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{"sheet":"Sheet 1 - Table 1 - Table 1","index":0,"n_rows":1517,"n_cols":9,"rows_kept":1517,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["//Original RT SN 04/23/8",{"$nulls":5},"REFERENCES","REFERENCES"]
[null,null,null,"k_on (gdw A.U^{-1} s^{-1})","k_off (s^{-1})","k_cat (s^{-1})"]
["//RA binding RAR"]
["RA+RAR","↔","RA_RAR","4.502e-01 ± 9.484e-16","7.595e+00 ± 1.250e-14"," -- ","http://www.cell.com/abstract/0092-8674(91)90020-Y","http://www.cell.com/abstract/0092-8674(91)90301-E"]
["RA+RXR","↔","RA_RXR","7.510e-01 ± 2.232e-16","9.155e+00 ± 1.071e-14"," -- ","http://www.cell.com/abstract/0092-8674(91)90020-Y","http://www.cell.com/abstract/0092-8674(91)90301-E"]
[]
["//"]
["//receptor tyrosine kinases activating MAPK Primary Pathway"]
["//"]
["//"]
["//Receptor Activation:"]
["//"]
["// EGF + EGFR  (mech: Scholber et al 2002)"]
["EGF+EGFR","↔","EGFR_EGF","9.645e-01 ± 1.897e-15","3.816e+00 ± 4.017e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["2*EGFR_EGF","↔","EGFR_EGF_2","1.608e-01 ± 1.953e-16","7.290e+00 ± 5.356e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["EGFR_EGF_2","↔","EGFR_EGF_2_p","8.452e-01 ± 4.463e-16","1.691e+00 ± 4.240e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["//"]
["// Her2 auto activation (exp: Samanta et al 1994)"]
["2*Her2","↔","Her2_2","1.030e-01 ± 1.674e-16","6.130e+00 ± 0.000e+00"," -- ","http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=43233"]
["Her2_2","↔","Her2_2_p","4.395e-01 ± 5.021e-16","4.726e-01 ± 1.674e-16"," -- ","http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=43233"]
["// Her2 phosphotase PAcP-igg (exp: Meng and Lin 1998)"]
["Her2_2_p+PAcPigg","↔","Her2_2_p_PAcPigg","2.866e-01 ± 6.137e-16","3.971e+00 ± 9.373e-15"," -- ","http://www.jbc.org/cgi/content/abstract/273/34/22096"]
["Her2_2_p_PAcPigg","→","Her2_2+PAcPigg","--","--","2.618e-01 ± 5.579e-17 ","http://www.jbc.org/cgi/content/abstract/273/34/22096"]
["// Her2 growth Factor "]
["Her2_2+PAcPprl","↔","Her2_2_PAcPprl","5.118e-01 ± 8.927e-16","6.440e+00 ± 5.356e-15"," -- ","http://www.jbc.org/cgi/content/abstract/273/34/22096"]
["Her2_2_PAcPprl","→","Her2_2_p+PAcPprl","--","--","7.457e-01 ± 1.116e-16 ","http://www.jbc.org/cgi/content/abstract/273/34/22096"]
["//"]
["// Receptor adaptor complexes:"]
["//"]
["//Receptor 1 (EGFR) adaptor Shc ind path (mech: Kholodenko et al 1999)"]
["EGFR_EGF_2_p+Grb2","↔","EGFR_EGF_2_p_Grb2","4.701e-01 ± 7.811e-16","1.469e+00 ± 1.562e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Grb2+Sos","↔","EGFR_EGF_2_p_Grb2_Sos","5.527e-01 ± 6.695e-16","5.678e+00 ± 8.927e-16"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Grb2_Sos","↔","EGFR_EGF_2_p+Grb2_Sos","3.957e-01 ± 1.116e-16","1.909e+00 ± 3.124e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["Grb2+Sos","↔","Grb2_Sos","8.667e-01 ± 1.116e-15","3.627e+00 ± 5.356e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["// Ras activation (Mech: Huang et al 1996 AND Brigthman and Fell 2000)"]
["EGFR_EGF_2_p_Grb2_Sos+Ras_GDP","↔","EGFR_EGF_2_p_Grb2_Sos_Ras_GDP","9.345e-01 ± 1.116e-15","1.333e+00 ± 1.562e-15"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["EGFR_EGF_2_p_Grb2_Sos_Ras_GDP","→","EGFR_EGF_2_p_Grb2_Sos+Ras_GTP","--","--","2.498e-01 ± 6.137e-16 ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["//"]
["// Receptor 2 (Her2) adaptor Sch ind path "]
["Her2_2_p+Grb2","↔","Her2_2_p_Grb2","1.543e-01 ± 2.232e-16","7.260e+00 ± 6.249e-15"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["Her2_2_p_Grb2+Sos","↔","Her2_2_p_Grb2_Sos","2.346e-01 ± 8.369e-17","5.613e-01 ± 1.339e-15"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["Her2_2_p_Grb2_Sos","↔","Her2_2_p+Grb2_Sos","8.385e-01 ± 1.116e-16","6.980e+00 ± 2.678e-15"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["// Ras activation (Mech: Huang et al 1996 AND Brigthman and Fell 2000) "]
["Her2_2_p_Grb2_Sos+Ras_GDP","↔","Her2_2_p_Grb2_Sos_Ras_GDP","5.478e-01 ± 3.347e-16","7.965e+00 ± 1.339e-14"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["Her2_2_p_Grb2_Sos_Ras_GDP","→","Her2_2_p_Grb2_Sos+Ras_GTP","--","--","2.228e-01 ± 2.790e-17 ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["//"]
["//Receptor 1 (EGFR) adaptor Sch dep path (mech: Kholodenko et al 1999) "]
["EGFR_EGF_2_p+Shc","↔","EGFR_EGF_2_p_Shc","7.315e-01 ± 0.000e+00","4.917e+00 ± 6.249e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Shc","→","EGFR_EGF_2_p_Shc_p","--","--","4.943e-02 ± 8.369e-17 ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Shc_p","↔","EGFR_EGF_2_p+Shc_p","7.730e-01 ± 5.579e-16","9.165e+00 ± 1.964e-14"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["Shc_p","→","Shc","--","--","2.739e-01 ± 2.232e-16 ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Shc_p+Grb2","↔","EGFR_EGF_2_p_Shc_p_Grb2","5.279e-01 ± 8.927e-16","9.775e-01 ± 1.562e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Shc_p_Grb2+Sos","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos","1.099e-01 ± 9.763e-17","4.985e+00 ± 2.678e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos","↔","EGFR_EGF_2_p+Shc_p_Grb2_Sos","8.976e-01 ± 2.232e-16","4.992e+00 ± 8.927e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["Shc_p+Grb2_Sos","↔","Shc_p_Grb2_Sos","2.814e-01 ± 3.347e-16","1.024e+00 ± 1.785e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169"]
["// Ras Activation (Mech: Huang et al 1996 AND Brigthman and Fell 2000)"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos+Ras_GDP","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos_Ras_GDP","8.566e-01 ± 2.009e-15","4.990e+00 ± 3.571e-15"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_Ras_GDP","→","EGFR_EGF_2_p_Shc_p_Grb2_Sos+Ras_GTP","--","--","4.407e-01 ± 3.905e-16 ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["//"]
["// Receptor 2 (Her2) adaptor Sch dep path "]
["Her2_2_p+Shc","↔","Her2_2_p_Shc","3.609e-01 ± 1.004e-15","9.330e+00 ± 5.356e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Shc","→","Her2_2_p_Shc_p","--","--","1.075e-01 ± 1.674e-16 ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Shc_p","↔","Her2_2_p+Shc_p","7.734e-01 ± 2.009e-15","8.075e-01 ± 1.897e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Shc_p+Grb2","↔","Her2_2_p_Shc_p_Grb2","4.353e-01 ± 2.232e-16","7.449e+00 ± 1.607e-14"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Shc_p_Grb2+Sos","↔","Her2_2_p_Shc_p_Grb2_Sos","9.838e-01 ± 1.227e-15","2.514e+00 ± 4.017e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Shc_p_Grb2_Sos","↔","Her2_2_p+Shc_p_Grb2_Sos","9.968e-01 ± 2.120e-15","1.494e+00 ± 4.017e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["// Ras Activation (Mech: Huang et al 1996 AND Brigthman and Fell 2000)"]
["Her2_2_p_Shc_p_Grb2_Sos+Ras_GDP","↔","Her2_2_p_Shc_p_Grb2_Sos_Ras_GDP","7.408e-01 ± 3.347e-16","3.696e+00 ± 6.249e-15"," -- ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["Her2_2_p_Shc_p_Grb2_Sos_Ras_GDP","→","Her2_2_p_Shc_p_Grb2_Sos+Ras_GTP","--","--","1.996e-01 ± 2.790e-17 ","http://www.pnas.org/content/93/19/10078.abstract "," http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378"]
["//"]
["// PLCg Pathway"]
["//"]
["//Receptor 1 (EGFR) activates PLCg (mech: Kholodenko 1999  exp: Nishibe 1990)"]
["EGFR_EGF_2_p+PLCg","↔","EGFR_EGF_2_p_PLCg","3.072e-01 ± 6.695e-16","5.541e+00 ± 3.571e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/1700866"]
["EGFR_EGF_2_p_PLCg","↔","EGFR_EGF_2_p_PLCg_p","3.676e-01 ± 1.004e-15","8.295e+00 ± 2.142e-14"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/1700866"]
["EGFR_EGF_2_p_PLCg_p","↔","EGFR_EGF_2_p+PLCg","4.277e-01 ± 1.116e-16","3.693e+00 ± 8.927e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/1700866"]
["PLCg_p","→","PLCg","--","--","5.782e-01 ± 1.339e-15 ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/1700866"]
["//"]
["//Receptor 2 (Her2) activates PLCg "]
["Her2_2_p+PLCg","↔","Her2_2_p_PLCg","4.207e-01 ± 6.695e-16","2.527e+00 ± 3.571e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_PLCg","↔","Her2_2_p_PLCg_p","6.651e-01 ± 7.811e-16","4.516e+00 ± 8.034e-15"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_PLCg_p","↔","Her2_2_p+PLCg","8.799e-01 ± 2.009e-15","5.356e+00 ± 1.428e-14"," -- ","http://www.jbc.org/cgi/content/abstract/274/42/30169","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["//"]
["//Receptor 1 internal (EGFRi) activates PLCg "]
["EGFRi_EGFi_2_p+PLCg","↔","EGFRi_EGFi_2_p_PLCg","8.586e-01 ± 7.811e-16","8.030e+00 ± 1.964e-14"," -- ","http://www.jbc.org/content/274/13/8958.full"]
["EGFRi_EGFi_2_p_PLCg","↔","EGFRi_EGFi_2_p_PLCg_p","1.456e-01 ± 1.953e-16","3.572e+00 ± 4.910e-15"," -- ","http://www.jbc.org/content/274/13/8958.full"]
["EGFRi_EGFi_2_p_PLCg_p","↔","EGFRi_EGFi_2_p+PLCg","3.812e-01 ± 9.484e-16","2.147e+00 ± 3.124e-15"," -- ","http://www.jbc.org/content/274/13/8958.full"]
["//"]
["// Activation of PKC via DAG (exp: lin 1993)"]
["DAG+PKC","↔","DAG_PKC","1.461e-01 ± 3.626e-16","1.893e-01 ± 2.790e-16"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8381049"]
["DAG_PKC","→","DAG+PKCact","--","--","2.741e-01 ± 5.021e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/8381049"]
["PKCact","→","PKC","--","--","2.402e-01 ± 3.905e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/8381049"]
["//"]
["// Activation of Ras via PKC ( exp: Wood 1992)"]
["PKCact+Ras_GDP","↔","PKCact_Ras_GDP","6.549e-01 ± 5.579e-16","9.260e+00 ± 3.571e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/1312393"]
["PKCact_Ras_GDP","↔","PKCact+Ras_GTP","5.716e-01 ± 7.811e-16","2.692e+00 ± 0.000e+00"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/1312393"]
["//"]
["// Activation of Raf via PKC (exp: Kolch 1993)"]
["PKCact+Raf","↔","PKCact_Raf","8.497e-02 ± 9.763e-17","1.367e+00 ± 1.562e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8321321"]
["PKCact_Raf","→","PKCact+Raf_p","--","--","7.796e-01 ± 1.227e-15 ","http://www.ncbi.nlm.nih.gov/pubmed/8321321"]
["//"]
["//primary MapK cascade:"]
["//"]
["// Ras deactivation (mech: Brightman et al 2000"," exp: Trahey 1987)"]
["Ras_GTP+GAP","↔","Ras_GTP_GAP","1.063e-02 ± 1.744e-17","2.168e-01 ± 1.674e-16"," -- ","http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378 ","http://www.sciencemag.org/cgi/content/abstract/238/4826/542"]
["Ras_GTP_GAP","→","Ras_GDP+GAP","--","--","1.507e-02 ± 2.267e-17 ","http://linkinghub.elsevier.com/retrieve/pii/S0014579300020378 ","http://www.sciencemag.org/cgi/content/abstract/238/4826/542"]
["// Raf activation (mech: Scholber et al 2002)"]
["Ras_GTP+Raf","↔","Ras_GTP_Raf","1.506e-02 ± 1.744e-17","1.107e-01 ± 1.395e-17"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["Ras_GTP_Raf","→","Ras_GTP+Raf_p","--","--","1.504e-02 ± 1.744e-17 ","http://dx.doi.org/10.1038/nbt0402-370"]
["// Raf deactivation via phosphatase (mech: Scholber et al 2002)"]
["Raf_p+Pase1","↔","Raf_p_Pase1","2.505e-02 ± 2.790e-17","2.777e-01 ± 4.463e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["Raf_p_Pase1","→","Raf+Pase1","--","--","2.088e-02 ± 2.092e-17 ","http://dx.doi.org/10.1038/nbt0402-370"]
["// MEK activation (mech: Scholber et al 2002)"]
["MEK+Raf_p","↔","MEK_Raf_p","1.655e-01 ± 3.068e-16","1.803e+00 ± 8.927e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["MEK_Raf_p","→","MEK_p+Raf_p","--","--","3.085e-01 ± 6.695e-16 ","http://dx.doi.org/10.1038/nbt0402-370"]
["MEK_p+Raf_p","↔","MEK_p_Raf_p","1.025e-01 ± 9.763e-17","2.960e-01 ± 5.579e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["MEK_p_Raf_p","→","MEK_pp+Raf_p","--","--","1.007e-01 ± 2.790e-17 ","http://dx.doi.org/10.1038/nbt0402-370"]
["// ERK activation (mech: Scholber et al 2002)"]
["ERK+MEK_pp","↔","ERK_MEK_pp","1.974e-01 ± 3.068e-16","2.196e-01 ± 1.116e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["ERK_MEK_pp","→","ERK_p+MEK_pp","--","--","5.399e-02 ± 1.325e-16 ","http://dx.doi.org/10.1038/nbt0402-370"]
["ERK_p+MEK_pp","↔","ERK_p_MEK_pp","2.531e-01 ± 3.347e-16","1.145e+00 ± 1.116e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["ERK_p_MEK_pp","→","ERK_pp+MEK_pp","--","--","1.057e-01 ± 0.000e+00 ","http://dx.doi.org/10.1038/nbt0402-370"]
["// MEK deactivation via phosphatase (mech: Scholber et al 2002)"]
["MEK_p+Pase2","↔","MEK_p_Pase2","1.530e-01 ± 1.674e-16","5.701e-01 ± 6.695e-16"," -- "]
["MEK_p_Pase2","→","MEK+Pase2","--","--","1.089e-01 ± 1.255e-16 ","http://dx.doi.org/10.1038/nbt0402-370"]
["MEK_pp+Pase2","↔","MEK_pp_Pase2","3.378e-02 ± 3.487e-17","3.055e-01 ± 6.695e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["MEK_pp_Pase2","→","MEK_p+Pase2","--","--","1.081e-01 ± 8.369e-17 ","http://dx.doi.org/10.1038/nbt0402-370"]
["// ERK deactivation via phosphatase (mech: Scholber et al 2002)"]
["ERK_p+Pase3","↔","ERK_p_Pase3","2.062e-01 ± 5.021e-16","1.714e+00 ± 2.232e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["ERK_p_Pase3","→","ERK+Pase3","--","--","1.550e-01 ± 2.232e-16 ","http://dx.doi.org/10.1038/nbt0402-370"]
["ERK_pp+Pase3","↔","ERK_pp_Pase3","1.404e-01 ± 1.953e-16","1.901e+00 ± 2.232e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370"]
["ERK_pp_Pase3","→","ERK_p+Pase3","--","--","1.072e-01 ± 2.092e-16 ","http://dx.doi.org/10.1038/nbt0402-370"]
["//"]
["//MapK negative feedback"]
["//"]
["// ERK  causes phosphorylation of Sos on EGFR complex (exp: Langlois 1995"," mech: Asthagiri 2001) "]
["EGFR_EGF_2_p_Grb2_Sos+ERK_pp","↔","EGFR_EGF_2_p_Grb2_Sos_ERK_pp","7.106e-01 ± 2.232e-16","7.386e+00 ± 2.678e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["EGFR_EGF_2_p_Grb2_Sos_ERK_pp","→","EGFR_EGF_2_p_Grb2_Sos_p+ERK_pp","--","--","4.589e-01 ± 2.790e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["// same as above"," but for Shc dep path"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos+ERK_pp","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos_ERK_pp","6.509e-01 ± 1.004e-15","4.767e+00 ± 4.463e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_ERK_pp","→","EGFR_EGF_2_p_Shc_p_Grb2_Sos_p+ERK_pp","--","--","1.400e-01 ± 0.000e+00 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["// dissacociation of Sos_p from Grb2 (exp: Langlois 1995)"]
["EGFR_EGF_2_p_Grb2_Sos_p","→","EGFR_EGF_2_p_Grb2+Sos_p","--","--","5.218e-01 ± 5.579e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/7592690"]
["//same as above but for Shc dep path"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_p","→","EGFR_EGF_2_p_Shc_p_Grb2+Sos_p","--","--","4.339e-01 ± 7.811e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/7592690"]
["// dissociation of Sos_p Grb2 complex from EGFR receptor ( exp: Bunday 1995)"]
["EGFR_EGF_2_p_Grb2_Sos_p","→","EGFR_EGF_2_p+Grb2_Sos_p","--","--","4.544e-01 ± 6.695e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/7478553"]
["//same as above but for Shc dep path"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_p","→","EGFR_EGF_2_p_Shc_p+Grb2_Sos_p","--","--","9.991e-01 ± 1.116e-15 ","http://www.ncbi.nlm.nih.gov/pubmed/7478553"]
["//"]
["// ERK (may actually be MEK here) causes phosphorylation of Sos on EGFRi complex (exp: Langlois 1995"," mech: Asthagiri 2001)"]
["// Evidance that internalized EGFR complexes still undergo SIMILAR signalling at Jiang 2002 "]
["EGFRi_EGFi_2_p_Grb2_Sos+ERK_pp","↔","EGFRi_EGFi_2_p_Grb2_Sos_ERK_pp","2.362e-01 ± 1.953e-16","3.670e+00 ± 5.802e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698 ","http://www.molbiolcell.org/cgi/content/abstract/13/5/1522"]
["EGFRi_EGFi_2_p_Grb2_Sos_ERK_pp","→","EGFRi_EGFi_2_p_Grb2_Sos_p+ERK_pp","--","--","5.742e-01 ± 1.227e-15 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698 ","http://www.molbiolcell.org/cgi/content/abstract/13/5/1522"]
["// same as above"," but for Shc dep path"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos+ERK_pp","↔","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_ERK_pp","2.574e-01 ± 3.347e-16","6.189e+00 ± 5.356e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698 ","http://www.molbiolcell.org/cgi/content/abstract/13/5/1522"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_ERK_pp","→","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_p+ERK_pp","--","--","4.778e-01 ± 5.579e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698 ","http://www.molbiolcell.org/cgi/content/abstract/13/5/1522"]
