UV;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:1902751|positive regulation of cell cycle G2/M phase transition;GO:0016579|protein deubiquitination;GO:0051726|regulation of cell cycle;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0009314|response to radiation;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0051087|chaperone binding;GO:0004721|phosphoprotein phosphatase activity;GO:0019901|protein kinase binding;GO:0004725|protein tyrosine phosphatase activity;","K06645","CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]"]
["ENSG00000166508",4405,4431,4129,8629.69988460304,11215,13477,17121,0.369714727354566,-1.43551558136434,0,0,"down","yes","MCM7","protein_coding","chr7:100092728-100101940:-","gi|33469968|ref|NP_005907.3|",3733,0,"DNA replication licensing factor MCM7 isoform 1 [Homo sapiens]","gi|518830596|ref|NM_001278595.1|",3084,0,"Homo sapiens minichromosome maintenance complex component 7 (MCM7), transcript variant 3, mRNA","P33993",1442,0,"DNA replication licensing factor MCM7","SPBC25D12.03c",645,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0008283|cell proliferation;GO:0006974|cellular response to DNA damage stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0006268|DNA unwinding involved in DNA replication;GO:0000082|G1/S transition of mitotic cell cycle;GO:0042325|regulation of phosphorylation;GO:0042493|response to drug;","GO:0000785|chromatin;GO:0005829|cytosol;GO:0042555|MCM complex;GO:0016020|membrane;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003678|DNA helicase activity;GO:0003697|single-stranded DNA binding;","K02210","MCM7, CDC47; DNA replication licensing factor MCM7 [EC:3.6.4.12]"]
["ENSG00000146410",209,214,193,410.147768901219,540,650,792,0.369603913074329,-1.43594806393684,2.47314867812292e-44,6.37728498711695e-43,"down","yes","MTFR2","protein_coding","chr6:136231024-136250335:-","gi|39653315|ref|NP_612428.2|",1852,0,"mitochondrial fission regulator 2 isoform a [Homo sapiens]","gi|973353081|ref|NM_001099286.2|",1793,0,"Homo sapiens mitochondrial fission regulator 2 (MTFR2), transcript variant 1, mRNA","Q6P444",717,0,"Mitochondrial fission regulator 2",".",".",".",".","pfam05308","Mito_fiss_reg","Mitochondrial fission regulator. In eukaryotes, this family of proteins induces mitochondrial fission.","GO:0009060|aerobic respiration;GO:0000266|mitochondrial fission;GO:0007005|mitochondrion organization;","GO:0005739|mitochondrion;",".",".","."]
["ENSG00000102385",25,26,29,53.3016353702339,64,86,110,0.369479305505478,-1.43643453344074,3.12582085030217e-07,1.60177557281159e-06,"down","yes","DRP2","protein_coding","chrX:101219769-101264497:+","gi|148539558|ref|NP_001930.2|",4927,0,"dystrophin-related protein 2 isoform 1 [Homo sapiens]","gi|694985543|ref|XM_003317553.2|",7161,0,"PREDICTED: Pan troglodytes dystrophin related protein 2 (DRP2), transcript variant X1, mRNA","Q13474",1902,0,"Dystrophin-related protein 2",".",".",".",".","pfam09068","EF-hand_2","EF hand. Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.","GO:0007417|central nervous system development;GO:0050808|synapse organization;","GO:0030054|cell junction;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0008270|zinc ion binding;",".","."]
["ENSG00000167680",751,832,725,1537.48083299953,2008,2319,3136,0.369458932860277,-1.43651408410596,1.27756859277803e-107,9.19468023041142e-106,"down","yes","SEMA6B","protein_coding","chr19:4542593-4559808:-","gi|19718780|ref|NP_115484.2|",3870,0,"semaphorin-6B precursor [Homo sapiens]","gi|312836842|ref|NM_032108.3|",3937,0,"Homo sapiens semaphorin 6B (SEMA6B), mRNA","Q9H3T3",1495,0,"Semaphorin-6B",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0030154|cell differentiation;GO:0007399|nervous system development;","GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;","K06842","SEMA6; semaphorin 6"]
["ENSG00000113368",1189,1130,1066,2254.09249452181,3011,3385,4521,0.369157509416988,-1.43769158871076,3.3759904089803e-168,4.58564105693043e-166,"down","yes","LMNB1","protein_coding","chr5:126776623-126837020:+","gi|15126742|gb|AAH12295.1|",2415,0,"Lamin B1 [Homo sapiens]","gi|968121931|ref|NR_134488.1|",3475,0,"Homo sapiens lamin B1 (LMNB1), transcript variant 3, non-coding RNA","P20700",934,0,"Lamin-B1",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0035722|interleukin-12-mediated signaling pathway;","GO:0005638|lamin filament;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0016363|nuclear matrix;GO:0031965|nuclear membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0043274|phospholipase binding;GO:0005198|structural molecule activity;","K07611","LMNB; lamin B"]
["ENSG00000164109",667,625,616,1271.64027474492,1694,1990,2460,0.369074969786536,-1.43801419580102,1.62420032684573e-121,1.41753737123079e-119,"down","yes","MAD2L1","protein_coding","chr4:120055608-120067074:-","gi|297674241|ref|XP_002815141.1|",1446,0,"PREDICTED: mitotic spindle assembly checkpoint protein MAD2A [Pongo abelii]","gi|16041586|gb|AC097173.1|",4683,0,"Homo sapiens BAC clone RP11-96A1 from 4, complete sequence","Q13257",418,6e-133,"Mitotic spindle assembly checkpoint protein MAD2A",".",".",".",".","pfam02301","HORMA","HORMA domain. The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognize chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0051301|cell division;GO:0007093|mitotic cell cycle checkpoint;GO:0000070|mitotic sister chromatid segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:0043066|negative regulation of apoptotic process;GO:0045930|negative regulation of mitotic cell cycle;GO:0042177|negative regulation of protein catabolic process;GO:1904667|negative regulation of ubiquitin protein ligase activity;GO:0090267|positive regulation of mitotic cell cycle spindle assembly checkpoint;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0072686|mitotic spindle;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0000922|spindle pole;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K02537","MAD2; mitotic spindle assembly checkpoint protein MAD2"]
["ENSG00000167513",402,437,375,809.71094228444,1002,1289,1656,0.368188095527318,-1.44148511350467,8.3660474773663e-74,3.66737099416912e-72,"down","yes","CDT1","protein_coding","chr16:88803213-88809258:+","gi|188497689|ref|NP_112190.2|",2093,0,"DNA replication factor Cdt1 [Homo sapiens]","gi|188497688|ref|NM_030928.3|",2675,0,"Homo sapiens chromatin licensing and DNA replication factor 1 (CDT1), mRNA","Q9H211",810,0,"DNA replication factor Cdt1",".",".",".",".","pfam08839","CDT1","DNA replication factor CDT1 like. CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.","GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051301|cell division;GO:0007059|chromosome segregation;GO:1902426|negative regulation of mitotic spindle assembly checkpoint;GO:0000076|DNA replication checkpoint;GO:0071163|DNA replication preinitiation complex assembly;GO:0000082|G1/S transition of mitotic cell cycle;GO:0051383|kinetochore organization;GO:0000278|mitotic cell cycle;GO:0035563|positive regulation of chromatin binding;GO:0045740|positive regulation of DNA replication;GO:2000105|positive regulation of DNA-dependent DNA replication;GO:2001178|positive regulation of mediator complex assembly;GO:0031334|positive regulation of protein complex assembly;GO:0033044|regulation of chromosome organization;GO:1902595|regulation of DNA replication origin binding;GO:0030174|regulation of DNA-dependent DNA replication initiation;GO:0033262|regulation of nuclear cell cycle DNA replication;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0072708|response to sorbitol;","GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003677|DNA binding;","K10727","CDT1; chromatin licensing and DNA replication factor 1"]
["ENSG00000117650",461,405,416,855.596335415867,1123,1353,1667,0.368053161690537,-1.44201393032237,3.66894734698132e-87,2.01614405779418e-85,"down","yes","NEK2","protein_coding","chr1:211658657-211675630:-","gi|4505373|ref|NP_002488.1|",2171,0,"serine/threonine-protein kinase Nek2 isoform 1 [Homo sapiens]","gi|323510686|ref|NM_002497.3|",2131,0,"Homo sapiens NIMA related kinase 2 (NEK2), transcript variant 1, mRNA","P51955",840,0,"Serine/threonine-protein kinase Nek2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001824|blastocyst development;GO:0051301|cell division;GO:0051299|centrosome separation;GO:0007059|chromosome segregation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0051321|meiotic cell cycle;GO:0000278|mitotic cell cycle;GO:0000070|mitotic sister chromatid segregation;GO:0090307|mitotic spindle assembly;GO:1903126|negative regulation of centriole-centriole cohesion;GO:0043392|negative regulation of DNA binding;GO:0051973|positive regulation of telomerase activity;GO:1904355|positive regulation of telomere capping;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0051988|regulation of attachment of spindle microtubules to kinetochore;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0046602|regulation of mitotic centrosome separation;GO:0007088|regulation of mitotic nuclear division;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0000777|condensed chromosome kinetochore;GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0005874|microtubule;GO:0030496|midbody;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;GO:0000922|spindle pole;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0019903|protein phosphatase binding;GO:0004674|protein serine/threonine kinase activity;",".","."]
["ENSG00000225556",4,6,7,11.46535924057,16,18,21,0.367553698174344,-1.44397305737233,0.0166991465633646,0.0420761775198139,"down","yes","C2CD4D","protein_coding","chr1:151837819-151840557:-","gi|426331487|ref|XP_004026712.1|",1248,7e-165,"PREDICTED: C2 calcium-dependent domain-containing protein 4D [Gorilla gorilla gorilla]","gi|767908076|ref|XM_011509056.1|",1757,0,"PREDICTED: Homo sapiens C2 calcium-dependent domain containing 4D (C2CD4D), transcript variant X2, mRNA","B7Z1M9",484,5e-166,"C2 calcium-dependent domain-containing protein 4D",".",".",".",".","pfam00168","C2","C2 domain.",".","GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;",".","."]
["ENSG00000156509",88,80,65,155.733484671027,198,251,309,0.365917764021884,-1.45040863973457,1.79513660943782e-18,1.98763461095503e-17,"down","yes","FBXO43","protein_coding","chr8:100133360-100145800:-","gi|117606351|ref|NP_001025031.2|",3323,0,"F-box only protein 43 [Homo sapiens]","gi|302370919|ref|NR_036491.1|",3082,0,"Homo sapiens F-box protein 43 (FBXO43), transcript variant 1, non-coding RNA","Q4G163",1284,0,"F-box only protein 43",".",".",".",".","pfam01485","IBR","IBR domain. The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.","GO:0051321|meiotic cell cycle;GO:0045835|negative regulation of meiotic nuclear division;GO:0016567|protein ubiquitination;GO:0007088|regulation of mitotic nuclear division;","GO:0005634|nucleus;","GO:0046872|metal ion binding;","K10318","FBXO43, EMI2; F-box protein 43"]
["ENSG00000183186",34,27,35,64.4781017035399,87,100,125,0.36581167930034,-1.45082695801916,1.48515404401644e-08,8.64382957181324e-08,"down","yes","C2CD4C","protein_coding","chr19:405438-409170:-","gi|119581604|gb|EAW61200.1|",2080,0,"hCG1659953, isoform CRA_c, partial [Homo sapiens]","gi|210147452|ref|NM_001136263.1|",3124,0,"Homo sapiens C2 calcium-dependent domain containing 4C (C2CD4C), mRNA","Q8TF44",734,0,"C2 calcium-dependent domain-containing protein 4C",".",".",".",".","pfam00168","C2","C2 domain.",".","GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;",".","."]
["ENSG00000178343",328,353,279,643.307236161688,813,1059,1256,0.365644527131228,-1.45148632657063,6.03352172476822e-62,2.171167295286e-60,"down","yes","SHISA3","protein_coding","chr4:42397839-42402487:+","gi|122937450|ref|NP_001073974.1|",995,1e-127,"protein shisa-3 homolog precursor [Homo sapiens]","gi|122937449|ref|NM_001080505.1|",1971,0,"Homo sapiens shisa family member 3 (SHISA3), mRNA","A0PJX4",387,3e-129,"Protein shisa-3 homolog",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0007275|multicellular organismal development;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000119333",929,926,863,1826.29166503724,2526,2804,3489,0.365282495259475,-1.45291547507037,3.51651994062154e-139,3.6270928670967e-137,"down","yes","WDR34","protein_coding","chr9:128633661-128656787:-","gi|66267730|ref|NP_443076.2|",2552,0,"WD repeat-containing protein 34 [Homo sapiens]","gi|66267729|ref|NM_052844.3|",1755,0,"Homo sapiens WD repeat domain 34 (WDR34), mRNA","Q96EX3",961,0,"WD repeat-containing protein 34",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0060271|cilium morphogenesis;GO:0042073|intraciliary transport;GO:0035735|intraciliary transport involved in cilium morphogenesis;","GO:0005930|axoneme;GO:0005814|centriole;GO:0036064|ciliary basal body;GO:0097014|ciliary cytoplasm;GO:0097542|ciliary tip;GO:0005929|cilium;GO:0005868|cytoplasmic dynein complex;GO:0005829|cytosol;","GO:0045504|dynein heavy chain binding;GO:0045503|dynein light chain binding;",".","."]
["ENSG00000138160",1164,1082,1099,2248.76429193588,3000,3594,4292,0.36489731777576,-1.45443754863976,1.78303382379761e-187,2.89001314230322e-185,"down","yes","KIF11","protein_coding","chr10:92593286-92655395:+","gi|13699824|ref|NP_004514.2|",5529,0,"kinesin-like protein KIF11 [Homo sapiens]","gi|197304797|ref|NM_004523.3|",4860,0,"Homo sapiens kinesin family member 11 (KIF11), mRNA","P52732",2134,0,"Kinesin-like protein KIF11","SPAC25G10.07c",374,6e-108,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0007018|microtubule-based movement;GO:0000278|mitotic cell cycle;GO:0007100|mitotic centrosome separation;GO:0090307|mitotic spindle assembly;GO:0007052|mitotic spindle organization;GO:0046602|regulation of mitotic centrosome separation;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:0007051|spindle organization;","GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0016020|membrane;GO:0005874|microtubule;GO:0072686|mitotic spindle;GO:0005819|spindle;GO:0000922|spindle pole;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0019901|protein kinase binding;GO:0044877|macromolecular complex binding;","K10398","KIF11, EG5; kinesin family member 11"]
["ENSG00000273891",10,2,9,14.0757669869397,13,32,24,0.363666279699252,-1.45931293419144,0.0131730190611554,0.034132347078394,"down","yes","AL731566.1","antisense","chr10:121965764-121967700:+","gi|355563670|gb|EHH20232.1|",186,1e-22,"hypothetical protein EGK_03041, partial [Macaca mulatta]","gi|666670761|tpe|LK938923.1|",1937,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473358.1 (RP11-500G22.5 gene), antisense","Q96CB5",66.6,3e-11,"Putative uncharacterized protein C8orf44",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005654|nucleoplasm;",".",".","."]
["ENSG00000123219",225,246,220,466.081113966781,617,758,883,0.363625718085411,-1.45947385453534,6.14872307013095e-49,1.7415061758691e-47,"down","yes","CENPK","protein_coding","chr5:65517766-65563171:-","gi|16905073|ref|NP_071428.2|",1393,0,"centromere protein K [Homo sapiens]","gi|388452922|ref|NM_022145.4|",1731,0,"Homo sapiens centromere protein K (CENPK), transcript variant 1, mRNA","Q9BS16",541,0,"Centromere protein K",".",".",".",".","pfam11802","CENP-K","Centromere-associated protein K. CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.","GO:0034080|CENP-A containing nucleosome assembly;GO:0051382|kinetochore assembly;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005654|nucleoplasm;",".","K11503","CENPK; centromere protein K"]
["ENSG00000105974",2343,2330,2343,4730.82335338244,5920,7671,9505,0.363514907103659,-1.45991356715639,8.05571369188958e-251,2.07171474252222e-248,"down","yes","CAV1","protein_coding","chr7:116524785-116561184:+","gi|635115788|ref|XP_007980866.1|",1376,1e-178,"PREDICTED: caveolin-1 isoform X1 [Chlorocebus sabaeus]","gi|290542358|ref|NM_001172895.1|",3201,0,"Homo sapiens caveolin 1 (CAV1), transcript variant 2, mRNA","Q2QLF2",351,5e-112,"Caveolin-1",".",".",".",".","pfam01146","Caveolin","Caveolin. All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.","GO:0001525|angiogenesis;GO:0086098|angiotensin-activated signaling pathway involved in heart process;GO:0097190|apoptotic signaling pathway;GO:0006816|calcium ion transport;GO:0070836|caveola assembly;GO:0072584|caveolin-mediated endocytosis;GO:0071360|cellular response to exogenous dsRNA;GO:0071455|cellular response to hyperoxia;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0042632|cholesterol homeostasis;GO:0000188|inactivation of MAPK activity;GO:0007595|lactation;GO:0019915|lipid storage;GO:0060056|mammary gland involution;GO:0051899|membrane depolarization;GO:2000811|negative regulation of anoikis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0001960|negative regulation of cytokine-mediated signaling pathway;GO:0001937|negative regulation of endothelial cell proliferation;GO:0030857|negative regulation of epithelial cell differentiation;GO:1903609|negative regulation of inward rectifier potassium channel activity;GO:0060546|negative regulation of necroptotic process;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0051001|negative regulation of nitric-oxide synthase activity;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:1900085|negative regulation of peptidyl-tyrosine autophosphorylation;GO:0048550|negative regulation of pinocytosis;GO:0032091|negative regulation of protein binding;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0031397|negative regulation of protein ubiquitination;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0033484|nitric oxide homeostasis;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0060355|positive regulation of cell adhesion molecule production;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:1903598|positive regulation of gap junction assembly;GO:0010628|positive regulation of gene expression;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0032092|positive regulation of protein binding;GO:0031398|positive regulation of protein ubiquitination;GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0045907|positive regulation of vasoconstriction;GO:0010608|posttranscriptional regulation of gene expression;GO:0051260|protein homooligomerization;GO:0008104|protein localization;GO:0031623|receptor internalization;GO:2000286|receptor internalization involved in canonical Wnt signaling pathway;GO:0019065|receptor-mediated endocytosis of virus by host cell;GO:0030193|regulation of blood coagulation;GO:1901844|regulation of cell communication by electrical coupling involved in cardiac conduction;GO:2000535|regulation of entry of bacterium into host cell;GO:0019217|regulation of fatty acid metabolic process;GO:0086091|regulation of heart rate by cardiac conduction;GO:0098903|regulation of membrane repolarization during action potential;GO:1900027|regulation of ruffle assembly;GO:0006940|regulation of smooth muscle contraction;GO:0003057|regulation of the force of heart contraction by chemical signal;GO:0098911|regulation of ventricular cardiac muscle cell action potential;GO:0009617|response to bacterium;GO:0051592|response to calcium ion;GO:0043627|response to estrogen;GO:0001666|response to hypoxia;GO:0002931|response to ischemia;GO:0032570|response to progesterone;GO:0007519|skeletal muscle tissue development;GO:0031295|T cell costimulation;GO:0006641|triglyceride metabolic process;GO:0001570|vasculogenesis;GO:0042310|vasoconstriction;","GO:0002080|acrosomal membrane;GO:0005901|caveola;GO:0005938|cell cortex;GO:0005929|cilium;GO:0005768|endosome;GO:0005925|focal adhesion;GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0034098|VCP-NPL4-UFD1 AAA ATPase complex;","GO:0051117|ATPase binding;GO:0042802|identical protein binding;GO:0070320|inward rectifier potassium channel inhibitor activity;GO:0044325|ion channel binding;GO:0050998|nitric-oxide synthase binding;GO:0016504|peptidase activator activity;GO:0030674|protein binding, bridging;GO:0046982|protein heterodimerization activity;GO:0019901|protein kinase binding;GO:0032947|protein complex scaffold;GO:0048365|Rac GTPase binding;GO:0005102|receptor binding;","K06278","CAV1; caveolin 1"]
["ENSG00000175063",1234,1231,1136,2432.74152463113,2991,3931,5003,0.361729401821634,-1.46701722805671,7.24255638434488e-179,1.0582911177367e-176,"down","yes","UBE2C","protein_coding","chr20:45812576-45816957:+","gi|5902146|ref|NP_008950.1|",783,1e-101,"ubiquitin-conjugating enzyme E2 C isoform 1 [Homo sapiens]","gi|694979305|ref|XM_001156993.3|",903,0,"PREDICTED: Pan troglodytes ubiquitin-conjugating enzyme E2C (UBE2C), transcript variant X2, mRNA","O00762",306,4e-103,"Ubiquitin-conjugating enzyme E2 C",".",".",".",".","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0051301|cell division;GO:0010458|exit from mitosis;GO:0010994|free ubiquitin chain polymerization;GO:0031536|positive regulation of exit from mitosis;GO:1904668|positive regulation of ubiquitin protein ligase activity;GO:0070979|protein K11-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0016567|protein ubiquitination;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005680|anaphase-promoting complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0000151|ubiquitin ligase complex;","GO:0005524|ATP binding;GO:0061631|ubiquitin conjugating enzyme activity;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K06688","UBE2C, UBC11; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]"]
["ENSG00000176884",4,8,12,16.4328291495863,21,26,33,0.361683383792754,-1.46720077466652,0.00491204549998803,0.0139946135308374,"down","yes","GRIN1","protein_coding","chr9:137138390-137168762:+","gi|11038637|ref|NP_015566.1|",5076,0,"glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor [Homo sapiens]","gi|297374806|ref|NM_007327.3|",4382,0,"Homo sapiens glutamate ionotropic receptor NMDA type subunit 1 (GRIN1), transcript variant GluN1-1a, mRNA","Q05586",1959,0,"Glutamate receptor ionotropic, NMDA 1",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0008344|adult locomotory behavior;GO:0007420|brain development;GO:0055074|calcium ion homeostasis;GO:0097553|calcium ion transmembrane import into cytosol;GO:0006812|cation transport;GO:0021987|cerebral cortex development;GO:0001661|conditioned taste aversion;GO:0048013|ephrin receptor signaling pathway;GO:0060079|excitatory postsynaptic potential;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0007616|long-term memory;GO:0060179|male mating behavior;GO:0000165|MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0008355|olfactory learning;GO:0021586|pons maturation;GO:0043065|positive regulation of apoptotic process;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:2001056|positive regulation of cysteine-type endopeptidase activity;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0060134|prepulse inhibition;GO:0018964|propylene metabolic process;GO:0051290|protein heterotetramerization;GO:1903539|protein localization to postsynaptic membrane;GO:0050770|regulation of axonogenesis;GO:0048814|regulation of dendrite morphogenesis;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0042391|regulation of membrane potential;GO:0043576|regulation of respiratory gaseous exchange;GO:0051963|regulation of synapse assembly;GO:0048167|regulation of synaptic plasticity;GO:0007585|respiratory gaseous exchange;GO:0001975|response to amphetamine;GO:0045471|response to ethanol;GO:0043278|response to morphine;GO:0019233|sensory perception of pain;GO:0035176|social behavior;GO:0001967|suckling behavior;GO:0035249|synaptic transmission, glutamatergic;GO:0008542|visual learning;","GO:0030054|cell junction;GO:0009986|cell surface;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0005783|endoplasmic reticulum;GO:0060076|excitatory synapse;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0043005|neuron projection;GO:0017146|NMDA selective glutamate receptor complex;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0098839|postsynaptic density membrane;GO:0045211|postsynaptic membrane;GO:0045202|synapse;GO:0043083|synaptic cleft;GO:0097060|synaptic membrane;GO:0008021|synaptic vesicle;GO:0043195|terminal bouton;","GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0005234|extracellular-glutamate-gated ion channel activity;GO:0016595|glutamate binding;GO:0022849|glutamate-gated calcium ion channel activity;GO:0016594|glycine binding;GO:0042165|neurotransmitter binding;GO:0004972|NMDA glutamate receptor activity;GO:0044877|macromolecular complex binding;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0005102|receptor binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05208","GRIN1; glutamate receptor ionotropic, NMDA 1"]
["ENSG00000080986",386,399,358,773.065720191845,1004,1242,1519,0.361605189542717,-1.4675127122841,3.1022324929531e-81,1.53032890854423e-79,"down","yes","NDC80","protein_coding","chr18:2571511-2616635:+","gi|5174457|ref|NP_006092.1|",3268,0,"kinetochore protein NDC80 homolog [Homo sapiens]","gi|215820615|ref|NM_006101.2|",2172,0,"Homo sapiens NDC80 kinetochore complex component (NDC80), mRNA","O14777",1263,0,"Kinetochore protein NDC80 homolog","SPBC11C11.03",161,4e-41,"COG5185","pfam03801","Ndc80_HEC","HEC/Ndc80p family. Members of this family are components of the mitotic spindle. It has been shown that Ndc80/HEC from yeast is part of a complex called the Ndc80p complex. This complex is thought to bind to the microtubules of the spindle.","GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0000132|establishment of mitotic spindle orientation;GO:0051383|kinetochore organization;GO:0051310|metaphase plate congression;GO:0000278|mitotic cell cycle;GO:0000070|mitotic sister chromatid segregation;GO:0007052|mitotic spindle organization;GO:0090267|positive regulation of mitotic cell cycle spindle assembly checkpoint;","GO:0005813|centrosome;GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0000942|condensed nuclear chromosome outer kinetochore;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0016020|membrane;GO:0031262|Ndc80 complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0042802|identical protein binding;GO:0005200|structural constituent of cytoskeleton;","K11547","NDC80, HEC1, TID3; kinetochore protein NDC80"]
["ENSG00000171219",21,28,24,49.5197676994279,59,83,101,0.360595284689977,-1.47154756333858,5.47374706623013e-07,2.74014101773804e-06,"down","yes","CDC42BPG","protein_coding","chr11:64823387-64844569:-","gi|156766068|ref|NP_059995.2|",6865,0,"serine/threonine-protein kinase MRCK gamma [Homo sapiens]","gi|795555485|ref|XM_011720707.1|",5132,0,"PREDICTED: Macaca nemestrina CDC42 binding protein kinase gamma (DMPK-like) (CDC42BPG), transcript variant X4, mRNA","Q6DT37",2649,0,"Serine/threonine-protein kinase MRCK gamma",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0031532|actin cytoskeleton reorganization;GO:0035556|intracellular signal transduction;GO:0006468|protein phosphorylation;","GO:0031252|cell leading edge;GO:0005829|cytosol;GO:0005815|microtubule organizing center;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K16307","CDC42BP; serine/threonine-protein kinase MRCK [EC:2.7.11.1]"]
["ENSG00000156802",1574,1408,1383,2958.50539862089,3828,4913,5661,0.360195816686936,-1.47314666900147,1.28066440264642e-236,2.87226220909815e-234,"down","yes","ATAD2","protein_coding","chr8:123319850-123416350:-","gi|24497618|ref|NP_054828.2|",6585,0,"ATPase family AAA domain-containing protein 2 [Homo sapiens]","gi|167621406|ref|NM_014109.3|",5565,0,"Homo sapiens ATPase family, AAA domain containing 2 (ATAD2), mRNA","Q6PL18",2539,0,"ATPase family AAA domain-containing protein 2","SPAC31G5.19",467,2e-138,"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0006325|chromatin organization;GO:0031936|negative regulation of chromatin silencing;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003682|chromatin binding;GO:0042393|histone binding;",".","."]
["ENSG00000234753",11,9,15,23.7943002684468,26,44,47,0.360090501317382,-1.47356855112992,0.000561721035843729,0.0019140216876586,"down","yes","FOXP4-AS1","antisense","chr6:41494853-41548621:-","gi|426353169|ref|XP_004044070.1|",229,1e-19,"PREDICTED: uncharacterized protein LOC101139810 [Gorilla gorilla gorilla]","gi|701461524|ref|NR_126415.1|",575,0,"Homo sapiens FOXP4 antisense RNA 1 (FOXP4-AS1), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam01924","HypD","Hydrogenase formation hypA family. HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas.",".",".",".",".","."]
["ENSG00000272870",23,16,13,35.0772288731543,43,64,64,0.359820533878254,-1.47465057567142,2.66258918618038e-05,0.000110064338240564,"down","yes","AC097534.2","antisense","chr4:173363780-173370446:-","gi|119625162|gb|EAX04757.1|",376,9e-40,"hCG2041080, partial [Homo sapiens]","gi|551854719|tpe|HG497493.1|",1921,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473142.1 (RP11-798M19.6 gene), antisense","Q86U02",97.8,3e-22,"Putative uncharacterized protein encoded by LINC00596",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000188985",31,24,17,48.5229730985473,58,85,95,0.35975154088921,-1.4749272285515,8.66107858514784e-07,4.24643832613959e-06,"down","yes","DHFRP1","processed_pseudogene","chr18:26170726-26171284:-","gi|229860|pdb|1DHF|A",988,1e-134,"Chain A, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate","gi|310688906|ref|NG_005427.7|",559,0,"Homo sapiens dihydrofolate reductase pseudogene 1 (DHFRP1) on chromosome 18","P00374",385,5e-136,"Dihydrofolate reductase","SPCC1223.08c_2",104,1e-26,"COG0262","pfam00186","DHFR_1","Dihydrofolate reductase.","GO:0031103|axon regeneration;GO:0046452|dihydrofolate metabolic process;GO:0046655|folic acid metabolic process;GO:0017148|negative regulation of translation;GO:0006730|one-carbon metabolic process;GO:0055114|oxidation-reduction process;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:2000121|regulation of removal of superoxide radicals;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0031427|response to methotrexate;GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0046654|tetrahydrofolate biosynthetic process;GO:0046653|tetrahydrofolate metabolic process;","GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0004146|dihydrofolate reductase activity;GO:0008144|drug binding;GO:0033560|folate reductase activity;GO:0005542|folic acid binding;GO:0051870|methotrexate binding;GO:0003729|mRNA binding;GO:0070402|NADPH binding;GO:1990825|sequence-specific mRNA binding;GO:0000900|translation repressor activity, nucleic acid binding;","K00287","folA; dihydrofolate reductase [EC:1.5.1.3]"]
["ENSG00000133119",614,649,581,1253.97009603482,1651,2085,2357,0.359372790948638,-1.47644691210922,5.43863118993548e-111,4.19601273565902e-109,"down","yes","RFC3","protein_coding","chr13:33818049-33966558:+","gi|4506489|ref|NP_002906.1|",1910,0,"replication factor C subunit 3 isoform 1 [Homo sapiens]","gi|108773785|ref|NM_002915.3|",2382,0,"Homo sapiens replication factor C subunit 3 (RFC3), transcript variant 1, mRNA","P40938",740,0,"Replication factor C subunit 3","SPBC83.14c",369,5e-119,"COG0470","pfam08542","Rep_fac_C","Replication factor C C-terminal domain. This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.","GO:0042769|DNA damage response, detection of DNA damage;GO:0006260|DNA replication;GO:0006271|DNA strand elongation involved in DNA replication;GO:0000731|DNA synthesis involved in DNA repair;GO:0070987|error-free translesion synthesis;GO:0042276|error-prone translesion synthesis;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;GO:0046683|response to organophosphorus;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0031390|Ctf18 RFC-like complex;GO:0005663|DNA replication factor C complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003689|DNA clamp loader activity;","K10756","RFC3_5; replication factor C subunit 3/5"]
["ENSG00000205683",46,23,46,78.4021112548456,126,107,142,0.359246806346992,-1.47695276350144,2.25312830582063e-08,1.29224914548523e-07,"down","yes","DPF3","protein_coding","chr14:72619296-72894116:-","gi|526118069|ref|NP_001267473.1|",1789,0,"zinc finger protein DPF3 isoform 4 [Homo sapiens]","gi|526118068|ref|NM_001280544.1|",4520,0,"Homo sapiens double PHD fingers 3 (DPF3), transcript variant 4, mRNA","Q92784",490,3e-158,"Zinc finger protein DPF3",".",".",".",".","pfam14051","Requiem_N","N-terminal domain of DPF2/REQ. This putative domain has been detected on the human DPF2 protein and was subsequently targeted for structure determination by the Joint Center for Structural Genomics (JCSG). Possibly, the C-terminus extends by 30 amino acids and forms a separate domain. DPF2 interacts with estrogen related receptor alpha (Err-alpha), an orphan receptor which acts as a regulator in energy metabolizm. It was also identified as an adaptor molecule that links nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa-B) dimer RelB/p52 and switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling factor.","GO:0006325|chromatin organization;GO:0007399|nervous system development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0071565|nBAF complex;GO:0005654|nucleoplasm;","GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;",".","."]
["ENSG00000198938",26668,28396,24874,54523.8621876616,61348,94271,114251,0.357744071094911,-1.48300023757301,4.72511712987478e-39,1.07474126416303e-37,"down","yes","MT-CO3","protein_coding","chrMT:9207-9990:+","gi|116242004|gb|ABJ89544.1|",999,9e-134,"cytochrome c oxidase subunit III [Homo sapiens]","gi|1001887523|gb|KU761989.1|",784,0,"Homo sapiens haplogroup H63 mitochondrion, complete genome","P00414",385,7e-134,"Cytochrome c oxidase subunit 3","SMc00013",185,2e-55,"COG1845","pfam00510","COX3","Cytochrome c oxidase subunit III.","GO:0019646|aerobic electron transport chain;GO:0008535|respiratory chain complex IV assembly;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0045277|respiratory chain complex IV;","GO:0004129|cytochrome-c oxidase activity;","K02262","COX3; cytochrome c oxidase subunit 3"]
["ENSG00000165072",3,11,11,17.1880128375245,15,29,43,0.357049277319033,-1.48580489671768,0.00553914936679735,0.0156129055950295,"down","yes","MAMDC2","protein_coding","chr9:70043581-70226970:+","gi|223278413|ref|NP_694999.3|",3519,0,"MAM domain-containing protein 2 precursor [Homo sapiens]","gi|223278412|ref|NM_153267.4|",3616,0,"Homo sapiens MAM domain containing 2 (MAMDC2), transcript variant 1, mRNA","Q7Z304",1360,0,"MAM domain-containing protein 2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.",".","GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0016020|membrane;",".",".","."]
["ENSG00000135476",992,894,913,1910.87740921693,2478,3085,3782,0.356830214057553,-1.48669031644108,3.46608220983813e-184,5.39143497285145e-182,"down","yes","ESPL1","protein_coding","chr12:53268299-53293643:+","gi|134276943|ref|NP_036423.4|",10135,0,"separin [Homo sapiens]","gi|1136391|dbj|D79987.1|",6644,0,"Homo sapiens mRNA for KIAA0165 gene, partial cds","Q14674",3907,0,"Separin","YGR098c",152,7e-36,"COG5155","pfam03568","Peptidase_C50","Peptidase family C50.","GO:0006915|apoptotic process;GO:0040001|establishment of mitotic spindle localization;GO:0045143|homologous chromosome segregation;GO:0051307|meiotic chromosome separation;GO:0000212|meiotic spindle organization;GO:0000281|mitotic cytokinesis;GO:0000070|mitotic sister chromatid segregation;GO:0045875|negative regulation of sister chromatid cohesion;GO:0045842|positive regulation of mitotic metaphase/anaphase transition;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0072686|mitotic spindle;GO:0005634|nucleus;","GO:0003824|catalytic activity;GO:0004197|cysteine-type endopeptidase activity;GO:0008234|cysteine-type peptidase activity;","K02365","ESP1; separase [EC:3.4.22.49]"]
["ENSG00000078401",66,41,52,108.153913699824,123,192,219,0.356414051926205,-1.48837387743097,1.01449502725584e-12,8.2285870839826e-12,"down","yes","EDN1","protein_coding","chr6:12290363-12297194:+","gi|154800437|ref|NP_001946.3|",989,6e-127,"endothelin-1 isoform 1 preproprotein [Homo sapiens]","gi|269995985|ref|NM_001955.4|",2033,0,"Homo sapiens endothelin 1 (EDN1), transcript variant 1, mRNA","P05305",385,2e-128,"Endothelin-1",".",".",".",".","pfam00322","Endothelin","Endothelin family.","GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0014824|artery smooth muscle contraction;GO:0007589|body fluid secretion;GO:0001569|patterning of blood vessels;GO:0019722|calcium-mediated signaling;GO:0051216|cartilage development;GO:0007166|cell surface receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0071277|cellular response to calcium ion;GO:0035690|cellular response to drug;GO:0071398|cellular response to fatty acid;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071389|cellular response to mineralocorticoid stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0009953|dorsal/ventral pattern formation;GO:0042045|epithelial fluid transport;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007507|heart development;GO:0001821|histamine secretion;GO:0001701|in utero embryonic development;GO:0048016|inositol phosphate-mediated signaling;GO:0045321|leukocyte activation;GO:0060137|maternal process involved in parturition;GO:0051899|membrane depolarization;GO:0042474|middle ear morphogenesis;GO:0010259|multicellular organismal aging;GO:0030195|negative regulation of blood coagulation;GO:0032269|negative regulation of cellular protein metabolic process;GO:0046888|negative regulation of hormone secretion;GO:0051771|negative regulation of nitric-oxide synthase biosynthetic process;GO:0034392|negative regulation of smooth muscle cell apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0014032|neural crest cell development;GO:0030185|nitric oxide transport;GO:0030072|peptide hormone secretion;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0031583|phospholipase D-activating G-protein coupled receptor signaling pathway;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0045793|positive regulation of cell size;GO:0070101|positive regulation of chemokine-mediated signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0010595|positive regulation of endothelial cell migration;GO:0010460|positive regulation of heart rate;GO:0046887|positive regulation of hormone secretion;GO:0043507|positive regulation of JUN kinase activity;GO:0043406|positive regulation of MAP kinase activity;GO:0045840|positive regulation of mitotic nuclear division;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0042482|positive regulation of odontogenesis;GO:0032308|positive regulation of prostaglandin secretion;GO:0060585|positive regulation of prostaglandin-endoperoxide synthase activity;GO:0010870|positive regulation of receptor biosynthetic process;GO:0035815|positive regulation of renal sodium excretion;GO:0060298|positive regulation of sarcomere organization;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045987|positive regulation of smooth muscle contraction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0035810|positive regulation of urine volume;GO:0001516|prostaglandin biosynthetic process;GO:0042313|protein kinase C deactivation;GO:0007205|protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0010827|regulation of glucose transport;GO:0006885|regulation of pH;GO:0051930|regulation of sensory perception of pain;GO:0003100|regulation of systemic arterial blood pressure by endothelin;GO:0019229|regulation of vasoconstriction;GO:0007585|respiratory gaseous exchange;GO:0014823|response to activity;GO:0043200|response to amino acid;GO:0071548|response to dexamethasone;GO:0044321|response to leptin;GO:0032496|response to lipopolysaccharide;GO:0035994|response to muscle stretch;GO:0035094|response to nicotine;GO:0010193|response to ozone;GO:0034696|response to prostaglandin F;GO:1902074|response to salt;GO:0033574|response to testosterone;GO:0043179|rhythmic excitation;GO:0019233|sensory perception of pain;GO:0042554|superoxide anion generation;GO:0042310|vasoconstriction;GO:0014826|vein smooth muscle contraction;","GO:0045178|basal part of cell;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0048237|rough endoplasmic reticulum lumen;GO:0030133|transport vesicle;GO:0033093|Weibel-Palade body;","GO:0005125|cytokine activity;GO:0031707|endothelin A receptor binding;GO:0031708|endothelin B receptor binding;GO:0005179|hormone activity;","K16366","EDN1; endothelin-1"]
["ENSG00000228716",414,384,379,804.839092628557,1049,1335,1544,0.356233170593235,-1.48910623588105,1.06605296923888e-86,5.82493758376192e-85,"down","yes","DHFR","protein_coding","chr5:80626228-80654983:-","gi|119616265|gb|EAW95859.1|",1160,4e-145,"dihydrofolate reductase, isoform CRA_a [Homo sapiens]","gi|68303806|ref|NM_000791.3|",3915,0,"Homo sapiens dihydrofolate reductase (DHFR), transcript variant 1, mRNA","P00374",387,9e-124,"Dihydrofolate reductase","SPCC1223.08c_2",103,3e-23,"COG0262","pfam00186","DHFR_1","Dihydrofolate reductase.","GO:0031103|axon regeneration;GO:0046452|dihydrofolate metabolic process;GO:0046655|folic acid metabolic process;GO:0017148|negative regulation of translation;GO:0006730|one-carbon metabolic process;GO:0055114|oxidation-reduction process;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:2000121|regulation of removal of superoxide radicals;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0031427|response to methotrexate;GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0046654|tetrahydrofolate biosynthetic process;GO:0046653|tetrahydrofolate metabolic process;","GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0004146|dihydrofolate reductase activity;GO:0008144|drug binding;GO:0033560|folate reductase activity;GO:0005542|folic acid binding;GO:0051870|methotrexate binding;GO:0003729|mRNA binding;GO:0070402|NADPH binding;GO:1990825|sequence-specific mRNA binding;GO:0000900|translation repressor activity, nucleic acid binding;","K00287","folA; dihydrofolate reductase [EC:1.5.1.3]"]
["ENSG00000162062",174,187,171,364.267884859722,487,561,733,0.356003265414085,-1.49003762061956,5.30803700314906e-41,1.27181885362409e-39,"down","yes","TEDC2","protein_coding","chr16:2460080-2464963:+","gi|767987660|ref|XP_011520969.1|",1412,0,"PREDICTED: uncharacterized protein C16orf59 isoform X1 [Homo sapiens]","gi|21752718|dbj|AK093788.1|",2153,0,"Homo sapiens cDNA FLJ36469 fis, clone THYMU2015762",".",".",".",".",".",".",".",".","pfam12316","Dsh_C","Segment polarity protein dishevelled (Dsh) C terminal. This domain family is found in eukaryotes, and is typically between 177 and 207 amino acids in length. The family is found in association with pfam00778, pfam02377, pfam00610, pfam00595. The segment polarity gene dishevelled (dsh) is required for pattern formation of the embryonic segments. It is involved in the determination of body organisation through the Wingless pathway (analogous to the Wnt-1 pathway).",".",".",".",".","."]
