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["ORF","GENE","GI","d(SCP)","d(CP)","Unchar","Mito","DOMAIN ARCHITECTURE","ENZYME","PHYLETIC PROFILE","ANNOTATION"]
["YJR015W","YJR015W",6322475,152,10,1,0,"NA","NA","Dikarya","NA"]
["YLL061W","MMP1",6322967,151,8,0,0,"AA_permease","NA","cellular organisms","High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p"]
["YNL275W","BOR1",6324054,139,7,0,0,"HCO3_cotransp","NA","cellular organisms","Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1"]
["YIL159W","BNR1",6322032,137,10,0,0,"Drf_GBD~FH2","NA","Eukaryota","Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1"]
["YLR013W","GAT3",6323041,132,5,0,0,"GATA","NA","Eukaryota","Protein containing GATA family zinc finger motifs"]
["YHL030W","ECM29",6321757,126,10,0,0,"HEAT~HEAT","NA","Eukaryota","Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome"]
["YFL050C","ALR2",14318469,123,5,0,0,"CorA","NA","cellular organisms","Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition"]
["YML082W","YML082W",6323557,119,11,1,0,"Cys_Met_Meta_PP","2.5.1.48_Cystathionine gamma-synthase","cellular organisms","NA"]
["YMR018W","YMR018W",6323660,117,7,1,0,"TPR_2","NA","cellular organisms","NA"]
["YHR163W","SOL3",82795254,111,9,0,0,"NA","3.1.1.31_6-phosphogluconolactonase","cellular organisms","6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p"]
["YNL321W","VNX1",6324008,111,8,0,0,"DUF307~Na_Ca_ex~Na_Ca_ex","NA","cellular organisms","Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate"]
["YIL124W","AYR1",6322067,110,29,0,0,"adh_short~RmlD_sub_bind","1.1.1.101_Acylglycerone-phosphate reductase","cellular organisms","NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones"]
["YGL067W","NPY1",6321371,108,6,0,0,"zf-NADH-PPase~NUDIX","3.6.1.22_NAD(+) diphosphatase","cellular organisms","NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes"]
["YGL170C","SPO74",6321268,108,5,0,0,"NA","NA","Saccharomyces cerevisiae","Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation"]
["YCL051W","LRE1",10383756,107,9,0,0,"NA","NA","Saccharomycetaceae","Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes"]
["YER115C","SPR6",6320961,106,10,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation"]
["YIL011W","TIR3",6322179,106,17,0,0,"SRP1_TIP1","NA","Saccharomycetaceae","Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth"]
["YKL096W-A","CWP2",6322753,106,6,0,0,"PIR","NA","Saccharomycetaceae","Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored"]
["YDR421W","ARO80",6320629,105,8,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids"]
["YGR120C","COG2",37362655,104,4,0,0,"dDENN~COG2","NA","Saccharomycetaceae","Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YIL160C","POT1",6322031,103,24,0,0,"Thiolase_N~Thiolase_C","2.3.1.16_Acetyl-CoA C-acyltransferase","cellular organisms","3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids"]
["YMR191W","SPG5",37362682,102,8,0,0,"NA","NA","Saccharomycetaceae","Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources"]
["YER129W","SAK1",6320976,100,18,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"]
["YGR250C","YGR250C",6321689,100,7,1,0,"RRM_1~RRM_1~RRM_1~RRM_1","NA","Eukaryota","NA"]
["YPL258C","THI21",6324997,100,10,0,0,"Phos_pyr_kin~TENA_THI-4","NA","cellular organisms","Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p"]
["YCL057W","PRD1",6319793,99,10,0,0,"Peptidase_M3","3.4.24.37_Saccharolysin","cellular organisms","Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins"]
["YDR277C","MTH1",6320483,99,7,0,0,"NA","NA","Saccharomycetales","Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation"]
["YPR006C","ICL2",6325263,99,7,0,1,"ICL","4.1.3.30_Methylisocitrate lyase","cellular organisms","2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol"]
["YMR009W","ADI1",6323651,98,9,0,0,"ARD~AraC_binding~Cupin_2","NA","cellular organisms","Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions"]
["YBR018C","GAL7",6319492,97,7,0,0,"GalP_UDP_transf~GalP_UDP_tr_C","2.7.7.12_UDP-glucose--hexose-1-phosphate uridylyltransferase","cellular organisms","Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism"]
["YCL055W","KAR4",6319795,97,9,0,0,"MT-A70","NA","Eukaryota","Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone"]
["YER034W","YER034W",6320872,97,11,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKL084W","HOT13",6322766,96,4,0,0,"zf-CHY","NA","cellular organisms","Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex"]
["YNL047C","SLM2",6324281,96,11,0,0,"PH","NA","Dikarya","Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex"]
["YFL051C","YFL051C",14318468,95,6,1,0,"PA14","NA","Saccharomyces","NA"]
["YPL274W","SAM3",6324981,95,4,0,0,"AA_permease","NA","cellular organisms","High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p"]
["YCR043C","YCR043C",6319891,94,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YER050C","RSM18",83578098,94,8,0,0,"Ribosomal_S18","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein"]
["YIL101C","XBP1",6322090,94,10,0,0,"NA","NA","Saccharomycetaceae","Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate"]
["YPL029W","SUV3",6325228,93,4,0,1,"Helicase_C","NA","cellular organisms","ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs"]
["YAL067C","SEO1",6319250,92,15,0,0,"MFS_1","NA","cellular organisms","Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide"]
["YGR065C","VHT1",6321502,92,4,0,0,"MFS_1","NA","cellular organisms","High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin"]
["YDL012C","YDL012C",6320192,91,6,1,0,"NA","NA","Saccharomycetales","NA"]
["YEL047C","YEL047C",6320788,91,8,0,0,"FAD_binding_3~DAO~Pyr_redox_2~FAD_binding_2~FAD_binding_2","1.3.1.6_Fumarate reductase (NADH)","cellular organisms","NA"]
["YER124C","DSE1",6320971,91,7,0,0,"NA","NA","Saccharomycetales","Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall"]
["YER174C","GRX4",6321022,91,5,0,0,"Thioredoxin~Glutaredoxin","NA","cellular organisms","Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage"]
["YIL072W","HOP1",6322118,91,15,0,0,"HORMA","NA","Eukaryota","Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation"]
["YJL186W","MNN5",6322275,91,24,0,0,"NA","NA","cellular organisms","Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment"]
["YLR151C","PCD1",6323180,91,11,0,0,"NUDIX","NA","cellular organisms","Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids"]
["YOR328W","PDR10",6324904,91,10,0,0,"ABC_tran~ABC2_membrane~PDR_CDR~PDR_CDR~ABC_tran~ABC2_membrane","NA","cellular organisms","ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p"]
["YDL085W","NDE2",6320118,90,13,0,0,"Pyr_redox_2~Pyr_redox","1.6.5.3_NADH dehydrogenase (ubiquinone)","cellular organisms","Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain"]
["YIL055C","YIL055C",6322134,90,16,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML059C","NTE1",6323581,90,6,0,0,"cNMP_binding~cNMP_binding~Patatin","3.1.1.5_Lysophospholipase","cellular organisms","Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine"]
["YBL009W","ALK2",6319462,89,15,0,0,"NA","2.7.11.1_Non-specific serine/threonine protein kinase","Fungi/Metazoa group","Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins"]
["YPR166C","MRP2",6325424,89,6,0,0,"Ribosomal_S14","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YMR287C","DSS1",6323943,89,6,0,1,"RNB","3.1.13.1_Exoribonuclease II","cellular organisms","3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs"]
["YOL141W","PPM2",6324431,88,5,0,0,"LCM~Kelch_1","NA","Eukaryota","tRNA methyltransferase required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similar to Ppm1p carboxymethyltransferase"]
["YAL030W","SNC1",6319289,87,9,0,0,"Synaptobrevin","NA","Eukaryota","Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins"]
["YGR102C","YGR102C",6321539,87,7,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YKL170W","MRPL38",6322678,87,9,0,1,"Ribosomal_L14","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels"]
["YDR420W","HKR1",6320628,86,13,0,0,"NA","NA","Saccharomycetaceae","Serine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1"]
["YER081W","SER3",6320925,86,11,0,0,"2-Hacid_dh~2-Hacid_dh_C","1.1.1.95_Phosphoglycerate dehydrogenase","cellular organisms","3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p"]
["YLL042C","ATG10",6322986,86,8,0,0,"Autophagy_act_C","NA","Saccharomycetaceae","E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy"]
["YOR385W","YOR385W",6324961,86,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YIL001W","YIL001W",6322190,85,12,1,0,"Ank~BTB~BTB","NA","Eukaryota","NA"]
["YDR115W","YDR115W",6320319,85,7,1,1,"Ribosomal_L34","NA","cellular organisms","NA"]
["YHR188C","GPI16",6321982,84,3,0,0,"Gpi16","NA","Eukaryota","Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog"]
["YPL207W","TYW1",6325049,84,9,0,0,"Flavodoxin_1~Radical_SAM~Wyosine_form","NA","cellular organisms","Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions"]
["YDL239C","ADY3",6319962,83,6,0,0,"NA","NA","Saccharomycetaceae","Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p"]
["YOR093C","YOR093C",6324667,83,12,1,0,"DMAP_binding~AMP-binding~AMP-binding~AMP-binding","NA","cellular organisms","NA"]
["YNL005C","MRP7",6324323,83,9,0,1,"Ribosomal_L27","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit"]
["YNL073W","MSK1",6324256,83,6,0,1,"tRNA_anti~tRNA-synt_2~tRNA-synt_2d~tRNA-synt_2","6.1.1.6_Lysine--tRNA ligase","cellular organisms","Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria"]
["YCR019W","MAK32",6319865,82,17,0,0,"PfkB","NA","Eukaryota","Protein necessary for structural stability of L-A double-stranded RNA-containing particles"]
["YEL025C","YEL025C",6320810,82,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML061C","PIF1",6323579,82,6,0,0,"NA","NA","cellular organisms","DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA"]
["YMR193W","MRPL24",6323847,82,7,0,0,"Ribosomal_L28","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YNL160W","YGP1",6324169,82,6,0,0,"NA","NA","cellular organisms","Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p"]
["YPL005W","AEP3",6325252,82,6,0,1,"NA","NA","Eukaryota","Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex"]
["YBR228W","SLX1",6319705,81,6,0,0,"GIY-YIG","NA","Eukaryota","Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p"]
["YCL033C","YCL033C",6319816,81,10,0,0,"SelR","NA","cellular organisms","NA"]
["YJR150C","DAN1",6322610,81,4,0,0,"SRP1_TIP1","NA","Saccharomycetaceae","Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"]
["YLR446W","YLR446W",6323479,81,7,1,0,"NA","NA","Eukaryota","NA"]
["YCR003W","MRPL32",6319848,81,8,0,1,"NA","NA","Fungi/Metazoa group","Mitochondrial ribosomal protein of the large subunit"]
["YER158C","YER158C",6321006,80,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YHR127W","YHR127W",6321919,80,10,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR228W","MTF1",6323884,80,12,0,0,"RrnaAD","NA","Dikarya","Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p"]
["YOR205C","LRC5",6324779,80,10,1,1,"MMR_HSR1","NA","cellular organisms","Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media"]
["YDR143C","SAN1",6320347,79,8,0,0,"zf-C3HC4","NA","Saccharomycetales","Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins"]
["YJL058C","BIT61",6322403,79,6,0,0,"HbrB","NA","Ascomycota","Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity"]
["YJR153W","PGU1",6322613,79,7,0,0,"Glyco_hydro_28","3.2.1.15_Polygalacturonase","cellular organisms","Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins"]
["YLR012C","YLR012C",37362676,79,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOL095C","HMI1",6324477,79,10,0,0,"UvrD-helicase","NA","cellular organisms","Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD"]
["YER154W","OXA1",6321002,79,5,0,1,"60KD_IMP~60KD_IMP","NA","cellular organisms","Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals"]
["YIL092W","YIL092W",6322099,78,14,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YML078W","CPR3",6323562,78,15,0,1,"Pro_isomerase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria"]
["YBR264C","YPT10",37362623,77,14,0,0,"Miro~Ras","NA","cellular organisms","GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles"]
["YER060W","FCY21",6320902,77,10,0,0,"Transp_cyt_pur","NA","cellular organisms","Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function"]
["YGR026W","YGR026W",6321463,77,6,1,0,"NA","NA","Saccharomycetales","NA"]
["YMR042W","ARG80",6323685,77,10,0,0,"SRF-TF","NA","Eukaryota","Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p"]
["YPR054W","SMK1",6325311,77,8,0,0,"Pkinase~Pkinase_Tyr","2.7.11.24_Mitogen-activated protein kinase","cellular organisms","Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p"]
["YBR117C","TKL2",6319593,76,5,0,0,"Transketolase_N~Transket_pyr~Transketolase_C","2.2.1.1_Transketolase","cellular organisms","Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids"]
["YBR204C","YBR204C",6319681,76,14,1,0,"Abhydrolase_1~DUF2305~LACT~DUF1234","NA","Eukaryota","NA"]
["YER149C","PEA2",6320997,76,14,0,0,"NA","NA","Saccharomycetales","Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth"]
["YER183C","FAU1",6321031,76,6,0,0,"5-FTHF_cyc-lig","6.3.3.2_5-formyltetrahydrofolate cyclo-ligase","cellular organisms","5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis"]
["YLR260W","LCB5",6323289,76,11,0,0,"DAGK_cat","2.7.1.91_Sphinganine kinase","Eukaryota","Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules"]
["YNL193W","YNL193W",6324136,76,8,1,0,"NA","NA","Ascomycota","NA"]
["YHR198C","AIM18",6321992,76,8,1,1,"Chalcone","NA","Dikarya","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YKR085C","MRPL20",6322938,76,8,0,1,"NA","NA","Ascomycota","Mitochondrial ribosomal protein of the large subunit"]
["YBR040W","FIG1",6319514,75,12,0,0,"NA","NA","Saccharomycetales","Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating"]
["YDL021W","GPM2",6320183,75,28,0,0,"PGAM","5.4.2.1_Phosphoglycerate mutase","cellular organisms","Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event"]
["YLL004W","ORC3",6323025,75,7,0,0,"NA","NA","Ascomycota","Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"]
["YMR087W","YMR087W",6323734,75,9,0,0,"NA","NA","cellular organisms","NA"]
["YMR158W","MRPS8",6323808,75,7,0,0,"NA","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YMR175W","SIP18",6323829,75,7,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function whose expression is induced by osmotic stress"]
["YPL054W","LEE1",6325203,75,7,0,0,"zf-CCCH~zf-CCCH","NA","Eukaryota","Zinc-finger protein of unknown function"]
["YDR229W","IVY1",6320435,74,10,0,0,"NA","NA","Dikarya","Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase"]
["YER028C","MIG3",6320866,74,9,0,0,"zf-C2H2","NA","Fungi/Metazoa group","Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes"]
["YOR347C","PYK2",6324923,74,6,0,0,"PK~PK_C","NA","cellular organisms","Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux"]
["YGL064C","MRH4",6321374,74,8,0,1,"ResIII~DEAD~Helicase_C","NA","cellular organisms","Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function"]
["YHR199C","AIM46",6321993,74,10,1,1,"Chalcone","NA","Ascomycota","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YJR062C","NTA1",6322522,74,5,0,1,"CN_hydrolase","NA","cellular organisms","Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation"]
["YER128W","YER128W",6320975,73,9,1,0,"DUF1742~DUF1252","NA","Ascomycota","NA"]
["YGR127W","YGR127W",6321566,73,3,1,0,"DUF833","NA","cellular organisms","NA"]
["YKR080W","MTD1",6322933,73,10,0,0,"THF_DHG_CYH~THF_DHG_CYH_C","1.5.1.15_Methylenetetrahydrofolate dehydrogenase (NAD(+))","cellular organisms","NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline"]
["YLL033W","IRC19",6322995,73,8,0,0,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci"]
["YMR261C","TPS3",6323917,73,10,0,0,"Glyco_transf_20~Trehalose_PPase","NA","cellular organisms","Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway"]
["YNR034W","SOL1",6324362,73,10,0,0,"NA","3.1.1.31_6-phosphogluconolactonase","cellular organisms","Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p"]
["YDR194C","MSS116",6320400,73,8,0,1,"DEAD~Helicase_C","NA","cellular organisms","DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing"]
["YDR483W","KRE2",6320691,72,16,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation"]
["YIL007C","NAS2",6322184,72,16,0,0,"PDZ","NA","Eukaryota","Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p"]
["YMR310C","YMR310C",6323970,72,11,1,0,"DUF171","NA","cellular organisms","NA"]
["YNL339C","YRF1-6",6323990,72,12,0,0,"DEAD~Helicase_C","NA","Saccharomycetales","Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"]
["YPL244C","HUT1",6325012,72,5,0,0,"UAA~DUF6","NA","Eukaryota","Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1"]
["YOL033W","MSE1",6324540,72,9,0,1,"tRNA-synt_1c","6.1.1.17_Glutamate--tRNA ligase","cellular organisms","Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene"]
["YDR528W","HLR1",6320737,71,8,0,0,"NA","NA","Saccharomycetaceae","Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A"]
["YKL026C","GPX1",6322826,71,7,0,0,"GSHPx","1.11.1.9_Glutathione peroxidase","cellular organisms","Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress"]
["YMR171C","EAR1",6323823,71,10,0,0,"SPRY","NA","Eukaryota","Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene"]
["YBR263W","SHM1",37362622,71,5,0,1,"SHMT","2.1.2.1_Glycine hydroxymethyltransferase","cellular organisms","Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine"]
["YDR079W","PET100",6320284,71,5,0,1,"NA","NA","Ascomycota","Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme"]
["YMR056C","AAC1",6323701,71,6,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator"]
["YDL063C","YDL063C",6320141,70,3,1,0,"NA","NA","Dikarya","NA"]
["YFL036W","RPO41",14318482,70,9,0,0,"RNA_pol","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition"]
["YDR538W","PAD1",6320746,70,5,0,1,"Flavoprotein","NA","cellular organisms","Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX"]
["YGR150C","DMR1",6321589,70,10,0,1,"PPR","NA","Saccharomycetales","Protein of unknown function, contains PPR motifs; mutant has growth defects on both non-fermentable carbon sources and rich medium; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YJL096W","MRPL49",37362666,70,8,0,1,"NA","NA","Fungi/Metazoa group","Mitochondrial ribosomal protein of the large subunit"]
["YJR113C","RSM7",6322574,70,12,0,1,"Ribosomal_S7~Ribosomal_S7","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein"]
["YER130C","YER130C",6320977,69,13,1,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","NA"]
["YGR030C","POP6",6321467,69,5,0,0,"NA","3.1.26.5_Ribonuclease P","Saccharomycetaceae","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"]
["YLL021W","SPA2",6323007,69,14,0,0,"GIT_SHD","NA","Saccharomycetaceae","Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate"]
["YNR067C","DSE4",6324395,69,5,0,0,"DUF270~Glyco_hydro_81","3.2.1.6_Endo-1,3(4)-beta-glucanase","cellular organisms","Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother"]
["YPL173W","MRPL40",6325084,69,11,0,0,"KOW","NA","Ascomycota","Mitochondrial ribosomal protein of the large subunit"]
["YDR175C","RSM24",6320380,69,5,0,1,"MRP-S28","NA","Dikarya","Mitochondrial ribosomal protein of the small subunit"]
["YGR138C","TPO2",6321577,68,4,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily"]
["YKL038W","RGT1",6322813,68,7,0,0,"Zn_clus","NA","Saccharomycetaceae","Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor"]
["YNL023C","FAP1",6324305,68,13,0,0,"zf-NF-X1~zf-NF-X1~zf-NF-X1~zf-NF-X1~zf-NF-X1~R3H","NA","Eukaryota","Protein that binds to Fpr1p (FKBP12), conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; has similarity to putative transcription factors, including D. melanogaster shuttle craft and human NFX1"]
["YOL128C","YGK3",6324444,68,8,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation"]
["YPL148C","PPT2",37362701,68,10,0,0,"ACPS","2.7.8.7_Holo-[acyl-carrier-protein] synthase","Saccharomycetaceae","Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation"]
["YDL181W","INH1",6320020,68,5,0,1,"IATP~Rho_Binding","NA","Dikarya","Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures"]
["YPL222W","FMP40",6325034,68,7,1,1,"UPF0061","NA","cellular organisms","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YNL318C","HXT14",6324011,67,7,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YBL085W","BOI1",6319386,67,13,0,0,"SH3_1~SH3_2~SAM_2~PH","NA","Ascomycota","Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"]
["YEL012W","UBC8",6579192,67,12,0,0,"UQ_con","6.3.2.19_Ubiquitin--protein ligase","Eukaryota","Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro"]
["YGR213C","RTA1",6321652,67,6,0,0,"RTA1","NA","Eukaryota","Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions"]
["YGR230W","BNS1",6321669,67,8,0,0,"Spo12","NA","Saccharomycetaceae","Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis"]
["YIL165C","YIL165C",6322026,67,13,1,0,"NA","NA","cellular organisms","NA"]
["YLR069C","MEF1",6323098,67,10,0,1,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~EFG_IV~EFG_C","NA","cellular organisms","Mitochondrial elongation factor involved in translational elongation"]
["YLR132C","YLR132C",6323161,67,9,1,1,"HVSL","NA","Ascomycota","NA"]
["YCL032W","STE50",6319817,66,15,0,0,"Ste50p-SAM~RA","NA","Ascomycota","Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction"]
["YGR130C","YGR130C",6321569,66,6,1,0,"Vitellogenin_N","NA","Saccharomycetaceae","NA"]
["YGR287C","YGR287C",6321726,66,7,0,0,"Alpha-amylase","NA","cellular organisms","NA"]
["YKR105C","YKR105C",6322958,66,5,1,0,"MFS_1~Sugar_tr~TRI12~Sugar_tr~MFS_1","NA","cellular organisms","Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny"]
["YML060W","OGG1",6323580,66,5,0,0,"OGG_N~HhH-GPD","4.2.99.18_DNA-(apurinic or apyrimidinic site) lyase","cellular organisms","Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA"]
["YNR037C","RSM19",6324365,66,14,0,0,"Ribosomal_S19","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein"]
["YPL201C","YIG1",6325055,66,14,0,0,"NA","NA","Saccharomycetaceae","Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol"]
["YBR268W","MRPL37",6319745,66,11,0,1,"Ribosomal_L37","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit"]
["YKL138C","MRPL31",6322711,66,6,0,1,"L31","NA","Dikarya","Mitochondrial ribosomal protein of the large subunit"]
["YNR052C","POP2",6324380,66,26,0,1,"CAF1","3.1.13.4_Poly(A)-specific ribonuclease","Eukaryota","RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation"]
["YLR004C","THI73",6323032,65,8,0,0,"MFS_1","NA","cellular organisms","Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs"]
["YBL032W","HEK2",6319439,65,14,0,0,"KH_1~KH_1~KH_1","NA","Eukaryota","RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length"]
["YDR009W","GAL3",6320212,65,5,0,0,"GalKase_gal_bdg~GHMP_kinases_N~GHMP_kinases_C","NA","cellular organisms","Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity"]
["YDR051C","YDR051C",6320256,65,7,0,0,"PGAM","NA","cellular organisms","NA"]
["YDR524C","AGE1",6320732,65,15,0,0,"ArfGap","NA","Eukaryota","ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif"]
["YJL037W","IRC18",6322423,65,7,0,0,"NA","NA","Saccharomyces cerevisiae","Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci"]
["YKL067W","YNK1",6322783,65,4,0,0,"NDK","2.7.4.6_Nucleoside-diphosphate kinase","cellular organisms","Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate"]
["YOL131W","YOL131W",6324441,65,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YBR275C","RIF1",6319752,64,4,0,0,"NA","NA","Saccharomycetales","Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation"]
["YCR069W","CPR4",6319914,64,14,0,0,"Pro_isomerase~Pro_isomerase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway"]
["YDR169C","STB3",6320373,64,9,0,0,"Stb3","NA","Saccharomycetaceae","Protein that binds Sin3p in a two-hybrid assay"]
["YDR492W","IZH1",6320699,64,15,0,0,"HlyIII","NA","cellular organisms","Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc"]
["YER163C","YER163C",6321011,64,6,1,0,"ChaC","NA","cellular organisms","NA"]
["YGL141W","HUL5",6321297,64,3,0,0,"HECT","NA","Eukaryota","Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD"]
["YIL050W","PCL7",6322139,64,21,0,0,"Cyclin","NA","cellular organisms","Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated"]
["YKL201C","MNN4",6322648,64,10,0,0,"LicD","NA","Saccharomycetales","Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases"]
["YLR313C","SPH1",42742288,64,8,0,0,"GIT_SHD","NA","Saccharomycetaceae","Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p"]
["YMR222C","FSH2",6323878,64,9,0,0,"FSH1~FSH1","NA","Eukaryota","Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p"]
["YDR065W","YDR065W",6320270,64,11,1,1,"Complex1_LYR","NA","Saccharomycetaceae","NA"]
["YGR171C","MSM1",6321610,64,7,0,1,"tRNA-synt_1g~tRNA-synt_1g~tRNA-synt_1e~tRNA-synt_1","6.1.1.10_Methionine--tRNA ligase","cellular organisms","Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p"]
["YJR149W","YJR149W",6322609,63,14,1,0,"NPD~NPD","1.13.11.32_2-nitropropane dioxygenase","cellular organisms","NA"]
["YNL301C","RPL18B",6324028,63,7,0,0,"Ribosomal_L18e~L15","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein"]
["YOR034C","AKR2",6324608,63,10,0,0,"Ank~Ank~Ank~zf-DHHC","NA","cellular organisms","Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p"]
["YBR163W","DEM1",6319640,63,9,0,1,"Morph_protein1~Morph_protein1","NA","Saccharomycetales","Protein of unknown function, shows similarity to RNA-processing protein Pta1p"]
["YGL129C","RSM23",6321309,63,3,0,1,"DAP3","NA","Dikarya","Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p"]
["YAL018C","YAL018C",6319301,62,10,1,0,"NA","NA","Ascomycota","NA"]
["YDL113C","ATG20",6320090,62,5,0,0,"PX","NA","Eukaryota","Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate"]
["YDL133W","YDL133W",6320069,62,30,1,0,"NA","NA","Dikarya","NA"]
["YHR122W","YHR122W",6321914,62,10,0,0,"DUF59","NA","Eukaryota","NA"]
["YHR146W","CRP1",6321940,62,6,0,0,"NA","NA","Saccharomycetaceae","Protein that binds to cruciform DNA structures"]
["YIR013C","GAT4",6322203,62,9,0,0,"GATA","NA","Eukaryota","Protein containing GATA family zinc finger motifs"]
["YML002W","YML002W",6323641,62,10,1,0,"VPS9","NA","Eukaryota","NA"]
["YMR006C","PLB2",6323648,62,4,0,0,"PLA2_B","3.1.1.5_Lysophospholipase","Fungi/Metazoa group","Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine"]
["YNL086W","YNL086W",6324243,62,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBL090W","MRP21",6319381,62,12,0,1,"NA","NA","Ascomycota","Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences"]
["YBR270C","BIT2",6319747,61,17,1,0,"HbrB","NA","Saccharomycetaceae","Hypothetical protein"]
["YJL028W","YJL028W",6322432,61,6,0,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR082C","SRL2",6323111,61,6,0,0,"NA","NA","Saccharomyces","Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation"]
["YDL044C","MTF2",6320160,61,8,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription"]
["YML116W","ATR1",6323520,60,4,0,0,"MFS_1~MFS_1","NA","cellular organisms","Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide"]
["YBL004W","UTP20",14270688,60,6,0,0,"DRIM","NA","Eukaryota","Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA"]
["YHR044C","DOG1",6321834,60,8,0,0,"Hydrolase","3.1.3.68_2-deoxyglucose-6-phosphatase","cellular organisms","2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified"]
["YLR453C","RIF2",6323486,60,12,0,0,"NA","NA","Saccharomyces cerevisiae","Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation"]
["YOL092W","YOL092W",6324480,60,10,1,0,"PQ-loop~PQ-loop","NA","Eukaryota","NA"]
["YOR262W","YOR262W",6324836,60,7,0,0,"ATP_bind_1","NA","cellular organisms","NA"]
["YPR017C","DSS4",6325274,60,7,0,0,"Mss4","NA","Saccharomycetales","Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol"]
["YDR377W","ATP17",6320585,60,4,0,1,"F1F0-ATPsyn_F","NA","Dikarya","Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YNL177C","MRPL22",6324152,60,8,0,1,"NA","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YGR224W","AZR1",6321663,59,7,0,0,"MFS_1~MFS_1","NA","cellular organisms","Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole"]
["YDR351W","SBE2",6320558,59,13,0,0,"NA","NA","Saccharomycetaceae","Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth"]
["YDR368W","YPR1",6320576,59,4,0,0,"Aldo_ket_red","NA","cellular organisms","2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism"]
["YGR263C","SAY1",6321702,59,9,0,0,"Abhydrolase_3~DUF2424","NA","cellular organisms","Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum"]
["YHR073W","OSH3",6321864,59,23,0,0,"PH~Oxysterol_BP","NA","Eukaryota","Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"]
["YHR075C","PPE1",6321866,59,10,0,0,"Thioesterase~Abhydrolase_1","NA","cellular organisms","Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein"]
["YIL146C","ECM37",6322045,59,12,0,0,"NA","NA","Saccharomycetaceae","Non-essential protein of unknown function"]
["YKL069W","YKL069W",6322781,59,10,0,0,"GAF","NA","cellular organisms","NA"]
["YMR017W","SPO20",6323659,59,4,0,0,"NA","NA","Dikarya","Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog"]
["YOL052C","SPE2",6324521,59,8,0,0,"SAM_decarbox","4.1.1.50_Adenosylmethionine decarboxylase","cellular organisms","S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically"]
["YOR172W","YRM1",6324746,59,12,0,0,"Zn_clus","NA","Saccharomycetales","Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes"]
["YOR177C","MPC54",6324751,59,8,0,0,"NA","NA","Saccharomyces cerevisiae","Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate"]
["YMR089C","YTA12",6323736,59,12,0,1,"FtsH_ext~AAA~Mg_chelatase~Peptidase_M41","NA","cellular organisms","Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"]
["YBR046C","ZTA1",6319520,58,8,0,0,"ADH_N~ADH_zinc_N","1.6.5.5_NADPH:quinone reductase","cellular organisms","Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity"]
["YIR036C","IRC24",6322227,58,6,1,0,"adh_short~KR","NA","cellular organisms","Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci"]
["YJL025W","RRN7",6322435,58,8,0,0,"NA","NA","Ascomycota","Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein"]
["YLR263W","RED1",6323293,58,4,0,0,"Red1","NA","Saccharomycetaceae","Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity"]
["YPR009W","SUT2",6325266,58,3,0,0,"Zn_clus","NA","Saccharomycetales","Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p"]
["YDR268W","MSW1",6320474,58,9,0,1,"tRNA-synt_1b","6.1.1.2_Tryptophan--tRNA ligase","cellular organisms","Mitochondrial tryptophanyl-tRNA synthetase"]
["YJL043W","YJL043W",6322418,58,7,1,1,"NA","NA","Saccharomyces cerevisiae","NA"]
["YBR108W","AIM3",50234882,57,8,1,0,"NA","NA","Saccharomycetaceae","Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YDR071C","PAA1",6320276,57,22,0,0,"Acetyltransf_1","NA","cellular organisms","Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication"]
["YDR326C","YSP2",6320533,57,16,0,0,"GRAM","NA","Eukaryota","Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification"]
["YER184C","YER184C",6321032,57,3,1,0,"Zn_clus~Fungal_trans","NA","Saccharomycetaceae","NA"]
["YGR019W","UGA1",6321456,57,5,0,0,"Aminotran_3","2.6.1.19_4-aminobutyrate transaminase","cellular organisms","Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization"]
["YGR035C","YGR035C",6321472,57,10,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YIL043C","CBR1",86558908,57,17,0,0,"FAD_binding_6~NAD_binding_1","NA","cellular organisms","Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia"]
["YIL116W","HIS5",6322075,57,13,0,0,"Aminotran_1_2","2.6.1.9_Histidinol-phosphate transaminase","cellular organisms","Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"]
["YLL060C","GTT2",6322968,57,11,0,0,"GST_N~GST_C","2.5.1.18_Glutathione transferase","cellular organisms","Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p"]
["YOR175C","ALE1",6324749,57,7,0,0,"MBOAT","2.3.1.23_1-acylglycerophosphocholine O-acyltransferase|2.3.1.51_1-acylglycerol-3-phosphate O-acyltransferase","Eukaryota","Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids"]
["YOR269W","PAC1",6324843,57,10,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1"]
["YPL031C","PHO85",6325226,57,19,0,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle"]
["YPR128C","ANT1",6325385,57,5,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation"]
["YAL056W","GPB2",41629666,57,20,0,1,"NA","NA","Saccharomycetaceae","Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p"]
["YDR296W","MHR1",6320502,57,10,0,1,"NA","NA","Saccharomycetales","Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning"]
["YER182W","FMP10",6321030,57,8,1,1,"NA","NA","Dikarya","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YGR215W","RSM27",6321654,57,9,0,1,"MRP-S33","NA","Eukaryota","Mitochondrial ribosomal protein of the small subunit"]
["YMR282C","AEP2",6323938,57,12,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader"]
["YNR040W","YNR040W",6324368,57,22,1,1,"NA","NA","Saccharomycetales","NA"]
["YGL089C","MF(ALPHA)2",6321349,56,7,0,0,"MF_alpha_N~MF_alpha~MF_alpha","NA","Saccharomycetaceae","Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2"]
["YGR256W","GND2",6321695,56,10,0,0,"NAD_binding_2~6PGD","NA","cellular organisms","6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone"]
["YHR061C","GIC1",6321852,56,6,0,0,"PBD","NA","Saccharomycetaceae","Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain"]
["YIR028W","DAL4",6322219,56,15,0,0,"Transp_cyt_pur","NA","cellular organisms","Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"]
["YIR032C","DAL3",6322223,56,7,0,0,"Ureidogly_hydro","3.5.3.19_Ureidoglycolate hydrolase","cellular organisms","Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression"]
["YJR134C","SGM1",6322594,56,8,0,0,"NA","NA","Fungi/Metazoa group","Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus"]
["YNL332W","THI12",6323997,56,16,0,0,"NMT1","NA","cellular organisms","Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"]
["YOR044W","IRC23",6324618,56,13,0,0,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci"]
["YPL033C","YPL033C",6325224,56,11,0,0,"NA","NA","cellular organisms","NA"]
["YCR071C","IMG2",10383803,56,10,0,1,"Img2","NA","Fungi/Metazoa group","Mitochondrial ribosomal protein of the small subunit"]
["YDR405W","MRP20",6320613,56,8,0,1,"Ribosomal_L23","NA","Fungi/Metazoa group","Mitochondrial ribosomal protein of the large subunit"]
["YJL133W","MRS3",6322328,56,20,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron"]
["YPL109C","YPL109C",50593504,56,14,1,1,"ABC1","NA","cellular organisms","NA"]
["YAR028W","YAR028W",6319332,55,4,1,0,"DUP","NA","Saccharomycetaceae","NA"]
["YBL001C","ECM15",6319472,55,7,0,0,"DUF77","NA","cellular organisms","Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis"]
["YCL004W","PGS1",10383778,55,5,0,0,"PLDc~PLDc","NA","cellular organisms","Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis"]
["YDL057W","YDL057W",6320146,55,6,1,0,"NA","NA","Eukaryota","NA"]
["YDR239C","YDR239C",6320445,55,7,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR346C","SVF1",6320553,55,13,0,0,"Svf1~SGT1","NA","Dikarya","Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis"]
["YDR423C","CAD1",6320631,55,16,0,0,"bZIP_2~bZIP_1~PAP1","NA","Saccharomycetaceae","AP-1-like bZIP transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; 5' UTR contains uORFs"]
["YHR157W","REC104",6321951,55,8,0,0,"NA","NA","Saccharomyces","Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination"]
["YKR010C","TOF2",6322862,55,10,0,0,"Cytokin_check_N","NA","Saccharomyces cerevisiae","Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1"]
["YMR031C","YMR031C",6323674,55,6,1,0,"NA","NA","Saccharomycetales","NA"]
["YNR059W","MNT4",6324387,55,14,0,0,"NA","NA","Dikarya","Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation"]
["YOR059C","YOR059C",6324633,55,6,1,0,"DUF676","NA","Eukaryota","NA"]
["YPL203W","TPK2",6325053,55,19,0,0,"Pkinase~Pkinase_Tyr~YrbL-PhoP_reg","2.7.11.11_cAMP-dependent protein kinase","cellular organisms","cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p"]
["YPR186C","PZF1",6325444,55,4,0,0,"zf-C2H2~zf-C2H2~zf-C2H2~zf-C2H2~zf-C2H2","NA","Eukaryota","Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNA"]
["YLR382C","NAM2",6323414,55,13,0,1,"tRNA-synt_1g~tRNA-synt_1~tRNA-synt_1d~tRNA-synt_1~tRNA-synt_1g~tRNA-synt_1","6.1.1.4_Leucine--tRNA ligase","cellular organisms","Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance"]
["YPL059W","GRX5",6325198,55,8,0,1,"Glutaredoxin","NA","cellular organisms","Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p"]
["YGL114W","YGL114W",6321324,54,7,1,0,"OPT","NA","cellular organisms","NA"]
["YKR075C","YKR075C",6322928,54,11,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLR044C","PDC1",6323073,54,14,0,0,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","4.1.1.1_Pyruvate decarboxylase","cellular organisms","Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism"]
["YLR385C","SWC7",6323417,54,7,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin"]
["YPL126W","NAN1",6325131,54,4,0,0,"WD40","NA","cellular organisms","U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA"]
["YPL248C","GAL4",6325008,54,4,0,0,"Zn_clus~Gal4_dimer~Fungal_trans","NA","Eukaryota","DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p"]
["YJL214W","HXT8",6322247,53,8,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose"]
["YDL125C","HNT1",6320078,53,6,0,0,"HIT","NA","cellular organisms","Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint"]
["YGL255W","ZRT1",6321182,53,5,0,0,"Zip","NA","Eukaryota","High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor"]
["YLR454W","FMP27",6323487,53,16,1,0,"DUF2405~Fmp27_SW~Fmp27_GFWDK~Fmp27_WPPW~Apt1","NA","Dikarya","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YNL242W","ATG2",6324087,53,6,0,0,"ATG_C","NA","Ascomycota","Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria"]
["YNR015W","SMM1",6324342,53,22,0,0,"Dus","NA","cellular organisms","Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs"]
["YOR012W","YOR012W",6324586,53,9,1,0,"NA","NA","Ascomycota","NA"]
["YOR242C","SSP2",6324816,53,10,0,0,"NA","NA","Saccharomycetales","Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis"]
["YPR093C","ASR1",37362706,53,5,0,0,"zf-C3HC4~C1_3~PHD","NA","Eukaryota","Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain"]
["YDL104C","QRI7",6320099,53,7,1,1,"Peptidase_M22","NA","cellular organisms","Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YPR047W","MSF1",37362703,53,9,0,1,"tRNA-synt_2d~tRNA-synt_2d~tRNA-synt_2d~FDX-ACB","6.1.1.20_Phenylalanine--tRNA ligase","cellular organisms","Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase"]
["YBL003C","HTA2",6319470,52,8,0,0,"Histone","NA","Eukaryota","One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p"]
["YBL058W","SHP1",6319413,52,19,0,0,"SEP~UBX","NA","Eukaryota","UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate"]
["YCR004C","YCP4",6319849,52,7,0,0,"Flavodoxin_1","NA","cellular organisms","Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YER033C","ZRG8",6320871,52,13,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency"]
["YER122C","GLO3",6320969,52,8,0,0,"ArfGap","NA","Eukaryota","ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p"]
["YGR248W","SOL4",6321687,52,3,0,0,"NA","3.1.1.31_6-phosphogluconolactonase","cellular organisms","6-phosphogluconolactonase with similarity to Sol3p"]
["YIL161W","YIL161W",6322030,52,18,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YJR061W","YJR061W",6322521,52,14,1,0,"LicD","NA","Saccharomycetales","NA"]
["YLR125W","YLR125W",6323154,52,8,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR144C","ACF2",6323173,52,8,0,0,"Glyco_hydro_81","3.2.1.6_Endo-1,3(4)-beta-glucanase","cellular organisms","Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly"]
["YLR312W-A","MRPL15",116006497,52,12,0,1,"Ribonuclease_3","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YBR043C","QDR3",6319517,51,13,0,0,"MFS_1","NA","cellular organisms","Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin"]
["YBR061C","TRM7",6319535,51,15,0,0,"FtsJ","NA","cellular organisms","2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop"]
["YBR062C","YBR062C",50593118,51,8,1,0,"NA","NA","Eukaryota","NA"]
["YCL005W","LDB16",10383777,51,30,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria"]
["YER152C","YER152C",6321000,51,5,1,0,"Aminotran_1_2","NA","cellular organisms","NA"]
["YER176W","ECM32",6321024,51,8,0,0,"NA","NA","cellular organisms","DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes"]
["YGR111W","YGR111W",6321549,51,7,1,0,"NA","NA","Ascomycota","NA"]
["YIL015W","BAR1",6322174,51,20,0,0,"Asp","3.4.23.35_Barrierpepsin","Eukaryota","Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest"]
["YIL030C","SSM4",6322159,51,12,0,0,"zf-C3HC4","NA","Fungi/Metazoa group","Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation"]
["YIR016W","YIR016W",6322206,51,12,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YJL134W","LCB3",6322327,51,21,0,0,"PAP2","NA","cellular organisms","Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids"]
["YJL213W","YJL213W",6322248,51,7,0,0,"Amidohydro_1~Amidohydro_3","NA","cellular organisms","NA"]
["YKR088C","TVP38",6322941,51,16,0,0,"SNARE_assoc~NfeD","NA","cellular organisms","Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YNL053W","MSG5",6324275,51,10,0,0,"DSPc","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; dephosphorylates Fus3p; required for adaptive response to pheromone"]
["YNL237W","YTP1",6324092,51,8,0,0,"Ytp1~TPT","NA","Dikarya","Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins"]
["YOR099W","KTR1",6324673,51,5,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family"]
["YPR156C","TPO3",6325414,51,9,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily"]
["YML009C","MRPL39",6323634,51,14,0,1,"NA","NA","Dikarya","Mitochondrial ribosomal protein of the large subunit"]
["YER187W","YER187W",6321035,50,4,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YHR009C","YHR009C",6321797,50,18,1,0,"Pyr_redox_2~DAO~DAO","NA","cellular organisms","NA"]
["YJL019W","MPS3",27808709,50,9,0,0,"NA","NA","Saccharomycetaceae","Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p"]
["YJR125C","ENT3",6322585,50,15,0,0,"ENTH","NA","Eukaryota","Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p"]
["YJR133W","XPT1",6322593,50,8,0,0,"Pribosyltran","NA","cellular organisms","Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine"]
["YJR154W","YJR154W",6322614,50,5,1,0,"PhyH","NA","cellular organisms","NA"]
["YKL130C","SHE2",6322719,50,9,0,0,"NA","NA","Saccharomycetaceae","RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud"]
["YLL010C","PSR1",6323019,50,16,0,0,"NIF","NA","cellular organisms","Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p"]
["YLR001C","YLR001C",6323029,50,5,1,0,"Fasciclin","NA","Ascomycota","NA"]
["YLR040C","YLR040C",6323070,50,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML027W","YOX1",6323614,50,13,0,0,"Homeobox","NA","Fungi/Metazoa group","Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate"]
["YML083C","YML083C",6323556,50,4,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR085W","YMR085W",6323731,50,8,1,0,"SIS~SIS","NA","cellular organisms","NA"]
["YMR140W","SIP5",6323789,50,7,0,0,"NA","NA","Dikarya","Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase"]
["YNL022C","YNL022C",6324306,50,11,1,0,"Nol1_Nop2_Fmu~Nol1_Nop2_Fmu","NA","cellular organisms","NA"]
["YNL146W","YNL146W",6324183,50,10,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YNL261W","ORC5",6324068,50,5,0,0,"NA","NA","Fungi/Metazoa group","Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"]
["YOR168W","GLN4",6324742,50,8,0,0,"tRNA_synt_1c_R1~tRNA_synt_1c_R2~tRNA-synt_1c~tRNA-synt_1c_C","6.1.1.18_Glutamine--tRNA ligase","cellular organisms","Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions"]
["YMR267W","PPA2",6323923,50,9,0,1,"Pyrophosphatase","NA","cellular organisms","Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate"]
["YNL306W","MRPS18",6324023,50,8,0,1,"NA","NA","Dikarya","Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins"]
["YEL071W","DLD3",6320764,49,9,0,0,"FAD_binding_4~FAD-oxidase_C","1.1.2.4_D-lactate dehydrogenase (cytochrome)","cellular organisms","D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm"]
["YER113C","TMN3",6320959,49,14,0,0,"EMP70","NA","Eukaryota","Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation"]
["YIL158W","AIM20",6322033,49,16,1,0,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YJR084W","CSN12",6322543,49,14,0,0,"PCI","NA","Eukaryota","Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"]
["YKR064W","OAF3",6322917,49,7,0,0,"Zn_clus","NA","Ascomycota","Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YLR247C","IRC20",6323276,49,11,0,0,"SNF2_N~zf-C3HC4~zf-P11~Helicase_C","NA","cellular organisms","Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci"]
["YLR300W","EXG1",6323331,49,12,0,0,"Cellulase","3.2.1.58_Glucan 1,3-beta-glucosidase","cellular organisms","Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes"]
["YMR210W","YMR210W",6323866,49,7,0,0,"Abhydrolase_1","NA","cellular organisms","NA"]
["YNL142W","MEP2",6324187,49,7,0,0,"Ammonium_transp","NA","cellular organisms","Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation"]
["YGL221C","NIF3",6321217,49,10,0,1,"NIF3","NA","cellular organisms","Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YIL087C","LRC2",6322104,49,17,1,1,"DUF2416","NA","Ascomycota","Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YMR145C","NDE1",6323794,49,20,0,1,"Pyr_redox_2~Pyr_redox","1.6.5.3_NADH dehydrogenase (ubiquinone)","cellular organisms","Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain"]
["YOR150W","MRPL23",6324724,49,7,0,1,"Ribosomal_L13","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YBL021C","HAP3",6319450,48,8,0,0,"CBFD_NFYB_HMF~Histone","NA","Eukaryota","Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding"]
["YDR111C","ALT2",6320317,48,6,1,0,"Aminotran_1_2~Aminotran_1_2","2.6.1.2_Alanine transaminase","cellular organisms","Putative alanine transaminase (glutamic pyruvic transaminase)"]
["YGL262W","YGL262W",6321175,48,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGR129W","SYF2",6321568,48,5,0,0,"SYF2","NA","Ascomycota","Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression"]
["YHL016C","DUR3",6321771,48,9,0,0,"NA","NA","cellular organisms","Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway"]
["YIL108W","YIL108W",6322083,48,9,1,0,"Jacalin","NA","cellular organisms","NA"]
["YIL156W","UBP7",6322035,48,14,0,0,"Rhodanese~UCH","3.1.2.15_Ubiquitin thiolesterase","Eukaryota","Ubiquitin-specific protease that cleaves ubiquitin-protein fusions"]
["YJL144W","YJL144W",6322317,48,23,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YML004C","GLO1",6323639,48,4,0,0,"Glyoxalase~Glyoxalase","4.4.1.5_Lactoylglutathione lyase","cellular organisms","Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress"]
["YOR180C","DCI1",6324754,48,7,0,0,"NA","NA","cellular organisms","Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini"]
["YPR145W","ASN1",6325403,48,4,0,0,"Asn_synthase~Evr1_Alr","NA","cellular organisms","Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway"]
["YFL046W","FMP32",14318473,48,6,1,1,"DUF1640","NA","Eukaryota","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YGL107C","RMD9",6321331,48,7,0,1,"NA","NA","Saccharomycetales","Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes"]
["YDR210W","YDR210W",6320415,47,6,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDR307W","YDR307W",6320513,47,13,1,0,"MIR","2.4.1.109_Dolichyl-phosphate-mannose-protein mannosyltransferase","Fungi/Metazoa group","NA"]
["YER118C","SHO1",6320964,47,7,0,0,"SH3_1~SH3_2","NA","Eukaryota","Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway"]
["YGR189C","CRH1",6321628,47,8,0,0,"Glyco_hydro_16","NA","cellular organisms","Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions"]
["YHR115C","DMA1",6321907,47,17,0,0,"FHA","NA","Eukaryota","Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr."]
["YHR193C","EGD2",6321987,47,12,0,0,"NAC~UBA","NA","Eukaryota","Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes"]
["YMR192W","GYL1",6323846,47,14,0,0,"TBC","NA","Eukaryota","Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p"]
["YOR174W","MED4",6324748,47,7,0,0,"NA","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YOR348C","PUT4",6324924,47,8,0,0,"AA_permease","NA","cellular organisms","Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells"]
["YPL032C","SVL3",6325225,47,16,0,0,"NA","NA","Ascomycota","Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck"]
["YBR282W","MRPL27",6319759,47,13,0,1,"MRP-L27","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit"]
["YDR298C","ATP5",6320504,47,12,0,1,"OSCP","NA","cellular organisms","Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated"]
["YJL063C","MRPL8",6322398,47,8,0,1,"Ribosomal_L17","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YBR071W","YBR071W",6319545,46,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBR301W","DAN3",6319777,46,6,0,0,"SRP1_TIP1","NA","Saccharomycetaceae","Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"]
["YCR100C","YCR100C",6319943,46,4,1,0,"NA","NA","Eukaryota","NA"]
["YDR099W","BMH2",6320304,46,15,0,0,"14-3-3","NA","Eukaryota","14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling"]
["YFL012W","YFL012W",14318509,46,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YFR015C","GSY1",14318537,46,3,0,0,"Glycogen_syn~Glycos_transf_1","2.4.1.11_Glycogen(starch) synthase","cellular organisms","Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase"]
["YGL033W","HOP2",9755333,46,13,0,0,"TBPIP","NA","Eukaryota","Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair"]
["YGR099W","TEL2",6321536,46,6,0,0,"Telomere_reg-2","NA","Ascomycota","Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect"]
["YGR161C","RTS3",6321600,46,4,1,0,"NA","NA","Saccharomyces cerevisiae","Putative component of the protein phosphatase type 2A complex"]
["YHR152W","SPO12",6321946,46,9,0,0,"Spo12","NA","Saccharomycetaceae","Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis"]
["YIL005W","EPS1",6322186,46,21,0,0,"Thioredoxin","5.3.4.1_Protein disulfide-isomerase","Eukaryota","ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family"]
["YIL020C","HIS6",6322169,46,13,0,0,"His_biosynth","5.3.1.16_isomerase","cellular organisms","Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"]
["YJL151C","SNA3",6322310,46,8,0,0,"UPF0057","NA","cellular organisms","Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting"]
["YJR124C","YJR124C",6322584,46,6,1,0,"MFS_1~Sugar_tr~MFS_1","NA","cellular organisms","NA"]
["YKL034W","TUL1",6322817,46,13,0,0,"zf-C3HC4","NA","Eukaryota","Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes"]
["YKL046C","DCW1",6322805,46,13,0,0,"Glyco_hydro_76","3.2.1.101_Mannan endo-1,6-alpha-mannosidase","cellular organisms","Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p"]
["YKR095W","MLP1",6322948,46,17,0,0,"Ax_dynein_light~TPR_MLP1_2","NA","Eukaryota","Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs"]
["YLR250W","SSP120",6323279,46,10,0,0,"NA","NA","Dikarya","Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YMR110C","HFD1",6323757,46,9,0,0,"Aldedh~Aldedh~Aldedh","NA","cellular organisms","Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome"]
["YMR169C","ALD3",6323821,46,6,0,0,"Aldedh","NA","cellular organisms","Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose"]
["YNL093W","YPT53",6324236,46,7,0,0,"Miro~Ras","NA","cellular organisms","GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"]
["YKR070W","YKR070W",6322923,46,6,1,1,"Hydrolase~THF_DHG_CYH","NA","cellular organisms","NA"]
["YJR152W","DAL5",6322612,45,17,0,0,"MFS_1","NA","cellular organisms","Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression"]
["YER169W","RPH1",6321017,45,7,0,0,"JmjN~JmjC~zf-C2H2~zf-C2H2","NA","Eukaryota","JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway"]
["YGL002W","ERP6",6321436,45,2,0,0,"EMP24_GP25L","NA","Eukaryota","Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YGR106C","YGR106C",6321543,45,29,0,0,"BIG1","NA","Saccharomycetaceae","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane"]
["YHR126C","YHR126C",6321918,45,10,1,0,"PIR","NA","Saccharomyces cerevisiae","NA"]
["YIL023C","YKE4",6322166,45,16,0,0,"Zip","NA","cellular organisms","Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family"]
["YIL066C","RNR3",6322123,45,15,0,0,"ATP-cone~Ribonuc_red_lgN~Ribonuc_red_lgC","1.17.4.1_Ribonucleoside-diphosphate reductase","cellular organisms","One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits"]
["YLL026W","HSP104",6323002,45,18,0,0,"Clp_N~Clp_N~AAA~AAA_2~AAA_5~ClpB_D2-small","NA","cellular organisms","Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation"]
["YLL058W","YLL058W",6322970,45,5,1,0,"Cys_Met_Meta_PP","2.5.1.48_Cystathionine gamma-synthase","cellular organisms","NA"]
["YMR008C","PLB1",6323650,45,4,0,0,"PLA2_B","3.1.1.5_Lysophospholipase","Fungi/Metazoa group","Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol"]
["YMR124W","YMR124W",6323772,45,27,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR303C","ADH2",6323961,45,7,0,0,"ADH_N~ADH_zinc_N","1.1.1.1_Alcohol dehydrogenase","cellular organisms","Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1"]
["YOR166C","SWT1",6324740,45,6,0,0,"NA","NA","cellular organisms","Protein of unknown function; involved in transcription associated process; interacts genetically and physically with the TREX complex and RNA polymerase II; contains a PINc domain (PilT N terminus); localizes in the nucleus"]
["YPL129W","TAF14",6325128,45,24,0,0,"YEATS","NA","Eukaryota","Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain"]
["YDL066W","IDP1",6320137,45,29,0,1,"Iso_dh","1.1.1.42_Isocitrate dehydrogenase (NADP(+))","cellular organisms","Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes"]
["YDR316W","OMS1",6320522,45,6,0,1,"Methyltransf_11~Methyltransf_12","NA","cellular organisms","Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations"]
["YCL069W","VBA3",6319783,44,3,0,0,"MFS_1~TRI12~MFS_1~Sugar_tr","NA","cellular organisms","Permease of basic amino acids in the vacuolar membrane"]
["YHR142W","CHS7",6321935,44,18,0,0,"NA","NA","Dikarya","Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER"]
["YIL123W","SIM1",6322068,44,16,0,0,"SUN","NA","Eukaryota","Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated"]
["YJL162C","JJJ2",85666118,44,19,0,0,"DnaJ","NA","cellular organisms","Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein"]
["YKL091C","YKL091C",6322759,44,6,0,0,"CRAL_TRIO_N~CRAL_TRIO","NA","Eukaryota","NA"]
["YLR405W","DUS4",6323437,44,6,0,0,"Dus","NA","cellular organisms","Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p"]
["YML024W","RPS17A",6323617,44,8,0,0,"Ribosomal_S17e","NA","cellular organisms","Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein"]
["YNL163C","RIA1",6324166,44,5,0,0,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~EFG_IV~EFG_C","NA","cellular organisms","Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)"]
["YNL336W","COS1",6323993,44,8,0,0,"DUP~DUP","NA","Saccharomycetaceae","Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"]
["YOR272W","YTM1",6324846,44,4,0,0,"NLE~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit"]
["YPR184W","GDB1",6325442,44,8,0,0,"GDE_C","2.4.1.25_4-alpha-glucanotransferase|3.2.1.33_Amylo-alpha-1,6-glucosidase","cellular organisms","Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria"]
["YHR037W","PUT2",6321826,44,4,0,1,"Aldedh~Aldedh","1.5.1.12_1-pyrroline-5-carboxylate dehydrogenase","cellular organisms","Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism"]
["YKL003C","MRP17",6322850,44,4,0,1,"NA","NA","Eukaryota","Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator"]
["YDL169C","UGX2",6320032,43,8,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, transcript accumulates in response to any combination of stress conditions"]
["YDR201W","SPC19",6320407,43,7,0,0,"DASH_Spc19","NA","Saccharomycetaceae","Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body"]
["YGR001C","AML1",9755334,43,10,1,0,"DPPF","NA","Eukaryota","Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae"]
["YHR023W","MYO1",6321812,43,6,0,0,"Myosin_N~Myosin_head","NA","Eukaryota","Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively"]
["YJR141W","YJR141W",6322601,43,9,1,0,"DUF2351","NA","Fungi/Metazoa group","NA"]
["YJR148W","BAT2",6322608,43,6,0,0,"Aminotran_4","2.6.1.42_Branched-chain-amino-acid transaminase","cellular organisms","Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase"]
["YLL003W","SFI1",6323026,43,4,0,0,"Sfi1~Sfi1_C","NA","Dikarya","Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C"]
["YLR241W","YLR241W",6323270,43,7,1,0,"DUF221","NA","Eukaryota","NA"]
["YMR102C","YMR102C",6323749,43,19,1,0,"WD40~WD40~WD40","NA","cellular organisms","NA"]
["YMR184W","ADD37",6323838,43,6,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene"]
["YOR255W","OSW1",6324829,43,7,0,0,"NA","NA","Saccharomycetaceae","Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p"]
["YPL220W","RPL1A",6325036,43,6,0,0,"Ribosomal_L1","NA","cellular organisms","N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal"]
["YPR083W","MDM36",6325340,43,12,0,0,"NA","NA","Saccharomycetales","Protein required for normal mitochondrial morphology and inheritance"]
["YER061C","CEM1",6320904,43,15,0,1,"ketoacyl-synt~Ketoacyl-synt_C","2.3.1.41_Beta-ketoacyl-acyl-carrier-protein synthase I","cellular organisms","Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration"]
["YJR003C","YJR003C",99030925,43,13,1,1,"NA","NA","Saccharomycetales","NA"]
["YOL158C","ENB1",6324415,42,5,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment"]
["YMR011W","HXT2",6323653,42,4,0,0,"MFS_1~Sugar_tr~MFS_1","NA","cellular organisms","High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose"]
["YBR110W","ALG1",6319586,42,8,0,0,"Glycos_transf_1","2.4.1.142_Chitobiosyldiphosphodolichol beta-mannosyltransferase","cellular organisms","Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog"]
["YDL092W","SRP14",6320111,42,7,0,0,"SRP14","NA","Dikarya","Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14"]
["YDL131W","LYS21",6320071,42,3,0,0,"HMGL-like","2.3.3.14_Homocitrate synthase","cellular organisms","Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p"]
["YDR006C","SOK1",6320209,42,14,0,0,"Tcp11","NA","Fungi/Metazoa group","Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13"]
["YDR195W","REF2",6320401,42,22,0,0,"NA","NA","Saccharomycetaceae","RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes"]
["YHR185C","PFS1",6321979,42,8,0,0,"NA","NA","Saccharomycetaceae","Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation"]
["YIL053W","RHR2",86558907,42,32,0,0,"Hydrolase","NA","cellular organisms","Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress"]
["YIL057C","YIL057C",6322132,42,25,1,0,"NA","NA","Saccharomycetales","NA"]
["YJL026W","RNR2",6322434,42,7,0,0,"Ribonuc_red_sm","1.17.4.1_Ribonucleoside-diphosphate reductase","cellular organisms","Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"]
["YJL057C","IKS1",6322404,42,8,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p"]
["YJL132W","YJL132W",6322329,42,6,1,0,"NA","NA","Fungi/Metazoa group","NA"]
["YJL206C","YJL206C",6322255,42,8,1,0,"Zn_clus~Fungal_trans","NA","Dikarya","NA"]
["YJR144W","MGM101",6322604,42,14,0,0,"Mgm101p","NA","cellular organisms","Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage"]
["YKR043C","YKR043C",6322896,42,7,1,0,"PGAM","NA","cellular organisms","NA"]
["YML074C","FPR3",6323566,42,11,0,0,"FKBP_C","NA","cellular organisms","Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p"]
["YMR144W","YMR144W",6323793,42,12,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YNL249C","MPA43",6324080,42,8,0,0,"NA","NA","cellular organisms","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YOR384W","FRE5",6324960,42,9,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","cellular organisms","Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YCR028C-A","RIM1",10383791,42,5,0,1,"SSB","NA","cellular organisms","Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication"]
["YJL060W","BNA3",6322401,42,13,0,1,"Aminotran_1_2","NA","cellular organisms","Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate"]
["YER137C","YER137C",6320984,41,4,1,0,"NA","NA","Saccharomycetales","NA"]
["YGR136W","LSB1",6321575,41,7,0,0,"SH3_1~SH3_2","NA","Fungi/Metazoa group","Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"]
["YGR167W","CLC1",6321606,41,20,0,0,"Clathrin_lg_ch","NA","Fungi/Metazoa group","Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component"]
["YHR076W","PTC7",154199605,41,3,0,0,"PP2C~SpoIIE","NA","cellular organisms","Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments"]
["YIL166C","YIL166C",6322025,41,8,1,0,"MFS_1","NA","cellular organisms","NA"]
["YKL179C","COY1",6322669,41,13,0,0,"CASP_C","NA","Eukaryota","Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function"]
["YML051W","GAL80",6323590,41,4,0,0,"GFO_IDH_MocA","NA","cellular organisms","Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding"]
["YMR019W","STB4",6323661,41,4,0,0,"Zn_clus~Fungal_trans","NA","Saccharomycetales","Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins"]
["YMR055C","BUB2",6323700,41,13,0,0,"TBC","NA","Eukaryota","Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage"]
["YMR215W","GAS3",6323871,41,7,0,0,"Glyco_hydro_72","NA","Eukaryota","Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall"]
["YMR271C","URA10",6323927,41,10,0,0,"Pribosyltran","2.4.2.10_Orotate phosphoribosyltransferase","cellular organisms","Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5"]
["YNR002C","ATO2",6324329,41,5,0,0,"Grp1_Fun34_YaaH","NA","cellular organisms","Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p"]
["YBR179C","FZO1",6319656,41,18,0,1,"Dynamin_N~MMR_HSR1","NA","cellular organisms","Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain"]
["YBR251W","MRPS5",6319728,41,12,0,1,"Ribosomal_S5~Ribosomal_S5_C","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YIL111W","COX5B",6322080,41,16,0,1,"COX4","NA","Fungi/Metazoa group","Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth"]
["YNL213C","YNL213C",6324116,41,10,0,1,"Neugrin~Sigma70_r4","NA","Dikarya","NA"]
["YDL079C","MRK1",6320124,40,8,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation"]
["YDL227C","HO",6319974,40,16,0,0,"Hom_end_hint~Hom_end","NA","Ascomycota","Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p"]
["YDR364C","CDC40",6320572,40,10,0,0,"WD40~WD40~WD40","NA","cellular organisms","Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats"]
["YDR490C","PKH1",6320698,40,14,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p"]
["YER114C","BOI2",6320960,40,11,0,0,"SH3_1~SH3_2~SAM_2~PH","NA","Ascomycota","Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"]
["YGR241C","YAP1802",6321681,40,14,0,0,"ANTH~ENTH","NA","Eukaryota","Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family"]
["YHR086W","NAM8",6321878,40,12,0,0,"RRM_1~RRM_1~RRM_1","NA","Eukaryota","RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA"]
["YHR134W","WSS1",6321926,40,16,0,0,"WLM","NA","Eukaryota","Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks"]
["YJL176C","SWI3",6322286,40,23,0,0,"SWIRM~Myb_DNA-binding","NA","Eukaryota","Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2"]
["YJR035W","RAD26",6322495,40,7,0,0,"SNF2_N~Helicase_C","NA","cellular organisms","Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein"]
["YJR096W","YJR096W",6322556,40,5,0,0,"Aldo_ket_red","NA","cellular organisms","NA"]
["YKL103C","LAP4",6322746,40,9,0,0,"Peptidase_M18","3.4.11.22_Aminopeptidase I","cellular organisms","Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway"]
["YKL119C","VPH2",6322731,40,28,0,0,"NA","NA","Ascomycota","Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)"]
["YKR050W","TRK2",6322903,40,3,0,0,"TrkH","NA","cellular organisms","Component of the Trk1p-Trk2p potassium transport system"]
["YLL049W","LDB18",6322979,40,13,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface"]
["YML005W","TRM12",6323638,40,6,0,0,"Met_10","NA","cellular organisms","S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA"]
["YML109W","ZDS2",6323527,40,7,0,0,"Zds1_C","NA","Saccharomycetales","Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p"]
["YMR147W","YMR147W",6323796,40,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR226C","TMA29",6323882,40,6,0,0,"adh_short","NA","cellular organisms","NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments"]
["YNL068C","FKH2",6324261,40,21,0,0,"FHA~Fork_head","NA","Ascomycota","Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase"]
["YNL290W","RFC3",6324039,40,8,0,0,"AAA~Mg_chelatase~Rep_fac_C","NA","cellular organisms","Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"]
["YOL162W","YOL162W",6324411,40,9,1,0,"NA","NA","Dikarya","NA"]
["YPL130W","SPO19",6325127,40,8,0,0,"NA","NA","Saccharomycetaceae","Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein"]
["YDL164C","CDC9",6320038,40,7,0,1,"DNA_ligase_A_N~DNA_ligase_A_M~DNA_ligase_A_C","NA","cellular organisms","DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination"]
["YPL168W","YPL168W",6325089,40,9,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YEL065W","SIT1",6320770,39,9,0,0,"MFS_1","NA","cellular organisms","Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p"]
["YAL027W","SAW1",6319292,39,7,0,0,"NA","NA","Saccharomycetaceae","Catalyzes 3'-nonhomologous tail removal of Rad1p/Rad10p-dependent single-strand annealing recombination intermediates; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene"]
["YBL075C","SSA3",6319396,39,5,0,0,"HSP70","NA","cellular organisms","ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm"]
["YDR058C","TGL2",6320263,39,10,0,0,"Fiji_64_capsid~DUF676","3.1.1.3_Triacylglycerol lipase","cellular organisms","Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear"]
["YDR174W","HMO1",6320379,39,13,0,0,"HMG_box","NA","Eukaryota","Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase"]
["YDR321W","ASP1",6320527,39,5,0,0,"Asparaginase","NA","cellular organisms","Cytosolic L-asparaginase, involved in asparagine catabolism"]
["YGL081W","YGL081W",6321357,39,4,1,0,"FHA","NA","Saccharomycetaceae","NA"]
["YGR249W","MGA1",6321688,39,3,0,0,"HSF_DNA-bind","NA","Eukaryota","Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants"]
["YHL028W","WSC4",6321759,39,8,0,0,"WSC","NA","Fungi/Metazoa group","ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3"]
["YHL044W","YHL044W",6321743,39,24,1,0,"DUP","NA","Saccharomycetaceae","NA"]
["YHR138C","YHR138C",6321930,39,9,1,0,"NA","NA","Ascomycota","NA"]
["YHR184W","SSP1",6321978,39,5,0,0,"NA","NA","Saccharomycetaceae","Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis"]
["YJR048W","CYC1",6322508,39,10,0,0,"Cytochrom_C","NA","cellular organisms","Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"]
["YLL054C","YLL054C",6322974,39,6,1,0,"Zn_clus","NA","Saccharomycetales","NA"]
["YLR080W","EMP46",6323109,39,13,0,0,"Lectin_leg-like","NA","Fungi/Metazoa group","Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"]
["YLR353W","BUD8",6323385,39,10,0,0,"NA","NA","Saccharomycetaceae","Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole"]
["YML111W","BUL2",6323525,39,10,0,0,"Bul1_N~Bul1_C","NA","Saccharomycetales","Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1"]
["YMR206W","YMR206W",6323862,39,9,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YNL165W","YNL165W",6324164,39,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOL152W","FRE7",84626311,39,8,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","cellular organisms","Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels"]
["YOR092W","ECM3",6324666,39,3,0,0,"Mem_trans","NA","Dikarya","Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation"]
["YPL234C","TFP3",6325022,39,26,0,0,"ATP-synt_C~ATP-synt_C","NA","cellular organisms","Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen"]
["YPR063C","YPR063C",6325320,39,6,1,0,"NA","NA","Ascomycota","NA"]
["YER170W","ADK2",6321018,39,6,0,1,"ADK~ADK_lid","2.7.4.3_Adenylate kinase","cellular organisms","Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background"]
["YER178W","PDA1",37362644,39,11,0,1,"E1_dh","1.2.4.1_Pyruvate dehydrogenase (acetyl-transferring)","cellular organisms","E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose"]
["YJR080C","AIM24",6322540,39,3,1,1,"NA","NA","Ascomycota","Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media"]
["YOL023W","IFM1",6324550,39,7,0,1,"IF2_N~GTP_EFTU~MMR_HSR1~GTP_EFTU_D2","NA","cellular organisms","Mitochondrial translation initiation factor 2"]
["YAL028W","FRT2",6319291,38,5,0,0,"NA","NA","Saccharomycetaceae","Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate"]
["YBR057C","MUM2",6319531,38,6,0,0,"NA","NA","Saccharomycetales","Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex"]
["YBR090C","YBR090C",6319566,38,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YCL028W","RNQ1",10383762,38,7,0,0,"NA","NA","Saccharomycetaceae","[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate"]
["YCR032W","BPH1",10383794,38,10,0,0,"Beach","NA","Fungi/Metazoa group","PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting"]
["YCR090C","YCR090C",6319933,38,7,1,0,"DUF866","NA","Eukaryota","NA"]
["YDL084W","SUB2",6320119,38,16,0,0,"DEAD~Helicase_C","NA","cellular organisms","Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56"]
["YDL185W","TFP1",6320016,38,24,0,0,"ATP-synt_ab_N~ATP-synt_ab~Hom_end_hint~Hom_end~Hom_end~ATP-synt_ab~ATP-synt_ab_C","3.6.3.14_H(+)-transporting two-sector ATPase","cellular organisms","Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease"]
["YDR034C","LYS14",6320237,38,6,0,0,"Zn_clus","NA","Ascomycota","Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer"]
["YER185W","PUG1",6321033,38,5,0,0,"RTA1","NA","Eukaryota","Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions"]
["YGR085C","RPL11B",6321522,38,6,0,0,"Ribosomal_L5~Ribosomal_L5_C","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11"]
["YHL043W","ECM34",6321744,38,12,0,0,"DUP","NA","Saccharomycetaceae","Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"]
["YHR049W","FSH1",6321839,38,4,0,0,"FSH1","NA","Eukaryota","Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p"]
["YJL178C","ATG27",42742253,38,20,0,0,"ATG27","NA","Saccharomycetales","Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the pre-autophagosomal structure; binds phosphatidylinositol 3-phosphate"]
["YKL096W","CWP1",6322754,38,6,0,0,"PIR","NA","Saccharomycetales","Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization"]
["YLL063C","AYT1",6322965,38,9,0,0,"Transferase","NA","Eukaryota","Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis"]
["YML003W","YML003W",6323640,38,10,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YMR280C","CAT8",6323936,38,8,0,0,"Zn_clus~Fungal_trans","NA","Ascomycota","Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements"]
["YNL054W","VAC7",6324274,38,5,0,0,"NA","NA","Saccharomycetaceae","Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock"]
["YNL335W","DDI3",6323994,38,13,1,0,"HD","NA","cellular organisms","Hypothetical protein"]
["YNR057C","BIO4",6324385,38,13,0,0,"NA","6.3.3.3_Dethiobiotin synthase","cellular organisms","Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels"]
["YNR060W","FRE4",6324388,38,12,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","cellular organisms","Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels"]
["YOR052C","YOR052C",6324626,38,15,0,0,"zf-AN1","NA","Dikarya","NA"]
["YOR342C","YOR342C",6324918,38,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL036W","PMA2",6325221,38,11,0,0,"Cation_ATPase_N~E1-E2_ATPase~Hydrolase","3.6.3.6_Proton-exporting ATPase","cellular organisms","Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential"]
["YLR139C","SLS1",6323168,38,11,0,1,"NA","NA","Saccharomycetales","Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery"]
["YLR239C","LIP2",6323268,38,8,0,1,"BPL_LipA_LipB","2.3.1.181_Lipoyl(octanoyl) transferase","cellular organisms","Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups"]
["YHR092C","HXT4",6321884,37,8,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose"]
["YBR092C","PHO3",6319568,37,7,0,0,"Acid_phosphat_A","3.1.3.2_Acid phosphatase","Fungi/Metazoa group","Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin"]
["YBR242W","YBR242W",6319719,37,6,1,0,"HD","NA","cellular organisms","NA"]
["YBR273C","UBX7",6319750,37,4,0,0,"UBX","NA","Fungi/Metazoa group","UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p"]
["YBR287W","YBR287W",6319764,37,14,1,0,"Mem_trans","NA","Eukaryota","NA"]
["YER008C","SEC3",6320845,37,9,0,0,"Sec3","NA","Dikarya","Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion"]
["YER085C","YER085C",6320929,37,8,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGR144W","THI4",6321583,37,13,0,0,"Thi4~HI0933_like~DAO~FAD_binding_2~Lycopene_cycl~Pyr_redox_2","NA","cellular organisms","Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability"]
["YGR197C","SNG1",6321636,37,17,0,0,"Carla_C4","NA","Dikarya","Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance"]
["YIL085C","KTR7",6322106,37,7,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Fungi","Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"]
["YIL135C","VHS2",6322056,37,18,0,0,"NA","NA","Saccharomycetaceae","Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p"]
["YJL153C","INO1",37362665,37,19,0,0,"NAD_binding_5~Inos-1-P_synth","5.5.1.4_Inositol-3-phosphate synthase","cellular organisms","Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element"]
["YKL033W-A","YKL033W-A",42759861,37,21,1,0,"Hydrolase","NA","cellular organisms","NA"]
["YKR017C","YKR017C",6322869,37,8,1,0,"zf-C3HC4~IBR","NA","Eukaryota","NA"]
["YKR059W","TIF1",6322912,37,13,0,0,"DEAD~Helicase_C","NA","cellular organisms","Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G"]
["YKR060W","UTP30",6322913,37,5,0,0,"NA","NA","Eukaryota","Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"]
["YLL034C","RIX7",6322994,37,9,0,0,"AAA~AAA_3~AAA_5~ABC_tran~Mg_chelatase~NifW~Zeta_toxin~AAA_2~AAA~AAA_3~AAA_5~Mg_chelatase~Vps4_C","NA","cellular organisms","Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions"]
["YLR005W","SSL1",6323033,37,5,0,0,"Ssl1~C1_4","NA","Eukaryota","Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p"]
["YLR030W","YLR030W",6323058,37,3,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR284C","ECI1",6323314,37,14,0,0,"ECH","5.3.3.8_Dodecenoyl-CoA isomerase","cellular organisms","Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced"]
["YLR325C","RPL38",6323357,37,8,0,0,"Ribosomal_L38e","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein"]
["YLR455W","YLR455W",6323488,37,8,1,0,"PWWP","NA","Ascomycota","NA"]
["YMR234W","RNH1",6323890,37,4,0,0,"RnaseH","3.1.26.4_Ribonuclease H","cellular organisms","Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)"]
["YNL166C","BNI5",6324163,37,18,0,0,"NA","NA","Saccharomycetales","Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner"]
["YNL272C","SEC2",6324057,37,6,0,0,"Sec2p","NA","Fungi/Metazoa group","Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport"]
["YOR007C","SGT2",6324580,37,21,0,0,"TPR_2~TPR_1~TPR_2~TPR_1~TPR_2","NA","cellular organisms","Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70"]
["YOR264W","DSE3",6324837,37,10,0,0,"NA","NA","Saccharomycetaceae","Daughter cell-specific protein, may help establish daughter fate"]
["YOR317W","FAA1",6324893,37,10,0,0,"AMP-binding~AMP-binding","6.2.1.3_Long-chain-fatty-acid--CoA ligase","cellular organisms","Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase"]
["YPL052W","OAZ1",83722566,37,11,0,0,"NA","NA","Saccharomycetaceae","Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated"]
["YPL115C","BEM3",6325142,37,25,0,0,"PX~PH~RhoGAP","NA","Dikarya","Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly"]
["YCR079W","PTC6",10383808,37,25,0,1,"PP2C","NA","Eukaryota","Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc5p"]
["YDL130W-A","STF1",6320072,37,6,0,1,"IATP","NA","Dikarya","Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein"]
["YJL208C","NUC1",6322253,37,12,0,1,"Endonuclease_NS","NA","cellular organisms","Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy"]
["YOR334W","MRS2",6324909,37,9,0,1,"CorA~Leptin","NA","Eukaryota","Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns"]
["YAR035W","YAT1",6319337,36,7,0,0,"Carn_acyltransf","2.3.1.7_Carnitine O-acetyltransferase","cellular organisms","Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated"]
["YBR010W","HHT1",6319482,36,8,0,0,"Histone","NA","Eukaryota","One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation"]
["YCL035C","GRX1",6319814,36,9,0,0,"Glutaredoxin","NA","cellular organisms","Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage"]
["YDR237W","MRPL7",6320443,36,6,0,0,"Ribosomal_L5~Ribosomal_L5_C","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YDR480W","DIG2",6320688,36,14,0,0,"NA","NA","Saccharomycetaceae","Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription"]
["YER064C","YER064C",6320907,36,10,1,0,"Vhr1","NA","Saccharomycetales","NA"]
["YER179W","DMC1",6321027,36,6,0,0,"Rad51","NA","cellular organisms","Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein"]
["YGR123C","PPT1",6321562,36,8,0,0,"TPR_1~TPR_2~PPP5~Metallophos","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing"]
["YHL039W","YHL039W",6321748,36,4,1,0,"SET","NA","Eukaryota","NA"]
["YHR039C-A","VMA10",6321829,36,13,0,0,"V-ATPase_G","NA","Eukaryota","Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification"]
["YHR043C","DOG2",6321833,36,3,0,0,"Hydrolase","3.1.3.68_2-deoxyglucose-6-phosphatase","cellular organisms","2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed"]
["YHR121W","LSM12",6321913,36,25,0,0,"AD","NA","Eukaryota","Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS"]
["YIR029W","DAL2",6322220,36,4,0,0,"Allantoicase~Allantoicase","3.5.3.4_Allantoicase","cellular organisms","Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"]
["YJL055W","YJL055W",6322406,36,6,1,0,"Lysine_decarbox","NA","cellular organisms","NA"]
["YKL221W","MCH2",6322628,36,4,0,0,"MFS_1","NA","cellular organisms","Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"]
["YKR058W","GLG1",83578103,36,5,0,0,"Glyco_transf_8","2.4.1.186_Glycogenin glucosyltransferase","cellular organisms","Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin"]
["YKR063C","LAS1",6322916,36,2,0,0,"Las1","NA","Eukaryota","Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability"]
["YLR003C","YLR003C",6323031,36,16,1,0,"NA","NA","Dikarya","NA"]
["YLR036C","YLR036C",6323065,36,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR327C","TMA10",6323359,36,8,0,0,"HABP4_PAI-RBP1","NA","Saccharomycetales","Protein of unknown function that associates with ribosomes"]
["YNL085W","MKT1",6324244,36,6,0,0,"XPG_N","NA","Eukaryota","Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus; contains a DTG signature typical of retroviral proteases"]
["YNL278W","CAF120",6324051,36,16,0,0,"PH","NA","Ascomycota","Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation"]
["YNR058W","BIO3",6324386,36,6,0,0,"Aminotran_3","2.6.1.62_Adenosylmethionine--8-amino-7-oxononanoate transaminase","cellular organisms","7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis"]
["YOR371C","GPB1",6324947,36,23,0,0,"NA","NA","Saccharomycetaceae","Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p"]
["YPL112C","PEX25",6325145,36,9,0,0,"NA","NA","Saccharomycetales","Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p"]
["YHR120W","MSH1",6321912,36,16,0,1,"MutS_I~MutS_II~MutS_III~MutS_V","NA","cellular organisms","DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis"]
["YOR305W","YOR305W",6324881,36,7,1,1,"DUF2034","NA","Dikarya","NA"]
["YPL118W","MRP51",6325139,36,10,0,1,"NA","NA","Ascomycota","Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences"]
["YPR098C","YPR098C",37362707,36,5,0,1,"NA","NA","cellular organisms","NA"]
