{"text_format":"2","workbook":"xls","n_sheets":2,"sheets":["Donor 1","Donor 2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1904","formulas":"cached_only"}

{"sheet":"Donor 1","index":0,"n_rows":75,"n_cols":95,"rows_kept":75,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
[]
[null,"Human hepatocyte donor #1"]
[null,"Data are values for single replicate samples."]
[null,"For phosphoprotein assays, data were fold-change normalized to untreated sample mean (from this donor) at t = 0 hr."]
[null,"For LDH assays, data were fold-changed normalized to untreated sample mean (from this donor) at t = 48 hr."]
[]
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[null,"TEL","IL-6","TEL_IL-6",1,9.98011002962336,1.8747778247989846,0.5262378332628015,0.8383410918324165,1,4.563881215469613,1.2662292817679557,0.9951657458563536,0.8759208103130756,1,1.2663011262596326,1.241108476585655,0.9174570243034974,1.2123592175459397,1,5.115322724834615,1.0423743965671375,0.48989808689433223,0.36652959055962814,1,2.6912846189954625,1.2736660929432013,0.6290095446721953,0.7230480363010484,1,1.6856948195732047,0.534029247876974,0.1461582759487716,0.23100631838495914,1,1.4966175836362516,0.4060131846466638,0.5328692009118354,0.7349824410079477,1,3.2853211009174315,0.6275802752293578,0.7930045871559633,0.9549885321100917,1,113.10691823899371,4.635220125786163,1.949685534591195,3.4622641509433962,1,1.0098226466575717,0.8649386084583902,0.8553888130968622,0.8854024556616644,1,1.0238419618528611,0.5006811989100818,0.33119891008174385,0.4087193460490463,1,0.980551053484603,0.2964163515217,0.1854853232486944,0.15667206915180984,1,1.4853796788773193,0.5877468973955603,0.2558868329712588,0.3189689614702724,1,2.692755309863253,2.240325865580448,1.453302298516148,0.9601396566773349,1,7.613476836686945,13.727187646233038,8.328380907814694,4.793635938231166,1,1.0391404451266308,0.6432847275518035,0.5673062164236378,0.6768994627782041,1,1.1944734098018768,0.5969760166840459,0.41449426485922836,0.583941605839416,null,0.4896043447476628,0.3472566910584626,5.40359348909239,9.634687143025312,10.738753474165259]
[null,"TEL","Mix","TEL_Mix",1,10.161658908167583,2.665086754126111,1.015234870926788,0.7173085061362675,1,5.426565377532229,1.4538443830570902,1.1804788213627992,0.955340699815838,1,1.3396561944279788,0.9558387670420866,0.88040901007706,0.8870776526378187,1,6.032540675844807,1.861255140354014,0.5435365635615949,0.45413910244949046,1,3.039430449069003,2.010639962447191,0.8019089344390549,0.5892661555312158,1,1.940457940968927,0.6893933863785678,0.35606816393735147,0.18067823279882553,1,1.503795206703222,0.6071098515186988,0.46673033084837656,0.40280943872835934,1,2.976548165137615,1.198967889908257,0.9220183486238532,0.4168577981651376,1,110.50314465408805,5.188679245283019,2.50314465408805,1.4339622641509433,1,1.0807639836289222,1.0982264665757162,0.9154160982264665,0.859481582537517,1,4.427792915531335,1.662125340599455,0.5096730245231608,0.32833787465940056,1,4.111291193949217,0.7655321447866019,0.24581307401404648,0.21519899153610664,1,1.5028279271855571,1.0198017329637676,0.6028541463780058,0.3339825704796864,1,7.471632237416352,3.123363398312482,1.3354669770148386,1.213267384346814,1,31.89751988769303,25.112306972391202,7.7188816097332715,4.914716892840431,1,1.2478894858019953,0.7384497313891021,0.787567152724482,0.555640828856485,1,2.599582898852972,0.954118873826903,0.6256517205422315,0.7533889468196037,null,0.4896043447476628,0.3622942902346397,5.098984754926143,8.509506034199145,10.626253176416654]

{"sheet":"Donor 2","index":1,"n_rows":42,"n_cols":52,"rows_kept":42,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
[]
[null,"Human hepatocyte donor #2"]
[null,"Data are mean (above) and SEM (below) values for 3 replicate samples."]
