File Name : figure s1.tif Caption : figure s1. the tem image of cpw (scale bar: 100 nm). File Name : figure s2.tif Caption : figure s2. short-term stability of cp dispersed in different solution, including ph 7.4 pbs solution (a) and 10% fbs (b) at different time points within 72 h. File Name : figure s3.tif Caption : figure s3. the eds spectra of cp, as well as the wt % and at % of various elements. File Name : figure s4.tif Caption : figure s4. the powder xrd pattern of cp. File Name : figure s5.tif Caption : figure s5. evaluation on ph/gsh dual response of cp. (a)the photographs of cp dispersed in h2o, pbs (ph 7.4) and gsh (10 mm, ph 5.5) solution for 48 h, respectively. (b) size distribution change of cp after dispersed in different solution. (c) copper release profiles from cp under different conditions. File Name : figure s6.tif Caption : figure s6. evaluation on pod-like activity of cp. (a)the uv-vis absorption spectra of tmb catalytic oxidation under different conditions. (b) fluorescent spectra of ta after reaction with h2o2 at different concentrations of cp. File Name : figure s7.tif Caption : figure s7. cp-induced variation of gsh/gssg ratio. (a) the gsh/gssg ratio was used to evaluate the gpx-like activity of cp. (b) the gsh/gssg ratio in gsh depletion experiment under different concentrations of cp conditions. one-way analysis of variance (anova): ****p<0.0001. File Name : figure s8.tif Caption : figure s8. evaluation on cat-like activity of cp. (a) the photographs of cp dispersed in h2o and 30% h2o2 solution. (b) oxygen production of cp at different concentration. File Name : figure s9.tif Caption : figure s9. the influence of ha modification on catalytical activity of cp. (a)fluorescent spectra of ta after reaction with h2o2 in the presence of cpw or cp. (b) the quantified results from fluorescent comparison experiment. (c)the uv-vis absorption spectra of gpx-like capacity of cp in the presence of cpw or cp. (d) the gsh/gssg ratio from comparison experiment. (e) oxygen production of cp in the presence of cpw or cp. (mean±s.d., n=3). File Name : figure s10.tif Caption : figure s10. cell viability of different types of cells treated with cp at different concentrations. (a) lo2 cells, (b) t98g cells, (c) h1975 cells, (d) mda-mb-231 cells. (mean±s.d., n=3). File Name : figure s11.tif Caption : figure s11. relative fluorescent intensity analysis of hif-1α based on the data from figure 3f, using image-j software. student’s t test: ****p<0.0001. File Name : figure s12.tif Caption : figure s12. semiquantitative analysis of fdx1 expression based on the data from figure 4e. one-way analysis of variance (anova): **p<0.01, ***p<0.001. File Name : figure s13.tif Caption : figure s13. cell viability of a549 cells after different concentrations of elesclomol coupled with cu2+ treatments. (mean±s.d., n=3). File Name : figure s14.tif Caption : figure s14. in vivo antitumor activity of cp. (a) body weight curves of tumor-bearing mice after various treatments (mean±s.d., n=5). (b) the representative images of tumor-bearing nude mice in control and cp group after a period of 16 days treatments. File Name : figure s15.tif Caption : figure s15. quantified results of the proportion of positive signals stained by ki67 and dlat from control and cp group based on the data from figure 5f and 5g. (a) ki67 positive cells rate. (b) mean fluorescence intensity of dlat expression. student’s t test: ***p<0.001, ****p<0.0001. File Name : figure s16.tif Caption : figure s16. biocompatibility of cp. (a) h&e staining of the major organs (heart, liver, spleen, kidney and lung) of mice in cp group and healthy mice group. (b) hematological parameters analysis of healthy mice and tumor-bearing mice treated with cp. (c) blood biochemistry test after treatment with cp (mean±s.d., n=3).