["YPR116W","YPR116W",6325373,36,6,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YHL040C","ARN1",6321747,35,14,0,0,"MFS_1~MFS_1","NA","cellular organisms","Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores"]
["YHR096C","HXT5",6321888,35,4,0,0,"Sugar_tr~MFS_1~MFS_1","NA","cellular organisms","Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs"]
["YBL086C","YBL086C",6319385,35,19,1,0,"Eeig1","NA","Ascomycota","NA"]
["YBR180W","DTR1",6319657,35,8,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters"]
["YBR223C","TDP1",6319701,35,9,0,0,"Tyr-DNA_phospho","NA","Eukaryota","Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I"]
["YCR076C","YCR076C",6319920,35,13,1,0,"PI31_Prot_Reg","NA","Saccharomycetaceae","NA"]
["YCR098C","GIT1",6319941,35,15,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability"]
["YER023W","PRO3",6320861,35,2,0,0,"F420_oxidored","1.5.1.2_Pyrroline-5-carboxylate reductase","cellular organisms","Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis"]
["YFL004W","VTC2",14318518,35,5,0,0,"SPX~VTC~MBOAT","NA","Eukaryota","Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion"]
["YFR016C","YFR016C",14318538,35,12,0,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YKR106W","YKR106W",6322959,35,11,1,0,"NA","NA","cellular organisms","NA"]
["YLR207W","HRD3",6323236,35,12,0,0,"Sel1","NA","cellular organisms","Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events"]
["YLR401C","DUS3",85666121,35,7,0,0,"zf-CCCH~Dus","NA","cellular organisms","Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region"]
["YMR196W","YMR196W",6323852,35,10,1,0,"NA","NA","cellular organisms","NA"]
["YNL130C","CPT1",42742307,35,8,0,0,"CDP-OH_P_transf","2.7.8.2_Diacylglycerol cholinephosphotransferase","cellular organisms","Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription"]
["YNR053C","NOG2",6324381,35,4,0,0,"NGP1NT~MMR_HSR1~MMR_HSR1","NA","cellular organisms","Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation"]
["YPL198W","RPL7B",6325058,35,12,0,0,"Ribosomal_L30_N~Ribosomal_L30","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)"]
["YPL219W","PCL8",6325037,35,10,0,0,"Cyclin","NA","Eukaryota","Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation"]
["YPR055W","SEC8",6325312,35,8,0,0,"Sec8_exocyst~CDC13-DNA-bind","NA","Fungi/Metazoa group","Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"]
["YPR200C","ARR2",6325458,35,10,0,0,"Rhodanese","NA","Eukaryota","Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p"]
["YAL044C","GCV3",37362609,35,8,0,1,"GCV_H","NA","cellular organisms","H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm"]
["YJL147C","YJL147C",6322314,35,10,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YJR111C","YJR111C",6322571,35,23,1,1,"CMD","NA","cellular organisms","NA"]
["YKL194C","MST1",6322654,35,13,0,1,"tRNA-synt_2b~HGTP_anticodon","6.1.1.3_Threonine--tRNA ligase","cellular organisms","Mitochondrial threonyl-tRNA synthetase"]
["YPR100W","MRPL51",6325356,35,12,0,1,"L51_S25_CI-B8","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit"]
["YAL047C","SPC72",6319269,34,17,0,0,"NA","NA","Saccharomycetaceae","Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization"]
["YBL056W","PTC3",6319415,34,13,0,0,"PP2C","NA","Eukaryota","Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation"]
["YBR033W","EDS1",6319507,34,5,1,0,"Zn_clus","NA","Saccharomycetaceae","Putative zinc cluster protein; YBR033W is not an essential gene"]
["YBR067C","TIP1",6319541,34,3,0,0,"SRP1_TIP1","NA","Saccharomycetales","Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins"]
["YBR184W","YBR184W",6319661,34,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDR242W","AMD2",6320448,34,5,0,0,"Amidase","3.5.1.4_Amidase","cellular organisms","Putative amidase"]
["YDR503C","LPP1",6320711,34,7,0,0,"PAP2","3.1.3.4_Phosphatidate phosphatase","Eukaryota","Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA"]
["YER175C","TMT1",6321023,34,4,0,0,"Methyltransf_4~Methyltransf_11~Methyltransf_12","2.1.1.145_Trans-aconitate 3-methyltransferase","cellular organisms","Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle"]
["YFL048C","EMP47",14318471,34,13,0,0,"Lectin_leg-like","NA","Fungi/Metazoa group","Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"]
["YFR045W","YFR045W",144228167,34,7,1,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","NA"]
["YHL012W","YHL012W",6321775,34,11,1,0,"UDPGP","NA","cellular organisms","NA"]
["YHR015W","MIP6",6321803,34,5,0,0,"RRM_1~RRM_1~RRM_1","NA","Eukaryota","Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export"]
["YIL071C","PCI8",13432314,34,4,0,0,"NA","NA","Saccharomycetaceae","Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain"]
["YJL048C","UBX6",6322413,34,9,0,0,"UBX","NA","Fungi/Metazoa group","UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline"]
["YJL187C","SWE1",6322274,34,16,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate"]
["YJR106W","ECM27",6322566,34,2,0,0,"Na_Ca_ex~Na_Ca_ex","NA","Eukaryota","Non-essential protein of unknown function"]
["YMR118C","YMR118C",6323765,34,7,1,0,"Sdh_cyt","NA","cellular organisms","NA"]
["YNL034W","YNL034W",6324294,34,7,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YNR064C","YNR064C",6324392,34,7,0,0,"Abhydrolase_1","NA","cellular organisms","NA"]
["YOR097C","YOR097C",6324671,34,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR267C","HRK1",6324841,34,23,0,0,"Pkinase~Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis"]
["YOR298W","MUM3",6324872,34,9,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases"]
["YPL140C","MKK2",6325117,34,17,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.12.2_Mitogen-activated protein kinase kinase","cellular organisms","Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p"]
["YPL246C","RBD2",6325010,34,12,0,0,"Rhomboid","NA","cellular organisms","Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p"]
["YPL269W","KAR9",6324986,34,24,0,0,"KAR9","NA","Saccharomycetales","Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase"]
["YPR196W","YPR196W",6325454,34,5,1,0,"Zn_clus~Fungal_trans","NA","Ascomycota","NA"]
["YBL038W","MRPL16",6319433,34,17,0,1,"Ribosomal_L16","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YDL157C","YDL157C",6320044,34,8,1,1,"NA","NA","Saccharomycetales","NA"]
["YFR049W","YMR31",14318574,34,12,0,1,"NA","NA","Ascomycota","Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36"]
["YGR021W","YGR021W",6321458,34,2,1,1,"DUF28","NA","cellular organisms","NA"]
["YHL038C","CBP2",6321749,34,12,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene"]
["YPR001W","CIT3",6325257,34,11,0,1,"Citrate_synt","NA","cellular organisms","Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate"]
["YPR191W","QCR2",6325449,34,6,0,1,"Peptidase_M16~Peptidase_M16_C","NA","cellular organisms","Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme"]
["YAL064C-A","YAL064C-A",7839146,33,3,1,0,"PA14~PA14_2","NA","Saccharomyces","NA"]
["YBR286W","APE3",82795241,33,21,0,0,"PA~Peptidase_M28","3.4.11.15_Aminopeptidase Y","cellular organisms","Vacuolar aminopeptidase Y, processed to mature form by Prb1p"]
["YDL078C","MDH3",6320125,33,7,0,0,"Ldh_1_N~Semialdhyde_dh~Ldh_1_C","1.1.1.37_Malate dehydrogenase","cellular organisms","Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle"]
["YDL183C","YDL183C",6320018,33,18,1,0,"DUF2343","NA","Eukaryota","NA"]
["YDR001C","NTH1",6320204,33,11,0,0,"Trehalase_Ca-bi~Trehalase","3.2.1.28_Alpha,alpha-trehalase","cellular organisms","Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p"]
["YDR411C","DFM1",6320619,33,7,0,0,"DER1","NA","Eukaryota","ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes"]
["YDR488C","PAC11",6320696,33,16,0,0,"WD40","NA","Eukaryota","Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8"]
["YER005W","YND1",6320841,33,19,0,0,"GDA1_CD39","3.6.1.5_Apyrase","cellular organisms","Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p"]
["YER166W","DNF1",6321014,33,14,0,0,"E1-E2_ATPase~Hydrolase_3","3.6.3.1_Phospholipid-translocating ATPase","cellular organisms","Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase"]
["YFR013W","IOC3",14318535,33,17,0,0,"NA","NA","Saccharomycetales","Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing"]
["YHR041C","SRB2",6321831,33,21,0,0,"TATA_RF","NA","Saccharomycetales","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance"]
["YIL013C","PDR11",6322177,33,16,0,0,"ABC_tran~ABC2_membrane~PDR_CDR~DUF258~ABC_tran~ABC2_membrane~PDR_CDR","NA","cellular organisms","ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth"]
["YJL092W","SRS2",6322369,33,21,0,0,"UvrD-helicase","NA","cellular organisms","DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination"]
["YJL138C","TIF2",6322323,33,16,0,0,"DEAD~Helicase_C","NA","cellular organisms","Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G"]
["YKL193C","SDS22",6322655,33,6,0,0,"NA","NA","cellular organisms","Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis"]
["YKR018C","YKR018C",6322870,33,8,1,0,"Deme6","NA","Eukaryota","NA"]
["YKR030W","GMH1",6322882,33,10,0,0,"UNC-50","NA","Eukaryota","Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting"]
["YLR173W","YLR173W",6323202,33,18,1,0,"NA","NA","Ascomycota","NA"]
["YLR270W","DCS1",6323299,33,7,0,0,"DcpS","NA","Eukaryota","Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p"]
["YMR020W","FMS1",6323662,33,4,0,0,"AlaDh_PNT_C~FAD_binding_3~DAO~Pyr_redox_2~FAD_binding_2~Amino_oxidase~Pyr_redox~HI0933_like","1.5.3.11_Polyamine oxidase","cellular organisms","Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis"]
["YMR150C","IMP1",6323800,33,14,0,0,"Peptidase_S24","NA","cellular organisms","Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"]
["YMR152W","YIM1",6323801,33,19,0,0,"ADH_N~ADH_zinc_N","NA","cellular organisms","Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YMR238W","DFG5",6323894,33,29,0,0,"Glyco_hydro_76","3.2.1.101_Mannan endo-1,6-alpha-mannosidase","cellular organisms","Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p"]
["YNL098C","RAS2",6324231,33,12,0,0,"Miro~Ras","NA","cellular organisms","GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes"]
["YOR094W","ARF3",6324668,33,8,0,0,"Arf~Miro","NA","cellular organisms","Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity"]
["YOR223W","YOR223W",6324797,33,15,1,0,"DUF2407","NA","Dikarya","NA"]
["YOR339C","UBC11",6324915,33,10,0,0,"UQ_con","NA","Eukaryota","Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2"]
["YPL058C","PDR12",6325199,33,4,0,0,"ABC_tran~ABC2_membrane~PDR_CDR~DUF258~ABC_tran~cobW~ABC2_membrane~PDR_CDR","NA","cellular organisms","Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity"]
["YDR511W","ACN9",6320719,33,2,0,1,"ACN9","NA","Eukaryota","Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes"]
["YOR176W","HEM15",6324750,33,7,0,1,"Ferrochelatase","4.99.1.1_Ferrochelatase","cellular organisms","Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway"]
["YBR297W","MAL33",6319774,32,11,0,0,"Zn_clus~Fungal_trans","NA","Ascomycota","MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C"]
["YDL020C","RPN4",6320184,32,18,0,0,"zf-C2H2","NA","Saccharomycetaceae","Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses"]
["YDR432W","NPL3",6320640,32,21,0,0,"RRM_1~RRM_1","NA","Eukaryota","RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm"]
["YEL015W","EDC3",6320822,32,10,0,0,"DFDF","NA","cellular organisms","Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies"]
["YFL021W","GAT1",14318498,32,6,0,0,"GATA","NA","Fungi/Metazoa group","Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p"]
["YGL249W","ZIP2",6321188,32,7,0,0,"NA","NA","Saccharomycetaceae","Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis"]
["YGL257C","MNT2",6321180,32,9,0,0,"NA","NA","Ascomycota","Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans"]
["YGR079W","YGR079W",6321516,32,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGR169C","PUS6",6321608,32,4,0,0,"PseudoU_synth_2","NA","cellular organisms","Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability"]
["YHL047C","ARN2",6321740,32,13,0,0,"MFS_1~MFS_1","NA","cellular organisms","Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C"]
["YHR016C","YSC84",6321804,32,5,0,0,"DUF500~SH3_1~SH3_2","NA","cellular organisms","Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p"]
["YIL016W","SNL1",6322173,32,19,0,0,"BAG","NA","Saccharomycetaceae","Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein"]
["YIL029C","YIL029C",6322160,32,26,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YJL073W","JEM1",6322388,32,24,0,0,"DnaJ","NA","Fungi/Metazoa group","DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2"]
["YJL089W","SIP4",6322372,32,5,0,0,"Zn_clus","NA","Saccharomycetaceae","C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus"]
["YJL139C","YUR1",6322322,32,19,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus"]
["YJR066W","TOR1",6322526,32,16,0,0,"HEAT~FAT~Rapamycin_bind~PI3_PI4_kinase~FATC","2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis"]
["YJR119C","JHD2",6322579,32,9,0,0,"JmjN~PHD~JmjC","NA","Eukaryota","JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase"]
["YKL061W","YKL061W",6322789,32,12,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKL197C","PEX1",6322651,32,14,0,0,"PEX-1N~Arch_ATPase~AAA~AAA_3~Mg_chelatase","NA","cellular organisms","AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis"]
["YLR414C","YLR414C",6323446,32,30,1,0,"SUR7","NA","Ascomycota","NA"]
["YMR227C","TAF7",6323883,32,5,0,0,"TAFII55_N","NA","Fungi/Metazoa group","TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation"]
["YOL024W","YOL024W",6324549,32,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOL098C","YOL098C",6324474,32,7,1,0,"Peptidase_M16~Peptidase_M16_C","NA","cellular organisms","NA"]
["YOR049C","RSB1",6324623,32,10,0,0,"RTA1","NA","Eukaryota","Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane"]
["YOR261C","RPN8",6324835,32,10,0,0,"Mov34","NA","Eukaryota","Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p"]
["YOR313C","SPS4",6324889,32,10,0,0,"NA","NA","Saccharomycetales","Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage"]
["YOR332W","VMA4",6324907,32,24,0,0,"vATP-synt_E","NA","cellular organisms","Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"]
["YPL006W","NCR1",6325251,32,10,0,0,"Patched","NA","Eukaryota","Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein"]
["YPL216W","YPL216W",6325040,32,6,1,0,"WAC_Acf1_DNA_bd~DDT","NA","Ascomycota","NA"]
["YHL014C","YLF2",6321773,32,19,0,1,"MMR_HSR1~YchF-GTPase_C","NA","cellular organisms","Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YJL200C","ACO2",6322261,32,9,0,1,"Aconitase~Aconitase_C","NA","cellular organisms","Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol"]
["YBL036C","YBL036C",6319435,31,10,0,0,"Ala_racemase_N","NA","cellular organisms","NA"]
["YBR111C","YSA1",6319587,31,7,0,0,"NUDIX","3.6.1.13_ADP-ribose diphosphatase","cellular organisms","Nudix hydrolase family member with ADP-ribose pyrophosphatase activity"]
["YBR127C","VMA2",6319603,31,21,0,0,"ATP-synt_ab_N~ATP-synt_ab~ATP-synt_ab_C","NA","cellular organisms","Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm"]
["YBR181C","RPS6B",6319658,31,9,0,0,"Ribosomal_S6e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein"]
["YCL038C","ATG22",6319811,31,8,0,0,"NA","NA","cellular organisms","Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation"]
["YCR077C","PAT1",10383807,31,14,0,0,"PAT1","NA","Dikarya","Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p"]
["YDL095W","PMT1",6320107,31,17,0,0,"PMT~MIR","2.4.1.109_Dolichyl-phosphate-mannose-protein mannosyltransferase","cellular organisms","Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals"]
["YDR068W","DOS2",6320273,31,6,0,0,"BSD","NA","Eukaryota","Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"]
["YDR330W","UBX5",6320537,31,8,0,0,"UBX","NA","Eukaryota","UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p"]
["YDR436W","PPZ2",6320644,31,14,0,0,"Metallophos","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance"]
["YDR512C","EMI1",6320721,31,13,0,0,"NA","NA","Dikarya","Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation"]
["YER042W","MXR1",6320881,31,5,0,0,"PMSR","1.8.4.11_Peptide-methionine (S)-S-oxide reductase","cellular organisms","Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan"]
["YGL156W","AMS1",6321282,31,7,0,0,"Glyco_hydro_38~Alpha-mann_mid~Glyco_hydro_38C","3.2.1.24_Alpha-mannosidase","cellular organisms","Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway"]
["YGR210C","YGR210C",6321649,31,5,1,0,"MMR_HSR1~MMR_HSR1_C","NA","cellular organisms","NA"]
["YGR238C","KEL2",6321677,31,5,0,0,"Kelch_1~Kelch_2~Kelch_1~Kelch_2","NA","cellular organisms","Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate"]
["YIR014W","YIR014W",37362663,31,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YJR091C","JSN1",6322550,31,9,0,0,"RRM_1~PUF~PUF~PUF~PUF","NA","Dikarya","Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells"]
["YKL166C","TPK3",6322682,31,6,0,0,"Pkinase~Pkinase_Tyr~YrbL-PhoP_reg~Pkinase_Tyr","2.7.11.11_cAMP-dependent protein kinase","cellular organisms","cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p"]
["YMR105C","PGM2",6323752,31,7,0,0,"PGM_PMM_I~PGM_PMM_II~PGM_PMM_III~PGM_PMM_IV","5.4.2.2_Phosphoglucomutase","cellular organisms","Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase"]
["YMR174C","PAI3",6323828,31,10,0,0,"Inhibitor_I34","NA","Saccharomyces cerevisiae","Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact"]
["YNL095C","YNL095C",6324234,31,10,1,0,"Mem_trans","NA","Dikarya","NA"]
["YNL194C","YNL194C",6324135,31,7,0,0,"SUR7","NA","Ascomycota","NA"]
["YNR039C","ZRG17",6324367,31,10,0,0,"NA","NA","Ascomycota","Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc"]
["YOR042W","CUE5",6324615,31,18,0,0,"CUE","NA","Ascomycota","Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YOR254C","SEC63",6324828,31,6,0,0,"DnaJ~Sec63","NA","cellular organisms","Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"]
["YPL116W","HOS3",6325141,31,7,0,0,"Hist_deacetyl","3.5.1.98_Histone deacetylase","cellular organisms","Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats"]
["YHR003C","YHR003C",6321790,31,8,0,1,"Shikimate_DH~ThiF","NA","cellular organisms","NA"]
["YJL071W","ARG2",6322390,31,12,0,1,"DUF619","NA","cellular organisms","Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p"]
["YMR097C","MTG1",6323744,31,7,0,1,"MMR_HSR1","NA","cellular organisms","Peripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals"]
["YMR293C","LRC6",6323950,31,11,0,1,"Amidase","NA","cellular organisms","Putative protein similar to bacterial glutamyl-tRNA amidotransferases; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YOR374W","ALD4",6324950,31,11,0,1,"Aldedh","NA","cellular organisms","Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed"]
["YAL037W","YAL037W",6319280,30,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBL055C","YBL055C",6319416,30,7,0,0,"TatD_DNase","NA","cellular organisms","NA"]
["YBL091C","MAP2",6319380,30,7,0,0,"Peptidase_M24","NA","cellular organisms","Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p"]
["YBR284W","YBR284W",6319761,30,17,1,0,"A_deaminase~A_deaminase~A_deaminase","NA","Eukaryota","NA"]
["YBR294W","SUL1",6319771,30,7,0,0,"Sulfate_transp~STAS","NA","cellular organisms","High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates"]
["YBR296C","PHO89",6319773,30,8,0,0,"PHO4","NA","cellular organisms","Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p"]
["YCR059C","YIH1",6319904,30,11,0,0,"RWD~UPF0029","NA","cellular organisms","Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene"]
["YDL088C","ASM4",6320115,30,5,0,0,"MPPN","NA","Saccharomycetales","Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p"]
["YDR129C","SAC6",6320334,30,24,0,0,"CH~CH~CH~CH","NA","Eukaryota","Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton"]
["YDR206W","EBS1",6320412,30,5,0,0,"EST1~EST1_DNA_bind","NA","Ascomycota","Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors"]
["YDR273W","DON1",6320479,30,6,0,0,"CUE","NA","Saccharomyces cerevisiae","Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II"]
["YER070W","RNR1",6320914,30,10,0,0,"ATP-cone~Ribonuc_red_lgN~Ribonuc_red_lgC","1.17.4.1_Ribonucleoside-diphosphate reductase","cellular organisms","One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits"]
["YGR276C","RNH70",6321715,30,5,0,0,"Exonuc_X-T","NA","Eukaryota","3' exoribonuclease, required for 5S rRNA and tRNA-Arg3 maturation"]
["YHL046C","PAU13",6321741,30,12,1,0,"SRP1_TIP1","NA","Saccharomycetaceae","Putative protein of unknown function; not an essential gene"]
["YHR060W","VMA22",6321851,30,28,0,0,"NA","NA","Ascomycota","Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)"]
["YIL110W","MNI1",6322081,30,5,1,0,"NA","NA","Eukaryota","Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants"]
["YJL023C","PET130",6322438,30,17,0,0,"NA","NA","Saccharomycetaceae","Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YJL045W","YJL045W",6322416,30,5,1,0,"Thi4~FAD_binding_2~Pyr_redox_2~Succ_DH_flav_C","1.3.5.1_Succinate dehydrogenase (ubiquinone)","cellular organisms","NA"]
["YKL101W","HSL1",6322748,30,24,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p"]
["YKR076W","ECM4",6322929,30,9,0,0,"NA","2.5.1.18_Glutathione transferase","cellular organisms","Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"]
["YLR094C","GIS3",6323123,30,15,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function"]
["YLR319C","BUD6",6323351,30,17,0,0,"AIP3","NA","Dikarya","Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate"]
["YLR461W","PAU4",6323494,30,10,0,0,"SRP1_TIP1","NA","Saccharomycetaceae","Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"]
["YOL025W","LAG2",6324548,30,7,0,0,"NA","NA","Saccharomycetaceae","Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells"]
["YOL107W","YOL107W",6324465,30,9,1,0,"DUF1751","NA","Eukaryota","NA"]
["YPL043W","NOP4",6325213,30,6,0,0,"RRM_1~RRM_1~RRM_1~RRM_1","NA","Eukaryota","Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)"]
["YPL247C","YPL247C",6325009,30,9,1,0,"WD40~WD40","NA","Eukaryota","NA"]
["YPR138C","MEP3",6325396,30,8,0,0,"Ammonium_transp","NA","cellular organisms","Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease"]
["YBL095W","YBL095W",6319374,30,12,1,1,"NA","NA","cellular organisms","NA"]
["YLR091W","YLR091W",6323120,30,5,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YNL070W","TOM7",6324259,30,43,0,1,"Tom7","NA","Dikarya","Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex"]
["YPL040C","ISM1",6325217,30,14,0,1,"tRNA-synt_1~tRNA-synt_1g~tRNA-synt_1~tRNA-synt_1~tRNA-synt_1g~Anticodon_1~zf-FPG_IleRS","6.1.1.5_Isoleucine--tRNA ligase","cellular organisms","Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth"]
["YPL078C","ATP4",6325179,30,16,0,1,"Mt_ATP-synt_B","NA","Fungi/Metazoa group","Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"]
["YBR034C","HMT1",6319508,29,12,0,0,"MTS~Methyltransf_9~PrmA~Methyltransf_11~Methyltransf_12","NA","cellular organisms","Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants"]
["YCL040W","GLK1",6319809,29,3,0,0,"Hexokinase_1~Hexokinase_2","2.7.1.2_Glucokinase","cellular organisms","Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources"]
["YCR082W","AHC2",6319924,29,12,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus"]
["YDL203C","ACK1",6319998,29,15,0,0,"Sel1~Sel1~Sel1","NA","cellular organisms","Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria"]
["YDL209C","CWC2",6319992,29,2,0,0,"RRM_1","NA","Eukaryota","Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p"]
["YDR304C","CPR5",6320510,29,7,0,0,"Pro_isomerase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER"]
["YEL002C","WBP1",6320835,29,5,0,0,"DDOST_48kD","2.4.1.119_Dolichyl-diphosphooligosaccharide--protein glycotransferase","Eukaryota","Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum"]
["YER134C","YER134C",6320981,29,6,1,0,"NA","NA","Eukaryota","NA"]
["YGR093W","DRN1",6321530,29,6,1,0,"CwfJ_C_1~CwfJ_C_2","NA","Eukaryota","Putative debranching enzyme associated ribonuclease; green fluorescent protein (GFP)-fusion protein localizes to the nucleus"]
["YGR203W","YGR203W",6321642,29,6,1,0,"NA","NA","Eukaryota","NA"]
["YGR268C","HUA1",6321708,29,15,0,0,"NA","NA","Ascomycota","Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly"]
["YGR288W","MAL13",6321727,29,9,0,0,"Zn_clus~Fungal_trans","NA","Ascomycota","MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C"]
["YHR018C","ARG4",6321806,29,8,0,0,"Lyase_1","4.3.2.1_Argininosuccinate lyase","cellular organisms","Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway"]
["YHR123W","EPT1",6321915,29,17,0,0,"CDP-OH_P_transf","2.7.8.1_Ethanolaminephosphotransferase|2.7.8.2_Diacylglycerol cholinephosphotransferase","cellular organisms","sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability"]
["YHR150W","PEX28",6321944,29,4,0,0,"Pex24p","NA","Ascomycota","Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p"]
["YJL216C","YJL216C",6322245,29,10,1,0,"Alpha-amylase","NA","cellular organisms","NA"]
["YKL057C","NUP120",6322793,29,12,0,0,"NA","NA","Saccharomycetaceae","Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p"]
["YKL087C","CYT2",6322763,29,11,0,0,"Cyto_heme_lyase","NA","Eukaryota","Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1"]
["YKR046C","PET10",6322899,29,10,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange"]
["YLL012W","YEH1",6323017,29,8,0,0,"Abhydro_lipase","3.1.1.13_Sterol esterase","cellular organisms","Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes"]
["YLL035W","GRC3",6322993,29,7,0,0,"NA","NA","Eukaryota","Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated"]
["YLR032W","RAD5",6323060,29,20,0,0,"HIRAN~SNF2_N~zf-C3HC4~Helicase_C","NA","cellular organisms","DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain"]
["YLR108C","YLR108C",6323137,29,8,1,0,"NA","NA","Ascomycota","NA"]
["YLR191W","PEX13",6323220,29,20,0,0,"Peroxin-13_N~SH3_1","NA","Fungi/Metazoa group","Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p"]
["YLR254C","NDL1",6323283,29,11,0,0,"bZIP_2~bZIP_1","NA","Saccharomycetaceae","Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends"]
["YML029W","USA1",6323612,29,11,0,0,"ubiquitin","NA","Saccharomycetaceae","Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p"]
["YML118W","NGL3",6323517,29,5,0,0,"Exo_endo_phos","NA","cellular organisms","Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p"]
["YMR162C","DNF3",6323814,29,7,0,0,"E1-E2_ATPase~Hydrolase~Hydrolase_3","3.6.3.1_Phospholipid-translocating ATPase","cellular organisms","Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase"]
["YMR221C","FMP42",6323877,29,11,1,0,"MFS_1~MFS_1","NA","Eukaryota","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy"]
["YMR305C","SCW10",6323964,29,10,0,0,"Glyco_hydro_17","NA","cellular organisms","Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p"]
["YNL051W","COG5",6324277,29,18,0,0,"COG5","NA","Ascomycota","Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YNL135C","FPR1",6324194,29,5,0,0,"FKBP_C","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function"]
["YNL283C","WSC2",6324046,29,32,0,0,"WSC~SKG6","NA","Ascomycota","Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response"]
["YOR011W","AUS1",6324585,29,10,0,0,"ABC_tran~ABC2_membrane~PDR_CDR~DUF258~ABC_tran~ABC2_membrane~PDR_CDR","NA","cellular organisms","Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth"]
["YOR027W","STI1",6324601,29,20,0,0,"TPR_1~TPR_2~TPR_1~TPR_1~TPR_2~TPR_1~TPR_1~TPR_1~TPR_2","NA","cellular organisms","Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein"]
["YOR109W","INP53",6324683,29,22,0,0,"Syja_N~Exo_endo_phos","NA","Eukaryota","Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains"]
["YOR268C","YOR268C",6324842,29,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YOR276W","CAF20",6324850,29,7,0,0,"NA","NA","Saccharomycetales","Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E"]
["YGR028W","MSP1",6321465,29,5,0,1,"Rad17~AAA_2~IstB~Parvo_NS1~AAA~AAA_3~AAA_5~NACHT~ATP-synt_ab~Mg_chelatase","NA","cellular organisms","Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase"]
["YMR059W","SEN15",99030929,29,2,0,1,"NA","NA","Saccharomycetales","Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p"]
["YNL052W","COX5A",6324276,29,7,0,1,"COX4","NA","Fungi/Metazoa group","Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth"]
["YPL060W","LPE10",6325197,29,12,0,1,"CorA","NA","Eukaryota","Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p"]
["YBR137W","YBR137W",6319613,28,6,1,0,"DUF336","NA","cellular organisms","NA"]
["YBR244W","GPX2",6319721,28,24,0,0,"Redoxin~GSHPx","1.11.1.9_Glutathione peroxidase","cellular organisms","Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress"]
["YCL011C","GBP2",6319835,28,5,0,0,"RRM_1~RRM_1~RRM_1","NA","cellular organisms","Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro"]
["YDL211C","YDL211C",6319990,28,16,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDL219W","DTD1",6319982,28,5,0,0,"Tyr_Deacylase","NA","cellular organisms","D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes"]
["YDR419W","RAD30",6320627,28,2,0,0,"IMS~DUF1805","2.7.7.7_DNA-directed DNA polymerase","cellular organisms","DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins"]
["YEL044W","IES6",6320791,28,15,0,0,"YL1_C","NA","Eukaryota","Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions"]
["YER151C","UBP3",6320999,28,18,0,0,"UCH","3.1.2.15_Ubiquitin thiolesterase","Eukaryota","Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin"]
["YGL027C","CWH41",6321411,28,18,0,0,"Glyco_hydro_63","NA","cellular organisms","Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress"]
["YGL056C","SDS23",6321382,28,9,0,0,"CBS~CBS~CBS","NA","Eukaryota","One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation"]
["YGR043C","NQM1",6321480,28,5,0,0,"Transaldolase","2.2.1.2_Transaldolase","cellular organisms","Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity"]
["YHL022C","SPO11",6321765,28,14,0,0,"TP6A_N","NA","cellular organisms","Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation"]
["YHL026C","YHL026C",82795253,28,9,1,0,"DUF2456","NA","Ascomycota","NA"]
["YHR028C","DAP2",6321817,28,14,0,0,"DPPIV_N~Peptidase_S9","NA","cellular organisms","Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p"]
["YIL145C","PAN6",37362661,28,7,0,0,"Pantoate_ligase","6.3.2.1_Pantoate--beta-alanine ligase","cellular organisms","Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC"]
["YJL103C","GSM1",6322358,28,4,1,0,"Zn_clus","NA","Dikarya","Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis"]
["YJL191W","RPS14B",6322270,28,5,0,0,"Ribosomal_S11","NA","cellular organisms","Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins"]
["YKL071W","YKL071W",6322779,28,9,1,0,"NA","NA","cellular organisms","NA"]
["YKR009C","FOX2",6322861,28,5,0,0,"adh_short~KR~adh_short~adh_short~KR~MaoC_dehydratas","NA","cellular organisms","Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities"]
["YLL023C","YLL023C",6323005,28,10,0,0,"NA","NA","Eukaryota","NA"]
["YLR061W","RPL22A",6323090,28,6,0,0,"Ribosomal_L22e","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein"]
["YNL313C","YNL313C",6324016,28,6,1,0,"NA","NA","Eukaryota","NA"]
["YNR062C","YNR062C",6324390,28,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOL028C","YAP7",6324545,28,8,0,0,"Hap4_Hap_bind~bZIP_1","NA","Saccharomycetaceae","Putative basic leucine zipper (bZIP) transcription factor"]
["YOR190W","SPR1",6324764,28,5,0,0,"Cellulase","3.2.1.58_Glucan 1,3-beta-glucosidase","cellular organisms","Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance"]
["YOR296W","YOR296W",6324870,28,12,1,0,"C2~Membr_traf_MHD","NA","Dikarya","NA"]
["YPL166W","ATG29",6325091,28,12,0,0,"NA","NA","Saccharomycetaceae","Protein specifically required for autophagy; may function in autophagosome formation at the pre-autophagosomal structure in collaboration with other autophagy proteins"]
["YPL192C","PRM3",6325064,28,11,0,0,"NA","NA","Saccharomyces cerevisiae","Pheromone-regulated protein required for karyogamy; localizes to the inner membrane of the nuclear envelope"]
["YBL059W","YBL059W",6319412,28,7,1,1,"NA","NA","Saccharomycetales","NA"]
["YIR021W","MRS1",6322212,28,11,0,1,"NA","NA","Saccharomycetaceae","Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA"]
["YAR023C","YAR023C",6319330,27,5,1,0,"DUP","NA","Saccharomyces cerevisiae","NA"]
["YBL005W","PDR3",6319466,27,11,0,0,"Zn_clus~Fungal_trans","NA","Saccharomycetaceae","Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)"]
["YBL028C","YBL028C",6319443,27,6,0,0,"DUF2423","NA","Dikarya","NA"]
["YBR149W","ARA1",6319625,27,5,0,0,"Aldo_ket_red","1.1.1.117_D-arabinose 1-dehydrogenase (NAD(P)(+))","cellular organisms","NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product"]
["YCR087C-A","LUG1",6319930,27,13,1,0,"zf-LYAR","NA","Eukaryota","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene"]
["YDL053C","PBP4",6320150,27,11,0,0,"NA","NA","Saccharomycetaceae","Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay"]
["YDL154W","MSH5",6320047,27,6,0,0,"MutS_III~MutS_V~MutS_V","NA","cellular organisms","Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans"]
["YDL213C","NOP6",6319988,27,12,0,0,"NA","NA","Eukaryota","Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes"]
["YDR263C","DIN7",6320469,27,5,0,0,"XPG_N~XPG_I","NA","cellular organisms","Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination"]
["YDR358W","GGA1",6320565,27,17,0,0,"VHS~Alpha_adaptinC2","NA","Eukaryota","Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi"]
["YER022W","SRB4",6320860,27,17,0,0,"NA","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YER065C","ICL1",6320908,27,6,0,0,"ICL","4.1.3.1_Isocitrate lyase","cellular organisms","Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose"]
["YER089C","PTC2",6320934,27,12,0,0,"PP2C","NA","Eukaryota","Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation"]
["YGL163C","RAD54",6321275,27,19,0,0,"Rad54_N~SNF2_N~Helicase_C","NA","cellular organisms","DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family"]
["YGL216W","KIP3",6321221,27,11,0,0,"Kinesin","NA","Eukaryota","Kinesin-related motor protein involved in mitotic spindle positioning"]
["YGR159C","NSR1",6321599,27,8,0,0,"DUF270~RRM_1~RRM_1","NA","cellular organisms","Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis"]
["YHL031C","GOS1",6321756,27,18,0,0,"V-SNARE","NA","Eukaryota","v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28"]
["YHR131C","YHR131C",50882584,27,14,1,0,"PH","NA","Saccharomycetales","NA"]
["YHR210C","YHR210C",6322004,27,16,1,0,"Aldose_epim","NA","cellular organisms","NA"]
["YIL065C","FIS1",6322124,27,47,0,0,"NA","NA","Eukaryota","Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation"]
["YIL120W","QDR1",6322071,27,6,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban"]
["YIR017C","MET28",6322207,27,7,0,0,"bZIP_2","NA","Saccharomycetales","Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism"]
["YJL196C","ELO1",6322265,27,3,0,0,"ELO","NA","Eukaryota","Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids"]
["YKL142W","MRP8",6322707,27,5,0,0,"Ribosomal_MRP8","NA","Saccharomycetales","Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2"]
["YKL175W","ZRT3",6322673,27,10,0,0,"Zip","NA","cellular organisms","Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency"]
["YKR090W","PXL1",6322943,27,12,0,0,"LIM~LIM","NA","Fungi/Metazoa group","LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin"]
["YLL025W","PAU17",6323003,27,7,1,0,"SRP1_TIP1","NA","Saccharomycetaceae","Putative protein of unknown function; YLL025W is not an essential gene"]
["YLR028C","ADE16",6323056,27,8,0,0,"MGS~AICARFT_IMPCHas","NA","cellular organisms","Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine"]
["YLR046C","YLR046C",6323075,27,13,1,0,"RTA1","NA","Eukaryota","NA"]
["YML101C","CUE4",6323536,27,6,0,0,"CUE","NA","Saccharomycetaceae","Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination"]
["YMR246W","FAA4",6323903,27,10,0,0,"AMP-binding~AMP-binding","6.2.1.3_Long-chain-fatty-acid--CoA ligase","cellular organisms","Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids"]
["YNL244C","SUI1",6324085,27,2,0,0,"SUI1","NA","cellular organisms","Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase"]
["YNL279W","PRM1",6324050,27,8,0,0,"NA","NA","Dikarya","Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p"]
["YOL097C","WRS1",6324475,27,2,0,0,"tRNA-synt_1b~tRNA-synt_1b","6.1.1.2_Tryptophan--tRNA ligase","cellular organisms","Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA"]
["YPL007C","TFC8",6325250,27,4,0,0,"NA","NA","Saccharomycetales","One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90"]
["YPL046C","ELC1",6325211,27,15,0,0,"Skp1_POZ","NA","Eukaryota","Elongin C, forms heterodimer with Ela1p that participates in transcription elongation; required for ubiquitin-dependent degradation of the RNA Polymerase II subunit RPO21; expression dramatically upregulated during sporulation"]
["YBR047W","FMP23",6319521,27,3,1,1,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YGR033C","TIM21",6321470,27,7,0,1,"TIM21","NA","Fungi/Metazoa group","Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes"]
["YPR155C","NCA2",6325413,27,11,0,1,"NCA2","NA","Eukaryota","Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p"]
["YBL104C","YBL104C",41629671,26,19,1,0,"NA","NA","Eukaryota","NA"]
["YBL107C","YBL107C",6319361,26,5,1,0,"Cid2","NA","Ascomycota","NA"]
["YBR128C","ATG14",6319604,26,13,0,0,"NA","NA","Saccharomycetaceae","Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34p, Vps15p, and Vps30p); Atg14p targets complex I to the pre-autophagosomal structure (PAS); required for localizing additional ATG proteins to the PAS"]
["YBR139W","YBR139W",6319615,26,4,0,0,"Peptidase_S10","NA","cellular organisms","NA"]
["YBR272C","HSM3",6319749,26,5,0,0,"NA","NA","Saccharomycetales","Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p"]
["YCR010C","ADY2",6319855,26,5,0,0,"Grp1_Fun34_YaaH~C4dic_mal_tran","NA","cellular organisms","Acetate transporter required for normal sporulation; phosphorylated in mitochondria"]
["YCR075C","ERS1",6319919,26,11,0,0,"PQ-loop~PQ-loop","NA","Eukaryota","Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains"]
["YDL149W","ATG9",6320052,26,4,0,0,"APG9","NA","Eukaryota","Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes"]
["YDL205C","HEM3",6319996,26,10,0,0,"Porphobil_deam~Porphobil_deamC","2.5.1.61_Hydroxymethylbilane synthase","cellular organisms","Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p"]
["YDR077W","SED1",6320282,26,8,0,0,"NA","NA","Fungi/Metazoa group","Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites"]
["YDR083W","RRP8",85666115,26,8,0,0,"Methyltransf_8~Methyltransf_11~Methyltransf_8","NA","Eukaryota","Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation"]
["YDR092W","UBC13",6320297,26,4,0,0,"UQ_con~RWD","NA","Eukaryota","Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus"]
["YDR119W","YDR119W",6320324,26,5,1,0,"MFS_1","NA","cellular organisms","Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene"]
["YDR165W","TRM82",6320369,26,11,0,0,"WD40","NA","Eukaryota","Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA"]
["YDR412W","RRP17",6320620,26,8,1,0,"Nop25","NA","Fungi/Metazoa group","Component of the pre-60S pre-ribosomal particle; required for cell viability"]
["YER039C","HVG1",6320877,26,7,0,0,"ET","NA","Eukaryota","Protein of unknown function, has homology to Vrg4p"]
["YER083C","GET2",37362643,26,28,0,0,"GET2","NA","Saccharomycetales","Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function"]
["YGL004C","RPN14",6321434,26,5,0,0,"WD40~WD40","NA","cellular organisms","Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm"]
["YIL138C","TPM2",6322053,26,4,0,0,"NA","NA","Fungi/Metazoa group","Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p"]
["YJL099W","CHS6",6322362,26,13,0,0,"ChAPs~ChAPs~TPR_1~TPR_2~ChAPs","NA","Dikarya","Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"]
["YJL108C","PRM10",6322353,26,5,0,0,"DUF1212","NA","cellular organisms","Pheromone-regulated protein, predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation"]
["YJL110C","GZF3",6322351,26,13,0,0,"GATA","NA","Ascomycota","GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p"]
["YJL164C","TPK1",6322297,26,36,0,0,"Pkinase~Pkinase_Tyr~YrbL-PhoP_reg~Pkinase_Tyr","2.7.11.11_cAMP-dependent protein kinase","cellular organisms","cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p"]
["YJR069C","HAM1",6322529,26,6,0,0,"Ham1p_like","NA","cellular organisms","Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine"]
["YKR020W","VPS51",6322872,26,22,0,0,"Vps51","NA","Saccharomycetaceae","Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p"]
["YKR038C","KAE1",37362674,26,2,0,0,"Peptidase_M22","NA","cellular organisms","Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex"]
["YLR020C","YEH2",6323048,26,21,0,0,"Abhydro_lipase~Abhydrolase_1","3.1.1.13_Sterol esterase","cellular organisms","Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism"]
["YLR031W","YLR031W",6323059,26,8,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR053C","YLR053C",6323082,26,9,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR131C","ACE2",6323160,26,10,0,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate"]
["YLR185W","RPL37A",6323214,26,8,0,0,"Ribosomal_L37e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein"]
["YLR306W","UBC12",6323337,26,9,0,0,"UQ_con","NA","Eukaryota","Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes"]
["YLR309C","IMH1",6323340,26,15,0,0,"GRIP","NA","Dikarya","Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi"]
["YMR036C","MIH1",6323679,26,13,0,0,"Rhodanese","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25"]
["YMR074C","YMR074C",6323719,26,7,1,0,"dsDNA_bind","NA","cellular organisms","NA"]
["YMR143W","RPS16A",9755341,26,8,0,0,"Ribosomal_S9","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins"]
["YMR251W","GTO3",6323906,26,6,0,0,"NA","2.5.1.18_Glutathione transferase","cellular organisms","Omega class glutathione transferase; putative cytosolic localization"]
["YMR279C","YMR279C",6323935,26,15,1,0,"MFS_1~Sugar_tr","NA","cellular organisms","NA"]
["YNL214W","PEX17",6324115,26,15,0,0,"NA","NA","Saccharomycetaceae","Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis"]
["YNL269W","BSC4",6324060,26,10,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p"]
["YNR044W","AGA1",6324372,26,5,0,0,"NA","NA","Fungi/Metazoa group","Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds"]
["YOL089C","HAL9",6324483,26,32,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression"]
["YOL112W","MSB4",6324460,26,2,0,0,"TBC~TBC","NA","Eukaryota","GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization"]
["YOR028C","CIN5",6324602,26,14,0,0,"bZIP_1","NA","Ascomycota","Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus"]
["YOR237W","HES1",6324811,26,7,0,0,"Oxysterol_BP","NA","Eukaryota","Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)"]
["YOR346W","REV1",6324921,26,10,0,0,"BRCT~IMS","NA","cellular organisms","Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA"]
["YPL267W","ACM1",6324988,26,9,0,0,"NA","NA","Saccharomycetaceae","Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins"]
["YPR135W","CTF4",6325393,26,19,0,0,"NA","NA","Eukaryota","Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion"]
["YDR148C","KGD2",6320352,26,12,0,1,"Biotin_lipoyl~2-oxoacid_dh","2.3.1.61_Dihydrolipoyllysine-residue succinyltransferase","cellular organisms","Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated"]
["YML030W","AIM31",6323611,26,6,1,1,"HIG_1_N","NA","Fungi/Metazoa group","Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth rate in minimal glycerol media"]
["YMR157C","AIM36",6323807,26,5,1,1,"NA","NA","Saccharomycetales","Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media"]
["YOR158W","PET123",6324732,26,22,0,1,"NA","NA","Saccharomycetales","Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator"]
["YBL044W","YBL044W",6319427,25,12,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YBL069W","AST1",14270687,25,7,0,0,"ADH_N","NA","cellular organisms","Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts"]
["YBR183W","YPC1",6319660,25,9,0,0,"aPHC","NA","Eukaryota","Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance"]
["YCR020C-A","MAK31",6319867,25,15,0,0,"LSM","NA","Fungi/Metazoa group","Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family"]
["YDL069C","CBS1",37362630,25,3,0,0,"NA","NA","Saccharomyces cerevisiae","Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"]
["YDR317W","HIM1",6320523,25,14,0,0,"HIM1","NA","Saccharomycetaceae","Protein of unknown function involved in DNA repair"]
["YDR409W","SIZ1",6320617,25,8,0,0,"SAP~zf-MIZ","NA","Eukaryota","SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring"]
["YDR534C","FIT1",6320743,25,5,0,0,"NA","NA","Saccharomycetaceae","Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"]
["YER079W","YER079W",6320923,25,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YER150W","SPI1",6320998,25,4,0,0,"NA","NA","Eukaryota","GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p"]
["YGL050W","TYW3",6321388,25,9,0,0,"TYW3","NA","cellular organisms","tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions"]
["YGL158W","RCK1",6321280,25,3,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations"]
["YGL171W","ROK1",6321267,25,2,0,0,"DEAD~Helicase_C","NA","cellular organisms","ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis"]
["YGL235W","YGL235W",6321201,25,9,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGR009C","SEC9",6321446,25,4,0,0,"NA","NA","Fungi/Metazoa group","t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog"]
["YGR124W","ASN2",6321563,25,7,0,0,"Asn_synthase~ExsB","NA","cellular organisms","Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway"]
["YHR006W","STP2",6321794,25,15,0,0,"zf-C2H2","NA","Saccharomycetales","Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes"]
["YHR057C","CPR2",6321848,25,6,0,0,"Pro_isomerase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway"]
["YHR176W","FMO1",41629686,25,8,0,0,"Pyr_redox_2~FMO-like~FMO-like~FMO-like","NA","cellular organisms","Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins"]
["YHR209W","CRG1",6322003,25,10,1,0,"Methyltransf_11~Methyltransf_12","NA","cellular organisms","Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance"]
["YIL044C","AGE2",6322145,25,21,0,0,"ArfGap","NA","Eukaryota","ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif"]
["YJL046W","AIM22",83578101,25,11,1,0,"BPL_LipA_LipB","2.7.7.63_Lipoate--protein ligase","cellular organisms","Putative lipoate-protein ligase A family member; null mutant displays respiratory growth defect, decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YJL181W","YJL181W",6322279,25,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YJR092W","BUD4",46562091,25,9,0,0,"DUF1709~PH","NA","Saccharomycetaceae","Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate"]
["YJR131W","MNS1",6322591,25,5,0,0,"Glyco_hydro_47","3.2.1.113_Mannosyl-oligosaccharide 1,2-alpha-mannosidase","cellular organisms","Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane"]
["YKL004W","AUR1",6322849,25,4,0,0,"PAP2","NA","cellular organisms","Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance"]
["YKL183W","LOT5",6322665,25,7,0,0,"NA","NA","Saccharomycetales","Protein of unknown function; gene expression increases in cultures shifted to a lower temperature"]
["YLR042C","YLR042C",6323071,25,14,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR102C","APC9",6323131,25,10,0,0,"NA","NA","Saccharomycetaceae","Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"]
["YLR119W","SRN2",6323148,25,30,0,0,"Mod_r","NA","Saccharomycetaceae","Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus"]
["YLR183C","TOS4",6323212,25,9,0,0,"FHA","NA","Ascomycota","Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF"]
["YLR320W","MMS22",6323352,25,15,0,0,"Mus7","NA","Saccharomycetaceae","Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation"]
["YLR429W","CRN1",6323460,25,8,0,0,"DUF1899~WD40~WD40~WD40~DUF1900","NA","cellular organisms","Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly"]
["YLR445W","YLR445W",42742290,25,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML042W","CAT2",6323599,25,3,0,0,"Carn_acyltransf","2.3.1.7_Carnitine O-acetyltransferase","cellular organisms","Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes"]
["YML094W","GIM5",6323544,25,15,0,0,"Prefoldin","NA","cellular organisms","Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it"]
["YML100W","TSL1",6323537,25,5,0,0,"Glyco_transf_20~Trehalose_PPase","NA","cellular organisms","Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function"]
["YMR135C","GID8",6323784,25,9,0,0,"RanBPM_CRA","NA","Ascomycota","Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START"]
["YMR299C","DYN3",6323957,25,14,0,0,"NA","NA","Saccharomycetaceae","Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration"]
["YNL265C","IST1",6324064,25,9,0,0,"DUF292","NA","Eukaryota","Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p"]
["YNL333W","SNZ2",6323996,25,6,0,0,"SOR_SNZ","NA","cellular organisms","Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p"]
["YOL017W","ESC8",6324556,25,8,0,0,"NA","NA","Saccharomycetaceae","Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex"]
["YOL055C","THI20",6324517,25,6,0,0,"Phos_pyr_kin~TENA_THI-4","NA","cellular organisms","Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p"]
["YOR035C","SHE4",6324609,25,30,0,0,"NA","NA","Fungi/Metazoa group","Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization"]
["YOR189W","IES4",6324763,25,13,0,0,"NA","NA","Saccharomycetaceae","Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses"]
["YOR370C","MRS6",6324946,25,10,0,0,"GDI~GDI","NA","Eukaryota","Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)"]
["YPL227C","ALG5",6325029,25,21,0,0,"Glycos_transf_2","2.4.1.117_Dolichyl-phosphate beta-glucosyltransferase","cellular organisms","UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum"]
["YPR071W","YPR071W",6325328,25,6,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YAL008W","FUN14",6319311,25,9,0,1,"FUN14","NA","Saccharomycetales","Mitochondrial protein of unknown function"]
["YBR262C","AIM5",6319740,25,10,1,1,"NA","NA","Saccharomycetaceae","Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media"]
["YER080W","AIM9",6320924,25,10,1,1,"NA","NA","Dikarya","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YNL239W","LAP3",27808714,25,14,0,1,"Peptidase_C1_2","3.4.22.40_Bleomycin hydrolase","cellular organisms","Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH"]
["YPR140W","TAZ1",6325398,25,8,0,1,"Acyltransferase","2.3.1.23_1-acylglycerophosphocholine O-acyltransferase","Eukaryota","Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome"]
["YAL022C","FUN26",6319297,24,6,0,0,"Nucleoside_tran","NA","Eukaryota","Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes"]
["YBL054W","YBL054W",6319417,24,18,0,0,"Myb_DNA-binding","NA","Saccharomycetaceae","NA"]
["YBL061C","SKT5",6319410,24,15,0,0,"Sel1~Sel1~Sel1~Sel1~Sel1~Sel1","NA","cellular organisms","Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation"]
["YBR044C","TCM62",6319518,24,19,0,0,"NA","NA","cellular organisms","Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone"]
["YBR161W","CSH1",6319637,24,5,0,0,"Gly_transf_sug","NA","cellular organisms","Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p"]
["YBR205W","KTR3",6319682,24,12,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"]
["YCR015C","YCR015C",10383783,24,5,1,0,"NA","NA","Eukaryota","NA"]
["YDL180W","YDL180W",6320021,24,12,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR056C","YDR056C",6320261,24,3,1,0,"Pneumo_phosprot","NA","Saccharomycetaceae","NA"]
["YDR152W","GIR2",6320356,24,9,0,0,"RWD","NA","Eukaryota","Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)"]
["YDR484W","VPS52",6320692,24,24,0,0,"Vps52","NA","Eukaryota","Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin"]
["YFL017C","GNA1",14318503,24,4,0,0,"Acetyltransf_1","2.3.1.4_Glucosamine-phosphate N-acetyltransferase","cellular organisms","Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA"]
["YFR018C","YFR018C",14318540,24,5,1,0,"Peptidase_M28","NA","cellular organisms","NA"]
["YGL051W","MST27",6321387,24,5,0,0,"DUP","NA","Saccharomycetaceae","Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles"]
["YGL062W","PYC1",6321376,24,7,0,0,"CPSase_L_chain~ATP-grasp~CPSase_L_D2~Biotin_carb_C~HMGL-like~HMGL-like~PYC_OADA~Biotin_lipoyl","6.4.1.1_Pyruvate carboxylase","cellular organisms","Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"]
["YGL094C","PAN2",6321344,24,11,0,0,"Exonuc_X-T","3.1.13.4_Poly(A)-specific ribonuclease","Eukaryota","Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes"]
["YGL169W","SUA5",6321269,24,4,0,0,"Sua5_yciO_yrdC~SUA5","NA","cellular organisms","Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start"]
["YGL261C","PAU11",6321176,24,10,1,0,"SRP1_TIP1","NA","Saccharomycetaceae","Putative protein of unknown function; mRNA expression appears to be regulated by SUT1 and UPC2"]
["YGR077C","PEX8",6321514,24,14,0,0,"NA","NA","Saccharomycetaceae","Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p"]
["YGR206W","MVB12",6321645,24,17,0,0,"Mvb12","NA","Saccharomycetaceae","ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome"]
["YHR036W","BRL1",6321825,24,8,0,0,"Brr6_like_C_C","NA","Eukaryota","Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export"]
["YHR129C","ARP1",6321921,24,45,0,0,"Actin","NA","cellular organisms","Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin"]
["YHR136C","SPL2",6321928,24,12,0,0,"NA","NA","Saccharomyces cerevisiae","Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YJL193W","YJL193W",6322268,24,28,1,0,"TPT","NA","Eukaryota","NA"]
["YJR043C","POL32",6322503,24,17,0,0,"NA","NA","Saccharomycetaceae","Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p"]
["YJR108W","ABM1",6322568,24,11,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function, required for normal microtubule organization"]
["YKL092C","BUD2",6322758,24,10,0,0,"C2~RasGAP","NA","Fungi/Metazoa group","GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types"]
["YLR048W","RPS0B",6323077,24,6,0,0,"Ribosomal_S2","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"]
["YLR107W","REX3",6323136,24,6,0,0,"Exonuc_X-T","NA","Eukaryota","RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases"]
["YMR004W","MVP1",6323646,24,15,0,0,"PX","NA","Eukaryota","Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole"]
["YMR160W","YMR160W",6323812,24,15,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR164C","MSS11",6323816,24,9,0,0,"LisH","NA","Saccharomyces cerevisiae","Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals"]
["YMR172W","HOT1",6323824,24,4,0,0,"NA","NA","Saccharomycetaceae","Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p"]
["YNL080C","EOS1",6324249,24,14,0,0,"NA","NA","Ascomycota","Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene"]
["YNL217W","YNL217W",6324112,24,5,1,0,"Metallophos","NA","cellular organisms","NA"]
["YNR030W","ALG12",6324357,24,12,0,0,"Glyco_transf_22","NA","Eukaryota","Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation"]
["YOR018W","ROD1",6324592,24,10,0,0,"Arrestin_N~Arrestin_C","NA","Ascomycota","Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains 2 PY motifs, which are required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase"]
["YOR163W","DDP1",6324737,24,16,0,0,"NUDIX","3.6.1.52_Diphosphoinositol-polyphosphate diphosphatase","cellular organisms","Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases"]
["YOR253W","NAT5",6324827,24,6,0,0,"Acetyltransf_1","NA","Eukaryota","Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"]
["YOR307C","SLY41",6324883,24,8,0,0,"TPT","NA","Eukaryota","Protein involved in ER-to-Golgi transport"]
["YPL066W","YPL066W",6325191,24,23,1,0,"NA","NA","Saccharomycetales","NA"]
["YPL272C","YPL272C",6324983,24,11,1,0,"AATase","NA","Saccharomycetaceae","NA"]
["YPR046W","MCM16",6325303,24,11,0,0,"NA","NA","Saccharomycetaceae","Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA"]
["YBR176W","ECM31",6319653,24,4,0,1,"Pantoate_transf","2.1.2.11_3-methyl-2-oxobutanoate hydroxymethyltransferase","cellular organisms","Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate"]
["YBR227C","MCX1",6319704,24,10,0,1,"DEAD~AAA_2~Sigma54_activat~IstB~AAA~AAA_5~Mg_chelatase~AAA_2~ClpB_D2-small","NA","cellular organisms","Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins"]
["YDR332W","IRC3",6320539,24,9,0,1,"ResIII~DEAD~Helicase_C","NA","cellular organisms","Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion"]
["YFL018C","LPD1",14318501,24,14,0,1,"HI0933_like~FAD_binding_2~GIDA~Pyr_redox_2~Pyr_redox~Pyr_redox_dim","1.8.1.4_Dihydrolipoyl dehydrogenase","cellular organisms","Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes"]
["YMR189W","GCV2",6323843,24,7,0,1,"GDC-P","1.4.4.2_Glycine dehydrogenase (decarboxylating)","cellular organisms","P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm"]
["YNR001C","CIT1",6324328,24,15,0,1,"Citrate_synt","NA","cellular organisms","Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein"]
["YAR002C-A","ERP1",6319319,23,6,0,0,"EMP24_GP25L","NA","Eukaryota","Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles"]
["YBL017C","PEP1",6319454,23,9,0,0,"CHB_HEX_C","NA","Eukaryota","Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments"]
["YBR005W","RCR1",6319477,23,7,0,0,"DUF1183","NA","Ascomycota","Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane"]
["YBR078W","ECM33",6319552,23,16,0,0,"Recep_L_domain","NA","cellular organisms","GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p"]
["YCL049C","YCL049C",10383758,23,4,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDL073W","YDL073W",6320130,23,15,1,0,"DUF1765","NA","Saccharomycetaceae","NA"]
["YDL153C","SAS10",6320049,23,4,0,0,"Sas10_Utp3~Sas10_Utp3_C","NA","Eukaryota","Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing"]
["YDL156W","YDL156W",6320045,23,7,1,0,"WD40","NA","cellular organisms","NA"]
["YDR003W","RCR2",6320206,23,4,0,0,"FtsH_ext","NA","Ascomycota","Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p"]
["YDR076W","RAD55",6320281,23,20,0,0,"NA","NA","cellular organisms","Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p"]
["YDR120C","TRM1",6320325,23,32,0,0,"TRM~Met_10","2.1.1.32_tRNA (guanine-N(2)-)-methyltransferase","cellular organisms","tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments"]
["YDR170C","SEC7",6320374,23,4,0,0,"Sec7~DUF1981","NA","Eukaryota","Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles"]
["YDR369C","XRS2",6320577,23,17,0,0,"FHA","NA","Saccharomycetaceae","Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling"]
["YDR501W","PLM2",6320709,23,8,0,0,"FHA","NA","Ascomycota","Protein required for partitioning of the 2-micron plasmid"]
["YER044C-A","MEI4",6320884,23,13,0,0,"NA","NA","Saccharomycetaceae","Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores"]
["YER093C-A","AIM11",6320940,23,17,1,0,"NA","NA","Saccharomycetales","Putative protein of unknown function; YER093C-A contains an intron; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YER104W","RTT105",6320951,23,3,0,0,"NA","NA","Saccharomycetaceae","Protein with a role in regulation of Ty1 transposition"]
["YFL031W","HAC1",14318488,23,18,0,0,"bZIP_2~bZIP_1","NA","Ascomycota","bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis"]
["YFR012W","YFR012W",14318534,23,4,1,0,"PalI","NA","Saccharomyces cerevisiae","NA"]
["YGL032C","AGA2",6321406,23,4,0,0,"NA","NA","Saccharomycetaceae","Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds"]
["YGL035C","MIG1",6321403,23,25,0,0,"zf-C2H2","NA","Fungi/Metazoa group","Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase"]
["YGL254W","FZF1",6321183,23,9,0,0,"zf-C2H2~zf-C2H2~zf-C2H2","NA","Eukaryota","Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers"]
["YGR044C","RME1",6321481,23,3,0,0,"zf-C2H2","NA","Ascomycota","Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation"]
["YHL009C","YAP3",6321778,23,32,0,0,"bZIP_1","NA","Ascomycota","Basic leucine zipper (bZIP) transcription factor"]
["YHR066W","SSF1",6321857,23,8,0,0,"Brix","NA","Eukaryota","Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family"]
["YHR087W","YHR087W",6321879,23,11,0,0,"SBDS","NA","Dikarya","Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity"]
["YJL084C","ALY2",6322377,23,7,0,0,"Arrestin_N","NA","Dikarya","Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase"]
["YJL126W","NIT2",6322335,23,6,0,0,"CN_hydrolase","NA","cellular organisms","Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member"]
["YJR044C","VPS55",6322504,23,4,0,0,"Vps55","NA","Eukaryota","Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)"]
["YJR135C","MCM22",6322595,23,6,0,0,"NA","NA","Saccharomycetaceae","Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner"]
["YKL146W","AVT3",6322702,23,5,0,0,"Aa_trans","NA","Eukaryota","Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"]
["YKL185W","ASH1",6322663,23,14,0,0,"GATA","NA","Saccharomycetaceae","Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate"]
["YKL206C","ADD66",6322643,23,11,0,0,"HCCA3","NA","Eukaryota","Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly"]
["YKR045C","YKR045C",37362675,23,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKR056W","TRM2",42759862,23,15,0,0,"TRAM~tRNA_U5-meth_tr~MTS~Methyltransf_11~tRNA_U5-meth_tr","2.1.1.35_tRNA (uracil-5-)-methyltransferase","cellular organisms","tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair"]
["YLR019W","PSR2",6323047,23,12,0,0,"NIF","NA","cellular organisms","Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p"]
["YLR071C","RGR1",6323100,23,4,0,0,"MED14","NA","Dikarya","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation"]
["YLR262C","YPT6",6323291,23,17,0,0,"Miro~Ras","NA","cellular organisms","GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6"]
["YLR308W","CDA2",6323339,23,18,0,0,"Polysacc_deac_1","3.5.1.41_Chitin deacetylase","cellular organisms","Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall"]
["YMR010W","YMR010W",6323652,23,22,1,0,"NA","NA","Eukaryota","NA"]
["YMR039C","SUB1",6323682,23,20,0,0,"PC4","NA","Fungi/Metazoa group","Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations"]
["YNL078W","NIS1",6324251,23,10,0,0,"NA","NA","Saccharomycetaceae","Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network"]
["YNL133C","FYV6",6324196,23,14,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining"]
["YNL233W","BNI4",6324096,23,18,0,0,"NA","NA","Saccharomycetaceae","Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p"]
["YNL280C","ERG24",6324049,23,34,0,0,"ERG4_ERG24~MgtE","NA","cellular organisms","C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions"]
["YOR010C","TIR2",6324584,23,6,0,0,"SRP1_TIP1~PIR","NA","Saccharomycetaceae","Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis"]
["YOR160W","MTR10",6324734,23,9,0,0,"IBN_N~Xpo1","NA","Eukaryota","Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p"]
["YOR179C","SYC1",6324753,23,12,0,0,"NA","NA","Saccharomycetaceae","Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs"]
["YPL022W","RAD1",6325235,23,14,0,0,"ERCC4","NA","Eukaryota","Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein"]
["YPL053C","KTR6",6325204,23,13,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family"]
["YPL121C","MEI5",6325136,23,11,0,0,"Mei5","NA","Saccharomycetales","Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p"]
["YPL150W","YPL150W",6325107,23,13,1,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","NA"]
["YPL171C","OYE3",6325086,23,8,0,0,"Oxidored_FMN","1.6.99.1_NADPH dehydrogenase","cellular organisms","Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism"]
["YPL240C","HSP82",6325016,23,15,0,0,"HATPase_c~HSP90","NA","cellular organisms","Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p"]
["YPR045C","MNI2",6325302,23,7,1,0,"SAC3_GANP","NA","Eukaryota","Deletion mutant is synthetically lethal with MEN mutants"]
["YPR131C","NAT3",31126970,23,12,0,0,"Acetyltransf_1","2.3.1.88_Peptide alpha-N-acetyltransferase","cellular organisms","Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met"]
["YDL142C","CRD1",6320059,23,13,0,1,"CDP-OH_P_transf","NA","cellular organisms","Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function"]
["YHR067W","HTD2",6321858,23,7,0,1,"NA","NA","cellular organisms","Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology"]
["YLR395C","COX8",6323427,23,7,0,1,"COX7C","1.9.3.1_Cytochrome-c oxidase","Saccharomycetales","Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"]
["YMR225C","MRPL44",6323881,23,5,0,1,"MRP_L53","NA","Ascomycota","Mitochondrial ribosomal protein of the large subunit"]
["YOR187W","TUF1",6324761,23,6,0,1,"GTP_EFTU~GTP_EFTU_D2~GTP_EFTU_D3","NA","cellular organisms","Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans"]
["YBL079W","NUP170",6319392,22,18,0,0,"Nucleoporin","NA","Eukaryota","Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p"]
["YBR023C","CHS3",6319497,22,20,0,0,"Chitin_synth_2","2.4.1.16_Chitin synthase","Eukaryota","Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan"]
["YBR041W","FAT1",41629676,22,15,0,0,"AMP-binding","NA","cellular organisms","Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids"]
["YBR094W","PBY1",6319570,22,11,0,0,"SurE~TTL","NA","cellular organisms","Putative tubulin tyrosine ligase associated with P-bodies"]
["YBR208C","DUR1,2",6319685,22,21,0,0,"Amidase~CPSase_L_chain~CPSase_L_D2~ATP-grasp~Biotin_carb_C~AHS2~AHS1~Biotin_lipoyl","3.5.1.54_Allophanate hydrolase|6.3.4.6_Urea carboxylase","cellular organisms","Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"]
["YCL008C","STP22",42759852,22,51,0,0,"UEV~Vps23_core","NA","Eukaryota","Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype"]
["YDL126C","CDC48",6320077,22,7,0,0,"CDC48_N~CDC48_2~AAA~AAA_3~AAA_5~Mg_chelatase~IstB~AAA~AAA_3~AAA_5~Parvo_NS1~AAA_2~Mg_chelatase","NA","cellular organisms","ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome"]
["YDL160C","DHH1",6320041,22,25,0,0,"DEAD~Helicase_C","NA","cellular organisms","Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation"]
["YDL161W","ENT1",6320039,22,10,0,0,"ENTH","NA","Eukaryota","Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus"]
["YDL222C","FMP45",6319979,22,6,0,0,"SUR7","NA","Ascomycota","Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C"]
["YDR221W","GTB1",6320427,22,8,0,0,"NA","NA","Eukaryota","Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER"]
["YDR265W","PEX10",6320471,22,13,0,0,"Pex2_Pex12~zf-C3HC4","NA","Eukaryota","C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders"]
["YDR328C","SKP1",6320535,22,3,0,0,"Skp1_POZ~Cenp-B_dimeris~Skp1_POZ~Skp1","NA","Eukaryota","Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase"]
["YDR380W","ARO10",6320588,22,5,0,0,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","NA","cellular organisms","Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway"]
["YDR386W","MUS81",6320594,22,24,0,0,"ERCC4","NA","Eukaryota","Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p"]
["YDR440W","DOT1",6320648,22,7,0,0,"DOT1","2.1.1.43_Histone-lysine N-methyltransferase","Eukaryota","Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization"]
["YDR506C","YDR506C",6320714,22,6,1,0,"Cu-oxidase_3~Cu-oxidase_3~Cu-oxidase~Cu-oxidase_2","NA","cellular organisms","NA"]
["YEL026W","SNU13",6320809,22,7,0,0,"Ribosomal_L7Ae","NA","cellular organisms","RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein"]
["YGL117W","YGL117W",6321321,22,12,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGR146C","YGR146C",6321585,22,14,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGR227W","DIE2",6321666,22,18,0,0,"DIE2_ALG10","NA","Eukaryota","Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1"]
["YGR260W","TNA1",6321698,22,9,0,0,"MFS_1","NA","cellular organisms","High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)"]
["YGR279C","SCW4",6321718,22,4,0,0,"Glyco_hydro_17","NA","cellular organisms","Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating"]
["YHR017W","YSC83",6321805,22,13,0,0,"DUF1776","NA","Saccharomycetaceae","Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83"]
["YHR183W","GND1",6321977,22,10,0,0,"NAD_binding_2~6PGD","NA","cellular organisms","6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress"]
["YIL045W","PIG2",6322144,22,17,0,0,"CBM_21","NA","Fungi/Metazoa group","Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase"]
["YIL162W","SUC2",6322029,22,7,0,0,"Glyco_hydro_32N~Glyco_hydro_32C","3.2.1.26_Beta-fructofuranosidase","cellular organisms","Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively"]
["YJL170C","ASG7",85666117,22,5,0,0,"NA","NA","Saccharomycetaceae","Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor"]
["YJL192C","SOP4",6322269,22,35,0,0,"NA","NA","Saccharomycetaceae","ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER"]
["YKL041W","VPS24",6322810,22,30,0,0,"Snf7","NA","Eukaryota","One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway"]
["YKL198C","PTK1",27808711,22,9,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein"]
["YKR035W-A","DID2",6322887,22,17,0,0,"Snf7","NA","Eukaryota","Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors"]
["YKR044W","UIP5",6322897,22,6,0,0,"Lectin_legB","NA","Fungi/Metazoa group","Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates"]
["YKR091W","SRL3",50593426,22,5,0,0,"NA","NA","Saccharomycetaceae","Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate"]
["YLR074C","BUD20",6323103,22,20,0,0,"NA","NA","Eukaryota","Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YLR179C","YLR179C",6323208,22,3,1,0,"PBP","NA","Eukaryota","NA"]
["YLR189C","ATG26",6323218,22,3,0,0,"PH~GRAM~Glyco_transf_28~UDPGT","NA","cellular organisms","UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy"]
["YLR285W","NNT1",6323315,22,10,0,0,"Methyltransf_16","2.1.1.1_Nicotinamide N-methyltransferase","cellular organisms","Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination"]
["YML008C","ERG6",6323635,22,14,0,0,"Methyltransf_15~CMAS~Methyltransf_11~Methyltransf_12~Sterol_MT_C","2.1.1.41_Sterol 24-C-methyltransferase","cellular organisms","Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane"]
["YML127W","RSC9",6323508,22,6,0,0,"NA","NA","Dikarya","Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway"]
["YMR195W","ICY1",6323851,22,13,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation"]
["YNL065W","AQR1",6324264,22,14,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids"]
["YNL292W","PUS4",6324037,22,10,0,0,"TruB_N","NA","cellular organisms","Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)"]
["YNR007C","ATG3",6324334,22,21,0,0,"Autophagy_N~Autophagy_act_C~Autophagy_Cterm","NA","Eukaryota","E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt"]
["YOL078W","AVO1",6324494,22,11,0,0,"SIN1","NA","Dikarya","Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth"]
["YOL084W","PHM7",6324488,22,9,0,0,"DUF221","NA","Eukaryota","Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole"]
["YOL108C","INO4",6324464,22,15,0,0,"NA","NA","Ascomycota","Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain"]
["YOL124C","TRM11",6324448,22,11,0,0,"UPF0020","NA","cellular organisms","Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain"]
["YOR008C","SLG1",6324581,22,9,0,0,"WSC","NA","Ascomycota","Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response"]
["YOR043W","WHI2",6324617,22,50,0,0,"NA","NA","Dikarya","Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression"]
["YOR219C","STE13",6324793,22,5,0,0,"DPPIV_N~Peptidase_S9","NA","cellular organisms","Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor"]
["YPL049C","DIG1",6325208,22,13,0,0,"NA","NA","Saccharomycetaceae","Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription"]
["YPL125W","KAP120",6325132,22,12,0,0,"IBN_N","NA","Eukaryota","Karyopherin with a role in the assembly or export of 60S ribosomal subunits"]
["YPL221W","FLC1",6325035,22,5,0,0,"TRP","NA","Dikarya","Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance"]
["YBL098W","BNA4",6319372,22,12,0,1,"DAO~Pyr_redox~GIDA~FAD_binding_3","1.14.13.9_Kynurenine 3-monooxygenase","cellular organisms","Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease"]
["YDL120W","YFH1",6320083,22,6,0,1,"Frataxin_Cyay~Aminotran_3","NA","cellular organisms","Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia"]
["YDR258C","HSP78",6320464,22,8,0,1,"AAA~AAA_2~AAA_5~AAA_5~ClpB_D2-small","NA","cellular organisms","Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system"]
["YGR031W","YGR031W",6321468,22,7,1,1,"PGAP1~Abhydrolase_1~Esterase","NA","cellular organisms","NA"]
["YGR049W","SCM4",6321486,22,4,0,1,"NA","NA","Saccharomycetaceae","Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis"]
["YKL027W","YKL027W",6322825,22,15,0,1,"Shikimate_DH~ThiF","NA","cellular organisms","NA"]
["YKL040C","NFU1",6322811,22,11,0,1,"Nfu_N~NifU","NA","cellular organisms","Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria"]
["YLR356W","YLR356W",6323388,22,9,1,1,"NA","NA","Ascomycota","NA"]
["YML120C","NDI1",6323515,22,9,0,1,"Pyr_redox_2~Pyr_redox","1.6.5.3_NADH dehydrogenase (ubiquinone)","cellular organisms","NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID"]
["YMR188C","MRPS17",6323842,22,10,0,1,"Ribosomal_S17","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YNL121C","TOM70",6324208,22,13,0,1,"TPR_1~TPR_2~TPR_1~TPR_2","NA","cellular organisms","Component (70 kDa) of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins"]
["YPR067W","ISA2",6325324,22,12,0,1,"Fe-S_biosyn~Fe-S_biosyn","NA","cellular organisms","Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations"]
["YAL060W","BDH1",6319258,21,9,0,0,"ADH_N~ADH_zinc_N","1.1.1.4_(R,R)-butanediol dehydrogenase","cellular organisms","NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source"]
["YBR258C","SHG1",6319735,21,5,0,0,"Cps15","NA","Saccharomycetaceae","Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres"]
["YBR298C","MAL31",6319775,21,23,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C"]
["YCL001W","RER1",6319844,21,17,0,0,"Rer1","NA","Eukaryota","Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER"]
["YCL001W-A","YCL001W-A",6319845,21,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YCR011C","ADP1",10383780,21,6,0,0,"Laminin_EGF~DUF258~ATP-synt_ab~ABC_tran~ABC2_membrane","NA","Saccharomyces cerevisiae","Putative ATP-dependent permease of the ABC transporter family of proteins"]
["YCR030C","SYP1",10383792,21,8,0,0,"SAFF","NA","Dikarya","Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation"]
["YCR088W","ABP1",6319931,21,17,0,0,"Cofilin_ADF~SH3_1~SH3_2","NA","Fungi/Metazoa group","Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization"]
["YDR252W","BTT1",6320458,21,9,0,0,"NAC","NA","Eukaryota","Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3"]
["YDR319C","YFT2",6320525,21,13,1,0,"Scs3p","NA","Fungi/Metazoa group","Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens"]
["YDR387C","YDR387C",6320595,21,5,1,0,"Sugar_tr~MFS_1~Sugar_tr~MFS_1","NA","cellular organisms","NA"]
["YDR391C","YDR391C",6320599,21,9,1,0,"NA","NA","Ascomycota","NA"]
["YDR475C","JIP4",37362637,21,20,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence"]
["YER067W","YER067W",6320910,21,7,1,0,"NA","NA","Saccharomycetales","NA"]
["YFL033C","RIM15",14318486,21,13,0,0,"Pkinase~Pkinase~Response_reg","NA","Dikarya","Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase"]
["YFR001W","LOC1",14318523,21,7,0,0,"NA","NA","Ascomycota","Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles"]
["YGR094W","VAS1",6321531,21,5,0,0,"tRNA-synt_1~tRNA-synt_1g~Anticodon_1","6.1.1.9_Valine--tRNA ligase","cellular organisms","Mitochondrial and cytoplasmic valyl-tRNA synthetase"]
["YGR233C","PHO81",6321672,21,12,0,0,"SPX~Ank~Ank","NA","cellular organisms","Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p"]
["YHL020C","OPI1",6321767,21,26,0,0,"Opi1~Opi1~Opi1","NA","Ascomycota","Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance"]
["YHR021C","RPS27B",6321809,21,11,0,0,"Ribosomal_S27e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein"]
["YHR042W","NCP1",6321832,21,11,0,0,"Flavodoxin_1~FAD_binding_1~NAD_binding_1","1.6.2.4_NADPH--hemoprotein reductase","cellular organisms","NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p"]
["YHR065C","RRP3",37362659,21,5,0,0,"DEAD~Helicase_C","NA","cellular organisms","Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity"]
["YIL027C","KRE27",6322162,21,11,0,0,"Tmemb_32","NA","Ascomycota","Protein of unknown function; null mutant shows K1 killer toxin resistance"]
["YIL131C","FKH1",6322060,21,3,0,0,"FHA~Fork_head","NA","Fungi/Metazoa group","Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching"]
["YJL016W","YJL016W",37362668,21,5,1,0,"NA","NA","Saccharomycetales","NA"]
["YKL008C","LAC1",6322844,21,5,0,0,"TRAM1~TRAM_LAG1_CLN8","2.3.1.24_Sphingosine N-acyltransferase","Eukaryota","Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p"]
["YKL073W","LHS1",6322777,21,6,0,0,"HSP70~HSP70","3.6.1.3_Adenosinetriphosphatase","cellular organisms","Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway"]
["YKL109W","HAP4",6322740,21,23,0,0,"Hap4_Hap_bind","NA","Saccharomyces cerevisiae","Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex"]
["YLL053C","YLL053C",6322975,21,10,1,0,"MIP","NA","cellular organisms","NA"]
["YLR002C","NOC3",6323030,21,3,0,0,"NOC3p~CBF","NA","Eukaryota","Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation"]
["YLR043C","TRX1",6323072,21,5,0,0,"Redoxin~Thioredoxin~AhpC-TSA","NA","cellular organisms","Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance"]
["YLR093C","NYV1",9755337,21,4,0,0,"Nyv1_N~Synaptobrevin","NA","Eukaryota","v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane"]
["YLR299W","ECM38",6323330,21,13,0,0,"G_glu_transpept","NA","cellular organisms","Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation"]
["YLR376C","PSY3",6323408,21,21,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C"]
["YLR452C","SST2",6323485,21,6,0,0,"DEP~RGS~RGS","NA","Dikarya","GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family"]
["YML047C","PRM6",6323595,21,3,0,0,"NA","NA","Dikarya","Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating"]
["YML115C","VAN1",6323521,21,11,0,0,"Anp1","NA","Eukaryota","Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant"]
["YMR142C","RPL13B",6323791,21,9,0,0,"Ribosomal_L13e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein"]
["YMR209C","YMR209C",6323865,21,10,1,0,"N2227","NA","Eukaryota","NA"]
["YMR224C","MRE11",6323880,21,16,0,0,"Metallophos~Mre11_DNA_bind","NA","Eukaryota","Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved"]
["YNL021W","HDA1",6324307,21,6,0,0,"Hist_deacetyl~Arb2","3.5.1.98_Histone deacetylase","cellular organisms","Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation"]
["YNL096C","RPS7B",6324233,21,5,0,0,"Ribosomal_S7e","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins"]
["YNL195C","YNL195C",42742306,21,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YNL277W","MET2",6324052,21,2,0,0,"Abhydrolase_1","2.3.1.31_Homoserine O-acetyltransferase","cellular organisms","L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway"]
["YNL281W","HCH1",6324048,21,5,0,0,"Aha1_N","NA","Eukaryota","Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus"]
["YNL288W","CAF40",6324041,21,31,0,0,"Rcd1","NA","Eukaryota","Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p"]
["YNR066C","YNR066C",6324394,21,8,1,0,"NA","NA","Dikarya","NA"]
["YOL104C","NDJ1",6324468,21,8,0,0,"NA","NA","Saccharomycetaceae","Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes"]
["YOL155C","HPF1",6324418,21,10,0,0,"NA","NA","Saccharomycetaceae","Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines"]
["YOR023C","AHC1",6324597,21,23,0,0,"NA","NA","Saccharomycetaceae","Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex"]
["YOR078W","BUD21",6324652,21,7,0,0,"U3_snoRNA_assoc","NA","Saccharomycetales","Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern"]
["YOR173W","DCS2",116006500,21,8,0,0,"DcpS","NA","Eukaryota","Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p."]
