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["Supplementary Material (ESI) for Molecular BioSystems\nThis journal is (c) The Royal Society of Chemistry, 2011"]
["Supplemental material for:"]
[]
["A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation"]
[]
[]
[]
["Manuel Liebeke1#, Kirsten Dörries1#, Daniela Zühlke2#, Jörg Bernhardt2, Stephan Fuchs2, Jan Pané-Farré2, "]
["Susanne Engelmann2, Uwe Völker3, Rüdiger Bode2, Thomas Dandekar4, Ulrike Lindequist1, Michael Hecker3 and Michael Lalk1*"]
[]
[]
["1Institute of Pharmacy, 2Institute for Microbiology and 3Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University of Greifswald, F.-L.-Jahn-Str. 17, D‑17487 Greifswald, Germany, D‑17487 Greifswald, Germany"]
["4Bioinformatik, Biozentrum, Am Hubland, D-97074 University of Wuerzburg, Germany"]
[]
[]
["#These authors contributed equally to this work."]
[]
[]
["Running title: OMICs analysis of glucose starved S. aureus"]
[]
["Keywords: glucose starvation, metabolism, metabolome, proteome, Staphylococcus aureus COL"]
[]
[]
["*Corresponding author. Mailing address: Institute of Pharmacy, Ernst-Moritz-Arndt-University of Greifswald, F.-L.-Jahn-Str. 17, D-17487 Greifswald, Germany. Phone: +49-3834-864867, FAX: +49-3834-864885. E-mail: lalk@uni-greifswald.de"]

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["Table S1","data for fig.1"]
["Distance matrix for all analyzed metabolites and central pathway proteins was used to calculate distances between two variables.  "]
["High similarity between two variables is shown by orange colored boxes (higher 0.9 correlation)."]
["A high inverse similarity between variables is shown by blue colored boxes (lower -0.9 correlation)."]
["Distance Metric: Pearson Correlation"]
["Abbreviations for proteins and metabolites see table S4"]
[]
["#"]
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["Uracil",-0.5367162,0.19722967,-0.33734024,0.037426937,-0.27354532,-0.3882595,-0.4525652,-0.041337784,0.07901068,0.06327728,0.021980898,0.1246213,-0.32446998,-0.4474154,0.04356442,-0.6575858,-0.5706123,0.037381765,-0.3696445,-0.62965095,-0.62558365,-0.67959994,-0.50912225,-0.30180216,-0.12556092,-0.46593603,-0.17479102,-0.5311651,-0.099428795,-0.5342717,-0.17183545,-0.24062459,0.16915831,-0.78080773,-0.75755286,-0.19787028,-0.6923801,0.030299263,-0.19182907,-0.027971823,-0.323444,0.023284271,0.035947442,-0.25969866,-0.053215135,-0.36238748,0.019540204,-0.6914848,-0.27658498,-0.6583096,-0.3996926,-0.4486355,-0.6068381,-0.6295887,-0.7031192,-0.29219565,-0.07464703,0.18768317,-0.13599966,0.046685204,-0.06961699,0.42042282,0.40533885,0.53810304,-0.15506496,0.12413785,-0.050386246,-0.33899453,-0.3472655,-0.20411648,0.6518424,0.49996933,0.3937284,0.36034536,0.4933966,0.51697683,0.71142447,0.1866407,0.3703907,0.085972704,0.31994757,-0.17441897,0.12759471,0.43442595,0.34040856,-0.035557825,0.20387852,0.12865226,0.44163606,0.31244856,0.290425,-0.17308944,0.11218149,-0.16284889,0.40536466,0.37150744,0.68015987,0.08806652,0.0070562544,0.6238156,0.50907034,0.123142324,0.06194207,-0.099857464,0.4106892,0.45491475,0.5250269,0.54529285,0.71212125,0.4774763,0.31280163,0.6561116,0.12746559,0.6905546,-0.10634714,0.43105984,0.3464245,0.47637293,0.12439367,0.36798406,0.5268723,0.638385,0.2951927,0.37195978,0.31634542,0.4225885,0.070560895,0.506778,0.08378482,0.0647149,0.28949392,0.48880625,0.21701054,0.20646301,-0.032518405,0.5777497,0.45227936,0.3930933,0.20001437,0.41327202,-0.041388,0.22599158,0.15372896,0.4163402,0.29757324,0.30843762,0.12789865,0.09679042,0.26927632,-0.034002364,-0.3050453,0.05922266,-0.20536573,-0.5839209,-0.575032,-0.43004346,-0.42683402,-0.38937572,-0.46352163,-0.48793724,0.18075702,0.3693662,0.13474683,0.013874423,-0.009701722,-0.65575284,0.3300978,0.4755976,0.5175318,0.045927223,0.34563372,0.17494582,0.37690604,0.2780023,0.2837431,0.6468807,0.44111603,0.2730807,0.60252756,0.2687975,0.8530486,0.30783483,0.3945522,0.5808636,0.42853156,0.5350304,0.61050993,0.3100755,0.29825813,0.24627906,0.3696998,0.67633593,0.8813242,0,0.6008787]
["GDP",-0.5809631,0.32331598,-0.49928403,0.08032342,-0.5804829,-0.46591988,-0.4710952,-0.1575782,0.10877999,0.10994975,-0.048414078,0.006321166,-0.5988728,-0.6187874,-0.07913236,-0.7827753,-0.6624784,-0.48620972,-0.29827362,-0.5513125,-0.550783,-0.7418369,-0.80440813,-0.64672565,-0.087393135,-0.66506135,-0.092345156,-0.74263006,0.07199208,-0.59083974,-0.45360002,-0.39019567,0.12605542,-0.7151695,-0.58646613,-0.40510193,-0.63167953,-0.14262635,-0.043644227,-0.61447096,-0.37359613,0.06179212,-0.07800292,-0.29654753,-0.48458925,-0.5564049,-0.060487602,-0.64518696,-0.6116732,-0.7553757,-0.8136999,-0.54440105,-0.72690064,-0.79421705,-0.488993,-0.50506854,-0.56798023,-0.41113022,-0.54300195,-0.5580711,-0.692252,-0.278019,0.61036813,0.717693,0.1067588,-0.06220913,0.19847347,0.24199349,0.10870989,0.20064035,0.6077356,0.6369874,0.4867192,0.6168211,0.50400263,0.54964733,0.8194695,0.4502519,0.2582487,0.008297122,0.42215317,0.2751297,0.37018466,0.2551993,0.16784059,-0.15667494,0.40168604,-0.26395515,0.6261951,0.59200615,0.27628428,0.11443156,0.5779115,0.012568023,-0.08067422,0.15318908,0.4207243,0.13657345,0.093766004,0.34387475,0.48383313,0.32044375,0.1850619,0.14718983,0.4912003,0.45385942,0.5071765,0.76532567,0.7796737,0.5389104,0.40250707,0.61750615,0.07939751,0.91244,0.16739541,0.52865237,0.4383435,0.44498798,0.18892446,0.4353549,0.7404986,0.6064851,0.16969408,0.536881,0.51601297,0.52099466,0.17399688,0.43567595,0.26823553,0.17617084,0.47952914,0.4618468,0.08873384,0.21893774,0.18553331,0.58657795,0.17677225,0.409834,0.32326627,0.24928452,0.15539452,0.32520914,0.4200111,0.7056695,0.411901,0.34885627,0.22544506,0.30915895,0.36107647,0.13183856,-0.38179713,-0.1450789,0.13505091,-0.32418007,-0.13803682,-0.09026824,-0.5361272,-0.28359613,-0.055227805,-0.5345983,0.23277244,0.41392377,0.21481574,0.20902908,0.18201524,-0.5107632,0.29390612,0.5602925,0.3437421,-0.2266654,0.3169609,0.49799505,0.57285386,0.44169292,0.29465178,0.8268107,0.4341558,0.3565439,0.6411244,0.43669996,0.33727074,0.6317258,0.41170537,0.30570248,0.6752939,0.81287724,0.60724163,0.5015897,0.47112557,0.625142,0.45444378,0.8293879,0.63991475,0.6008787,0]

{"sheet":"Tab. S2 a","index":2,"n_rows":35,"n_cols":21,"rows_kept":35,"cut":false,"hidden":false,"merged":[[5,11,6,14],[5,15,6,20],[5,3,6,10]],"flags":["formulas_cached_only"]}
["Tab. S2 a: "]
["Extracellular metabolite concentrations [mM] for CDM and nine sample time points (see fig.2 for growth curve) determined with 1H-NMR analysis. Data represent mean values of 3 biological replicates. "]
["CDM = chemical defined medium, SD = standard deviation."]
