% A # Watanabe 1995
Wee1 ATP <--> Wee1-aT
% B
Cdk4 Wee1-aT <--> Cdk4-Wee1-aT
% B
Cdk4-Wee1-aT --> Cdk4(T14P) Wee1 ADP
% A # Natural hydrolysis
Cdk4(T14P) --> Cdk4 P
% B
Cdk6 Wee1-aT <--> Cdk6-Wee1-aT
% B
Cdk6-Wee1-aT --> Cdk6(T14P) Wee1 ADP
% B
Cdk6(Y15P) Wee1-aT <--> Cdk6(Y15P)-Wee1-aT
% B
Cdk6(Y15P)-Wee1-aT --> Cdk6(T14PY15P) Wee1 ADP
% B
Cdk6(T172P) Wee1-aT <--> Cdk6(T172P)-Wee1-aT
% B
Cdk6(T172P)-Wee1-aT --> Cdk6(T14PT172P) Wee1 ADP
% B
Cdk6(Y15PT172P) Wee1-aT <--> Cdk6(Y15PT172P)-Wee1-aT
% B
Cdk6(Y15PT172P)-Wee1-aT --> Cdk6(T14PY15PT172P) Wee1 ADP
% A # Natural hydrolysis
Cdk6(T14PY15P) --> Cdk6(Y15P) P
% A # Natural hydrolysis
Cdk6(T14PT172P) --> Cdk6(T172P) P
% A # Natural hydrolysis
Cdk6(T14PY15PT172P) --> Cdk6(Y15PT172P) P
% A # Natural hydrolysis
Cdk6(T14P) --> Cdk6 P
% B
Mik1 ATP <--> Mik1-aT
% B
Cdk4 Mik1-aT <--> Cdk4-Mik1-aT
% B
Cdk4-Mik1-aT --> Cdk4(T14P) Mik1 ADP
% B
Cdk6 Mik1-aT <--> Cdk6-Mik1-aT
% B
Cdk6-Mik1-aT --> Cdk6(T14P) Mik1 ADP
% B
Cdk6(Y15P) Mik1-aT <--> Cdk6(Y15P)-Mik1-aT
% B
Cdk6(Y15P)-Mik1-aT --> Cdk6(T14PY15P) Mik1 ADP
% B
Cdk6(T172P) Mik1-aT <--> Cdk6(T172P)-Mik1-aT
% B
Cdk6(T172P)-Mik1-aT --> Cdk6(T14PT172P) Mik1 ADP
% B
Cdk6(Y15PT172P) Mik1-aT <--> Cdk6(Y15PT172P)-Mik1-aT
% B
Cdk6(Y15PT172P)-Mik1-aT --> Cdk6(T14PY15PT172P) Mik1 ADP
% B
Myt1 ATP <--> Myt1-aT
% B
Cdk6 Myt1-aT <--> Cdk6-Myt1-aT
% B
Cdk6-Myt1-aT --> Cdk6(T14P) Myt1 ADP
% B
Cdk6-Myt1-aT --> Cdk6(Y15P) Myt1 ADP
% A # Natural hydrolysis
Cdk6(Y15P) --> Cdk6 P
% B
Cdk6(T14P) Myt1-aT <--> Cdk6(T14P)-Myt1-aT
% B
Cdk6(T14P)-Myt1-aT --> Cdk6(T14PY15P) Myt1 ADP
% B
Cdk6(Y15P) Myt1-aT <--> Cdk6(Y15P)-Myt1-aT
% B
Cdk6(Y15P)-Myt1-aT --> Cdk6(T14PY15P) Myt1 ADP
% B
Cdk6(T172P) Myt1-aT <--> Cdk6(T172P)-Myt1-aT
% B
Cdk6(T172P)-Myt1-aT --> Cdk6(Y15PT172P) Myt1 ADP
% B
Cdk6(T172P)-Myt1-aT --> Cdk6(T14PT172P) Myt1 ADP
% B
Cdk6(T14PT172P) Myt1-aT <--> Cdk6(T14PT172P)-Myt1-aT
% B
Cdk6(T14PT172P)-Myt1-aT --> Cdk6(T14PY15PT172P) Myt1 ADP
% B
Cdk6(Y15PT172P) Myt1-aT <--> Cdk6(Y15PT172P)-Myt1-aT
% B
Cdk6(Y15PT172P)-Myt1-aT --> Cdk6(T14PY15PT172P) Myt1 ADP
% A # Natural hydrolysis
Cdk6(Y15PT172P) --> Cdk6(Y15P) P
% A # Natural hydrolysis
Cdk6(T14PY1172P) --> Cdk6(T14P) P
% A # Natural hydrolysis
Cdk6(T14PY15P) --> Cdk6(T14P) P
% A # Fisher R.P. 1994, 
CycH-Cdk7 ATP <--> CycH-Cdk7(P)-aT
% A #  
Cdk4 CycH-Cdk7-aT <--> Cdk4-CycH-Cdk7-aT
% A #  
Cdk4-CycH-Cdk7-aT --> Cdk4(T172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk4(T172P) --> Cdk4 P
% A #  Poterszman, 1997
Cdk4(T14P) CycH-Cdk7-aT <--> Cdk4(T14P)-CycH-Cdk7-aT
% A #  Poterszman, 1997
Cdk4(T14P)-CycH-Cdk7-aT --> Cdk4(T14PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk4(T14PT172P) --> Cdk4(T14P) P
% A # Natural hydrolysis
Cdk4(T14PT172P) --> Cdk4(T172P) P
% A #  
Cdk4(Y15P) CycH-Cdk7-aT <--> Cdk4(Y15P)-CycH-Cdk7-aT
% A #  
Cdk4(Y15P)-CycH-Cdk7-aT --> Cdk4(Y15PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk4(Y15PT172P) --> Cdk4(Y15P) P
% A # Natural hydrolysis
Cdk4(Y15PT172P) --> Cdk4(T172P) P
% A # Natural hydrolysis
Cdk4(Y15P) --> Cdk4 P
% A #  
Cdk4(T14PY15P) CycH-Cdk7-aT <--> Cdk4(T14PY15P)-CycH-Cdk7-aT
% A #  
Cdk4(T14PY15P)-CycH-Cdk7-aT --> Cdk4(T14PY15PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk4(T14PY15PT172P) --> Cdk4(T14PY15P) P
% A # Natural hydrolysis
Cdk4(T14PY15PT172P) --> Cdk4(T14PT172P) P
% A # Natural hydrolysis
Cdk4(T14PY15PT172P) --> Cdk4(Y15PT172P) P
% A 
Cdk6 CycH-Cdk7-aT <--> Cdk6-CycH-Cdk7-aT
% A #  
Cdk6-CycH-Cdk7-aT --> Cdk6(T172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk6(T172P) --> Cdk6 P
% A 
Cdk6(T14P) CycH-Cdk7-aT <--> Cdk6(T14P)-CycH-Cdk7-aT
% A 
Cdk6(T14P)-CycH-Cdk7-aT --> Cdk6(T14PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk6(T14PT172P) --> Cdk6(T14P) P
% A #  
Cdk6(Y15P) CycH-Cdk7-aT <--> Cdk6(Y15P)-CycH-Cdk7-aT
% A #  
Cdk6(Y15P)-CycH-Cdk7-aT --> Cdk6(Y15PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk6(Y15PT172P) --> Cdk6(T172P) P
% A #  
Cdk6(T14PY15P) CycH-Cdk7-aT <--> Cdk6(T14PY15P)-CycH-Cdk7-aT
% A #  
Cdk6(T14PY15P)-CycH-Cdk7-aT --> Cdk6(T14PY15PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk6(T14PY15PT172P) --> Cdk6(T14PY15P) P
% A # Natural hydrolysis
Cdk6(T14PY15PT172P) --> Cdk6(T14PT172P) P
% A
CycD Cdk4 <--> CycD-Cdk4
% A
CycD Cdk6 <--> CycD-Cdk6
% A #  Serrano M. 1993
CycD Cdk4(T14P) <--> CycD-Cdk4(T14P)
% A #  Russo A.A. 1998
CycD Cdk6(T14P) <--> CycD-Cdk6(T14P)
% A #  Serrano M. 1993
CycD Cdk4(Y15P) <--> CycD-Cdk4(Y15P)
% A #  Russo A.A. 1998
CycD Cdk6(Y15P) <--> CycD-Cdk6(Y15P)
% A #  Serrano M. 1993
CycD Cdk4(T14PY15P) <--> CycD-Cdk4(T14PY15P)
% A #  Russo A.A. 1998
CycD Cdk6(T14PY15P) <--> CycD-Cdk6(T14PY15P)
% A #  Russo A.A. 1998
CycD Cdk4(T172P) <--> CycD-Cdk4(T172P)
% A #  Russo A.A. 1998
CycD Cdk6(T172P) <--> CycD-Cdk6(T172P)
% A #  Serrano M. 1993
CycD Cdk4(T14PT172P) <--> CycD-Cdk4(T14PT172P)
% A #  Russo A.A. 1998
CycD Cdk6(T14PT172P) <--> CycD-Cdk6(T14PT172P)
% A #  Serrano M. 1993
CycD Cdk4(Y15PT172P) <--> CycD-Cdk4(Y15PT172P)
% A #  Russo A.A. 1998
CycD Cdk6(Y15PT172P) <--> CycD-Cdk6(Y15PT172P)
% A #  Serrano M. 1993
CycD Cdk4(T14PY15PT172P) <--> CycD-Cdk4(T14PY15PT172P)
% A #  Russo A.A. 1998
CycD Cdk6(T14PY15PT172P) <--> CycD-Cdk6(T14PY15PT172P)
% B
CycD-Cdk6 Myt1-aT <--> CycD-Cdk6-Myt1-aT
% B
CycD-Cdk6-Myt1-aT --> CycD-Cdk6(T14P) Myt1 ADP
% A # Natural hydrolysis
CycD-Cdk6(T14P) --> CycD-Cdk6 P
% B
CycD-Cdk6-Myt1-aT --> CycD-Cdk6(Y15P) Myt1 ADP
% A # Natural hydrolysis
CycD-Cdk6(Y15P) --> CycD-Cdk6 P
% B
CycD-Cdk6(T14P) Myt1-aT <--> CycD-Cdk6(T14P)-Myt1-aT
% B
CycD-Cdk6(T14P)-Myt1-aT --> CycD-Cdk6(T14PY15P) Myt1 ADP
% B
CycD-Cdk6(Y15P) Myt1-aT <--> CycD-Cdk6(Y15P)-Myt1-aT
% B
CycD-Cdk6(Y15P)-Myt1-aT <--> CycD-Cdk6(T14PY15P) Myt1 ADP
% A # Natural hydrolysis
CycD-Cdk6(T14PY15P) --> CycD-Cdk6(T14P) P
% A # Natural hydrolysis
CycD-Cdk6(T14PY15P) --> CycD-Cdk6(Y15P) P
% A
CycD-Cdk4 CycH-Cdk7-aT <--> CycD-Cdk4-CycH-Cdk7-aT
% A
CycD-Cdk4-CycH-Cdk7-aT --> CycD-Cdk4(T172P) CycH-Cdk7 ADP
% A
CycD-Cdk6 CycH-Cdk7-aT <--> CycD-Cdk6-CycH-Cdk7-aT
% A
CycD-Cdk6-CycH-Cdk7-aT --> CycD-Cdk6(T172P) CycH-Cdk7 ADP
% A
CycD-Cdk4(T14P) CycH-Cdk7-aT <--> CycD-Cdk4(T14P)-CycH-Cdk7-aT
% A
CycD-Cdk4(T14P)-CycH-Cdk7-aT --> CycD-Cdk4(T14PT172P) CycH-Cdk7 ADP
% A
CycD-Cdk6(T14P) CycH-Cdk7-aT <--> CycD-Cdk6(T14P)-CycH-Cdk7-aT
% A
CycD-Cdk6(T14P)-CycH-Cdk7-aT --> CycD-Cdk6(T14PT172P) CycH-Cdk7 ADP
% A
CycD-Cdk4(Y15P) CycH-Cdk7-aT <--> CycD-Cdk4(Y15P)-CycH-Cdk7-aT
% A
CycD-Cdk4(Y15P)-CycH-Cdk7-aT --> CycD-Cdk4(Y15PT172P) CycH-Cdk7 ADP
% A
CycD-Cdk6(Y15P) CycH-Cdk7-aT <--> CycD-Cdk6(Y15P)-CycH-Cdk7-aT
% A
CycD-Cdk6(Y15P)-CycH-Cdk7-aT --> CycD-Cdk6(Y15PT172P) CycH-Cdk7 ADP
% A
CycD-Cdk4(T14PY15P) CycH-Cdk7-aT <--> CycD-Cdk4(T14PY15P)-CycH-Cdk7-aT
% A
CycD-Cdk4(T14PY15P)-CycH-Cdk7-aT --> CycD-Cdk4(T14PY15PT172P) CycH-Cdk7 ADP
% A
CycD-Cdk6(T14PY15P) CycH-Cdk7-aT <--> CycD-Cdk6(T14PY15P)-CycH-Cdk7-aT
% A
CycD-Cdk6(T14PY15P)-CycH-Cdk7-aT --> CycD-Cdk6(T14PY15PT172P) CycH-Cdk7 ADP
% A # Natural hydrolysis
CycD-Cdk4(T14PY15PT172P) --> CycD-Cdk4(T14PY15P) P
% A # Natural hydrolysis
CycD-Cdk4(T14PY15PT172P) --> CycD-Cdk4(T14PT172P) P
% A # Natural hydrolysis
CycD-Cdk4(T14PY15PT172P) --> CycD-Cdk4(Y15PT172P) P
% A # Natural hydrolysis
CycD-Cdk6(T14PY15PT172P) --> CycD-Cdk6(T14PY15P) P
% A # Natural hydrolysis
CycD-Cdk6(T14PY15PT172P) --> CycD-Cdk6(T14PT172P) P
% A # Natural hydrolysis
CycD-Cdk6(T14PY15PT172P) --> CycD-Cdk6(Y15PT172P) P
% A
CycD-Cdk4(T14P) Cdc25A <--> CycD-Cdk4(T14P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk4(T14P)-Cdc25A --> CycD-Cdk4 Cdc25A P
% A
CycD-Cdk6(T14P) Cdc25A <--> CycD-Cdk6(T14P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk6(T14P)-Cdc25A --> CycD-Cdk6 Cdc25A P
% A
CycD-Cdk4(Y15P) Cdc25A <--> CycD-Cdk4(Y15P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk4(Y15P)-Cdc25A --> CycD-Cdk4 Cdc25A P
% A
CycD-Cdk6(Y15P) Cdc25A <--> CycD-Cdk6(Y15P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk6(Y15P)-Cdc25A --> CycD-Cdk6 Cdc25A P
% A
CycD-Cdk4(T14PY15P) Cdc25A <--> CycD-Cdk4(T14PY15P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk4(T14PY15P)-Cdc25A --> CycD-Cdk4(T14P) Cdc25A P
% A # Natural hydrolysis
CycD-Cdk4(T14PY15P)-Cdc25A --> CycD-Cdk4(Y15P) Cdc25A P
% A
CycD-Cdk6(T14PY15P) Cdc25A <--> CycD-Cdk6(T14PY15P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk6(T14PY15P)-Cdc25A --> CycD-Cdk6(T14P) Cdc25A P
% A # Natural hydrolysis
CycD-Cdk6(T14PY15P)-Cdc25A --> CycD-Cdk6(Y15P) Cdc25A P
% A
CycD-Cdk4(T14PT172P) Cdc25A <--> CycD-Cdk4(T14PT172P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk4(T14PT172P)-Cdc25A --> CycD-Cdk4(T172P) Cdc25A P
% A
CycD-Cdk6(T14PT172P) Cdc25A <--> CycD-Cdk6(T14PT172P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk6(T14PT172P)-Cdc25A --> CycD-Cdk6(T172P) Cdc25A P
% A
CycD-Cdk4(Y15PT172P) Cdc25A <--> CycD-Cdk4(Y15PT172P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk4(Y15PT172P)-Cdc25A --> CycD-Cdk4(T172P) Cdc25A P
% A
CycD-Cdk6(Y15PT172P) Cdc25A <--> CycD-Cdk6(Y15PT172P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk6(Y15PT172P)-Cdc25A --> CycD-Cdk6(T172P) Cdc25A P
% A
CycD-Cdk4(T14PY15PT172P) Cdc25A <--> CycD-Cdk4(T14PY15PT172P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk4(T14PY15PT172P)-Cdc25A --> CycD-Cdk4(T14PT172P) Cdc25A P
% A # Natural hydrolysis
CycD-Cdk4(T14PY15PT172P)-Cdc25A --> CycD-Cdk4(Y15PT172P) Cdc25A P
% A
CycD-Cdk6(T14PY15PT172P) Cdc25A <--> CycD-Cdk6(T14PY15PT172P)-Cdc25A
% A # Natural hydrolysis
CycD-Cdk6(T14PY15PT172P)-Cdc25A --> CycD-Cdk6(T14PT172P) Cdc25A P
% A # Natural hydrolysis
CycD-Cdk6(T14PY15PT172P)-Cdc25A --> CycD-Cdk6(Y15PT172P) Cdc25A P
% A
CycD-Cdk4(T172P) KAP <--> CycD-Cdk4(T172P)-KAP
% A # Natural hydrolysis
CycD-Cdk4(T172P)-KAP --> CycD-Cdk4 KAP P
% A
CycD-Cdk6(T172P) KAP <--> CycD-Cdk6(T172P)-KAP
% A # Natural hydrolysis
CycD-Cdk6(T172P)-KAP --> CycD-Cdk6 KAP P
% A
CycD-Cdk4(T14PT172P) KAP <--> CycD-Cdk4(T14PT172P)-KAP
% A # Natural hydrolysis
CycD-Cdk4(T14PT172P)-KAP --> CycD-Cdk4(T14P) KAP P
% A
CycD-Cdk6(T14PT172P) KAP <--> CycD-Cdk6(T14PT172P)-KAP
% A # Natural hydrolysis
CycD-Cdk6(T14PT172P)-KAP --> CycD-Cdk6(T14P) KAP P
% A
CycD-Cdk4(Y15PT172P) KAP <--> CycD-Cdk4(Y15PT172P)-KAP
% A # Natural hydrolysis
CycD-Cdk4(Y15PT172P)-KAP --> CycD-Cdk4(Y15P) KAP P
% A
CycD-Cdk6(Y15PT172P) KAP <--> CycD-Cdk6(Y15PT172P)-KAP
% A # Natural hydrolysis
CycD-Cdk6(Y15PT172P)-KAP --> CycD-Cdk6(Y15P) Cdc25A P
% A
CycD-Cdk4(T14PY15PT172P) KAP <--> CycD-Cdk4(T14PY15PT172P)-KAP
% A # Natural hydrolysis
CycD-Cdk4(T14PY15PT172P)-KAP --> CycD-Cdk4(T14PY15P) KAP P
% A
CycD-Cdk6(T14PY15PT172P) KAP <--> CycD-Cdk6(T14PY15PT172P)-KAP
% A # Natural hydrolysis
CycD-Cdk6(T14PY15PT172P)-KAP --> CycD-Cdk6(T14PY15P) KAP P
% A
GSKn ATP <--> GSKn-aT
% A
CycD-Cdk4(T172P) GSKn-aT <--> CycD-Cdk4(T172P)-GSKn-aT
% A
CycD-Cdk4(T172P)-GSKn-aT --> CycD(P) Cdk4(T172P) GSKn ADP
% A
CycD-Cdk6(T172P) GSKn-aT <--> CycD-Cdk6(T172P)-GSKn-aT
% A
CycD-Cdk6(T172P)-GSKn-aT --> CycD(P) Cdk6(T172P) GSKn ADP
% A # Natural hydrolysis
CycD(P) --> CycD P
% A
Cdh1-Apcs nUb <--> Cdh1-Apcs-nUb
% A
SCF nUb <--> SCF-nUb
% A
CycD(P) Cdh1-Apcs-nUb <--> CycD{P(nUb)} Cdh1-Apcs
% A
CycD(P) SCF-nUb <--> CycD{P(nUb)} SCF
% A
CycD{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A 
CycD-Cdk4(T172P) ATP <--> CycD-Cdk4(T172P)-aT
% A 
CycD-Cdk4(T172P)-aT Rb-E2F <--> CycD-Cdk4(T172P)-aT-Rb-E2F
% A 
CycD-Cdk4(T172P)-aT-Rb-E2F --> CycD-Cdk4(T172P) Rb(S780P) E2F ADP
% A
CycD-Cdk6(T172P) ATP <--> CycD-Cdk6(T172P)-aT
% A
CycD-Cdk6(T172P)-aT Cdc6 <--> CycD-Cdk6(T172P)-aT-Cdc6
% A
CycD-Cdk6(T172P)-aT-Cdc6 --> CycD-Cdk6(T172P) ADP Cdc6(S/TP)
% A
ATM ATP <--> ATM-aT
% A
ATM-aT P53-MDM2 <--> ATM-aT-P53-MDM2
% A
ATM-aT-P53-MDM2 --> ATM ADP P53(P) MDM2
% A
ATM-aT P53(P) <--> ATM-aT-P53(P)
% A
ATM-aT-P53(P) --> ATM ADP P53(PP)
% A
P53(PP) P53(PP) P53(PP) P53(PP) <--> 4P53
% A
p21(g) 4P53 --> p21(r) 4P53
% A
p21(r) --> P21
% A # Natural hydrolysis
P53(PP) --> P53(P) P
% A # Natural hydrolysis
P53(P) --> P53 P
% A # Booher R.N.,1997
Cdk2 Wee1-aT <--> Cdk2-Wee1-aT
% A # Booher R.N.,1997
Cdk2-Wee1-aT --> Cdk2(T14P) Wee1 ADP
% A # Booher R.N.,1997
Cdk2(Y15P) Wee1-aT <--> Cdk2(Y15P)-Wee1-aT
% A # Booher R.N.,1997
Cdk2(Y15P)-Wee1-aT --> Cdk2(T14PY15P) Wee1 ADP
% A # Booher R.N.,1997
Cdk2(T160P) Wee1-aT <--> Cdk2(T160P)-Wee1-aT
% A # Booher R.N.,1997
Cdk2(T160P)-Wee1-aT --> Cdk2(T14PT160P) Wee1 ADP
% A # Booher R.N.,1997
Cdk2(Y15PT160P) Wee1-aT <--> Cdk2(Y15PT160P)-Wee1-aT
% A # Booher R.N.,1997
Cdk2(Y15PT160P)-Wee1-aT --> Cdk2(T14PY15PT160P) Wee1 ADP
% A # Natural hydrolysis
Cdk2(T14P) --> Cdk2 P
% A # Natural hydrolysis
Cdk2(T14PY15P) --> Cdk2(Y15P) P
% A # Natural hydrolysis
Cdk2(T14PY15P) --> Cdk2(T14P) P
% A
Cdk2 Mik1-aT <--> Cdk2-Mik1-aT
% A