["ENSG00000171848",804,802,723,1591.9359778388,2014,2538,3271,0.355910953979584,-1.49041175909268,5.03285386218188e-147,5.54706773107223e-145,"down","yes","RRM2","protein_coding","chr2:10120698-10131419:+","gi|260064013|ref|NP_001159403.1|",2331,0,"ribonucleoside-diphosphate reductase subunit M2 isoform 1 [Homo sapiens]","gi|675786044|ref|XM_003826953.2|",3539,0,"PREDICTED: Pan paniscus ribonucleotide reductase M2 (RRM2), mRNA","P31350",776,0,"Ribonucleoside-diphosphate reductase subunit M2","YJL026w",446,8e-144,"COG0208","pfam00268","Ribonuc_red_sm","Ribonucleotide reductase, small chain.","GO:0009263|deoxyribonucleotide biosynthetic process;GO:0006260|DNA replication;GO:0070317|negative regulation of G0 to G1 transition;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;","GO:0005829|cytosol;GO:0005971|ribonucleoside-diphosphate reductase complex;","GO:0046872|metal ion binding;GO:0004748|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;","K10808","RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"]
["ENSG00000185347",202,213,144,380.895930518218,467,598,817,0.355891305594173,-1.49049140657292,3.29784118090595e-35,6.75969826751476e-34,"down","yes","TEDC1","protein_coding","chr14:105489855-105499575:+","gi|10440532|dbj|BAB15796.1|",522,5e-57,"FLJ00116 protein [Homo sapiens]","gi|10440531|dbj|AK024506.1|",4396,0,"Homo sapiens mRNA for FLJ00116 protein, partial cds",".",".",".",".",".",".",".",".","pfam14971","DUF4510","Domain of unknown function (DUF4510). This family of proteins is found in eukaryotes. Proteins in this family are typically between 242 and 452 amino acids in length. There are two conserved sequence motifs: LEA and WMD.",".",".",".",".","."]
["ENSG00000031691",223,220,189,433.781656262775,635,665,798,0.354918283633265,-1.4944411980664,8.89450968602829e-43,2.21364261708534e-41,"down","yes","CENPQ","protein_coding","chr6:49463378-49493107:+","gi|40068061|ref|NP_060602.2|",1268,2e-169,"centromere protein Q [Homo sapiens]","gi|46255020|ref|NM_018132.3|",1725,0,"Homo sapiens centromere protein Q (CENPQ), mRNA","Q7L2Z9",493,7e-171,"Centromere protein Q",".",".",".",".","pfam13094","CENP-Q","CENP-Q, a CENPA-CAD centromere complex subunit. CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.","GO:0034080|CENP-A containing nucleosome assembly;GO:0051310|metaphase plate congression;","GO:0015629|actin cytoskeleton;GO:0000775|chromosome, centromeric region;GO:0005829|cytosol;GO:0005654|nucleoplasm;",".","K11509","CENPQ; centromere protein Q"]
["ENSG00000151725",414,349,335,752.274830750215,993,1253,1425,0.354635814865192,-1.49558985273077,5.22791093142822e-78,2.47146926581832e-76,"down","yes","CENPU","protein_coding","chr4:184694618-184734133:-","gi|38016935|ref|NP_078905.2|",2027,0,"centromere protein U [Homo sapiens]","gi|255958229|ref|NM_024629.3|",1997,0,"Homo sapiens centromere protein U (CENPU), transcript variant 1, mRNA","Q71F23",787,0,"Centromere protein U",".",".",".",".","pfam13097","CENP-U","CENP-A nucleosome associated complex (NAC) subunit. CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.","GO:0034080|CENP-A containing nucleosome assembly;GO:0043009|chordate embryonic development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K11513","MLF1IP, CENPU; centromere protein U"]
["ENSG00000198056",144,114,98,243.637587433057,330,387,473,0.354233043796842,-1.49722929810449,8.58375788939186e-28,1.42114611305228e-26,"down","yes","PRIM1","protein_coding","chr12:56731596-56752373:-","gi|119617368|gb|EAW96962.1|",1407,0,"hCG2016482, isoform CRA_c, partial [Homo sapiens]","gi|41349493|ref|NM_000946.2|",1438,0,"Homo sapiens primase (DNA) subunit 1 (PRIM1), mRNA","P49642",533,0,"DNA primase small subunit","SPAC6B12.10c",156,7e-77,"COG1467","pfam01896","DNA_primase_S","Eukaryotic and archaeal DNA primase small subunit. DNA primase synthesizes the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. DNA primase is a heterodimer of large and small subunits. This family also includes baculovirus late expression factor 1 or LEF-1 proteins. Baculovirus LEF-1 is a DNA primase enzyme. Bacterial DNA primase adopts a different fold to archaeal and eukaryotic primases.","GO:0006269|DNA replication, synthesis of RNA primer;GO:0000082|G1/S transition of mitotic cell cycle;GO:0032201|telomere maintenance via semi-conservative replication;","GO:0005658|alpha DNA polymerase:primase complex;GO:0016020|membrane;GO:0005654|nucleoplasm;","GO:0003896|DNA primase activity;GO:0046872|metal ion binding;GO:0003697|single-stranded DNA binding;","K02684","PRI1; DNA primase small subunit [EC:2.7.7.-]"]
["ENSG00000075218",680,631,614,1323.29509395015,1802,2053,2611,0.353721593171251,-1.49931380287651,1.63308282115737e-130,1.55167002238834e-128,"down","yes","GTSE1","protein_coding","chr22:46296741-46330810:+","gi|530420136|ref|XP_005261684.1|",3372,0,"PREDICTED: G2 and S phase-expressed protein 1 isoform X1 [Homo sapiens]","gi|768025012|ref|XM_005261627.2|",3112,0,"PREDICTED: Homo sapiens G-2 and S-phase expressed 1 (GTSE1), transcript variant X1, mRNA","Q9NYZ3",1264,0,"G2 and S phase-expressed protein 1",".",".",".",".","pfam15259","GTSE1_N","G-2 and S-phase expressed 1. This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.","GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007017|microtubule-based process;GO:0030335|positive regulation of cell migration;GO:0046827|positive regulation of protein export from nucleus;GO:1900182|positive regulation of protein localization to nucleus;GO:0050821|protein stabilization;GO:1902749|regulation of cell cycle G2/M phase transition;","GO:0005881|cytoplasmic microtubule;GO:0005829|cytosol;GO:0016020|membrane;GO:0005654|nucleoplasm;",".","K10129","GTSE1, B99; G-2 and S-phase expressed protein 1"]
["ENSG00000111445",366,370,347,745.854045578056,972,1215,1468,0.352935287651985,-1.50252441207662,8.600567043575e-83,4.38856447450991e-81,"down","yes","RFC5","protein_coding","chr12:118013588-118033130:+","gi|194306567|ref|NP_853556.2|",1631,0,"replication factor C subunit 5 isoform 2 [Homo sapiens]","gi|332205901|ref|NM_181578.3|",2449,0,"Homo sapiens replication factor C subunit 5 (RFC5), transcript variant 2, mRNA","P40937",631,0,"Replication factor C subunit 5","YNL290w",311,5e-97,"COG0470","pfam08542","Rep_fac_C","Replication factor C C-terminal domain. This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.","GO:0042769|DNA damage response, detection of DNA damage;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0070987|error-free translesion synthesis;GO:0042276|error-prone translesion synthesis;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;GO:0032201|telomere maintenance via semi-conservative replication;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0019985|translesion synthesis;","GO:0031390|Ctf18 RFC-like complex;GO:0005663|DNA replication factor C complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0019899|enzyme binding;","K10756","RFC3_5; replication factor C subunit 3/5"]
["ENSG00000120539",502,485,444,985.847960610038,1324,1590,1904,0.352653355770976,-1.5036773267445,9.59704130653859e-106,6.78050303005554e-104,"down","yes","MASTL","protein_coding","chr10:27154824-27186924:+","gi|172073175|ref|NP_116233.2|",4732,0,"serine/threonine-protein kinase greatwall isoform 2 [Homo sapiens]","gi|1002819396|ref|NM_032844.4|",3623,0,"Homo sapiens microtubule associated serine/threonine kinase like (MASTL), transcript variant 2, mRNA","Q96GX5",1822,0,"Serine/threonine-protein kinase greatwall",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0051301|cell division;GO:0006974|cellular response to DNA damage stimulus;GO:0007147|female meiosis II;GO:0000086|G2/M transition of mitotic cell cycle;GO:0035556|intracellular signal transduction;GO:0000278|mitotic cell cycle;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0018105|peptidyl-serine phosphorylation;GO:1904668|positive regulation of ubiquitin protein ligase activity;GO:0051726|regulation of cell cycle;","GO:0005813|centrosome;GO:0032154|cleavage furrow;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0051721|protein phosphatase 2A binding;GO:0004674|protein serine/threonine kinase activity;","K16309","MASTL, GW; serine/threonine-protein kinase greatwall [EC:2.7.11.1]"]
["ENSG00000142731",300,263,244,556.485368045188,763,879,1077,0.351786756109022,-1.50722692491289,7.51168298726443e-62,2.69303608658655e-60,"down","yes","PLK4","protein_coding","chr4:127880861-127899195:+","gi|121114283|ref|NP_055079.3|",5178,0,"serine/threonine-protein kinase PLK4 isoform 1 [Homo sapiens]","gi|299829199|ref|NM_014264.4|",3841,0,"Homo sapiens polo like kinase 4 (PLK4), transcript variant 1, mRNA","O00444",1999,0,"Serine/threonine-protein kinase PLK4","ECU01g0630",198,4e-53,"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0007099|centriole replication;GO:0098535|de novo centriole assembly;GO:0000086|G2/M transition of mitotic cell cycle;GO:0046601|positive regulation of centriole replication;GO:0006468|protein phosphorylation;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0060707|trophoblast giant cell differentiation;","GO:0005814|centriole;GO:0005813|centrosome;GO:0032154|cleavage furrow;GO:0005829|cytosol;GO:0098536|deuterosome;GO:0005730|nucleolus;GO:0001741|XY body;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0004674|protein serine/threonine kinase activity;","K08863","PLK4; polo-like kinase 4 [EC:2.7.11.21]"]
["ENSG00000183873",29,19,32,55.3323808679022,71,90,111,0.351278427270361,-1.50931311447199,9.69081457428842e-08,5.22863371419035e-07,"down","yes","SCN5A","protein_coding","chr3:38548057-38649673:-","gi|150417967|ref|NP_001092874.1|",9533,0,"sodium channel protein type 5 subunit alpha isoform c [Homo sapiens]","gi|150417966|ref|NM_001099404.1|",8504,0,"Homo sapiens sodium channel, voltage-gated, type V, alpha subunit (SCN5A), transcript variant 3, mRNA","Q14524",3664,0,"Sodium channel protein type 5 subunit alpha",".",".",".",".","pfam11933","DUF3451","Domain of unknown function (DUF3451). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 199 to 238 amino acids in length. This domain is found associated with pfam06512, pfam00520. This domain has a conserved ADD sequence motif.","GO:0086014|atrial cardiac muscle cell action potential;GO:0086016|AV node cell action potential;GO:0086067|AV node cell to bundle of His cell communication;GO:0003360|brainstem development;GO:0086043|bundle of His cell action potential;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0060048|cardiac muscle contraction;GO:0003231|cardiac ventricle development;GO:0071277|cellular response to calcium ion;GO:0021549|cerebellum development;GO:0051899|membrane depolarization;GO:0086010|membrane depolarization during action potential;GO:0098912|membrane depolarization during atrial cardiac muscle cell action potential;GO:0086045|membrane depolarization during AV node cell action potential;GO:0086048|membrane depolarization during bundle of His cell action potential;GO:0086012|membrane depolarization during cardiac muscle cell action potential;GO:0086047|membrane depolarization during Purkinje myocyte cell action potential;GO:0086046|membrane depolarization during SA node cell action potential;GO:0019228|neuronal action potential;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045760|positive regulation of action potential;GO:0050679|positive regulation of epithelial cell proliferation;GO:0010765|positive regulation of sodium ion transport;GO:0060371|regulation of atrial cardiac muscle cell membrane depolarization;GO:0060372|regulation of atrial cardiac muscle cell membrane repolarization;GO:0086004|regulation of cardiac muscle cell contraction;GO:0002027|regulation of heart rate;GO:0086091|regulation of heart rate by cardiac conduction;GO:1902305|regulation of sodium ion transmembrane transport;GO:0060373|regulation of ventricular cardiac muscle cell membrane depolarization;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0086015|SA node cell action potential;GO:0035725|sodium ion transmembrane transport;GO:0006814|sodium ion transport;GO:0021537|telencephalon development;GO:0086005|ventricular cardiac muscle cell action potential;","GO:0005901|caveola;GO:0009986|cell surface;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0014704|intercalated disc;GO:0005622|intracellular;GO:0016328|lateral plasma membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0042383|sarcolemma;GO:0030315|T-tubule;GO:0001518|voltage-gated sodium channel complex;GO:0030018|Z disc;","GO:0030506|ankyrin binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0017134|fibroblast growth factor binding;GO:0044325|ion channel binding;GO:0050998|nitric-oxide synthase binding;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;GO:0097110|scaffold protein binding;GO:0031625|ubiquitin protein ligase binding;GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0086060|voltage-gated sodium channel activity involved in AV node cell action potential;GO:0086061|voltage-gated sodium channel activity involved in bundle of His cell action potential;GO:0086006|voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0086062|voltage-gated sodium channel activity involved in Purkinje myocyte action potential;GO:0086063|voltage-gated sodium channel activity involved in SA node cell action potential;","K04838","SCN5A; voltage-gated sodium channel type V alpha"]
["ENSG00000004777",89,92,79,179.774188856554,243,299,335,0.351276648880451,-1.5093204183102,2.7057281321096e-22,3.57207968597742e-21,"down","yes","ARHGAP33","protein_coding","chr19:35774532-35788822:+","gi|530415643|ref|XP_005258545.1|",4695,0,"PREDICTED: rho GTPase-activating protein 33 isoform X6 [Homo sapiens]","gi|289547506|ref|NM_001172630.1|",4219,0,"Homo sapiens Rho GTPase activating protein 33 (ARHGAP33), transcript variant 2, mRNA","O14559",1813,0,"Rho GTPase-activating protein 33",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0015031|protein transport;GO:0061001|regulation of dendritic spine morphogenesis;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0009636|response to toxic substance;GO:0007264|small GTPase mediated signal transduction;","GO:0015629|actin cytoskeleton;GO:0005938|cell cortex;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0005096|GTPase activator activity;GO:0035091|phosphatidylinositol binding;GO:0019901|protein kinase binding;","K17933","ARHGAP33, SNX26; Rho GTPase-activating protein 33"]
["ENSG00000212724",28,30,19,53.0630507952364,65,99,96,0.351140820185436,-1.50987837535364,1.82923525636472e-07,9.57976910799968e-07,"down","yes","KRTAP2-3","protein_coding","chr17:41059240-41060114:-","gi|12329925|emb|CAC24555.1|",372,3e-41,"keratin associated protein [Homo sapiens]","gi|18873872|gb|AC037482.14|",875,0,"Homo sapiens chromosome 17, clone RP11-619M15, complete sequence","Q9BYU5",148,1e-42,"Keratin-associated protein 2-1",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0031424|keratinization;","GO:0005829|cytosol;GO:0045095|keratin filament;",".",".","."]
["ENSG00000149636",308,311,343,667.896028078871,835,1147,1303,0.349906866977413,-1.51495711691421,5.18180184419311e-63,1.89651980969254e-61,"down","yes","DSN1","protein_coding","chr20:36751791-36773818:-","gi|223890147|ref|NP_001138787.1|",1825,0,"kinetochore-associated protein DSN1 homolog isoform 1 [Homo sapiens]","gi|19683968|gb|BC026011.1|",2203,0,"Homo sapiens DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), mRNA (cDNA clone MGC:32987 IMAGE:4827570), complete cds","Q9H410",707,0,"Kinetochore-associated protein DSN1 homolog",".",".",".",".","pfam08202","MIS13","Mis12-Mtw1 protein family. Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.","GO:0051456|attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation;GO:0051301|cell division;GO:0000070|mitotic sister chromatid segregation;GO:0043312|neutrophil degranulation;","GO:0035578|azurophil granule lumen;GO:0000777|condensed chromosome kinetochore;GO:0000941|condensed nuclear chromosome inner kinetochore;GO:0005829|cytosol;GO:0005576|extracellular region;GO:0001650|fibrillar center;GO:0000444|MIS12/MIND type complex;GO:0016604|nuclear body;GO:0000818|nuclear MIS12/MIND complex;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0000922|spindle pole;",".","K11544","DSN1; kinetochore-associated protein DSN1"]
["ENSG00000172731",372,360,326,732.61753714122,938,1200,1470,0.349673491232194,-1.5159196655016,3.42086224293606e-83,1.75017482604114e-81,"down","yes","LRRC20","protein_coding","chr10:70298970-70382650:-","gi|46397369|ref|NP_997002.1|",951,3e-117,"leucine-rich repeat-containing protein 20 isoform 1 [Homo sapiens]","gi|501354089|ref|NM_207119.2|",3411,0,"Homo sapiens leucine rich repeat containing 20 (LRRC20), transcript variant 1, mRNA",".",".",".",".","SPBC887.09c",65.1,1e-09,"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSG00000185697",610,566,544,1194.17309362805,1650,1924,2258,0.349201205826166,-1.5178695541433,8.04374299848605e-118,6.71635129674454e-116,"down","yes","MYBL1","protein_coding","chr8:66562175-66614247:-","gi|122937231|ref|NP_001073885.1|",3758,0,"myb-related protein A isoform 1 [Homo sapiens]","gi|659928106|ref|NM_001080416.3|",5192,0,"Homo sapiens MYB proto-oncogene like 1 (MYBL1), transcript variant 1, mRNA","P10243",1450,0,"Myb-related protein A","ECU11g1690",154,1e-40,"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0030154|cell differentiation;GO:0007141|male meiosis I;GO:0000278|mitotic cell cycle;GO:0010529|negative regulation of transposition;GO:1990511|piRNA biosynthetic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0007283|spermatogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135|transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09421","MYBL; myb-related protein"]
["ENSG00000111206",795,776,714,1587.2698904033,2069,2551,3198,0.348423549684854,-1.52108595698573,9.84096798893138e-166,1.3000862367843e-163,"down","yes","FOXM1","protein_coding","chr12:2857681-2877155:-","gi|340545543|ref|NP_001230017.1|",3595,0,"forkhead box protein M1 isoform 4 [Homo sapiens]","gi|340545542|ref|NM_001243088.1|",3484,0,"Homo sapiens forkhead box M1 (FOXM1), transcript variant 4, mRNA","Q08050",1370,0,"Forkhead box protein M1","YCR065w",88.2,5e-17,"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0006281|DNA repair;GO:0000086|G2/M transition of mitotic cell cycle;GO:0090344|negative regulation of cell aging;GO:0032873|negative regulation of stress-activated MAPK cascade;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0008284|positive regulation of cell proliferation;GO:2000781|positive regulation of double-strand break repair;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051726|regulation of cell cycle;GO:0071156|regulation of cell cycle arrest;GO:0001558|regulation of cell growth;GO:0042127|regulation of cell proliferation;GO:0046578|regulation of Ras protein signal transduction;GO:2000377|regulation of reactive oxygen species metabolic process;GO:0006366|transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019901|protein kinase binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09406","FOXM; forkhead box protein M"]
["ENSG00000159259",260,223,182,460.699490575009,573,791,910,0.348048015150911,-1.52264174731418,6.43056227319436e-48,1.79237984285221e-46,"down","yes","CHAF1B","protein_coding","chr21:36385378-36419015:+","gi|4885105|ref|NP_005432.1|",2790,0,"chromatin assembly factor 1 subunit B [Homo sapiens]","gi|7768764|dbj|AP001725.1|",2744,0,"Homo sapiens genomic DNA, chromosome 21q, section 69/105","Q13112",1079,0,"Chromatin assembly factor 1 subunit B",".",".",".",".","pfam15512","CAF-1_p60_C","Chromatin assembly factor complex 1 subunit p60, C-terminal. CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.","GO:0007049|cell cycle;GO:0031497|chromatin assembly;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0006335|DNA replication-dependent nucleosome assembly;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0033186|CAF-1 complex;GO:0005737|cytoplasm;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0042393|histone binding;GO:0051082|unfolded protein binding;","K10751","CHAF1B; chromatin assembly factor 1 subunit B"]
["ENSG00000170577",53,75,55,127.833695422324,179,187,262,0.347185459034716,-1.52622156939128,3.01470011131175e-15,2.8378494752065e-14,"down","yes","SIX2","protein_coding","chr2:45005161-45009430:-","gi|530367148|ref|XP_005264157.1|",1145,2e-148,"PREDICTED: homeobox protein SIX2 isoform X1 [Homo sapiens]","gi|767913683|ref|XM_005264100.2|",2169,0,"PREDICTED: Homo sapiens SIX homeobox 2 (SIX2), transcript variant X1, mRNA","Q9NPC8",444,2e-149,"Homeobox protein SIX2",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0009653|anatomical structure morphogenesis;GO:0009948|anterior/posterior axis specification;GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0002062|chondrocyte differentiation;GO:0072137|condensed mesenchymal cell proliferation;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048557|embryonic digestive tract morphogenesis;GO:0001822|kidney development;GO:0072161|mesenchymal cell differentiation involved in kidney development;GO:0072038|mesenchymal stem cell maintenance involved in nephron morphogenesis;GO:0097168|mesenchymal stem cell proliferation;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0007501|mesodermal cell fate specification;GO:0042474|middle ear morphogenesis;GO:0045596|negative regulation of cell differentiation;GO:0072006|nephron development;GO:0072028|nephron morphogenesis;GO:1902732|positive regulation of chondrocyte proliferation;GO:0006606|protein import into nucleus;GO:0090189|regulation of branching involved in ureteric bud morphogenesis;GO:0032330|regulation of chondrocyte differentiation;GO:0030278|regulation of ossification;","GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0044877|macromolecular complex binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K19472","SIX2; homeobox protein SIX2"]
["ENSG00000119969",461,406,371,864.165160950325,1203,1379,1650,0.346073463585989,-1.53084977291777,4.88766386198982e-89,2.78092214070972e-87,"down","yes","HELLS","protein_coding","chr10:94501434-94613905:+","gi|119570417|gb|EAW50032.1|",1664,0,"helicase, lymphoid-specific, isoform CRA_g [Homo sapiens]","gi|10862717|emb|AL138759.20|",4055,0,"Human DNA sequence from clone RP11-119K6 on chromosome 10, complete sequence","Q9NRZ9",564,4e-178,"Lymphoid-specific helicase",".",".",".",".","pfam00271","Helicase_C","Helicase conserved C-terminal domain. The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0046651|lymphocyte proliferation;GO:0010216|maintenance of DNA methylation;GO:0006346|methylation-dependent chromatin silencing;GO:0007275|multicellular organismal development;GO:0031508|pericentric heterochromatin assembly;GO:0006351|transcription, DNA-templated;","GO:0000775|chromosome, centromeric region;GO:0005634|nucleus;GO:0005721|pericentric heterochromatin;","GO:0005524|ATP binding;GO:0004386|helicase activity;","K19001","HELLS, DDM1; ATP-dependent DNA helicase"]
["ENSG00000127824",854,815,768,1702.3111702576,2242,2756,3390,0.345919772923446,-1.53149061374866,8.17701881650438e-182,1.232174522912e-179,"down","yes","TUBA4A","protein_coding","chr2:219249711-219278170:-","gi|795279976|ref|XP_011820023.1|",2644,0,"PREDICTED: tubulin alpha-4A chain isoform X1 [Mandrillus leucophaeus]","gi|514052658|ref|NM_001278552.1|",2499,0,"Homo sapiens tubulin alpha 4a (TUBA4A), transcript variant 2, mRNA","Q5XIF6",884,0,"Tubulin alpha-4A chain","SPBC800.05c",711,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0019901|protein kinase binding;GO:0005200|structural constituent of cytoskeleton;","K07374","TUBA; tubulin alpha"]
["ENSG00000129810",146,127,125,278.571353669086,383,465,515,0.345321567240883,-1.53398765360137,1.30880236848814e-33,2.57331091573896e-32,"down","yes","SGO1","protein_coding","chr3:20160593-20186292:-","gi|60302875|ref|NP_001012409.1|",2352,0,"shugoshin-like 1 isoform 1 [Homo sapiens]","gi|771917011|ref|NM_001199251.2|",2528,0,"Homo sapiens shugoshin-like 1 (S. pombe) (SGOL1), transcript variant 1, mRNA","Q5FBB7",896,0,"Shugoshin 1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0008608|attachment of spindle microtubules to kinetochore;GO:0051301|cell division;GO:0010457|centriole-centriole cohesion;GO:0007059|chromosome segregation;GO:0045132|meiotic chromosome segregation;GO:0071962|mitotic sister chromatid cohesion, centromeric;","GO:0005813|centrosome;GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0005829|cytosol;GO:0000776|kinetochore;GO:0005654|nucleoplasm;GO:0000922|spindle pole;","GO:0019900|kinase binding;","K11580","SGOL1; shugoshin-like 1"]
["ENSG00000176890",92,76,57,156.346737012707,193,225,366,0.345081055733525,-1.53499282004029,4.13546027816938e-17,4.2632152776767e-16,"down","yes","TYMS","protein_coding","chr18:657604-673578:+","gi|848130330|pdb|4UP1|A",1672,0,"Chain A, Crystal Structure Of Native Human Thymidylate Synthase In Active Form","gi|186972144|ref|NM_001071.2|",1583,0,"Homo sapiens thymidylate synthetase (TYMS), mRNA","P04818",647,0,"Thymidylate synthase","ECU01g1430",362,4e-120,"COG0207","pfam00303","Thymidylat_synt","Thymidylate synthase.","GO:0007568|aging;GO:0051216|cartilage development;GO:0007623|circadian rhythm;GO:0048589|developmental growth;GO:0071897|DNA biosynthetic process;GO:0006231|dTMP biosynthetic process;GO:0006235|dTTP biosynthetic process;GO:0046078|dUMP metabolic process;GO:0019088|immortalization of host cell by virus;GO:0060574|intestinal epithelial cell maturation;GO:0097421|liver regeneration;GO:0017148|negative regulation of translation;GO:0015949|nucleobase-containing small molecule interconversion;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0034097|response to cytokine;GO:0045471|response to ethanol;GO:0051593|response to folic acid;GO:0051384|response to glucocorticoid;GO:0046683|response to organophosphorus;GO:0032570|response to progesterone;GO:0033189|response to vitamin A;GO:0035999|tetrahydrofolate interconversion;GO:0019860|uracil metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0048037|cofactor binding;GO:0005542|folic acid binding;GO:0000166|nucleotide binding;GO:0042803|protein homodimerization activity;GO:1990825|sequence-specific mRNA binding;GO:0004799|thymidylate synthase activity;GO:0000900|translation repressor activity, nucleic acid binding;","K00560","thyA, TYMS; thymidylate synthase [EC:2.1.1.45]"]
["ENSG00000152253",245,218,225,481.458609494679,637,755,986,0.344995050208283,-1.5353524318116,5.03010864479512e-57,1.66131396473987e-55,"down","yes","SPC25","protein_coding","chr2:168834132-168913371:-","gi|635058567|ref|XP_007963457.1|",1276,7e-172,"PREDICTED: kinetochore protein Spc25 isoform X1 [Chlorocebus sabaeus]","gi|23510353|ref|NM_020675.3|",1343,0,"Homo sapiens SPC25, NDC80 kinetochore complex component (SPC25), mRNA","Q9HBM1",455,1e-158,"Kinetochore protein Spc25",".",".",".",".","pfam08234","Spindle_Spc25","Chromosome segregation protein Spc25. This is a family of chromosome segregation proteins. It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex, and in vertebrates it forms part of the Ndc80 complex.","GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0007052|mitotic spindle organization;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0031262|Ndc80 complex;GO:0005634|nucleus;",".","K11550","SPBC25, SPC25; kinetochore protein Spc25, animal type"]
["ENSG00000127586",491,447,415,947.423327212724,1327,1471,1851,0.344834882522943,-1.53602237412213,1.869469029865e-97,1.18223995567332e-95,"down","yes","CHTF18","protein_coding","chr16:788046-800737:+","gi|119606114|gb|EAW85708.1|",2499,0,"CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae), isoform CRA_e [Homo sapiens]","gi|10440465|dbj|AK024476.1|",4491,0,"Homo sapiens mRNA for FLJ00069 protein, partial cds","Q8WVB6",963,0,"Chromosome transmission fidelity protein 18 homolog",".",".",".",".","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0007049|cell cycle;GO:0006260|DNA replication;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;","GO:0031390|Ctf18 RFC-like complex;GO:0005829|cytosol;GO:0016020|membrane;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0003677|DNA binding;","K11269","CTF18, CHL12; chromosome transmission fidelity protein 18"]
["ENSG00000019102",8,8,16,22.6462205176124,31,36,44,0.344712565627062,-1.53653420541504,0.000564523413858727,0.00192207018649729,"down","yes","VSIG2","protein_coding","chr11:124747472-124752238:-","gi|767969918|ref|XP_011541029.1|",1240,3e-165,"PREDICTED: V-set and immunoglobulin domain-containing protein 2 isoform X1 [Homo sapiens]","gi|7020562|dbj|AK000460.1|",1188,0,"Homo sapiens cDNA FLJ20453 fis, clone KAT05713","Q96IQ7",451,1e-156,"V-set and immunoglobulin domain-containing protein 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;",".",".","."]
["ENSG00000130675",45,63,77,130.400458012131,157,199,296,0.344586889320001,-1.5370602832631,1.18068467381394e-13,1.013035853582e-12,"down","yes","MNX1","protein_coding","chr7:156994051-157010651:-","gi|296210133|ref|XP_002807092.1|",731,5e-87,"PREDICTED: LOW QUALITY PROTEIN: motor neuron and pancreas homeobox protein 1 [Callithrix jacchus]","gi|89257347|ref|NM_005515.3|",2174,0,"Homo sapiens motor neuron and pancreas homeobox 1 (MNX1), transcript variant 1, mRNA","P50219",286,3e-87,"Motor neuron and pancreas homeobox protein 1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009653|anatomical structure morphogenesis;GO:0031018|endocrine pancreas development;GO:0006959|humoral immune response;GO:0048812|neuron projection morphogenesis;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0021520|spinal cord motor neuron cell fate specification;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K08025","HLXB9, HB9; homeobox protein HB9"]
["ENSG00000251350",4,5,7,11.2325881107176,10,21,26,0.344140419755761,-1.53893074638537,0.0135974030926332,0.0351140327822613,"down","yes","LINC02475","lincRNA","chr4:44016861-44022063:+","gi|119607362|gb|EAW86956.1|",256,3e-22,"hCG1983635 [Homo sapiens]","gi|551852898|tpe|HG496877.1|",2622,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000360659.1 (RP11-328N19.1 gene), lincRNA","O00370",99.8,6e-20,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["ENSG00000149403",9,8,8,17.4803711021433,17,34,37,0.343236614960088,-1.54272463353092,0.00187898758008773,0.00584829957152368,"down","yes","GRIK4","protein_coding","chr11:120511700-120988904:+","gi|29029595|ref|NP_055434.2|",4864,0,"glutamate receptor ionotropic, kainate 4 isoform 1 precursor [Homo sapiens]","gi|732170504|ref|NM_014619.4|",5716,0,"Homo sapiens glutamate ionotropic receptor kainate type subunit 4 (GRIK4), transcript variant 2, mRNA","Q16099",1878,0,"Glutamate receptor ionotropic, kainate 4","glnH",55.1,5e-07,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0007268|synaptic transmission;GO:0007215|glutamate receptor signaling pathway;","GO:0030054|cell junction;GO:0005887|integral component of plasma membrane;GO:0032983|kainate selective glutamate receptor complex;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;GO:0042734|presynaptic membrane;","GO:0005234|extracellular-glutamate-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;","K05204","GRIK4; glutamate receptor, ionotropic kainate 4"]
["ENSG00000213683",17,11,10,26.5852831029722,41,32,58,0.343128176392863,-1.54318049544706,0.000179207156209462,0.000659269049965307,"down","yes","AC002056.1","processed_pseudogene","chr22:50754675-50755434:-","gi|638252533|ref|NP_001279215.1|",368,4e-67,"small nuclear ribonucleoprotein polypeptide A' [Callorhinchus milii]","gi|169646072|ref|NG_001550.3|",760,0,"Homo sapiens small nuclear ribonucleoprotein polypeptide A' pseudogene (LOC150417) on chromosome 22","Q9V4Q8",108,2e-53,"Probable U2 small nuclear ribonucleoprotein A'","SPBC1861.08c",82.4,4e-22,"COG4886","pfam14580","LRR_9","Leucine-rich repeat.","GO:0006325|chromatin organization;GO:0000278|mitotic cell cycle;GO:0000398|mRNA splicing, via spliceosome;GO:0007283|spermatogenesis;","GO:0071013|catalytic step 2 spliceosome;GO:0071011|precatalytic spliceosome;GO:0030532|small nuclear ribonucleoprotein complex;GO:0005686|U2 snRNP;","GO:0030620|U2 snRNA binding;","K11092","SNRPA1; U2 small nuclear ribonucleoprotein A'"]
["ENSG00000145386",606,566,582,1233.97485077172,1626,2029,2433,0.343005232415788,-1.54369751055128,7.17681214003468e-134,6.95609811844165e-132,"down","yes","CCNA2","protein_coding","chr4:121816444-121823933:-","gi|311033358|sp|P20248.2|CCNA2_HUMAN",2156,0,"RecName: Full=Cyclin-A2; Short=Cyclin-A","gi|166197663|ref|NM_001237.3|",2794,0,"Homo sapiens cyclin A2 (CCNA2), mRNA","P20248",835,0,"Cyclin-A2","SPBC582.03",151,6e-38,"COG5024","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0031100|organ regeneration;GO:0044843|cell cycle G1/S phase transition;GO:0051301|cell division;GO:0071314|cellular response to cocaine;GO:0071392|cellular response to estradiol stimulus;GO:0071456|cellular response to hypoxia;GO:1990314|cellular response to insulin-like growth factor stimulus;GO:0044320|cellular response to leptin stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071732|cellular response to nitric oxide;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0090102|cochlea development;GO:0000086|G2/M transition of mitotic cell cycle;GO:0016572|histone phosphorylation;GO:0048146|positive regulation of fibroblast proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0016579|protein deubiquitination;GO:0007265|Ras protein signal transduction;GO:0051726|regulation of cell cycle;GO:0033762|response to glucagon;GO:0016032|viral process;","GO:0097124|cyclin A2-CDK2 complex;GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0001939|female pronucleus;GO:0001940|male pronucleus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;","K06627","CCNA; cyclin A"]
["ENSG00000150893",154,120,109,268.868233762458,378,440,499,0.342883799746323,-1.5442083521121,4.61114974186463e-31,8.47046249724618e-30,"down","yes","FREM2","protein_coding","chr13:38687129-38887131:+","gi|119629013|gb|EAX08608.1|",16309,0,"FRAS1 related extracellular matrix protein 2, isoform CRA_b [Homo sapiens]","gi|614458216|ref|NM_207361.5|",16070,0,"Homo sapiens FRAS1 related extracellular matrix protein 2 (FREM2), mRNA","Q5SZK8",6215,0,"FRAS1-related extracellular matrix protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007155|cell adhesion;GO:0007154|cell communication;GO:0042733|embryonic digit morphogenesis;GO:0001654|eye development;GO:0007507|heart development;GO:0048839|inner ear development;GO:0002009|morphogenesis of an epithelium;","GO:0005604|basement membrane;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;",".","."]
["ENSG00000014138",30,23,15,47.3837497863491,56,75,107,0.342596575061785,-1.54541736601675,5.74461898990911e-07,2.86978013668394e-06,"down","yes","POLA2","protein_coding","chr11:65261762-65305589:+","gi|20127448|ref|NP_002680.2|",2903,0,"DNA polymerase alpha subunit B [Homo sapiens]","gi|744066845|ref|NM_002689.3|",3654,0,"Homo sapiens polymerase (DNA) alpha 2, accessory subunit (POLA2), mRNA","Q14181",1121,0,"DNA polymerase alpha subunit B","SPCC553.09c",180,2e-46,"COG5214","pfam04042","DNA_pol_E_B","DNA polymerase alpha/epsilon subunit B. This family contains a number of DNA polymerase subunits.  The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.","GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000060|protein import into nucleus, translocation;GO:0032201|telomere maintenance via semi-conservative replication;","GO:0005658|alpha DNA polymerase:primase complex;GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0046982|protein heterodimerization activity;","K02321","POLA2; DNA polymerase alpha subunit B"]
["ENSG00000175274",10,10,12,22.6790389297908,30,46,34,0.342160687916551,-1.54725408200869,0.000483225728521571,0.00166585484391851,"down","yes","TP53I11","protein_coding","chr11:44885903-44951306:-","gi|795325589|ref|XP_011818668.1|",819,2e-97,"PREDICTED: tumor protein p53-inducible protein 11 [Colobus angolensis palliatus]","gi|385251373|ref|NM_001258320.1|",3700,0,"Homo sapiens tumor protein p53 inducible protein 11 (TP53I11), transcript variant 1, mRNA","O14683",298,9e-92,"Tumor protein p53-inducible protein 11",".",".",".",".","pfam14936","p53-inducible11","tumor protein p53-inducible protein 11. TP53 is a tumor suppressor gene, when switched on it suppresses tumor development by inducing stable growth arrest or cell apoptosis. The tumor protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumor formation.","GO:0008285|negative regulation of cell proliferation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000100297",979,919,909,1977.02543993903,2510,3291,4000,0.342011908552982,-1.54788153553284,9.56894001914267e-194,1.6479081704395e-191,"down","yes","MCM5","protein_coding","chr22:35400063-35425430:+","gi|578837205|ref|XP_006724305.1|",2151,0,"PREDICTED: DNA replication licensing factor MCM5 isoform X1 [Homo sapiens]","gi|62088803|dbj|AB209612.1|",4595,0,"Homo sapiens mRNA for minichromosome maintenance deficient protein 5 variant protein","P33992",832,0,"DNA replication licensing factor MCM5","YLR274w",504,3e-158,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;","GO:0005829|cytosol;GO:0042555|MCM complex;GO:0016020|membrane;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003688|DNA replication origin binding;GO:0004386|helicase activity;","K02209","MCM5, CDC46; DNA replication licensing factor MCM5 [EC:3.6.4.12]"]
["ENSG00000237649",872,801,812,1751.07094969785,2277,2914,3464,0.341997650580413,-1.54794168061721,5.63260357126115e-181,8.42183392887481e-179,"down","yes","KIFC1","protein_coding","chr6:33391536-33409924:+","gi|966938267|ref|XP_014991595.1|",3342,0,"PREDICTED: kinesin-like protein KIFC1 isoform X1 [Macaca mulatta]","gi|167555109|ref|NM_002263.3|",2706,0,"Homo sapiens kinesin family member C1 (KIFC1), mRNA","Q9BW19",1182,0,"Kinesin-like protein KIFC1","SPAC664.10",311,4e-91,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0051301|cell division;GO:0007018|microtubule-based movement;GO:0007080|mitotic metaphase plate congression;GO:0000070|mitotic sister chromatid segregation;GO:0090307|mitotic spindle assembly;GO:0007283|spermatogenesis;","GO:0005769|early endosome;GO:0005871|kinesin complex;GO:0016020|membrane;GO:0005874|microtubule;GO:0005815|microtubule organizing center;GO:0005634|nucleus;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10405","KIFC1; kinesin family member C1"]
["ENSG00000102384",208,176,170,390.154328451133,545,608,767,0.341979890879453,-1.54801660071606,2.23962235918646e-46,5.99969945333174e-45,"down","yes","CENPI","protein_coding","chrX:101098218-101163681:+","gi|41352697|ref|NP_006724.2|",3941,0,"centromere protein I isoform 1 [Homo sapiens]","gi|768037519|ref|XM_011530895.1|",3046,0,"PREDICTED: Homo sapiens centromere protein I (CENPI), transcript variant X2, mRNA","Q92674",1522,0,"Centromere protein I",".",".",".",".","pfam07778","CENP-I","Mis6. Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.","GO:0034080|CENP-A containing nucleosome assembly;GO:0007548|sex differentiation;","GO:0005829|cytosol;GO:0000776|kinetochore;GO:0016604|nuclear body;GO:0005654|nucleoplasm;",".","K11501","CENPI; centromere protein I"]
["ENSG00000170312",1416,1240,1129,2663.97584528599,3473,4440,5258,0.341625556894584,-1.54951218835432,4.66269295501991e-228,1.02197751950482e-225,"down","yes","CDK1","protein_coding","chr10:60778331-60794852:+","gi|119574589|gb|EAW54204.1|",1579,0,"cell division cycle 2, G1 to S and G2 to M, isoform CRA_a [Homo sapiens]","gi|767964396|ref|XM_005270303.2|",1942,0,"PREDICTED: Homo sapiens cyclin-dependent kinase 1 (CDK1), transcript variant X1, mRNA","P06493",610,0,"Cyclin-dependent kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000187|activation of MAPK activity;GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031100|organ regeneration;GO:0006915|apoptotic process;GO:0007569|cell aging;GO:0051301|cell division;GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0070301|cellular response to hydrogen peroxide;GO:0007098|centrosome cycle;GO:0030261|chromosome condensation;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0030855|epithelial cell differentiation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0090166|Golgi disassembly;GO:0000226|microtubule cytoskeleton organization;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0007077|mitotic nuclear envelope disassembly;GO:0043066|negative regulation of apoptotic process;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0045740|positive regulation of DNA replication;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0010628|positive regulation of gene expression;GO:0033160|positive regulation of protein import into nucleus, translocation;GO:1900182|positive regulation of protein localization to nucleus;GO:0007344|pronuclear fusion;GO:0016579|protein deubiquitination;GO:0034501|protein localization to kinetochore;GO:0006468|protein phosphorylation;GO:0065003|macromolecular complex assembly;GO:0045995|regulation of embryonic development;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0010468|regulation of gene expression;GO:0051445|regulation of meiotic cell cycle;GO:0014038|regulation of Schwann cell differentiation;GO:0014823|response to activity;GO:0014075|response to amine;GO:0048678|response to axon injury;GO:0046686|response to cadmium ion;GO:0046688|response to copper ion;GO:0045471|response to ethanol;GO:0014070|response to organic cyclic compound;GO:0055015|ventricular cardiac muscle cell development;","GO:0005813|centrosome;GO:0097125|cyclin B1-CDK1 complex;GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0030496|midbody;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0072686|mitotic spindle;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005876|spindle microtubule;","GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0030332|cyclin binding;GO:0097472|cyclin-dependent protein kinase activity;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0035173|histone kinase activity;GO:0030544|Hsp70 protein binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0008353|RNA polymerase II carboxy-terminal domain kinase activity;GO:0001618|virus receptor activity;","K02087","CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"]
["ENSG00000203760",184,156,159,351.808842421161,462,524,766,0.340841682776206,-1.55282631608043,6.02089306928722e-40,1.40935662039335e-38,"down","yes","CENPW","protein_coding","chr6:126340174-126348875:+","gi|60302883|ref|NP_001012525.1|",441,4e-52,"centromere protein W isoform b [Homo sapiens]","gi|557357701|ref|NM_001012507.3|",750,0,"Homo sapiens centromere protein W (CENPW), transcript variant 2, mRNA","Q5EE01",174,1e-53,"Centromere protein W",".",".",".",".","pfam15510","CENP-W","Centromere kinetochore component W. CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.","GO:0051301|cell division;GO:0034080|CENP-A containing nucleosome assembly;GO:0051276|chromosome organization;GO:0007059|chromosome segregation;GO:0051382|kinetochore assembly;GO:0000278|mitotic cell cycle;","GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0000776|kinetochore;GO:0016363|nuclear matrix;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;",".","."]
