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["Supplementary Data 1: Genes identified by phenomics whose deletion significantly decreased proficiency in culture after three cycles of desiccation (listed in order of increasing effect).  Genes encoding transcriptional regulators are highlighted in yellow, and protein kinases in green."]
["Systematic ID","Gene name","Fold-change","Description"]
["YNL089C","",-2.439026,"Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins"]
["YKL121W","DGR2",-2.484354,"Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds  "]
["YOR358W","HAP5",-2.552837,"Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex"]
["YKR042W","UTH1",-2.561371,"Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death"]
["YDR250C","",-2.676119,"Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"]
["YBR027C","",-2.773508,"Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data"]
["YPL056C","",-2.791866,"Putative protein of unknown function; deletion mutant is fluconazole resistant"]
["YLR169W","",-2.798315,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YER164W","CHD1",-2.845128,"Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes"]
["YCR033W","SNT1",-2.879564,"Subunit of the Set3C deacetylase complex; putative DNA-binding protein"]
["YMR037C","MSN2",-2.893052,"Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"]
["YLR292C","SEC72",-2.899856,"Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"]
["YKR035W-A","DID2",-2.935113,"Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors"]
["YCR062W",{"$error":"#N/A"},-2.939817,"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YOR286W","",-2.941305,"The authentic, non-tagged protein was localized to the mitochondria"]
["YHR049W","FSH1",-2.968162,"Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p"]
["YBR098W","MMS4",-3.047534,"Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair"]
["YKR028W","SAP190",-3.051463,"Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p"]
["YOR277C","",-3.079629,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20"]
["YNL198C","",-3.084276,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"]
["YDR443C","SSN2",-3.094396,"Protein required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; subunit of the RNA polymerase II mediator complex; essential for transcriptional regulation"]
["YLR202C","",-3.111268,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron"]
["YGR192C","TDH3",-3.123633,"Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall"]
["YHR195W","NVJ1",-3.148733,"Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)"]
["YDR121W","DPB4",-3.155948,"Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing"]
["YLR119W","SRN2",-3.191044,"Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus"]
["YNL123W","NMA111",-3.211566,"Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases"]
["YJL052W","TDH1",-3.237553,"Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall"]
["YPR046W","MCM16",-3.238337,"Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA"]
["YOR191W","RIS1",-3.263412,"Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain"]
["YER092W","IES5",-3.294155,"Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions"]
["YOL093W","TRM10",-3.312175,"tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs"]
["YKL085W","MDH1",-3.327362,"Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle"]
["YPL003W","ULA1",-3.341681,"Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation"]
["YNL206C","RTT106",-3.398883,"Protein with a role in regulation of Ty1 transposition"]
["YGR077C","PEX8",-3.497919,"Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p"]
["YML113W","DAT1",-3.52867,"DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability"]
["YCL001W","RER1",-3.529271,"Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER"]
["YGL031C","RPL24A",-3.529934,"Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"]
["YDR540C","",-3.583637,"Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci"]
["YNL219C","ALG9",-3.587324,"Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation"]
["YNL229C","URE2",-3.619183,"Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion"]
["YDR004W","RAD57",-3.712117,"Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p"]
["YHR133C","NSG1",-3.724888,"Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins"]
["YAL054C","ACS1",-3.725742,"Acetyl-coA synthetase isoform, expressed during growth on nonfermentable carbon sources and under aerobic conditions"]
["YOR124C","UBP2",-3.748813,"Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity"]
["YOR297C","TIM18",-3.755109,"Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex"]
["YOR355W","GDS1",-3.769613,"Protein of unknown function, required for growth on glycerol as a carbon source"]
["YBL082C","ALG3",-3.813953,"Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins"]
["YNL051W","COG5",-3.845399,"Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YLR384C","IKI3",-3.848779,"Subunit of RNA polymerase II elongator histone acetyltransferase complex, involved in maintaining its structural integrity; negatively regulates exocytosis independent of transcription, homolog of human familial dysautonomia (FD) protein"]
["YEL037C","RAD23",-3.855103,"Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins"]
["YOL088C","MPD2",-3.889023,"Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p"]
["YJL192C","SOP4",-3.895927,"ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER"]
["YKL062W","MSN4",-3.908825,"Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"]
["YBR290W","BSD2",-3.935348,"Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification"]
["YBL094C","",-3.96307,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W"]
["YNL079C","TPM1",-3.977037,"Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently"]
["YDR334W","SWR1",-3.992472,"Swi2/Snf2-related ATPase, component of the SWR1 complex; required for the incorporation of Htz1p into chromatin"]
["YBR131W","CCZ1",-3.996073,"Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway"]
["YDR108W","GSG1",-4.003636,"Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication"]
["YOR086C","TCB1",-4.00606,"Contains three calcium and lipid binding domains; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; C-terminal portion of Tcb1p, Tcb2p and Tcb3p interact"]
["YDR249C","",-4.012343,"Putative protein of unknown function"]
["YJR140C","HIR3",-4.061954,"Transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly"]
["YPR130C","",-4.070351,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YLR006C","SSK1",-4.097476,"Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate"]
["YDR022C","CIS1",-4.104593,"Protein of unknown function that may be involved in microtubule organization; high-copy suppressor of CIK1 deletion"]
["YDR069C","DOA4",-4.137931,"Ubiquitin hydrolase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole"]
["YDR369C","XRS2",-4.204651,"Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling"]
["YDL149W","ATG9",-4.276177,"Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes"]
["YBR031W","RPL4A",-4.302816,"N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins"]
["YOR089C","VPS21",-4.302852,"GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog"]
["YHR081W","LRP1",-4.358938,"Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination"]
["YLR417W","VPS36",-4.387194,"Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome"]
["YPL270W","MDL2",-4.412655,"Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane"]
["YDR448W","ADA2",-4.413013,"Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes"]
["YLR412W","",-4.454372,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR412W is not an essential gene"]