Cdk2-Mik1-aT --> Cdk2(T14P) Mik1 ADP
% A
Cdk2(Y15P) Mik1-aT <--> Cdk2(Y15P)-Mik1-aT
% A
Cdk2(Y15P)-Mik1-aT --> Cdk2(T14PY15P) Mik1 ADP
% A
Cdk2(T160P) Mik1-aT <--> Cdk2(T160P)-Mik1-aT
% A
Cdk2(T160P)-Mik1-aT --> Cdk2(T14PT160P) Mik1 ADP
% A
Cdk2(Y15PT160P) Mik1-aT <--> Cdk2(Y15PT160P)-Mik1-aT
% A
Cdk2(Y15PT160P)-Mik1-aT --> Cdk2(T14PY15PT160P) Mik1 ADP
% A
Cdk2 Myt1-aT <--> Cdk2-Myt1-aT
% A
Cdk2-Myt1-aT --> Cdk2(T14P) Myt1 ADP
% A
Cdk2-Myt1-aT --> Cdk2(Y15P) Myt1 ADP
% A
Cdk2(T14P) Myt1-aT <--> Cdk2(T14P)-Myt1-aT
% A
Cdk2(T14P)-Myt1-aT --> Cdk2(T14PY15P) Myt1 ADP
% A
Cdk2(Y15P) Myt1-aT <--> Cdk2(Y15P)-Myt1-aT
% A
Cdk2(Y15P)-Myt1-aT --> Cdk2(T14PY15P) Myt1 ADP
% A
Cdk2(T160P) Myt1-aT <--> Cdk2(T160P)-Myt1-aT
% A
Cdk2(T160P)-Myt1-aT --> Cdk2(T14PT160P) Myt1 ADP
% A
Cdk2(T160P)-Myt1-aT --> Cdk2(Y15PT160P) Myt1 ADP
% A
Cdk2(T14PT160P) Myt1-aT <--> Cdk2(T14PT160P)-Myt1-aT
% A
Cdk2(T14PT160P)-Myt1-aT --> Cdk2(T14PY15PT160P) Myt1 ADP
% A
Cdk2(Y15PT160P) Myt1-aT <--> Cdk2(Y15PT160P)-Myt1-aT
% A
Cdk2(Y15PT160P)-Myt1-aT --> Cdk2(T14PY15PT160P) Myt1 ADP
% A # Natural hydrolysis
Cdk2(Y15P) --> Cdk2 P
% A
CycH-Cdk7 ATP <--> CycH-Cdk7-aT
% A
Cdk2 CycH-Cdk7-aT <--> Cdk2-CycH-Cdk7-aT
% A
Cdk2-CycH-Cdk7-aT --> Cdk2(T160P) CycH-Cdk7 ADP
% A
Cdk2(T14P) CycH-Cdk7-aT <--> Cdk2(T14P)-CycH-Cdk7-aT
% A
Cdk2(T14P)-CycH-Cdk7-aT --> Cdk2(T14PT160P) CycH-Cdk7 ADP
% A
Cdk2(Y15P) CycH-Cdk7-aT <--> Cdk2(Y15P)-CycH-Cdk7-aT
% A
Cdk2(Y15P)-CycH-Cdk7-aT --> Cdk2(Y15PT160P) CycH-Cdk7 ADP
% A
Cdk2(T14PY15P) CycH-Cdk7-aT <--> Cdk2(T14PY15P)-CycH-Cdk7-aT
% A
Cdk2(T14PY15P)-CycH-Cdk7-aT --> Cdk2(T14PY15PT160P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdk2(T160P) --> Cdk2 P
% A # Natural hydrolysis
Cdk2(T14PT160P) --> Cdk2(T14P) P
% A # Natural hydrolysis
Cdk2(T14PT160P) --> Cdk2(T160P) P
% A # Natural hydrolysis
Cdk2(Y15PT160P) --> Cdk2(Y15P) P
% A # Natural hydrolysis
Cdk2(Y15PT160P) --> Cdk2(T160P) P
% A # Natural hydrolysis
Cdk2(T14PY15PT160P) --> Cdk2(T14PY15P) P
% A # Natural hydrolysis
Cdk2(T14PY15PT160P) --> Cdk2(T14PT160P) P
% A # Natural hydrolysis
Cdk2(T14PY15PT160P) --> Cdk2(Y15PT160P) P
% A
CycE Cdk2 <--> CycE-Cdk2
% A
CycA Cdk2 <--> CycA-Cdk2
% A
CycE Cdk2(T14P) <--> CycE-Cdk2(T14P)
% A
CycA Cdk2(T14P) <--> CycA-Cdk2(T14P)
% A
CycE Cdk2(Y15P) <--> CycE-Cdk2(Y15P)
% A
CycA Cdk2(Y15P) <--> CycA-Cdk2(Y15P)
% A
CycE Cdk2(T14PY15P) <--> CycE-Cdk2(T14PY15P)
% A
CycA Cdk2(T14PY15P) <--> CycA-Cdk2(T14PY15P)
% A
CycE Cdk2(T160P) <--> CycE-Cdk2(T160P)
% A
CycA Cdk2(T160P) <--> CycA-Cdk2(T160P)
% A
CycE Cdk2(T14PT160P) <--> CycE-Cdk2(T14PT160P)
% A
CycA Cdk2(T14PT160P) <--> CycA-Cdk2(T14PT160P)
% A
CycE Cdk2(Y15PT160P) <--> CycE-Cdk2(Y15PT160P)
% A
CycA Cdk2(Y15PT160P) <--> CycA-Cdk2(Y15PT160P)
% A
CycE Cdk2(T14PY15PT160P) <--> CycE-Cdk2(T14PY15PT160P)
% A
CycA Cdk2(T14PY15PT160P) <--> CycA-Cdk2(T14PY15PT160P)
% A # Booher R.N.,1997
CycE-Cdk2 Wee1-aT <--> CycE-Cdk2-Wee1-aT
% A # Booher R.N.,1997
CycE-Cdk2-Wee1-aT --> CycE-Cdk2(T14P) Wee1 ADP
% A # Booher R.N.,1997
CycE-Cdk2(Y15P) Wee1-aT <--> CycE-Cdk2(Y15P)-Wee1-aT
% A # Booher R.N.,1997
CycE-Cdk2(Y15P)-Wee1-aT --> CycE-Cdk2(T14PY15P) Wee1 ADP
% A # Booher R.N.,1997
CycA-Cdk2 Wee1-aT <--> CycA-Cdk2-Wee1-aT
% A # Booher R.N.,1997
CycA-Cdk2-Wee1-aT --> CycA-Cdk2(T14P) Wee1 ADP
% A # Booher R.N.,1997
CycA-Cdk2(Y15P) Wee1-aT <--> CycA-Cdk2(Y15P)-Wee1-aT
% A # Booher R.N.,1997
CycA-Cdk2(Y15P)-Wee1-aT --> CycA-Cdk2(T14PY15P) Wee1 ADP
% A # Natural hydrolysis
CycE-Cdk2(T14P) --> CycE-Cdk2 P
% A # Natural hydrolysis
CycE-Cdk2(Y15P) --> CycE-Cdk2 P
% A # Natural hydrolysis
CycE-Cdk2(T14PY15P) --> CycE-Cdk2(Y15P) P
% A # Natural hydrolysis
CycE-Cdk2(T14PY15P) --> CycE-Cdk2(T14P) P
% A # Natural hydrolysis
CycA-Cdk2(T14P) --> CycA-Cdk2 P
% A # Natural hydrolysis
CycA-Cdk2(Y15P) --> CycA-Cdk2 P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15P) --> CycA-Cdk2(Y15P) P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15P) --> CycA-Cdk2(T14P) P
% A
CycE-Cdk2 Mik1-aT <--> CycE-Cdk2-Mik1-aT
% A
CycE-Cdk2-Mik1-aT --> CycE-Cdk2(T14P) Mik1 ADP
% A
CycE-Cdk2(Y15P) Mik1-aT <--> CycE-Cdk2(Y15P)-Mik1-aT
% A
CycE-Cdk2(Y15P)-Mik1-aT --> CycE-Cdk2(T14PY15P) Mik1 ADP
% A
CycA-Cdk2 Mik1-aT <--> CycA-Cdk2-Mik1-aT
% A
CycA-Cdk2-Mik1-aT --> CycA-Cdk2(T14P) Mik1 ADP
% A
CycA-Cdk2(Y15P) Mik1-aT <--> CycA-Cdk2(Y15P)-Mik1-aT
% A
CycA-Cdk2(Y15P)-Mik1-aT --> CycA-Cdk2(T14PY15P) Mik1 ADP
% A
CycE-Cdk2 Myt1-aT <--> CycE-Cdk2-Myt1-aT
% A
CycE-Cdk2-Myt1-aT --> CycE-Cdk2(T14P) Myt1 ADP
% A
CycE-Cdk2-Myt1-aT --> CycE-Cdk2(Y15P) Myt1 ADP
% A
CycE-Cdk2(T14P) Myt1-aT <--> CycE-Cdk2(T14P)-Myt1-aT
% A
CycE-Cdk2(T14P)-Myt1-aT --> CycE-Cdk2(T14PY15P) Myt1 ADP
% A
CycE-Cdk2(Y15P) Myt1-aT <--> CycE-Cdk2(Y15P)-Myt1-aT
% A
CycE-Cdk2(Y15P)-Myt1-aT --> CycE-Cdk2(T14PY15P) Myt1 ADP
% A
CycA-Cdk2 Myt1-aT <--> CycA-Cdk2-Myt1-aT
% A
CycA-Cdk2-Myt1-aT --> CycA-Cdk2(T14P) Myt1 ADP
% A
CycA-Cdk2-Myt1-aT --> CycA-Cdk2(Y15P) Myt1 ADP
% A
CycA-Cdk2(T14P) Myt1-aT <--> CycA-Cdk2(T14P)-Myt1-aT
% A
CycA-Cdk2(T14P)-Myt1-aT --> CycA-Cdk2(T14PY15P) Myt1 ADP
% A
CycA-Cdk2(Y15P) Myt1-aT <--> CycA-Cdk2(Y15P)-Myt1-aT
% A
CycA-Cdk2(Y15P)-Myt1-aT --> CycA-Cdk2(T14PY15P) Myt1 ADP
% A
CycE-Cdk2(T14PY15P) CycH-Cdk7-aT <--> CycE-Cdk2(T14PY15P)-CycH-Cdk7-aT
% A
CycE-Cdk2(T14PY15P)-CycH-Cdk7-aT --> CycE-Cdk2(T14PY15PT160P) CycH-Cdk7 ADP
% A
CycA-Cdk2(T14PY15P) CycH-Cdk7-aT <--> CycA-Cdk2(T14PY15P)-CycH-Cdk7-aT
% A
CycA-Cdk2(T14PY15P)-CycH-Cdk7-aT --> CycA-Cdk2(T14PY15PT160P) CycH-Cdk7 ADP
% A # Natural hydrolysis
CycE-Cdk2(T14PY15PT160P) --> CycE-Cdk2(T14PY15P) P
% A # Natural hydrolysis
CycE-Cdk2(T14PY15PT160P) --> CycE-Cdk2(T14PT160P) P
% A # Natural hydrolysis
CycE-Cdk2(T14PY15PT160P) --> CycE-Cdk2(Y15PT160P) P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15PT160P) --> CycA-Cdk2(T14PY15P) P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15PT160P) --> CycA-Cdk2(T14PT160P) P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15PT160P) --> CycA-Cdk2(Y15PT160P) P
% A
CycE-Cdk2(T14P) Cdc25A <--> CycE-Cdk2(T14P)-Cdc25A
% A # Natural hydrolysis
CycE-Cdk2(T14P)-Cdc25A --> CycE-Cdk2 Cdc25A P
% A
CycE-Cdk2(Y15P) Cdc25A <--> CycE-Cdk2(Y15P)-Cdc25A
% A # Natural hydrolysis
CycE-Cdk2(Y15P)-Cdc25A --> CycE-Cdk2 Cdc25A P
% A
CycE-Cdk2(T14PY15P) Cdc25A <--> CycE-Cdk2(T14PY15P)-Cdc25A
% A # Natural hydrolysis
CycE-Cdk2(T14PY15P)-Cdc25A --> CycE-Cdk2(T14P) Cdc25A P
% A # Natural hydrolysis
CycE-Cdk2(T14PY15P)-Cdc25A --> CycE-Cdk2(Y15P) Cdc25A P
% A
CycE-Cdk2(T14PT160P) Cdc25A <--> CycE-Cdk2(T14PT160P)-Cdc25A
% A # Natural hydrolysis
CycE-Cdk2(T14PT160P)-Cdc25A --> CycE-Cdk2(T160P) Cdc25A P
% A
CycE-Cdk2(Y15PT160P) Cdc25A <--> CycE-Cdk2(Y15PT160P)-Cdc25A
% A # Natural hydrolysis
CycE-Cdk2(Y15PT160P)-Cdc25A --> CycE-Cdk2(T160P) Cdc25A P
% A
CycE-Cdk2(T14PY15PT160P) Cdc25A <--> CycE-Cdk2(T14PY15PT160P)-Cdc25A
% A # Natural hydrolysis
CycE-Cdk2(T14PY15PT160P)-Cdc25A --> CycE-Cdk2(T14PT160P) Cdc25A P
% A # Natural hydrolysis
CycE-Cdk2(T14PY15PT160P)-Cdc25A --> CycE-Cdk2(Y15PT160P) Cdc25A P
% A
CycE-Cdk2(T160P) KAP <--> CycE-Cdk2(T160P)-KAP
% A # Natural hydrolysis
CycE-Cdk2(T160P)-KAP --> CycE-Cdk2 KAP P
% A
CycE-Cdk2(T14PT160P) KAP <--> CycE-Cdk2(T14PT160P)-KAP
% A # Natural hydrolysis
CycE-Cdk2(T14PT160P)-KAP --> CycE-Cdk2(T14P) KAP P
% A
CycE-Cdk2(Y15PT160P) KAP <--> CycE-Cdk2(Y15PT160P)-KAP
% A # Natural hydrolysis
CycE-Cdk2(Y15PT160P)-KAP --> CycE-Cdk2(Y15P) KAP P
% A
CycE-Cdk2(T14PY15PT160P) KAP <--> CycE-Cdk2(T14PY15PT160P)-KAP
% A # Natural hydrolysis
CycE-Cdk2(T14PY15PT160P)-KAP --> CycE-Cdk2(T14PY15P) KAP P
% A
CycA-Cdk2(T14P) Cdc25A <--> CycA-Cdk2(T14P)-Cdc25A
% A # Natural hydrolysis
CycA-Cdk2(T14P)-Cdc25A --> CycA-Cdk2 Cdc25A P
% A
CycA-Cdk2(Y15P) Cdc25A <--> CycA-Cdk2(Y15P)-Cdc25A
% A # Natural hydrolysis
CycA-Cdk2(Y15P)-Cdc25A --> CycA-Cdk2 Cdc25A P
% A
CycA-Cdk2(T14PY15P) Cdc25A <--> CycA-Cdk2(T14PY15P)-Cdc25A
% A # Natural hydrolysis
CycA-Cdk2(T14PY15P)-Cdc25A --> CycA-Cdk2(T14P) Cdc25A P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15P)-Cdc25A --> CycA-Cdk2(Y15P) Cdc25A P
% A
CycA-Cdk2(T14PT160P) Cdc25A <--> CycA-Cdk2(T14PT160P)-Cdc25A
% A # Natural hydrolysis
CycA-Cdk2(T14PT160P)-Cdc25A --> CycA-Cdk2(T160P) Cdc25A P
% A
CycA-Cdk2(Y15PT160P) Cdc25A <--> CycA-Cdk2(Y15PT160P)-Cdc25A
% A # Natural hydrolysis
CycA-Cdk2(Y15PT160P)-Cdc25A --> CycA-Cdk2(T160P) Cdc25A P
% A
CycA-Cdk2(T14PY15PT160P) Cdc25A <--> CycA-Cdk2(T14PY15PT160P)-Cdc25A
% A # Natural hydrolysis
CycA-Cdk2(T14PY15PT160P)-Cdc25A --> CycA-Cdk2(T14PT160P) Cdc25A P
% A # Natural hydrolysis
CycA-Cdk2(T14PY15PT160P)-Cdc25A --> CycA-Cdk2(Y15PT160P) Cdc25A P
% A
CycA-Cdk2(T160P) KAP <--> CycA-Cdk2(T160P)-KAP
% A # Natural hydrolysis
CycA-Cdk2(T160P)-KAP --> CycA-Cdk2 KAP P
% A
CycA-Cdk2(T14PT160P) KAP <--> CycA-Cdk2(T14PT160P)-KAP
% A # Natural hydrolysis
CycA-Cdk2(T14PT160P)-KAP --> CycA-Cdk2(T14P) KAP P
% A
CycA-Cdk2(Y15PT160P) KAP <--> CycA-Cdk2(Y15PT160P)-KAP
% A # Natural hydrolysis
CycA-Cdk2(Y15PT160P)-KAP --> CycA-Cdk2(Y15P) KAP P
% A
CycA-Cdk2(T14PY15PT160P) KAP <--> CycA-Cdk2(T14PY15PT160P)-KAP
% A # Natural hydrolysis
CycA-Cdk2(T14PY15PT160P)-KAP --> CycA-Cdk2(T14PY15P) KAP P
% A
CycE-Cdk2(T160P) GSKn-aT <--> CycE-Cdk2(T160P)-GSKn-aT
% A
CycE-Cdk2(T160P)-GSKn-aT --> CycE(P) Cdk2(T160P) GSKn ADP
% A # Natural hydrolysis
CycE(P) --> CycE P
% A
CycA-Cdk2(T160P) GSKn-aT <--> CycA-Cdk2(T160P)-GSKn-aT
% A
CycA-Cdk2(T160P)-GSKn-aT --> CycA(P) Cdk2(T160P) GSKn ADP
% A # Natural hydrolysis
CycA(P) --> CycA P
% A
CycE-Cdk2(T160P) ATP <--> CycE-Cdk2(T160P)-aT
% A
CycE-Cdk2(T160P)-aT --> CycE(P) Cdk2(T160P) ADP
% A # Winston J.T.1999, Nakayama K. 2000
CycE(P) SCF-nUb <--> CycE{P(nUb)} SCF
% A
Cdc20-Apcs nUb <--> Cdc20-Apcs-nUb
% A
CycA(P) Cdc20-Apcs-nUb <--> CycA{P(nUb)} Cdc20-Apcs
% A
P21(P) SCF-nUb <--> P21{P(nUb)} SCF
% A # Carrano 1999
P27(T187P) SCF-nUb <--> P27{T187P(nUb)} SCF
% A # Fujita 2002
ORC(P) SCF-nUb <--> ORC{P(nUb)} SCF
% A
Cdc6(P) SCF-nUb <--> Cdc6c{P(nUb)} SCF
% A
CycE{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
CycA{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
P21{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
P27{T187P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
ORC{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
Cdc6c{P(nUb)} Proteasome --> Peptides nUb Proteasome
% B
Cdc6(P) nCL4 --> Peptides nCL4
% A # Nath, 1999
CycE-Cdk2(T160P)-aT Rb-E2F <--> CycE-Cdk2(T160P)-aT-Rb-E2F
% A
CycE-Cdk2(T160P)-aT-Rb-E2F --> CycE-Cdk2(T160P) ADP Rb(P) E2F
% A # Nath, 1999
CycE-Cdk2(T160P)-aT P21 <--> CycE-Cdk2(T160P)-aT-P21
% A
CycE-Cdk2(T160P)-aT-P21 --> CycE-Cdk2(T160P) ADP P21(P)
% A
CycE-Cdk2(T160P)-aT P27 <--> CycE-Cdk2(T160P)-aT-P27
% A
CycE-Cdk2(T160P)-aT-P27 --> CycE-Cdk2(T160P) ADP P27(T187P)
% A
CycE-Cdk2(T160P)-aT DP1 <--> CycE-Cdk2(T160P)-aT-DP1
% A
CycE-Cdk2(T160P)-aT-DP1 --> CycE-Cdk2(T160P) ADP DP1(P)
% A
CycA-Cdk2(T160P) ATP <--> CycA-Cdk2(T160P)-aT
% A
CycA-Cdk2(T160P)-aT E2F-SP1 <--> CycA-Cdk2(T160P)-aT-E2F-SP1
% A
CycA-Cdk2(T160P)-aT-E2F-SP1 --> CycA-Cdk2(T160P) ADP E2F-SP1(P)
% A
CycA-Cdk2(T160P)-aT Cdc6 <--> CycA-Cdk2(T160P)-aT-Cdc6
% A
CycA-Cdk2(T160P)-aT-Cdc6 --> CycA-Cdk2(T160P) ADP Cdc6(P)
% A # Arata 2000
CycA-Cdk2(T160P)-aT Cdc45 <--> CycA-Cdk2(T160P)-aT-Cdc45
% A
CycA-Cdk2(T160P)-aT-Cdc45 --> CycA-Cdk2(T160P) ADP Cdc45(P)
% A
CycA-Cdk2(T160P)-aT ORC <--> CycA-Cdk2(T160P)-aT-ORC
% A
CycA-Cdk2(T160P)-aT-ORC --> CycA-Cdk2(T160P) ADP ORC(P)
% A # Cardoso 1993
CycA-Cdk2(T160P)-aT MCM <--> CycA-Cdk2(T160P)-aT-MCM
% A
CycA-Cdk2(T160P)-aT-MCM --> CycA-Cdk2(T160P) ADP MCM(P)
% A # Natural hydrolysis
Rb(P) --> Rb P
% A # Natural hydrolysis
P21(P) --> P21 P
% A # Natural hydrolysis
P27(T187P) --> P27 P
% A # Natural hydrolysis
DP1(P) --> DP1 P
% A # Natural hydrolysis
E2F-SP1(P) --> E2F-SP1 P
% A # Natural hydrolysis
Cdc6(P) --> Cdc6 P
% A # Natural hydrolysis
Cdc45(P) --> Cdc45 P
% A # Natural hydrolysis
ORC(P) --> ORC P
% A # Natural hydrolysis
MCM(P) --> MCM P
% A
14_3_3_sigma(g) 4P53 --> 14_3_3_sigma(r) 4P53
% A
14_3_3_sigma(r) --> 14_3_3_sigma
% A
14_3_3_sigma Cdc2(T161P) --> 14_3_3_sigma-Cdc2(T161P)n
% A
14_3_3_sigma-Cdc2(T161P)n --> 14_3_3_sigma-Cdc2(T161P)c
% A
ATM-aT Chk2 <--> ATM-aT-Chk2
% A
ATM-aT-Chk2 --> ATM ADP Chk2(P)
% A
Chk2(P) ATP <--> Chk2(P)-aT
% A # Natural hydrolysis
Chk2(P) --> Chk2 P
% A
Chk2(P)-aT Cdc25C --> Chk2(P) ADP Cdc25C(P)
% A # Natural hydrolysis
Cdc25C(P) --> Cdc25C P
% A
Cdc25C(P) 14_3_3_sigma <--> Cdc25C(P)-14_3_3_sigman
% A
Cdc25C(P)-14_3_3_sigman --> Cdc25C(P)-14_3_3_sigmac
% A
Cdc2 Wee1-aT <--> Cdc2-Wee1-aT
% A
Cdc2-Wee1-aT --> Cdc2(T14P) Wee1 ADP
% A
Cdc2(Y15P) Wee1-aT <--> Cdc2(Y15P)-Wee1-aT
% A
Cdc2(Y15P)-Wee1-aT --> Cdc2(T14PY15P) Wee1 ADP
% A
Cdc2(T161P) Wee1-aT <--> Cdc2(T161P)-Wee1-aT
% A