["// dissacociation of Sos_p from Grb2 (exp: Langlois 1995)"]
["EGFRi_EGFi_2_p_Grb2_Sos_p","→","EGFRi_EGFi_2_p_Grb2+Sos_p","--","--","9.444e-02 ± 1.534e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/7592690"]
["//same as above but for Shc dep path"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_p","→","EGFRi_EGFi_2_p_Shc_p_Grb2+Sos_p","--","--","3.608e-01 ± 3.347e-16 "]
["// dissociation of Sos_p Grb2 complex from EGFR receptor ( exp: Bunday 1995)"]
["EGFRi_EGFi_2_p_Grb2_Sos_p","→","EGFRi_EGFi_2_p+Grb2_Sos_p","--","--","3.631e-02 ± 9.763e-17 ","http://www.ncbi.nlm.nih.gov/pubmed/7478553"]
["//same as above but for Shc dep path"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_p","→","EGFRi_EGFi_2_p_Shc_p+Grb2_Sos_p","--","--","2.087e-01 ± 2.790e-17 ","http://www.ncbi.nlm.nih.gov/pubmed/7478553"]
["//"]
["// ERK causes phosphorylation of Sos on Her2 complex "]
["Her2_2_p_Grb2_Sos+ERK_pp","↔","Her2_2_p_Grb2_Sos_ERK_pp","3.956e-01 ± 1.674e-16","7.152e+00 ± 1.607e-14"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Grb2_Sos_ERK_pp","→","Her2_2_p_Grb2_Sos_p+ERK_pp","--","--","4.625e-01 ± 6.695e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["// same as above"," but for Shc dep path"]
["Her2_2_p_Shc_p_Grb2_Sos+ERK_pp","↔","Her2_2_p_Shc_p_Grb2_Sos_ERK_pp","4.998e-01 ± 6.137e-16","8.555e+00 ± 1.785e-14"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Her2_2_p_Shc_p_Grb2_Sos_ERK_pp","→","Her2_2_p_Shc_p_Grb2_Sos_p+ERK_pp","--","--","3.643e-01 ± 6.137e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["// dissacociation of Sos_p from Grb2 (exp: Langlois 1995)"]
["Her2_2_p_Grb2_Sos_p","→","Her2_2_p_Grb2+Sos_p","--","--","5.737e-01 ± 0.000e+00 ","http://www.ncbi.nlm.nih.gov/pubmed/7592690"]
["//same as above but for Shc dep path"]
["Her2_2_p_Shc_p_Grb2_Sos_p","→","Her2_2_p_Shc_p_Grb2+Sos_p","--","--","3.180e-01 ± 3.905e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["// dissociation of Sos_p Grb2 complex from EGFR receptor ( exp: Bunday 1995)"]
["Her2_2_p_Grb2_Sos_p","→","Her2_2_p+Grb2_Sos_p","--","--","8.374e-01 ± 7.811e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/7478553"]
["//same as above but for Shc dep path"]
["Her2_2_p_Shc_p_Grb2_Sos_p","→","Her2_2_p_Shc_p+Grb2_Sos_p","--","--","7.458e-01 ± 5.579e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["// deactivation of Sos"]
["Sos_p+SosPase","↔","Sos_p_SosPase","5.358e-01 ± 8.927e-16","7.444e+00 ± 9.819e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Sos_p_SosPase","→","Sos+SosPase","--","--","6.071e-01 ± 1.004e-15 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Grb2_Sos_p+SosPase","↔","Grb2_Sos_p_SosPase","8.361e-01 ± 8.927e-16","5.245e+00 ± 5.356e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["Grb2_Sos_p_SosPase","→","Grb2_Sos+SosPase","--","--","1.996e-01 ± 2.232e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698","http://www.ncbi.nlm.nih.gov/pubmed/7478576"]
["//"]
["// ERK retrophosphorilation of MEK (Thr -292 and/or -386) (exp: Burnet 1994)"]
["ERK_pp+MEK","↔","ERK_pp_MEK","8.220e-01 ± 1.116e-16","7.297e+00 ± 9.819e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8013650"]
["ERK_pp_MEK","→","ERK_pp+MEK_rp","--","--","7.269e-01 ± 6.695e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/8013650"]
["// MEK de-retrophosphorylation"]
["MEK_rp+Pase2","↔","MEK_rp_Pase2","6.375e-01 ± 5.579e-16","8.202e-01 ± 8.927e-16"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8013650"]
["MEK_rp_Pase2","→","MEK+Pase2","--","--","7.143e-01 ± 1.562e-15 ","http://www.ncbi.nlm.nih.gov/pubmed/8013650"]
["//"]
["// ERK retrophosphorilation of Raf (exp: Wartmann 1997"," mech: Asthagiri 2001)"]
["ERK_pp+Raf_p","↔","ERK_pp_Raf_p","8.173e-01 ± 5.579e-16","5.726e+00 ± 4.463e-15"," -- ","http://www.jbc.org/cgi/content/abstract/272/7/3915 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["ERK_pp_Raf_p","→","ERK_pp+Raf_p_rp","--","--","9.214e-01 ± 8.927e-16 ","http://www.jbc.org/cgi/content/abstract/272/7/3915 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["Raf_p_rp+Pase1","↔","Raf_p_rp_Pase1","2.040e-01 ± 1.395e-16","6.770e+00 ± 1.160e-14"," -- ","http://www.jbc.org/cgi/content/abstract/272/7/3915 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["Raf_p_rp_Pase1","→","Raf_p+Pase1","--","--","6.174e-01 ± 1.451e-15 ","http://www.jbc.org/cgi/content/abstract/272/7/3915 ","http://www.ncbi.nlm.nih.gov/pubmed/11312698"]
["//"]
["// MAPK positive feedback"]
["//"]
["// activation of cPLA2 (exp: Lin 1993)"]
["// using ERK here but may be another kinase in the cascade"," also "]
["// cPLA2 requires Ca2+"," which can be enduced via IP3 see PLCg pathway above"]
["ERK_pp+cPLA2","↔","ERK_pp_cPLA2","5.309e-01 ± 6.695e-16","4.672e+00 ± 1.160e-14"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8381049"]
["ERK_pp_cPLA2","→","ERK_pp+cPLA2_p","--","--","4.291e-01 ± 4.463e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/8381049"]
["cPLA2_p","→","cPLA2","--","--","8.004e-01 ± 1.227e-15 ","http://www.ncbi.nlm.nih.gov/pubmed/8381049"]
["// cPLA2 activates PKC (exp: Shinomura 1991)"]
["// NOTE: it is actually the fatty acid produced by cPLA2 which is the activator"]
["cPLA2_p+PKC","↔","cPLA2_p_PKC","4.495e-01 ± 7.253e-16","9.509e+00 ± 1.428e-14"," -- ","http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=51829"]
["cPLA2_p_PKC","→","cPLA2_p+PKCact","--","--","6.991e-01 ± 1.004e-15 ","http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=51829"]
["//"]
["// Internalization"]
["//"]
["// Receptor 1 (EGFR) Prot ind internilization for Sch ind path"]
["// This includes both the internalization of EGFR complexs (mech: Scholber 2002 AND mech: Starbuck 1992) "]
["// and the internalized versions of addaptor formation (mech: Scholber 2002 AND exp: Jiang 2002)"]
["EGFR","↔","EGFRi","3.143e-01 ± 1.674e-16","4.403e+00 ± 9.819e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi+EGFi","↔","EGFRi_EGFi","1.414e-01 ± 3.905e-16","3.808e+00 ± 5.802e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["2*EGFRi_EGFi","↔","EGFRi_EGFi_2","4.981e-01 ± 1.674e-16","7.756e+00 ± 1.160e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p","→","EGFRi_EGFi_2_p","--","--","3.263e-01 ± 5.021e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2","↔","EGFRi_EGFi_2_p","8.348e-02 ± 5.579e-17","7.974e+00 ± 1.160e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p_Grb2","→","EGFRi_EGFi_2_p_Grb2","--","--","1.938e-01 ± 1.953e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p+Grb2","↔","EGFRi_EGFi_2_p_Grb2","3.244e-01 ± 1.674e-16","8.704e+00 ± 1.250e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p_Grb2_Sos","→","EGFRi_EGFi_2_p_Grb2_Sos","--","--","1.646e-01 ± 4.742e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p+Grb2_Sos","↔","EGFRi_EGFi_2_p_Grb2_Sos","8.655e-01 ± 1.339e-15","2.394e+00 ± 3.571e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Grb2+Sos","↔","EGFRi_EGFi_2_p_Grb2_Sos","8.576e-01 ± 2.120e-15","8.654e+00 ± 1.071e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Grb2_Sos+Ras_GDP","↔","EGFRi_EGFi_2_p_Grb2_Sos_Ras_GDP","8.051e-01 ± 3.347e-16","5.553e+00 ± 8.927e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Grb2_Sos_Ras_GDP","→","EGFRi_EGFi_2_p_Grb2_Sos+Ras_GTP","--","--","7.376e-01 ± 1.339e-15 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["//"]
["// Receptor 1 (EGFR) Prot ind internalization for Sch dep path"]
["// This includes both the internalization of EGFR complexs (mech: Scholber 2002 AND mech: Starbuck 1992)"]
["// and the internalized versions of addaptor formation (mech: Scholber 2002 AND exp Jaing 2002)"]
["EGFRi_EGFi_2_p+Shc","↔","EGFRi_EGFi_2_p_Shc","9.358e-01 ± 1.897e-15","3.012e+00 ± 4.463e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p_Shc","→","EGFRi_EGFi_2_p_Shc","--","--","4.424e-01 ± 3.905e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc","→","EGFRi_EGFi_2_p_Shc_p","--","--","3.156e-01 ± 4.463e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p_Shc_p","→","EGFRi_EGFi_2_p_Shc_p","--","--","6.008e-01 ± 1.116e-15 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc_p","↔","EGFRi_EGFi_2_p+Shc_p","1.015e-01 ± 9.763e-17","9.713e+00 ± 1.607e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc_p+Grb2","↔","EGFRi_EGFi_2_p_Shc_p_Grb2","7.006e-01 ± 3.347e-16","8.088e+00 ± 1.785e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p_Shc_p_Grb2","→","EGFRi_EGFi_2_p_Shc_p_Grb2","--","--","2.858e-01 ± 1.674e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc_p_Grb2+Sos","↔","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos","4.115e-02 ± 0.000e+00","8.847e+00 ± 1.250e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos","→","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos","--","--","6.622e-01 ± 5.579e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos","↔","EGFRi_EGFi_2_p+Shc_p_Grb2_Sos","9.878e-01 ± 2.232e-16","2.228e+00 ± 4.463e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos+Ras_GDP","↔","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_Ras_GDP","5.564e-02 ± 8.369e-17","9.327e+00 ± 2.142e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_Ras_GDP","→","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos+Ras_GTP","--","--","3.853e-01 ± 0.000e+00 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006","http://dx.doi.org/10.1091/mbc.01-11-0552"]
["//"]
["// Receptor 1 (EGFR) Prot dep internilization for Sch ind path (mech: Scholber 2002 and starbuck 1992)"]
["EGFR_EGF_2_p_Grb2+Prot","↔","EGFR_EGF_2_p_Grb2_Prot","3.868e-01 ± 7.253e-16","1.440e+00 ± 4.463e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Grb2_Prot","→","EGFRi_EGFi_2_p_Grb2+Proti","--","--","3.615e-02 ± 9.763e-17 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Grb2_Sos+Prot","↔","EGFR_EGF_2_p_Grb2_Sos_Prot","6.676e-01 ± 1.674e-15","9.438e+00 ± 1.785e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Grb2_Sos_Prot","→","EGFRi_EGFi_2_p_Grb2_Sos+Proti","--","--","7.817e-01 ± 2.009e-15 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Grb2_Sos_Ras_GDP+Prot","↔","EGFR_EGF_2_p_Grb2_Sos_Ras_GDP_Prot","8.148e-01 ± 8.927e-16","1.248e-01 ± 3.068e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Grb2_Sos_Ras_GDP_Prot","→","EGFRi_EGFi_2_p_Grb2_Sos_Ras_GDP+Proti","--","--","7.582e-01 ± 1.785e-15 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["//"]
["// Receptor 1 (EGFR) Prot dep internilization for Sch dep path (mech: Scholber 2002 and starbuck 1992)"]
["EGFR_EGF_2_p_Shc_p_Grb2+Prot","↔","EGFR_EGF_2_p_Shc_p_Grb2_Prot","6.302e-02 ± 1.534e-16","2.220e+00 ± 5.356e-15"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Shc_p_Grb2_Prot","→","EGFRi_EGFi_2_p_Shc_p_Grb2+Proti","--","--","9.533e-01 ± 1.897e-15 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos+Prot","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos_Prot","3.120e-01 ± 1.674e-16","2.421e+00 ± 4.463e-16"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_Prot","→","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos+Proti","--","--","5.398e-01 ± 7.811e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_Ras_GDP+Prot","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos_Ras_GDP_Prot","9.069e-01 ± 1.004e-15","4.962e+00 ± 1.071e-14"," -- ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_Ras_GDP_Prot","→","EGFRi_EGFi_2_p_Shc_p_Grb2_Sos_Ras_GDP+Proti","--","--","7.754e-01 ± 1.674e-15 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["//"]
["//Activation of Transcription factors via ERK_pp "]
["ERK_pp+ETS","↔","ERK_pp_ETS","7.186e-02 ± 0.000e+00","4.135e-01 ± 5.579e-16"," -- ","http://www.pnas.org/content/91/9/3844.abstract"]
["ERK_pp_ETS","→","ERK_pp+ETS_p","--","--","4.836e-01 ± 3.905e-16 ","http://www.pnas.org/content/91/9/3844.abstract"]
["ETS_p+Pase5","↔","ETS_p_Pase5","9.224e-01 ± 1.116e-15","3.487e+00 ± 5.356e-15"," -- "]
["ETS_p_Pase5","→","ETS+Pase5","--","--","1.138e-01 ± 2.790e-16 "]
["ERK_pp+AP1","↔","ERK_pp_AP1","4.985e-01 ± 6.695e-16","4.555e+00 ± 7.141e-15"," -- ","http://www.pnas.org/content/91/9/3844.abstract"]
["ERK_pp_AP1","→","ERK_pp+AP1_p","--","--","7.588e-01 ± 1.562e-15 ","http://www.pnas.org/content/91/9/3844.abstract"]
["AP1_p+Pase6","↔","AP1_p_Pase6","3.836e-01 ± 3.905e-16","9.394e+00 ± 1.428e-14"," -- "]
["AP1_p_Pase6","→","AP1+Pase6","--","--","8.988e-01 ± 0.000e+00 "]
["//"]
["// Degradation"]
["//"]
[]
["EGFi","→","[]","--","--","1.766e-01 ± 1.674e-16 ","http://dx.doi.org/10.1038/nbt0402-370 ","http://www.ncbi.nlm.nih.gov/pubmed/1368006"]
["//"]
["// Inhibition "]
["//"]
["//inHer2","inHer2+Her2","Her2_inHer2","-inf","inf;"]
["//inMEK","inMEK+MEK","MEK_inMEK","-inf","inf;"]
[]
["// Jianrong Wang and Andrew Yen"," \"A Novel Retinoic Acid-Induced BLR1 Expression"," p. 2441"]
["RA_RAR+g_BLR1","↔","RA_RAR_g_BLR1","2.165e+02 ± 3.142e-13","2.366e+02 ± 3.713e-13"," -- ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1+RA_RXR","↔","RA_RAR_g_BLR1_RA_RXR","1.128e+03 ± 2.057e-12","5.955e+02 ± 1.371e-12"," -- ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR+Oct1","↔","RA_RAR_g_BLR1_RA_RXR_Oct1","5.326e+02 ± 5.713e-13","2.050e+02 ± 2.285e-13"," -- ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR_Oct1+NFATc3_p","↔","RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p","1.076e+03 ± 1.828e-12","9.958e+02 ± 1.143e-12"," -- ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p+CREB","↔","RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_CREB","2.083e+03 ± 5.027e-12","2.053e+02 ± 2.857e-14"," -- ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_CREB","→","RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_CREB_activated","--","--","3.716e+03 ± 2.285e-12 ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_CREB_activated","→","RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_activated+CREB","--","--","6.762e+03 ± 1.828e-12 ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_activated+RNAp","→","RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_activated_RNAp","--","--","8.968e+03 ± 1.645e-11 ","http://dx.doi.org/10.1074/jbc.M708471200"]
["RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p_activated_RNAp","→","RA_RAR_g_BLR1_RA_RXR_Oct1_NFATc3_p+RNAp+Cap_mRNA_n_BLR1","--","--","2.221e+03 ± 4.570e-12 ","http://dx.doi.org/10.1074/jbc.M708471200"]
["// MAPK and Cell Cycle G1/S (rudimentary)"]
["ERK_pp+AP1","↔","ERK_pp_AP1","6.872e-01 ± 5.579e-16","6.208e-01 ± 7.811e-16"," -- "]
["ERK_pp_AP1","→","ERK_pp+AP1_p","--","--","5.872e-01 ± 1.227e-15 "]
["AP1_p+Pase6","↔","AP1_p_Pase6","9.588e-01 ± 7.811e-16","5.518e+00 ± 0.000e+00"," -- "]
["AP1_p_Pase6","→","AP1+Pase6","--","--","5.647e-01 ± 7.811e-16 "]
["// AP1_p is a transcription factor for CycD"," I (SN) am eliminating the translation machinery by directly making protein"]
["g_CycD+AP1_p","↔","g_CycD_AP1_p","1.353e-01 ± 2.232e-16","9.359e+00 ± 8.927e-15"," -- ","http://www.nature.com/onc/journal/v20/n19/full/1204383a.html","http://www.jbc.org/content/270/40/23589.abstract"]
["g_CycD_AP1_p+RNAp","↔","g_CycD_AP1_p_RNAp","5.981e-01 ± 1.227e-15","4.126e+00 ± 4.463e-15"," -- ","http://www.nature.com/onc/journal/v20/n19/full/1204383a.html","http://www.jbc.org/content/270/40/23589.abstract"]
["g_CycD_AP1_p_RNAp","→","g_CycD_AP1_p+RNAp+CycD","--","--","1.846e-01 ± 2.790e-17 ","http://www.nature.com/onc/journal/v20/n19/full/1204383a.html","http://www.jbc.org/content/270/40/23589.abstract"]
["// Cell Cycle machinery (G1/S) - CycD interacts with Cdk4/6"]
["CycD+Cdk4","↔","CycD_Cdk4","1.612e-01 ± 2.232e-16","6.180e+00 ± 0.000e+00"," -- ","http://mcb.asm.org/cgi/content/abstract/14/4/2713"]
["CycD+Cdk6","↔","CycD_Cdk6","5.009e-01 ± 1.116e-16","7.706e+00 ± 1.607e-14"," -- ","http://mcb.asm.org/cgi/content/abstract/14/3/2077"]
["// CycD-Cdk4/6 is inactivated by INK family p15",16,18,19]