[]
[]
[null,null,null,"exponential phase",{"$nulls":7},"transient phase",null,null,null,"stationary phase"]
[]
["Metabolite","CDM","SD","t0","SD","t1","SD","t3","SD","t5","SD","t7","SD","t9","SD","t13","SD","t19","SD","t24","SD"]
["Acetate",0.491,0.029115525497576726,2.179,0.1930062475672761,2.27,0.5901067610822646,3.345,0.7698550532243108,4.561,0.5664627963070417,6.284,0.9870833209511787,6.166,1.5986980360046117,5.729,0.7793628854230916,4.761,1.0212573071097197,4.428,1.0501133602735526]
["Acetoin",0,0.0015900943368240769,0.066,0.00812803943149879,0.074,0.023610039707717533,0.129,0.04472222350241542,0.191,0.0322670199274738,0.289,0.07791362862169864,0.308,0.09351185432874272,0.341,0.05763429903278068,0.362,0.09242623694060037,0.373,0.10334543712714139]
["Alanine",1.519,0.10218196562995087,1.417,0.06098386343944309,1.173,0.354345655716279,1.02,0.24075703307484062,0.785,0.18262680327651762,0.552,0.1614700027094816,0.406,0.11645124290878142,0.311,0.060351707308078865,0.213,0.04266835712796998,0.208,0.054583425368879196]
["Aspartate",1.274,0.059788660296080834,1.24,0.0328034979079975,1.025,0.31334589705308075,0.949,0.22254552888117063,0.811,0.15639050858348194,0.742,0.11709456562966608,0.678,0.15467572264256568,0.672,0.05059077509783958,0.585,0.10724666952870893,0.551,0.11334401296495578]
["2,3-Butanediole",0,0.0004319927284500313,0.017,0.004264862981386394,0.016,0.009144804877634069,0.029,0.011842365420387928,0.055,0.016726901797702982,0.105,0.02810059474459565,0.099,0.03043337816033566,0.074,0.0109138435599014,0.047,0.01091889503338136,0.041,0.010922308306855293]
["Citrate",0.154,0.01562263322074742,0.182,0.00975885463310117,0.151,0.052312932256278664,0.161,0.03975277136565452,0.167,0.02422520085056034,0.197,0.036066152501340855,0.192,0.052237824119597445,0.202,0.027611014446231333,0.182,0.04480295421342218,0.184,0.05382095473651501]
["Ethanol",0.004,0.00632717946639733,0.02,0.004679575301242641,0.015,0.005097381680823977,0.024,0.006057406623300117,0.039,0.01865158773402415,0.038,0.009121730921267073,0.04,0.016378031017188845,0.047,0.016334490350176218,0.048,0.020748342102442797,0.052,0.02723801892575887]
["Formate",0,0.017427634980751405,0,0.01425798200290036,0,0.01755753879131907,0,0.00999713701628092,0,0.01277707856242897,0,0.009841252443599723,0,0.01210157874747711,0,0.012309424844385373,0,0.010880482928141049,0,0.009815271681486187]
["Fumarate",0,0,0,0,0,0,0,0,0,0,0,0.00022170031643565103,0.004,0.007468605269170164,0.012,0.005054760751014825,0.007,0.006488939146732691,0.003,0.0030080930433718806]
["Glucose",7.173,0.3797946717635703,5.94,0.2501158185721201,4.685,1.5666857567489383,3.565,0.9401025825408659,1.815,0.8317898857884719,0.266,0.46099043985729826,0,0,0,0,0,0,0,0]
["Glutamate",1.417,0.010464483682915365,1.389,0.03775957436531893,1.162,0.33110058944563925,1.124,0.27165172248901776,1.013,0.16963768920850106,0.963,0.1632428269289341,0.878,0.20388584825521852,0.825,0.07025697087300048,0.634,0.12463939192225632,0.51,0.11843781651672673]
["Histidine",1.113,0.04183158465800816,1.228,0.07387129330801914,1.008,0.35074809518370886,1.019,0.2723308838527127,0.961,0.14352009798282486,1.016,0.17383507765983294,0.969,0.22592959915646235,0.951,0.08803005694079777,0.865,0.1899625862505567,0.779,0.191861880593827]
["Isoleucine",0.948,0.07621735543004633,0.97,0.008978439800433117,0.816,0.24516660611969598,0.782,0.1773338814390802,0.703,0.12069194000118623,0.664,0.11614716265905929,0.588,0.14341853168698232,0.508,0.057083670662020185,0.38,0.08453046477454154,0.329,0.07123394226946875]
["Lactate",0.152,0.10355906032308317,0.3,0.09266646602196515,0.368,0.15178093778534876,0.376,0.1959420932954428,0.509,0.06903263413053255,0.673,0.12425726427456846,0.647,0.17138498833036703,0.577,0.09801828515639324,0.5,0.13230596443471462,0.401,0.09135677848413884]
["Leucine",1.324,0.21738103936406175,1.307,0.04932981426074911,1.155,0.4273845436196768,1.09,0.23556834103928248,0.963,0.1998474724008289,0.976,0.18757534026358516,0.947,0.23752966904157452,1.011,0.1422995086955677,0.986,0.23369027627396052,0.963,0.2577585537377957]
["Lysine",1.134,0.24001095396877095,1.131,0.04625580477085826,0.957,0.2932452259521887,0.909,0.22475160125959,0.833,0.1361260084673391,0.798,0.13449668237079376,0.725,0.1719140800843552,0.722,0.0651903606754848,0.655,0.13324941735332285,0.624,0.1386260046627253]
["2-Methylbutyrate",0.006,0.006706616136323892,0.068,0.034898683356252874,0.066,0.03799561685247392,0.074,0.040260238449368387,0.094,0.0258763927161419,0.114,0.034178243079479656,0.122,0.04894034838453851,0.116,0.0319915551356917,0.128,0.04170859263988661,0.12,0.04052201993978087]
["Ornithine",0.076,0.13094310666019215,0.001,0.001195180665207555,0.003,0.004910429647442799,0,0.0005976231365962918,0.004,0.004472066713066994,0.004,0.006271850667845828,0.005,0.0063592870530025025,0.012,0.008318592128479442,0.029,0.013600947577282975,0.043,0.019997374202629727]
["2-Oxoglutarate",0,0.006681025146278502,0.042,0.01891115742095128,0.039,0.02969693450088746,0.073,0.04401443037516222,0.129,0.0625117922875356,0.193,0.040169339753722534,0.094,0.038223050064718815,0.053,0.01671921592808709,0.046,0.01753590299214727,0.052,0.02177304124370317]
["Phenylalanine",1.062,0.022739100823251507,1.072,0.013396912657399833,0.894,0.26512723588166187,0.901,0.21480298950433585,0.862,0.12848664154786574,0.88,0.15027835117291422,0.843,0.2029072908220655,0.877,0.0960113422010656,0.834,0.18336548947730055,0.819,0.20243967768201931]
["Proline",0.872,0.06260688779998563,0.9,0.09179935293889603,0.728,0.25992556780740156,0.763,0.10306835207763769,0.729,0.12198596148737745,0.786,0.09851186933562818,0.762,0.18509972771454836,0.821,0.0787295802097293,0.647,0.1651762949094091,0.583,0.20465187318957007]
["Pyruvate",0.015,0.0028166602564029643,0.052,0.013401115625200723,0.05,0.024911136064017615,0.071,0.01516867907894426,0.102,0.012955210341789194,0.075,0.05040190249385435,0.025,0.007523049581120677,0.026,0.0030529452992151688,0.022,0.004164231621800114,0.024,0.006924110051118478]