Cdc2(T161P)-Wee1-aT --> Cdc2(T14PT161P) Wee1 ADP
% A
Cdc2(Y15PT161P) Wee1-aT <--> Cdc2(Y15PT161P)-Wee1-aT
% A
Cdc2(Y15PT161P)-Wee1-aT --> Cdc2(T14PY15PT161P) Wee1 ADP
% A # Natural hydrolysis
Cdc2(T14P) --> Cdc2 P
% A # Natural hydrolysis
Cdc2(T14PY15P) --> Cdc2(Y15P) P
% A # Natural hydrolysis
Cdc2(T14PY15P) --> Cdc2(T14P) P
% A
Cdc2 Mik1-aT <--> Cdc2-Mik1-aT
% A
Cdc2-Mik1-aT --> Cdc2(T14P) Mik1 ADP
% A
Cdc2(Y15P) Mik1-aT <--> Cdc2(Y15P)-Mik1-aT
% A
Cdc2(Y15P)-Mik1-aT --> Cdc2(T14PY15P) Mik1 ADP
% A
Cdc2(T161P) Mik1-aT <--> Cdc2(T161P)-Mik1-aT
% A
Cdc2(T161P)-Mik1-aT --> Cdc2(T14PT161P) Mik1 ADP
% A
Cdc2(Y15PT161P) Mik1-aT <--> Cdc2(Y15PT161P)-Mik1-aT
% A
Cdc2(Y15PT161P)-Mik1-aT --> Cdc2(T14PY15PT161P) Mik1 ADP
% A
Cdc2 Myt1-aT <--> Cdc2-Myt1-aT
% A
Cdc2-Myt1-aT --> Cdc2(T14P) Myt1 ADP
% A
Cdc2-Myt1-aT --> Cdc2(Y15P) Myt1 ADP
% A
Cdc2(T14P) Myt1-aT <--> Cdc2(T14P)-Myt1-aT
% A
Cdc2(T14P)-Myt1-aT --> Cdc2(T14PY15P) Myt1 ADP
% A
Cdc2(Y15P) Myt1-aT <--> Cdc2(Y15P)-Myt1-aT
% A
Cdc2(Y15P)-Myt1-aT --> Cdc2(T14PY15P) Myt1 ADP
% A
Cdc2(T161P) Myt1-aT <--> Cdc2(T161P)-Myt1-aT
% A
Cdc2(T161P)-Myt1-aT --> Cdc2(T14PT161P) Myt1 ADP
% A
Cdc2(T161P)-Myt1-aT --> Cdc2(Y15PT161P) Myt1 ADP
% A
Cdc2(T14PT161P) Myt1-aT <--> Cdc2(T14PT161P)-Myt1-aT
% A
Cdc2(T14PT161P)-Myt1-aT --> Cdc2(T14PY15PT161P) Myt1 ADP
% A
Cdc2(Y15PT161P) Myt1-aT <--> Cdc2(Y15PT161P)-Myt1-aT
% A
Cdc2(Y15PT161P)-Myt1-aT --> Cdc2(T14PY15PT161P) Myt1 ADP
% A # Natural hydrolysis
Cdc2(Y15P) --> Cdc2 P
% A
Cdc2 CycH-Cdk7-aT <--> Cdc2-CycH-Cdk7-aT
% A
Cdc2-CycH-Cdk7-aT --> Cdc2(T161P) CycH-Cdk7 ADP
% A
Cdc2(T14P) CycH-Cdk7-aT <--> Cdc2(T14P)-CycH-Cdk7-aT
% A
Cdc2(T14P)-CycH-Cdk7-aT --> Cdc2(T14PT161P) CycH-Cdk7 ADP
% A
Cdc2(Y15P) CycH-Cdk7-aT <--> Cdc2(Y15P)-CycH-Cdk7-aT
% A
Cdc2(Y15P)-CycH-Cdk7-aT --> Cdc2(Y15PT161P) CycH-Cdk7 ADP
% A
Cdc2(T14PY15P) CycH-Cdk7-aT <--> Cdc2(T14PY15P)-CycH-Cdk7-aT
% A
Cdc2(T14PY15P)-CycH-Cdk7-aT --> Cdc2(T14PY15PT161P) CycH-Cdk7 ADP
% A # Natural hydrolysis
Cdc2(T161P) --> Cdc2 P
% A # Natural hydrolysis
Cdc2(T14PT161P) --> Cdc2(T14P) P
% A # Natural hydrolysis
Cdc2(T14PT161P) --> Cdc2(T161P) P
% A # Natural hydrolysis
Cdc2(Y15PT161P) --> Cdc2(Y15P) P
% A # Natural hydrolysis
Cdc2(Y15PT161P) --> Cdc2(T161P) P
% A # Natural hydrolysis
Cdc2(T14PY15PT161P) --> Cdc2(T14PY15P) P
% A # Natural hydrolysis
Cdc2(T14PY15PT161P) --> Cdc2(T14PT161P) P
% A # Natural hydrolysis
Cdc2(T14PY15PT161P) --> Cdc2(Y15PT161P) P
% A
CycA Cdc2 <--> CycA-Cdc2
% A
CycB Cdc2 <--> CycB-Cdc2
% A
CycA Cdc2(T14P) <--> CycA-Cdc2(T14P)
% A
CycB Cdc2(T14P) <--> CycB-Cdc2(T14P)
% A
CycA Cdc2(Y15P) <--> CycA-Cdc2(Y15P)
% A
CycB Cdc2(Y15P) <--> CycB-Cdc2(Y15P)
% A
CycA Cdc2(T14PY15P) <--> CycA-Cdc2(T14PY15P)
% A
CycB Cdc2(T14PY15P) <--> CycB-Cdc2(T14PY15P)
% A
CycA Cdc2(T161P) <--> CycA-Cdc2(T161P)
% A
CycB Cdc2(T161P) <--> CycB-Cdc2(T161P)
% A
CycA Cdc2(T14PT161P) <--> CycA-Cdc2(T14PT161P)
% A
CycB Cdc2(T14PT161P) <--> CycB-Cdc2(T14PT161P)
% A
CycA Cdc2(Y15PT161P) <--> CycA-Cdc2(Y15PT161P)
% A
CycB Cdc2(Y15PT161P) <--> CycB-Cdc2(Y15PT161P)
% A
CycA Cdc2(T14PY15PT161P) <--> CycA-Cdc2(T14PY15PT161P)
% A
CycB Cdc2(T14PY15PT161P) <--> CycB-Cdc2(T14PY15PT161P)
% A # Booher R.N.,1997
CycB-Cdc2 Wee1-aT <--> CycB-Cdc2-Wee1-aT
% A # Booher R.N.,1997
CycB-Cdc2-Wee1-aT --> CycB-Cdc2(T14P) Wee1 ADP
% A # Booher R.N.,1997
CycB-Cdc2(Y15P) Wee1-aT <--> CycB-Cdc2(Y15P)-Wee1-aT
% A # Booher R.N.,1997
CycB-Cdc2(Y15P)-Wee1-aT --> CycB-Cdc2(T14PY15P) Wee1 ADP
% A # Booher R.N.,1997
CycA-Cdc2 Wee1-aT <--> CycA-Cdc2-Wee1-aT
% A # Booher R.N.,1997
CycA-Cdc2-Wee1-aT --> CycA-Cdc2(T14P) Wee1 ADP
% A # Booher R.N.,1997
CycA-Cdc2(Y15P) Wee1-aT <--> CycA-Cdc2(Y15P)-Wee1-aT
% A # Booher R.N.,1997
CycA-Cdc2(Y15P)-Wee1-aT --> CycA-Cdc2(T14PY15P) Wee1 ADP
% A # Natural hydrolysis
CycB-Cdc2(T14P) --> CycB-Cdc2 P
% A # Natural hydrolysis
CycB-Cdc2(Y15P) --> CycB-Cdc2 P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15P) --> CycB-Cdc2(Y15P) P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15P) --> CycB-Cdc2(T14P) P
% A # Natural hydrolysis
CycA-Cdc2(T14P) --> CycA-Cdc2 P
% A # Natural hydrolysis
CycA-Cdc2(Y15P) --> CycA-Cdc2 P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15P) --> CycA-Cdc2(Y15P) P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15P) --> CycA-Cdc2(T14P) P
% A
CycB-Cdc2 Mik1-aT <--> CycB-Cdc2-Mik1-aT
% A
CycB-Cdc2-Mik1-aT --> CycB-Cdc2(T14P) Mik1 ADP
% A
CycB-Cdc2(Y15P) Mik1-aT <--> CycB-Cdc2(Y15P)-Mik1-aT
% A
CycB-Cdc2(Y15P)-Mik1-aT --> CycB-Cdc2(T14PY15P) Mik1 ADP
% A
CycA-Cdc2 Mik1-aT <--> CycA-Cdc2-Mik1-aT
% A
CycA-Cdc2-Mik1-aT --> CycA-Cdc2(T14P) Mik1 ADP
% A
CycA-Cdc2(Y15P) Mik1-aT <--> CycA-Cdc2(Y15P)-Mik1-aT
% A
CycA-Cdc2(Y15P)-Mik1-aT --> CycA-Cdc2(T14PY15P) Mik1 ADP
% A
CycB-Cdc2 Myt1-aT <--> CycB-Cdc2-Myt1-aT
% A
CycB-Cdc2-Myt1-aT --> CycB-Cdc2(T14P) Myt1 ADP
% A
CycB-Cdc2-Myt1-aT --> CycB-Cdc2(Y15P) Myt1 ADP
% A
CycB-Cdc2(T14P) Myt1-aT <--> CycB-Cdc2(T14P)-Myt1-aT
% A
CycB-Cdc2(T14P)-Myt1-aT --> CycB-Cdc2(T14PY15P) Myt1 ADP
% A
CycB-Cdc2(Y15P) Myt1-aT <--> CycB-Cdc2(Y15P)-Myt1-aT
% A
CycB-Cdc2(Y15P)-Myt1-aT --> CycB-Cdc2(T14PY15P) Myt1 ADP
% A
CycA-Cdc2 Myt1-aT <--> CycA-Cdc2-Myt1-aT
% A
CycA-Cdc2-Myt1-aT --> CycA-Cdc2(T14P) Myt1 ADP
% A
CycA-Cdc2-Myt1-aT --> CycA-Cdc2(Y15P) Myt1 ADP
% A
CycA-Cdc2(T14P) Myt1-aT <--> CycA-Cdc2(T14P)-Myt1-aT
% A
CycA-Cdc2(T14P)-Myt1-aT --> CycA-Cdc2(T14PY15P) Myt1 ADP
% A
CycA-Cdc2(Y15P) Myt1-aT <--> CycA-Cdc2(Y15P)-Myt1-aT
% A
CycA-Cdc2(Y15P)-Myt1-aT --> CycA-Cdc2(T14PY15P) Myt1 ADP
% A
CycB-Cdc2(T14PY15P) CycH-Cdk7-aT <--> CycB-Cdc2(T14PY15P)-CycH-Cdk7-aT
% A
CycB-Cdc2(T14PY15P)-CycH-Cdk7-aT --> CycB-Cdc2(T14PY15PT161P) CycH-Cdk7 ADP
% A
CycA-Cdc2(T14PY15P) CycH-Cdk7-aT <--> CycA-Cdc2(T14PY15P)-CycH-Cdk7-aT
% A
CycA-Cdc2(T14PY15P)-CycH-Cdk7-aT --> CycA-Cdc2(T14PY15PT161P) CycH-Cdk7 ADP
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P) --> CycB-Cdc2(T14PY15P) P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P) --> CycB-Cdc2(T14PT161P) P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P) --> CycB-Cdc2(Y15PT161P) P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P) --> CycA-Cdc2(T14PY15P) P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P) --> CycA-Cdc2(T14PT161P) P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P) --> CycA-Cdc2(Y15PT161P) P
% A
CycA-Cdc2(T14P) Cdc25B <--> CycA-Cdc2(T14P)-Cdc25B
% A # Natural hydrolysis
CycA-Cdc2(T14P)-Cdc25B --> CycA-Cdc2 Cdc25B P
% A
CycA-Cdc2(Y15P) Cdc25B <--> CycA-Cdc2(Y15P)-Cdc25B
% A # Natural hydrolysis
CycA-Cdc2(Y15P)-Cdc25B --> CycA-Cdc2 Cdc25B P
% A
CycA-Cdc2(T14PY15P) Cdc25B <--> CycA-Cdc2(T14PY15P)-Cdc25B
% A # Natural hydrolysis
CycA-Cdc2(T14PY15P)-Cdc25B --> CycA-Cdc2(T14P) Cdc25B P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15P)-Cdc25B --> CycA-Cdc2(Y15P) Cdc25B P
% A
CycA-Cdc2(T14PT161P) Cdc25B <--> CycA-Cdc2(T14PT161P)-Cdc25B
% A # Natural hydrolysis
CycA-Cdc2(T14PT161P)-Cdc25B --> CycA-Cdc2(T161P) Cdc25B P
% A
CycA-Cdc2(Y15PT161P) Cdc25B <--> CycA-Cdc2(Y15PT161P)-Cdc25B
% A # Natural hydrolysis
CycA-Cdc2(Y15PT161P)-Cdc25B --> CycA-Cdc2(T161P) Cdc25B P
% A
CycA-Cdc2(T14PY15PT161P) Cdc25B <--> CycA-Cdc2(T14PY15PT161P)-Cdc25B
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P)-Cdc25B --> CycA-Cdc2(T14PT161P) Cdc25B P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P)-Cdc25B --> CycA-Cdc2(Y15PT161P) Cdc25B P
% A
CycA-Cdc2(T14P) Cdc25C(S/TP) <--> CycA-Cdc2(T14P)-Cdc25C(S/TP)
% A # Natural hydrolysis
CycA-Cdc2(T14P)-Cdc25C(S/TP) --> CycA-Cdc2 Cdc25C(S/TP) P
% A
CycA-Cdc2(Y15P) Cdc25C(S/TP) <--> CycA-Cdc2(Y15P)-Cdc25C(S/TP)
% A # Natural hydrolysis
CycA-Cdc2(Y15P)-Cdc25C(S/TP) --> CycA-Cdc2 Cdc25C(S/TP) P
% A
CycA-Cdc2(T14PY15P) Cdc25C(S/TP) <--> CycA-Cdc2(T14PY15P)-Cdc25C(S/TP)
% A # Natural hydrolysis
CycA-Cdc2(T14PY15P)-Cdc25C(S/TP) --> CycA-Cdc2(T14P) Cdc25C(S/TP) P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15P)-Cdc25C(S/TP) --> CycA-Cdc2(Y15P) Cdc25C(S/TP) P
% A
CycA-Cdc2(T14PT161P) Cdc25C(S/TP) <--> CycA-Cdc2(T14PT161P)-Cdc25C(S/TP)
% A # Natural hydrolysis
CycA-Cdc2(T14PT161P)-Cdc25C(S/TP) --> CycA-Cdc2(T161P) Cdc25C(S/TP) P
% A
CycA-Cdc2(Y15PT161P) Cdc25C(S/TP) <--> CycA-Cdc2(Y15PT161P)-Cdc25C(S/TP)
% A # Natural hydrolysis
CycA-Cdc2(Y15PT161P)-Cdc25C(S/TP) --> CycA-Cdc2(T161P) Cdc25C(S/TP) P
% A
CycA-Cdc2(T14PY15PT161P) Cdc25C(S/TP) <--> CycA-Cdc2(T14PY15PT161P)-Cdc25C(S/TP)
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P)-Cdc25C(S/TP) --> CycA-Cdc2(T14PT161P) Cdc25C(S/TP) P
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P)-Cdc25C(S/TP) --> CycA-Cdc2(Y15PT161P) Cdc25C(S/TP) P
% A
CycA-Cdc2(T161P) KAP <--> CycA-Cdc2(T161P)-KAP
% A # Natural hydrolysis
CycA-Cdc2(T161P)-KAP --> CycA-Cdc2 KAP P
% A
CycA-Cdc2(T14PT161P) KAP <--> CycA-Cdc2(T14PT161P)-KAP
% A # Natural hydrolysis
CycA-Cdc2(T14PT161P)-KAP --> CycA-Cdc2(T14P) KAP P
% A
CycA-Cdc2(Y15PT161P) KAP <--> CycA-Cdc2(Y15PT161P)-KAP
% A # Natural hydrolysis
CycA-Cdc2(Y15PT161P)-KAP --> CycA-Cdc2(Y15P) KAP P
% A
CycA-Cdc2(T14PY15PT161P) KAP <--> CycA-Cdc2(T14PY15PT161P)-KAP
% A # Natural hydrolysis
CycA-Cdc2(T14PY15PT161P)-KAP --> CycA-Cdc2(T14PY15P) KAP P
% A
CycB-Cdc2(T14P) Cdc25B <--> CycB-Cdc2(T14P)-Cdc25B
% A # Natural hydrolysis
CycB-Cdc2(T14P)-Cdc25B --> CycB-Cdc2 Cdc25B P
% A
CycB-Cdc2(Y15P) Cdc25B <--> CycB-Cdc2(Y15P)-Cdc25B
% A # Natural hydrolysis
CycB-Cdc2(Y15P)-Cdc25B --> CycB-Cdc2 Cdc25B P
% A
CycB-Cdc2(T14PY15P) Cdc25B <--> CycB-Cdc2(T14PY15P)-Cdc25B
% A # Natural hydrolysis
CycB-Cdc2(T14PY15P)-Cdc25B --> CycB-Cdc2(T14P) Cdc25B P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15P)-Cdc25B --> CycB-Cdc2(Y15P) Cdc25B P
% A
CycB-Cdc2(T14PT161P) Cdc25B <--> CycB-Cdc2(T14PT161P)-Cdc25B
% A # Natural hydrolysis
CycB-Cdc2(T14PT161P)-Cdc25B --> CycB-Cdc2(T161P) Cdc25B P
% A
CycB-Cdc2(Y15PT161P) Cdc25B <--> CycB-Cdc2(Y15PT161P)-Cdc25B
% A # Natural hydrolysis
CycB-Cdc2(Y15PT161P)-Cdc25B --> CycB-Cdc2(T161P) Cdc25B P
% A
CycB-Cdc2(T14PY15PT161P) Cdc25B <--> CycB-Cdc2(T14PY15PT161P)-Cdc25B
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P)-Cdc25B --> CycB-Cdc2(T14PT161P) Cdc25B P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P)-Cdc25B --> CycB-Cdc2(Y15PT161P) Cdc25B P
% A
CycB-Cdc2(T14P) Cdc25C <--> CycB-Cdc2(T14P)-Cdc25C
% A # Natural hydrolysis
CycB-Cdc2(T14P)-Cdc25C --> CycB-Cdc2 Cdc25C P
% A
CycB-Cdc2(Y15P) Cdc25C <--> CycB-Cdc2(Y15P)-Cdc25C
% A # Natural hydrolysis
CycB-Cdc2(Y15P)-Cdc25C --> CycB-Cdc2 Cdc25C P
% A
CycB-Cdc2(T14PY15P) Cdc25C <--> CycB-Cdc2(T14PY15P)-Cdc25C
% A # Natural hydrolysis
CycB-Cdc2(T14PY15P)-Cdc25C --> CycB-Cdc2(T14P) Cdc25C P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15P)-Cdc25C --> CycB-Cdc2(Y15P) Cdc25C P
% A
CycB-Cdc2(T14PT161P) Cdc25C <--> CycB-Cdc2(T14PT161P)-Cdc25C
% A # Natural hydrolysis
CycB-Cdc2(T14PT161P)-Cdc25C --> CycB-Cdc2(T161P) Cdc25C P
% A
CycB-Cdc2(Y15PT161P) Cdc25C <--> CycB-Cdc2(Y15PT161P)-Cdc25C
% A # Natural hydrolysis
CycB-Cdc2(Y15PT161P)-Cdc25C --> CycB-Cdc2(T161P) Cdc25C P
% A
CycB-Cdc2(T14PY15PT161P) Cdc25C <--> CycB-Cdc2(T14PY15PT161P)-Cdc25C
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P)-Cdc25C --> CycB-Cdc2(T14PT161P) Cdc25C P
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P)-Cdc25C --> CycB-Cdc2(Y15PT161P) Cdc25C P
% A
CycB-Cdc2(T161P) KAP <--> CycB-Cdc2(T161P)-KAP
% A # Natural hydrolysis
CycB-Cdc2(T161P)-KAP --> CycB-Cdc2 KAP P
% A
CycB-Cdc2(T14PT161P) KAP <--> CycB-Cdc2(T14PT161P)-KAP
% A # Natural hydrolysis
CycB-Cdc2(T14PT161P)-KAP --> CycB-Cdc2(T14P) KAP P
% A
CycB-Cdc2(Y15PT161P) KAP <--> CycB-Cdc2(Y15PT161P)-KAP
% A # Natural hydrolysis
CycB-Cdc2(Y15PT161P)-KAP --> CycB-Cdc2(Y15P) KAP P
% A
CycB-Cdc2(T14PY15PT161P) KAP <--> CycB-Cdc2(T14PY15PT161P)-KAP
% A # Natural hydrolysis
CycB-Cdc2(T14PY15PT161P)-KAP --> CycB-Cdc2(T14PY15P) KAP P
% A
CycA-Cdc2(T161P) GSKn-aT <--> CycA-Cdc2(T161P)-GSKn-aT
% A
CycA-Cdc2(T161P)-GSKn-aT --> CycA(P) Cdc2(T161P) GSKn ADP
% A
CycB-Cdc2(T161P) GSKn-aT <--> CycB-Cdc2(T161P)-GSKn-aT
% A
CycB-Cdc2(T161P)-GSKn-aT --> CycB(P) Cdc2(T161P) GSKn ADP
% A # Natural hydrolysis
CycB(P) --> CycB P
% A
CycB-Cdc2(T161P) Wee1 <--> CycB-Cdc2(T161P)-Wee1
% A
CycB-Cdc2(T161P)-Wee1 --> CycB-Cdc2(T161P) Wee1(P) ADP
% A
Cdc20 Apcs <--> Cdc20-Apcs
% A
Cdh1 Apcs <--> Cdh1-Apcs
% A
Secullin Cdc20-Apcs-nUb <--> Secullin{P(nUb)} Cdc20-Apcs
% A # Hershko, 1994
CycB(P) Cdh1-Apcs-nUb <--> CycB{P(nUb)} Cdh1-Apcs
% A
Wee1(P) SCF-P(nUb) <--> Wee1(P){P(nUb)} SCF
% A
Secullin{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A # Hershko, 1994
CycB{P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
Wee1(P){P(nUb)} Proteasome --> Peptides nUb Proteasome
% A
CycA-Cdc2(T161P) ATP <--> CycA-Cdc2(T161P)-aT
% A # Fujita 1998
CycA-Cdc2(T161P)-aT MCM <--> CycA-Cdc2(T161P) ADP MCM(P)