["YPL120W","VPS30",-4.495759,"Protein that forms a membrane-associated complex with Apg14p that is essential for autophagy; involved in a retrieval step of the carboxypeptidase Y receptor, Vps10p, to the late Golgi from the endosome; involved in vacuolar protein sorting"]
["YKL056C","TMA19",-4.503756,"Protein of unknown function that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YKL056C is not an essential gene"]
["YIL006W","YIA6",-4.524636,"Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs"]
["YBR058C","UBP14",-4.574042,"Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T"]
["YPR119W","CLB2",-4.574271,"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"]
["YDR194C","MSS116",-4.59765,"DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; presumed RNA helicase due to DEAD-box motif"]
["YOL111C","MDY2",-4.602424,"Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain"]
["YFL049W","SWP82",-4.621553,"Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p"]
["YJL159W","HSP150",-4.643475,"O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation"]
["YIL133C","RPL16A",-4.655349,"N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p"]
["YPL214C","THI6",-4.683899,"Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YHR034C","PIH1",-4.687023,"Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)"]
["YPL078C","ATP4",-4.697831,"Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YDR101C","ARX1",-4.720859,"Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex"]
["YPR106W","ISR1",-4.721978,"Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"]
["YJR095W","SFC1",-4.778233,"Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization"]
["YJR121W","ATP2",-4.798333,"Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YHR012W","VPS29",-4.818182,"Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval"]
["YJR048W","CYC1",-4.856641,"Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"]
["YOL004W","SIN3",-4.871642,"DNA binding subunit of Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression of meiosis-specific genes during vegetative growth and silencing; involved in telomere maintenance"]
["YFL015C","",-4.886207,"Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene"]
["YHR067W","HTD2",-4.887931,"Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology"]
["YMR230W","RPS10B",-4.893605,"Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10"]
["YDR350C","TCM10",-4.912065,"Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YDR125C","ECM18",-4.948914,"Protein of unknown function, similar to Rlp24p"]
["YLR425W","TUS1",-4.955786,"Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate"]
["YHR021C","RPS27B",-4.971846,"Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein"]
["YER151C","UBP3",-4.978997,"Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin"]
["YDR463W","STP1",-5.042745,"Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing"]
["YNL197C","WHI3",-5.043828,"RNA binding protein that binds to and sequesters the G1 cyclin CLN3 mRNA; regulates cell fate and dose-dependently inhibits passage through Start by regulating the critical cell size requirement necessary for cell cycle progression"]
["YNL003C","PET8",-5.106952,"S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth"]
["YLR085C","ARP6",-5.11415,"Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"]
["YNL090W","RHO2",-5.116182,"Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly"]
["YBR214W","SDS24",-5.145932,"One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis"]
["YGL147C","RPL9A",-5.155659,"Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins"]
["YBL042C","FUI1",-5.170491,"High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport"]
["YOL006C","TOP1",-5.175328,"Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination"]
["YLR059C","REX2",-5.175607,"RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases"]
["YOR371C","GPB1",-5.201081,"Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p, has signaling role in response to nutrients; involved in regulation of pseudohyphal growth through cAMP levels; homolog of Gpb2p"]
["YDR083W","RRP8",-5.214833,"Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation"]
["YKR092C","SRP40",-5.215079,"Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140"]
["YBR048W","RPS11B",-5.220042,"Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins"]
["YDR435C","PPM1",-5.242651,"Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits"]
["YCR045C","",-5.244313,"Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores"]
["YPL154C","PEP4",-5.246332,"Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates"]
["YCR098C","GIT1",-5.25071,"Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability"]
["YMR287C","MSU1",-5.259211,"RNase, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs"]
["YOL064C","MET22",-5.277453,"Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway"]
["YBR215W","HPC2",-5.330989,"Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes"]
["YGR118W","RPS23A",-5.362963,"Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"]
["YCR067C","SED4",-5.371279,"Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p"]
["YKR099W","BAS1",-5.413828,"Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways"]
["YPL225W","",-5.415798,"Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm "]
["YPL159C","PET20",-5.435787,"Protein required for respiratory growth and stability of the mitochondrial genome"]
["YHR142W","CHS7",-5.464245,"Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER"]
["YER154W","OXA1",-5.476484,"Translocase of the mitochondrial inner membrane, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; null is respiratory deficient"]
["YPR049C","ATG11",-5.492234,"Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy)"]
["YMR223W","UBP8",-5.504676,"Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B"]
["YBR194W","",-5.556903,"Protein proposed to be associated with the nuclear pore complex"]
["YBL013W","FMT1",-5.587085,"Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate"]
["YPL269W","KAR9",-5.602021,"Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase"]
["YNL257C","SIP3",-5.624707,"Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate"]
["YJR043C","POL32",-5.648471,"Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p"]
["YOR039W","CKB2",-5.672598,"Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases"]
["YJL185C","",-5.743502,"Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene"]
["YDR484W","VPS52",-5.789133,"Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin"]
["YGL020C","GET1",-5.791118,"Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance"]
["YKL010C","UFD4",-5.818688,"Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins"]
["YPR166C","MRP2",-5.830479,"Mitochondrial ribosomal protein of the small subunit"]
["YBR278W","DPB3",-5.844556,"Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle"]
["YJL047C","RTT101",-5.861977,"Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p"]
["YGR106C","",-5.863981,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane"]
["YDR457W","TOM1",-5.881821,"E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators"]
["YMR242C","RPL20A",-5.911558,"Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein"]
["YER031C","YPT31",-5.916649,"GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi"]
["YLL018C-A","COX19",-5.92629,"Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase"]
["YGR081C","SLX9",-5.934066,"Protein of unknown function; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant"]
["YDR329C","PEX3",-5.936682,"Peroxisomal membrane protein (PMP) required to recruit Pex19p chaperone to peroxisomes; plays selective, essential, direct role in PMP import as a docking factor for Pex19p"]