["CycD_Cdk4+p15","↔","CycD_Cdk4_p15","8.324e-01 ± 1.227e-15","6.041e+00 ± 8.927e-16"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk4+p16","↔","CycD_Cdk4_p16","2.118e-01 ± 8.369e-17","1.393e+00 ± 1.116e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk4+p17","↔","CycD_Cdk4_p18","2.830e-01 ± 2.790e-16","8.118e+00 ± 1.785e-14"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk4+p18","↔","CycD_Cdk4_p19","8.487e-01 ± 3.347e-16","6.478e+00 ± 5.356e-15"," -- ","http://mcb.asm.org/cgi/content/abstract/15/5/2672"]
["CycD_Cdk6+p15","↔","CycD_Cdk6_p15","1.285e-02 ± 0.000e+00","1.652e+00 ± 3.347e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk6+p16","↔","CycD_Cdk6_p16","7.945e-01 ± 1.227e-15","3.614e+00 ± 4.910e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk6+p18","↔","CycD_Cdk6_p18","8.819e-01 ± 8.927e-16","3.533e-01 ± 7.811e-16"," -- ","http://mcb.asm.org/cgi/content/abstract/15/5/2672"]
["CycD_Cdk6+p19","↔","CycD_Cdk6_p19","7.579e-01 ± 1.562e-15","6.206e+00 ± 1.785e-15"," -- ","http://mcb.asm.org/cgi/content/abstract/15/5/2672"]
["// CycD-Cdk 4/6 is also inhibited by p21","p27 and p57"]
["CycD_Cdk4+p21","↔","CycD_Cdk4_p21","5.580e-01 ± 1.004e-15","6.670e+00 ± 2.678e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk4+p27","↔","CycD_Cdk4_p27","5.020e-01 ± 5.579e-16","7.373e+00 ± 8.034e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk4+p57","↔","CycD_Cdk4_p57","6.119e-01 ± 1.451e-15","3.018e+00 ± 4.463e-16"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk6+p21","↔","CycD_Cdk6_p21","2.625e-01 ± 3.347e-16","8.911e+00 ± 8.927e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk6+p27","↔","CycD_Cdk6_p27","2.300e-01 ± 4.463e-16","3.521e+00 ± 3.571e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycD_Cdk6+p57","↔","CycD_Cdk6_p57","6.606e-01 ± 5.579e-16","2.460e+00 ± 3.571e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["// CycD-Cdk4/6 can phosphorylate pRb-E2F to free E2F"]
["CycD_Cdk4+pRb_E2F","↔","CycD_Cdk4_pRb_E2F","3.744e-01 ± 4.463e-16","8.188e+00 ± 1.071e-14"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8449399"]
["CycD_Cdk4_pRb_E2F","→","CycD_Cdk4+pRb_p+E2F","--","--","2.878e-01 ± 4.463e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/8449399"]
["CycD_Cdk6+pRb_E2F","↔","CycD_Cdk6_pRb_E2F","2.838e-01 ± 3.905e-16","3.646e+00 ± 1.339e-15"," -- "]
["CycD_Cdk6_pRb_E2F","→","CycD_Cdk6+pRb_p+E2F","--","--","5.100e-01 ± 1.004e-15 "]
["// E2F is a transcription factor for CycE"]
["g_CycE+E2F","↔","g_CycE_E2F","2.994e-01 ± 5.579e-17","3.597e+00 ± 5.356e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8649818 ","http://www.pnas.org/content/92/26/12146.abstract"]
["g_CycE_E2F+RNAp","↔","g_CycE_E2F_RNAp","2.738e-01 ± 3.905e-16","5.221e+00 ± 8.034e-15"," -- ","http://www.ncbi.nlm.nih.gov/pubmed/8649818 ","http://www.pnas.org/content/92/26/12146.abstract"]
["g_CycE_E2F_RNAp","→","g_CycE_E2F+RNAp+CycE","--","--","2.910e-01 ± 4.463e-16 ","http://www.ncbi.nlm.nih.gov/pubmed/8649818 ","http://www.pnas.org/content/92/26/12146.abstract"]
["// CycE binds with Cdk2"]
["CycE+Cdk2","↔","CycE_Cdk2","5.250e-01 ± 1.116e-15","2.413e+00 ± 3.571e-15"," -- "]
["// CycE_Cdk2 has to be activated by aCDC25A"]
["CycE_Cdk2+aCDC25A","↔","CycE_Cdk2_aCDC25A","8.706e-01 ± 0.000e+00","4.543e+00 ± 8.034e-15"," -- ","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC394984/"]
["CycE_Cdk2_aCDC25A","→","aCycE_Cdk2+aCDC25A","--","--","7.343e-01 ± 0.000e+00 ","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC394984/"]
["// Activated CycE_Cdk2 in turn"," activates CDC25A"]
["CDC25A+aCycE_Cdk2","↔","CDC25A_aCycE_Cdk2","7.847e-01 ± 7.811e-16","1.250e+00 ± 3.347e-15"," -- ","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395357/"]
["CDC25A_aCycE_Cdk2","→","aCDC25A+aCycE_Cdk2","--","--","5.042e-01 ± 1.116e-16 ","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395357/"]
["// Both active and inactive form of CycE_Cdk2 can be inactivated by p21","p27 and p57"]
["CycE_Cdk2+p21","↔","CycE_Cdk2_p21","6.564e-01 ± 1.227e-15","4.636e+00 ± 5.356e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycE_Cdk2+p27","↔","CycE_Cdk2_p27","3.894e-01 ± 5.579e-16","1.580e+00 ± 1.339e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["CycE_Cdk2+p57","↔","CycE_Cdk2_p57","4.411e-01 ± 1.674e-16","7.932e+00 ± 1.250e-14"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["aCycE_Cdk2+p21","↔","aCycE_Cdk2_p21","8.423e-04 ± 0.000e+00","6.178e-02 ± 1.534e-16"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["aCycE_Cdk2+p27","↔","aCycE_Cdk2_p27","9.618e-01 ± 1.339e-15","1.377e+00 ± 0.000e+00"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["aCycE_Cdk2+p57","↔","aCycE_Cdk2_p57","8.680e-01 ± 7.811e-16","4.607e+00 ± 6.249e-15"," -- ","http://www.jbc.org/content/270/31/18195.full"]
["// Active CycE_Cdk2 can phosphorylate pRB_E2F to free more E2F"]
["aCycE_Cdk2+pRb_E2F","↔","aCycE_Cdk2_pRb_E2F","2.457e-01 ± 2.232e-16","4.205e+00 ± 2.678e-15"," -- ","Cell, Vol. 81, 323-330","http://mcb.asm.org/cgi/content/abstract/15/5/2612"]
["aCycE_Cdk2_pRb_E2F","→","aCycE_Cdk2+pRb_p+E2F","--","--","4.638e-01 ± 5.021e-16 ","Cell, Vol. 81, 323-330","http://mcb.asm.org/cgi/content/abstract/15/5/2612"]
["// E2F is also a transcription factor for itself"]
["g_E2F+E2F","↔","g_E2F_E2F","9.344e-02 ± 1.674e-16","3.643e-01 ± 4.463e-16"," -- ","http://dx.doi.org/10.1016/S0304-419X(02)00051-3","http://dx.doi.org/10.1016/0092-8674(91)90557-F"]
["g_E2F_E2F+RNAp","↔","g_E2F_E2F_RNAp","8.826e-01 ± 1.339e-15","1.002e+00 ± 1.116e-15"," -- ","http://dx.doi.org/10.1016/S0304-419X(02)00051-3","http://dx.doi.org/10.1016/0092-8674(91)90557-F"]
["g_E2F_E2F_RNAp","→","g_E2F_E2F+RNAp+E2F","--","--","8.219e-02 ± 6.974e-17 ","http://dx.doi.org/10.1016/S0304-419X(02)00051-3","http://dx.doi.org/10.1016/0092-8674(91)90557-F"]
[]
[]
["// CA2+ increases in response to ATP -"]
[]
["// THIS MODULE IS THE CA2+ DYNAMICS IN A CELL"]
["// Reactions are taken from"]
["// Lemon et al."," J.Theor. Biol. 223"," 93-111",2003,null,null,"doi:10.1016/S0022-5193(03)00079-1    "]
["// Bhalla et al."," Science 283"," 381-381",1999,null,null,"https://www.sciencemag.org/cgi/content/full/297/5583/1018"]
["// Doi et al."," J. Neuroscience 25(4)"," 950-961",2005,null,null,"http://www.jneurosci.org/cgi/content/abstract/25/4/950"]
["//"]
["// P2X3 module (ATPx ----> P2X3open) //"]
["// Elena Sokolova"," et al. (2006) Molecular Pharmachology 70:373-382 //",{"$nulls":4},"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R1_ATPx_binding_P2X3","ATPx+P2X3","ATP_P2X3","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R3_ATPx_binding_ATP_P2X3","ATPx+ATP_P2X3","ATP2_P2X3","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R5_ATPx_binding_ATP2_P2X3","ATPx+ATP2_P2X3","ATP3_P2X3","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R7_ATP3_P2X3_gating","ATP3_P2X3","P2X3open","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R9_P2X3_desensitization","P2X3","P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R11_ATP_P2X3_desensitization","ATP_P2X3","ATP_P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R13_ATP2_P2X3_desensitization","ATP2_P2X3","ATP2_P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R15_ATP3_P2X3_desensitization","ATP3_P2X3","ATP3_P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R17_P2X3open_desensitization","P2X3open","ATP3_P2X3df","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R19_ATPx_binding_P2X3d","ATPx+P2X3d","ATP_P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R21_ATPx_binding_ATP_P2X3d","ATPx+ATP_P2X3d","ATP2_P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R23_ATPx_binding_ATP2_P2X3d","ATPx+ATP2_P2X3d","ATP3_P2X3d","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["//R25_ATP3_P2X3d_to_ATP3_P2X3df","ATP3_P2X3d","ATP3_P2X3df","-inf","inf;",null,"http://molpharm.aspetjournals.org/cgi/content/abstract/70/1/373"]
["// BLR1-Gprotein module (ATPx -----> Gqa_GTP) //"]
["// Lemon et al. (2003) J.Theor. Biol. 223:93-111//"]
["// Bhalla et al."," Science 283"," 381-381"," 1999 //",null,null,"http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["ATPx+BLR1","↔","ATP_BLR1","6.872e+01 ± 0.000e+00","2.512e+01 ± 3.571e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["ATP_BLR1","↔","ATP_BLR1act","2.658e+01 ± 0.000e+00","2.539e+01 ± 3.928e-14"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["ATP_BLR1act+Gq_GDP","↔","ATP_BLR1_Gq","8.770e+01 ± 1.285e-13","2.573e+01 ± 3.928e-14"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["ATP_BLR1_Gq","→","Gqa_GTP+Gbg+ATP_BLR1","--","--","4.852e+01 ± 8.569e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["Gq_GDP","→","Gqa_GTP+Gbg","--","--","0.000e+00 ± 0.000e+00 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["Gqa_GTP","→","Gqa_GDP","--","--","2.561e+01 ± 4.285e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["Gqa_GDP+Gbg","→","Gq_GDP","--","--","1.535e+01 ± 2.321e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["// PLC-IP3 module (Gqa_GTP -----> IP3) //"]
["// Bhalla et al."," Science 283"," 381-381"," 1999 //"]
["PLCb+CAi","↔","PLCb_Ca","3.746e+01 ± 4.999e-14","5.559e+00 ± 0.000e+00"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb+Gqa_GTP","↔","PLCb_Gq","0.000e+00 ± 0.000e+00","2.410e+01 ± 1.428e-14"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca+Gqa_GTP","↔","PLCb_Ca_Gq","3.018e+01 ± 6.427e-14","2.557e+01 ± 5.356e-14"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Gq+CAi","↔","PLCb_Ca_Gq","8.624e+01 ± 8.569e-14","2.547e+01 ± 4.285e-14"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Gq","→","PLCb+Gqa_GDP","--","--","2.351e+01 ± 4.642e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca_Gq","→","PLCb_Ca+Gqa_GDP","--","--","2.554e+01 ± 3.928e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca_Gq+PIP2","↔","PLCb_Ca_Gq_PIP2","8.189e+01 ± 0.000e+00","2.501e+01 ± 7.141e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca+PIP2","↔","PLCb_Ca_PIP2","7.716e+00 ± 7.141e-15","1.788e+01 ± 3.928e-14"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca_PIP2","→","PLCb_Ca+IP3+DAG","--","--","0.000e+00 ± 0.000e+00 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca_Gq_PIP2","→","PLCb_Ca_Gq+IP3+DAG","--","--","1.999e+01 ± 3.214e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["PLCb_Ca_Gq_PIP2","→","PLCb_Ca_PIP2+Gqa_GDP","--","--","1.489e+01 ± 1.607e-14 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
[]
["IP3","↔","IPx","--","--","7.867e-01 ± 1.339e-15 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IPx","↔","PIP2","--","--","3.546e-01 ± 4.463e-16 ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["// IP3R module (IP3"," CAi -----> IP3Ropen) //"]
["IP3R+IP3","↔","IP3R_IP3","8.285e-01 ± 1.116e-15","7.546e+00 ± 6.249e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3","↔","IP3R_IP3a","9.376e-01 ± 5.579e-16","5.027e-01 ± 5.579e-16"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3a+CAi","↔","IP3R_IP3_CA","9.944e-01 ± 1.451e-15","3.385e+00 ± 8.480e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3_CA","↔","IP3Ropen","3.884e-01 ± 0.000e+00","4.149e+00 ± 9.819e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3_CA+CAi","↔","IP3R_IP3_2CA","5.959e-01 ± 7.811e-16","5.887e+00 ± 2.678e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3_2CA","↔","IP3Ri","3.539e-01 ± 7.811e-16","3.286e-01 ± 5.579e-17"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3_2CA+CAi","↔","IP3R_IP3_3CA","7.810e-01 ± 4.463e-16","2.762e+00 ± 8.927e-16"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["IP3R_IP3_3CA","↔","IP3Rii","1.024e-01 ± 0.000e+00","1.156e+00 ± 1.562e-15"," -- ","http://www.sciencemag.org/cgi/content/full/283/5400/381","http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735677"]
["// ********************************************************** //"]
["// CAi influx module (CAx"," CAs -----> CAi) //"]
["// ...Doi et al. (2005) J. Neuroscience 25:950-961 //"]
["P2X3open+CAx","↔","P2X3open+CAi","6.880e-01 ± 2.232e-16","9.669e+00 ± 1.607e-14"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["IP3Ropen+CAs","↔","IP3Ropen+CAi","4.248e-01 ± 4.463e-16","8.864e+00 ± 1.785e-14"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["Leak_er+CAs","↔","Leak_er+CAi","8.313e-01 ± 1.116e-15","4.368e+00 ± 8.034e-15"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["Leak_x+CAx","↔","Leak_x+CAi","8.754e-02 ± 0.000e+00","6.754e+00 ± 8.927e-15"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["// SERCA module (CAi -----> CAs)"]
["SERCA+2.0*CAi","↔","SERCA_2Ca","3.769e-01 ± 7.253e-16","5.968e+00 ± 0.000e+00"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["SERCA_2Ca","→","SERCA+2.0*CAs","--","--","7.183e-01 ± 6.695e-16 ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["// PMCA module (CAi -----> CAx)"]
["PMCA+CAi","↔","PMCA_Ca","8.284e-01 ± 1.227e-15","1.616e+00 ± 2.009e-15"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["PMCA_Ca","→","PMCA+CAx","--","--","5.783e-01 ± 1.116e-16 ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["// NCX module (CAi -----> CAx)"]
["NCX+2.0*CAi","↔","NCX_2Ca","7.033e-01 ± 1.227e-15","2.631e+00 ± 2.232e-15"," -- ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
["NCX_2Ca","→","NCX+2.0*CAx","--","--","2.023e-01 ± 2.232e-16 ","http://www.jneurosci.org/cgi/content/full/25/4/950"]
[]
[]
["//**************************** Akt Pathway **************************************************************"]
["// TOR kinase part upstream of Merrick paper. "]
["//GF reacts binds with receptor and activates it"]
["//Another route involves Shc and GAB"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos+GAB","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB","7.507e-01 ± 1.116e-15","5.800e+00 ± 8.927e-16"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB+Ras_GDP","↔","EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB_Ras_GDP","2.639e-01 ± 4.463e-16","6.131e+00 ± 1.071e-14"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB_Ras_GDP","→","EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","--","--","9.165e-02 ± 2.511e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// Activated receptor EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP or EGFR_EGF_2_p_Grb2_Sos_Ras_GTP activates PI3K and recruits it to the membrane"]
["PI3K+EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","↔","PI3K_EGFR_EGF_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","9.922e-02 ± 0.000e+00","8.963e+00 ± 8.927e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PI3K+EGFR_EGF_2_p_Grb2_Sos_Ras_GTP","↔","PI3K_EGFR_EGF_2_p_Grb2_Sos_Ras_GTP","3.037e-01 ± 5.021e-16","5.082e+00 ± 6.249e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PI3K_EGFR_EGF_2_p_Grb2_Sos_Ras_GTP","↔","Act_PI3K+EGFR_EGF_2_p_Grb2_Sos_Ras_GTP","5.985e-01 ± 4.463e-16","2.437e+00 ± 4.910e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// Grb2 and then SOS"," or Grb2_Sos complex can bind to Her2_2_p"]
["Grb2+Sos","↔","Grb2_Sos","5.677e-01 ± 5.579e-16","4.246e+00 ± 4.463e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p+Grb2","↔","Her2_2_p_Grb2","5.811e-01 ± 7.811e-16","5.223e+00 ± 1.785e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Grb2+Sos","↔","Her2_2_p_Grb2_Sos","6.845e-01 ± 7.811e-16","1.894e+00 ± 0.000e+00"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p+Grb2_Sos","↔","Her2_2_p_Grb2_Sos","4.272e-01 ± 6.137e-16","1.177e-01 ± 9.763e-17"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Ras+GDP","↔","Ras_GDP","9.583e-01 ± 1.004e-15","6.343e+00 ± 0.000e+00"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Grb2_Sos+Ras_GDP","↔","Her2_2_p_Grb2_Sos_Ras_GDP","9.755e-01 ± 3.347e-16","6.581e+00 ± 7.141e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Grb2_Sos_Ras_GDP","→","Her2_2_p_Grb2_Sos_Ras_GTP","--","--","1.957e-01 ± 8.369e-17 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//Another route involves Shc_p and GAB"]
