{"text_format":"2","workbook":"xls","n_sheets":5,"sheets":["ReadMe","Summary","Expressed both samples","Expressed only Sample_1","Expressed only Sample_3"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"ReadMe","index":0,"n_rows":25,"n_cols":2,"rows_kept":25,"cut":false,"hidden":false,"merged":[[5,0,5,1],[12,0,12,1],[26,0,26,2]],"flags":["formulas_cached_only"]}
[]
["Sample 1: Cells in 2D, Growth medium"]
["Sample 3: Cells in 3D, Growth medium"]
[]
[]
["Description of the worksheets"]
["ReadMe","Current Sheet"]
["Summary","Summary of the project and workflow"]
["Expressed both samples","Expression of miRNAs in both the samples"]
["Expressed only Sample 1","miRNA's expressed only in Sample 1"]
["Expressed only Sample 3","miRNA's expressed only in Sample 3"]
[]
["Description of columns in the worksheets"]
["miRNA (Subject)","Predicted Novel miRNA sequence"]
["Sample_1 Expression","miRNA expression in Sample_1"]
["Sample_3 Expression","miRNA expression in Sample_3"]
["FoldChange","Fold change of expression value"]
["log2FoldChange*","Log value of fold change"]
["P Value","P Value of expression"]
["Adjusted P Value","Adjusted P Value of expression"]
["Regulation","Regulation of miRNA (Up, Down or Neutral)"]
["Accession","miRNA Accession"]
[]
["* log2FoldChange>1= UP"]
["*log2FoldChange<-1 = DOWN"]

{"sheet":"Summary","index":1,"n_rows":9,"n_cols":5,"rows_kept":9,"cut":false,"hidden":false,"merged":[[0,0,0,4]],"flags":["formulas_cached_only"]}
["DGE Statistics"]
["No. of miRNAin each category for Sample 1 and Sample 3","Total","Up","Down","Neutral"]
["No. of miRNA expressed in both samples",11,0,3,8]
["No. of miRNA expressed only in Sample 1",73,"NA","NA","NA"]
["No. of miRNA expressed only in Sample 3",70,"NA","NA","NA"]
[]
["Software used for carrying out DGE","DeSeq"]
["Sample taken as control for DGE","Sample 1"]
["Sample taken as treated for DGE","Sample 3"]

{"sheet":"Expressed both samples","index":2,"n_rows":12,"n_cols":8,"rows_kept":12,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["miRNA","Sample_1 Expression","Sample_3 Expression","FoldChange","log2FoldChange","P Value","Adjusted P Value","Regulation"]
["ACGGGCGCGCGGGGTCTCTCCGCG",3.96862696659689,3.02371578407382,0.7619047619047621,-0.39231742277875997,1,1,"NEUTRAL"]
["AAAGAGGAACAGCTCTTTACCTT",5.29150262212918,9.07114735222145,1.71428571428571,0.777607578663552,0.926620274547283,1,"NEUTRAL"]
["TCTTGTAGCAGGTATTTTCCCTG",5.29150262212918,5.29150262212918,1,0,1,1,"NEUTRAL"]
["GTTTCCTTTCTGCTCTGACCTGAC",6.61437827766148,5.29150262212918,0.8,-0.321928094887363,0.9876869731094631,1,"NEUTRAL"]
["GCCCCGGGCCCTCGACCGGACCGG",5.29150262212918,6.04743156814764,1.14285714285714,0.19264507794239602,1,1,"NEUTRAL"]
["GTCCCCAGACTCTCCCGGGCTGTG",13.228756555323,13.6067210283322,1.02857142857143,0.0406419844973458,1,1,"NEUTRAL"]
["TCACCGACTCTGCCCGTCCCAGGT",5.29150262212918,6.80336051416609,1.28571428571429,0.36257007938470803,0.9921376200343651,1,"NEUTRAL"]
["AGTCCATTTCAAGTTAACTCTGT",6.61437827766148,7.55928946018454,1.14285714285714,0.19264507794239602,1,1,"NEUTRAL"]