["YPL161C","BEM4",-5.965676,"Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length"]
["YHL044W","",-5.981658,"Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern"]
["YOL008W","COQ10",-6.010915,"Coenzyme Q binding protein, required for function of coenzyme Q in respiration by functioning in the delivery of Q<sub>6</sub> to its proper location for electron transport, START domain protein with homologs in bacteria and eukaryotes"]
["YNL071W","LAT1",-6.030389,"Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA"]
["YNL119W","NCS2",-6.046245,"Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"]
["YPL253C","VIK1",-6.071019,"Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p"]
["YPL173W","MRPL40",-6.094118,"Mitochondrial ribosomal protein of the large subunit"]
["YJL198W","PHO90",-6.10855,"Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"]
["YDL023C","",-6.143319,"Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 80% of ORF overlaps the verified gene GPD1; deletion in cyr1 mutant results in loss of stress resistance"]
["YDR076W","RAD55",-6.163038,"Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p"]
["YPL047W","SGF11",-6.165927,"Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation"]
["YNL323W","LEM3",-6.169591,"Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane"]
["YDR255C","RMD5",-6.190236,"Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis"]
["YDR219C","",-6.223162,"Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology"]
["YOR123C","LEO1",-6.231615,"Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation"]
["YOR043W","WHI2",-6.231925,"Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression"]
["YBR288C","APM3",-6.253471,"Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway"]
["YOL050C","",-6.258759,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"]
["YML128C","MSC1",-6.278412,"Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc1 mutants are defective in directing meiotic recombination events to homologous chromatids"]
["YML072C","TCB3",-6.278862,"Contains three calcium and lipid binding domains; localized to the bud; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; mRNA is targeted to the bud via the mRNA transport system involving She2p; C-terminal portion of Tcb1p, Tcb2p and Tcb3p interact"]
["YMR257C","PET111",-6.344828,"Specific translational activator for the COX2 mRNA, located in the mitochondrial inner membrane"]
["YLR420W","URA4",-6.373623,"Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate"]
["YDR290W","",-6.42371,"Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 42% of ORF overlaps the verified gene RTT103; deletion causes hydroxyuracil sensitivity"]
["YCL005W","LDB16",-6.478366,"Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface"]
["YNL041C","COG6",-6.502473,"Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YJL178C","ATG27",-6.521062,"Type II membrane protein that binds phosphatidylinositol 3-phosphate, required for the cytoplasm-to-vacuole targeting (Cvt) pathway"]
["YOL001W","PHO80",-6.556638,"Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance"]
["YCR024C","SLM5",-6.567568,"Mitochondrial asparaginyl-tRNA synthetase"]
["YLL001W","DNM1",-6.593809,"Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis"]
["YOL041C","NOP12",-6.595402,"Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe"]
["YDR335W","MSN5",-6.620168,"Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP"]
["YOL116W","MSN1",-6.626645,"Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus"]
["YBL100C","",-6.649351,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1 "]
["YDL173W","PAR32",-6.697507,"Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene "]
["YKR084C","HBS1",-6.710166,"GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components"]
["YPL057C","SUR1",-6.750714,"Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p"]
["YHR191C","CTF8",-6.779221,"Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion"]
["YHL033C","RPL8A",-6.780303,"Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"]
["YDR525W","API2",-6.780921,"Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology"]
["YHR132C","ECM14",-6.812875,"Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly"]
["YLR304C","ACO1",-6.814815,"Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy"]
["YGR102C","",-6.83871,"Putative protein of unknown function; transposon insertion mutant is salt sensitive, and the systematic deletion mutant has growth defects; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion"]
["YMR064W","AEP1",-6.852194,"Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase"]
["YDR298C","ATP5",-6.87013,"Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein)"]
["YOR309C","",-6.87205,"Hypothetical protein /// Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA"]
["YDR375C","BCS1",-6.890625,"Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins; member of the CDC48/PAS1/SEC18 ATPase family"]
["YGR214W","RPS0A",-6.925249,"Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"]
["YLR431C","ATG23",-6.957107,"Peripheral membrane protein, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway"]
["YPR185W","ATG13",-6.983845,"Phosphorylated protein that interacts with Vac8p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy"]
["YPR129W","SCD6",-7.015059,"Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin"]
["YHR129C","ARP1",-7.028941,"Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin"]
["YLR192C","HCR1",-7.087591,"Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA"]
["YNL236W","SIN4",-7.092263,"Subunit of the Mediator complex; interacts with the RNA polymerase II holoenzyme to postively or negatively regulate transcription; dispensible for basal transcription"]
["YHR111W","UBA4",-7.148381,"Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response"]
["YML009C","MRPL39",-7.268456,"Mitochondrial ribosomal protein of the large subunit"]
["YDL130W","RPP1B",-7.269433,"Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component"]
["YOR085W","OST3",-7.26951,"Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins"]
["YCR087C-A","",-7.27566,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene"]
["YDR080W","VPS41",-7.377919,"Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport"]
["YEL031W","SPF1",-7.378587,"P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1"]
["YDL172C","",-7.417611,"Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"]
["YDR237W","MRPL7",-7.444315,"Mitochondrial ribosomal protein of the large subunit"]
["YDR537C","",-7.451759,"Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W"]
["YOL110W","SHR5",-7.512202,"Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage; palmitoylation is required for Ras2p localization to the plasma membrane"]
["YDR451C","YHP1",-7.520413,"One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval"]
["YIL067C","",-7.588693,"Uncharacterized protein of unknown function  ("]
["YDR389W","SAC7",-7.596504,"GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate"]
["YGR227W","DIE2",-7.616082,"Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER, functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1"]
["YDR096W","GIS1",-7.618736,"Transcriptional factor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1"]
["YFR048W","RMD8",-7.627805,"Cytosolic protein required for sporulation"]
["YNL177C","MRPL22",-7.727679,"Mitochondrial ribosomal protein of the large subunit"]
["YML071C","COG8",-7.760751,"Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"]
["YPL195W","APL5",-7.779206,"Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function"]