["Serine",1.479,0.31299896565324464,1.271,0.21586327391430052,1.002,0.41001612227447864,0.77,0.14222121914468316,0.549,0.14491356458247787,0.352,0.11126716901224722,0.243,0.0895297703280869,0.193,0.023838294297201735,0.19,0.05405798761515282,0.208,0.07495118461372045]
["Succinate",0.001,0.0009929572309520687,0.022,0.0044521013297093796,0.022,0.010445892060398686,0.035,0.01578605649576549,0.059,0.019981869633808068,0.145,0.09397382104707408,0.223,0.09564317716942757,0.229,0.07452982979778969,0.168,0.05577643390973919,0.125,0.044190275425567326]
["Threonine",1.102,0.08327228215318802,1.041,0.02840046698559728,0.794,0.2632341738832557,0.785,0.10852005724749654,0.623,0.10493308189031708,0.498,0.07453997467802125,0.342,0.1061109287491159,0.111,0.010233947185714805,0.089,0.02045408822216232,0.145,0.08019545856842519]
["Tryptophan",1.012,0.035071632767809904,1.049,0.03075025975500033,0.882,0.2591728162828807,0.899,0.21058171555241884,0.914,0.13749897335980316,0.914,0.14784640484300002,0.9,0.20631133760654086,0.942,0.11889242711375834,0.92,0.20747572129046854,0.905,0.22665813866923037]
["Valine",1.222,0.040663245996847834,1.214,0.19711799917815825,1.022,0.2935861434059854,1.186,0.28240697986239666,1.188,0.17355594609519984,1.29,0.23157904325521292,1.259,0.31655711250104634,1.286,0.15785700039909553,1.214,0.27253605096390515,1.178,0.29630742316891096]

{"sheet":"Tab. S2 b","index":3,"n_rows":47,"n_cols":19,"rows_kept":47,"cut":false,"hidden":false,"merged":[[6,1,7,8],[6,9,7,12],[6,13,7,18]],"flags":["formulas_cached_only"]}
["Tab. S2 b:"]
["Relative intracellular metabolite values for nine sample time points (see fig.2 for growth curve), quantified and normalized to internal standard and CDW. Metabolites were determined with LC-MS analysis. Data represent mean values of 3 biological replicates. "]
["CDW = cell dry weight, SD = standard deviation."]
["* Metabolites were only identified by exact masses and not by analysis of standard compounds."]
[]
[]
[null,"exponential phase",{"$nulls":7},"transient phase",null,null,null,"stationary phase"]
[]
["Metabolite","t0","SD","t1","SD","t3","SD","t5","SD","t7","SD","t9","SD","t13","SD","t19","SD","t24","SD"]
["Acetyl-CoA",15.55,14.431697891543736,18.2,3.9890322682507993,1.145,0.9992969555735022,2.947,4.446768749725134,0.471,0.5150804173640459,0.239,0.2582593989915728,0.025,0.028311453470826538,0.06,0.05133981475324025,0.045,0.040878658695515914]
["Adenylosuccinate *",0.264,0.2051204317343025,0.219,0.05587961845105475,0.201,0.04700041732286152,0.132,0.04342841227279991,0.344,0.33915829888909094,0.229,0.20128863379678547,0.082,0.02874783119859017,0.35,0.32156285343006913,0.544,0.06703129293198987]
["Butyryl-CoA",0.266,0.13814370069805498,0.14,0.11680990196957315,0.231,0.14004846053644315,0.156,0.1568473526565337,0.345,0.1733989342694332,0.19,0.13841670159608502,0.302,0.323138932913732,0.438,0.43977152447555096,0.444,0.06289754893054508]
["CDP-Glycerol",12.633,2.002693661103083,12.146,2.8974502980397645,7.817,1.764394456811346,7.505,3.2310856352302797,4.495,0.9384688605610974,2.577,1.6802787283111922,2.194,1.0433077877387638,2.121,1.1420339886419812,2.653,0.279798442969725]
["CDP-Ribitol *",49.309,10.458016795046564,51.987,20.78684417176179,33.734,3.442660113029164,39.609,22.25155566196566,20.579,1.3944319399751137,13.874,9.735165756498148,12.85,6.320820683711616,17.636,10.761293098554443,21.727,6.74835940645336]
["dADP *",1.023,0.5540674638541332,1.088,0.8743730478140621,0.44,0.04289036374605048,0.37,0.10150559434961483,0.613,0.24053875840900757,0.921,0.2633287149494831,0.496,0.23426561411672936,0.711,0.2261010546473996,0.926,0.6232805292318278]
["dAMP *",0,0,0.057,0.09795381297456676,0.011,0.018534603738078775,0.006,0.009535988506053273,0.043,0.040275348706814956,0.063,0.06162484564420358,0.022,0.020840045983944722,0.062,0.05586745364206857,0.04,0.035173217254727475]
["dATP *",5.229,0.9652840154786327,4.777,0.5011211033971685,4.421,0.771714870884903,3.473,0.9008043931871693,4.045,0.7283455903885323,4.242,1.0043487630792818,3.332,1.0210311713463514,2.602,0.5960595295314443,2.059,0.4753065675147781]
["dCDP *",1.106,0.4515708701158404,0.802,0.3315372093884195,0.671,0.13154329876843965,0.673,0.3201160396564863,0.577,0.2608619583983209,0.479,0.16914498076294882,0.253,0.09794852695722758,0.277,0.11004380334084628,0.166,0.09874908114190392]
["dIMP *",0.217,0.2073724539801125,0.096,0.0632772492062246,0.208,0.07659823576737733,0.155,0.06440541221928792,0.118,0.0275088917393615,0.208,0.03863083388281043,0.121,0.10393913443884861,0.209,0.08363516721336016,0.255,0.07326375181459542]
["dTDP *",4.528,1.8213432709652717,3.673,2.0381367376372683,2.554,0.4815413275010383,1.831,0.7536458678152327,2.115,0.7572525345374375,2.489,0.9078733420130488,1.361,0.5820751444802538,1.948,0.5982437585998961,1.795,0.5879789142630071]
["dTTP *",32.341,2.511133739960341,30.45,3.1354180314424034,23.285,2.9312166815790817,15.973,4.4411501047292266,15.216,3.2681672517136136,12.745,2.6112578329261984,8.491,1.9257973519881688,7.969,1.8548767597435087,5.828,0.9495331231036822]
["Erythrose-4-P",1.664,0.47120912695105605,1.534,0.8861251756987095,0.452,0.4852606209240563,0.263,0.17492255610286134,0.202,0.18170364781201895,0.142,0.0876293696377052,0.118,0.06876006776746192,0.126,0.10110089858051922,0.186,0.08993783460325343]
["FGAR *",1.837,0.8390628881358658,0.659,0.2746945722360042,0.819,0.5547188192118652,0.592,0.27444695332897606,0.185,0.22231692820085655,0.041,0.0711391898438033,0.111,0.19262787018705857,0.062,0.10819027573134407,0,0.0006745342280027487]
["FMN",1.118,0.22560980221433405,0.889,0.13027671932525983,0.896,0.11275861460794506,0.636,0.07128386659526485,0.702,0.18775956741116318,0.905,0.26559973356445443,0.624,0.12783293156050868,0.736,0.22603062822220146,0.759,0.23681876014584297]
["GAR *",0.417,0.3150351418596179,0.382,0.36861367181821547,0.119,0.018195932833089994,0.301,0.37411299315836744,0.299,0.16416940300853772,0.212,0.17691428839475215,0.282,0.24565760990328667,1.733,1.4561544941885387,2.507,1.21794325244145]
