File Name : fig. s1.tiff

Caption : fig. s1. scheme of lanio3 nanospheres production and modification with mab

File Name : fig. s2.tiff

Caption :  stages of synthesis of lnns. (a) external appearance of lnns formation upon addition of naoh; (b) lnns after precipitation, washing and concentration; (c) lnns after overnight drying at +37 °c; (d) lnns after calcination at +650 °c for 2 h

File Name : fig. s3.tiff

Caption : (a) size distribution of lanio3 ns by intensity. (b) an overview spectra of the lanio3 ns sample. (c) xps signal of lanio3 ns sample. (d) deconvolution analysis of la3d and ni2p3/2

File Name : fig. s4.tiff

Caption : (a) signal collection area for the lanio3 ns sample. (b) elemental composition of the lanio3 ns sample. (c) energy dispersive x-ray spectrum for the lanio3 ns sample.

File Name : fig. s5.tiff

Caption : (a) aggregation process during fuctionalization stages of the lnns; (b) stabilization of the lnns at the final stage of the diagnostic reagent produce.

File Name : fig. s6.tiff

Caption : (a) signal collection area for the lanio3@bsa/c6cc ns sample. (b) elemental composition of the lanio3@bsa/c6cc sample. (c) energy dispersive x-ray spectrum for the lanio3@bsa/c6cc ns sample.

File Name : fig. s7.tiff

Caption : (a,b) kinetic study of lanio3 ns using method based on the michaelis−menten equation. plots of initial velocities (v0) versus concentrations of (a) and its first fittings. plots of apparent maximum velocities (vmax,app) obtained from (a) versus concentrations of (b) h2o2 and (d) its  second fittings to obtain the intrinsic maximum velocities (vmax) and michaelis constants (km). (c) the determination of lanio3 ns specific activities, n = 3, mean ± sd. ( d) specific activity of nanozymes before and after the functionalization. 

File Name : fig. s8.tiff

Caption : evaluation of optimal conditions for nlisa based on lanio3@bsa/c6cc. (a) study of interference with mammalian blood sera. (b) optimization of the composition of the blocking solution (1.pbst; 2.pbst + 1% bsa; 3.pbst + 0.5% casein; 4.pbst + 1% casein; 5.pbst + 2% casein; 6.pbst + 1% bsa + 0.5% casein; 7.pbst + 1% bsa + 1% casein; 8.pbst + 1% bsa + 2% casein). (c) optimization of diagnostic reagent dilution (d) optimization of capture monoclonal antibody concentration; error bars indicate the standard deviation, n = 3