["YMR193C-A","",-7.824071,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YHR206W","SKN7",-7.840933,"Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation"]
["YFL006W",{"$error":"#N/A"},-7.865121,"Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200"]
["YOR201C","",-7.964815,"Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA"]
["YGR220C","MRPL9",-8.003309,"Mitochondrial ribosomal protein of the large subunit"]
["YLR402W","",-8.007124,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  "]
["YGL180W","ATG1",-8.076677,"Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway"]
["YDR500C","RPL37B",-8.111132,"Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein"]
["YAR015W","ADE1",-8.126761,"N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine"]
["YDR276C","PMP3",-8.134016,"Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential"]
["YLL045C","RPL8B",-8.14301,"Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"]
["YLR427W","MAG2",-8.168315,"DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA"]
["YJL062W","LAS21",-8.169492,"Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity"]
["YGL212W","VAM7",-8.185566,"Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking"]
["YOR182C","RPS30B",-8.185699,"Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein"]
["YER123W","YCK3",-8.186998,"Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p"]
["YCR017C","CWH43",-8.189557,"Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion"]
["YPL005W","AEP3",-8.26087,"Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex"]
["YMR214W","SCJ1",-8.319104,"One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins"]
["YMR280C","CAT8",-8.322276,"Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements"]
["YNR004W","",-8.381157,"Hypothetical protein"]
["YPR164W","MMS1",-8.439516,"Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition"]
["YMR083W","ADH3",-8.486987,"Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production"]
["YOR091W","",-8.506036,"Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p"]
["YNL315C","ATP11",-8.531964,"Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase"]
["YHR154W","RTT107",-8.539295,"Protein that interacts with Mms22p and is implicated in Mms22-dependent DNA repair during S phase, damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; has four BRCT domains; has a role in regulation of Ty1 transposition"]
["YLR087C","CSF1",-8.567954,"Protein required for fermentation at low temperature"]
["YDR395W","SXM1",-8.595307,"Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1"]
["YML073C","RPL6A",-8.673913,"N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA"]
["YHR207C","SET5",-8.71391,"Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus"]
["YER017C","AFG3",-8.715736,"Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"]
["YLR068W","FYV7",-8.733796,"Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts"]
["YNL242W","ATG2",-8.785873,"Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking"]
["YGL054C","ERV14",-8.79562,"Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon"]
["YBR217W","ATG12",-8.95678,"Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy"]
["YNL091W","NST1",-8.992554,"Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1"]
["YGL064C","MRH4",-9,"Mitochondrial RNA helicase, plays an essential role in mitochondrial function"]
["YOR066W","",-9.01877,"Protein of unknown function; potential Cdc28p substrate"]
["YNR001C","CIT1",-9.059594,"Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein"]
["YIL148W","RPL40A",-9.068376,"Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes"]
["YJL023C","PET130",-9.088672,"Protein required for respiratory growth"]
["YDR363W","ESC2",-9.109589,"Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins"]
["YKL138C","MRPL31",-9.216667,"Mitochondrial ribosomal protein of the large subunit"]
["YML012W","ERV25",-9.240564,"Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport"]
["YCL001W-A","",-9.262175,"Putative protein of unknown function; YCL001W-A is not an essential gene"]
["YFR040W","SAP155",-9.275328,"Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p"]
["YPL148C","PPT2",-9.30819,"Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation"]
["YBR231C","SWC5",-9.388153,"Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin"]
["YBL079W","NUP170",-9.480243,"Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p"]
["YJL217W","",-9.515313,"Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase"]
["YEL053C","MAK10",-9.55573,"Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible"]
["YER040W","GLN3",-9.576389,"Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source"]
["YHR100C","GEP4",-9.607323,"Protein of unknown function required for respiratory growth; detected in highly purified mitochondria in high-throughput studies; null mutation confers sensitivity to tunicamycin and DTT and decreased levels of phosphatidylethanol"]
["YAL019W","FUN30",-9.641438,"Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p"]
["YER093C-A","AIM11",-9.709287,"Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron"]
["YPR100W","MRPL51",-9.711452,"Mitochondrial ribosomal protein of the large subunit"]
["YCR086W","CSM1",-9.83831,"Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance"]
["YER153C","PET122",-9.839127,"Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane"]
["YPL084W","BRO1",-9.89555,"Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes"]
["YLR083C","EMP70",-9.925492,"Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions, predicted to be a transmembrane protein"]
["YJL121C","RPE1",-10.058268,"D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress"]
["YGR150C","",-10.142857,"Putative protein of unknown function; deletion mutant has growth defects on both non-fermentable carbon sources and rich medium; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; contains PPR motifs"]
["YMR159C","ATG16",-10.210846,"Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure; essential for autophagy"]
["YBR026C","ETR1",-10.296875,"2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis"]
["YCR087W","",-10.343612,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene"]
["YMR150C","IMP1",-10.35148,"Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"]
["YPR083W","MDM36",-10.417119,"Protein required for normal mitochondrial morphology and inheritance"]
["YKL149C","DBR1",-10.511321,"RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition"]
["YHR134W","WSS1",-10.533549,"Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks"]
["YKR074W","",-10.632979,"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm"]
["YPR050C","",-10.635237,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W"]
["YFL007W","BLM10",-10.698564,"Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200"]
["YDL001W","RMD1",-10.73126,"Cytoplasmic protein required for sporulation"]
["YGR255C","COQ6",-10.765343,"Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; located on the matrix side of the mitochondrial inner membrane"]
["YBL080C","PET112",-10.802377,"Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog"]
["YLR114C","",-10.813253,"Mutation is syntheticly lethal with apl2 vps1 double mutant"]
["YNL322C","KRE1",-10.892874,"Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor"]
["YNL237W","YTP1",-10.925265,"Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins"]
["YMR039C","SUB1",-10.937029,"Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations"]
["YBR179C","FZO1",-10.960139,"Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain"]
["YHR171W","ATG7",-10.991107,"Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation."]