% A
CycA-Cdc2(T161P)-aT Cdc6 <--> CycA-Cdc2(T161P) ADP Cdc6(P)
% A # Fujita 1999
CycA-Cdc2(T161P)-aT Chromatin <--> CycA-Cdc2(T161P) ADP Chromatin(P)
% A # Natural hydrolysis
Chromatin(P) --> Chromatin P
% A
CycA-Cdc2(T161P)-aT Cdc25C <--> CycA-Cdc2(T161P)-aT-Cdc25C
% A
CycA-Cdc2(T161P)-aT-Cdc25C --> CycA-Cdc2(T161P) ADP Cdc25C(S/TP)
% A # Natural hydrolysis
Cdc25C(S/TP) --> Cdc25C P
% A
CycB-Cdc2(T161P) ATP <--> CycB-Cdc2(T161P)-aT
% A # Fujita 1998
CycB-Cdc2(T161P)-aT MCM <--> CycB-Cdc2(T161P) ADP MCM(P)
% A # Nagai 1995
CycB-Cdc2(T161P)-aT Cdc20 <--> CycB-Cdc2(T161P) ADP Cdc20(P)
% A
CycB-Cdc2(T161P)-aT Cdc25C <--> CycB-Cdc2(T161P)-aT-Cdc25C
% A
CycB-Cdc2(T161P)-aT-Cdc25C --> CycB-Cdc2(T161P) ADP Cdc25C(S/TP)
% A
MEN Cdc14 --> MEN Cdc14a
% A
Cdc14a Cdh1(P) <--> Cdc14a-Cdh1(P)
% A # Natural hydrolysis
Cdc14a-Cdh1(P) --> Cdc14a Cdh1 P
% A
Cdc20-Apcs Mad2 <--> Cdc20-Apcs-Mad2
% B
RsT PI3K(YP) <--> RsT-PI3K(YP)
% B
RsT-PI3K(YP) Kinasei <--> RsT-PI3K(YP)-Kinasea
% B
RsT-PI3K(YP)-Kinasea Akt <--> RsT-PI3K(YP)-Akt-Kinasea
% B
RsT-PI3K(YP)-Akt-Kinasea ATP <--> RsT-PI3K(YP)-Akt-Kinasea-aT
% B
RsT-PI3K(YP)-Akt-Kinasea-aT --> RsT-PI3K(YP)-Akt(P)-Kinasea ADP
% B
RsT-PI3K(YP)-Akt(P)-Kinasea --> RsT-PI3K(YP)-Kinasea Akt(P)
% A # Natural hydrolysis
Akt(P) --> Akt P
% A
Akt(P) ATP <--> Akt(P)-aT
% A
GSKc Akt(P)-aT --> GSKc(P) Akt(P) ADP
% A
GSKc <--> GSKn
% A
P21 CycD-Cdk4(T172P) <--> P21-CylinD-Cdk4(T172P)
% A
P21 CycD-Cdk6(T172P) <--> P21-CylinD-Cdk6(T172P)
% A
P21 CycE-Cdk2(T160P) <--> P21-CycE-Cdk2(T160P)
% A
P27 CycD-Cdk4(T172P) <--> P27-CylinD-Cdk4(T172P)
% A
P27 CycD-Cdk6(T172P) <--> P27-CylinD-Cdk6(T172P)
% A
P27 CycE-Cdk2(T160P) <--> P27-CycE-Cdk2(T160P)
% A
P16 CycD-Cdk4(T172P) <--> CycD P16-Cdk4(T172P)
% A
P16 CycD-Cdk6(T172P) <--> CycD P16-Cdk6(T172P)
% A
P15 CycD-Cdk4(T172P) <--> CycD P15-Cdk4(T172P)
% A
P15 CycD-Cdk6(T172P) <--> CycD P15-Cdk6(T172P)
% A
P18 CycD-Cdk6(T172P) <--> CycD P18-Cdk6(T172P)
% A
P14 CycD-Cdk4(T172P) <--> CycD P14-Cdk4(T172P)
% A
P14 MDM2 <--> P14-MDM2
% A
P53 MDM2 <--> P53-MDM2
% A
c_jun(g) Myc-Max --> c_jun(r)
% A
c_fos(g) Myc-Max --> c_fos(r)
% A
cdk4(g) Myc-Max --> cdk4(r)
% A
e2f(g) Myc-Max --> e2f(r)
% A
cycE(g) Myc-Max --> cycE(r)
% A
cycA(g) Myc-Max --> cycA(r)
% A
cdc2(g) Myc-Max --> cdc2(r)
% A
cdc25A(g) Myc-Max --> cdc25A(r)
% A
cycD(g) Jun-Fos --> cycD(r)
% A
mmp(g) Jun-Fos --> mmp(r)
% A
midkine(g) Jun-Fos --> midkine(r)
% B
rhamm(g) Jun-Fos --> rhamm(r)
% A
c_fos(g) Jun-Fos --> c_fos(r)
% A
egf(g) E2F-SP1 --> egf(r)
% A
TGFbeta(g) E2F-SP1 --> TGFbeta(r)
% A
cycA(g) E2F-SP1 --> cycA(r)
% A
dbf4(g) E2F-SP1 --> dbf4(r)
% A
p53(g) E2F-SP1 --> p53(r)
% A
apf(g) E2F-SP1 --> apf(r)
% A
cdc2(g) E2F-DP1 --> cdc2(r)
% A
cdc6(g) E2F-DP1 --> cdc6(r)
% A
cycB(g) E2F-DP1 --> cycB(r)
% A
cycE(g) E2F-DP1 --> cycE(r)
% A
p53(g) E2F-DP1 --> p53(r)
% A # Arata 2000
cdc45(g) E2F-DP1 --> cdc45(r)
% A
orc1(g) E2F-DP1 --> orc1(r)
% A # Ohtani 1999
mcm(g) E2F-DP1 --> mcm(r)
% A # Arata 2000
pol_a(g) E2F-DP1 --> pol_a(r)
% A # Arata 2000
pcna(g) E2F-DP1 --> pcna(r)
% A
p21(g) 4P53 --> p21(r)
% A
p27(g) 4P53 --> p27(r)
% A
14_3_3_sigma(g) 4P53 --> 14_3_3_sigma(r)
% A
cycD(g) Jun-Jun --> cycD(r)
% A
cycA(g) Jun-ATF --> cycA(r)
% A
cycD(g) Jun-ATF --> cycD(r)
% A
c_jun(g) Jun-ATF --> c_jun(r)
% A
p21(g) Jun-SP1 --> p21(r)
% A
cdk6(g) Jun-SP1 --> cdk6(r)
% A
c_fos(g) Elk-Sapla-beta_Catenin --> c_fos(r)
% A
p16(g) ETS --> p16(r)
% A
c_myc(g) NF_kappa_B --> c_myc(r)
% A # Hay 1989
c_myc(g) Jun-Fos <--> c_myc(g)-Jun-Fos
% A
c_jun(r) --> c_Jun
% A
c_fos(r) --> c_Fos
% A
cdk4(r) --> Cdk4
% A
e2f(r) --> E2F
% A
cycE(r) --> CycE
% A
cycA(r) --> CycA
% A
cdc2(r) --> Cdc2
% A
cycD(r) --> CycD
% A
mmp(r) --> MMP
% A
midkine(r) --> Midkine
% A
rhamm(r) --> RHAMM
% A
egf(r) --> EGF
% A
TGFbeta(r) --> TGF_bata
% A
dbf4(r) --> Dbf4
% A
p53(r) --> P53
% A
apf(r) --> APF
% A
cdc6(r) --> Cdc6
% A
cycB(r) --> CycB
% A
cdc45(r) --> Cdc45
% A
orc1(r) --> ORC1
% A
mcm(r) --> MCM
% A
pol_a(r) --> pol_a
% A
pcna(r) --> PCNA
% A
p27(r) --> P27
% A
cdk6(r) --> Cdk6
% A
p16(r) --> P16
% A
c_myc(r) --> c_Myc
% A
cdc25A(r) --> Cdc25A
% A
c_Myc Max <--> c_Myc-Max
% A # MacKenna 2000
Col Iab <--> Col-Iab
% A # Giancotti 1999
Col-Iab T Pa <--> Col-Iab-T-P
% A # Giancotti 1999
Col-Iab-T-P F <--> Col-Iab-T-P-F
% A # Giancotti 1999
Col-Iab-T-P-F S <--> Col-Iab-T-P(-F)-S
% A # Giancotti 1999, Kamps 1984
Col-Iab-T-P(-F)-S ATP <--> Col-Iab-T-P(-F)-S-aT
% A # Giancotti 1999, Kamps 1984
Col-Iab-T-P(-F)-S-aT --> Col-Iab-T-P(YP)(-F)-S ADP
% A # Giancotti 1999, Natural hydrolysis
Col-Iab-T-P(YP)(-F)-S --> Col-Iab-T-P(-F)-S P
% A # Giancotti 1999, Matsuda 1992
Col-Iab-T-P(YP)(-F)-S Cr1 <--> Col-Iab-T-P(YP)-Cr1(-F)-S
% A # Giancotti 1999, Matsuda 1992
Col-Iab-T-P(YP)(-F)-S Cr2 <--> Col-Iab-T-P(YP)-Cr2(-F)-S
% A # Matsuda 1992
Col-Iab-T-P(YP)-Cr2(-F)-S Ab <--> Col-Iab-T-P(YP)-Cr2-Ab(-F)-S
% A # Matsuda 1992
Col-Iab-T-P(YP)-Cr2-Ab(-F)-S ATP <--> Col-Iab-T-P(YP)-Cr2-Ab-aT(-F)-S
% A # Matsuda 1992
Col-Iab-T-P(YP)-Cr2-Ab-aT(-F)-S --> Col-Iab-T-P(YP)-Cr2(Y221P)-Ab(-F)-S ADP
% A # Matsuda 1992, Natural hydrolysis
Col-Iab-T-P(YP)-Cr2(Y221P)-Ab(-F)-S --> Col-Iab-T-P(YP)-Cr2-Ab(-F)-S P
% A # Giancotti 1999
Col-Iab-T-P(YP)-Cr1(-F)-S G2So <--> Col-Iab-T-P(YP)-Cr1-G2So(-F)-S
% A # Giancotti 1999
Col-Iab-T-P(YP)-Cr2(-F)-S G2So <--> Col-Iab-T-P(YP)-Cr2-G2So(-F)-S
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P(YP)-Cr1-G2So(-F)-S RsD <--> Col-Iab-T-P(YP)-Cr1-G2So-RsD(-F)-S
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P(YP)-Cr1-G2So-RsD(-F)-S GTP --> Col-Iab-T-P(YP)-Cr1-G2So-RsT(-F)-S GDP
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P(YP)-Cr1-G2So-RsT(-F)-S --> Col-Iab-T-P(YP)-Cr1-G2So-(-F)-S RsT
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P(YP)-Cr2-G2So(-F)-S RsD <--> Col-Iab-T-P(YP)-Cr2-G2So-RsD(-F)-S
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P(YP)-Cr2-G2So-RsD(-F)-S GTP --> Col-Iab-T-P(YP)-Cr2-G2So-RsT(-F)-S GDP
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P(YP)-Cr2-G2So-RsT(-F)-S --> Col-Iab-T-P(YP)-Cr2-G2So-(-F)-S RsT
% A # Giancotti 1999
Col-Iab-T-P-F ATP <--> Col-Iab-T-P-F-aT
% A # Giancotti 1999
Col-Iab-T-P-F-aT --> Col-Iab-T-P-Fa ADP
% A # Natural hydrolysis
Col-Iab-T-P-Fa --> Col-Iab-T-P-F P
% A
S ATP <--> S-aT
% A
Col-Iab-T-P-F S-aT <--> Col-Iab-T-P-F-S-aT
% A
Col-Iab-T-P-F-S-aT --> Col-Iab-T-P-FP S ADP
% A # Giancotti 1999
Col-Iab-T-P-FP ATP <--> Col-Iab-T-P-FP-aT
% A # Natural hydrolysis
Col-Iab-T-P-FP --> Col-Iab-T-P-F P
% A # Giancotti 1999
Col-Iab-T-P-FP-aT --> Col-Iab-T-P-F2P ADP
% A # Natural hydrolysis
Col-Iab-T-P-F2P --> Col-Iab-T-P-FP P
% A # Natural hydrolysis
Col-Iab-T-P-F2P --> Col-Iab-T-P-Fa P
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-Fa G2So <--> Col-Iab-T-P-Fa-G2So
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-FP G2So <--> Col-Iab-T-P-FP-G2So
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P G2So <--> Col-Iab-T-P-F2P-G2So
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-Fa-S G2So <--> Col-Iab-T-P-Fa(-S)-G2So
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P-S G2So <--> Col-Iab-T-P-F2P(-S)-G2So
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P-Sa-C G2So <--> Col-Iab-T-P-F2P-Sa-C-G2So
% A # Smart 1981
Col-Iab-T-P-F2P-Sa-C(Y1P) G2So <--> Col-Iab-T-P-F2P-Sa-C(Y1P)-G2So
% A # Smart 1981
Col-Iab-T-P-F2P-Sa-C(Y2P) G2So <--> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So
% A # Smart 1981
Col-Iab-T-P-F2P-Sa-C(Y3P) G2So <--> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So
% A # Smart 1981
Col-Iab-T-P-F2P-Sa-C(Y4P) G2So <--> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So
% A
UnknownSK ATP <--> UnknownK-aT
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P-S-C UnknownSK-aT <--> Col-Iab-T-P-F2P-S(-C)-UnknownSK-aT
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P-S(-C)-UnknownSK-aT --> Col-Iab-T-P-F2P-Sa-C UnknownSK ADP
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P-Sa-C ATP <--> Col-Iab-T-P-F2P-Sa(-C)-aT
% A # Giancotti 1999, Boriack-Sjodin 1998
Col-Iab-T-P-F2P-Sa(-C)-aT <--> Col-Iab-T-P-F2P-Sa-C
% A # Giancotti 1999
Col-Iab-T-P-Fa S <--> Col-Iab-T-P-Fa-S
% A # Giancotti 1999, Sakai 1994, Nakamoto 1996
Col-Iab-T-P-Fa-S C <--> Col-Iab-T-P-Fa-S-C
% A # Giancotti 1999
Col-Iab-T-P-F2P S <--> Col-Iab-T-P-F2P-S
% A # Giancotti 1999, Sakai 1994, Nakamoto 1996
Col-Iab-T-P-F2P-S C <--> Col-Iab-T-P-F2P-S-C
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-Fa-S-C ATP <--> Col-Iab-T-P-Fa-S(-aT)-C
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-Fa-S(-aT)-C --> Col-Iab-T-P-FaSa-C(YP) ADP
% A # Natural hydrolysis
Col-Iab-T-P-FaSa-C --> Col-Iab-T-P-Fa-S-C P
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa-C ATP <--> Col-Iab-T-P-FaSa(-aT)-C
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa(-aT)-C --> Col-Iab-T-P-FaSa-C(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa-C(YP) ATP <--> Col-Iab-T-P-FaSa(-aT)-C(YP)
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa(-aT)-C(YP) --> Col-Iab-T-P-FaSa-C2(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa-C2(YP) ATP <--> Col-Iab-T-P-FaSa(-aT)-C2(YP)
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa(-aT)-C2(YP) --> Col-Iab-T-P-FaSa-C3(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa-C3(YP) ATP <--> Col-Iab-T-P-FaSa(-aT)-C3(YP)
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-FaSa(-aT)-C3(YP) --> Col-Iab-T-P-FaSa-C4(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa-C ATP <--> Col-Iab-T-P-F2PSa(-aT)-C
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa(-aT)-C --> Col-Iab-T-P-F2PSa-C(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa-C(YP) ATP <--> Col-Iab-T-P-F2PSa(-aT)-C(YP)
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa(-aT)-C(YP) --> Col-Iab-T-P-F2PSa-C2(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa-C2(YP) ATP <--> Col-Iab-T-P-F2PSa(-aT)-C2(YP)
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa(-aT)-C2(YP) --> Col-Iab-T-P-F2PSa-C3(YP) ADP
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa-C3(YP) ATP <--> Col-Iab-T-P-F2PSa(-aT)-C3(YP)
% A # Giancotti 1999, Sakai 1994, Nojima 1995, Nakamoto 1996
Col-Iab-T-P-F2PSa(-aT)-C3(YP) --> Col-Iab-T-P-F2PSa-C4(YP) ADP
% A # Natural hydrolysis
Col-Iab-T-P-F2PSa-C4(YP) --> Col-Iab-T-P-F2PSa-C3(YP) P
% A # Natural hydrolysis
Col-Iab-T-P-F2PSa-C3(YP) --> Col-Iab-T-P-F2PSa-C2(YP) P
% A # Natural hydrolysis
Col-Iab-T-P-F2PSa-C2(YP) --> Col-Iab-T-P-F2PSa-C(YP) P
% A # Natural hydrolysis
Col-Iab-T-P-F2PSa-C(YP) --> Col-Iab-T-P-F2PSa-C P
% A # Giancotti 1999
Col-Iab-T-P-F2PSa-C4(YP) Cr1 <--> Col-Iab-T-P-F2P-S-C4{(YP)-Cr1}
% A # Giancotti 1999
Col-Iab-T-P-F2PSa-C4(YP) Cr2 <--> Col-Iab-T-P-F2P-S-C4{(YP)-Cr2}
% A # Matsuda 1992
Col-Iab-T-P-F2P-S-C4{(YP)-Cr2} Ab <--> Col-Iab-T-P-F2P-S-C4{(YP)-Cr2-Ab}
% A # Matsuda 1992
Col-Iab-T-P-F2P-S-C4{(YP)-Cr2-Ab} ATP <--> Col-Iab-T-P-F2P-S-C4{(YP)-Cr2-Ab-aT}
% A # Matsuda 1992
Col-Iab-T-P-F2P-S-C4{(YP)-Cr2-Ab-aT} --> Col-Iab-T-P-F2P-S-C4{(YP)-Cr2(Y221P)-Ab} ADP
% A # Natural hydrolysis
Col-Iab-T-P-F2P-S-C4{(YP)-Cr2(Y221P)-Ab} --> Col-Iab-T-P-F2P-S-C4{(YP)-Cr2-Ab} P
% A # Vuori 1996
Col-Iab-T-P-FaSa-C4{P-Cr1} So <--> Col-Iab-T-P-Fa-S-C4{P-Cr1-So}
% A # Vuori 1996
Col-Iab-T-P-F2PSa-C4{P-Cr1} So <--> Col-Iab-T-P-F2PSa-C4{P-Cr1-So}
% A # Vuori 1996
Col-Iab-T-P-FaSa-C4{P-Cr2} So <--> Col-Iab-T-P-Fa-S-C4{P-Cr2-So}
% A # Vuori 1996
Col-Iab-T-P-F2PSa-C4{P-Cr2} So <--> Col-Iab-T-P-F2PSa-C4{P-Cr2-So}
% A # Aspenstrom 1999
Col-Iab-T-P-FP-G2So 42D <--> Col-Iab-T-P-FP-G2So-42D
% A # Aspenstrom 1999
Col-Iab-T-P-FP-G2So-42D GTP --> Col-Iab-T-P-FP-G2So-42T GDP
% A # Aspenstrom 1999
Col-Iab-T-P-FP-G2So-42T --> Col-Iab-T-P-FP-G2So 42T
% A # Aspenstrom 1999
Col-Iab-T-P-F2P-G2So 42D <--> Col-Iab-T-P-F2P-G2So-42D
% A # Aspenstrom 1999
Col-Iab-T-P-F2P-G2So-42D GTP --> Col-Iab-T-P-F2P-G2So-42T GDP
% A # Aspenstrom 1999
Col-Iab-T-P-F2P-G2So-42T --> Col-Iab-T-P-F2P-G2So 42T
% A # Aspenstrom 1999
Col-Iab-T-P-F2P(-S)-G2So 42D <--> Col-Iab-T-P-F2P(-S)-G2So-42D
% A # Aspenstrom 1999
Col-Iab-T-P-F2P(-S)-G2So-42D GTP --> Col-Iab-T-P-F2P(-S)-G2So-42T GDP
% A # Aspenstrom 1999
Col-Iab-T-P-F2P(-S)-G2So-42T --> Col-Iab-T-P-F2P(-S)-G2So 42T
% A # Aspenstrom 1999
Col-Iab-T-P-F2P(-S-C)-G2So 42D <--> Col-Iab-T-P-F2P(-S-C)-G2So-42D
% A # Aspenstrom 1999
Col-Iab-T-P-F2P(-S-C)-G2So-42D GTP --> Col-Iab-T-P-F2P(-S-C)-G2So-42T GDP
% A # Aspenstrom 1999
Col-Iab-T-P-F2P(-S-C)-G2So-42T --> Col-Iab-T-P-F2P(-S-C)-G2So 42T
% A # Aspenstrom 1999
Col-Iab-T-P-F2PSa-C4{P-Cr1-So} 42D <--> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-42D
% A # Aspenstrom 1999
Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-42D GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-42T GDP
% A # Aspenstrom 1999
Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-42T --> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So 42T
% A # Aspenstrom 1999
Col-Iab-T-P-F2PSa-C4{P-Cr2-So} 42D <--> Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-42D
% A # Aspenstrom 1999
Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-42D GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-42T GDP
% A # Aspenstrom 1999
Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr2-So-42T --> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr2-So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So 42T
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So 42D <--> Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-42D
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-42D GTP --> Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-42T GDP
% A # Smart 1981, Aspenstrom 1999
Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-42T --> Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So 42T
% A # Boriack-Sjodin 1998
Col-Iab-T-P-FP-G2So RsD <--> Col-Iab-T-P-FP-G2So-RsD
% A # Boriack-Sjodin 1998
Col-Iab-T-P-FP-G2So-RsD GTP --> Col-Iab-T-P-FP-G2So-RsT GDP
% A # Boriack-Sjodin 1998
Col-Iab-T-P-FP-G2So-RsT --> Col-Iab-T-P-FP-G2So RsT
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P-G2So RsD <--> Col-Iab-T-P-F2P-G2So-RsD
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P-G2So-RsD GTP --> Col-Iab-T-P-F2P-G2So-RsT GDP
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P-G2So-RsT --> Col-Iab-T-P-F2P-G2So RsT
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P(-S)-G2So RsD <--> Col-Iab-T-P-F2P(-S)-G2So-RsD
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P(-S)-G2So-RsD GTP --> Col-Iab-T-P-F2P(-S)-G2So-RsT GDP
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P(-S)-G2So-RsT --> Col-Iab-T-P-F2P(-S)-G2So RsT
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P(-S-C)-G2So RsD <--> Col-Iab-T-P-F2P(-S-C)-G2So-RsD
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P(-S-C)-G2So-RsD GTP --> Col-Iab-T-P-F2P(-S-C)-G2So-RsT GDP
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2P(-S-C)-G2So-RsT --> Col-Iab-T-P-F2P(-S-C)-G2So RsT
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2PSa-C4{P-Cr1-So} RsD <--> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-RsD
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-RsD GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-RsT GDP
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So-RsT --> Col-Iab-T-P-F2PSa-C3{P-Cr1-So}-(P)-Cr1-So RsT
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2PSa-C4{P-Cr2-So} RsD <--> Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-RsD
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-RsD GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-RsT GDP
% A # Boriack-Sjodin 1998
Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So-RsT --> Col-Iab-T-P-F2PSa-C3{P-Cr2-So}-(P)-Cr2-So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C(YP)-G2So}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C2(YP-G2So)}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C3(YP-G2So)}-G2So RsT
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So RsD <--> Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-RsD
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-RsD GTP --> Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-RsT GDP
% A # Boriack-Sjodin 1998, Smart 1981
Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So-RsT --> Col-Iab-T-P-F2P{-S(418)-C4(YP-G2So)}-G2So RsT
% B # Aspenstrom 1999
42T MEKK1i <--> 42D MEKK1a
% B # Morrison 1997
RsT Rfi <--> RsT-Rfi
% B # Morrison 1997
RsT-Rfi S-aT <--> RsT-Rfi-S-aT
% B # Morrison 1997
RsT-Rfi-S-aT --> RsD Rf(P) S ADP
% A # Natural hydrolysis
Rf(P) --> Rfi P
% B # Schoeberl 2002, Natural hydrolysis
Rf(P) Posphatase1 --> Rfi Posphatase1 P
% A
PKC DAG <--> PKC-DAG
% A
PKC-DAG ATP <--> PKC-DAG-aT
% B # Morrison 1997
RsT-Rfi PKC-DAG-aT <--> RsT-Rfi-PKC-DAG-aT
% B # Morrison 1997
RsT-Rfi-PKC-DAG-aT --> RsD Rf(P) PKC-DAG ADP
% A
PKC-DAG-aT --> PKC-DAG(P) ADP
% A # Natural hydrolysis
PKC-DAG(P) --> PKC-DAG P
% A
PKC-DAG(P) ATP <--> PKC-DAG(P)-aT
% A
PKC-DAG(P)-aT --> PKC-DAG(PP) ADP
% A
PKC-DAG(PP) --> PKC-DAG(P)
% A
PKC-DAG(PP) UbL <--> PKC-DAG(PP)-UbL
% A
PKC-DAG(PP)-UbL nUb <--> PKC-DAG{PP-(nUb)}-UbL
% A # Natural hydrolysis
PKC-DAG{PP-(nUb)}-UbL Proteasome --> P nUb Proteasome
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-FaSa-C3{P-Cr1}-Cr1-C3G
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-FaSa-C2{P-Cr1}2{-Cr1-C3G}
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-FaSa-C{P-Cr1}3{-Cr1-C3G}
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-FaSa-C4{P-Cr1-C3G}
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-F2PSa-C3{P-Cr1}-Cr1-C3G
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-F2PSa-C2{P-Cr1}2{-Cr1-C3G}
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-F2PSa-C{P-Cr1}3{-Cr1-C3G}
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr1} C3G <--> Col-Iab-T-P-F2PSa-C4{P-Cr1-C3G}
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-FaSa-C3{P-Cr2}-Cr1-C3G
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-FaSa-C2{P-Cr2}2{-Cr2-C3G}
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-FaSa-C{P-Cr2}3{-Cr2-C3G}
% A # Tanaka 1994
Col-Iab-T-P-FaSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-FaSa-C4{P-Cr2-C3G}
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-F2PSa-C3{P-Cr2}-Cr2-C3G
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-F2PSa-C2{P-Cr2}2{-Cr2-C3G}
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-F2PSa-C{P-Cr2}3{-Cr2-C3G}
% A # Tanaka 1994
Col-Iab-T-P-F2PSa-C4{P-Cr2} C3G <--> Col-Iab-T-P-F2PSa-C4{P-Cr2-C3G}
% A
Col-Iab-T-P-F2PSa-C3{P-Cr1}{-Cr1-C3G} 42D <--> Col-Iab-T-P-F2PSa-C3{P-Cr1}C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42D
% A
Col-Iab-T-P-F2PSa-C3{P-Cr1}C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr1}C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C3{P-Cr1}C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42T --> Col-Iab-T-P-F2PSa-C3{P-Cr1}C{(P)-Cr1-C3G}-(P)-Cr1-C3G 42T
% A
Col-Iab-T-P-F2PSa-C2{P-Cr1}2{-Cr1-C3G} 42D <--> Col-Iab-T-P-F2PSa-C2{P-Cr1}2C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42D
% A
Col-Iab-T-P-F2PSa-C2{P-Cr1}2C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C2{P-Cr1}2C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C2{P-Cr1}2C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42T --> Col-Iab-T-P-F2PSa-C2{P-Cr1}2C{(P)-Cr1-C3G}-(P)-Cr1-C3G 42T
% A
Col-Iab-T-P-F2PSa-C{P-Cr1}3{-Cr1-C3G} 42D <--> Col-Iab-T-P-F2PSa-C{P-Cr1}3C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42D
% A
Col-Iab-T-P-F2PSa-C{P-Cr1}3C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C{P-Cr1}3C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C{P-Cr1}3C{(P)-Cr1-C3G}-(P)-Cr1-C3G-42T --> Col-Iab-T-P-F2PSa-C{P-Cr1}3C{(P)-Cr1-C3G}-(P)-Cr1-C3G 42T
% A
Col-Iab-T-P-F2PSa-C4{P-Cr1-C3G} 42D <--> Col-Iab-T-P-F2PSa-C3{P-Cr1-C3G}-(P)-Cr1-C3G-42D
% A
Col-Iab-T-P-F2PSa-C3{P-Cr1-C3G}-(P)-Cr1-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr1-C3G}-(P)-Cr1-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C3{P-Cr1-C3G}-(P)-Cr1-C3G-42T --> Col-Iab-T-P-F2PSa-C3{P-Cr1-C3G}-(P)-Cr1-C3G 42T
% A
Col-Iab-T-P-F2PSa-C3{P-Cr2}{-Cr2-C3G} 42D <--> Col-Iab-T-P-F2PSa-C3{P-Cr2}C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42D
% A
Col-Iab-T-P-F2PSa-C3{P-Cr2}C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr2}C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C3{P-Cr2}C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42T --> Col-Iab-T-P-F2PSa-C3{P-Cr2}C{(P)-Cr2-C3G}-(P)-Cr2-C3G 42T
% A
Col-Iab-T-P-F2PSa-C2{P-Cr2}2{-Cr2-C3G} 42D <--> Col-Iab-T-P-F2PSa-C2{P-Cr2}2C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42D
% A
Col-Iab-T-P-F2PSa-C2{P-Cr2}2C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C2{P-Cr2}2C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C2{P-Cr2}2C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42T --> Col-Iab-T-P-F2PSa-C2{P-Cr2}2C{(P)-Cr2-C3G}-(P)-Cr2-C3G 42T
% A
Col-Iab-T-P-F2PSa-C{P-Cr2}3{-Cr2-C3G} 42D <--> Col-Iab-T-P-F2PSa-C{P-Cr2}3C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42D
% A
Col-Iab-T-P-F2PSa-C{P-Cr2}3C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C{P-Cr2}3C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C{P-Cr2}3C{(P)-Cr2-C3G}-(P)-Cr2-C3G-42T --> Col-Iab-T-P-F2PSa-C{P-Cr2}3C{(P)-Cr2-C3G}-(P)-Cr2-C3G 42T
% A
Col-Iab-T-P-F2PSa-C4{P-Cr2-C3G} 42D <--> Col-Iab-T-P-F2PSa-C3{P-Cr2-C3G}-(P)-Cr2-C3G-42D
% A
Col-Iab-T-P-F2PSa-C3{P-Cr2-C3G}-(P)-Cr2-C3G-42D GTP --> Col-Iab-T-P-F2PSa-C3{P-Cr2-C3G}-(P)-Cr2-C3G-42T GDP
% A
Col-Iab-T-P-F2PSa-C3{P-Cr2-C3G}-(P)-Cr2-C3G-42T --> Col-Iab-T-P-F2PSa-C3{P-Cr2-C3G}-(P)-Cr2-C3G 42T
% A
Rf(P) ATP <--> Rf(P)-aT
% A
MEK Rf(P)-aT <--> MEK-Rf(P)-aT
% A
MEK-Rf(P)-aT --> MEK(P) Rf(P) ADP
% A # Natural hydrolysis
MEK(P) --> MEK P
% A
MEK(P) Rf(P)-aT <--> MEK(P)-Rf(P)-aT
% A
MEK(P)-Rf(P)-aT --> MEK(PP) Rf(P) ADP
% A # Natural hydrolysis
MEK(PP) --> MEK(P) P
% A
Rf(P)-aT Cdc25A <--> Rf(P)-aT-Cdc25A
% A
Rf(P)-aT-Cdc25A --> Rf(P) ADP Cdc25A(S/TP)
% A # Natural hydrolysis
Cdc25(S/TP) --> Cdc25 P
% A # Nath, 1999
Rf(P)-aT Rb-E2F <--> Rf(P)-aT-Rb-E2F
% A # Nath, 1999
Rf(P)-aT-Rb-E2F --> Rf(P) ADP Rb(P) E2F
% A
MEKK1a ATP <--> MEKK1a-aT
% A
MEKK1a-aT MKK <--> MEKK1a-aT-MKK
% A
MEKK1a-aT-MKK --> MEKK1a ADP MKK(P)
% A # Natural hydrolysis
MKK(P) --> MKK P
% A
MEKK1a-aT MKK(P) <--> MEKK1a-aT-MKK(P)
% A
MEKK1a-aT-MKK(P) <--> MEKK1a ADP MKK(PP)
% A # Natural hydrolysis
MKK(PP) --> MKK(P) P
% A
MKK(PP) ATP <--> MKK(PP)-aT
% A
MKK(PP)-aT JNK <--> MKK(PP)-aT-JNK
% A
MKK(PP)-aT-JNK --> MKK(PP) ADP JNK(P)
% A # Natural hydrolysis
JNK(P) --> JNK P
% A
MKK(PP)-aT JNK(P) <--> MKK(PP)-aT-JNK(P)
% A
MKK(PP)-aT-JNK(P) --> MKK(PP) ADP JNKc(PP)
% A # Natural hydrolysis
JNKc(PP) --> JNKc(P) P
% A
JNKc(PP) --> JNKn(PP)
% A # Natural hydrolysis
JNKn(PP) --> JNKn(P) P
% A
JNKn(PP) ATP <--> JNKn(PP)-aT
% A
JNKn(PP)-aT c_Jun <--> JNKn(PP)-aT-c_Jun
% A
JNKn(PP)-aT-c_Jun --> JNKn(PP) c_Jun(P) ADP
% A # Natural hydrolysis
c_Jun(P) --> c_Jun P
% A
JNKn(PP)-aT c_Jun(P) <--> JNKn(PP)-aT-c_Jun(P)
% A
JNKn(PP)-aT-c_Jun(P) --> JNKn(PP) c_Jun(PP) ADP
% A # Natural hydrolysis
c_Jun(PP) --> c_Jun(P) P
% A
c_Jun(PP) c_Jun(PP) <--> Jun-Jun
% A
c_Jun(PP) c_Fos <--> Jun-Fos
% A
c_Jun(PP) ATF <--> Jun-ATF
% A
c_Jun(PP) SP1(PP) <--> Jun-SP1
% A # Natural hydrolysis
JNKn(PP) MKP --> JNKn(P) MKP P
% A
JNKn(P) --> JNKc(P)
% A
C PTP <--> C-PTP
% A
JNKc(P) C-PTP <--> JNKc(P)-C-PTP
% A # Natural hydrolysis
JNKc(P) PTP --> JNKc PTP P
% A # Giancotti 1999
Col-Iab-T-P-F2P-S-C G2So <--> Col-Iab-T-P-F2P(-S-C)-G2So
% A # Smart 1981
Col-Iab-T-P-F2PSa-C(YP) G2So <--> Col-Iab-T-P-F2P{-S(418)-C(YP)}-G2So
% A # Smart 1981
Col-Iab-T-P-F2PSa-C2(YP) G2So <--> Col-Iab-T-P-F2P{-S(418)-C2(YP)}-G2So
% A # Smart 1981
Col-Iab-T-P-F2PSa-C3(YP) G2So <--> Col-Iab-T-P-F2P{-S(418)-C3(YP)}-G2So
% A # Smart 1981
Col-Iab-T-P-F2PSa-C4(YP) G2So <--> Col-Iab-T-P-F2P{-S(418)-C4(YP)}-G2So
% A
Col-Iab-T-P-FaSa-C4{P-Cr1} So <--> Col-Iab-T-P-Fa-S-C4{(P)-Cr1-So
% A
Col-Iab-T-P-FaSa-C4{P-Cr2} So <--> Col-Iab-T-P-Fa-S-C4{(P)-Cr2-So}
% A
PKC-DAG{PP-(nUb)}-UbL Proteasome --> (P) nUb Proteasome
% A
JNKn(PP)-aT P53 <--> JNKn(PP)-aT-P53
% A
JNKn(PP)-aT-P53 --> JNKn(PP) P53(P) ADP
% A
JNKn(PP)-aT P53(P) <--> JNKn(PP)-aT-P53(P)
% A
JNKn(PP)-aT-P53(P) --> JNKn(PP) P53(PP) ADP
% A
P53(PP) P53(PP) <--> 4P53
% A # Schlaepfer 1999
Fibronectin Iab <--> Fib-Iab
% A
Fib-Iab Talin Paxilin <--> Fib-Iab-T-P
% A
Fib-Iab-T-P F <--> FiITPF
% A
FiITPF ATP <--> FiITPF-aT
% A
FiITPF-aT --> FiITPFa ADP
% A
FiITPFP ATP <--> FiITPFP-aT
% A
FiITPFP-aT --> FiITPF2P ADP
% A
FiITPFa S <--> FiITPFaS
% A
FiITPF2P S <--> FiITPF2PS
% A
FiITPFaS C <--> FiITPFaSC
% A
FiITPF2PS C <--> FiITPF2PSC
% A # Kamps 1984
FiITPFaSC ATP <--> FiITPFaS-aT-C
% A
FiITPFaS-aT-C --> FiITPFaSC(YP) ADP
% A
FiITPFaSC(YP) ATP <--> FiITPFaS-aT-C(YP)
% A
FiITPFaS-aT-C(YP) --> FiITPFaSC2(YP) ADP
% A
FiITPFaSC2(YP) ATP <--> FiITPFaS-aT-C2(YP)
% A
FiITPFaS-aT-C2(YP) --> FiITPFaSC3(YP) ADP
% A
FiITPFaSC3(YP) ATP <--> FiITPFaS-aT-C3(YP)
% A
FiITPFaS-aT-C3(YP) --> FiITPFaSC4(YP) ADP
% A
FiITPF2PSC ATP <--> FiITPF2PS-aT-C
% A
FiITPF2PS-aT-C --> FiITPF2PSC(YP) ADP
% A
FiITPF2PSC(YP) ATP <--> FiITPF2PS-aT-C(YP)
% A
FiITPF2PS-aT-C(YP) --> FiITPF2PSC2(YP) ADP
% A
FiITPF2PSC2(YP) ATP <--> FiITPF2PS-aT-C2(YP)
% A
FiITPF2PS-aT-C2(YP) --> FiITPF2PSC3(YP) ADP
% A
FiITPF2PSC3(YP) ATP <--> FiITPF2PS-aT-C3(YP)
% A
FiITPF2PS-aT-C3(YP) --> FiITPF2PSC4(YP) ADP
% A
FiITPFaSC4(YP) --> FiITPFaSC3(YP)
% A
FiITPFaSC3(YP) --> FiITPFaSC2(YP)
% A
FiITPFaSC2(YP) --> FiITPFaSC(YP)