["YOR241W","MET7",6324815,21,7,0,0,"NA","6.3.2.17_Tetrahydrofolate synthase","cellular organisms","Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA"]
["YPL194W","DDC1",6325062,21,20,0,0,"NA","NA","Saccharomycetales","DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate"]
["YPL213W","LEA1",6325043,21,12,0,0,"NA","NA","Eukaryota","Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein"]
["YPR173C","VPS4",6325431,21,37,0,0,"MIT~AAA_2~IstB~PPV_E1_C~Parvo_NS1~AAA~AAA_5~Mg_chelatase~Vps4_C","NA","cellular organisms","AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism"]
["YDR234W","LYS4",6320440,21,5,0,1,"Aconitase~Aconitase_C","4.2.1.36_Homoaconitate hydratase","cellular organisms","Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway"]
["YIL113W","SDP1",6322078,21,5,0,1,"DSPc","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock"]
["YMR286W","MRPL33",6323942,21,12,0,1,"Ribosomal_L30","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YNL211C","YNL211C",6324118,21,11,1,1,"NA","NA","Ascomycota","NA"]
["YOR196C","LIP5",6324770,21,8,0,1,"Radical_SAM","2.8.1.8_Lipoyl synthase","cellular organisms","Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase"]
["YBL078C","ATG8",6319393,20,9,0,0,"MAP1_LC3","NA","Eukaryota","Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation"]
["YBR125C","PTC4",6319601,20,12,0,0,"PP2C~PP2C","NA","cellular organisms","Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity"]
["YBR182C","SMP1",6319659,20,9,0,0,"SRF-TF","NA","Eukaryota","Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors"]
["YBR250W","SPO23",6319727,20,3,0,0,"Arrestin_N","NA","Saccharomycetaceae","Protein of unknown function; associates with meiosis-specific protein Spo1p"]
["YBR279W","PAF1",6319756,20,15,0,0,"Paf1","NA","Fungi/Metazoa group","RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1"]
["YCL016C","DCC1",10383774,20,15,0,0,"DUF2036","NA","Eukaryota","Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance"]
["YCL050C","APA1",10383757,20,6,0,0,"ATP_transf","2.7.7.5_Sulfate adenylyltransferase (ADP)|2.7.7.53_ATP adenylyltransferase","cellular organisms","Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p"]
["YCR048W","ARE1",6319896,20,12,0,0,"MBOAT","2.3.1.26_Sterol O-acyltransferase","Eukaryota","Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen"]
["YCR107W","AAD3",6319951,20,3,0,0,"Aldo_ket_red","NA","cellular organisms","Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"]
["YDL037C","BSC1",6320167,20,14,0,0,"Flo11","NA","Saccharomycetaceae","Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"]
["YDL046W","NPC2",6320157,20,5,0,0,"E1_DerP2_DerF2","NA","Eukaryota","Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes"]
["YDL059C","RAD59",6320144,20,25,0,0,"Rad52_Rad22","NA","Eukaryota","Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p"]
["YDR105C","TMS1",6320310,20,5,0,0,"Serinc","NA","Eukaryota","Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance"]
["YDR212W","TCP1",6320418,20,24,0,0,"Cpn60_TCP1","NA","cellular organisms","Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide"]
["YDR281C","PHM6",6320487,20,9,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function, expression is regulated by phosphate levels"]
["YDR320C","SWA2",6320526,20,16,0,0,"Ubiq-assoc","NA","Dikarya","Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles"]
["YDR470C","UGO1",7839165,20,5,0,0,"Mito_carr","NA","Dikarya","Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion"]
["YEL039C","CYC7",6320796,20,5,0,0,"Cytochrom_C","NA","cellular organisms","Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"]
["YEL051W","VMA8",6320784,20,23,0,0,"ATP-synt_D","NA","cellular organisms","Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis"]
["YEL067C","YEL067C",6320769,20,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YER062C","HOR2",6320905,20,10,0,0,"Hydrolase","NA","cellular organisms","One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition"]
["YER119C","AVT6",6320965,20,6,0,0,"Aa_trans","NA","Eukaryota","Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"]
["YGR232W","NAS6",6321671,20,2,0,0,"Ank~Ank~Ank","NA","cellular organisms","Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6"]
["YHL024W","RIM4",6321763,20,9,0,0,"RRM_1~RRM_1","NA","Eukaryota","Putative RNA-binding protein required for the expression of early and middle sporulation genes"]
["YHR124W","NDT80",6321916,20,14,0,0,"NDT80_PhoG","NA","Ascomycota","Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)"]
["YIL006W","YIA6",6322185,20,27,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs"]
["YIL074C","SER33",6322116,20,4,0,0,"2-Hacid_dh~2-Hacid_dh_C","NA","cellular organisms","3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p"]
["YIL099W","SGA1",6322092,20,11,0,0,"Glyco_hydro_15","3.2.1.3_Glucan 1,4-alpha-glucosidase","cellular organisms","Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation"]
["YJL013C","MAD3",6322447,20,9,0,0,"Mad3_BUB1_I~Mad3_BUB1_II","NA","Eukaryota","Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover"]
["YJL024C","APS3",6322436,20,29,0,0,"Clat_adaptor_s","NA","Eukaryota","Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function"]
["YJL029C","VPS53",6322431,20,19,0,0,"Vps53_N","NA","Eukaryota","Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting"]
["YJL111W","CCT7",6322350,20,21,0,0,"Cpn60_TCP1","NA","cellular organisms","Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"]
["YJL163C","YJL163C",6322298,20,6,1,0,"MFS_1~MFS_1","NA","Fungi/Metazoa group","NA"]
["YJR067C","YAE1",6322527,20,2,0,0,"Yae1_N~DUF1715","NA","Eukaryota","Essential protein of unknown function"]
["YJR103W","URA8",6322563,20,13,0,0,"CTP_synth_N~GATase","6.3.4.2_CTP synthase","cellular organisms","Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis"]
["YJR118C","ILM1",6322578,20,18,0,0,"Ilm1","NA","Ascomycota","Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth"]
["YKL080W","VMA5",6322770,20,18,0,0,"V-ATPase_C","NA","Eukaryota","Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"]
["YLR116W","MSL5",6323145,20,2,0,0,"KH_1~zf-CCHC","NA","Eukaryota","Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA"]
["YLR127C","APC2",6323156,20,5,0,0,"Cullin~APC2","NA","Eukaryota","Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p"]
["YLR147C","SMD3",6323176,20,4,0,0,"LSM","NA","cellular organisms","Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3"]
["YML032C","RAD52",27808713,20,16,0,0,"Rad52_Rad22","NA","Eukaryota","Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis"]
["YML100W-A","YML100W-A",33438850,20,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YML117W","NAB6",6323518,20,39,0,0,"RRM~Nab6_mRNP_bdg","NA","Saccharomycetaceae","Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data"]
["YOL110W","SHR5",6324462,20,17,0,0,"Erf4","NA","Saccharomycetales","Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization"]
["YOR087W","YVC1",27808717,20,7,0,0,"NA","NA","Fungi/Metazoa group","Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock"]
["YOR284W","HUA2",6324858,20,5,0,0,"NA","NA","Saccharomyces cerevisiae","Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly"]
["YOR308C","SNU66",6324884,20,10,0,0,"SART-1~SART-1~SART-1","NA","Eukaryota","Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures"]
["YPL011C","TAF3",6325246,20,3,0,0,"Bromo_TP","NA","Ascomycota","TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation"]
["YPL014W","YPL014W",6325243,20,11,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL111W","CAR1",6325146,20,11,0,0,"Arginase","3.5.3.1_Arginase","cellular organisms","Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance"]
["YPL176C","TRE1",6325081,20,30,0,0,"PA~TFR_dimer","NA","cellular organisms","Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors"]
["YPL200W","CSM4",6325056,20,14,0,0,"NA","NA","Saccharomyces cerevisiae","Protein required for accurate chromosome segregation during meiosis"]
["YPL212C","PUS1",6325044,20,15,0,0,"PseudoU_synth_1~PseudoU_synth_1","NA","cellular organisms","tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA"]
["YPL265W","DIP5",6324990,20,14,0,0,"AA_permease","NA","cellular organisms","Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly"]
["YPR052C","NHP6A",6325309,20,12,0,0,"HMG_box","NA","Eukaryota","High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters"]
["YBR269C","FMP21",41629680,20,14,1,1,"DUF1674","NA","Dikarya","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YBR291C","CTP1",6319768,20,27,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family"]
["YEL052W","AFG1",6320783,20,19,0,1,"AFG1_ATPase~AFG1_ATPase~AFG1_ATPase","NA","cellular organisms","Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain"]
["YHL032C","GUT1",6321755,20,9,0,1,"FGGY_N~FGGY_N~FGGY_C~FGGY_C~FGGY_C","2.7.1.30_Glycerol kinase","cellular organisms","Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p"]
["YHR189W","PTH1",6321983,20,16,0,1,"Pept_tRNA_hydro","3.1.1.29_Aminoacyl-tRNA hydrolase","cellular organisms","One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration"]
["YLR283W","YLR283W",6323312,20,8,1,1,"NA","NA","Ascomycota","NA"]
["YLR439W","MRPL4",6323472,20,7,0,1,"MRP-L47","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit"]
["YNL071W","LAT1",6324258,20,6,0,1,"Biotin_lipoyl~E3_binding~2-oxoacid_dh","2.3.1.12_Dihydrolipoyllysine-residue acetyltransferase","cellular organisms","Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA"]
["YAL046C","AIM1",6319270,19,7,1,0,"BolA","NA","cellular organisms","Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YAL062W","GDH3",6319256,19,10,0,0,"ELFV_dehydrog_N~ELFV_dehydrog","1.4.1.4_Glutamate dehydrogenase (NADP(+))","cellular organisms","NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources"]
["YBL002W","HTB2",6319471,19,11,0,0,"Histone","NA","Eukaryota","One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation"]
["YBR016W","YBR016W",6319490,19,2,1,0,"NA","NA","cellular organisms","NA"]
["YBR073W","RDH54",37362617,19,9,0,0,"SNF2_N~ResIII~Helicase_C","NA","cellular organisms","DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference"]
["YBR106W","PHO88",6319582,19,25,0,0,"Pho88","NA","Eukaryota","Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations"]
["YBR295W","PCA1",6319772,19,17,0,0,"E1-E2_ATPase~Hydrolase","3.6.3.4_Copper-exporting ATPase","cellular organisms","Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function"]
["YCL056C","YCL056C",6319794,19,7,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YCR068W","ATG15",10383802,19,24,0,0,"Lipase_3","NA","Fungi","Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway"]
["YDL049C","KNH1",6320154,19,3,0,0,"KRE9","NA","Ascomycota","Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant"]
["YDL134C","PPH21",6320067,19,17,0,0,"Metallophos","NA","cellular organisms","Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis"]
["YDL176W","YDL176W",6320025,19,9,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR126W","SWF1",6320331,19,17,0,0,"zf-DHHC","NA","Eukaryota","Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion"]
["YDR168W","CDC37",6320372,19,7,0,0,"CDC37_N~CDC37_M~CDC37_C","NA","Fungi/Metazoa group","Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding"]
["YDR253C","MET32",6320459,19,22,0,0,"zf-C2H2~zf-C2H2","NA","Eukaryota","Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p"]
["YDR262W","YDR262W",6320468,19,9,1,0,"NA","NA","Ascomycota","NA"]
["YDR309C","GIC2",6320515,19,15,0,0,"PBD","NA","Saccharomycetaceae","Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region"]
["YDR415C","YDR415C",6320623,19,9,1,0,"Peptidase_M28~Peptidase_M20","NA","cellular organisms","NA"]
["YDR459C","PFA5",6320667,19,11,0,0,"zf-DHHC","NA","Eukaryota","Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain"]
["YER036C","ARB1",6320874,19,10,0,0,"ABC_tran~Miro~VirE~ABC_tran","NA","cellular organisms","ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p"]
["YER063W","THO1",6320906,19,9,0,0,"SAP","NA","Dikarya","Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation"]
["YER098W","UBP9",6320945,19,7,0,0,"UCH","3.1.2.15_Ubiquitin thiolesterase","Eukaryota","Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions"]
["YFL023W","BUD27",22532997,19,10,0,0,"Prefoldin~UK","NA","Saccharomycetales","Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition"]
["YGL096W","TOS8",6321342,19,6,0,0,"Coprinus_mating~Homeobox","NA","Eukaryota","Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p"]
["YGL121C","GPG1",6321317,19,3,0,0,"NA","NA","Saccharomycetaceae","Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p"]
["YGL136C","MRM2",6321302,19,8,0,0,"FtsJ~FtsJ","NA","cellular organisms","Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ"]
["YGL224C","SDT1",6321214,19,10,0,0,"Hydrolase","NA","cellular organisms","Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives"]
["YGR029W","ERV1",6681846,19,11,0,0,"Evr1_Alr","1.8.3.2_Thiol oxidase","Eukaryota","Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)"]
["YGR054W","YGR054W",6321491,19,16,0,0,"eIF2A","NA","Eukaryota","NA"]
["YHR047C","AAP1",6321837,19,3,0,0,"Peptidase_M1","NA","cellular organisms","Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation"]
["YHR133C","NSG1",6321925,19,16,0,0,"NA","NA","Ascomycota","Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins"]
["YHR135C","YCK1",6321927,19,20,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p"]
["YHR191C","CTF8",6321985,19,15,0,0,"Ctf8","NA","Eukaryota","Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion"]
["YIL036W","CST6",6322153,19,7,0,0,"bZIP_1~bZIP_2","NA","Saccharomycetales","Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance"]
["YIL063C","YRB2",6322126,19,6,0,0,"Ran_BP1","NA","Eukaryota","Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential"]
["YJL027C","YJL027C",6322433,19,11,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YJL121C","RPE1",6322341,19,9,0,0,"Ribul_P_3_epim~OMPdecase","5.1.3.1_Ribulose-phosphate 3-epimerase","cellular organisms","D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress"]
["YJL203W","PRP21",6322258,19,13,0,0,"Surp~Surp","NA","Eukaryota","Subunit of the SF3a splicing factor complex, required for spliceosome assembly"]
["YJR112W","NNF1",6322572,19,3,0,0,"Nnf1","NA","Ascomycota","Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation"]
["YKL010C","UFD4",6322842,19,7,0,0,"HECT","NA","Eukaryota","Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins"]
["YKL047W","YKL047W",6322804,19,5,1,0,"DUF2347","NA","Fungi/Metazoa group","NA"]
["YKL053C-A","MDM35",6322797,19,10,0,0,"UPF0203","NA","Eukaryota","Mitochondrial intermembrane space cysteine motif protein; mutation affects mitochondrial distribution and morphology"]
["YKL217W","JEN1",6322632,19,7,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose"]
["YKR061W","KTR2",6322914,19,4,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"]
["YKR100C","SKG1",42759863,19,8,0,0,"SKG6","NA","Saccharomycetaceae","Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell"]
["YLL013C","PUF3",6323016,19,10,0,0,"PUF~PUF~PUF~PUF~PUF~PUF~PUF~PUF","NA","Eukaryota","Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins"]
["YLL018C","DPS1",6323011,19,4,0,0,"tRNA_anti~tRNA-synt_2","6.1.1.12_Aspartate--tRNA ligase","cellular organisms","Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation"]
["YLR056W","ERG3",6323085,19,24,0,0,"FA_hydroxylase","NA","cellular organisms","C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources"]
["YLR233C","EST1",6323262,19,5,0,0,"EST1~EST1_DNA_bind","NA","Saccharomycetales","TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere"]
["YLR298C","YHC1",6323329,19,10,0,0,"zf-U1","NA","Eukaryota","Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site"]
["YLR413W","YLR413W",6323445,19,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML012W","ERV25",6323630,19,12,0,0,"EMP24_GP25L","NA","Eukaryota","Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport"]
["YML057W","CMP2",6323583,19,11,0,0,"Metallophos","NA","cellular organisms","Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1"]
["YMR033W","ARP9",6323676,19,24,0,0,"NA","NA","Eukaryota","Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation"]
["YMR292W","GOT1",6323949,19,8,0,0,"Got1","NA","Eukaryota","Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p"]
["YNL064C","YDJ1",6324265,19,26,0,0,"DnaJ~DnaJ_CXXCXGXG~DnaJ_C","NA","cellular organisms","Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family"]
["YNL077W","APJ1",6324252,19,13,0,0,"DnaJ~DnaJ_CXXCXGXG","NA","cellular organisms","Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YNL082W","PMS1",46562124,19,10,0,0,"HATPase_c~DNA_mis_repair~MutL_C","NA","cellular organisms","ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL"]
["YOR051C","YOR051C",6324625,19,28,1,0,"NA","NA","Saccharomycetales","NA"]
["YOR211C","MGM1",116006501,19,7,0,0,"Dynamin_N~Miro","NA","Eukaryota","Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy"]
["YOR273C","TPO4",6324847,19,8,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily"]
["YOR368W","RAD17",6324944,19,17,0,0,"NA","NA","Ascomycota","Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins"]
["YPL045W","VPS16",6325212,19,25,0,0,"Vps16_N~Vps16_C","NA","Eukaryota","Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages"]
["YPL048W","CAM1",6325209,19,6,0,0,"GST_N~GST_C~EF1G","NA","cellular organisms","Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma"]
["YPL084W","BRO1",6325173,19,38,0,0,"BRO1","NA","Eukaryota","Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes"]
["YPL100W","ATG21",6325157,19,11,0,0,"WD40","NA","Eukaryota","Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein"]
["YPL165C","SET6",6325092,19,25,0,0,"SET","NA","Eukaryota","Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability"]
["YPR013C","YPR013C",6325270,19,7,1,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","NA"]
["YPR022C","YPR022C",6325279,19,6,1,0,"zf-C2H2~DUF2467","NA","Dikarya","NA"]
["YPR036W","VMA13",6325293,19,24,0,0,"V-ATPase_H","NA","Eukaryota","Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase"]
["YPR075C","OPY2",6325333,19,5,0,0,"Opy2","NA","Ascomycota","Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone"]
["YPR180W","AOS1",6325438,19,5,0,0,"ThiF","NA","cellular organisms","Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability"]
["YPR188C","MLC2",6325446,19,9,0,0,"efhand","NA","cellular organisms","Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring"]
["YDR430C","CYM1",6320639,19,12,0,1,"Peptidase_M16_C~M16C_assoc~Peptidase_M16_C","NA","cellular organisms","Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology"]
["YGL226W","YGL226W",6321212,19,6,0,1,"COX4","NA","Dikarya","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; YGL226W is synthetically sick with cdc13-1"]
["YGR235C","YGR235C",6321674,19,7,1,1,"DUF2412","NA","Dikarya","NA"]
["YIL114C","POR2",6322077,19,16,0,1,"Porin_3","NA","Eukaryota","Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability"]
["YKL192C","ACP1",6322656,19,2,0,1,"PP-binding","NA","cellular organisms","Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p"]
["YKR006C","MRPL13",37362673,19,33,0,1,"NA","NA","Saccharomycetales","Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"]
["YMR115W","FMP24",6323762,19,13,0,1,"NA","NA","Saccharomycetales","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YNL083W","SAL1",42742308,19,7,0,1,"efhand~Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains"]
["YAL007C","ERP2",6319312,18,7,0,0,"EMP24_GP25L","NA","Eukaryota","Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles"]
["YAL025C","MAK16",6319294,18,3,0,0,"Mak16","NA","Eukaryota","Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus"]
["YAL029C","MYO4",6319290,18,8,0,0,"Myosin_head~DIL","NA","Eukaryota","One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p"]
["YAL049C","AIM2",6319267,18,9,1,0,"DLH","NA","cellular organisms","Cytoplasmic protein of unknown function, potential Hsp82p interactor; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YBL051C","PIN4",6319420,18,35,0,0,"RRM_1","NA","Dikarya","Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage"]
["YBL063W","KIP1",6319408,18,5,0,0,"Kinesin","NA","Eukaryota","Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p"]
["YBR063C","YBR063C",6319538,18,11,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YBR199W","KTR4",6319676,18,18,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Eukaryota","Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"]
["YBR259W","YBR259W",6319736,18,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBR281C","DUG2",6319758,18,18,0,0,"WD40~Peptidase_M20~M20_dimer","NA","cellular organisms","Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)"]
["YCL025C","AGP1",85666113,18,7,0,0,"AA_permease","NA","cellular organisms","Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)"]
["YCR008W","SAT4",6319853,18,35,0,0,"Pkinase~Pkinase_Tyr~APH","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p"]
["YCR017C","CWH43",10383785,18,23,0,0,"Frag1","NA","cellular organisms","Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion"]
["YCR102C","YCR102C",6319945,18,4,1,0,"ADH_N~ADH_zinc_N","NA","cellular organisms","NA"]
["YCR105W","ADH7",6319949,18,7,0,0,"ADH_N~2-Hacid_dh_C~ADH_zinc_N","1.1.1.2_Alcohol dehydrogenase (NADP(+))","cellular organisms","NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance"]
["YDL072C","YET3",6320131,18,11,0,0,"Bap31","NA","Eukaryota","Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein"]
["YDL186W","YDL186W",6320014,18,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR004W","RAD57",6320207,18,20,0,0,"Rad51","NA","cellular organisms","Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p"]
["YDR014W","RAD61",6320217,18,11,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; mutation confers radiation sensitivity"]
["YDR167W","TAF10",6320371,18,14,0,0,"TFIID_30kDa","NA","Eukaryota","Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification"]
["YDR217C","RAD9",6320423,18,22,0,0,"Rad9_Rad53_bind~BRCT","NA","Ascomycota","DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate"]
["YDR315C","IPK1",6320521,18,6,0,0,"Ins_P5_2-kin","2.7.1.158_Inositol-pentakisphosphate 2-kinase","Saccharomycetales","Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable"]
["YDR428C","BNA7",6320636,18,4,0,0,"Abhydrolase_1","NA","cellular organisms","Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine"]
["YDR518W","EUG1",6320726,18,9,0,0,"Thioredoxin~Thioredoxin","5.3.4.1_Protein disulfide-isomerase","Eukaryota","Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER"]
["YER041W","YEN1",6320880,18,27,0,0,"XPG_I","NA","cellular organisms","Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p"]
["YER095W","RAD51",6320942,18,36,0,0,"Rad51","NA","cellular organisms","Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein"]
["YER106W","MAM1",6320953,18,4,0,0,"MAM1","NA","Saccharomycetaceae","Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle"]
["YER173W","RAD24",6321021,18,17,0,0,"Rad17","NA","Eukaryota","Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein"]
["YFR005C","SAD1",14318527,18,5,0,0,"UCH","NA","Eukaryota","Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle"]
["YGL131C","SNT2",6321307,18,2,0,0,"BAH~PHD~Myb_DNA-binding~PHD","NA","Dikarya","DNA binding protein with similarity to the S. pombe Snt2 protein"]
["YGL135W","RPL1B",6321303,18,2,0,0,"Ribosomal_L1","NA","cellular organisms","N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal"]
["YGL206C","CHC1",6321232,18,8,0,0,"Clathrin-link~Clathrin~Clathrin~Clathrin~Clathrin~Clathrin~Clathrin~Clathrin","NA","Eukaryota","Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function"]
["YGL212W","VAM7",6321226,18,31,0,0,"PX~SNARE","NA","Eukaryota","Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking"]
["YGL228W","SHE10",6321209,18,8,0,0,"NA","NA","Saccharomycetaceae","Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest"]
["YGR075C","PRP38",6321512,18,8,0,0,"PRP38","NA","Saccharomycetales","Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly"]
["YGR109C","CLB6",6321546,18,8,0,0,"Cyclin_N~Cyclin_C","NA","Eukaryota","B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1"]
["YGR258C","RAD2",6321697,18,15,0,0,"XPG_N~XPG_I","NA","cellular organisms","Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein"]
["YHR026W","PPA1",6321815,18,29,0,0,"ATP-synt_C","NA","cellular organisms","Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain"]
["YHR077C","NMD2",6579193,18,8,0,0,"MIF4G~MIF4G~MIF4G","NA","Eukaryota","Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance"]
["YHR081W","LRP1",6321873,18,11,0,0,"Sas10_Utp3","NA","Ascomycota","Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination"]
["YIL056W","VHR1",6322133,18,12,0,0,"Vhr1","NA","Saccharomycetales","Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations"]
["YIR018W","YAP5",6322208,18,13,0,0,"bZIP_1~DUF641","NA","Ascomycota","Basic leucine zipper (bZIP) transcription factor"]
["YIR034C","LYS1",6322225,18,7,0,0,"AlaDh_PNT_N~AlaDh_PNT_C","1.5.1.7_Saccharopine dehydrogenase (NAD(+), L-lysine-forming)","cellular organisms","Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway"]
["YJL044C","GYP6",6322417,18,5,0,0,"NA","NA","Eukaryota","GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport"]
["YKL072W","STB6",6322778,18,6,0,0,"NA","NA","Dikarya","Protein that binds Sin3p in a two-hybrid assay"]
["YKL078W","DHR2",6322772,18,2,0,0,"Helicase_C~HA2~DUF1605","NA","cellular organisms","Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis"]
["YKL107W","YKL107W",6322742,18,5,1,0,"adh_short~Epimerase~KR","NA","cellular organisms","NA"]
["YKL151C","YKL151C",6322698,18,6,1,0,"Carb_kinase","NA","cellular organisms","NA"]
["YLL002W","RTT109",6323027,18,11,0,0,"KAT11","NA","Ascomycota","Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition"]
["YLL005C","SPO75",6323024,18,8,0,0,"DUF221","NA","Eukaryota","Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"]
["YLL046C","RNP1",6322982,18,10,0,0,"RRM_1","NA","Eukaryota","Ribonucleoprotein that contains two RNA recognition motifs (RRM)"]
["YLR006C","SSK1",6323034,18,25,0,0,"Response_reg~Response_reg","NA","cellular organisms","Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate"]
["YLR037C","DAN2",6323066,18,11,0,0,"SRP1_TIP1","NA","Saccharomycetaceae","Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"]
["YLR098C","CHA4",6323127,18,6,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain"]
["YLR234W","TOP3",6323263,18,13,0,0,"Toprim~Topoisom_bac","5.99.1.2_DNA topoisomerase","cellular organisms","DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination"]
["YLR314C","CDC3",6323346,18,3,0,0,"Septin","NA","Eukaryota","Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"]
["YLR394W","CST9",6323426,18,3,0,0,"zf-MIZ","NA","Saccharomycetaceae","SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate"]
["YML017W","PSP2",41629688,18,22,0,0,"NA","NA","Saccharomycetaceae","Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing"]
["YML063W","RPS1B",6323577,18,6,0,0,"Ribosomal_S3Ae","NA","cellular organisms","Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein"]
["YML075C","HMG1",6323565,18,17,0,0,"HMG-CoA_red","NA","cellular organisms","One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae"]
["YML112W","CTK3",6323524,18,17,0,0,"NA","NA","Saccharomycetaceae","Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing"]
["YML131W","YML131W",6323504,18,7,1,0,"ADH_zinc_N","NA","cellular organisms","NA"]
["YMR187C","YMR187C",6323841,18,14,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR199W","CLN1",6323855,18,16,0,0,"Cyclin_N","NA","Dikarya","G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)"]
["YNL155W","YNL155W",6324174,18,7,1,0,"zf-AN1","NA","Eukaryota","NA"]
["YOL034W","SMC5",6324539,18,5,0,0,"SMC_N~NACHT","NA","cellular organisms","Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair"]
["YOL147C","PEX11",6324425,18,6,0,0,"PEX11","NA","Eukaryota","Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements"]
["YOR068C","VAM10",6324642,18,32,0,0,"NA","NA","Saccharomyces cerevisiae","Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering"]
["YOR084W","LPX1",6324658,18,6,0,0,"NA","NA","Fungi/Metazoa group","Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction"]
["YOR106W","VAM3",6324680,18,25,0,0,"Syntaxin~SNARE","NA","Eukaryota","Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins"]
["YOR246C","YOR246C",6324820,18,18,1,0,"NA","NA","cellular organisms","NA"]
["YOR283W","YOR283W",6324857,18,6,1,0,"PGAM","NA","cellular organisms","NA"]
["YOR383C","FIT3",6324959,18,21,0,0,"NA","NA","Saccharomycetaceae","Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"]
["YPL024W","RMI1",6325233,18,12,0,0,"NA","NA","Ascomycota","Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)"]
["YPL179W","PPQ1",6325078,18,19,0,0,"Metallophos","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors"]
["YPL210C","SRP72",37362700,18,3,0,0,"TPR_2~SRP72","NA","Eukaryota","Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane"]
["YPR073C","LTP1",6325330,18,4,0,0,"LMWPc","3.1.3.2_Acid phosphatase|3.1.3.48_Protein-tyrosine-phosphatase","cellular organisms","Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine"]
["YGR101W","PCP1",6321538,18,9,0,1,"Rhomboid","3.4.21.105_Rhomboid protease","cellular organisms","Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases"]
["YGR207C","YGR207C",6321646,18,6,0,1,"ETF","NA","cellular organisms","NA"]
["YIL094C","LYS12",6322097,18,3,0,1,"Iso_dh","NA","cellular organisms","Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"]
["YKR036C","CAF4",99030928,18,7,0,1,"WD40~WD40~WD40~WD40","NA","cellular organisms","WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission"]
["YMR064W","AEP1",6323709,18,8,0,1,"NA","NA","Saccharomycetaceae","Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase"]
["YOR271C","FSF1",6324845,18,13,1,1,"Mtc","NA","Eukaryota","Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis"]
["YPL083C","SEN54",6325174,18,5,0,1,"NA","NA","Fungi/Metazoa group","Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p"]
["YPL135W","ISU1",6325122,18,21,0,1,"NifU_N","NA","cellular organisms","Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable"]
["YAL053W","FLC2",6319265,17,24,0,0,"TRP","NA","Dikarya","Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance"]
["YAR031W","PRM9",6319334,17,4,0,0,"DUP","NA","Saccharomycetaceae","Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family"]
["YBL102W","SFT2",6319366,17,9,0,0,"SFT2","NA","Eukaryota","Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5"]
["YBR020W","GAL1",6319494,17,35,0,0,"GalKase_gal_bdg~GHMP_kinases_N~GHMP_kinases_C~Peptidase_M16_C","2.7.1.6_Galactokinase","cellular organisms","Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p"]
["YBR025C","OLA1",6319499,17,4,0,0,"MMR_HSR1~YchF-GTPase_C~SecA_PP_bind","NA","cellular organisms","P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide"]
["YBR217W","ATG12",6319694,17,12,0,0,"APG12","NA","Eukaryota","Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation"]
["YBR237W","PRP5",6319714,17,2,0,0,"DEAD~Helicase_C","NA","cellular organisms","RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA"]
["YCR066W","RAD18",6319911,17,27,0,0,"zf-C3HC4~GAGA~SAP","NA","Eukaryota","Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif"]
["YDL123W","SNA4",6320080,17,5,0,0,"UPF0057","NA","cellular organisms","Protein of unknown function, localized to the vacuolar outer membrane"]
["YDL155W","CLB3",6320046,17,10,0,0,"Cyclin_N~Cyclin_C","NA","Eukaryota","B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation"]
["YDL215C","GDH2",6319986,17,10,0,0,"ELFV_dehydrog","1.4.1.2_Glutamate dehydrogenase","cellular organisms","NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels"]
["YDL241W","YDL241W",6319960,17,8,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDR155C","CPR1",6320359,17,8,0,0,"Pro_isomerase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A"]
["YDR259C","YAP6",6320465,17,18,0,0,"bZIP_1","NA","Eukaryota","Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance"]
["YDR345C","HXT3",6320552,17,11,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions"]
["YDR438W","THI74",6320646,17,11,0,0,"DUF6","NA","cellular organisms","Mitochondrial transporter repressible by thiamine"]
["YDR448W","ADA2",6320656,17,12,0,0,"ZZ~Myb_DNA-binding~SWIRM","NA","Eukaryota","Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes"]
["YDR486C","VPS60",37362639,17,26,0,0,"Snf7","NA","Eukaryota","Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p"]
["YEL054C","RPL12A",6320781,17,7,0,0,"Ribosomal_L11_N~Ribosomal_L11","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins"]
["YER120W","SCS2",6320966,17,28,0,0,"Motile_Sperm","NA","Eukaryota","Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog"]
["YER144C","UBP5",6320992,17,6,0,0,"Rhodanese~UCH","3.1.2.15_Ubiquitin thiolesterase","Eukaryota","Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck"]
["YGL083W","SCY1",6321355,17,11,0,0,"Pkinase~Pkinase","NA","cellular organisms","Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase"]
["YGL090W","LIF1",6321348,17,9,0,0,"XLF","NA","Saccharomycetaceae","Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein"]
["YGR142W","BTN2",6321581,17,7,0,0,"NA","NA","Saccharomycetaceae","v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase"]
["YGR275W","RTT102",37362657,17,5,0,0,"Rtt102p","NA","Saccharomycetaceae","Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition"]
["YHL029C","OCA5",6321758,17,30,1,0,"NA","NA","Saccharomycetales","Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"]
["YIL009C-A","EST3",6322181,17,10,0,0,"Est3","NA","Saccharomycetales","Component of the telomerase holoenzyme, involved in telomere replication"]
["YIL117C","PRM5",6322074,17,7,0,0,"NA","NA","Ascomycota","Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling"]
["YIL140W","AXL2",6322051,17,9,0,0,"DAG1~He_PIG~He_PIG~SKG6","NA","Dikarya","Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate"]
["YIL149C","MLP2",6322042,17,8,0,0,"TPR_MLP1_2","NA","Dikarya","Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length"]
["YIR019C","MUC1",6322209,17,16,0,0,"Flo11","NA","cellular organisms","GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)"]
["YJL003W","COX16",6322457,17,7,0,0,"NA","NA","Dikarya","Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase"]
["YJL020C","BBC1",14627173,17,24,0,0,"SH3_1~SH3_2","NA","Ascomycota","Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches"]
["YJL056C","ZAP1",6322405,17,8,0,0,"zf-C2H2~zf-C2H2~zf-C2H2~zf-C2H2~zf-C2H2~zf-C2H2","NA","Eukaryota","Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains"]
["YJL088W","ARG3",6322373,17,7,0,0,"OTCace_N~OTCace","2.1.3.3_Ornithine carbamoyltransferase","cellular organisms","Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine"]
["YJL100W","LSB6",6322361,17,5,0,0,"PI3_PI4_kinase","2.7.1.67_1-phosphatidylinositol 4-kinase","Fungi/Metazoa group","Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"]
["YJL201W","ECM25",6322260,17,27,0,0,"NA","NA","Eukaryota","Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p"]
["YKL006W","RPL14A",6322847,17,9,0,0,"KOW~Ribosomal_L14e","NA","cellular organisms","N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth"]
["YKL024C","URA6",6322828,17,2,0,0,"ADK","NA","cellular organisms","Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)"]
["YKL075C","YKL075C",6322775,17,23,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKL094W","YJU3",6322756,17,9,0,0,"Abhydrolase_1","NA","cellular organisms","Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles"]
["YKL127W","PGM1",6322722,17,18,0,0,"PGM_PMM_I~PGM_PMM_II~PGM_PMM_III~PGM_PMM_IV","5.4.2.2_Phosphoglucomutase","cellular organisms","Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism"]
["YKL196C","YKT6",6322652,17,4,0,0,"Synaptobrevin~Synaptobrevin","NA","Eukaryota","Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus"]
["YKR054C","DYN1",6322907,17,12,0,0,"DHC_N1~DHC_N2~AAA_5~Mg_chelatase~Dynein_heavy~Dynein_heavy","NA","Eukaryota","Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p"]
["YLL055W","YCT1",6322973,17,4,0,0,"MFS_1","NA","cellular organisms","High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene"]
["YLR181C","VTA1",6323210,17,27,0,0,"DUF605","NA","Fungi/Metazoa group","Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain"]
["YLR225C","YLR225C",6323254,17,11,1,0,"Svf1","NA","Ascomycota","NA"]
["YLR408C","YLR408C",6323440,17,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML020W","YML020W",6323621,17,9,1,0,"NA","NA","Dikarya","NA"]
["YML053C","YML053C",6323588,17,2,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YML070W","DAK1",6323570,17,3,0,0,"Dak1~Dak2","2.7.1.29_Glycerone kinase","cellular organisms","Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation"]
["YML095C","RAD10",6323543,17,22,0,0,"Rad10","NA","Eukaryota","Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein"]
["YML099C","ARG81",6323539,17,11,0,0,"Zn_clus","NA","Ascomycota","Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p"]
["YMR005W","TAF4",6323647,17,5,0,0,"TAF4","NA","Fungi/Metazoa group","TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate"]
["YMR034C","YMR034C",6323677,17,2,1,0,"NA","NA","cellular organisms","NA"]
["YMR044W","IOC4",6323687,17,8,0,0,"PWWP","NA","Saccharomycetales","Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif"]
["YMR054W","STV1",6323699,17,9,0,0,"V_ATPase_I","NA","cellular organisms","Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole"]
["YMR091C","NPL6",6323738,17,13,0,0,"CRC_subunit","NA","Dikarya","Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length"]
["YMR139W","RIM11",6323788,17,14,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta"]
["YMR285C","NGL2",6323941,17,12,0,0,"Exo_endo_phos","NA","Eukaryota","Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p"]
["YMR298W","LIP1",6323956,17,3,0,0,"NA","NA","Saccharomycetaceae","Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis"]
["YNL044W","YIP3",6681850,17,17,0,0,"PRA1","NA","Eukaryota","Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p"]
["YNL090W","RHO2",6324239,17,11,0,0,"Miro~Ras","NA","cellular organisms","Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly"]
["YNL167C","SKO1",6324162,17,15,0,0,"bZIP_2~bZIP_1","NA","Ascomycota","Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses"]
["YNL175C","NOP13",6324155,17,15,0,0,"RRM_1~RRM_1","NA","Eukaryota","Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA"]
["YNL191W","DUG3",6324138,17,10,0,0,"NA","NA","cellular organisms","Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)"]
["YNL219C","ALG9",6324110,17,10,0,0,"Glyco_transf_22","NA","Eukaryota","Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation"]
["YNL255C","GIS2",6324074,17,9,0,0,"zf-CCHC~zf-CCHC~zf-CCHC~zf-CCHC~zf-CCHC~zf-CCHC~zf-CCHC","NA","Eukaryota","Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway"]
["YNL257C","SIP3",6324072,17,24,0,0,"PH","NA","Ascomycota","Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate"]
["YNL300W","YNL300W",6324029,17,12,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YNL327W","EGT2",6324002,17,5,0,0,"NA","NA","Saccharomycetaceae","Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner"]
["YNL329C","PEX6",6324000,17,14,0,0,"AAA~Parvo_NS1~IstB~AAA_2~AAA~AAA_3~Mg_chelatase","NA","cellular organisms","AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol"]
["YNR055C","HOL1",6324383,17,9,0,0,"MFS_1","NA","Eukaryota","Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake"]
["YNR070W","YNR070W",6324398,17,10,1,0,"ABC_tran~ABC2_membrane~PDR_CDR~DUF258~ABC_tran~MMR_HSR1~Septin~ABC2_membrane","NA","cellular organisms","NA"]
["YOL133W","HRT1",6324438,17,5,0,0,"zf-C3HC4","NA","Eukaryota","RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF"]
["YOL151W","GRE2",6324421,17,7,0,0,"Epimerase","1.1.1.283_Methylglyoxal reductase (NADPH-dependent)","cellular organisms","3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway"]
["YOR304C-A","YOR304C-A",6324880,17,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL039W","YPL039W",6325218,17,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL065W","VPS28",6325192,17,58,0,0,"VPS28","NA","Eukaryota","Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole"]
["YPL103C","FMP30",6325154,17,20,0,0,"NA","NA","cellular organisms","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YPL110C","GDE1",6325147,17,8,0,0,"SPX~SPX~Ank~Ank~GDPD","3.1.4.46_Glycerophosphodiester phosphodiesterase","cellular organisms","Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes"]
["YPL167C","REV3",6325090,17,16,0,0,"DNA_pol_B_exo~DNA_pol_B_exo~DNA_pol_B","2.7.7.7_DNA-directed DNA polymerase","cellular organisms","Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage"]
["YPL245W","YPL245W",6325011,17,6,1,0,"DUF2075","NA","cellular organisms","NA"]
["YPL249C","GYP5",6325007,17,8,0,0,"TBC","NA","Eukaryota","GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p"]
["YPR056W","TFB4",6325313,17,3,0,0,"Tfb4","NA","Eukaryota","Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p"]
["YPR108W","RPN7",6325365,17,2,0,0,"RPN7~TPR_1~PCI","NA","Eukaryota","Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits"]
["YBR026C","ETR1",6319500,17,3,0,1,"NA","1.3.1.10_Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)|1.3.1.38_Trans-2-enoyl-CoA reductase (NADPH)","cellular organisms","2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis"]
["YDR305C","HNT2",6320511,17,10,0,1,"HIT","NA","cellular organisms","Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins"]
["YJR077C","MIR1",6322537,17,10,0,1,"Mito_carr~Mito_carr~Mito_carr~DUF637","NA","Eukaryota","Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated"]
["YKL157W","APE2",9755335,17,9,0,1,"Peptidase_M1","NA","cellular organisms","Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W"]
["YLL001W","DNM1",6323028,17,15,0,1,"Dynamin_N~Miro~Dynamin_M~GED","3.6.5.5_Dynamin GTPase","Eukaryota","Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis"]
["YLR295C","ATP14",6323326,17,5,0,1,"ATP_sub_h","NA","Ascomycota","Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YLR348C","DIC1",6323381,17,9,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix"]
["YMR207C","HFA1",6323863,17,8,0,1,"CPSase_L_chain~CPSase_L_D2~Biotin_carb_C~Biotin_lipoyl~ACC_central~Carboxyl_trans","6.3.4.14_Biotin carboxylase|6.4.1.2_Acetyl-CoA carboxylase","cellular organisms","Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis"]
["YMR241W","YHM2",6323897,17,7,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","cellular organisms","Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family"]
["YMR302C","YME2",6323960,17,10,0,1,"RRM_1~RNA12","NA","Eukaryota","Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases"]
["YNL310C","ZIM17",99030930,17,4,0,1,"zf-DNL","NA","Eukaryota","Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix"]
["YOR022C","YOR022C",6324596,17,8,1,1,"DDHD","NA","Eukaryota","NA"]
["YOR147W","MDM32",83578106,17,13,0,1,"MDM31_MDM32~MDM31_MDM32~MDM31_MDM32","NA","Eukaryota","Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34"]
["YOR266W","PNT1",6324840,17,14,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine"]
["YAL002W","VPS8",41629668,16,39,0,0,"Clathrin","NA","Fungi/Metazoa group","Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif"]
["YAR020C","PAU7",6319329,16,12,0,0,"SRP1_TIP1","NA","Saccharomyces cerevisiae","Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme"]
["YBL031W","SHE1",6319440,16,32,0,0,"NA","NA","Saccharomycetaceae","Cytoskeletal protein of unknown function; overexpression causes growth arrest"]
["YBL034C","STU1",6319437,16,4,0,0,"NA","NA","Ascomycota","Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles"]
["YBR212W","NGR1",6319689,16,11,0,0,"RRM_1~RRM_1~RRM_1","NA","Eukaryota","RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase"]
["YBR214W","SDS24",6319691,16,8,0,0,"CBS~CBS~CBS","NA","Eukaryota","One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis"]
["YCL024W","KCC4",10383767,16,6,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p"]
["YCR020W-B","HTL1",6319868,16,8,0,0,"NA","NA","Saccharomycetaceae","Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance"]
["YCR091W","KIN82",10383810,16,4,0,0,"Pkinase","NA","cellular organisms","Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily"]
["YDL077C","VAM6",6320126,16,30,0,0,"Vps39_1~Vps39_2","NA","Eukaryota","Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p"]
["YDL129W","YDL129W",6320074,16,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDL148C","NOP14",6320053,16,3,0,0,"Nop14~DUF1351","NA","Eukaryota","Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA"]
["YDR080W","VPS41",6320285,16,18,0,0,"WD40~Clathrin","NA","Eukaryota","Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport"]
["YDR113C","PDS1",6320318,16,3,0,0,"Securin","NA","Saccharomycetaceae","Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei"]
["YDR176W","NGG1",6320381,16,24,0,0,"Ada3","NA","Dikarya","Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex"]
["YDR249C","YDR249C",6320455,16,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR291W","HRQ1",6320497,16,9,1,0,"DEAD~Helicase_C~DUF1998","NA","cellular organisms","Putative DNA helicase"]
["YDR339C","FCF1",6320546,16,10,0,0,"Fcf1","NA","cellular organisms","Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p"]
["YDR378C","LSM6",82795247,16,16,0,0,"LSM","NA","Eukaryota","Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"]
["YDR434W","GPI17",6320642,16,3,0,0,"PIG-S","NA","Eukaryota","Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog"]
["YDR513W","GRX2",6320720,16,7,0,0,"Glutaredoxin","NA","cellular organisms","Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress"]
["YDR522C","SPS2",6320730,16,9,0,0,"Recep_L_domain","NA","Ascomycota","Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component"]
["YER004W","FMP52",6320840,16,5,0,0,"HIM1","NA","cellular organisms","Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation"]
["YER071C","YER071C",6320915,16,8,1,0,"NA","NA","Saccharomycetales","NA"]
["YER096W","SHC1",6320943,16,4,0,0,"Sel1~Sel1","NA","cellular organisms","Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH"]
["YER131W","RPS26B",6320978,16,7,0,0,"Ribosomal_S26e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein"]
["YER162C","RAD4",6321010,16,13,0,0,"Transglut_core~Rad4~BHD_1~BHD_2~BHD_3","NA","Eukaryota","Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein"]
["YFR014C","CMK1",14318536,16,6,0,0,"Pkinase~Pkinase_Tyr","2.7.11.17_Calcium/calmodulin-dependent protein kinase","cellular organisms","Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II"]
["YFR017C","YFR017C",14318539,16,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGL016W","KAP122",6321422,16,7,0,0,"NA","NA","Ascomycota","Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance"]
["YGL179C","TOS3",6321259,16,2,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"]
["YGL201C","MCM6",41629691,16,4,0,0,"MCM","NA","cellular organisms","Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex"]
["YGL226C-A","OST5",6321211,16,6,0,0,"NA","2.4.1.119_Dolichyl-diphosphooligosaccharide--protein glycotransferase","Saccharomycetaceae","Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"]
["YGR005C","TFG2",6321442,16,4,0,0,"TFIIF_beta","NA","Eukaryota","TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30"]
["YGR023W","MTL1",6321459,16,7,0,0,"Mid2","NA","Saccharomyces cerevisiae","Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations"]
["YGR024C","THG1",6321461,16,6,0,0,"Thg1","NA","cellular organisms","tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes"]
["YGR048W","UFD1",6321485,16,8,0,0,"UFD1","NA","Eukaryota","Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol"]
["YHR104W","GRE3",6321896,16,30,0,0,"Aldo_ket_red","1.1.1.21_Aldehyde reductase","cellular organisms","Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway"]
["YHR111W","UBA4",6321903,16,10,0,0,"Shikimate_DH~ThiF~MoeZ_MoeB~Rhodanese","NA","cellular organisms","Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response"]
["YHR132C","ECM14",6321924,16,15,0,0,"Peptidase_M14","NA","cellular organisms","Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly"]
["YIL035C","CKA1",6322154,16,29,0,0,"Pkinase~APH~Pkinase","NA","cellular organisms","Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases"]
["YIL039W","TED1",6322150,16,8,1,0,"Metallophos","NA","Eukaryota","Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"]
["YIL090W","ICE2",6322101,16,12,0,0,"ICE2","NA","Ascomycota","Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells"]
["YIL122W","POG1",6322069,16,11,0,0,"NA","NA","Saccharomycetaceae","Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated"]
["YIL137C","TMA108",6322054,16,18,0,0,"Peptidase_M1","NA","cellular organisms","Protein that associates with ribosomes; putative metalloprotease"]
["YJL174W","KRE9",6322287,16,10,0,0,"KRE9","NA","Ascomycota","Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects"]
["YJR078W","BNA2",6322538,16,8,0,0,"IDO","NA","cellular organisms","Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p"]
["YJR083C","ACF4",6322542,16,27,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate"]
["YJR127C","RSF2",6322588,16,24,0,0,"zf-C2H2~DUF2467","NA","Ascomycota","Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions"]
["YKL079W","SMY1",6322771,16,17,0,0,"Kinesin","NA","Eukaryota","Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins"]
["YKL088W","YKL088W",6322762,16,3,1,0,"Flavoprotein","NA","cellular organisms","NA"]
["YKL133C","YKL133C",6322716,16,3,1,0,"NA","NA","Ascomycota","NA"]
["YKL143W","LTV1",6322706,16,12,0,0,"LTV","NA","Fungi/Metazoa group","Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature"]
["YLR018C","POM34",6323046,16,10,0,0,"NPCC~CytochromB561_N","NA","Saccharomycetaceae","Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex"]
["YLR035C","MLH2",6323063,16,8,0,0,"HATPase_c~DNA_mis_repair","NA","cellular organisms","Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p"]
["YLR060W","FRS1",6323089,16,3,0,0,"B3_4~B5","6.1.1.20_Phenylalanine--tRNA ligase","cellular organisms","Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar"]
["YLR128W","DCN1",6323157,16,12,0,0,"DUF298","NA","Eukaryota","Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain"]
["YLR146C","SPE4",6323175,16,5,0,0,"Spermine_synth","2.5.1.22_Spermine synthase","cellular organisms","Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid"]
["YLR152C","YLR152C",6323181,16,9,1,0,"Mem_trans~Mem_trans","NA","Eukaryota","NA"]
["YLR214W","FRE1",6323243,16,6,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","Eukaryota","Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels"]
["YLR257W","YLR257W",6323286,16,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLR305C","STT4",6323336,16,5,0,0,"PI3Ka~PI3_PI4_kinase","2.7.1.67_1-phosphatidylinositol 4-kinase","Eukaryota","Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization"]
["YLR361C","DCR2",6323393,16,13,0,0,"Metallophos","NA","cellular organisms","Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START"]
["YLR387C","REH1",6323419,16,4,0,0,"NA","NA","Eukaryota","Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains"]
["YLR435W","TSR2",37362680,16,11,0,0,"WGG","NA","Eukaryota","Protein with a potential role in pre-rRNA processing"]
["YLR447C","VMA6",6323480,16,18,0,0,"vATP-synt_AC39","NA","cellular organisms","Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane"]
["YLR449W","FPR4",6323482,16,5,0,0,"FKBP_C","NA","cellular organisms","Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones"]
["YMR069W","NAT4",6323714,16,4,0,0,"Acetyltransf_1~FR47","NA","cellular organisms","N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A"]
["YMR101C","SRT1",6323748,16,5,0,0,"Prenyltransf","NA","cellular organisms","Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase"]
["YMR294W","JNM1",6323951,16,30,0,0,"NA","NA","Saccharomycetales","Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B"]
["YNL101W","AVT4",6324228,16,12,0,0,"Aa_trans","NA","Eukaryota","Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"]
["YNL116W","DMA2",6324213,16,9,0,0,"FHA","NA","Dikarya","Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr."]