["YPL055C","LGE1",-11.001684,"Protein of unknown function; null mutant forms abnormally large cells"]
["YBR298C","MAL31",-11.030738,"Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C"]
["YPL002C","SNF8",-11.056589,"Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression"]
["YDL202W","MRPL11",-11.118993,"Mitochondrial ribosomal protein of the large subunit"]
["YCR020C-A","MAK31",-11.141908,"Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family"]
["YIL154C","IMP2'",-11.243446,"Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat"]
["YAL058C-A",null,-11.256659,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"]
["YCR063W","BUD31",-11.27867,"Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"]
["YOR106W","VAM3",-11.279412,"Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins"]
["YLR021W","IRC25",-11.331533,"Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions"]
["YHR200W","RPN10",-11.343191,"Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein"]
["YCR094W","CDC50",-11.408618,"Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p"]
["YDR469W","SDC1",-11.477129,"Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30"]
["YFL013W-A","",-11.477387,"Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching"]
["YHR198C","",-11.489262,"The authentic, non-tagged protein was localized to the mitochondria"]
["YIR009W","MSL1",-11.511719,"U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members"]
["YGR171C","MSM1",-11.572438,"Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p"]
["YCR050C","",-11.578623,"Hypothetical protein"]
["YDR116C","MRPL1",-11.599638,"Mitochondrial ribosomal protein of the large subunit"]
["YNL121C","TOM70",-11.740662,"Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins"]
["YNR040W","",-11.7508,"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"]
["YJL080C","SCP160",-11.784574,"Essential RNA-binding G protein effector of mating response pathway, predominantly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins"]
["YOR322C","LDB19",-11.885567,"Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface"]
["YBL051C","PIN4",-11.941616,"Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage"]
["YLR111W","",-12.005194,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"]
["YCL008C","STP22",-12.056058,"Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype"]
["YGR076C","MRPL25",-12.102273,"Mitochondrial ribosomal protein of the large subunit"]
["YLR069C","MEF1",-12.1893,"Mitochondrial elongation factor involved in translational elongation"]
["YCR068W","ATG15",-12.606129,"Lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway"]
["YOL081W","IRA2",-12.618432,"GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin"]
["YER084W","",-12.62559,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"]
["YPR070W","MED1",-12.652812,"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation"]
["YDL048C","STP4",-12.675119,"Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p"]
["YLR168C","",-12.708256,"Putative protein of unknown function that may be involved in intramitochondrial sorting; has homology to a domain of human PREL1; the green fluorescent protein (GFP)-tagged protein localizes to mitochondria"]
["YER145C","FTR1",-12.79353,"High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron"]
["YOR141C","ARP8",-12.821295,"Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"]
["YPL100W","ATG21",-12.880507,"Phosphatidylinositol 3,5-bisphosphate-binding protein required for maturation of pro-aminopeptidase I, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization"]
["YNL135C","FPR1",-12.880792,"Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function"]
["YBR277C","",-12.923723,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W"]
["YJL012C","VTC4",-12.934946,"Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion"]
["YDR126W","SWF1",-12.987179,"Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion"]
["YBL022C","PIM1",-13.030691,"Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis; involved in degradation of misfolded proteins in mitochondria; required for bigenesis and maintenance of mitochondria"]
["YPL042C","SSN3",-13.089181,"Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression"]
["YNL148C","ALF1",-13.118826,"Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance"]
["YJL024C","APS3",-13.145209,"Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function"]
["YJR102C","VPS25",-13.149414,"Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome"]
["YDR439W","LRS4",-13.307847,"Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin"]
["YOL071W","EMI5",-13.330554,"Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation"]
["YCR079W","",-13.363588,"Putative phosphoprotein phosphatase; contains mitochondrial targeting sequence; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; YCR079W is not an essential gene"]
["YMR193W","MRPL24",-13.495905,"Mitochondrial ribosomal protein of the large subunit"]
["YMR158W-A",null,-13.519326,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C "]
["YDR455C","",-13.552239,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W"]
["YIL110W","",-13.573276,"Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect and enhanced resistance to the glucan synthase inhibitor caspofungin"]
["YDL101C","DUN1",-13.57764,"Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair"]
["YDL133W","",-13.580599,"Hypothetical protein"]
["YNL307C","MCK1",-13.654391,"Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family"]
["YLR269C","",-13.655091,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YLR386W","VAC14",-13.811935,"Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; activator of Fab1p"]
["YPL144W","POC4",-13.8361,"Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions"]
["YPL008W","CHL1",-13.863475,"Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p"]
["YJL120W","",-13.864796,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1"]
["YLR410W","VIP1",-13.865482,"Protein of unknown function probably involved in the function of the cortical actin cytoskeleton; putative ortholog of S. pombe asp1+"]
["YMR156C","TPP1",-13.951748,"DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily"]
["YIR021W","MRS1",-14.014094,"Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA"]
["YPL065W","VPS28",-14.07473,"Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole"]
["YKL002W","DID4",-14.186603,"Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis"]
["YLR203C","MSS51",-14.431007,"Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein"]
["YCR036W","RBK1",-14.464248,"Putative ribokinase"]
["YGR289C","MAL11",-14.5394,"Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters"]
["YNL097C","PHO23",-14.591124,"Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)"]
["YGR085C","RPL11B",-14.596491,"Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11"]
["YPL149W","ATG5",-14.717418,"Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation"]
["YDR462W","MRPL28",-15.029088,"Mitochondrial ribosomal protein of the large subunit"]
["YLR218C","",-15.046801,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source"]
["YML033W",{"$error":"#N/A"},-15.065058,"Protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery"]
["YLR025W","SNF7",-15.149746,"One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes"]
["YCR081W","SRB8",-15.310056,"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression"]
["YMR157C","",-15.315255,"The authentic, non-tagged protein was localized to the mitochondria"]
["YDR197W","CBS2",-15.554535,"Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"]
["YNL094W","APP1",-15.563599,"Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization"]
["YOR360C","PDE2",-15.601415,"High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon"]
["YPL139C","UME1",-15.669487,"Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p"]
["YDR266C","",-15.675241,"Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain"]
["YGR056W","RSC1",-15.956103,"One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; required for expression of mid-late sporulation-specific genes; contains two essential  bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook"]
["YFR010W","UBP6",-15.99956,"Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds"]
["YML014W","TRM9",-16.004671,"tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response"]
["YLR110C","CCW12",-16.063025,"Cell wall protein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor"]