["Glucono-1.5-lactone-6-P *",4.716,1.818089781151761,3.254,1.6605010853787732,2.61,0.6363996051832582,1.456,0.202116778224649,0.268,0.4174002306846002,0.015,0.02588183983349175,0.002,0.004061762480119973,0.004,0.006857521070332422,0,0.0007214583482116356]
["IDP",0.094,0.021379438025543346,0.08,0.0324302995068129,0.045,0.004245159297847401,0.032,0.012633884899834516,0.044,0.01872108867968902,0.042,0.014920847079072926,0.025,0.012159317710734772,0.036,0.008924551731917208,0.044,0.008683915730854478]
["NADH",0.245,0.19904848990826696,0.248,0.17295321857506324,0.071,0.05374411647147772,0.111,0.08964226304738844,0.036,0.02210335494558191,0.026,0.03618365437579738,0.005,0.008635654036577841,0.065,0.07985355201638639,0.006,0.009688303260784969]
["NADPH",3.59,3.122783466974187,3.727,1.913205140802807,0.389,0.3351497388398873,0.671,1.0901745852259899,0.17,0.1654044745521204,0.052,0.007739815042132712,0.096,0.03274048068213975,0.139,0.05189944621591484,0.199,0.03702468048449984]
["N-Carbamoyl-Aspartate *",0.135,0.09251539867005756,0.123,0.10492932113155139,0.086,0.03311997298584999,0.092,0.0776822690424451,0.009,0.006422276338867749,0.003,0.005588573772593195,0,0,0,0,0.01,0.017338462417183696]
["6-P-Gluconate",59.922,27.584533157389192,48.55,29.06574485403813,34.625,11.082792856726991,19.938,4.341483853511396,4.296,5.860233777295857,0.807,0.29477112360883084,0.446,0.13309047120292417,0.453,0.2991230464966706,0.454,0.17814394790500998]
["PRPP",1.949,0.25868121725377996,1.829,0.30881530609368235,1.912,0.2573015728733242,1.235,0.22239669932704406,0.569,0.7248648280265388,0.152,0.08394090703852132,0.107,0.03770923316861742,0.131,0.03465788285214861,0.086,0.05310209436637205]
["SA_1351.9663",1.511,1.190302466708785,0.781,0.44514167320162884,2.262,1.9132343987728762,1.158,1.4090565052882085,5.435,8.802521442317657,10.728,12.629469220616858,12.279,16.7224451390072,18.942,11.097345602443719,5.445,3.4606418925020606]
["SA_479.1138",1.276,0.6723017648211249,1.696,0.3626485554143535,0.925,0.31221899274981135,1.369,0.322672248163157,1.998,0.1602721674142616,12.591,7.670367819788092,73.023,37.677751649171846,182.388,9.265804275827815,197.574,55.64618193162917]
["SA_652.2098",6.977,0.855349303030051,5.806,1.1188755518322633,7.82,0.9411455538591997,7.14,2.4412111311067437,7.489,1.1356750366797617,11.217,2.082805411139965,18.176,9.007092429799819,38.536,7.621557876098969,38.376,10.831171153111292]
["SAICAR *",4.216,1.482033885830748,3.811,0.8876954285872418,1.888,0.761368148889456,1.236,0.5480702032939435,0.359,0.3914838737338658,0.016,0.013695091609515105,0.014,0.017136685144465886,0.022,0.038241794809702516,0.019,0.016261536142891133]
["Sedoheptulose-7-P",3.171,2.0506873553110427,2.077,1.462233346022403,1.769,0.49640748302771004,0.813,0.5285529307472289,0.297,0.44953440237846043,0.041,0.036386362777651636,0.024,0.0029214626862214487,0.156,0.13230727768907918,0.306,0.11818616361286771]
["Succinyl-CoA",0.688,0.07176693274920884,0.406,0.20246182756016357,0.892,0.4262971502348838,0.465,0.37263411433666044,1.389,0.7190901037967519,0.708,0.2855009077636768,0.605,0.47133995375298415,0.011,0.013013442616303198,0.024,0.01859915088986458]
["UDP-Glc/UDP-Gal",2.44,0.7468498228948437,2.183,0.6112662021256753,1.627,0.33073688533584167,1.682,0.6660541447041108,0.791,0.3323961248234351,0.21,0.12365171439025277,0.112,0.03875127846018186,0.123,0.08899926582033123,0.219,0.02608899772154998]
["UDP-GlcNAc",35.239,11.801587895265328,27.962,9.32591805229976,29.556,5.26591494604258,25.291,10.082009657770211,5.99,5.284615803415701,0.489,0.13260093759507624,0.665,0.1887827208733435,0.508,0.31859217339974377,0.645,0.2530872969110859]
["UDP-GlcNAcEP *",0.571,0.18290827227639123,0.481,0.15332196126411685,0.452,0.035085013134064806,0.384,0.1410211645164841,0.354,0.026638171611983907,0.524,0.2170766077719876,0.336,0.16987050027389014,0.53,0.2082935199951312,0.721,0.2152394912072003]
["UDP-ManNAcA *",35.792,13.461436869926704,30.531,12.419023618680542,25.732,2.3884028766472145,14.361,4.116678672423853,5.863,1.86662660581276,3.847,1.5485132240737771,1.4,0.5343346516777436,2.163,0.7981224853263753,2.841,0.602249625121121]
["UDP-MurNAc",4.023,1.2000492450647164,3.783,1.304740399412016,3.198,0.2363808539310676,2.461,0.9045480424971594,1.38,0.8405962637175044,0.447,0.1929900582701094,0.403,0.13217100635619855,1.768,0.9303761561525717,3.267,0.7152168628858061]
["UDP-MurNAc-Ala",2.225,1.7261798844702891,2.815,1.4032233847722053,2.594,0.7563776403505478,1.74,0.6610223561285558,0.608,0.6312278637923088,0.019,0.018402704889039317,0.01,0.004519680338208308,0.038,0.028637082488033583,0.064,0.041789681897732626]
["UDP-MurNAc-Ala-Glu",0.6,0.23112630952362379,0.645,0.22316211703910585,0.497,0.032424914505060756,0.362,0.14687881361296048,0.177,0.06193315193063704,0.146,0.059323404897157414,0.116,0.038652389410204005,0.104,0.03430352750403424,0.091,0.030346807598796873]
["UDP-MurNAc-Ala-Glu-Lys-Ala-Ala",1.521,0.8391860562054794,1.881,1.1649933780645205,2.08,0.8300767661483727,1.098,0.510743166168193,0.373,0.5701489469100273,0.004,0.00649836176896927,0.01,0.00875760749412997,0.012,0.012164961021953781,0.019,0.019895769799297844]
["XMP",0.003,0.0043122640955758846,0,0.00038258764774031515,0.002,0.000978472981127284,0.001,0.0007022976232766585,0,0.00032527835646259075,0,0.0003108824006777768,0,0.00023208953091062608,0,0.00027319341634786653,0,0.00021888376196002246]

{"sheet":"Tab. S2 c","index":4,"n_rows":64,"n_cols":19,"rows_kept":64,"cut":false,"hidden":false,"merged":[[5,1,6,8],[5,9,6,12],[5,13,6,18]],"flags":["formulas_cached_only"]}
["Table S2 c:"]
["Intracellular metabolite concentrations for nine sample time points (see fig.2 for growth curve), absolute quantified and normalized to CDW [µmol / g CDW]. Metabolites were determined with GC-MS and LC-MS measurements. Data represent mean values of 3 biological replicates."]