["Her2_2_p+Shc_p","↔","Her2_2_p_Shc_p","4.191e-01 ± 2.232e-16","3.108e+00 ± 4.463e-16"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Shc_p+Grb2","↔","Her2_2_p_Shc_p_Grb2","1.458e-01 ± 2.232e-16","4.838e+00 ± 6.249e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Shc_p_Grb2+Sos","↔","Her2_2_p_Shc_p_Grb2_Sos","6.360e-01 ± 1.116e-15","4.669e+00 ± 8.927e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Shc_p+Grb2_Sos","↔","Her2_2_p_Shc_p_Grb2_Sos","2.205e-01 ± 4.463e-16","2.731e+00 ± 2.678e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Shc_p_Grb2_Sos+GAB","↔","Her2_2_p_Shc_p_Grb2_Sos_GAB","5.141e-01 ± 1.116e-15","9.129e+00 ± 5.356e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Shc_p_Grb2_Sos_GAB+Ras_GDP","↔","Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GDP","4.571e-02 ± 2.790e-17","1.904e+00 ± 1.785e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GDP","→","Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","--","--","9.642e-01 ± 8.927e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// Activated receptor Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP or Her2_2_p_Grb2_Sos_Ras_GTP activates PI3K and recruits it to the membrane"]
["PI3K+Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","↔","PI3K_Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","6.285e-01 ± 7.811e-16","4.232e+00 ± 7.141e-15"," -- "]
["PI3K+Her2_2_p_Grb2_Sos_Ras_GTP","↔","PI3K_Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","7.144e-01 ± 3.347e-16","1.347e+00 ± 1.562e-15"," -- "]
["PI3K_Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","↔","Act_PI3K+Her2_2_p_Shc_p_Grb2_Sos_GAB_Ras_GTP","2.936e-01 ± 5.579e-16","7.723e+00 ± 1.428e-14"," -- "]
["// Activated PI3K can activate Akt and Pdk via PtdIns"," i.e. PtdIns-diphosphate to PtdIns-triphosphate",{"$nulls":4},"http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PtdIns2+Act_PI3K","↔","PtdIns2_Act_PI3K","8.276e-01 ± 0.000e+00","1.121e+00 ± 1.785e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PtdIns2_Act_PI3K","→","PtdIns3+Act_PI3K","--","--","6.204e-01 ± 2.232e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//PtdIns3 to PtdIns2 is catalyzed by PTEN"]
["PtdIns3+PTEN","↔","PtdIns3_PTEN","8.711e-01 ± 1.227e-15","2.961e-01 ± 3.905e-16"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PtdIns3_PTEN","→","PtdIns2+PTEN","--","--","3.913e-01 ± 3.347e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// PtdIns3 serves to recruit Akt and Pdk1 to the membrane where Pdk1 activates (phosphorylates) Akt1"]
["PtdIns3+Akt","↔","PtdIns3_Akt","1.341e-01 ± 0.000e+00","4.918e+00 ± 9.819e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PtdIns3_Akt","→","PtdIns3+Akt_m","--","--","6.400e-01 ± 1.674e-15 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PtdIns3+Pdk1","↔","PtdIns3_Pdk1","7.665e-01 ± 4.463e-16","7.777e+00 ± 8.927e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["PtdIns3_Pdk1","→","PtdIns3+Pdk1_m","--","--","2.308e-01 ± 3.905e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// Pdk1_m (membrane recruited) now phosphorylates Akt_m"]
["Pdk1_m+Akt_m","↔","Pdk1_m_Akt_m","1.518e-01 ± 2.511e-16","8.489e+00 ± 1.785e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Pdk1_m_Akt_m","→","Pdk1+Act_Akt","--","--","5.557e-01 ± 4.463e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// Act_Akt does a lot of things"," one of which is to activate TOR kinase"]
["// Act_Akt activating TOR directly"]
["Act_Akt+TOR","↔","Act_Akt_TOR","2.887e-02 ± 6.276e-17","5.050e+00 ± 7.141e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Act_Akt_TOR","↔","Akt+Act_TOR","5.041e-01 ± 1.227e-15","6.050e-01 ± 5.579e-16"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//Act_Akt activating TOR via the TSC complex"," "]
["TSC1+TSC2","↔","TSC1_TSC2","1.046e-01 ± 1.674e-16","5.416e+00 ± 5.356e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//TSC complex catalyzes RheB_GTP to RheB_GDP"," Rheb_GTP activates TOR"]
["Rheb_GTP+TSC1_TSC2","↔","Rheb_GTP_TSC1_TSC2","1.197e-01 ± 1.116e-16","1.321e+00 ± 1.562e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Rheb_GTP_TSC1_TSC2","↔","Rheb_GDP+TSC1_TSC2","2.826e-01 ± 5.579e-17","5.763e+00 ± 5.356e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//Rheb_GTP activates TOR and Act_Akt phosporylates TSC1_TSC2 complex by phosphorylating TSC2"]
["Rheb_GTP+TOR","↔","Rheb_GTP_TOR","7.653e-01 ± 1.562e-15","8.928e-01 ± 1.339e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Rheb_GTP_TOR","→","Rheb_GTP+Act_TOR","--","--","9.894e-01 ± 1.339e-15 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["TSC1_TSC2+Act_Akt","↔","TSC1_TSC2_Act_Akt","9.721e-01 ± 1.227e-15","9.846e+00 ± 1.071e-14"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["TSC1_TSC2_Act_Akt","→","TSC1_TSC2_P+Act_Akt","--","--","9.410e-01 ± 1.897e-15 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//Act_TOR phosphorylates and inactivates 4E-BP1"," hypophosphorylated 4E-BP1 combines and sequesters eIF4E"]
["4E_BP1+eIF4E","↔","4E_BP1_eIF4E","5.094e-01 ± 1.116e-15","8.434e+00 ± 1.607e-14"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["4E_BP1+Act_TOR","↔","4E_BP1_Act_TOR","1.731e-01 ± 0.000e+00","7.377e+00 ± 1.428e-14"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["4E_BP1_Act_TOR","→","4E_BP1_P+Act_TOR","--","--","4.473e-01 ± 5.579e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// Act_TOR releases eIF4E by disruption of 4E-BP1 in the dimer (new reactions added)"]
["4E_BP1_eIF4E+Act_TOR","↔","4E_BP1_eIF4E_Act_TOR","5.284e-01 ± 4.463e-16","2.380e+00 ± 3.571e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["4E_BP1_eIF4E_Act_TOR","→","4E_BP1_P+eIF4E+Act_TOR","--","--","7.537e-01 ± 7.811e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["// 40S_inact is activated by p70S6K (by phosphorylation)"," which inturn"," is activated by Act_TOR (by phosphorylation)"]
["p70+Act_TOR","↔","p70_Act_TOR","7.262e-01 ± 7.811e-16","2.676e+00 ± 3.571e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["p70_Act_TOR","→","Act_p70+Act_TOR","--","--","5.116e-01 ± 7.811e-16 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Act_p70+40S_inact","↔","Act_p70_40S_inact","5.061e-01 ± 5.579e-16","8.671e+00 ± 5.356e-15"," -- ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["Act_p70_40S_inact","→","Act_p70+40S","--","--","6.072e-01 ± 1.004e-15 ","http://www.sciencemag.org/cgi/content/abstract/296/5573/1655"]
["//*******************************IC formation part ******************************************************************"]
["// Initiation network from the Wagner Review and Merrick paper"]
["// Formation of ternary complex"]
["eIF2+GTP","↔","eIF2_GTP","6.930e-01 ± 3.347e-16","7.104e+00 ± 1.071e-14"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["eIF2_GTP+met_tRNA","↔","eIF2_GTP_met_tRNA","7.387e-01 ± 1.785e-15","4.040e+00 ± 8.927e-16"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["// Formation of 40S sub-unit ready for association with ternary complex"]
["// IFs required are eIF3","eIF1 and eIF1A"]
["40S+eIF3","↔","40S_eIF3","9.330e-01 ± 7.811e-16","1.476e+00 ± 6.695e-16"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["40S_eIF3+eIF1","↔","40S_eIF3_eIF1","4.479e-01 ± 1.674e-16","9.517e+00 ± 1.785e-14"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["40S_eIF3_eIF1+eIF1A","↔","40S_eIF3_eIF1_eIF1A","4.249e-02 ± 5.579e-17","7.783e-01 ± 5.579e-16"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["eIF5+eIF5B","↔","eIF5_eIF5B","5.476e-01 ± 7.811e-16","6.705e+00 ± 5.356e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["40S_eIF3_eIF1_eIF1A+eIF5_eIF5B","↔","40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","2.066e-01 ± 2.790e-17","2.698e+00 ± 2.232e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["// Remember all the components of 43S"]
["// Association of ternary complex and 40S sun-unit to form 43S"]
["// Remember all the components of 43S"]
["eIF2_GTP_met_tRNA+40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","2.792e-01 ± 2.232e-16","6.622e-02 ± 1.534e-16"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["// Association of Cap-binding complex to mRNA"," eIF4s involved"]
["// Main complex is called eIF4F complex"]
["// eIF4G is the scaffold on which eIF4A and eIF4E combine to form eIF4F"]
["// Remember all components of eIF4F"]
["eIF4A+eIF4G+eIF4E","↔","eIF4A_eIF4G_eIF4E","5.144e-01 ± 2.232e-16","9.388e+00 ± 3.571e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["// Additional eIF4B and eIF4H help eIF4A"," the total complex is called Cap-binding-complex (CBC)"]
["eIF4A_eIF4G_eIF4E+eIF4B+eIF4H","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H","1.376e-01 ± 3.068e-16","6.729e+00 ± 1.160e-14"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["// TSC1 and TSC2 activity occur in the absence of the complex - (Garami Mol. Cell 11:1457 - 1466"," 2003)"]
["Rheb_GTP+TSC1","↔","Rheb_GTP_TSC1","7.904e-02 ± 0.000e+00","8.855e+00 ± 1.428e-14"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["Rheb_GTP_TSC1","→","Rheb_GDP+TSC1","--","--","6.517e-01 ± 1.004e-15 ","doi:10.1016/j.gene.2004.02.051    "]
["Rheb_GTP+TSC2","↔","Rheb_GTP_TSC2","1.292e-01 ± 8.369e-17","5.146e+00 ± 6.249e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["Rheb_GTP_TSC2","→","Rheb_GDP+TSC2","--","--","9.090e-01 ± 1.785e-15 ","doi:10.1016/j.gene.2004.02.051    "]
["// Phosphorylation of TSC1 by Akt"]
["TSC1+Act_Akt","↔","TSC1_Act_Akt","9.028e-01 ± 2.232e-16","2.478e+00 ± 5.356e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["TSC1_Act_Akt","→","TSC1_P+Act_Akt","--","--","6.006e-02 ± 0.000e+00 ","doi:10.1016/j.gene.2004.02.051    "]
["// Phosphorylation of TSC2 by Akt"]
["TSC2+Act_Akt","↔","TSC2_Act_Akt","1.335e-01 ± 1.953e-16","9.735e+00 ± 1.785e-14"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["TSC2_Act_Akt","→","TSC2_P+Act_Akt","--","--","4.405e-01 ± 6.137e-16 ","doi:10.1016/j.gene.2004.02.051    "]
["// Exchange between Rheb_GTP and Rheb_GDP"]
["Rheb_GTP","↔","Rheb_GDP","6.980e-01 ± 1.339e-15","2.302e+00 ± 3.571e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["// Deactivation of mTOR"]
["Act_TOR","→","TOR","--","--","2.115e-01 ± 3.347e-16 ","doi:10.1016/j.gene.2004.02.051    "]
["// Rheb binding of GTP and GDP -"]
["Rheb+GDP","↔","Rheb_GDP","1.312e-01 ± 0.000e+00","2.013e+00 ± 1.339e-15"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["Rheb+GTP","↔","Rheb_GTP","6.434e-01 ± 1.227e-15","9.226e+00 ± 1.071e-14"," -- ","doi:10.1016/j.gene.2004.02.051    "]
["//********************************************************************************************************//"]
["// Transcription Translation Network "]
["// Generated by transNet"]
["//  "]
["//  "]
["// Transcription:"]
["//  Data about genes and transcription factors is from Andy's powerblot paper"]
["//  "]
["// Oct1"]
["g_Oct1+RNAp","↔","g_Oct1_RNAp","3.527e-01 ± 8.927e-16","1.590e+00 ± 0.000e+00"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1_RNAp","→","g_Oct1+RNAp+Cap_mRNA_n_Oct1","--","--","8.374e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1+RA_RAR","↔","g_Oct1_RA_RAR","8.660e-01 ± 0.000e+00","4.158e+00 ± 8.927e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1_RA_RAR+RNAp","↔","g_Oct1_RA_RAR_RNAp","6.841e-01 ± 1.451e-15","2.669e+00 ± 2.232e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1_RA_RAR_RNAp","→","g_Oct1_RA_RAR+RNAp+Cap_mRNA_n_Oct1","--","--","7.141e-01 ± 5.579e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1+RA_RXR","↔","g_Oct1_RA_RXR","5.739e-02 ± 0.000e+00","6.831e+00 ± 9.819e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1_RA_RXR+RNAp","↔","g_Oct1_RA_RXR_RNAp","2.472e-01 ± 4.184e-16","4.603e+00 ± 7.141e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Oct1_RA_RXR_RNAp","→","g_Oct1_RA_RXR+RNAp+Cap_mRNA_n_Oct1","--","--","2.041e-01 ± 1.395e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_Oct1","→","Cap_mRNA_Oct1","--","--","2.831e-01 ± 1.674e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_Oct1","→","[]","--","--","1.473e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Oct1","→","[]","--","--","6.119e-01 ± 1.339e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// CREB"]
["g_CREB+RNAp","↔","g_CREB_RNAp","5.100e-01 ± 4.463e-16","2.515e+00 ± 4.463e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB_RNAp","→","g_CREB+RNAp+Cap_mRNA_n_CREB","--","--","3.648e-01 ± 1.674e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB+RA_RAR","↔","g_CREB_RA_RAR","8.889e-01 ± 0.000e+00","1.203e+00 ± 2.009e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB_RA_RAR+RNAp","↔","g_CREB_RA_RAR_RNAp","2.162e-02 ± 5.928e-17","3.518e+00 ± 2.678e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB_RA_RAR_RNAp","→","g_CREB_RA_RAR+RNAp+Cap_mRNA_n_CREB","--","--","6.166e-02 ± 6.974e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB+RA_RXR","↔","g_CREB_RA_RXR","6.956e-01 ± 2.232e-16","2.391e+00 ± 3.124e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB_RA_RXR+RNAp","↔","g_CREB_RA_RXR_RNAp","5.586e-01 ± 8.927e-16","5.124e+00 ± 7.141e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CREB_RA_RXR_RNAp","→","g_CREB_RA_RXR+RNAp+Cap_mRNA_n_CREB","--","--","5.888e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_CREB","→","Cap_mRNA_CREB","--","--","5.853e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_CREB","→","[]","--","--","5.365e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["CREB","→","[]","--","--","7.633e-02 ± 1.674e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// ETS"]
["g_ETS+RNAp","↔","g_ETS_RNAp","2.108e-01 ± 8.369e-17","9.977e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS_RNAp","→","g_ETS+RNAp+Cap_mRNA_n_ETS","--","--","5.977e-01 ± 4.463e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS+RA_RAR","↔","g_ETS_RA_RAR","7.326e-01 ± 6.695e-16","4.122e-01 ± 0.000e+00"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS_RA_RAR+RNAp","↔","g_ETS_RA_RAR_RNAp","3.106e-01 ± 6.695e-16","3.698e+00 ± 4.463e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS_RA_RAR_RNAp","→","g_ETS_RA_RAR+RNAp+Cap_mRNA_n_ETS","--","--","7.518e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS+RA_RXR","↔","g_ETS_RA_RXR","4.480e-01 ± 5.579e-16","7.666e+00 ± 1.160e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS_RA_RXR+RNAp","↔","g_ETS_RA_RXR_RNAp","3.028e-01 ± 5.579e-16","9.805e+00 ± 0.000e+00"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_ETS_RA_RXR_RNAp","→","g_ETS_RA_RXR+RNAp+Cap_mRNA_n_ETS","--","--","4.611e-01 ± 7.811e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_ETS","→","Cap_mRNA_ETS","--","--","8.147e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_ETS","→","[]","--","--","6.843e-01 ± 4.463e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["ETS","→","[]","--","--","4.202e-02 ± 1.186e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// BRN"]
["g_BRN+RNAp","↔","g_BRN_RNAp","9.159e-01 ± 1.116e-16","1.007e+00 ± 2.455e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN_RNAp","→","g_BRN+RNAp+Cap_mRNA_n_BRN","--","--","5.747e-03 ± 0.000e+00 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN+RA_RAR","↔","g_BRN_RA_RAR","3.729e-01 ± 1.116e-16","9.266e+00 ± 1.785e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN_RA_RAR+RNAp","↔","g_BRN_RA_RAR_RNAp","5.827e-01 ± 7.811e-16","5.811e+00 ± 1.250e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN_RA_RAR_RNAp","→","g_BRN_RA_RAR+RNAp+Cap_mRNA_n_BRN","--","--","1.717e-01 ± 2.232e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN+RA_RXR","↔","g_BRN_RA_RXR","4.817e-01 ± 6.695e-16","2.584e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN_RA_RXR+RNAp","↔","g_BRN_RA_RXR_RNAp","1.671e-01 ± 2.232e-16","5.399e+00 ± 1.071e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_BRN_RA_RXR_RNAp","→","g_BRN_RA_RXR+RNAp+Cap_mRNA_n_BRN","--","--","6.154e-02 ± 5.579e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_BRN","→","Cap_mRNA_BRN","--","--","7.880e-02 ± 9.763e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_BRN","→","[]","--","--","9.597e-01 ± 2.232e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["BRN","→","[]","--","--","3.174e-01 ± 5.021e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// IRF"]