["YML097C","VPS9",-16.261029,"A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin"]
["YML090W","",-16.419335,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source"]
["YGR063C","SPT4",-16.48532,"Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing"]
["YPR051W","MAK3",-16.525952,"Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus"]
["YDL032W","",-16.53833,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene"]
["YJL204C","RCY1",-16.984208,"F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth"]
["YBR291C","CTP1",-17.058306,"Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family"]
["YER139C","",-17.190596,"Hypothetical protein"]
["YMR216C","SKY1",-17.263021,"SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1"]
["YJL101C","GSH1",-17.328115,"Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury"]
["YML115C","VAN1",-17.385036,"Component of the mannan polymerase I; forms a complex with Mnn9p, which is involved in in mannan synthesis; mutants are vanadate-resistant"]
["YJL144W","",-17.403338,"Cytoplasmic hydrophilin of unknown function, proposed to be involved in the dessication response; expression induced by osmotic stress, starvation conditions and during stationary phase; YJL144W is a non-essential gene"]
["YNL184C","",-17.585909,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data "]
["YER019W","ISC1",-17.610256,"Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain"]
["YMR190C","SGS1",-17.71028,"Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes"]
["YBR283C","SSH1",-17.899844,"Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential"]
["YJR077C","MIR1",-17.963765,"Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2 under normal conditions"]
["YDR048C","",-18.120336,"Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YMR179W","SPT21",-18.294314,"Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance"]
["YOR150W","MRPL23",-18.522595,"Mitochondrial ribosomal protein of the large subunit"]
["YFR007W","YFH7",-18.751526,"Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases"]
["YLR131C","ACE2",-18.900802,"Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate"]
["YPR066W","UBA3",-19.026684,"Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YMR167W","MLH1",-19.098054,"Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancer"]
["YKL076C","PSY1",-19.111507,"Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C"]
["YJR073C","OPI3",-19.275681,"Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis"]
["YNR031C","SSK2",-19.374417,"MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress"]
["YNL107W","YAF9",-19.539611,"Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain"]
["YLR262C","YPT6",-19.562401,"GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6"]
["YDR363W-A","SEM1",-20.093664,"Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1"]
["YFR021W","ATG18",-20.10189,"Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure"]
["YMR072W","ABF2",-20.279412,"Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation"]
["YNR037C","RSM19",-20.295181,"Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein"]
["YJR070C","LIA1",-20.542262,"Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning"]
["YGR135W","PRE9",-20.568182,"20S proteasome beta-type subunit; the only nonessential 20S subunit"]
["YNL120C","",-20.670568,"Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene NCS2"]
["YOR158W","PET123",-20.72552,"Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator"]
["YNR020C","",-20.868577,"Hypothetical protein"]
["YCR061W","",-21.00241,"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"]
["YHL023C","RMD11",-21.038462,"Protein required for sporulation"]
["YLR055C","SPT8",-21.173705,"Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters"]
["YOR067C","ALG8",-21.296296,"Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p"]
["YDR393W","SHE9",-21.650519,"Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex"]
["YLR395C","COX8",-22.62044,"Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"]
["YHR004C","NEM1",-22.734139,"Protein of the nuclear envelope required for the spherical shape of the nucleus; required for normal sporulation"]
["YML013W","SEL1",-22.772727,"UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, has a ubiquitin-associated (UBA) domain, interacts with ubiquitylated proteins in vivo, and is required for degradation of a ubiquitylated model substrate"]
["YER005W","YND1",-22.95035,"Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p"]
["YBR175W","SWD3",-23.240712,"Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5"]
["YPL227C","ALG5",-23.283747,"UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum"]
["YNL252C","MRPL17",-23.510036,"Mitochondrial ribosomal protein of the large subunit"]
["YLL041C","SDH2",-23.653652,"Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone"]
["YFR031C-A","RPL2A",-23.840194,"Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures"]
["YHR051W","COX6",-24.042563,"Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels"]
["YLR113W","HOG1",-24.256364,"Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p"]
["YJR120W","",-24.444231,"Putative protein of unknown function; mutation causes decreased expression of ATP2, which encodes the beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, and results in impaired respiration"]
["YDR323C","PEP7",-24.4775,"Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance"]
["YLL043W","FPS1",-24.576,"Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite"]
["YKL074C","MUD2",-24.802418,"Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65"]
["YNL052W","COX5A",-24.810257,"Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth"]
["YCL010C","SGF29",-24.849477,"SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex"]
["YPR084W","",-25.21921,"Putative protein of unknown function "]
["YBL083C","",-25.57731,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3"]
["YEL042W","GDA1",-25.597102,"Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate"]
["YMR245W","",-25.991692,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data "]
["YMR275C","BUL1",-26.015267,"Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases"]
["YIL070C","MAM33",-26.023411,"Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R"]
["YML081C-A","ATP18",-26.184397,"Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms"]
["YJR129C","",-26.201487,"Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"]
["YDL068W","",-26.263529,"Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data"]
["YFL018C","LPD1",-26.342868,"Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes"]
["YMR294W","JNM1",-26.920792,"Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B"]
["YPL172C","COX10",-27.059607,"Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders"]
["YJL128C","PBS2",-27.564026,"MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress"]
["YPR173C","VPS4",-28.185874,"AAA-type ATPase required for efficient late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; cytoplasmic protein that is also associated with an endosomal compartment"]
["YDR230W","",-28.345992,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 "]
["YBL045C","COR1",-28.40114,"Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain"]
["YJL022W","",-28.480132,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 "]
["YLR239C","LIP2",-28.492378,"Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups"]
["YMR207C","HFA1",-28.498876,"Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis"]
["YDR289C","RTT103",-28.648084,"Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition"]
["YPR146C","",-28.746032,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YPL017C","",-28.83099,"Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family"]
["YOL067C","RTG1",-28.840649,"Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus"]
["YDR377W","ATP17",-29.192926,"Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YKL064W","MNR2",-29.365695,"Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations"]
["YCR034W","FEN1",-29.526795,"Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway"]
["YOR200W","",-29.641423,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c"]
["YBR221C","PDB1",-29.862661,"E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria"]
["YJL193W","",-29.984295,"Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect"]
["YAR003W","SWD1",-30.1222,"Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7"]
["YOR002W","ALG6",-30.271335,"Glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease"]