["GTCTGGGCCAACCCTTCCATGGGT",6.61437827766148,2.26778683805536,0.342857142857143,-1.54432051622381,0.8734580645349561,0.962961690776956,"DOWN"]
["ATATGTGTGTGTGCTTGTATATA",9.26012958872607,4.53557367611073,0.48979591836734704,-1.02974734339405,0.8786751512174661,0.962961690776956,"DOWN"]
["TCCCCTCCTGGCTGGCTCGCCA",17.1973835219198,2.26778683805536,0.131868131868132,-2.92283213947754,0.630404056135152,0.9279028588202761,"DOWN"]

{"sheet":"Expressed only Sample_1","index":3,"n_rows":74,"n_cols":4,"rows_kept":74,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["miRNA","Sample_1 Expression","P Value","Adjusted P Value"]
["CTCACGGCTGTGCCTCCCACAGC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["TGTCCCTGTTTGGGCGCCAC",6.61437827766148,0.7710368376932121,0.9279028588202761]
["AAAGAACCAAGAATGGGCTGCCCT",13.228756555323,0.417335928145843,0.9279028588202761]
["GTCGGGCGGGCGGTCGGGCCGGC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["ACTAGGTCGGTGCAAAAGTCATC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["GAGAGATCAGAGGCGCAGAGTGC",17.1973835219198,0.37909403932556,0.9279028588202761]
["TTGGTTTTGTTTGGGTTTGTT",5.29150262212918,0.7813139724735471,0.9279028588202761]
["TACAGAAGACTGCACATTTGTAT",5.29150262212918,0.7813139724735471,0.9279028588202761]
["TATTTTGAGCTCTGCATCTTAAC",1.3228756555323,0.797337328146125,0.9279028588202761]
["GAGGGGCGGCGGCGGCGGCGGC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CTAGTTTTATATTTTTGAGCCCT",3.96862696659689,0.7555093256130011,0.9279028588202761]
["GCCCGCGAGGGGTCGCCGCCC",5.29150262212918,0.7813139724735471,0.9279028588202761]
["CCCGCGGGGCCGGAGGAGCCT",9.26012958872607,0.555666568833184,0.9279028588202761]
["GTGAGGTTGTAGGTTGTTTGGTTT",5.29150262212918,0.7813139724735471,0.9279028588202761]
["GCAAGGCCGGGCCTGGCGGGG",5.29150262212918,0.7813139724735471,0.9279028588202761]
["CCCGCCGCCCCTCCTCCTCCC",9.26012958872607,0.555666568833184,0.9279028588202761]
["GAAGTTGCCCGTGTTTTTTTCG",5.29150262212918,0.7813139724735471,0.9279028588202761]
["TTCCCACTGTCCCTACCTACTTA",11.9058808997907,0.442471887682204,0.9279028588202761]
["TTAGAGAGAAAGAGAACTACT",3.96862696659689,0.7555093256130011,0.9279028588202761]
["ATTAATCCTCAAGCCTGTACAACC",6.61437827766148,0.7710368376932121,0.9279028588202761]
["GGACGCTCAGGAGGACTCTTCC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CGCCTGTCTCATTCTCTGCAGGT",10.5830052442584,0.478928007776159,0.9279028588202761]
["GCCCGCGTGGCGGGGCCCGGA",11.9058808997907,0.442471887682204,0.9279028588202761]
["CGTGGCGTCCCGGTAGCTCGC",5.29150262212918,0.7813139724735471,0.9279028588202761]
["TCCCGGCGAAGAGAAGAGACACA",6.61437827766148,0.7710368376932121,0.9279028588202761]
["TGACTGTCCTATGTCTTTCCTTC",6.61437827766148,0.7710368376932121,0.9279028588202761]
["CTCTGAAGCAACAGGATCTGAGG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["AGTAAGCCGTTTTAAAAACTGTT",97.8927985093898,0.652350029859396,0.9279028588202761]
["CCGCCGCGGCGGCCGTCGGGTGGG",6.61437827766148,0.7710368376932121,0.9279028588202761]
["ACCCGGCGGCCGTCGCGCGCCT",10.5830052442584,0.478928007776159,0.9279028588202761]
