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Caption : supplementary fig. 1 macroscopic image (a) and anatomical diagram (b) of the gastric tissue. 

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Caption : supplementary fig. 2 analysis of diversity of gut microbiota. (a) kruskal-wallis h test for the ace index; (b) kruskal-wallis h test for the chao index; (c) kruskal-wallis h test for the shannon index; (d) pca analysis at the otu level. 

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Caption : supplementary fig. 3 (a) rda analysis of gut microbiota at the genus level; (b) correlation analysis between inflammatory factors and gut microbiota.

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Caption : supplementary fig. 4 3d-pca diagram of metabolites in the prevention group in positive (a) and negative (b) modes and pls-da replacement test in positive (c) and negative (d) modes. 

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Caption : supplementary fig. 5 cluster heatmap analysis of common differential metabolites of pm vs nc and psh vs pm metabolic set. 

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Caption : supplementary fig. 6 key metabolites. (a) the relative content of cdp-dg (txb2/20:4(8z,11z,14z,17z)); (b) the relative content of anhydrocinnzeylanol; (c) the relative content of versalide; (d) tthe relative content of difloxacin; (e) the relative content of 3’-o-methyl-(-)-epicatechin-7-o-sulphate; (f) the relative content of mpomeovt; (g) the relative content of dg (14:1(9z)/16:0/0:0); (h) the relative content of dichloroacetate; (i) the relative content of pe (22:0/24:0); (j) the relative content of 7-hydroxyabieta-8,11,13-rien-18-oic acid; (k) the relative content of primaquine; (l) the relative content of 5-hydroxy-14,16-hentriacontanedione; (m) the relative content of 2-hexaprenyl-6-methoxyphenol; (n) the relative content of (e)-casimiroedine; (o) the relative content of cortolone-3-glucuronide. p<0.05 indicates significant differences between groups.