["YNL250W","RAD50",6324079,16,21,0,0,"SMC_N~DUF733~Rad50_zn_hook~ABC_tran","NA","cellular organisms","Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining"]
["YNL316C","PHA2",37362685,16,11,0,0,"PDT~PDT","4.2.1.51_Prephenate dehydratase","cellular organisms","Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway"]
["YNR013C","PHO91",6324340,16,10,0,0,"SPX","NA","cellular organisms","Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"]
["YNR023W","SNF12",6324350,16,15,0,0,"NA","NA","Eukaryota","73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive"]
["YNR069C","BSC5",6324397,16,7,0,0,"Bul1_N","NA","Saccharomycetales","Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"]
["YOL068C","HST1",6324504,16,14,0,0,"DUF592~SIR2","NA","cellular organisms","NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance"]
["YOL070C","NBA1",6324502,16,17,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate"]
["YOL119C","MCH4",6324453,16,6,0,0,"MFS_1","NA","cellular organisms","Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"]
["YOL148C","SPT20",6324424,16,13,0,0,"NA","NA","Ascomycota","Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex"]
["YOR030W","DFG16",6324604,16,25,0,0,"PalH","NA","Saccharomycetales","Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p"]
["YOR137C","SIA1",6324711,16,6,0,0,"Metallophos","NA","cellular organisms","Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose"]
["YOR259C","RPT4",6324833,16,17,0,0,"AAA_2~IstB~AAA~AAA_3~AAA_5~Parvo_NS1~Mg_chelatase~Sigma54_activat","NA","cellular organisms","One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle"]
["YOR301W","RAX1",6324876,16,8,0,0,"RGS","NA","Dikarya","Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily"]
["YPL061W","ALD6",6325196,16,9,0,0,"Aldedh","NA","cellular organisms","Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress"]
["YPL108W","YPL108W",6325149,16,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL120W","VPS30",6325137,16,47,0,0,"APG6","NA","Eukaryota","Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1"]
["YPL187W","MF(ALPHA)1",6325069,16,8,0,0,"MF_alpha_N~MF_alpha~MF_alpha~MF_alpha~MF_alpha","NA","Saccharomycetales","Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor"]
["YPL196W","OXR1",6325060,16,8,0,0,"TLD~TLD","NA","Eukaryota","Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes"]
["YPL202C","AFT2",6325054,16,16,0,0,"AFT","NA","Saccharomycetaceae","Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p"]
["YPL204W","HRR25",6325052,16,16,0,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)"]
["YPL206C","YPL206C",6325050,16,6,0,0,"GDPD","NA","cellular organisms","Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs"]
["YPR183W","DPM1",6325441,16,6,0,0,"Glycos_transf_2","2.4.1.83_Dolichyl-phosphate beta-D-mannosyltransferase","cellular organisms","Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation"]
["YBL022C","PIM1",6319449,16,31,0,1,"LON~AAA~AAA_2~AAA_5~SKI~Lon_C","NA","cellular organisms","ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria"]
["YBL064C","PRX1",6319407,16,16,0,1,"AhpC-TSA~Redoxin~1-cysPrx_C","1.11.1.15_Peroxiredoxin","cellular organisms","Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated"]
["YBR085W","AAC3",6319560,16,4,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration"]
["YGR183C","QCR9",6321622,16,8,0,1,"UCR_UQCRX_QCR9","NA","Eukaryota","Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex"]
["YGR286C","BIO2",6321725,16,10,0,1,"Radical_SAM~BATS","2.8.1.6_Biotin synthase","cellular organisms","Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant"]
["YIL125W","KGD1",6322066,16,12,0,1,"E1_dh~Transket_pyr","1.2.4.2_Oxoglutarate dehydrogenase (succinyl-transferring)","cellular organisms","Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA"]
["YIL155C","GUT2",6322036,16,8,0,1,"HI0933_like~DAO~FAD_binding_2~Pyr_redox_2~FAD_binding_2","1.1.99.5_Glycerol-3-phosphate dehydrogenase","cellular organisms","Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner"]
["YLR142W","PUT1",6323171,16,12,0,1,"Pro_dh","1.5.99.8_Proline dehydrogenase","cellular organisms","Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source"]
["YLR188W","MDL1",6323217,16,6,0,1,"ABC_membrane~ABC_tran~APS_kinase","NA","Saccharomyces cerevisiae","Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress"]
["YLR369W","SSQ1",6323401,16,9,0,1,"HSP70~FGGY_C","NA","cellular organisms","Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia"]
["YMR003W","AIM34",6323645,16,5,1,1,"SAP","NA","Saccharomycetaceae","Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YMR062C","ECM40",6323707,16,5,0,1,"ArgJ","2.3.1.1_Amino-acid N-acetyltransferase|2.3.1.35_Glutamate N-acetyltransferase","cellular organisms","Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine"]
["YOR221C","MCT1",83578107,16,20,0,1,"NA","2.3.1.39_[Acyl-carrier-protein] S-malonyltransferase","cellular organisms","Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling"]
["YPL215W","CBP3",6325041,16,6,0,1,"Ubiq_cyt_C_chap","NA","cellular organisms","Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p"]
["YAL033W","POP5",6319286,15,7,0,0,"RNase_P_Rpp14","3.1.26.5_Ribonuclease P","Eukaryota","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"]
["YAR050W","FLO1",6319341,15,8,0,0,"PA14~PA14_2~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin~Flocculin","NA","cellular organisms","Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p"]
["YBL047C","EDE1",6319424,15,25,0,0,"efhand~efhand~UBA","NA","Eukaryota","Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins"]
["YBR024W","SCO2",6319498,15,7,0,0,"SCO1-SenC","NA","cellular organisms","Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p"]
["YBR035C","PDX3",6319509,15,12,0,0,"Pyridox_oxidase~PNPOx_C","1.4.3.5_Pyridoxal 5'-phosphate synthase","cellular organisms","Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism"]
["YBR077C","SLM4",6319551,15,23,0,0,"NA","NA","Saccharomycetaceae","Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4"]
["YBR157C","ICS2",41629678,15,5,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization"]
["YBR267W","REI1",6319743,15,9,0,0,"NA","NA","Eukaryota","Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network"]
["YCR026C","NPP1",10383789,15,21,0,0,"Phosphodiest","3.1.4.1_Phosphodiesterase I|3.6.1.9_Nucleotide diphosphatase","cellular organisms","Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation"]
["YCR073C","SSK22",10383805,15,7,0,0,"Pkinase~Pkinase_Tyr","NA","Eukaryota","MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p"]
["YDL118W","YDL118W",6320084,15,11,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDL137W","ARF2",6320064,15,8,0,0,"Arf~SRPRB~Miro~SRP54","NA","cellular organisms","ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p"]
["YDR037W","KRS1",6320242,15,3,0,0,"tRNA_anti~tRNA-synt_2","6.1.1.6_Lysine--tRNA ligase","cellular organisms","Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis"]
["YDR139C","RUB1",9755329,15,9,0,0,"ubiquitin","NA","cellular organisms","Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)"]
["YDR515W","SLF1",6320723,15,9,0,0,"La","NA","Saccharomycetaceae","RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts"]
["YDR530C","APA2",6320739,15,10,0,0,"ATP_transf","2.7.7.53_ATP adenylyltransferase","cellular organisms","Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p"]
["YDR541C","YDR541C",6320750,15,4,1,0,"Epimerase","NA","cellular organisms","NA"]
["YEL005C","VAB2",6320832,15,10,0,0,"FlaC_arch","NA","Saccharomycetaceae","Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YEL020C","YEL020C",6320816,15,12,1,0,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","NA","cellular organisms","NA"]
["YEL036C","ANP1",6320799,15,28,0,0,"Anp1","NA","Eukaryota","Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol"]
["YEL064C","AVT2",6320771,15,12,0,0,"Aa_trans","NA","Eukaryota","Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"]
["YER075C","PTP3",6320919,15,10,0,0,"Rhodanese~Y_phosphatase~Y_phosphatase","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm"]
["YER142C","MAG1",6320990,15,9,0,0,"HhH-GPD","3.2.2.21_DNA-3-methyladenine glycosylase II","cellular organisms","3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired"]
["YFL047W","RGD2",16198342,15,7,0,0,"FCH~DEP~RhoGAP","NA","Dikarya","GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p"]
["YGL122C","NAB2",6321316,15,3,0,0,"NA","NA","Eukaryota","Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export"]
["YGL196W","DSD1",50593216,15,11,0,0,"Ala_racemase_N","NA","cellular organisms","D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia; specifc for D-serine, unlike the bacterial enzyme which recognizes both D-serine and L-serine as substrates"]
["YGR153W","YGR153W",6321592,15,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGR170W","PSD2",6321609,15,26,0,0,"C2~C2~PS_Dcarbxylase","4.1.1.65_Phosphatidylserine decarboxylase","Eukaryota","Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine"]
["YGR188C","BUB1",6321627,15,16,0,0,"Mad3_BUB1_I~Mad3_BUB1_II~Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p"]
["YHL007C","STE20",6321780,15,18,0,0,"PBD~Pkinase~Pkinase_Tyr","NA","cellular organisms","Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases"]
["YHR074W","QNS1",6321865,15,7,0,0,"CN_hydrolase~NAD_synthase","6.3.5.1_NAD(+) synthase (glutamine-hydrolyzing)","cellular organisms","Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide"]
["YHR097C","YHR097C",6321889,15,7,1,0,"Pal1","NA","Dikarya","NA"]
["YHR100C","YHR100C",6321892,15,10,1,0,"DUF2010","NA","cellular organisms","NA"]
["YHR139C","SPS100",6321931,15,5,0,0,"NA","NA","cellular organisms","Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall"]
["YHR207C","SET5",6322001,15,29,0,0,"SET~SET","NA","Eukaryota","Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus"]
["YIL095W","PRK1",6322096,15,19,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex"]
["YIL119C","RPI1",6322072,15,7,0,0,"NA","NA","Saccharomycetaceae","Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation"]
["YIR003W","AIM21",6322193,15,15,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YJL047C","RTT101",6322414,15,14,0,0,"Cullin","NA","Dikarya","Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p"]
["YJL105W","SET4",6322356,15,11,0,0,"PHD~SET","NA","Fungi/Metazoa group","Protein of unknown function, contains a SET domain"]
["YJL155C","FBP26",6322306,15,30,0,0,"6PF2K~PGAM","3.1.3.46_Fructose-2,6-bisphosphate 2-phosphatase","cellular organisms","Fructose-2,6-bisphosphatase, required for glucose metabolism"]
["YJR032W","CPR7",6322492,15,6,0,0,"Pro_isomerase~TPR_1~TPR_2","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity"]
["YJR137C","ECM17",14318438,15,16,0,0,"Flavodoxin_1~NIR_SIR_ferr~NIR_SIR~NIR_SIR_ferr","NA","cellular organisms","Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine"]
["YJR147W","HMS2",6322607,15,10,0,0,"HSF_DNA-bind","NA","Eukaryota","Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant"]
["YKL015W","PUT3",6322837,15,4,0,0,"Zn_clus~Fungal_trans","NA","Ascomycota","Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain"]
["YKL025C","PAN3",6322827,15,20,0,0,"Pkinase","NA","Eukaryota","Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes"]
["YKL059C","MPE1",6322791,15,6,0,0,"DWNN~zf-CCHC","NA","Eukaryota","Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif"]
["YKL093W","MBR1",6322757,15,5,0,0,"NA","NA","Saccharomycetaceae","Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants"]
["YKL214C","YRA2",6322635,15,5,0,0,"RRM_1","NA","Saccharomycetaceae","Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus"]
["YLR058C","SHM2",6323087,15,9,0,0,"SHMT","2.1.2.1_Glycine hydroxymethyltransferase","cellular organisms","Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis"]
["YLR109W","AHP1",6323138,15,13,0,0,"Redoxin~AhpC-TSA","1.11.1.15_Peroxiredoxin","cellular organisms","Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p"]
["YLR114C","AVL9",6323143,15,14,0,0,"Avl9","NA","Eukaryota","Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms"]
["YLR138W","NHA1",6323167,15,11,0,0,"Na_H_Exchanger~Nha1_C","NA","cellular organisms","Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH"]
["YLR143W","YLR143W",6323172,15,9,1,0,"ATP_bind_4~ATP_bind_4~ATP_bind_4~Ribonuc_L-PSP~Ribonuc_L-PSP","NA","cellular organisms","NA"]
["YLR326W","YLR326W",6323358,15,11,1,0,"NA","NA","cellular organisms","NA"]
["YLR335W","NUP2",6323367,15,9,0,0,"Ran_BP1","NA","Eukaryota","Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization"]
["YLR386W","VAC14",6323418,15,14,0,0,"HEAT","NA","Eukaryota","Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p"]
["YLR392C","YLR392C",6323424,15,8,1,0,"NA","NA","Saccharomycetales","NA"]
["YLR431C","ATG23",6323463,15,6,0,0,"Glyco_transf_25","NA","Saccharomycetaceae","Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p"]
["YLR437C","YLR437C",6323469,15,7,0,0,"RNR_inhib","NA","Saccharomycetales","NA"]
["YML014W","TRM9",6323627,15,11,0,0,"Methyltransf_11~Methyltransf_12","NA","cellular organisms","tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); deletion confers resistance to zymocin"]
["YML106W","URA5",6323530,15,15,0,0,"Pribosyltran","2.4.2.10_Orotate phosphoribosyltransferase","cellular organisms","Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10"]
["YMR048W","CSM3",6323692,15,16,0,0,"Swi3","NA","Eukaryota","Protein required for accurate chromosome segregation during meiosis"]
["YMR049C","ERB1",6323693,15,4,0,0,"BOP1NT~WD40~WD40~WD40","NA","cellular organisms","Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1"]
["YMR063W","RIM9",6323708,15,25,0,0,"PalI","NA","Dikarya","Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein"]
["YMR121C","RPL15B",6323769,15,34,0,0,"Ribosomal_L15e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA"]
["YMR137C","PSO2",6323786,15,14,0,0,"DRMBL","NA","Eukaryota","Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation"]
["YMR186W","HSC82",6323840,15,18,0,0,"HATPase_c~HSP90","NA","cellular organisms","Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock"]
["YMR278W","PGM3",6323934,15,9,0,0,"PGM_PMM_I~PGM_PMM_IV","5.4.2.2_Phosphoglucomutase","cellular organisms","Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential"]
["YNL008C","ASI3",6324320,15,4,0,0,"NA","NA","Saccharomycetaceae","Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals"]
["YNL119W","NCS2",6324209,15,5,0,0,"DUF2392","NA","Eukaryota","Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"]
["YNL151C","RPC31",6324178,15,6,0,0,"NA","NA","Ascomycota","RNA polymerase III subunit C31; contains HMG-like C-terminal domain"]
["YNL263C","YIF1",6324066,15,4,0,0,"YIF1","NA","Eukaryota","Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles"]
["YNL302C","RPS19B",6324027,15,9,0,0,"Ribosomal_S19e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap"]
["YNR063W","YNR063W",6324391,15,9,1,0,"Zn_clus~Fungal_trans","NA","Ascomycota","NA"]
["YNR072W","HXT17",6324400,15,4,0,0,"Sugar_tr~MFS_1~MFS_1","NA","cellular organisms","Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose"]
["YOL054W","PSH1",6324518,15,18,1,0,"zf-C3HC4","NA","Eukaryota","Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein"]
["YOR005C","DNL4",6324578,15,13,0,0,"DNA_ligase_A_M~BRCT~BRCT","NA","cellular organisms","DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth"]
["YOR091W","TMA46",83578105,15,31,0,0,"zf-CCCH","NA","Eukaryota","Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p"]
["YOR096W","RPS7A",6324670,15,5,0,0,"Ribosomal_S7e","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins"]
["YOR182C","RPS30B",6324756,15,8,0,0,"Ribosomal_S30","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein"]
["YOR244W","ESA1",6324818,15,11,0,0,"MOZ_SAS","2.3.1.48_Histone acetyltransferase","Eukaryota","Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression"]
["YOR380W","RDR1",6324956,15,4,0,0,"Zn_clus~Fungal_trans","NA","Ascomycota","Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins"]
["YPL028W","ERG10",6325229,15,8,0,0,"Thiolase_N~ketoacyl-synt~Thiolase_C","2.3.1.9_Acetyl-CoA C-acetyltransferase","cellular organisms","Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis"]
["YPL047W","SGF11",6325210,15,16,0,0,"Sgf11","NA","Saccharomycetaceae","Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation"]
["YPL232W","SSO1",6325024,15,18,0,0,"Syntaxin~SNARE","NA","Eukaryota","Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p"]
["YPR040W","TIP41",6325297,15,14,0,0,"TIP41","NA","Eukaryota","Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway"]
["YPR041W","TIF5",6325298,15,10,0,0,"eIF-5_eIF-2B~W2","NA","cellular organisms","Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation"]
["YPR051W","MAK3",6325307,15,21,0,0,"Acetyltransf_1","2.3.1.88_Peptide alpha-N-acetyltransferase","cellular organisms","Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus"]
["YPR070W","MED1",6325327,15,19,0,0,"Med1-Trap220","NA","Saccharomycetaceae","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YBL080C","PET112",6319391,15,14,0,1,"GatB_N~GatB~GatB_Yqey","NA","cellular organisms","Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog"]
["YDR493W","AIM8",6320701,15,9,1,1,"NA","NA","Dikarya","Protein of unknown function; non-tagged protein detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media"]
["YJR051W","OSM1",6322511,15,13,0,1,"DAO~FAD_binding_2~FAD_binding_2","NA","cellular organisms","Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity"]
["YKL055C","OAR1",6322795,15,10,0,1,"adh_short~adh_short","NA","cellular organisms","Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p"]
["YPL134C","ODC1",6325123,15,10,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation"]
["YPR061C","JID1",6325318,15,29,0,1,"DnaJ","NA","Ascomycota","Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae"]
["YAL031C","GIP4",6319288,14,7,0,0,"NA","NA","Saccharomycetales","Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate"]
["YAL065C","YAL065C",6319252,14,7,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YBL007C","SLA1",6319464,14,23,0,0,"SH3_1~SH3_2~SH3_1~SH3_2~SH3_1~SH3_2~SHD1~DUF1720","NA","Fungi/Metazoa group","Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains"]
["YBL008W","HIR1",6319463,14,19,0,0,"WD40~WD40~WD40~WD40~WD40~HIRA_B~Hira","NA","cellular organisms","Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores"]
["YBL039C","URA7",6319432,14,8,0,0,"CTP_synth_N~GATase","6.3.4.2_CTP synthase","cellular organisms","Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis"]
["YBL097W","BRN1",41629672,14,7,0,0,"Barren~Barren~Barren~Barren","NA","Eukaryota","Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics"]
["YBR019C","GAL10",6319493,14,3,0,0,"Epimerase~3Beta_HSD~NAD_binding_4~Aldose_epim","NA","cellular organisms","UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers"]
["YBR053C","YBR053C",6319527,14,4,1,0,"SGL","NA","cellular organisms","NA"]
["YBR072W","HSP26",6319546,14,9,0,0,"HSP20","NA","cellular organisms","Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells"]
["YBR081C","SPT7",6319555,14,17,0,0,"Bromodomain","NA","Dikarya","Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex"]
["YBR166C","TYR1",6319643,14,3,0,0,"ApbA","1.3.1.13_Prephenate dehydrogenase (NADP(+))","cellular organisms","Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels"]
["YBR216C","YBP1",6319693,14,20,0,0,"DUF1760","NA","Saccharomycetales","Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress"]
["YBR245C","ISW1",6319722,14,27,0,0,"SNF2_N~DEAD~Helicase_C~HAND~SLIDE","NA","cellular organisms","Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation"]
["YBR246W","YBR246W",6319723,14,19,1,0,"NA","NA","Eukaryota","NA"]
["YBR280C","SAF1",37362624,14,12,0,0,"RCC1","NA","cellular organisms","F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1"]
["YCR024C-A","PMP1",7839147,14,18,0,0,"DUF1206~PMP1_2","NA","Saccharomycetaceae","Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines"]
["YCR045C","YCR045C",6319893,14,13,1,0,"Inhibitor_I9~Peptidase_S8","NA","cellular organisms","NA"]
["YCR081W","SRB8",6319923,14,10,0,0,"Med12","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression"]
["YCR106W","RDS1",6319950,14,6,0,0,"Zn_clus","NA","Saccharomycetaceae","Zinc cluster transcription factor involved in conferring resistance to cycloheximide"]
["YDL140C","RPO21",6320061,14,3,0,0,"RNA_pol_Rpb1_1~RNA_pol_Rpb1_2~RNA_pol_Rpb1_3~RNA_pol_Rpb1_4~RNA_pol_Rpb1_5~RNA_pol_Rpb1_6~RNA_pol_Rpb1_7","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime"]
["YDL159W","STE7",6320042,14,7,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.12.2_Mitogen-activated protein kinase kinase","cellular organisms","Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway"]
["YDR085C","AFR1",6320290,14,8,0,0,"NA","NA","Saccharomycetaceae","Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p"]
["YDR088C","SLU7",6320293,14,5,0,0,"zf-CCHC","NA","Eukaryota","RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain"]
["YDR153C","ENT5",6320357,14,12,0,0,"ENTH","NA","Fungi/Metazoa group","Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin"]
["YDR517W","GRH1",6320725,14,7,0,0,"GRASP55_65","NA","Eukaryota","Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes"]
["YEL007W","YEL007W",6320830,14,24,1,0,"Gti1_Pac2","NA","Dikarya","NA"]
["YEL032W","MCM3",6320803,14,2,0,0,"MCM","NA","cellular organisms","Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex"]
["YEL061C","CIN8",37362641,14,20,0,0,"Kinesin~Kinesin~5_nucleotid","NA","Eukaryota","Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation"]
["YER027C","GAL83",6320865,14,14,0,0,"AMPKBI","NA","Eukaryota","One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain"]
["YER030W","CHZ1",83578097,14,12,0,0,"CHZ","NA","Saccharomycetaceae","Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif"]
["YER032W","FIR1",37362642,14,6,0,0,"NA","NA","Saccharomycetaceae","Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate"]
["YER046W","SPO73",6320886,14,6,0,0,"NA","NA","Dikarya","Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis"]
["YER161C","SPT2",6321009,14,13,0,0,"SPT2","NA","Saccharomycetales","Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins"]
["YER164W","CHD1",6321012,14,17,0,0,"Chromo~Chromo~SNF2_N~Helicase_C~SLIDE","NA","cellular organisms","Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes"]
["YER177W","BMH1",6321025,14,27,0,0,"14-3-3","NA","Eukaryota","14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling"]
["YFL026W","STE2",14318493,14,14,0,0,"STE2","NA","Ascomycota","Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells"]
["YGL116W","CDC20",6321322,14,25,0,0,"WD40~WD40~WD40","NA","cellular organisms","Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate"]
["YGL205W","POX1",6321233,14,5,0,0,"Acyl-CoA_dh_M~ACOX","1.3.3.6_Acyl-CoA oxidase","cellular organisms","Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix"]
["YGL245W","GUS1",37362649,14,5,0,0,"tRNA-synt_1c~tRNA-synt_1c_C","6.1.1.17_Glutamate--tRNA ligase","cellular organisms","Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm"]
["YGL246C","RAI1",6321191,14,13,0,0,"RAI1","NA","Eukaryota","Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing"]
["YGR053C","YGR053C",6321490,14,2,1,0,"NA","NA","Ascomycota","NA"]
["YGR185C","TYS1",6321624,14,6,0,0,"tRNA-synt_1b","6.1.1.1_Tyrosine--tRNA ligase","cellular organisms","Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr"]
["YGR202C","PCT1",6321641,14,23,0,0,"CTP_transf_2","2.7.7.15_Choline-phosphate cytidylyltransferase","cellular organisms","Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding"]
["YHL003C","LAG1",6321784,14,12,0,0,"TRAM1~TRAM_LAG1_CLN8","2.3.1.24_Sphingosine N-acyltransferase","Eukaryota","Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p"]
["YHL008C","YHL008C",6321779,14,12,1,0,"Form_Nir_trans","NA","cellular organisms","NA"]
["YHL042W","YHL042W",6321745,14,9,1,0,"DUP","NA","Saccharomycetaceae","NA"]
["YHR068W","DYS1",6321859,14,4,0,0,"DS","2.5.1.46_Deoxyhypusine synthase","cellular organisms","Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric"]
["YHR110W","ERP5",6321902,14,6,0,0,"EMP24_GP25L","NA","Eukaryota","Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"]
["YHR116W","COX23",6321908,14,7,0,0,"CHCH","NA","Fungi/Metazoa group","Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p"]
["YIL073C","SPO22",37362662,14,41,0,0,"SPO22","NA","Ascomycota","Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis"]
["YIL142W","CCT2",6322049,14,9,0,0,"Cpn60_TCP1","NA","cellular organisms","Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"]
["YIR009W","MSL1",6322199,14,12,0,0,"RRM_1","NA","Eukaryota","U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members"]
["YIR042C","YIR042C",6322233,14,20,1,0,"Viral_cys_rich~Acetyltransf_1","NA","cellular organisms","NA"]
["YJL008C","CCT8",6322452,14,12,0,0,"Cpn60_TCP1","NA","cellular organisms","Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"]
["YJL059W","YHC3",6322402,14,2,0,0,"CLN3","NA","Eukaryota","Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)"]
["YJL179W","PFD1",6322282,14,20,0,0,"Prefoldin_2","NA","Fungi/Metazoa group","Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin"]
["YJR005W","APL1",6322464,14,17,0,0,"Adaptin_N","NA","Eukaryota","Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex"]
["YJR022W","LSM8",37362670,14,3,0,0,"LSM","NA","Eukaryota","Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA"]
["YJR063W","RPA12",6322523,14,4,0,0,"RNA_POL_M_15KD~TFIIS_C","NA","cellular organisms","RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex"]
["YJR129C","YJR129C",6322589,14,10,1,0,"Methyltransf_16~DUF2439","NA","Eukaryota","NA"]
["YKL023W","YKL023W",6322829,14,28,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YKL178C","STE3",6322671,14,12,0,0,"STE3","NA","Dikarya","Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR"]
["YKL191W","DPH2",6322657,14,16,0,0,"Diphthamide_syn~Diphthamide_syn","NA","Eukaryota","Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p"]
["YKL220C","FRE2",6322629,14,7,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","Eukaryota","Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels"]
["YKR003W","OSH6",6322855,14,4,0,0,"Oxysterol_BP","NA","Eukaryota","Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery"]
["YKR014C","YPT52",6322866,14,10,0,0,"Miro~Ras","NA","cellular organisms","GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"]
["YKR039W","GAP1",6322892,14,5,0,0,"AA_permease","NA","cellular organisms","General amino acid permease; localization to the plasma membrane is regulated by nitrogen source"]
["YKR081C","RPF2",6322934,14,4,0,0,"Brix","NA","Eukaryota","Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles"]
["YLL048C","YBT1",6322980,14,14,0,0,"ABC_membrane~ABC_tran~GSPII_E~ABC_membrane~ABC_tran~MMR_HSR1~ABC_tran","NA","cellular organisms","Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters"]
["YLR166C","SEC10",6323195,14,7,0,0,"Sec10","NA","Eukaryota","Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"]
["YLR219W","MSC3",6323248,14,8,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate"]
["YLR264W","RPS28B",6323294,14,7,0,0,"Ribosomal_S28e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein"]
["YLR266C","PDR8",6323296,14,9,0,0,"Zn_clus~Fungal_trans","NA","Saccharomycetaceae","Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon"]
["YLR288C","MEC3",6323319,14,25,0,0,"NA","NA","Saccharomycetales","DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1"]
["YLR377C","FBP1",6323409,14,5,0,0,"FBPase","3.1.3.11_Fructose-bisphosphatase","cellular organisms","Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism"]
["YLR415C","YLR415C",6323447,14,8,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR417W","VPS36",6323449,14,68,0,0,"EAP30","NA","Eukaryota","Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome"]
["YLR433C","CNA1",6323465,14,14,0,0,"Metallophos","NA","cellular organisms","Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1"]
["YML037C","YML037C",6323604,14,24,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML058W","SML1",6323582,14,8,0,0,"RNR_inhib","NA","Saccharomycetaceae","Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase"]
["YMR035W","IMP2",6323678,14,10,0,0,"Peptidase_S24","NA","cellular organisms","Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"]
["YMR078C","CTF18",6323724,14,7,0,0,"Rad17~AAA","NA","cellular organisms","Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint"]
["YMR111C","YMR111C",6323758,14,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR277W","FCP1",6323933,14,22,0,0,"NIF~NIF~BRCT","3.1.3.16_Phosphoprotein phosphatase","Eukaryota","Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)"]
["YMR306W","FKS3",6323965,14,17,0,0,"Glucan_synthase","2.4.1.34_1,3-beta-glucan synthase","Eukaryota","Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YNL032W","SIW14",6324296,14,19,0,0,"Y_phosphatase2","NA","cellular organisms","Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm"]
["YNL159C","ASI2",6324170,14,9,0,0,"NA","NA","Saccharomycetaceae","Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals"]
["YNL196C","SLZ1",6324133,14,12,1,0,"NA","NA","Saccharomyces cerevisiae","Sporulation-specific protein with a leucine zipper motif"]
["YNL286W","CUS2",6324043,14,11,0,0,"RRM_1","NA","Eukaryota","Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)"]
["YNL314W","DAL82",6324015,14,23,0,0,"NA","NA","Saccharomycetaceae","Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain"]
["YNR020C","ATP23",6324347,14,7,0,0,"Peptidase_M76","NA","Eukaryota","Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex"]
["YNR075W","COS10",6324403,14,4,0,0,"DUP~DUP","NA","Saccharomycetaceae","Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"]
["YOL014W","YOL014W",6324559,14,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YOL059W","GPD2",6324513,14,6,0,0,"NAD_Gly3P_dh_N~NAD_Gly3P_dh_C","1.1.1.8_Glycerol-3-phosphate dehydrogenase (NAD(+))","cellular organisms","NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria"]
["YOL123W","HRP1",6324449,14,4,0,0,"RRM_1~RRM_1","NA","cellular organisms","Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences"]
["YOR021C","YOR021C",6324595,14,10,1,0,"RNA_Me_trans","NA","cellular organisms","NA"]
["YOR064C","YNG1",6324638,14,15,0,0,"PHD","NA","Eukaryota","Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1"]
["YOR080W","DIA2",6324654,14,9,0,0,"F-box","NA","Saccharomycetales","Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth"]
["YOR120W","GCY1",6324694,14,7,0,0,"Aldo_ket_red","NA","cellular organisms","Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family"]
["YOR132W","VPS17",6324706,14,31,0,0,"PX","NA","Dikarya","Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation"]
["YOR185C","GSP2",6324759,14,5,0,0,"Miro~Ras~MMR_HSR1","NA","cellular organisms","GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability"]
["YOR257W","CDC31",6324831,14,9,0,0,"efhand~efhand~efhand","NA","cellular organisms","Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation"]
["YOR323C","PRO2",6324899,14,25,0,0,"NA","1.2.1.41_Glutamate-5-semialdehyde dehydrogenase","cellular organisms","Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis"]
["YOR386W","PHR1",6324962,14,4,0,0,"DNA_photolyase~DNA_photolyase~FAD_binding_7","4.1.99.3_Deoxyribodipyrimidine photo-lyase","cellular organisms","DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p"]
["YPL177C","CUP9",6325080,14,14,0,0,"NA","NA","Eukaryota","Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription"]
["YPL228W","CET1",6325028,14,5,0,0,"mRNA_triPase","3.1.3.33_Polynucleotide 5'-phosphatase","Dikarya","Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide"]
["YPR008W","HAA1",6325265,14,4,0,0,"Copper-fist","NA","Saccharomycetaceae","Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress"]
["YPR034W","ARP7",6325291,14,16,0,0,"Actin~Actin","NA","cellular organisms","Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation"]
["YPR119W","CLB2",6325376,14,29,0,0,"Cyclin_N~Cyclin_C","NA","Eukaryota","B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"]
["YBR084W","MIS1",6319558,14,16,0,1,"THF_DHG_CYH~THF_DHG_CYH_C~FTHFS","1.5.1.5_Methylenetetrahydrofolate dehydrogenase (NADP(+))|3.5.4.9_Methenyltetrahydrofolate cyclohydrolase|6.3.4.3_Formate--tetrahydrofolate ligase","cellular organisms","Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase"]
["YBR120C","CBP6",6319596,14,9,0,1,"NA","NA","Saccharomycetales","Mitochondrial translational activator of the COB mRNA; phosphorylated"]
["YGR084C","MRP13",6321521,14,7,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial ribosomal protein of the small subunit"]
["YKR016W","AIM28",6322868,14,23,1,1,"NA","NA","Dikarya","Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media"]
["YLR121C","YPS3",6323150,14,7,0,1,"Asp","NA","Eukaryota","Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"]
["YLR346C","YLR346C",6323378,14,8,1,1,"NA","NA","Saccharomyces cerevisiae","NA"]
["YNL063W","MTQ1",6324266,14,5,0,1,"MTS","NA","cellular organisms","S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene"]
["YOR215C","AIM41",6324789,14,8,1,1,"YqeY~YqeY","NA","cellular organisms","Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays altered rate of mitochondrial loss and reduced growth rate in minimal glycerol media"]
["YPL262W","FUM1",6324993,14,15,0,1,"Lyase_1~FumaraseC_C","4.2.1.2_Fumarate hydratase","cellular organisms","Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria"]
["YBR008C","FLR1",6319480,13,12,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs"]
["YBR028C","YBR028C",6319502,13,5,1,0,"Pkinase~Pkinase_Tyr~Pkinase_C","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","NA"]
["YBR058C","UBP14",37362616,13,17,0,0,"zf-UBP~UCH~UBA~UBA","NA","Eukaryota","Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T"]
["YBR132C","AGP2",6319608,13,8,0,0,"AA_permease","NA","cellular organisms","High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease"]
["YBR148W","YSW1",6319624,13,3,0,0,"NA","NA","Saccharomyces cerevisiae","Protein expressed specifically in spores"]
["YBR150C","TBS1",6319626,13,5,0,0,"Zn_clus~Fungal_trans","NA","Saccharomycetaceae","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YBR211C","AME1",6319688,13,9,0,0,"NA","NA","Saccharomycetaceae","Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance"]
["YBR229C","ROT2",6319706,13,24,0,0,"Glyco_hydro_31","NA","cellular organisms","Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations"]
["YBR236C","ABD1",6319713,13,9,0,0,"Pox_MCEL~Pox_MCEL~Methyltransf_11~Methyltransf_12~NNMT_PNMT_TEMT","2.1.1.56_mRNA (guanine-N(7)-)-methyltransferase","cellular organisms","Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA"]
["YBR252W","DUT1",6319729,13,7,0,0,"dUTPase","3.6.1.23_dUTP diphosphatase","cellular organisms","dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability"]
["YCL014W","BUD3",10383775,13,4,0,0,"NA","NA","Saccharomycetales","Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding"]
["YCL061C","MRC1",10383754,13,7,0,0,"MRC1","NA","Saccharomycetales","S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p"]
["YDL070W","BDF2",6320132,13,8,0,0,"Bromodomain~Bromodomain","NA","Eukaryota","Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p"]
["YDL091C","UBX3",6320112,13,11,0,0,"UBX","NA","Eukaryota","UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YDL116W","NUP84",6320087,13,7,0,0,"Nup84_Nup100","NA","Fungi/Metazoa group","Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis"]
["YDL143W","CCT4",6320058,13,16,0,0,"Cpn60_TCP1","NA","cellular organisms","Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"]
["YDR033W","MRH1",6320236,13,4,0,0,"NA","NA","Eukaryota","Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p"]
["YDR063W","AIM7",6320268,13,2,1,0,"NA","NA","Eukaryota","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YDR218C","SPR28",6320424,13,4,0,0,"Septin~FtsK_SpoIIIE~Dynamin_N~Septin","NA","Eukaryota","Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation"]
["YDR451C","YHP1",6320659,13,20,0,0,"Homeobox","NA","Fungi/Metazoa group","One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval"]
["YDR461W","MFA1",6320669,13,17,0,0,"DUF567","NA","Saccharomycetaceae","Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2"]
["YDR508C","GNP1",6320717,13,14,0,0,"AA_permease","NA","cellular organisms","High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids"]
["YDR510W","SMT3",6320718,13,5,0,0,"ubiquitin","NA","Eukaryota","Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics"]
["YEL011W","GLC3",6320826,13,9,0,0,"CBM_48~Alpha-amylase~Alpha-amylase_C","2.4.1.18_1,4-alpha-glucan branching enzyme","cellular organisms","Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YEL030W","ECM10",6320805,13,4,0,0,"HSP70","NA","cellular organisms","Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations"]
["YER010C","YER010C",6320847,13,5,0,0,"Methyltransf_6","NA","cellular organisms","NA"]
["YER024W","YAT2",6320862,13,6,0,0,"Carn_acyltransf~Carn_acyltransf","NA","cellular organisms","Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane"]
["YER035W","EDC2",6320873,13,10,0,0,"NA","NA","Saccharomyces cerevisiae","RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p"]
["YER057C","HMF1",6320899,13,7,0,0,"Ribonuc_L-PSP","NA","cellular organisms","Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro"]
["YER068W","MOT2",6320912,13,15,0,0,"RRM_1~PyrI_C","NA","Eukaryota","Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)"]
["YER103W","SSA4",6320950,13,8,0,0,"HSP70","NA","cellular organisms","Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation"]
["YER109C","FLO8",6320955,13,5,0,0,"LisH","NA","Saccharomyces cerevisiae","Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene"]
["YFL054C","YFL054C",14318465,13,6,1,0,"MIP","NA","cellular organisms","NA"]
["YFR031C","SMC2",14318554,13,6,0,0,"SMC_N~SMC_hinge~ABC_tran","NA","cellular organisms","Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer"]
["YGL200C","EMP24",6321238,13,3,0,0,"EMP24_GP25L","NA","Eukaryota","Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"]
["YGR047C","TFC4",6321484,13,4,0,0,"NA","NA","Eukaryota","One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102"]
["YGR087C","PDC6",6321524,13,9,0,0,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","4.1.1.1_Pyruvate decarboxylase","cellular organisms","Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation"]
["YGR177C","ATF2",6321616,13,5,0,0,"AATase","2.3.1.84_Alcohol O-acetyltransferase","Saccharomycetaceae","Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing"]
["YGR208W","SER2",6321647,13,14,0,0,"Hydrolase~Hydrolase_3","3.1.3.3_Phosphoserine phosphatase","cellular organisms","Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source"]
["YHL036W","MUP3",6321751,13,32,0,0,"NA","NA","cellular organisms","Low affinity methionine permease, similar to Mup1p"]
["YHR005C-A","MRS11",6321793,13,8,0,0,"zf-Tim10_DDP","NA","Eukaryota","Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process"]
["YHR048W","YHK8",6321838,13,6,1,0,"Sugar_tr~MFS_1","NA","cellular organisms","Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles"]
["YHR140W","YHR140W",6321933,13,14,1,0,"NA","NA","Dikarya","NA"]
["YHR204W","MNL1",6321998,13,15,0,0,"Glyco_hydro_47","NA","cellular organisms","Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides"]
["YIL041W","GVP36",6322148,13,37,0,0,"BAR_2","NA","Dikarya","Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments"]
["YIL152W","YIL152W",6322039,13,16,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YIR006C","PAN1",6322196,13,4,0,0,"DUF1720~DUF1720~DUF1720~DUF1720~efhand","NA","Dikarya","Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease"]
["YJL010C","NOP9",6322450,13,3,0,0,"PUF~PUF~PUF~PUF","NA","Eukaryota","Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats"]
["YJL087C","TRL1",6322374,13,3,0,0,"tRNA_lig_trans~tRNA_lig_kinase~tRNA_lig_CPD","6.5.1.3_RNA ligase (ATP)","cellular organisms","tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope"]
["YJR054W","YJR054W",6322514,13,22,1,0,"NA","NA","Dikarya","NA"]
["YJR064W","CCT5",6322524,13,28,0,0,"Cpn60_TCP1","NA","cellular organisms","Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"]
["YJR098C","YJR098C",6322558,13,4,1,0,"LACT~DUF900~PGAP1~Abhydrolase_1","NA","Ascomycota","NA"]
["YJR102C","VPS25",6322562,13,54,0,0,"ESCRT-II","NA","Eukaryota","Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome"]
["YJR142W","YJR142W",6322602,13,25,1,0,"NUDIX","NA","cellular organisms","NA"]
["YKL145W","RPT1",6322704,13,6,0,0,"AAA~AAA_3~AAA_5~Mg_chelatase","NA","cellular organisms","One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p"]
["YKL222C","YKL222C",6322627,13,4,0,0,"Zn_clus~Fungal_trans","NA","Ascomycota","NA"]
["YKR015C","YKR015C",6322867,13,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKR051W","YKR051W",6322904,13,5,1,0,"DUF300","NA","Eukaryota","NA"]
["YKR092C","SRP40",6322945,13,3,0,0,"SRP40_C","NA","Eukaryota","Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140"]
["YLR050C","YLR050C",6323079,13,4,1,0,"NA","NA","Eukaryota","NA"]
["YLR095C","IOC2",6323124,13,20,0,0,"PHD","NA","Saccharomycetaceae","Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif"]
["YLR345W","YLR345W",6323377,13,8,1,0,"6PF2K~PGAM","NA","cellular organisms","NA"]
["YLR360W","VPS38",6323392,13,40,0,0,"NA","NA","Saccharomycetaceae","Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity"]
["YLR399C","BDF1",6323431,13,12,0,0,"Bromodomain~Bromodomain","NA","Eukaryota","Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p"]
["YLR412W","YLR412W",6323444,13,12,0,0,"SRR1","NA","Fungi/Metazoa group","Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene"]
["YLR432W","IMD3",6323464,13,5,0,0,"IMPDH~CBS","NA","cellular organisms","Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed"]
["YML066C","SMA2",6323574,13,7,0,0,"NA","NA","Saccharomycetales","Protein of unknown function involved in the assembly of the prospore membrane during sporulation"]
["YMR032W","HOF1",6323675,13,16,0,0,"FCH~SH3_1","NA","Fungi/Metazoa group","Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p"]
["YMR037C","MSN2",6323680,13,16,0,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"]
["YMR136W","GAT2",6323785,13,8,0,0,"GATA","NA","Saccharomyces cerevisiae","Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine"]
["YMR153W","NUP53",6323802,13,6,0,0,"MPPN","NA","Saccharomycetales","Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex"]
["YMR159C","ATG16",6323811,13,11,0,0,"ATG16~ATG16","NA","Saccharomycetaceae","Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure; essential for autophagy"]
["YMR173W","DDR48",6323826,13,10,0,0,"NA","NA","cellular organisms","DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS"]
["YMR201C","RAD14",6323857,13,13,0,0,"XPA_N~XPA_C","NA","Eukaryota","Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein"]
["YMR204C","INP1",6323860,13,7,0,0,"NA","NA","Saccharomycetaceae","Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance"]
["YMR251W-A","HOR7",6323907,13,11,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor"]
["YMR322C","SNO4",6323984,13,7,1,0,"DJ-1_PfpI","NA","cellular organisms","Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Hsp33p; member of the DJ-1/ThiJ/PfpI superfamily; may have a role in pyridoxine metabolism"]
["YNL002C","RLP7",6324326,13,4,0,0,"Ribosomal_L30","NA","Eukaryota","Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs"]
["YNL108C","YNL108C",6324221,13,6,1,0,"PGAM","NA","cellular organisms","NA"]
["YNL125C","ESBP6",6324204,13,7,0,0,"MFS_1~MFS_1","NA","cellular organisms","Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane"]
["YNL147W","LSM7",158267618,13,15,0,0,"LSM","NA","Eukaryota","Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"]
["YNL172W","APC1",6324157,13,3,0,0,"NA","NA","Eukaryota","Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"]
["YNL222W","SSU72",6324107,13,7,0,0,"Ssu72","NA","Eukaryota","Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo"]
["YNR031C","SSK2",6324358,13,26,0,0,"Pkinase_Tyr~Pkinase~Pkinase","2.7.11.25_Mitogen-activated protein kinase kinase kinase","Eukaryota","MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress"]
["YNR068C","YNR068C",6324396,13,17,1,0,"Bul1_C","NA","Saccharomycetaceae","NA"]
["YOL029C","YOL029C",6324544,13,11,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR047C","STD1",6324621,13,19,0,0,"NA","NA","Saccharomycetales","Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p"]
["YOR067C","ALG8",6324641,13,25,0,0,"Alg6_Alg8","NA","Eukaryota","Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p"]
["YOR115C","TRS33",6324689,13,27,0,0,"TRAPP","NA","Eukaryota","One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic"]
["YOR155C","ISN1",6324729,13,5,0,0,"ISN1","NA","Eukaryota","Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms"]
["YOR208W","PTP2",6324782,13,3,0,0,"Y_phosphatase","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus"]
["YOR275C","RIM20",6324849,13,35,0,0,"BRO1","NA","Eukaryota","Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation"]
["YOR295W","UAF30",6324869,13,13,0,0,"DEK_C~SWIB","NA","cellular organisms","Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate"]
["YOR326W","MYO2",6324902,13,6,0,0,"Myosin_head~DIL","NA","Eukaryota","One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle"]
["YOR337W","TEA1",6324913,13,11,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein"]
["YPL023C","MET12",6325234,13,16,0,0,"MTHFR","NA","cellular organisms","Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway"]
["YPL038W","MET31",6325219,13,8,0,0,"zf-C2H2~zf-C2H2","NA","Eukaryota","Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p"]
["YPL158C","AIM44",6325099,13,10,1,0,"CDC45","NA","Saccharomycetaceae","Protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media"]
["YPL162C","YPL162C",6325095,13,5,1,0,"NA","NA","Eukaryota","NA"]
["YPL164C","MLH3",6325093,13,8,0,0,"HATPase_c~DNA_mis_repair","NA","cellular organisms","Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability"]
["YPL264C","YPL264C",6324991,13,3,1,0,"DUF6~DUF6","NA","cellular organisms","NA"]
["YPR101W","SNT309",6325358,13,12,0,0,"NA","NA","Saccharomycetaceae","Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p"]
["YPR149W","NCE102",6325407,13,9,0,0,"DUF2503","NA","Ascomycota","Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)"]
["YPR163C","TIF3",6325421,13,16,0,0,"NA","NA","Fungi/Metazoa group","Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA"]
["YPR182W","SMX3",6325440,13,2,0,0,"LSM","NA","cellular organisms","Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F"]
["YPR193C","HPA2",6325451,13,7,0,0,"Acetyltransf_1","2.3.1.48_Histone acetyltransferase","cellular organisms","Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity"]
["YBL057C","PTH2",6319414,13,9,0,1,"PTH2","3.1.1.29_Aminoacyl-tRNA hydrolase","cellular organisms","One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth"]
["YDR061W","YDR061W",6320266,13,5,1,1,"ABC_tran~ABC_tran~ABC_tran","NA","cellular organisms","NA"]
["YER014W","HEM14",6320851,13,4,0,1,"Pyr_redox_2~Thi4~DAO","1.3.3.4_Protoporphyrinogen oxidase","cellular organisms","Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX"]
["YGR165W","MRPS35",6321604,13,4,0,1,"NA","NA","Ascomycota","Mitochondrial ribosomal protein of the small subunit"]
["YIL077C","YIL077C",6322113,13,57,1,1,"DUF1689","NA","Saccharomycetaceae","NA"]
["YIL098C","FMC1",6322093,13,19,0,1,"FMC1","NA","Ascomycota","Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p"]
["YKL106W","AAT1",6322743,13,9,0,1,"Aminotran_1_2","2.6.1.1_Aspartate transaminase","cellular organisms","Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis"]
["YKR049C","FMP46",6322902,13,2,0,1,"DUF1687","NA","Saccharomycetaceae","Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YKR087C","OMA1",50593425,13,7,0,1,"Peptidase_M48","NA","cellular organisms","Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes"]
["YMR307W","GAS1",6323967,13,29,0,1,"Glyco_hydro_72~X8","NA","Eukaryota","Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor"]
["YOR201C","MRM1",6324775,13,7,0,1,"SpoU_sub_bind~SpoU_methylase","NA","cellular organisms","Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA"]
["YAL014C","SYN8",27469359,12,13,0,0,"SNARE","NA","Fungi/Metazoa group","Endosomal SNARE related to mammalian syntaxin 8"]
["YAR015W","ADE1",6319326,12,8,0,0,"SAICAR_synt","6.3.2.6_Phosphoribosylaminoimidazolesuccinocarboxamide synthase","cellular organisms","N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine"]
["YBL066C","SEF1",50593117,12,8,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Putative transcription factor, has homolog in Kluyveromyces lactis"]
["YBR006W","UGA2",6319478,12,7,0,0,"Aldedh","1.2.1.16_Succinate-semialdehyde dehydrogenase (NAD(P)(+))","cellular organisms","Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm"]
["YBR013C","YBR013C",6319487,12,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YBR021W","FUR4",6319495,12,35,0,0,"Transp_cyt_pur","NA","cellular organisms","Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues"]
["YBR030W","YBR030W",6319504,12,7,0,0,"SET","NA","Eukaryota","NA"]
["YBR074W","YBR074W",37362618,12,4,1,0,"Peptidase_M28~DUF2189","NA","cellular organisms","NA"]
["YBR098W","MMS4",27808702,12,40,0,0,"ERCC4","NA","Ascomycota","Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair"]
["YBR101C","FES1",6319577,12,9,0,0,"Fes1","NA","Eukaryota","Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum"]
["YBR131W","CCZ1",6319607,12,32,0,0,"DUF1712","NA","Saccharomycetaceae","Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway"]
["YBR193C","MED8",6319670,12,6,0,0,"NA","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YBR233W","PBP2",6319709,12,7,0,0,"KH_1~KH_1~KH_1","NA","Eukaryota","RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length"]
["YBR240C","THI2",6319717,12,6,0,0,"Zn_clus~DHC_N1","NA","Saccharomycetaceae","Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes"]
["YBR248C","HIS7",6319725,12,10,0,0,"GATase~GATase_3~Peptidase_C26~His_biosynth~His_biosynth","NA","cellular organisms","Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor"]
["YBR253W","SRB6",6319730,12,2,0,0,"NA","NA","Saccharomycetaceae","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YBR293W","VBA2",6319770,12,7,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Permease of basic amino acids in the vacuolar membrane"]
["YCR027C","RHB1",10383790,12,8,0,0,"Miro~Ras","NA","cellular organisms","Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins"]
["YCR052W","RSC6",6319900,12,10,0,0,"NA","NA","Eukaryota","Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p"]
["YCR065W","HCM1",10383801,12,8,0,0,"Fork_head","NA","Fungi/Metazoa group","Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role"]
["YCR099C","YCR099C",6319942,12,6,1,0,"NA","NA","Eukaryota","NA"]
["YDL080C","THI3",6320123,12,14,0,0,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","NA","cellular organisms","Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis"]
["YDL089W","YDL089W",6320114,12,9,0,0,"DUF2418","NA","Saccharomycetales","NA"]
["YDL141W","BPL1",6320060,12,5,0,0,"BPL_N~BPL_LipA_LipB~BPL_C","6.3.4.9_Biotin--[methylmalonyl-CoA-carboxytransferase] ligase|6.3.4.10_Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase|6.3.4.11_Biotin--[methylcrotonoyl-CoA-carboxylase] ligase|6.3.4.15_Biotin--[acetyl-CoA-carboxylase] ligase","cellular organisms","Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation"]
["YDL184C","RPL41A",6320017,12,4,0,0,"Ribosomal_L41","NA","Saccharomyces cerevisiae","Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable"]
["YDL218W","YDL218W",6319983,12,7,1,0,"DUF2503~DUF2503","NA","Saccharomycetaceae","NA"]
["YDR069C","DOA4",6320274,12,14,0,0,"Rhodanese~UCH","3.1.2.15_Ubiquitin thiolesterase","cellular organisms","Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole"]
["YDR110W","FOB1",6320315,12,6,0,0,"NA","NA","Saccharomycetaceae","Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases"]
["YDR137W","RGP1",6320340,12,17,0,0,"Rgp1","NA","Ascomycota","Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p"]
["YDR150W","NUM1",6320353,12,8,0,0,"PH","NA","Saccharomycetales","Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex"]
["YDR179C","CSN9",6320384,12,3,0,0,"NA","NA","Saccharomycetaceae","Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"]
["YDR207C","UME6",6320413,12,23,0,0,"Zn_clus","NA","Saccharomycetaceae","Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p"]
["YDR292C","SRP101",6320498,12,6,0,0,"SRX~SRP-alpha_N~SRP54~SRP54~SRP54","NA","cellular organisms","Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p"]
["YDR323C","PEP7",6320530,12,32,0,0,"FYVE","NA","Fungi/Metazoa group","Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance"]
["YDR329C","PEX3",6320536,12,14,0,0,"Peroxin-3","NA","Eukaryota","Peroxisomal membrane protein (PMP) required required for the proper localization and stability of PMPs; interacts with Pex19p"]
["YDR397C","NCB2",6320605,12,3,0,0,"CBFD_NFYB_HMF","NA","Eukaryota","Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta"]
["YDR425W","SNX41",6320633,12,10,0,0,"PX","NA","Fungi/Metazoa group","Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p"]
["YDR485C","VPS72",37362638,12,9,0,0,"YL1~YL1_C","NA","Dikarya","Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting"]
["YEL019C","MMS21",6320817,12,5,0,0,"NA","NA","Eukaryota","SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination"]
["YER016W","BIM1",6320853,12,24,0,0,"CH~EB1","NA","Eukaryota","Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally"]
["YFL056C","AAD6",14318463,12,16,0,0,"Aldo_ket_red","NA","cellular organisms","Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response"]
["YFR007W","YFH7",14318529,12,16,0,0,"AAA~AAA_5~Mg_chelatase","NA","cellular organisms","Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YFR034C","PHO4",14318559,12,16,0,0,"HLH","NA","Saccharomycetaceae","Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability"]
["YGL126W","SCS3",6321312,12,3,0,0,"Scs3p","NA","Ascomycota","Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol"]
["YGL160W","AIM14",6321278,12,12,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","Eukaryota","Putative protein of unknown function; similar to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes, null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YGL259W","YPS5",6321178,12,6,1,0,"Asp","NA","Saccharomyces cerevisiae","Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p"]
["YGR052W","FMP48",6321489,12,11,1,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation"]
["YGR067C","YGR067C",6321504,12,7,1,0,"zf-C2H2","NA","Saccharomycetaceae","NA"]
["YGR133W","PEX4",6321572,12,16,0,0,"UQ_con","6.3.2.19_Ubiquitin--protein ligase","Eukaryota","Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis"]
["YGR157W","CHO2",6321596,12,19,0,0,"NA","2.1.1.17_Phosphatidylethanolamine N-methyltransferase","Eukaryota","Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis"]
["YGR178C","PBP1",6321617,12,21,0,0,"LsmAD","NA","Eukaryota","Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay"]
["YGR214W","RPS0A",6321653,12,6,0,0,"Ribosomal_S2","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"]
["YGR273C","YGR273C",6321712,12,7,1,0,"DUF2406","NA","Ascomycota","NA"]
["YHL006C","SHU1",41629684,12,23,0,0,"NA","NA","Saccharomycetaceae","Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p"]
["YHL011C","PRS3",6321776,12,20,0,0,"Pribosyltran","2.7.6.1_Ribose-phosphate diphosphokinase","cellular organisms","5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"]
["YHR010W","RPL27A",6321798,12,9,0,0,"KOW~Ribosomal_L27e","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein"]
["YHR034C","PIH1",6321823,12,4,0,0,"PIH1","NA","Eukaryota","Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)"]
["YHR082C","KSP1",6321874,12,8,0,0,"Pkinase~Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation"]
["YIL040W","APQ12",6322149,12,6,0,0,"NA","NA","Saccharomycetaceae","Protein involved in nucleocytoplasmic transport of mRNA"]
["YIL102C","YIL102C",6322089,12,10,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YIL132C","CSM2",6322059,12,19,0,0,"NA","NA","Saccharomycetaceae","Protein required for accurate chromosome segregation during meiosis"]
["YJL049W","YJL049W",6322412,12,8,1,0,"Snf7","NA","Dikarya","NA"]
["YJL079C","PRY1",6322382,12,8,0,0,"SCP","NA","cellular organisms","Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins"]
["YJL106W","IME2",6322355,12,7,0,0,"Pkinase~Pkinase_Tyr~Pox_ser-thr_kin","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p"]
["YJL160C","YJL160C",42742254,12,6,1,0,"PIR~PIR~PIR~PIR","NA","Ascomycota","NA"]
["YJL168C","SET2",6322293,12,20,0,0,"SET~SRI","2.1.1.43_Histone-lysine N-methyltransferase","Eukaryota","Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p"]
["YJR034W","PET191",6322494,12,8,0,0,"Pet191_N","NA","Eukaryota","Protein required for assembly of cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YJR074W","MOG1",6322534,12,10,0,0,"Mog1~Mog1","NA","Eukaryota","Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p"]
["YKL012W","PRP40",6322840,12,3,0,0,"WW~WW~FF~FF~FF~FF","NA","Eukaryota","U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex"]
["YKR013W","PRY2",6322864,12,26,0,0,"SCP","NA","cellular organisms","Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins"]
["YKR029C","SET3",6322881,12,27,0,0,"PHD~SET","NA","Dikarya","Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains"]
["YKR048C","NAP1",6322901,12,10,0,0,"NAP","NA","Eukaryota","Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2"]
["YLL014W","YLL014W",6323015,12,7,1,0,"NA","NA","Ascomycota","NA"]
["YLL015W","BPT1",6323014,12,13,0,0,"ABC_membrane~ABC_tran~MMR_HSR1~Dynamin_N~ABC_membrane~ABC_tran","NA","cellular organisms","ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p"]
["YLL032C","YLL032C",6322996,12,27,0,0,"KH_1","NA","Fungi","NA"]
["YLR027C","AAT2",37362677,12,31,0,0,"Aminotran_1_2","2.6.1.1_Aspartate transaminase","cellular organisms","Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells"]
["YLR063W","YLR063W",6323092,12,7,1,0,"NA","NA","Dikarya","NA"]
["YLR231C","BNA5",6323261,12,8,0,0,"NA","3.7.1.3_Kynureninase","cellular organisms","Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"]
["YLR287C-A","RPS30A",6323318,12,10,0,0,"Ribosomal_S30","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein"]
["YLR318W","EST2",6323350,12,12,0,0,"NA","2.7.7.49_RNA-directed DNA polymerase","Eukaryota","Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia"]
["YLR381W","CTF3",6323413,12,7,0,0,"NA","NA","Saccharomycetaceae","Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules"]
["YML052W","SUR7",6323589,12,10,0,0,"SUR7","NA","Ascomycota","Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants"]
["YML065W","ORC1",6323575,12,7,0,0,"BAH~AAA","NA","cellular organisms","Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity"]
["YMR047C","NUP116",6323691,12,6,0,0,"Nucleoporin2","NA","Eukaryota","Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p"]
["YMR120C","ADE17",6323768,12,6,0,0,"MGS~AICARFT_IMPCHas","NA","cellular organisms","Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine"]
["YMR148W","YMR148W",6323797,12,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR154C","RIM13",6323804,12,31,0,0,"NA","NA","Eukaryota","Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB"]
["YMR161W","HLJ1",6323813,12,20,0,0,"DnaJ","NA","cellular organisms","Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ"]
["YNL011C","YNL011C",6324317,12,6,1,0,"UPF0052","NA","cellular organisms","NA"]
["YNL199C","GCR2",6324130,12,7,0,0,"NA","NA","Saccharomycetaceae","Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p"]
["YNL229C","URE2",6324100,12,30,0,0,"GST_N~GST_C","NA","cellular organisms","Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion"]
["YNR061C","YNR061C",6324389,12,8,1,0,"DUF2503~PMEI","NA","Saccharomycetales","NA"]
["YNR065C","YNR065C",6324393,12,4,1,0,"NA","NA","Eukaryota","NA"]
["YOL075C","YOL075C",6324498,12,8,1,0,"ABC_tran~Pox_A32~ABC_tran~ABC2_membrane~ABC2_membrane~DUF258~ABC_tran~ABC2_membrane","NA","Saccharomyces cerevisiae","NA"]
["YOR001W","RRP6",6324574,12,14,0,0,"PMC2NT~3_5_exonuc~HRDC","NA","cellular organisms","Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus"]
["YOR020C","HSP10",6324594,12,11,0,0,"Cpn10","NA","cellular organisms","Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES"]
["YOR089C","VPS21",6324663,12,31,0,0,"Miro~Ras","NA","cellular organisms","GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog"]
["YOR157C","PUP1",6324731,12,8,0,0,"Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Endopeptidase with trypsin-like activity that cleaves after basic residues; beta 2 subunit of 20S proteasome, synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z"]
["YOR167C","RPS28A",6324741,12,9,0,0,"Ribosomal_S28e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein"]
["YOR171C","LCB4",6324745,12,6,0,0,"DAGK_cat","2.7.1.91_Sphinganine kinase","cellular organisms","Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes"]
["YOR293W","RPS10A",6324867,12,4,0,0,"S10_plectin","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10"]
["YOR306C","MCH5",6324882,12,15,0,0,"Sugar_tr~MFS_1~MFS_1~MFS_1","NA","cellular organisms","Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport"]
["YOR360C","PDE2",6324936,12,25,0,0,"PDEase_I","3.1.4.17_3',5'-cyclic-nucleotide phosphodiesterase","Eukaryota","High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon"]
["YOR378W","YOR378W",6324954,12,5,1,0,"MFS_1","NA","cellular organisms","NA"]
["YOR381W","FRE3",6324957,12,7,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","cellular organisms","Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels"]
["YPL002C","SNF8",6325255,12,70,0,0,"EAP30","NA","Eukaryota","Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression"]
["YPL004C","LSP1",6325253,12,2,0,0,"DDOST_48kD","NA","Dikarya","Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways"]
["YPL119C","DBP1",6325138,12,8,0,0,"DEAD~Helicase_C","NA","cellular organisms","Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs"]
["YPL138C","SPP1",6325119,12,24,0,0,"PHD","NA","Fungi/Metazoa group","Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein"]
["YPL193W","RSA1",6325063,12,12,0,0,"NUFIP1","NA","Saccharomycetaceae","Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly"]
["YPL225W","YPL225W",6325031,12,13,0,0,"DUF757","NA","Eukaryota","NA"]
["YPL257W","YPL257W",6324998,12,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YPR078C","YPR078C",6325335,12,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YPR162C","ORC4",6325420,12,3,0,0,"NA","NA","Eukaryota","Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"]
["YGR220C","MRPL9",6321659,12,16,0,1,"Ribosomal_L3","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YHR155W","YSP1",6321949,12,23,0,1,"PH","NA","Ascomycota","Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone"]
["YIL157C","COA1",6322034,12,13,0,1,"DUF1783","NA","Dikarya","Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly"]
["YKR052C","MRS4",6322905,12,27,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron"]
["YLR289W","GUF1",6323320,12,16,0,1,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~EFG_C~LepA_C","NA","cellular organisms","Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans"]
["YLR290C","YLR290C",6323321,12,10,1,1,"Epimerase","NA","cellular organisms","NA"]
["YNL252C","MRPL17",6324077,12,13,0,1,"NA","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit"]
["YOR004W","UTP23",6324577,12,3,0,1,"Fcf1","NA","Eukaryota","Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function"]
["YOR108W","LEU9",6324682,12,6,0,1,"HMGL-like~LeuA_dimer","2.3.3.13_2-isopropylmalate synthase","cellular organisms","Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant"]
["YPL097W","MSY1",6325160,12,17,0,1,"tRNA-synt_1b","6.1.1.1_Tyrosine--tRNA ligase","cellular organisms","Mitochondrial tyrosyl-tRNA synthetase"]
["YPR002W","PDH1",6325258,12,4,0,1,"MmgE_PrpD","4.2.1.79_2-methylcitrate dehydratase","cellular organisms","Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate"]
["YAL036C","RBG1",6319281,11,11,0,0,"MMR_HSR1~TGS","NA","cellular organisms","Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p"]
["YBL018C","POP8",6319453,11,4,0,0,"NA","3.1.26.5_Ribonuclease P","Ascomycota","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"]
["YBL074C","AAR2",6319398,11,2,0,0,"AAR2","NA","Eukaryota","Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron"]
["YBL082C","ALG3",6319389,11,19,0,0,"ALG3","2.4.1.130_Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase","Eukaryota","Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins"]
["YBR022W","POA1",6319496,11,8,0,0,"Macro","NA","cellular organisms","Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing"]
["YBR065C","ECM2",6319539,11,7,0,0,"NA","NA","Eukaryota","Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p"]
["YBR093C","PHO5",6319569,11,8,0,0,"Acid_phosphat_A~PGAM","3.1.3.2_Acid phosphatase","Eukaryota","Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2"]
["YBR102C","EXO84",6319578,11,18,0,0,"Vps51","NA","Fungi/Metazoa group","Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis"]
["YBR103W","SIF2",6319579,11,31,0,0,"LisH~WD40~WD40~WD40","NA","cellular organisms","WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus"]
["YBR189W","RPS9B",6319666,11,17,0,0,"Ribosomal_S4~S4","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins"]
["YCL036W","GFD2",6319813,11,12,0,0,"NA","NA","Dikarya","Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation"]
["YDL081C","RPP1A",6320122,11,7,0,0,"Ribosomal_60s","NA","Eukaryota","Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component"]
["YDL130W","RPP1B",6320073,11,5,0,0,"Ribosomal_60s","NA","Eukaryota","Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component"]
["YDL167C","NRP1",6320034,11,18,0,0,"RRM_1~zf-RanBP~zf-RanBP","NA","Ascomycota","Protein of unknown function, rich in asparagine residues"]
["YDL171C","GLT1",6320030,11,6,0,0,"GATase_2~Glu_syn_central~Glu_synthase~GXGXG~DAO~Pyr_redox_2~Amino_oxidase","1.4.1.14_Glutamate synthase (NADH)","cellular organisms","NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source"]
["YDL240W","LRG1",6319961,11,5,0,0,"LIM~LIM~LIM~RhoGAP","NA","Fungi/Metazoa group","Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis"]
["YDL243C","AAD4",6319958,11,8,0,0,"Aldo_ket_red","NA","cellular organisms","Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response"]
["YDR107C","TMN2",6320312,11,5,0,0,"EMP70","NA","Eukaryota","Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments"]
["YDR108W","GSG1",6320313,11,41,0,0,"NA","NA","Ascomycota","Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication"]
["YDR138W","HPR1",6320342,11,18,0,0,"HRP1","NA","Saccharomycetaceae","Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p"]
["YDR146C","SWI5",6320350,11,12,0,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase"]
["YDR158W","HOM2",6320362,11,10,0,0,"Semialdhyde_dh~Semialdhyde_dhC","1.2.1.11_Aspartate-semialdehyde dehydrogenase","cellular organisms","Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"]
["YDR198C","RKM2",6320404,11,3,0,0,"NA","NA","Fungi/Metazoa group","Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp"]
["YDR251W","PAM1",6320457,11,7,0,0,"NA","NA","Ascomycota","Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype"]
["YDR334W","SWR1",6320541,11,40,0,0,"HSA~SNF2_N~Helicase_C","NA","cellular organisms","Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"]
["YDR370C","YDR370C",6320578,11,11,1,0,"NA","NA","Saccharomycetales","NA"]
["YDR407C","TRS120",6320615,11,6,0,0,"Trs120","NA","Fungi/Metazoa group","One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic"]
["YDR520C","YDR520C",6320729,11,5,1,0,"Zn_clus","NA","Saccharomycetaceae","Putative transcription factor; contains the (Zn(II)2Cys6 motif; GFP-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine; similar to the S. Kluyveri URC2 uracil catabolism gene"]
["YEL049W","PAU2",6320786,11,9,0,0,"SRP1_TIP1","NA","Saccharomycetaceae","Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"]
["YEL056W","HAT2",6320779,11,6,0,0,"WD40~WD40","2.3.1.48_Histone acetyltransferase","cellular organisms","Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing"]
["YER019W","ISC1",6320856,11,14,0,0,"Exo_endo_phos","NA","cellular organisms","Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance"]
["YER066W","YER066W",6320909,11,6,1,0,"WD40~WD40","NA","cellular organisms","NA"]
["YER091C","MET6",6320936,11,6,0,0,"Meth_synt_1~Meth_synt_2~Meth_synt_1","2.1.1.14_5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase","cellular organisms","Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs"]
["YER143W","DDI1",6320991,11,4,0,0,"Asp_protease~RVP~UBA","NA","Eukaryota","DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control"]
["YER155C","BEM2",6321003,11,15,0,0,"RasGEF~RasGEF_N~PH~RhoGAP","NA","Saccharomycetales","Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence"]
["YFL034W","YFL034W",14318485,11,31,1,0,"DUF726","NA","cellular organisms","NA"]
["YFL038C","YPT1",14318480,11,3,0,0,"Miro~Ras","NA","cellular organisms","Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)"]
["YFR006W","YFR006W",14318528,11,5,1,0,"AMP_N~Peptidase_M24","NA","cellular organisms","NA"]
["YFR039C","YFR039C",14318564,11,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGL045W","RIM8",27808707,11,35,0,0,"Arrestin_N~Arrestin_C","NA","Ascomycota","Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF"]
["YGL063W","PUS2",6321375,11,3,0,0,"PseudoU_synth_1~PseudoU_synth_1","NA","cellular organisms","Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification"]
["YGL146C","YGL146C",6321292,11,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGL222C","EDC1",6321216,11,5,0,0,"NA","NA","Saccharomycetaceae","RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p"]
["YGL253W","HXK2",6321184,11,27,0,0,"Hexokinase_1~Hexokinase_2","2.7.1.1_Hexokinase","cellular organisms","Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene"]
["YGR016W","YGR016W",6321453,11,5,1,0,"NA","NA","Saccharomycetales","NA"]
["YGR145W","ENP2",6321584,11,7,0,0,"NUC153","NA","Eukaryota","Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p"]
["YGR239C","PEX21",6321678,11,6,0,0,"NA","NA","Saccharomycetaceae","Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p"]
["YGR251W","YGR251W",6321690,11,3,1,0,"NA","NA","Saccharomycetales","NA"]
["YHL017W","YHL017W",6321770,11,13,1,0,"Lung_7-TM_R","NA","Eukaryota","NA"]
["YHR020W","YHR020W",6321808,11,11,0,0,"tRNA-synt_2b~HGTP_anticodon~ProRS-C_1","6.1.1.15_Proline--tRNA ligase","cellular organisms","NA"]
["YHR058C","MED6",6321849,11,13,0,0,"MED6","NA","Eukaryota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YHR108W","GGA2",6321900,11,41,0,0,"VHS~Alpha_adaptinC2","NA","Eukaryota","Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi"]
["YHR177W","YHR177W",6321971,11,11,1,0,"Gti1_Pac2","NA","Dikarya","NA"]
["YHR179W","OYE2",6321973,11,22,0,0,"Oxidored_FMN","1.6.99.1_NADPH dehydrogenase","cellular organisms","Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism"]
["YHR203C","RPS4B",6321997,11,8,0,0,"RS4NT~S4~Ribosomal_S4e~KOW","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein"]
["YIL049W","DFG10",6322140,11,14,0,0,"Steroid_dh~UPF0239","NA","Eukaryota","Protein of unknown function, involved in filamentous growth"]
["YIL096C","YIL096C",6322095,11,16,1,0,"DUF2431","NA","Eukaryota","NA"]
["YIL107C","PFK26",6322084,11,22,0,0,"6PF2K~PGAM","2.7.1.105_6-phosphofructo-2-kinase","cellular organisms","6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A"]
["YIR004W","DJP1",6322194,11,17,0,0,"DnaJ","NA","cellular organisms","Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ"]
["YIR027C","DAL1",6322218,11,3,0,0,"Amidohydro_1~Amidohydro_3","3.5.2.5_Allantoinase","cellular organisms","Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression"]
["YIR035C","YIR035C",6322226,11,9,1,0,"adh_short~Epimerase~TrkA_N","NA","cellular organisms","NA"]
["YIR037W","HYR1",6322228,11,18,0,0,"GSHPx~Redoxin","1.11.1.15_Peroxiredoxin","cellular organisms","Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor"]
["YJL098W","SAP185",6322363,11,9,0,0,"SAPS","NA","Eukaryota","Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p"]
["YJL128C","PBS2",6322333,11,29,0,0,"Pkinase~Pkinase_Tyr","2.7.12.2_Mitogen-activated protein kinase kinase","cellular organisms","MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition"]
["YJR013W","GPI14",42742257,11,8,0,0,"Mannosyl_trans","NA","Eukaryota","Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M"]
["YJR031C","GEA1",6322491,11,13,0,0,"Sec7","NA","Eukaryota","Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p"]
["YJR033C","RAV1",6322493,11,33,0,0,"NA","NA","Eukaryota","Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate"]
["YJR053W","BFA1",6322513,11,10,0,0,"NA","NA","Saccharomycetales","Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis"]
["YKL064W","MNR2",6322786,11,15,0,0,"SR-25~CorA~CorA","NA","Eukaryota","Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations"]
["YKL074C","MUD2",6322776,11,7,0,0,"RRM_1","NA","Eukaryota","Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65"]
["YKL089W","MIF2",6322761,11,6,0,0,"NA","NA","Dikarya","Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p"]
["YKL132C","RMA1",6322718,11,10,0,0,"NA","6.3.2.17_Tetrahydrofolate synthase","cellular organisms","Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YKL141W","SDH3",6322708,11,5,0,0,"Sdh_cyt","NA","cellular organisms","Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone"]
["YKL148C","SDH1",6322701,11,11,0,0,"Thi4~FAD_binding_2~Pyr_redox_2~Succ_DH_flav_C","1.3.5.1_Succinate dehydrogenase (ubiquinone)","cellular organisms","Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone"]
["YKL181W","PRS1",6322667,11,4,0,0,"Pribosyltran","2.7.6.1_Ribose-phosphate diphosphokinase","cellular organisms","5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"]
["YKL215C","YKL215C",6322634,11,7,1,0,"Hydant_A_N~Hydantoinase_A~Hydantoinase_B","NA","cellular organisms","NA"]
["YKR005C","YKR005C",157285914,11,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLL036C","PRP19",6322992,11,6,0,0,"Prp19","NA","Eukaryota","Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases"]
["YLR016C","PML1",6323044,11,7,0,0,"FHA","NA","Eukaryota","Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p"]
["YLR017W","MEU1",6323045,11,7,0,0,"PNP_UDP_1","NA","cellular organisms","Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression"]
["YLR025W","SNF7",6323053,11,80,0,0,"Snf7","NA","Eukaryota","One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes"]
["YLR033W","RSC58",6323061,11,15,0,0,"Bromodomain","NA","Saccharomycetales","Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit"]
["YLR047C","FRE8",6323076,11,12,0,0,"Ferric_reduct","1.16.1.7_Ferric-chelate reductase","Dikarya","Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p"]
["YLR064W","YLR064W",6323093,11,14,1,0,"NA","NA","Dikarya","NA"]
["YLR089C","ALT1",6323118,11,13,1,0,"Aminotran_1_2~Aminotran_1_2","2.6.1.2_Alanine transaminase","cellular organisms","Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YLR145W","RMP1",6323174,11,6,0,0,"NA","NA","Ascomycota","Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P"]
["YLR178C","TFS1",6323207,11,7,0,0,"PBP","NA","cellular organisms","Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway"]
["YLR354C","TAL1",6323386,11,9,0,0,"Transaldolase","2.2.1.2_Transaldolase","cellular organisms","Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate"]
["YLR397C","AFG2",6323429,11,4,0,0,"AAA~AAA_5~Mg_chelatase~Rad17~AAA","NA","cellular organisms","ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs"]
["YML073C","RPL6A",6323567,11,5,0,0,"Ribosomal_L6e","NA","cellular organisms","N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA"]
["YML088W","UFO1",6323551,11,9,0,0,"F-box~PRANC~UIM","NA","Saccharomycetales","F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation"]
["YMR077C","VPS20",6323723,11,58,0,0,"Snf7","NA","Eukaryota","Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes"]
["YMR096W","SNZ1",6323743,11,6,0,0,"SOR_SNZ~ThiG","NA","cellular organisms","Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins"]
["YMR106C","YKU80",6323753,11,11,0,0,"Ku_N~Ku~Ku_C","NA","Eukaryota","Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair"]
["YMR123W","PKR1",6323771,11,17,0,0,"Pkr1","NA","Dikarya","V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V<sub>0</sub>); overproduction confers resistance to Pichia farinosa killer toxin"]
["YMR146C","TIF34",6323795,11,2,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation"]
["YMR155W","YMR155W",6323805,11,9,1,0,"NA","NA","Eukaryota","NA"]
["YMR190C","SGS1",6323844,11,17,0,0,"DEAD~Helicase_C~RQC","NA","cellular organisms","Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes"]
["YMR297W","PRC1",6323955,11,14,0,0,"Carbpep_Y_N~Peptidase_S10","3.4.16.5_Carboxypeptidase C","cellular organisms","Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family"]
["YNL050C","YNL050C",6324278,11,4,1,0,"DUF2011","NA","Saccharomycetales","NA"]
["YNL056W","OCA2",6324272,11,28,0,0,"Y_phosphatase2","NA","cellular organisms","Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene"]
["YNL059C","ARP5",6324269,11,8,0,0,"Actin~Actin~Actin","NA","cellular organisms","Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"]
["YNL128W","TEP1",6324201,11,10,0,0,"DSPc","3.1.3.67_Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase","Eukaryota","Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation"]
["YNL161W","CBK1",6324168,11,10,0,0,"Pkinase~Pkinase_Tyr~Pox_ser-thr_kin~Pkinase~Pkinase_C","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation"]
["YNL204C","SPS18",6324125,11,13,0,0,"ArfGap","NA","Eukaryota","Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation"]
["YNL247W","YNL247W",6324082,11,7,0,0,"tRNA-synt_1e~tRNA-synt_1g~tRNA-synt_1","6.1.1.16_Cysteine--tRNA ligase","cellular organisms","NA"]
["YNL251C","NRD1",6324078,11,9,0,0,"RRM_1","NA","Fungi/Metazoa group","RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs"]
["YNL294C","RIM21",6324035,11,36,0,0,"PalH","NA","Ascomycota","Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH"]
["YNL295W","YNL295W",6324034,11,21,1,0,"Pet20","NA","Saccharomycetaceae","NA"]
["YNL299W","TRF5",81360384,11,15,0,0,"NTP_transf_2~PAP_assoc","NA","cellular organisms","Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase"]
["YOL031C","SIL1",6324542,11,6,0,0,"NA","NA","Ascomycota","Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein"]
["YOL088C","MPD2",6324484,11,19,0,0,"Thioredoxin","5.3.4.1_Protein disulfide-isomerase","Eukaryota","Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p"]
["YOL100W","PKH2",6324472,11,14,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p"]
["YOL103W","ITR2",37362691,11,9,0,0,"Sugar_tr~MFS_1~TRI12~MFS_1","NA","cellular organisms","Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively"]
["YOR154W","SLP1",6324728,11,4,1,0,"Sad1_UNC","NA","Eukaryota","Integral membrane protein of unknown function; member of the SUN-like family of proteins"]
["YOR164C","YOR164C",6324738,11,27,0,0,"DUF410","NA","Eukaryota","NA"]
["YOR165W","SEY1",6324739,11,18,0,0,"Dynamin_N~RHD3","NA","Eukaryota","Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective)"]
["YOR292C","YOR292C",6324866,11,16,1,0,"Mpv17_PMP22","NA","Eukaryota","NA"]
["YOR375C","GDH1",6324951,11,5,0,0,"ELFV_dehydrog_N~ELFV_dehydrog","1.4.1.4_Glutamate dehydrogenase (NADP(+))","cellular organisms","NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources"]
["YPL050C","MNN9",6325207,11,11,0,0,"Anp1","NA","Eukaryota","Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation"]
["YPL051W","ARL3",6325206,11,38,0,0,"Arf~Miro~GTP_EFTU","NA","cellular organisms","GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor"]
["YPL106C","SSE1",6325151,11,14,0,0,"HSP70","NA","cellular organisms","ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm"]
["YPL152W","RRD2",6325105,11,23,0,0,"PTPA","NA","Eukaryota","Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex"]
["YPL180W","TCO89",6325077,11,13,0,0,"TCO89","NA","Saccharomycetaceae","Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin"]
["YPL268W","PLC1",6324987,11,9,0,0,"efhand~PI-PLC-X~PI-PLC-Y","3.1.4.11_Phosphoinositide phospholipase C","Eukaryota","Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes"]
["YPR005C","HAL1",6325262,11,4,0,0,"NA","NA","Saccharomyces cerevisiae","Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p"]
["YPR015C","YPR015C",6325272,11,4,1,0,"zf-C2H2~zf-C2H2","NA","Eukaryota","NA"]
["YPR028W","YOP1",6325285,11,4,0,0,"TB2_DP1_HVA22","NA","Eukaryota","Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells"]
["YPR057W","BRR1",6325314,11,7,0,0,"NA","NA","Saccharomycetaceae","snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed"]
["YPR154W","PIN3",6325412,11,13,0,0,"SH3_1~SH3_2","NA","Eukaryota","Protein that induces appearance of [PIN+] prion when overproduced"]
["YBR221C","PDB1",6319698,11,6,0,1,"Transket_pyr~Transketolase_C","1.2.4.1_Pyruvate dehydrogenase (acetyl-transferring)","cellular organisms","E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria"]
["YCL044C","MGR1",6319805,11,7,0,1,"Mgr1","NA","Saccharomycetaceae","Subunit, with Yme1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; required for growth of cells lacking the mitochondrial genome"]
["YDL067C","COX9",6320136,11,19,0,1,"COX9","1.9.3.1_Cytochrome-c oxidase","Dikarya","Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"]
["YDR185C","YDR185C",6320391,11,6,1,1,"PRELI","NA","Eukaryota","NA"]
["YDR337W","MRPS28",6320544,11,8,0,1,"Ribosomal_S15","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YGR147C","NAT2",6321586,11,9,0,1,"NA","2.3.1.88_Peptide alpha-N-acetyltransferase","Dikarya","Protein with an apparent role in acetylation of N-terminal methionine residues"]
["YIL070C","MAM33",6322119,11,5,0,1,"MAM33","NA","Eukaryota","Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R"]
["YJL131C","AIM23",6322330,11,8,1,1,"NA","NA","Saccharomycetales","Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays increased frequency of mitochondrial genome loss (petite formation)"]
["YKL114C","APN1",6322735,11,10,0,1,"AP_endonuc_2","4.2.99.18_DNA-(apurinic or apyrimidinic site) lyase","cellular organisms","Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine"]
["YMR098C","LRC4",6323745,11,4,0,1,"DUF143","NA","Ascomycota","Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YNL315C","ATP11",6324014,11,10,0,1,"ATP11","NA","Eukaryota","Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase"]
["YOR350C","MNE1",6324926,11,8,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase"]
["YAL015C","NTG1",6319304,10,21,0,0,"HhH-GPD~HHH","NA","cellular organisms","DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion"]
["YAL017W","PSK1",6319302,10,4,0,0,"Pkinase~APH","2.7.11.1_Non-specific serine/threonine protein kinase","Fungi/Metazoa group","One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status"]
["YAL054C","ACS1",6319264,10,11,0,0,"AMP-binding","6.2.1.1_Acetate--CoA ligase","cellular organisms","Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions"]
["YBL010C","YBL010C",6319461,10,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBR164C","ARL1",6319641,10,40,0,0,"Arf~DLIC~SRPRB~Miro","NA","cellular organisms","Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor"]
["YBR188C","NTC20",6319665,10,8,0,0,"NA","NA","Saccharomycetaceae","Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing"]
["YBR203W","COS111",6319680,10,6,0,0,"NA","NA","Saccharomycetales","Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YBR220C","YBR220C",6319697,10,8,1,0,"NA","NA","cellular organisms","NA"]
["YBR222C","PCS60",6319699,10,8,0,0,"AMP-binding","NA","cellular organisms","Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase"]
["YDL001W","RMD1",6320203,10,18,0,0,"DUF155","NA","cellular organisms","Cytoplasmic protein required for sporulation"]
["YDL006W","PTC1",6320198,10,22,0,0,"PP2C","NA","cellular organisms","Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation"]
["YDL064W","UBC9",6320139,10,5,0,0,"UQ_con","NA","Eukaryota","SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)"]
["YDL106C","PHO2",6320097,10,13,0,0,"Homeobox","NA","Fungi/Metazoa group","Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p"]