["CDW = cell dry weight, SD = standard deviation."]
[]
[]
[null,"exponential phase",{"$nulls":7},"transient phase",null,null,null,"stationary phase"]
[]
["Metabolite","t0","SD","t1","SD","t3","SD","t5","SD","t7","SD","t9","SD","t13","SD","t19","SD","t24","SD"]
["Adenine",0.3,0.10831852281924546,0.22,0.11886550806232715,0.2,0.10426256322784433,0.17,0.025919561659027767,0.27,0.11515161744351919,0.32,0.18825383382303393,0.4,0.27103020071235434,0.58,0.23097456473523983,0.53,0.24464495335622743]
["ADP",4.47,1.3203438968408996,3.87,1.8397734213873336,2.23,0.3512116792467367,1.68,0.8137025739432405,2.7,1.4280268280783623,2.45,1.0407916745389063,1.32,0.7978925191020788,2.11,0.725786621271392,2.68,0.63003275501489]
["Alanine",302.68,97.84309633785851,268.33,115.87560305066813,326.79,51.79187406683211,262.68,165.55978590860488,436.06,262.1903789392769,309.16,39.268943994327756,209.13,53.60066579365207,148.78,102.41432900723858,121.12,44.34237425646471]
["AMP",1.56,0.7007030499021824,1.71,0.9342218491268757,0.36,0.05138219518625819,0.52,0.35135102084146547,0.65,0.5423338218716977,0.77,0.33090542209311297,0.33,0.1958268733033676,0.91,0.7666502347983292,0.91,0.13870793058638833]
["Asparagine",0.2,0.06599353874043963,0.19,0.16025112704124378,0.21,0.08015374123876083,0.17,0.14387630874018303,0.26,0.06323032267929174,0.33,0.13029373293200097,0.37,0.1687664560369209,0.64,0.23396511293223293,0.53,0.1757077618641637]
["Aspartate",149.75,36.13909143924739,110.2,75.37927293657872,120.24,25.49255905029061,84.26,45.29959154620738,302.02,278.98579453201603,324.87,15.52139762242467,318.02,132.63316025458312,562.14,290.45858211405863,593.47,161.2127179808382]
["ATP",14.35,2.3696226752464615,12.77,1.1466134315349814,13.29,2.7662739904850016,9.45,2.0798733254023363,9.04,0.9611670482259503,6.66,1.2937269995018355,4.77,1.6561358595771285,4.44,0.5742087649630326,4.44,0.769599389673149]
["CDP",1.04,0.270232331438304,0.94,0.187427463977983,0.62,0.02475937631395448,0.58,0.19199057036822909,0.54,0.22003973768511434,0.47,0.14743473828869144,0.37,0.12065205594485139,0.84,0.4225745400418338,0.83,0.25478274059606576]
["Citrate",5.1,0.4429296968243252,5.13,2.032578274058939,5.79,1.086070295576174,4.56,3.798014946151858,3.56,1.4388046597840853,2.15,0.2973867485947207,1.5,0.3594542773182025,1.71,0.6464706248930134,2.34,1.3294684773447276]
["CMP",1.37,0.551010908642251,1.02,0.31765270945672763,0.51,0.3239737038132677,0.3,0.18744271107684973,0.32,0.10404157891507175,0.12,0.08656234041033076,0.21,0.04570133164362651,0.7,0.5851824022289729,0.61,0.29575714278834864]
["CTP",2.79,0.2537869503666699,2.51,1.0631035925074557,2.52,0.16448462163499286,1.69,0.6527684658058984,1.62,0.5279362631334208,0.96,0.25368058783562014,0.94,0.4534075043040997,1.59,0.4380559746063148,1.74,0.4833498658063636]
["Cysteine",0.88,1.2909607037934558,2,3.3612644399855864,1.74,2.7304636525280905,2.23,1.8701103936759886,2.02,1.9510281342450853,1.52,1.9988622587281983,2,2.1570111146765196,3.59,2.984096046571649,6.25,4.942537392556891]
["Dihydroorotate",0.19,0.15083357013705612,0.16,0.05350486438031442,0.14,0.060499883632733654,0.16,0.022997364262939208,0.12,0.08824571047251377,0.07,0.03680230849494351,0.11,0.03680699281825613,0.16,0.07306526088667023,0.11,0.0814571650082829]
["Erythrose",1.2,0.2848339485965765,0.83,0.34114406771324507,0.64,0.20851586257516116,0.57,0.22363124808400528,0.39,0.08655145953358782,0.14,0.016805442606362807,0.17,0.038346768311480275,0.33,0.09905047194455269,0.35,0.07513727695352776]
["FAD",0,0,0,0,0.02,0.030277253841421315,0.06,0.0767508376366305,0.11,0.05548759755677105,0.21,0.05886905099008797,0.16,0.05192754060093985,0.22,0.14995494895055042,0.27,0.12778803873735287]
["Fructose-1.6-bP",21.05,5.637582813050573,12.67,5.149269232235969,5.77,3.3167285359088896,2.99,2.1815238072484275,0.78,0.8340337719372116,0.25,0.052696955093418395,0.16,0.03120372975073965,0.16,0.01377698876487759,0.17,0.04323770187120965]
["Fructose-6-P",46.48,33.039812605683636,40.82,30.251120294406626,19.16,9.627074794375897,10.2,5.33583952131125,3.92,5.765011493504691,0.51,0.40205018199062975,0.52,0.907968432900185,0.37,0.6489364974919123,0.95,1.619168515803789]
["Fumarate",2.32,0.3761877819706628,1.78,1.2371425574598414,2.78,1.1419684288052496,1.98,0.9065761306521753,2.37,0.7798449021970377,2.85,1.0886782942058966,3.16,1.5321782042097758,4.32,2.1095981298208444,4.07,1.9133154095226153]
["GDP",0.38,0.09574605588537245,0.4,0.16231273052568163,0.21,0.013773931050757122,0.19,0.03750070488967628,0.15,0.04155701375038338,0.19,0.06257850294217626,0.15,0.0562989148968005,0.37,0.15806980768764706,0.44,0.09957313615265635]
["Glucose",39.12,30.790308970988235,6.55,2.716404272690993,10.22,11.809650772617283,1.04,0.4247200013595272,0.34,0.32926836346575034,0.1,0.04320813074926415,0.05,0.008368115087723539,0.04,0.008813564249950777,0.04,0.015055810552958022]
["Glucose-6-P",23.35,12.813828012975904,18.96,13.506753285133478,9.35,3.224948796739465,5.24,3.072068261759841,1.95,2.463505382738099,0.25,0.16239442772581938,0.14,0.06585962814883506,0.28,0.36225193104052883,0.55,0.6613248625471001]
["Glutamate",500.96,82.17500867260826,474.08,258.8259189784261,525.13,81.09747545431762,321.27,151.47708988058955,687.17,541.3808111912442,492.94,4.408424997052967,433.51,149.03016724742827,418.71,212.21664870836062,289.06,25.103884373229114]
["Glycerol",15.84,4.69402776727414,12.55,1.3083927631428571,9.48,4.104856769937465,5.93,2.7001820377649817,6.55,0.8271739355807539,4.02,0.3034788180768435,3.96,1.7539487073597582,5.52,2.9878044092502902,5.97,1.9341054898578904]
["Glycine",0.73,0.5187403579757915,1.16,1.1587179597651933,0.91,0.9893841567145532,0.25,0.24709682980545616,6.87,8.706712444037109,33.45,26.879860920536665,38.75,17.644563740891314,3.47,1.3002562717451116,1.36,0.13721579063283776]
["GMP",0.01,0.01965914173461472,0.08,0.08486979594956334,0,0,0.04,0.07176719807675239,0.04,0.032592179036431725,0.04,0.03658647888905102,0.05,0.017280982992553102,0.29,0.20470402182904301,0.29,0.11701956042891638]
["GTP",2.01,0.047631177137220294,1.88,0.3159016665847094,1.47,0.03313077821967517,0.96,0.3322429728961984,0.84,0.20830423129701153,0.69,0.08758445545341517,0.74,0.2634847791614403,1.11,0.14437292065960664,1.36,0.2985854511513982]