[null,"For phosphoprotein assays, data were fold-change normalized to untreated sample mean (from this donor) at t = 0 hr."]
[null,"For LDH assays, data were fold-changed normalized to untreated sample mean (from this donor) at t = 48 hr."]
[null,"Empty entries signify data not collected."]
[]
[null,"Mean values",null,"Assay","p-MEK1","p-MEK1","p-MEK1","p-MEK1","p-MEK1","p-MEK1","p-MEK1","p-ERK/12","p-ERK/12","p-ERK/12","p-ERK/12","p-ERK/12","p-ERK/12","p-ERK/12","p-Akt","p-Akt","p-Akt","p-Akt","p-Akt","p-Akt","p-Akt","p-p70","p-p70","p-p70","p-p70","p-p70","p-p70","p-p70","p-p38","p-p38","p-p38","p-p38","p-p38","p-p38","p-p38","p-HSP27","p-HSP27","p-HSP27","p-HSP27","p-HSP27","p-HSP27","p-HSP27",null,"LDH","LDH","LDH","LDH","LDH"]
[null,null,null,"Time (hr)",0,0.33,1,4,12,24,48,0,0.33,1,4,12,24,48,0,0.33,1,4,12,24,48,0,0.33,1,4,12,24,48,0,0.33,1,4,12,24,48,0,0.33,1,4,12,24,48,null,0,0.33,4,24,48]
[null,"Drug treatment","Cytokine treatment","Sample ID","p-MEK1_0hr","p-MEK1_0.33hr","p-MEK1_1hr","p-MEK1_4hr","p-MEK1_12hr","p-MEK1_24hr","p-MEK1_48hr","p-ERK/12_0hr","p-ERK/12_0.33hr","p-ERK/12_1hr","p-ERK/12_4hr","p-ERK/12_12hr","p-ERK/12_24hr","p-ERK/12_48hr","p-Akt_0hr","p-Akt_0.33hr","p-Akt_1hr","p-Akt_4hr","p-Akt_12hr","p-Akt_24hr","p-Akt_48hr","p-p70_0hr","p-p70_0.33hr","p-p70_1hr","p-p70_4hr","p-p70_12hr","p-p70_24hr","p-p70_48hr","p-p38_0hr","p-p38_0.33hr","p-p38_1hr","p-p38_4hr","p-p38_12hr","p-p38_24hr","p-p38_48hr","p-HSP27_0hr","p-HSP27_0.33hr","p-HSP27_1hr","p-HSP27_4hr","p-HSP27_12hr","p-HSP27_24hr","p-HSP27_48hr",null,"LDH_0hr","LDH_0.33hr","LDH_4hr","LDH_24hr","LDH_48hr"]
[null,"DMSO","NoCyt","DMSO_NoCyt",1,1.2291537023639592,1.0601602452171213,0.6474450741362422,1.1249415900325768,1.0000641361260976,0.9002148863310171,1,1.2917165332741445,0.8988893028180589,0.7615651348967345,1.0211881949256225,1.298729807916802,0.8377930218121088,1,1.344402754172437,1.2845115591082854,0.49164154910486474,0.9614219859757616,0.41893210741173637,0.5121396468632892,1,1.220124731523627,0.9315172876408424,0.7419715245973318,1.1253383281777198,1.2715317416255205,0.6737693175540754,1,0.9339141351514005,1.129645673802768,0.878338953840435,1.1519746927094792,2.003699780465988,1.7220678907060711,1,1.0240277182335353,0.8742777549422538,0.9887045186345239,1.1066238897556564,1.3927813226040746,0.7320546203903819,null,0.46697692786647416,0.62874653519124,0.408750819331032,1.5262506313112394,1]
[null,"DMSO","Mix","DMSO_Mix",1,4.955511752163775,1.9098202454188111,0.6706050882287131,1.6247069425006602,1.5041577127415258,0.9054935406371635,1,3.9231325846138216,2.1205371130037878,0.6181174180984793,0.9506252288654932,1.352691780375782,1.1650318487129683,1,2.611534748200753,2.2636513460061525,0.8109508911924508,1.5856962158493528,1.5440192098040915,0.2873670902394589,1,2.3363766127433423,2.966608413230076,1.4564029016488358,1.4817389629161914,1.5115958126855604,1.3123053088403895,1,4.84486084123231,4.996877648326719,3.136680580629472,3.1288061413514385,3.1418735042088177,2.347903113150654,1,12.974017102579628,11.889239688369578,7.134829117437287,2.3504823206392373,1.1187990707987994,0.9473312147860261,null,0.46697692786647416,0.7155966235498394,0.5761937544320226,2.173586651293997,1.082331690889467]