["YDL230W","PTP1",6319971,10,3,0,0,"Y_phosphatase~Y_phosphatase~DSPc","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria"]
["YDL232W","OST4",6319969,10,5,0,0,"Ost4","2.4.1.119_Dolichyl-diphosphooligosaccharide--protein glycotransferase","Saccharomycetaceae","Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex"]
["YDR017C","KCS1",6320220,10,9,0,0,"Hepar_II_III~IPK","2.7.4.21_Inositol-hexakisphosphate kinase","Eukaryota","Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance"]
["YDR055W","PST1",6320260,10,2,0,0,"Recep_L_domain","NA","cellular organisms","Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1"]
["YDR066C","RTR2",6320271,10,3,1,0,"RPAP2_Rtr1","NA","Saccharomycetaceae","Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene"]
["YDR078C","SHU2",6320283,10,10,0,0,"NA","NA","Saccharomycetaceae","Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p"]
["YDR084C","TVP23",6320289,10,18,0,0,"DUF846","NA","Eukaryota","Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YDR109C","YDR109C",6320314,10,3,1,0,"FGGY_N~FGGY_C","NA","cellular organisms","NA"]
["YDR128W","YDR128W",6320333,10,7,0,0,"WD40~WD40","NA","cellular organisms","Putative protein of unknown function; YDR128W is synthetically sick with cdc13-1"]
["YDR151C","CTH1",6320355,10,8,0,0,"zf-CCCH~zf-CCCH","NA","Eukaryota","Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis"]
["YDR227W","SIR4",6320433,10,2,0,0,"NA","NA","Saccharomyces","Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan"]
["YDR255C","RMD5",6320461,10,11,0,0,"DUF806","NA","Eukaryota","Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis"]
["YDR287W","INM2",6320493,10,7,0,0,"Inositol_P","3.1.3.25_Inositol-phosphate phosphatase","cellular organisms","Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy"]
["YDR333C","YDR333C",6320540,10,18,1,0,"DUF654","NA","cellular organisms","NA"]
["YDR359C","EAF1",42742058,10,25,0,0,"HSA","NA","Ascomycota","Component of the NuA4 histone acetyltransferase complex; required for initiation of pre-meiotic DNA replication, probably due to its requirement for significant expression of IME1"]
["YDR498C","SEC20",6320706,10,4,0,0,"Sec20","NA","Ascomycota","Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p"]
["YDR505C","PSP1",6320713,10,16,0,0,"PSP1","NA","Saccharomycetales","Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition"]
["YEL018W","EAF5",6320818,10,11,0,0,"NA","NA","Saccharomycetaceae","Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex"]
["YEL042W","GDA1",6320793,10,19,0,0,"GDA1_CD39","3.6.1.42_Guanosine-diphosphatase","cellular organisms","Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate"]
["YER006W","NUG1",6320842,10,2,0,0,"GN3L_Grn1~MMR_HSR1~MMR_HSR1","NA","cellular organisms","GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus"]
["YER038C","KRE29",6320876,10,7,0,0,"Nse5","NA","Saccharomycetaceae","Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance"]
["YER072W","VTC1",6320916,10,23,0,0,"DUF202","NA","Eukaryota","Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase"]
["YER110C","KAP123",6320956,10,7,0,0,"IBN_N~HEAT","NA","Eukaryota","Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1"]
["YFL049W","SWP82",14318470,10,12,0,0,"CRC_subunit","NA","Saccharomycetaceae","Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p"]
["YFL052W","YFL052W",14318467,10,8,1,0,"Zn_clus~Fungal_trans","NA","Ascomycota","NA"]
["YFL055W","AGP3",14318464,10,6,0,0,"AA_permease","NA","cellular organisms","Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition"]
["YGL014W","PUF4",6321424,10,10,0,0,"PUF~PUF~PUF~PUF~PUF~PUF~PUF~PUF","NA","Eukaryota","Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors"]
["YGL037C","PNC1",6321401,10,4,0,0,"Isochorismatase~Isochorismatase","3.5.1.19_Nicotinamidase","cellular organisms","Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span"]
["YGL153W","PEX14",6321285,10,18,0,0,"Pex14_N","NA","Eukaryota","Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p"]
["YGL208W","SIP2",6321230,10,5,0,0,"AMPKBI","NA","Eukaryota","One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane"]
["YGL252C","RTG2",6321185,10,13,0,0,"Ppx-GppA","NA","cellular organisms","Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p"]
["YGR003W","CUL3",6321440,10,4,0,0,"Cullin~Cullin_Nedd8","NA","Eukaryota","Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21"]
["YGR008C","STF2",6321445,10,4,0,0,"HABP4_PAI-RBP1","NA","Saccharomycetales","Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein"]
["YGR013W","SNU71",6321450,10,6,0,0,"NA","NA","Saccharomycetales","Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart"]
["YGR149W","YGR149W",6321588,10,4,1,0,"NA","NA","Eukaryota","NA"]
["YGR192C","TDH3",6321631,10,10,0,0,"DapB_N~Gp_dh_N~Gp_dh_C","1.2.1.12_Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)","cellular organisms","Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall"]
["YGR216C","GPI1",6321655,10,4,0,0,"Gpi1","2.4.1.198_Phosphatidylinositol N-acetylglucosaminyltransferase","Eukaryota","Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs"]
["YGR237C","YGR237C",6321676,10,26,1,0,"NA","NA","Saccharomycetales","NA"]
["YHL002W","HSE1",6321785,10,15,0,0,"VHS~SH3_1~SH3_2","NA","Fungi/Metazoa group","Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes"]
["YHR080C","YHR080C",6321872,10,5,0,0,"GRAM","NA","Eukaryota","NA"]
["YHR091C","MSR1",6321883,10,5,0,0,"Arg_tRNA_synt_N~tRNA-synt_1d~DALR_1","6.1.1.19_Arginine--tRNA ligase","cellular organisms","Mitochondrial arginyl-tRNA synthetase"]
["YHR153C","SPO16",6321947,10,6,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, required for spore formation"]
["YIL017C","VID28",6322172,10,17,0,0,"NA","NA","Eukaryota","Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm"]
["YIR001C","SGN1",6322191,10,9,0,0,"RRM_1","NA","cellular organisms","Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation"]
["YIR002C","MPH1",6322192,10,12,0,0,"ResIII~DEAD~Helicase_C","NA","cellular organisms","Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype"]
["YIR005W","IST3",6322195,10,10,0,0,"RRM_1","NA","cellular organisms","Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing"]
["YJL030W","MAD2",6322430,10,11,0,0,"HORMA","NA","Eukaryota","Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p"]
["YJL062W","LAS21",6322399,10,9,0,0,"NA","NA","Eukaryota","Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity"]
["YJL076W","NET1",6322385,10,5,0,0,"Cytokin_check_N","NA","Saccharomycetaceae","Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure"]
["YJL122W","ALB1",6322339,10,7,0,0,"Alb1","NA","Saccharomycetales","Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p"]
["YJR056C","YJR056C",6322516,10,8,1,0,"NA","NA","Ascomycota","NA"]
["YJR075W","HOC1",6322535,10,25,0,0,"Gly_transf_sug","NA","cellular organisms","Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele"]
["YJR117W","STE24",6322577,10,20,0,0,"Peptidase_M48~Peptidase_M48","NA","cellular organisms","Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans"]
["YKL054C","DEF1",6322796,10,19,0,0,"NA","NA","Saccharomycetales","RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis"]
["YKL105C","YKL105C",6322744,10,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKL149C","DBR1",6322700,10,13,0,0,"Metallophos~DBR1","NA","cellular organisms","RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition"]
["YKL218C","SRY1",6322631,10,14,0,0,"PALP","4.3.1.16_Threo-3-hydroxyaspartate ammonia-lyase","cellular organisms","3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate"]
["YKR069W","MET1",6322922,10,7,0,0,"TP_methylase","2.1.1.107_Uroporphyrinogen-III C-methyltransferase","cellular organisms","S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis"]
["YLL040C","VPS13",6322988,10,38,0,0,"DUF1162","NA","Eukaryota","Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention"]
["YLR011W","LOT6",6323039,10,7,0,0,"FMN_red~Flavodoxin_2","1.5.1.29_FMN reductase","cellular organisms","FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature"]
["YLR023C","IZH3",6323051,10,8,0,0,"HlyIII","NA","Eukaryota","Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity"]
["YLR073C","YLR073C",6323102,10,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLR081W","GAL2",6323110,10,9,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Galactose permease, required for utilization of galactose; also able to transport glucose"]
["YLR120C","YPS1",6323149,10,12,0,0,"Asp","3.4.23.41_Yapsin 1","Eukaryota","Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"]
["YLR135W","SLX4",6323164,10,18,0,0,"Slx4","NA","Saccharomycetaceae","Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p"]
["YLR174W","IDP2",6323203,10,8,0,0,"Iso_dh~Iso_dh","1.1.1.42_Isocitrate dehydrogenase (NADP(+))","cellular organisms","Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose"]
["YLR278C","YLR278C",6323308,10,8,1,0,"Zn_clus~Fungal_trans","NA","Ascomycota","NA"]
["YLR287C","YLR287C",6323317,10,9,1,0,"NA","NA","Saccharomycetales","NA"]
["YLR321C","SFH1",6323354,10,8,0,0,"SNF5","NA","Eukaryota","Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog"]
["YLR330W","CHS5",6323362,10,59,0,0,"fn3~BRCT","NA","cellular organisms","Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane"]
["YLR371W","ROM2",6323403,10,17,0,0,"DEP~RhoGEF~CNH","NA","Dikarya","GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP"]
["YLR388W","RPS29A",6323420,10,9,0,0,"Ribosomal_S14","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins"]
["YML021C","UNG1",6323620,10,21,0,0,"UDG","NA","cellular organisms","Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus"]
["YML096W","YML096W",6323542,10,7,1,0,"Asn_synthase","NA","cellular organisms","NA"]
["YMR025W","CSI1",6323667,10,3,0,0,"NA","NA","Saccharomycetaceae","Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"]
["YMR027W","YMR027W",6323669,10,5,1,0,"DUF89","NA","cellular organisms","NA"]
["YMR040W","YET2",6323683,10,3,0,0,"Bap31","NA","Dikarya","Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein"]
["YMR075W","RCO1",6323720,10,5,0,0,"PHD","NA","Fungi/Metazoa group","Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p"]
["YMR182C","RGM1",6323836,10,4,0,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth"]
["YMR265C","YMR265C",6323921,10,7,1,0,"DUF2410","NA","Eukaryota","NA"]
["YMR276W","DSK2",6323932,10,11,0,0,"ubiquitin~UBA","NA","Eukaryota","Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome"]
["YNL099C","OCA1",6324230,10,26,0,0,"Y_phosphatase2","3.1.3.48_Protein-tyrosine-phosphatase","cellular organisms","Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA"]
["YNL102W","POL1",6324227,10,8,0,0,"DNA_pol_B_exo~DNA_pol_B~zf-DNA_Pol","2.7.7.7_DNA-directed DNA polymerase","cellular organisms","Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis"]
["YNL134C","YNL134C",6324195,10,7,1,0,"ADH_zinc_N","NA","cellular organisms","NA"]
["YNL268W","LYP1",6324061,10,18,0,0,"AA_permease","NA","cellular organisms","Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids"]
["YNR056C","BIO5",6324384,10,6,0,0,"NA","NA","cellular organisms","Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis"]
["YOL051W","GAL11",6324522,10,28,0,0,"GAL11","NA","Saccharomycetaceae","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors"]
["YOL061W","PRS5",6324511,10,18,0,0,"Pribosyltran~Pribosyltran","2.7.6.1_Ribose-phosphate diphosphokinase","cellular organisms","5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"]
["YOL082W","ATG19",6324490,10,10,0,0,"NA","NA","Saccharomycetaceae","Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles"]
["YOL132W","GAS4",6324440,10,9,0,0,"Glyco_hydro_72","NA","cellular organisms","1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall"]
["YOR019W","YOR019W",6324593,10,7,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR073W","SGO1",6324647,10,5,0,0,"Shugoshin_N~Shugoshin_C","NA","Saccharomycetaceae","Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability"]
["YOR074C","CDC21",83578104,10,11,0,0,"Thymidylat_synt","2.1.1.45_Thymidylate synthase","cellular organisms","Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S"]
["YOR152C","YOR152C",6324726,10,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR178C","GAC1",6324752,10,5,0,0,"CBM_21","NA","Saccharomycetales","Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock"]
["YOR188W","MSB1",6324762,10,10,0,0,"DUF1708","NA","Ascomycota","Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4"]
["YOR230W","WTM1",6324804,10,6,0,0,"WD40","NA","Eukaryota","Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats"]
["YOR303W","CPA1",6324878,10,14,0,0,"CPSase_sm_chain~GATase~Peptidase_C26","6.3.5.5_Carbamoyl-phosphate synthase (glutamine-hydrolyzing)","cellular organisms","Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader"]
["YOR357C","SNX3",6324933,10,24,0,0,"PX","NA","Eukaryota","Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p"]
["YOR367W","SCP1",6324943,10,5,0,0,"CH","NA","Eukaryota","Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin"]
["YPL008W","CHL1",6325249,10,9,0,0,"DEAD_2","NA","cellular organisms","Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p"]
["YPL041C","YPL041C",6325216,10,15,1,0,"FLILHELTA","NA","Ascomycota","NA"]
["YPL056C","YPL056C",6325201,10,15,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YPL101W","ELP4",6325155,10,13,0,0,"PAXNEB","NA","Eukaryota","Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity"]
["YPL195W","APL5",6325061,10,30,0,0,"Adaptin_N","NA","Eukaryota","Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function"]
["YPL218W","SAR1",6325038,10,3,0,0,"Arf~MMR_HSR1~Miro","NA","cellular organisms","GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport"]
["YPR023C","EAF3",6325280,10,27,0,0,"MRG","NA","Eukaryota","Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition"]
["YPR029C","APL4",6325286,10,21,0,0,"Adaptin_N~Alpha_adaptinC2","NA","Eukaryota","Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport"]
["YPR069C","SPE3",6325326,10,13,0,0,"Spermine_synth~Methyltransf_12","2.5.1.16_Spermidine synthase","cellular organisms","Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells"]
["YPR113W","PIS1",6325370,10,5,0,0,"CDP-OH_P_transf","2.7.8.11_CDP-diacylglycerol--inositol 3-phosphatidyltransferase","cellular organisms","Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins"]
["YPR141C","KAR3",6325399,10,8,0,0,"Kinesin","NA","Eukaryota","Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate"]
["YPR147C","YPR147C",6325405,10,3,1,0,"DUF2305","NA","Eukaryota","NA"]
["YCR083W","TRX3",6319925,10,6,0,1,"Thioredoxin~Redoxin~AhpC-TSA~DSBA","NA","cellular organisms","Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p"]
["YDR529C","QCR7",6320738,10,8,0,1,"UCR_14kD","NA","Eukaryota","Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly"]
["YER017C","AFG3",6320854,10,23,0,1,"FtsH_ext~AAA~AAA_2~Mg_chelatase~Peptidase_M41","NA","cellular organisms","Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"]
["YGL211W","NCS6",50593215,10,11,0,1,"ATP_bind_3~ATP_bind_3","NA","cellular organisms","Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae"]
["YGR231C","PHB2",50593217,10,12,0,1,"Band_7","NA","cellular organisms","Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"]
["YKL167C","MRP49",6322681,10,10,0,1,"L51_S25_CI-B8","NA","Ascomycota","Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"]
["YKR066C","CCP1",6322919,10,9,0,1,"peroxidase","1.11.1.5_Cytochrome-c peroxidase","cellular organisms","Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress"]
["YLL041C","SDH2",6322987,10,7,0,1,"Fer2","1.3.5.1_Succinate dehydrogenase (ubiquinone)","cellular organisms","Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone"]
["YNR045W","PET494",6324373,10,13,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane"]
["YAL042W","ERV46",6319274,9,20,0,0,"DUF1692","NA","Eukaryota","Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport"]
["YAL058W","CNE1",6319260,9,22,0,0,"Calreticulin","NA","Eukaryota","Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast"]
["YBL020W","RFT1",6319451,9,8,0,0,"Rft-1","NA","Eukaryota","Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein"]
["YBL024W","NCL1",6319447,9,25,0,0,"Nol1_Nop2_Fmu~FtsJ~Nol1_Nop2_Fmu","2.1.1.29_tRNA (cytosine-5-)-methyltransferase","cellular organisms","S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120"]
["YBL037W","APL3",6319434,9,13,0,0,"Adaptin_N~Alpha_adaptinC2","NA","Eukaryota","Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport"]
["YBL046W","PSY4",6319425,9,53,0,0,"PPP4R2","NA","Saccharomycetales","Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus"]
["YBL072C","RPS8A",6319399,9,16,0,0,"Ribosomal_S8e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein"]
["YBR055C","PRP6",6319529,9,2,0,0,"PRP1_N~SPO22","NA","Eukaryota","Splicing factor, component of the U4/U6-U5 snRNP complex"]
["YBR083W","TEC1",6319557,9,8,0,0,"TEA","NA","Fungi/Metazoa group","Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member"]
["YBR097W","VPS15",6319573,9,11,0,0,"Pkinase~Pkinase~WD40","NA","Eukaryota","Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p"]
["YBR105C","VID24",6319581,9,14,0,0,"Vac_ImportDeg","NA","Eukaryota","Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase"]
["YBR107C","IML3",6319583,9,9,0,0,"NA","NA","Saccharomycetaceae","Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p"]
["YBR112C","CYC8",6319589,9,17,0,0,"TPR_1~TPR_2~TPR_1~TPR_2~TPR_1~TPR_2~TPR_1~TPR_1~TPR_2~TPR_2~TPR_1~TPR_2","NA","cellular organisms","General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters"]
["YBR114W","RAD16",6319590,9,7,0,0,"SNF2_N~DEAD~zf-C3HC4~Helicase_C","NA","cellular organisms","Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex"]
["YBR140C","IRA1",6319616,9,18,0,0,"RasGAP","NA","Fungi/Metazoa group","GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase"]
["YBR198C","TAF5",6319675,9,11,0,0,"LisH~TFIID_90kDa~WD40~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification"]
["YBR213W","MET8",6319690,9,5,0,0,"NA","1.3.1.76_Precorrin-2 dehydrogenase|4.99.1.4_Sirohydrochlorin ferrochelatase","cellular organisms","Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis"]
["YBR256C","RIB5",6319733,9,4,0,0,"Lum_binding~Lum_binding","2.5.1.9_Riboflavin synthase","cellular organisms","Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway"]
["YBR276C","PPS1",6319753,9,13,0,0,"DSPc~DSPc","3.1.3.16_Phosphoprotein phosphatase|3.1.3.48_Protein-tyrosine-phosphatase","Dikarya","Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle"]
["YCL048W","SPS22",6319801,9,4,0,0,"Recep_L_domain","NA","cellular organisms","Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall"]
["YCR002C","CDC10",6319847,9,16,0,0,"Septin~IIGP~DUF258","NA","cellular organisms","Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"]
["YCR044C","PER1",6319892,9,22,0,0,"Per1","NA","Eukaryota","Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1"]
["YDL025C","YDL025C",6320179,9,10,1,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","NA"]
["YDL040C","NAT1",6320164,9,9,0,0,"TPR_2","NA","cellular organisms","Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"]
["YDL133C-A","RPL41B",6320068,9,7,0,0,"Ribosomal_L41","NA","Saccharomyces cerevisiae","Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable"]
["YDL204W","RTN2",6319997,9,3,0,0,"Reticulon","NA","Fungi/Metazoa group","Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily"]
["YDL236W","PHO13",6319965,9,17,0,0,"Hydrolase","3.1.3.41_4-nitrophenylphosphatase","cellular organisms","Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein"]
["YDR028C","REG1",6320231,9,19,0,0,"DUF812","NA","Saccharomycetales","Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes"]
["YDR057W","YOS9",6320262,9,31,0,0,"NA","NA","Eukaryota","ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family"]
["YDR074W","TPS2",6320279,9,11,0,0,"Glyco_transf_20~Trehalose_PPase","3.1.3.12_Trehalose-phosphatase","cellular organisms","Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway"]
["YDR140W","MTQ2",6320344,9,5,0,0,"NA","NA","cellular organisms","S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC"]
["YDR216W","ADR1",6320422,9,6,0,0,"zf-C2H2~zf-C2H2","NA","Saccharomycetales","Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization"]
["YDR235W","PRP42",6320441,9,6,0,0,"NA","NA","Eukaryota","U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats"]
["YDR348C","YDR348C",6320555,9,19,1,0,"Pal1","NA","Ascomycota","NA"]
["YDR350C","ATP22",6320557,9,12,0,0,"NA","NA","Saccharomycetaceae","Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YDR383C","NKP1",37362634,9,15,0,0,"NA","NA","Saccharomycetaceae","Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)"]
["YDR444W","YDR444W",6320652,9,8,1,0,"DUF676","NA","Eukaryota","NA"]
["YDR447C","RPS17B",6320655,9,3,0,0,"Ribosomal_S17e","NA","cellular organisms","Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein"]
["YDR456W","NHX1",6320663,9,28,0,0,"Na_H_Exchanger","NA","cellular organisms","Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock"]
["YDR471W","RPL27B",6320679,9,6,0,0,"KOW~Ribosomal_L27e","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein"]
["YDR476C","YDR476C",6320684,9,7,1,0,"NA","NA","Saccharomycetales","NA"]
["YDR482C","CWC21",6320690,9,10,0,0,"cwf21","NA","Eukaryota","Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p"]
["YDR497C","ITR1",6320705,9,8,0,0,"Sugar_tr~MFS_1~MFS_1","NA","cellular organisms","Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p"]
["YDR500C","RPL37B",6320708,9,7,0,0,"Ribosomal_L37e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein"]
["YEL027W","CUP5",6320808,9,34,0,0,"ATP-synt_C~ATP-synt_C","NA","cellular organisms","Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis"]
["YEL048C","YEL048C",6320787,9,26,1,0,"NA","NA","Saccharomycetales","NA"]
["YEL050C","RML2",6320785,9,13,0,0,"Ribosomal_L2~Ribosomal_L2_C","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor"]
["YEL053C","MAK10",6320782,9,32,0,0,"Mak10","NA","Fungi/Metazoa group","Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible"]
["YER014C-A","BUD25",13112038,9,15,0,0,"NA","NA","Saccharomyces cerevisiae","Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YER037W","PHM8",6320875,9,14,0,0,"Hydrolase","NA","cellular organisms","Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p"]
["YFL010C","WWM1",18702303,9,7,0,0,"WW","NA","Ascomycota","WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1"]
["YFL030W","AGX1",14318489,9,5,0,0,"Aminotran_5","2.6.1.44_Alanine--glyoxylate transaminase","cellular organisms","Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases"]
["YFR019W","FAB1",14318541,9,15,0,0,"FYVE~Cpn60_TCP1~PIP5K~PIP5K","2.7.1.150_1-phosphatidylinositol-3-phosphate 5-kinase","Eukaryota","1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis"]
["YGL038C","OCH1",6321400,9,8,0,0,"Gly_transf_sug","2.4.1.232_Initiation-specific alpha-1,6-mannosyltransferase","cellular organisms","Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins"]
["YGL095C","VPS45",6321343,9,13,0,0,"Sec1","NA","Eukaryota","Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment"]
["YGL110C","CUE3",6321328,9,5,0,0,"CUE","NA","Dikarya","Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination"]
["YGL115W","SNF4",6321323,9,11,0,0,"CBS~CBS~CBS","NA","cellular organisms","Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis"]
["YGL140C","YGL140C",6321298,9,7,1,0,"NA","NA","Dikarya","NA"]
["YGL180W","ATG1",6321258,9,3,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p"]
["YGL181W","GTS1",6321257,9,3,0,0,"ArfGap~UBA","NA","Eukaryota","Protein that localizes to the nucleus and is involved in transcription regulation; also localizes to actin patches and plays a role in endocytosis; N-terminus contains an ARF-GAP domain and C-terminus contains a Gln-rich domain"]
["YGL242C","YGL242C",6321195,9,8,1,0,"Ank~Ank","NA","cellular organisms","NA"]
["YGL248W","PDE1",6321189,9,11,0,0,"PDEase_II","3.1.4.17_3',5'-cyclic-nucleotide phosphodiesterase","cellular organisms","Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation"]
["YGL263W","COS12",6321174,9,6,0,0,"DUP~DUP","NA","Saccharomycetaceae","Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"]
["YGR017W","YGR017W",6321454,9,14,1,0,"NA","NA","cellular organisms","NA"]
["YGR040W","KSS1",6321477,9,7,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.24_Mitogen-activated protein kinase","cellular organisms","Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains"]
["YGR083C","GCD2",6321520,9,15,0,0,"IF-2B","NA","cellular organisms","Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"]
["YGR089W","NNF2",6321526,9,18,0,0,"DivIC","NA","Ascomycota","Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation"]
["YGR098C","ESP1",6321535,9,7,0,0,"Peptidase_C50","3.4.22.49_Separase","Ascomycota","Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p"]
["YGR104C","SRB5",6321541,9,16,0,0,"Med18~Med18","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance"]
["YGR199W","PMT6",6321638,9,4,0,0,"PMT~MIR","2.4.1.109_Dolichyl-phosphate-mannose-protein mannosyltransferase","cellular organisms","Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases"]
["YGR205W","YGR205W",6321644,9,9,0,0,"NA","NA","cellular organisms","NA"]
["YGR247W","CPD1",6321686,9,12,0,0,"CPDase","3.1.4.37_2',3'-cyclic-nucleotide 3'-phosphodiesterase","Saccharomycetales","Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression"]
["YGR283C","YGR283C",6321722,9,7,0,0,"DUF171","NA","Eukaryota","NA"]
["YHL013C","OTU2",6321774,9,8,0,0,"OTU","NA","Eukaryota","Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization"]
["YHL019C","APM2",6321768,9,31,0,0,"Adap_comp_sub","NA","Eukaryota","Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport"]
["YHL025W","SNF6",6321762,9,15,0,0,"NA","NA","Saccharomycetaceae","Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p"]
["YHR004C","NEM1",6321791,9,20,0,0,"NIF","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation"]
["YHR178W","STB5",6321972,9,23,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay"]
["YHR182W","YHR182W",6321976,9,4,1,0,"RhoGAP","NA","Saccharomycetaceae","NA"]
["YIL048W","NEO1",6322141,9,48,0,0,"E1-E2_ATPase~Hydrolase","3.6.3.1_Phospholipid-translocating ATPase","cellular organisms","Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus"]
["YIL164C","NIT1",6322027,9,7,0,0,"CN_hydrolase","NA","cellular organisms","Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene"]
["YJL004C","SYS1",6322456,9,49,0,0,"SYS1","NA","Eukaryota","Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation"]
["YJL014W","CCT3",6322446,9,30,0,0,"Cpn60_TCP1","NA","cellular organisms","Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"]
["YJL053W","PEP8",6322408,9,53,0,0,"Vps26","NA","Eukaryota","Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport"]
["YJL115W","ASF1",6322346,9,22,0,0,"ASF1_hist_chap","NA","Eukaryota","Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition"]
["YJL127C","SPT10",6322334,9,11,0,0,"Acetyltransf_1~zf-H2C2","NA","cellular organisms","Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box"]
["YJL141C","YAK1",6322320,9,10,0,0,"Pkinase~Pkinase","2.7.12.1_Dual-specificity kinase","cellular organisms","Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal"]
["YJL157C","FAR1",6322304,9,13,0,0,"NA","NA","Saccharomycetales","Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate"]
["YJL159W","HSP150",116006493,9,24,0,0,"PIR~PIR~PIR~PIR~PIR~PIR~PIR~PIR~PIR~PIR~PIR","NA","Eukaryota","O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation"]
["YJL197W","UBP12",6322264,9,7,0,0,"UCH","NA","Eukaryota","Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins"]
["YJL212C","OPT1",6322249,9,9,0,0,"OPT","NA","Eukaryota","Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family"]
["YJR025C","BNA1",6322485,9,11,0,0,"3-HAO~Cupin_2~DUF2296","1.13.11.6_3-hydroxyanthranilate 3,4-dioxygenase","cellular organisms","3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"]
["YJR076C","CDC11",6322536,9,4,0,0,"Septin~MMR_HSR1~IIGP","NA","Eukaryota","Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"]
["YJR097W","JJJ3",6322557,9,15,0,0,"DnaJ~zf-CSL","NA","cellular organisms","Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein"]
["YJR120W","YJR120W",6322580,9,12,0,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YJR126C","VPS70",6322586,9,11,0,0,"PA~Peptidase_M28","NA","cellular organisms","Protein of unknown function involved in vacuolar protein sorting"]
["YJR139C","HOM6",6322599,9,58,0,0,"NAD_binding_3~Homoserine_dh","1.1.1.3_Homoserine dehydrogenase","cellular organisms","Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions"]
["YJR140C","HIR3",6322600,9,27,0,0,"NA","NA","Ascomycota","Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly"]
["YKL018W","SWD2",6322834,9,7,0,0,"WD40","NA","cellular organisms","Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination"]
["YKL090W","CUE2",6322760,9,8,0,0,"CUE~CUE~Smr","NA","Saccharomycetales","Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination"]
["YKL099C","UTP11",83722564,9,6,0,0,"Utp11","NA","Eukaryota","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YKL110C","KTI12",6322739,9,9,0,0,"KTI12~APS_kinase","NA","cellular organisms","Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p"]
["YKL187C","YKL187C",6322661,9,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKL204W","EAP1",6322645,9,16,0,0,"NA","NA","Saccharomycetales","eIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade"]
["YKL209C","STE6",6322640,9,3,0,0,"ABC_membrane~ABC_tran~ABC_membrane~ATP-synt_ab~ABC_tran~AAA_5","NA","Saccharomyces cerevisiae","Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells"]
["YKR024C","DBP7",6322876,9,8,0,0,"DEAD~Helicase_C","NA","cellular organisms","Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis"]
["YKR094C","RPL40B",6322947,9,3,0,0,"ubiquitin~Ribosomal_L40e","NA","cellular organisms","Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes"]
["YLL056C","YLL056C",6322972,9,11,1,0,"RmlD_sub_bind~Epimerase~NAD_binding_4~F420_oxidored","NA","cellular organisms","NA"]
["YLR068W","FYV7",6323097,9,17,0,0,"rRNA_processing","NA","Saccharomycetales","Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts"]
["YLR118C","YLR118C",6323147,9,5,0,0,"Abhydrolase_2","NA","cellular organisms","NA"]
["YLR210W","CLB4",6323239,9,4,0,0,"Cyclin_N~Cyclin_C","NA","Eukaryota","B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation"]
["YLR238W","FAR10",6323267,9,7,0,0,"FHA","NA","Ascomycota","Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate"]
["YLR363C","NMD4",6323395,9,5,0,0,"NA","NA","Saccharomycetales","Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway"]
["YLR384C","IKI3",6323416,9,5,0,0,"IKI3","NA","Eukaryota","Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)"]
["YLR404W","FLD1",6323436,9,6,0,0,"NA","NA","Saccharomycetaceae","Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy"]
["YLR410W","VIP1",6323442,9,10,0,0,"RimK~Acid_phosphat_A","2.7.4.21_Inositol-hexakisphosphate kinase|2.7.4.24_Diphosphoinositol-pentakisphosphate kinase","Eukaryota","Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1"]
["YLR421C","RPN13",6323453,9,11,0,0,"ARM_1","NA","Fungi/Metazoa group","Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome"]
["YLR443W","ECM7",6323476,9,12,0,0,"NA","NA","Saccharomycetales","Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency"]
["YMR001C","CDC5",6323643,9,12,0,0,"Pkinase~Pkinase_Tyr~POLO_box~POLO_box","2.7.11.21_Polo kinase","cellular organisms","Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate"]
["YMR030W","RSF1",6323672,9,3,0,0,"NA","NA","Saccharomyces cerevisiae","Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth"]
["YMR109W","MYO5",6323756,9,27,0,0,"Myosin_head~Myosin_TH1~SH3_1~SH3_2","NA","Eukaryota","One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization"]
["YMR202W","ERG2",6323858,9,20,0,0,"ERG2_Sigma1R","NA","cellular organisms","C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis"]
["YMR213W","CEF1",6323869,9,5,0,0,"Myb_DNA-binding~Myb_DNA-binding","NA","Eukaryota","Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p"]
["YMR270C","RRN9",6323926,9,5,0,0,"RRN9","NA","Saccharomycetaceae","Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I"]
["YMR291W","YMR291W",6323948,9,6,1,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","NA"]
["YMR316W","DIA1",6323976,9,28,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YMR318C","ADH6",6323980,9,7,0,0,"ADH_N~2-Hacid_dh_C~ADH_zinc_N","1.1.1.2_Alcohol dehydrogenase (NADP(+))","cellular organisms","NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance"]
["YNL004W","HRB1",154199622,9,7,0,0,"RRM_1~RRM_1~RRM_1","NA","cellular organisms","Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p"]
["YNL045W","YNL045W",6324283,9,4,0,0,"Peptidase_M1~Leuk-A4-hydro_C","NA","cellular organisms","NA"]
["YNL049C","SFB2",6324279,9,8,0,0,"zf-Sec23_Sec24~Sec23_trunk~Sec23_trunk~Sec23_BS~Sec23_helical~Gelsolin","NA","Eukaryota","Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy"]
["YNL076W","MKS1",6324253,9,18,0,0,"NA","NA","Saccharomycetaceae","Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling"]
["YNL115C","YNL115C",6324214,9,18,1,0,"DUF2417~Abhydrolase_1","NA","cellular organisms","NA"]
["YNL132W","KRE33",6324197,9,9,0,0,"DUF1726~DUF699","NA","cellular organisms","Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance"]
["YNL200C","YNL200C",6324129,9,6,1,0,"YjeF_N","NA","cellular organisms","NA"]
["YNL201C","PSY2",6324128,9,36,0,0,"DUF625","NA","Eukaryota","Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus"]
["YNL248C","RPA49",6324081,9,10,0,0,"RNA_pol_I_A49","NA","Eukaryota","RNA polymerase I subunit A49"]
["YNL305C","YNL305C",6324024,9,8,1,0,"UPF0005","NA","cellular organisms","NA"]
["YNR010W","CSE2",6324337,9,8,0,0,"CSE2","NA","Saccharomycetaceae","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity"]
["YOL007C","CSI2",6324567,9,6,0,0,"NA","NA","Saccharomycetales","Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene"]
["YOL045W","PSK2",6324527,9,19,0,0,"Pkinase~APH","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)"]
["YOL048C","YOL048C",37362693,9,5,1,0,"UAA","NA","Dikarya","NA"]
["YOL049W","GSH2",6324524,9,18,0,0,"GSH_synth_ATP~GSH_synthase","6.3.2.3_Glutathione synthase","cellular organisms","Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock"]
["YOL076W","MDM20",6324497,9,34,0,0,"NatB_MDM20","NA","Fungi/Metazoa group","Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly"]
["YOL090W","MSH2",6324482,9,24,0,0,"MutS_I~MutS_II~MutS_III~MutS_IV~MutS_V","NA","cellular organisms","Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP"]
["YOL091W","SPO21",6324481,9,8,0,0,"NA","NA","Saccharomyces cerevisiae","Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation"]
["YOL102C","TPT1",6324470,9,4,0,0,"PTS_2-RNA","2.7.1.160_2'-phosphotransferase","cellular organisms","tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide"]
["YOL144W","NOP8",6324428,9,16,0,0,"RRM_1","NA","Saccharomycetales","Nucleolar protein required for 60S ribosomal subunit biogenesis"]
["YOL163W","YOL163W",6324410,9,5,1,0,"MFS_1","NA","cellular organisms","NA"]
["YOR009W","TIR4",6324583,9,3,0,0,"SRP1_TIP1","NA","cellular organisms","Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock"]
["YOR124C","UBP2",6324698,9,15,0,0,"UCH","3.1.2.15_Ubiquitin thiolesterase","Eukaryota","Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity"]
["YOR125C","CAT5",37362696,9,12,0,0,"COQ7~COQ7~COQ7","NA","cellular organisms","Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation"]
["YOR138C","RUP1",6324712,9,10,0,0,"UBA","NA","Saccharomycetales","Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain"]
["YOR229W","WTM2",6324803,9,11,0,0,"WD40","NA","Eukaryota","Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats"]
["YOR279C","RFM1",6324853,9,23,0,0,"NA","NA","Saccharomycetaceae","DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance"]
["YPL071C","YPL071C",6325186,9,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL096W","PNG1",6325161,9,4,0,0,"Desulfoferrod_N~Transglut_core~Rad4","3.5.1.52_Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase","Eukaryota","Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p"]
["YPL154C","PEP4",6325103,9,13,0,0,"Asp","3.4.23.25_Saccharopepsin","cellular organisms","Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates"]
["YPL170W","DAP1",6325087,9,21,0,0,"Cyt-b5","NA","Eukaryota","Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis"]
["YPL250C","ICY2",6325005,9,5,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate"]
["YPL254W","HFI1",6325001,9,31,0,0,"NA","NA","Ascomycota","Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions"]
["YPR158W","YPR158W",6325416,9,7,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YBL099W","ATP1",6319370,9,16,0,1,"ATP-synt_ab_N~HAS-barrel~ATP-synt_ab~ATP-synt_ab_C","NA","cellular organisms","Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"]
["YBR104W","YMC2",6319580,9,8,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p"]
["YDL202W","MRPL11",6319999,9,5,0,1,"NA","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YJL166W","QCR8",6322295,9,12,0,1,"UcrQ","NA","Dikarya","Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p"]
["YKL208W","CBT1",6322641,9,9,0,1,"NA","NA","Saccharomycetaceae","Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p"]
["YLR203C","MSS51",6323232,9,9,0,1,"NA","NA","Dikarya","Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein"]
["YLR259C","HSP60",6323288,9,7,0,1,"Cpn60_TCP1","NA","cellular organisms","Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated"]
["YML110C","COQ5",6323526,9,6,0,1,"Ubie_methyltran~Methyltransf_12~Methyltransf_11~Methyltransf_8","NA","cellular organisms","2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes"]
["YMR072W","ABF2",6323717,9,6,0,1,"HMG_box~HMG_box","NA","Eukaryota","Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation"]
["YOL071W","EMI5",6324501,9,7,0,1,"DUF339","NA","cellular organisms","Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation"]
["YOR037W","CYC2",37362694,9,6,0,1,"FAD_binding_6","NA","Dikarya","Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)"]
["YOR136W","IDH2",6324709,9,7,0,1,"Iso_dh","1.1.1.41_Isocitrate dehydrogenase (NAD(+))","cellular organisms","Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated"]
["YAL048C","GEM1",6319268,8,11,0,0,"Miro~Ras~EF_assoc_2~efhand~EF_assoc_1~Miro","NA","Eukaryota","Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death"]
["YAL055W","PEX22",6319263,8,24,0,0,"NA","NA","Saccharomycetaceae","Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation"]
["YAL068C","PAU8",6319249,8,10,1,0,"SRP1_TIP1","NA","Saccharomycetaceae","Hypothetical protein"]
["YAR027W","UIP3",6319331,8,7,0,0,"DUP","NA","Saccharomycetaceae","Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family"]
["YBL019W","APN2",6319452,8,9,0,0,"Exo_endo_phos~zf-GRF","4.2.99.18_DNA-(apurinic or apyrimidinic site) lyase","cellular organisms","Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII"]
["YBL025W","RRN10",6319446,8,9,0,0,"UAF_Rrn10","NA","Saccharomycetales","Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I"]
["YBL029W","YBL029W",6319442,8,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBL105C","PKC1",6319363,8,23,0,0,"HR1~HR1~C1_1~C1_1~Pkinase~Pkinase_Tyr~Pkinase_Tyr~Pkinase_C","2.7.11.13_Protein kinase C","cellular organisms","Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)"]
["YBR049C","REB1",6319523,8,2,0,0,"Myb_DNA-binding~Myb_DNA-binding","NA","Ascomycota","RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription"]
["YBR066C","NRG2",6319540,8,11,0,0,"zf-C2H2~zf-C2H2","NA","Eukaryota","Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p"]
["YBR130C","SHE3",6319606,8,4,0,0,"NA","NA","Saccharomycetales","Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance"]
["YBR171W","SEC66",6319648,8,18,0,0,"Sec66","NA","Dikarya","Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"]
["YBR177C","EHT1",6319655,8,8,0,0,"Abhydrolase_1~CbiX","NA","cellular organisms","Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane"]
["YBR231C","SWC5",6319708,8,26,0,0,"BCNT~DUF1835","NA","Fungi/Metazoa group","Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"]
["YBR239C","ERT1",6319716,8,7,1,0,"Zn_clus~PAS","NA","Dikarya","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; plays a role in restricting Ty1 transposition"]
["YBR243C","ALG7",6319720,8,8,0,0,"Glycos_transf_4","2.7.8.15_N-acetylglucosaminephosphotransferase","cellular organisms","UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin"]
["YBR255W","YBR255W",6319732,8,14,0,0,"NA","NA","Saccharomycetales","Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YBR255W is synthetically sick with cdc13-1"]
["YBR260C","RGD1",6319737,8,18,0,0,"FCH~RhoGAP","NA","Eukaryota","GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization"]
["YBR299W","MAL32",6319776,8,3,0,0,"Alpha-amylase","NA","cellular organisms","Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C"]
["YCL029C","BIK1",6319820,8,9,0,0,"CAP_GLY","NA","Fungi/Metazoa group","Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170"]
["YCL045C","YCL045C",6319804,8,17,1,0,"DUF1620","NA","Eukaryota","NA"]
["YCR021C","HSP30",6319869,8,6,0,0,"NA","NA","Eukaryota","Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase"]
["YCR061W","YCR061W",10383800,8,11,1,0,"DUF2427~Ytp1","NA","Dikarya","NA"]
["YCR092C","MSH3",157285763,8,4,0,0,"MutS_I~MutS_II~MutS_III~MutS_IV~MutS_V","NA","cellular organisms","Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability"]
["YCR095C","OCA4",6319938,8,24,1,0,"Y_phosphatase2~Y_phosphatase2","NA","Eukaryota","Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"]
["YDL018C","ERP3",6320186,8,3,0,0,"EMP24_GP25L","NA","Eukaryota","Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"]
["YDL182W","LYS20",6320019,8,4,0,0,"HMGL-like","2.3.3.14_Homocitrate synthase","cellular organisms","Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p"]
["YDR007W","TRP1",6320210,8,43,0,0,"PRAI","5.3.1.24_Phosphoribosylanthranilate isomerase","cellular organisms","Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)"]
["YDR027C","VPS54",6320230,8,13,0,0,"NA","NA","Eukaryota","Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p"]
["YDR052C","DBF4",6320258,8,5,0,0,"Dfp1_Him1_M~zf-DBF","NA","Ascomycota","Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated"]
["YDR073W","SNF11",6320278,8,19,0,0,"NA","NA","Saccharomycetaceae","Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p"]
["YDR087C","RRP1",6320292,8,3,0,0,"Nop52~Nop52","NA","Eukaryota","Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles"]
["YDR103W","STE5",6320308,8,4,0,0,"NA","NA","Saccharomycetaceae","Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling"]
["YDR172W","SUP35",6320377,8,9,0,0,"GTP_EFTU~GTP_EFTU_D2~GTP_EFTU_D3","NA","cellular organisms","Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype"]
["YDR205W","MSC2",37362632,8,6,0,0,"Cation_efflux","NA","cellular organisms","Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids"]
["YDR260C","SWM1",6320466,8,13,0,0,"Apc13p","NA","Saccharomycetaceae","Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation"]
["YDR261C","EXG2",6320467,8,6,0,0,"Cellulase","3.2.1.58_Glucan 1,3-beta-glucosidase","cellular organisms","Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"]
["YDR310C","SUM1",6320516,8,43,0,0,"NA","NA","Saccharomycetaceae","Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint"]
["YDR318W","MCM21",37362633,8,9,0,0,"DUF881~Fmp27_WPPW~Cenp-O","NA","Saccharomycetales","Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules"]
["YDR414C","ERD1",6320622,8,31,0,0,"EXS","NA","Eukaryota","Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)"]
["YDR446W","ECM11",6320654,8,2,0,0,"NA","NA","Saccharomycetaceae","Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure"]
["YDR450W","RPS18A",6320658,8,7,0,0,"Ribosomal_S13","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins"]
["YDR452W","PPN1",6320660,8,2,0,0,"Metallophos~Methyltrans_Typ","3.6.1.10_Endopolyphosphatase|3.6.1.11_Exopolyphosphatase","Eukaryota","Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer"]
["YDR532C","YDR532C",6320741,8,23,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YEL043W","YEL043W",6320792,8,11,0,0,"NA","NA","Ascomycota","NA"]
["YEL072W","RMD6",6320763,8,11,0,0,"NA","NA","Saccharomycetales","Protein required for sporulation"]
["YER003C","PMI40",6320839,8,3,0,0,"PMI_typeI~AraC_binding","5.3.1.8_Mannose-6-phosphate isomerase","cellular organisms","Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation"]
["YER009W","NTF2",6320846,8,6,0,0,"NTF2","NA","Eukaryota","Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport"]
["YER013W","PRP22",6320850,8,5,0,0,"S1~Helicase_C~HA2~DUF1605","NA","cellular organisms","DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes"]
["YER020W","GPA2",6320858,8,12,0,0,"G-alpha~Arf","NA","Eukaryota","Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"]
["YER074W","RPS24A",6320918,8,5,0,0,"Ribosomal_S24e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein"]
["YER082C","UTP7",6320926,8,4,0,0,"WD40~BING4CT","NA","cellular organisms","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YER092W","IES5",6320938,8,19,0,0,"NA","NA","Saccharomycetaceae","Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions"]
["YER093C","TSC11",6320939,8,23,0,0,"RasGEF_N","NA","Eukaryota","Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain"]
["YER116C","SLX8",6320962,8,14,0,0,"zf-C3HC4","NA","Eukaryota","Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate"]
["YFL040W","YFL040W",14318478,8,9,1,0,"Sugar_tr~MFS_1","NA","cellular organisms","NA"]
["YFL045C","SEC53",14318474,8,3,0,0,"PMM","5.4.2.8_Phosphomannomutase","cellular organisms","Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen"]
["YFR057W","YFR057W",14318582,8,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGL005C","COG7",6321433,8,55,0,0,"NA","NA","Saccharomycetales","Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YGL025C","PGD1",37362652,8,22,0,0,"NA","NA","Saccharomycetaceae","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor"]
["YGL031C","RPL24A",6321407,8,4,0,0,"Ribosomal_L24e","NA","cellular organisms","Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"]
["YGL054C","ERV14",6321384,8,18,0,0,"Cornichon","NA","Eukaryota","Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon"]
["YGL157W","YGL157W",6321281,8,4,0,0,"Epimerase","NA","cellular organisms","NA"]
["YGL194C","HOS2",6321244,8,25,0,0,"Hist_deacetyl","3.5.1.98_Histone deacetylase","cellular organisms","Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity"]
["YGL203C","KEX1",6321235,8,9,0,0,"Peptidase_S10","3.4.16.6_Carboxypeptidase D","cellular organisms","Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins"]
["YGL230C","YGL230C",6321207,8,3,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGR071C","YGR071C",6321508,8,17,1,0,"zf-BED","NA","Saccharomycetaceae","NA"]
["YGR078C","PAC10",6321515,8,21,0,0,"Prefoldin","NA","Eukaryota","Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding"]
["YGR081C","SLX9",6321518,8,10,0,0,"NA","NA","Saccharomycetaceae","Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant"]
["YGR117C","YGR117C",6321555,8,3,1,0,"LisH","NA","Ascomycota","NA"]
["YGR131W","YGR131W",6321570,8,5,1,0,"DUF2503","NA","Ascomycota","NA"]
["YGR196C","FYV8",6321635,8,15,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, required for survival upon exposure to K1 killer toxin"]
["YGR261C","APL6",6321700,8,34,0,0,"Adaptin_N","NA","Eukaryota","Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools"]
["YGR271W","SLH1",6321710,8,8,0,0,"DEAD~ATP-synt_ab~Helicase_C~Sec63~DEAD~ResIII~Helicase_C~Sec63","NA","cellular organisms","Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses"]
["YGR295C","COS6",6321734,8,10,0,0,"DUP~DUP","NA","Saccharomycetaceae","Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"]
["YHL027W","RIM101",6321760,8,55,0,0,"zf-C2H2","NA","Fungi/Metazoa group","Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC"]
["YHL033C","RPL8A",6321754,8,11,0,0,"Ribosomal_L7Ae","NA","cellular organisms","Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"]
["YHR045W","YHR045W",6321835,8,23,1,0,"NA","NA","Ascomycota","NA"]
["YHR046C","INM1",6321836,8,4,0,0,"Inositol_P","3.1.3.25_Inositol-phosphate phosphatase","cellular organisms","Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate"]
["YHR161C","YAP1801",6321955,8,11,0,0,"ANTH~ENTH","NA","Eukaryota","Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family"]
["YHR168W","MTG2",6321962,8,21,0,0,"GTP1_OBG~GTP1_OBG~MMR_HSR1","NA","cellular organisms","Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly"]
["YIL064W","YIL064W",6322125,8,33,0,0,"Methyltransf_11~Methyltransf_12","NA","cellular organisms","NA"]
["YIL104C","SHQ1",6322087,8,7,0,0,"SHQ1","NA","Eukaryota","Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p"]
["YIL112W","HOS4",6322079,8,16,0,0,"Ank~Ank~Ank","NA","cellular organisms","Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate"]
["YIR030C","DCG1",6322221,8,4,0,0,"NA","NA","cellular organisms","Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain"]
["YJL033W","HCA4",6322427,8,3,0,0,"DEAD~Helicase_C","NA","cellular organisms","Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis"]
["YJL050W","MTR4",6322411,8,16,0,0,"DEAD~Helicase_C~DSHCT","NA","cellular organisms","Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA"]
["YJL051W","IRC8",6322410,8,3,0,0,"NA","NA","Saccharomycetaceae","Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc"]
["YJL124C","LSM1",6322337,8,25,0,0,"LSM","NA","cellular organisms","Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs"]
["YJL140W","RPB4",6322321,8,21,0,0,"RNA_pol_Rpb4~FYDLN_acid","NA","Eukaryota","RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions"]
["YJL190C","RPS22A",6322271,8,13,0,0,"Ribosomal_S8","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins"]
["YJR104C","SOD1",6322564,8,19,0,0,"Sod_Cu","1.15.1.1_Superoxide dismutase","cellular organisms","Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans"]
["YKL045W","PRI2",6322806,8,5,0,0,"DNA_primase_lrg","NA","Eukaryota","Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair"]
["YKL062W","MSN4",6322788,8,5,0,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"]
["YKL125W","RRN3",6322724,8,8,0,0,"RRN3","NA","Eukaryota","Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA"]
["YKR008W","RSC4",6322860,8,27,0,0,"Bromodomain~Bromodomain","NA","Fungi/Metazoa group","Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling"]
["YKR023W","YKR023W",6322875,8,13,1,0,"zf-C2HC5","NA","Ascomycota","NA"]
["YKR078W","YKR078W",6322931,8,24,0,0,"PX~Vps5","NA","Ascomycota","NA"]
["YLL024C","SSA2",6323004,8,14,0,0,"HSP70","NA","cellular organisms","ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall"]
["YLL038C","ENT4",6322990,8,15,0,0,"ENTH","NA","Eukaryota","Protein of unknown function, contains an N-terminal epsin-like domain"]
["YLL045C","RPL8B",6322984,8,7,0,0,"Ribosomal_L7Ae","NA","cellular organisms","Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"]
["YLL057C","JLP1",6322971,8,11,0,0,"TauD","NA","cellular organisms","Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)"]
["YLR007W","NSE1",6323035,8,2,0,0,"SMC_Nse1~zf-RING-like","NA","Fungi/Metazoa group","Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes"]
["YLR130C","ZRT2",6323159,8,6,0,0,"Zip","NA","Eukaryota","Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor"]
["YLR136C","TIS11",6323165,8,4,0,0,"zf-CCCH~zf-CCCH","NA","Eukaryota","mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis"]
["YLR148W","PEP3",6323177,8,24,0,0,"Pep3_Vps18~Clathrin","NA","Eukaryota","Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis"]
["YLR194C","YLR194C",6323223,8,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLR199C","PBA1",37362679,8,11,0,0,"POC4","NA","Saccharomycetaceae","Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly"]
["YLR200W","YKE2",6323229,8,18,0,0,"Prefoldin_2~BicD~DUF2046","NA","Eukaryota","Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin"]
["YLR206W","ENT2",6323235,8,6,0,0,"ENTH","NA","Eukaryota","Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus"]
["YLR248W","RCK2",6323277,8,12,0,0,"Pkinase~Kdo~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations"]
["YLR328W","NMA1",6323360,8,4,0,0,"CTP_transf_2","2.7.7.1_Nicotinamide-nucleotide adenylyltransferase","cellular organisms","Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways"]
["YLR362W","STE11",6323394,8,9,0,0,"SAM_2~SAM_1~Pkinase~Pkinase~Pkinase_Tyr","NA","cellular organisms","Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p"]
["YLR373C","VID22",6323405,8,22,0,0,"NA","NA","Saccharomycetaceae","Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles"]
["YLR407W","YLR407W",6323439,8,22,1,0,"NA","NA","Saccharomycetales","NA"]
["YLR438C-A","LSM3",6323471,8,7,0,0,"LSM","NA","cellular organisms","Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"]
["YLR442C","SIR3",6323475,8,5,0,0,"BAH","NA","Fungi/Metazoa group","Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p"]
["YML001W","YPT7",6323642,8,31,0,0,"ATP-synt_ab~Miro~NACHT~Ras","NA","cellular organisms","GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7"]
["YML067C","ERV41",6323573,8,12,0,0,"DUF1692","NA","Eukaryota","Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein"]
["YML071C","COG8",6323569,8,50,0,0,"Dor1","NA","Dikarya","Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YML107C","PML39",37362681,8,14,0,0,"NA","NA","Saccharomycetaceae","Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes"]
["YML114C","TAF8",6323522,8,5,0,0,"TAF8_C","NA","Ascomycota","TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation"]
["YML121W","GTR1",6323514,8,14,0,0,"Miro~Gtr1_RagA","NA","Eukaryota","Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB"]
["YMR014W","BUD22",6323656,8,6,0,0,"BUD22","NA","Dikarya","Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YMR081C","ISF1",6323727,8,17,0,0,"NA","NA","Saccharomyces cerevisiae","Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant"]
["YMR116C","ASC1",6323763,8,15,0,0,"WD40~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation"]
["YMR163C","INP2",6323815,8,3,0,0,"NA","NA","Saccharomycetaceae","Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene"]
["YMR167W","MLH1",6323819,8,11,0,0,"HATPase_c~DNA_mis_repair","NA","cellular organisms","Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer"]
["YMR230W","RPS10B",6323886,8,5,0,0,"S10_plectin","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10"]
["YMR236W","TAF9",6323892,8,6,0,0,"TFIID-31kDa","NA","Eukaryota","Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3"]
["YMR237W","BCH1",6323893,8,23,0,0,"ChAPs","NA","Eukaryota","Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes"]
["YMR244W","YMR244W",6323900,8,9,1,0,"SUN","NA","Eukaryota","NA"]
["YMR259C","YMR259C",6323915,8,7,1,0,"DUF2428","NA","Eukaryota","NA"]
["YMR273C","ZDS1",6323929,8,18,0,0,"DUF963~Zds1_C","NA","Saccharomycetales","Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export"]
["YMR317W","YMR317W",6323978,8,6,1,0,"NA","NA","cellular organisms","NA"]
["YNL010W","YNL010W",6324318,8,8,1,0,"NA","NA","cellular organisms","NA"]
["YNL012W","SPO1",9755342,8,7,0,0,"PLA2_B~PLA2_B~PLA2_B","NA","Dikarya","Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation"]
["YNL027W","CRZ1",6324301,8,18,0,0,"zf-C2H2~zf-C2H2","NA","Fungi/Metazoa group","Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation"]
["YNL079C","TPM1",6324250,8,25,0,0,"IFP_35_N","NA","Dikarya","Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently"]
["YNL210W","MER1",6324119,8,5,0,0,"KH_1","NA","Saccharomycetaceae","Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination"]
["YNL230C","ELA1",6324099,8,13,0,0,"Elongin_A~Elongin_A","NA","Ascomycota","Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex"]
["YNL289W","PCL1",6324040,8,12,0,0,"Cyclin_N~Cyclin","NA","Eukaryota","Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth"]
["YNL307C","MCK1",6324022,8,46,0,0,"Pkinase_Tyr~Pkinase~APH~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family"]
["YNL322C","KRE1",6324007,8,38,0,0,"NA","NA","Saccharomycetaceae","Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor"]
["YNR024W","YNR024W",6324351,8,8,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YNR028W","CPR8",6324355,8,13,0,0,"Pro_isomerase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway"]
["YNR046W","TRM112",6324374,8,3,0,0,"Trm112p","NA","Eukaryota","Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; putative zinc binding subunit of other MTase-related proteins"]
["YOL013C","HRD1",6324561,8,25,0,0,"zf-C3HC4","NA","Eukaryota","Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger"]
["YOL021C","DIS3",6324552,8,3,0,0,"OB_RNB~RNB","NA","cellular organisms","Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family"]
["YOL115W","PAP2",6324457,8,7,0,0,"NTP_transf_2~PAP_assoc","NA","cellular organisms","Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase"]
["YOL137W","BSC6",6324435,8,4,0,0,"MFS_1","NA","cellular organisms","Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"]
["YOR036W","PEP12",6324610,8,40,0,0,"SNARE","NA","Eukaryota","Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin"]
["YOR112W","CEX1",6324686,8,8,0,0,"NA","NA","Eukaryota","Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p"]
["YOR127W","RGA1",6324701,8,15,0,0,"LIM~RhoGAP","NA","Fungi/Metazoa group","GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth"]
["YOR194C","TOA1",6324768,8,21,0,0,"TFIIA","NA","Fungi/Metazoa group","TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA"]
["YOR209C","NPT1",6324783,8,9,0,0,"NAPRTase~DUF1313","2.4.2.11_Nicotinate phosphoribosyltransferase","cellular organisms","Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus"]
["YOR252W","TMA16",84626312,8,4,0,0,"NA","NA","Fungi/Metazoa group","Protein of unknown function that associates with ribosomes"]
["YOR274W","MOD5",6324848,8,16,0,0,"IPPT","2.5.1.8_tRNA isopentenyltransferase","cellular organisms","Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms"]
["YOR280C","FSH3",6324854,8,11,0,0,"FSH1","NA","Eukaryota","Serine hydrolase; sequence is similar to Fsh1p and Fsh2p"]
["YOR316C","COT1",6324892,8,7,0,0,"Cation_efflux~Cation_efflux","NA","cellular organisms","Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium"]
["YOR319W","HSH49",6324895,8,6,0,0,"RRM_1~RRM_1","NA","cellular organisms","U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)"]
["YOR340C","RPA43",6324916,8,16,0,0,"RNA_pol_Rpb7_N","NA","Eukaryota","RNA polymerase I subunit A43"]
["YOR349W","CIN1",6324925,8,17,0,0,"NA","NA","Ascomycota","Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl"]
["YOR365C","YOR365C",6324942,8,12,1,0,"TRP","NA","Dikarya","NA"]
["YOR372C","NDD1",6324948,8,5,0,0,"NA","NA","Saccharomycetaceae","Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes"]
["YPL015C","HST2",6325242,8,4,0,0,"SIR2","NA","cellular organisms","Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro"]
["YPL016W","SWI1",6325241,8,12,0,0,"ARID","NA","Ascomycota","Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can become prion [SWI+]"]
["YPL042C","SSN3",6325215,8,16,0,0,"Pkinase~Pkinase_Tyr","2.7.11.22_Cyclin-dependent kinase|2.7.11.23_[RNA-polymerase]-subunit kinase","cellular organisms","Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression"]
["YPL085W","SEC16",6325172,8,6,0,0,"NA","NA","Saccharomycetaceae","COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p"]
["YPL086C","ELP3",6325171,8,7,0,0,"Radical_SAM~Acetyltransf_1","2.3.1.48_Histone acetyltransferase","cellular organisms","Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin"]
["YPL090C","RPS6A",6325167,8,11,0,0,"Ribosomal_S6e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein"]
["YPL099C","AIM43",6325158,8,14,1,0,"NA","NA","Saccharomycetaceae","Protein of unknown function;non-tagged protein detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media"]
["YPL124W","SPC29",6325133,8,11,0,0,"NA","NA","Saccharomyces cerevisiae","Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication"]
["YPL141C","YPL141C",6325116,8,6,1,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","NA"]
["YPL155C","KIP2",6325102,8,17,0,0,"Kinesin","NA","Eukaryota","Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle"]
["YPR027C","YPR027C",6325284,8,9,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YPR031W","NTO1",6325288,8,11,0,0,"EPL1~PHD","NA","Eukaryota","Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3"]
["YPR032W","SRO7",6325289,8,25,0,0,"Lgl_C","NA","Eukaryota","Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor"]
["YPR111W","DBF20",6325368,8,3,0,0,"Pkinase~Pkinase_Tyr~Pkinase~Pkinase_C","NA","cellular organisms","Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis"]
["YPR115W","YPR115W",6325372,8,6,1,0,"PH","NA","Dikarya","Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"]
["YPR201W","ARR3",6325459,8,11,0,0,"SBF","NA","cellular organisms","Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite"]
["YDR116C","MRPL1",6320321,8,9,0,1,"Ribosomal_L1","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YDR322W","MRPL35",6320528,8,18,0,1,"PBP","NA","Fungi/Metazoa group","Mitochondrial ribosomal protein of the large subunit"]
["YDR347W","MRP1",6320554,8,11,0,1,"NA","NA","Dikarya","Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein"]
["YER077C","YER077C",6320921,8,6,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YFR011C","AIM13",14318533,8,18,1,1,"DUF1690","NA","Ascomycota","Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media"]
["YGR174C","CBP4",6321613,8,4,0,1,"CBP4","NA","Ascomycota","Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p"]
["YGR257C","MTM1",6321696,8,8,0,1,"Mito_carr~Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor"]
["YHR001W-A","QCR10",6321788,8,19,0,1,"QCR10","NA","Saccharomycetales","Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain"]
["YHR038W","RRF1",6321827,8,7,0,1,"RRF","NA","cellular organisms","Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria"]
["YKL029C","MAE1",6322823,8,11,0,1,"malic~Malic_M~Malic_M","1.1.1.38_Malate dehydrogenase (oxaloacetate-decarboxylating)","cellular organisms","Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids"]
["YLR281C","YLR281C",6323311,8,10,1,1,"RF-1","NA","cellular organisms","NA"]
["YLR390W","ECM19",6323422,8,5,0,1,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YMR023C","MSS1",6323665,8,9,0,1,"TrmE_N~MMR_HSR1~Miro~Ras~GTP_EFTU~DUF258","NA","cellular organisms","Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3"]
["YMR066W","SOV1",6323711,8,6,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial protein of unknown function"]
["YOL096C","COQ3",37362692,8,8,0,1,"PrmA~Methyltransf_11~Methyltransf_12","2.1.1.114_Hexaprenyldihydroxybenzoate methyltransferase","cellular organisms","O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex"]
["YPL271W","ATP15",6324984,8,4,0,1,"ATP-synt_Eps","NA","Fungi/Metazoa group","Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"]
["YAR003W","SWD1",6319320,7,24,0,0,"WD40","NA","cellular organisms","Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7"]
["YBL060W","YEL1",6319411,7,7,0,0,"Sec7","NA","Ascomycota","Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip"]
["YBL068W","PRS4",37362615,7,19,0,0,"Pribosyltran","2.7.6.1_Ribose-phosphate diphosphokinase","cellular organisms","5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"]
["YBR119W","MUD1",6319595,7,6,0,0,"RRM_1","NA","Fungi/Metazoa group","U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing"]
["YBR158W","AMN1",6319634,7,6,0,0,"NA","NA","cellular organisms","Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)"]
["YBR194W","AIM4",6319671,7,14,1,0,"NA","NA","Saccharomycetaceae","Protein proposed to be associated with the nuclear pore complex; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and a severe growth defect in minimal glycerol media"]
["YBR218C","PYC2",6319695,7,9,0,0,"CPSase_L_chain~ATP-grasp~CPSase_L_D2~Biotin_carb_C~HMGL-like~HMGL-like~PYC_OADA~Biotin_lipoyl","6.4.1.1_Pyruvate carboxylase","cellular organisms","Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"]
["YBR288C","APM3",6319765,7,26,0,0,"Adap_comp_sub","NA","Eukaryota","Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway"]
["YCL002C","YCL002C",37362626,7,8,1,0,"NA","NA","Saccharomycetales","NA"]
["YCR007C","YCR007C",6319852,7,3,1,0,"DUP","NA","Saccharomycetaceae","NA"]
["YCR033W","SNT1",10383795,7,27,0,0,"DUF348~Myb_DNA-binding~Myb_DNA-binding","NA","Saccharomycetales","Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein"]
["YDL002C","NHP10",6320202,7,13,0,0,"HMG_box~HMG_box","NA","Eukaryota","Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex"]
["YDL065C","PEX19",93117371,7,14,0,0,"Pex19","NA","Eukaryota","Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane"]
["YDL074C","BRE1",6320129,7,26,0,0,"BRE1~zf-C2H2","NA","Eukaryota","E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain"]
["YDL082W","RPL13A",6320121,7,2,0,0,"Ribosomal_L13e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein"]
["YDL101C","DUN1",6320102,7,16,0,0,"FHA~Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair"]
["YDL114W","YDL114W",6320089,7,6,1,0,"KR~adh_short~adh_short","NA","cellular organisms","NA"]
["YDL145C","COP1",6320056,7,6,0,0,"WD40~WD40~WD40~WD40~WD40~Coatomer_WDAD~COPI_C~COPI_C","NA","cellular organisms","Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway"]
["YDL223C","HBT1",6319978,7,3,0,0,"NA","NA","Saccharomyces cerevisiae","Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis"]
["YDL225W","SHS1",6319976,7,17,0,0,"Septin~Septin","NA","Eukaryota","One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis"]
["YDR060W","MAK21",6320265,7,8,0,0,"CBF","NA","Eukaryota","Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein"]
["YDR075W","PPH3",6320280,7,28,0,0,"Metallophos","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p"]
["YDR093W","DNF2",6320298,7,15,0,0,"E1-E2_ATPase~Hydrolase_3","3.6.3.1_Phospholipid-translocating ATPase","cellular organisms","Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase"]
["YDR101C","ARX1",6320306,7,3,0,0,"Peptidase_M24","NA","Eukaryota","Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex"]
["YDR141C","DOP1",6320345,7,12,0,0,"Dopey_N~Dopey_N","NA","Dikarya","Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YDR202C","RAV2",6320409,7,32,0,0,"NA","NA","Saccharomycetales","Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme"]
["YDR240C","SNU56",6320447,7,5,0,0,"NA","NA","Saccharomycetaceae","Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex"]
["YDR256C","CTA1",6320462,7,11,0,0,"Catalase~Catalase-rel","1.11.1.6_Catalase","cellular organisms","Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation"]
["YDR293C","SSD1",6320499,7,14,0,0,"RNB","NA","cellular organisms","Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence"]
["YDR295C","HDA2",6320501,7,21,0,0,"DivIC","NA","Saccharomycetales","Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance"]
["YDR353W","TRR1",6320560,7,7,0,0,"Pyr_redox_2~Pyr_redox","NA","cellular organisms","Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress"]
["YDR424C","DYN2",6320632,7,2,0,0,"Dynein_light","NA","Eukaryota","Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex"]
["YDR481C","PHO8",6320689,7,5,0,0,"Alk_phosphatase","3.1.3.1_Alkaline phosphatase","cellular organisms","Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides"]
["YEL003W","GIM4",154199604,7,24,0,0,"Prefoldin_2","NA","Eukaryota","Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it"]
["YEL029C","BUD16",6320806,7,11,0,0,"PfkB~Phos_pyr_kin","NA","cellular organisms","Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection"]
["YEL057C","YEL057C",6320778,7,9,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YER012W","PRE1",6320849,7,7,0,0,"Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle"]
["YER019C-A","SBH2",6320857,7,20,0,0,"Sec61_beta","NA","Eukaryota","Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p"]
["YER048C","CAJ1",6320888,7,21,0,0,"DnaJ","NA","cellular organisms","Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly"]
["YER049W","TPA1",6320890,7,4,0,0,"2OG-FeII_Oxy~Ofd1_CTDD","NA","Eukaryota","Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability"]
["YER051W","JHD1",6320892,7,5,0,0,"PHD","1.14.11.27_[Histone H3]-lysine-36 demethylase","Eukaryota","JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe"]
["YER052C","HOM3",6320893,7,9,0,0,"AA_kinase~ACT","2.7.2.4_Aspartate kinase","cellular organisms","Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"]
["YER117W","RPL23B",6320963,7,9,0,0,"Ribosomal_L14","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins"]
["YER123W","YCK3",7276233,7,17,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p"]
["YER140W","YER140W",6320988,7,10,1,0,"DUF747~DUF747","NA","Eukaryota","NA"]
["YER167W","BCK2",6321015,7,13,0,0,"NA","NA","Saccharomycetaceae","Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations"]
["YFL044C","OTU1",14318475,7,5,0,0,"OTU","NA","Eukaryota","Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family"]
["YGL003C","CDH1",6321435,7,9,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1"]
["YGL040C","HEM2",6321398,7,5,0,0,"ALAD","4.2.1.24_Porphobilinogen synthase","cellular organisms","Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus"]
["YGL060W","YBP2",6321378,7,8,0,0,"DUF1760","NA","Saccharomycetales","Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p"]
["YGL108C","YGL108C",6321330,7,9,1,0,"NA","NA","Ascomycota","NA"]
["YGL112C","TAF6",6321326,7,12,0,0,"TAF~DUF1546","NA","Eukaryota","Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4"]
["YGL175C","SAE2",6321263,7,20,0,0,"SAE2","NA","Saccharomycetaceae","Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents"]
["YGL223C","COG1",6321215,7,10,0,0,"Vps51","NA","Saccharomycetaceae","Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YGL244W","RTF1",6321193,7,18,0,0,"Plus-3","NA","Eukaryota","Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance"]
["YGR002C","SWC4",6321439,7,10,0,0,"Myb_DNA-binding","NA","Eukaryota","Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex"]
["YGR020C","VMA7",6321457,7,34,0,0,"ATP-synt_F","NA","cellular organisms","Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"]
["YGR122W","YGR122W",6321560,7,41,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGR125W","YGR125W",6321564,7,9,1,0,"Sulfate_transp~STAS~cNMP_binding","NA","cellular organisms","NA"]
["YGR152C","RSR1",6321591,7,4,0,0,"Miro~Ras","NA","cellular organisms","GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases"]
["YGR200C","ELP2",6321639,7,5,0,0,"WD40~WD40~WD40~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin"]
["YGR234W","YHB1",6321673,7,4,0,0,"Globin~FAD_binding_6","1.14.12.17_Nitric oxide dioxygenase","cellular organisms","Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses"]
["YHR005C","GPA1",6321792,7,6,0,0,"G-alpha~G-alpha","NA","Eukaryota","GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome"]
["YHR007C","ERG11",6321795,7,28,0,0,"p450","1.14.13.70_Sterol 14-demethylase","cellular organisms","Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family"]
["YHR014W","SPO13",6321802,7,6,0,0,"NA","NA","Saccharomyces","Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II"]
["YHR021W-A","ECM12",6321810,7,2,1,0,"NA","NA","Saccharomyces cerevisiae","Non-essential protein of unknown function"]
["YHR033W","YHR033W",6321822,7,6,1,0,"AA_kinase~PUA","NA","cellular organisms","NA"]
["YHR064C","SSZ1",37362658,7,21,0,0,"HSP70","NA","cellular organisms","Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP"]
["YHR171W","ATG7",6321965,7,10,0,0,"ThiF","NA","cellular organisms","Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation"]
["YHR186C","KOG1",6321980,7,15,0,0,"HEAT","NA","Eukaryota","Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors"]
["YIL002C","INP51",6322189,7,20,0,0,"Syja_N~Exo_endo_phos","NA","Eukaryota","Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth"]
["YIL130W","ASG1",6322061,7,11,0,0,"Zn_clus~Fungal_trans","NA","Eukaryota","Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins"]
["YIR022W","SEC11",6322213,7,3,0,0,"Peptidase_S24","NA","cellular organisms","18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum"]
["YIR039C","YPS6",6322230,7,6,0,0,"Asp~Asp","NA","Eukaryota","Putative GPI-anchored aspartic protease"]
["YJL085W","EXO70",6322375,7,12,0,0,"Exo70","NA","Eukaryota","Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"]
["YJL107C","YJL107C",6322354,7,12,1,0,"DUF1212","NA","Ascomycota","NA"]
["YJL123C","YJL123C",6322338,7,14,0,0,"DUF2413","NA","Ascomycota","Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is synthetically lethal with cdc13-1"]
["YJL146W","IDS2",6322315,7,10,0,0,"NA","NA","Saccharomycetaceae","Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation"]
["YJL154C","VPS35",6322307,7,64,0,0,"Vps35","NA","Eukaryota","Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval"]
["YJL194W","CDC6",6322266,7,2,0,0,"ATP-synt_ab","NA","cellular organisms","Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p"]
["YJL207C","LAA1",6322254,7,26,0,0,"NA","NA","Dikarya","AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene"]
["YJR017C","ESS1",37362669,7,5,0,0,"WW~Rotamase","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain"]
["YJR040W","GEF1",6322500,7,40,0,0,"Voltage_CLC~CBS","NA","cellular organisms","Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates"]
["YJR055W","HIT1",6322515,7,12,0,0,"zf-HIT","NA","Fungi/Metazoa group","Protein of unknown function, required for growth at high temperature"]
["YJR060W","CBF1",6322520,7,11,0,0,"HLH","NA","Fungi/Metazoa group","Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA"]
["YJR090C","GRR1",6322549,7,13,0,0,"F-box","NA","cellular organisms","F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification"]
["YJR093C","FIP1",6322552,7,10,0,0,"Fip1","NA","Eukaryota","Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity"]
["YJR115W","YJR115W",6322575,7,10,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YKL014C","URB1",6322838,7,2,0,0,"NA","NA","Ascomycota","Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit"]
["YKL095W","YJU2",6322755,7,2,0,0,"DUF572","NA","Eukaryota","Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (\"nineteen complex\") and acts after Prp2p to promote the first catalytic reaction of splicing"]
["YKL156W","RPS27A",6322693,7,4,0,0,"Ribosomal_S27e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein"]
["YKL159C","RCN1",6322690,7,11,0,0,"Calcipressin","NA","Saccharomycetales","Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region"]
["YKL174C","TPO5",6322674,7,6,0,0,"AA_permease","NA","cellular organisms","Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles"]
["YKR004C","ECM9",37362672,7,2,0,0,"NA","NA","Ascomycota","Non-essential protein of unknown function"]
["YKR034W","DAL80",6322885,7,9,0,0,"GATA","NA","Fungi/Metazoa group","Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p"]
["YKR089C","TGL4",6322942,7,5,0,0,"Patatin","3.1.1.3_Triacylglycerol lipase","cellular organisms","Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate"]
["YKR098C","UBP11",6322951,7,7,0,0,"UCH","NA","Eukaryota","Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins"]
["YKR104W","YKR104W",6322957,7,5,0,0,"ABC_tran~MMR_HSR1~Miro","NA","cellular organisms","NA"]
["YLL051C","FRE6",6322977,7,6,0,0,"Ferric_reduct~FAD_binding_8~NAD_binding_6","NA","Eukaryota","Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels"]
["YLL052C","AQY2",6322976,7,5,0,0,"NA","NA","Ascomycota","Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains"]
["YLR010C","TEN1",6323038,7,2,0,0,"NA","NA","Saccharomycetaceae","Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p"]
["YLR083C","EMP70",6323112,7,8,0,0,"EMP70","NA","Eukaryota","Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions"]
["YLR150W","STM1",6323179,7,25,0,0,"Stm1_N","NA","Eukaryota","Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations"]
["YLR291C","GCD7",6323322,7,7,0,0,"IF-2B","NA","cellular organisms","Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"]
["YLR364W","GRX8",6323396,7,3,1,0,"NA","NA","Eukaryota","Putative cytosolic dithiol glutaredoxin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene that is strongly induced by arsenic"]
["YLR378C","SEC61",6323411,7,12,0,0,"Plug_translocon","NA","cellular organisms","Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER"]
["YLR451W","LEU3",6323484,7,10,0,0,"Zn_clus","NA","Ascomycota","Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis"]
["YML022W","APT1",6323619,7,13,0,0,"Pribosyltran","2.4.2.7_Adenine phosphoribosyltransferase","cellular organisms","Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis"]
["YML048W","GSF2",6323593,7,25,0,0,"NA","NA","Saccharomycetales","ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression"]
["YML069W","POB3",6323571,7,5,0,0,"SSrecog~Rtt106","NA","Eukaryota","Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)"]
["YML080W","DUS1",6323560,7,10,0,0,"Dus","NA","cellular organisms","Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17"]
["YMR012W","CLU1",6323654,7,3,0,0,"NA","NA","Eukaryota","eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant"]
["YMR079W","SEC14",6323725,7,6,0,0,"CRAL_TRIO_N~CRAL_TRIO","NA","Eukaryota","Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs"]
["YMR086W","YMR086W",6323732,7,7,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR197C","VTI1",6323853,7,3,0,0,"Nsp1_C~V-SNARE","NA","Eukaryota","Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways"]
["YMR220W","ERG8",6323876,7,13,0,0,"GHMP_kinases_N~GHMP_kinases_C","2.7.4.2_Phosphomevalonate kinase","cellular organisms","Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate"]
["YMR281W","GPI12",6323937,7,2,0,0,"PIG-L","NA","Eukaryota","ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp"]
["YMR300C","ADE4",6323958,7,4,0,0,"GATase_2~Pribosyltran","2.4.2.14_Amidophosphoribosyltransferase","cellular organisms","Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway"]
["YNL042W","BOP3",6324286,7,3,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury"]
["YNL062C","GCD10",6324267,7,7,0,0,"Gcd10p","NA","Eukaryota","Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression"]
["YNL123W","NMA111",6324206,7,8,0,0,"PDZ","NA","cellular organisms","Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases"]
["YNL148C","ALF1",6324181,7,14,0,0,"CAP_GLY","NA","Eukaryota","Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance"]
["YNL202W","SPS19",99030931,7,5,0,0,"adh_short","NA","cellular organisms","Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate"]
["YNL215W","IES2",6324114,7,8,0,0,"DUF874~PAPA-1","NA","Saccharomycetales","Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions"]
["YNL225C","CNM67",6324104,7,12,0,0,"NA","NA","Saccharomycetaceae","Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration"]
["YNL246W","VPS75",6324083,7,7,0,0,"NA","NA","Eukaryota","NAP family histone chaperone; binds to histone H3-H4 tetramers and to histone acetyltransferase RTT109; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting"]
["YNL259C","ATX1",6324070,7,14,0,0,"HMA","NA","Eukaryota","Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake"]
["YNR011C","PRP2",6324338,7,2,0,0,"Helicase_C~HA2~DUF1605","NA","cellular organisms","RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing"]
["YOL005C","RPB11",6324569,7,7,0,0,"RNA_pol_L","NA","cellular organisms","RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit"]
["YOL019W","YOL019W",6324554,7,4,1,0,"PalI","NA","Ascomycota","NA"]
["YOL057W","YOL057W",6324515,7,8,0,0,"Peptidase_M49","3.4.14.4_Dipeptidyl-peptidase III","cellular organisms","NA"]
["YOL062C","APM4",6324510,7,13,0,0,"Adap_comp_sub","NA","Eukaryota","Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport"]
["YOL063C","CRT10",6324509,7,13,0,0,"CRT10","NA","Saccharomycetaceae","Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat"]
["YOL138C","YOL138C",6324434,7,7,0,0,"WD40~WD40~zf-C3HC4","NA","Eukaryota","Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity"]
["YOR038C","HIR2",6324612,7,20,0,0,"Hira","NA","Eukaryota","Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p"]
["YOR058C","ASE1",14318440,7,6,0,0,"MAP65_ASE1","NA","Eukaryota","Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate"]
["YOR086C","TCB1",6324660,7,5,0,0,"C2~C2~C2","NA","Eukaryota","Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact"]
["YOR195W","SLK19",6324769,7,11,0,0,"NA","NA","Saccharomycetaceae","Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate"]
["YOR216C","RUD3",6324790,7,27,0,0,"GRAB","NA","Dikarya","Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1"]
["YOR231W","MKK1",6324805,7,9,0,0,"Pkinase~Pkinase_Tyr","2.7.12.2_Mitogen-activated protein kinase kinase","cellular organisms","Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p"]
["YOR233W","KIN4",6324807,7,8,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck"]
["YOR247W","SRL1",6324821,7,10,0,0,"NA","NA","Saccharomycetaceae","Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants"]
["YOR265W","RBL2",6324839,7,7,0,0,"TBCA","NA","Eukaryota","Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A"]
["YOR270C","VPH1",6324844,7,7,0,0,"V_ATPase_I","NA","cellular organisms","Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes"]
["YOR291W","YOR291W",6324865,7,9,1,0,"E1-E2_ATPase~Hydrolase","NA","cellular organisms","NA"]
["YOR312C","RPL20B",154200011,7,10,0,0,"Ribosomal_L18ae","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein"]
["YOR335C","ALA1",6324911,7,5,0,0,"tRNA-synt_2c~tRNA_SAD~DHHA1","6.1.1.7_Alanine--tRNA ligase","cellular organisms","Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog"]
["YOR351C","MEK1",6324927,7,3,0,0,"FHA~Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids"]
["YPL133C","RDS2",6325124,7,12,0,0,"Zn_clus","NA","Dikarya","Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole"]
["YPL190C","NAB3",6325066,7,13,0,0,"RRM_1","NA","Fungi/Metazoa group","Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p"]
["YPL259C","APM1",6324996,7,31,0,0,"Clat_adaptor_s~Adap_comp_sub","NA","Eukaryota","Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting"]
["YPR026W","ATH1",6325283,7,5,0,0,"Glyco_hydro_65N~Glyco_hydro_65m~Glyco_hydro_65C","3.2.1.28_Alpha,alpha-trehalase","cellular organisms","Acid trehalase required for utilization of extracellular trehalose"]
["YPR062W","FCY1",6325319,7,8,0,0,"dCMP_cyt_deam_1","3.5.4.1_Cytosine deaminase","cellular organisms","Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)"]
["YPR066W","UBA3",6325323,7,11,0,0,"ThiF~UBA_e1_thiolCys~UBACT","NA","cellular organisms","Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YPR089W","YPR089W",37362705,7,15,1,0,"NA","NA","Dikarya","NA"]
["YPR159W","KRE6",6325417,7,8,0,0,"SKN1","NA","cellular organisms","Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p"]
["YPR199C","ARR1",6325457,7,8,0,0,"bZIP_1","NA","Saccharomycetaceae","Transcriptional activator of the bZIP family, required for transcription of genes involved in resistance to arsenic compounds"]
["YDR178W","SDH4",6320383,7,9,0,1,"CybS","NA","Dikarya","Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone"]
["YEL006W","YEA6",6320831,7,11,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog"]
["YGR012W","YGR012W",6321449,7,12,0,1,"PALP","2.5.1.47_Cysteine synthase","cellular organisms","NA"]
["YIL042C","PKP1",6322147,7,5,0,1,"BCDHK_Adom3~HATPase_c","2.7.11.2_[Pyruvate dehydrogenase (acetyl-transferring)] kinase","cellular organisms","Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p"]
["YIL051C","MMF1",6322138,7,18,0,1,"Ribonuc_L-PSP","NA","cellular organisms","Mitochondrial protein involved in maintenance of the mitochondrial genome"]
["YJL102W","MEF2",6322359,7,23,0,1,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~EFG_C~EFG_C","NA","cellular organisms","Mitochondrial elongation factor involved in translational elongation"]
["YJR122W","IBA57",6322582,7,12,0,1,"GCV_T_C","NA","cellular organisms","Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system"]
["YLR059C","REX2",6323088,7,12,0,1,"Exonuc_X-T","NA","cellular organisms","RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases"]
["YML091C","RPM2",6323548,7,2,0,1,"RPM2","3.1.26.5_Ribonuclease P","Saccharomycetales","Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus"]