["Guanine",0.12,0.04830036832677445,0.07,0.03807693439366676,0.08,0.04204294496448003,0.05,0.01334377885616756,0.06,0.02772879861534772,0.1,0.04684826479586181,0.1,0.055713970272956465,0.16,0.09429437655969625,0.17,0.07414729455420876]
["Histidine",10.13,8.074083163316828,2.21,1.8325328813789343,4.71,2.024973256135888,2.44,0.9566155844812545,7.9,3.3812960474938603,16.16,4.3268313060435215,28.19,19.803148523170858,124.02,59.00011794180005,153.18,68.99602816528234]
["IMP",0.73,0.10923465209835977,0.62,0.12425769730367718,0.36,0.09852084099763231,0.27,0.051472831068633554,0.12,0.07566927646319681,0.06,0.005712612408754409,0.06,0.005951494203279488,0.07,0.029061083184395563,0.06,0.00500108886450446]
["Isoleucine",49.7,9.206214163598009,34.02,15.298326854706012,41.05,3.8788023159168565,30.92,19.268443242301803,47.68,23.057522270667537,24.92,5.370356060938061,21.19,5.97396274991609,25.49,15.064397391272447,20.18,3.5006800947106176]
["Lactate",17.05,5.21306503655451,14.7,4.3790437764812395,10.43,6.318550033189654,13.65,12.000874889064772,7.66,4.980842934532837,10.5,2.427751603120173,8.42,1.8789114082940255,8.55,3.986139053441777,5.83,1.4224197696375533]
["Leucine",44.46,8.478680279980926,29.63,13.870790945155935,34.79,3.1978809026900112,21.47,10.1705672912052,25.22,8.716231497917743,13.39,1.3446119863142545,11.94,3.3689996790181795,13.36,7.721575870641881,11.58,2.7326122324688527]
["Lysine",13.54,4.502763080164126,9.54,4.734939628166035,10.83,3.8297669271274852,7.71,1.149840097607374,58.57,79.67099896848323,152.16,121.9071564122904,298.38,89.06075088174349,537.32,49.12276156366075,741.52,197.1510260158174]
["Malate",0.36,0.11638484771759591,0.3,0.11710526610853017,0.23,0.022196536062901943,0.13,0.08146564096667559,0.21,0.03914995839908176,0.23,0.01524629809771725,0.23,0.05079523781119871,0.46,0.2501298200808196,0.61,0.1807442725403681]
["NAD+",1.05,0.2876639541985529,0.51,0.4171043839494285,0.59,0.21011315548319098,0.42,0.03651493669079676,0.33,0.2705932580716352,0.48,0.4175253740222882,0.34,0.3023910156519285,0.34,0.28518115457217497,0.84,0.2002824325253173]
["NADP+",2.82,1.2238012582182847,1.66,0.5128910244736065,2.34,0.33057198547787453,1.59,0.7033751643972386,1.24,0.17737412331113978,1.35,0.38406861231545886,0.84,0.5425602069701267,0.95,0.42817056524340913,1.07,0.45902490965543924]
["Ornithine",0.15,0.03441094211430585,0.1,0.033112158080921494,0.1,0.014353950744072442,0.09,0.04202381401682311,1.04,1.5241938404180333,4.84,3.0180529762133,11.69,3.7479496513585047,22.25,1.5507228736902599,25.68,5.4687632756600815]
["Orotate",0.05,0.011688641278723159,0.04,0.018901957836616648,0.04,0.00720652908429325,0.18,0.1874425595538916,0.06,0.08247173730601834,0.02,0.005231663422515934,0.02,0.010001796464296423,0.03,0.01365585907781525,0.02,0.012467820839125645]
["2-Oxoglutarate",0.78,0.31438783960299,0.73,0.38707779232158507,1.02,0.18273014979369728,1.05,0.701400856357868,0.84,0.22255513297854151,0.6,0.16514103883909154,0.43,0.14344647501089175,0.42,0.14999670290020575,0.37,0.26946429231893154]
["5-Oxoproline",35.51,14.961727090575021,63.84,39.442033922011696,41.1,9.859817818357419,30.73,17.57313677031097,30.5,10.015688555876165,17.87,3.6527198384773865,16.03,0.980216346023763,13.62,6.383431919833972,11.73,2.347190369408312]
["Phenylalanine",19.64,3.188703617712481,9.84,5.00849518748069,11.11,4.002297298103999,5.92,1.3866644441846598,7.26,1.9686681188499038,5.85,0.3200479870753782,6.35,2.123579961740031,8.1,2.324704998395155,6.79,0.2999168527286772]
["Phosphoenolpyruvate",11.05,1.3977327647794984,9.92,4.386867771689494,9.87,4.469608711871772,7.12,2.3285172415440063,7.51,2.468478555389195,12.19,2.604097801500501,11.23,3.1308468157296923,9.32,2.272749720492186,7.78,1.604883950584893]
["3-Phosphoglycerate",3.46,1.007637874726801,3.91,3.1133685718854465,5.51,3.2433794318750393,4.97,3.5101946060751708,5.46,3.348386036612578,13.94,5.340479859331788,12.79,5.091105811227176,10.07,3.431932981606148,6.84,4.333433842267527]
["Proline",210.18,70.18951796869011,158.02,92.31653844391548,344.37,37.60165963031859,285.52,121.08788199250984,585.01,424.91587682899103,332.55,36.754984872508096,261.12,87.04989579833422,282.89,254.86068816083912,263.2,103.64767083702723]
["Pyruvate",3.73,0.331128007783402,3.95,0.8129419115996296,3.73,0.9425059394560625,2.43,0.1018807353482887,1.51,0.4527628469677132,1.07,0.10769858559844331,0.9,0.23260773554406272,1.33,0.4396026616256407,1.29,0.5114638281634006]
["Serine",103.24,10.053781256728982,102.8,58.40431528246727,123.81,14.82084740140539,67.4,48.405745834213455,58.72,19.873252915108313,26.39,7.567078110736213,13.42,4.794560762373028,30.58,16.831871477543224,21.47,3.722980414107185]
["Succinate",2.62,0.49247989142359255,2.31,0.8106061447779774,2.5,0.2376840979038054,1.75,0.918544213139746,4.63,1.9548832573424701,3.16,0.4647539041625072,2.13,0.7938361597033876,1.5,0.6211148988054443,1.07,0.114349010002402]
["Threonine",31.02,4.886824137726032,26.53,13.543749432516453,32.18,3.227626606484448,25.74,15.444197682832423,52,30.237048483624232,41.5,7.767684550917979,11.33,10.189201383650198,0.6,0.37310717011708994,0.35,0.0752467318613811]
["Thymine",0.2,0.04980277701176846,0.12,0.06327545409637113,0.12,0.01822273723471579,0.11,0.03835915192759021,0.22,0.2535240530128893,0.12,0.025817004027015374,0.14,0.0710992102534415,0.21,0.1878598103086708,0.19,0.021549310672619025]
["Tryptophan",17.33,8.22704011481338,5.03,4.315005131646229,6.77,2.0908832465909075,2.94,1.239529809562196,5.13,1.2611223600563972,5.42,1.098877067466246,6.46,2.9982447681124653,13.25,6.652048311848869,10.71,4.800380486868688]
["UDP",0.47,0.5775937489872167,0.7,0.6163812789778359,0.48,0.26122190183592425,0.71,0.5306358159419029,0.64,0.4418465435102557,0.41,0.18145789321900568,0.19,0.13690083430376054,0.45,0.27363826013890546,0.47,0.17104626946035487]
["UMP",2.88,0.9404629724415402,2.41,0.8651265437558433,1.59,0.37705293698213915,1.52,0.829764374258376,1.26,0.40576578754101233,0.65,0.4099125803912584,0.63,0.04863559219678548,1.22,0.7259023485666987,1.14,0.29993916100760687]
["Uracil",0.16,0.0705998427821292,0.09,0.03406255976719616,0.09,0.033427999230974725,0.06,0.03441680001995656,0.12,0.06640558366260454,0.08,0.03764310251501147,0.08,0.042387764473876155,0.12,0.07311850956121872,0.13,0.021231355590822558]