["ENSG00000168077",130,104,87,225.613721914801,271,382,474,0.340568925233831,-1.55398129068793,1.63001522635497e-26,2.57914140163533e-25,"down","yes","SCARA3","protein_coding","chr8:27633868-27676776:+","gi|6230372|dbj|BAA86201.1|",2328,0,"CSR1 [Homo sapiens]","gi|33598923|ref|NM_016240.2|",3510,0,"Homo sapiens scavenger receptor class A member 3 (SCARA3), transcript variant 1, mRNA","Q6AZY7",891,0,"Scavenger receptor class A member 3",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.","GO:0006979|response to oxidative stress;GO:0009650|UV protection;","GO:0005581|collagen trimer;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0005044|scavenger receptor activity;",".","."]
["ENSG00000136982",381,336,274,698.817862493511,902,1138,1431,0.340063216546716,-1.55612513169838,6.24363350649855e-74,2.74947952222247e-72,"down","yes","DSCC1","protein_coding","chr8:119833976-119856010:-","gi|119612400|gb|EAW91994.1|",2223,0,"defective in sister chromatid cohesion homolog 1 (S. cerevisiae), isoform CRA_a [Homo sapiens]","gi|397504098|ref|XM_003822598.1|",2266,0,"PREDICTED: Pan paniscus DNA replication and sister chromatid cohesion 1 (DSCC1), transcript variant X1, mRNA","Q9BVC3",749,0,"Sister chromatid cohesion protein DCC1",".",".",".",".","pfam09724","DUF2036","Uncharacterized conserved protein (DUF2036). This family of proteins includes members ranging in size from approximately 300 to 460 residues. There are a number of well-conserved domains along the length.","GO:0006260|DNA replication;GO:0034088|maintenance of mitotic sister chromatid cohesion;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;GO:0034421|post-translational protein acetylation;GO:0006275|regulation of DNA replication;","GO:0000785|chromatin;GO:0000775|chromosome, centromeric region;GO:0031390|Ctf18 RFC-like complex;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;","K11271","DSCC1, DCC1; sister chromatid cohesion protein DCC1"]
["ENSG00000134690",562,598,514,1184.72560026568,1467,1989,2444,0.339677039302341,-1.55776439331489,2.50338556385566e-111,1.9391687050461e-109,"down","yes","CDCA8","protein_coding","chr1:37692418-37709719:+","gi|686704773|ref|XP_009250614.1|",1666,0,"PREDICTED: borealin [Pongo abelii]","gi|379056368|ref|NM_001256875.1|",2469,0,"Homo sapiens cell division cycle associated 8 (CDCA8), transcript variant 1, mRNA","Q5RBS5",544,0,"Borealin",".",".",".",".","pfam10512","Borealin","Cell division cycle-associated protein 8. The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0032133|chromosome passenger complex;GO:0000775|chromosome, centromeric region;GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0032991|macromolecular complex;GO:0005819|spindle;",".","K11514","CDCA8; Borealin"]
["ENSG00000183150",18,7,11,25.2025229668518,20,57,51,0.339443746674981,-1.558755587037,0.000564369998346825,0.00192188709889011,"down","yes","GPR19","protein_coding","chr12:12660891-12696207:-","gi|767971832|ref|XP_011518924.1|",2171,0,"PREDICTED: probable G-protein coupled receptor 19 isoform X2 [Homo sapiens]","gi|22760361|dbj|AK074729.1|",1748,0,"Homo sapiens cDNA FLJ90248 fis, clone NT2RM2001939, highly similar to Probable G-protein coupled receptor 19","Q15760",823,0,"Probable G-protein coupled receptor 19",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007268|synaptic transmission;GO:0007631|feeding behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G-protein coupled receptor activity;","K04316","GPR19; G protein-coupled receptor 19"]
["ENSG00000148483",9,5,4,12.6454341520262,17,19,27,0.338946043377218,-1.56087246502919,0.00728292134759151,0.0199876190882677,"down","yes","TMEM236","protein_coding","chr10:17752252-17800868:+","gi|150378481|ref|NP_001092314.1|",1600,0,"transmembrane protein 236 [Homo sapiens]","gi|442565701|ref|NM_001098844.2|",5454,0,"Homo sapiens transmembrane protein 236 (TMEM236), mRNA","Q5W0B7",620,0,"Transmembrane protein 236",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000231607",77,90,83,177.587816338693,240,255,389,0.338939803975056,-1.56089902275891,2.33578311426612e-21,2.95233189436205e-20,"down","yes","DLEU2","antisense","chr13:49982552-50125720:-","gi|332841322|ref|XP_001150529.2|",837,3e-101,"PREDICTED: uncharacterized protein LOC745092 isoform X2 [Pan troglodytes]","gi|39777539|gb|AY455757.1|",3068,0,"Homo sapiens candidate tumor suppressor (DLEU2) RNA, antisense sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000094804",762,739,702,1563.16227036535,1965,2550,3280,0.338422833295935,-1.56310118490612,8.84473867976877e-153,1.07293911732943e-150,"down","yes","CDC6","protein_coding","chr17:40287633-40304657:+","gi|4502703|ref|NP_001245.1|",2887,0,"cell division control protein 6 homolog [Homo sapiens]","gi|426348372|ref|XM_004041763.1|",3224,0,"PREDICTED: Gorilla gorilla gorilla cell division cycle 6 homolog (S. cerevisiae) (CDC6), mRNA","Q99741",1116,0,"Cell division control protein 6 homolog","SPBC14C8.07c",214,2e-57,"COG1474","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0051301|cell division;GO:1904385|cellular response to angiotensin;GO:1904117|cellular response to vasopressin;GO:0006260|DNA replication;GO:0000076|DNA replication checkpoint;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0008285|negative regulation of cell proliferation;GO:0008156|negative regulation of DNA replication;GO:0051984|positive regulation of chromosome segregation;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0032467|positive regulation of cytokinesis;GO:0048146|positive regulation of fibroblast proliferation;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0007089|traversing start control point of mitotic cell cycle;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0051233|spindle midzone;GO:0000922|spindle pole;","GO:0005524|ATP binding;GO:0019900|kinase binding;GO:0000166|nucleotide binding;","K02213","CDC6; cell division control protein 6"]
["ENSG00000188015",14,12,16,29.9083402613651,41,46,61,0.338370259303682,-1.563325325013,3.37562238645664e-05,0.000137534863941647,"down","yes","S100A3","protein_coding","chr1:153547329-153549372:-","gi|119573694|gb|EAW53309.1|",473,9e-56,"S100 calcium binding protein A3, isoform CRA_c [Homo sapiens]","gi|4506762|ref|NM_002960.1|",738,0,"Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA","P33764",175,3e-53,"Protein S100-A3",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.",".","GO:0005829|cytosol;GO:0005730|nucleolus;","GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;",".","."]
["ENSG00000224126",5,5,5,10.7201609527276,15,21,16,0.337874830703933,-1.56543921100614,0.0131780749297837,0.0341408608792033,"down","yes","UBE2SP2","processed_pseudogene","chr17:18677261-18677757:+","gi|332256558|ref|XP_003277383.1|",577,5e-72,"PREDICTED: ubiquitin-conjugating enzyme E2 S [Nomascus leucogenys]","gi|953267116|ref|NG_031882.2|",497,0,"Homo sapiens ubiquitin conjugating enzyme E2S pseudogene 2 (UBE2SP2) on chromosome 17","Q16763",225,5e-73,"Ubiquitin-conjugating enzyme E2 S","YDR092w",86.7,1e-20,"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0051301|cell division;GO:0006464|cellular protein modification process;GO:0010458|exit from mitosis;GO:0010994|free ubiquitin chain polymerization;GO:1904668|positive regulation of ubiquitin protein ligase activity;GO:0070979|protein K11-linked ubiquitination;GO:0044314|protein K27-linked ubiquitination;GO:0035519|protein K29-linked ubiquitination;GO:0085020|protein K6-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0016567|protein ubiquitination;","GO:0005680|anaphase-promoting complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0061631|ubiquitin conjugating enzyme activity;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K10583","UBE2S, E2EPF; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]"]
["ENSG00000236914",7,6,6,13.5072303005849,17,24,26,0.33742535776355,-1.56735969759547,0.00482532442351312,0.01377806920514,"down","yes","LINC01852","lincRNA","chr15:38069481-38072959:-","gi|655864749|ref|XP_008267804.1|",143,3e-07,"PREDICTED: protein transport protein SEC31-like [Oryctolagus cuniculus]","gi|551879173|tpe|HG506878.1|",967,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000418183.1 (RP11-1008C21.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam09356","Phage_BR0599","Phage conserved hypothetical protein BR0599. This entry describes a family of proteins found almost exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. An apparent exception is Wolbachia pipientis wMel, a bacterial endosymbiont of the fruit fly, which has several candidate phage-related genes physically separate from obvious prophage regions.",".",".",".",".","."]
["ENSG00000148773",4170,3965,3696,8421.68075072333,10774,13961,17182,0.337052312954462,-1.56895556940663,0,0,"down","yes","MKI67","protein_coding","chr10:128096659-128126385:-","gi|103472005|ref|NP_002408.3|",16481,0,"antigen KI-67 isoform 1 [Homo sapiens]","gi|225543213|ref|NM_002417.4|",12497,0,"Homo sapiens marker of proliferation Ki-67 (MKI67), transcript variant 1, mRNA","P46013",6353,0,"Proliferation marker protein Ki-67",".",".",".",".","pfam08065","K167R","K167R (NUC007) repeat. This family represents the K167/Chmadrin repeat. The function of this repeat is unknown.","GO:0007049|cell cycle;GO:0008283|cell proliferation;GO:1902275|regulation of chromatin organization;GO:0051983|regulation of chromosome segregation;GO:0007088|regulation of mitotic nuclear division;","GO:0005694|chromosome;GO:0016020|membrane;GO:0016604|nuclear body;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0008022|protein C-terminus binding;GO:0003723|RNA binding;","K17582","MKI67; antigen KI-67"]
["ENSG00000256673",17,6,14,26.3558008488585,37,47,45,0.336798150415139,-1.57004387926878,0.000186135425352955,0.000683323198364635,"down","yes","AC141557.1","unprocessed_pseudogene","chr12:9398355-9414851:-","gi|767972523|ref|XP_011519192.1|",313,4e-49,"PREDICTED: ovostatin homolog 2 isoform X2 [Homo sapiens]","gi|528319760|gb|AC254631.1|",132,4e-61,"Homo sapiens BAC clone CH17-138H12 from chromosome 12, complete sequence","Q6IE36",117,2e-44,"Ovostatin homolog 2",".",".",".",".","pfam07677","A2M_recep","A-macroglobulin receptor. This family includes the receptor domain region of the alpha-2-macroglobulin family.",".","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSG00000144554",240,209,190,454.4705433317,597,724,941,0.336712453642567,-1.5704110132344,1.07947814040009e-55,3.51705648176299e-54,"down","yes","FANCD2","protein_coding","chr3:10026414-10101930:+","gi|21361861|ref|NP_149075.2|",7597,0,"Fanconi anemia group D2 protein isoform a [Homo sapiens]","gi|987437909|ref|NM_033084.4|",5219,0,"Homo sapiens Fanconi anemia complementation group D2 (FANCD2), transcript variant 1, mRNA","Q9BXW9",2837,0,"Fanconi anemia group D2 protein",".",".",".",".","pfam14631","FancD2","Fanconi anaemia protein FancD2 nuclease. The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.","GO:0048854|brain morphogenesis;GO:0034599|cellular response to oxidative stress;GO:0006281|DNA repair;GO:0007276|gamete generation;GO:0036297|interstrand cross-link repair;GO:0097150|neuronal stem cell population maintenance;GO:2000348|regulation of CD40 signaling pathway;GO:0051090|regulation of sequence-specific DNA binding transcription factor activity;GO:0050727|regulation of inflammatory response;GO:0045589|regulation of regulatory T cell differentiation;GO:0010332|response to gamma radiation;GO:0007129|synapsis;","GO:0000793|condensed chromosome;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0070182|DNA polymerase binding;","K10891","FANCD2; fanconi anemia group D2 protein"]
["ENSG00000100479",400,367,362,805.778052869607,1096,1366,1512,0.336526327614798,-1.57120871862975,9.65605677096577e-89,5.46176020523131e-87,"down","yes","POLE2","protein_coding","chr14:49643555-49688422:-","gi|28193232|emb|CAD62358.1|",2620,0,"unnamed protein product [Homo sapiens]","gi|309747078|ref|NM_001197330.1|",1750,0,"Homo sapiens polymerase (DNA) epsilon 2, accessory subunit (POLE2), transcript variant 2, mRNA","P56282",991,0,"DNA polymerase epsilon subunit 2",".",".",".",".","pfam04042","DNA_pol_E_B","DNA polymerase alpha/epsilon subunit B. This family contains a number of DNA polymerase subunits.  The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.","GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0006261|DNA-dependent DNA replication;GO:0042276|error-prone translesion synthesis;GO:0000082|G1/S transition of mitotic cell cycle;","GO:0008622|epsilon DNA polymerase complex;GO:0043231|intracellular membrane-bounded organelle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;","K02325","POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"]
["ENSG00000112029",378,388,341,789.88468542551,1057,1307,1547,0.336446860363422,-1.5715494365426,3.77300997847028e-92,2.22549897445672e-90,"down","yes","FBXO5","protein_coding","chr6:152970519-152983579:-","gi|215982802|ref|NP_001135994.1|",688,3e-78,"F-box only protein 5 isoform b [Homo sapiens]","gi|6690152|gb|AF090885.1|AF090885",2570,0,"Homo sapiens clone HQ0058","Q9UKT4",268,9e-79,"F-box only protein 5",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0051301|cell division;GO:0046785|microtubule polymerization;GO:0045835|negative regulation of meiotic nuclear division;GO:0001556|oocyte maturation;GO:0007346|regulation of mitotic cell cycle;GO:0007088|regulation of mitotic nuclear division;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0007057|spindle assembly involved in female meiosis I;GO:0016050|vesicle organization;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005819|spindle;","GO:0046872|metal ion binding;GO:0019901|protein kinase binding;","K10292","FBXO5, EMI1; F-box protein 5"]
["ENSG00000189184",15,23,16,38.6985305695728,55,64,71,0.336296282858218,-1.57219526229599,3.14744477321837e-06,1.45164789062257e-05,"down","yes","PCDH18","protein_coding","chr4:137518918-137532494:-","gi|14589929|ref|NP_061908.1|",5878,0,"protocadherin-18 isoform 1 precursor [Homo sapiens]","gi|664806061|ref|NM_019035.4|",5906,0,"Homo sapiens protocadherin 18 (PCDH18), transcript variant 1, mRNA","Q9HCL0",2269,0,"Protocadherin-18",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007420|brain development;GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399|nervous system development;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16499","PCDHD2; protocadherin delta 2"]
["ENSG00000177084",1025,973,836,2022.50520525898,2632,3495,3901,0.335623547443016,-1.57508415566653,3.5754398454554e-171,5.03380173278422e-169,"down","yes","POLE","protein_coding","chr12:132623753-132687365:-","gi|30039661|gb|AAP12650.1|",6181,0,"polymerase (DNA directed), epsilon [Homo sapiens]","gi|219521574|gb|BC144561.1|",8008,0,"Homo sapiens cDNA clone IMAGE:9053089","Q07864",2383,0,"DNA polymerase epsilon catalytic subunit A","SPBC25H2.13c",1054,0,"COG0417","pfam08490","DUF1744","Domain of unknown function (DUF1744). This domain is found on the epsilon catalytic subunit of DNA polymerase. It is found C terminal to pfam03104 and pfam00136.","GO:0006287|base-excision repair, gap-filling;GO:0006260|DNA replication;GO:0045004|DNA replication proofreading;GO:0000731|DNA synthesis involved in DNA repair;GO:0048568|embryonic organ development;GO:0000082|G1/S transition of mitotic cell cycle;GO:0006272|leading strand elongation;GO:0006297|nucleotide-excision repair, DNA gap filling;","GO:0008622|epsilon DNA polymerase complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0000166|nucleotide binding;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0008270|zinc ion binding;","K02324","POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"]
["ENSG00000242147",11,9,12,22.843011609211,27,37,51,0.335502132364521,-1.57560615903733,0.000266021820944289,0.000956389353657679,"down","yes","AL365356.5","lincRNA","chr10:5594991-5596118:-","gi|119606848|gb|EAW86442.1|",253,7e-25,"hCG2041508, partial [Homo sapiens]","gi|968121937|ref|NR_134491.1|",697,0,"Homo sapiens uncharacterized LOC105376382 (LOC105376382), long non-coding RNA",".",".",".",".",".",".",".",".","pfam04159","NB","NB glycoprotein. The NB glycoprotein is found in Influenza type B virus. Its function is unknown.",".",".",".",".","."]
["ENSG00000138346",251,204,185,457.163031957672,623,756,884,0.334879655325931,-1.57828536307069,7.10088186084857e-54,2.22702128995199e-52,"down","yes","DNA2","protein_coding","chr10:68414064-68472121:-","gi|578819047|ref|XP_006717743.1|",5651,0,"PREDICTED: DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 [Homo sapiens]","gi|320461727|ref|NM_001080449.2|",4208,0,"Homo sapiens DNA replication helicase/nuclease 2 (DNA2), transcript variant 1, mRNA","P51530",2172,0,"DNA replication ATP-dependent helicase/nuclease DNA2","SPBC16D10.04c",479,2e-143,"COG1112","pfam08696","Dna2","DNA replication factor Dna2. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, ( 5'-flap endonuclease) and helicase activities. It is required for Okazaki fragment processing and is involved in DNA repair pathways.","GO:0006284|base-excision repair;GO:0000729|DNA double-strand break processing;GO:0006260|DNA replication;GO:0000076|DNA replication checkpoint;GO:0033567|DNA replication, Okazaki fragment processing;GO:0043137|DNA replication, removal of RNA primer;GO:0044806|G-quadruplex DNA unwinding;GO:0043504|mitochondrial DNA repair;GO:0006264|mitochondrial DNA replication;GO:1902990|mitotic telomere maintenance via semi-conservative replication;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0045740|positive regulation of DNA replication;GO:0090656|t-circle formation;GO:0000723|telomere maintenance;GO:0032201|telomere maintenance via semi-conservative replication;","GO:0042645|mitochondrial nucleoid;GO:0005739|mitochondrion;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0043139|5'-3' DNA helicase activity;GO:0017108|5'-flap endonuclease activity;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003677|DNA binding;GO:0003678|DNA helicase activity;GO:0004386|helicase activity;GO:0046872|metal ion binding;GO:0004518|nuclease activity;GO:0043142|single-stranded DNA-dependent ATPase activity;GO:0016890|site-specific endodeoxyribonuclease activity, specific for altered base;","K10742","DNA2; DNA replication ATP-dependent helicase Dna2 [EC:3.6.4.12]"]
["ENSG00000010319",32,29,27,62.7320814246125,71,101,146,0.334482049505096,-1.57999930639692,3.00615704095411e-09,1.85961375900971e-08,"down","yes","SEMA3G","protein_coding","chr3:52433053-52445085:-","gi|9910362|ref|NP_064548.1|",3886,0,"semaphorin-3G precursor [Homo sapiens]","gi|675749909|ref|XM_003818759.2|",4744,0,"PREDICTED: Pan paniscus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G (SEMA3G), transcript variant X1, mRNA","Q9NS98",1503,0,"Semaphorin-3G",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0050919|negative chemotaxis;GO:0030517|negative regulation of axon extension;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;","GO:0038191|neuropilin binding;GO:0005102|receptor binding;","K06840","SEMA3; semaphorin 3"]
["ENSG00000168078",510,424,397,953.056154622238,1298,1526,1908,0.333893783976322,-1.58253885955764,8.10800023681033e-105,5.64574399161003e-103,"down","yes","PBK","protein_coding","chr8:27809620-27838095:-","gi|18490991|ref|NP_060962.2|",1619,0,"lymphokine-activated killer T-cell-originated protein kinase isoform 1 [Homo sapiens]","gi|525507088|ref|NM_018492.3|",2117,0,"Homo sapiens PDZ binding kinase (PBK), transcript variant 1, mRNA","Q96KB5",628,0,"Lymphokine-activated killer T-cell-originated protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0034644|cellular response to UV;GO:0000278|mitotic cell cycle;GO:0050728|negative regulation of inflammatory response;GO:0032435|negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032873|negative regulation of stress-activated MAPK cascade;","GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08865","PBK; PDZ-binding kinase [EC:2.7.12.2]"]
["ENSG00000138658",73,75,64,152.041471951731,209,228,320,0.333821265120426,-1.58285223453496,1.80480137444892e-20,2.20322841204878e-19,"down","yes","ZGRF1","protein_coding","chr4:112539333-112636995:-","gi|254826809|ref|NP_060862.3|",11010,0,"protein ZGRF1 [Homo sapiens]","gi|254826808|ref|NM_018392.4|",6652,0,"Homo sapiens zinc finger GRF-type containing 1 (ZGRF1), mRNA","Q86YA3",4245,0,"Protein ZGRF1","ECU10g1640",189,3e-48,"COG1112","pfam13087","AAA_12","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.",".","GO:0016021|integral component of membrane;","GO:0008270|zinc ion binding;",".","."]
["ENSG00000182010",74,63,91,164.60271234877,228,277,307,0.333169655529542,-1.58567108617246,5.44267911035667e-20,6.51230736231759e-19,"down","yes","RTKN2","protein_coding","chr10:62183035-62268707:-","gi|26190614|ref|NP_660350.2|",3284,0,"rhotekin-2 isoform 1 [Homo sapiens]","gi|545479157|ref|NM_145307.3|",6641,0,"Homo sapiens rhotekin 2 (RTKN2), transcript variant 1, mRNA","Q8IZC4",1269,0,"Rhotekin-2",".",".",".",".","pfam08174","Anillin","Cell division protein anillin. Anillin is a protein involved in septin organisation during cell division.  It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.","GO:0030097|hemopoiesis;GO:0007165|signal transduction;",".",".",".","."]
["ENSG00000140451",302,292,260,612.984672627084,806,988,1263,0.333148302953165,-1.58576355030514,6.41831234845241e-76,2.96873881479497e-74,"down","yes","PIF1","protein_coding","chr15:64815632-64825668:-","gi|694960005|ref|XP_009427602.1|",3052,0,"PREDICTED: ATP-dependent DNA helicase PIF1 isoform X1 [Pan troglodytes]","gi|557357741|ref|NM_025049.3|",2687,0,"Homo sapiens PIF1 5'-to-3' DNA helicase (PIF1), transcript variant 2, mRNA","Q9H611",1172,0,"ATP-dependent DNA helicase PIF1","SPBC887.14c",291,7e-84,"COG0507","pfam05970","PIF1","PIF1-like helicase. This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated. This family includes a large number of largely uncharacterized plant proteins. This family includes a P-loop motif that is involved in nucleotide binding.","GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0044806|G-quadruplex DNA unwinding;GO:0000002|mitochondrial genome maintenance;GO:0051974|negative regulation of telomerase activity;GO:0032211|negative regulation of telomere maintenance via telomerase;GO:0032204|regulation of telomere maintenance;GO:0000723|telomere maintenance;","GO:0005739|mitochondrion;GO:0000784|nuclear chromosome, telomeric region;GO:0005657|replication fork;","GO:0005524|ATP binding;GO:0043141|ATP-dependent 5'-3' DNA helicase activity;GO:0033682|ATP-dependent 5'-3' DNA/RNA helicase activity;GO:0000287|magnesium ion binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0010521|telomerase inhibitor activity;GO:0042162|telomeric DNA binding;","K15255","PIF1; ATP-dependent DNA helicase PIF1 [EC:3.6.4.12]"]
["ENSG00000137804",36,27,29,66.0045934001417,82,119,128,0.332778678539077,-1.58736509335349,6.16190667973377e-10,4.07861551265288e-09,"down","yes","NUSAP1","protein_coding","chr15:41332694-41381050:+","gi|341865562|ref|NP_001230072.1|",2091,0,"nucleolar and spindle-associated protein 1 isoform 5 [Homo sapiens]","gi|341865561|ref|NM_001243143.1|",2409,0,"Homo sapiens nucleolar and spindle associated protein 1 (NUSAP1), transcript variant 5, mRNA","Q9BXS6",799,0,"Nucleolar and spindle-associated protein 1",".",".",".",".","pfam08317","Spc7","Spc7 kinetochore protein. This domain is found in cell division proteins which are required for kinetochore-spindle association.","GO:0040001|establishment of mitotic spindle localization;GO:0007076|mitotic chromosome condensation;GO:0000281|mitotic cytokinesis;GO:0000070|mitotic sister chromatid segregation;GO:0045840|positive regulation of mitotic nuclear division;","GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0005876|spindle microtubule;","GO:0003677|DNA binding;GO:0008017|microtubule binding;GO:0003723|RNA binding;",".","."]
["ENSG00000160949",615,484,523,1166.88541092835,1561,1978,2252,0.3322308634492,-1.58974199245752,8.26563768151933e-115,6.56080739099362e-113,"down","yes","TONSL","protein_coding","chr8:144428775-144444444:-","gi|62087832|dbj|BAD92363.1|",3689,0,"I-kappa-B-related protein variant [Homo sapiens]","gi|62087831|dbj|AB209126.1|",6543,0,"Homo sapiens mRNA for I-kappa-B-related protein variant protein","Q96HA7",1335,0,"Tonsoku-like protein",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0042994|cytoplasmic sequestering of transcription factor;GO:0000724|double-strand break repair via homologous recombination;GO:0031297|replication fork processing;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0043596|nuclear replication fork;GO:0005654|nucleoplasm;","GO:0042393|histone binding;GO:0003714|transcription corepressor activity;","K09257","NFKBIL2; NF-kappa-B inhibitor-like protein 2"]
["ENSG00000237548",13,7,15,25.1934132512142,31,39,57,0.332202168065558,-1.58986660603252,0.000162594393650837,0.000602752386072908,"down","yes","TTLL11-IT1","lincRNA","chr9:121884636-121963719:-","gi|119607916|gb|EAW87510.1|",525,3e-63,"hCG2036833 [Homo sapiens]","gi|685844164|tpe|LN608313.1|",1052,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000053903.1 (TTLL11-IT1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13203","DUF2201_N","Putative metallopeptidase domain. This domain, found in various hypothetical bacterial proteins, has no known function. However, it is related to pfam01435.",".",".",".",".","."]
["ENSG00000071282",92,65,78,169.257075535891,231,292,314,0.332012696712951,-1.59068968122311,7.64238719482844e-22,9.91300364585414e-21,"down","yes","LMCD1","protein_coding","chr3:8501707-8574673:+","gi|635120436|ref|XP_007983282.1|",2015,0,"PREDICTED: LIM and cysteine-rich domains protein 1 [Chlorocebus sabaeus]","gi|29788797|gb|AC034187.6|",7236,0,"Homo sapiens chromosome 3 clone RP11-202A21 map 3p, complete sequence","Q9NZU5",692,0,"LIM and cysteine-rich domains protein 1",".",".",".",".","pfam06297","PET","PET Domain. This domain is suggested to be involved in protein-protein interactions. The family is found in conjunction with pfam00412.","GO:0044267|cellular protein metabolic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0010611|regulation of cardiac muscle hypertrophy;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003714|transcription corepressor activity;GO:0008270|zinc ion binding;",".","."]
["ENSG00000134222",868,833,736,1755.8828697158,2337,2868,3543,0.331561640834796,-1.59265098726519,9.55759988558875e-193,1.60301727472379e-190,"down","yes","PSRC1","protein_coding","chr1:109279556-109283186:-","gi|14249168|ref|NP_116025.1|",1315,7e-175,"proline/serine-rich coiled-coil protein 1 isoform a [Homo sapiens]","gi|33317121|gb|AF447874.1|",1870,0,"Homo sapiens FP3214 mRNA, complete cds","Q6PGN9",497,2e-170,"Proline/serine-rich coiled-coil protein 1",".",".",".",".","pfam15259","GTSE1_N","G-2 and S-phase expressed 1. This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.","GO:0051301|cell division;GO:0001578|microtubule bundle formation;GO:0007080|mitotic metaphase plate congression;GO:0030308|negative regulation of cell growth;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0031116|positive regulation of microtubule polymerization;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060236|regulation of mitotic spindle organization;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;GO:0005654|nucleoplasm;GO:0005819|spindle;GO:0000922|spindle pole;","GO:0008017|microtubule binding;",".","."]
["ENSG00000137135",123,83,87,210.21796840009,267,335,454,0.331547149556554,-1.59271404326916,9.69842690526532e-26,1.4729390405414e-24,"down","yes","ARHGEF39","protein_coding","chr9:35658875-35675866:-","gi|795353018|ref|XP_011746472.1|",1372,7e-174,"PREDICTED: rho guanine nucleotide exchange factor 39 isoform X3 [Macaca nemestrina]","gi|24270879|gb|BC038673.1|",4489,0,"Homo sapiens chromosome 9 open reading frame 100, mRNA (cDNA clone IMAGE:5266209), with apparent retained intron","Q8N4T4",519,1e-169,"Rho guanine nucleotide exchange factor 39",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0030335|positive regulation of cell migration;GO:0035023|regulation of Rho protein signal transduction;","GO:0005886|plasma membrane;","GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["ENSG00000184445",760,699,633,1509.57566075373,2095,2508,2870,0.331172461334387,-1.59434538445392,3.33779838079866e-149,3.78702677463792e-147,"down","yes","KNTC1","protein_coding","chr12:122527246-122626396:+","gi|7661960|ref|NP_055523.1|",11364,0,"kinetochore-associated protein 1 [Homo sapiens]","gi|156071508|ref|NM_014708.4|",6961,0,"Homo sapiens kinetochore associated 1 (KNTC1), mRNA","P50748",4382,0,"Kinetochore-associated protein 1",".",".",".",".","pfam10493","Rod_C","Rough deal protein C-terminal region. Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localizing first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10, and indeed the two proteins function together, localisation of each depending upon the other. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint.","GO:0051301|cell division;GO:0007093|mitotic cell cycle checkpoint;GO:0065003|macromolecular complex assembly;GO:0007096|regulation of exit from mitosis;","GO:0015629|actin cytoskeleton;GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005828|kinetochore microtubule;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:1990423|RZZ complex;GO:0000922|spindle pole;",".","K11577","KNTC1, ROD; kinetochore-associated protein 1"]
["ENSG00000112984",1223,1244,1123,2594.83238118757,3431,4214,5308,0.330547515806016,-1.59707042257824,4.97131965864862e-251,1.29576775102722e-248,"down","yes","KIF20A","protein_coding","chr5:138178719-138187715:+","gi|5032013|ref|NP_005724.1|",4113,0,"kinesin-like protein KIF20A [Homo sapiens]","gi|195539383|ref|NM_005733.2|",3201,0,"Homo sapiens kinesin family member 20A (KIF20A), mRNA","O95235",1588,0,"Kinesin-like protein KIF20A","YGL216w",113,1e-24,"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0000920|cell separation after cytokinesis;GO:0001578|microtubule bundle formation;GO:0007018|microtubule-based movement;GO:0000281|mitotic cytokinesis;GO:0015031|protein transport;GO:0032465|regulation of cytokinesis;GO:0016192|vesicle-mediated transport;","GO:0032154|cleavage furrow;GO:0005794|Golgi apparatus;GO:0045171|intercellular bridge;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030496|midbody;GO:0005654|nucleoplasm;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0019901|protein kinase binding;GO:0005215|transporter activity;","K10402","KIF20; kinesin family member 20"]
["ENSG00000273521",6,6,4,11.5578450189508,17,14,27,0.329264651628722,-1.60268045588835,0.00875428798653998,0.0235860744076523,"down","yes","AL162274.1","antisense","chr10:131980240-131981337:+",".",".",".",".","gi|666670244|tpe|LK938941.1|",1098,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473468.1 (RP11-45A17.4 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000075702",520,418,452,1009.88189201096,1345,1671,2027,0.327895222326039,-1.60869321412847,4.46112724693091e-114,3.51209070770626e-112,"down","yes","WDR62","protein_coding","chr19:36054881-36105106:+","gi|768008511|ref|XP_011525142.1|",2599,0,"PREDICTED: WD repeat-containing protein 62 isoform X5 [Homo sapiens]","gi|34366883|emb|BX647726.1|",5950,0,"Homo sapiens mRNA; cDNA DKFZp686G1024 (from clone DKFZp686G1024)","O43379",1002,0,"WD repeat-containing protein 62",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007099|centriole replication;GO:0021987|cerebral cortex development;GO:0007052|mitotic spindle organization;GO:0022008|neurogenesis;GO:0008380|RNA splicing;","GO:0071013|catalytic step 2 spliceosome;GO:0005814|centriole;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0005634|nucleus;GO:0071011|precatalytic spliceosome;GO:0000922|spindle pole;GO:0005682|U5 snRNP;","GO:0003723|RNA binding;",".","."]
["ENSG00000143375",92,84,81,187.659712332667,259,271,413,0.32563572923522,-1.6186690919586,1.53455884127096e-24,2.21215029375443e-23,"down","yes","CGN","protein_coding","chr1:151510510-151538692:+","gi|223462553|gb|AAI50605.1|",5177,0,"Cingulin [Homo sapiens]","gi|187608600|ref|NM_020770.2|",5091,0,"Homo sapiens cingulin (CGN), mRNA","Q9P2M7",1987,0,"Cingulin",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0005923|bicellular tight junction;GO:0030054|cell junction;GO:0016459|myosin complex;GO:0005886|plasma membrane;","GO:0003779|actin binding;GO:0045296|cadherin binding;GO:0003774|motor activity;","K06102","CGN; cingulin"]
["ENSG00000109674",169,138,94,291.855370651325,396,488,574,0.325101957555625,-1.62103585184805,5.49225859239764e-32,1.0385753306879e-30,"down","yes","NEIL3","protein_coding","chr4:177309836-177362943:+","gi|302393810|sp|Q8TAT5.3|NEIL3_HUMAN",3266,0,"RecName: Full=Endonuclease 8-like 3; AltName: Full=DNA glycosylase FPG2; AltName: Full=DNA glycosylase/AP lyase Neil3; AltName: Full=Endonuclease VIII-like 3; AltName: Full=Nei-like protein 3","gi|157388968|ref|NM_018248.2|",2399,0,"Homo sapiens nei like DNA glycosylase 3 (NEIL3), mRNA","Q8TAT5",1262,0,"Endonuclease 8-like 3","Cgl0824",72,6e-13,"COG0266","pfam06839","zf-GRF","GRF zinc finger. This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.","GO:0006284|base-excision repair;GO:0006289|nucleotide-excision repair;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000405|bubble DNA binding;GO:0003684|damaged DNA binding;GO:0019104|DNA N-glycosylase activity;GO:0003906|DNA-(apurinic or apyrimidinic site) lyase activity;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0008270|zinc ion binding;","K10569","NEIL3; endonuclease VIII-like 3"]
["ENSG00000183763",173,153,160,356.010743489766,432,639,722,0.324204783065705,-1.62502271947216,7.97136021621198e-44,2.02838516952898e-42,"down","yes","TRAIP","protein_coding","chr3:49828599-49856574:-","gi|40807469|ref|NP_005870.2|",2368,0,"E3 ubiquitin-protein ligase TRAIP [Homo sapiens]","gi|40807468|ref|NM_005879.2|",2020,0,"Homo sapiens TRAF interacting protein (TRAIP), mRNA","Q9BWF2",916,0,"E3 ubiquitin-protein ligase TRAIP",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0006915|apoptotic process;GO:0008283|cell proliferation;GO:0032688|negative regulation of interferon-beta production;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0007165|signal transduction;","GO:0005730|nucleolus;GO:0048471|perinuclear region of cytoplasm;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K11985","TRAIP, TRIP; TRAF-interacting protein [EC:2.3.2.27]"]
["ENSG00000104738",1676,1582,1454,3462.58330430621,4574,5742,7066,0.32301520411286,-1.6303260216648,0,0,"down","yes","MCM4","protein_coding","chr8:47960185-47978160:+","gi|940536|emb|CAA52801.1|",4478,0,"P1 Cdc21 protein [Homo sapiens]","gi|325651967|ref|NM_005914.3|",4183,0,"Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 1, mRNA","P33991",1677,0,"DNA replication licensing factor MCM4","YPR019w",640,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0006268|DNA unwinding involved in DNA replication;GO:0000082|G1/S transition of mitotic cell cycle;","GO:0042555|MCM complex;GO:0016020|membrane;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003678|DNA helicase activity;GO:0003697|single-stranded DNA binding;","K02212","MCM4, CDC54; DNA replication licensing factor MCM4 [EC:3.6.4.12]"]
["ENSG00000181544",99,90,74,193.569697093996,286,311,363,0.322686615329078,-1.63179435715806,9.56076471833997e-26,1.45317596443925e-24,"down","yes","FANCB","protein_coding","chrX:14835961-14873069:-","gi|22749293|ref|NP_689846.1|",4386,0,"Fanconi anemia group B protein [Homo sapiens]","gi|768032085|ref|XM_011545470.1|",1536,0,"PREDICTED: Homo sapiens Fanconi anemia, complementation group B (FANCB), transcript variant X1, mRNA","Q8NB91",1694,0,"Fanconi anemia group B protein",".",".",".",".","pfam08781","DP","Transcription factor DP. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.","GO:0036297|interstrand cross-link repair;","GO:0043240|Fanconi anaemia nuclear complex;GO:0005654|nucleoplasm;",".","K10889","FANCB; fanconi anemia group B protein"]
["ENSG00000169683",237,222,198,483.91091315754,626,802,1011,0.321595013331517,-1.63668305869909,5.53286001284057e-64,2.04832637097253e-62,"down","yes","LRRC45","protein_coding","chr17:82023302-82031151:+","gi|21450705|ref|NP_659436.1|",2901,0,"leucine-rich repeat-containing protein 45 [Homo sapiens]","gi|746817052|ref|NM_144999.3|",2701,0,"Homo sapiens leucine rich repeat containing 45 (LRRC45), mRNA","Q96CN5",1122,0,"Leucine-rich repeat-containing protein 45",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).",".","GO:0005813|centrosome;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000196584",243,190,192,461.298689662374,645,758,902,0.32102975262965,-1.63922108419985,4.77355883921776e-58,1.60684821799009e-56,"down","yes","XRCC2","protein_coding","chr7:152644779-152676165:-","gi|4885657|ref|NP_005422.1|",1260,2e-157,"DNA repair protein XRCC2 [Homo sapiens]","gi|51476243|emb|CR749256.1|",4681,0,"Homo sapiens mRNA; cDNA DKFZp781P0919 (from clone DKFZp781P0919)","O43543",489,7e-159,"DNA repair protein XRCC2","Ta1104",57,2e-07,"COG0468","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007098|centrosome cycle;GO:0006281|DNA repair;GO:0000724|double-strand break repair via homologous recombination;GO:0001701|in utero embryonic development;GO:0051321|meiotic cell cycle;GO:0000707|meiotic DNA recombinase assembly;GO:0000278|mitotic cell cycle;GO:0006312|mitotic recombination;GO:0035264|multicellular organism growth;GO:0043524|negative regulation of neuron apoptotic process;GO:0050769|positive regulation of neurogenesis;GO:0007131|reciprocal meiotic recombination;GO:2000269|regulation of fibroblast apoptotic process;GO:0010332|response to gamma radiation;GO:0010212|response to ionizing radiation;GO:0010165|response to X-ray;GO:0001756|somitogenesis;GO:0042148|strand invasion;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0033063|Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0005657|replication fork;","GO:0005524|ATP binding;GO:0008094|DNA-dependent ATPase activity;GO:0003690|double-stranded DNA binding;GO:0000150|recombinase activity;GO:0003697|single-stranded DNA binding;","K10879","XRCC2; DNA-repair protein XRCC2"]
["ENSG00000175305",56,54,51,119.427495046587,168,199,229,0.319959188982077,-1.64404019479962,6.89478934373754e-18,7.42113263738893e-17,"down","yes","CCNE2","protein_coding","chr8:94879770-94896678:-","gi|17318565|ref|NP_477097.1|",2038,0,"G1/S-specific cyclin-E2 [Homo sapiens]","gi|426360264|ref|XM_004047320.1|",3110,0,"PREDICTED: Gorilla gorilla gorilla cyclin E2 (CCNE2), mRNA","O96020",789,0,"G1/S-specific cyclin-E2",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0051301|cell division;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:1903827|regulation of cellular protein localization;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0007129|synapsis;GO:0000723|telomere maintenance;","GO:0097135|cyclin E2-CDK2 complex;GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0016538|cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901|protein kinase binding;","K06626","CCNE; cyclin E"]
["ENSG00000213397",14,12,6,23.5078540147651,26,44,50,0.319082638755581,-1.64799798098219,0.000168694975320505,0.000623331165513776,"down","yes","HAUS7","protein_coding","chrX:153447666-153495516:-","gi|6093223|emb|CAB59176.1|",898,5e-114,"hypothetical protein [Homo sapiens]","gi|6093222|emb|AL122036.1|",1927,0,"Homo sapiens mRNA; cDNA DKFZp434G1735 (from clone DKFZp434G1735); partial cds","Q99871",318,2e-100,"HAUS augmin-like complex subunit 7",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0051301|cell division;GO:0007098|centrosome cycle;GO:0000086|G2/M transition of mitotic cell cycle;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0070652|HAUS complex;GO:0005874|microtubule;GO:0005819|spindle;","GO:0031996|thioesterase binding;","K16590","HAUS7, UIP1; HAUS augmin-like complex subunit 7"]
["ENSG00000071539",424,419,410,930.920881389275,1215,1561,1917,0.318784034546578,-1.64934871730693,1.5252718537664e-116,1.23611107207758e-114,"down","yes","TRIP13","protein_coding","chr5:892643-919357:+","gi|426385258|ref|XP_004059139.1|",2423,0,"PREDICTED: pachytene checkpoint protein 2 homolog [Gorilla gorilla gorilla]","gi|426385257|ref|XM_004059091.1|",2503,0,"PREDICTED: Gorilla gorilla gorilla thyroid hormone receptor interactor 13 (TRIP13), mRNA","Q15645",885,0,"Pachytene checkpoint protein 2 homolog","YBR186w",191,6e-51,"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0006302|double-strand break repair;GO:0007144|female meiosis I;GO:0007141|male meiosis I;GO:0007094|mitotic spindle assembly checkpoint;GO:0001556|oocyte maturation;GO:0048477|oogenesis;GO:0007131|reciprocal meiotic recombination;GO:0007286|spermatid development;GO:0007283|spermatogenesis;GO:0007130|synaptonemal complex assembly;GO:0006366|transcription from RNA polymerase II promoter;","GO:0001673|male germ cell nucleus;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0003712|transcription cofactor activity;",".","."]