% A
FiITPFaSC(YP) --> FiITPFaSC
% A
FiITPF2PSC4(YP) --> FiITPF2PSC3(YP)
% A
FiITPF2PSC3(YP) --> FiITPF2PSC2(YP)
% A
FiITPF2PSC2(YP) --> FiITPF2PSC(YP)
% A
FiITPF2PSC(YP) --> FiITPF2PSC
% A
FiITPFaSC4(YP) G2So <--> FiITPFaSC4(YPG2So)
% A
FiITPFaSC3(YP) G2So <--> FiITPFaSC3(YPG2So)
% A
FiITPFaSC2(YP) G2So <--> FiITPFaSC2(YPG2So)
% A
FiITPFaSC(YP) G2So <--> FiITPFaSC(YPG2So)
% A
FiITPF2PSC4(YP) G2So <--> FiITPF2PSC4(YPG2So)
% A
FiITPF2PSC3(YP) G2So <--> FiITPF2PSC3(YPG2So)
% A
FiITPF2PSC2(YP) G2So <--> FiITPF2PSC2(YPG2So)
% A
FiITPF2PSC(YP) G2So <--> FiITPF2PSC(YPG2So)
% A
FiITPFaSC4(YPG2So) RsD <--> FiITPFaSC4(YPG2SoRsD)
% A
FiITPFaSC3(YPG2So) RsD <--> FiITPFaSC3(YPG2SoRsD)
% A
FiITPFaSC2(YPG2So) RsD <--> FiITPFaSC2(YPG2SoRsD)
% A
FiITPFaSC(YPG2So) RsD <--> FiITPFaSC(YPG2SoRsD)
% A
FiITPF2PSC4(YPG2So) RsD <--> FiITPF2PSC4(YPG2SoRsD)
% A
FiITPF2PSC3(YPG2So) RsD <--> FiITPF2PSC3(YPG2SoRsD)
% A
FiITPF2PSC2(YPG2So) RsD <--> FiITPF2PSC2(YPG2SoRsD)
% A
FiITPF2PSC(YPG2So) RsD <--> FiITPF2PSC(YPG2SoRsD)
% A
FiITPFaSC4(YPG2SoRsD) GTP --> FiITPFaSC4(YPG2So) RsT GDP
% A
FiITPFaSC3(YPG2SoRsD) GTP --> FiITPFaSC3(YPG2So) RsT GDP
% A
FiITPFaSC2(YPG2SoRsD) GTP --> FiITPFaSC2(YPG2So) RsT GDP
% A
FiITPFaSC(YPG2SoRsD) GTP --> FiITPFaSC(YPG2So) RsT GDP
% A
FiITPF2PSC4(YPG2SoRsD) GTP --> FiITPF2PSC4(YPG2So) RsT GDP
% A
FiITPF2PSC3(YPG2SoRsD) GTP --> FiITPF2PSC3(YPG2So) RsT GDP
% A
FiITPF2PSC2(YPG2SoRsD) GTP --> FiITPF2PSC2(YPG2So) RsT GDP
% A
FiITPF2PSC(YPG2SoRsD) GTP --> FiITPF2PSC(YPG2So) RsT GDP
% B # Smart 1981, Morrison 1997
S-aT --> S(418) ADP
% A # Natural hydrolysis
S(418) --> S P
% B # Schoeberl 2002, Natural hydrolysis
Rf(P) phosphatase1 --> Rfi phosphatase1 P
% B # Schoeberl 2002, Natural hydrolysis
MEK(PP) phosphatase2 --> MEK phosphatase2 P
% A
MEK(PP) ATP <--> MEK(PP)-aT
% A # Schlaepfer 1999
ERK2c MEK(PP)-aT <--> ERK2c-MEK(PP)-aT
% A # Schlaepfer 1999
ERK2c-MEK(PP)-aT --> ERK2c(P) MEK(PP) ADP
% A # Natural hydrolysis
ERK2c(P) --> ERK2c P
% A # Schlaepfer 1999
ERK2c(P) MEK(PP)-aT <--> ERK2c(P)-MEK(PP)-aT
% A # Schlaepfer 1999
ERK2c(P)-MEK(PP)-aT --> ERK2c(PP) MEK(PP) ADP
% A # Natural hydrolysis
ERK2c(PP) --> ERK2c(P)
% A
ERK2c(PP) --> ERK2n(PP)
% A # Natural hydrolysis
ERK2n(PP) --> ERK2n(P) P
% A # Natural hydrolysis
ERK2n(P) --> ERK2n P
% A
ERK2n(PP) ATP <--> ERK2n(PP)-aT
% A
ERK2n(PP)-aT c_Jun <--> ERK2n(PP)-aT-c_Jun
% A
ERK2n(PP)-aT-c_Jun --> ERK2n(PP) c_Jun(P) ADP
% A
ERK2n(PP)-aT c_Jun(P) <--> ERK2n(PP)-aT-c_Jun(P)
% A
ERK2n(PP)-aT-c_Jun(P) --> ERK2n(PP) c_Jun(PP) ADP
% A # Natural hydrolysis
ERK2n(PP) phospatase3 --> ERK2n phospatase3 P
% A # Natural hydrolysis
ERK2n(PP) phospatase3 --> ERK2n(P) phospatase3 P
% A
ERK2n --> ERK2c
% A
ERK2n(P) --> ERK2c(P)
% A # Natural hydrolysis
ERK2c(P) phospatase4 --> ERK2c phospatase4 P
% A
ERK1c MEK(PP)-aT <--> ERK1c-MEK(PP)-aT
% A
ERK1c-MEK(PP)-aT --> ERK1c(P) MEK(PP) ADP
% A # Natural hydrolysis
ERK1c(P) --> ERK1c P
% A
ERK1c(P) MEK(PP)-aT <--> ERK1c(P)-MEK(PP)-aT
% A
ERK1c(P)-MEK(PP)-aT --> ERK1c(PP) MEK(PP) ADP
% A # Natural hydrolysis
ERK1c(PP) --> ERK1c(P) P
% A
ERK1c(PP) --> ERK1n(PP)
% A # Natural hydrolysis
ERK1n(PP) --> ERK1n(P) P
% A # Natural hydrolysis
ERK1n(P) --> ERK1n P
% A
ERK1n(PP) ATP <--> ERK1n(PP)-aT
% A
ERK1n(PP)-aT SP1 <--> ERK1n(PP)-aT-SP1
% A
ERK1n(PP)-aT-SP1 --> ERK1n(PP) ADP SP1(P)
% A # Natural hydrolysis
SP1(P) --> SP1 P
% A
ERK1n(PP)-aT SP1 <--> ERK1n(PP)-aT-SP1(P)
% A
ERK1n(PP)-aT-SP1(P) --> ERK1n(PP) SP1(PP) ADP
% A # Natural hydrolysis
SP1(PP) --> SP1(P) P
% A
Col-Iab Talin Paxillin <--> Col-Iab-T-P
% A
Col-Iab-T-P F(925) <--> Col-Iab-T-P-FP
% A
Col-Iab-T-P-FP-aT --> Col-Iab-T-P-F2P ATP
% A # Natural hydrolysis
F2(YP) --> F(925) P
% A
Col-Iab-T-P F ATP <--> Col-Iab-T-P-F-aT
% A
Col-Iab-T-P-Fa C <--> Col-Iab-T-P-Fa-C
% A
Col-Iab-T-P-Fa-C S <--> Col-Iab-T-P-Fa-C-S
% A
Col-Iab-T-P-Fa-C-S ATP <--> Col-Iab-T-P-Fa-C-S-aT
% A # Smart 1981
Col-Iab-T-P-Fa-C-S-aT --> Col-Iab-T-P-Fa-C-S(418) ADP
% A # Natural hydrolysis
Col-Iab-T-P-Fa-C-S(418) --> Col-Iab-T-P-Fa-C-S P
% A # Smart 1981
Col-Iab-T-P-Fa-C-S(418) ATP <--> Col-Iab-T-P-Fa-C-S(418)-aT
% A # Smart 1981
Col-Iab-T-P-Fa-C-S(418)-aT --> Col-Iab-T-P-Fa-C(YP)-S(418) ADP
% A # Natural hydrolysis
Col-Iab-T-P-Fa-C(YP)-S(418) --> Col-Iab-T-P-Fa-C-S(418) P
% A # Smart 1981
Col-Iab-T-P-Fa-C(YP)-S(418) ATP <--> Col-Iab-T-P-Fa-C(YP)-S(418)-aT
% A # Smart 1981
Col-Iab-T-P-Fa-C(YP)-S(418)-aT --> Col-Iab-T-P-Fa-C2(YP)-S(418) ADP
% A # Natural hydrolysis
Col-Iab-T-P-Fa-C2(YP)-S(418) --> Col-Iab-T-P-Fa-C(YP)-S(418) P
% A # Smart 1981
Col-Iab-T-P-Fa-C2(YP)-S(418) ATP <--> Col-Iab-T-P-Fa-C2(YP)-S(418)-aT
% A # Smart 1981
Col-Iab-T-P-Fa-C2(YP)-S(418)-aT --> Col-Iab-T-P-Fa-C3(YP)-S(418) ADP
% A # Smart 1981
Col-Iab-T-P-Fa-C3(YP)-S(418) --> Col-Iab-T-P-Fa-C2(YP)-S(418)
% A # Smart 1981
Col-Iab-T-P-Fa-C3(YP)-S(418) ATP <--> Col-Iab-T-P-Fa-C3(YP)-S(418)-aT
% A # Smart 1981
Col-Iab-T-P-Fa-C3(YP)-S(418)-aT --> Col-Iab-T-P-Fa-C4(YP)-S(418) ADP
% A # Natural hydrolysis
Col-Iab-T-P-Fa-C4(YP)-S(418) --> Col-Iab-T-P-Fa-C3(YP)-S(418) P
% A
Col-Iab-T-P S <--> Col-Iab-T-P-S
% A
Col-Iab-T-P-S ATP <--> Col-Iab-T-P-S-aT
% A
Col-Iab-T-P-S-aT --> Col-Iab-T-P-S(418) ADP
% A # Natural hydrolysis
Col-Iab-T-P-S(418) --> Col-Iab-T-P-S P
% A # Smart 1981
Col-Iab-T-P-S(418) ATP <--> Col-Iab-T-P-S(418)-aT
% A # Smart 1981
Col-Iab-T-P-S(418)-aT --> Col-Iab-T-P(YP)-S(418) ADP
% A # Natural hydrolysis
Col-Iab-T-P(YP)-S(418) --> Col-Iab-T-P-S(418) P
% A
Col-Iab-T-P-FP PI3K(YP) <--> Col-Iab-T-P-FP-PI3K(YP)
% A
Col-Iab-T-P-F(397) PI3K(YP) <--> Col-Iab-T-P-Fa-PI3K(YP)
% A
Col-Iab-T-P-F2P PI3K(YP) <--> Col-Iab-T-P-F2P-PI3K(YP)
% A # Smart 1981
Col-Iab-T-P-Fa-C(YP)-S(418) PI3K(YP) <--> Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP)
% A # Smart 1981
Col-Iab-T-P-Fa-C2(YP)-S(418) PI3K(YP) <--> Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP)
% A # Smart 1981
Col-Iab-T-P-Fa-C3(YP)-S(418) PI3K(YP) <--> Col-Iab-T-P-Fa-C3(YP){-S(418)}-PI3K(YP)
% A # Smart 1981
Col-Iab-T-P-Fa-C4(YP)-S(418) PI3K(YP) <--> Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP)
% A # Smart 1981
Col-Iab-T-P(YP)-S(418) PI3K(YP) <--> Col-Iab-T-P(YP){-S(418)}-PI3K(YP)
% A # Klippel, 1994
Col-Iab-T-P-FP-PI3K(YP) ATP <--> Col-Iab-T-P-FP-PI3K(YP)-aT
% A # Klippel, 1994
Col-Iab-T-P-Fa-PI3K(YP) ATP <--> Col-Iab-T-P-Fa-PI3K(YP)-aT
% A # Klippel, 1994
Col-Iab-T-P-F2P-PI3K(YP) ATP <--> Col-Iab-T-P-F2P-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C3(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-Fa-C3(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-F2P-C(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C2(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-F2P-C2(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C3(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-F2P-C3(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C4(YP){-S(418)}-PI3K(YP) ATP <--> Col-Iab-T-P-F2P-C4(YP){-S(418)}-PI3K(YP)-aT
% A # Klippel, 1994
Col-Iab-T-P-FP-PI3K(YP)-aT PIP --> Col-Iab-T-P-FP-PI3K(YP) ADP PIP2
% A # Klippel, 1994
Col-Iab-T-P-Fa-PI3K(YP)-aT PIP --> Col-Iab-T-P-Fa-PI3K(YP) ADP PIP2
% A # Klippel, 1994
Col-Iab-T-P-F2P-PI3K(YP)-aT PIP --> Col-Iab-T-P-F2P-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-F2P-C(YP){-S(Y4P)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C2(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-F2P-C2(YP){-S(418)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C3(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-F2P-C3(YP){-S(418)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C4(YP){-S(418)}-PI3K(YP)-aT PIP --> Col-Iab-T-P-F2P-C4(YP){-S(418)}-PI3K(YP) ADP PIP2
% A # Klippel, 1994
Col-Iab-T-P-FP-PI3K(YP)-aT PIP <--> Col-Iab-T-P-FP-PI3K(YP) ADP PIP2
% A # Klippel, 1994
Col-Iab-T-P-Fa-PI3K(YP)-aT PIP <--> Col-Iab-T-P-Fa-PI3K(YP) ADP PIP2
% A # Klippel, 1994
Col-Iab-T-P-F2P-PI3K(YP)-aT PIP <--> Col-Iab-T-P-F2P-PI3K(YP) ADP PIP2
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-Fa-C(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-Fa-C2(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-Fa-C4(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-F2P-C(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C2(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-F2P-C2(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C3(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-F2P-C3(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Klippel, 1994, Smart 1981
Col-Iab-T-P-F2P-C4(YP){-S(418)}-PI3K(YP)-aT PIP2 --> Col-Iab-T-P-F2P-C4(YP){-S(418)}-PI3K(YP) ADP PIP3
% A # Natural hydrolysis
PIP3 --> PIP2 P
% A # Natural hydrolysis
PIP2 --> PIP P
% A # Tvorogov, 2002, Hong, 2006
PIP3 PLC_gamma <--> PIP3-PLC_gamma
% A # Tvorogov, 2002, Hong, 2006
PIP3-PLC_gamma Ca <--> PIP3-PLC_gamma-Ca
% A # Tvorogov, 2002
PIP3-PLC_gamma-Ca PIP2 --> PIP3-PLC_gamma-Ca IP3 DAG
% A
IP3 --> Ca
% A # Berry, 1990
PKC Ca <--> PKC-DAG
% A # Natural hydrolysis
PKC-DAG(P) --> PKC-DAG
% A # Natural hydrolysis
PKC-DAG(PP) --> PKC-DAG(P) P
% A
C-I Cave <--> C-I-Cave
% A
C-I-Cave Fyn <--> C-I-Cave-Fyn
% A
C-I-Cave-Fyn Shc <--> C-I-Cave-Fyn-Shc
% A
C-I-Cave-Fyn-Shc ATP <--> C-I-Cave-Fyn(-aT)-Shc
% A
C-I-Cave-Fyn(-aT)-Shc --> C-I-Cave-Fyn-Shc(YP) ADP
% A # Natural hydrolysis
C-I-Cave-Fyn-Shc(YP) --> C-I-Cave-Fyn-Shc P
% A
G2 So <--> G2So
% A
C-I-Cave-Fyn-Shc(YP) G2So <--> C-I-Cave-Fyn-Shc(YP)-G2So
% A
C-I-Cave-Fyn-Shc(YP)-G2So RsD <--> C-I-Cave-Fyn-Shc(YP)-G2So-RsD
% A
C-I-Cave-Fyn-Shc(YP)-G2So-RsD GTP --> C-I-Cave-Fyn-Shc(YP)-G2So-RsT GDP
% A
EGF EGFR <--> EGF-EGFR
% A
EGF-EGFR ATP <--> EGF-2(EGFR-aT)
% A
EGF-2(EGFR-aT) --> EGFRa ADP
% A # Natural hydrolysis
EGFRa --> EGF-{EGFR(YP)}EGFR P
% A
EGF-{EGFR(YP)}EGFR --> EGF-EGFR
% A
EGFRa GAP <--> EGFRGAP
% A
EGFRGAP Col-Iab-T-P-S <--> EGFRGAP-(Col-Iab-T-P)-S
% A
EGFRGAP Col-Iab-T-P-F(YP)-S <--> EGFRGAP{-Col-Iab-T-P-F(YP)}-S
% A
EGFRGAP-(Col-Iab-T-P)-S ATP <--> EGFRGAP-(Col-Iab-T-P)-S-aT
% A # Smart 1981
EGFRGAP-(Col-Iab-T-P)-S-aT --> EGFRGAP-(Col-Iab-T-P)-S(418) ADP
% A # Natural hydrolysis
EGFRGAP-(Col-Iab-T-P)-S(418) --> EGFRGAP-(Col-Iab-T-P)-S P
% A
EGFRGAP{-Col-Iab-T-P-F(YP)}-S ATP <--> EGFRGAP{-Col-Iab-T-P-F(YP)}-S-aT
% A # Smart 1981
EGFRGAP{-Col-Iab-T-P-F(YP)}-S-aT --> EGFRGAP{-Col-Iab-T-P-F(YP)}-S(418) ADP
% A # Natural hydrolysis
EGFRGAP{-Col-Iab-T-P-F(YP)}-S(418) --> EGFRGAP{-Col-Iab-T-P-F(YP)}-S P
% A # Smart 1981, Otsu 1991
EGFRGAP-S(418) PI3K <--> EGFRGAP-S(418)-PI3K
% A # Smart 1981, Otsu 1991
EGFRGAP{-Col-Iab-T-P-F(YP)}-S(418) PI3K <--> EGFRGAP{-Col-Iab-T-P-F(YP)}-S(418)-PI3K
% A
EGFRa G2So <--> EGF-2{EGFR(YP)-G2So}
% A # Smart 1981
EGFRGAP-S(418)-PI3K RsD <--> EGFRGAP-S(418)-PI3K-RsD
% A # Smart 1981
EGFRGAP-S(418)-PI3K-RsD EGF-2{EGFR(YP)-G2So} <--> EGFRGAP-S(418)-PI3K-RsD-2{G2So-EGFR(YP)}-EGF
% A # Smart 1981
EGFRGAP-S(418)-PI3K-RsD-2{G2So-EGFR(YP)}-EGF GTP --> EGFRGAP-S(418)-PI3K-RsT-2{G2So-EGFR(YP)}-EGF GDP
% A # Smart 1981
EGFRGAP-S(418)-PI3K-RsT-2{G2So-EGFR(YP)}-EGF --> EEGFRGAP-S(418)-PI3K-RsT EGF-2{EGFR(YP)-G2So}
% A # Aspenstrom 1999
EGF-2{EGFR(YP)-G2So} 42D <--> EGF-2{EGFR(YP)-G2So-42D}
% A # Aspenstrom 1999
EGF-2{EGFR(YP)-G2So-42D} GTP --> EGF-2{EGFR(YP)-G2So-42T} GDP
% A # Aspenstrom 1999
EGF-2{EGFR(YP)-G2So-42T} --> EGF-2{EGFR(YP)-G2So} 42T
% A
EGF-2{EGFR(YP)-G2So} RsD <--> EGF-2{EGFR(YP)-G2So-RsD}
% A
EGF-2{EGFR(YP)-G2So-RsD} GTP --> EGF-2{EGFR(YP)-G2So-RsT} GDP
% A
EGF-2{EGFR(YP)-G2So-RsT} --> EGF-2{EGFR(YP)-G2So} RsT
% A
EGF 2 EGFR <--> EGF-EGFR
% A
EGF-2(EGFR-aT) <--> EGFRa 2 ADP
% A
EGFRa PLC_gamma <--> EGFRa-PLC_gamma
% A # Tvorogov, 2002
EGFRa-PLC_gamma Ca <--> EGFRa-PLC_gamma-Ca
% A # Tvorogov, 2002
EGFRa-PLC_gamma-Ca PIP2 --> EGFRa-PLC_gamma-Ca IP3 DAG
% A
Ca PKC --> PKC-DAG
% A
ERK2n(PP)-aT Elk1 <--> ERK2n(PP)-aT-Elk1
% A
ERK2n(PP)-aT-Elk1 <--> ERK2n(PP) Elk1(P) ADP
% A
ERK2n(PP)-aT Elk1(P) <--> ERK2n(PP)-aT-Elk1(P)
% A
ERK2n(PP)-aT-Elk1(P) <--> ERK2n(PP) Elk1(PP) ADP
% A
Elk1(PP) Sapla <--> Elk1(PP)-Sapla
% A
Elk1(PP)-Sapla beta_Catenin <--> Elk-Sapla-beta_Catenin
% A
Midkine Proteoglycan <--> Mid-Pro
% A
Mid-Pro S <--> Mid-Pro-S
% A
Mid-Pro-S ATP <--> Mid-Pro-S-aT
% A # Smart 1981
Mid-Pro-S-aT --> Mid-Pro-S(418) ADP
% A # Natural hydrolysis
Mid-Pro-S(418) --> Mid-Pro-S P
% A # Smart 1981
Mid-pro-S(418) PI3K <--> Mid-pro-S(P)-PI3K
% A # Smart 1981
Mid-pro-S(418)-PI3K ATP <--> Mid-pro-S(418)-aT-PI3K
% A # Smart 1981
Mid-pro-S(418)-aT-PI3K --> Mid-pro-S(418)-PI3K(P) ADP
% A # Natural hydrolysis
Mid-pro-S(418)-PI3K(P) --> Mid-pro-S(418)-PI3K P
% A # Smart 1981
Mid-pro-S(418)-PI3K(P) ATP <--> Mid-pro-S(418)-PI3K(P)-aT
% A # Smart 1981
Mid-pro-S(418)-PI3K(P)-aT PIP <--> Mid-pro-S(418)-PI3K(P)-aT-PIP
% A # Smart 1981
Mid-pro-S(418)-PI3K(P)-aT-PIP --> Mid-pro-S(418)-PI3K(P) ADP PIP2