["Urea",93.1,27.915740397015274,66.58,18.038726245614203,34.17,9.478313310981976,16.73,15.115513778657885,16.3,3.1140031180629424,13.49,4.178508530271461,14.63,4.548435767294549,18.6,5.924152276783507,11.83,6.42749008843688]
["UTP",5.8,0.6052471226289892,5.56,1.9664585868248514,5.35,0.05665462532834311,3.73,1.2258384294606108,2.78,1.1994685458175556,1.38,0.373189001898118,1.13,0.5141956764910306,1.23,0.23483056213372278,1.24,0.2838302668353171]
["Valine",65.97,7.48119518465814,47.26,18.508268172301907,63.01,7.098995920292936,51,33.45520627400737,98.47,50.901672938906316,48.49,18.897076993839608,50.73,20.36804355792701,65.03,46.516928826722676,49.15,9.680106089064886]

{"sheet":"Tab. S3","index":5,"n_rows":107,"n_cols":19,"rows_kept":107,"cut":false,"hidden":false,"merged":[[5,9,6,12],[5,13,6,18],[8,0,8,1],[18,0,18,1],[5,0,7,0],[5,1,7,1],[5,2,7,2],[5,3,6,8],[54,0,54,1],[67,0,67,1],[79,0,79,1],[27,0,27,1],[38,0,38,1],[42,0,42,1],[48,0,48,1]],"flags":["formulas_cached_only"]}
["Table S3:"]
["Selected fold changes in abundance of identified proteins. Given are the the ratios of the relative spot volumes and the respective standard deviations (SD). Reference value is the relative spot intensity at time point t0 (at optical density = 0.5). "]
["Ratios are average values of three independent experiments (proteins with available data from two experiments are labeled with *), proteins with significant changes (ANOVA) are marked with an “x”."]
[]
[]
["Protein name","Function","significantly changed expression (ANOVA)","exponential phase",{"$nulls":5},"transient phase",null,null,null,"stationary phase"]
[]
[null,null,null," t1/t0","SD","t3/t0","SD","t5/t0","SD","t7/t0","SD","t9/t0","SD","t13/t0","SD","t19/t0","SD","t24/t0","SD"]
["Glycolysis"]
["Pgi","glucose-6-phosphate isomerase",null,0.80951,0.08400606109085387,0.8452799999999999,0.1826716844505459,0.7754066666666667,0.07564413416341764,0.7294266666666666,0.06549331594394443,0.7253,0.04662424154879193,0.6748799999999999,0.03130195521049944,0.7945866666666667,0.1829179893649976,0.8070666666666666,0.18267425552970917]
["PfkA","6-phosphofructokinase",null,1.1769684734311987,0.25247736054561876,1.419122982925673,0.7062807532860688,1.4459745320743558,0.9707015444385495,1.332999116729653,0.8329790727017714,1.3264776626166654,0.7347422841320916,1.156969230034757,0.6231901243478557,1.309466579318289,0.7179977975943357,1.0065409377225851,0.41765001020228565]
["FbaA","fructose-bisphosphate aldolase, class II",null,1.3072615089550108,0.12063443393856123,2.033985419597565,1.2223402592012662,2.8098196993304385,2.63708936049327,2.6354954205019108,2.5878379115067793,2.6040365527149913,2.5246790325648254,2.4084515024642354,2.2000694822828395,2.277054945996029,2.074936380805031,2.482077202200863,2.683951559464153]
["TpiA","triosephosphate isomerase","x",1.0303733333333334,0.2504710235403153,0.7583866666666665,0.13594538253774455,0.6891366666666666,0.18548163637765708,0.7523733333333333,0.07377970610766475,0.66314,0.04876659512412235,0.6467166666666667,0.07103278773449177,0.6749366666666666,0.11174139534359427,0.79361,0.13481547500194466]
["GapA1","glyceraldehyde 3-phosphate dehydrogenase","x",0.9676538714288544,0.15871022812405186,0.7429120827230365,0.09201166171833924,0.7341380250078773,0.07022442242292264,0.6922623537970715,0.0669656301196836,0.6086647206131566,0.10565857237739402,0.6414419641468513,0.053066519335134066,0.6494622117993077,0.1316174029911153,0.666033723274183,0.09700075865086888]
["Pgk","phosphoglycerate kinase","x",0.9671995827567551,0.17124177292649806,0.8176949787553823,0.06802318847395525,0.860331287462467,0.16976735876730406,0.750264445891435,0.018731975910065864,0.7594097007692664,0.04644798657471127,0.6952566397478757,0.04895961192347731,0.7664334889192316,0.01240468073760424,0.8222129875763827,0.0395240807292362]
["Pgm","phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent","x",0.9076899158815305,0.12023053581034622,0.8299908506895095,0.2434360459395918,0.6174482089668204,0.17263145904971122,0.6559275782005818,0.1267079774060464,0.5825003691599122,0.1376957979455483,0.6196788985940974,0.11882057816855071,0.6279522520113462,0.17371830186794157,0.6754864430320097,0.14864839836186644]
["Eno","enolase",null,0.8978725754502821,0.13080863507491242,0.7192838223635989,0.09811388984377185,0.8053398476405998,0.1572020745814627,0.7541095439180774,0.11179548272412854,0.7121524474996975,0.1656862070947561,0.6785816079929976,0.1543479194992693,0.7184914832447357,0.07344219727308934,0.7687104276168314,0.19421005253732238]
["Pyk","pyruvate kinase",null,0.8633368917370143,0.116110684818755,1.5884895905724052,0.26312149807723856,1.588135790039292,0.7451675824029441,1.574006961929588,0.45613733397050465,1.6239125201540443,0.346421627491729,1.5578671360235365,0.6008812249013483,1.7155051727920394,0.31771898304006746,1.560757619762569,0.3251887380501757]
["Pyruvate metabolism"]
["PdhA","pyruvate dehydrogenase complex E1 component, alpha subunit",null,0.91582148901546,0.13282414564564418,0.8040216140575493,0.019527843496183427,1.0948517487283655,0.0847566365004073,0.9616249850089383,0.09028174058154109,0.9799810415415294,0.0836611773362662,0.887116653022438,0.07456918130552577,0.9346414757137139,0.19333932913244523,0.9858818566507628,0.05271178166063269]
["PdhB","pyruvate dehydrogenase complex E1 component, beta subunit",null,0.8971766666666667,0.15342167132883458,0.8012799999999999,0.15145725832722642,0.8782166666666668,0.05730401760202487,0.83197,0.06580236089989373,0.8180266666666668,0.14302257350968423,0.8056333333333333,0.0884627658019647,0.8821066666666666,0.13358732325087336,0.9669366666666667,0.06808883706844694]
["PdhC","pyruvate dehydrogenase complex E2 component, dihydrolipoamide acetyltransferase",null,0.9356849119246652,0.16599806300248332,0.9926236590585087,0.19143004897252405,1.1435744939693286,0.302997179193019,1.1050836804741437,0.09484095850648669,1.0156356086602036,0.10099171529031124,0.9860057434271843,0.0430811035122079,0.9893033113858977,0.20218703758434647,0.9852201449830363,0.12187667181707586]
["PdhD","pyruvate dehydrogenase complex E3 component, lipoamide dehydrogenase",null,0.9139182392193416,0.13699390411888984,0.911139654023082,0.18514639463443489,1.036906293125156,0.23728165686377525,1.0088890350809,0.1739621701082733,0.9883896622865932,0.0998960414980264,0.9866753976390591,0.26352222547587373,1.150189249104648,0.18485892945072813,1.177299756424394,0.1413955177210063]
