File Name : fig.s1.tif

Caption : fig.s1 construction and analysis of metabolomic models for chip effluents from healthy and depressed groups.
a, compared to the healthy group,the pca analysis results of upper effluents from the dogc.
b, compared to the healthy group,the opls-da score plots of upper effluents from the dogc.
c, compared to the healthy group,the opls-da model permutation test plots for upper effluents from the dogc.
d, compared to the healthy group,the pca analysis results of lower effluents from the dogc.
e, compared to the healthy group,the opls-da score plots of lower effluents from the dogc.
f, compared to the healthy group,the opls-da model permutation test plots for lower effluents from the dogc.

File Name : fig.s2.tif

Caption : fig.s2 metabolism characteristics of lower effluent in dogc and its related kegg enrichment pathways.
a, volcano plots depicting differentially identified metabolites in dogc. red dots, upregulated metabolites(p < 0.05). blue dots, downregulated metabolites(p < 0.05). grey dots, nondifferentially expressed metabolites(p > 0.05).
b, compared to the healthy group, the top 10 differential metabolites in dogc. red: up-regulation, green:down-regulation.
c, compared to the healthy group, the upregulated differential metabolites in dogc are enriched in kegg.
d, compared to the healthy group, the downregulated differential metabolites in dogc are enriched in kegg.

File Name : fig.s3.tif

Caption : fig.s3 pathway classification of differentially identified metabolites in intestinal chip effluents.
a, compared to the healthy group, differential metabolite pathway classification chart in upper effluent of dogc.
b, compared to the healthy group, differential metabolite pathway classification chart in lower effluent of dogc.