[null,"TRO","NoCyt","TRO_NoCyt",1,1.0716468073367855,0.8824010714031578,0.5717712155717276,0.7000048407148567,0.8121140333866679,0.5442726907800394,1,0.8451387793635308,0.9111436798050327,0.7988351839000047,0.6454693848115224,0.6900198417784316,0.3600808009167478,1,1.881684906572344,3.640438886414662,0.85586958657519,0.6939162026802895,0.19706524761039917,0.15820031450698374,1,0.9713915371796926,1.3304236294796676,1.0729790870527065,1.076114106245206,0.3243915809880874,0.0853141581118024,1,1.1659229597778782,2.025016934815187,1.9413923677204088,1.5233495850947407,1.5669479935562949,1.0201780999723749,1,1.8270388862506626,2.722823939639135,6.417572025615728,3.5918292804234513,2.3338536667985506,2.9500303082239148,null,0.46697692786647416,0.3410887394910493,0.2774306606551708,0.670526067249578,1.259483297349128]
[null,"TRO","Mix","TRO_Mix",1,5.1253228327372105,1.8240253644956341,0.4890219937211675,1.0368400285757262,1.1169921584906566,0.6266462435576433,1,3.894926694819046,2.5910752439193048,0.7410067638070877,1.3782504032439282,1.272072565882781,0.5929807727372135,1,3.8657960799609583,5.055557177079226,0.9232675470686753,1.125692098624995,0.28918648090877636,0.35739811171098,1,2.523076376089086,2.3564245301279403,1.4028154132905348,1.924600900996587,0.6074486060769932,0.3541309513934274,1,4.466822534017913,5.682884966887686,3.399185945693223,4.297252799995815,2.4309715364553495,1.372127186102599,1,13.504895723503875,12.555574598800032,15.445182274678993,12.700515078839304,6.245141940105011,1.4625444753883523,null,0.46697692786647416,0.4594103442424771,0.544703043608747,4.55576117618903,7.000013914178203]
[null,"CLA","NoCyt","CLA_NoCyt",1,1.5492394972448822,1.0889173506233056,0.9988553088339207,2.12045038439283,1.14682651779339,0.5830110054112799,1,1.7936288977279733,1.7760940608792144,1.376132933679696,2.4097684234375736,1.5526813340101129,0.7261535431447041,1,0.8262824525519991,0.21309934759222587,0.2028730476208131,0.39440891413785767,0.38489013368325686,0.16165314142324538,1,1.0423870397983088,1.2114846295739015,0.46965940790618077,0.7991515613317518,0.5956244383253061,0.29505698740771935,1,1.4966545324931424,2.0427197428889357,1.8118870931385473,2.3489557682828877,3.267533486828589,3.292592259786467,1,2.5334868360707854,6.078518188944889,7.482699867172005,5.39801548657754,3.9647865309587216,3.988635166302908,null,0.46697692786647416,0.47216029818297955,0.7236995987436425,4.755753013204484,10.347314906109267]
[null,"CLA","Mix","CLA_Mix",1,6.571103523886904,2.065541688942496,1.1351949992641834,1.7733331056646495,1.894464496529088,1.2495091878051174,1,4.4188622276559935,2.688288287843095,0.8308254513061395,1.208054811297875,2.000403913865842,1.3129819286455184,1,3.8813025669492025,1.7924088248983958,0.5927063503729166,0.9384032368677698,1.136313256508549,0.41459783614794005,1,1.887197874860385,1.640871070793988,0.7050781661972355,0.8262149177571748,0.937999475041617,0.39396815188176343,1,4.779251601872238,4.856056788487449,2.823021079618312,3.6160727392165675,4.856941976246949,2.9465333111205876,1,12.475775219653455,11.70182753488365,13.486919992018203,7.511702346558784,4.876242755859766,3.509608353578375,null,0.46697692786647416,0.8137531590536131,0.9395078605117193,5.427881851073768,10.424065477411153]