["CCCCGCGGCGGCGGCGGCGCCA",3.96862696659689,0.7555093256130011,0.9279028588202761]
["AATTACAGATTGTCTCAGAGAA",5.29150262212918,0.7813139724735471,0.9279028588202761]
["CCCCCGCGGGGGCCCGGGGCCT",64.8209071210825,0.5926771077494151,0.9279028588202761]
["CCCGGCGGCGGGCCGGGGCGAG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["ATCCCTGAAAGTATAGTCTTAACG",7.93725393319377,0.680518810404045,0.9279028588202761]
["GCTCCGGCGCTGCGTCTCCAGGC",5.29150262212918,0.7813139724735471,0.9279028588202761]
["AAAAGTGTAGAGACTTTGGAACCA",3.96862696659689,0.7555093256130011,0.9279028588202761]
["ATTAGCTCCCTCTTCCCATGTTCT",5.29150262212918,0.7813139724735471,0.9279028588202761]
["TCTCGGACAAGCTGTAGGTCCT",6.61437827766148,0.7710368376932121,0.9279028588202761]
["GCCCCCGGCGCGCCGGGCCCGGG",7.93725393319377,0.680518810404045,0.9279028588202761]
["GCACGTTCGTGGGGAACCTGG",5.29150262212918,0.7813139724735471,0.9279028588202761]
["GCCCGGGCGGGCGCCGGCCGCT",3.96862696659689,0.7555093256130011,0.9279028588202761]
["GCCCCGGGGCCGCGGGGGCG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["ACACAGAGGACCGTACGTTTT",7.93725393319377,0.680518810404045,0.9279028588202761]
["AAGGATGTGGATCTCCAAATAA",3.96862696659689,0.7555093256130011,0.9279028588202761]
["GCGCGTGACTCCCTCCGCCGCGAG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["GCCCCGCGGGGGCCCCGGCG",6.61437827766148,0.7710368376932121,0.9279028588202761]
["ATGGCCGCCCCCGCTCGCACCGC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["GAGGGGTCTCTGCCTCTACCC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CCCCGGGGCTCGCGAGGCGGTTCT",3.96862696659689,0.7555093256130011,0.9279028588202761]
["ATCTGAGGGCTGGGCACGGTGGC",9.26012958872607,0.555666568833184,0.9279028588202761]
["CGACCTCGCCGTCCCGCCCGCC",9.26012958872607,0.555666568833184,0.9279028588202761]
["CGGCCTCGCGGACCCTGCGCCTG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["TAAGCACTGCCTTTGAACCTGAT",17.1973835219198,0.37909403932556,0.9279028588202761]
["GTGCACGTGAGGATGGCTCTGAGA",3.96862696659689,0.7555093256130011,0.9279028588202761]
["TCTGGCTCCTTTCTAATCACTAT",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CCCACTGCTTCACTTGACTAACC",5.29150262212918,0.7813139724735471,0.9279028588202761]
["GTGACAGAGCGAGACCGTGTCTC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CAAAAATAGGAAGTCCAAGGACTG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CTCGGCGGCGTCGCGGCGGGTCT",5.29150262212918,0.7813139724735471,0.9279028588202761]
["CCCCGGGGCCGGGGGCGGAG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CACCCAGGCTGGACTGCAATGGC",3.96862696659689,0.7555093256130011,0.9279028588202761]
["CCTCCTCCCCGCCGGGGCCCGTCGTC",1.3228756555323,0.797337328146125,0.9279028588202761]
["AAGAGCAAAGAACCTGAGTGCCT",14.5516322108552,0.39960739713986904,0.9279028588202761]
["CTGCCGGGGCCCGCGGGCCTGCTG",9.26012958872607,0.555666568833184,0.9279028588202761]
["AGACGCGACCTCAGATCAGACGT",6.61437827766148,0.7710368376932121,0.9279028588202761]
["GTCCGCGGCGGGGCGCGGGG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["AAAAGAGATGCGGTAGCAGCTG",5.29150262212918,0.7813139724735471,0.9279028588202761]
["GCGCGCGCGCGGGAGGGCGGGCA",22.488886144049,0.356535852838458,0.9279028588202761]