["ENSG00000160957",699,659,532,1407.94110466021,1977,2247,2847,0.316873241864456,-1.65802225738035,1.86388954660251e-137,1.8724323736911e-135,"down","yes","RECQL4","protein_coding","chr8:144511288-144517845:-","gi|284005309|ref|NP_004251.3|",5321,0,"ATP-dependent DNA helicase Q4 [Homo sapiens]","gi|34189401|gb|BC020496.2|",3877,0,"Homo sapiens cDNA clone IMAGE:3902674, containing frame-shift errors","O94761",2056,0,"ATP-dependent DNA helicase Q4","ZrecQ",216,5e-58,"COG0514","pfam00271","Helicase_C","Helicase conserved C-terminal domain. The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.","GO:0006284|base-excision repair;GO:0032508|DNA duplex unwinding;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0000733|DNA strand renaturation;GO:0000724|double-strand break repair via homologous recombination;GO:0007275|multicellular organismal development;GO:0000723|telomere maintenance;","GO:0000781|chromosome, telomeric region;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0005634|nucleus;","GO:0036310|annealing helicase activity;GO:0005524|ATP binding;GO:0043140|ATP-dependent 3'-5' DNA helicase activity;GO:0000405|bubble DNA binding;GO:0009378|four-way junction helicase activity;GO:0004386|helicase activity;GO:0032357|oxidized purine DNA binding;","K10730","RECQL4; ATP-dependent DNA helicase Q4 [EC:3.6.4.12]"]
["ENSG00000215784",108,109,98,235.856058597657,320,368,505,0.315259776522543,-1.66538698421685,2.04755880355243e-33,4.00947352313901e-32,"down","yes","FAM72D","protein_coding","chr1:145096000-145112696:+","gi|48675832|ref|NP_997301.2|",782,7e-96,"protein FAM72D [Homo sapiens]","gi|48675831|ref|NM_207418.2|",2393,0,"Homo sapiens family with sequence similarity 72 member D (FAM72D), mRNA","Q6L9T8",305,2e-97,"Protein FAM72D",".",".",".",".","pfam14976","FAM72","FAM72 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.",".","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSG00000158825",4,5,5,10.4840815914997,7,28,19,0.314769306041008,-1.66763322806159,0.0136615770254471,0.0352608721620266,"down","yes","CDA","protein_coding","chr1:20588948-20618908:+","gi|11386157|ref|NP_001776.1|",780,2e-101,"cytidine deaminase [Homo sapiens]","gi|80861461|ref|NM_001785.2|",960,0,"Homo sapiens cytidine deaminase (CDA), mRNA","P32320",305,7e-103,"Cytidine deaminase","CAC1544",130,6e-36,"COG0295","pfam00383","dCMP_cyt_deam_1","Cytidine and deoxycytidylate deaminase zinc-binding region.","GO:0007166|cell surface receptor signaling pathway;GO:0009972|cytidine deamination;GO:0019858|cytosine metabolic process;GO:0030308|negative regulation of cell growth;GO:0045980|negative regulation of nucleotide metabolic process;GO:0043312|neutrophil degranulation;GO:0051289|protein homotetramerization;GO:0043097|pyrimidine nucleoside salvage;GO:0008655|pyrimidine-containing compound salvage;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0034774|secretory granule lumen;","GO:0004126|cytidine deaminase activity;GO:0001882|nucleoside binding;GO:0042803|protein homodimerization activity;GO:0008270|zinc ion binding;","K01489","cdd, CDA; cytidine deaminase [EC:3.5.4.5]"]
["ENSG00000100167",22,14,25,45.6384519491342,41,90,106,0.314525401989363,-1.66875155681564,8.0311633412816e-07,3.95569659158937e-06,"down","yes","2020-09-03","protein_coding","chr22:41969475-41998221:+","gi|148672573|gb|EDL04520.1|",1881,0,"septin 3, isoform CRA_c, partial [Mus musculus]","gi|156602652|ref|NM_019106.5|",4649,0,"Homo sapiens septin 3 (SEPT3), transcript variant B, mRNA","Q9Z1S5",718,0,"Neuronal-specific septin-3","SPAC821.06",317,3e-96,"COG5019","pfam00735","Septin","Septin. Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0042734|presynaptic membrane;","GO:0005525|GTP binding;GO:0042802|identical protein binding;","K16938","SEPT3_9_12; septin 3/9/12"]
["ENSG00000223969",4,9,6,14.358954396648,20,24,28,0.314311008112378,-1.6697352943669,0.00259465422031399,0.00784415213188341,"down","yes","AC002456.1","antisense","chr7:90590619-90597353:-",".",".",".",".","gi|551862167|tpe|HG500396.1|",450,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000138093.2 (AC002456.2 gene), antisense",".",".",".",".",".",".",".",".","pfam10332","DUF2418","Protein of unknown function (DUF2418). This is a conserved 100 residue central region of a family of proteins found in fungi. It carries a characteristic EYD sequence motif. The function is not known.",".",".",".",".","."]
["ENSG00000278272",3,3,6,9.13481787759763,14,16,15,0.314139742214055,-1.67052162318637,0.016306388238372,0.0412482119792418,"down","yes","HIST1H3C","protein_coding","chr6:26045411-26045821:+","gi|635096702|ref|XP_007971598.1|",709,4e-93,"PREDICTED: histone H3.1-like [Chlorocebus sabaeus]","gi|118341330|gb|BC127610.1|",411,0,"Homo sapiens histone cluster 1, H3c, mRNA (cDNA clone MGC:156109 IMAGE:40002514), complete cds","Q6LED0",275,3e-94,"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["ENSG00000187741",354,341,319,762.379993246017,1061,1269,1501,0.314038575222585,-1.6709863100885,8.55027796536232e-100,5.6094476665275e-98,"down","yes","FANCA","protein_coding","chr16:89737549-89816657:-","gi|66880553|ref|NP_000126.2|",7333,0,"Fanconi anemia group A protein isoform a [Homo sapiens]","gi|66880552|ref|NM_000135.2|",5449,0,"Homo sapiens Fanconi anemia complementation group A (FANCA), transcript variant 1, mRNA","O15360",2811,0,"Fanconi anemia group A protein",".",".",".",".","pfam03511","Fanconi_A","Fanconi anaemia group A protein.","GO:0006281|DNA repair;GO:0008585|female gonad development;GO:0036297|interstrand cross-link repair;GO:0008584|male gonad development;GO:0007140|male meiosis;GO:0065003|macromolecular complex assembly;GO:2000348|regulation of CD40 signaling pathway;GO:0042127|regulation of cell proliferation;GO:0051090|regulation of sequence-specific DNA binding transcription factor activity;GO:0050727|regulation of inflammatory response;GO:0045589|regulation of regulatory T cell differentiation;","GO:0005737|cytoplasm;GO:0043240|Fanconi anaemia nuclear complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K10888","FANCA; fanconi anemia group A protein"]
["ENSG00000104953",2,8,4,10.6357241557674,15,19,19,0.313448771009621,-1.67369842171542,0.010740642821952,0.0283594139287898,"down","yes","TLE6","protein_coding","chr19:2977446-2995184:+","gi|221136834|ref|NP_001137458.1|",2892,0,"transducin-like enhancer protein 6 isoform 1 [Homo sapiens]","gi|221136833|ref|NM_001143986.1|",2008,0,"Homo sapiens transducin like enhancer of split 6 (TLE6), transcript variant 1, mRNA","Q9H808",1096,0,"Transducin-like enhancer protein 6",".",".",".",".","pfam07902","Gp58","gp58-like protein. Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.","GO:0060136|embryonic process involved in female pregnancy;GO:0006355|regulation of transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;",".",".","."]
["ENSG00000165507",27,20,18,48.8297716970143,64,81,103,0.312179747938761,-1.67955114660425,1.87189349162582e-08,1.08131421582746e-07,"down","yes","DEPP1","protein_coding","chr10:44970981-44978810:-","gi|5901938|ref|NP_008952.1|",970,1e-123,"protein DEPP [Homo sapiens]","gi|4204189|dbj|AB022718.1|",2087,0,"Homo sapiens mRNA for DEPP (decidual protein induced by progesterone), complete cds","Q5RBE4",378,4e-125,"Protein DEPP",".",".",".",".","pfam15343","DEPP","Decidual protein induced by progesterone family. DEPP is a family of proteins expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels are found during the first trimester. Its expression is induced by progesterone, testosterone and, to a much lower extent, oestrogen. The family is alternatively known as fasting-induced gene protein, FIG.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSG00000267374",28,32,36,72.9357422374053,106,120,139,0.311829251529441,-1.68117182670721,1.391942544341e-11,1.04547460261874e-10,"down","yes","AC016205.1","lincRNA","chr18:39206924-39800318:-",".",".",".",".","gi|551887525|tpe|HG509935.1|",2306,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000441462.1 (RP11-244M2.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam14897","EpsG","EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.",".",".",".",".","."]
["ENSG00000105855",7,2,6,11.3699048721629,17,18,22,0.310275757995127,-1.68837711212462,0.00714531923510633,0.0196547229615988,"down","yes","ITGB8","protein_coding","chr7:20330702-20415754:+","gi|4504779|ref|NP_002205.1|",3934,0,"integrin beta-8 precursor [Homo sapiens]","gi|91984778|ref|NM_002214.2|",8751,0,"Homo sapiens integrin subunit beta 8 (ITGB8), mRNA","P26012",1519,0,"Integrin beta-8",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0051216|cartilage development;GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0001573|ganglioside metabolic process;GO:0007229|integrin-mediated signaling pathway;GO:0010629|negative regulation of gene expression;GO:0060674|placenta blood vessel development;GO:0045766|positive regulation of angiogenesis;GO:0010628|positive regulation of gene expression;","GO:0009986|cell surface;GO:0070062|extracellular exosome;GO:0034686|integrin alphav-beta8 complex;GO:0008305|integrin complex;GO:0005886|plasma membrane;","GO:1990430|extracellular matrix protein binding;GO:0038023|signaling receptor activity;GO:0005102|receptor binding;","K06591","ITGB8; integrin beta 8"]
["ENSG00000092470",250,211,199,500.762550995866,690,830,1012,0.309493290917206,-1.69201995932629,1.79661623653505e-69,7.32624396834843e-68,"down","yes","WDR76","protein_coding","chr15:43826963-43868419:+","gi|269847398|ref|NP_079184.2|",3105,0,"WD repeat-containing protein 76 isoform 1 [Homo sapiens]","gi|269847397|ref|NM_024908.3|",3978,0,"Homo sapiens WD repeat domain 76 (WDR76), transcript variant 1, mRNA","Q9H967",1199,0,"WD repeat-containing protein 76",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006974|cellular response to DNA damage stimulus;GO:2000001|regulation of DNA damage checkpoint;","GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["ENSG00000139209",52,30,26,81.4458617811892,105,149,159,0.30923479776112,-1.69322542202601,6.39580367603893e-12,4.92071245725723e-11,"down","yes","SLC38A4","protein_coding","chr12:46764761-46832408:-","gi|18482385|ref|NP_060488.2|",2666,0,"sodium-coupled neutral amino acid transporter 4 [Homo sapiens]","gi|219689131|ref|NM_001143824.1|",3788,0,"Homo sapiens solute carrier family 38 member 4 (SLC38A4), transcript variant 2, mRNA","Q969I6",1031,0,"Sodium-coupled neutral amino acid transporter 4","YEL064c",70.1,2e-11,"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006865|amino acid transport;GO:0006814|sodium ion transport;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0015293|symporter activity;","K14991","SLC38A4, SNAT4; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 4"]
["ENSG00000154920",90,82,65,179.84054284874,225,314,379,0.308398367951071,-1.69713296437866,2.7313515231332e-26,4.25543684799621e-25,"down","yes","EME1","protein_coding","chr17:50373220-50381483:+","gi|260763969|ref|NP_001159603.1|",2832,0,"crossover junction endonuclease EME1 isoform 1 [Homo sapiens]","gi|260763968|ref|NM_001166131.1|",2354,0,"Homo sapiens essential meiotic structure-specific endonuclease 1 (EME1), transcript variant 1, mRNA","Q96AY2",1035,0,"Crossover junction endonuclease EME1",".",".",".",".","pfam10328","7TM_GPCR_Srx","Serpentine type 7TM GPCR chemoreceptor Srx. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.","GO:0006302|double-strand break repair;GO:0036297|interstrand cross-link repair;GO:0031573|intra-S DNA damage checkpoint;GO:0031297|replication fork processing;GO:0000712|resolution of meiotic recombination intermediates;GO:0072429|response to intra-S DNA damage checkpoint signaling;","GO:0048476|Holliday junction resolvase complex;GO:0000790|nuclear chromatin;GO:0005720|nuclear heterochromatin;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0004520|endodeoxyribonuclease activity;GO:0046872|metal ion binding;","K10882","EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]"]
["ENSG00000101447",908,891,764,1952.668300167,2677,3196,4026,0.308040757320548,-1.69880684625913,3.32737693042255e-221,7.0525765092297e-219,"down","yes","FAM83D","protein_coding","chr20:38926312-38953106:+","gi|116235448|ref|NP_112181.2|",2725,0,"protein FAM83D [Homo sapiens]","gi|116235447|ref|NM_030919.2|",2429,0,"Homo sapiens family with sequence similarity 83 member D (FAM83D), mRNA","Q9H4H8",1008,0,"Protein FAM83D",".",".",".",".","pfam07894","DUF1669","Protein of unknown function (DUF1669). This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.","GO:0051301|cell division;GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0001837|epithelial to mesenchymal transition;GO:0051310|metaphase plate congression;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1902480|protein localization to mitotic spindle;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0042176|regulation of protein catabolic process;GO:0032006|regulation of TOR signaling;","GO:0005737|cytoplasm;GO:0097431|mitotic spindle pole;","GO:0019894|kinesin binding;GO:0008017|microtubule binding;GO:0019901|protein kinase binding;","K16805","FAM83D, CHICA; protein FAM83D"]
["ENSG00000183128",3,8,2,10.0546611168163,22,12,14,0.306879038547453,-1.7042579893776,0.0163788738710921,0.0414152752000033,"down","yes","CALHM3","protein_coding","chr10:103472804-103479240:-","gi|193211395|ref|NP_001123214.1|",1606,0,"calcium homeostasis modulator protein 3 [Homo sapiens]","gi|193211394|ref|NM_001129742.1|",1652,0,"Homo sapiens calcium homeostasis modulator 3 (CALHM3), mRNA","Q86XJ0",597,0,"Calcium homeostasis modulator protein 3",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0034220|ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSG00000179750",149,174,167,376.237911760941,510,611,792,0.306119214396833,-1.70783449254114,1.61432795856891e-50,4.7610332820913e-49,"down","yes","APOBEC3B","protein_coding","chr22:38982347-38992804:+","gi|119580683|gb|EAW60279.1|",2310,0,"apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B, isoform CRA_a [Homo sapiens]","gi|10437262|dbj|AK024854.1|",1788,0,"Homo sapiens cDNA: FLJ21201 fis, clone COL00275, highly similar to HSU61084 Homo sapiens phorbolin-1-related protein mRNA","Q9UH17",795,0,"DNA dC->dU-editing enzyme APOBEC-3B",".",".",".",".","pfam08210","APOBEC_N","APOBEC-like N-terminal domain. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.","GO:0051607|defense response to virus;GO:0045087|innate immune response;GO:0010529|negative regulation of transposition;","GO:0005634|nucleus;","GO:0047844|deoxycytidine deaminase activity;GO:0003723|RNA binding;GO:0008270|zinc ion binding;","K18750","APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]"]
["ENSG00000248890",10,3,6,14.4486959663895,20,21,33,0.305731691989387,-1.70966198588757,0.00232370416372854,0.00709395471826465,"down","yes","HHIP-AS1","antisense","chr4:144642922-144661357:-","gi|119625460|gb|EAX05055.1|",372,1e-40,"hCG2041184, partial [Homo sapiens]","gi|551854207|tpe|HG497345.1|",1094,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000364894.1 (RP11-291L15.2 gene), antisense",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSG00000278023",19,10,5,25.7251180387986,31,48,53,0.304990772443428,-1.71316250057738,8.32324233143679e-05,0.000320692565099386,"down","yes","RDM1","protein_coding","chr17:35918066-35930773:-","gi|253314472|ref|NP_001156602.1|",1375,0,"RAD52 motif-containing protein 1 isoform 8 [Homo sapiens]","gi|34192903|gb|BC038301.2|",1532,0,"Homo sapiens RAD52 motif 1, mRNA (cDNA clone IMAGE:5268498), with apparent retained intron","Q8NG50",517,0,"RAD52 motif-containing protein 1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0015030|Cajal body;GO:0005829|cytosol;GO:0005730|nucleolus;GO:0016605|PML body;","GO:0003677|DNA binding;GO:0003723|RNA binding;","K10874","RDM1, RAD52B; RAD52 motif-containing protein 1"]
["ENSG00000183048",39,43,41,94.7121752925315,126,165,190,0.304747621009403,-1.71431313629399,1.85114490776289e-15,1.75540230978026e-14,"down","yes","SLC25A10","protein_coding","chr17:81712236-81721016:+","gi|401461821|ref|NP_001257817.1|",1475,0,"mitochondrial dicarboxylate carrier isoform 1 [Homo sapiens]","gi|401461820|ref|NM_001270888.1|",1946,0,"Homo sapiens solute carrier family 25 member 10 (SLC25A10), transcript variant 1, mRNA","Q9UBX3",545,0,"Mitochondrial dicarboxylate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006835|dicarboxylic acid transport;GO:0006094|gluconeogenesis;GO:0006811|ion transport;GO:0071423|malate transmembrane transport;GO:0006839|mitochondrial transport;GO:0015729|oxaloacetate transport;GO:0035435|phosphate ion transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0008272|sulfate transport;GO:0070221|sulfide oxidation, using sulfide:quinone oxidoreductase;GO:0015709|thiosulfate transport;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0015297|antiporter activity;GO:0005310|dicarboxylic acid transmembrane transporter activity;GO:0015140|malate transmembrane transporter activity;GO:0015131|oxaloacetate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015117|thiosulfate transmembrane transporter activity;","K13577","SLC25A10, DIC; solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10"]
["ENSG00000198554",719,649,613,1523.26982418613,2119,2533,3072,0.304505451862999,-1.71546003652488,1.16366104487505e-193,1.98625612686282e-191,"down","yes","WDHD1","protein_coding","chr14:54938950-55027105:-","gi|5901892|ref|NP_009017.1|",5761,0,"WD repeat and HMG-box DNA-binding protein 1 isoform 1 [Homo sapiens]","gi|300794717|ref|NM_007086.3|",5996,0,"Homo sapiens WD repeat and HMG-box DNA binding protein 1 (WDHD1), transcript variant 1, mRNA","O75717",2203,0,"WD repeat and HMG-box DNA-binding protein 1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0070829|heterochromatin maintenance;GO:0033044|regulation of chromosome organization;GO:0006396|RNA processing;","GO:0000775|chromosome, centromeric region;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0070063|RNA polymerase binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K11274","WDHD1, CTF4; chromosome transmission fidelity protein 4"]
["ENSG00000130600",3,5,6,10.9373567344519,19,16,19,0.30402398060046,-1.71774297079456,0.00736005198395342,0.0201620057756702,"down","yes","H19","processed_transcript","chr11:1995176-2001470:-","gi|686735234|ref|XP_009244297.1|",1221,2e-157,"PREDICTED: spidroin-2 [Pongo abelii]","gi|802084044|ref|NR_002196.2|",2348,0,"Homo sapiens H19, imprinted maternally expressed transcript (non-protein coding) (H19), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.",".",".",".",".","."]
["ENSG00000105486",374,378,330,833.169570177833,1078,1426,1754,0.303652329387702,-1.71950765840744,2.03605691154788e-109,1.49891090495937e-107,"down","yes","LIG1","protein_coding","chr19:48115445-48170603:-","gi|62087162|dbj|BAD92028.1|",3725,0,"DNA ligase I variant [Homo sapiens]","gi|574288617|ref|NR_110296.1|",4102,0,"Homo sapiens ligase I, DNA, ATP-dependent (LIG1), transcript variant 4, non-coding RNA","P18858",1349,0,"DNA ligase 1","YDL164c",424,5e-130,"COG1793","pfam01068","DNA_ligase_A_M","ATP dependent DNA ligase domain. This domain belongs to a more diverse superfamily, including pfam01331 and pfam01653.","GO:0009653|anatomical structure morphogenesis;GO:0006284|base-excision repair;GO:0051301|cell division;GO:0071897|DNA biosynthetic process;GO:0006266|DNA ligation;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0006298|mismatch repair;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:1903461|Okazaki fragment processing involved in mitotic DNA replication;GO:0006283|transcription-coupled nucleotide-excision repair;","GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003910|DNA ligase (ATP) activity;GO:0003909|DNA ligase activity;GO:0046872|metal ion binding;","K10747","LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"]
["ENSG00000154080",6,3,8,13.186793826435,17,20,31,0.301757117064353,-1.7285402969564,0.00309794914603848,0.00922260273634669,"down","yes","CHST9","protein_coding","chr18:26906481-27185317:-","gi|116235458|ref|NP_113610.2|",2400,0,"carbohydrate sulfotransferase 9 isoform 1 [Homo sapiens]","gi|7528027|gb|AC010854.3|AC010854",10870,0,"Homo sapiens chromosome 18, clone RP11-349N23, complete sequence","Q7L1S5",929,0,"Carbohydrate sulfotransferase 9",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0016051|carbohydrate biosynthetic process;GO:0030206|chondroitin sulfate biosynthetic process;GO:0030203|glycosaminoglycan metabolic process;GO:0042446|hormone biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0006790|sulfur compound metabolic process;","GO:0005576|extracellular region;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0047756|chondroitin 4-sulfotransferase activity;GO:0001537|N-acetylgalactosamine 4-O-sulfotransferase activity;","K09673","CHST9; carbohydrate 4-sulfotransferase 9 [EC:2.8.2.-]"]
["ENSG00000136492",243,238,213,537.753739980401,759,868,1107,0.301672068689313,-1.72894696893255,1.76224758732096e-76,8.1904172203004e-75,"down","yes","BRIP1","protein_coding","chr17:61681266-61863521:-","gi|301897118|ref|NP_114432.2|",6666,0,"Fanconi anemia group J protein [Homo sapiens]","gi|301897117|ref|NM_032043.2|",6048,0,"Homo sapiens BRCA1 interacting protein C-terminal helicase 1 (BRIP1), mRNA","Q9BX63",2567,0,"Fanconi anemia group J protein","ECU02g1090",341,1e-99,"COG1199","pfam06733","DEAD_2","DEAD_2. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.","GO:1904385|cellular response to angiotensin;GO:0071456|cellular response to hypoxia;GO:0071295|cellular response to vitamin;GO:0051026|chiasma assembly;GO:0000077|DNA damage checkpoint;GO:0006260|DNA replication;GO:0006302|double-strand break repair;GO:0010705|meiotic DNA double-strand break processing involved in reciprocal meiotic recombination;GO:0008285|negative regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0009636|response to toxic substance;GO:0072520|seminiferous tubule development;GO:0007286|spermatid development;GO:0007284|spermatogonial cell division;","GO:0005737|cytoplasm;GO:0031965|nuclear membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0005524|ATP binding;GO:0004003|ATP-dependent DNA helicase activity;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0046872|metal ion binding;","K15362","BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:3.6.4.12]"]
["ENSG00000065618",53,56,53,125.913849509894,186,190,263,0.301249128604248,-1.73097102669048,1.21112946528057e-19,1.42353839892332e-18,"down","yes","COL17A1","protein_coding","chr10:104031286-104085957:-","gi|179517|gb|AAA35605.1|",2784,0,"autoantigen, partial [Homo sapiens]","gi|119829186|ref|NM_000494.3|",5610,0,"Homo sapiens collagen type XVII alpha 1 (COL17A1), mRNA","Q9UMD9",1001,0,"Collagen alpha-1(XVII) chain",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.","GO:0007160|cell-matrix adhesion;GO:0008544|epidermis development;GO:0031581|hemidesmosome assembly;GO:0050776|regulation of immune response;","GO:0005604|basement membrane;GO:0005911|cell-cell junction;GO:0005581|collagen trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0030056|hemidesmosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;",".","K07603","COL17A, BP180; collagen, type XVII, alpha"]
["ENSG00000011426",3403,3163,3089,7489.06162209678,10179,12565,15433,0.301178742330784,-1.73130814896863,0,0,"down","yes","ANLN","protein_coding","chr7:36389806-36453791:+","gi|31657094|ref|NP_061155.2|",5623,0,"actin-binding protein anillin isoform 1 [Homo sapiens]","gi|697272137|ref|NM_018685.4|",4787,0,"Homo sapiens anillin actin binding protein (ANLN), transcript variant 1, mRNA","Q9NQW6",2144,0,"Anillin",".",".",".",".","pfam08174","Anillin","Cell division protein anillin. Anillin is a protein involved in septin organisation during cell division.  It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.","GO:0090521|glomerular visceral epithelial cell migration;GO:0002244|hematopoietic progenitor cell differentiation;GO:0000281|mitotic cytokinesis;GO:1904172|positive regulation of bleb assembly;GO:0007096|regulation of exit from mitosis;GO:0000921|septin ring assembly;","GO:0015629|actin cytoskeleton;GO:0005826|actomyosin contractile ring;GO:0032059|bleb;GO:0099738|cell cortex region;GO:0030496|midbody;GO:0005654|nucleoplasm;","GO:0003779|actin binding;GO:0045296|cadherin binding;","K18621","ANLN; actin-binding protein anillin"]
["ENSG00000144230",11,6,3,15.2981074212244,15,31,34,0.299761779910393,-1.73811164572034,0.00180965061753487,0.00565060404698933,"down","yes","GPR17","protein_coding","chr2:127645864-127652639:+","gi|4885301|ref|NP_005282.1|",1824,0,"uracil nucleotide/cysteinyl leukotriene receptor isoform a [Homo sapiens]","gi|238814301|ref|NM_001161415.1|",2598,0,"Homo sapiens G protein-coupled receptor 17 (GPR17), transcript variant 1, mRNA","Q13304",707,0,"Uracil nucleotide/cysteinyl leukotriene receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0002376|immune system process;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0035025|positive regulation of Rho protein signal transduction;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0004950|chemokine receptor activity;GO:0033612|receptor serine/threonine kinase binding;","K08404","GPR17; G protein-coupled receptor 17"]
["ENSG00000132688",433,421,404,981.50610062682,1351,1621,2038,0.299056212205821,-1.74151140829549,3.95740901667478e-137,3.93456211925893e-135,"down","yes","NES","protein_coding","chr1:156668763-156677397:-","gi|119573310|gb|EAW52925.1|",6644,0,"nestin, isoform CRA_c [Homo sapiens]","gi|38176299|ref|NM_006617.1|",5558,0,"Homo sapiens nestin (NES), mRNA","P48681",2563,0,"Nestin",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007420|brain development;GO:0007417|central nervous system development;GO:0031076|embryonic camera-type eye development;GO:0000086|G2/M transition of mitotic cell cycle;GO:0043086|negative regulation of catalytic activity;GO:0032091|negative regulation of protein binding;GO:0030844|positive regulation of intermediate filament depolymerization;GO:2000179|positive regulation of neural precursor cell proliferation;GO:0072089|stem cell proliferation;","GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045111|intermediate filament cytoskeleton;","GO:0019215|intermediate filament binding;GO:0005198|structural molecule activity;","K07609","NES; nestin"]
["ENSG00000178999",575,540,462,1229.71283192171,1661,1975,2675,0.298350963217994,-1.74491766028521,1.55331647297495e-144,1.67376358272295e-142,"down","yes","AURKB","protein_coding","chr17:8204733-8210600:-","gi|33870194|gb|AAH13300.2|",1827,0,"AURKB protein, partial [Homo sapiens]","gi|548960891|ref|NM_001284526.1|",1254,0,"Homo sapiens aurora kinase B (AURKB), transcript variant 3, mRNA","Q96GD4",682,0,"Aurora kinase B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0009838|abscission;GO:0007568|aging;GO:0031145|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0008283|cell proliferation;GO:0034644|cellular response to UV;GO:0036089|cleavage furrow formation;GO:0043988|histone H3-S28 phosphorylation;GO:0016570|histone modification;GO:0044878|cytokinesis checkpoint;GO:0051256|mitotic spindle midzone assembly;GO:0002903|negative regulation of B cell apoptotic process;GO:0032466|negative regulation of cytokinesis;GO:0032091|negative regulation of protein binding;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032467|positive regulation of cytokinesis;GO:0051973|positive regulation of telomerase activity;GO:1904355|positive regulation of telomere capping;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0046777|protein autophosphorylation;GO:0034501|protein localization to kinetochore;GO:0006468|protein phosphorylation;GO:0051983|regulation of chromosome segregation;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0031577|spindle checkpoint;GO:0007051|spindle organization;","GO:0010369|chromocenter;GO:0032133|chromosome passenger complex;GO:0000779|condensed chromosome, centromeric region;GO:0000780|condensed nuclear chromosome, centromeric region;GO:0005829|cytosol;GO:0030496|midbody;GO:1990023|mitotic spindle midzone;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005819|spindle;GO:0005876|spindle microtubule;GO:0051233|spindle midzone;GO:0031616|spindle pole centrosome;","GO:0005524|ATP binding;GO:0035174|histone serine kinase activity;GO:0019900|kinase binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;","K11479","AURKB; aurora kinase B [EC:2.7.11.1]"]
["ENSG00000147234",17,15,13,35.0709725360709,48,55,77,0.298310442087397,-1.74511361609443,7.54493709877353e-07,3.72476956132951e-06,"down","yes","FRMPD3","protein_coding","chrX:107522450-107605251:+","gi|565324143|ref|NP_115804.1|",8742,0,"FERM and PDZ domain-containing protein 3 [Homo sapiens]","gi|565324142|ref|NM_032428.1|",7304,0,"Homo sapiens FERM and PDZ domain containing 3 (FRMPD3), mRNA","Q5JV73",3372,0,"FERM and PDZ domain-containing protein 3",".",".",".",".","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.","GO:0043312|neutrophil degranulation;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;GO:0070821|tertiary granule membrane;",".",".","."]
["ENSG00000111247",206,218,174,467.518638220792,675,751,952,0.298255018800468,-1.74538168022712,4.70275130012544e-64,1.74435898224653e-62,"down","yes","RAD51AP1","protein_coding","chr12:4538798-4560048:+","gi|195947391|ref|NP_001124334.1|",941,6e-117,"RAD51-associated protein 1 isoform a [Homo sapiens]","gi|195947390|ref|NM_001130862.1|",1877,0,"Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA","Q96B01",367,2e-118,"RAD51-associated protein 1",".",".",".",".","pfam05795","Plasmodium_Vir","Plasmodium vivax Vir protein. This family consists of several Vir proteins specific to Plasmodium vivax. The vir genes are present at about 600-1,000 copies per haploid genome and encode proteins that are immunovariant in natural infections, indicating that they may have a functional role in establishing chronic infection through antigenic variation.","GO:0071479|cellular response to ionizing radiation;GO:0006281|DNA repair;GO:0000724|double-strand break repair via homologous recombination;GO:0036297|interstrand cross-link repair;GO:0010569|regulation of double-strand break repair via homologous recombination;","GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003690|double-stranded DNA binding;GO:0003723|RNA binding;GO:0003697|single-stranded DNA binding;",".","."]
["ENSG00000165490",355,291,273,717.076341318259,957,1212,1506,0.297876201124406,-1.74721523108959,4.46864630696101e-98,2.8634966766998e-96,"down","yes","DDIAS","protein_coding","chr11:82899975-82958277:+","gi|194239694|ref|NP_659455.3|",5196,0,"DNA damage-induced apoptosis suppressor protein [Homo sapiens]","gi|194239693|ref|NM_145018.3|",3533,0,"Homo sapiens DNA damage induced apoptosis suppressor (DDIAS), mRNA","Q8IXT1",2006,0,"DNA damage-induced apoptosis suppressor protein",".",".",".",".","pfam08646","Rep_fac-A_C","Replication factor-A C terminal domain. This domain is found at the C terminal of replication factor A. Replication factor A (RPA) binds single-stranded DNA and is involved in replication, repair, and recombination of DNA.","GO:0006915|apoptotic process;GO:0007050|cell cycle arrest;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["ENSG00000100234",145,157,157,360.14923930444,489,624,724,0.297605052336678,-1.7485290761054,2.37758536163823e-52,7.19919410600915e-51,"down","yes","TIMP3","protein_coding","chr22:32801701-32863043:+","gi|332218050|ref|XP_003258172.1|",1141,1e-139,"PREDICTED: metalloproteinase inhibitor 3 isoform X1 [Nomascus leucogenys]","gi|75905820|ref|NM_000362.4|",4601,0,"Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA","Q5PXZ9",437,7e-141,"Metalloproteinase inhibitor 3",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0071310|cellular response to organic substance;GO:0043086|negative regulation of catalytic activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:1904684|negative regulation of metalloendopeptidase activity;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:0010033|response to organic substance;","GO:0005604|basement membrane;GO:0005615|extracellular space;","GO:0008191|metalloendopeptidase inhibitor activity;GO:0002020|protease binding;GO:0008270|zinc ion binding;","K16866","TIMP3; metalloproteinase inhibitor 3"]
["ENSG00000241472",17,30,30,60.9630494454953,91,100,117,0.296857832631094,-1.75215591558924,6.50113782084471e-10,4.28990579159948e-09,"down","yes","PTPRG-AS1","processed_transcript","chr3:62260865-62369330:-","gi|119585803|gb|EAW65399.1|",488,2e-54,"hCG2041530, isoform CRA_b [Homo sapiens]","gi|333944046|ref|NR_038282.1|",2653,0,"Homo sapiens PTPRG antisense RNA 1 (PTPRG-AS1), transcript variant 2, long non-coding RNA","Q8WTZ3",120,1e-28,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000250548",10,2,4,12.2917143184778,8,27,31,0.296280140143175,-1.75496617016496,0.00721295203757475,0.0198096851631414,"down","yes","LINC01303","lincRNA","chr14:61556313-61570653:-","gi|119601210|gb|EAW80804.1|",265,1e-23,"hCG1816156, isoform CRA_b [Homo sapiens]","gi|577861089|ref|NR_110416.1|",5103,0,"Homo sapiens uncharacterized LOC101927780 (LOC101927780), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000085840",172,218,161,434.792882941869,600,749,871,0.295052395173728,-1.76095692500516,6.33848934839497e-56,2.07214885681088e-54,"down","yes","ORC1","protein_coding","chr1:52372829-52404459:-","gi|31795544|ref|NP_004144.2|",4269,0,"origin recognition complex subunit 1 isoform 1 [Homo sapiens]","gi|299890791|ref|NM_004153.3|",3157,0,"Homo sapiens origin recognition complex subunit 1 (ORC1), transcript variant 1, mRNA","Q13415",1646,0,"Origin recognition complex subunit 1","SPBC29A10.15",283,4e-81,"COG1474","pfam01426","BAH","BAH domain. This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.","GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;","GO:0005829|cytosol;GO:0000784|nuclear chromosome, telomeric region;GO:0005664|nuclear origin of replication recognition complex;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000808|origin recognition complex;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0003677|DNA binding;","K02603","ORC1; origin recognition complex subunit 1"]
["ENSG00000167670",632,603,574,1429.76335659486,1930,2375,3045,0.293767305705833,-1.76725425216095,4.29820395192121e-193,7.27225945830318e-191,"down","yes","CHAF1A","protein_coding","chr19:4402662-4445018:+","gi|50513245|ref|NP_005474.2|",2321,0,"chromatin assembly factor 1 subunit A [Homo sapiens]","gi|50513244|ref|NM_005483.2|",3338,0,"Homo sapiens chromatin assembly factor 1 subunit A (CHAF1A), mRNA","Q13111",898,0,"Chromatin assembly factor 1 subunit A",".",".",".",".","pfam15539","CAF1-p150_C2","CAF1 complex subunit p150, region binding to CAF1-p60 at C-term. CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork.","GO:0007049|cell cycle;GO:0031497|chromatin assembly;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0006335|DNA replication-dependent nucleosome assembly;","GO:0033186|CAF-1 complex;GO:0000790|nuclear chromatin;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0070087|chromo shadow domain binding;GO:0042802|identical protein binding;GO:0051082|unfolded protein binding;","K10750","CHAF1A; chromatin assembly factor 1 subunit A"]
["ENSG00000177822",2,6,2,7.91927760089513,11,11,19,0.293581584704074,-1.76816661883613,0.019898312247702,0.0489601539269902,"down","yes","AC098864.1","antisense","chr4:181874438-182145249:-","gi|119625112|gb|EAX04707.1|",650,5e-77,"hypothetical protein LOC90768, isoform CRA_a [Homo sapiens]","gi|675402568|ref|NR_027107.2|",2260,0,"Homo sapiens uncharacterized LOC90768 (LOC90768), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam15238","FAM181","FAM181. This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 426 amino acids in length.",".",".",".",".","."]