["g_IRF+RNAp","↔","g_IRF_RNAp","5.713e-01 ± 1.116e-15","2.404e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_RNAp","→","g_IRF+RNAp+Cap_mRNA_n_IRF","--","--","7.478e-01 ± 1.562e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF+Oct1_p","↔","g_IRF_Oct1_p","3.776e-01 ± 5.579e-17","5.551e+00 ± 1.785e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_Oct1_p+RNAp","↔","g_IRF_Oct1_p_RNAp","1.980e-01 ± 5.579e-17","1.943e+00 ± 4.463e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_Oct1_p_RNAp","→","g_IRF_Oct1_p+RNAp+Cap_mRNA_n_IRF","--","--","4.334e-01 ± 5.021e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF+CREB_p","↔","g_IRF_CREB_p","6.107e-01 ± 1.004e-15","4.206e+00 ± 4.463e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_CREB_p+RNAp","↔","g_IRF_CREB_p_RNAp","1.844e-01 ± 5.021e-16","7.303e+00 ± 1.250e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_CREB_p_RNAp","→","g_IRF_CREB_p+RNAp+Cap_mRNA_n_IRF","--","--","1.597e-01 ± 1.953e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF+ETS_p","↔","g_IRF_ETS_p","1.245e-01 ± 1.116e-16","9.312e+00 ± 8.927e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_ETS_p+RNAp","↔","g_IRF_ETS_p_RNAp","3.532e-01 ± 5.579e-16","2.454e+00 ± 4.463e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_ETS_p_RNAp","→","g_IRF_ETS_p+RNAp+Cap_mRNA_n_IRF","--","--","9.614e-01 ± 2.232e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF+BRN_p","↔","g_IRF_BRN_p","6.349e-02 ± 1.674e-16","2.563e+00 ± 2.232e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_BRN_p+RNAp","↔","g_IRF_BRN_p_RNAp","8.277e-01 ± 2.120e-15","9.137e+00 ± 8.927e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_IRF_BRN_p_RNAp","→","g_IRF_BRN_p+RNAp+Cap_mRNA_n_IRF","--","--","2.286e-01 ± 2.790e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_IRF","→","Cap_mRNA_IRF","--","--","5.451e-01 ± 1.116e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_IRF","→","[]","--","--","1.227e-01 ± 1.953e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["IRF","→","[]","--","--","4.536e-01 ± 2.790e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// SRPK"]
["g_SRPK+RNAp","↔","g_SRPK_RNAp","8.453e-01 ± 4.463e-16","9.796e+00 ± 1.607e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_RNAp","→","g_SRPK+RNAp+Cap_mRNA_n_SRPK","--","--","8.977e-01 ± 2.232e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK+Oct1_p","↔","g_SRPK_Oct1_p","3.629e-01 ± 2.232e-16","5.115e+00 ± 1.071e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_Oct1_p+RNAp","↔","g_SRPK_Oct1_p_RNAp","1.500e-01 ± 3.068e-16","2.706e+00 ± 7.141e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_Oct1_p_RNAp","→","g_SRPK_Oct1_p+RNAp+Cap_mRNA_n_SRPK","--","--","4.728e-01 ± 2.790e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK+CREB_p","↔","g_SRPK_CREB_p","2.315e-01 ± 1.395e-16","2.837e+00 ± 4.463e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_CREB_p+RNAp","↔","g_SRPK_CREB_p_RNAp","4.883e-01 ± 1.116e-16","9.893e+00 ± 1.428e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_CREB_p_RNAp","→","g_SRPK_CREB_p+RNAp+Cap_mRNA_n_SRPK","--","--","6.610e-02 ± 1.534e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK+ETS_p","↔","g_SRPK_ETS_p","1.810e-01 ± 3.347e-16","3.606e+00 ± 2.678e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_ETS_p+RNAp","↔","g_SRPK_ETS_p_RNAp","9.942e-01 ± 8.927e-16","2.750e-01 ± 4.463e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_ETS_p_RNAp","→","g_SRPK_ETS_p+RNAp+Cap_mRNA_n_SRPK","--","--","3.501e-01 ± 9.484e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK+BRN_p","↔","g_SRPK_BRN_p","5.130e-01 ± 5.579e-16","1.789e+00 ± 2.678e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_BRN_p+RNAp","↔","g_SRPK_BRN_p_RNAp","4.332e-02 ± 8.369e-17","1.400e-01 ± 1.953e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SRPK_BRN_p_RNAp","→","g_SRPK_BRN_p+RNAp+Cap_mRNA_n_SRPK","--","--","3.881e-01 ± 2.232e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_SRPK","→","Cap_mRNA_SRPK","--","--","8.564e-01 ± 5.579e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_SRPK","→","[]","--","--","5.945e-01 ± 1.227e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["SRPK","→","[]","--","--","2.948e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// pRb"]
["g_pRb+RNAp","↔","g_pRb_RNAp","9.727e-01 ± 2.232e-15","8.258e+00 ± 1.607e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_RNAp","→","g_pRb+RNAp+Cap_mRNA_n_pRb","--","--","1.970e-01 ± 2.790e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb+Oct1_p","↔","g_pRb_Oct1_p","5.472e-01 ± 8.927e-16","5.563e+00 ± 2.678e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_Oct1_p+RNAp","↔","g_pRb_Oct1_p_RNAp","7.163e-01 ± 1.116e-16","2.410e+00 ± 3.571e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_Oct1_p_RNAp","→","g_pRb_Oct1_p+RNAp+Cap_mRNA_n_pRb","--","--","5.085e-01 ± 7.811e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb+CREB_p","↔","g_pRb_CREB_p","4.393e-01 ± 1.004e-15","2.563e-01 ± 2.790e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_CREB_p+RNAp","↔","g_pRb_CREB_p_RNAp","8.275e-01 ± 2.232e-16","6.597e+00 ± 1.160e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_CREB_p_RNAp","→","g_pRb_CREB_p+RNAp+Cap_mRNA_n_pRb","--","--","3.978e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb+ETS_p","↔","g_pRb_ETS_p","1.861e-01 ± 2.790e-16","1.498e+00 ± 4.463e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_ETS_p+RNAp","↔","g_pRb_ETS_p_RNAp","9.528e-01 ± 2.232e-15","8.874e+00 ± 1.428e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_ETS_p_RNAp","→","g_pRb_ETS_p+RNAp+Cap_mRNA_n_pRb","--","--","6.410e-01 ± 5.579e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb+BRN_p","↔","g_pRb_BRN_p","6.547e-01 ± 7.811e-16","8.465e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_BRN_p+RNAp","↔","g_pRb_BRN_p_RNAp","4.203e-01 ± 3.905e-16","9.352e-01 ± 1.451e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_pRb_BRN_p_RNAp","→","g_pRb_BRN_p+RNAp+Cap_mRNA_n_pRb","--","--","6.897e-01 ± 5.579e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_pRb","→","Cap_mRNA_pRb","--","--","4.171e-01 ± 0.000e+00 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_pRb","→","[]","--","--","2.872e-01 ± 2.790e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["pRb","→","[]","--","--","8.049e-01 ± 0.000e+00 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// RhoGDI"]
["g_RhoGDI+RNAp","↔","g_RhoGDI_RNAp","5.919e-01 ± 1.227e-15","1.608e+00 ± 0.000e+00"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_RNAp","→","g_RhoGDI+RNAp+Cap_mRNA_n_RhoGDI","--","--","8.109e-01 ± 1.116e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI+Oct1_p","↔","g_RhoGDI_Oct1_p","5.757e-02 ± 4.882e-17","2.075e+00 ± 4.017e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_Oct1_p+RNAp","↔","g_RhoGDI_Oct1_p_RNAp","9.901e-01 ± 5.579e-16","6.165e+00 ± 1.071e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_Oct1_p_RNAp","→","g_RhoGDI_Oct1_p+RNAp+Cap_mRNA_n_RhoGDI","--","--","6.788e-01 ± 1.339e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI+CREB_p","↔","g_RhoGDI_CREB_p","6.437e-01 ± 6.695e-16","8.404e+00 ± 1.785e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_CREB_p+RNAp","↔","g_RhoGDI_CREB_p_RNAp","9.836e-01 ± 1.562e-15","8.205e+00 ± 1.428e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_CREB_p_RNAp","→","g_RhoGDI_CREB_p+RNAp+Cap_mRNA_n_RhoGDI","--","--","6.501e-01 ± 1.339e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI+ETS_p","↔","g_RhoGDI_ETS_p","2.491e-01 ± 2.232e-16","2.031e+00 ± 2.232e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_ETS_p+RNAp","↔","g_RhoGDI_ETS_p_RNAp","3.162e-02 ± 7.671e-17","4.016e+00 ± 2.678e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_ETS_p_RNAp","→","g_RhoGDI_ETS_p+RNAp+Cap_mRNA_n_RhoGDI","--","--","2.487e-01 ± 2.232e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI+BRN_p","↔","g_RhoGDI_BRN_p","6.929e-03 ± 0.000e+00","2.729e-01 ± 3.905e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_BRN_p+RNAp","↔","g_RhoGDI_BRN_p_RNAp","6.135e-01 ± 7.811e-16","9.219e+00 ± 2.142e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_RhoGDI_BRN_p_RNAp","→","g_RhoGDI_BRN_p+RNAp+Cap_mRNA_n_RhoGDI","--","--","5.579e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_RhoGDI","→","Cap_mRNA_RhoGDI","--","--","4.552e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_RhoGDI","→","[]","--","--","8.576e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["RhoGDI","→","[]","--","--","8.596e-03 ± 0.000e+00 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// P47phox"]
["g_P47phox+RNAp","↔","g_P47phox_RNAp","1.944e-01 ± 2.790e-16","3.951e+00 ± 1.339e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_RNAp","→","g_P47phox+RNAp+Cap_mRNA_n_P47phox","--","--","6.654e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox+Oct1_p","↔","g_P47phox_Oct1_p","2.505e-02 ± 6.625e-17","1.074e+00 ± 1.562e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_Oct1_p+RNAp","↔","g_P47phox_Oct1_p_RNAp","2.847e-01 ± 5.579e-17","5.110e+00 ± 1.339e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_Oct1_p_RNAp","→","g_P47phox_Oct1_p+RNAp+Cap_mRNA_n_P47phox","--","--","4.581e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox+CREB_p","↔","g_P47phox_CREB_p","3.951e-01 ± 0.000e+00","4.624e+00 ± 8.034e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_CREB_p+RNAp","↔","g_P47phox_CREB_p_RNAp","4.084e-02 ± 1.186e-16","7.317e+00 ± 1.517e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_CREB_p_RNAp","→","g_P47phox_CREB_p+RNAp+Cap_mRNA_n_P47phox","--","--","4.883e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox+ETS_p","↔","g_P47phox_ETS_p","5.380e-01 ± 4.463e-16","9.894e+00 ± 2.142e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_ETS_p+RNAp","↔","g_P47phox_ETS_p_RNAp","8.067e-01 ± 4.463e-16","7.685e+00 ± 8.034e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_ETS_p_RNAp","→","g_P47phox_ETS_p+RNAp+Cap_mRNA_n_P47phox","--","--","3.609e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox+BRN_p","↔","g_P47phox_BRN_p","5.693e-02 ± 8.369e-17","4.734e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_BRN_p+RNAp","↔","g_P47phox_BRN_p_RNAp","3.113e-01 ± 6.137e-16","4.420e+00 ± 6.249e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_P47phox_BRN_p_RNAp","→","g_P47phox_BRN_p+RNAp+Cap_mRNA_n_P47phox","--","--","6.570e-01 ± 8.927e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_P47phox","→","Cap_mRNA_P47phox","--","--","6.212e-01 ± 1.562e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_P47phox","→","[]","--","--","7.860e-02 ± 9.763e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["P47phox","→","[]","--","--","3.006e-01 ± 7.811e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// CD45"]
["g_CD45+RNAp","↔","g_CD45_RNAp","8.456e-01 ± 1.116e-15","3.045e-01 ± 5.021e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_RNAp","→","g_CD45+RNAp+Cap_mRNA_n_CD45","--","--","5.571e-01 ± 1.451e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45+Oct1_p","↔","g_CD45_Oct1_p","3.622e-01 ± 4.463e-16","9.332e+00 ± 1.071e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_Oct1_p+RNAp","↔","g_CD45_Oct1_p_RNAp","5.209e-01 ± 1.116e-16","7.934e+00 ± 1.517e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_Oct1_p_RNAp","→","g_CD45_Oct1_p+RNAp+Cap_mRNA_n_CD45","--","--","7.093e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45+CREB_p","↔","g_CD45_CREB_p","2.512e-01 ± 5.579e-16","6.128e+00 ± 1.785e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_CREB_p+RNAp","↔","g_CD45_CREB_p_RNAp","1.279e-02 ± 0.000e+00","2.009e+00 ± 2.232e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_CREB_p_RNAp","→","g_CD45_CREB_p+RNAp+Cap_mRNA_n_CD45","--","--","2.937e-01 ± 6.137e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45+ETS_p","↔","g_CD45_ETS_p","2.088e-01 ± 3.068e-16","5.237e+00 ± 1.160e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_ETS_p+RNAp","↔","g_CD45_ETS_p_RNAp","2.197e-01 ± 4.463e-16","9.905e+00 ± 1.428e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_ETS_p_RNAp","→","g_CD45_ETS_p+RNAp+Cap_mRNA_n_CD45","--","--","1.880e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45+BRN_p","↔","g_CD45_BRN_p","4.095e-01 ± 6.695e-16","5.812e+00 ± 3.571e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_BRN_p+RNAp","↔","g_CD45_BRN_p_RNAp","1.768e-01 ± 5.579e-17","2.208e+00 ± 4.017e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_CD45_BRN_p_RNAp","→","g_CD45_BRN_p+RNAp+Cap_mRNA_n_CD45","--","--","5.870e-01 ± 8.927e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_CD45","→","Cap_mRNA_CD45","--","--","9.421e-01 ± 1.339e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_CD45","→","[]","--","--","4.239e-01 ± 5.579e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["CD45","→","[]","--","--","5.573e-01 ± 7.811e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// EIF2AK"]
["g_EIF2AK+RNAp","↔","g_EIF2AK_RNAp","1.716e-01 ± 2.232e-16","3.840e+00 ± 4.463e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_RNAp","→","g_EIF2AK+RNAp+Cap_mRNA_n_EIF2AK","--","--","2.682e-01 ± 1.674e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK+Oct1_p","↔","g_EIF2AK_Oct1_p","1.906e-02 ± 0.000e+00","7.321e+00 ± 1.517e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_Oct1_p+RNAp","↔","g_EIF2AK_Oct1_p_RNAp","7.181e-01 ± 7.811e-16","5.341e+00 ± 1.071e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_Oct1_p_RNAp","→","g_EIF2AK_Oct1_p+RNAp+Cap_mRNA_n_EIF2AK","--","--","9.366e-01 ± 4.463e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK+CREB_p","↔","g_EIF2AK_CREB_p","9.377e-01 ± 2.232e-15","4.521e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_CREB_p+RNAp","↔","g_EIF2AK_CREB_p_RNAp","8.858e-01 ± 1.116e-16","3.098e+00 ± 4.463e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_CREB_p_RNAp","→","g_EIF2AK_CREB_p+RNAp+Cap_mRNA_n_EIF2AK","--","--","3.088e-01 ± 3.905e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK+ETS_p","↔","g_EIF2AK_ETS_p","2.940e-01 ± 2.790e-16","9.604e+00 ± 1.785e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_ETS_p+RNAp","↔","g_EIF2AK_ETS_p_RNAp","4.399e-02 ± 0.000e+00","2.627e+00 ± 1.339e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_ETS_p_RNAp","→","g_EIF2AK_ETS_p+RNAp+Cap_mRNA_n_EIF2AK","--","--","5.303e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK+BRN_p","↔","g_EIF2AK_BRN_p","4.383e-01 ± 3.347e-16","7.146e+00 ± 8.034e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_BRN_p+RNAp","↔","g_EIF2AK_BRN_p_RNAp","4.178e-01 ± 4.463e-16","6.052e+00 ± 8.927e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_EIF2AK_BRN_p_RNAp","→","g_EIF2AK_BRN_p+RNAp+Cap_mRNA_n_EIF2AK","--","--","1.870e-01 ± 1.395e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_EIF2AK","→","Cap_mRNA_EIF2AK","--","--","9.484e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_EIF2AK","→","[]","--","--","1.622e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["EIF2AK","→","[]","--","--","7.565e-01 ± 5.579e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// SIIIp15"]