["GGAGCAGGCTCCGGGGGACAGGG",5.29150262212918,0.7813139724735471,0.9279028588202761]
["GCCCGGCGCCGGGGGCGGCG",3.96862696659689,0.7555093256130011,0.9279028588202761]
["AGCACCTTGCCTGCGGGCTTTC",5.29150262212918,0.7813139724735471,0.9279028588202761]
["GCGCCCCGGGCGGGTCGCGCCG",900.878321417493,0.7081637103629741,0.9279028588202761]

{"sheet":"Expressed only Sample_3","index":4,"n_rows":71,"n_cols":4,"rows_kept":71,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["miRNA","Sample_3 Expression","P Value","Adjusted P Value"]
["TCTTCCCCTTAGTTTCCTTTAAG",0.7559289460184541,1,1]
["TACAACTCAGGGGCCAGGCACCAT",12.0948631362953,0.516671740561768,0.9279028588202761]
["TGCGGGCCCTGGGAGTGGAGAC",1.51185789203691,0.8816727168802,0.962961690776956]
["CTCTGAGCCTCCTTGTCGCCTGC",2.26778683805536,0.809090855727261,0.9279028588202761]
["AAAAGGGGGCTGAGGTGGAGGAAG",5.29150262212918,0.831497366994793,0.9279028588202761]
["TATTGACCCAGCGATGGGGGCTTC",2.26778683805536,0.809090855727261,0.9279028588202761]
["AAGCAGCAAGTAAATAATTGTGA",2.26778683805536,0.809090855727261,0.9279028588202761]
["GTGTCCCGGCCCGGAGCCGCCA",3.02371578407382,0.8039917845226141,0.9279028588202761]
["TCACTGCGCACTGCATCCTGTAG",0.7559289460184541,1,1]
["TTCCTTTGAAAAGATTGTCTTTCA",2.26778683805536,0.809090855727261,0.9279028588202761]
["CCCGGCGGAGGGTCCGGCAGG",2.26778683805536,0.809090855727261,0.9279028588202761]
["TTTAGTGGCTCCCTCTGCCTGCAG",9.82707629823991,0.593582268059833,0.9279028588202761]
["AAGTAAGCCGTTTTAAAAACTGTT",109.609697172676,0.6807519308536321,0.9279028588202761]
["GCCCGGCGTCCGGCCGACCGCC",0.7559289460184541,1,1]
["CCCGCCGCACCTCCTCCTGCA",2.26778683805536,0.809090855727261,0.9279028588202761]
["CTCCATTCTGAGCTTCTTTCTG",3.02371578407382,0.8039917845226141,0.9279028588202761]
["CCCCGCCGCGCGCCGGGCCGG",2.26778683805536,0.809090855727261,0.9279028588202761]
["CCCCGCGGGGGCCCGGGGCCTC",21.1660104885167,0.429203355580119,0.9279028588202761]
["CAAAGTATTTAGCTGACTCGCCA",6.04743156814764,0.830262182296649,0.9279028588202761]
["GTGTAACCCGCTGTCCCCGCAGA",2.26778683805536,0.809090855727261,0.9279028588202761]
["GAAGTTGCCCGTGTTTTTTTCGCT",3.02371578407382,0.8039917845226141,0.9279028588202761]
["CACCGCGGTCTTTTCCTCCCACTC",15.1185789203691,0.46912041986311,0.9279028588202761]
["ATCCCTGAAAGTATAGTCTTAGGT",4.53557367611073,0.824419671885335,0.9279028588202761]
["CAGTTCAATGGTGTTCAGCAGAC",2.26778683805536,0.809090855727261,0.9279028588202761]
["GTCATTTTTGTGATCTGCAGCTAG",3.77964473009227,0.8146448869122661,0.9279028588202761]
["CGCGTCCCGGTCGCCGCGGTTCG",3.77964473009227,0.8146448869122661,0.9279028588202761]
["GTAGCTGTGGCAGCTGCACCACCT",2.26778683805536,0.809090855727261,0.9279028588202761]
["ATAAAAACAGGCTCTCGCTCTGT",3.02371578407382,0.8039917845226141,0.9279028588202761]
["TCCCCGCCGGCGGGCCGCCCCCCCCC",6.04743156814764,0.830262182296649,0.9279028588202761]
["GTCCATTTTACAGAGCGCTGATTG",4.53557367611073,0.824419671885335,0.9279028588202761]
["TTTGGTTTTGTTTGGGTTTGTT",7.55928946018454,0.7711540075411321,0.9279028588202761]
["CCCCCCCGGCCCCGTCCGCCCC",5.29150262212918,0.831497366994793,0.9279028588202761]