% A # Smart 1981
Mid-pro-S(418)-PI3K(P)-aT PIP2 <--> Mid-pro-S(418)-PI3K(P)-aT-PIP2
% A # Smart 1981
Mid-pro-S(418)-PI3K(P)-aT-PIP2 --> Mid-pro-S(418)-PI3K(P) ADP PIP3
% A
Hyalronan RHAMM <--> H-R
% A
H-R Tallin Paxilin Vinculin <--> H-R-T-P-V
% A
H-R-T-P-V F <--> H-R-T-P-V-F
% A
H-R-T-P-V-F S <--> H-R-T-V-P(-F)-S
% A
H-R-T-V-P(-F)-S ATP <--> H-R-T-V-P(-F)-S-aT
% A # Smart 1981
H-R-T-V-P(-F)-S-aT --> H-R-T-V-P(-F)-S(418) ADP
% A # Smart 1981
H-R-T-V-P(-F)-S(418) ATP <--> H-R-T-V-P(-F)-S(418)-aT
% A # Smart 1981
H-R-T-V-P(-F)-S(418)-aT <--> H-R-T-V-P(P)(-F)-S(418) ADP
% A # Smart 1981
H-R-T-V-P(P)(-F)-S(418) Cr1 <--> H-R-T-V-P(P)-Cr1(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)(-F)-S(418) Cr2 <--> H-R-T-V-P(P)-Cr2(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr2(-F)-S(418) Ab <--> H-R-T-V-P(P)-Cr2-Ab(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr2-Ab(-F)-S(418) ATP <--> H-R-T-V-P(P)-Cr2-Ab-aT(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr2-Ab-aT(-F)-S(418) --> H-R-T-V-P(P)-Cr2(Y221P)-Ab(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr2(Y221P)-Ab(-F)-S(418) --> H-R-T-V-P(P)-Cr2-Ab(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr1(-F)-S(418) G2So <--> H-R-T-V-P(P)-Cr1-G2So(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr2(-F)-S(418) G2So <--> H-R-T-V-P(P)-Cr2-G2So(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr1-G2So(-F)-S(418) RsD <--> H-R-T-V-P(P)-Cr1-G2So-RsD(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr1-G2So-RsD(-F)-S(418) GTP --> H-R-T-V-P(P)-Cr1-G2So-RsT(-F)-S(418) GDP
% A # Smart 1981
H-R-T-V-P(P)-Cr1-G2So-RsT(-F)-S(418) --> H-R-T-V-P(P)-Cr1-G2So-(-F)-S(418) RsT
% A # Smart 1981
H-R-T-V-P(P)-Cr2-G2So(-F)-S(418) RsD <--> H-R-T-V-P(P)-Cr2-G2So-RsD(-F)-S(418)
% A # Smart 1981
H-R-T-V-P(P)-Cr2-G2So-RsD(-F)-S(418) GTP --> H-R-T-V-P(P)-Cr2-G2So-RsT(-F)-S(418) GDP
% A # Smart 1981
H-R-T-V-P(P)-Cr2-G2So-RsT(-F)-S(418) --> H-R-T-V-P(P)-Cr2-G2So-(-F)-S(418) RsT
% A
H-R-T-P-V-F ATP <--> H-R-T-P-V-F-aT
% A
H-R-T-P-V-F-aT <--> H-R-T-P-V-F(925) ADP
% A
H-R-T-P-V-F-aT <--> H-R-T-P-V-F(397) ADP
% A
H-R-T-P-V-F(925) ATP <--> H-R-T-P-V-F(925)-aT
% A
H-R-T-P-V-F(397) ATP <--> H-R-T-P-V-F(397)-aT
% A
H-R-T-P-V-F(925)-aT <--> H-R-T-P-V-F2(YP) ADP
% A
H-R-T-P-V-F(397)-aT <--> H-R-T-P-V-F2(YP) ADP
% A
H-R-T-P-V-F2(YP) S <--> H-R-T-P-V-F2(YP)-S
% A # Smart 1981, Kamps 1984
H-R-T-P-V-F2(YP)-S ATP <--> H-R-T-P-V-F2(YP)-S(418) ADP
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418) PI3K <--> H-R-T-P-V-F2(YP)-S(418)-PI3K
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K ATP <--> H-R-T-P-V-F2(YP)-S(418)-PI3K-aT
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-aT PIP <--> H-R-T-P-V-F2(YP)-S(Y4P)-PI3K-aT-PIP
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-aT-PIP --> H-R-T-P-V-F2(YP)-S(418)-PI3K ADP PIP2
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-aT PIP2 <--> H-R-T-P-V-F2(YP)-S(418)-PI3K-aT-PIP2
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-aT-PIP2 --> H-R-T-P-V-F2(YP)-S(418)-PI3K ADP PIP3
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K Shc <--> H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc G2So <--> H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So RsD <--> H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So-RsD
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So-RsD GTP --> H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So-RsT GDP
% A # Smart 1981
H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So-RsT --> H-R-T-P-V-F2(YP)-S(418)-PI3K-Shc-G2So RsT
% A
TGFbeta TGFR_II <--> TGFbeta-TGFR_II
% A
TGFbeta-TGFR_II TGFR_I <--> TGFbeta-TGFR_II-TGFR_I
% A
TGFbeta-TGFR_II-TGFR_I ATP <--> TGFbeta-TGFR_II-TGFR_I-aT
% A
TGFbeta-TGFR_II-TGFR_I-aT --> TGFbeta-TGFR_II-TGFR_I(P)
% A # Heldin 1997
TGFbeta-TGFR_II-TGFR_I(P) Smad P <--> TGFbeta-TGFR_II-TGFR_I(P) Smad(P)
% A
Smad(P) Smad(P) <--> Smad(P)c
% A
Smad(P)c --> Smad(P)n
% A
p15(g) Smad --> p15(r)
% A
p18(g) Smad --> p18(r)
% A
p14(g) Smad --> p14(r)
% A
p21(g) Smad --> p21(r)
% A
p27(g) Smad --> p27(r)
% A
TGFbeta(g) Smad --> TGFbeta(r)
% A
egfr(g) Smad --> egfr(r)
% A
integrin(g) Smad --> integrin(r)
% A
fibronectin(g) Smad --> fibronectin(r)
% A
Col(g) Smad --> Col(r)
% A
c-fos(g) Smad --> c-fos(r)
% A
c-jun(g) Smad --> c-jun(r)
% A
c-myc(r) Smad --> Dmyc Smad
% A
cycA(r) Smad --> DcyclinA Smad
% A
cdc25A(r) Smad --> Dcdc25A Smad
% A
mmp(r) Smad --> Dmmp Smad
% A
p15(r) --> P15
% A
p18(r) --> P18
% A
p14(r) --> P14
% A
TGFbeta(r) --> TGFbeta
% A
egfr(r) --> EGFR
% A
integrin(r) --> Integrin
% A
fibronectin(r) --> Fibronectin
% A
Col(r) --> Col
% A
c-fos(r) --> c-Fos
% A
c-jun(r) --> c-Jun
% A
c-myc(r) --> c-Myc
% A
TGFbeta-TGFR_II-TGFR_I(P) Csk <--> TGFbeta-TGFR_II-TGFR_I(P)-Csk
% A
TGFbeta-TGFR_II-TGFR_I(P)-Csk ATP <--> TGFbeta-TGFR_II-TGFR_I(P)-Csk-aT
% A
TGFbeta-TGFR_II-TGFR_I(P)-Csk-aT S <--> TGFbeta-TGFR_II-TGFR_I(P)-Csk-aT-S
% A # Cooper 20018
TGFbeta-TGFR_II-TGFR_I(P)-Csk-aT-S --> TGFbeta-TGFR_II-TGFR_I(P)-Csk ADP S(529)
% B # Cooper 20018
S(529) --> DS
% A # Smart 1981, Kamps 1984
S(418) ATP <--> S(418)-aT
% B # Smart 1981, Morrison 1997
RsT-Rfi S(418)-aT <--> RsT-Rfi-S(418)-aT
% B # Morrison 1997
RsT-Rfi-S(418)-aT --> RsD Rf(P) S(418) ADP
% A
MEK Rf(P)-aT --> MEK(P) Rf(P) ADP
% A
MEK(P) Rf(P)-aT --> MEK(PP) Rf(P) ADP
% A
ERK2c MEK(PP)-aT <--> ERK2c(P) MEK(PP) ADP
% A
ERK2c(P) MEK(PP)-aT <--> ERK2c(PP) MEK(PP) ADP
% A # Natural hydrolysis
ERK2c(PP) --> ERK2c(P) P
% A
ERK2n(PP)-aT ETSi <--> ERK2n(PP) ETSa ADP
% A
p16(g) ETSa --> p16(r)
% A # Smart 1981
Col-Iab-T-P(-F)-S(418) EGFRGAP <--> Col-Iab-T-P(-F)-S(418)-EGFRGAP
% A # Smart 1981
Col-Iab-T-P(-F)-S(418)-EGFRGAP ATP <--> Col-Iab-T-P(-F-aT)-S(418)-EGFRGAP
% A # Smart 1981
Col-Iab-T-P(-F-aT)-S(418)-EGFRGAP --> Col-Iab-T-P(-F)-S(418) EGAP-EGFR(YPYP-GAP) ADP
% A # Smart 1981
Col-Iab-T-P(-F)-S(418)-EGFRGAP ATP <--> Col-Iab-T-P(-F)-S(418)(-aT)-EGFRGAP
% A # Smart 1981
Col-Iab-T-P(-F)-S(418)(-aT)-EGFRGAP --> Col-Iab-T-P(-F)-S(418) EGAP-EGFR(YPYP-GAP) ADP
% A
EGAP-EGFR(YPYP-GAP) --> EGFRGAP
% A
EGAP-EGFR(YPYP-GAP) G2So <--> EGAP-EGFR(YP-GAP)(YP)-G2So
% A
EGAP-EGFR(YP-GAP)(YP)-G2So RsD <--> EGAP-EGFR(YP-GAP)(YP)-G2So-RsD
% A
EGAP-EGFR(YP-GAP)(YP)-G2So-RsD GTP --> EGAP-EGFR(YP-GAP)(YP)-G2So-RsT GDP
% A
EGAP-EGFR(YP-GAP)(YP)-G2So-RsT <--> EGAP-EGFR(YPYP-GAP) G2So RsT
% A
EGAP-EGFR(YPYP-GAP) PI3K <--> EGAP-EGFR(YP-GAP)(YP)-PI3K
% A
EGAP-EGFR(YP-GAP)(YP)-PI3K RsT <--> EGAP-EGFR(YP-GAP)(YP)-PI3K-RsT
% A
EGAP-EGFR(YP-GAP)(YP)-PI3K-RsT ATP <--> EGAP-EGFR(YP-GAP)(YP)-PI3K-aT-RsT
% A
EGAP-EGFR(YP-GAP)(YP)-PI3K-aT-RsT PIP2 <--> EGAP-EGFR(YP-GAP)(YP)-PI3K-aD-RsT PIP3
% A
EGAP-EGFR(YP-GAP)(YP)-PI3K-aT-RsT PIP3-Akt <--> EGAP-EGFR(YP-GAP)(YP)-PI3K-aD-RsT PIP3-Akt(P)
% A
PIP3-Akt(P) ATP <--> PIP3-Akt(P)-aT
% A
PIP3-Akt(P)-aT Bad <--> PIP3-Akt(P)-aD Bad(P)
% A
Bad Bclxl-Apaf1-C9 <--> Bad-Bclxl proApaf1-C9
% A
proApaf1-C9 --> Apaf1-C9
% A
Apaf1-C9 proC3 --> Apaf1-C9 C3
% A
C3 proCAD --> C3 CAD
% A
CAD DNA --> CAD n(nucleosome)
% A # Giancotti 1999
Col-Iab-T-P Fyn <--> Col-Iab-T-P-Fyn
% A
Col-Iab-T-P-Fyn Shc <--> Col-Iab-T-P-Fyn-Shc
% A
Col-Iab-T-P-Fyn-Shc ATP <--> Col-Iab-T-P-Fyn-aT-Shc
% A
Col-Iab-T-P-Fyn-aT-Shc <--> Col-Iab-T-P-Fyn-aD-Shc(YP)
% A
Col-Iab-T-P-Fyn-aD-Shc(YP) G2So <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So RsD <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-RsD
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-RsD GTP --> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-RsT GDP
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-RsT <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So RsT
% A
EGFRa PI3K <--> EYP-EGFR(YP)-PI3K
% A
EYP-EGFR(YP)-PI3K RsT <--> EYP-EGFR(YP)-PI3K(YP)-RsT
% A
EYP-EGFR(YP)-PI3K(YP)-RsT Akt <--> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt
% B
EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt Kinasei --> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt-Kinasea
% B
EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt-Kinasea ATP <--> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt-Kinasea-aT
% B
EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt-Kinasea-aT --> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P) Kinasea ADP
% A
EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P) ATP <--> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P)-aT
% A
EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P)-aT Bad <--> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P)-aT-Bad
% A
EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P)-aT-Bad --> EYP-EGFR(YP)-PI3K(YP)(-RsT)-Akt(P) ADP Bad(P)
% A
Col-Iab-T-P-Fyn-aD-Shc(YP) G2 <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2 So <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So 42D <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-42D
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-42D GTP --> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-42T GDP
% A
Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So-42T <--> Col-Iab-T-P-Fyn-aD-Shc(YP)-G2So 42T
% A
EYP-EGFR(YP)-PI3K 42T <--> EYP-EGFR(YP)-PI3K(YP)-42T
% A
EYP-EGFR(YP)-PI3K(YP)-42T ATP <--> EYP-EGFR(YP)-PI3K(YP)-aT-42T
% A
EYP-EGFR(YP)-PI3K(YP)-aT-42T PIP2 <--> EYP-EGFR(YP)-PI3K(YP)-aD-42T PIP3
% A
EYP-EGFR(YP)-PI3K(YP)-aT-42T PIP3-Akt <--> EYP-EGFR(YP)-PI3K(YP)-aD-42T PIP3-Akt(P)
% A # Giancotti 1999
Col-Iab-T-P-F-aT <--> Col-Iab-T-P-F(P) ADP
% A # Giancotti 1999
Col-Iab-T-P-F(P) S <--> Col-Iab-T-P-F(P)-S
% A # Smart 1981
Col-Iab-T-P-F(P)-S ATP <--> Col-Iab-T-P-F(P)-S-aT
% A # Smart 1981
Col-Iab-T-P-F(P)-S-aT <--> ColIabTPS(P)F(P) ADP
% A # Giancotti 1999
ColIabTPS(P)F(P) G2 <--> ColIabTPS(P)F(P)G2
% A # Giancotti 1999
ColIabTPS(P)F(P)G2 So <--> ColIabTPS(P)F(P)G2So
% A
ColIabTPS(P)F(P)G2So RsD <--> ColIabTPS(P)F(P)G2So-RsD
% A
ColIabTPS(P)F(P)G2So-RsD GTP --> ColIabTPS(P)F(P)G2So-RsT GDP
% A
ColIabTPS(P)F(P)G2So-RsT <--> ColIabTPS(P)F(P)G2So RsT
% A # Smart 1981
Col-Iab-T-P-F(P)-S-aT <--> ColIabTP-S(418)-F(P) ADP
% A # Smart 1981
Col-Iab-T-P-S(418)-F(P) PI3K <--> Col-Iab-T-P-S(418)-F(P)-PI3K(YP)
% A # Smart 1981
Col-Iab-T-P-S(418)-F(P)-PI3K(YP) ATP <--> Col-Iab-T-P-S(418)-F(P)-PI3K(YP)TPa
% A # Smart 1981
Col-Iab-T-P-S(418)-F(P)-PI3K(YP)-aT PIP2 <--> Col-Iab-T-P-S(418)-F(P)-PI3K(YP)-aD PIP3
% A # Smart 1981
Col-Iab-T-P-S(418)-F(P)-PI3K(YP)-aT PIP3-Akt <--> Col-Iab-T-P-S(418)-F(P)-PI3K(YP)-aD PIP3-Akt(P)
% A # Kuchel, 2004
PRPP glu glu Mg --> PRA
% A # Kuchel, 2004
PRPP glu APT Mg GMP --> PRPP glu APT-GMP Mg
% A # Kuchel, 2004
PRPP glu APT Mg GDP --> PRPP glu APT-GDP Mg
% A # Kuchel, 2004
PRPP glu APT Mg GTP --> PRPP glu APT-GTP Mg
% A # Kuchel, 2004
PRPP glu APT Mg AMP --> PRPP glu APT-AMP Mg
% A # Kuchel, 2004
PRPP glu APT Mg ADP --> PRPP glu APT-aD Mg
% A # Kuchel, 2004
PRPP glu APT Mg ATP --> PRPP glu APT-aT Mg
% A # Kuchel, 2004
PRA --> ribose-5-phosphate
% A # Kuchel, 2004
NH3 HCOOH CO2 gly aspartate ribose-5-phosphate ATP --> IMP fumarate ADP AMP Ppi Pi
% A # Kuchel, 2004
IMP-Mg GTP --> adenylosuccinic_acid
% A # Kuchel, 2004
adenylosuccinic_acid --> AMP fumarate
% A # Kuchel, 2004
IMP NAD --> xanthynic_acid glu ATP GMP glutaminate AMP Ppi
% A # Kuchel, 2004
GMP P --> GDP
% A # Kuchel, 2004
AMP P --> ADP
% A # Kuchel, 2004
glu CO2 ATP carbamoyl_phosphate_synthase --> carbamoyl_phosphate
% A # Kuchel, 2004
calvamoyl_phosphate --> UMP
% A # Kuchel, 2004
UMP P --> UDP
% A # Kuchel, 2004
UDP P --> UTP
% A # Kuchel, 2004
UTP carbamoyl_phosphate_synthase --> UTP-carbamoyl_phosphate_synthase
% A # Kuchel, 2004
glu CO2 ATP --> NH2COOPO32 ADP Pi glutaminate
% A # Kuchel, 2004
UTP glu ATP --> CTP glutaminate ADP
% A # Kuchel, 2004, Natural hydrolysis
ATP --> ADP P
% A # Kuchel, 2004, Natural hydrolysis
ADP --> AMP P
% A # Kuchel, 2004, Natural hydrolysis
GTP --> GDP P
% A # Kuchel, 2004, Natural hydrolysis
GDP --> GMP P
% A # Kuchel, 2004, Natural hydrolysis
UTP --> UDP P
% A # Kuchel, 2004, Natural hydrolysis
UDP --> UMP P
% A # Kuchel, 2004, Natural hydrolysis
CTP --> CDP P
% A # Kuchel, 2004, Natural hydrolysis
CDP --> CMP P
% A # Kuchel, 2004
ADP Thio RDR NADPH H --> dADP Thio RDR NADP H2O
% A # Kuchel, 2004
GDP Thio RDR NADPH H --> dGDP Thio RDR NADP H2O
% A # Kuchel, 2004
CDP Thio RDR NADPH H --> dCDP Thio RDR NADP H2O
% A # Kuchel, 2004
dADP ATP --> dATP ADP
% A # Kuchel, 2004
dGDP ATP --> dGTP ADP
% A # Kuchel, 2004
dCDP ATP --> dCTP ADP
% A # Kuchel, 2004
UMP Thio RDR NADPH H --> dUMP Thio RDR Thio NADP H2O
% A # Kuchel, 2004
dUMP N5_N10-methylene-THF --> dTMP DHF
% A # Kuchel, 2004
DHF DHF_reductase --> THF
% A # Kuchel, 2004
THF SSHT --> N5_N10-methylene-THFglysine
% A # Kuchel, 2004
dTMP ATP --> dTTP ADP
% A
pol_a dATP dGTP dCTP dTTP --> DNA pol_a

