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Caption : fig s1. synthesis of cdm.

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Caption : fig s2. synthesis of lnd-tpp.

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Caption : fig s3. characterization of cdm.
a. tlc results of cdm after reaction (stationary phase: silica gf254, mobile phase: dcm/ammonia 4% in meoh/tea = 92:8:2.5); b. absorption and emission spectra of cdm in pbs solution containing bsa 10 mg/ml and dmso 10%; c. mass spectroscopy of cdm.


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Caption : fig s4. characterization of lnd-tpp.
a. tlc results of lnd-tpp after reaction (stationary phase: silica gf254, mobile phase: dcm:meoh:tea = 100:5:1); b. uv absorption spectra of lnd-tpp; c. mass spectroscopy of lnd-tpp.


File Name : fig s5.tif

Caption : cytotoxicity of lnd-tpp, cdm, ir780, and their combination on 4t1 cancer cells.

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Caption : fig s6. cytotoxicity of tpplnd and cdm after mild-hyperthermia treatment.

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Caption : intratumor atp level of 4t1-bearing mice.

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Caption : body weight graph of mice during treatment.

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Caption : histological observation of main organs including heart, lung, liver, spleen, and kidney of mice sacrificed after 21 days of different treatments. the scale bars were 200 μm.