["g_SIIIp15+RNAp","↔","g_SIIIp15_RNAp","1.795e-01 ± 2.232e-16","1.730e+00 ± 2.009e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_RNAp","→","g_SIIIp15+RNAp+Cap_mRNA_n_SIIIp15","--","--","8.268e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15+Oct1_p","↔","g_SIIIp15_Oct1_p","6.159e-01 ± 5.579e-16","2.319e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_Oct1_p+RNAp","↔","g_SIIIp15_Oct1_p_RNAp","1.841e-01 ± 1.953e-16","4.089e+00 ± 6.249e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_Oct1_p_RNAp","→","g_SIIIp15_Oct1_p+RNAp+Cap_mRNA_n_SIIIp15","--","--","2.707e-01 ± 4.463e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15+CREB_p","↔","g_SIIIp15_CREB_p","7.314e-01 ± 1.897e-15","7.065e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_CREB_p+RNAp","↔","g_SIIIp15_CREB_p_RNAp","6.872e-01 ± 2.232e-16","4.013e+00 ± 7.141e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_CREB_p_RNAp","→","g_SIIIp15_CREB_p+RNAp+Cap_mRNA_n_SIIIp15","--","--","4.342e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15+ETS_p","↔","g_SIIIp15_ETS_p","8.839e-01 ± 4.463e-16","7.408e+00 ± 8.034e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_ETS_p+RNAp","↔","g_SIIIp15_ETS_p_RNAp","7.574e-01 ± 1.004e-15","9.817e-01 ± 2.009e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_ETS_p_RNAp","→","g_SIIIp15_ETS_p+RNAp+Cap_mRNA_n_SIIIp15","--","--","4.226e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15+BRN_p","↔","g_SIIIp15_BRN_p","3.369e-01 ± 0.000e+00","4.176e+00 ± 3.571e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_BRN_p+RNAp","↔","g_SIIIp15_BRN_p_RNAp","1.887e-01 ± 8.369e-17","9.356e+00 ± 2.142e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SIIIp15_BRN_p_RNAp","→","g_SIIIp15_BRN_p+RNAp+Cap_mRNA_n_SIIIp15","--","--","3.922e-01 ± 2.790e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_SIIIp15","→","Cap_mRNA_SIIIp15","--","--","9.896e-01 ± 1.562e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_SIIIp15","→","[]","--","--","1.446e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["SIIIp15","→","[]","--","--","8.864e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// AAF"]
["g_AAF+RNAp","↔","g_AAF_RNAp","7.238e-01 ± 2.232e-16","1.485e+00 ± 2.901e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_AAF_RNAp","→","g_AAF+RNAp+Cap_mRNA_n_AAF","--","--","7.236e-01 ± 1.562e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_AAF+BLR1","↔","g_AAF_BLR1","4.147e-01 ± 6.137e-16","6.072e+00 ± 1.785e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_AAF_BLR1+RNAp","↔","g_AAF_BLR1_RNAp","6.892e-01 ± 1.004e-15","7.609e+00 ± 1.785e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_AAF_BLR1_RNAp","→","g_AAF_BLR1+RNAp+Cap_mRNA_n_AAF","--","--","2.416e-01 ± 5.021e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_AAF","→","Cap_mRNA_AAF","--","--","2.367e-01 ± 5.021e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_AAF","→","[]","--","--","5.709e-01 ± 7.811e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["AAF","→","[]","--","--","2.699e-01 ± 3.347e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// Stat5b"]
["g_Stat5b+RNAp","↔","g_Stat5b_RNAp","7.993e-01 ± 2.232e-16","4.484e-01 ± 3.905e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Stat5b_RNAp","→","g_Stat5b+RNAp+Cap_mRNA_n_Stat5b","--","--","2.708e-01 ± 1.674e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Stat5b+BLR1","↔","g_Stat5b_BLR1","1.866e-01 ± 5.579e-17","7.061e+00 ± 6.249e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Stat5b_BLR1+RNAp","↔","g_Stat5b_BLR1_RNAp","9.763e-01 ± 1.674e-15","1.313e+00 ± 2.009e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_Stat5b_BLR1_RNAp","→","g_Stat5b_BLR1+RNAp+Cap_mRNA_n_Stat5b","--","--","2.212e-01 ± 3.068e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_Stat5b","→","Cap_mRNA_Stat5b","--","--","7.178e-01 ± 1.562e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_Stat5b","→","[]","--","--","2.386e-01 ± 8.369e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Stat5b","→","[]","--","--","2.853e-01 ± 2.790e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// XRE"]
["g_XRE+RNAp","↔","g_XRE_RNAp","2.162e-01 ± 4.463e-16","3.246e+00 ± 3.124e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_XRE_RNAp","→","g_XRE+RNAp+Cap_mRNA_n_XRE","--","--","7.536e-01 ± 7.811e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_XRE+BLR1","↔","g_XRE_BLR1","1.731e-01 ± 1.953e-16","1.289e+00 ± 2.232e-16"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_XRE_BLR1+RNAp","↔","g_XRE_BLR1_RNAp","2.373e-01 ± 8.369e-17","5.178e+00 ± 5.356e-15"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_XRE_BLR1_RNAp","→","g_XRE_BLR1+RNAp+Cap_mRNA_n_XRE","--","--","6.295e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_XRE","→","Cap_mRNA_XRE","--","--","2.604e-01 ± 1.674e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_XRE","→","[]","--","--","1.047e-01 ± 9.763e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["XRE","→","[]","--","--","3.504e-01 ± 9.484e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["// SAP"]
["g_SAP+RNAp","↔","g_SAP_RNAp","7.830e-03 ± 0.000e+00","6.331e+00 ± 1.071e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SAP_RNAp","→","g_SAP+RNAp+Cap_mRNA_n_SAP","--","--","9.428e-01 ± 1.785e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SAP+BLR1","↔","g_SAP_BLR1","5.190e-02 ± 1.395e-17","8.388e+00 ± 1.785e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SAP_BLR1+RNAp","↔","g_SAP_BLR1_RNAp","4.828e-01 ± 1.004e-15","9.164e+00 ± 1.428e-14"," -- ","http://www.springerlink.com/content/g166821309010n5n/"]
["g_SAP_BLR1_RNAp","→","g_SAP_BLR1+RNAp+Cap_mRNA_n_SAP","--","--","8.259e-01 ± 1.116e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_n_SAP","→","Cap_mRNA_SAP","--","--","7.035e-02 ± 9.763e-17 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_SAP","→","[]","--","--","6.757e-01 ± 5.579e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["SAP","→","[]","--","--","3.142e-01 ± 6.695e-16 ","http://www.springerlink.com/content/g166821309010n5n/"]
["//"]
["// BLR1 (transcription is above)"]
["Cap_mRNA_n_BLR1","→","Cap_mRNA_BLR1","--","--","9.294e+01 ± 8.569e-14 ","http://www.springerlink.com/content/g166821309010n5n/"]
["Cap_mRNA_BLR1","→","[]","--","--","1.083e+01 ± 1.785e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["BLR1","→","[]","--","--","4.882e-01 ± 1.004e-15 ","http://www.springerlink.com/content/g166821309010n5n/"]
["//  "]
["//  "]
["// Translation:"]
["//  "]
["//  "]
["// poly-A binding protein (PABP) at 3' end of mRNA_Oct1 attaches to the CBC (till now)"," forming a circular mRNA_Oct1"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_Oct1 with a 5'-cap"]
["// PABP joins Cap_mRNA_Oct1 at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_Oct1","↔","Cap_mRNA_Oct1_PABP","7.838e-01 ± 1.451e-15","9.057e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_Oct1_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP","8.504e-01 ± 8.927e-16","5.929e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_Oct1 and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","1.523e-01 ± 0.000e+00","4.285e+00 ± 3.571e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","2.997e-01 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","2.824e-01 ± 1.674e-16","4.480e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","7.387e-01 ± 8.927e-16","5.412e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","9.358e-01 ± 4.463e-16","6.065e-01 ± 1.116e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","8.927e-01 ± 1.674e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","6.796e-01 ± 7.811e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","4.773e-01 ± 5.021e-16","3.297e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","5.551e-01 ± 8.927e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","5.971e-01 ± 0.000e+00","1.162e+00 ± 2.901e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","2.341e-01 ± 5.579e-16","8.689e+00 ± 1.428e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","⇔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","9.066e-01 ± 1.339e-15","9.641e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_CREB attaches to the CBC (till now)"," forming a circular mRNA_CREB"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_CREB with a 5'-cap"]
["// PABP joins Cap_mRNA_CREB at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_CREB","↔","Cap_mRNA_CREB_PABP","2.710e-01 ± 2.790e-16","1.328e-01 ± 1.953e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_CREB_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP","6.407e-01 ± 0.000e+00","2.251e+00 ± 3.124e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_CREB and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","6.019e-02 ± 5.579e-17","4.210e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","6.322e-01 ± 7.811e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","5.270e-01 ± 8.927e-16","6.842e+00 ± 9.819e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","2.686e-01 ± 4.463e-16","4.128e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","6.218e-01 ± 6.695e-16","2.866e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","7.754e-01 ± 1.116e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","8.537e-01 ± 8.927e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","1.196e-01 ± 1.116e-16","9.887e+00 ± 2.142e-14"," -- "]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","5.032e-02 ± 8.369e-17 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","7.039e-01 ± 1.339e-15","1.415e+00 ± 1.562e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","7.580e-01 ± 0.000e+00","7.131e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","⇔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","6.435e-01 ± 1.004e-15","7.776e+00 ± 1.250e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_ETS attaches to the CBC (till now)"," forming a circular mRNA_ETS"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_ETS with a 5'-cap"]
["// PABP joins Cap_mRNA_ETS at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_ETS","↔","Cap_mRNA_ETS_PABP","4.620e-01 ± 5.579e-16","2.815e+00 ± 1.339e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_ETS_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP","4.612e-01 ± 3.347e-16","1.835e-01 ± 1.116e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_ETS and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","9.771e-01 ± 2.232e-15","3.640e+00 ± 4.463e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","4.929e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","3.900e-01 ± 1.116e-16","8.859e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","2.722e-02 ± 5.230e-17","5.103e+00 ± 8.034e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","8.726e-01 ± 4.463e-16","9.930e+00 ± 2.499e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","3.172e-01 ± 1.674e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","8.364e-01 ± 1.562e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","8.007e-01 ± 1.004e-15","6.164e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","8.059e-01 ± 5.579e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","5.857e-01 ± 5.579e-16","3.583e+00 ± 3.124e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","3.717e-01 ± 3.905e-16","2.053e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","5.715e-01 ± 7.811e-16","9.647e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_BRN attaches to the CBC (till now)"," forming a circular mRNA_BRN"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_BRN with a 5'-cap"]
["// PABP joins Cap_mRNA_BRN at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_BRN","↔","Cap_mRNA_BRN_PABP","9.551e-01 ± 1.562e-15","5.493e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_BRN_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP","6.079e-01 ± 1.227e-15","3.203e+00 ± 4.463e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_BRN and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","2.518e-01 ± 5.021e-16","1.736e+00 ± 8.927e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","6.426e-01 ± 6.695e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","1.303e-01 ± 1.395e-16","9.526e+00 ± 1.250e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","7.461e-01 ± 0.000e+00","4.021e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","5.576e-01 ± 1.451e-15","7.393e+00 ± 8.034e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","8.942e-01 ± 1.227e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","4.130e-03 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","2.704e-01 ± 4.463e-16","2.146e-01 ± 8.369e-17"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","5.547e-01 ± 1.004e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","2.977e-01 ± 7.253e-16","5.412e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","1.464e-01 ± 0.000e+00","3.592e-01 ± 1.674e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","5.292e-01 ± 1.004e-15","2.359e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_IRF attaches to the CBC (till now)"," forming a circular mRNA_IRF"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_IRF with a 5'-cap"]
["// PABP joins Cap_mRNA_IRF at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_IRF","↔","Cap_mRNA_IRF_PABP","9.885e-01 ± 1.562e-15","9.187e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_IRF_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP","3.001e-01 ± 5.579e-16","6.826e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_IRF and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","8.270e-01 ± 1.116e-15","3.484e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","6.809e-01 ± 1.227e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","3.528e-01 ± 4.463e-16","4.650e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","9.735e-01 ± 0.000e+00","7.781e+00 ± 1.964e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","3.825e-03 ± 0.000e+00","6.135e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","7.725e-01 ± 8.927e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","1.194e-02 ± 1.744e-17 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","4.370e-01 ± 7.811e-16","6.635e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","2.753e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","8.553e-01 ± 4.463e-16","3.023e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","1.087e-01 ± 2.092e-16","2.360e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","8.098e-01 ± 1.227e-15","4.487e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_SRPK attaches to the CBC (till now)"," forming a circular mRNA_SRPK"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_SRPK with a 5'-cap"]
["// PABP joins Cap_mRNA_SRPK at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_SRPK","↔","Cap_mRNA_SRPK_PABP","4.044e-02 ± 7.671e-17","6.407e+00 ± 4.463e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_SRPK_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP","9.499e-01 ± 1.339e-15","1.623e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_SRPK and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","3.368e-01 ± 3.905e-16","4.523e-01 ± 6.137e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","4.530e-01 ± 5.579e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","2.588e-01 ± 2.790e-16","3.940e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","6.303e-01 ± 1.227e-15","1.520e+00 ± 3.124e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","4.078e-01 ± 3.905e-16","5.067e+00 ± 9.819e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","3.212e-02 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","2.952e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","2.506e-01 ± 2.790e-16","2.944e+00 ± 4.463e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","9.626e-01 ± 1.004e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","3.811e-01 ± 3.905e-16","8.460e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","8.926e-01 ± 6.695e-16","8.681e+00 ± 1.250e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","1.441e-01 ± 3.347e-16","7.291e+00 ± 9.819e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_pRb attaches to the CBC (till now)"," forming a circular mRNA_pRb"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_pRb with a 5'-cap"]