["YNR041C","COQ2",6324370,7,10,0,1,"UbiA","NA","cellular organisms","Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis"]
["YOR065W","CYT1",6324639,7,12,0,1,"Cytochrom_C1","NA","cellular organisms","Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex"]
["YAL061W","BDH2",6319257,6,6,1,0,"ADH_N~ADH_zinc_N","NA","cellular organisms","Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene"]
["YBL049W","MOH1",6319422,6,11,0,0,"Yippee","NA","Eukaryota","Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase"]
["YBL076C","ILS1",6319395,6,3,0,0,"tRNA-synt_1~tRNA-synt_1g~Anticodon_1","6.1.1.5_Isoleucine--tRNA ligase","cellular organisms","Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A"]
["YBL091C-A","SCS22",41629673,6,12,0,0,"Motile_Sperm","NA","Eukaryota","Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein"]
["YBL106C","SRO77",6319362,6,5,0,0,"Lgl_C","NA","Eukaryota","Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p"]
["YBR007C","DSF2",6319479,6,17,1,0,"Sel1","NA","Saccharomycetaceae","Deletion suppressor of mpt5 mutation"]
["YBR048W","RPS11B",6319522,6,8,0,0,"Ribosomal_S17","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins"]
["YBR133C","HSL7",6319610,6,8,0,0,"PRMT5","2.1.1.125_Histone-arginine N-methyltransferase","Eukaryota","Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p"]
["YBR138C","YBR138C",6319614,6,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBR156C","SLI15",6319632,6,16,0,0,"INCENP_ARK-bind","NA","Saccharomycetaceae","Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase"]
["YBR173C","UMP1",6319650,6,13,0,0,"UMP1","NA","Fungi/Metazoa group","Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly"]
["YBR195C","MSI1",6319672,6,6,0,0,"WD40~WD40","NA","cellular organisms","Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46"]
["YBR285W","YBR285W",6319762,6,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YCR037C","PHO87",10383798,6,8,0,0,"SPX~CitMHS","NA","cellular organisms","Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments"]
["YDL047W","SIT4",6320156,6,7,0,0,"Metallophos","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization"]
["YDL100C","GET3",6320103,6,24,0,0,"ArsA_ATPase~CbiA","3.6.3.16_Arsenite-transporting ATPase","cellular organisms","Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking; has low-level ATPase activity and is involved in resistance to heat and metal stress"]
["YDL170W","UGA3",6320031,6,9,0,0,"Zn_clus","NA","Ascomycota","Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus"]
["YDL189W","RBS1",9755328,6,5,0,0,"R3H","NA","Fungi/Metazoa group","Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain"]
["YDL200C","MGT1",93117370,6,3,0,0,"Methyltransf_1N~DNA_binding_1","2.1.1.63_Methylated-DNA--[protein]-cysteine S-methyltransferase","cellular organisms","DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage"]
["YDL224C","WHI4",6319977,6,5,0,0,"RRM_1","NA","Ascomycota","Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division"]
["YDR042C","YDR042C",6320247,6,7,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDR067C","OCA6",6320272,6,17,1,0,"Y_phosphatase2~DSPc","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"]
["YDR098C","GRX3",6320303,6,10,0,0,"Thioredoxin~Glutaredoxin","NA","cellular organisms","Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage"]
["YDR123C","INO2",6320328,6,12,0,0,"NA","NA","Saccharomycetaceae","Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion"]
["YDR131C","YDR131C",6320336,6,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR171W","HSP42",6320376,6,2,0,0,"HSP20","NA","cellular organisms","Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock"]
["YDR173C","ARG82",6320378,6,19,0,0,"IPK","2.7.1.151_Inositol-polyphosphate multikinase","Eukaryota","Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes"]
["YDR177W","UBC1",6320382,6,6,0,0,"UQ_con~UBA_3","6.3.2.19_Ubiquitin--protein ligase","Eukaryota","Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response"]
["YDR190C","RVB1",6320396,6,4,0,0,"CPT~AAA~TIP49","NA","cellular organisms","Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family"]
["YDR226W","ADK1",6320432,6,15,0,0,"ADK~ADK_lid","2.7.4.3_Adenylate kinase","cellular organisms","Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence"]
["YDR244W","PEX5",6320450,6,12,0,0,"TPR_1~TPR_1~TPR_2","NA","cellular organisms","Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions"]
["YDR257C","SET7",6320463,6,24,0,0,"SET","NA","Eukaryota","Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins"]
["YDR313C","PIB1",6320519,6,12,0,0,"FYVE~zf-C3HC4","NA","Eukaryota","RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain"]
["YDR324C","UTP4",6320531,6,10,0,0,"NA","NA","cellular organisms","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YDR388W","RVS167",6320596,6,18,0,0,"BAR~SH3_1","NA","Eukaryota","Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin"]
["YDR406W","PDR15",6320614,6,13,0,0,"ABC_tran~ABC2_membrane~PDR_CDR~ABC_tran~ABC2_membrane","NA","cellular organisms","Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element"]
["YDR422C","SIP1",93117373,6,9,0,0,"AMPKBI","NA","Saccharomycetales","Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions"]
["YDR468C","TLG1",6320676,6,5,0,0,"SNARE","NA","Eukaryota","Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p"]
["YDR539W","YDR539W",6320748,6,3,1,0,"UbiD","NA","cellular organisms","NA"]
["YEL058W","PCM1",6320777,6,3,0,0,"PGM_PMM_I","5.4.2.3_Phosphoacetylglucosamine mutase","cellular organisms","Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors"]
["YEL066W","HPA3",6320768,6,6,0,0,"Acetyltransf_1","NA","cellular organisms","D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro"]
["YER007W","PAC2",6320843,6,35,0,0,"CAP_GLY","NA","cellular organisms","Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl"]
["YER088C","DOT6",6320933,6,16,0,0,"Myb_DNA-binding","NA","Saccharomycetaceae","Protein of unknown function, involved in telomeric gene silencing and filamentation"]
["YER132C","PMD1",6320979,6,2,0,0,"Kelch_1~Kelch_1","NA","Saccharomycetales","Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions"]
["YER148W","SPT15",6320996,6,8,0,0,"TBP~TBP","NA","cellular organisms","TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability"]
["YFL001W","DEG1",14318522,6,8,0,0,"PseudoU_synth_1~PseudoU_synth_1","NA","cellular organisms","Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm"]
["YFL005W","SEC4",14318517,6,12,0,0,"Miro~Ras","NA","cellular organisms","Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane"]
["YFL041W","FET5",14318477,6,8,0,0,"Cu-oxidase_3~Cu-oxidase~Cu-oxidase_2","NA","cellular organisms","Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport"]
["YFR021W","ATG18",16740527,6,13,0,0,"WD40","NA","cellular organisms","Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein"]
["YGL009C","LEU1",6321429,6,3,0,0,"Aconitase~Aconitase_C","4.2.1.33_3-isopropylmalate dehydratase","cellular organisms","Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway"]
["YGL011C","SCL1",6321427,6,9,0,0,"Proteasome_A_N~Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Alpha 1 subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria"]
["YGL017W","ATE1",6321421,6,3,0,0,"ATE_N~ATE_C","2.3.2.8_Arginyltransferase","cellular organisms","Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway"]
["YGL028C","SCW11",6321410,6,3,0,0,"NA","NA","cellular organisms","Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p"]
["YGL043W","DST1",6321395,6,19,0,0,"TFIIS~TFIIS_M~TFIIS_C","NA","Eukaryota","General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites"]
["YGL049C","TIF4632",6321389,6,8,0,0,"MIF4G","NA","Eukaryota","Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p"]
["YGL053W","PRM8",6321385,6,5,0,0,"DUP","NA","Saccharomycetaceae","Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family"]
["YGL077C","HNM1",6321361,6,16,0,0,"NA","NA","cellular organisms","Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol"]
["YGL155W","CDC43",6321283,6,2,0,0,"Prenyltrans~Prenyltrans~Prenyltrans~Prenyltrans","NA","Eukaryota","Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis"]
["YGL202W","ARO8",6321236,6,3,0,0,"NA","2.6.1.57_Aromatic-amino-acid transaminase","cellular organisms","Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis"]
["YGL215W","CLG1",6321223,6,9,0,0,"NA","NA","Ascomycota","Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2"]
["YGL231C","YGL231C",6321206,6,16,1,0,"DUF1077","NA","Eukaryota","NA"]
["YGL233W","SEC15",6321204,6,3,0,0,"Sec15","NA","Eukaryota","Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles"]
["YGR032W","GSC2",6321469,6,3,0,0,"Glucan_synthase","2.4.1.34_1,3-beta-glucan synthase","Eukaryota","Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)"]
["YGR072W","UPF3",6321509,6,7,0,0,"Smg4_UPF3","NA","Saccharomycetaceae","Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance"]
["YGR119C","NUP57",6321557,6,4,0,0,"NA","NA","cellular organisms","Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p"]
["YGR126W","YGR126W",6321565,6,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGR156W","PTI1",6321595,6,8,0,0,"NA","NA","Saccharomycetales","Pta1p Interacting protein"]
["YGR163W","GTR2",6321602,6,14,0,0,"Gtr1_RagA","NA","Eukaryota","Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD"]
["YGR212W","SLI1",6321651,6,5,0,0,"AATase~AATase","NA","Saccharomycetaceae","N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin"]
["YGR292W","MAL12",6321731,6,4,0,0,"Alpha-amylase","NA","cellular organisms","Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus"]
["YHL035C","VMR1",6321752,6,14,0,0,"ABC_membrane~ABC_tran~ABC_membrane~ABC_tran~MMR_HSR1","NA","cellular organisms","Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies"]
["YHR012W","VPS29",6321800,6,50,0,0,"NA","NA","cellular organisms","Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval"]
["YHR112C","YHR112C",6321904,6,14,1,0,"Cys_Met_Meta_PP~Aminotran_5~Cys_Met_Meta_PP~Cys_Met_Meta_PP","NA","cellular organisms","NA"]
["YHR156C","LIN1",6321950,6,31,0,0,"GYF","NA","Fungi/Metazoa group","Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication"]
["YHR158C","KEL1",6321952,6,6,0,0,"Kelch_1~Kelch_1~Kelch_1~Kelch_2","NA","Eukaryota","Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate"]
["YHR159W","YHR159W",6321953,6,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YIL009W","FAA3",6322182,6,16,0,0,"AMP-binding~AMP-binding","6.2.1.3_Long-chain-fatty-acid--CoA ligase","cellular organisms","Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"]
["YIL068C","SEC6",6322121,6,10,0,0,"Sec6","NA","Eukaryota","Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly"]
["YIL083C","YIL083C",6322108,6,15,1,0,"DFP","NA","cellular organisms","NA"]
["YIL088C","AVT7",6322103,6,8,0,0,"Aa_trans","NA","Eukaryota","Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"]
["YIL118W","RHO3",6322073,6,10,0,0,"Miro~Ras","NA","cellular organisms","Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p"]
["YIL121W","QDR2",6322070,6,13,0,0,"MFS_1","NA","cellular organisms","Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake"]
["YIR007W","YIR007W",6322197,6,6,1,0,"Cellulase","NA","cellular organisms","NA"]
["YIR026C","YVH1",6322217,6,9,0,0,"DSPc","3.1.3.48_Protein-tyrosine-phosphatase","Eukaryota","Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases"]
["YIR031C","DAL7",6322222,6,6,0,0,"Malate_synthase","2.3.3.9_Malate synthase","cellular organisms","Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"]
["YJL218W","YJL218W",6322243,6,9,1,0,"Hexapep","NA","cellular organisms","NA"]
["YJR002W","MPP10",6322461,6,3,0,0,"Mpp10","NA","Eukaryota","Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p"]
["YJR021C","REC107",6322481,6,5,0,0,"Mer2","NA","Saccharomycetaceae","Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation"]
["YJR050W","ISY1",6322510,6,10,0,0,"Isy1","NA","Eukaryota","Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest"]
["YJR079W","YJR079W",6322539,6,2,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YJR105W","ADO1",6322565,6,12,0,0,"PfkB","2.7.1.20_Adenosine kinase","cellular organisms","Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle"]
["YKL039W","PTM1",83722565,6,16,0,0,"Lung_7-TM_R","NA","Eukaryota","Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p"]
["YKL086W","SRX1",6322764,6,6,0,0,"ParBc","1.8.98.2_Sulfiredoxin","cellular organisms","Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes"]
["YKL098W","YKL098W",6322751,6,9,0,0,"NA","NA","Ascomycota","Putative protein of unknown function; YKL098W is synthetically sick with cdc13-1"]
["YKL121W","YKL121W",6322728,6,30,1,0,"WD40~WD40~WD40","NA","cellular organisms","NA"]
["YKL122C","SRP21",6322727,6,3,0,0,"NA","NA","Saccharomycetales","Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm"]
["YKL164C","PIR1",6322684,6,10,0,0,"PIR~PIR~PIR~PIR~PIR~PIR~PIR~PIR","NA","cellular organisms","O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle"]
["YKL176C","LST4",6322672,6,22,0,0,"NA","NA","Saccharomycetales","Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface"]
["YKL207W","LRC3",99030926,6,26,1,0,"DUF850","NA","Eukaryota","Putative protein of unknown function; non-essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YKR019C","IRS4",6322871,6,77,0,0,"NA","NA","Ascomycota","EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"]
["YKR021W","ALY1",6322873,6,12,0,0,"NA","NA","Dikarya","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"]
["YKR041W","YKR041W",6322893,6,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKR055W","RHO4",6322908,6,12,0,0,"Miro~Ras","NA","cellular organisms","Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity"]
["YKR057W","RPS21A",6322910,6,4,0,0,"Ribosomal_S21e","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein"]
["YKR062W","TFA2",6322915,6,5,0,0,"TFIIE_beta","NA","Eukaryota","TFIIE small subunit, involved in RNA polymerase II transcription initiation"]
["YLL018C-A","COX19",6323010,6,5,0,0,"CHCH","NA","Eukaryota","Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase"]
["YLR014C","PPR1",6323042,6,10,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p"]
["YLR021W","IRC25",6323049,6,10,0,0,"chaperone_DMP","NA","Saccharomycetales","Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions"]
["YLR045C","STU2",6323074,6,5,0,0,"NA","NA","Eukaryota","Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p"]
["YLR049C","YLR049C",6323078,6,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLR057W","YLR057W",6323086,6,25,1,0,"Glyco_hydro_47~Glyco_hydro_47","NA","Fungi/Metazoa group","NA"]
["YLR085C","ARP6",6323114,6,38,0,0,"Actin","NA","cellular organisms","Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"]
["YLR086W","SMC4",6323115,6,5,0,0,"SMC_N~SMC_hinge~NEP","NA","cellular organisms","Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate"]
["YLR097C","HRT3",6323126,6,2,0,0,"F-box","NA","Eukaryota","Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies"]
["YLR099C","ICT1",6323128,6,10,0,0,"Abhydrolase_1~Esterase~Abhydrolase_1","NA","cellular organisms","Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress"]
["YLR113W","HOG1",6323142,6,29,0,0,"Pkinase~Pkinase_Tyr","2.7.11.24_Mitogen-activated protein kinase","cellular organisms","Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p"]
["YLR126C","YLR126C",6323155,6,5,1,0,"GATase","NA","cellular organisms","NA"]
["YLR133W","CKI1",6323162,6,6,0,0,"Choline_kin_N~Choline_kinase~APH","2.7.1.32_Choline kinase","Eukaryota","Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway"]
["YLR170C","APS1",6323200,6,36,0,0,"Clat_adaptor_s","NA","Eukaryota","Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex"]
["YLR244C","MAP1",6323273,6,5,0,0,"Peptidase_M24","NA","cellular organisms","Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p"]
["YLR265C","NEJ1",6323295,6,12,0,0,"XLF","NA","Saccharomyces","Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p"]
["YLR292C","SEC72",6323323,6,24,0,0,"TPR_1~TPR_2","NA","Dikarya","Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"]
["YLR303W","MET17",6323333,6,5,0,0,"Cys_Met_Meta_PP~Aminotran_1_2~Aminotran_5","NA","cellular organisms","Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis"]
["YLR312C","QNQ1",6323343,6,14,1,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity"]
["YLR426W","YLR426W",6323458,6,12,1,0,"adh_short~KR~adh_short","NA","cellular organisms","NA"]
["YML019W","OST6",6323622,6,23,0,0,"OST3_OST6","2.4.1.119_Dolichyl-diphosphooligosaccharide--protein glycotransferase","Fungi/Metazoa group","Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p"]
["YML036W","CGI121",154199620,6,13,0,0,"CGI-121","NA","Eukaryota","Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121"]
["YML087C","AIM33",6323552,6,5,1,0,"FAD_binding_6~NAD_binding_1","NA","cellular organisms","Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YML103C","NUP188",6323533,6,23,0,0,"Nup188","NA","Dikarya","Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p"]
["YML113W","DAT1",6323523,6,20,0,0,"NA","NA","Saccharomyces cerevisiae","DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability"]
["YML119W","YML119W",6323516,6,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YML128C","MSC1",6323507,6,12,0,0,"Ish1~Ish1~Ish1","NA","Dikarya","Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated"]
["YMR026C","PEX12",6323668,6,12,0,0,"Pex2_Pex12","NA","Eukaryota","C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders"]
["YMR038C","CCS1",6323681,6,14,0,0,"HMA","NA","Eukaryota","Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation"]
["YMR041C","ARA2",6323684,6,4,0,0,"Aldo_ket_red","1.1.1.116_D-arabinose 1-dehydrogenase","cellular organisms","NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase"]
["YMR043W","MCM1",6323686,6,12,0,0,"SRF-TF","NA","Eukaryota","Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes"]
["YMR058W","FET3",6323703,6,23,0,0,"Cu-oxidase_2~Cu-oxidase_3~Cu-oxidase~Cu-oxidase_2","NA","cellular organisms","Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases"]
["YMR080C","NAM7",6323726,6,14,0,0,"UPF1_Zn_bind~ResIII","NA","cellular organisms","ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance"]
["YMR092C","AIP1",6323739,6,5,0,0,"WD40~WD40~WD40","NA","cellular organisms","Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats"]
["YMR117C","SPC24",6323764,6,9,0,0,"Spc24","NA","Ascomycota","Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"]
["YMR134W","ERG29",6323782,6,4,1,0,"NA","NA","Saccharomycetales","Protein that binds to and regulates Erg25p; localized to the ER; null mutant is viable in a respiratory defective background; synthetic lethal with mmt1 and mmt2 mutations; highly conserved in ascomycetes"]
["YMR156C","TPP1",6323806,6,15,0,0,"PNK3P","3.1.3.32_Polynucleotide 3'-phosphatase","Eukaryota","DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily"]
["YMR181C","YMR181C",6323835,6,13,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YMR205C","PFK2",6323861,6,11,0,0,"PFK~PFK~PFK","NA","cellular organisms","Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes"]
["YMR211W","DML1",6323867,6,7,0,0,"Tubulin","NA","Eukaryota","Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family"]
["YMR223W","UBP8",6323879,6,21,0,0,"zf-UBP~UCH","3.1.2.15_Ubiquitin thiolesterase","cellular organisms","Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B"]
["YMR235C","RNA1",6323891,6,6,0,0,"NA","NA","Eukaryota","GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport"]
["YMR269W","TMA23",44829555,6,8,0,0,"NA","NA","Fungi/Metazoa group","Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes"]
["YMR274C","RCE1",6323930,6,29,0,0,"Abi","NA","Eukaryota","Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone"]
["YMR289W","ABZ2",6323945,6,8,0,0,"Aminotran_4","4.1.3.38_Aminodeoxychorismate lyase","cellular organisms","Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis"]
["YMR290C","HAS1",6323947,6,6,0,0,"DEAD~Helicase_C","NA","cellular organisms","ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles"]
["YMR308C","PSE1",6323968,6,5,0,0,"HEAT~HEAT","NA","Eukaryota","Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p"]
["YMR312W","ELP6",6323972,6,8,0,0,"NA","NA","Ascomycota","Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity"]
["YNL254C","YNL254C",6324075,6,7,0,0,"NA","NA","Saccharomycetales","Hypothetical protein; null mutation suppresses cdc13-1 temperature sensitivity"]
["YNL298W","CLA4",6324031,6,19,0,0,"PH~PBD~Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p"]
["YNL325C","FIG4",6324005,6,26,0,0,"Syja_N","NA","Eukaryota","Polyphosphatidylinositol phosphatase involved in the metabolism of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2); required for efficient mating; physically associates with and regulated by Vac14p; contains a SAC1-like domain"]
["YNR021W","YNR021W",6324348,6,13,1,0,"DUF1682","NA","Ascomycota","NA"]
["YNR036C","YNR036C",6324364,6,6,0,0,"Ribosomal_S12","NA","cellular organisms","NA"]
["YOL047C","YOL047C",9755359,6,7,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOL105C","WSC3",6324467,6,14,0,0,"WSC~SKG6~Adeno_E3_CR2","NA","Eukaryota","Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis"]
["YOL121C","RPS19A",6324451,6,3,0,0,"Ribosomal_S19e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp"]
["YOL143C","RIB4",6324429,6,5,0,0,"DMRL_synthase","2.5.1.9_Riboflavin synthase","cellular organisms","Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin"]
["YOL159C","YOL159C",6324414,6,36,0,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YOR006C","TSR3",6324579,6,11,1,0,"RLI~DUF367","NA","cellular organisms","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Null mutant accumulates 20S pre-rRNA"]
["YOR033C","EXO1",6324607,6,10,0,0,"XPG_N~XPG_I","NA","cellular organisms","5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains"]
["YOR039W","CKB2",6324613,6,37,0,0,"CK_II_beta","NA","Eukaryota","Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases"]
["YOR101W","RAS1",6324675,6,10,0,0,"Miro~Ras","NA","cellular organisms","GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes"]
["YOR107W","RGS2",6324681,6,5,0,0,"RGS","NA","Fungi/Metazoa group","Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p"]
["YOR184W","SER1",6324758,6,14,0,0,"Aminotran_5","2.6.1.52_Phosphoserine transaminase","cellular organisms","3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p"]
["YOR186W","YOR186W",6324760,6,2,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YOR222W","ODC2",6324796,6,16,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism"]
["YOR243C","PUS7",6324817,6,16,0,0,"TruD~TruD","NA","cellular organisms","Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates"]
["YOR249C","APC5",6324823,6,5,0,0,"NA","NA","Ascomycota","Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"]
["YOR290C","SNF2",6324864,6,22,0,0,"QLQ~SNF2_N~Helicase_C~Bromodomain","NA","cellular organisms","Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p"]
["YOR302W","YOR302W",6324877,6,9,0,0,"Leader_CPA1","NA","Saccharomyces cerevisiae","NA"]
["YOR320C","GNT1",6324896,6,7,0,0,"Glyco_transf_8","NA","Ascomycota","N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus"]
["YOR329C","SCD5",6324905,6,5,0,0,"NA","NA","Saccharomycetales","Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1"]
["YOR358W","HAP5",6324934,6,12,0,0,"Histone~CBFD_NFYB_HMF","NA","Eukaryota","Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex"]
["YPL020C","ULP1",6325237,6,6,0,0,"Peptidase_C48","3.4.22.68_Ulp1 peptidase","Eukaryota","Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase"]
["YPL067C","YPL067C",6325190,6,7,1,0,"NA","NA","Ascomycota","NA"]
["YPL070W","MUK1",6325187,6,12,0,0,"VPS9","NA","Ascomycota","Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation"]
["YPL123C","RNY1",6325134,6,12,0,0,"Ribonuclease_T2~Ribonuclease_T2","3.1.27.1_Ribonuclease T(2)","Eukaryota","RNAse; member of the T(2) family of endoribonucleases"]
["YPL127C","HHO1",6325130,6,14,0,0,"Linker_histone~Linker_histone","NA","Fungi/Metazoa group","Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation"]
["YPL175W","SPT14",9755344,6,4,0,0,"PIGA~Glycos_transf_1","2.4.1.198_Phosphatidylinositol N-acetylglucosaminyltransferase","cellular organisms","UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins"]
["YPL178W","CBC2",6325079,6,8,0,0,"RRM_1","NA","cellular organisms","Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif"]
["YPL243W","SRP68",6325013,6,5,0,0,"NA","NA","Eukaryota","Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane"]
["YPR091C","YPR091C",6325349,6,18,0,0,"PH~DUF2404","NA","Eukaryota","NA"]
["YPR097W","YPR097W",6325354,6,4,0,0,"PX","NA","Dikarya","NA"]
["YPR121W","THI22",6325378,6,2,0,0,"Phos_pyr_kin~TENA_THI-4","NA","cellular organisms","Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis"]
["YPR132W","RPS23B",6325389,6,3,0,0,"Ribosomal_S12","NA","cellular organisms","Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"]
["YPR152C","URN1",6325410,6,13,0,0,"WW~FF","NA","Eukaryota","Pre-mRNA splicing factor associated with the U2-U5-U6 snRNPs, the RES complex, and the Prp19-associated complex (NTC); null mutation displays synthetic genetic interactions with mutations affecting U2 snRNA and pre-mRNA splicing factors"]
["YPR157W","YPR157W",6325415,6,6,1,0,"NA","NA","cellular organisms","NA"]
["YPR164W","MMS1",6325422,6,15,0,0,"MMS1","NA","Saccharomycetaceae","Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition"]
["YPR189W","SKI3",6325447,6,11,0,0,"TPR_1~TPR_2","NA","cellular organisms","Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses"]
["YBL013W","FMT1",41629674,6,20,0,1,"Formyl_trans_N~Formyl_trans_C","2.1.2.9_Methionyl-tRNA formyltransferase","cellular organisms","Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate"]
["YBR039W","ATP3",6319513,6,6,0,1,"ATP-synt","NA","cellular organisms","Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YBR185C","MBA1",6319662,6,15,0,1,"MBA1","NA","Saccharomycetales","Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane"]
["YCL009C","ILV6",6319837,6,5,0,1,"ACT~ALS_ss_C","NA","cellular organisms","Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria"]
["YDL033C","SLM3",6320172,6,15,0,1,"tRNA_Me_trans","NA","cellular organisms","tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)"]
["YDL048C","STP4",6320155,6,18,0,1,"zf-C2H2","NA","Saccharomycetales","Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p"]
["YER069W","ARG5,6",6320913,6,10,0,1,"AA_kinase~DUF619~Semialdhyde_dh","NA","cellular organisms","Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p"]
["YGL068W","MNP1",6321369,6,4,0,1,"Ribosomal_L12","NA","cellular organisms","Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth"]
["YGR046W","TAM41",6321483,6,9,0,1,"Mmp37","NA","Eukaryota","Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud"]
["YGR132C","PHB1",6321571,6,16,0,1,"Band_7","NA","cellular organisms","Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"]
["YHR106W","TRR2",6321898,6,5,0,1,"Pyr_redox_2~Pyr_redox","NA","cellular organisms","Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD"]
["YIL022W","TIM44",6322167,6,9,0,1,"Tim44","NA","Eukaryota","Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane"]
["YKL150W","MCR1",6322699,6,4,0,1,"FAD_binding_6~NAD_binding_1","1.6.2.2_Cytochrome-b5 reductase","cellular organisms","Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis"]
["YLR168C","AIM30",6323197,6,8,1,1,"PRELI","NA","Eukaryota","Putative protein of unknown function that may be involved in intramitochondrial sorting; similar to Ups1p and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growth"]
["YLR201C","COQ9",6323230,6,15,0,1,"COQ9","NA","Eukaryota","Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes"]
["YMR083W","ADH3",6323729,6,5,0,1,"ADH_N~ADH_zinc_N","1.1.1.1_Alcohol dehydrogenase","cellular organisms","Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production"]
["YMR252C","YMR252C",6323908,6,9,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YNL256W","FOL1",37362687,6,4,0,1,"FolB~FolB~FolB~HPPK~Pterin_bind~Pterin_bind","2.5.1.15_Dihydropteroate synthase|2.7.6.3_2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase|4.1.2.25_Dihydroneopterin aldolase","cellular organisms","Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities"]
["YOR226C","ISU2",6324800,6,8,0,1,"NifU_N","NA","cellular organisms","Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable"]
["YPL188W","POS5",6325068,6,19,0,1,"NAD_kinase","2.7.1.86_NADH kinase","cellular organisms","Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress"]
["YAL011W","SWC3",37362611,5,39,0,0,"NA","NA","Ascomycota","Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae"]
["YAL021C","CCR4",6319298,5,40,0,0,"Exo_endo_phos","3.1.13.4_Poly(A)-specific ribonuclease","cellular organisms","Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening"]
["YAL034C","FUN19",37362610,5,7,0,0,"SWIRM","NA","Ascomycota","Non-essential protein of unknown function"]
["YAR042W","SWH1",85666110,5,17,0,0,"Ank~Ank~PH~Oxysterol_BP","NA","Eukaryota","Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction"]
["YBL052C","SAS3",6319419,5,9,0,0,"MOZ_SAS","2.3.1.48_Histone acetyltransferase","Eukaryota","Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality"]
["YBL092W","RPL32",6319378,5,27,0,0,"Ribosomal_L32e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing"]
["YBL093C","ROX3",6319377,5,24,0,0,"Rox3","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme"]
["YBR042C","CST26",6319516,5,12,0,0,"Acyltransferase","NA","cellular organisms","Protein of unknown function, affects chromosome stability when overexpressed"]
["YBR129C","OPY1",6319605,5,4,0,0,"PH","NA","Saccharomycetaceae","Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YBR136W","MEC1",6319612,5,6,0,0,"UME~FAT~PI3_PI4_kinase~FATC","2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination"]
["YCL063W","VAC17",6319789,5,12,0,0,"NA","NA","Saccharomycetaceae","Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p"]
["YCR057C","PWP2",6319903,5,2,0,0,"WD40~WD40~WD40~WD40~WD40~PWP2","NA","cellular organisms","Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis"]
["YCR067C","SED4",6319912,5,12,0,0,"WD40","NA","Saccharomycetales","Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p"]
["YDL007W","RPT2",6320197,5,4,0,0,"AAA~AAA_3~AAA_5~Mg_chelatase","NA","cellular organisms","One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle"]
["YDL052C","SLC1",6320151,5,12,0,0,"Acyltransferase","2.3.1.51_1-acylglycerol-3-phosphate O-acyltransferase","cellular organisms","1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes"]
["YDL054C","MCH1",6320149,5,4,0,0,"MFS_1","NA","cellular organisms","Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"]
["YDL056W","MBP1",6320147,5,8,0,0,"KilA-N~Ank~Ank","NA","Dikarya","Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes"]
["YDL076C","RXT3",6320127,5,25,0,0,"Rxt3","NA","Ascomycota","Subunit of the RPD3L complex; involved in histone deacetylation"]
["YDL132W","CDC53",6320070,5,2,0,0,"Cullin~Cullin_Nedd8","NA","Eukaryota","Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation"]
["YDL135C","RDI1",6320066,5,10,0,0,"Rho_GDI","NA","Eukaryota","Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p"]
["YDL229W","SSB1",6319972,5,11,0,0,"HSP70","NA","cellular organisms","Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p"]
["YDR097C","MSH6",6320302,5,7,0,0,"MutS_I~MutS_II~MutS_III~MutS_IV~MutS_V","NA","cellular organisms","Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p"]
["YDR238C","SEC26",6320444,5,11,0,0,"Adaptin_N~Coatamer_beta_C","NA","Eukaryota","Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)"]
["YDR246W","TRS23",6320452,5,7,0,0,"Sybindin~Sybindin~Sybindin","NA","Eukaryota","One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4"]
["YDR282C","YDR282C",6320488,5,15,1,0,"DUF155","NA","cellular organisms","NA"]
["YDR285W","ZIP1",6320491,5,5,0,0,"NA","NA","Saccharomycetaceae","Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate"]
["YDR363W-A","SEM1",6320571,5,8,0,0,"DSS1_SEM1","NA","Ascomycota","Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1"]
["YDR384C","ATO3",6320592,5,5,0,0,"Grp1_Fun34_YaaH","NA","cellular organisms","Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters"]
["YDR403W","DIT1",6320611,5,9,0,0,"DIT1_PvcA","NA","cellular organisms","Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure"]
["YDR435C","PPM1",6320643,5,30,0,0,"LCM","NA","cellular organisms","Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits"]
["YDR466W","PKH3",6320674,5,10,0,0,"Pkinase~Pkinase_Tyr~APH","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant"]
["YDR494W","RSM28",27469362,5,9,0,0,"NA","NA","Saccharomycetaceae","Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation"]
["YDR504C","SPG3",6320712,5,2,0,0,"NA","NA","Saccharomyces cerevisiae","Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources"]
["YDR516C","EMI2",6320724,5,16,0,0,"Hexokinase_1~Hexokinase_2","2.7.1.2_Glucokinase","cellular organisms","Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p"]
["YEL040W","UTR2",6320795,5,4,0,0,"Glyco_hydro_16","NA","cellular organisms","Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance"]
["YER011W","TIR1",6320848,5,5,0,0,"SRP1_TIP1~PIR","NA","Eukaryota","Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking"]
["YER087W","AIM10",6320931,5,13,1,0,"tRNA-synt_2b","6.1.1.15_Proline--tRNA ligase","cellular organisms","Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation), severe growth defect in minimal glycerol media"]
["YFL011W","HXT10",14318510,5,6,0,0,"MFS_1~Sugar_tr~MFS_1","NA","cellular organisms","Putative hexose transporter, expressed at low levels and expression is repressed by glucose"]
["YFR026C","YFR026C",14318549,5,8,0,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YFR029W","PTR3",14318552,5,4,0,0,"PH","NA","Saccharomycetales","Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes"]
["YFR032C-A","RPL29",14318557,5,2,0,0,"Ribosomal_L29e","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate"]
["YFR037C","RSC8",14318562,5,26,0,0,"SWIRM~ZZ~Myb_DNA-binding","NA","Eukaryota","Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters"]
["YFR042W","KEG1",14318567,5,3,0,0,"NA","NA","Saccharomycetales","Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability"]
["YGL036W","YGL036W",6321402,5,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGL061C","DUO1",6321377,5,5,0,0,"DASH_Duo1","NA","Saccharomycetaceae","Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"]
["YGL086W","MAD1",6321352,5,8,0,0,"MAD","NA","Fungi/Metazoa group","Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p"]
["YGL133W","ITC1",6321305,5,20,0,0,"WAC_Acf1_DNA_bd~DDT","NA","Eukaryota","Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1"]
["YGL166W","CUP2",6321272,5,11,0,0,"Copper-fist","NA","Dikarya","Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations"]
["YGL227W","VID30",6321210,5,9,0,0,"SPRY~LisH","NA","Eukaryota","Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm"]
["YGL240W","DOC1",37362650,5,5,0,0,"APC10~F5_F8_type_C","NA","Eukaryota","Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis"]
["YGL250W","RMR1",37362648,5,11,0,0,"DUF2420","NA","Saccharomycetales","Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus"]
["YGL260W","YGL260W",6321177,5,4,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YGR041W","BUD9",6321478,5,4,0,0,"NA","NA","Saccharomyces cerevisiae","Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole"]
["YGR056W","RSC1",6321493,5,17,0,0,"Bromodomain~Bromodomain~BAH","NA","Fungi/Metazoa group","Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook"]
["YGR057C","LST7",37362653,5,33,0,0,"NA","NA","Fungi/Metazoa group","Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface"]
["YGR118W","RPS23A",6321556,5,8,0,0,"Ribosomal_S12","NA","cellular organisms","Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"]
["YGR121C","MEP1",6321559,5,4,0,0,"Ammonium_transp","NA","cellular organisms","Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation"]
["YGR143W","SKN1",6321582,5,14,0,0,"SKN1","NA","Eukaryota","Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p"]
["YGR195W","SKI6",6321634,5,5,0,0,"RNase_PH~RNase_PH_C","NA","cellular organisms","3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs"]
["YGR201C","YGR201C",37362656,5,3,1,0,"GST_C","NA","Eukaryota","NA"]
["YGR245C","SDA1",6321684,5,2,0,0,"NUC130_3NT~SDA1","NA","Eukaryota","Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis"]
["YGR246C","BRF1",6321685,5,3,0,0,"TFIIB_Zn_Ribbon~TFIIB~TFIIB~BRF1","NA","cellular organisms","TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB"]
["YGR285C","ZUO1",6321724,5,24,0,0,"DnaJ","NA","Eukaryota","Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p"]
["YHL010C","YHL010C",6321777,5,7,1,0,"BRAP2~zf-C3HC4~zf-UBP","NA","Eukaryota","Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences"]
["YHR078W","YHR078W",6321869,5,9,1,0,"NA","NA","Saccharomycetales","NA"]
["YHR109W","CTM1",6321901,5,10,0,0,"NA","2.1.1.59_[Cytochrome c]-lysine N-methyltransferase","Ascomycota","Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth"]
["YHR143W","DSE2",6321936,5,11,0,0,"NA","NA","Saccharomycetaceae","Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP"]
["YHR147C","MRPL6",6321941,5,12,0,0,"Ribosomal_L6~Ribosomal_L6","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit"]
["YHR194W","MDM31",6321988,5,11,0,0,"MDM31_MDM32","NA","Eukaryota","Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34"]
["YHR200W","RPN10",6321994,5,9,0,0,"NA","NA","Eukaryota","Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein"]
["YHR202W","YHR202W",6321996,5,9,1,0,"Metallophos","NA","cellular organisms","NA"]
["YIL004C","BET1",6322187,5,10,0,0,"SNARE","NA","Eukaryota","Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins"]
["YIL026C","IRR1",6322163,5,6,0,0,"NA","NA","Eukaryota","Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability"]
["YIL103W","DPH1",6322088,5,9,0,0,"Diphthamide_syn","NA","cellular organisms","Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p"]
["YIL105C","SLM1",6322086,5,37,0,0,"PH","NA","Dikarya","Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex"]
["YJL001W","PRE3",6322459,5,8,0,0,"Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides"]
["YJL039C","NUP192",6322421,5,2,0,0,"NA","NA","Dikarya","Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205"]
["YJL074C","SMC3",6322387,5,5,0,0,"SMC_N~SMC_hinge","NA","cellular organisms","Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member"]
["YJL158C","CIS3",6322303,5,16,0,0,"PIR","NA","Ascomycota","Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family"]
["YJL171C","YJL171C",6322290,5,6,0,0,"DUF2403~DUF2401","NA","cellular organisms","NA"]
["YJL185C","YJL185C",6322276,5,23,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YJL198W","PHO90",6322263,5,10,0,0,"SPX","NA","cellular organisms","Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"]
["YJL217W","YJL217W",6322244,5,11,0,0,"DUF1349","NA","cellular organisms","NA"]
["YJR014W","TMA22",6322474,5,4,0,0,"SUI1","NA","Eukaryota","Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1"]
["YJR047C","ANB1",6322507,5,3,0,0,"KOW~eIF-5a","NA","cellular organisms","Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions"]
["YJR058C","APS2",6322518,5,7,0,0,"Clat_adaptor_s","NA","Eukaryota","Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex"]
["YJR094C","IME1",6322553,5,6,0,0,"NA","NA","Saccharomyces cerevisiae","Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p"]
["YJR145C","RPS4A",6322605,5,9,0,0,"RS4NT~S4~Ribosomal_S4e~KOW","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein"]
["YKL002W","DID4",9755336,5,35,0,0,"Snf7","NA","Eukaryota","Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis"]
["YKL112W","ABF1",6322737,5,16,0,0,"BAF1_ABF1~BAF1_ABF1~BAF1_ABF1~BAF1_ABF1","NA","Saccharomycetaceae","DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair"]
["YKL129C","MYO3",6322720,5,5,0,0,"Myosin_head~Myosin_TH1~SH3_1~SH3_2","NA","Eukaryota","One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization"]
["YKL203C","TOR2",42759860,5,3,0,0,"HEAT~FAT~Rapamycin_bind~PI3_PI4_kinase~FATC","2.7.1.67_1-phosphatidylinositol 4-kinase|2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis"]
["YKL213C","DOA1",6322636,5,28,0,0,"WD40~WD40~WD40~WD40~WD40~PFU~PUL","NA","cellular organisms","WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase"]
["YKL216W","URA1",6322633,5,15,0,0,"DHO_dh","1.3.3.1_Dihydroorotate oxidase","cellular organisms","Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid"]
["YKR007W","MEH1",6322859,5,32,0,0,"NA","NA","Saccharomycetaceae","Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification"]
["YKR031C","SPO14",6322883,5,9,0,0,"PLDc~PLDc","NA","cellular organisms","Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis"]
["YKR074W","AIM29",6322927,5,8,1,0,"DUF2340","NA","Eukaryota","Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YKR077W","MSA2",6322930,5,7,0,0,"NA","NA","Saccharomyces cerevisiae","Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation"]
["YKR096W","YKR096W",6322949,5,10,0,0,"NA","NA","Ascomycota","NA"]
["YLL050C","COF1",6322978,5,2,0,0,"Cofilin_ADF","NA","Eukaryota","Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes"]
["YLR039C","RIC1",6323068,5,15,0,0,"NA","NA","Saccharomycetaceae","Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes"]
["YLR070C","XYL2",6323099,5,9,0,0,"ADH_N~ADH_zinc_N","1.1.1.9_D-xylulose reductase","cellular organisms","Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway"]
["YLR079W","SIC1",6323108,5,10,0,0,"NA","NA","Saccharomycetaceae","Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1"]
["YLR092W","SUL2",6323121,5,7,0,0,"Sulfate_transp","NA","cellular organisms","High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates"]
["YLR100W","ERG27",6323129,5,5,0,0,"NA","NA","cellular organisms","3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs"]
["YLR141W","RRN5",6323170,5,4,0,0,"NA","NA","Saccharomycetaceae","Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p"]
["YLR172C","DPH5",6323201,5,25,0,0,"TP_methylase","2.1.1.98_Diphthine synthase","cellular organisms","Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm"]
["YLR180W","SAM1",6323209,5,27,0,0,"S-AdoMet_synt_N~S-AdoMet_synt_M~S-AdoMet_synt_C","NA","cellular organisms","S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"]
["YLR246W","ERF2",6323275,5,7,0,0,"zf-DHHC","NA","Eukaryota","Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole"]
["YLR277C","YSH1",6323307,5,13,0,0,"Lactamase_B~RMMBL","NA","cellular organisms","Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs"]
["YLR337C","VRP1",6323370,5,25,0,0,"WH2","NA","Saccharomycetales","Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)"]
["YLR352W","YLR352W",6323384,5,5,1,0,"NA","NA","Ascomycota","NA"]
["YLR396C","VPS33",6323428,5,17,0,0,"Sec1","NA","Eukaryota","ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport"]
["YLR403W","SFP1",6323435,5,8,0,0,"zf-C2H2~zf-C2H2","NA","Ascomycota","Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation"]
["YLR424W","SPP382",6323456,5,4,0,0,"G-patch","NA","Fungi/Metazoa group","Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation"]
["YLR441C","RPS1A",6323474,5,7,0,0,"Ribosomal_S3Ae","NA","cellular organisms","Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein"]
["YML016C","PPZ1",6323625,5,24,0,0,"Metallophos","3.1.3.16_Phosphoprotein phosphatase","cellular organisms","Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance"]
["YML041C","VPS71",6323600,5,12,0,0,"NA","NA","Eukaryota","Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting"]
["YML062C","MFT1",6323578,5,13,0,0,"THOC7","NA","Saccharomycetaceae","Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance"]
["YML068W","ITT1",6323572,5,3,0,0,"IBR~IBR","NA","Eukaryota","Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins"]
["YMR071C","TVP18",6323716,5,29,0,0,"ICP","NA","Ascomycota","Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments"]
["YMR090W","YMR090W",6323737,5,2,1,0,"DapB_N~Semialdhyde_dh","NA","cellular organisms","NA"]
["YMR093W","UTP15",6323740,5,3,0,0,"WD40~WD40~U3_snoRNA_C","NA","cellular organisms","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YMR113W","FOL3",6323760,5,5,0,0,"NA","6.3.2.17_Tetrahydrofolate synthase","cellular organisms","Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis"]
["YMR114C","YMR114C",6323761,5,3,0,0,"DUF159","NA","cellular organisms","NA"]
["YMR126C","DLT1",6323774,5,16,1,0,"NA","NA","Saccharomycetales","Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)"]
["YMR176W","ECM5",6323830,5,6,0,0,"ARID~JmjC~PHD","NA","Fungi/Metazoa group","Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks"]
["YMR240C","CUS1",6323896,5,4,0,0,"DUF382~PSP","NA","Eukaryota","Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p"]
["YMR260C","TIF11",6323916,5,7,0,0,"eIF-1a","NA","cellular organisms","Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3"]
["YMR262W","YMR262W",6323918,5,9,1,0,"TatD_DNase","NA","cellular organisms","NA"]
["YMR304W","UBP15",6323962,5,11,0,0,"MATH~UCH","NA","Eukaryota","Ubiquitin-specific protease that may play a role in ubiquitin precursor processing"]
["YNL139C","RLR1",6324190,5,17,0,0,"NA","NA","Eukaryota","Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids"]
["YNL149C","PGA2",6324180,5,3,0,0,"PGA2~PGA2","NA","Ascomycota","Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect"]
["YNL164C","IBD2",6324165,5,5,0,0,"NA","NA","Saccharomycetaceae","Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p"]
["YNL173C","MDG1",6324156,5,2,0,0,"NA","NA","Saccharomycetaceae","Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations"]
["YNL187W","YNL187W",6324142,5,9,1,0,"NA","NA","Eukaryota","NA"]
["YNL267W","PIK1",6324062,5,43,0,0,"PI3Ka~PI3_PI4_kinase","2.7.1.67_1-phosphatidylinositol 4-kinase","Eukaryota","Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton"]
["YNR051C","BRE5",6324379,5,26,0,0,"NTF2~RRM_1","NA","Eukaryota","Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A"]
["YOL016C","CMK2",6324557,5,17,0,0,"Pkinase~Pkinase_Tyr","2.7.11.17_Calcium/calmodulin-dependent protein kinase","cellular organisms","Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II"]
["YOL069W","NUF2",6324503,5,7,0,0,"Nuf2","NA","Eukaryota","Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"]
["YOL117W","RRI2",6324455,5,6,0,0,"NA","NA","Saccharomycetaceae","Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response"]
["YOL135C","MED7",6324437,5,15,0,0,"MED7~MED7","NA","Eukaryota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YOR025W","HST3",6324599,5,11,0,0,"SIR2~SIR2","NA","cellular organisms","Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism"]
["YOR069W","VPS5",46562125,5,31,0,0,"PX~Vps5","NA","Eukaryota","Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p"]
["YOR079C","ATX2",6324653,5,8,0,0,"Zip","NA","Eukaryota","Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation"]
["YOR095C","RKI1",6324669,5,3,0,0,"Rib_5-P_isom_A","5.3.1.6_Ribose-5-phosphate isomerase","cellular organisms","Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis"]
["YOR117W","RPT5",6324691,5,11,0,0,"AAA~AAA_5~AAA_3~Mg_chelatase","NA","cellular organisms","One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription"]
["YOR118W","YOR118W",6324692,5,3,0,0,"TLD","NA","Ascomycota","Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity"]
["YOR143C","THI80",6324717,5,5,0,0,"TPK_catalytic~TPK_B1_binding","NA","Eukaryota","Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)"]
["YOR238W","YOR238W",37362697,5,8,1,0,"NA","NA","Eukaryota","NA"]
["YOR251C","YOR251C",6324825,5,5,0,0,"Rhodanese~Rhodanese","2.8.1.1_Thiosulfate sulfurtransferase","cellular organisms","NA"]
["YOR299W","BUD7",6324874,5,12,0,0,"ChAPs","NA","Eukaryota","Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"]
["YOR304W","ISW2",6324879,5,15,0,0,"SNF2_N~DEAD~Helicase_C~HAND~SLIDE","NA","cellular organisms","Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth"]
["YOR324C","FRT1",6324901,5,10,0,0,"NA","NA","Saccharomycetaceae","Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress"]
["YOR369C","RPS12",6324945,5,10,0,0,"Ribosomal_L7Ae","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12"]
["YPL003W","ULA1",6325254,5,20,0,0,"NA","NA","Eukaryota","Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation"]
["YPL027W","SMA1",6325230,5,5,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function involved in the assembly of the prospore membrane during sporulation"]
["YPL037C","EGD1",6325220,5,30,0,0,"NAC","NA","Eukaryota","Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b"]
["YPL064C","CWC27",6325193,5,5,0,0,"NA","NA","Eukaryota","Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p"]
["YPL077C","YPL077C",6325180,5,11,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL089C","RLM1",6325168,5,5,0,0,"SRF-TF","NA","Eukaryota","MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p"]
["YPL092W","SSU1",6325165,5,5,0,0,"C4dic_mal_tran","NA","cellular organisms","Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein"]
["YPL122C","TFB2",6325135,5,5,0,0,"Tfb2","NA","Eukaryota","Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH"]
["YPL145C","KES1",6325112,5,24,0,0,"Oxysterol_BP","NA","Eukaryota","Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex"]
["YPL161C","BEM4",6325096,5,18,0,0,"NA","NA","Saccharomycetaceae","Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length"]
["YPL181W","CTI6",6325075,5,23,0,0,"PHD","NA","Ascomycota","Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain"]
["YPL183C","RTT10",6325074,5,16,0,0,"WD40~WD40","NA","cellular organisms","Cytoplasmic protein with a role in regulation of Ty1 transposition"]
["YPL208W","RKM1",6325048,5,6,0,0,"SET","NA","Eukaryota","SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)"]
["YPL224C","MMT2",6325032,5,7,0,0,"Cation_efflux","NA","cellular organisms","Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p"]
["YPL235W","RVB2",6325021,5,2,0,0,"AAA~TIP49","NA","cellular organisms","Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family"]
["YPR007C","REC8",6325264,5,5,0,0,"Rad21_Rec8_N","NA","Saccharomycetaceae","Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p"]
["YPR010C","RPA135",6325267,5,7,0,0,"RNA_pol_Rpb2_1~RNA_pol_Rpb2_2~RNA_pol_Rpb2_3~RNA_pol_Rpa2_4~RNA_pol_Rpb2_5~RNA_pol_Rpb2_6~RNA_pol_Rpb2_7","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","RNA polymerase I subunit A135"]
["YPR018W","RLF2",6325275,5,10,0,0,"NA","NA","Fungi/Metazoa group","Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin"]
["YPR068C","HOS1",6325325,5,6,0,0,"Hist_deacetyl","3.5.1.98_Histone deacetylase","cellular organisms","Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex"]
["YPR072W","NOT5",6325329,5,7,0,0,"Not3~NOT2_3_5","NA","Eukaryota","Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation"]
["YPR084W","YPR084W",6325341,5,11,1,0,"Miro~Ras","NA","Saccharomycetales","NA"]
["YPR095C","SYT1",6325352,5,16,0,0,"Sec7","NA","Saccharomycetaceae","Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family"]
["YPR103W","PRE2",6325360,5,4,0,0,"Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome"]
["YPR118W","MRI1",6325375,5,3,0,0,"IF-2B","5.3.1.23_S-methyl-5-thioribose-1-phosphate isomerase","cellular organisms","Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway"]
["YPR179C","HDA3",6325437,5,23,0,0,"NA","NA","Ascomycota","Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p"]
["YDR197W","CBS2",6320403,5,10,0,1,"ApbA_C","NA","Ascomycota","Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"]
["YDR204W","COQ4",6320410,5,5,0,1,"Coq4","NA","cellular organisms","Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex"]
["YER086W","ILV1",6320930,5,31,0,1,"PALP~Thr_dehydrat_C~Thr_dehydrat_C","4.3.1.19_Threonine ammonia-lyase","cellular organisms","Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation"]
["YFL016C","MDJ1",14318504,5,12,0,1,"DnaJ~DnaJ_CXXCXGXG~DnaJ_C","NA","cellular organisms","Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones"]
["YFL027C","GYP8",16740526,5,8,0,1,"NA","NA","Eukaryota","GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport"]
["YFR024C-A","LSB3",15530184,5,3,0,1,"DUF500~SH3_1~SH3_2","NA","cellular organisms","Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"]
["YGL059W","PKP2",27808706,5,3,0,1,"BCDHK_Adom3~HATPase_c","NA","Eukaryota","Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p"]
["YGR193C","PDX1",6321632,5,10,0,1,"Biotin_lipoyl~E3_binding","NA","cellular organisms","Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core"]
["YHL021C","AIM17",6321766,5,15,1,1,"TauD","NA","cellular organisms","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)"]
["YJL161W","FMP33",6322300,5,7,1,1,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YKL155C","RSM22",6322694,5,22,0,1,"Rsm22~Rsm22","NA","Eukaryota","Mitochondrial ribosomal protein of the small subunit"]
["YLL006W","MMM1",6323023,5,14,0,1,"DUF2404","NA","Eukaryota","Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins"]
["YLR067C","PET309",6323096,5,6,0,1,"NA","NA","Eukaryota","Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane"]
["YML081C-A","ATP18",6323558,5,17,0,1,"ATP-synt_J","NA","Eukaryota","Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms"]
["YMR108W","ILV2",6323755,5,3,0,1,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","2.2.1.6_Acetolactate synthase","cellular organisms","Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control"]
["YMR177W","MMT1",6323831,5,8,0,1,"Cation_efflux~Cation_efflux","NA","cellular organisms","Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p"]
["YNL122C","YNL122C",6324207,5,13,1,1,"Ribosomal_L35p","NA","Saccharomycetaceae","NA"]
["YOR228C","YOR228C",6324802,5,11,0,1,"DUF1691~DUF1691","NA","Ascomycota","NA"]
["YOR236W","DFR1",6324810,5,21,0,1,"DHFR_1","1.5.1.3_Dihydrofolate reductase","cellular organisms","Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function"]
["YPL104W","MSD1",6325153,5,22,0,1,"tRNA_anti~tRNA-synt_2","6.1.1.12_Aspartate--tRNA ligase","cellular organisms","Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene"]
["YPL107W","YPL107W",6325150,5,12,1,1,"Oxidored-like","NA","Ascomycota","NA"]
["YPR125W","YLH47",6325382,5,6,0,1,"LETM1","NA","Eukaryota","Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome"]
["YAL032C","PRP45",6319287,4,5,0,0,"SKIP_SNW","NA","Eukaryota","Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene"]
["YBL030C","PET9",6319441,4,2,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene"]
["YBL035C","POL12",6319436,4,5,0,0,"Pol_alpha_B_N~Pol_alpha_B_N~DNA_pol_E_B","NA","Eukaryota","B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation"]
["YBL081W","YBL081W",6319390,4,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBL101C","ECM21",6319367,4,6,0,0,"Arrestin_C","NA","Saccharomycetales","Non-essential protein of unknown function; promoter contains several Gcn4p binding elements"]
["YBL103C","RTG3",6319365,4,8,0,0,"HLH","NA","Fungi/Metazoa group","Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways"]
["YBR015C","MNN2",6319489,4,9,0,0,"NA","NA","cellular organisms","Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment"]
["YBR054W","YRO2",6319528,4,2,0,0,"NA","NA","Eukaryota","Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p"]
["YBR056W","YBR056W",6319530,4,24,1,0,"NA","NA","cellular organisms","NA"]
["YBR115C","LYS2",6319591,4,6,0,0,"AMP-binding~PP-binding~Epimerase~NAD_binding_4","1.2.1.31_L-aminoadipate-semialdehyde dehydrogenase","cellular organisms","Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p"]
["YBR123C","TFC1",6319600,4,6,0,0,"Tau95","NA","Eukaryota","One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63"]
["YBR126C","TPS1",6319602,4,19,0,0,"Glyco_transf_20","2.4.1.15_Alpha,alpha-trehalose-phosphate synthase (UDP-forming)","cellular organisms","Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway"]
["YBR186W","PCH2",9755327,4,5,0,0,"ABC_tran~NACHT~NB-ARC~AAA_3~AAA_5~AAA","NA","cellular organisms","Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA"]
["YBR187W","GDT1",6319664,4,18,1,0,"UPF0016~UPF0016","NA","cellular organisms","Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis"]
["YBR191W","RPL21A",6319668,4,9,0,0,"Ribosomal_L21e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein"]
["YBR196C","PGI1",6319673,4,6,0,0,"PGI","5.3.1.9_Glucose-6-phosphate isomerase","cellular organisms","Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation"]
["YBR201W","DER1",6319678,4,12,0,0,"DER1","NA","Eukaryota","Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p"]
["YBR202W","MCM7",6319679,4,2,0,0,"MCM","NA","cellular organisms","Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase"]
["YBR219C","YBR219C",6319696,4,13,1,0,"NA","NA","Fungi/Metazoa group","NA"]
["YBR225W","YBR225W",6319702,4,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBR241C","YBR241C",6319718,4,3,1,0,"Sugar_tr~MFS_1~MFS_1","NA","cellular organisms","NA"]
["YCL010C","SGF29",6319836,4,21,0,0,"DUF1325","NA","Eukaryota","SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex"]
["YCL042W","YCL042W",10383759,4,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YCR028C","FEN2",6319876,4,11,0,0,"MFS_1","NA","cellular organisms","Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph"]
["YCR047C","BUD23",6319895,4,9,0,0,"PrmA~PCMT~Methyltransf_11~Methyltransf_12","NA","cellular organisms","Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YCR053W","THR4",6319901,4,27,0,0,"PALP","4.2.3.1_Threonine synthase","cellular organisms","Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway"]
["YCR073W-A","SOL2",10383806,4,4,0,0,"NA","3.1.1.31_6-phosphogluconolactonase","cellular organisms","Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p"]
["YCR093W","CDC39",10383811,4,18,0,0,"Not1","NA","Eukaryota","Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor"]
["YCR094W","CDC50",6319937,4,37,0,0,"CDC50","NA","Eukaryota","Endosomal protein that regulates cell polarity, controls polarized growth; similar to Ynr048wp and Lem3p"]
["YCR101C","YCR101C",6319944,4,2,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDL003W","MCD1",6320201,4,3,0,0,"Rad21_Rec8_N~Rad21_Rec8","NA","Eukaryota","Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase"]
["YDL111C","RRP42",6320092,4,4,0,0,"RNase_PH~RNase_PH_C","NA","cellular organisms","Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p"]
["YDL124W","YDL124W",6320079,4,5,0,0,"Aldo_ket_red","NA","cellular organisms","NA"]
["YDL177C","YDL177C",6320024,4,4,1,0,"UPF0029~UPF0029","NA","cellular organisms","NA"]
["YDL206W","YDL206W",6319995,4,8,1,0,"Na_Ca_ex~Na_Ca_ex","NA","Eukaryota","NA"]
["YDL216C","RRI1",93117369,4,3,0,0,"Mov34","NA","Eukaryota","Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling"]
["YDR016C","DAD1",6320219,4,5,0,0,"DASH_Dad1","NA","Ascomycota","Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"]
["YDR035W","ARO3",6320240,4,22,0,0,"DAHP_synth_1","2.5.1.54_3-deoxy-7-phosphoheptulonate synthase","cellular organisms","3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan"]
["YDR091C","RLI1",6320296,4,2,0,0,"RLI~Fer4~ABC_tran~VirE~ABC_tran~DLIC~ABC_tran","NA","cellular organisms","Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase"]
["YDR127W","ARO1",6320332,4,54,0,0,"DHQ_synthase~EPSP_synthase~SKI~DHquinase_I~Shikimate_dh_N~Shikimate_DH","1.1.1.25_Shikimate dehydrogenase|2.5.1.19_3-phosphoshikimate 1-carboxyvinyltransferase|2.7.1.71_Shikimate kinase|4.2.1.10_3-dehydroquinate dehydratase|4.2.3.4_3-dehydroquinate synthase","cellular organisms","Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids"]
["YDR161W","YDR161W",6320365,4,5,1,0,"NA","NA","Eukaryota","NA"]
["YDR184C","ATC1",6320390,4,11,0,0,"NA","NA","Saccharomycetaceae","Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern"]
["YDR214W","AHA1",6320420,4,6,0,0,"Aha1_N~Mgm101p~AHSA1","NA","Eukaryota","Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock"]
["YDR254W","CHL4",6320460,4,19,0,0,"CHL4","NA","Ascomycota","Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p"]
["YDR266C","YDR266C",6320472,4,11,0,0,"NA","NA","Eukaryota","NA"]
["YDR275W","BSC2",6320481,4,7,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"]
["YDR301W","CFT1",6320507,4,9,0,0,"CPSF_A","NA","Eukaryota","RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF"]
["YDR338C","YDR338C",6320545,4,5,1,0,"MatE~MatE","NA","cellular organisms","NA"]
["YDR354W","TRP4",6320561,4,45,0,0,"Glycos_trans_3N~Glycos_transf_3","2.4.2.18_Anthranilate phosphoribosyltransferase","cellular organisms","Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis"]
["YDR363W","ESC2",6320570,4,3,0,0,"NA","NA","Ascomycota","Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins"]
["YDR392W","SPT3",6320600,4,21,0,0,"TFIID-18kDa","NA","Fungi/Metazoa group","Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters"]
["YDR393W","SHE9",6320601,4,11,0,0,"She9_MDM33","NA","Eukaryota","Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex"]
["YDR398W","UTP5",6320606,4,4,0,0,"NUC189","NA","Eukaryota","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YDR460W","TFB3",6320668,4,4,0,0,"MAT1","NA","Eukaryota","Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit"]
["YDR469W","SDC1",6320677,4,28,0,0,"Dpy-30","NA","Fungi/Metazoa group","Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30"]
["YDR502C","SAM2",6320710,4,7,0,0,"S-AdoMet_synt_N~S-AdoMet_synt_M~S-AdoMet_synt_C","NA","cellular organisms","S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"]
["YDR525W-A","SNA2",6320734,4,7,0,0,"UPF0057","NA","cellular organisms","Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YEL001C","IRC22",6320836,4,9,0,0,"NA","NA","Saccharomycetales","Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci"]
["YEL004W","YEA4",6320833,4,4,0,0,"UAA","NA","Eukaryota","Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER"]
["YEL009C","GCN4",6320828,4,20,0,0,"bZIP_1~bZIP_2","NA","Fungi/Metazoa group","Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels"]
["YEL013W","VAC8",6320824,4,6,0,0,"Arm~HEAT~Arm~Arm~Arm~HEAT~Arm~HEAT~Arm~Arm~Arm","NA","cellular organisms","Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions"]
["YEL017W","GTT3",6320820,4,22,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery"]
["YEL060C","PRB1",6320775,4,21,0,0,"Inhibitor_I9~Peptidase_S8","3.4.21.48_Cerevisin","cellular organisms","Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation"]
["YER018C","SPC25",6320855,4,2,0,0,"Phasin_2~Spindle_Spc25","NA","Saccharomycetaceae","Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"]
["YER021W","RPN3",6320859,4,7,0,0,"PCI~Rpn3_C","NA","Eukaryota","Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control"]
["YER054C","GIP2",6320895,4,6,0,0,"CBM_21","NA","Fungi/Metazoa group","Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p"]
["YER059W","PCL6",6320901,4,21,0,0,"Cyclin~Cyclin","NA","Eukaryota","Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding"]
["YER090W","TRP2",6320935,4,39,0,0,"Anth_synt_I_N~Chorismate_bind","4.1.3.27_Anthranilate synthase","cellular organisms","Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p"]
["YER101C","AST2",6320948,4,3,0,0,"ADH_N","NA","cellular organisms","Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions"]
["YER107C","GLE2",6320954,4,3,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p"]
["YER136W","GDI1",6320983,4,4,0,0,"GDI","NA","cellular organisms","GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins"]
["YER145C","FTR1",6320993,4,25,0,0,"FTR1","NA","cellular organisms","High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron"]
["YER180C","ISC10",6321028,4,3,0,0,"NA","NA","Saccharomycetaceae","Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells"]
["YFL009W","CDC4",14318513,4,4,0,0,"F-box~WD40~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p"]
["YFL042C","YFL042C",14318476,4,4,1,0,"GRAM","NA","Eukaryota","NA"]
["YFR009W","GCN20",14318531,4,8,0,0,"ABC_tran~ABC_tran~ABC_tran~NACHT","NA","cellular organisms","Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA"]
["YFR043C","IRC6",14318568,4,9,0,0,"Adaptin_binding","NA","Saccharomycetales","Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci"]
["YFR051C","RET2",14318576,4,5,0,0,"NA","NA","Eukaryota","Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER"]
["YGL076C","RPL7A",6321362,4,10,0,0,"Ribosomal_L30_N~Ribosomal_L30","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)"]
["YGL079W","YGL079W",6321359,4,6,1,0,"NA","NA","Ascomycota","NA"]
["YGL087C","MMS2",6321351,4,16,0,0,"UQ_con~RWD","NA","Eukaryota","Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p"]
["YGL124C","MON1",6321314,4,20,0,0,"Mon1","NA","Eukaryota","Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate"]
["YGL147C","RPL9A",6321291,4,4,0,0,"Ribosomal_L6~Ribosomal_L6","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins"]
["YGL148W","ARO2",6321290,4,61,0,0,"Chorismate_synt","4.2.3.5_Chorismate synthase","cellular organisms","Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids"]
["YGL173C","KEM1",6321265,4,5,0,0,"XRN_N","NA","Eukaryota","Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance"]
["YGL176C","YGL176C",6321262,4,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGL236C","MTO1",50593214,4,12,0,0,"AlaDh_PNT_C~GIDA~Pyr_redox_2","NA","cellular organisms","Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants"]
["YGL258W","VEL1",6321179,4,3,0,0,"Vel1p","NA","Ascomycota","Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants"]
["YGR006W","PRP18",41629693,4,6,0,0,"Prp18","NA","Eukaryota","Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p"]
["YGR074W","SMD1",6321510,4,5,0,0,"LSM","NA","Eukaryota","Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1"]
["YGR080W","TWF1",6321517,4,4,0,0,"Cofilin_ADF~Cofilin_ADF","NA","Eukaryota","Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly"]
["YGR092W","DBF2",6321529,4,22,0,0,"Pkinase~Pkinase_Tyr~Pkinase~Pkinase_C","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis"]
["YGR095C","RRP46",37362654,4,3,0,0,"RNase_PH~RNase_PH_C","NA","cellular organisms","Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex"]
["YGR105W","VMA21",6321542,4,28,0,0,"VMA21","NA","Ascomycota","Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)"]
["YGR135W","PRE9",6321574,4,13,0,0,"Proteasome_A_N~Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform"]
["YGR155W","CYS4",6321594,4,16,0,0,"PALP~CBS","4.2.1.22_Cystathionine beta-synthase","cellular organisms","Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis"]
["YGR168C","YGR168C",6321607,4,6,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YGR179C","OKP1",6321618,4,4,0,0,"NA","NA","Saccharomycetaceae","Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly"]
["YGR180C","RNR4",6321619,4,5,0,0,"Ribonuc_red_sm","1.17.4.1_Ribonucleoside-diphosphate reductase","cellular organisms","Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"]
["YGR187C","HGH1",6321626,4,9,0,0,"DUF383~DUF384","NA","Eukaryota","Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGR187C is not an essential gene"]
["YGR236C","SPG1",82795251,4,6,0,0,"NA","NA","Saccharomycetaceae","Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YGR252W","GCN5",6321691,4,25,0,0,"Acetyltransf_1~Bromodomain","2.3.1.48_Histone acetyltransferase","Eukaryota","Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily"]
["YGR266W","YGR266W",6321705,4,7,0,0,"NA","NA","cellular organisms","NA"]
["YGR267C","FOL2",6321706,4,8,0,0,"GTP_cyclohydroI","3.5.4.16_GTP cyclohydrolase I","cellular organisms","GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway"]
["YHR031C","RRM3",6321820,4,14,0,0,"NA","NA","cellular organisms","DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p"]
["YHR032W","YHR032W",6321821,4,5,1,0,"MatE~MatE","NA","cellular organisms","NA"]
["YHR079C","IRE1",6321870,4,12,0,0,"Pkinase~Pkinase_Tyr~Kdo~Ribonuc_2-5A","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress"]
["YHR094C","HXT1",6321886,4,5,0,0,"Sugar_tr~MFS_1~MFS_1","NA","cellular organisms","Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting"]
["YHR118C","ORC6",6321910,4,2,0,0,"ORC6","NA","Saccharomycetales","Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p"]
["YHR137W","ARO9",6321929,4,4,0,0,"NA","2.6.1.57_Aromatic-amino-acid transaminase","cellular organisms","Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism"]
["YIL008W","URM1",6322183,4,5,0,0,"Urm1~YchF-GTPase_C","NA","cellular organisms","Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature"]
["YIL014W","MNT3",6322176,4,8,0,0,"NA","NA","Ascomycota","Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation"]
["YIL018W","RPL2B",6322171,4,15,0,0,"Ribosomal_L2~Ribosomal_L2_C","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures"]
["YIL024C","YIL024C",6322165,4,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YIL046W","MET30",6322143,4,22,0,0,"F-box~WD40~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus"]
["YIL052C","RPL34B",6322137,4,17,0,0,"Ribosomal_L34e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein"]
["YIL067C","YIL067C",6322122,4,2,1,0,"LCCL","NA","Dikarya","NA"]
["YIL097W","FYV10",6322094,4,19,0,0,"NA","NA","Eukaryota","Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain"]
["YIL128W","MET18",6322063,4,6,0,0,"HEAT","NA","Eukaryota","DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance"]
["YIR008C","PRI1",6322198,4,5,0,0,"DNA_primase_S","NA","cellular organisms","Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair"]
["YIR038C","GTT1",6322229,4,3,0,0,"GST_N~GST_C","2.5.1.18_Glutathione transferase","cellular organisms","ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p"]
["YJL005W","CYR1",6322455,4,11,0,0,"Ad_cyc_g-alpha~RA~PP2C~Guanylate_cyc","4.6.1.1_Adenylate cyclase","Eukaryota","Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation"]
["YJL069C","UTP18",6322392,4,4,0,0,"WD40~WD40","NA","Eukaryota","Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"]
["YJL094C","KHA1",6322367,4,17,0,0,"Na_H_Exchanger","NA","cellular organisms","Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies"]
["YJL136C","RPS21B",6322325,4,8,0,0,"Ribosomal_S21e","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein"]
["YJL137C","GLG2",6322324,4,8,0,0,"Glyco_transf_8","2.4.1.186_Glycogenin glucosyltransferase","Eukaryota","Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin"]
["YJL172W","CPS1",6322289,4,3,0,0,"Peptidase_M20~M20_dimer","3.4.17.4_Gly-Xaa carboxypeptidase","cellular organisms","Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions"]
["YJL173C","RFA3",6322288,4,3,0,0,"Rep_fac-A_3","NA","Saccharomycetaceae","Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"]
["YJL189W","RPL39",6322272,4,4,0,0,"Ribosomal_L39","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1"]
["YJR036C","HUL4",6322497,4,3,0,0,"HECT","NA","Eukaryota","Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability"]
["YJR057W","CDC8",6322517,4,4,0,0,"Thymidylate_kin","2.7.4.9_dTMP kinase","cellular organisms","Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p"]
["YKL001C","MET14",6322852,4,12,0,0,"APS_kinase~PRK","2.7.1.25_Adenylyl-sulfate kinase","cellular organisms","Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism"]
["YKL007W","CAP1",6322845,4,20,0,0,"F-actin_cap_A","NA","Eukaryota","Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches"]
["YKL022C","CDC16",6322830,4,5,0,0,"TPR_1~TPR_2~TPR_1~TPR_2~TPR_1~TPR_1~TPR_2","NA","cellular organisms","Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation"]
["YKL033W","YKL033W",6322819,4,3,0,0,"NA","NA","Fungi/Metazoa group","NA"]
["YKL042W","SPC42",6322809,4,3,0,0,"NA","NA","Saccharomycetaceae","Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane"]
["YKL113C","RAD27",6322736,4,11,0,0,"XPG_N~XPG_I~5_3_exonuc","NA","cellular organisms","5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family"]
["YKL160W","ELF1",6322689,4,22,0,0,"Elf1","NA","cellular organisms","Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression"]
["YKL163W","PIR3",6322685,4,7,0,0,"PIR~PIR~PIR~PIR~PIR~PIR~PIR~PIR","NA","Ascomycota","O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway"]
["YKL184W","SPE1",6322664,4,6,0,0,"Orn_Arg_deC_N~Orn_DAP_Arg_deC","4.1.1.17_Ornithine decarboxylase","cellular organisms","Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines"]
["YKL205W","LOS1",6322644,4,13,0,0,"Xpo1","NA","Eukaryota","Nuclear pore protein involved in nuclear export of pre-tRNA"]
["YKL212W","SAC1",6322637,4,52,0,0,"Syja_N","NA","Eukaryota","Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism"]
["YKR001C","VPS1",6322853,4,27,0,0,"Dynamin_N~Dynamin_M~GED","NA","Eukaryota","Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis"]
["YKR079C","TRZ1",6322932,4,8,0,0,"NA","3.1.26.11_Ribonuclease Z","cellular organisms","tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2"]
["YKR093W","PTR2",6322946,4,27,0,0,"MFS_1~PTR2","NA","cellular organisms","Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p"]
["YLL039C","UBI4",6322989,4,17,0,0,"ubiquitin~ubiquitin~ubiquitin~ubiquitin~ubiquitin","NA","cellular organisms","Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats"]
["YLR022C","SDO1",6323050,4,39,0,0,"SBDS~SBDS_C","NA","cellular organisms","Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes"]
["YLR024C","UBR2",6323052,4,11,0,0,"zf-UBR","NA","Eukaryota","Cytoplasmic ubiquitin-protein ligase (E3)"]
["YLR077W","FMP25",6323106,4,8,1,0,"NA","NA","cellular organisms","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YLR087C","CSF1",6323116,4,29,0,0,"NA","NA","Dikarya","Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YLR110C","CCW12",6323139,4,10,0,0,"NA","NA","Saccharomycetales","Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor"]
["YLR153C","ACS2",6323182,4,16,0,0,"AMP-binding","6.2.1.1_Acetate--CoA ligase","cellular organisms","Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions"]
["YLR165C","PUS5",6323194,4,5,0,0,"PseudoU_synth_2","NA","cellular organisms","Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability"]
["YLR176C","RFX1",6323205,4,18,0,0,"RFX_DNA_binding","NA","Fungi/Metazoa group","Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins"]
["YLR186W","EMG1",6323215,4,5,0,0,"EMG1","NA","cellular organisms","Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers"]
["YLR218C","YLR218C",6323247,4,4,1,0,"CHCH","NA","Fungi/Metazoa group","NA"]
["YLR220W","CCC1",6323249,4,11,0,0,"DUF125","NA","cellular organisms","Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation"]
["YLR240W","VPS34",6323269,4,15,0,0,"PI3K_C2~PI3Ka~PI3_PI4_kinase","NA","Eukaryota","Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p"]
["YLR262C-A","TMA7",6323292,4,8,0,0,"TMA7","NA","Eukaryota","Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin"]
["YLR273C","PIG1",6323303,4,7,0,0,"CBM_21","NA","Saccharomycetaceae","Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase"]
["YLR315W","NKP2",6323347,4,6,0,0,"Cnl2_NKP2","NA","Saccharomycetaceae","Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)"]
["YLR324W","PEX30",6323356,4,19,0,0,"Pex24p","NA","Dikarya","Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p"]
["YLR336C","SGD1",6323368,4,3,0,0,"MIF4G~MA3","NA","Eukaryota","Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia"]
["YLR344W","RPL26A",6323376,4,3,0,0,"KOW","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA"]
["YLR347C","KAP95",6323379,4,7,0,0,"IBN_N~Arm~HEAT","NA","Eukaryota","Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex"]
["YLR380W","CSR1",6323412,4,13,0,0,"CRAL_TRIO_N~CRAL_TRIO","NA","Eukaryota","Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance"]
["YML007W","YAP1",6323636,4,27,0,0,"bZIP_2~bZIP_1~PAP1","NA","Ascomycota","Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium"]
["YML018C","YML018C",6323623,4,9,1,0,"DUF6~DUF914","NA","cellular organisms","NA"]
["YML026C","RPS18B",6323615,4,3,0,0,"Ribosomal_S13","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins"]
["YML038C","YMD8",6323603,4,7,0,0,"DUF6~TPT","NA","Eukaryota","Putative nucleotide sugar transporter, has similarity to Vrg4p"]
["YML085C","TUB1",6323554,4,11,0,0,"Tubulin~Tubulin_C","NA","cellular organisms","Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules"]
["YML097C","VPS9",6323541,4,21,0,0,"VPS9~CUE","NA","Eukaryota","A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin"]
["YML126C","ERG13",6323509,4,5,0,0,"HMG_CoA_synt_N~HMG_CoA_synt_C","2.3.3.10_Hydroxymethylglutaryl-CoA synthase","cellular organisms","3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis"]
["YMR022W","UBC7",6323664,4,11,0,0,"UQ_con","6.3.2.19_Ubiquitin--protein ligase","Eukaryota","Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly"]
["YMR053C","STB2",6323698,4,11,0,0,"NA","NA","Dikarya","Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p"]
["YMR070W","MOT3",6323715,4,17,0,0,"zf-C2H2","NA","Fungi/Metazoa group","Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes"]
["YMR095C","SNO1",6323742,4,4,0,0,"SNO~GATase_3","NA","cellular organisms","Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase"]
["YMR099C","YMR099C",6323746,4,12,0,0,"Aldose_epim","NA","cellular organisms","NA"]
["YMR138W","CIN4",6323787,4,13,0,0,"Arf~cobW~GTP_EFTU","NA","cellular organisms","GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog"]
["YMR229C","RRP5",6323885,4,6,0,0,"S1~S1~S1","NA","cellular organisms","RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome"]
["YMR255W","GFD1",6323911,4,7,0,0,"NA","NA","Saccharomycetaceae","Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation"]
["YMR295C","YMR295C",6323953,4,7,0,0,"DUF2406","NA","Ascomycota","NA"]
["YNL025C","SSN8",6324303,4,14,0,0,"Cyclin_N","NA","Eukaryota","Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance"]
["YNL029C","KTR5",6324300,4,4,0,0,"Glyco_transf_15","2.4.1.131_Glycolipid 2-alpha-mannosyltransferase","Fungi","Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family"]
["YNL038W","GPI15",37362689,4,3,0,0,"PIG-H","NA","Ascomycota","Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein"]
["YNL067W","RPL9B",6324262,4,5,0,0,"Ribosomal_L6~Ribosomal_L6","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins"]
["YNL069C","RPL16B",6324260,4,5,0,0,"Ribosomal_L13","NA","cellular organisms","N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p"]
["YNL087W","TCB2",6324242,4,7,0,0,"C2~C2~C2","NA","Eukaryota","Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud"]
["YNL107W","YAF9",6324222,4,15,0,0,"YEATS~PEP-utilisers_N~Osmo_CC","NA","Eukaryota","Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain"]
["YNL153C","GIM3",6324176,4,3,0,0,"Prefoldin_2~FliD_C","NA","Eukaryota","Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it"]
["YNL154C","YCK2",6324175,4,17,0,0,"Pkinase~Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p"]
["YNL157W","IGO1",6324172,4,5,1,0,"Endosulfine~Lg106","NA","Ascomycota","Hypothetical protein"]
["YNL182C","IPI3",6324147,4,2,0,0,"WD40","NA","Eukaryota","Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"]
["YNL188W","KAR1",6324141,4,3,0,0,"NA","NA","Saccharomycetaceae","Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p"]
["YNL206C","RTT106",6324123,4,16,0,0,"Rtt106","NA","Eukaryota","Protein with a role in regulation of Ty1 transposition"]
["YNL207W","RIO2",6324122,4,5,0,0,"Rio2_N~RIO1","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p"]
["YNL262W","POL2",6324067,4,3,0,0,"DNA_pol_B_exo~DNA_pol_B~DUF1744","2.7.7.7_DNA-directed DNA polymerase","cellular organisms","Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair"]
["YNL264C","PDR17",6324065,4,20,0,0,"CRAL_TRIO_N~CRAL_TRIO","NA","Eukaryota","Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition"]
["YNL287W","SEC21",6324042,4,5,0,0,"Adaptin_N~Gamma-COP","NA","Eukaryota","Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo"]
["YNL291C","MID1",6324038,4,22,0,0,"NA","NA","Dikarya","N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer"]
["YNL311C","SKP2",6324018,4,6,0,0,"F-box","NA","Saccharomycetaceae","NA"]
["YNL326C","PFA3",6324003,4,14,0,0,"zf-DHHC","NA","Eukaryota","Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions"]
["YNL330C","RPD3",6323999,4,10,0,0,"Hist_deacetyl","3.5.1.98_Histone deacetylase","cellular organisms","Histone deacetylase; regulates transcription and silencing; plays a role in regulating Ty1 transposition"]
["YNL334C","SNO2",6323995,4,3,0,0,"SNO~GATase_3","NA","cellular organisms","Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin"]
["YNR006W","VPS27",6324332,4,29,0,0,"VHS~FYVE","NA","Fungi/Metazoa group","Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)"]
["YNR008W","LRO1",6324335,4,11,0,0,"LACT","2.3.1.158_Phospholipid:diacylglycerol acyltransferase","Eukaryota","Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase"]
["YOL003C","PFA4",6324571,4,14,0,0,"zf-DHHC","NA","Eukaryota","Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases"]
["YOL044W","PEX15",6324529,4,7,0,0,"NA","NA","Saccharomycetaceae","Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly"]
["YOL058W","ARG1",6324514,4,5,0,0,"Arginosuc_synth~ExsB","6.3.4.5_Argininosuccinate synthase","cellular organisms","Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate"]
["YOL080C","REX4",6324493,4,7,0,0,"Exonuc_X-T","NA","cellular organisms","Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly"]
["YOL081W","IRA2",6324491,4,31,0,0,"RasGAP","NA","Fungi/Metazoa group","GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin"]
["YOL146W","PSF3",37362690,4,3,0,0,"Psf3~Psf3","NA","Eukaryota","Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"]
["YOR003W","YSP3",6324576,4,9,0,0,"Inhibitor_I9~Peptidase_S8","NA","cellular organisms","Putative precursor to the subtilisin-like protease III"]
["YOR026W","BUB3",6324600,4,7,0,0,"WD40","NA","Eukaryota","Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p"]
["YOR090C","PTC5",6324664,4,3,0,0,"PP2C","NA","Eukaryota","Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p"]
["YOR098C","NUP1",6324672,4,9,0,0,"Nup_retrotrp_bd","NA","Dikarya","Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate"]
["YOR151C","RPB2",6324725,4,10,0,0,"RNA_pol_Rpb2_1~RNA_pol_Rpb2_2~RNA_pol_Rpb2_3~RNA_pol_Rpb2_4~RNA_pol_Rpb2_5~RNA_pol_Rpb2_6~RNA_pol_Rpb2_7","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit"]
["YOR156C","NFI1",6324730,4,4,0,0,"SAP~zf-MIZ","NA","Eukaryota","SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length"]
["YOR193W","PEX27",6324767,4,6,0,0,"NA","NA","Saccharomycetaceae","Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p"]
["YOR210W","RPB10",6324784,4,11,0,0,"RNA_pol_N","NA","cellular organisms","RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III"]
["YOR212W","STE4",6324786,4,7,0,0,"WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats"]
["YOR227W","YOR227W",6324801,4,7,0,0,"NA","NA","Ascomycota","NA"]
["YOR288C","MPD1",6324862,4,9,0,0,"Thioredoxin~AhpC-TSA","5.3.4.1_Protein disulfide-isomerase","cellular organisms","Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation"]
["YOR352W","YOR352W",6324928,4,7,1,0,"NA","NA","Saccharomycetales","NA"]
["YOR377W","ATF1",6324953,4,24,0,0,"AATase","2.3.1.84_Alcohol O-acetyltransferase","Saccharomycetaceae","Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation"]
["YPL001W","HAT1",6325256,4,4,0,0,"Hat1_N~Acetyltransf_1","2.3.1.48_Histone acetyltransferase","Eukaryota","Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair"]
["YPL009C","YPL009C",6325248,4,13,0,0,"FbpA","NA","cellular organisms","NA"]
["YPL098C","MGR2",6325159,4,13,0,0,"Mit_gmP","NA","Fungi/Metazoa group","Protein required for growth of cells lacking the mitochondrial genome"]
["YPL156C","PRM4",6325101,4,7,0,0,"Alb1","NA","Saccharomycetales","Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift"]
["YPL199C","YPL199C",6325057,4,13,1,0,"DUF1771~Smr","NA","Eukaryota","NA"]
["YPL236C","YPL236C",6325020,4,8,1,0,"Pkinase~Pkinase","NA","cellular organisms","NA"]
["YPL253C","VIK1",6325002,4,6,0,0,"NA","NA","Saccharomycetaceae","Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p"]
["YPL273W","SAM4",6324982,4,32,0,0,"S-methyl_trans","2.1.1.10_Homocysteine S-methyltransferase","cellular organisms","S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio"]
["YPR042C","PUF2",6325299,4,5,0,0,"RRM_1~PUF~PUF~PUF~PUF~PUF","NA","Eukaryota","Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins"]
["YPR120C","CLB5",6325377,4,15,0,0,"Cyclin_N~Cyclin_C","NA","Eukaryota","B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase"]
["YPR139C","VPS66",6325397,4,9,0,0,"NA","NA","Ascomycota","Cytoplasmic protein of unknown function involved in vacuolar protein sorting."]