["ENSG00000214796",9,8,9,20.534531083352,27,29,51,0.293375615187476,-1.76917913290844,0.000147859388764477,0.000551094085118692,"down","yes","AC098934.1","transcribed_unprocessed_pseudogene","chr1:202851828-202861620:-","gi|119611847|gb|EAW91441.1|",560,1e-65,"hCG2038243, isoform CRA_b [Homo sapiens]","gi|26252053|gb|BC040684.1|",1736,0,"Homo sapiens, clone IMAGE:5459526, mRNA","P02553",116,2e-28,"Tubulin alpha chain (Fragment)","SPBC16A3.15c",100,7e-22,"COG5023","pfam00091","Tubulin","Tubulin/FtsZ family, GTPase domain. This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.","GO:0007017|microtubule-based process;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005525|GTP binding;GO:0005200|structural constituent of cytoskeleton;",".","."]
["ENSG00000160298",48,43,57,117.747731454274,159,216,226,0.292782464312692,-1.77209894634297,1.20229911444285e-18,1.34512443847875e-17,"down","yes","C21orf58","protein_coding","chr21:46300181-46323875:-","gi|40068065|ref|NP_478060.2|",952,2e-116,"uncharacterized protein C21orf58 isoform 1 [Homo sapiens]","gi|557129053|ref|NM_058180.4|",2967,0,"Homo sapiens chromosome 21 open reading frame 58 (C21orf58), transcript variant 1, mRNA",".",".",".",".",".",".",".",".","pfam15248","DUF4587","Domain of unknown function (DUF4587). This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.",".",".",".",".","."]
["ENSG00000137310",461,427,421,1038.14633245666,1444,1717,2162,0.292697929031719,-1.7725155568149,1.57618658284227e-148,1.77786472572291e-146,"down","yes","TCF19","protein_coding","chr6:31158542-31167159:+","gi|117414152|ref|NP_001070979.1|",1444,0,"transcription factor 19 [Homo sapiens]","gi|117414155|ref|NM_007109.2|",3290,0,"Homo sapiens transcription factor 19 (TCF19), transcript variant 1, mRNA","Q9Y242",560,0,"Transcription factor 19",".",".",".",".","pfam00498","FHA","FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.","GO:0008283|cell proliferation;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000226674",9,10,9,22.1772951636765,26,37,53,0.292037361932018,-1.77577514213168,7.10102449741304e-05,0.000275693559794893,"down","yes","TEX41","lincRNA","chr2:144667967-145262988:+","gi|397504618|ref|XP_003822882.1|",433,2e-44,"PREDICTED: uncharacterized protein LOC100981575 [Pan paniscus]","gi|551847162|tpe|HG494697.1|",4635,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000332156.1 (AC074093.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000204131",8,3,7,14.3528313187379,26,18,28,0.291834819851746,-1.77677606827825,0.00194177774869347,0.00602913863760459,"down","yes","NHSL2","protein_coding","chrX:71910818-72161750:+","gi|254692833|ref|NP_001013649.2|",5470,0,"NHS-like protein 2 [Homo sapiens]","gi|768037677|ref|XM_011530934.1|",13115,0,"PREDICTED: Homo sapiens NHS-like 2 (NHSL2), transcript variant X3, mRNA","Q5HYW2",1241,0,"NHS-like protein 2",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0030154|cell differentiation;",".",".",".","."]
["ENSG00000089685",1023,1016,903,2344.97964567346,3025,4019,5093,0.290348782057987,-1.78414111258634,9.75643966678643e-240,2.29490497918264e-237,"down","yes","BIRC5","protein_coding","chr17:78214186-78225636:+","gi|545687734|ref|NP_001270879.1|",755,7e-90,"baculoviral IAP repeat-containing protein 5 [Macaca fascicularis]","gi|59859881|ref|NM_001012271.1|",2700,0,"Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 3, mRNA","Q5RAH9",226,2e-67,"Baculoviral IAP repeat-containing protein 5",".",".",".",".","pfam00653","BIR","Inhibitor of Apoptosis domain. BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.","GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0051303|establishment of chromosome localization;GO:0000086|G2/M transition of mitotic cell cycle;GO:0000281|mitotic cytokinesis;GO:0007094|mitotic spindle assembly checkpoint;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0031536|positive regulation of exit from mitosis;GO:0045931|positive regulation of mitotic cell cycle;GO:0006468|protein phosphorylation;GO:0031503|protein complex localization;GO:0006351|transcription, DNA-templated;","GO:0005814|centriole;GO:0032133|chromosome passenger complex;GO:0000775|chromosome, centromeric region;GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0005881|cytoplasmic microtubule;GO:0005829|cytosol;GO:0031021|interphase microtubule organizing center;GO:0030496|midbody;GO:0005634|nucleus;GO:0005876|spindle microtubule;","GO:0048037|cofactor binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0008017|microtubule binding;GO:0042803|protein homodimerization activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;","K08731","BIRC5; baculoviral IAP repeat-containing protein 5"]
["ENSG00000115687",203,165,135,401.136619338579,509,741,823,0.288856301898657,-1.79157612498424,2.14066148084753e-52,6.49199349726214e-51,"down","yes","PASK","protein_coding","chr2:241106099-241150264:-","gi|355477269|ref|NP_001239053.1|",3514,0,"PAS domain-containing serine/threonine-protein kinase isoform 4 [Homo sapiens]","gi|5911968|emb|AL117400.1|",5165,0,"Homo sapiens mRNA; cDNA DKFZp434O051 (from clone DKFZp434O051)","Q96RG2",1293,0,"PAS domain-containing serine/threonine-protein kinase","SPAC1805.01c_2",60.5,7e-09,"COG0515","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0097009|energy homeostasis;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0045727|positive regulation of translation;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0070092|regulation of glucagon secretion;GO:0043576|regulation of respiratory gaseous exchange;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0035091|phosphatidylinositol binding;GO:0004674|protein serine/threonine kinase activity;","K08801","PASK; PAS domain containing serine/threonine kinase [EC:2.7.11.1]"]
["ENSG00000102466",5,4,6,12.1129169217278,20,19,22,0.288650153046553,-1.79260610460335,0.00310248784733357,0.009233264249247,"down","yes","FGF14","protein_coding","chr13:101710804-102402457:-","gi|28872756|ref|NP_787125.1|",1354,1e-166,"fibroblast growth factor 14 isoform 1B [Homo sapiens]","gi|11137671|emb|AL160153.11|",12166,0,"Human DNA sequence from clone RP11-397O8 on chromosome 13, complete sequence","Q92915",382,4e-118,"Fibroblast growth factor 14",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0007267|cell-cell signaling;GO:0007254|JNK cascade;GO:0007399|nervous system development;GO:1901843|positive regulation of high voltage-gated calcium channel activity;GO:0060078|regulation of postsynaptic membrane potential;GO:0048167|regulation of synaptic plasticity;GO:1903421|regulation of synaptic vesicle recycling;GO:0007165|signal transduction;","GO:0005576|extracellular region;GO:0005622|intracellular;GO:0005634|nucleus;","GO:0008083|growth factor activity;GO:0008201|heparin binding;",".","."]
["ENSG00000225872",8,1,10,15.3240258397666,19,39,19,0.288495149804781,-1.79338103047556,0.00327086140217357,0.00968950617802548,"down","yes","LINC01529","transcribed_unprocessed_pseudogene","chr19:35785697-35797902:-","gi|752408948|ref|XP_011225395.1|",607,5e-121,"PREDICTED: inactive serine/threonine-protein kinase TEX14 isoform X3 [Ailuropoda melanoleuca]","gi|2529398|gb|AC002398.1|AC002398",1205,0,"Human DNA from chromosome 19-specific cosmid F25965, genomic sequence, complete sequence","Q7M6U3",70.5,2e-13,"Inactive serine/threonine-protein kinase TEX14",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0008608|attachment of spindle microtubules to kinetochore;GO:0051301|cell division;GO:1990830|cellular response to leukemia inhibitory factor;GO:0043063|intercellular bridge organization;GO:0007140|male meiosis;GO:0051306|mitotic sister chromatid separation;GO:0007094|mitotic spindle assembly checkpoint;GO:0032466|negative regulation of cytokinesis;GO:0032091|negative regulation of protein binding;","GO:0005623|cell;GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0045171|intercellular bridge;GO:0000776|kinetochore;GO:0030496|midbody;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0019901|protein kinase binding;","K17540","TEX14, SGK307; inactive serine/threonine-protein kinase TEX14"]
["ENSG00000168496",1511,1517,1516,3649.99913499552,4915,6138,7794,0.288278814985221,-1.79446327483831,0,0,"down","yes","FEN1","protein_coding","chr11:61792637-61797244:+","gi|817279382|ref|XP_012309816.1|",1822,0,"PREDICTED: flap endonuclease 1 isoform X1 [Aotus nancymaae]","gi|332078486|ref|NM_004111.5|",2296,0,"Homo sapiens flap structure-specific endonuclease 1 (FEN1), mRNA","P39748",696,0,"Flap endonuclease 1","SPAC3G6.06c",423,4e-140,"COG0258","pfam00752","XPG_N","XPG N-terminal domain.","GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0043137|DNA replication, removal of RNA primer;GO:0006302|double-strand break repair;GO:0000724|double-strand break repair via homologous recombination;GO:0007613|memory;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0045876|positive regulation of sister chromatid cohesion;GO:0032201|telomere maintenance via semi-conservative replication;GO:0009650|UV protection;","GO:0016020|membrane;GO:0005739|mitochondrion;GO:0000784|nuclear chromosome, telomeric region;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0008409|5'-3' exonuclease activity;GO:0017108|5'-flap endonuclease activity;GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0008309|double-stranded DNA exodeoxyribonuclease activity;GO:0004519|endonuclease activity;GO:0004527|exonuclease activity;GO:0048256|flap endonuclease activity;GO:0046872|metal ion binding;GO:0004523|RNA-DNA hybrid ribonuclease activity;","K04799","FEN1, RAD2; flap endonuclease-1 [EC:3.-.-.-]"]
["ENSG00000166086",6,4,2,9.56001962668707,14,16,19,0.28786073629003,-1.79655707369238,0.00848305650237575,0.0229193435800285,"down","yes","JAM3","protein_coding","chr11:134068925-134152001:+","gi|18564959|emb|CAC94776.1|",1629,0,"junction adhesion molecule 3 [Homo sapiens]","gi|328927054|ref|NM_032801.4|",3668,0,"Homo sapiens junctional adhesion molecule 3 (JAM3), transcript variant 1, mRNA","Q9BX67",543,0,"Junctional adhesion molecule C",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002250|adaptive immune response;GO:0001525|angiogenesis;GO:0031103|axon regeneration;GO:0007160|cell-matrix adhesion;GO:0030010|establishment of cell polarity;GO:0030198|extracellular matrix organization;GO:0050900|leukocyte migration;GO:0002523|leukocyte migration involved in inflammatory response;GO:0042552|myelination;GO:0002318|myeloid progenitor cell differentiation;GO:0001780|neutrophil homeostasis;GO:0090138|regulation of actin cytoskeleton organization by cell-cell adhesion;GO:0090022|regulation of neutrophil chemotaxis;GO:0007286|spermatid development;GO:0019226|transmission of nerve impulse;","GO:0005923|bicellular tight junction;GO:0044291|cell-cell contact zone;GO:0030057|desmosome;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0033010|paranodal junction;GO:0005886|plasma membrane;GO:0043220|Schmidt-Lanterman incisure;","GO:0005178|integrin binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;","K06785","JAM3; junctional adhesion molecule 3"]
["ENSG00000197299",212,202,163,463.676897307434,592,830,982,0.286668073698511,-1.80254685470233,3.10443763916916e-66,1.190425311815e-64,"down","yes","BLM","protein_coding","chr15:90717327-90816165:+","gi|189054874|dbj|BAG36927.1|",6658,0,"unnamed protein product [Homo sapiens]","gi|564730685|ref|NM_000057.3|",4555,0,"Homo sapiens Bloom syndrome RecQ like helicase (BLM), transcript variant 1, mRNA","P54132",2547,0,"Bloom syndrome protein","SPAC2G11.12",447,7e-131,"COG0514","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0072757|cellular response to camptothecin;GO:0006974|cellular response to DNA damage stimulus;GO:0072711|cellular response to hydroxyurea;GO:0071479|cellular response to ionizing radiation;GO:0000729|DNA double-strand break processing;GO:0032508|DNA duplex unwinding;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0000724|double-strand break repair via homologous recombination;GO:0044806|G-quadruplex DNA unwinding;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0051782|negative regulation of cell division;GO:0045910|negative regulation of DNA recombination;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051259|protein oligomerization;GO:0051260|protein homooligomerization;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0090329|regulation of DNA-dependent DNA replication;GO:0031297|replication fork processing;GO:0048478|replication fork protection;GO:0010165|response to X-ray;GO:0090656|t-circle formation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000800|lateral element;GO:0000228|nuclear chromosome;GO:0016363|nuclear matrix;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;GO:0005657|replication fork;","GO:0036310|annealing helicase activity;GO:0005524|ATP binding;GO:0043140|ATP-dependent 3'-5' DNA helicase activity;GO:0004003|ATP-dependent DNA helicase activity;GO:0008026|ATP-dependent helicase activity;GO:0016887|ATPase activity;GO:0000405|bubble DNA binding;GO:0003677|DNA binding;GO:0003678|DNA helicase activity;GO:0008094|DNA-dependent ATPase activity;GO:0000400|four-way junction DNA binding;GO:0009378|four-way junction helicase activity;GO:0051880|G-quadruplex DNA binding;GO:0004386|helicase activity;GO:0002039|p53 binding;GO:0042803|protein homodimerization activity;GO:0003697|single-stranded DNA binding;GO:0000403|Y-form DNA binding;GO:0008270|zinc ion binding;","K10901","BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]"]
["ENSG00000247627",3,6,3,9.61025005901893,10,12,30,0.286412362766629,-1.80383432813306,0.0102103959476966,0.0270816992628125,"down","yes","MTND4P12","processed_pseudogene","chr5:134926660-134928036:-","gi|700283103|gb|AIU63865.1|",1367,0,"NADH dehydrogenase subunit 4 (mitochondrion) [Homo sapiens]","gi|338753425|ref|NG_029205.1|",1377,0,"Homo sapiens mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 12 (MTND4P12) on chromosome 5","P03905",528,0,"NADH-ubiquinone oxidoreductase chain 4","BMEI1146",156,4e-41,"COG1008","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0007568|aging;GO:0021549|cerebellum development;GO:0001701|in utero embryonic development;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0045471|response to ethanol;GO:0001666|response to hypoxia;GO:0035094|response to nicotine;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03881","ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:1.6.5.3]"]
["ENSG00000092853",351,365,361,870.709680773982,1200,1513,1767,0.286137952431464,-1.80521723003536,7.04575015857408e-122,6.20540771956972e-120,"down","yes","CLSPN","protein_coding","chr1:35720218-35769967:-","gi|694884908|ref|XP_009451927.1|",6132,0,"PREDICTED: claspin isoform X1 [Pan troglodytes]","gi|10944333|gb|AF297866.1|AF297866",4608,0,"Homo sapiens Hu-Claspin mRNA, complete cds","Q9HAW4",2210,0,"Claspin",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0032147|activation of protein kinase activity;GO:0000077|DNA damage checkpoint;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0033314|mitotic DNA replication checkpoint;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0018105|peptidyl-serine phosphorylation;GO:0016579|protein deubiquitination;","GO:0005794|Golgi apparatus;GO:0005654|nucleoplasm;","GO:0010997|anaphase-promoting complex binding;GO:0003677|DNA binding;",".","."]
["ENSG00000149596",10,8,9,21.798419324459,32,30,51,0.285621895441179,-1.80782151596289,6.82897468792102e-05,0.000265826970293886,"down","yes","JPH2","protein_coding","chr20:44111695-44187578:-","gi|21704281|ref|NP_065166.2|",2534,0,"junctophilin-2 isoform 1 [Homo sapiens]","gi|61699223|ref|NM_020433.4|",4785,0,"Homo sapiens junctophilin 2 (JPH2), transcript variant 1, mRNA","Q9BR39",980,0,"Junctophilin-2",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0055074|calcium ion homeostasis;GO:0060402|calcium ion transport into cytosol;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0055024|regulation of cardiac muscle tissue development;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;","GO:0016021|integral component of membrane;GO:0030314|junctional membrane complex;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0030018|Z disc;","GO:0015278|calcium-release channel activity;GO:0070300|phosphatidic acid binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0001786|phosphatidylserine binding;","K19530","JPH; junctophilin"]
["ENSG00000121152",581,526,526,1319.55386005729,1756,2288,2784,0.285419524647883,-1.80884406648851,3.23614357055754e-185,5.11628993351753e-183,"down","yes","NCAPH","protein_coding","chr2:96335787-96373845:+","gi|25121987|ref|NP_056156.2|",3622,0,"condensin complex subunit 2 isoform 1 [Homo sapiens]","gi|528281398|ref|NM_015341.4|",2675,0,"Homo sapiens non-SMC condensin I complex subunit H (NCAPH), transcript variant 1, mRNA","Q15003",1402,0,"Condensin complex subunit 2","SPCC306.03c",107,5e-23,"COG5229","pfam05786","Cnd2","Condensin complex subunit 2. This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localizes to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase. This family forms one of the three non-structural maintenance of chromosomes (SMC) subunits of the mitotic condensation complex along with Cnd1 and Cnd3.","GO:0051301|cell division;GO:0010032|meiotic chromosome condensation;GO:0045132|meiotic chromosome segregation;GO:0007076|mitotic chromosome condensation;","GO:0000796|condensin complex;GO:0005829|cytosol;GO:0016020|membrane;GO:0000799|nuclear condensin complex;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0072587|DNA topoisomerase (ATP-hydrolyzing) activator activity;GO:0044547|DNA topoisomerase binding;","K06676","BRRN1, BRN1, CAPH; condensin complex subunit 2"]
["ENSG00000101412",580,526,566,1359.80789290897,1903,2284,2830,0.283648636060159,-1.81782316813915,6.3557035558448e-185,9.96656993375078e-183,"down","yes","E2F1","protein_coding","chr20:33675683-33686404:-","gi|260574|gb|AAB24289.1|",1833,0,"transcription factor E2F like protein, partial [Homo sapiens]","gi|168480109|ref|NM_005225.2|",2503,0,"Homo sapiens E2F transcription factor 1 (E2F1), mRNA","Q01094",674,0,"Transcription factor E2F1",".",".",".",".","pfam02319","E2F_TDP","E2F/DP family winged-helix DNA-binding domain. This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.","GO:0043276|anoikis;GO:0071398|cellular response to fatty acid;GO:0071456|cellular response to hypoxia;GO:1990090|cellular response to nerve growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:0000077|DNA damage checkpoint;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0030900|forebrain development;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:1990086|lens fiber cell apoptotic process;GO:0048255|mRNA stabilization;GO:0043392|negative regulation of DNA binding;GO:0045599|negative regulation of fat cell differentiation;GO:0070345|negative regulation of fat cell proliferation;GO:0070317|negative regulation of G0 to G1 transition;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0071930|negative regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0043065|positive regulation of apoptotic process;GO:0048146|positive regulation of fibroblast proliferation;GO:0010628|positive regulation of gene expression;GO:1900740|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:2000045|regulation of G1/S transition of mitotic cell cycle;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0006355|regulation of transcription, DNA-templated;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0005813|centrosome;GO:0005739|mitochondrion;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0035189|Rb-E2F complex;","GO:0001047|core promoter binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0019901|protein kinase binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K17454","E2F1; transcription factor E2F1"]
["ENSG00000186185",970,980,927,2339.23045504267,3204,4002,4884,0.283626770597706,-1.8179343846449,1.75156405669049e-298,6.03288705811537e-296,"down","yes","KIF18B","protein_coding","chr17:44924709-44947711:-","gi|293338395|gb|ADE43428.1|",3985,0,"KIF18B [Homo sapiens]","gi|387942370|ref|NM_001264573.1|",4215,0,"Homo sapiens kinesin family member 18B (KIF18B), transcript variant 2, mRNA","Q86Y91",1499,0,"Kinesin-like protein KIF18B",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.","GO:0051301|cell division;GO:0007019|microtubule depolymerization;GO:0007018|microtubule-based movement;GO:0000278|mitotic cell cycle;GO:0000070|mitotic sister chromatid segregation;GO:0051302|regulation of cell division;","GO:0000235|astral microtubule;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:1990752|microtubule end;GO:0035371|microtubule plus-end;GO:0016604|nuclear body;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0019894|kinesin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0003774|motor activity;",".","."]
["ENSG00000122952",792,758,685,1817.6469483845,2468,3094,3854,0.283005927005873,-1.8210958270866,2.98980587985708e-251,8.00935775148381e-249,"down","yes","ZWINT","protein_coding","chr10:56357228-56361275:-","gi|14602427|ref|NP_127490.1|",866,6e-108,"ZW10 interactor isoform a [Homo sapiens]","gi|21752741|dbj|AK093808.1|",1955,0,"Homo sapiens cDNA FLJ36489 fis, clone THYMU2018126, highly similar to ZW10 interactor","O95229",338,2e-109,"ZW10 interactor",".",".",".",".","pfam15556","Zwint","ZW10 interactor. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.","GO:0051301|cell division;GO:0051649|establishment of localization in cell;GO:0007093|mitotic cell cycle checkpoint;GO:0000070|mitotic sister chromatid segregation;","GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0000776|kinetochore;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0047485|protein N-terminus binding;",".","."]
["ENSG00000225206",51,56,25,106.91445063076,150,178,225,0.2829408158336,-1.82142778611613,2.98572839160016e-16,2.95024227547049e-15,"down","yes","MIR137HG","lincRNA","chr1:97933474-98049863:-","gi|426330467|ref|XP_004026232.1|",641,3e-69,"PREDICTED: uncharacterized protein LOC101145987 [Gorilla gorilla gorilla]","gi|32400108|emb|BX005019.12|",2830,0,"Human DNA sequence from clone RP11-490G2 on chromosome 1, complete sequence","Q6UX73",58.9,1e-07,"UPF0764 protein C16orf89",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000116774",7,3,2,9.60396508277142,11,16,24,0.282595017795223,-1.82319206398368,0.00842370047632425,0.0227813144682196,"down","yes","OLFML3","protein_coding","chr1:113979391-114035572:+","gi|296208912|ref|XP_002751308.1|",1407,0,"PREDICTED: olfactomedin-like protein 3 [Callithrix jacchus]","gi|22761759|dbj|AK075544.1|",2051,0,"Homo sapiens cDNA PSEC0244 fis, clone NT2RP3000638","Q9NRN5",546,0,"Olfactomedin-like protein 3",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0007275|multicellular organismal development;","GO:1903561|extracellular vesicle;",".",".","."]
["ENSG00000176208",214,208,179,490.672113152363,730,883,889,0.282315150973953,-1.82462153907728,4.82427649945912e-62,1.73926439479565e-60,"down","yes","ATAD5","protein_coding","chr17:30831970-30895869:+","gi|26080431|ref|NP_079133.3|",9000,0,"ATPase family AAA domain-containing protein 5 [Homo sapiens]","gi|755571546|ref|NM_024857.4|",6869,0,"Homo sapiens ATPase family, AAA domain containing 5 (ATAD5), mRNA","Q96QE3",3459,0,"ATPase family AAA domain-containing protein 5",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006974|cellular response to DNA damage stimulus;GO:0002377|immunoglobulin production;GO:0030890|positive regulation of B cell proliferation;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:1901990|regulation of mitotic cell cycle phase transition;","GO:0005634|nucleus;","GO:0005524|ATP binding;",".","."]
["ENSG00000028137",3,4,4,8.94478148606449,7,19,22,0.281889344021199,-1.82679915269502,0.0109376274399018,0.028847296611857,"down","yes","TNFRSF1B","protein_coding","chr1:12167003-12209228:+","gi|4507577|ref|NP_001057.1|",2052,0,"tumor necrosis factor receptor superfamily member 1B precursor [Homo sapiens]","gi|23312365|ref|NM_001066.2|",3675,0,"Homo sapiens tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), mRNA","P20333",795,0,"Tumor necrosis factor receptor superfamily member 1B",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007568|aging;GO:0097190|apoptotic signaling pathway;GO:0071363|cellular response to growth factor stimulus;GO:0071222|cellular response to lipopolysaccharide;GO:0019221|cytokine-mediated signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0007275|multicellular organismal development;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050728|negative regulation of inflammatory response;GO:0043312|neutrophil degranulation;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0042127|regulation of cell proliferation;GO:0050779|RNA destabilization;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0035579|specific granule membrane;GO:0043196|varicosity;","GO:0005031|tumor necrosis factor-activated receptor activity;GO:0031625|ubiquitin protein ligase binding;","K05141","TNFRSF1B, TNFR2; tumor necrosis factor receptor superfamily member 1B"]
["ENSG00000131470",94,103,105,247.606898006575,369,400,503,0.281728327889476,-1.82762346035121,1.28398679575586e-38,2.87971364145803e-37,"down","yes","PSMC3IP","protein_coding","chr17:42572315-42577831:-","gi|119581250|gb|EAW60846.1|",1274,5e-172,"PSMC3 interacting protein, isoform CRA_a [Homo sapiens]","gi|364803810|ref|NM_016556.3|",1416,0,"Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA","Q9P2W1",419,2e-144,"Homologous-pairing protein 2 homolog",".",".",".",".","pfam07106","TBPIP","Tat binding protein 1(TBP-1)-interacting protein (TBPIP). This family consists of several eukaryotic TBP-1 interacting protein (TBPIP) sequences. TBP-1 has been demonstrated to interact with the human immunodeficiency virus type 1 (HIV-1) viral protein Tat, then modulate the essential replication process of HIV. In addition, TBP-1 has been shown to be a component of the 26S proteasome, a basic multiprotein complex that degrades ubiquitinated proteins in an ATP-dependent fashion. Human TBPIP interacts with human TBP-1 then modulates the inhibitory action of human TBP-1 on HIV-Tat-mediated transactivation.","GO:0007131|reciprocal meiotic recombination;","GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0030374|ligand-dependent nuclear receptor transcription coactivator activity;","K06695","PSMC3IP; 26S proteasome regulatory subunit, ATPase 3, interacting protein"]
["ENSG00000244468",5,2,3,8.11974777784192,10,17,15,0.281593419870738,-1.82831447266914,0.0139322766091714,0.0358731479425576,"down","yes","AC093001.1","antisense","chr3:149284782-149333653:+","gi|119584862|gb|EAW64458.1|",380,4e-43,"hCG2038441, partial [Homo sapiens]","gi|551851041|tpe|HG496166.1|",551,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000356331.1 (RP11-206M11.7 gene), antisense",".",".",".",".",".",".",".",".","pfam00475","IGPD","Imidazoleglycerol-phosphate dehydratase.",".",".",".",".","."]
["ENSG00000171241",623,491,523,1337.43810644857,1901,2242,2763,0.281340873978336,-1.82960892829208,2.93936515143031e-170,4.10829529281071e-168,"down","yes","SHCBP1","protein_coding","chr16:46580554-46621626:-","gi|296452958|sp|Q8NEM2.3|SHCBP_HUMAN",3453,0,"RecName: Full=SHC SH2 domain-binding protein 1","gi|426382070|ref|XM_004057596.1|",3391,0,"PREDICTED: Gorilla gorilla gorilla SHC SH2-domain binding protein 1 (SHCBP1), mRNA","Q8NEM2",1335,0,"SHC SH2 domain-binding protein 1",".",".",".",".","pfam13229","Beta_helix","Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.","GO:0008543|fibroblast growth factor receptor signaling pathway;GO:2000177|regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0030496|midbody;GO:0005819|spindle;","GO:0042169|SH2 domain binding;",".","."]
["ENSG00000188910",11,6,16,27.1800491090533,39,50,50,0.281287100000105,-1.82988470360204,1.42443489117008e-05,6.10815922207393e-05,"down","yes","GJB3","protein_coding","chr1:34781189-34786369:+","gi|13128960|ref|NP_076872.1|",1090,2e-140,"gap junction beta-3 protein [Homo sapiens]","gi|54607054|ref|NM_024009.2|",2217,0,"Homo sapiens gap junction protein beta 3 (GJB3), transcript variant 1, mRNA","O75712",424,6e-142,"Gap junction beta-3 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0007154|cell communication;GO:0071300|cellular response to retinoic acid;GO:0001701|in utero embryonic development;GO:0001890|placenta development;GO:0043588|skin development;GO:0007283|spermatogenesis;","GO:0030054|cell junction;GO:0005922|connexon complex;GO:0005737|cytoplasm;GO:0005921|gap junction;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005243|gap junction channel activity;","K07622","GJB3, CX31; gap junction protein, beta 3"]
["ENSG00000275966",8,5,10,18.8646019058707,27,28,43,0.281148376495772,-1.83059637889344,0.000198461851724882,0.000725124492530691,"down","yes","AC110285.6","lincRNA","chr17:81345476-81345966:-","gi|694970192|ref|XP_009431789.1|",448,5e-52,"PREDICTED: uncharacterized protein-like [Pan troglodytes]","gi|666672068|tpe|LK938165.1|",491,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473669.1 (RP11-1055B8.9 gene), lincRNA",".",".",".",".",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.",".",".",".",".","."]
["ENSG00000136943",25,18,30,59.9455208277018,92,82,136,0.281030842124126,-1.83119962516069,2.37550870777049e-10,1.62535693350398e-09,"down","yes","CTSV","protein_coding","chr9:97029679-97039643:-","gi|297684916|ref|XP_002820055.1|",1825,0,"PREDICTED: cathepsin L2 isoform X1 [Pongo abelii]","gi|320118897|ref|NM_001201575.1|",4322,0,"Homo sapiens cathepsin V (CTSV), transcript variant 2, mRNA","O60911",700,0,"Cathepsin L2","AF1946_2",81.3,1e-15,"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0048102|autophagic cell death;GO:0009267|cellular response to starvation;GO:0046697|decidualization;GO:0022617|extracellular matrix disassembly;GO:0031069|hair follicle morphogenesis;GO:0010259|multicellular organismal aging;GO:0010839|negative regulation of keratinocyte proliferation;GO:0021675|nerve development;GO:0016540|protein autoprocessing;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:2000249|regulation of actin cytoskeleton reorganization;GO:0045616|regulation of keratinocyte differentiation;GO:0051384|response to glucocorticoid;GO:0009749|response to glucose;GO:0034698|response to gonadotropin;GO:1990834|response to odorant;GO:0060008|Sertoli cell differentiation;GO:0007283|spermatogenesis;","GO:0045177|apical part of cell;GO:0009897|external side of plasma membrane;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043202|lysosomal lumen;GO:0005764|lysosome;GO:0005902|microvillus;GO:0043005|neuron projection;GO:0005730|nucleolus;GO:0043204|perikaryon;GO:0030141|secretory granule;","GO:0004177|aminopeptidase activity;GO:0016807|cysteine-type carboxypeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0042393|histone binding;GO:0030984|kininogen binding;GO:0042277|peptide binding;GO:0044877|macromolecular complex binding;GO:0004252|serine-type endopeptidase activity;","K01375","CTSL2, CTSV; cathepsin V [EC:3.4.22.43]"]
["ENSG00000147536",136,131,116,313.262241518101,427,521,680,0.280794085187715,-1.83241554870438,1.39010041783668e-51,4.15693904794323e-50,"down","yes","GINS4","protein_coding","chr8:41529206-41545046:+","gi|14150122|ref|NP_115712.1|",920,2e-111,"DNA replication complex GINS protein SLD5 [Homo sapiens]","gi|19848415|gb|AC009630.14|",3227,0,"Homo sapiens chromosome 8, clone RP11-360L9, complete sequence","Q9BRT9",358,8e-113,"DNA replication complex GINS protein SLD5","SPBP4H10.21c",58.2,2e-08,"COG5086","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0032508|DNA duplex unwinding;GO:0006270|DNA replication initiation;GO:0006271|DNA strand elongation involved in DNA replication;GO:0000727|double-strand break repair via break-induced replication;GO:0001833|inner cell mass cell proliferation;","GO:0005737|cytoplasm;GO:0000811|GINS complex;GO:0005654|nucleoplasm;GO:0031298|replication fork protection complex;",".","K10735","GINS4, SLD5; GINS complex subunit 4"]
["ENSG00000165480",293,250,244,644.853480480073,912,1100,1319,0.280416696543446,-1.83435584217473,2.45988126905577e-100,1.6304532617714e-98,"down","yes","SKA3","protein_coding","chr13:21153595-21176602:-","gi|260763910|ref|NP_659498.4|",2161,0,"spindle and kinetochore-associated protein 3 isoform 1 [Homo sapiens]","gi|260763909|ref|NM_145061.5|",2919,0,"Homo sapiens spindle and kinetochore associated complex subunit 3 (SKA3), transcript variant 1, mRNA","Q8IX90",837,0,"Spindle and kinetochore-associated protein 3",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.","GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0000278|mitotic cell cycle;GO:0031110|regulation of microtubule polymerization or depolymerization;","GO:0000940|condensed chromosome outer kinetochore;GO:0005737|cytoplasm;GO:0000776|kinetochore;GO:0005876|spindle microtubule;",".",".","."]
["ENSG00000142185",1,2,7,8.31673050586518,9,10,26,0.279946168075107,-1.83677866242308,0.0197034563869781,0.0485302345539564,"down","yes","TRPM2","protein_coding","chr21:44350163-44443081:+","gi|530419343|ref|XP_005261228.1|",7430,0,"PREDICTED: transient receptor potential cation channel subfamily M member 2 isoform X1 [Homo sapiens]","gi|3928755|dbj|AB001535.1|",6190,0,"Homo sapiens mRNA, complete cds","O94759",2862,0,"Transient receptor potential cation channel subfamily M member 2",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0098703|calcium ion import across plasma membrane;GO:0097553|calcium ion transmembrane import into cytosol;GO:0070588|calcium ion transmembrane transport;GO:0006816|calcium ion transport;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0071277|cellular response to calcium ion;GO:0070301|cellular response to hydrogen peroxide;GO:0071415|cellular response to purine-containing compound;GO:0071502|cellular response to temperature stimulus;GO:0002407|dendritic cell chemotaxis;GO:0097028|dendritic cell differentiation;GO:0043312|neutrophil degranulation;GO:2000249|regulation of actin cytoskeleton reorganization;GO:0051489|regulation of filopodium assembly;GO:0051209|release of sequestered calcium ion into cytosol;GO:0014074|response to purine-containing compound;GO:0001659|temperature homeostasis;GO:0071577|zinc II ion transmembrane transport;","GO:0042995|cell projection;GO:0030659|cytoplasmic vesicle membrane;GO:0005887|integral component of plasma membrane;GO:0005765|lysosomal membrane;GO:0005764|lysosome;GO:0043204|perikaryon;GO:0005886|plasma membrane;GO:0035579|specific granule membrane;GO:0070821|tertiary granule membrane;","GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;GO:0015278|calcium-release channel activity;GO:0005261|cation channel activity;GO:0005272|sodium channel activity;","K04977","TRPM2; transient receptor potential cation channel subfamily M member 2"]
["ENSG00000257446",2,5,2,7.42907672515921,12,11,15,0.279867889430895,-1.83718212571963,0.0187424793452927,0.0464301235052667,"down","yes","ZNF878","protein_coding","chr19:12043805-12052939:-","gi|768003837|ref|XP_011526555.1|",2807,0,"PREDICTED: zinc finger protein 878 isoform X1 [Homo sapiens]","gi|332634995|ref|NM_001080404.2|",1734,0,"Homo sapiens zinc finger protein 878 (ZNF878), mRNA","C9JN71",1085,0,"Zinc finger protein 878",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0003676|nucleic acid binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSG00000082497",69,78,75,183.296232897443,231,357,364,0.27844295561372,-1.84454630083282,1.55262180233106e-28,2.62462483114474e-27,"down","yes","SERTAD4","protein_coding","chr1:210232799-210246631:+","gi|10092667|ref|NP_062551.1|",1646,0,"SERTA domain-containing protein 4 [Homo sapiens]","gi|426333667|ref|XM_004028345.1|",4918,0,"PREDICTED: Gorilla gorilla gorilla SERTA domain containing 4, transcript variant 1 (SERTAD4), mRNA","Q9NUC0",638,0,"SERTA domain-containing protein 4",".",".",".",".","pfam06031","SERTA","SERTA motif. This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.",".","GO:0005634|nucleus;",".",".","."]
["ENSG00000269974",8,6,3,14.0201111230689,27,16,28,0.277308612467663,-1.85043567154481,0.00165238339252982,0.00519921221453756,"down","yes","AC091057.4","lincRNA","chr15:30648797-30649529:+",".",".",".",".","gi|595077219|gb|AC254951.1|",733,0,"Homo sapiens chromosome 15 clone VMRC53-242D11, complete sequence",".",".",".",".",".",".",".",".","pfam13942","Lipoprotein_20","YfhG lipoprotein. This family includes the YfhG protein from Escherichia coli. Members of this family have an N-terminal lipoprotein attachment site. The members of this family are functionally uncharacterized.",".",".",".",".","."]
["ENSG00000165244",313,293,300,750.573012556649,1065,1205,1633,0.276849506973559,-1.852826142235,8.91663212172304e-110,6.6646023511546e-108,"down","yes","ZNF367","protein_coding","chr9:96385941-96418329:-","gi|24233572|ref|NP_710162.1|",1343,2e-171,"zinc finger protein 367 [Homo sapiens]","gi|215422377|ref|NM_153695.3|",3646,0,"Homo sapiens zinc finger protein 367 (ZNF367), mRNA","Q7RTV3",521,7e-173,"Zinc finger protein 367",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000185585",68,68,68,169.396140767953,216,311,358,0.275803056441074,-1.85828965004436,5.24390825350727e-29,8.94292682525625e-28,"down","yes","OLFML2A","protein_coding","chr9:124777158-124814885:+","gi|116014339|ref|NP_872293.2|",3125,0,"olfactomedin-like protein 2A isoform 1 precursor [Homo sapiens]","gi|544186072|ref|NM_182487.3|",6425,0,"Homo sapiens olfactomedin like 2A (OLFML2A), transcript variant 1, mRNA","Q68BL7",1208,0,"Olfactomedin-like protein 2A",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;","GO:0050840|extracellular matrix binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000111665",435,423,358,1011.85459165679,1370,1704,2216,0.27453094498604,-1.86495931665262,2.51873940898621e-146,2.76030941593897e-144,"down","yes","CDCA3","protein_coding","chr12:6844793-6852066:-","gi|767971308|ref|XP_011519256.1|",591,6e-65,"PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [Homo sapiens]","gi|21752737|dbj|AK093805.1|",2839,0,"Homo sapiens cDNA FLJ36486 fis, clone THYMU2017831","P16520",154,5e-39,"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0006457|protein folding;GO:0008217|regulation of blood pressure;","GO:0044297|cell body;GO:0005829|cytosol;GO:0030425|dendrite;GO:0070062|extracellular exosome;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0051020|GTPase binding;GO:0030507|spectrin binding;","K07825","GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3"]
["ENSG00000149571",16,14,12,35.1163124851773,58,53,69,0.274000592754631,-1.86774908066783,2.53021738322017e-07,1.30768576869107e-06,"down","yes","KIRREL3","protein_coding","chr11:126423359-127003460:-","gi|26006461|ref|NP_115920.1|",3916,0,"kin of IRRE-like protein 3 isoform 1 precursor [Homo sapiens]","gi|14017950|dbj|AB058770.1|",3790,0,"Homo sapiens KIAA1867 mRNA for KIAA1867 protein","Q8IZU9",1483,0,"Kin of IRRE-like protein 3",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0072102|glomerulus morphogenesis;GO:0030097|hemopoiesis;GO:0021766|hippocampus development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0002121|inter-male aggressive behavior;GO:0001764|neuron migration;GO:0048812|neuron projection morphogenesis;GO:0021740|principal sensory nucleus of trigeminal nerve development;GO:0007416|synapse assembly;","GO:0030424|axon;GO:0030425|dendrite;GO:0043198|dendritic shaft;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000154146",88,70,70,189.775476868114,242,339,415,0.273870668523596,-1.86843333282912,2.66726765444121e-32,5.09873721693381e-31,"down","yes","NRGN","protein_coding","chr11:124739846-124747210:+","gi|817310108|ref|XP_012325636.1|",256,4e-32,"PREDICTED: neurogranin isoform X1 [Aotus nancymaae]","gi|187131237|ref|NM_006176.2|",1215,0,"Homo sapiens neurogranin (NRGN), transcript variant 1, mRNA","Q92686",57.4,7e-09,"Neurogranin",".",".",".",".","pfam00612","IQ","IQ calmodulin-binding motif. Calmodulin-binding motif.","GO:0008306|associative learning;GO:0007399|nervous system development;GO:1900273|positive regulation of long-term synaptic potentiation;GO:0007165|signal transduction;GO:0021537|telencephalon development;","GO:0030424|axon;GO:0044327|dendritic spine head;GO:0031966|mitochondrial membrane;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0014069|postsynaptic density;GO:0012510|trans-Golgi network transport vesicle membrane;","GO:0005516|calmodulin binding;GO:0070300|phosphatidic acid binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;",".","."]