["YLR204W","QRI5",-30.346979,"Mitochondrial protein of unknown function"]
["YDL183C","",-30.579255,"Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene"]
["YKL167C","MRP49",-30.658363,"Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"]
["YDL142C","CRD1",-30.694039,"Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function"]
["YDL069C","CBS1",-30.877294,"Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"]
["YDR293C","SSD1",-30.938865,"Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence"]
["YPR191W","QCR2",-30.97786,"Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme"]
["YHR179W","OYE2",-31.186389,"Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism"]
["YDR512C","EMI1",-31.283904,"Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation"]
["YPR061C","JID1",-31.362157,"Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae"]
["YER110C","KAP123",-31.603524,"Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1"]
["YDR414C","ERD1",-31.707423,"Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)"]
["YHR030C","SLT2",-32.461153,"Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway"]
["YGR233C","PHO81",-32.568807,"Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; required for derepression of PHO5; transcriptionally regulated by Pho4p and Pho2p"]
["YCR071C","IMG2",-32.965739,"Mitochondrial ribosomal protein of the small subunit"]
["YJL154C","VPS35",-33.200913,"Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps26p and Vps29p that selects cargo proteins for endosome-to-Golgi retrieval"]
["YNL054W","VAC7",-33.4018,"Integral vacuolar membrane protein involved in vacuole inheritance and morphology; may function to regulate Fab1p kinase activity"]
["YJL053W","PEP8",-33.685897,"Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport"]
["YER129W","SAK1",-34.474804,"Upstream kinase for the SNF1 complex; partially redundant function with Elm1p and Tos3p; members of this family of kinases have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"]
["YNR006W","VPS27",-34.48688,"Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)"]
["YGR257C","MTM1",-34.798611,"Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor"]
["YLR423C","ATG17",-34.930851,"Protein that interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway"]
["YOR266W","PNT1",-35.381862,"Mitochondrial inner membrane protein involved in export of proteins from the mitochondrial matrix; overexpression of PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine, and deletion confers increased sensitivity"]
["YBL099W","ATP1",-35.483636,"Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"]
["YLR015W","BRE2",-35.526971,"Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L"]
["YOL089C","HAL9",-35.642081,"Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression"]
["YDR120C","TRM1",-36.66943,"tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments"]
["YLR393W","ATP10",-37.045902,"Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6"]
["YGL244W","RTF1",-37.717054,"Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance"]
["YJR050W","ISY1",-37.899806,"Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest"]
["YER072W","VTC1",-38.381595,"Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase"]
["YGL136C","MRM2",-39.004608,"Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ"]
["YHR082C","KSP1",-39.061538,"Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation"]
["YEL024W","RIP1",-39.264463,"Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration"]
["YHR041C","SRB2",-39.284585,"General transcription factor, subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance"]
["YOR078W","BUD21",-39.559678,"Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern"]
["YPL060W","LPE10",-39.950957,"Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p"]
["YOR216C","RUD3",-40.056452,"Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1"]
["YNL098C","RAS2",-40.336759,"GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes"]
["YDR507C","GIN4",-40.681704,"Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p"]
["YJL209W","CBP1",-41.887287,"Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p"]
["YOR037W","CYC2",-41.890811,"Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)"]
["YLR038C","COX12",-41.939909,"Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assembly"]
["YKL055C","OAR1",-42.375706,"Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p"]
["YJR034W","PET191",-43.265152,"Protein required for assembly of cytochrome c oxidase"]
["YPR197C","",-43.330645,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YDL077C","VAM6",-43.373904,"Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p"]
["YOR051C","",-43.667995,"Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"]
["YMR098C","ATP25",-43.680233,"Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene"]
["YNR045W","PET494",-44.166058,"Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane"]
["YPL205C","",-44.188462,"Hypothetical protein; deletion of locus affects telomere length"]
["YOL072W","THP1",-44.203846,"Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding"]
["YML030W","",-44.804949,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential gene"]
["YKL041W","VPS24",-45.272926,"One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway"]
["YNL001W","DOM34",-45.445312,"Probable RNA-binding protein, functions in protein translation to promote G1 progression and differentiation, required for meiotic cell division"]
["YDR071C","PAA1",-45.515898,"Polyamine acetyltransferase; acetylates polyamines such as putrescine, spermidine and spermine; may be involved in transcription and/or DNA replication via regulation of levels of polyamines bound to chromosomal DNA"]
["YIL065C","FIS1",-45.68275,"Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division"]
["YDL067C","COX9",-45.697774,"Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"]
["YNL224C","SQS1",-46.09068,"Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles "]
["YIL053W","RHR2",-46.310345,"Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress"]
["YMR121C","RPL15B",-46.611979,"Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA"]
["YOR350C","MNE1",-47.009982,"Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase"]
["YAL026C","DRS2",-47.247788,"Integral membrane Ca(2+)-ATPase involved in aminophospholipid translocation; required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption; mutation affects maturation of the 18S rRNA /// Questionable ORF from MIPS"]
["YGR174C","CBP4",-47.376222,"Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p"]
["YMR315W","",-47.520661,"Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site "]
["YKR006C","MRPL13",-48.27027,"Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"]
["YOR330C","MIP1",-48.294843,"Catalytic subunit of the mitochondrial DNA polymerase"]
["YGL232W","TAN1",-48.475963,"Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA"]
["YER041W","YEN1",-49.257367,"Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p"]
["YPL174C","NIP100",-49.66766,"Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)"]
["YJL046W","",-49.813392,"Putative protein of unknown function, predicted to encode a lipoate-protein ligase A family member; deletion mutant has a respiratory growth defect"]
["YBR174C","",-49.841379,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective"]
["YNR007C","ATG3",-50.05293,"Protein involved in autophagy; E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy"]
["YPL098C","MGR2",-50.6975,"Protein required for growth of cells lacking the mitochondrial genome"]
["YJL095W","BCK1",-51.754324,"Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p"]
["YLR201C","COQ9",-52.445887,"Mitochondrial inner membrane protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; exhibits genetic interaction with ABC1, suggesting a possible common function"]
["YDL076C","RXT3",-52.461283,"Protein of unknown function, may be involved in chromatin silencing"]
["YKL011C","CCE1",-52.535,"Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA"]
["YKL109W","HAP4",-52.949396,"Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex"]
["YBR041W","FAT1",-53.095238,"Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids"]
["YDL100C","GET3",-53.248975,"ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress"]
["YDR322W","MRPL35",-53.441667,"Mitochondrial ribosomal protein of the large subunit"]