["YPR153W","YPR153W",154200012,4,14,0,0,"NA","NA","Ascomycota","NA"]
["YPR194C","OPT2",6325452,4,8,0,0,"OPT","NA","Eukaryota","Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans"]
["YPR198W","SGE1",6325455,4,16,0,0,"MFS_1~Sugar_tr~TRI12","NA","cellular organisms","Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations"]
["YBL015W","ACH1",6319456,4,19,0,1,"AcetylCoA_hydro","3.1.2.1_Acetyl-CoA hydrolase","cellular organisms","Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth"]
["YBR003W","COQ1",6319475,4,14,0,1,"polyprenyl_synt~polyprenyl_synt","NA","cellular organisms","Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis"]
["YDR231C","COX20",6320437,4,6,0,1,"NA","NA","Ascomycota","Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase"]
["YGL143C","MRF1",6321295,4,11,0,1,"PCRF~RF-1","NA","cellular organisms","Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability"]
["YGR062C","COX18",6321499,4,6,0,1,"NA","NA","Fungi/Metazoa group","Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC"]
["YGR096W","TPC1",6321533,4,3,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family"]
["YGR222W","PET54",6321661,4,10,0,1,"NA","NA","Saccharomycetales","Mitochondrial inner membrane protein that binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing"]
["YIL093C","RSM25",6322098,4,20,0,1,"NA","NA","Dikarya","Mitochondrial ribosomal protein of the small subunit"]
["YLL027W","ISA1",6323001,4,10,0,1,"Fe-S_biosyn","NA","cellular organisms","Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources"]
["YLR253W","YLR253W",6323282,4,2,1,1,"ABC1","NA","cellular organisms","NA"]
["YML129C","COX14",6323506,4,11,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes"]
["YOR017W","PET127",6324591,4,5,0,1,"Pet127","NA","Eukaryota","Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane"]
["YPL183W-A","YPL183W-A",6325073,4,10,0,1,"Ribosomal_L36","NA","cellular organisms","Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity"]
["YPL270W","MDL2",37362699,4,6,0,1,"ABC_membrane~ABC_tran","NA","Saccharomyces cerevisiae","Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter"]
["YAL041W","CDC24",6319276,3,2,0,0,"CDC24~RhoGEF~PB1","NA","Eukaryota","Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing"]
["YAR014C","BUD14",41629669,3,14,0,0,"SH3_1","NA","Saccharomycetaceae","Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YBL006C","LDB7",41629675,3,46,0,0,"Rsc14~DUF1909","NA","Saccharomycetaceae","Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions"]
["YBL023C","MCM2",6319448,3,9,0,0,"MCM~AAA_5","NA","cellular organisms","Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex"]
["YBL033C","RIB1",6319438,3,5,0,0,"GTP_cyclohydro2","3.5.4.25_GTP cyclohydrolase II","cellular organisms","GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway"]
["YBR014C","GRX7",6319488,3,5,0,0,"Glutaredoxin","NA","cellular organisms","Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6"]
["YBR031W","RPL4A",6319505,3,4,0,0,"Ribosomal_L4","NA","cellular organisms","N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins"]
["YBR091C","MRS5",6319567,3,36,0,0,"zf-Tim10_DDP","NA","Eukaryota","Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins"]
["YBR143C","SUP45",6319619,3,7,0,0,"eRF1_1~eRF1_2~eRF1_3","NA","cellular organisms","Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor"]
["YBR162C","TOS1",6319638,3,12,0,0,"DUF2403~DUF2401","NA","cellular organisms","Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C"]
["YBR162W-A","YSY6",6319639,3,10,0,0,"NA","NA","Saccharomycetales","Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion"]
["YBR172C","SMY2",37362621,3,4,0,0,"GYF","NA","Saccharomycetaceae","Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2"]
["YBR210W","ERV15",6319687,3,10,0,0,"Cornichon","NA","Eukaryota","Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p"]
["YBR215W","HPC2",154199602,3,27,0,0,"HPC2","NA","Saccharomycetaceae","Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes"]
["YBR257W","POP4",6319734,3,16,0,0,"NA","NA","Eukaryota","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P"]
["YBR289W","SNF5",6319766,3,33,0,0,"SNF5","NA","Ascomycota","Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p"]
["YBR290W","BSD2",6319767,3,33,0,0,"DUF2370","NA","Dikarya","Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification"]
["YCL030C","HIS4",10383761,3,4,0,0,"PRA-CH~PRA-PH~Histidinol_dh","1.1.1.23_Histidinol dehydrogenase|3.5.4.19_Phosphoribosyl-AMP cyclohydrolase|3.6.1.31_Phosphoribosyl-ATP diphosphatase","cellular organisms","Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis"]
["YCR009C","RVS161",6319854,3,26,0,0,"BAR","NA","Eukaryota","Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress"]
["YCR014C","POL4",10383782,3,7,0,0,"NA","2.7.7.7_DNA-directed DNA polymerase","Eukaryota","DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta"]
["YCR016W","YCR016W",10383784,3,7,1,0,"DUF2373","NA","Saccharomycetales","NA"]
["YCR020C","PET18",6319866,3,5,0,0,"NA","NA","cellular organisms","Protein required for respiratory growth and stability of the mitochondrial genome"]
["YCR035C","RRP43",10383796,3,12,0,0,"RNase_PH~RNase_PH_C","NA","Ascomycota","Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA"]
["YCR050C","YCR050C",6319898,3,8,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YCR051W","YCR051W",6319899,3,3,1,0,"Ank","NA","cellular organisms","NA"]
["YCR054C","CTR86",6319902,3,7,0,0,"Atx10homo_assoc","NA","Saccharomycetales","Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis"]
["YDL015C","TSC13",6320189,3,4,0,0,"Steroid_dh","NA","Eukaryota","Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p"]
["YDL019C","OSH2",6320185,3,4,0,0,"Ank~PH~Oxysterol_BP","NA","Eukaryota","Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"]
["YDL039C","PRM7",6320165,3,2,0,0,"NA","NA","Saccharomyces cerevisiae","Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements"]
["YDL075W","RPL31A",6320128,3,2,0,0,"Ribosomal_L31e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p"]
["YDL093W","PMT5",6320109,3,2,0,0,"PMT~MIR","2.4.1.109_Dolichyl-phosphate-mannose-protein mannosyltransferase","cellular organisms","Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals"]
["YDL097C","RPN6",6320106,3,2,0,0,"PCI","NA","Eukaryota","Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion"]
["YDL109C","YDL109C",6320094,3,11,1,0,"DUF676","NA","Eukaryota","NA"]
["YDL112W","TRM3",6320091,3,6,0,0,"SpoU_methylase","2.1.1.34_tRNA guanosine-2'-O-methyltransferase","Ascomycota","2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs"]
["YDL190C","UFD2",6320011,3,24,0,0,"Ufd2P_core~U-box","NA","Eukaryota","Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3"]
["YDL198C","GGC1",6320003,3,14,0,0,"Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family"]
["YDR002W","YRB1",6320205,3,2,0,0,"Ran_BP1","NA","Eukaryota","Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1"]
["YDR018C","YDR018C",6320221,3,5,1,0,"Acyltransferase","NA","cellular organisms","NA"]
["YDR044W","HEM13",6320249,3,3,0,0,"Coprogen_oxidas","1.3.3.3_Coproporphyrinogen oxidase","cellular organisms","Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)"]
["YDR050C","TPI1",6320255,3,3,0,0,"TIM","5.3.1.1_Triose-phosphate isomerase","cellular organisms","Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region"]
["YDR064W","RPS13",6320269,3,5,0,0,"Ribosomal_S13_N~Ribosomal_S15","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins"]
["YDR132C","YDR132C",6320337,3,2,1,0,"NA","NA","Ascomycota","NA"]
["YDR135C","YCF1",6320339,3,15,0,0,"ABC_membrane~ABC_tran~ABC_membrane~ABC_tran","NA","cellular organisms","Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR"]
["YDR156W","RPA14",6320360,3,36,0,0,"RNA_polI_A14","NA","Saccharomycetaceae","RNA polymerase I subunit A14"]
["YDR163W","CWC15",6320367,3,6,0,0,"Cwf_Cwc_15","NA","Eukaryota","Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p"]
["YDR211W","GCD6",6320417,3,9,0,0,"W2","NA","cellular organisms","Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"]
["YDR223W","CRF1",6320429,3,4,0,0,"CRF1","NA","Saccharomyces cerevisiae","Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus"]
["YDR243C","PRP28",6320449,3,8,0,0,"DEAD~Helicase_C","NA","cellular organisms","RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site"]
["YDR272W","GLO2",6320478,3,3,0,0,"Lactamase_B","3.1.2.6_Hydroxyacylglutathione hydrolase","cellular organisms","Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate"]
["YDR279W","RNH202",6320485,3,6,0,0,"RNase_H2-Ydr279","NA","Saccharomycetaceae","Ribonuclease H2 subunit, required for RNase H2 activity"]
["YDR294C","DPL1",6320500,3,10,0,0,"Pyridoxal_deC","4.1.2.27_Sphinganine-1-phosphate aldolase","cellular organisms","Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate"]
["YDR303C","RSC3",6320509,3,9,0,0,"Zn_clus","NA","Saccharomycetaceae","Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p"]
["YDR308C","SRB7",6320514,3,7,0,0,"CSE2","NA","Fungi/Metazoa group","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p"]
["YDR336W","YDR336W",6320543,3,12,1,0,"MMR_HSR1","NA","cellular organisms","NA"]
["YDR357C","YDR357C",6320564,3,9,1,0,"NA","NA","Saccharomycetales","NA"]
["YDR372C","VPS74",6320580,3,36,0,0,"GPP34","NA","cellular organisms","Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; functions as a heterotetramer"]
["YDR373W","FRQ1",6320581,3,6,0,0,"efhand~efhand~efhand","NA","cellular organisms","N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily"]
["YDR374C","YDR374C",6320582,3,10,1,0,"YTH","NA","Eukaryota","NA"]
["YDR381W","YRA1",6320589,3,3,0,0,"RRM_1","NA","cellular organisms","Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function"]
["YDR382W","RPP2B",6320590,3,5,0,0,"Ribosomal_60s","NA","Eukaryota","Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm"]
["YDR389W","SAC7",6320597,3,36,0,0,"RhoGAP~RhoGAP","NA","Fungi/Metazoa group","GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate"]
["YDR404C","RPB7",6320612,3,10,0,0,"RNA_pol_Rpb7_N~S1","NA","cellular organisms","RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p"]
["YDR418W","RPL12B",6320625,3,3,0,0,"Ribosomal_L11_N~Ribosomal_L11","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins"]
["YDR429C","TIF35",6320637,3,3,0,0,"RRM_1","NA","cellular organisms","Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation"]
["YDR437W","GPI19",6320645,3,5,0,0,"PIG-P","NA","Ascomycota","Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P"]
["YDR496C","PUF6",6320704,3,8,0,0,"NA","NA","Eukaryota","Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA"]
["YDR499W","LCD1",6320707,3,4,0,0,"LCD1","NA","Saccharomycetales","Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP"]
["YEL016C","NPP2",6320821,3,4,0,0,"Phosphodiest","3.1.4.1_Phosphodiesterase I|3.6.1.9_Nucleotide diphosphatase","cellular organisms","Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation"]
["YEL037C","RAD23",6320798,3,36,0,0,"ubiquitin~UBA~XPC-binding~UBA","NA","Eukaryota","Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins"]
["YEL041W","YEF1",6320794,3,2,0,0,"NAD_kinase","NA","cellular organisms","ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes"]
["YEL046C","GLY1",6320789,3,13,0,0,"Beta_elim_lyase","4.1.2.5_Threonine aldolase","cellular organisms","Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis"]
["YER045C","ACA1",6320885,3,15,0,0,"bZIP_1~bZIP_2","NA","Saccharomycetaceae","Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources"]
["YER055C","HIS1",6320896,3,5,0,0,"HisG~HisG_C","2.4.2.17_ATP phosphoribosyltransferase","cellular organisms","ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control"]
["YER056C-A","RPL34A",9755331,3,7,0,0,"Ribosomal_L34e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein"]
["YER058W","PET117",6320900,3,7,0,0,"NA","NA","Fungi/Metazoa group","Protein required for assembly of cytochrome c oxidase"]
["YER094C","PUP3",6320941,3,8,0,0,"Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10"]
["YER112W","LSM4",6320958,3,12,0,0,"LSM","NA","Eukaryota","Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"]
["YER126C","NSA2",6320973,3,2,0,0,"Ribosomal_S8e","NA","cellular organisms","Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA"]
["YFL003C","MSH4",14318519,3,3,0,0,"MutS_II~MutS_III~MutS_IV~MutS_V","NA","cellular organisms","Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein"]
["YFL025C","BST1",14318494,3,22,0,0,"PGAP1","NA","Eukaryota","GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules"]
["YFL029C","CAK1",14318490,3,3,0,0,"Pkinase~Pkinase~YrbL-PhoP_reg","2.7.11.22_Cyclin-dependent kinase","cellular organisms","Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases"]
["YFL053W","DAK2",14318466,3,9,0,0,"Dak1~Dak2","2.7.1.29_Glycerone kinase","cellular organisms","Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation"]
["YFL060C","SNO3",14318459,3,5,0,0,"SNO~GATase_3","NA","cellular organisms","Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin"]
["YFR002W","NIC96",14318524,3,4,0,0,"Nic96","NA","Eukaryota","Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p"]
["YFR010W","UBP6",14318532,3,27,0,0,"ubiquitin~UCH","3.1.2.15_Ubiquitin thiolesterase","Eukaryota","Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to polyubiquitin elongation activity of Hul5p"]
["YFR022W","ROG3",14318544,3,3,0,0,"Arrestin_N~Arrestin_C","NA","Dikarya","Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant"]
["YFR031C-A","RPL2A",14318555,3,3,0,0,"Ribosomal_L2~Ribosomal_L2_C","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins"]
["YFR032C","YFR032C",14318556,3,10,1,0,"RRM_1","NA","Eukaryota","NA"]
["YFR035C","YFR035C",14318560,3,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YFR041C","ERJ5",14318566,3,6,0,0,"DnaJ","NA","cellular organisms","Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response"]
["YFR055W","IRC7",14318580,3,16,1,0,"Cys_Met_Meta_PP","4.4.1.8_Cystathionine beta-lyase","cellular organisms","Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner"]
["YGL058W","RAD6",6321380,3,25,0,0,"UQ_con","6.3.2.19_Ubiquitin--protein ligase","Eukaryota","Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)"]
["YGL082W","YGL082W",6321356,3,9,1,0,"DUF544","NA","Eukaryota","NA"]
["YGL113W","SLD3",6321325,3,6,0,0,"SLD3","NA","Ascomycota","Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p"]
["YGL139W","FLC3",6321299,3,5,0,0,"TRP","NA","Dikarya","Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER"]
["YGL168W","HUR1",6321270,3,18,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene"]
["YGL174W","BUD13",6321264,3,3,0,0,"DUF2050","NA","Eukaryota","Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern"]
["YGL198W","YIP4",41629692,3,21,0,0,"Yip1","NA","Eukaryota","Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport"]
["YGL241W","KAP114",6321196,3,6,0,0,"IBN_N","NA","Eukaryota","Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear"]
["YGR063C","SPT4",6321501,3,8,0,0,"Spt4","NA","Eukaryota","Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing"]
["YGR068C","YGR068C",6321506,3,6,0,0,"Arrestin_C","NA","Ascomycota","NA"]
["YGR108W","CLB1",6321545,3,3,0,0,"Cyclin_N~Cyclin_C","NA","Eukaryota","B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"]
["YGR113W","DAM1",14318436,3,3,0,0,"DASH_Dam1","NA","Ascomycota","Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments"]
["YGR211W","ZPR1",6321650,3,3,0,0,"zf-ZPR1~zf-ZPR1","NA","cellular organisms","Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)"]
["YGR218W","CRM1",6321657,3,7,0,0,"IBN_N~Xpo1~CRM1_C","NA","Eukaryota","Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus"]
["YGR254W","ENO1",6321693,3,5,0,0,"Enolase_N~Enolase_C","4.2.1.11_Phosphopyruvate hydratase","cellular organisms","Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose"]
["YHR013C","ARD1",6321801,3,19,0,0,"Acetyltransf_1","2.3.1.88_Peptide alpha-N-acetyltransferase","cellular organisms","Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"]
["YHR019C","DED81",6321807,3,6,0,0,"tRNA_anti~tRNA-synt_2","6.1.1.22_Asparagine--tRNA ligase","cellular organisms","Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA"]
["YHR025W","THR1",6321814,3,37,0,0,"GHMP_kinases_N~GHMP_kinases_C","2.7.1.39_Homoserine kinase","cellular organisms","Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway"]
["YHR151C","YHR151C",6321945,3,11,0,0,"NA","NA","Ascomycota","Putative protein of unknown function; YHR151C is synthetically sick with cdc13-1"]
["YHR190W","ERG9",6321984,3,6,0,0,"SQS_PSY","2.5.1.21_Squalene synthase","cellular organisms","Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway"]
["YIL010W","DOT5",6322180,3,11,0,0,"Redoxin~AhpC-TSA","1.11.1.15_Peroxiredoxin","cellular organisms","Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth"]
["YIL037C","PRM2",6322152,3,2,0,0,"NA","NA","Saccharomycetaceae","Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p"]
["YIL079C","AIR1",6322111,3,10,0,0,"zf-CCHC~zf-CCHC~zf-CCHC","NA","Eukaryota","RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p"]
["YIL115C","NUP159",6322076,3,3,0,0,"NA","NA","Ascomycota","Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export"]
["YIL126W","STH1",6322065,3,8,0,0,"SNF2_N~Helicase_C~Bromodomain","NA","cellular organisms","ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p"]
["YIL173W","VTH1",6322020,3,11,0,0,"NA","NA","Eukaryota","Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting"]
["YJL011C","RPC17",6322449,3,4,0,0,"RNA_pol_III_C17","NA","Eukaryota","RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex"]
["YJL031C","BET4",41629687,3,5,0,0,"PPTA~PPTA~PPTA~PPTA~PPTA","2.5.1.60_Protein geranylgeranyltransferase type II","Eukaryota","Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p"]
["YJL068C","YJL068C",6322393,3,2,0,0,"Esterase","3.1.2.12_S-formylglutathione hydrolase","cellular organisms","NA"]
["YJL070C","YJL070C",6322391,3,5,1,0,"A_deaminase~A_deaminase","NA","Eukaryota","NA"]
["YJL083W","TAX4",6322378,3,6,0,0,"NA","NA","Saccharomycetaceae","EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"]
["YJL091C","GWT1",37362667,3,4,0,0,"GWT1","NA","Eukaryota","Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors"]
["YJL109C","UTP10",6322352,3,6,0,0,"BP28CT","NA","Eukaryota","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YJL165C","HAL5",6322296,3,40,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters"]
["YJL204C","RCY1",6322257,3,75,0,0,"F-box~Sec10","NA","Fungi/Metazoa group","F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth"]
["YJR009C","TDH2",6322468,3,6,0,0,"DapB_N~Gp_dh_N~Gp_dh_C","1.2.1.12_Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)","cellular organisms","Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall"]
["YJR052W","RAD7",6322512,3,12,0,0,"NA","NA","Eukaryota","Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex"]
["YJR065C","ARP3",6322525,3,10,0,0,"Actin","NA","cellular organisms","Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity"]
["YJR070C","LIA1",6322531,3,3,0,0,"HEAT_PBS~HEAT_PBS~HEAT_PBS","1.14.99.29_Deoxyhypusine monooxygenase","cellular organisms","Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning"]
["YKL017C","HCS1",6322835,3,7,0,0,"ResIII~UvrD-helicase","NA","cellular organisms","Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities"]
["YKL028W","TFA1",6322824,3,2,0,0,"TFIIE_alpha","NA","Eukaryota","TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening"]
["YKL048C","ELM1",6322803,3,14,0,0,"Pkinase~Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring"]
["YKL050C","YKL050C",6322801,3,9,0,0,"NA","NA","Saccharomycetales","NA"]
["YKL058W","TOA2",6322792,3,10,0,0,"TFIIA_gamma_N~TFIIA_gamma_C","NA","Eukaryota","TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA"]
["YKL063C","YKL063C",6322787,3,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YKL104C","GFA1",6322745,3,14,0,0,"GATase_2~SIS~SIS","2.6.1.16_Glutamine--fructose-6-phosphate transaminase (isomerizing)","cellular organisms","Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis"]
["YKL108W","SLD2",6322741,3,9,0,0,"NA","NA","Ascomycota","Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate"]
["YKL135C","APL2",6322714,3,44,0,0,"Adaptin_N~HEAT","NA","Eukaryota","Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting"]
["YKL161C","YKL161C",6322688,3,9,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","NA"]
["YKL168C","KKQ8",99030927,3,7,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Putative serine/threonine protein kinase with unknown cellular role"]
["YKR101W","SIR1",6322954,3,8,0,0,"NA","NA","Saccharomycetaceae","Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin"]
["YLL043W","FPS1",6322985,3,18,0,0,"MIP","NA","cellular organisms","Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress"]
["YLR015W","BRE2",6323043,3,37,0,0,"NA","NA","Dikarya","Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L"]
["YLR055C","SPT8",6323084,3,24,0,0,"NA","NA","cellular organisms","Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters"]
["YLR129W","DIP2",6323158,3,3,0,0,"WD40~WD40~WD40~Hira~WD40~WD40~WD40~WD40~WD40~Utp12","NA","cellular organisms","Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex"]
["YLR137W","YLR137W",6323166,3,19,1,0,"NA","NA","Ascomycota","NA"]
["YLR175W","CBF5",6323204,3,5,0,0,"DKCLD~TruB_N~PUA","NA","cellular organisms","Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2"]
["YLR177W","YLR177W",6323206,3,7,1,0,"PSP1","NA","cellular organisms","NA"]
["YLR228C","ECM22",6323257,3,15,0,0,"Zn_clus","NA","Ascomycota","Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p"]
["YLR242C","ARV1",6323271,3,12,0,0,"Arv1~Arv1","NA","Ascomycota","Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein"]
["YLR243W","YLR243W",6323272,3,8,1,0,"ATP_bind_1","NA","cellular organisms","NA"]
["YLR258W","GSY2",6323287,3,7,0,0,"Glycogen_syn~Glycos_transf_1","2.4.1.11_Glycogen(starch) synthase","cellular organisms","Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase"]
["YLR271W","YLR271W",6323301,3,4,1,0,"G-patch","NA","Fungi/Metazoa group","NA"]
["YLR297W","YLR297W",6323328,3,7,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YLR304C","ACO1",6323335,3,10,0,0,"Aconitase~Aconitase_C","4.2.1.3_Aconitate hydratase","cellular organisms","Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy"]
["YLR332W","MID2",6323363,3,9,0,0,"Mid2","NA","Saccharomycetaceae","O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p"]
["YLR350W","ORM2",6323382,3,21,0,0,"ORMDL","NA","Eukaryota","Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum"]
["YLR367W","RPS22B",6323399,3,11,0,0,"Ribosomal_S8","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins"]
["YLR368W","MDM30",6323400,3,5,0,0,"F-box","NA","Saccharomycetaceae","F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains"]
["YLR427W","MAG2",6323459,3,5,0,0,"zf-C3HC4","NA","Eukaryota","Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes the hydrolysis of alkylated DNA"]
["YLR460C","YLR460C",6323493,3,11,1,0,"ADH_N~ADH_zinc_N","NA","cellular organisms","NA"]
["YML006C","GIS4",6323637,3,16,0,0,"NA","NA","Saccharomycetaceae","CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway"]
["YML035C","AMD1",6323606,3,5,0,0,"A_deaminase","3.5.4.6_AMP deaminase","Eukaryota","AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools"]
["YML043C","RRN11",6323598,3,3,0,0,"RNA_pol_I_TF","NA","Saccharomycetales","Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p"]
["YML064C","TEM1",6323576,3,4,0,0,"Miro~Ras~Ras","NA","cellular organisms","GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis"]
["YML124C","TUB3",6323511,3,18,0,0,"Tubulin~Tubulin_C","NA","cellular organisms","Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p"]
["YMR015C","ERG5",6323657,3,37,0,0,"p450","NA","cellular organisms","C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs"]
["YMR016C","SOK2",6323658,3,22,0,0,"KilA-N","NA","Saccharomyces cerevisiae","Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors"]
["YMR021C","MAC1",6323663,3,14,0,0,"Copper-fist","NA","Saccharomycetales","Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport"]
["YMR028W","TAP42",6323670,3,5,0,0,"TAP42","NA","Eukaryota","Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits"]
["YMR149W","SWP1",6323798,3,5,0,0,"NA","2.4.1.119_Dolichyl-diphosphooligosaccharide--protein glycotransferase","Eukaryota","Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum"]
["YMR183C","SSO2",6323837,3,34,0,0,"Syntaxin~SNARE","NA","Eukaryota","Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p"]
["YMR243C","ZRC1",6323899,3,8,0,0,"Cation_efflux~Cation_efflux","NA","cellular organisms","Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm"]
["YMR253C","YMR253C",6323909,3,8,1,0,"DUF6~TPT~DUF6","NA","cellular organisms","NA"]
["YMR264W","CUE1",6323920,3,36,0,0,"CUE","NA","Dikarya","Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination"]
["YMR283C","RIT1",6323939,3,21,0,0,"Init_tRNA_PT","NA","Eukaryota","2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA"]
["YNL014W","HEF3",6324314,3,2,0,0,"ATP-synt_ab~ABC_tran~ABC_tran~DUF258~MMR_HSR1~Dynamin_N","NA","cellular organisms","Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells"]
["YNL066W","SUN4",6324263,3,8,0,0,"SUN","NA","Eukaryota","Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family"]
["YNL075W","IMP4",6324254,3,3,0,0,"Brix","NA","cellular organisms","Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs"]
["YNL092W","YNL092W",6324237,3,2,1,0,"N2227","NA","Eukaryota","NA"]
["YNL111C","CYB5",6324218,3,19,0,0,"Cyt-b5","NA","cellular organisms","Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation"]
["YNL117W","MLS1",6324212,3,2,0,0,"Malate_synthase","2.3.3.9_Malate synthase","cellular organisms","Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium"]
["YNL138W","SRV2",6324191,3,17,0,0,"CAP_N~CAP_C","NA","Eukaryota","CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis"]
["YNL144C","YNL144C",6324185,3,6,1,0,"NA","NA","Ascomycota","NA"]
["YNL216W","RAP1",6324113,3,6,0,0,"BRCT~Myb_DNA-binding~Rap1-DNA-bind","NA","Ascomycota","DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure"]
["YNL224C","SQS1",6324105,3,21,0,0,"G-patch","NA","Ascomycota","Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"]
["YNL231C","PDR16",6324098,3,28,0,0,"CRAL_TRIO_N~CRAL_TRIO","NA","Eukaryota","Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p"]
["YNL236W","SIN4",6324093,3,20,0,0,"NA","NA","Saccharomycetales","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription"]
["YNL240C","NAR1",6324089,3,2,0,0,"Fe_hyd_lg_C~Fe_hyd_lg_C","NA","cellular organisms","Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf"]
["YNL271C","BNI1",6324058,3,22,0,0,"Drf_GBD~Drf_FH3~FH2","NA","Dikarya","Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1"]
["YNL293W","MSB3",6324036,3,18,0,0,"TBC~TBC","NA","Eukaryota","GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth"]
["YNL308C","KRI1",6324021,3,3,0,0,"Kri1","NA","Eukaryota","Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p"]
["YNR019W","ARE2",6324346,3,11,0,0,"MBOAT","2.3.1.26_Sterol O-acyltransferase","Eukaryota","Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen"]
["YNR029C","YNR029C",6324356,3,12,1,0,"cobW~CobW_C","NA","cellular organisms","NA"]
["YNR033W","ABZ1",6324361,3,2,0,0,"GATase~Anth_synt_I_N~Chorismate_bind","2.6.1.85_Aminodeoxychorismate synthase","cellular organisms","Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB"]
["YNR047W","YNR047W",6324375,3,11,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","NA"]
["YNR048W","YNR048W",6324376,3,4,0,0,"CDC50","NA","Eukaryota","NA"]
["YOL002C","IZH2",27808716,3,6,0,0,"HlyIII","NA","cellular organisms","Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc"]
["YOL010W","RCL1",6324564,3,2,0,0,"RTC~RTC_insert","NA","cellular organisms","RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity"]
["YOL015W","IRC10",6324558,3,4,0,0,"NA","NA","Saccharomyces cerevisiae","Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci"]
["YOL030W","GAS5",6324543,3,6,0,0,"Glyco_hydro_72","NA","cellular organisms","1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall"]
["YOL038W","PRE6",6324535,3,10,0,0,"Proteasome_A_N~Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress"]
["YOL060C","MAM3",6324512,3,8,0,0,"DUF21~CBS","NA","cellular organisms","Protein required for normal mitochondrial morphology, has similarity to hemolysins"]
["YOL067C","RTG1",6324505,3,8,0,0,"HLH","NA","Saccharomycetales","Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus"]
["YOL072W","THP1",6324500,3,25,0,0,"PCI","NA","Eukaryota","Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding"]
["YOL111C","MDY2",6324461,3,9,0,0,"ubiquitin","NA","Fungi/Metazoa group","Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain"]
["YOL122C","SMF1",6324450,3,5,0,0,"Nramp","NA","cellular organisms","Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins"]
["YOL126C","MDH2",116006499,3,6,0,0,"Ldh_1_N~Ldh_1_C","1.1.1.37_Malate dehydrogenase","cellular organisms","Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1"]
["YOL129W","VPS68",6324443,3,12,0,0,"UPF0220","NA","Eukaryota","Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria"]
["YOR061W","CKA2",6324635,3,34,0,0,"Pkinase~Pkinase_Tyr~APH","NA","cellular organisms","Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases"]
["YOR062C","YOR062C",6324636,3,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR081C","TGL5",6324655,3,9,0,0,"Patatin","3.1.1.3_Triacylglycerol lipase","cellular organisms","Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate"]
["YOR083W","WHI5",6324656,3,10,0,0,"Whi5","NA","Saccharomycetaceae","Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1"]
["YOR104W","PIN2",6324678,3,12,0,0,"NA","NA","Saccharomycetales","Protein that induces appearance of [PIN+] prion when overproduced"]
["YOR114W","YOR114W",6324688,3,2,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR116C","RPO31",6324690,3,19,0,0,"RNA_pol_Rpb1_1~RNA_pol_Rpb1_2~RNA_pol_Rpb1_3~RNA_pol_Rpb1_4~RNA_pol_Rpb1_5","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit"]
["YOR134W","BAG7",6324708,3,6,0,0,"RhoGAP","NA","Eukaryota","Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p"]
["YOR162C","YRR1",6324736,3,16,0,0,"Zn_clus","NA","Ascomycota","Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes"]
["YOR213C","SAS5",6324787,3,14,0,0,"YEATS","NA","Eukaryota","Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity"]
["YOR260W","GCD1",6324834,3,16,0,0,"NTP_transferase~Fucokinase","NA","Eukaryota","Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"]
["YOR321W","PMT3",6324897,3,9,0,0,"PMT~MIR","2.4.1.109_Dolichyl-phosphate-mannose-protein mannosyltransferase","cellular organisms","Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals"]
["YOR341W","RPA190",6324917,3,4,0,0,"RNA_pol_Rpb1_1~RNA_pol_Rpb1_2~RNA_pol_Rpb1_3~RNA_pol_Rpb1_4~RNA_pol_Rpb1_5","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","RNA polymerase I subunit; largest subunit of RNA polymerase I"]
["YOR344C","TYE7",6324920,3,7,0,0,"HLH","NA","Eukaryota","Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression"]
["YOR373W","NUD1",6324949,3,2,0,0,"NA","NA","cellular organisms","Component of the spindle pole body outer plaque, required for exit from mitosis"]
["YOR382W","FIT2",6324958,3,2,0,0,"NA","NA","Saccharomycetaceae","Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"]
["YPL012W","RRP12",6325245,3,3,0,0,"NUC173","NA","Eukaryota","Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats"]
["YPL094C","SEC62",41629689,3,6,0,0,"Sec62","NA","Eukaryota","Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"]
["YPL113C","YPL113C",6325144,3,12,1,0,"2-Hacid_dh_C","NA","cellular organisms","NA"]
["YPL139C","UME1",6325118,3,22,0,0,"WD40","NA","Eukaryota","Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p"]
["YPL144W","POC4",6325113,3,25,0,0,"chaperone_DMP","NA","Saccharomycetaceae","Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions"]
["YPL149W","ATG5",6325108,3,7,0,0,"APG5","NA","Eukaryota","Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation"]
["YPL189W","GUP2",6325067,3,4,0,0,"MBOAT","NA","cellular organisms","Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog"]
["YPL191C","YPL191C",6325065,3,5,1,0,"DUF544","NA","Eukaryota","NA"]
["YPL211W","NIP7",6325045,3,3,0,0,"UPF0113","NA","cellular organisms","Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p"]
["YPL233W","NSL1",6325023,3,29,0,0,"Mis14","NA","Ascomycota","Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation"]
["YPL241C","CIN2",6325015,3,15,0,0,"NA","NA","Saccharomycetaceae","GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2"]
["YPL255W","BBP1",6325000,3,3,0,0,"NA","NA","Saccharomycetaceae","Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p"]
["YPR003C","YPR003C",6325260,3,10,1,0,"Sulfate_transp~STAS","NA","cellular organisms","NA"]
["YPR030W","CSR2",6325287,3,4,0,0,"NA","NA","Saccharomycetales","Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate"]
["YPR043W","RPL43A",6325300,3,7,0,0,"Ribosomal_L37ae","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype"]
["YPR085C","YPR085C",37362704,3,11,0,0,"NA","NA","Ascomycota","NA"]
["YPR114W","YPR114W",6325371,3,5,1,0,"TRAM_LAG1_CLN8","NA","Eukaryota","NA"]
["YPR124W","CTR1",6325380,3,17,0,0,"NA","NA","Saccharomycetales","High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels"]
["YPR133W-A","TOM5",6325391,3,9,0,0,"Tom5","NA","Saccharomycetaceae","Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p"]
["YPR165W","RHO1",6325423,3,14,0,0,"Miro~Ras","NA","cellular organisms","GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)"]
["YPR169W","JIP5",83578109,3,4,0,0,"NA","NA","Fungi/Metazoa group","Nucleolar protein of unknown function, exhibits a physical interaction with Bre1p"]
["YPR176C","BET2",6325434,3,3,0,0,"Prenyltrans~Prenyltrans~Prenyltrans~Prenyltrans~Prenyltrans","NA","Eukaryota","Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p"]
["YBL045C","COR1",6319426,3,3,0,1,"Peptidase_M16~Peptidase_M16_C","NA","cellular organisms","Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain"]
["YBR230C","OM14",6319707,3,4,0,1,"NA","NA","Saccharomycetaceae","Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron"]
["YCL064C","CHA1",63535562,3,4,0,1,"PALP","4.3.1.17_L-serine ammonia-lyase|4.3.1.19_Threonine ammonia-lyase","cellular organisms","Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine"]
["YCR024C","SLM5",6319872,3,8,0,1,"tRNA_anti~tRNA-synt_2","6.1.1.22_Asparagine--tRNA ligase","cellular organisms","Mitochondrial asparaginyl-tRNA synthetase"]
["YER141W","COX15",6320989,3,8,0,1,"COX15-CtaA","NA","cellular organisms","Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase"]
["YGL080W","FMP37",6321358,3,10,1,1,"UPF0041","NA","Eukaryota","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YGR015C","YGR015C",6321452,3,3,1,1,"Abhydrolase_1~PGAP1","NA","cellular organisms","NA"]
["YLR090W","XDJ1",6323119,3,20,0,1,"DnaJ~DnaJ_CXXCXGXG~DnaJ_CXXCXGXG~DnaJ_CXXCXGXG~DnaJ_C","NA","cellular organisms","Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YLR193C","UPS1",6323222,3,12,0,1,"PRELI","NA","Eukaryota","Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI"]
["YLR204W","QRI5",6323233,3,29,0,1,"DUF1713","NA","Saccharomyces cerevisiae","Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA"]
["YML086C","ALO1",6323553,3,10,0,1,"FAD_binding_4~ALO","1.1.3.37_D-arabinono-1,4-lactone oxidase","cellular organisms","D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress"]
["YMR166C","YMR166C",6323818,3,7,1,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","NA"]
["YNL037C","IDH1",6324291,3,13,0,1,"Iso_dh","1.1.1.41_Isocitrate dehydrogenase (NAD(+))","cellular organisms","Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle"]
["YNL081C","SWS2",6324248,3,12,0,1,"Ribosomal_S13","NA","cellular organisms","Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency"]
["YNL100W","AIM37",6324229,3,6,1,1,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YNL168C","FMP41",6324161,3,3,1,1,"FAA_hydrolase","NA","cellular organisms","Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YNR017W","TIM23",6324344,3,3,0,1,"Tim17","NA","Eukaryota","Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system"]
["YNR022C","MRPL50",6324349,3,5,0,1,"MutS_IV","NA","Saccharomycetaceae","Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"]
["YOL027C","MDM38",6324546,3,5,0,1,"LETM1","NA","Eukaryota","Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome"]
["YOR330C","MIP1",83578108,3,10,0,1,"DNA_pol_A","2.7.7.7_DNA-directed DNA polymerase","Fungi/Metazoa group","Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome."]
["YOR354C","MSC6",6324930,3,6,0,1,"NA","NA","Saccharomycetaceae","Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YPL013C","MRPS16",6325244,3,14,0,1,"Ribosomal_S16","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YPL063W","TIM50",6325194,3,7,0,1,"NIF","NA","Eukaryota","Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocation"]
["YPL091W","GLR1",6325166,3,16,0,1,"DAO~Pyr_redox_2~Pyr_redox~Pyr_redox_dim","1.8.1.7_Glutathione-disulfide reductase","cellular organisms","Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione"]
["YPL252C","YAH1",6325004,3,7,0,1,"Fer2","NA","cellular organisms","Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin"]
["YAL005C","SSA1",144228166,2,10,0,0,"HSP70","NA","cellular organisms","ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall"]
["YAL016W","TPD3",6319303,2,2,0,0,"HEAT~HEAT~HEAT~HEAT~HEAT~HEAT~HEAT","NA","Eukaryota","Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III"]
["YAL019W","FUN30",6319300,2,10,0,0,"SNF2_N~Helicase_C","NA","cellular organisms","Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YAL020C","ATS1",6319299,2,10,0,0,"NA","NA","cellular organisms","Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle"]
["YAL043C","PTA1",6319273,2,4,0,0,"NA","NA","Dikarya","Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII"]
["YAR019C","CDC15",6319328,2,6,0,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p"]
["YBL016W","FUS3",6319455,2,5,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.24_Mitogen-activated protein kinase","cellular organisms","Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation"]
["YBL026W","LSM2",6319445,2,35,0,0,"LSM","NA","Eukaryota","Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"]
["YBL043W","ECM13",6319428,2,5,0,0,"NA","NA","Saccharomyces cerevisiae","Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation"]
["YBL050W","SEC17",6319421,2,11,0,0,"NA","NA","Eukaryota","Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP"]
["YBR009C","HHF1",6319481,2,8,0,0,"Histone~CBFD_NFYB_HMF~TAF","NA","Eukaryota","One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity"]
["YBR038W","CHS2",6319512,2,2,0,0,"Chitin_synth_1N~Chitin_synth_1~Chitin_synth_2~Chitin_synth_2","2.4.1.16_Chitin synthase","cellular organisms","Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis"]
["YBR045C","GIP1",6319519,2,6,0,0,"NA","NA","Saccharomycetaceae","Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p"]
["YBR059C","AKL1",6319533,2,12,0,0,"Pkinase~Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization"]
["YBR070C","ALG14",6319544,2,5,0,0,"Alg14","NA","cellular organisms","Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases"]
["YBR142W","MAK5",6319618,2,2,0,0,"DEAD~Helicase_C","NA","cellular organisms","Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits"]
["YBR151W","APD1",6319627,2,7,0,0,"Suc_Fer-like","NA","Eukaryota","Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus"]
["YBR159W","IFA38",6319635,2,3,0,0,"adh_short~KR","NA","cellular organisms","Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides"]
["YBR160W","CDC28",6319636,2,2,0,0,"Pkinase~Pkinase_Tyr","NA","cellular organisms","Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates"]
["YBR165W","UBS1",6319642,2,14,0,0,"NA","NA","Saccharomycetaceae","Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity"]
["YBR234C","ARC40",6319711,2,4,0,0,"WD40~WD40","NA","cellular organisms","Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"]
["YBR254C","TRS20",6319731,2,5,0,0,"Sedlin_N~Sybindin","NA","Eukaryota","One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder"]
["YBR265W","TSC10",6319742,2,18,0,0,"adh_short~adh_short","NA","cellular organisms","3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family"]
["YCL047C","YCL047C",6319802,2,2,1,0,"DUF2432","NA","Dikarya","NA"]
["YCR012W","PGK1",10383781,2,10,0,0,"PGK","2.7.2.3_Phosphoglycerate kinase","cellular organisms","3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis"]
["YCR063W","BUD31",6319908,2,12,0,0,"G10","NA","Eukaryota","Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YCR086W","CSM1",6319928,2,10,0,0,"DUF881~Ribosomal_MRP8~Cauli_AT~BRE1~Spindle_Spc25","NA","Saccharomycetales","Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance"]
["YDL010W","GRX6",6320193,2,2,0,0,"Glutaredoxin","NA","cellular organisms","Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6"]
["YDL042C","SIR2",6320163,2,2,0,0,"DUF592~SIR2","NA","cellular organisms","Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication"]
["YDL127W","PCL2",42742057,2,2,0,0,"Cyclin~Cyclin_N","NA","Eukaryota","G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth"]
["YDL138W","RGT2",6320063,2,3,0,0,"Sugar_tr~MFS_1~MFS_1","NA","cellular organisms","Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes"]
["YDL147W","RPN5",6320054,2,4,0,0,"PCI","NA","Eukaryota","Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p"]
["YDL191W","RPL35A",6320010,2,3,0,0,"Ribosomal_L29","NA","Eukaryota","Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein"]
["YDL208W","NHP2",82795243,2,2,0,0,"Ribosomal_L7Ae","NA","cellular organisms","Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing"]
["YDL214C","PRR2",6319987,2,6,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor"]
["YDL231C","BRE4",6319970,2,3,0,0,"NA","NA","Dikarya","Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport"]
["YDL233W","YDL233W",6319968,2,12,1,0,"NA","NA","Dikarya","NA"]
["YDR022C","CIS1",6320225,2,3,0,0,"Atg31","NA","Saccharomycetaceae","Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion"]
["YDR025W","RPS11A",6320228,2,3,0,0,"Ribosomal_S17","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins"]
["YDR026C","YDR026C",6320229,2,8,0,0,"Myb_DNA-binding~Myb_DNA-binding","NA","Eukaryota","NA"]
["YDR043C","NRG1",6320248,2,4,0,0,"zf-C2H2","NA","Eukaryota","Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response"]
["YDR054C","CDC34",6320259,2,3,0,0,"UQ_con","6.3.2.19_Ubiquitin--protein ligase","Eukaryota","Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation"]
["YDR072C","IPT1",6320277,2,34,0,0,"PAP2~PAP2","NA","cellular organisms","Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media"]
["YDR081C","PDC2",6320286,2,4,0,0,"CenpB-DNA-bind~DDE","NA","Eukaryota","Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes"]
["YDR117C","TMA64",6320322,2,4,0,0,"SUI1","NA","Eukaryota","Protein of unknown function that associates with ribosomes; has a putative RNA binding domain"]
["YDR118W","APC4",6320323,2,3,0,0,"NA","NA","Saccharomycetaceae","Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"]
["YDR121W","DPB4",6320326,2,3,0,0,"NA","2.7.7.7_DNA-directed DNA polymerase","Eukaryota","Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing"]
["YDR122W","KIN1",6320327,2,4,0,0,"Pkinase~Pkinase~Pkinase_Tyr~Pkinase_Tyr~KA1","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p"]
["YDR124W","YDR124W",6320329,2,8,1,0,"NA","NA","Ascomycota","NA"]
["YDR159W","SAC3",6320363,2,29,0,0,"SAC3_GANP","NA","Fungi/Metazoa group","Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus"]
["YDR213W","UPC2",6320419,2,20,0,0,"Zn_clus","NA","Ascomycota","Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog"]
["YDR270W","CCC2",6320475,2,36,0,0,"HMA~HMA~E1-E2_ATPase~Hydrolase~Hydrolase_3","3.6.3.4_Copper-exporting ATPase","cellular organisms","Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases"]
["YDR283C","GCN2",6320489,2,15,0,0,"RWD~Pkinase~Pkinase~Pkinase~Pkinase_Tyr~Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex"]
["YDR302W","GPI11",6320508,2,4,0,0,"PIG-F","NA","Eukaryota","ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog"]
["YDR314C","RAD34",6320520,2,8,0,0,"BHD_1~BHD_2~BHD_3","NA","Ascomycota","Protein involved in nucleotide excision repair (NER); homologous to RAD4"]
["YDR331W","GPI8",6320538,2,4,0,0,"Peptidase_C13~Peptidase_C13","NA","cellular organisms","ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog"]
["YDR341C","YDR341C",6320548,2,4,0,0,"Arg_tRNA_synt_N~tRNA-synt_1d~DALR_1","6.1.1.19_Arginine--tRNA ligase","cellular organisms","NA"]
["YDR352W","YDR352W",6320559,2,3,1,0,"PQ-loop~PQ-loop","NA","Eukaryota","NA"]
["YDR395W","SXM1",6320603,2,22,0,0,"IBN_N","NA","Eukaryota","Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1"]
["YDR399W","HPT1",6320607,2,7,0,0,"Pribosyltran","2.4.2.8_Hypoxanthine phosphoribosyltransferase","cellular organisms","Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome"]
["YDR400W","URH1",37362635,2,6,0,0,"IU_nuc_hydro","3.2.2.3_Uridine nucleosidase","cellular organisms","Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways"]
["YDR443C","SSN2",6320651,2,7,0,0,"NA","NA","Ascomycota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation"]
["YDR477W","SNF1",6320685,2,14,0,0,"Pkinase~Pkinase_Tyr~UBA_2","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis"]
["YDR479C","PEX29",6320687,2,17,0,0,"Pex24p","NA","Dikarya","Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p"]
["YDR495C","VPS3",6320703,2,27,0,0,"NA","NA","Saccharomycetaceae","Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase"]
["YDR519W","FPR2",6320727,2,2,0,0,"FKBP_C","NA","cellular organisms","Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking"]
["YDR531W","YDR531W",6320740,2,3,1,0,"Fumble","2.7.1.33_Pantothenate kinase","cellular organisms","NA"]
["YDR533C","HSP31",6320742,2,5,0,0,"DJ-1_PfpI","NA","cellular organisms","Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site"]
["YEL055C","POL5",6320780,2,2,0,0,"DNA_pol_phi","2.7.7.7_DNA-directed DNA polymerase","Eukaryota","DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA"]
["YEL063C","CAN1",6320772,2,9,0,0,"AA_permease","NA","cellular organisms","Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance"]
["YER056C","FCY2",6320897,2,10,0,0,"Transp_cyt_pur","NA","cellular organisms","Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation"]
["YER125W","RSP5",6320972,2,11,0,0,"C2~WW~WW~WW~HECT","NA","Eukaryota","Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain"]
["YER157W","COG3",6321005,2,9,0,0,"Sec34","NA","Eukaryota","Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YER171W","RAD3",6321019,2,3,0,0,"DEAD_2~DUF1227","NA","cellular organisms","5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein"]
["YER172C","BRR2",6321020,2,3,0,0,"DEAD~Helicase_C~Sec63~DEAD~Sec63","NA","cellular organisms","RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD"]
["YER186C","YER186C",6321034,2,2,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YFL007W","BLM10",37362646,2,10,0,0,"NA","NA","Fungi/Metazoa group","Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200"]
["YFL013C","IES1",14318508,2,13,0,0,"NA","NA","Dikarya","Subunit of the INO80 chromatin remodeling complex"]
["YFL022C","FRS2",14318497,2,3,0,0,"tRNA-synt_2d","6.1.1.20_Phenylalanine--tRNA ligase","cellular organisms","Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar"]
["YFL037W","TUB2",14318481,2,7,0,0,"Tubulin~Tubulin_C","NA","cellular organisms","Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules"]
["YFR004W","RPN11",14318526,2,14,0,0,"Mov34","NA","Eukaryota","Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates"]
["YFR023W","PES4",14318545,2,7,0,0,"RRM_1~RRM_1~RRM_1","NA","Eukaryota","Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p"]
["YFR027W","ECO1",14318550,2,3,0,0,"NA","NA","Eukaryota","Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair"]
["YFR030W","MET10",14318553,2,7,0,0,"FAD_binding_1~NAD_binding_1","NA","cellular organisms","Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide"]
["YFR033C","QCR6",14318558,2,5,0,0,"UCR_hinge","NA","Dikarya","Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1"]
["YGL022W","STT3",6321416,2,2,0,0,"STT3","2.4.1.119_Dolichyl-diphosphooligosaccharide--protein glycotransferase","cellular organisms","Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis"]
["YGL039W","YGL039W",6321399,2,4,0,0,"Epimerase","NA","cellular organisms","NA"]
["YGL066W","SGF73",6321372,2,15,0,0,"SCA7","NA","Ascomycota","Subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters; null mutant displays defects in premeiotic DNA synthesis"]
["YGL070C","RPB9",6321368,2,19,0,0,"RNA_POL_M_15KD~TFIIS_C","NA","cellular organisms","RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance"]
["YGL078C","DBP3",6321360,2,3,0,0,"DEAD~ResIII~Helicase_C","NA","cellular organisms","Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis"]
["YGL092W","NUP145",6321346,2,6,0,0,"Nucleoporin2","NA","Eukaryota","Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p"]
["YGL093W","SPC105",6321345,2,26,0,0,"Spc7","NA","Ascomycota","Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp"]
["YGL101W","YGL101W",6321337,2,6,1,0,"HD","NA","cellular organisms","NA"]
["YGL128C","CWC23",37362651,2,2,0,0,"DnaJ","NA","cellular organisms","Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p"]
["YGL144C","ROG1",6321294,2,6,0,0,"DUF676","NA","Eukaryota","Protein with putative serine active lipase domain"]
["YGL151W","NUT1",6321287,2,16,0,0,"Med5","NA","Ascomycota","Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription"]
["YGL161C","YIP5",6321277,2,15,0,0,"Yip1","NA","Eukaryota","Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport"]
["YGL197W","MDS3",6321241,2,5,0,0,"Kelch_1~Kelch_2~Kelch_1","NA","Ascomycota","Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions"]
["YGL207W","SPT16",6321231,2,12,0,0,"SPT16~Rtt106","NA","Eukaryota","Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure"]
["YGL213C","SKI8",6321225,2,9,0,0,"WD40~WD40","NA","cellular organisms","Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses"]
["YGL238W","CSE1",6321198,2,6,0,0,"IBN_N~Xpo1~Cse1~CAS_CSE1","NA","Eukaryota","Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation"]
["YGR060W","ERG25",6321497,2,6,0,0,"FA_hydroxylase","NA","cellular organisms","C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol"]
["YGR070W","ROM1",6321507,2,7,0,0,"DEP~RhoGEF~CNH","NA","Fungi/Metazoa group","GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP"]
["YGR090W","UTP22",6321527,2,3,0,0,"Nrap","NA","Eukaryota","Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"]
["YGR100W","MDR1",6321537,2,11,0,0,"GRAM~TBC~efhand","NA","Eukaryota","Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function"]
["YGR134W","CAF130",6321573,2,6,0,0,"NA","NA","Saccharomycetales","Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation"]
["YGR186W","TFG1",6321625,2,2,0,0,"TFIIF_alpha","NA","Eukaryota","TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74"]
["YGR194C","XKS1",6321633,2,6,0,0,"FGGY_N~FGGY_N~FGGY_C","2.7.1.17_Xylulokinase","cellular organisms","Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains"]
["YGR198W","YPP1",6321637,2,13,0,0,"NA","NA","Saccharomycetaceae","Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene"]
["YGR209C","TRX2",6321648,2,7,0,0,"Thioredoxin~Redoxin~AhpC-TSA","NA","cellular organisms","Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance"]
["YGR221C","TOS2",6321660,2,7,0,0,"SKG6","NA","Saccharomycetaceae","Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p"]
["YGR229C","SMI1",6321668,2,48,0,0,"SMI1_KNR4","NA","cellular organisms","Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity"]
["YGR240C","PFK1",6321679,2,10,0,0,"PFK~PFK~PFK","NA","cellular organisms","Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes"]
["YGR253C","PUP2",6321692,2,7,0,0,"Proteasome_A_N~Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta"]
["YGR284C","ERV29",6321723,2,6,0,0,"SURF4","NA","cellular organisms","Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo"]
["YHR035W","YHR035W",6321824,2,36,1,0,"Sec23_helical","NA","Eukaryota","NA"]
["YHR085W","IPI1",6321877,2,4,0,0,"NA","NA","Fungi/Metazoa group","Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"]
["YHR103W","SBE22",6321895,2,30,0,0,"NA","NA","Saccharomycetales","Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth"]
["YHR105W","YPT35",6321897,2,2,0,0,"PX","NA","Saccharomycetales","Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport"]
["YHR113W","YHR113W",6321905,2,6,0,0,"Peptidase_M18","NA","cellular organisms","NA"]
["YHR154W","RTT107",6321948,2,11,0,0,"BRCT~BRCT~BRCT~BRCT","NA","Ascomycota","Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition"]
["YHR160C","PEX18",6321954,2,13,0,0,"NA","NA","Saccharomycetaceae","Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p"]
["YHR167W","THP2",6321961,2,18,0,0,"THP2","NA","Saccharomycetaceae","Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance"]
["YHR172W","SPC97",6321966,2,8,0,0,"Spc97_Spc98","NA","Eukaryota","Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque"]
["YIL060W","YIL060W",6322129,2,7,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YIL154C","IMP2'",6322037,2,62,0,0,"NA","NA","Ascomycota","Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat"]
["YIR025W","MND2",6322216,2,3,0,0,"Apc15p","NA","Saccharomycetaceae","Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division"]
["YJL077C","ICS3",6322384,2,7,0,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function"]
["YJL080C","SCP160",6322381,2,25,0,0,"KH_1~KH_1~KH_1~KH_1~KH_1~KH_1~KH_2","NA","Eukaryota","Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins"]
["YJL081C","ARP4",6322380,2,59,0,0,"Actin~Actin","NA","cellular organisms","Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"]
["YJL095W","BCK1",6322366,2,53,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","Eukaryota","Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p"]
["YJL101C","GSH1",6322360,2,18,0,0,"GCS","6.3.2.2_Glutamate--cysteine ligase","Eukaryota","Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury"]
["YJL143W","TIM17",6322318,2,9,0,0,"Tim17","NA","Eukaryota","Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import"]
["YJL145W","SFH5",6322316,2,12,0,0,"CRAL_TRIO_N~CRAL_TRIO","NA","Eukaryota","Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP"]
["YJL177W","RPL17B",6322284,2,2,0,0,"Ribosomal_L22","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins"]
["YJR004C","SAG1",6322463,2,9,0,0,"Candida_ALS","NA","Saccharomycetales","Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor"]
["YJR041C","URB2",6322501,2,2,0,0,"Urb2","NA","Saccharomycetales","Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis"]
["YJR088C","YJR088C",6322547,2,10,1,0,"TPR_2","NA","Eukaryota","NA"]
["YJR100C","AIM25",6322560,2,3,1,0,"Scramblase","NA","cellular organisms","Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation); similar to murine NOR1"]
["YJR109C","CPA2",6322569,2,6,0,0,"CPSase_L_chain~CPSase_L_D2~CPSase_L_D3~CPSase_L_chain~CPSase_L_D2","6.3.5.5_Carbamoyl-phosphate synthase (glutamine-hydrolyzing)","cellular organisms","Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor"]
["YJR116W","YJR116W",6322576,2,8,1,0,"TRAM_LAG1_CLN8","NA","Eukaryota","NA"]
["YJR130C","STR2",6322590,2,7,0,0,"PDE6_gamma","2.5.1.48_Cystathionine gamma-synthase","cellular organisms","Cystathionine gamma-synthase, converts cysteine into cystathionine"]
["YKL009W","MRT4",6322843,2,6,0,0,"Ribosomal_L10","NA","cellular organisms","Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus"]
["YKL043W","PHD1",6322808,2,4,0,0,"KilA-N","NA","Saccharomycetales","Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate"]
["YKL065C","YET1",6322785,2,4,0,0,"Bap31","NA","Eukaryota","Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein"]
["YKL070W","YKL070W",6322780,2,2,1,0,"FMN_bind_2","NA","cellular organisms","NA"]
["YKL100C","YKL100C",6322749,2,7,1,0,"Peptidase_A22B","NA","Eukaryota","NA"]
["YKL124W","SSH4",6322725,2,6,0,0,"SPRY","NA","Eukaryota","Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases"]
["YKL128C","PMU1",6322721,2,3,0,0,"PGAM","NA","Eukaryota","Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant"]
["YKL165C","MCD4",6322683,2,17,0,0,"Phosphodiest~Sulfatase~PigN","NA","Eukaryota","Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes"]
["YKL188C","PXA2",6322660,2,3,0,0,"ABC_membrane_2~SMC_N~ABC_tran","NA","cellular organisms","Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins"]
["YKL189W","HYM1",6322659,2,3,0,0,"Mo25","NA","Eukaryota","Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response"]
["YKR026C","GCN3",6322878,2,17,0,0,"IF-2B","NA","cellular organisms","Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression"]
["YKR042W","UTH1",81358765,2,13,0,0,"SUN","NA","Eukaryota","Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death"]
["YKR053C","YSR3",6322906,2,8,0,0,"PAP2","NA","cellular organisms","Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p"]
["YKR072C","SIS2",6322925,2,39,0,0,"Flavoprotein","NA","cellular organisms","Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression"]
["YKR084C","HBS1",6322937,2,12,0,0,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~GTP_EFTU_D3","NA","cellular organisms","GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components"]
["YKR102W","FLO10",6322955,2,4,0,0,"PA14~PA14_2","NA","Saccharomyces","Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation"]
["YLL008W","DRS1",6323021,2,3,0,0,"DEAD~Helicase_C","NA","cellular organisms","Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles"]
["YLL011W","SOF1",6323018,2,7,0,0,"WD40~WD40~WD40~WD40~WD40~Sof1","NA","cellular organisms","Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p"]
["YLL031C","GPI13",6322997,2,3,0,0,"Phosphodiest","NA","Eukaryota","ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein"]
["YLR106C","MDN1",6323135,2,5,0,0,"AAA_5~AAA_5~AAA_2~AAA_5~AAA_5~AAA_2~AAA_5~AAA~AAA_3~AAA_5~AAA_5","NA","Eukaryota","Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm"]
["YLR149C","YLR149C",6323178,2,12,1,0,"DUF2415","NA","Dikarya","NA"]
["YLR167W","RPS31",6323196,2,2,0,0,"ubiquitin~Ribosomal_S27~A2L_zn_ribbon","NA","cellular organisms","Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B"]
["YLR192C","HCR1",6323221,2,11,0,0,"eIF3_subunit","NA","Dikarya","Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA"]
["YLR205C","HMX1",42742287,2,7,0,0,"NA","NA","cellular organisms","ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1"]
["YLR209C","PNP1",6323238,2,5,0,0,"PNP_UDP_1","2.4.2.1_Purine-nucleoside phosphorylase","cellular organisms","Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway"]
["YLR213C","CRR1",6323242,2,6,0,0,"Glyco_hydro_16","NA","cellular organisms","Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation"]
["YLR216C","CPR6",6323246,2,15,0,0,"Pro_isomerase~TPR_1~TPR_2","5.2.1.8_Peptidylprolyl isomerase","cellular organisms","Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity"]
["YLR221C","RSA3",6323250,2,8,0,0,"NA","NA","Saccharomycetales","Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus"]
["YLR226W","BUR2",6323255,2,11,0,0,"NA","NA","Saccharomycetales","Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II"]
["YLR227C","ADY4",6323256,2,9,0,0,"NA","NA","Saccharomycetaceae","Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane"]
["YLR293C","GSP1",6323324,2,18,0,0,"Miro~Ras~MMR_HSR1","NA","cellular organisms","GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog"]
["YLR307W","CDA1",6323338,2,8,0,0,"Polysacc_deac_1","3.5.1.41_Chitin deacetylase","cellular organisms","Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall"]
["YLR329W","REC102",85666120,2,4,0,0,"NA","NA","Saccharomycetaceae","Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination"]
["YLR340W","RPP0",6323371,2,6,0,0,"Ribosomal_L10~Ribosomal_60s","NA","cellular organisms","Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302"]
["YLR357W","RSC2",6323389,2,14,0,0,"Bromodomain~Bromodomain~BAH","NA","Fungi/Metazoa group","Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance"]
["YLR375W","STP3",6323406,2,20,0,0,"zf-C2H2","NA","Fungi/Metazoa group","Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids"]
["YLR398C","SKI2",6323430,2,8,0,0,"DEAD~Helicase_C~DSHCT","NA","cellular organisms","Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses"]
["YLR420W","URA4",6323452,2,30,0,0,"Amidohydro_2","3.5.2.3_Dihydroorotase","cellular organisms","Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate"]
["YLR423C","ATG17",6323455,2,15,0,0,"APG17","NA","Ascomycota","Scaffold protein responsible for pre-autophagosomal structure organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity"]
["YLR436C","ECM30",6323468,2,25,0,0,"NA","NA","Saccharomycetaceae","Non-essential protein of unknown function"]
["YLR450W","HMG2",6323483,2,12,0,0,"HMG-CoA_red","NA","cellular organisms","One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks"]
["YML023C","NSE5",6323618,2,3,0,0,"NA","NA","Saccharomycetaceae","Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair"]
["YML031W","NDC1",6323610,2,3,0,0,"Ndc1_Nup","NA","Saccharomycetales","Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II"]
["YML079W","YML079W",6323561,2,2,1,0,"Cupin_5","NA","cellular organisms","NA"]
["YMR084W","YMR084W",6323730,2,8,1,0,"GATase_2","NA","cellular organisms","NA"]
["YMR088C","VBA1",6323735,2,5,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Permease of basic amino acids in the vacuolar membrane"]
["YMR100W","MUB1",6323747,2,10,0,0,"zf-MYND","NA","Dikarya","Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene"]
["YMR107W","SPG4",6323754,2,2,0,0,"NA","NA","Saccharomycetaceae","Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources"]
["YMR112C","MED11",6323759,2,6,0,0,"Med11","NA","Saccharomycetales","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein"]
["YMR125W","STO1",6579194,2,10,0,0,"MIF4G~MIF4G_like~MIF4G_like_2","NA","Eukaryota","Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80"]
["YMR127C","SAS2",6323775,2,18,0,0,"MOZ_SAS","2.3.1.48_Histone acetyltransferase","Eukaryota","Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family"]
["YMR130W","YMR130W",6323778,2,4,1,0,"Hydrolase","NA","cellular organisms","NA"]
["YMR185W","YMR185W",6323839,2,14,1,0,"DUF2411","NA","Dikarya","NA"]
["YMR198W","CIK1",6323854,2,25,0,0,"DHHA2","NA","Saccharomycetaceae","Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p"]
["YMR200W","ROT1",6323856,2,11,0,0,"Rot1","NA","Dikarya","Essential ER membrane protein; may be involved in protein folding; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations"]
["YMR208W","ERG12",6323864,2,4,0,0,"GHMP_kinases_N~GHMP_kinases_C","2.7.1.36_Mevalonate kinase","cellular organisms","Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate"]
["YMR214W","SCJ1",37362683,2,38,0,0,"DnaJ~DnaJ_CXXCXGXG","NA","cellular organisms","One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins"]
["YMR219W","ESC1",6323875,2,5,0,0,"NA","NA","Saccharomyces cerevisiae","Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p"]
["YMR231W","PEP5",6323887,2,11,0,0,"PHD","NA","Eukaryota","Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p"]
["YMR232W","FUS2",6323888,2,9,0,0,"NA","NA","Saccharomycetaceae","Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating"]
["YMR258C","YMR258C",6323914,2,14,1,0,"NA","NA","Saccharomycetales","NA"]
["YMR268C","PRP24",6323924,2,9,0,0,"RRM_1~RRM_1~RRM_1~Lsm_interact","NA","Eukaryota","Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling"]
["YMR275C","BUL1",6323931,2,14,0,0,"Bul1_N~Bul1_C","NA","Saccharomycetales","Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases"]
["YMR311C","GLC8",6323971,2,22,0,0,"NA","NA","Ascomycota","Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2"]
["YMR313C","TGL3",6323973,2,9,0,0,"Patatin","3.1.1.3_Triacylglycerol lipase","cellular organisms","Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes"]
["YNL006W","LST8",6324322,2,5,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat"]
["YNL024C","YNL024C",6324304,2,2,1,0,"Methyltransf_16","NA","Eukaryota","NA"]
["YNL026W","SAM50",6324302,2,8,0,0,"Bac_surface_Ag","NA","cellular organisms","Essential component of the Sorting and Assembly Machinery (SAM or Tob complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85"]
["YNL031C","HHT2",6324297,2,4,0,0,"Histone","NA","Eukaryota","One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation"]
["YNL046W","YNL046W",6324282,2,5,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YNL072W","RNH201",6324257,2,4,0,0,"RNase_HII","NA","cellular organisms","Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease; homolog of mammalian RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1)"]
["YNL106C","INP52",6324224,2,12,0,0,"Syja_N~Exo_endo_phos","NA","Eukaryota","Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain"]
["YNL112W","DBP2",6324217,2,4,0,0,"DEAD~Helicase_C","NA","cellular organisms","Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing"]
["YNL124W","NAF1",6324205,2,3,0,0,"NAF1","NA","Eukaryota","Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins"]
["YNL127W","FAR11",6324202,2,10,0,0,"N1221","NA","Fungi/Metazoa group","Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p"]
["YNL129W","NRK1",6324200,2,3,0,0,"NA","2.7.1.22_Ribosylnicotinamide kinase","cellular organisms","Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis"]
["YNL141W","AAH1",6324188,2,6,0,0,"A_deaminase","3.5.4.4_Adenosine deaminase","cellular organisms","Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome"]
["YNL145W","MFA2",6324184,2,7,0,0,"DUF567","NA","Saccharomycetaceae","Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1"]
["YNL181W","YNL181W",6324148,2,5,1,0,"NA","NA","cellular organisms","NA"]
["YNL220W","ADE12",6324109,2,5,0,0,"Adenylsucc_synt","6.3.4.4_Adenylosuccinate synthase","cellular organisms","Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence"]
["YNL227C","JJJ1",6324103,2,10,0,0,"DnaJ~zf-C2H2","NA","Eukaryota","Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis"]
["YNL282W","POP3",6324047,2,10,0,0,"RNase_P_pop3","NA","Saccharomycetales","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"]
["YNL304W","YPT11",82795261,2,9,0,0,"Ras~Miro~Ras","NA","cellular organisms","Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells"]
["YNL331C","AAD14",6323998,2,14,0,0,"Aldo_ket_red","NA","cellular organisms","Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role"]
["YNR003C","RPC34",6324330,2,3,0,0,"RNA_pol_Rpc34","NA","Eukaryota","RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex"]
["YNR027W","BUD17",6324354,2,8,0,0,"PfkB~Phos_pyr_kin","NA","cellular organisms","Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YNR035C","ARC35",6324363,2,15,0,0,"P34-Arc","NA","Eukaryota","Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin"]
["YNR049C","MSO1",6324377,2,16,0,0,"NA","NA","Saccharomycetaceae","Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions; required for sporulation"]
["YOL011W","PLB3",6324563,2,5,0,0,"PLA2_B","3.1.1.5_Lysophospholipase","Fungi/Metazoa group","Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro"]
["YOL065C","INP54",6324507,2,12,0,0,"Exo_endo_phos","NA","Eukaryota","Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins"]
["YOL066C","RIB2",6324506,2,5,0,0,"PseudoU_synth_2~dCMP_cyt_deam_1","NA","cellular organisms","DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; cytoplasmic tRNA pseudouridine synthase involved in pseudouridylation of cytoplasmic tRNAs at position 32"]
["YOL093W","TRM10",6324479,2,13,0,0,"tRNA_m1G_MT","NA","Eukaryota","tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs"]