["// PABP joins Cap_mRNA_pRb at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_pRb","↔","Cap_mRNA_pRb_PABP","9.780e-01 ± 2.455e-15","3.920e+00 ± 8.480e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_pRb_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP","5.151e-01 ± 3.347e-16","3.982e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_pRb and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","8.507e-02 ± 4.184e-17","2.038e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","6.504e-01 ± 1.339e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","3.611e-01 ± 4.463e-16","8.112e-01 ± 1.116e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","8.379e-01 ± 1.227e-15","9.316e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","9.661e-01 ± 1.004e-15","1.168e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","5.447e-01 ± 1.116e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","1.744e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","1.171e-01 ± 1.953e-16","8.461e+00 ± 1.428e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","7.978e-01 ± 7.811e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","1.532e-01 ± 2.511e-16","6.320e+00 ± 8.034e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","2.167e-01 ± 2.232e-16","2.450e-01 ± 3.626e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","9.460e-01 ± 0.000e+00","4.405e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_RhoGDI attaches to the CBC (till now)"," forming a circular mRNA_RhoGDI"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_RhoGDI with a 5'-cap"]
["// PABP joins Cap_mRNA_RhoGDI at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_RhoGDI","↔","Cap_mRNA_RhoGDI_PABP","6.747e-01 ± 5.579e-16","3.320e+00 ± 7.587e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_RhoGDI_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP","5.387e-01 ± 1.339e-15","3.816e-01 ± 1.116e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_RhoGDI and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","1.961e-01 ± 3.068e-16","4.840e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","5.843e-01 ± 1.116e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","6.133e-01 ± 6.695e-16","1.609e+00 ± 2.901e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","1.529e-01 ± 8.369e-17","2.109e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","4.621e-02 ± 2.092e-17","7.220e+00 ± 8.034e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","5.174e-01 ± 1.004e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","2.938e-01 ± 6.695e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","5.445e-01 ± 4.463e-16","9.800e+00 ± 3.571e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","↔","eIF2_GTP+eIF2B","--","--","6.057e-01 ± 8.927e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","6.626e-01 ± 4.463e-16","2.133e-01 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","9.799e-01 ± 1.116e-15","3.958e+00 ± 6.695e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","3.035e-01 ± 5.021e-16","4.508e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_P47phox attaches to the CBC (till now)"," forming a circular mRNA_P47phox"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_P47phox with a 5'-cap"]
["// PABP joins Cap_mRNA_P47phox at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_P47phox","↔","Cap_mRNA_P47phox_PABP","2.638e-01 ± 4.463e-16","5.740e+00 ± 8.927e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_P47phox_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP","7.323e-01 ± 1.116e-16","3.409e+00 ± 1.339e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_P47phox and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","4.811e-01 ± 3.905e-16","2.717e-01 ± 5.021e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","3.648e-01 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","1.541e-01 ± 1.953e-16","3.407e+00 ± 4.910e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","5.975e-01 ± 5.579e-16","8.914e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","9.739e-01 ± 1.116e-16","1.722e-01 ± 2.790e-16"," -- "]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","3.646e-01 ± 4.463e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","3.750e-01 ± 4.463e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","9.681e-01 ± 1.451e-15","9.693e+00 ± 1.785e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","7.352e-01 ± 2.232e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","3.344e-02 ± 7.671e-17","2.302e+00 ± 4.017e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","1.812e-02 ± 0.000e+00","9.210e+00 ± 3.571e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","4.433e-01 ± 5.021e-16","3.961e+00 ± 9.373e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_CD45 attaches to the CBC (till now)"," forming a circular mRNA_CD45"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_CD45 with a 5'-cap"]
["// PABP joins Cap_mRNA_CD45 at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_CD45","↔","Cap_mRNA_CD45_PABP","4.449e-01 ± 5.579e-17","9.600e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_CD45_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP","2.073e-01 ± 5.579e-17","2.532e-01 ± 6.137e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_CD45 and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","8.141e-01 ± 4.463e-16","3.025e+00 ± 4.017e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","9.639e-01 ± 2.232e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","1.135e-01 ± 8.369e-17","2.071e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","1.197e-01 ± 1.953e-16","9.859e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","2.605e-01 ± 2.790e-16","5.586e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","9.186e-01 ± 1.451e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","5.155e-01 ± 1.004e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","9.562e-01 ± 1.116e-15","8.286e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","7.499e-01 ± 3.347e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","4.118e-01 ± 7.811e-16","1.644e+00 ± 2.678e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","8.149e-01 ± 1.451e-15","2.811e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","6.509e-01 ± 2.232e-16","8.902e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_EIF2AK attaches to the CBC (till now)"," forming a circular mRNA_EIF2AK"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_EIF2AK with a 5'-cap"]
["// PABP joins Cap_mRNA_EIF2AK at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_EIF2AK","↔","Cap_mRNA_EIF2AK_PABP","5.122e-01 ± 8.927e-16","2.736e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_EIF2AK_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP","7.102e-01 ± 1.116e-15","6.941e+00 ± 1.428e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_EIF2AK and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","5.911e-02 ± 1.395e-16","5.508e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","8.941e-01 ± 7.811e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","1.819e-01 ± 3.905e-16","4.772e+00 ± 3.571e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","3.724e-01 ± 6.695e-16","2.124e+00 ± 3.124e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","3.442e-01 ± 5.579e-16","6.061e+00 ± 4.463e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","2.422e-01 ± 2.511e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","5.121e-01 ± 3.347e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","2.440e-01 ± 3.905e-16","8.621e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","5.652e-01 ± 1.339e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","1.793e-01 ± 2.790e-16","9.598e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","7.096e-01 ± 7.811e-16","2.473e+00 ± 5.802e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","8.768e-01 ± 0.000e+00","8.786e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_SIIIp15 attaches to the CBC (till now)"," forming a circular mRNA_SIIIp15"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_SIIIp15 with a 5'-cap"]
["// PABP joins Cap_mRNA_SIIIp15 at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_SIIIp15","↔","Cap_mRNA_SIIIp15_PABP","2.375e-02 ± 6.276e-17","2.790e+00 ± 4.463e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_SIIIp15_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP","4.680e-01 ± 1.116e-15","4.032e+00 ± 4.463e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_SIIIp15 and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","8.424e-01 ± 1.116e-15","5.872e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","4.831e-01 ± 5.579e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","8.909e-01 ± 1.004e-15","3.617e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","9.471e-01 ± 1.897e-15","2.320e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","1.698e-01 ± 4.742e-16","4.089e+00 ± 8.927e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","5.532e-01 ± 1.116e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","9.412e-01 ± 2.009e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","2.954e-01 ± 4.463e-16","4.558e-01 ± 6.695e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","9.197e-01 ± 1.339e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","9.583e-02 ± 2.790e-17","3.028e+00 ± 4.910e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","3.957e-01 ± 2.232e-16","1.461e+00 ± 2.455e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","5.079e-01 ± 5.579e-16","5.875e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_AAF attaches to the CBC (till now)"," forming a circular mRNA_AAF"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_AAF with a 5'-cap"]
["// PABP joins Cap_mRNA_AAF at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_AAF","↔","Cap_mRNA_AAF_PABP","2.764e-01 ± 5.579e-17","2.226e+00 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_AAF_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP","4.974e-01 ± 5.579e-16","2.029e+00 ± 4.910e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_AAF and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","7.122e-01 ± 7.811e-16","9.747e+00 ± 1.785e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","9.740e-01 ± 7.811e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","8.036e-01 ± 7.811e-16","9.584e+00 ± 1.250e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","4.484e-01 ± 8.369e-16","1.373e+00 ± 2.009e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","1.814e-01 ± 2.232e-16","2.268e+00 ± 2.232e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","2.436e-02 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","9.743e-01 ± 2.009e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","3.419e-01 ± 5.579e-17","9.125e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","3.160e-01 ± 2.790e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","7.284e-01 ± 7.811e-16","8.543e+00 ± 1.964e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","7.516e-01 ± 1.116e-16","9.533e+00 ± 1.428e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","3.608e-02 ± 9.763e-17","7.662e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_Stat5b attaches to the CBC (till now)"," forming a circular mRNA_Stat5b"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_Stat5b with a 5'-cap"]
["// PABP joins Cap_mRNA_Stat5b at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_Stat5b","↔","Cap_mRNA_Stat5b_PABP","8.121e-03 ± 0.000e+00","6.832e+00 ± 1.160e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_Stat5b_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP","4.851e-01 ± 4.463e-16","7.247e+00 ± 6.249e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_Stat5b and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","4.797e-01 ± 7.253e-16","8.299e+00 ± 1.250e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","9.332e-01 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","6.662e-02 ± 0.000e+00","8.448e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","4.717e-02 ± 1.255e-16","4.609e-01 ± 7.811e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","5.517e-01 ± 5.579e-16","6.292e+00 ± 1.785e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","4.690e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","1.618e-01 ± 1.953e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","9.831e-02 ± 1.674e-16","8.599e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","8.195e-01 ± 1.785e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","7.696e-01 ± 2.232e-16","3.527e+00 ± 4.910e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","2.981e-01 ± 0.000e+00","7.778e+00 ± 1.785e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","6.036e-01 ± 3.347e-16","1.722e+00 ± 3.794e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_XRE attaches to the CBC (till now)"," forming a circular mRNA_XRE"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_XRE with a 5'-cap"]
["// PABP joins Cap_mRNA_XRE at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_XRE","↔","Cap_mRNA_XRE_PABP","9.930e-01 ± 2.343e-15","9.090e+00 ± 2.499e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_XRE_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP","5.941e-01 ± 1.339e-15","1.377e+00 ± 1.116e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_XRE and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","⇔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","7.828e-01 ± 6.695e-16","7.727e+00 ± 9.819e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","6.943e-01 ± 5.579e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","1.956e-02 ± 5.230e-17","2.855e+00 ± 4.463e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","3.982e-01 ± 1.060e-15","9.057e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","7.224e-01 ± 8.927e-16","8.657e+00 ± 1.785e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","1.748e-01 ± 8.369e-17 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","6.625e-01 ± 7.811e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","6.031e-01 ± 8.927e-16","4.433e-01 ± 7.811e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","3.498e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","1.029e-01 ± 1.674e-16","2.186e+00 ± 4.910e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","8.245e-01 ± 1.227e-15","7.473e+00 ± 1.250e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","6.558e-01 ± 1.116e-15","4.978e+00 ± 1.071e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_SAP attaches to the CBC (till now)"," forming a circular mRNA_SAP"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_SAP with a 5'-cap"]
["// PABP joins Cap_mRNA_SAP at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_SAP","↔","Cap_mRNA_SAP_PABP","4.480e-01 ± 6.695e-16","2.642e-01 ± 3.347e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_SAP_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP","8.005e-01 ± 4.463e-16","4.824e-01 ± 7.253e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_SAP and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","1.679e-01 ± 1.953e-16","7.822e+00 ± 7.141e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","8.207e-01 ± 6.695e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","8.140e-01 ± 2.232e-16","7.252e+00 ± 4.463e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","5.952e-02 ± 1.395e-16","8.648e+00 ± 1.607e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","5.803e-01 ± 0.000e+00","3.514e+00 ± 8.034e-15"," -- "]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","3.978e-01 ± 3.905e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","6.525e-01 ± 6.695e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","⇔","eIF2_GDP_eIF2B","8.842e-01 ± 1.227e-15","2.839e+00 ± 2.678e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","3.535e-01 ± 0.000e+00 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","7.198e-01 ± 1.116e-15","7.372e+00 ± 8.927e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","9.769e-01 ± 2.455e-15","5.578e+00 ± 5.356e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","1.823e-01 ± 2.790e-17","1.886e+00 ± 8.927e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// poly-A binding protein (PABP) at 3' end of mRNA_BLR1 attaches to the CBC (till now)"," forming a circular mRNA_BLR1"]
["// PABP formation and degradation"]
["// CBC is the final Cap-binding complex (now it should have PABP)  "]
["// CBC Joins mRNA_BLR1 with a 5'-cap"]
["// PABP joins Cap_mRNA_BLR1 at the 3' end (not depicted here)"," I am not modeling PABP and eIF4G interaction then."]