["ENSG00000186897",21,24,10,45.6469018237619,57,79,105,0.27347376871685,-1.8705256368495,1.12908362541697e-08,6.64766940385912e-08,"down","yes","C1QL4","protein_coding","chr12:49332411-49337188:-","gi|961722133|ref|XP_014921323.1|",826,3e-102,"PREDICTED: complement C1q-like protein 4, partial [Acinonyx jubatus]","gi|56606141|ref|NM_001008223.1|",2065,0,"Homo sapiens complement component 1, q subcomponent-like 4 (C1QL4), mRNA","Q86Z23",319,2e-102,"Complement C1q-like protein 4",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0045599|negative regulation of fat cell differentiation;GO:0048147|negative regulation of fibroblast proliferation;","GO:0005581|collagen trimer;GO:0005615|extracellular space;","GO:0042802|identical protein binding;",".","."]
["ENSG00000197275",25,10,17,43.3799665744643,71,65,87,0.273469017675581,-1.87055070091049,3.99245478652768e-08,2.2385601140275e-07,"down","yes","RAD54B","protein_coding","chr8:94371960-94475109:-","gi|6912622|ref|NP_036547.1|",4770,0,"DNA repair and recombination protein RAD54B isoform 1 [Homo sapiens]","gi|327532736|ref|NM_012415.3|",3068,0,"Homo sapiens RAD54 homolog B (S. cerevisiae) (RAD54B), transcript variant 1, mRNA","Q9Y620",1842,0,"DNA repair and recombination protein RAD54B","SPAC15A10.03c",482,2e-153,"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0000724|double-strand break repair via homologous recombination;GO:0006312|mitotic recombination;GO:0007131|reciprocal meiotic recombination;","GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003678|DNA helicase activity;GO:0015616|DNA translocase activity;GO:0003724|RNA helicase activity;","K10877","RAD54B; DNA repair and recombination protein RAD54B [EC:3.6.4.-]"]
["ENSG00000073111",671,595,548,1520.9965846971,2121,2558,3263,0.271978790959224,-1.87843394109906,1.01602358343188e-220,2.13011553013413e-218,"down","yes","MCM2","protein_coding","chr3:127598223-127622436:+","gi|33356547|ref|NP_004517.2|",4371,0,"DNA replication licensing factor MCM2 [Homo sapiens]","gi|409971406|ref|NM_004526.3|",3488,0,"Homo sapiens minichromosome maintenance complex component 2 (MCM2), transcript variant 1, mRNA","P49736",1688,0,"DNA replication licensing factor MCM2","SPBC4.04c",783,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0006915|apoptotic process;GO:0071353|cellular response to interleukin-4;GO:0090102|cochlea development;GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0006268|DNA unwinding involved in DNA replication;GO:0000082|G1/S transition of mitotic cell cycle;GO:0006334|nucleosome assembly;","GO:0000785|chromatin;GO:0005737|cytoplasm;GO:0042555|MCM complex;GO:0015630|microtubule cytoskeleton;GO:0000784|nuclear chromosome, telomeric region;GO:0005664|nuclear origin of replication recognition complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003688|DNA replication origin binding;GO:0019899|enzyme binding;GO:0004386|helicase activity;GO:0042393|histone binding;GO:0046872|metal ion binding;","K02540","MCM2; DNA replication licensing factor MCM2 [EC:3.6.4.12]"]
["ENSG00000100162",149,145,123,350.381287152824,489,564,783,0.27120352713969,-1.88255215330894,4.26729989575328e-57,1.41422131253074e-55,"down","yes","CENPM","protein_coding","chr22:41938721-41947164:-","gi|795129887|ref|XP_011834141.1|",763,4e-98,"PREDICTED: centromere protein M isoform X1 [Mandrillus leucophaeus]","gi|749502322|ref|NM_001304370.1|",1002,0,"Homo sapiens centromere protein M (CENPM), transcript variant 4, mRNA","Q9NSP4",297,4e-99,"Centromere protein M",".",".",".",".","pfam11111","CENP-M","Centromere protein M (CENP-M). The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.","GO:0034080|CENP-A containing nucleosome assembly;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0005654|nucleoplasm;",".","K11505","CENPM; centromere protein M"]
["ENSG00000133083",41,50,45,114.804068392137,166,191,240,0.271119019360472,-1.88300177118217,7.2471531613844e-21,8.96045449851169e-20,"down","yes","DCLK1","protein_coding","chr13:35768652-36131306:-","gi|635024940|ref|XP_007958307.1|",3709,0,"PREDICTED: serine/threonine-protein kinase DCLK1 isoform X2 [Chlorocebus sabaeus]","gi|767978253|ref|XM_005266592.2|",7985,0,"PREDICTED: Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant X1, mRNA","O15075",1404,0,"Serine/threonine-protein kinase DCLK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0048675|axon extension;GO:0007417|central nervous system development;GO:0021952|central nervous system projection neuron axonogenesis;GO:0048813|dendrite morphogenesis;GO:0016197|endosomal transport;GO:0030900|forebrain development;GO:0035556|intracellular signal transduction;GO:1900181|negative regulation of protein localization to nucleus;GO:0007399|nervous system development;GO:0001764|neuron migration;GO:0048812|neuron projection morphogenesis;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0006468|protein phosphorylation;GO:0009615|response to virus;","GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0014069|postsynaptic density;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K08805","DCLK1_2; doublecortin-like kinase 1/2 [EC:2.7.11.1]"]
["ENSG00000175643",64,83,93,203.244810291573,283,333,447,0.270754117223006,-1.88494481854203,3.65639285529529e-31,6.72943753749385e-30,"down","yes","RMI2","protein_coding","chr16:11249619-11381662:+","gi|71297173|gb|AAH39361.1|",445,2e-49,"C16orf75 protein [Homo sapiens]","gi|25058672|gb|BC039361.1|",1862,0,"Homo sapiens chromosome 16 open reading frame 75, mRNA (cDNA clone MGC:43647 IMAGE:5270594), complete cds","Q96E14",107,3e-25,"RecQ-mediated genome instability protein 2",".",".",".",".","pfam15280","BORA_N","Protein aurora borealis N-terminus. This family of proteins is required for the activation of the protein kinase Aurora-A.","GO:0006260|DNA replication;GO:0033045|regulation of sister chromatid segregation;","GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;","K15365","RMI2; RecQ-mediated genome instability protein 2"]
["ENSG00000163040",32,20,23,63.5470487690144,101,120,103,0.26917813143602,-1.89336688757787,2.85091255892394e-11,2.1003973046801e-10,"down","yes","CCDC74A","protein_coding","chr2:131527675-131533666:+","gi|20270307|ref|NP_620125.1|",1752,0,"coiled-coil domain-containing protein 74A isoform 1 [Homo sapiens]","gi|385198098|ref|NM_138770.2|",1542,0,"Homo sapiens coiled-coil domain containing 74A (CCDC74A), transcript variant 1, mRNA",".",".",".",".",".",".",".",".","pfam14917","CCDC74_C","Coiled coil protein 74, C terminal. This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.",".",".",".",".","."]
["ENSG00000169247",138,98,119,301.328749836932,436,513,621,0.268157130251351,-1.89884948000617,3.04100531193127e-49,8.70250896981161e-48,"down","yes","SH3TC2","protein_coding","chr5:148923639-149063163:-","gi|119582199|gb|EAW61795.1|",4551,0,"hCG1979865, isoform CRA_a [Homo sapiens]","gi|18916897|dbj|AB075865.1|",7280,0,"Homo sapiens mRNA for KIAA1985 protein","Q8TF17",1753,0,"SH3 domain and tetratricopeptide repeat-containing protein 2","sll0499_1",62.4,1e-08,"COG0457","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0032287|peripheral nervous system myelin maintenance;GO:1901184|regulation of ERBB signaling pathway;GO:0033157|regulation of intracellular protein transport;","GO:0005886|plasma membrane;GO:0055037|recycling endosome;",".",".","."]
["ENSG00000143476",271,268,223,647.842473635466,901,1084,1415,0.267263942045862,-1.90366288559162,6.3146488569125e-104,4.34989096971887e-102,"down","yes","DTL","protein_coding","chr1:212035553-212107400:+","gi|302393825|sp|Q9NZJ0.3|DTL_HUMAN",3527,0,"RecName: Full=Denticleless protein homolog; AltName: Full=DDB1- and CUL4-associated factor 2; AltName: Full=Lethal(2) denticleless protein homolog; AltName: Full=Retinoic acid-regulated nuclear matrix-associated protein","gi|555943896|ref|NM_016448.3|",4567,0,"Homo sapiens denticleless E3 ubiquitin protein ligase homolog (DTL), transcript variant 1, mRNA","Q9NZJ0",1360,0,"Denticleless protein homolog",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0006974|cellular response to DNA damage stimulus;GO:0042769|DNA damage response, detection of DNA damage;GO:0006260|DNA replication;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0045732|positive regulation of protein catabolic process;GO:0043687|post-translational protein modification;GO:0006513|protein monoubiquitination;GO:0000209|protein polyubiquitination;GO:0051726|regulation of cell cycle;GO:0009411|response to UV;GO:0072425|signal transduction involved in G2 DNA damage checkpoint;GO:0019985|translesion synthesis;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005813|centrosome;GO:0005694|chromosome;GO:0080008|Cul4-RING E3 ubiquitin ligase complex;GO:0031464|Cul4A-RING E3 ubiquitin ligase complex;GO:0031465|Cul4B-RING E3 ubiquitin ligase complex;GO:0005829|cytosol;GO:0031965|nuclear membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K11790","DTL, CDT2, DCAF2; denticleless"]
["ENSG00000105894",65,74,57,167.282025628383,254,278,336,0.267011468097787,-1.90502638813371,3.5891435581772e-29,6.15354675112195e-28,"down","yes","PTN","protein_coding","chr7:137227341-137343865:-","gi|953851560|ref|XP_014594832.1|",687,5e-83,"PREDICTED: pleiotrophin, partial [Equus caballus]","gi|530386264|ref|XM_005250516.1|",1598,0,"PREDICTED: Homo sapiens pleiotrophin (PTN), transcript variant X2, mRNA","P63090",221,2e-67,"Pleiotrophin",".",".",".",".","pfam01091","PTN_MK_C","PTN/MK heparin-binding protein family, C-terminal domain.","GO:0030282|bone mineralization;GO:0007420|brain development;GO:0071456|cellular response to hypoxia;GO:0071407|cellular response to organic cyclic compound;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0034644|cellular response to UV;GO:0071305|cellular response to vitamin D;GO:0021549|cerebellum development;GO:0045446|endothelial cell differentiation;GO:0044849|estrous cycle;GO:0007507|heart development;GO:0030902|hindbrain development;GO:0007612|learning;GO:0001889|liver development;GO:0060291|long-term synaptic potentiation;GO:0030324|lung development;GO:0016525|negative regulation of angiogenesis;GO:0030336|negative regulation of cell migration;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060253|negative regulation of glial cell proliferation;GO:0045837|negative regulation of membrane potential;GO:0072201|negative regulation of mesenchymal cell proliferation;GO:1904397|negative regulation of neuromuscular junction development;GO:0043065|positive regulation of apoptotic process;GO:0051781|positive regulation of cell division;GO:0010811|positive regulation of cell-substrate adhesion;GO:2000347|positive regulation of hepatocyte proliferation;GO:0010976|positive regulation of neuron projection development;GO:1904395|positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0008360|regulation of cell shape;GO:0014823|response to activity;GO:1904391|response to ciliary neurotrophic factor;GO:0042493|response to drug;GO:0032355|response to estradiol;GO:1904373|response to kainic acid;GO:1990089|response to nerve growth factor;GO:0032570|response to progesterone;GO:0060041|retina development in camera-type eye;GO:0060221|retinal rod cell differentiation;GO:1904389|rod bipolar cell differentiation;GO:0021510|spinal cord development;GO:0021794|thalamus development;","GO:0005604|basement membrane;GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016020|membrane;GO:0031594|neuromuscular junction;GO:0048471|perinuclear region of cytoplasm;GO:0032991|macromolecular complex;","GO:0035374|chondroitin sulfate binding;GO:0035373|chondroitin sulfate proteoglycan binding;GO:0005539|glycosaminoglycan binding;GO:0008083|growth factor activity;GO:1904399|heparan sulfate binding;GO:0008201|heparin binding;GO:0019901|protein kinase binding;GO:0043394|proteoglycan binding;GO:0038085|vascular endothelial growth factor binding;","K16642","PTN; pleiotrophin"]
["ENSG00000128510",4,6,10,17.571548479398,34,19,37,0.261990202856275,-1.93241523180761,0.000385926561189118,0.00134997307076817,"down","yes","CPA4","protein_coding","chr7:130293134-130324180:+","gi|61743916|ref|NP_057436.2|",2275,0,"carboxypeptidase A4 preproprotein [Homo sapiens]","gi|223941942|ref|NM_016352.3|",2814,0,"Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 1, mRNA","Q9UI42",880,0,"Carboxypeptidase A4","YHR132c",194,4e-53,"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0016573|histone acetylation;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K08637","CPA4; carboxypeptidase A4 [EC:3.4.17.-]"]
["ENSG00000154556",19,13,23,48.209269255183,62,83,112,0.257733784060598,-1.95604643505851,6.12230286268495e-10,4.05379257176338e-09,"down","yes","SORBS2","protein_coding","chr4:185585444-185956652:-","gi|398650630|ref|NP_001257700.1|",5645,0,"sorbin and SH3 domain-containing protein 2 isoform 9 [Homo sapiens]","gi|194733751|ref|NM_021069.4|",5996,0,"Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 2, mRNA","O94875",2049,0,"Sorbin and SH3 domain-containing protein 2",".",".",".",".","pfam02208","Sorb","Sorbin homologous domain.","GO:0007015|actin filament organization;GO:0061049|cell growth involved in cardiac muscle cell development;","GO:0015629|actin cytoskeleton;GO:0016324|apical plasma membrane;GO:0005925|focal adhesion;GO:0030027|lamellipodium;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0030018|Z disc;","GO:0008093|cytoskeletal adaptor activity;GO:0003723|RNA binding;GO:0005200|structural constituent of cytoskeleton;GO:0008307|structural constituent of muscle;",".","."]
["ENSG00000186871",259,238,271,675.168016906966,949,1237,1361,0.257293245344823,-1.95851451203034,4.25101887515868e-103,2.90757631432839e-101,"down","yes","ERCC6L","protein_coding","chrX:72204657-72239047:-","gi|58331268|ref|NP_060139.2|",6279,0,"DNA excision repair protein ERCC-6-like [Homo sapiens]","gi|16551910|dbj|AK056494.1|",4316,0,"Homo sapiens cDNA FLJ31932 fis, clone NT2RP7006296, weakly similar to EXCISION REPAIR PROTEIN ERCC-6","Q2NKX8",2420,0,"DNA excision repair protein ERCC-6-like","ECU09g0410",309,2e-89,"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0015616|DNA translocase activity;GO:0004386|helicase activity;",".","."]
["ENSG00000265763",48,61,59,148.957479943731,216,248,322,0.255028440987672,-1.97126994825874,1.25867943223744e-27,2.07145127039212e-26,"down","yes","ZNF488","protein_coding","chr10:47365496-47384273:-","gi|23308499|ref|NP_694579.1|",1518,0,"zinc finger protein 488 [Homo sapiens]","gi|40255102|ref|NM_153034.2|",3496,0,"Homo sapiens zinc finger protein 488 (ZNF488), mRNA","Q96MN9",589,0,"Zinc finger protein 488",".",".",".",".","pfam00096","zf-C2H2","Zinc finger, C2H2 type. The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.","GO:0045892|negative regulation of transcription, DNA-templated;GO:0014003|oligodendrocyte development;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000234498",16,19,19,47.8899913986451,66,91,95,0.254907584448514,-1.97195379534649,2.63593431382246e-10,1.79463116996144e-09,"down","yes","RPL13AP20","processed_pseudogene","chr12:12875499-12876107:+","gi|119616692|gb|EAW96286.1|",1068,4e-146,"hCG27695, isoform CRA_a [Homo sapiens]","gi|219881533|ref|NR_003932.2|",609,0,"Homo sapiens ribosomal protein L13a pseudogene 20 (RPL13AP20), non-coding RNA","P40429",378,8e-133,"60S ribosomal protein L13a","SPBC839.13c",217,4e-70,"COG0102","pfam00572","Ribosomal_L13","Ribosomal protein L13.","GO:0071346|cellular response to interferon-gamma;GO:1901194|negative regulation of formation of translation preinitiation complex;GO:0017148|negative regulation of translation;GO:0000184|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614|SRP-dependent cotranslational protein targeting to membrane;GO:0006412|translation;GO:0006413|translational initiation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0022625|cytosolic large ribosomal subunit;GO:0005925|focal adhesion;GO:0097452|GAIT complex;GO:0015934|large ribosomal subunit;GO:0016020|membrane;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0003729|mRNA binding;GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;","K02872","RP-L13Ae, RPL13A; large subunit ribosomal protein L13Ae"]
["ENSG00000126803",124,131,105,318.60821198422,481,544,646,0.254827177720706,-1.97240894338439,1.19333423746269e-55,3.88145544218892e-54,"down","yes","HSPA2","protein_coding","chr14:64535905-64546173:+","gi|13676857|ref|NP_068814.2|",3063,0,"heat shock-related 70 kDa protein 2 [Homo sapiens]","gi|13872723|emb|AL049869.6|",5329,0,"Human chromosome 14 DNA sequence BAC R-973N13 of library RPCI-11 from chromosome 14 of Homo sapiens (Human), complete sequence","P54652",1184,0,"Heat shock-related 70 kDa protein 2",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0007141|male meiosis I;GO:0007140|male meiosis;GO:0090084|negative regulation of inclusion body assembly;GO:1901896|positive regulation of calcium-transporting ATPase activity;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0001934|positive regulation of protein phosphorylation;GO:0042026|protein refolding;GO:0009409|response to cold;GO:0009408|response to heat;GO:0006986|response to unfolded protein;GO:0007286|spermatid development;GO:0007283|spermatogenesis;GO:0070194|synaptonemal complex disassembly;","GO:0072562|blood microparticle;GO:0036128|CatSper complex;GO:0009986|cell surface;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0001673|male germ cell nucleus;GO:0072687|meiotic spindle;GO:0016020|membrane;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0000795|synaptonemal complex;","GO:0005524|ATP binding;GO:0051087|chaperone binding;GO:0019899|enzyme binding;GO:0051861|glycolipid binding;GO:0048156|tau protein binding;GO:0051082|unfolded protein binding;","K03283","HSPA1_8; heat shock 70kDa protein 1/8"]
["ENSG00000146670",895,845,807,2258.9757655774,3220,3883,4842,0.253814619040984,-1.97815292795211,0,0,"down","yes","CDCA5","protein_coding","chr11:65066300-65084164:-","gi|18087845|ref|NP_542399.1|",1027,9e-130,"sororin [Homo sapiens]","gi|188497628|ref|NM_080668.3|",2576,0,"Homo sapiens cell division cycle associated 5 (CDCA5), mRNA","Q96FF9",400,3e-131,"Sororin",".",".",".",".","pfam09666","Sororin","Sororin protein. Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion. The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex.","GO:0051301|cell division;GO:0006302|double-strand break repair;GO:0000278|mitotic cell cycle;GO:0007076|mitotic chromosome condensation;GO:0007080|mitotic metaphase plate congression;GO:0007064|mitotic sister chromatid cohesion;GO:0031536|positive regulation of exit from mitosis;GO:0071922|regulation of cohesin localization to chromatin;","GO:0005694|chromosome;GO:0000775|chromosome, centromeric region;GO:0008278|cohesin complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;","K17390","CDCA5; sororin"]
["ENSG00000198542",55,54,37,130.322625408853,195,214,280,0.2511916831634,-1.99313939681049,6.09366079784068e-25,8.93798703184419e-24,"down","yes","ITGBL1","protein_coding","chr13:101452593-101720856:+","gi|418203907|ref|NP_001258685.1|",1597,0,"integrin beta-like protein 1 isoform 3 [Homo sapiens]","gi|418203908|ref|NM_001271754.1|",4808,0,"Homo sapiens integrin subunit beta like 1 (ITGBL1), transcript variant 4, mRNA","O95965",619,0,"Integrin beta-like protein 1",".",".",".",".","pfam07974","EGF_2","EGF-like domain. This family contains EGF domains found in a variety of extracellular proteins.","GO:0007155|cell adhesion;","GO:0005576|extracellular region;GO:0005886|plasma membrane;",".",".","."]
["ENSG00000153923",2,4,2,7.20405101951757,10,14,14,0.249917749872305,-2.0004747255021,0.0123859284680862,0.0322837551746551,"down","yes","CLCA3P","transcribed_unprocessed_pseudogene","chr1:86634273-86655376:+","gi|397467278|ref|XP_003805351.1|",2611,0,"PREDICTED: LOW QUALITY PROTEIN: epithelial chloride channel protein-like [Pan paniscus]","gi|218749809|ref|NR_024604.1|",3412,0,"Homo sapiens chloride channel accessory 3, pseudogene (CLCA3P), non-coding RNA","P54281",839,0,"Calcium-activated chloride channel regulator 1","alr4359",56.6,3e-07,"COG2304","pfam08434","CLCA_N","Calcium-activated chloride channel. The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumor suppressors. The domain described here is found at the N-terminus of CLCAs.","GO:0006816|calcium ion transport;GO:1902476|chloride transmembrane transport;","GO:0016324|apical plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0046872|metal ion binding;GO:0008237|metallopeptidase activity;","K05030","CLCA4; calcium-activated chloride channel regulator 4"]
["ENSG00000171320",92,112,92,267.185252541482,404,461,542,0.249161330380698,-2.0048479141536,1.67327041910236e-47,4.62378794321582e-46,"down","yes","ESCO2","protein_coding","chr8:27771949-27812640:+","gi|119583942|gb|EAW63538.1|",3300,0,"establishment of cohesion 1 homolog 2 (S. cerevisiae) [Homo sapiens]","gi|21733242|emb|AL832666.1|",3726,0,"Homo sapiens mRNA; cDNA DKFZp313K1012 (from clone DKFZp313K1012)","Q56NI9",1187,0,"N-acetyltransferase ESCO2",".",".",".",".","pfam13880","Acetyltransf_13","ESCO1/2 acetyl-transferase.","GO:0007049|cell cycle;GO:0007059|chromosome segregation;GO:0006302|double-strand break repair;GO:0002244|hematopoietic progenitor cell differentiation;GO:0034421|post-translational protein acetylation;GO:0071168|protein localization to chromatin;GO:0006275|regulation of DNA replication;","GO:0030054|cell junction;GO:0000785|chromatin;GO:0010369|chromocenter;GO:0005694|chromosome;GO:0005794|Golgi apparatus;GO:0031618|nuclear pericentric heterochromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0035861|site of double-strand break;GO:0001741|XY body;","GO:0016407|acetyltransferase activity;GO:0004468|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0046872|metal ion binding;GO:0008080|N-acetyltransferase activity;","K11268","ESCO, ECO1; N-acetyltransferase [EC:2.3.1.-]"]
["ENSG00000234805",6,1,2,8.10530012977763,16,10,16,0.246462886121836,-2.02055768170918,0.0102356877676189,0.0271375870325545,"down","yes","AC090505.1","processed_pseudogene","chr3:194755589-194757422:+","gi|821005731|ref|XP_012366081.1|",1552,0,"PREDICTED: LOW QUALITY PROTEIN: protein FAM151A-like [Nomascus leucogenys]","gi|426214285|ref|NG_022289.2|",1834,0,"Homo sapiens family with sequence similarity 151 member A pseudogene (LOC285303) on chromosome 3","Q8WW52",531,0,"Protein FAM151A",".",".",".",".","pfam10223","DUF2181","Uncharacterized conserved protein (DUF2181). This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.",".","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0016020|membrane;",".",".","."]
["ENSG00000256663",79,109,91,254.405861739376,364,454,532,0.246150169028931,-2.02238936462956,6.90690284926718e-45,1.80760301433739e-43,"down","yes","AC112777.1","processed_pseudogene","chr12:20551590-20553012:+","gi|119616815|gb|EAW96409.1|",2279,0,"hCG23738, isoform CRA_b [Homo sapiens]","gi|347800642|ref|NG_030033.1|",1423,0,"Homo sapiens phosphodiesterase 3A (PDE3A), RefSeqGene on chromosome 12","Q96T88",876,0,"E3 ubiquitin-protein ligase UHRF1","DR1533",117,1e-28,"COG3440","pfam02182","SAD_SRA","SAD/SRA domain. The domain goes by several names including SAD, SRA and YDG. It adopts a beta barrel, modified PUA-like, fold that is widely present in eukaryotic chromatin proteins and in bacteria. Versions of this domain are known to bind hemi-methylated CpG dinucleotides and also other 5mC containing dinucleotides. The domain binds DNA by flipping out the methylated cytosine base from the DNA double helix.The conserved tyrosine and aspartate residues and a glycine rich patch are critical for recognition of the flipped out base. Mammalian UHRF1 that contains this domain plays an important role in maintenance of methylation at CpG dinucleotides by recruiting DNMT1 to hemimethylated sites associated with replication forks. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA methylation to chromatin-protein ubiquitination. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or hemi-methylated DNA.","GO:0007049|cell cycle;GO:0008283|cell proliferation;GO:0006281|DNA repair;GO:0010390|histone monoubiquitination;GO:0016574|histone ubiquitination;GO:0010216|maintenance of DNA methylation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032270|positive regulation of cellular protein metabolic process;GO:2000373|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051865|protein autoubiquitination;GO:0090308|regulation of methylation-dependent chromatin silencing;GO:0006351|transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0000791|euchromatin;GO:0000792|heterochromatin;GO:0000790|nuclear chromatin;GO:0005720|nuclear heterochromatin;GO:0016363|nuclear matrix;GO:0005634|nucleus;GO:0005657|replication fork;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0044729|hemi-methylated DNA-binding;GO:0042393|histone binding;GO:0042802|identical protein binding;GO:0008327|methyl-CpG binding;GO:0035064|methylated histone binding;GO:0031493|nucleosomal histone binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10638","UHRF1, NP95; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]"]
["ENSG00000239213",6,8,6,18.1984856213449,27,24,47,0.245667298775955,-2.02522226418602,7.87682361216288e-05,0.00030440427535844,"down","yes","NCK1-DT","antisense","chr3:136841726-136862054:-","gi|119599516|gb|EAW79110.1|",336,3e-35,"hCG1786951, partial [Homo sapiens]","gi|551850809|tpe|HG496078.1|",1194,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000357306.1 (RP11-85F14.5 gene), antisense",".",".",".",".",".",".",".",".","pfam08385","DHC_N1","Dynein heavy chain, N-terminal region 1. Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.",".",".",".",".","."]
["ENSG00000105011",357,349,336,950.8680908319,1397,1633,2019,0.24523846240241,-2.02774283051775,1.87253324116958e-166,2.49085663142613e-164,"down","yes","ASF1B","protein_coding","chr19:14119509-14136956:-","gi|8922549|ref|NP_060624.1|",973,2e-124,"histone chaperone ASF1B [Homo sapiens]","gi|931605013|ref|XM_003814863.3|",1967,0,"PREDICTED: Pan paniscus anti-silencing function 1B histone chaperone (ASF1B), mRNA","Q9NVP2",379,5e-126,"Histone chaperone ASF1B","YJL115w",197,2e-56,"COG5137","pfam04729","ASF1_hist_chap","ASF1 like histone chaperone. This family includes the yeast and human ASF1 protein. These proteins have histone chaperone activity. ASF1 participates in both the replication-dependent and replication-independent pathways. The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers.","GO:0030154|cell differentiation;GO:0006335|DNA replication-dependent nucleosome assembly;GO:0006336|DNA replication-independent nucleosome assembly;GO:0007275|multicellular organismal development;GO:0006355|regulation of transcription, DNA-templated;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;","GO:0042393|histone binding;","K10753","ASF1; histone chaperone ASF1"]
["ENSG00000101057",1129,1134,1122,3089.02886365482,4301,5361,6845,0.245177982572691,-2.02809866667188,0,0,"down","yes","MYBL2","protein_coding","chr20:43667019-43716496:+","gi|519666783|ref|NP_001265539.1|",3466,0,"myb-related protein B isoform 2 [Homo sapiens]","gi|519666782|ref|NM_001278610.1|",2704,0,"Homo sapiens MYB proto-oncogene like 2 (MYBL2), transcript variant 2, mRNA","P10244",1322,0,"Myb-related protein B","ECU11g1690",147,7e-39,"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0030154|cell differentiation;GO:1990830|cellular response to leukemia inhibitory factor;GO:0090307|mitotic spindle assembly;GO:0043525|positive regulation of neuron apoptotic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051726|regulation of cell cycle;GO:0006357|regulation of transcription from RNA polymerase II promoter;","GO:0031523|Myb complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135|transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["ENSG00000146966",3,7,10,18.4796587482844,27,27,45,0.244452748453733,-2.03237246880791,9.54661937756261e-05,0.000365492645006803,"down","yes","DENND2A","protein_coding","chr7:140518420-140673993:-","gi|795161078|ref|XP_011796679.1|",4941,0,"PREDICTED: DENN domain-containing protein 2A [Colobus angolensis palliatus]","gi|968121874|ref|NM_001318052.1|",3735,0,"Homo sapiens DENN domain containing 2A (DENND2A), transcript variant 2, mRNA","Q9ULE3",1885,0,"DENN domain-containing protein 2A",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0015031|protein transport;GO:0042147|retrograde transport, endosome to Golgi;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;","GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["ENSG00000104889",7,6,3,14.4707815560919,15,30,34,0.24417772571592,-2.03399649351716,0.000416811783249072,0.0014514290802145,"down","yes","RNASEH2A","protein_coding","chr19:12806556-12815201:+","gi|38455391|ref|NP_006388.2|",1597,0,"ribonuclease H2 subunit A [Homo sapiens]","gi|255708431|ref|NG_012662.1|",1875,0,"Homo sapiens ribonuclease H2 subunit A (RNASEH2A), RefSeqGene (LRG_278) on chromosome 19","O75792",619,0,"Ribonuclease H2 subunit A","SPAC4G9.02",192,2e-53,"COG0164","pfam01351","RNase_HII","Ribonuclease HII.","GO:0006260|DNA replication;GO:0043137|DNA replication, removal of RNA primer;GO:0006298|mismatch repair;GO:0006401|RNA catabolic process;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0032299|ribonuclease H2 complex;","GO:0046872|metal ion binding;GO:0004540|ribonuclease activity;GO:0003723|RNA binding;GO:0004523|RNA-DNA hybrid ribonuclease activity;","K10743","RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"]
["ENSG00000284681",13,14,16,39.7312342362205,68,57,84,0.243025366906475,-2.04082118517099,6.76851522235441e-09,4.04558790234806e-08,"down","yes","AC007240.1","protein_coding","chr2:10122739-10199288:+","gi|260064013|ref|NP_001159403.1|",1841,0,"ribonucleoside-diphosphate reductase subunit M2 isoform 1 [Homo sapiens]","gi|260064012|ref|NM_001165931.1|",1079,0,"Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 1, mRNA","P31350",673,0,"Ribonucleoside-diphosphate reductase subunit M2","SPBC25D12.04",380,2e-124,"COG0208","pfam00268","Ribonuc_red_sm","Ribonucleotide reductase, small chain.","GO:0009263|deoxyribonucleotide biosynthetic process;GO:0006260|DNA replication;GO:0070317|negative regulation of G0 to G1 transition;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;","GO:0005829|cytosol;GO:0005971|ribonucleoside-diphosphate reductase complex;","GO:0046872|metal ion binding;GO:0004748|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;","K10808","RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"]
["ENSG00000101003",337,329,319,906.041723659555,1307,1612,1903,0.242797600055271,-2.04217393361284,5.85193884295208e-163,7.57531519482279e-161,"down","yes","GINS1","protein_coding","chr20:25407727-25452628:+","gi|966967890|ref|XP_015005117.1|",1121,2e-141,"PREDICTED: DNA replication complex GINS protein PSF1 [Macaca mulatta]","gi|971064225|ref|NM_021067.4|",3249,0,"Homo sapiens GINS complex subunit 1 (Psf1 homolog) (GINS1), transcript variant 1, mRNA","Q14691",409,2e-133,"DNA replication complex GINS protein PSF1","SPBP23A10.09",81.6,4e-16,"COG5230","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006271|DNA strand elongation involved in DNA replication;GO:1902983|DNA strand elongation involved in mitotic DNA replication;GO:0001833|inner cell mass cell proliferation;","GO:0005737|cytoplasm;GO:0000811|GINS complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0043138|3'-5' DNA helicase activity;","K10732","GINS1, PSF1; GINS complex subunit 1"]
["ENSG00000196081",7,5,3,13.7952928985266,22,23,28,0.241232633484375,-2.05150300945088,0.000442819925987975,0.00153589475498221,"down","yes","ZNF724","protein_coding","chr19:23221599-23250390:-","gi|281185498|sp|A8MTY0.3|ZN724_HUMAN",3268,0,"RecName: Full=Putative zinc finger protein 724","gi|194373790|dbj|AK301230.1|",2725,0,"Homo sapiens cDNA FLJ56866 complete cds, moderately similar to Zinc finger protein 43","A8MTY0",1263,0,"Zinc finger protein 724",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["ENSG00000276043",1178,1151,1087,3167.1443415999,4618,5466,6826,0.240298000367474,-2.05710345171268,0,0,"down","yes","UHRF1","protein_coding","chr19:4903080-4962154:+","gi|115430233|ref|NP_037414.3|",4036,0,"E3 ubiquitin-protein ligase UHRF1 isoform 2 [Homo sapiens]","gi|586798165|ref|NM_001290050.1|",4309,0,"Homo sapiens ubiquitin like with PHD and ring finger domains 1 (UHRF1), transcript variant 3, mRNA","Q96T88",1544,0,"E3 ubiquitin-protein ligase UHRF1","DR1533",119,1e-27,"COG3440","pfam02182","SAD_SRA","SAD/SRA domain. The domain goes by several names including SAD, SRA and YDG. It adopts a beta barrel, modified PUA-like, fold that is widely present in eukaryotic chromatin proteins and in bacteria. Versions of this domain are known to bind hemi-methylated CpG dinucleotides and also other 5mC containing dinucleotides. The domain binds DNA by flipping out the methylated cytosine base from the DNA double helix.The conserved tyrosine and aspartate residues and a glycine rich patch are critical for recognition of the flipped out base. Mammalian UHRF1 that contains this domain plays an important role in maintenance of methylation at CpG dinucleotides by recruiting DNMT1 to hemimethylated sites associated with replication forks. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA methylation to chromatin-protein ubiquitination. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or hemi-methylated DNA.","GO:0007049|cell cycle;GO:0008283|cell proliferation;GO:0006281|DNA repair;GO:0010390|histone monoubiquitination;GO:0016574|histone ubiquitination;GO:0010216|maintenance of DNA methylation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032270|positive regulation of cellular protein metabolic process;GO:2000373|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051865|protein autoubiquitination;GO:0090308|regulation of methylation-dependent chromatin silencing;GO:0006351|transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0000791|euchromatin;GO:0000792|heterochromatin;GO:0000790|nuclear chromatin;GO:0005720|nuclear heterochromatin;GO:0016363|nuclear matrix;GO:0005634|nucleus;GO:0005657|replication fork;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0044729|hemi-methylated DNA-binding;GO:0042393|histone binding;GO:0042802|identical protein binding;GO:0008327|methyl-CpG binding;GO:0035064|methylated histone binding;GO:0031493|nucleosomal histone binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10638","UHRF1, NP95; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]"]
["ENSG00000138356",125,157,124,378.458963001823,516,707,806,0.238823872728204,-2.06598103992125,3.54259944263545e-66,1.3530625356347e-64,"down","yes","AOX1","protein_coding","chr2:200585868-200677064:+","gi|71773480|ref|NP_001150.3|",7115,0,"aldehyde oxidase [Homo sapiens]","gi|397500092|ref|XM_003820713.1|",4966,0,"PREDICTED: Pan paniscus aldehyde oxidase 1 (AOX1), mRNA","Q06278",2745,0,"Aldehyde oxidase","PA1523",494,3e-153,"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0017144|drug metabolic process;GO:0055114|oxidation-reduction process;GO:0042816|vitamin B6 metabolic process;GO:0009115|xanthine catabolic process;","GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0051537|2 iron, 2 sulfur cluster binding;GO:0004031|aldehyde oxidase activity;GO:0009055|electron carrier activity;GO:0050660|flavin adenine dinucleotide binding;GO:0042802|identical protein binding;GO:0005506|iron ion binding;GO:0043546|molybdopterin cofactor binding;GO:0051287|NAD binding;GO:0016614|oxidoreductase activity, acting on CH-OH group of donors;GO:0016903|oxidoreductase activity, acting on the aldehyde or oxo group of donors;GO:0042803|protein homodimerization activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSG00000138347",6,9,8,21.5853110799136,28,47,40,0.237842755462894,-2.07192001247928,1.24980535042588e-05,5.4001446234351e-05,"down","yes","MYPN","protein_coding","chr10:68106117-68212017:+","gi|372220099|ref|NP_001243197.1|",5075,0,"myopalladin isoform b [Homo sapiens]","gi|372220098|ref|NM_001256268.1|",6113,0,"Homo sapiens myopalladin (MYPN), transcript variant 5, mRNA","Q86TC9",1947,0,"Myopalladin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0048739|cardiac muscle fiber development;GO:0030334|regulation of cell migration;GO:0051493|regulation of cytoskeleton organization;GO:0045214|sarcomere organization;","GO:0031674|I band;GO:0005634|nucleus;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0008092|cytoskeletal protein binding;GO:0051371|muscle alpha-actinin binding;GO:0017124|SH3 domain binding;",".","."]
["ENSG00000221818",2,1,4,6.63911327647917,10,13,12,0.236746212793586,-2.07858674766303,0.0144757259358433,0.037059324239684,"down","yes","EBF2","protein_coding","chr8:25841730-26045397:-","gi|291385869|ref|XP_002709503.1|",2700,0,"PREDICTED: transcription factor COE2 [Oryctolagus cuniculus]","gi|426359157|ref|XM_004046802.1|",5005,0,"PREDICTED: Gorilla gorilla gorilla early B-cell factor 2, transcript variant 1 (EBF2), mRNA","Q9HAK2",1044,0,"Transcription factor COE2",".",".",".",".","pfam01833","TIG","IPT/TIG domain. This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.","GO:0060612|adipose tissue development;GO:0050873|brown fat cell differentiation;GO:0001709|cell fate determination;GO:0035563|positive regulation of chromatin binding;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0046872|metal ion binding;GO:0046983|protein dimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09103","EBF, COE; early B-cell factor"]
["ENSG00000197635",3,6,4,12.3039617412081,19,23,23,0.236104397443369,-2.08250318288175,0.000809731857844024,0.00269231306224712,"down","yes","DPP4","protein_coding","chr2:161992241-162074542:-","gi|18765694|ref|NP_001926.2|",4022,0,"dipeptidyl peptidase 4 [Homo sapiens]","gi|47078262|ref|NM_001935.3|",3900,0,"Homo sapiens dipeptidyl peptidase 4 (DPP4), mRNA","P27487",1553,0,"Dipeptidyl peptidase 4","SPACUNK4.08",335,1e-97,"COG1506","pfam00930","DPPIV_N","Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.","GO:0001662|behavioral fear response;GO:0007155|cell adhesion;GO:0043542|endothelial cell migration;GO:0035641|locomotory exploration behavior;GO:0010716|negative regulation of extracellular matrix disassembly;GO:0008284|positive regulation of cell proliferation;GO:0006508|proteolysis;GO:0036343|psychomotor behavior;GO:0033632|regulation of cell-cell adhesion mediated by integrin;GO:0050796|regulation of insulin secretion;GO:0001666|response to hypoxia;GO:0042110|T cell activation;GO:0031295|T cell costimulation;","GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0046581|intercellular canaliculus;GO:0071438|invadopodium membrane;GO:0030027|lamellipodium;GO:0031258|lamellipodium membrane;GO:0005765|lysosomal membrane;GO:0016020|membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0008239|dipeptidyl-peptidase activity;GO:0042802|identical protein binding;GO:0002020|protease binding;GO:0042803|protein homodimerization activity;GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;GO:0005102|receptor binding;GO:0001618|virus receptor activity;","K01278","DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5]"]
["ENSG00000133401",20,20,11,47.9154108710786,79,77,98,0.235876982151215,-2.08389345357372,9.86771022212944e-11,6.98452824823606e-10,"down","yes","PDZD2","protein_coding","chr5:31639410-32110931:+","gi|87196343|ref|NP_835260.2|",13908,0,"PDZ domain-containing protein 2 [Homo sapiens]","gi|966209852|ref|NM_178140.3|",11704,0,"Homo sapiens PDZ domain containing 2 (PDZD2), mRNA","O15018",5335,0,"PDZ domain-containing protein 2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007155|cell adhesion;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0005634|nucleus;",".",".","."]
