File Name : supplemental figure 1 tiff.tiff

Caption : supplemental figure 1. concentration of model drug molecule doxorubicin within 0.6% agarose gel tumor phantom slices after perfusion with doxorubicin on three independent chips compared to culture on transwell membranes for up to 24 h. all data are mean ± standard deviation, with n =11-15 measurements per condition. condition differences at each time point were tested via two-way repeated-measures anova with fdr correction and were not significant, represented as “nd”.

File Name : supplemental figure 2 .pdf

Caption : supplemental figure 2. schematic diagram showing future possible higher-throughput drug screening. in this scenario, tissues are removed from excised tumors during surgery, sliced and placed on ice (~30 mins), followed by placing 5 slices into the dpc and sealing and perfusing (~15 mins). altogether, it would take ~2 h to load 8 dpcs if performed sequentially, or ~15 min in parallel with multiple people or automated sealing. created with biorender.com.