["YMR263W","SAP30",-53.651622,"Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance"]
["YKL137W","",-54.112882,"Putative protein of unknown function; mutation results in growth defect on a non-fermentable (respiratory) carbon source"]
["YHL038C","CBP2",-55.094018,"Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene"]
["YHR116W","COX23",-56.053678,"Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p"]
["YKL208W","CBT1",-56.544715,"Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p"]
["YAL002W","VPS8",-56.844641,"Membrane-associated hydrophilic protein that interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization; required for localization and trafficking of the CPY sorting receptor; contains a RING finger motif"]
["YBR133C","HSL7",-57.326409,"Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p"]
["YPL132W","COX11",-58.314286,"Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p"]
["YLR232W","",-58.334448,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5"]
["YML117W","NAB6",-58.640657,"Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data"]
["YKL155C","RSM22",-58.970655,"Mitochondrial ribosomal protein of the small subunit"]
["YDR372C","VPS74",-59.229167,"Non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus"]
["YJR075W","HOC1",-59.233411,"Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele"]
["YDR231C","COX20",-60.576923,"Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase"]
["YDR529C","QCR7",-62.904703,"Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly"]
["YHL009C","YAP3",-64.024691,"Basic leucine zipper (bZIP) transcription factor"]
["YOR333C","",-64.511081,"Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth "]
["YBR134W","",-64.926171,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YDL104C","QRI7",-65.954887,"Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica"]
["YHL005C","",-67.513754,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W"]
["YDR518W","EUG1",-67.612621,"Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER"]
["YJL166W","QCR8",-69.105769,"Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p"]
["YMR151W","YIM2",-71.617251,"Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1"]
["YOR036W","PEP12",-72.25641,"Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin"]
["YOL087C","",-74.12574,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid "]
["YDR316W","OMS1",-74.716069,"Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations"]
["YAL044C","GCV3",-75.688073,"H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm"]
["YNR042W","",-77.085299,"Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2"]
["YGR062C","COX18",-77.273576,"Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassa"]
["YGR222W","PET54",-77.543025,"Protein required for splicing of the COX1 intron AI5 beta; also specifically required, together with Pet122p and Pet494p, for translation of the COX3 mRNA; located in the mitochondrial inner membrane"]
["YBR084W","MIS1",-78.464687,"Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase"]
["YKL087C","CYT2",-78.654912,"Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1"]
["YMR158W","MRPS8",-80.82069,"Mitochondrial ribosomal protein of the small subunit"]
["YML110C","COQ5",-83.648794,"2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; located in mitochondria"]
["YLL039C","UBI4",-86.856759,"Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response"]
["YLL009C","COX17",-86.965812,"Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase"]
["YGL235W","",-89.908003,"Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 "]
["YPR149W","NCE102",-89.908537,"Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)"]
["YOR334W","MRS2",-89.929505,"Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns"]
["YMR244C-A","",-91.586085,"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene"]
["YMR138W","CIN4",-93.586957,"GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl"]
["YNR041C","COQ2",-95.788235,"Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis"]
["YOL096C","COQ3",-98.746988,"O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex"]
["YML129C","COX14",-105.015306,"Mitochondrial membrane protein, required for assembly of cytochrome c oxidase"]
["YGL237C","HAP2",-110.696203,"Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding"]
["YNR036C","",-114.147727,"Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli and human mitochondrial S12 ribosomal proteins"]
["YOR125C","CAT5",-117.321973,"Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis, essential for several other metabolic pathways including respiration and gluconeogenic gene activation"]
["YDR332W","",-121.075878,"Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci"]
["YER058W","PET117",-122.969957,"Protein required for assembly of cytochrome c oxidase"]
["YGL250W","",-123.582931,"Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus"]
["YLR067C","PET309",-125.015625,"Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane"]
["YIL157C","",-129.285041,"The authentic, non-tagged protein was localized to the mitochondria"]
["YER141W","COX15",-133.435897,"Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase"]
["YPL202C","AFT2",-137.123596,"Iron-regulated transcriptional activator, required for iron homeostasis and resistance to oxidative stress; similar to Aft1p"]
["YDR494W","RSM28",-138.273649,"Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation"]
["YJR059W","PTK2",-143.035264,"Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake"]
["YDR337W","MRPS28",-144.553977,"Mitochondrial ribosomal protein of the small subunit"]
["YMR023C","MSS1",-150.84466,"Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3"]
["YNL136W","EAF7",-151.635285,"Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A"]
["YGR112W","SHY1",-156.098776,"Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster"]
["YDL074C","BRE1",-157.375,"E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79), contains RING finger domain"]
["YJL155C","FBP26",-166.323755,"Fructose-2,6-bisphosphatase, required for glucose metabolism"]
["YJL141C","YAK1",-166.52381,"Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal"]
["YEL062W","NPR2",-172.655063,"Regulator of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences"]
["YJR144W","MGM101",-203.063174,"Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage"]
["YNL170W","",-222.181818,"Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data"]
["YGL129C","RSM23",-223.047619,"Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p"]
["YPL215W","CBP3",-243.923077,"Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p"]
["YFL033C","RIM15",-263.801966,"Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; originally identified as a regulator of IME2"]
["YAL056W","GPB2",-267.8,"Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p, has signaling role in response to nutrients; involved in regulation of pseudohyphal growth through cAMP levels; homolog of Gpb1p"]
["YOL027C","MDM38",-270.315603,"Mitochondrial inner membrane protein, required for K+/H+ exchange and for normal mitochondrial morphology and inheritance; associates with mitochondrial ribosomes; human ortholog Letm1 is implicated in Wolf-Hirschhorn syndrome"]
["YAL039C","CYC3",-273.454545,"Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-Cyc1p in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)"]
["YDR204W","COQ4",-280.619792,"Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex"]
["YNL070W","TOM7",-285.258407,"Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex"]
["YIL077C","",-344.783217,"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"]
["YFR033C","QCR6",-347.427083,"Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1"]
["YPL013C","MRPS16",-360.400356,"Mitochondrial ribosomal protein of the small subunit"]
["YBR037C","SCO1",-374.052023,"Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins"]
["YKL037W","",-396.082803,"Putative protein of unknown function"]
["YOR354C","MSC6",-413.953125,"Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to mitochondria; msc6 mutants are defective in directing meiotic recombination events to homologous chromatids"]
["YIL098C","FMC1",-414.966418,"Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase"]
["YPR134W","MSS18",-463.883588,"Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions"]
["YJL003W","COX16",-509.936508,"Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase"]
["YHR189W","PTH1",-919.222973,"One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration"]