["AGAATCTGTTGGTAAAGCCTCTC",4.53557367611073,0.824419671885335,0.9279028588202761]
["TTTGCACAAAGAGTCTCATGTCT",0.7559289460184541,1,1]
["CTCAGGATTTAAAGGGGCACTC",2.26778683805536,0.809090855727261,0.9279028588202761]
["ATCTTGTTAAAAAGCAGATTCT",5.29150262212918,0.831497366994793,0.9279028588202761]
["TACAGGATGCAGTGCTCAGTGATC",3.02371578407382,0.8039917845226141,0.9279028588202761]
["TGTCCTCCCTCTGCTCGCAGCTC",2.26778683805536,0.809090855727261,0.9279028588202761]
["GTGCCTCCAGGCGCAGGGCA",2.26778683805536,0.809090855727261,0.9279028588202761]
["ATTCCCACTGTCCCTACCTACTT",2.26778683805536,0.809090855727261,0.9279028588202761]
["TCTGGCTCCTTTCTAATCACTA",3.77964473009227,0.8146448869122661,0.9279028588202761]
["CAAAAATTGTAATTACTTTGGCAC",4.53557367611073,0.824419671885335,0.9279028588202761]
["CTCAGCCTGTGGACATGCCCACC",3.77964473009227,0.8146448869122661,0.9279028588202761]
["GACATGATGAGCTTTGTGCAAAA",3.02371578407382,0.8039917845226141,0.9279028588202761]
["ATTCAGCTACGATCACCAGGGCAT",2.26778683805536,0.809090855727261,0.9279028588202761]
["GCCGCTCTGGGCCCGACCCCGGC",2.26778683805536,0.809090855727261,0.9279028588202761]
["CATGTTCATGGACTGAAAGACTT",2.26778683805536,0.809090855727261,0.9279028588202761]
["ACCGGGTGCTGTAGGCTTTTTCTT",3.77964473009227,0.8146448869122661,0.9279028588202761]
["GGCGGCGGCGGGGGGAGAGGAA",2.26778683805536,0.809090855727261,0.9279028588202761]
["AATGCATGCTGGGCTTGTAACCT",2.26778683805536,0.809090855727261,0.9279028588202761]
["GCGGCGACGACCCATTCGAACGTC",0.7559289460184541,1,1]
["GAGAGATCAGAGGCGCAGAGTG",3.77964473009227,0.8146448869122661,0.9279028588202761]
["CTCTCCTAACCTCGCTCTCGCGG",3.02371578407382,0.8039917845226141,0.9279028588202761]
["CCCCGCCGCGCGCCGGGACCGGGG",7.55928946018454,0.7711540075411321,0.9279028588202761]
["GGAGCAGGCTCCGGGGGACAGGGA",7.55928946018454,0.7711540075411321,0.9279028588202761]
["TAAGCACTGCCTTTGAACCTGA",5.29150262212918,0.831497366994793,0.9279028588202761]
["GTTCTCCGTGGCCCTCCAGCGCCT",2.26778683805536,0.809090855727261,0.9279028588202761]
["CTTTCGATGGTAGTCGCCGTGCCT",9.82707629823991,0.593582268059833,0.9279028588202761]
["CTGGCTGGCTGCTCCGGGCACTGG",9.07114735222145,0.6434487633382331,0.9279028588202761]
["CACCTTAGAAGGTCTCACTGGT",2.26778683805536,0.809090855727261,0.9279028588202761]
["CTCCCCGACACCATGGCCCTGGC",4.53557367611073,0.824419671885335,0.9279028588202761]
["TAGGTCACTGGGGTCAGAGCCAGC",3.02371578407382,0.8039917845226141,0.9279028588202761]
["ACGGGTATTCTTGGGTGGATAATA",6.04743156814764,0.830262182296649,0.9279028588202761]
["TCCAGCGAGGGGCGCCCGGGG",2.26778683805536,0.809090855727261,0.9279028588202761]
["TAGATTGAAGCCAGTTGATTAG",2.26778683805536,0.809090855727261,0.9279028588202761]
["TACCGGGTGCTGTAGGCTTACTTT",3.02371578407382,0.8039917845226141,0.9279028588202761]
["ATGAGAGCGCTCGGTTTTTTGTGC",24.1897262725905,0.420815554551396,0.9279028588202761]
["TCTGTACCCTCACCTCACCCAGG",4.53557367611073,0.824419671885335,0.9279028588202761]
["TTGATGATCGTTCTTCTCTCCGT",8.315218406203,0.7069105701684061,0.9279028588202761]
["TCGCCGCTTTCTGGGCTCGCTCAC",5.29150262212918,0.831497366994793,0.9279028588202761]