["ENSG00000093009",308,320,301,874.295439464311,1211,1551,1948,0.235787852016722,-2.08443870348528,1.43672985058466e-157,1.79945749078421e-155,"down","yes","CDC45","protein_coding","chr22:19479459-19520612:+","gi|4502713|ref|NP_003495.1|",2784,0,"cell division control protein 45 homolog isoform 2 [Homo sapiens]","gi|768025955|ref|XM_011530415.1|",2066,0,"PREDICTED: Homo sapiens cell division cycle 45 (CDC45), transcript variant X2, mRNA","O75419",1075,0,"Cell division control protein 45 homolog",".",".",".",".","pfam02724","CDC45","CDC45-like protein. CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. Homologues of CDC45 have been identified in human, mouse and smut fungus among others.","GO:0006260|DNA replication;GO:0000076|DNA replication checkpoint;GO:0006270|DNA replication initiation;GO:0000727|double-strand break repair via break-induced replication;GO:0000082|G1/S transition of mitotic cell cycle;GO:1902977|mitotic DNA replication preinitiation complex assembly;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:0006267|pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0031938|regulation of chromatin silencing at telomere;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0031261|DNA replication preinitiation complex;GO:0005656|nuclear pre-replicative complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0031298|replication fork protection complex;","GO:0043138|3'-5' DNA helicase activity;GO:0003682|chromatin binding;GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;","K06628","CDC45; cell division control protein 45"]
["ENSG00000260167",4,2,1,6.56367694286087,12,12,10,0.235550952293936,-2.08588893028988,0.0151687256039867,0.0386542977209268,"down","yes","AC093249.2","antisense","chr16:30585907-30608593:+","gi|355563670|gb|EHH20232.1|",216,9e-20,"hypothetical protein EGK_03041, partial [Macaca mulatta]","gi|551881356|tpe|HG507934.1|",482,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000434412.1 (RP11-146F11.5 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000167900",903,903,832,2485.80406408024,3552,4196,5645,0.235357027062626,-2.08707716662307,0,0,"down","yes","TK1","protein_coding","chr17:78174075-78187233:-","gi|119609911|gb|EAW89505.1|",1416,0,"thymidine kinase 1, soluble, isoform CRA_a [Homo sapiens]","gi|795092803|ref|XM_011954629.1|",1209,0,"PREDICTED: Colobus angolensis palliatus thymidine kinase 1, soluble (TK1), transcript variant X1, mRNA","P04183",465,9e-161,"Thymidine kinase, cytosolic","DR1984",111,8e-27,"COG1435","pfam00265","TK","Thymidine kinase.","GO:0071897|DNA biosynthetic process;GO:0006259|DNA metabolic process;GO:0006139|nucleobase-containing compound metabolic process;GO:0051289|protein homotetramerization;GO:0043097|pyrimidine nucleoside salvage;GO:0046104|thymidine metabolic process;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0019206|nucleoside kinase activity;GO:0004797|thymidine kinase activity;GO:0008270|zinc ion binding;","K00857","tdk, TK; thymidine kinase [EC:2.7.1.21]"]
["ENSG00000250072",8,6,5,17.9768082360152,22,44,30,0.233268042205705,-2.09993942369652,7.09104058483859e-05,0.000275361366620428,"down","yes","SH3TC2-DT","lincRNA","chr5:149063317-149109787:+","gi|119582197|gb|EAW61793.1|",478,2e-52,"hCG1980447 [Homo sapiens]","gi|551857679|tpe|HG498597.1|",3091,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000373405.1 (CTC-529P8.1 gene), lincRNA",".",".",".",".",".",".",".",".","pfam03038","Herpes_UL95","UL95 family. Members of this family, found in several herpesviruses, include EBV BGLF3 and other UL95 proteins (e.g. HCMV UL95, HVS-1 34, HSV6 U67). Their function is unknown.",".",".",".",".","."]
["ENSG00000061337",14,10,9,31.3666150495155,51,60,54,0.233073214749712,-2.10114487835768,1.1767714320347e-07,6.28567360318067e-07,"down","yes","LZTS1","protein_coding","chr8:20246165-20303963:-","gi|10440566|ref|NP_066300.1|",2562,0,"leucine zipper putative tumor suppressor 1 [Homo sapiens]","gi|767950521|ref|XM_005273394.3|",5706,0,"PREDICTED: Homo sapiens leucine zipper, putative tumor suppressor 1 (LZTS1), transcript variant X1, mRNA","Q9Y250",991,0,"Leucine zipper putative tumor suppressor 1",".",".",".",".","pfam06818","Fez1","Fez1. This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.","GO:0044772|mitotic cell cycle phase transition;GO:0016242|negative regulation of macroautophagy;GO:0006351|transcription, DNA-templated;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0043197|dendritic spine;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0008017|microtubule binding;",".","."]
["ENSG00000127564",324,345,307,928.889763855801,1345,1571,2092,0.232608009510649,-2.10402732016416,9.94696252396395e-162,1.27904675441478e-159,"down","yes","PKMYT1","protein_coding","chr16:2968024-2980539:-","gi|194381140|dbj|BAG64138.1|",2485,0,"unnamed protein product [Homo sapiens]","gi|194381139|dbj|AK303005.1|",2305,0,"Homo sapiens cDNA FLJ61000 complete cds, highly similar to Membrane-associated tyrosine- andthreonine-specific cdc2-inhibitory kinase (EC 2.7.11.1)","Q99640",751,0,"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0010923|negative regulation of phosphatase activity;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0007088|regulation of mitotic nuclear division;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016020|membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K06633","PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]"]
["ENSG00000214357",134,117,126,361.418387751753,522,627,801,0.230441389282465,-2.11752823422767,1.36760050416657e-73,5.96793631772958e-72,"down","yes","NEURL1B","protein_coding","chr5:172641266-172691540:+","gi|217416388|ref|NP_001136123.1|",2278,0,"E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2 [Homo sapiens]","gi|815890854|ref|NM_001142651.2|",6424,0,"Homo sapiens neuralized E3 ubiquitin protein ligase 1B (NEURL1B), transcript variant 1, mRNA","A8MQ27",882,0,"E3 ubiquitin-protein ligase NEURL1B",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0007219|Notch signaling pathway;GO:0016567|protein ubiquitination;GO:0070086|ubiquitin-dependent endocytosis;","GO:0005769|early endosome;","GO:0016874|ligase activity;GO:0046872|metal ion binding;GO:0016740|transferase activity;","K01931","NEUR; protein neuralized [EC:2.3.2.27]"]
["ENSG00000132164",3,4,0,6.71988403903114,12,13,10,0.229026264300287,-2.12641504153004,0.0147325587312004,0.0376223477833169,"down","yes","SLC6A11","protein_coding","chr3:10816200-10940733:+","gi|7657587|ref|NP_055044.1|",3191,0,"sodium- and chloride-dependent GABA transporter 3 isoform 1 [Homo sapiens]","gi|959092934|ref|NM_014229.2|",4296,0,"Homo sapiens solute carrier family 6 member 11 (SLC6A11), transcript variant 1, mRNA","P48066",1213,0,"Sodium- and chloride-dependent GABA transporter 3","VC2012",235,4e-65,"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0007420|brain development;GO:0042493|response to drug;","GO:0042995|cell projection;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0005332|gamma-aminobutyric acid:sodium symporter activity;GO:0042165|neurotransmitter binding;GO:0005215|transporter activity;","K05039","SLC6A6S; solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13"]
["ENSG00000108984",27,20,20,64.9523397463146,89,137,123,0.226870494502878,-2.14005910245841,2.16363300814041e-14,1.94103039353545e-13,"down","yes","MAP2K6","protein_coding","chr17:69414698-69553861:+","gi|507673141|ref|XP_004709231.1|",1807,0,"PREDICTED: dual specificity mitogen-activated protein kinase kinase 6 [Echinops telfairi]","gi|117414198|gb|AC002546.2|",12187,0,"Homo sapiens chromosome 17, clone RP5-193H18, complete sequence","P52564",680,0,"Dual specificity mitogen-activated protein kinase kinase 6",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000187|activation of MAPK activity;GO:0032147|activation of protein kinase activity;GO:0006915|apoptotic process;GO:0060048|cardiac muscle contraction;GO:0007050|cell cycle arrest;GO:0072709|cellular response to sorbitol;GO:0006975|DNA damage induced protein phosphorylation;GO:0070423|nucleotide-binding oligomerization domain containing signaling pathway;GO:0022602|ovulation cycle process;GO:0043065|positive regulation of apoptotic process;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0032308|positive regulation of prostaglandin secretion;GO:0042981|regulation of apoptotic process;GO:0007346|regulation of mitotic cell cycle;GO:0006355|regulation of transcription, DNA-templated;GO:0042493|response to drug;GO:0002931|response to ischemia;GO:0007165|signal transduction;GO:0023014|signal transduction by protein phosphorylation;GO:0031098|stress-activated protein kinase signaling cascade;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0004708|MAP kinase kinase activity;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;","K04433","MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]"]
["ENSG00000174371",274,242,235,730.946546564142,1110,1282,1539,0.226298903869375,-2.14369849828983,3.13327653143788e-139,3.24917407195559e-137,"down","yes","EXO1","protein_coding","chr1:241847967-241895148:+","gi|284055278|ref|NP_006018.4|",4350,0,"exonuclease 1 isoform b [Homo sapiens]","gi|284172360|ref|NM_130398.3|",3462,0,"Homo sapiens exonuclease 1 (EXO1), transcript variant 2, mRNA","Q9UQ84",1676,0,"Exonuclease 1","SPBC29A10.05",229,2e-63,"COG0258","pfam00867","XPG_I","XPG I-region.","GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0006260|DNA replication;GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0045190|isotype switching;GO:0051321|meiotic cell cycle;GO:0006298|mismatch repair;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0090656|t-circle formation;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0035312|5'-3' exodeoxyribonuclease activity;GO:0008409|5'-3' exonuclease activity;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0051908|double-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0004527|exonuclease activity;GO:0048256|flap endonuclease activity;GO:0046872|metal ion binding;GO:0004523|RNA-DNA hybrid ribonuclease activity;GO:0045145|single-stranded DNA 5'-3' exodeoxyribonuclease activity;","K10746","EXO1; exonuclease 1 [EC:3.1.-.-]"]
["ENSG00000119915",8,4,6,17.5270066443342,24,34,37,0.225169992363792,-2.15091351770233,3.98533452622496e-05,0.00016051186540369,"down","yes","ELOVL3","protein_coding","chr10:102226328-102229589:+","gi|23097310|ref|NP_689523.1|",1439,0,"elongation of very long chain fatty acids protein 3 [Homo sapiens]","gi|528319757|ref|NM_152310.2|",1371,0,"Homo sapiens ELOVL fatty acid elongase 3 (ELOVL3), mRNA","Q9HB03",558,0,"Elongation of very long chain fatty acids protein 3",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0036109|alpha-linolenic acid metabolic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0043651|linoleic acid metabolic process;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0030148|sphingolipid biosynthetic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;","K10248","ELOVL3; elongation of very long chain fatty acids protein 3 [EC:2.3.1.199]"]
["ENSG00000224046",2,3,2,6.91038943291486,10,10,18,0.222005223648867,-2.17133447216939,0.00899082467972782,0.0241410382940624,"down","yes","AC005076.1","antisense","chr7:87151423-87152420:-","gi|119597372|gb|EAW76966.1|",334,2e-36,"hCG2038226, partial [Homo sapiens]","gi|551862093|tpe|HG500374.1|",769,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000334361.1 (AC005076.5 gene), antisense",".",".",".",".",".",".",".",".","pfam13507","GATase_5","CobB/CobQ-like glutamine amidotransferase domain. This family captures members that are not found in pfam00310, pfam07685 and pfam13230.",".",".",".",".","."]
["ENSG00000077063",3,0,3,5.97517773640534,11,12,8,0.221928475331823,-2.17183330529584,0.0195121822514006,0.0481205691426946,"down","yes","CTTNBP2","protein_coding","chr7:117710651-117874139:-","gi|16975496|ref|NP_219499.1|",8162,0,"cortactin-binding protein 2 [Homo sapiens]","gi|92091570|ref|NM_033427.2|",5967,0,"Homo sapiens cortactin binding protein 2 (CTTNBP2), mRNA","Q8WZ74",3146,0,"Cortactin-binding protein 2","all2748",90.5,8e-18,"COG0666","pfam09727","CortBP2","Cortactin-binding protein-2. This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.","GO:0007420|brain development;","GO:0005938|cell cortex;GO:0043197|dendritic spine;GO:0008021|synaptic vesicle;","GO:0017124|SH3 domain binding;",".","."]
["ENSG00000161888",129,137,143,407.34094357557,591,730,891,0.220459509206989,-2.18141438799544,1.2180108078017e-83,6.31532055399978e-82,"down","yes","SPC24","protein_coding","chr19:11131520-11155808:-","gi|32698866|ref|NP_872319.1|",1008,6e-129,"kinetochore protein Spc24 isoform 1 [Homo sapiens]","gi|949474700|ref|NM_182513.3|",2315,0,"Homo sapiens SPC24, NDC80 kinetochore complex component (SPC24), transcript variant 1, mRNA","Q8NBT2",390,2e-129,"Kinetochore protein Spc24",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0031262|Ndc80 complex;GO:0005730|nucleolus;GO:0005634|nucleus;",".","K11549","SPBC24, SPC24; kinetochore protein Spc24, animal type"]
["ENSG00000247095",11,14,7,31.8275241237947,45,56,73,0.219460724184315,-2.18796532412247,2.55249408780484e-08,1.45701408598934e-07,"down","yes","MIR210HG","lincRNA","chr11:565660-568457:-","gi|355779528|gb|EHH64004.1|",292,2e-27,"hypothetical protein EGM_17106, partial [Macaca fascicularis]","gi|551869822|tpe|HG503419.1|",1965,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000383231.1 (MIR210HG gene), lincRNA","Q8WTZ3",97.8,3e-21,"Zinc finger protein ENSP00000375192",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSG00000261441",3,1,3,7.05910506003285,13,13,11,0.218594242603676,-2.1936726914828,0.00880563031082938,0.0236946145975554,"down","yes","AC124068.2","antisense","chr15:89335053-89336161:+","gi|119622453|gb|EAX02048.1|",172,1e-12,"hCG2045705, partial [Homo sapiens]","gi|551880123|tpe|HG507382.1|",1109,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000422015.1 (RP11-217B1.2 gene), antisense",".",".",".",".",".",".",".",".","pfam05054","DUF673","Protein of unknown function (DUF673). Family of uncharacterized viral proteins.",".",".",".",".","."]
["ENSG00000065328",375,392,409,1183.55411316905,1648,2193,2624,0.217544440135704,-2.20061794903235,3.05125506347607e-199,5.60501025374538e-197,"down","yes","MCM10","protein_coding","chr10:13161554-13211104:+","gi|33383235|ref|NP_060988.3|",3973,0,"protein MCM10 homolog isoform 2 [Homo sapiens]","gi|12053186|emb|AL136840.1|",4572,0,"Homo sapiens mRNA; cDNA DKFZp434H152 (from clone DKFZp434H152)","Q7L590",1530,0,"Protein MCM10 homolog",".",".",".",".","pfam09332","Mcm10","Mcm10 replication factor. Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha.","GO:0008283|cell proliferation;GO:0006974|cellular response to DNA damage stimulus;GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0031298|replication fork protection complex;","GO:0003688|DNA replication origin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0003697|single-stranded DNA binding;","K10736","MCM10; minichromosome maintenance protein 10"]
["ENSG00000279968",6,5,5,16.1334093370055,23,30,35,0.216338776888749,-2.20863581557394,5.02941404739499e-05,0.000199809141392697,"down","yes","GVQW2","protein_coding","chr6:138725211-138773652:-","gi|337298891|ref|NP_001229669.1|",570,1e-65,"protein GVQW2 [Homo sapiens]","gi|337298890|ref|NM_001242740.1|",2685,0,"Homo sapiens GVQW motif containing 2 (GVQW2), mRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000085999",135,126,114,381.734617204588,552,723,805,0.214068233626368,-2.22385737011171,1.0939332554752e-81,5.48046354067679e-80,"down","yes","RAD54L","protein_coding","chr1:46247688-46278473:+","gi|216548186|ref|NP_003570.2|",3895,0,"DNA repair and recombination protein RAD54-like [Homo sapiens]","gi|216548185|ref|NM_003579.3|",3108,0,"Homo sapiens RAD54-like (S. cerevisiae) (RAD54L), transcript variant 1, mRNA","Q92698",1502,0,"DNA repair and recombination protein RAD54-like","SPAC15A10.03c",647,0,"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0008340|determination of adult lifespan;GO:0006310|DNA recombination;GO:0006281|DNA repair;GO:0000724|double-strand break repair via homologous recombination;GO:0051321|meiotic cell cycle;GO:0042493|response to drug;GO:0010212|response to ionizing radiation;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0036310|annealing helicase activity;GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0004386|helicase activity;","K10875","RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-]"]
["ENSG00000274825",2,3,2,7.18731349995084,10,11,19,0.211423490000705,-2.24179242003592,0.00637078895425708,0.0177264537434666,"down","yes","AL023803.2","lincRNA","chr20:38955910-38956547:+","gi|68565262|sp|Q96MD7.1|CI085_HUMAN",289,7e-29,"RecName: Full=Uncharacterized protein C9orf85","gi|666671019|tpe|LK937926.1|",638,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473947.1 (RP4-616B8.5 gene), lincRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000184260",4,8,7,19.8255532222975,25,43,41,0.208996151578075,-2.25845171789385,8.16636146267447e-06,3.60276257758612e-05,"down","yes","HIST2H2AC","protein_coding","chr1:149886975-149887364:+","gi|483521767|gb|EOB06724.1|",549,1e-69,"Histone H2A.J, partial [Anas platyrhynchos]","gi|297139867|gb|AC239868.2|",390,0,"Homo sapiens BAC clone CH17-164C24 from chromosome 1, complete sequence","Q64523",216,4e-71,"Histone H2A type 2-C","SPAC19G12.06c",181,5e-58,"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006342|chromatin silencing;","GO:0000790|nuclear chromatin;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["ENSG00000251365",3,3,3,9.39586696918106,14,19,18,0.208429735334778,-2.26236698253095,0.00167581906476268,0.00526350726610366,"down","yes","AC122710.2","lincRNA","chr5:6765891-6833120:+",".",".",".",".","gi|29501854|gb|AC122710.3|",1113,0,"Homo sapiens chromosome 5 clone RP11-332J15, complete sequence",".",".",".",".",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.",".",".",".",".","."]
["ENSG00000143320",108,116,103,340.942768478269,503,605,764,0.208154296329521,-2.26427475870408,1.2000742486507e-76,5.61821167669288e-75,"down","yes","CRABP2","protein_coding","chr1:156699606-156705816:-","gi|440903652|gb|ELR54289.1|",735,3e-94,"Cellular retinoic acid-binding protein 2, partial [Bos mutus]","gi|315013541|ref|NM_001199723.1|",1033,0,"Homo sapiens cellular retinoic acid binding protein 2 (CRABP2), transcript variant 2, mRNA","P29373",281,1e-93,"Cellular retinoic acid-binding protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0035115|embryonic forelimb morphogenesis;GO:0008544|epidermis development;GO:0048672|positive regulation of collateral sprouting;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:0006355|regulation of transcription, DNA-templated;GO:0042573|retinoic acid metabolic process;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;","GO:0016918|retinal binding;GO:0001972|retinoic acid binding;GO:0005501|retinoid binding;GO:0019841|retinol binding;","K17289","CRABP2; cellular retinoic acid-binding protein 2"]
["ENSG00000259347",4,9,5,18.8563718404177,24,40,40,0.207341372364267,-2.26992007805703,1.28478068940357e-05,5.54314382853649e-05,"down","yes","AC087482.1","antisense","chr15:66984108-67065268:-","gi|426379504|ref|XP_004056435.1|",293,8e-26,"PREDICTED: uncharacterized protein LOC101141481 [Gorilla gorilla gorilla]","gi|229577384|ref|NG_011990.1|",2153,0,"Homo sapiens SMAD family member 3 (SMAD3), RefSeqGene on chromosome 15",".",".",".",".",".",".",".",".","pfam02720","DUF222","Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.",".",".",".",".","."]
["ENSG00000129173",95,78,107,294.605648853032,442,529,644,0.206334331817003,-2.27694420472817,1.44347423868744e-62,5.23340810447433e-61,"down","yes","E2F8","protein_coding","chr11:19224063-19241620:-","gi|38505226|ref|NP_078956.2|",4589,0,"transcription factor E2F8 [Homo sapiens]","gi|373838710|ref|NM_001256371.1|",3519,0,"Homo sapiens E2F transcription factor 8 (E2F8), transcript variant 2, mRNA","A0AVK6",1772,0,"Transcription factor E2F8",".",".",".",".","pfam02319","E2F_TDP","E2F/DP family winged-helix DNA-binding domain. This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.","GO:0033301|cell cycle comprising mitosis without cytokinesis;GO:0008283|cell proliferation;GO:0060718|chorionic trophoblast cell differentiation;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0070365|hepatocyte differentiation;GO:0032466|negative regulation of cytokinesis;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001890|placenta development;GO:0032877|positive regulation of DNA endoreduplication;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0002040|sprouting angiogenesis;GO:0006351|transcription, DNA-templated;GO:0060707|trophoblast giant cell differentiation;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042803|protein homodimerization activity;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09391","E2F7_8; transcription factor E2F7/8"]
["ENSG00000204531",0,2,3,5.36203710939316,8,11,10,0.206028848165741,-2.2790817371305,0.0199475672512872,0.04905631482122,"down","yes","POU5F1","protein_coding","chr6:31164337-31180731:-","gi|795416385|ref|XP_011946105.1|",1297,2e-168,"PREDICTED: POU domain, class 5, transcription factor 1 [Cercocebus atys]","gi|658157326|gb|KF880692.1|",2276,0,"Homo sapiens POU class 5 homeobox 1 transcript variant OCT4B1 (POU5F1) mRNA, 5' UTR and complete cds, alternatively spliced","Q7YR49",385,3e-125,"POU domain, class 5, transcription factor 1",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0007275|multicellular organismal development;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09367","POU5F; POU domain transcription factor, class 5"]
["ENSG00000100206",3,0,5,8.4658749569932,9,12,28,0.203785201982096,-2.2948788019811,0.00469166526784695,0.0134421924667606,"down","yes","DMC1","protein_coding","chr22:38518949-38570286:-","gi|49259489|pdb|1V5W|A",1804,0,"Chain A, Crystal Structure Of The Human Dmc1 Protein","gi|506324312|ref|NM_007068.3|",2281,0,"Homo sapiens DNA meiotic recombinase 1 (DMC1), transcript variant 1, mRNA","Q14565",699,0,"Meiotic recombination protein DMC1/LIM15 homolog","SPAC8E11.03c",412,3e-136,"COG0468","pfam08423","Rad51","Rad51. Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.","GO:0070192|chromosome organization involved in meiosis;GO:0000730|DNA recombinase assembly;GO:0007292|female gamete generation;GO:0007141|male meiosis I;GO:0051321|meiotic cell cycle;GO:0006312|mitotic recombination;GO:0001556|oocyte maturation;GO:0001541|ovarian follicle development;GO:0007131|reciprocal meiotic recombination;GO:0010212|response to ionizing radiation;GO:0007286|spermatid development;GO:0007283|spermatogenesis;GO:0042148|strand invasion;GO:0007129|synapsis;","GO:0005694|chromosome;GO:0000781|chromosome, telomeric region;GO:0000794|condensed nuclear chromosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0008094|DNA-dependent ATPase activity;GO:0003690|double-stranded DNA binding;GO:0000400|four-way junction DNA binding;GO:0000150|recombinase activity;GO:0003697|single-stranded DNA binding;","K10872","DMC1; meiotic recombination protein DMC1"]
["ENSG00000273001",1,4,2,7.64469929566233,18,13,8,0.201598787487923,-2.31044113308535,0.0068220515874969,0.0188353465530547,"down","yes","AL731533.2","lincRNA","chr10:3065424-3066001:-",".",".",".",".","gi|551868004|tpe|HG502592.1|",578,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000472200.1 (RP11-118K6.3 gene), lincRNA",".",".",".",".",".",".",".",".","pfam07099","DUF1361","Protein of unknown function (DUF1361). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.",".",".",".",".","."]
["ENSG00000079308",65,75,83,240.434493504538,342,444,546,0.200406252114643,-2.31900057760129,6.11671687691049e-54,1.92148591403664e-52,"down","yes","TNS1","protein_coding","chr2:217799588-218033982:-","gi|635060628|ref|XP_007964421.1|",8562,0,"PREDICTED: tensin-1 isoform X8 [Chlorocebus sabaeus]","gi|767919475|ref|XM_011511723.1|",10007,0,"PREDICTED: Homo sapiens tensin 1 (TNS1), transcript variant X14, mRNA","Q9HBL0",3111,0,"Tensin-1","SPBC609.02",72.8,4e-12,"COG2453","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0007044|cell-substrate junction assembly;GO:0010761|fibroblast migration;","GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005925|focal adhesion;","GO:0003779|actin binding;GO:0003723|RNA binding;","K18080","TNS; tensin"]
["ENSG00000128408",4,7,0,11.7456513591676,18,20,27,0.200251488355747,-2.32011512947946,0.000670388647570491,0.00225701801960894,"down","yes","RIBC2","protein_coding","chr22:45413691-45432496:+","gi|588282768|ref|NP_056468.3|",1896,0,"RIB43A-like with coiled-coils protein 2 [Homo sapiens]","gi|418203921|ref|NM_015653.4|",1405,0,"Homo sapiens RIB43A domain with coiled-coils 2 (RIBC2), mRNA","Q9H4K1",580,0,"RIB43A-like with coiled-coils protein 2",".",".",".",".","pfam05914","RIB43A","RIB43A. This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilizing doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologues could represent a structural requirement in centriole replication in dividing cells.",".","GO:0005634|nucleus;",".",".","."]
["ENSG00000158246",19,17,27,68.0847085761966,85,136,160,0.19959894703271,-2.32482398500725,1.77830535335407e-16,1.78274187398614e-15,"down","yes","TENT5B","protein_coding","chr1:27005020-27012836:-","gi|635110327|ref|XP_007978044.1|",1984,0,"PREDICTED: protein FAM46B [Chlorocebus sabaeus]","gi|209862820|ref|NM_052943.3|",2368,0,"Homo sapiens family with sequence similarity 46 member B (FAM46B), mRNA","Q96A09",763,0,"Terminal nucleotidyltransferase 5B",".",".",".",".","pfam07984","DUF1693","Domain of unknown function (DUF1693). This family contains many hypothetical proteins. It also includes four nematode prion-like proteins. This domain has been identified as part of the nucleotidyltransferase superfamily.",".",".","GO:0016779|nucleotidyltransferase activity;",".","."]
["ENSG00000243789",2,2,2,6.56808367614136,17,6,11,0.199571934855638,-2.32501924140361,0.0104378739391506,0.0276318573343861,"down","yes","JMJD7","protein_coding","chr15:41828085-41837581:+","gi|167860114|ref|NP_001108104.1|",1643,0,"jmjC domain-containing protein 7 [Homo sapiens]","gi|167860113|ref|NM_001114632.1|",1416,0,"Homo sapiens jumonji domain containing 7 (JMJD7), mRNA","P0C870",637,0,"JmjC domain-containing protein 7",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.",".",".",".","K19219","JMJD7; jumonji domain-containing protein 7"]
["ENSG00000143847",52,33,44,139.194065697363,222,220,327,0.199394997832823,-2.32629887718886,3.70971143895784e-31,6.82105950758996e-30,"down","yes","PPFIA4","protein_coding","chr1:203026498-203078740:+","gi|747811820|ref|NP_001291260.1|",5515,0,"liprin-alpha-4 isoform 1 [Homo sapiens]","gi|795343155|ref|XM_011746690.1|",5785,0,"PREDICTED: Macaca nemestrina protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 (PPFIA4), transcript variant X14, mRNA","O75335",1990,0,"Liprin-alpha-4",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.",".","GO:0009986|cell surface;GO:0005829|cytosol;GO:0005622|intracellular;GO:0048786|presynaptic active zone;GO:0045202|synapse;",".",".","."]
["ENSG00000187688",1,2,6,9.97676878795184,13,18,25,0.196202742441413,-2.34958288779007,0.00131552908878031,0.00420446148540092,"down","yes","TRPV2","protein_coding","chr17:16415542-16437003:+","gi|20127551|ref|NP_057197.2|",3696,0,"transient receptor potential cation channel subfamily V member 2 [Homo sapiens]","gi|302148506|ref|NM_016113.4|",2808,0,"Homo sapiens transient receptor potential cation channel subfamily V member 2 (TRPV2), mRNA","Q9Y5S1",1424,0,"Transient receptor potential cation channel subfamily V member 2","TP0835",53.5,3e-06,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0070588|calcium ion transmembrane transport;GO:0045773|positive regulation of axon extension;GO:0090280|positive regulation of calcium ion import;GO:0009408|response to heat;GO:0009266|response to temperature stimulus;GO:0007600|sensory perception;","GO:0044295|axonal growth cone;GO:0044297|cell body;GO:0009986|cell surface;GO:0032584|growth cone membrane;GO:0005887|integral component of plasma membrane;GO:0042470|melanosome;GO:0005886|plasma membrane;","GO:0005262|calcium channel activity;GO:0005261|cation channel activity;GO:0005216|ion channel activity;GO:0015075|ion transmembrane transporter activity;","K04971","TRPV2; transient receptor potential cation channel subfamily V member 2"]
["ENSG00000157087",6,4,3,14.1964647721104,16,28,37,0.194165661856262,-2.36464001179218,8.3274337403883e-05,0.000320789978000019,"down","yes","ATP2B2","protein_coding","chr3:10324023-10708007:-","gi|767923365|ref|XP_011532060.1|",5611,0,"PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X7 [Homo sapiens]","gi|767923366|ref|XM_011533759.1|",5104,0,"PREDICTED: Homo sapiens ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant X11, mRNA","Q9R0K7",2051,0,"Plasma membrane calcium-transporting ATPase 2",".",".",".",".","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0060088|auditory receptor cell stereocilium organization;GO:1901660|calcium ion export;GO:0006816|calcium ion transport;GO:0000902|cell morphogenesis;GO:0006874|cellular calcium ion homeostasis;GO:0021707|cerebellar granule cell differentiation;GO:0021702|cerebellar Purkinje cell differentiation;GO:0021692|cerebellar Purkinje cell layer morphogenesis;GO:0021549|cerebellum development;GO:0046068|cGMP metabolic process;GO:0090102|cochlea development;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0048839|inner ear development;GO:0042472|inner ear morphogenesis;GO:0060113|inner ear receptor cell differentiation;GO:0007595|lactation;GO:0040011|locomotion;GO:0007626|locomotory behavior;GO:0050885|neuromuscular process controlling balance;GO:0030182|neuron differentiation;GO:0006996|organelle organization;GO:0045299|otolith mineralization;GO:0051928|positive regulation of calcium ion transport;GO:0008361|regulation of cell size;GO:0051480|cytosolic calcium ion homeostasis;GO:0048167|regulation of synaptic plasticity;GO:0007605|sensory perception of sound;GO:0042428|serotonin metabolic process;GO:0050808|synapse organization;","GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0043025|neuronal cell body;GO:0032809|neuronal cell body membrane;GO:0005886|plasma membrane;GO:0098839|postsynaptic density membrane;","GO:0033130|acetylcholine receptor binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0030899|calcium-dependent ATPase activity;GO:0005388|calcium-transporting ATPase activity;GO:0005516|calmodulin binding;GO:0035254|glutamate receptor binding;GO:0030165|PDZ domain binding;GO:0008022|protein C-terminus binding;","K05850","ATP2B; Ca2+ transporting ATPase, plasma membrane [EC:3.6.3.8]"]
["ENSG00000102760",3,15,9,30.3394968401769,57,48,59,0.193238531829514,-2.37154529814283,1.03557577415962e-07,5.56694134113455e-07,"down","yes","RGCC","protein_coding","chr13:41457559-41470882:+","gi|42490915|gb|AAH66334.1|",430,6e-49,"Chromosome 13 open reading frame 15 [Homo sapiens]","gi|132626810|ref|NM_014059.2|",955,0,"Homo sapiens regulator of cell cycle (RGCC), mRNA","Q9H4X1",169,3e-50,"Regulator of cell cycle RGCC",".",".",".",".","pfam15151","RGCC","Response gene to complement 32 protein family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 130 amino acids in length. There is a conserved KLGDT sequence motif.","GO:0071456|cellular response to hypoxia;GO:0006956|complement activation;GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0072537|fibroblast activation;GO:0071850|mitotic cell cycle arrest;GO:0016525|negative regulation of angiogenesis;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0008285|negative regulation of cell proliferation;GO:2000048|negative regulation of cell-cell adhesion mediated by cadherin;GO:0050710|negative regulation of cytokine secretion;GO:0001937|negative regulation of endothelial cell proliferation;GO:0001100|negative regulation of exit from mitosis;GO:0090272|negative regulation of fibroblast growth factor production;GO:1901991|negative regulation of mitotic cell cycle phase transition;GO:0071158|positive regulation of cell cycle arrest;GO:0032967|positive regulation of collagen biosynthetic process;GO:0031659|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0050715|positive regulation of cytokine secretion;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:2000573|positive regulation of DNA biosynthetic process;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:1901203|positive regulation of extracellular matrix assembly;GO:0003331|positive regulation of extracellular matrix constituent secretion;GO:0010628|positive regulation of gene expression;GO:0045840|positive regulation of mitotic nuclear division;GO:0051496|positive regulation of stress fiber assembly;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0030295|protein kinase activator activity;GO:0019901|protein kinase binding;GO:0070412|R-SMAD binding;",".","."]
["ENSG00000168497",465,439,439,1528.65870761633,2252,2810,3490,0.187281640493906,-2.41671861797934,0,0,"down","yes","CAVIN2","protein_coding","chr2:191834302-191847255:-","gi|4759082|ref|NP_004648.1|",1915,0,"serum deprivation-response protein [Homo sapiens]","gi|259089415|ref|NM_004657.5|",3226,0,"Homo sapiens serum deprivation response (SDPR), mRNA","O95810",742,0,"Caveolae-associated protein 2",".",".",".",".","pfam15237","PTRF_SDPR","PTRF/SDPR family. This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.","GO:0097320|membrane tubulation;","GO:0015629|actin cytoskeleton;GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0045121|membrane raft;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0001786|phosphatidylserine binding;GO:0005543|phospholipid binding;GO:0005080|protein kinase C binding;",".","."]
["ENSG00000182901",2,3,0,5.64804385407025,7,12,13,0.186489257800968,-2.42283556447985,0.0120582648518206,0.0315191506250055,"down","yes","RGS7","protein_coding","chr1:240775515-241357230:-","gi|156627563|ref|NP_002915.3|",2515,0,"regulator of G-protein signaling 7 isoform 1 [Homo sapiens]","gi|544346204|ref|NM_002924.5|",2491,0,"Homo sapiens regulator of G-protein signaling 7 (RGS7), transcript variant 1, mRNA","P49802",944,0,"Regulator of G-protein signaling 7",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0006457|protein folding;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0031681|G-protein beta-subunit binding;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSG00000131094",14,29,24,77.04863379911,122,131,176,0.186396153396724,-2.42355600706647,4.01936862536391e-19,4.62287310948236e-18,"down","yes","C1QL1","protein_coding","chr17:44959693-44968071:-","gi|5729785|ref|NP_006679.1|",928,2e-120,"C1q-related factor precursor [Homo sapiens]","gi|747165356|ref|NM_006688.4|",1295,0,"Homo sapiens complement component 1, q subcomponent-like 1 (C1QL1), mRNA","O75973",362,5e-122,"C1q-related factor",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0007626|locomotory behavior;GO:0016322|neuron remodeling;","GO:0044301|climbing fiber;GO:0005581|collagen trimer;GO:0005737|cytoplasm;GO:0098793|presynapse;GO:0043083|synaptic cleft;","GO:0005102|receptor binding;",".","."]
["ENSG00000255198",1,2,1,4.66921531381957,7,5,15,0.180991668445707,-2.46600480735077,0.0202431605817941,0.0497135321239679,"down","yes","SNHG9","lincRNA","chr16:1964959-1965509:+","gi|20380214|gb|AAH28232.1|",158,6e-12,"Unknown (protein for IMAGE:5221276), partial [Homo sapiens]","gi|551882069|tpe|HG507603.1|",471,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000434028.1 (SNHG9 gene), lincRNA",".",".",".",".",".",".",".",".","pfam09483","HpaP","Type III secretion protein (HpaP). This entry represents proteins encoded by genes which are always found in type III secretion operons, although their function in the processes of secretion and virulence is unclear. Hpa stands for Hrp-associated gene, where Hrp stands for hypersensitivity response and virulence. see also PMID:18584024",".",".",".",".","."]
["ENSG00000189057",108,98,108,369.545370152859,565,687,818,0.18028826130429,-2.47162262994967,9.63442952459313e-93,5.73545915649235e-91,"down","yes","FAM111B","protein_coding","chr11:59107185-59127410:+","gi|39573718|ref|NP_945185.1|",3985,0,"protein FAM111B isoform a [Homo sapiens]","gi|218156271|ref|NM_198947.3|",3488,0,"Homo sapiens family with sequence similarity 111 member B (FAM111B), transcript variant 1, mRNA",".",".",".",".",".",".",".",".","pfam13365","Trypsin_2","Trypsin-like peptidase domain. This family includes trypsin like peptidase domains.",".",".",".",".","."]
["ENSG00000106178",2,4,2,9.39131413892753,10,21,23,0.179791778866039,-2.47560104100029,0.000975412992649449,0.00319907597385182,"down","yes","CCL24","protein_coding","chr7:75811665-75823356:-","gi|22165427|ref|NP_002982.2|",626,2e-80,"C-C motif chemokine 24 precursor [Homo sapiens]","gi|767948426|ref|XM_011516459.1|",585,0,"PREDICTED: Homo sapiens chemokine (C-C motif) ligand 24 (CCL24), transcript variant X1, mRNA","O00175",245,7e-82,"C-C motif chemokine 24",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0007267|cell-cell signaling;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0007010|cytoskeleton organization;GO:0048245|eosinophil chemotaxis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0048247|lymphocyte chemotaxis;GO:0002548|monocyte chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0030838|positive regulation of actin filament polymerization;GO:0045766|positive regulation of angiogenesis;GO:0030335|positive regulation of cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:2000418|positive regulation of eosinophil migration;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0043547|positive regulation of GTPase activity;GO:0050729|positive regulation of inflammatory response;GO:0008360|regulation of cell shape;GO:0007165|signal transduction;","GO:0005615|extracellular space;","GO:0031728|CCR3 chemokine receptor binding;GO:0008009|chemokine activity;GO:0048018|receptor agonist activity;",".","."]
["ENSG00000118513",12,10,13,41.4746725731015,72,69,89,0.179471990443511,-2.47816938956518,5.01713723634244e-12,3.87702496051975e-11,"down","yes","MYB","protein_coding","chr6:135181315-135219173:+","gi|194328729|ref|NP_001123645.1|",3740,0,"transcriptional activator Myb isoform 1 [Homo sapiens]","gi|194328728|ref|NM_001130173.1|",3672,0,"Homo sapiens MYB proto-oncogene, transcription factor (MYB), transcript variant 1, mRNA","P10242",771,0,"Transcriptional activator Myb","ECU11g1690",154,1e-40,"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0070301|cellular response to hydrogen peroxide;GO:0071300|cellular response to retinoic acid;GO:0006338|chromatin remodeling;GO:0000278|mitotic cell cycle;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032967|positive regulation of collagen biosynthetic process;GO:0060252|positive regulation of glial cell proliferation;GO:2000491|positive regulation of hepatic stellate cell activation;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0043525|positive regulation of neuron apoptotic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045624|positive regulation of T-helper cell differentiation;GO:2000845|positive regulation of testosterone secretion;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0071636|positive regulation of transforming growth factor beta production;GO:1902036|regulation of hematopoietic stem cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0001666|response to hypoxia;","GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135|transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09420","MYB; myb proto-oncogene protein"]
["ENSG00000108387",3,3,6,14.379235720456,25,27,27,0.178603410011784,-2.48516846929874,4.67880474409454e-05,0.000186687600132593,"down","yes","2020-09-04","protein_coding","chr17:58520250-58540818:-","gi|16506115|dbj|BAB70694.1|",751,2e-88,"Bradeion alpha [Homo sapiens]","gi|34533184|dbj|AK126631.1|",3499,0,"Homo sapiens cDNA FLJ44671 fis, clone BRACE3005989","O43236",173,2e-44,"Septin-4","SPAC4F10.11",70.1,2e-11,"COG5019","pfam00735","Septin","Septin. Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.","GO:0006915|apoptotic process;GO:0007420|brain development;GO:0007049|cell cycle;GO:0051301|cell division;GO:0043065|positive regulation of apoptotic process;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;GO:0031398|positive regulation of protein ubiquitination;GO:0051260|protein homooligomerization;GO:0042981|regulation of apoptotic process;GO:0048240|sperm capacitation;GO:0030382|sperm mitochondrion organization;","GO:0005739|mitochondrion;GO:0043209|myelin sheath;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0031105|septin complex;GO:0097227|sperm annulus;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0000287|magnesium ion binding;GO:0042803|protein homodimerization activity;GO:0005198|structural molecule activity;","K16943","SEPT4; septin 4"]
["ENSG00000187800",53,67,57,212.187962284145,322,408,461,0.176627123408298,-2.50122119016844,4.09719952305722e-54,1.29128732680927e-52,"down","yes","PEAR1","protein_coding","chr1:156893698-156916434:+","gi|122937343|ref|NP_001073940.1|",4534,0,"platelet endothelial aggregation receptor 1 precursor [Homo sapiens]","gi|767909209|ref|XM_011509510.1|",4970,0,"PREDICTED: Homo sapiens platelet endothelial aggregation receptor 1 (PEAR1), transcript variant X5, mRNA","Q5VY43",1752,0,"Platelet endothelial aggregation receptor 1",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.","GO:0045746|negative regulation of Notch signaling pathway;GO:0043654|recognition of apoptotic cell;","GO:0016021|integral component of membrane;GO:0001891|phagocytic cup;",".",".","."]