[null,"CHL","NoCyt","CHL_NoCyt",1,1.245661308892507,null,0.9718744180275034,null,0.501738166166382,0.13380730930309268,1,1.05390762710954,null,1.8098727547115383,null,0.6237632203689192,0.17425934797768844,1,0.4640383815889455,null,0.3269737516741354,null,0.21856070059804733,0.09134199967810858,1,0.778629685499979,null,0.9988382921282447,null,0.17363516931296583,0.0029000013750463977,1,1.5367884901755504,null,1.9683180790037236,null,1.2133925695709709,0.09959878039123385,1,3.270018528694922,null,5.074925672688969,null,3.4472906728643964,0.3281302715070119,null,0.46697692786647416,0.3416555103499366,0.9127374097736898,8.595181398784487,5.480894548938735]
[null,"CHL","Mix","CHL_Mix",1,5.406869063864134,null,1.0426253742851772,null,1.1174411979693117,0.09065504051183951,1,3.246159272373526,null,1.1963540617750446,null,0.9125722928906462,0.11593253054208001,1,3.027821213834073,null,0.32137934950623814,null,0.7441713745770009,0.04688995637480521,1,2.02526768494919,null,1.23193440669682,null,0.4509290537868604,0.002664044156807211,1,4.09309519142875,null,4.347086505217572,null,1.7433196079327629,0.06211405752876643,1,14.615431990544508,null,12.410381427456505,null,2.150734428096173,0.09504938939118855,null,0.46697692786647416,0.2537938255584473,1.1297868162376605,9.718471649540811,7.489191894498848]
[null,"NOR","NoCyt","NOR_NoCyt",1,1.015923768610324,null,0.7669529217243601,null,0.8151022242230616,0.8019097214472868,1,0.8560695289431237,null,1.1319888661234812,null,0.9280659770600999,0.6737232618302439,1,1.2004383381806114,null,0.34835413137101456,null,0.9274402156343456,1.1338451439732515,1,0.9193497538280223,null,1.115559515104545,null,1.1235821943802449,0.7105443874272062,1,1.0195136979252304,null,1.725986031692813,null,1.1214283138672783,1.6003219090270233,1,1.6270641390115372,null,1.942496222316838,null,0.7223731767662158,0.6111607381336167,null,0.46697692786647416,0.41556127440172247,0.6481198520216445,1.7410237495756178,0.6868416185485843]
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[null,"RIL","NoCyt","RIL_NoCyt",1,0.6625018307503815,null,0.9215126933990164,null,1.1565405390818133,0.8834880870275036,1,0.6828930486460144,null,1.4577885486688578,null,0.8888492661214948,0.8515593354856887,1,1.3205954732611513,null,0.8551392888964839,null,1.5210535507191,1.203632725186758,1,0.5573755414735978,null,1.271466265752503,null,0.9734153019198564,0.5530409846552746,1,1.082584924048255,null,2.5738938391677437,null,1.0876824113154877,1.0600096620924935,1,1.1968483266690162,null,4.778953493505025,null,2.7871211901711317,1.2611594913194724,null,0.46697692786647416,0.6228581976843668,0.42809166974562457,0.400803896997406,6.553234718200787]
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[]
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[null,"CHL","NoCyt","CHL_NoCyt",0.09644686340043818,0.138731935447873,null,0.17734342997206815,null,0.16912028479636235,0.0391073181305235,0.087875215219229,0.147155653504652,null,0.34909653523758544,null,0.18481610102516904,0.07444078835224424,0.18829572621624668,0.0667120049816383,null,0.048458545186564526,null,0.05528118312638421,0.05872349558004047,0.10996084281543109,0.08878560812097559,null,0.3867396014701928,null,0.06787178599627623,0.009901526438693532,0.10595140282248745,0.19638891639623718,null,0.6419100622788716,null,0.36029347674653034,0.020970250997598153,0.13355080264028005,0.613492630436263,null,1.2745077664150988,null,0.9227921418761406,0.25780538929401803,null,0.15729593800517358,0.09062335665104061,0.593493590793928,2.9681235359958253,1.2174134944802646]
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