["YOL101C","IZH4",6324471,2,9,0,0,"HlyIII","NA","Fungi/Metazoa group","Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism"]
["YOL109W","ZEO1",6324463,2,12,0,0,"Apolipoprotein","NA","Saccharomyces cerevisiae","Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria"]
["YOL114C","YOL114C",6324458,2,5,1,0,"RF-1","NA","cellular organisms","NA"]
["YOR014W","RTS1",6324588,2,16,0,0,"B56~B56","NA","Eukaryota","B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A"]
["YOR057W","SGT1",6324631,2,2,0,0,"CS~SGS","NA","Eukaryota","Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex"]
["YOR063W","RPL3",6324637,2,4,0,0,"Ribosomal_L3","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus"]
["YOR070C","GYP1",6324644,2,53,0,0,"TBC","NA","Eukaryota","Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion"]
["YOR075W","UFE1",6324649,2,3,0,0,"Syntaxin-18_N","NA","Fungi/Metazoa group","t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex"]
["YOR076C","SKI7",6324650,2,7,0,0,"GTP_EFTU","NA","cellular organisms","Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs"]
["YOR123C","LEO1",6324697,2,16,0,0,"Leo1","NA","Eukaryota","Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition"]
["YOR131C","YOR131C",6324705,2,11,1,0,"Hydrolase","NA","cellular organisms","NA"]
["YOR141C","ARP8",6324715,2,11,0,0,"Actin","NA","Eukaryota","Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"]
["YOR153W","PDR5",6324727,2,44,0,0,"ABC_tran~ABC2_membrane~PDR_CDR~ABC_tran~ABC2_membrane","NA","cellular organisms","Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth"]
["YOR198C","BFR1",6324772,2,13,0,0,"NA","NA","Dikarya","Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity"]
["YOR217W","RFC1",6324791,2,3,0,0,"BRCT~AAA~RFC1","NA","cellular organisms","Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"]
["YOR234C","RPL33B",6324808,2,2,0,0,"Ribosomal_L35Ae","NA","cellular organisms","Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable"]
["YOR245C","DGA1",6324819,2,8,0,0,"DAGAT~DAGAT","2.3.1.20_Diacylglycerol O-acyltransferase","cellular organisms","Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles"]
["YOR256C","TRE2",6324830,2,15,0,0,"PA~TFR_dimer","NA","cellular organisms","Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31"]
["YOR278W","HEM4",6324852,2,3,0,0,"HEM4","4.2.1.75_Uroporphyrinogen-III synthase","cellular organisms","Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway"]
["YOR294W","RRS1",6324868,2,2,0,0,"RRS1","NA","Eukaryota","Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice"]
["YOR310C","NOP58",6324886,2,4,0,0,"NOP5NT~NOSIC~Nop","NA","cellular organisms","Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA"]
["YOR311C","HSD1",6324887,2,9,0,0,"CTP_transf_1","NA","cellular organisms","Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain"]
["YOR363C","PIP2",6324939,2,3,0,0,"Zn_clus","NA","Saccharomycetales","Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes"]
["YPL017C","IRC15",6325240,2,19,0,0,"FAD_binding_2~Pyr_redox_2~Pyr_redox~Pyr_redox_dim","NA","cellular organisms","Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci"]
["YPL018W","CTF19",6325239,2,5,0,0,"NA","NA","Saccharomycetaceae","Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly"]
["YPL026C","SKS1",6325231,2,3,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway"]
["YPL034W","YPL034W",6325222,2,8,1,0,"NA","NA","Saccharomycetales","NA"]
["YPL055C","LGE1",6325202,2,31,0,0,"NA","NA","Saccharomycetaceae","Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division"]
["YPL068C","YPL068C",6325189,2,8,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL095C","EEB1",6325162,2,8,0,0,"Abhydrolase_1","NA","cellular organisms","Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification"]
["YPL128C","TBF1",6325129,2,10,0,0,"Myb_DNA-binding","NA","Ascomycota","Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation"]
["YPL132W","COX11",6325125,2,7,0,0,"CtaG_Cox11","NA","cellular organisms","Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p"]
["YPL174C","NIP100",6325083,2,12,0,0,"CAP_GLY","NA","Saccharomycetales","Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)"]
["YPL184C","MRN1",6325072,2,25,0,0,"RRM_1","NA","Eukaryota","Putative RNA binding protein"]
["YPL214C","THI6",6325042,2,9,0,0,"TMP-TENI~HK","2.5.1.3_Thiamine-phosphate diphosphorylase|2.7.1.50_Hydroxyethylthiazole kinase","cellular organisms","Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YPL223C","GRE1",6325033,2,7,0,0,"NA","NA","Saccharomyces cerevisiae","Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway"]
["YPL229W","YPL229W",6325027,2,5,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPL256C","CLN2",6324999,2,19,0,0,"Cyclin_N","NA","Dikarya","G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)"]
["YPL263C","KEL3",6324992,2,3,0,0,"Kelch_1~Kelch_2~Kelch_2","NA","cellular organisms","Cytoplasmic protein of unknown function"]
["YPR033C","HTS1",6325290,2,5,0,0,"tRNA-synt_2b~HGTP_anticodon","6.1.1.21_Histidine--tRNA ligase","cellular organisms","Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence"]
["YPR037C","ERV2",6325296,2,10,0,0,"Evr1_Alr","1.8.3.2_Thiol oxidase","Eukaryota","Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER"]
["YPR058W","YMC1",6325315,2,5,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p"]
["YPR065W","ROX1",6325322,2,22,0,0,"HMG_box","NA","Fungi/Metazoa group","Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity"]
["YPR074C","TKL1",6325331,2,39,0,0,"Transketolase_N~Transket_pyr~Transketolase_C","2.2.1.1_Transketolase","cellular organisms","Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids"]
["YPR094W","RDS3",6325351,2,2,0,0,"PHF5","NA","Eukaryota","Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance"]
["YPR104C","FHL1",6325361,2,4,0,0,"FHA~Fork_head","NA","Ascomycota","Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4"]
["YPR107C","YTH1",6325364,2,12,0,0,"zf-CCCH~zf-CCCH~zf-CCCH","NA","Eukaryota","Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation"]
["YPR109W","YPR109W",6325366,2,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YPR117W","YPR117W",6325374,2,2,1,0,"DUF2405~Fmp27_SW~Fmp27_GFWDK~Fmp27_WPPW~Apt1","NA","Fungi/Metazoa group","NA"]
["YPR122W","AXL1",6325379,2,6,0,0,"Peptidase_M16","NA","cellular organisms","Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells"]
["YPR129W","SCD6",6325386,2,7,0,0,"DFDF~FFD_TFG","NA","Eukaryota","Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin"]
["YPR148C","YPR148C",6325406,2,3,0,0,"BAR_2~RXT2_N","NA","Dikarya","NA"]
["YPR160W","GPH1",6325418,2,12,0,0,"Phosphorylase","2.4.1.1_Phosphorylase","cellular organisms","Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway"]
["YPR167C","MET16",6325425,2,10,0,0,"PAPS_reduct","NA","cellular organisms","3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism"]
["YPR168W","NUT2",6325426,2,2,0,0,"Med10","NA","Eukaryota","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription"]
["YPR172W","YPR172W",6325430,2,5,1,0,"Pyridox_oxidase","NA","cellular organisms","NA"]
["YPR185W","ATG13",6325443,2,2,0,0,"ATG13","NA","Ascomycota","Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling"]
["YPR190C","RPC82",6325448,2,4,0,0,"HTH_9~RNA_pol_Rpc82","NA","Dikarya","RNA polymerase III subunit C82"]
["YPR192W","AQY1",6325450,2,8,0,0,"MIP","NA","cellular organisms","Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance"]
["YAL039C","CYC3",6319278,2,3,0,1,"Cyto_heme_lyase","4.4.1.17_Holocytochrome-c synthase","Eukaryota","Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)"]
["YCR046C","IMG1",6319894,2,14,0,1,"NA","NA","Eukaryota","Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome"]
["YDR070C","FMP16",6320275,2,5,1,1,"NA","NA","Saccharomycetaceae","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YDR376W","ARH1",6320584,2,2,0,1,"NA","1.18.1.2_Ferredoxin--NADP(+) reductase","cellular organisms","Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability"]
["YDR462W","MRPL28",6320670,2,16,0,1,"MRP-L28","NA","Dikarya","Mitochondrial ribosomal protein of the large subunit"]
["YDR514C","YDR514C",6320722,2,2,1,1,"NA","NA","Dikarya","NA"]
["YER048W-A","ISD11",6320889,2,3,0,1,"Complex1_LYR","NA","Eukaryota","Protein required for mitochondrial iron-sulfur cluster biosynthesis"]
["YER073W","ALD5",6320917,2,9,0,1,"Aldedh","NA","cellular organisms","Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed"]
["YGL057C","YGL057C",6321381,2,8,1,1,"NA","NA","Saccharomycetaceae","NA"]
["YGR076C","MRPL25",6321513,2,4,0,1,"NA","NA","Ascomycota","Mitochondrial ribosomal protein of the large subunit"]
["YGR112W","SHY1",6321550,2,16,0,1,"SURF1","NA","cellular organisms","Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome"]
["YGR255C","COQ6",6321694,2,24,0,1,"FAD_binding_3~Thi4~FAD_binding_2~Lycopene_cycl~Pyr_redox_2~FAD_binding_3","NA","cellular organisms","Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes"]
["YHR008C","SOD2",6321796,2,15,0,1,"Sod_Fe_N~Sod_Fe_C","1.15.1.1_Superoxide dismutase","cellular organisms","Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated"]
["YHR011W","DIA4",6321799,2,38,0,1,"tRNA-synt_2b","6.1.1.11_Serine--tRNA ligase","cellular organisms","Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth"]
["YHR024C","MAS2",6321813,2,3,0,1,"Peptidase_M16~Peptidase_M16_C","3.4.24.64_Mitochondrial processing peptidase","cellular organisms","Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins"]
["YHR051W","COX6",6321842,2,11,0,1,"COX5A~DUF488","1.9.3.1_Cytochrome-c oxidase","Fungi/Metazoa group","Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels"]
["YHR059W","FYV4",6321850,2,9,0,1,"IGR","NA","Ascomycota","Protein of unknown function, required for survival upon exposure to K1 killer toxin"]
["YHR117W","TOM71",6321909,2,24,0,1,"TPR_1~TPR_2~TPR_1~TPR_2","NA","cellular organisms","Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins"]
["YHR162W","YHR162W",6321956,2,4,1,1,"UPF0041","NA","Eukaryota","NA"]
["YIL136W","OM45",6322055,2,10,0,1,"NA","NA","Saccharomycetaceae","Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane"]
["YJL054W","TIM54",6322407,2,21,0,1,"NA","NA","Dikarya","Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane"]
["YJL209W","CBP1",6322252,2,10,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p"]
["YKL016C","ATP7",6322836,2,6,0,1,"Mt_ATP-synt_D","NA","Fungi/Metazoa group","Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YKL134C","2009-10-01",6322715,2,9,0,1,"Peptidase_M3","3.4.24.59_Mitochondrial intermediate peptidase","cellular organisms","Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis"]
["YLR072W","YLR072W",6323101,2,10,1,1,"GRAM","NA","Eukaryota","NA"]
["YLR351C","NIT3",6323383,2,5,0,1,"CN_hydrolase","NA","cellular organisms","Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member"]
["YMR257C","PET111",6323913,2,5,0,1,"NA","NA","Saccharomycetaceae","Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane"]
["YNL003C","PET8",6324325,2,8,0,1,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth"]
["YNL104C","LEU4",6324225,2,8,0,1,"HMGL-like~LeuA_dimer","2.3.3.13_2-isopropylmalate synthase","cellular organisms","Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway"]
["YNL169C","PSD1",6324160,2,5,0,1,"PS_Dcarbxylase~PS_Dcarbxylase~Peptidase_M23","4.1.1.65_Phosphatidylserine decarboxylase","cellular organisms","Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine"]
["YNL284C","MRPL10",6324045,2,11,0,1,"Ribosomal_L15~L15","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels"]
["YNR018W","AIM38",6324345,2,4,1,1,"NA","NA","Dikarya","Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YOR040W","GLO4",6324614,2,6,0,1,"Lactamase_B","3.1.2.6_Hydroxyacylglutathione hydrolase","cellular organisms","Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate"]
["YOR142W","LSC1",6324716,2,6,0,1,"CoA_binding~Ligase_CoA","6.2.1.5_Succinate--CoA ligase (ADP-forming)","cellular organisms","Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated"]
["YPL172C","COX10",6325085,2,9,0,1,"UbiA","NA","cellular organisms","Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders"]
["YAL001C","TFC3",6319317,1,3,0,0,"B-block_TFIIIC","NA","Ascomycota","Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding"]
["YAL009W","SPO7",6319310,1,26,0,0,"Spo7","NA","Eukaryota","Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation"]
["YAL012W","CYS3",6319307,1,11,0,0,"Cys_Met_Meta_PP","4.4.1.1_Cystathionine gamma-lyase","cellular organisms","Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine"]
["YAL023C","PMT2",27469358,1,15,0,0,"PMT~MIR","2.4.1.109_Dolichyl-phosphate-mannose-protein mannosyltransferase","cellular organisms","Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals"]
["YAL024C","LTE1",6319295,1,45,0,0,"RasGEF_N~RasGEF","NA","Saccharomycetales","Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP"]
["YAL026C","DRS2",6319293,1,37,0,0,"E1-E2_ATPase~Hydrolase","3.6.3.1_Phospholipid-translocating ATPase","cellular organisms","Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease"]
["YAL035W","FUN12",6319282,1,29,0,0,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~GTP_EFTU_D2","NA","cellular organisms","GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2"]
["YAL051W","OAF1",50593114,1,4,0,0,"Zn_clus~Fungal_trans","NA","Saccharomycetales","Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis"]
["YAL059W","ECM1",6319259,1,8,0,0,"NA","NA","Saccharomycetales","Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export"]
["YAR008W","SEN34",6319322,1,5,0,0,"tRNA_int_endo","NA","cellular organisms","Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease"]
["YAR018C","KIN3",6319327,1,23,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Nonessential protein kinase with unknown cellular role"]
["YBL011W","SCT1",6319459,1,13,0,0,"Acyltransferase","2.3.1.15_Glycerol-3-phosphate O-acyltransferase|2.3.1.42_Glycerone-phosphate O-acyltransferase","cellular organisms","Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed"]
["YBL027W","RPL19B",6319444,1,13,0,0,"Ribosomal_L19e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal"]
["YBL087C","RPL23A",6319384,1,5,0,0,"Ribosomal_L14","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins"]
["YBL088C","TEL1",6319383,1,9,0,0,"PI3_PI4_kinase~FATC","2.7.11.1_Non-specific serine/threonine protein kinase","Fungi/Metazoa group","Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene"]
["YBR004C","GPI18",6319476,1,2,0,0,"Mannosyl_trans2","NA","Eukaryota","Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria"]
["YBR036C","CSG2",6319510,1,41,0,0,"NA","NA","Saccharomycetaceae","Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations"]
["YBR076W","ECM8",6319550,1,4,0,0,"NA","NA","Saccharomycetaceae","Non-essential protein of unknown function"]
["YBR084C-A","RPL19A",6319559,1,4,0,0,"Ribosomal_L19e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal"]
["YBR086C","IST2",27808701,1,8,0,0,"DUF590","NA","Fungi/Metazoa group","Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process"]
["YBR087W","RFC5",6319562,1,2,0,0,"RFC-E_C","NA","cellular organisms","Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"]
["YBR109C","CMD1",6319585,1,15,0,0,"efhand~efhand~efhand","NA","cellular organisms","Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin"]
["YBR146W","MRPS9",6319622,1,7,0,0,"Ribosomal_S9","NA","cellular organisms","Mitochondrial ribosomal protein of the small subunit"]
["YBR152W","SPP381",6319628,1,2,0,0,"NA","NA","Saccharomycetaceae","mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p"]
["YBR155W","CNS1",6319631,1,4,0,0,"TPR_1~TPR_2","NA","Eukaryota","TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion"]
["YBR167C","POP7",6319644,1,3,0,0,"NA","3.1.26.5_Ribonuclease P","Ascomycota","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends"]
["YBR168W","PEX32",6319645,1,10,0,0,"Pex24p","NA","Ascomycota","Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p"]
["YBR169C","SSE2",6319646,1,7,0,0,"HSP70","NA","cellular organisms","Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p"]
["YBR170C","NPL4",6319647,1,2,0,0,"zf-NPL4~NPL4","NA","Eukaryota","Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation"]
["YBR175W","SWD3",6319651,1,18,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5"]
["YBR197C","YBR197C",6319674,1,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YBR200W","BEM1",6319677,1,26,0,0,"SH3_1~SH3_1~PX~PB1","NA","Fungi/Metazoa group","Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p"]
["YBR207W","FTH1",6319684,1,8,0,0,"FTR1","NA","cellular organisms","Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis"]
["YBR235W","YBR235W",6319712,1,9,1,0,"AA_permease~AA_permease","NA","cellular organisms","NA"]
["YBR247C","ENP1",6319724,1,2,0,0,"Bystin","NA","Eukaryota","Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus"]
["YBR249C","ARO4",6319726,1,11,0,0,"DAHP_synth_1","2.5.1.54_3-deoxy-7-phosphoheptulonate synthase","cellular organisms","3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan"]
["YCL026C-A","FRM2",10383765,1,7,0,0,"Nitroreductase","NA","cellular organisms","Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases"]
["YCL027W","FUS1",10383763,1,3,0,0,"SH3_1~SH3_2","NA","Saccharomycetaceae","Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate"]
["YCL034W","LSB5",10383760,1,3,0,0,"NA","NA","Dikarya","Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"]
["YCL054W","SPB1",6319796,1,2,0,0,"FtsJ~Spb1_C","NA","Eukaryota","AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants"]
["YCR031C","RPS14A",10383793,1,2,0,0,"Ribosomal_S11","NA","cellular organisms","Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins"]
["YCR034W","FEN1",6319882,1,19,0,0,"ELO","NA","Eukaryota","Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway"]
["YCR036W","RBK1",10383797,1,10,0,0,"PfkB~PfkB","2.7.1.15_Ribokinase","cellular organisms","Putative ribokinase"]
["YCR084C","TUP1",6319926,1,40,0,0,"Tup_N~WD40~WD40~WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes"]
["YDL005C","MED2",6320199,1,11,0,0,"NA","NA","Saccharomycetaceae","Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YDL013W","SLX5",6320191,1,10,0,0,"NA","NA","Saccharomycetales","Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate"]
["YDL035C","GPR1",6320170,1,4,0,0,"NA","NA","Ascomycota","Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis"]
["YDL055C","PSA1",6320148,1,2,0,0,"NTP_transferase~CTP_transf_3~Hexapep","2.7.7.13_Mannose-1-phosphate guanylyltransferase","cellular organisms","GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure"]
["YDL102W","POL3",6320101,1,3,0,0,"DNA_pol_B_exo~DNA_pol_B","2.7.7.7_DNA-directed DNA polymerase","cellular organisms","Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)"]
["YDL117W","CYK3",6320086,1,14,0,0,"SH3_1","NA","Ascomycota","SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis"]
["YDL122W","UBP1",6320081,1,4,0,0,"UCH","3.1.2.15_Ubiquitin thiolesterase","Fungi/Metazoa group","Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains"]
["YDL146W","LDB17",6320055,1,16,0,0,"DUF2013","NA","Fungi/Metazoa group","Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface"]
["YDL165W","CDC36",6320036,1,8,0,0,"NOT2_3_5","NA","Eukaryota","Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor"]
["YDL173W","YDL173W",6320028,1,34,1,0,"NA","NA","Saccharomycetales","NA"]
["YDL175C","AIR2",6320026,1,5,0,0,"zf-CCHC~zf-CCHC~zf-CCHC","NA","Eukaryota","RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p"]
["YDL192W","ARF1",6320009,1,39,0,0,"Arf~SRPRB~Miro~SRP54","NA","cellular organisms","ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p"]
["YDL194W","SNF3",6320007,1,11,0,0,"Sugar_tr~MFS_1","NA","cellular organisms","Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4"]
["YDL197C","ASF2",6320004,1,8,0,0,"NA","NA","Saccharomyces cerevisiae","Anti-silencing protein that causes derepression of silent loci when overexpressed"]
["YDL199C","YDL199C",6320002,1,9,1,0,"Sugar_tr~MFS_1","NA","cellular organisms","NA"]
["YDL201W","TRM8",6320000,1,3,0,0,"Methyltransf_4","2.1.1.33_tRNA (guanine-N(7)-)-methyltransferase","cellular organisms","Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA"]
["YDL226C","GCS1",6319975,1,21,0,0,"ArfGap","NA","Eukaryota","ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p"]
["YDL237W","LRC1",6319964,1,8,1,0,"NA","NA","cellular organisms","Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media"]
["YDR020C","DAS2",6320223,1,12,1,0,"NA","NA","cellular organisms","Predicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null mutant suppresses dst1delta sensitivity for 6-azauracil"]
["YDR046C","BAP3",6320251,1,3,0,0,"AA_permease","NA","cellular organisms","Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine"]
["YDR047W","HEM12",6320252,1,5,0,0,"URO-D","4.1.1.37_Uroporphyrinogen decarboxylase","cellular organisms","Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents"]
["YDR096W","GIS1",6320301,1,14,0,0,"JmjN~JmjC~zf-C2H2~zf-C2H2","NA","Eukaryota","JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1"]
["YDR114C","YDR114C",6320320,1,3,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YDR144C","MKC7",6320348,1,14,0,0,"Asp","3.4.23.41_Yapsin 1","Eukaryota","GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p"]
["YDR145W","TAF12",6320349,1,11,0,0,"TFIID_20kDa","NA","Eukaryota","Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A"]
["YDR147W","EKI1",6320351,1,4,0,0,"Choline_kin_N~Choline_kinase~APH","2.7.1.82_Ethanolamine kinase","cellular organisms","Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway"]
["YDR162C","NBP2",6320366,1,27,0,0,"SH3_1~SH3_2","NA","Ascomycota","Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p"]
["YDR181C","SAS4",6320387,1,13,0,0,"NA","NA","Saccharomycetales","Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p"]
["YDR186C","YDR186C",6320392,1,7,0,0,"NA","NA","Saccharomycetaceae","NA"]
["YDR200C","VPS64",6320406,1,10,0,0,"FHA","NA","Saccharomycetales","Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane"]
["YDR233C","RTN1",6320439,1,12,0,0,"Reticulon","NA","Eukaryota","ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; also interacts with Sbh1p; null mutant has an altered (mostly cisternal) ER morphology; member of the RTNLA (reticulon-like A) subfamily"]
["YDR247W","VHS1",6320453,1,12,0,0,"Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p"]
["YDR276C","PMP3",6320482,1,30,0,0,"UPF0057","NA","cellular organisms","Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential"]
["YDR297W","SUR2",6320503,1,15,0,0,"FA_hydroxylase","NA","cellular organisms","Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis"]
["YDR300C","PRO1",6320506,1,36,0,0,"AA_kinase~PUA","2.7.2.11_Glutamate 5-kinase","cellular organisms","Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis"]
["YDR335W","MSN5",6320542,1,30,0,0,"NA","NA","Eukaryota","Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP"]
["YDR349C","YPS7",6320556,1,16,0,0,"Asp","NA","Fungi/Metazoa group","Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum"]
["YDR356W","SPC110",6320562,1,6,0,0,"NA","NA","cellular organisms","Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner"]
["YDR365C","ESF1",6320573,1,4,0,0,"NUC153","NA","Eukaryota","Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels"]
["YDR371W","CTS2",6320579,1,5,1,0,"Glyco_hydro_18","3.2.1.14_Chitinase","cellular organisms","Sporulation-specific chitinase"]
["YDR379W","RGA2",6320587,1,5,0,0,"LIM~RhoGAP","NA","Eukaryota","GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p"]
["YDR385W","EFT2",6320593,1,12,0,0,"GTP_EFTU~MMR_HSR1~GTP_EFTU_D2~EFG_IV~EFG_C","NA","cellular organisms","Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin"]
["YDR394W","RPT3",6320602,1,7,0,0,"NACHT~Parvo_NS1~AAA~AAA_3~AAA_5~AAA_2~ATP-synt_ab~Mg_chelatase","NA","cellular organisms","One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B"]
["YDR402C","DIT2",6320610,1,9,0,0,"p450~p450","NA","cellular organisms","N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s"]
["YDR416W","SYF1",6320624,1,5,0,0,"NA","NA","Eukaryota","Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein"]
["YDR457W","TOM1",6320665,1,5,0,0,"DUF908~DUF913~HECT","NA","Eukaryota","E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators"]
["YDR464W","SPP41",6320672,1,2,0,0,"NA","NA","Saccharomycetaceae","Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3"]
["YDR473C","PRP3",6320681,1,4,0,0,"PRP3","NA","Eukaryota","Splicing factor, component of the U4/U6-U5 snRNP complex"]
["YDR487C","RIB3",6320695,1,2,0,0,"DHBP_synthase","4.1.99.12_3,4-dihydroxy-2-butanone-4-phosphate synthase","cellular organisms","3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration"]
["YDR536W","STL1",6320745,1,11,0,0,"MFS_1~Sugar_tr","NA","cellular organisms","Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock"]
["YEL017C-A","PMP2",6320819,1,4,0,0,"PMP1_2","NA","Saccharomycetaceae","Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1"]
["YEL031W","SPF1",6320804,1,32,0,0,"E1-E2_ATPase~Hydrolase~Hydrolase","NA","cellular organisms","P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1"]
["YEL034W","HYP2",6320801,1,6,0,0,"KOW~eIF-5a","NA","cellular organisms","Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; possible role in translation elongation; undergoes an essential hypusination modification"]
["YEL038W","UTR4",99030924,1,6,0,0,"Hydrolase","NA","cellular organisms","Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus"]
["YEL062W","NPR2",37362640,1,30,0,0,"NPR2~NPR2~NPR2","NA","Eukaryota","Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin"]
["YER002W","NOP16",6320838,1,5,0,0,"Nop16","NA","Dikarya","Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis"]
["YER025W","GCD11",6320863,1,4,0,0,"GTP_EFTU~GTP_EFTU_D2~eIF2_C","NA","cellular organisms","Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met"]
["YER031C","YPT31",6320869,1,39,0,0,"Miro~Ras","NA","cellular organisms","GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi"]
["YER040W","GLN3",6320879,1,10,0,0,"GATA","NA","Saccharomycetaceae","Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source"]
["YER111C","SWI4",6320957,1,10,0,0,"KilA-N~Ank~Ank","NA","Dikarya","DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair"]
["YER165W","PAB1",6321013,1,6,0,0,"RRM_1~RRM_1~RRM_1~RRM_1~PABP","NA","cellular organisms","Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G"]
["YFL024C","EPL1",14318495,1,4,0,0,"EPL1","NA","Fungi/Metazoa group","Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb"]
["YFR003C","YPI1",14318525,1,5,0,0,"PPI_Ypi1","NA","Eukaryota","Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen"]
["YFR008W","FAR7",14318530,1,10,0,0,"NA","NA","Saccharomycetaceae","Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p"]
["YFR036W","CDC26",14318561,1,12,0,0,"NA","NA","Saccharomyces cerevisiae","Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"]
["YFR048W","RMD8",22532998,1,9,0,0,"DUF155","NA","cellular organisms","Cytosolic protein required for sporulation"]
["YFR053C","HXK1",14318578,1,5,0,0,"Hexokinase_1~Hexokinase_2","2.7.1.1_Hexokinase","cellular organisms","Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p"]
["YGL019W","CKB1",6321419,1,33,0,0,"CK_II_beta","NA","Eukaryota","Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases"]
["YGL023C","PIB2",6321415,1,4,0,0,"FYVE","NA","Ascomycota","Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27"]
["YGL026C","TRP5",6321412,1,29,0,0,"Trp_syntA~PALP","4.2.1.20_Tryptophan synthase","cellular organisms","Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis"]
["YGL065C","ALG2",6321373,1,4,0,0,"Glycos_transf_1","NA","cellular organisms","Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol"]
["YGL091C","NBP35",6321347,1,4,0,0,"ArsA_ATPase~CbiA~ParA","NA","cellular organisms","Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases"]
["YGL154C","LYS5",6321284,1,4,0,0,"ACPS","NA","cellular organisms","Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine"]
["YGL167C","PMR1",6321271,1,11,0,0,"Cation_ATPase_N~E1-E2_ATPase~Hydrolase~Cation_ATPase_C","3.6.3.8_Calcium-transporting ATPase","cellular organisms","High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease"]
["YGL220W","AIM15",6321218,1,3,0,0,"BolA","NA","cellular organisms","Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel"]
["YGL229C","SAP4",6321208,1,2,0,0,"SAPS","NA","Eukaryota","Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p"]
["YGL232W","TAN1",6321205,1,11,0,0,"THUMP","NA","Eukaryota","Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA"]
["YGR004W","PEX31",6321441,1,11,0,0,"Pex24p","NA","Dikarya","Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p"]
["YGR007W","MUQ1",6321444,1,8,0,0,"CTP_transf_2~CTP_transf_2","2.7.7.14_Ethanolamine-phosphate cytidylyltransferase","cellular organisms","Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases"]
["YGR014W","MSB2",6321451,1,1,0,0,"NA","NA","Ascomycota","Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate"]
["YGR027C","RPS25A",6321464,1,10,0,0,"Ribosomal_S25~EAP30","NA","Eukaryota","Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein"]
["YGR042W","YGR042W",6321479,1,5,1,0,"DUF2439","NA","Ascomycota","NA"]
["YGR055W","MUP1",6321492,1,20,0,0,"NA","NA","cellular organisms","High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake"]
["YGR058W","PEF1",6321495,1,14,0,0,"NA","NA","Eukaryota","Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2"]
["YGR059W","SPR3",6321496,1,4,0,0,"Septin~Fmp27_WPPW","NA","Eukaryota","Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI"]
["YGR086C","PIL1",6321523,1,6,0,0,"NA","NA","Dikarya","Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria"]
["YGR088W","CTT1",86559466,1,8,0,0,"Catalase~Catalase-rel","1.11.1.6_Catalase","cellular organisms","Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide"]
["YGR110W","YGR110W",6321548,1,2,1,0,"Abhydrolase_1","NA","cellular organisms","NA"]
["YGR141W","VPS62",6321580,1,5,0,0,"NA","NA","cellular organisms","Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins"]
["YGR148C","RPL24B",6321587,1,4,0,0,"Ribosomal_L24e","NA","cellular organisms","Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"]
["YGR162W","TIF4631",6321601,1,13,0,0,"MIF4G","NA","Eukaryota","Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p"]
["YGR175C","ERG1",6321614,1,5,0,0,"DAO~SE","1.14.99.7_Squalene monooxygenase","cellular organisms","Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine"]
["YGR181W","TIM13",6321620,1,15,0,0,"zf-Tim10_DDP","NA","Eukaryota","Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner"]
["YGR191W","HIP1",6321629,1,7,0,0,"AA_permease","NA","cellular organisms","High-affinity histidine permease, also involved in the transport of manganese ions"]
["YGR204W","ADE3",6321643,1,5,0,0,"THF_DHG_CYH~THF_DHG_CYH_C~FTHFS","1.5.1.5_Methylenetetrahydrofolate dehydrogenase (NADP(+))|3.5.4.9_Methenyltetrahydrofolate cyclohydrolase|6.3.4.3_Formate--tetrahydrofolate ligase","cellular organisms","Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine"]
["YGR217W","CCH1",6321656,1,5,0,0,"Ion_trans~Ion_trans~Ion_trans~Ion_trans","NA","Eukaryota","Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together"]
["YGR225W","AMA1",83578100,1,8,0,0,"NA","NA","cellular organisms","Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis"]
["YGR264C","MES1",6321704,1,3,0,0,"MetRS-N~tRNA-synt_1g","6.1.1.10_Methionine--tRNA ligase","cellular organisms","Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs"]
["YHR022C","YHR022C",6321811,1,16,1,0,"Miro~Miro~MMR_HSR1~Ras~GTP_EFTU","NA","Eukaryota","NA"]
["YHR029C","YHI9",6321818,1,11,0,0,"PhzC-PhzF","NA","cellular organisms","Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production"]
["YHR030C","SLT2",6321819,1,55,0,0,"Pkinase~Pkinase_Tyr~Pkinase_Tyr","2.7.11.24_Mitogen-activated protein kinase","cellular organisms","Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway"]
["YHR084W","STE12",6321876,1,5,0,0,"STE","NA","Saccharomycetales","Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth"]
["YHR114W","BZZ1",6321906,1,6,0,0,"FCH~SH3_1~SH3_2~SH3_1~SH3_2","NA","Eukaryota","SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins"]
["YHR164C","DNA2",6321958,1,7,0,0,"Dna2~MobB","NA","cellular organisms","Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate"]
["YHR181W","SVP26",6321975,1,10,0,0,"Erv26","NA","Eukaryota","Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment"]
["YHR195W","NVJ1",6321989,1,14,0,0,"NA","NA","Saccharomycetaceae","Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)"]
["YHR196W","UTP9",6321990,1,2,0,0,"NA","NA","Saccharomycetales","Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"]
["YIL021W","RPB3",6322168,1,5,0,0,"RNA_pol_L~RNA_pol_A_bac","NA","cellular organisms","RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit"]
["YIL038C","NOT3",6322151,1,7,0,0,"Not3~NOT2_3_5","NA","Eukaryota","Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation"]
["YIL047C","SYG1",6322142,1,13,0,0,"SPX~EXS","NA","Eukaryota","Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency"]
["YIL061C","SNP1",6322128,1,4,0,0,"RRM_1","NA","cellular organisms","Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein"]
["YIL062C","ARC15",6322127,1,3,0,0,"P16-Arc","NA","Eukaryota","Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"]
["YIL069C","RPS24B",6322120,1,8,0,0,"Ribosomal_S24e","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein"]
["YIL075C","RPN2",6322115,1,4,0,0,"PC_rep~PC_rep~PC_rep~PC_rep","NA","Eukaryota","Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p"]
["YIL109C","SEC24",6322082,1,8,0,0,"zf-Sec23_Sec24~Sec23_trunk~Sec23_BS~Sec23_helical~Gelsolin","NA","Eukaryota","Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p"]
["YIL129C","TAO3",6322062,1,9,0,0,"NA","NA","Eukaryota","Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p; mutants activate OCH1 transcription"]
["YIL134W","FLX1",6322057,1,9,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane"]
["YIL139C","REV7",6322052,1,4,0,0,"HORMA","NA","Ascomycota","Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage"]
["YIL153W","RRD1",6322038,1,38,0,0,"PTPA","NA","Eukaryota","Peptidyl-prolyl cis/trans-isomerase, activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex"]
["YIR015W","RPR2",6322205,1,2,0,0,"Rpr2","3.1.26.5_Ribonuclease P","Eukaryota","Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits"]
["YIR023W","DAL81",6322214,1,28,0,0,"Zn_clus~Fungal_trans","NA","Dikarya","Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism"]
["YJL036W","SNX4",6322424,1,16,0,0,"PX","NA","Eukaryota","Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complexes with Snx41p and with Atg20p"]
["YJL042W","MHP1",6322419,1,4,0,0,"NA","NA","Ascomycota","Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins"]
["YJL052W","TDH1",6322409,1,14,0,0,"DapB_N~Gp_dh_N~Gp_dh_C","1.2.1.12_Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)","cellular organisms","Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall"]
["YJL065C","DLS1",6322397,1,11,0,0,"NA","NA","Fungi/Metazoa group","Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing"]
["YJL078C","PRY3",6322383,1,5,0,0,"SCP","NA","Saccharomyces cerevisiae","Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins"]
["YJL130C","URA2",6322331,1,40,0,0,"CPSase_sm_chain~GATase~Peptidase_C26~CPSase_L_chain~CPSase_L_D2~CPSase_L_D3~CPSase_L_chain~CPSase_L_D2~CPSase_L_D2~MGS~OTCace_N~OTCace","2.1.3.2_Aspartate carbamoyltransferase|6.3.5.5_Carbamoyl-phosphate synthase (glutamine-hydrolyzing)","cellular organisms","Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP"]
["YJL149W","DAS1",6322312,1,7,0,0,"F-box","NA","Saccharomycetaceae","Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil"]
["YJL156C","SSY5",6322305,1,4,0,0,"Peptidase_S64","NA","Ascomycota","Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes"]
["YJL180C","ATP12",6322281,1,9,0,0,"ATP12","NA","cellular organisms","Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency"]
["YJL183W","MNN11",6322278,1,25,0,0,"Glyco_transf_34","NA","Ascomycota","Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p"]
["YJL210W","PEX2",6322250,1,17,0,0,"Pex2_Pex12","NA","Eukaryota","RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import"]
["YJR001W","AVT1",6322460,1,4,0,0,"Aa_trans","NA","Eukaryota","Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"]
["YJR006W","POL31",6322465,1,4,0,0,"DNA_pol_E_B","NA","cellular organisms","DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair"]
["YJR010W","MET3",6322469,1,6,0,0,"ATP-sulfurylase","2.7.7.4_Sulfate adenylyltransferase","cellular organisms","ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism"]
["YJR011C","YJR011C",6322471,1,4,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YJR026W","YJR026W",6322486,1,4,0,0,"TYA","NA","Saccharomycetales","NA"]
["YJR039W","YJR039W",6322498,1,23,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YJR042W","NUP85",6322502,1,4,0,0,"Nucleopor_Nup85","NA","Ascomycota","Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking"]
["YJR094W-A","RPL43B",6322554,1,3,0,0,"Ribosomal_L37ae","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein"]
["YKL019W","RAM2",6322833,1,1,0,0,"PPTA~PPTA~PPTA~PPTA~PPTA","2.5.1.58_Protein farnesyltransferase|2.5.1.59_Protein geranylgeranyltransferase type I","Eukaryota","Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor"]
["YKL020C","SPT23",6322832,1,7,0,0,"TIG~Ank~Ank","NA","Dikarya","ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting"]
["YKL021C","MAK11",6322831,1,2,0,0,"WD40~WD40~WD40~WD40","NA","cellular organisms","Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats"]
["YKL037W","AIM26",6322814,1,36,1,0,"NA","NA","Saccharomyces cerevisiae","Putative protein of unknown function; null mutant is viable and displays increased frequency of mitochondrial genome loss (petite formation)"]
["YKL052C","ASK1",6322799,1,2,0,0,"DASH_Ask1","NA","Saccharomycetaceae","Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases"]
["YKL056C","TMA19",6322794,1,2,0,0,"TCTP","NA","Eukaryota","Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress"]
["YKL077W","YKL077W",6322773,1,25,1,0,"NA","NA","Saccharomycetales","NA"]
["YKL082C","RRP14",6322768,1,2,0,0,"SURF6","NA","Eukaryota","Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family"]
["YKL126W","YPK1",6322723,1,41,0,0,"Pkinase~Pkinase_Tyr~Pkinase_C","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK"]
["YKL139W","CTK1",6322710,1,16,0,0,"Pkinase~Pkinase_Tyr","2.7.11.23_[RNA-polymerase]-subunit kinase","cellular organisms","Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing"]
["YKL140W","TGL1",6322709,1,6,0,0,"Abhydro_lipase~Abhydrolase_1","3.1.1.13_Sterol esterase","cellular organisms","Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes"]
["YKL144C","RPC25",6322705,1,4,0,0,"RNA_pol_Rpb7_N~RNA_pol_Rbc25","NA","cellular organisms","RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p"]
["YKL152C","GPM1",6322697,1,3,0,0,"PGAM","5.4.2.1_Phosphoglycerate mutase","cellular organisms","Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis"]
["YKL173W","SNU114",6322675,1,2,0,0,"GTP_EFTU~GTP_EFTU_D2~EFG_IV~EFG_C","NA","cellular organisms","GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2"]
["YKL182W","FAS1",6322666,1,10,0,0,"DUF1729~MaoC_dehydratas~Acyl_transf_1","1.3.1.9_Enoyl-[acyl-carrier-protein] reductase (NADH)|2.3.1.38_[Acyl-carrier-protein] S-acetyltransferase|2.3.1.39_[Acyl-carrier-protein] S-malonyltransferase|2.3.1.86_Fatty-acyl-CoA synthase|3.1.2.14_Oleoyl-[acyl-carrier-protein] hydrolase|4.2.1.61_3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase","cellular organisms","Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities"]
["YKL190W","CNB1",6322658,1,31,0,0,"efhand~efhand~efhand~efhand","NA","cellular organisms","Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1"]
["YKL211C","TRP3",6322638,1,34,0,0,"GATase~IGPS","4.1.1.48_Indole-3-glycerol-phosphate synthase|4.1.3.27_Anthranilate synthase","cellular organisms","Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p"]
["YKR002W","PAP1",6322854,1,3,0,0,"PAP_central~NTP_transf_2~PAP_RNA-bind","2.7.7.19_Polynucleotide adenylyltransferase","cellular organisms","Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs"]
["YKR022C","NTR2",6322874,1,4,0,0,"NA","NA","Saccharomycetaceae","Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly"]
["YKR028W","SAP190",6322880,1,18,0,0,"SAPS","NA","Eukaryota","Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p"]
["YKR071C","DRE2",6322924,1,7,0,0,"DUF689","NA","Eukaryota","Protein of unknown function; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2"]
["YKR103W","NFT1",6322956,1,10,0,0,"ABC_membrane~ABC_membrane~ABC_tran~ABC_membrane","NA","cellular organisms","Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds."]
["YLL009C","COX17",6323020,1,38,0,0,"COX17~CHCH~Cmc1","NA","Eukaryota","Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase"]
["YLL019C","KNS1",6323009,1,15,0,0,"Pkinase~Pkinase","2.7.12.1_Dual-specificity kinase","cellular organisms","Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues"]
["YLL029W","RUP2",6322999,1,6,0,0,"NA","3.4.11.9_Xaa-Pro aminopeptidase","cellular organisms","Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation"]
["YLR078C","BOS1",6323107,1,2,0,0,"V-SNARE","NA","Eukaryota","v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi"]
["YLR134W","PDC5",6323163,1,6,0,0,"TPP_enzyme_N~TPP_enzyme_M~TPP_enzyme_C","4.1.1.1_Pyruvate decarboxylase","cellular organisms","Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism"]
["YLR164W","YLR164W",6323193,1,11,0,0,"CybS","NA","Fungi/Metazoa group","NA"]
["YLR196W","PWP1",6323225,1,4,0,0,"WD40","NA","cellular organisms","Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily"]
["YLR208W","SEC13",6323237,1,22,0,0,"WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles"]
["YLR211C","YLR211C",9755338,1,7,1,0,"bZIP_1","NA","Saccharomycetaceae","NA"]
["YLR212C","TUB4",6323241,1,8,0,0,"Tubulin~Tubulin_C","NA","cellular organisms","Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body"]
["YLR223C","IFH1",6323252,1,7,0,0,"CRF1","NA","Saccharomycetaceae","Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate"]
["YLR224W","YLR224W",6323253,1,9,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YLR267W","BOP2",6323297,1,8,1,0,"NA","NA","Saccharomycetaceae","Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation"]
["YLR268W","SEC22",6323298,1,33,0,0,"Synaptobrevin","NA","Eukaryota","R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog"]
["YLR272C","YCS4",6323302,1,6,0,0,"HEAT","NA","Eukaryota","Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus"]
["YLR276C","DBP9",6323306,1,2,0,0,"ResIII~DEAD~Helicase_C~Helicase_C","NA","cellular organisms","ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit"]
["YLR286C","CTS1",6323316,1,13,0,0,"Glyco_hydro_18~CBM_19","3.2.1.14_Chitinase","cellular organisms","Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p"]
["YLR310C","CDC25",6323341,1,6,0,0,"SH3_1~SH3_2~RasGEF_N~RasGEF","NA","Eukaryota","Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1"]
["YLR342W","FKS1",6323374,1,24,0,0,"Glucan_synthase","2.4.1.34_1,3-beta-glucan synthase","Eukaryota","Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling"]
["YLR343W","GAS2",6323375,1,7,0,0,"Glyco_hydro_72~X8","NA","Eukaryota","1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p"]
["YLR425W","TUS1",6323457,1,5,0,0,"PH~CNH","NA","Dikarya","Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate"]
["YLR430W","SEN1",6323462,1,4,0,0,"NA","NA","Eukaryota","Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis"]
["YLR438W","CAR2",6323470,1,3,0,0,"Aminotran_3","2.6.1.13_Ornithine aminotransferase","cellular organisms","L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive"]
["YLR456W","YLR456W",6323489,1,3,1,0,"Pyridox_oxidase","NA","cellular organisms","NA"]
["YML010W","SPT5",6323632,1,3,0,0,"Supt5~Supt5~KOW~KOW","NA","Eukaryota","Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing"]
["YML013W","UBX2",6323628,1,16,0,0,"UBX","NA","Eukaryota","Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain"]
["YML015C","TAF11",6323626,1,4,0,0,"TAFII28","NA","Fungi/Metazoa group","TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors"]
["YML028W","TSA1",6323613,1,28,0,0,"Redoxin~AhpC-TSA~1-cysPrx_C","1.11.1.15_Peroxiredoxin","cellular organisms","Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype"]
["YMR052W","FAR3",6323696,1,6,0,0,"NA","NA","Saccharomycetaceae","Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p"]
["YMR065W","KAR5",6323710,1,4,0,0,"Tht1","NA","Ascomycota","Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone"]
["YMR067C","UBX4",6323712,1,20,0,0,"UBX","NA","Eukaryota","UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p"]
["YMR068W","AVO2",6323713,1,2,0,0,"Ank~Ank~Ank","NA","cellular organisms","Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth"]
["YMR104C","YPK2",6323751,1,3,0,0,"Pkinase~Pkinase_Tyr~Pkinase_C","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK"]
["YMR132C","JLP2",6323780,1,5,1,0,"DUF814","NA","Eukaryota","Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)"]
["YMR133W","REC114",6323781,1,4,0,0,"Meiotic_rec114","NA","Saccharomycetaceae","Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division"]
["YMR170C","ALD2",6323822,1,7,0,0,"Aldedh","NA","cellular organisms","Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p"]
["YMR178W","YMR178W",6323832,1,2,1,0,"MoCF_biosynth","NA","cellular organisms","NA"]
["YMR180C","CTL1",6323834,1,2,0,0,"mRNA_triPase","3.1.3.33_Polynucleotide 5'-phosphatase","Dikarya","RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm"]
["YMR216C","SKY1",6323872,1,9,0,0,"Pkinase~Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1"]
["YMR218C","TRS130",6323874,1,5,0,0,"NA","NA","Fungi/Metazoa group","One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1"]
["YMR233W","TRI1",6323889,1,6,0,0,"DEK_C~SWIB","NA","cellular organisms","Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus"]
["YMR239C","RNT1",6323895,1,2,0,0,"Ribonuclease_3~dsrm","3.1.26.3_Ribonuclease III","cellular organisms","RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end"]
["YMR244C-A","YMR244C-A",6323902,1,3,1,0,"NA","NA","Eukaryota","NA"]
["YMR272C","SCS7",6323928,1,16,0,0,"Cyt-b5~FA_hydroxylase","NA","cellular organisms","Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth"]
["YMR284W","YKU70",6323940,1,11,0,0,"Ku_N~Ku~Ku_C","NA","Eukaryota","Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair"]
["YMR288W","HSH155",6323944,1,5,0,0,"NA","NA","Eukaryota","U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155"]
["YMR314W","PRE5",6323974,1,2,0,0,"Proteasome_A_N~Proteasome","3.4.25.1_Proteasome endopeptidase complex","cellular organisms","Alpha 6 subunit of the 20S proteasome"]
["YMR315W","YMR315W",6323975,1,10,1,0,"GFO_IDH_MocA~GFO_IDH_MocA_C","NA","cellular organisms","NA"]
["YNL009W","IDP3",6324319,1,4,0,0,"Iso_dh~Iso_dh","1.1.1.42_Isocitrate dehydrogenase (NADP(+))","cellular organisms","Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids"]
["YNL016W","PUB1",6324312,1,7,0,0,"RRM_1~RRM_1~RRM_1","NA","cellular organisms","Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes"]
["YNL020C","ARK1",6324308,1,6,0,0,"Pkinase~Pkinase","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis"]
["YNL030W","HHF2",6324298,1,12,0,0,"Histone~CBFD_NFYB_HMF~TAF","NA","Eukaryota","One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity"]
["YNL035C","YNL035C",6324293,1,3,1,0,"WD40~WD40","NA","Eukaryota","NA"]
["YNL074C","MLF3",6324255,1,4,0,0,"NA","NA","Saccharomycetaceae","Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide"]
["YNL084C","END3",6324245,1,18,0,0,"NA","NA","Fungi/Metazoa group","EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p"]
["YNL094W","APP1",6324235,1,9,0,0,"DUF2183","NA","cellular organisms","Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization"]
["YNL113W","RPC19",6324215,1,4,0,0,"RNA_pol_L","NA","cellular organisms","RNA polymerase subunit, common to RNA polymerases I and III"]
["YNL131W","TOM22",6324198,1,6,0,0,"Tom22","NA","Dikarya","Component of the TOM (translocase of outer membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between the TOM and TIM complexes"]
["YNL136W","EAF7",6324193,1,11,0,0,"CT20","NA","Ascomycota","Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A"]
["YNL178W","RPS3",6324151,1,4,0,0,"KH_2~Ribosomal_S3_C","NA","cellular organisms","Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins"]
["YNL183C","NPR1",6324146,1,30,0,0,"Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation"]
["YNL189W","SRP1",6324140,1,5,0,0,"IBB~Arm~Arm~Arm~Arm~Arm~Arm~Arm~Arm","NA","Eukaryota","Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation"]
["YNL197C","WHI3",6324132,1,43,0,0,"RRM_1","NA","Saccharomycetaceae","RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start"]
["YNL218W","MGS1",6324111,1,5,0,0,"RuvB_N~AAA~AAA_5","NA","cellular organisms","Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)"]
["YNL221C","POP1",6324108,1,30,0,0,"POP1~POP1~POPLD","3.1.26.5_Ribonuclease P","Eukaryota","Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P"]
["YNL232W","CSL4",6324097,1,2,0,0,"EXOSC1","NA","Eukaryota","Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation"]
["YNL238W","KEX2",6324091,1,12,0,0,"Peptidase_S8~P_proprotein","3.4.21.61_Kexin","cellular organisms","Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway"]
["YNL243W","SLA2",6324086,1,5,0,0,"ANTH~ENTH~I_LWEQ","NA","Eukaryota","Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo"]
["YNL258C","DSL1",6324071,1,2,0,0,"NA","NA","Saccharomycetaceae","Peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interacts with coatomer, the major component of the COPI vesicle protein coat; also interacts with Cin5p and Sec39p"]
["YNL270C","ALP1",6324059,1,7,0,0,"AA_permease~DUF2081","NA","cellular organisms","Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression"]
["YNL297C","MON2",6324033,1,22,0,0,"NA","NA","Eukaryota","Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins"]
["YNL323W","LEM3",6324006,1,45,0,0,"CDC50","NA","Eukaryota","Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane"]
["YNR009W","NRM1",6324336,1,5,0,0,"Whi5","NA","Saccharomycetaceae","Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase"]
["YNR016C","ACC1",6324343,1,11,0,0,"CPSase_L_chain~CPSase_L_D2~Biotin_carb_C~Biotin_lipoyl~ACC_central~Carboxyl_trans","6.3.4.14_Biotin carboxylase|6.4.1.2_Acetyl-CoA carboxylase","cellular organisms","Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids"]
["YNR032C-A","HUB1",6324360,1,5,0,0,"ubiquitin","NA","Eukaryota","Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear"]
["YNR071C","YNR071C",6324399,1,2,1,0,"Aldose_epim","NA","cellular organisms","NA"]
["YOL008W","COQ10",6324566,1,9,0,0,"Polyketide_cyc2~Polyketide_cyc","NA","cellular organisms","Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes"]
["YOL012C","HTZ1",6324562,1,28,0,0,"Histone","NA","Eukaryota","Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin"]
["YOL018C","TLG2",6324555,1,30,0,0,"Syntaxin~SNARE","NA","Eukaryota","Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation"]
["YOL032W","OPI10",6324541,1,8,0,0,"DUF775","NA","Fungi/Metazoa group","Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline"]
["YOL036W","YOL036W",6324536,1,10,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOL039W","RPP2A",6324534,1,15,0,0,"Ribosomal_60s","NA","cellular organisms","Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm"]
["YOL041C","NOP12",6324532,1,4,0,0,"RRM_1","NA","Eukaryota","Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe"]
["YOL056W","GPM3",6324516,1,17,0,0,"PGAM","5.4.2.1_Phosphoglycerate mutase","cellular organisms","Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event"]
["YOL083W","YOL083W",6324489,1,9,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YOL087C","YOL087C",6324485,1,29,1,0,"WD40","NA","Eukaryota","NA"]
["YOL113W","SKM1",6324459,1,6,0,0,"PH~PBD~Pkinase~Pkinase_Tyr","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth"]
["YOL125W","TRM13",6324447,1,3,0,0,"TRM13","NA","Eukaryota","2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases"]
["YOL139C","CDC33",6324433,1,2,0,0,"IF4E","NA","Eukaryota","Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)"]
["YOR002W","ALG6",6324575,1,30,0,0,"Alg6_Alg8","NA","Eukaryota","Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease"]
["YOR008C-A","YOR008C-A",6324582,1,26,1,0,"NA","NA","Saccharomyces cerevisiae","NA"]
["YOR016C","ERP4",6324590,1,20,0,0,"EMP24_GP25L","NA","Eukaryota","Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"]
["YOR031W","CRS5",6324605,1,4,0,0,"NA","NA","Saccharomyces cerevisiae","Copper-binding metallothionein, required for wild-type copper resistance"]
["YOR054C","VHS3",6324629,1,9,0,0,"Flavoprotein","NA","Saccharomycetales","Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis"]
["YOR066W","MSA1",6324640,1,9,0,0,"NA","NA","Saccharomycetaceae","Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate"]
["YOR100C","CRC1",6324674,1,5,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation"]
["YOR113W","AZF1",6324687,1,7,0,0,"zf-C2H2~zf-C2H2~zf-C2H2~zf-C2H2","NA","Eukaryota","Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance"]
["YOR119C","RIO1",6324693,1,2,0,0,"RIO1","2.7.11.1_Non-specific serine/threonine protein kinase","cellular organisms","Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA"]
["YOR122C","PFY1",6324696,1,2,0,0,"Profilin","NA","cellular organisms","Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol"]
["YOR144C","ELG1",6324718,1,13,0,0,"NA","NA","Fungi/Metazoa group","Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair"]
["YOR161C","PNS1",6324735,1,8,0,0,"DUF580","NA","Eukaryota","Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport"]
["YOR183W","FYV12",6324757,1,2,1,0,"NA","NA","Saccharomyces cerevisiae","Protein of unknown function, required for survival upon exposure to K1 killer toxin"]
["YOR192C","THI72",6324766,1,9,0,0,"Transp_cyt_pur","NA","cellular organisms","Transporter of thiamine or related compound; shares sequence similarity with Thi7p"]
["YOR206W","NOC2",6324780,1,4,0,0,"Noc2","NA","Eukaryota","Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors"]
["YOR207C","RET1",6324781,1,11,0,0,"RNA_pol_Rpb2_1~RNA_pol_Rpb2_2~RNA_pol_Rpb2_3~RNA_pol_Rpb2_4~RNA_pol_Rpb2_5~RNA_pol_Rpb2_6~RNA_pol_Rpb2_7","2.7.7.6_DNA-directed RNA polymerase","cellular organisms","Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs"]
["YOR214C","YOR214C",6324788,1,3,1,0,"NA","NA","Saccharomycetaceae","NA"]
["YOR232W","MGE1",6324806,1,9,0,0,"GrpE","NA","cellular organisms","Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE"]
["YOR258W","HNT3",6324832,1,6,0,0,"HIT","NA","Eukaryota","Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia"]
["YOR289W","YOR289W",6324863,1,5,1,0,"AMMECR1","NA","cellular organisms","NA"]
["YOR322C","LDB19",6324898,1,17,0,0,"Arrestin_N","NA","Ascomycota","Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface"]
["YOR327C","SNC2",6324903,1,25,0,0,"Synaptobrevin","NA","Eukaryota","Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins"]
["YOR338W","YOR338W",6324914,1,8,1,0,"SWIRM","NA","Ascomycota","NA"]
["YOR355W","GDS1",6324931,1,10,0,0,"NA","NA","Saccharomycetales","Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YOR359W","VTS1",6324935,1,11,0,0,"SAM_2","NA","Saccharomycetaceae","Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic"]
["YPL019C","VTC3",6325238,1,8,0,0,"SPX~VTC","NA","Eukaryota","Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion"]
["YPL021W","ECM23",6325236,1,8,0,0,"GATA","NA","Eukaryota","Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p"]
["YPL030W","TRM44",6325227,1,5,0,0,"AdoMet_MTase~AdoMet_MTase","NA","Eukaryota","tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene"]
["YPL057C","SUR1",6325200,1,32,0,0,"Gly_transf_sug","NA","cellular organisms","Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p"]
["YPL076W","GPI2",6325181,1,5,0,0,"GPI2","2.4.1.198_Phosphatidylinositol N-acetylglucosaminyltransferase","Eukaryota","Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein"]
["YPL079W","RPL21B",6325178,1,13,0,0,"Ribosomal_L21e","NA","cellular organisms","Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein"]
["YPL137C","GIP3",6325121,1,4,0,0,"NA","NA","Ascomycota","Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments"]
["YPL147W","PXA1",6325110,1,4,0,0,"ABC_membrane_2~ABC_tran","NA","cellular organisms","Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins"]
["YPL151C","PRP46",6325106,1,8,0,0,"WD40~WD40~WD40~WD40~WD40","NA","cellular organisms","Splicing factor that is found in the Cef1p subcomplex of the spliceosome"]
["YPL153C","RAD53",6325104,1,9,0,0,"FHA~Pkinase~Pkinase_Tyr~FHA","NA","cellular organisms","Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication"]
["YPL157W","TGS1",6325100,1,5,0,0,"Methyltransf_15","NA","cellular organisms","Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology"]
["YPL159C","PET20",6325098,1,11,0,0,"Pet20","NA","Saccharomycetaceae","Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome"]
["YPL169C","MEX67",6325088,1,6,0,0,"TAP_C","NA","Eukaryota","Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP"]
["YPL239W","YAR1",6325017,1,5,0,0,"Ank~Ank","NA","cellular organisms","Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock"]
["YPL260W","YPL260W",6324994,1,7,1,0,"DUF2408~DUF2408~DUF2408","NA","Dikarya","NA"]
["YPL266W","DIM1",6324989,1,3,0,0,"RrnaAD~Methyltransf_11~Methyltransf_12","NA","cellular organisms","Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing"]
["YPR021C","AGC1",6325278,1,11,0,0,"Mito_carr~Mito_carr~Mito_carr","NA","Eukaryota","Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis"]
["YPR049C","ATG11",6325306,1,8,0,0,"ATG11","NA","Ascomycota","Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the pro-autophagosomal structure (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS"]
["YPR060C","ARO7",6325317,1,29,0,0,"CM_2~Chlam_vir","5.4.99.5_Chorismate mutase","Eukaryota","Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis"]
["YPR127W","YPR127W",6325384,1,5,1,0,"Aldo_ket_red","1.1.1.65_Pyridoxine 4-dehydrogenase","cellular organisms","NA"]
["YPR137W","RRP9",6325394,1,3,0,0,"WD40~WD40","NA","cellular organisms","Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein"]
["YAL010C","MDM10",6319309,1,9,0,1,"NA","NA","Dikarya","Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins"]
["YBR001C","NTH2",6319473,1,3,0,1,"Trehalase_Ca-bi~Trehalase","3.2.1.28_Alpha,alpha-trehalase","cellular organisms","Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses"]
["YBR037C","SCO1",6319511,1,7,0,1,"SCO1-SenC","NA","cellular organisms","Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins"]
["YBR238C","YBR238C",6319715,1,7,0,1,"NA","NA","Saccharomycetales","NA"]
["YCL017C","NFS1",10383773,1,7,0,1,"Aminotran_5","2.8.1.7_Cysteine desulfurase","cellular organisms","Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria"]
["YDL045W-A","MRP10",6320158,1,4,0,1,"CHCH","NA","Ascomycota","Mitochondrial ribosomal protein of the small subunit"]
["YDL107W","MSS2",6320096,1,5,0,1,"NA","NA","Saccharomycetales","Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p"]
["YDR125C","ECM18",6320330,1,5,0,1,"Abhydrolase_1","NA","Eukaryota","Protein of unknown function, similar to Rlp24p"]
["YDR375C","BCS1",6320583,1,5,0,1,"BCS1_N~AAA~VirE~ATP_bind_1","NA","cellular organisms","Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family"]
["YER078C","ICP55",6320922,1,8,1,1,"AMP_N~Peptidase_M24","NA","cellular organisms","Putative mitochondrial metallopeptidase"]
["YER153C","PET122",6321001,1,4,0,1,"PET122","NA","Saccharomycetaceae","Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane"]
["YGL219C","MDM34",6321220,1,3,0,1,"NA","NA","Dikarya","Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32"]
["YGR243W","FMP43",6321682,1,5,1,1,"UPF0041","NA","Eukaryota","Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YHR083W","SAM35",6321875,1,2,0,1,"NA","NA","Saccharomycetales","Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane"]
["YIR024C","YIR024C",6322215,1,13,0,1,"NA","NA","Saccharomycetaceae","NA"]
["YJL066C","MPM1",6322395,1,11,0,1,"NA","NA","Saccharomycetales","Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches"]
["YJL104W","PAM16",6322357,1,3,0,1,"Pam16","NA","Eukaryota","Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain"]
["YJL112W","MDV1",6322349,1,8,0,1,"WD40~WD40~WD40~WD40","NA","cellular organisms","Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats"]
["YKL011C","CCE1",6322841,1,6,0,1,"Ydc2-catalyt","NA","Ascomycota","Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA"]
["YKL085W","MDH1",6322765,1,6,0,1,"Ldh_1_N~Ldh_1_C","1.1.1.37_Malate dehydrogenase","cellular organisms","Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated"]
["YKL195W","MIA40",37362671,1,16,0,1,"CHCH","NA","Dikarya","Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins"]
["YLR105C","SEN2",6323134,1,3,0,1,"tRNA_int_endo","3.1.27.9_tRNA-intron endonuclease","cellular organisms","Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease"]
["YML025C","YML6",6323616,1,3,0,1,"NA","NA","cellular organisms","Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins"]
["YMR256C","COX7",6323912,1,5,0,1,"NA","1.9.3.1_Cytochrome-c oxidase","Saccharomycetales","Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"]
["YNL055C","POR1",6324273,1,4,0,1,"Porin_3","NA","Eukaryota","Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated"]
["YOR045W","TOM6",6324619,1,22,0,1,"NA","NA","Saccharomycetales","Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex"]
["YOR286W","AIM42",6324860,1,13,1,1,"Rhodanese","NA","cellular organisms","Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media"]
["YPL072W","UBP16",6325184,1,10,0,1,"UCH","NA","Eukaryota","Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria"]
["YPR004C","AIM45",6325261,1,2,0,1,"ETF~ETF_alpha","NA","cellular organisms","Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with yeast frataxin Yfh1p; null mutant displays increased frequency of mitochondrial genome loss (petite formation)"]
["YPR024W","YME1",6325281,1,12,0,1,"IstB~AAA~AAA_3~AAA_5~Mg_chelatase~Sigma54_activat~Peptidase_M41","NA","cellular organisms","Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover"]
["YPR134W","MSS18",6325392,1,5,0,1,"NA","NA","Saccharomycetaceae","Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions"]

{"sheet":"Some unch. SCP-hubs","index":1,"n_rows":70,"n_cols":4,"rows_kept":70,"cut":false,"hidden":false,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["Claases: CW: cell wall; ME: metabolic enzyme; MI: mitochondrial; RN: RNA metabolism/translation; TF: transcription factor; TM: transmembrane"]
["ORF","GI","Class","Manual annotation based on sequence analysis and literature searches (for only a subset of the genes)"]
["YBR071W",6319545,"CW","Yeast specific low complexity protein; induced by cell wall stress."]
["YFL051C",14318468,"CW","Flocculation lectin"]
["YJR061W",6322521,"CW ME","ME Mnn4;mannan kinase; relative of bacterial LicD; cell wall"]
["YBR204C",6319681,"ME","alpha/beta hydrolase"]
["YDL057W",6320146,"ME","alpha/beta hydrolase"]
["YDR307W",6320513,"ME","MIR domains;protein mannosyltransferase family; membrane protein; could be cell-wall"]
["YER152C",6321000,"ME","PLP-dependent aminotransferase"]
["YER163C",6321011,"ME","A distinct superfamily of the Gamma-glutamyl cyclotransferase fold"]
["YGR111W",6321549,"ME","Fungus specific Acetyltransferase"]
["YHR009C",6321797,"ME","Rossmann fold oxidoreductase"]
["YIL108W",6322083,"ME","fungus specific metallopeptidase fused to a ricin-like beta-trefoil domain"]
["YIL165C",6322026,"ME","Yeast-specific nitrilase (C-N hydrolase) transfered from bacteria"]
["YJR149W",6322609,"ME","NPD family dioxygenase"]
["YKR043C",6322896,"ME","phosphoglycerate mutase type phosphatase"]
["YKR070W",6322923,"ME","HAD superfamily hydrolase"]
["YLR446W",6323479,"ME","Hexokinase"]
["YML082W",6323557,"ME","carbon-sulfur lyase like Cystathionine gamma-synthase"]
["YMR085W",6323731,"ME","SIS domain aminotransferase"]
["YOR012W",6324586,"ME","Fungus specific Acetyltransferase"]
["YOR059C",6324633,"ME","lipase"]
["YOR093C",6324667,"ME","acyl-CoA synthetase polyketide synthase-like"]
["YGR127W",6321566,"ME","NTN-hydrolase with conserved C; Highly conserved eukaryotic and bacterial family; induced in stress response"]
["YGR035C",6321472,"MI","small cerevisiae specific protein; paralog of another cerevisiae protein localizaed to the mitochondrion"]
["YDR115W",6320319,"MI RN","N MItochondrial ribosomal L34"]
["YGR102C",6321539,"MI RN","N Mitochondrial glu-tRNAGln amidotransferase subunit, GATC"]
["YGR250C",6321689,"RN","triple RRM RNA binding protein"]
["YLR132C",6323161,"RN","2H phosphoesterase"]
["YMR310C",6323970,"RN","SPOUT-fold RNA methylase"]
["YNL022C",6324306,"RN","SUN family RNA cytosine-C5-methylase"]
["YER130C",6320977,"TF","2*C2H2 Transcription factor; ortholog of stress response element binding protein Trichoderma atroviride  "]
["YER184C",6321032,"TF","C6 transcription factor (paralog of PDR1)"]
["YLR455W",6323488,"TF","BMB domain (chromatin protein)"]
["YAL018C",6319301,"TM","Fungus specific membrane protein"]
["YAR028W",6319332,"TM","M ECM34-like membrane protein (nuclear membrane?)"]
["YCR043C",6319891,"TM","yeast specific membrane protein"]
["YDL012C",6320192,"TM","CYSTM protein"]
["YDL133W",6320069,"TM","M Fungus specific membrane protein; Well-conserved membrane spanning region, poorly conserved N-terminus"]
["YDR210W",6320415,"TM","M low complexity protein with probable C-terminal membrane spanning segment."]
["YGR026W",6321463,"TM","fungus specific 4-TM protein"]
["YIL092W",6322099,"TM","yeast-specific membrane protein"]
["YJR015W",6322475,"TM","M Fungus specific membrane protein; Protein involved in nitrosoguanidine resistance"]
["YKR105C",6322958,"TM","MFS transporter"]
["YNR040W",6324368,"TM","yeast-specific membrane protein"]
["YOL092W",6324480,"TM","PQ loop superfamily membrane protein"]
["YIL001W",6322190,"Ub","Ank-POZ domain protein                        "]
["YDL063C",6320141,null,"Arm repeat protein"]
["YDR065W",6320270,null,"yeast specific protein involved in vacuolar acidification"]
["YEL025C",6320810,null,"yeast specific large protein "]
["YER034W",6320872,null,"yeast specific family with N-terminal positively charged helix"]
["YER128W",6320975,null,"Fungus-specific zinc finger protein (Cx2C,,,Cx2H)"]
["YER158C",6321006,null,"yeast specific low complexity protein with relatively conserved C-terminus"]
["YER187W",6321035,null,"yeast(and Sclerotinia) specific protein with a relationship to the yeast killer toxin KHS1 and dsRNA plasmid encoded toxin K2 and paralog YGL262W;induced in "]
["YGR130C",6321569,null,"yeast specific low complexity protein"]
["YIL055C",6322134,null,"Yeast-specific protein"]
["YIL161W",6322030,null,"Yeast-specific protein"]
["YJL043W",6322418,null,"Saccharomyces Vanderwaltozyma specific protein"]
["YJR003C",99030925,null,"Yeast specific protein with absolutely conserved NPGR motif "]
["YKR075C",6322928,null,"Yeast-specific Hex2 family"]
["YLR012C",37362676,null,"Saccharomyces/Ashbya specific protein"]
["YLR125W",6323154,null,"S.cerevisiae specific protein"]
["YML002W",6323641,null,"VSP9+ANKYRIN repeat protein; induced by heat and calcium shortage"]
["YMR018W",6323660,null,"peroxin5"]
["YMR031C",6323674,null,"yeast specific protein with low complexity; N-terminal globular domain"]
["YMR144W",6323793,null,"fibrous yeast specific nuclear protein"]
["YNL086W",6324243,null,"yeast-specific protein with HPXE motif"]
["YNL193W",6324136,null,"Fungus-specific low complexity protein"]
["YOL131W",6324441,null,"yeast-specific protein with conserved helix"]
["YOR385W",6324961,null,"Major yeast specific family including Dia1 and 3 other paralogs"]