["PABP+Cap_mRNA_BLR1","↔","Cap_mRNA_BLR1_PABP","4.196e+01 ± 0.000e+00","5.880e-01 ± 1.562e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H+Cap_mRNA_BLR1_PABP","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP","6.181e+01 ± 1.285e-13","6.906e-01 ± 7.811e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//CBC_Cap_mRNA_BLR1 and 43S combine to form 48S"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP+eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","2.298e+01 ± 0.000e+00","6.991e-01 ± 6.695e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Scanning"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG","--","--","8.155e+01 ± 9.998e-14 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// Finding AUG triggers eIF2-GTP hydrolysis to eIF-GDP"," other factors except eIF5 and eIF5B can remain on 40S"]
["// eIF5 and eIF5B induce GTP hydrolysis and 60S sub-unit joining."]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5","2.395e+01 ± 1.785e-14","8.323e-01 ± 1.227e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5+eIF5B","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","9.993e+01 ± 1.428e-13","1.566e-01 ± 1.674e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5_eIF5B can also bind to 48S_Scan"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG+eIF5_eIF5B","⇔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","8.420e+01 ± 1.143e-13","5.590e+01 ± 8.569e-14"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GTP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","--","--","2.770e-01 ± 7.253e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF2_GDP departs from the complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_eIF2_GDP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B","→","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+eIF2_GDP","--","--","8.911e+01 ± 1.143e-13 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["//eIF2_GDP is converted to eIF2_GTP with the help of eIF2B"]
["eIF2_GDP+eIF2B","↔","eIF2_GDP_eIF2B","3.990e+01 ± 1.428e-14","3.535e-01 ± 2.790e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF2_GDP_eIF2B","→","eIF2_GTP+eIF2B","--","--","9.934e+01 ± 2.571e-13 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// 60S Formation and degradation"]
["// 60S binds with 48S_Scan and minus eIF2-GTP"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B+60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","8.429e+01 ± 1.143e-13","1.405e-01 ± 1.953e-16"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF5s Depart"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_eIF5_eIF5B_AUG_eIF5_eIF5B_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S+eIF5+eIF5B","8.512e+01 ± 9.998e-14","9.814e-01 ± 2.455e-15"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["// eIF3"," eIF1 and IF1A depart to give 80S Initiation complex with Cap binding complex"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_eIF3_eIF1_eIF1A_AUG_60S","↔","eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_AUG_60S+eIF3+eIF1+eIF1A","2.759e+01 ± 3.571e-14","5.192e-01 ± 0.000e+00"," -- ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
[]
[]
["// The 80S formed for proteins so far have to be converted to proteins. This requires elongation and termination step"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Oct1_PABP_met_tRNA_40S_AUG_60S","→","Oct1+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","5.675e-01 ± 5.579e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CREB_PABP_met_tRNA_40S_AUG_60S","→","CREB+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","5.407e-01 ± 2.232e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.051"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_ETS_PABP_met_tRNA_40S_AUG_60S","→","ETS+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","3.142e-01 ± 4.463e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341659 ","http://dx.doi.org/10.1016/j.gene.2004.02.052"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BRN_PABP_met_tRNA_40S_AUG_60S","→","BRN+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","8.294e-01 ± 1.116e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341660","http://dx.doi.org/10.1016/j.gene.2004.02.053"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_IRF_PABP_met_tRNA_40S_AUG_60S","→","IRF+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","6.054e-01 ± 1.116e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341661","http://dx.doi.org/10.1016/j.gene.2004.02.054"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SRPK_PABP_met_tRNA_40S_AUG_60S","→","SRPK+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","5.323e-01 ± 8.927e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341662","http://dx.doi.org/10.1016/j.gene.2004.02.055"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_pRb_PABP_met_tRNA_40S_AUG_60S","→","pRb+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","5.607e-01 ± 1.004e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341663","http://dx.doi.org/10.1016/j.gene.2004.02.056"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_RhoGDI_PABP_met_tRNA_40S_AUG_60S","→","RhoGDI+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","2.066e-01 ± 3.626e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341664","http://dx.doi.org/10.1016/j.gene.2004.02.057"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_P47phox_PABP_met_tRNA_40S_AUG_60S","→","P47phox+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","8.183e-01 ± 4.463e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341665","http://dx.doi.org/10.1016/j.gene.2004.02.058"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_CD45_PABP_met_tRNA_40S_AUG_60S","→","CD45+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","4.315e-01 ± 4.463e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341666","http://dx.doi.org/10.1016/j.gene.2004.02.059"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_EIF2AK_PABP_met_tRNA_40S_AUG_60S","→","EIF2AK+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","9.656e-01 ± 2.120e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341667","http://dx.doi.org/10.1016/j.gene.2004.02.060"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SIIIp15_PABP_met_tRNA_40S_AUG_60S","→","SIIIp15+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","4.738e-01 ± 2.790e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341668","http://dx.doi.org/10.1016/j.gene.2004.02.061"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_AAF_PABP_met_tRNA_40S_AUG_60S","→","AAF+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","8.613e-01 ± 6.695e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341669","http://dx.doi.org/10.1016/j.gene.2004.02.062"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_Stat5b_PABP_met_tRNA_40S_AUG_60S","→","Stat5b+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","1.825e-01 ± 2.790e-17 ","http://journals.cambridge.org/action/displayAbstract?aid=341670","http://dx.doi.org/10.1016/j.gene.2004.02.063"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_XRE_PABP_met_tRNA_40S_AUG_60S","→","XRE+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","6.759e-01 ± 1.116e-15 ","http://journals.cambridge.org/action/displayAbstract?aid=341671","http://dx.doi.org/10.1016/j.gene.2004.02.064"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_SAP_PABP_met_tRNA_40S_AUG_60S","→","SAP+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","4.465e-01 ± 5.021e-16 ","http://journals.cambridge.org/action/displayAbstract?aid=341672","http://dx.doi.org/10.1016/j.gene.2004.02.065"]
["eIF4A_eIF4G_eIF4E_eIF4B_eIF4H_Cap_mRNA_BLR1_PABP_met_tRNA_40S_AUG_60S","→","BLR1+eIF4A+eIF4G+eIF4E+eIF4B+eIF4H+PABP+met_tRNA+40S+60S","--","--","5.645e+01 ± 5.713e-14 ","http://journals.cambridge.org/action/displayAbstract?aid=341673","http://dx.doi.org/10.1016/j.gene.2004.02.066"]
["//  "]
["// ------- Transcription factor activation ----------"]
["//---PKC---"]
["//Reaction for the kinase PKC as found in networKIN"]
["CREB+PKCact","↔","CREB_PKCact","2.422e-01 ± 3.905e-16","8.632e+00 ± 8.927e-15"," -- ","http://networkin.info/search.php"]
["CREB_PKCact","→","CREB_p+PKCact","--","--","1.655e-01 ± 1.674e-16 ","http://networkin.info/search.php"]
["IRF+PKCact","↔","IRF_PKCact","8.843e-01 ± 1.562e-15","6.124e+00 ± 8.034e-15"," -- ","http://networkin.info/search.php"]
["IRF_PKCact","→","IRF_p+PKCact","--","--","9.907e-01 ± 2.009e-15 ","http://networkin.info/search.php"]
["pRb+PKCact","↔","pRb_PKCact","2.049e-01 ± 2.790e-17","1.391e-01 ± 0.000e+00"," -- ","http://networkin.info/search.php"]
["pRb_PKCact","→","pRb_p+PKCact","--","--","1.652e-01 ± 0.000e+00 ","http://networkin.info/search.php"]
["RhoGDI+PKCact","↔","RhoGDI_PKCact","9.742e-01 ± 1.339e-15","6.523e+00 ± 1.160e-14"," -- ","http://networkin.info/search.php"]
["RhoGDI_PKCact","→","RhoGDI_p+PKCact","--","--","8.622e-01 ± 3.347e-16 ","http://networkin.info/search.php"]
["P47phox+PKCact","↔","P47phox_PKCact","3.942e-01 ± 1.674e-16","2.149e+00 ± 3.124e-15"," -- ","http://networkin.info/search.php"]
["P47phox_PKCact","→","P47phox_p+PKCact","--","--","5.857e-01 ± 6.695e-16 ","http://networkin.info/search.php"]
["EIF2AK+PKCact","↔","EIF2AK_PKCact","7.817e-01 ± 1.227e-15","5.353e-01 ± 1.227e-15"," -- ","http://networkin.info/search.php"]
["EIF2AK_PKCact","→","CEIF2AK_p+PKCact","--","--","5.397e-01 ± 6.695e-16 ","http://networkin.info/search.php"]
["//---ERK---"]
["//Reactions for the kinase ERK as foud in networKIN"]
["Stat5b+ERK_pp","↔","Stat5b_ERK_pp","2.179e-01 ± 8.369e-17","1.170e+00 ± 1.785e-15"," -- ","http://networkin.info/search.php"]
["Stat5b_ERK_pp","→","Stat5b_p+ERK_pp","--","--","7.592e-01 ± 1.116e-15 ","http://networkin.info/search.php"]
["P47phox+ERK_pp","↔","P47phox_ERK_pp","6.675e-01 ± 7.811e-16","3.092e-02 ± 0.000e+00"," -- ","http://networkin.info/search.php"]
["P47phox_ERK_pp","→","P47phox_p+ERK_pp","--","--","8.765e-01 ± 1.451e-15 ","http://networkin.info/search.php"]
["EIF2AK+ERK_pp","↔","EIF2AK_ERK_pp","5.164e-01 ± 2.232e-16","9.439e+00 ± 1.785e-14"," -- ","http://networkin.info/search.php"]
["EIF2AK_ERK_pp","→","EIF2AK_p+ERK_pp","--","--","9.115e-01 ± 1.116e-15 ","http://networkin.info/search.php"]
["NFATc3+ERK_pp","↔","NFATc3_ERK_pp","5.861e+00 ± 1.160e-14","1.000e-01 ± 0.000e+00"," -- ","http://networkin.info/search.php"]
["NFATc3_ERK_pp","→","NFATc3_p+ERK_pp","--","--","7.301e+00 ± 1.696e-14 ","http://networkin.info/search.php"]
["//--Akt---"]
["//Reactions for the kinase AKT as found in networKIN"]
["SRPK+Aktact","↔","SRPK_Aktact","7.617e-01 ± 7.811e-16","1.768e+00 ± 6.695e-16"," -- ","http://networkin.info/search.php"]
["SRPK_Aktact","→","SPRK_p+Aktact","--","--","3.511e-01 ± 4.463e-16 ","http://networkin.info/search.php"]
["//--EGFR---"]
["//Reactions for the kinase EGFR as found in networKIN"]
["IRF+EGFR_EGF_2_p","↔","IRF_EGFR_EGF_2_p","1.808e-02 ± 4.882e-17","9.730e+00 ± 1.607e-14"," -- ","http://networkin.info/search.php"]
["IRF_EGFR_EGF_2_p","→","IRF_p+EGFR_EGF_2_p","--","--","5.758e-01 ± 8.927e-16 ","http://networkin.info/search.php"]
[]
["Oct1","↔","Oct1_p","3.050e-01 ± 5.021e-16","5.505e+00 ± 3.571e-15"," -- ","http://networkin.info/search.php"]
["BRN","↔","BRN_p","3.515e-01 ± 5.579e-17","5.263e+00 ± 8.034e-15"," -- ","http://networkin.info/search.php"]
["ASSUMED PHOSPHATASES"]
["CREB_p+CREBphos","↔","CREB_p_CREBphos","8.455e-01 ± 2.232e-16","9.728e+00 ± 3.571e-15"," -- "]
["CREB_p_CREBphos","→","CREB+CREBphos","--","--","5.524e-01 ± 5.579e-16 "]
["IRF_p+IRFphos","↔","IRF_p_IRFphos","4.274e-02 ± 8.369e-17","1.759e+00 ± 2.455e-15"," -- "]
["IRF_p_IRFphos","→","IRF+IRFphos","--","--","3.132e-01 ± 2.790e-16 "]
["pRb_p+pRbphos","↔","pRb_p_pRbphos","6.792e-01 ± 5.579e-16","8.260e+00 ± 1.071e-14"," -- "]
["pRb_p_CREBphos","→","pRb+pRbphos","--","--","7.375e-01 ± 4.463e-16 "]
["RhoGDI_p+RhoGDIphos","↔","RhoGDI_p_RhoGDIphos","3.985e-01 ± 9.484e-16","7.101e-01 ± 1.116e-16"," -- "]
["RhoGDI_p_RhoGDIphos","→","RhoGDI+RhoGDIphos","--","--","9.050e-01 ± 8.927e-16 "]
["P47phox_p+P47phoxphos","↔","P47phox_p_P47phoxphos","1.872e-01 ± 3.068e-16","6.436e+00 ± 1.071e-14"," -- "]
["P47phox_p_P47phoxphos","→","P47phox+P47phoxphos","--","--","7.082e-01 ± 6.695e-16 "]
["ETS_p+ETSphos","↔","ETS_p_ETSphos","7.539e-01 ± 7.811e-16","8.652e+00 ± 0.000e+00"," -- "]
["ETS_p_ETSphos","→","ETS+ETSphos","--","--","2.722e-02 ± 6.974e-17 "]
["Stat5b_p+Stat5bphos","↔","Stat5b_p_Stat5bphos","8.217e-01 ± 1.116e-15","1.389e+00 ± 2.232e-16"," -- "]
["Stat5b_p_Stat5bphos","→","Stat5b+Stat5bphos","--","--","3.993e-01 ± 5.579e-17 "]
["EIF2AK_p+EIF2AKphos","↔","EIF2AK_p_EIF2AKphos","9.615e-01 ± 6.695e-16","2.312e+00 ± 2.678e-15"," -- "]
["EIF2AK_p_EIF2AKphos","→","EIF2AK+EIF2AKphos","--","--","9.896e-01 ± 2.455e-15 "]
["SRPK_p+SRPKphos","↔","SRPK_p_SRPKphos","7.945e-01 ± 6.695e-16","1.950e+00 ± 4.463e-16"," -- "]
["SRPK_p_SRPKphos","→","SRPK+SRPKphos","--","--","6.565e-01 ± 8.927e-16 "]
["NFATc3","↔","NFATc3_p","1.000e-02 ± 6.974e-18","3.433e+00 ± 6.695e-15"," -- "]
[]
[]
[]
[]
["Species",null,"Initial condition (A.U.)","Std. Dev"]
["RAR",null,100.155767705113,49.1384272788814]
["RXR",null,143.664587042357,165.096103828958]
["EGFR",null,152.067121275888,84.9741223582615]
["Grb2",null,88.9759452490637,79.9135524832227]
["Sos",null,164.414782108242,129.851230879889]
["Ras_GDP",null,98.8335793295564,39.2628687902532]
["Shc",null,310.270658408552,489.483060972731]
["PLCg",null,76.2062777339322,65.0351590483865]
["PKC",null,61.206140707602,52.285797127375]
["Raf",null,31.2975922096902,16.9460732903425]
["GAP",null,138.148956308274,118.351919803628]
["Pase1",null,230.641783510746,405.784441655989]
["MEK",null,210.0861740222,100.012971118531]
["ERK",null,172.924109836284,148.086020153578]
["Pase2",null,327.113883455261,251.428725612328]
["Pase3",null,266.009214363011,532.162691442398]
["SosPase",null,84.0798497477428,65.2106289415989]
["cPLA2",null,86.0088730229903,45.0021261941006]
["Prot",null,102.039473638243,134.586394341182]
["ETS",null,356.449261832637,431.289086228366]
["Pase5",null,62.2087285901756,44.2038462229069]
["AP1",null,129.063967385021,280.674138305832]
["Pase6",null,285.972686847911,175.107226608097]
["g_BLR1",null,130.130548464037,100.175724644803]
["oct_1",null,84.9852353664249,65.2172061315873]
["NFATc3",null,86.2810737954934,54.301891539207]
["CREB",null,82.1131269601078,59.4207859029568]
["g_CycD",null,99.9079190294311,88.8840160601834]
["RNAp",null,135.53354601145,76.0666187044369]
["Cdk4",null,207.374330985488,172.08630583546]
["Cdk6",null,53.7461494512007,30.9821873216657]
["p15",null,204.038785414173,142.415391443986]
["p16",null,195.1035657938,219.910002001616]
["p17",null,437.077006857853,730.77999140205]
["p18",null,160.052570944244,119.235166443054]
["p19",null,45.5358478652654,25.2057645741445]
["p21",null,191.088227512831,123.330945335271]
["p27",null,639.75742530306,975.451361221252]
["p57",null,66.3069900631557,37.0499027289986]
["E2F",null,114.203885588917,39.4634451080484]
["g_CycE",null,114.388464855821,79.7504829499357]
["CycE",null,130.360311835653,113.376959540973]
["Cdk2",null,291.421604648364,154.153673921602]
["CDC25A",null,487.055455359435,1099.56077907039]
["g_E2F",null,71.8936290007549,38.9858781935737]
["ATPx",null,49.9223111527667,32.0308568042988]
["Gq_GDP",null,183.116008741443,258.112765246599]
["PLCb",null,106.173575162536,25.6803267527236]
["CAi",null,121.567983904482,100.819171273855]
["IP3R",null,275.837293577077,208.326094816833]
["PI3K",null,58.9478822086417,20.127868615416]
["PtdIns2",null,202.682860498052,105.634910135257]
["PTEN",null,58.4404464339528,37.0879920104004]
["Akt",null,423.502444685263,888.51865892629]
["Pdk1",null,475.369016773794,550.850953968127]
["TOR",null,106.91251901238,64.5124852507305]
["4E_BP1",null,388.579259187678,377.369119836776]
["eIF4E",null,87.4784474498964,53.9260213824361]
["g_Oct1",null,171.775716733154,93.3632211203324]
["g_CREB",null,219.552371325645,161.496602277762]
["g_ETS",null,136.86949960584,84.6920700187198]
["g_BRN",null,94.6779006145923,81.1223394409278]
["g_IRF",null,116.544573522175,112.688052594526]
["g_SRPK",null,205.469159086238,322.585550268596]
["g_RB",null,89.2581908769827,66.6945623239631]
["g_RhoGDI",null,141.695525782316,78.0491671870333]
["g_P47phox",null,82.6777086611578,50.3465031606485]
["g_CD45",null,118.04323391277,95.4924765621191]
["g_EIF2AK",null,138.610132008792,298.474446644225]
["g_SIIIp15",null,175.561979661172,95.203139767112]
["g_AAF",null,584.625144382548,496.879469723428]
["g_Stat5b",null,115.664962877003,55.6157874336809]
["g_XRE",null,59.6582440467561,27.7679931896526]
["g_SAP",null,177.384159969995,177.087883449306]
["40S",null,246.92985637014,180.382207457361]
["60S",null,848.26321593396,1588.65703405755]
["CREBphos",null,167.128361341194,79.0586124942753]
["IRFphos",null,188.099567809856,121.518662531561]
["RBphos",null,180.878208025906,140.820329798686]
["RhoGDIphos",null,50.3787677049405,33.1336994275477]
["P47phoxphos",null,76.4985798241298,76.6182754083713]
["ETSphos",null,150.707698424862,149.870928009654]
["Stat5bphos",null,47.4057837411251,23.1493804377981]
["EIF2AKphos",null,113.803851414848,98.4899590367103]
["SRPKphos",null,123.102116620341,113.412481650815]
["met_tRNA",null,68.7590103715007,36.3837343508821]
["p70",null,112.532854204784,62.403975473445]
["eIF2",null,163.1758553756,138.991621552377]
["PABP",null,2308.0691038419,5518.73398218605]
["eIF4A",null,257.721361822345,238.395689229579]
["eIF4B",null,110.456417433389,48.0313031696683]
["eIF4G",null,148.10073105871,136.165271847954]
["eIF4H",null,264.097659890871,309.40629988408]
["eIF2B",null,139.313469245178,248.7131630683]
["eIF1",null,64.2767957963228,30.3726639496775]
["eIF1A",null,218.857064698407,197.238657056869]
["eIF3",null,67.0452649944995,59.1359135783459]
["eIF5",null,62.4815593455657,23.4404771028733]
["eIF5B",null,78.0218995673193,43.9744937126466]
["GAB",null,129.976644560877,36.6768962870183]
["GDP",null,278.917000021372,182.371491365984]
["GTP",null,175.499338842496,162.454999340255]
["Ras",null,59.3520163538462,31.6385127180347]
["TSC1",null,87.1006790739407,29.2487620066255]
["TSC2",null,991.696193449699,2053.46591168384]
["Rheb",null,122.641299938314,117.29768236126]