###References###
Aspenstrom P. The Rho GTPases have multiple effects on the actin cytoskeleton. Exp Cell Res. 1999 Jan 10;246(1):20-5.

Arata Y, Fujita M, Ohtani K, Kijima S, Kato JY. Cdk2-dependent and -independent pathways in E2F-mediated S phase induction. J Biol Chem. 2000, 275, 6337-6345.

Berry N, Nishizuka Y. Protein kinase C and T cell activation. Eur J Biochem. 1990, 189, 205-214.

Booher RN, Holman PS, Fattaey A. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J Biol Chem. 1997,272, 22300-22306.

Carrano AC, Pagano M. Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol. 2001, 153, 1381-1390.

Cooper ME. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia. 2001, 44, 1957-1972.

Fujita M, Yamada C, Tsurumi T, Hanaoka F, Matsuzawa K, Inagaki M. Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase. J Biol Chem. 1998, 273, 17095-17101. 

Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T. Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. J Biol Chem. 1999, 274, 25927-25932. 

Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T. Nuclear organization of DNA replication initiation proteins in mammalian cells.
J Biol Chem. 2002, 277, 10354-10361. 

Giancotti FG, Ruoslahti E. Integrin signaling. Science. 1999, 285, 1028-1032.

Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 1997, 390, 465-471.

Hay N, Bishop JM, Levens D. Regulatory elements that modulate expression of human c-myc. Genes Dev. 1987, 1, 659-671. 

Hershko A, Ganoth D, Sudakin V, Dahan A, Cohen LH, Luca FC, Ruderman JV, Eytan E. Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2. J Biol Chem. 1994 ,269, 4940-4946. 

Hong JH, Moon SJ, Byun HM, Kim MS, Jo H, Bae YS, Lee SI, Bootman MD, Roderick HL, Shin DM, Seo JT. Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes. J Biol Chem. 2006, 281, 13057-13067.

Klippel,A., Escobedo,J.A., Hirano,M. and Williams,L.T. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell. Biol. 1994, 14, 2675-2685

Kuchel PW. Current status and challenges in connecting models of erythrocyte metabolism to experimental reality. Prog Biophys Mol Biol. 2004, 85, 325-342.

Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, Draetta GF, Gyuris J. Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 1997,14, 1999-2004.

MacKenna D, Summerour SR, Villarreal FJ. Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis. Cardiovasc Res. 2000, 46, 257-263.

Morrison DK, Cutler RE. The complexity of Raf-1 regulation. Curr Opin Cell Biol. 1997, 9, 174-179. 

Nagai Y, Kaneda S, Nomura K, Yasuda H, Seno T, Yamao F. Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2.
J Cell Sci. 1995, 108, 2145-2152. 

Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 2000, 19, 2069-2081. 

Nath N, Bian H, Reed EF, Chellappan SP. HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J Immunol. 1999, 162, 5351-5358.

Ohtani K, Iwanaga R, Nakamura M, Ikeda M, Yabuta N, Tsuruga H, Nojima H. Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene. 1999, 18, 2299-2309. 

Poon RY, Jiang W, Toyoshima H, Hunter T. Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem. 1996, 271,13283-13291.

Poterszman A, Andersen G, Busso D, Rossignol M, Egly JM, Thierry JC. Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH. Protein Expr Purif. 1997, 9, 153-158.

Russo AA, Tong L, Lee JO, Jeffrey PD, Pavletich NP. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature. 1998, 395, 237-243. 

Schlaepfer DD, Hauck CR, Sieg DJ. Signaling through focal adhesion kinase. Prog Biophys Mol Biol. 1999,71, 435-478.

Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993, 366, 704-707. 

Smart JE, Oppermann H, Czernilofsky AP, Purchio AF, Erikson RL, Bishop JM. Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src). Proc Natl Acad Sci U S A. 1981, 78, 6013-6017.

Szentirmay MN, Yang HX, Pawar SA, Vinson C, Sawadogo M. The IGF2 receptor is a USF2-specific target in nontumorigenic mammary epithelial cells but not in breast cancer cells. J Biol Chem. 2003, 278, 37231-37240.

Taules M, Rius E, Talaya D, Lopez-Girona A, Bachs O, Agell N. Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1. J Biol Chem. 1998,273, 33279-33286.

Tvorogov D, Carpenter G. EGF-dependent association of phospholipase C-gamma1 with c-Cbl. Exp Cell Res. 2002, 277, 86-94.

Vuori K, Hirai H, Aizawa S, Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.
Mol Cell Biol. 1996, 16, 2606-2613. 

Watanabe N, Broome M, Hunter T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 1995, 14,1878-1891.

Winston JT, Chu C, Harper JW. Culprits in the degradation of cyclin E apprehended. Genes Dev. 1999, Nov 1;13, 2751-2757.