["ENSG00000082126",76,91,54,265.061758955039,380,499,625,0.175542148164903,-2.5101106276171,9.94114887741655e-63,3.61782791599265e-61,"down","yes","MPP4","protein_coding","chr2:201644870-201698694:-","gi|296438297|sp|Q96JB8.2|MPP4_HUMAN",3257,0,"RecName: Full=MAGUK p55 subfamily member 4; AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein; AltName: Full=Discs large homolog 6","gi|188219542|ref|NM_033066.2|",2456,0,"Homo sapiens membrane protein, palmitoylated 4 (MPP4), mRNA","Q96JB8",1259,0,"MAGUK p55 subfamily member 4","YDR454c",100,1e-22,"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0035418|protein localization to synapse;","GO:0015629|actin cytoskeleton;GO:0005913|cell-cell adherens junction;GO:0005829|cytosol;GO:0032991|macromolecular complex;",".",".","."]
["ENSG00000266456",2,0,3,6.14766780186527,9,11,15,0.171566084911691,-2.54316370501923,0.00687381361039028,0.018967398700602,"down","yes","AP001178.3","antisense","chr18:650229-652843:+","gi|355756662|gb|EHH60270.1|",328,1e-32,"hypothetical protein EGM_11598, partial [Macaca fascicularis]","gi|551887045|tpe|HG509612.1|",2106,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000441200.1 (RP11-806L2.2 gene), antisense","Q6UX73",85.1,2e-24,"UPF0764 protein C16orf89",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSG00000126010",3,6,7,20.0088166641868,26,44,44,0.168760799622915,-2.56694826641939,1.01543833820146e-06,4.94590269374487e-06,"down","yes","GRPR","protein_coding","chrX:16123556-16153021:+","gi|4885361|ref|NP_005305.1|",1848,0,"gastrin-releasing peptide receptor [Homo sapiens]","gi|61677286|ref|NM_005314.2|",1929,0,"Homo sapiens gastrin releasing peptide receptor (GRPR), mRNA","P30550",716,0,"Gastrin-releasing peptide receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0008283|cell proliferation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007611|learning or memory;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0036343|psychomotor behavior;GO:0042127|regulation of cell proliferation;GO:0043207|response to external biotic stimulus;GO:0035176|social behavior;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0008528|G-protein coupled peptide receptor activity;GO:0042923|neuropeptide binding;GO:0008188|neuropeptide receptor activity;","K04169","GRPR; gastrin-releasing peptide receptor"]
["ENSG00000247151",1,2,3,7.65386499100481,7,18,20,0.164119926455464,-2.60717768203685,0.00224743776566536,0.00688181927673494,"down","yes","CSTF3-DT","processed_transcript","chr11:33161657-33191598:+","gi|685524627|ref|XP_009198893.1|",424,4e-43,"PREDICTED: 60S ribosomal protein L29 [Papio anubis]","gi|24635991|gb|AC131263.6|",2033,0,"Homo sapiens chromosome 11, clone RP11-348A11, complete sequence","P47914",135,4e-34,"60S ribosomal protein L29",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0002181|cytoplasmic translation;GO:0007566|embryo implantation;GO:0000184|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614|SRP-dependent cotranslational protein targeting to membrane;GO:0006412|translation;GO:0006413|translational initiation;","GO:0005829|cytosol;GO:0022625|cytosolic large ribosomal subunit;GO:0016020|membrane;","GO:0045296|cadherin binding;GO:0008201|heparin binding;GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;","K02905","RP-L29e, RPL29; large subunit ribosomal protein L29e"]
["ENSG00000146250",4,1,0,6.4171632659805,14,11,10,0.160585931818053,-2.63858258425708,0.00591384046264379,0.0165601270097958,"down","yes","PRSS35","protein_coding","chr6:83512538-83525704:+","gi|22713542|gb|AAH37170.1|",2002,0,"Protease, serine, 35 [Homo sapiens]","gi|281427283|ref|NM_153362.2|",2440,0,"Homo sapiens protease, serine 35 (PRSS35), transcript variant 2, mRNA","Q8N3Z0",775,0,"Inactive serine protease 35",".",".",".",".","pfam00089","Trypsin","Trypsin.",".","GO:0005576|extracellular region;",".",".","."]
["ENSG00000131153",133,86,103,416.645626710454,586,802,1015,0.160449437031582,-2.63980936723816,2.78713408741403e-99,1.81615683371763e-97,"down","yes","GINS2","protein_coding","chr16:85676198-85690073:-","gi|7706367|ref|NP_057179.1|",960,1e-120,"DNA replication complex GINS protein PSF2 [Homo sapiens]","gi|29336199|gb|AC123908.3|",2142,0,"Homo sapiens chromosome 16 clone CTD-2542L18, complete sequence","Q9Y248",374,4e-122,"DNA replication complex GINS protein PSF2","SPBC725.13c",110,3e-26,"COG5093","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0032508|DNA duplex unwinding;GO:0006271|DNA strand elongation involved in DNA replication;GO:0000727|double-strand break repair via break-induced replication;GO:1902975|mitotic DNA replication initiation;","GO:0000811|GINS complex;GO:0005654|nucleoplasm;GO:0031298|replication fork protection complex;",".","K10733","GINS2, PSF2; GINS complex subunit 2"]
["ENSG00000124491",23,24,19,87.8312618823886,134,154,219,0.155664297912127,-2.68348999909817,2.78965343144009e-26,4.34276314653885e-25,"down","yes","F13A1","protein_coding","chr6:6144085-6321013:-","gi|767939365|ref|XP_011512644.1|",4118,0,"PREDICTED: coagulation factor XIII A chain isoform X2 [Homo sapiens]","gi|694914417|ref|XM_518220.4|",3881,0,"PREDICTED: Pan troglodytes coagulation factor XIII, A1 polypeptide (F13A1), transcript variant X1, mRNA","P00488",1529,0,"Coagulation factor XIII A chain",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0007596|blood coagulation;GO:0072378|blood coagulation, fibrin clot formation;GO:0019221|cytokine-mediated signaling pathway;GO:0018149|peptide cross-linking;GO:0002576|platelet degranulation;","GO:0072562|blood microparticle;GO:0005576|extracellular region;GO:0031093|platelet alpha granule lumen;","GO:0046872|metal ion binding;GO:0003810|protein-glutamine gamma-glutamyltransferase activity;","K03917","F13A1; coagulation factor XIII A1 polypeptide [EC:2.3.2.13]"]
["ENSG00000007968",69,59,61,256.83590936756,384,469,635,0.151959408224604,-2.71824209604693,4.2587245990987e-73,1.83763490083704e-71,"down","yes","E2F2","protein_coding","chr1:23506430-23531220:-","gi|4758226|ref|NP_004082.1|",1776,0,"transcription factor E2F2 [Homo sapiens]","gi|315075284|ref|NM_004091.3|",5191,0,"Homo sapiens E2F transcription factor 2 (E2F2), mRNA","Q14209",688,0,"Transcription factor E2F2",".",".",".",".","pfam02319","E2F_TDP","E2F/DP family winged-helix DNA-binding domain. This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.","GO:0007049|cell cycle;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:1990086|lens fiber cell apoptotic process;GO:1903671|negative regulation of sprouting angiogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051726|regulation of cell cycle;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0001047|core promoter binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09389","E2F2; transcription factor E2F2"]
["ENSG00000140835",6,3,7,21.7373035051744,24,45,60,0.151481983304558,-2.7227818796897,1.70086806217369e-07,8.93905808806709e-07,"down","yes","CHST4","protein_coding","chr16:71525233-71538746:+","gi|5031735|ref|NP_005760.1|",2010,0,"carbohydrate sulfotransferase 4 [Homo sapiens]","gi|426382812|ref|XM_004057947.1|",2224,0,"PREDICTED: Gorilla gorilla gorilla carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4, transcript variant 1 (CHST4), mRNA","Q8NCG5",778,0,"Carbohydrate sulfotransferase 4",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0005975|carbohydrate metabolic process;GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0018146|keratan sulfate biosynthetic process;GO:0006044|N-acetylglucosamine metabolic process;GO:0016266|O-glycan processing;GO:0006477|protein sulfation;GO:0006790|sulfur compound metabolic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0031228|intrinsic component of Golgi membrane;GO:0005802|trans-Golgi network;","GO:0001517|N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;","K04746","CHST4; carbohydrate 6-sulfotransferase 4 [EC:2.8.2.-]"]
["ENSG00000259475",1,1,1,4.17964258834718,3,12,10,0.146675229197111,-2.76930284849746,0.0183628991991257,0.0456480989499597,"down","yes","AC036108.1","antisense","chr15:98954149-99105824:-","gi|931595838|ref|XP_003846132.3|",212,2e-16,"PREDICTED: LOW QUALITY PROTEIN: synemin [Pan paniscus]","gi|551880788|tpe|HG507516.1|",588,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000415701.1 (RP11-654A16.3 gene), antisense","O15061",61.6,7e-10,"Synemin",".",".",".",".","pfam15244","HSD3","Hydroxy-steroid dehydrogenase. This family also goes by the name of Spermatogenesis-associated protein 7 or SPAT7. It is an aldo-keto reductase (AKR) human type 3 3-alpha-hydroxy-steroid dehydrogenase (H3-alpha-HSD3, AKR1C2), and it plays a crucial role in the regulation of the intracellular concentrations of testosterone and 5-alpha-dihydrotestosterone (5-alpha-DHT), two steroids directly linked to the aetiology and the progression of many prostate diseases and cancer. Mutations in the gene cause Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP), the most common hereditary causes of visual impairment in infants and children.","GO:0031443|fast-twitch skeletal muscle fiber contraction;GO:0045104|intermediate filament cytoskeleton organization;","GO:0005912|adherens junction;GO:0043034|costamere;GO:0005882|intermediate filament;GO:0060053|neurofilament cytoskeleton;GO:0042383|sarcolemma;","GO:0019215|intermediate filament binding;GO:0005200|structural constituent of cytoskeleton;GO:0008307|structural constituent of muscle;GO:0017166|vinculin binding;","K10376","DMN; desmuslin"]
["ENSG00000113494",12,10,7,41.0312393942923,56,86,98,0.14447290560762,-2.79112913925937,1.13853903413823e-13,9.78615904209363e-13,"down","yes","PRLR","protein_coding","chr5:35048756-35230589:-","gi|820988853|ref|XP_012357164.1|",3219,0,"PREDICTED: prolactin receptor isoform X1 [Nomascus leucogenys]","gi|609877686|ref|NM_000949.6|",11688,0,"Homo sapiens prolactin receptor (PRLR), transcript variant 1, mRNA","P16471",1230,0,"Prolactin receptor",".",".",".",".","pfam09067","EpoR_lig-bind","Erythropoietin receptor, ligand binding. Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.","GO:0042976|activation of Janus kinase activity;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007166|cell surface receptor signaling pathway;GO:0007566|embryo implantation;GO:0060397|JAK-STAT cascade involved in growth hormone signaling pathway;GO:0007595|lactation;GO:0043066|negative regulation of apoptotic process;GO:0006694|steroid biosynthetic process;GO:0042110|T cell activation;","GO:0009986|cell surface;GO:0031904|endosome lumen;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0042978|ornithine decarboxylase activator activity;GO:0017046|peptide hormone binding;GO:0004925|prolactin receptor activity;GO:0042803|protein homodimerization activity;","K05081","PRLR; prolactin receptor"]
["ENSG00000198601",3,0,0,4.26575622975359,9,7,8,0.14166360345945,-2.81945894956975,0.0187350270328797,0.0464235870259743,"down","yes","OR2M2","protein_coding","chr1:248174821-248181067:+","gi|52317204|ref|NP_001004688.1|",1599,0,"olfactory receptor 2M2 [Homo sapiens]","gi|15552939|emb|AL592313.7|",1101,0,"Human DNA sequence from clone RP11-230L4 on chromosome 1, complete sequence","Q96R28",620,0,"Olfactory receptor 2M2",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0007608|sensory perception of smell;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSG00000101977",2,0,2,5.94525229085956,14,8,11,0.138823962443975,-2.84867148147186,0.00499734134807666,0.0142082429129868,"down","yes","MCF2","protein_coding","chrX:139581770-139708227:-","gi|355757753|gb|EHH61278.1|",5378,0,"hypothetical protein EGM_19250, partial [Macaca fascicularis]","gi|153791627|ref|NM_001099855.1|",3703,0,"Homo sapiens MCF.2 cell line derived transforming sequence (MCF2), transcript variant 1, mRNA","P10911",1790,0,"Proto-oncogene DBL",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0050771|negative regulation of axonogenesis;GO:0043065|positive regulation of apoptotic process;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0016020|membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["ENSG00000145861",9,2,4,22.1105189716047,25,47,61,0.136550773009269,-2.87249061371362,8.01835999869028e-08,4.36025169593285e-07,"down","yes","C1QTNF2","protein_coding","chr5:160347751-160370641:-","gi|685548644|ref|XP_009207776.1|",754,1e-89,"PREDICTED: complement C1q tumor necrosis factor-related protein 2 isoform X4 [Papio anubis]","gi|94818737|ref|NM_031908.4|",2411,0,"Homo sapiens C1q and tumor necrosis factor related protein 2 (C1QTNF2), mRNA","Q9BXJ5",294,4e-91,"Complement C1q tumor necrosis factor-related protein 2",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0000187|activation of MAPK activity;GO:0046321|positive regulation of fatty acid oxidation;GO:0046326|positive regulation of glucose import;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0070208|protein heterotrimerization;GO:0051260|protein homooligomerization;","GO:0005581|collagen trimer;GO:0005615|extracellular space;","GO:0042802|identical protein binding;GO:0005102|receptor binding;",".","."]
["ENSG00000117069",6,3,5,21.1203115849827,30,45,49,0.134695899955711,-2.89222215799648,4.85300640170965e-08,2.69676714134762e-07,"down","yes","ST6GALNAC5","protein_coding","chr1:76867441-77065711:+","gi|13569938|ref|NP_112227.1|",1759,0,"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 isoform 1 [Homo sapiens]","gi|998074880|ref|NM_030965.2|",3751,0,"Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5), transcript variant 1, mRNA","Q9BVH7",677,0,"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006688|glycosphingolipid biosynthetic process;GO:0009312|oligosaccharide biosynthetic process;GO:0009311|oligosaccharide metabolic process;GO:0018279|protein N-linked glycosylation via asparagine;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0001665|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0008373|sialyltransferase activity;","K03375","SIAT7E, ST6GalNAc V; N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7E) [EC:2.4.99.-]"]
["ENSG00000260442",1,2,0,4.63170359197604,10,8,8,0.132183450386897,-2.91938653482959,0.01104419316125,0.0290931982647077,"down","yes","ATP2A1-AS1","antisense","chr16:28878957-28879920:-","gi|685612638|ref|XP_009194478.1|",212,2e-16,"PREDICTED: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [Papio anubis]","gi|551881643|tpe|HG507897.1|",558,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000432688.1 (RP11-22P6.3 gene), antisense","P13585",65.9,3e-11,"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1",".",".",".",".","pfam00690","Cation_ATPase_N","Cation transporter/ATPase, N-terminus. Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.","GO:0006816|calcium ion transport;GO:0045988|negative regulation of striated muscle contraction;GO:0031448|positive regulation of fast-twitch skeletal muscle fiber contraction;GO:0006942|regulation of striated muscle contraction;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0031673|H zone;GO:0031674|I band;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;GO:0016529|sarcoplasmic reticulum;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0005509|calcium ion binding;GO:0005388|calcium-transporting ATPase activity;","K05853","ATP2A; Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]"]
["ENSG00000238178",4,5,0,14.011067435441,29,22,29,0.129968258821997,-2.94376876726027,1.49339741011039e-05,6.38684018762954e-05,"down","yes","AC078993.1","antisense","chrX:16152941-16170869:-","gi|426395281|ref|XP_004063903.1|",442,5e-48,"PREDICTED: melanoma-associated antigen B17-like [Gorilla gorilla gorilla]","gi|551893430|tpe|HG512451.1|",1037,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000055898.2 (RP11-431J24.2 gene), antisense",".",".",".",".",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["ENSG00000246228",2,1,2,8.25402517313723,10,22,17,0.121802351260734,-3.03738611172965,0.000503454075391747,0.00173094869984956,"down","yes","CASC8","antisense","chr8:127289817-127482139:-","gi|119612501|gb|EAW92095.1|",163,1e-10,"hCG2040402, partial [Homo sapiens]","gi|620597378|ref|NR_117100.1|",1420,0,"Homo sapiens cancer susceptibility candidate 8 (non-protein coding) (CASC8), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam13892","DBINO","DNA-binding domain. DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.",".",".",".",".","."]
["ENSG00000259349",0,2,1,5.11449521295886,9,9,12,0.119097000002066,-3.06979102204346,0.0058302950252214,0.0163499171919847,"down","yes","AC011921.1","antisense","chr17:60526293-60550798:+","gi|355754763|gb|EHH58664.1|",155,4e-11,"hypothetical protein EGM_08570, partial [Macaca fascicularis]","gi|551886013|tpe|HG509303.1|",557,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000416617.1 (RP11-15E18.1 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000257046",1,1,1,5.11379997160342,12,7,10,0.119091641444698,-3.06985593499728,0.00592957193026089,0.01659935898271,"down","yes","AC011604.2","protein_coding","chr12:20815674-21090245:+","gi|32402659|gb|AAP81212.1|",3662,0,"liver-specific organic anion transporter 3TM13 [Homo sapiens]","gi|41387887|gb|AY442326.1|",2439,0,"Homo sapiens organic anion transporter LST-3c (LST3) mRNA, complete cds","Q9NPD5",1194,0,"Solute carrier organic anion transporter family member 1B3",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0015721|bile acid and bile salt transport;GO:0015711|organic anion transport;GO:0043252|sodium-independent organic anion transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015125|bile acid transmembrane transporter activity;GO:0008514|organic anion transmembrane transporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K05043","SLCO1B; solute carrier organic anion transporter family, member 1B"]
["ENSG00000137726",0,2,0,3.74488003821154,7,7,8,0.106884367296547,-3.2258772322215,0.0167307034687808,0.0421471671673299,"down","yes","FXYD6","protein_coding","chr11:117836976-117877486:-","gi|931580153|ref|XP_014202520.1|",501,1e-56,"PREDICTED: FXYD domain-containing ion transport regulator 6 isoform X1 [Pan paniscus]","gi|323714266|ref|NM_022003.3|",2020,0,"Homo sapiens FXYD domain containing ion transport regulator 6 (FXYD6), transcript variant 1, mRNA","Q9H0Q3",196,1e-57,"FXYD domain-containing ion transport regulator 6",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0005216|ion channel activity;GO:0017080|sodium channel regulator activity;","K13363","FXYD6; FXYD domain-containing ion transport regulator 6"]
["ENSG00000172061",3,1,2,11.1344504900081,20,16,31,0.106713950972656,-3.22817929938684,3.38265977430434e-05,0.000137763390470401,"down","yes","LRRC15","protein_coding","chr3:194355247-194369743:-","gi|288541295|ref|NP_001128529.2|",2626,0,"leucine-rich repeat-containing protein 15 isoform a precursor [Homo sapiens]","gi|288541296|ref|NM_130830.4|",5883,0,"Homo sapiens leucine rich repeat containing 15 (LRRC15), transcript variant 2, mRNA","Q8TF66",1014,0,"Leucine-rich repeat-containing protein 15","SPy1798",102,7e-21,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0019221|cytokine-mediated signaling pathway;GO:0046426|negative regulation of JAK-STAT cascade;GO:0006469|negative regulation of protein kinase activity;GO:1903077|negative regulation of protein localization to plasma membrane;GO:0030335|positive regulation of cell migration;GO:0046813|receptor-mediated virion attachment to host cell;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;","GO:0005518|collagen binding;GO:0001968|fibronectin binding;GO:0043236|laminin binding;GO:0004860|protein kinase inhibitor activity;",".","."]
["ENSG00000232600",2,0,2,7.93623764238759,9,15,26,0.0985022029713736,-3.3437001994155,0.000412117282036745,0.00143560016903102,"down","yes","TONSL-AS1","antisense","chr8:144437675-144439971:+","gi|221042288|dbj|BAH12821.1|",163,1e-11,"unnamed protein product [Homo sapiens]","gi|551866413|tpe|HG501814.1|",428,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000329950.1 (AC084125.4 gene), antisense",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000178031",2,3,1,13.6459382959667,28,25,28,0.0861049338262841,-3.5377602831308,2.22492399333398e-06,1.0443984907137e-05,"down","yes","ADAMTSL1","protein_coding","chr9:17906563-18910950:+","gi|119579061|gb|EAW58657.1|",9249,0,"hCG1818607, isoform CRA_c [Homo sapiens]","gi|694929330|ref|XM_003312011.2|",7850,0,"PREDICTED: Pan troglodytes ADAMTS-like 1 (ADAMTSL1), transcript variant X1, mRNA","Q8N6G6",3566,0,"ADAMTS-like protein 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;","GO:0008233|peptidase activity;",".","."]
["ENSG00000168135",1,1,0,4.71586560360495,4,9,18,0.0806246059969306,-3.63263598461706,0.00506579625830525,0.0143774394099752,"down","yes","KCNJ4","protein_coding","chr22:38426327-38455199:-","gi|4826798|ref|NP_004972.1|",1939,0,"inward rectifier potassium channel 4 [Homo sapiens]","gi|393290855|ref|NM_152868.2|",2062,0,"Homo sapiens potassium voltage-gated channel subfamily J member 4 (KCNJ4), transcript variant 1, mRNA","P48050",751,0,"Inward rectifier potassium channel 4",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;","GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0030659|cytoplasmic vesicle membrane;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015467|G-protein activated inward rectifier potassium channel activity;GO:0005242|inward rectifier potassium channel activity;GO:0030165|PDZ domain binding;","K04998","KCNJ4; potassium inwardly-rectifying channel subfamily J member 4"]
["ENSG00000277531",0,1,1,4.93335129386783,9,9,12,0.0793729094655308,-3.65520950040009,0.00377208546203809,0.0110119546529122,"down","yes","PNMA8C","protein_coding","chr19:46424697-46428951:-","gi|928124840|ref|XP_013972061.1|",1068,4e-128,"PREDICTED: uncharacterized protein LOC612190 [Canis lupus familiaris]","gi|9211222|gb|AC024584.5|",4255,0,"Homo sapiens chromosome 19 clone LLNLF-187D8, complete sequence",".",".",".",".",".",".",".",".","pfam14893","PNMA","PNMA. The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.",".",".",".",".","."]
["ENSG00000139973",0,0,2,4.97812067966592,10,8,12,0.0792923191182182,-3.6566750679406,0.00409609140894383,0.0118502191533986,"down","yes","SYT16","protein_coding","chr14:61811974-62112550:+","gi|123173752|ref|NP_114120.2|",3198,0,"synaptotagmin-16 [Homo sapiens]","gi|14625742|emb|AL390816.4|",12158,0,"Human chromosome 14 DNA sequence BAC R-355I22 of library RPCI-11 from chromosome 14 of Homo sapiens (Human), complete sequence","Q17RD7",1219,0,"Synaptotagmin-16",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0006887|exocytosis;GO:0006906|vesicle fusion;","GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0030276|clathrin binding;GO:0005543|phospholipid binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0019905|syntaxin binding;","K19328","SYT14_16; synaptotagmin-14/16"]
["ENSG00000250282",0,1,0,2.64069948254244,6,3,7,0.0789406023964791,-3.66308866128228,0.0200709918352684,0.049322116259225,"down","yes","AC002401.2","antisense","chr17:50100704-50101920:-",".",".",".",".","gi|551886083|tpe|HG509223.1|",430,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000366660.1 (RP5-875H18.4 gene), antisense",".",".",".",".",".",".",".",".","pfam10225","DUF2215","Uncharacterized conserved protein (DUF2215). This entry is the central 200 residues of a family of proteins conserved from worms to humans. The function is unknown.",".",".",".",".","."]
["ENSG00000239620",0,1,0,2.7290912059072,5,4,8,0.0757600708376177,-3.72241851001077,0.0167402858182484,0.0421633106375522,"down","yes","PRR20G","protein_coding","chr3:127283784-127288046:-","gi|397488515|ref|XP_003815305.1|",713,9e-90,"PREDICTED: proline-rich protein 20A-like [Pan paniscus]","gi|675732245|ref|XM_003815257.2|",866,0,"PREDICTED: Pan paniscus proline-rich protein 20A-like (LOC100973511), mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSG00000275632",1,0,0,2.74477648448799,5,5,7,0.0750824117700342,-3.73538119713411,0.0159403838304972,0.0404284185828573,"down","yes","AL035461.2","lincRNA","chr20:6000418-6000941:+","gi|694919214|ref|XP_009450650.1|",187,6e-15,"PREDICTED: protein GVQW1-like [Pan troglodytes]","gi|666670973|tpe|LK937880.1|",524,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000473465.1 (RP5-967N21.11 gene), lincRNA","Q6B4Z3",66.2,2e-11,"Histone demethylase UTY",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0010468|regulation of gene expression;","GO:0005634|nucleus;","GO:0051213|dioxygenase activity;GO:0071558|histone demethylase activity (H3-K27 specific);GO:0046872|metal ion binding;","K11447","UTX, UTY; histone demethylase [EC:1.14.11.-]"]
["ENSG00000197153",0,1,0,2.8049751214411,9,2,5,0.0749159137026291,-3.7385839800193,0.0187706388859951,0.0464760054984691,"down","yes","HIST1H3J","protein_coding","chr6:27890382-27893106:-","gi|795350796|ref|XP_011931511.1|",591,1e-83,"PREDICTED: uncharacterized protein LOC105593202 [Cercocebus atys]","gi|694915111|ref|XM_009450704.1|",510,0,"PREDICTED: Pan troglodytes histone H2A type 1-like (LOC471909), mRNA","P0C0S8",229,8e-76,"Histone H2A type 1","SPAC19G12.06c",190,9e-61,"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006342|chromatin silencing;","GO:0070062|extracellular exosome;GO:0000790|nuclear chromatin;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0019899|enzyme binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["ENSG00000235781",1,0,0,2.78078208620226,6,4,7,0.0743015170377376,-3.75046452274601,0.0156242990373604,0.0397050698066677,"down","yes","LINC02569","antisense","chr6:30516266-30519217:+","gi|119623698|gb|EAX03293.1|",336,3e-36,"hCG2040862, partial [Homo sapiens]","gi|551858975|tpe|HG499122.1|",851,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000256179.1 (XXbac-BPG249D20.9 gene), antisense",".",".",".",".",".",".",".",".","pfam10271","Tmp39","Putative transmembrane protein. This is a family of conserved proteins found from worms to humans. They are putative transmembrane proteins but the function is unknown.",".",".",".",".","."]
["ENSG00000077274",2,0,1,7.95809855551609,22,15,8,0.0732778860001893,-3.77047830616841,0.000418851497848836,0.00145826853619284,"down","yes","CAPN6","protein_coding","chrX:111245103-111270523:-","gi|13186316|ref|NP_055104.2|",3466,0,"calpain-6 [Homo sapiens]","gi|268607640|ref|NM_014289.3|",3565,0,"Homo sapiens calpain 6 (CAPN6), mRNA","Q9Y6Q1",1339,0,"Calpain-6",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0001578|microtubule bundle formation;GO:0006508|proteolysis;GO:0051493|regulation of cytoskeleton organization;","GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;GO:0005876|spindle microtubule;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0008017|microtubule binding;","K08575","CAPN6; calpain-6 [EC:3.4.22.-]"]
["ENSG00000225721",0,1,0,2.99813908810684,4,7,8,0.0682923218659635,-3.87213280494284,0.011061116268846,0.0291258444496249,"down","yes","AL592166.1","antisense","chr1:44759037-44775810:-","gi|530667169|gb|EQB77470.1|",239,4e-20,"kinesin family member 2C isoform 2 [Camelus ferus]","gi|551896162|tpe|HG491983.1|",580,0,"TPA: Homo sapiens long non-coding RNA OTTHUMT00000023427.1 (RP11-269F19.2 gene), antisense","Q95LP1",91.7,6e-20,"Kinesin-like protein KIF2C",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.","GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051301|cell division;GO:0051310|metaphase plate congression;GO:0007018|microtubule-based movement;GO:0007080|mitotic metaphase plate congression;","GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0000776|kinetochore;GO:0035371|microtubule plus-end;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003777|microtubule motor activity;GO:0051010|microtubule plus-end binding;","K10393","KIF2_24, MCAK; kinesin family member 2/24"]
["ENSG00000196415",1,1,0,5.61451477478481,10,14,10,0.0682451623839403,-3.87312940677603,0.0018582517499697,0.00578843019273508,"down","yes","PRTN3","protein_coding","chr19:840960-848175:+","gi|71361688|ref|NP_002768.3|",1257,1e-171,"myeloblastin precursor [Homo sapiens]","gi|295980852|emb|FN647680.1|",1030,0,"Homo sapiens mRNA for proteinase 3 (PRTN3 gene)","P24158",488,4e-173,"Myeloblastin","VC1200",81.3,3e-16,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0019730|antimicrobial humoral response;GO:0007596|blood coagulation;GO:0045217|cell-cell junction maintenance;GO:0030574|collagen catabolic process;GO:0019221|cytokine-mediated signaling pathway;GO:0097029|mature conventional dendritic cell differentiation;GO:0006509|membrane protein ectodomain proteolysis;GO:0050765|negative regulation of phagocytosis;GO:0043312|neutrophil degranulation;GO:0072672|neutrophil extravasation;GO:0008284|positive regulation of cell proliferation;GO:0043547|positive regulation of GTPase activity;GO:0006508|proteolysis;","GO:0035578|azurophil granule lumen;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0044853|plasma membrane raft;","GO:0019899|enzyme binding;GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;GO:0005102|receptor binding;","K01350","PRTN3; myeloblastin [EC:3.4.21.76]"]
["ENSG00000188163",0,1,0,3.16628743911085,9,6,3,0.0659126062691776,-3.92330177214812,0.0109812224987711,0.028931268891722,"down","yes","FAM166A","protein_coding","chr9:137243584-137247770:-","gi|767957470|ref|XP_011516998.1|",1397,0,"PREDICTED: protein FAM166A isoform X3 [Homo sapiens]","gi|21757169|dbj|AK097419.1|",1717,0,"Homo sapiens cDNA FLJ40100 fis, clone TESTI2004675","Q6J272",424,4e-143,"Protein FAM166A",".",".",".",".","pfam10629","DUF2475","Protein of unknown function (DUF2475). This family of proteins has no known function.",".","GO:0005634|nucleus;",".",".","."]
["ENSG00000171388",9,15,17,130.671230384784,237,262,310,0.0600024292858796,-4.05883527825784,4.78472144408448e-50,1.38362379630437e-48,"down","yes","APLN","protein_coding","chrX:129645259-129654937:-","gi|119632233|gb|EAX11828.1|",663,1e-77,"apelin, AGTRL1 ligand, isoform CRA_a [Homo sapiens]","gi|290645488|ref|NM_017413.4|",3205,0,"Homo sapiens apelin (APLN), mRNA","Q9ULZ1",100,3e-23,"Apelin",".",".",".",".","pfam15360","Apelin","APJ endogenous ligand. Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes. It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis.","GO:0001525|angiogenesis;GO:0060183|apelin receptor signaling pathway;GO:0060976|coronary vasculature development;GO:0042756|drinking behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007369|gastrulation;GO:0006955|immune response;GO:0007595|lactation;GO:0045776|negative regulation of blood pressure;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0010629|negative regulation of gene expression;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:0045906|negative regulation of vasoconstriction;GO:0051461|positive regulation of corticotropin secretion;GO:0051466|positive regulation of corticotropin-releasing hormone secretion;GO:1904022|positive regulation of G-protein coupled receptor internalization;GO:0045823|positive regulation of heart contraction;GO:0031652|positive regulation of heat generation;GO:0042327|positive regulation of phosphorylation;GO:1902895|positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:0043576|regulation of respiratory gaseous exchange;GO:0002026|regulation of the force of heart contraction;GO:0007165|signal transduction;GO:0023052|signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0048471|perinuclear region of cytoplasm;","GO:0031704|apelin receptor binding;GO:0001664|G-protein coupled receptor binding;GO:0005179|hormone activity;GO:0005102|receptor binding;","K05225","APLN; apelin"]
["ENSG00000263080",1,1,0,6.3843965191424,16,10,12,0.0599102783332417,-4.06105265373363,0.000949089259085645,0.00312229807764692,"down","yes","AC009121.2","antisense","chr16:11341809-11345211:-",".",".",".",".","gi|995970222|ref|NR_135174.1|",714,0,"Homo sapiens uncharacterized LOC105371083 (LOC105371083), long non-coding RNA",".",".",".",".",".",".",".",".","pfam02489","Herpes_glycop_H","Herpesvirus glycoprotein H. Herpesvirus glycoprotein H (gH) is a virion associated envelope glycoprotein. Complex formation between gH and gL has been demonstrated in both virions and infected cells.",".",".",".",".","."]
["ENSG00000179869",0,0,1,3.45597876296165,8,5,8,0.059570327705468,-4.06926229418572,0.00631037054969736,0.017574859414717,"down","yes","ABCA13","protein_coding","chr7:48171458-48647496:+","gi|597709765|ref|NP_689914.3|",26017,0,"ATP-binding cassette sub-family A member 13 [Homo sapiens]","gi|597709764|ref|NM_152701.4|",17184,0,"Homo sapiens ATP binding cassette subfamily A member 13 (ABCA13), mRNA","Q86UQ4",9994,0,"ATP-binding cassette sub-family A member 13",".",".",".",".","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;GO:0043312|neutrophil degranulation;","GO:0035577|azurophil granule membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05647","ABCA13; ATP binding cassette, subfamily A (ABC1), member 13"]
["ENSG00000251169",2,0,0,6.43284283759563,10,17,13,0.0584007731405851,-4.09786872137654,0.000853953459149132,0.00282764881031218,"down","yes","LINC01843","lincRNA","chr5:134506552-134509229:+","gi|21758970|dbj|BAC05428.1|",208,2e-16,"unnamed protein product [Homo sapiens]","gi|560879489|ref|NR_105045.1|",1107,0,"Homo sapiens uncharacterized LOC101927934 (LOC101927934), long non-coding RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSG00000203756",0,0,1,3.58037608804068,8,5,9,0.0572776074954693,-4.12588495776105,0.00531039800005173,0.0150230209188909,"down","yes","TMEM244","protein_coding","chr6:129831244-129861547:-","gi|58197570|ref|NP_001010876.1|",654,1e-84,"transmembrane protein 244 [Homo sapiens]","gi|694918241|ref|XM_009451981.1|",537,0,"PREDICTED: Pan troglodytes transmembrane protein 244 (TMEM244), transcript variant X2, mRNA","Q5VVB8",256,3e-86,"Transmembrane protein 244",".",".",".",".","pfam09801","SYS1","Integral membrane protein S linking to the trans Golgi network. Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSG00000176912",2,0,0,7.17922678806981,10,17,19,0.0518373645070603,-4.269863818567,0.000399154692533027,0.00139371754337021,"down","yes","TYMSOS","bidirectional_promoter_lncRNA","chr18:641320-658340:-","gi|119622128|gb|EAX01723.1|",472,6e-56,"chromosome 18 open reading frame 56 [Homo sapiens]","gi|270265903|ref|NM_001012716.2|",844,0,"Homo sapiens TYMS opposite strand (TYMSOS), mRNA",".",".",".",".",".",".",".",".","pfam00303","Thymidylat_synt","Thymidylate synthase.",".",".",".",".","."]
["ENSG00000189068",1,0,0,4.41482522180378,1,16,13,0.0449446107025052,-4.47570805688054,0.00272315630421698,0.00820434845294238,"down","yes","VSTM1","protein_coding","chr19:54040825-54063953:-","gi|37182207|gb|AAQ88906.1|",619,2e-87,"LAIR hlog [Homo sapiens]","gi|441626717|ref|XM_003259747.2|",845,0,"PREDICTED: Nomascus leucogenys V-set and transmembrane domain containing 1 (VSTM1), mRNA","Q6UX27",243,2e-88,"V-set and transmembrane domain-containing protein 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002376|immune system process;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0005125|cytokine activity;",".","."]
["ENSG00000185269",0,0,0,2.39929325696458,7,3,5,0.0418315722758982,-4.57926396583025,0.00508672307183999,0.0144325852617902,"down","yes","NOTUM","protein_coding","chr17:81952507-81961840:-","gi|194394139|ref|NP_848588.3|",2321,0,"palmitoleoyl-protein carboxylesterase NOTUM precursor [Homo sapiens]","gi|194394138|ref|NM_178493.5|",2217,0,"Homo sapiens notum pectinacetylesterase homolog (Drosophila) (NOTUM), mRNA","Q6P988",898,0,"Palmitoleoyl-protein carboxylesterase NOTUM",".",".",".",".","pfam03283","PAE","Pectinacetylesterase.","GO:0044267|cellular protein metabolic process;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0043687|post-translational protein modification;GO:1990697|protein depalmitoleylation;GO:0016055|Wnt signaling pathway;","GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;","GO:1990699|palmitoleyl hydrolase activity;GO:0004629|phospholipase C activity;",".","."]
["ENSG00000170373",0,4,3,36.6333726797991,66,71,97,0.0356913047596718,-4.8082835471185,4.68677122606729e-15,4.37764859120513e-14,"down","yes","CST1","protein_coding","chr20:23747553-23751268:-","gi|337752|gb|AAA60299.1|",669,1e-85,"cystatin precursor [Homo sapiens]","gi|19882250|ref|NM_001898.2|",760,0,"Homo sapiens cystatin SN (CST1), mRNA","P01037",259,6e-86,"Cystatin-SN",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:2000117|negative regulation of cysteine-type endopeptidase activity;","GO:0005615|extracellular space;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0002020|protease binding;","K13897","CST1; cystatin-SN"]
["ENSG00000138271",0,0,0,3.29870133903361,5,13,3,0.0302246939677793,-5.04812845785706,0.00115857972766187,0.00374255160263898,"down","yes","GPR87","protein_coding","chr3:151294086-151316952:-","gi|224586796|ref|NP_076404.3|",1892,0,"G-protein coupled receptor 87 [Homo sapiens]","gi|821006177|ref|XM_003256298.2|",1509,0,"PREDICTED: Nomascus leucogenys G protein-coupled receptor 87 (GPR87), mRNA","Q9BY21",733,0,"G-protein coupled receptor 87",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007194|negative regulation of adenylate cyclase activity;","GO:0005887|integral component of plasma membrane;","GO:0045028|G-protein coupled purinergic nucleotide receptor activity;","K08389","GPR87; G protein-coupled receptor 87"]
["ENSG00000101441",1,2,1,28.4929009426614,44,60,83,0.0257816273826295,-5.27751285769857,2.09748487683025e-11,1.5614159901313e-10,"down","yes","CST4","protein_coding","chr20:23685640-23689040:-","gi|4503109|ref|NP_001890.1|",661,2e-84,"cystatin-S precursor [Homo sapiens]","gi|41350859|gb|BC065714.1|",750,0,"Homo sapiens cystatin S, mRNA (cDNA clone MGC:71923 IMAGE:30327736), complete cds","P01036",259,6e-86,"Cystatin-S",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:2000117|negative regulation of cysteine-type endopeptidase activity;GO:0045861|negative regulation of proteolysis;GO:0001895|retina homeostasis;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0002020|protease binding;","K13900","CST4; cystatin-S"]
["ENSG00000107159",1,1,1,22.9675651894179,32,61,57,0.0239610024327852,-5.38316792377841,3.04005146532145e-09,1.87937540586923e-08,"down","yes","CA9","protein_coding","chr9:35673856-35681159:+","gi|169636420|ref|NP_001207.2|",1842,0,"carbonic anhydrase 9 precursor [Homo sapiens]","gi|15928967|gb|BC014950.1|",1612,0,"Homo sapiens carbonic anhydrase IX, mRNA (cDNA clone MGC:22967 IMAGE:4865275), complete cds","Q16790",714,0,"Carbonic anhydrase 9","mll6384",99,3e-22,"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0015701|bicarbonate transport;GO:0002009|morphogenesis of an epithelium;GO:0061418|regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0042493|response to drug;GO:0033574|response to testosterone;GO:0046903|secretion;","GO:0016323|basolateral plasma membrane;GO:0016021|integral component of membrane;GO:0031528|microvillus membrane;GO:0005730|nucleolus;GO:0005886|plasma membrane;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;","K01672","E4.2.1.1; carbonic anhydrase [EC:4.2.1.1]"]
["ENSG00000201699",0,0,0,4.85160078584318,7,15,10,0.0204431071785725,-5.61224169944667,7.48215043430838e-05,0.000290081844375759,"down","yes","RNU1-59P","snRNA","chr1:149162783-149162944:-",".",".",".",".","gi|937347144|ref|NG_043231.1|",162,3e-78,"Homo sapiens RNA, U1 small nuclear 59, pseudogene (RNU1-59P) on chromosome 1",".",".",".",".",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).",".",".",".",".","."]