["Pta","phosphate acetyltransferase","x",0.9153133333333333,0.15877432580027956,0.7616133333333334,0.07243755402643906,0.9109866666666667,0.13058148771297245,0.7013166666666667,0.026021624340792648,0.81205,0.158476474279307,0.6980566666666667,0.10604503115815125,0.7063,0.02816413854531914,0.8157733333333334,0.17695222556761855]
["Acs *","acetyl-CoA synthetase",null,3.32318,4.5449571203477825,4.068004999999999,5.1925750080331055,1.442455,1.9121228023456023,1.46864,1.7617989717331546,3.361125,4.022878970594317,3.01893,3.823849624893741,3.3394899999999996,4.269779445381225,3.1675649999999997,4.100137457506761]
["AckA","acetate kinase",null,1.2297887102201477,0.31204549220053424,1.7704103053551232,0.42009793628078584,1.7588689203718149,1.1870245851206118,1.7832751920091916,0.9362996221655097,1.835694003106185,0.8012143180725785,1.9073843477814887,0.8470245515526715,2.053743396715449,0.766195180432318,1.7388486488455641,0.7299734331350859]
["SACOL1749","NADP-dependent malic enzyme, putative",null,1.0014533333333333,0.20834247222622046,0.9796433333333333,0.246684366009144,1.0064133333333334,0.20793055387155884,0.9466633333333334,0.11295545685505091,0.98155,0.2803499101123453,0.9003166666666668,0.1424671121112983,0.9505533333333333,0.21324742772969907,1.1767933333333331,0.21765233155960811]
["Tricarboxylic acid cycle"]
["Acn","aconitate hydratase","x",1.08127071501404,0.29671424078340003,1.0997879288437105,0.44274922968417535,1.2115687516275275,0.14760010874001164,1.5963768734214945,0.21023128029739252,1.7671296777887588,0.014131806238437615,1.701054675984752,0.2843548190005731,1.76178103565658,0.5497998456596694,1.759465641520385,0.11905540116054006]
["Icd","isocitrate dehydrogenase, NADP-dependent","x",0.9661329157264157,0.09617706918021761,1.2476892902053456,0.3216087694255348,1.4600006811776387,0.5196789470584969,1.8364812517497164,0.6220078680125863,2.441117737298054,1.076384554518819,2.387966479545201,0.8748939703831139,3.174458775337266,1.2788836982138179,3.1610730748638947,1.1412128684997243]
["SucA","2-oxoglutarate dehydrogenase, E1 component",null,1.3087376103910706,0.7330033297877271,1.3093075341721292,0.5367552106480896,1.7027066635663684,0.6238707898679074,3.4591575139885102,1.0096051981504839,6.850664419834686,6.953318365531961,4.237063015564163,3.6208337411666935,6.87675435823495,6.69186975092207,7.0993557310345095,4.7089100212487685]
["SucB","2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase","x",0.8469266666666666,0.42732286158516425,2.34531,1.1348297743274085,2.4286033333333332,0.6505562629268382,4.134823333333334,1.684520002087635,5.247326666666667,2.512209570006715,5.6979033333333335,1.2188648427669588,7.523583333333334,3.594976642237514,6.292856666666666,2.8142811185511167]
["SucC *","succinyl-CoA synthase, beta subunit ",null,1.236305,0.032562267273640616,0.8074,0.332255334343935,1.209905,0.23991425978878395,0.8365400000000001,0.1371645734145659,1.073955,0.22787930237298806,0.990335,0.18675397197917928,0.7239450000000001,0.15076223681678375,0.861585,0.3540130100010448]
["SucD *","succinyl-CoA synthase, alpha subunit","x",1.409546501540356,0.41930791007858725,1.4793364620830902,0.42460381704620415,1.434764132737023,0.08298428299101761,1.6555621317030307,0.25865488578256907,1.8881402244943735,0.2933983633613344,1.878632964995396,0.05834987609850714,2.3692045711526135,0.05501237818469373,2.5859242503268094,0.0826349810474928]
["SdhA","succinate dehydrogenase, flavoprotein subunit","x",0.9054966666666666,0.32381127317209546,0.9947633333333333,0.16851888984126728,1.3034033333333335,0.5716847191707445,2.3396333333333335,1.1332712806884913,2.450156666666667,0.8000450803756832,2.833906666666666,1.0067604869249365,3.3006266666666666,1.146368835075925,3.1842666666666672,0.8492236545417998]
["FumC","fumarate hydratase, class II",null,1.1299166666666667,0.42194974064849583,1.3611666666666666,0.821900803158954,1.2741333333333333,1.188651027776165,1.0831066666666667,0.9458064559587934,1.7980666666666665,1.4826017075847895,2.2074266666666666,1.7295744092791536,2.4524233333333334,1.4900184419104792,2.40704,2.105433845576725]
["Mqo1","malate:quinone oxidoreductase",null,1.1993533333333335,0.45804722478510135,1.6077066666666668,0.9128627556392762,2.3926933333333333,0.8852215483896282,3.21073,1.6250992480153337,2.88334,1.7214430995243493,2.37051,0.3174538519218216,2.1678866666666665,0.44586928144169385,2.3544433333333337,0.19102214173579918]
["Mqo2","malate:quinone oxidoreductase",null,1.0165935323879867,0.3337055815325164,1.207589016813391,0.7197940523966859,1.761903640755279,1.110480639587694,1.6768217612319674,0.9980592152029011,1.6951556039577114,1.530450931879991,1.707764793634797,1.041398925655898,1.7439801752796729,1.1596306568754502,1.3143847344969413,0.8559295629366915]
["Pentose phosphate pathway"]
["Zwf","glucose-6-phosphate 1-dehydrogenase",null,0.9592353088342884,0.2010816317782735,1.1336303136044943,0.5916538999585279,1.2889965697495298,0.6095889760433226,1.5160494271288005,0.7844450755237508,1.4300712266779438,0.6192867674684969,1.422379576419268,0.6069516206055765,1.6591649493593181,1.0470033617657806,1.6896621826785239,0.783143477984058]
["Tal","transaldolase",null,1.0541500000000001,0.24734350284573836,0.7613333333333333,0.035584963584827906,0.7043133333333333,0.04638935689717325,0.8648533333333334,0.23414447192563276,0.82753,0.20411840117931582,0.8985799999999999,0.1102559281852908,0.9815433333333333,0.11645229337944894,1.0801366666666665,0.18671556692823904]
["Tkt","transketolase",null,0.9250266666666667,0.06541167046738147,0.9061266666666666,0.16285312165670496,0.99499,0.2098443454086865,0.9181066666666666,0.008147296074976862,0.9394366666666666,0.028836734096172073,0.8983666666666666,0.01208177277279017,1.0045266666666668,0.16094387541417407,0.9500633333333334,0.05657796773774673]
["Gluconeogenesis"]
["FdaB *","fructose-bisphosphate aldolase, class I","x",1.4804801412585298,0.04042904416466051,0.9666440984098329,0.16136696776379525,1.0735137739848795,0.12035013671999156,1.0838507923702316,0.24933786298183996,0.9230877499828232,0.2169923224256487,1.2104834823148907,0.0130006972050293,0.834967381828852,0.000829485104086918,1.0912621585306792,0.167196314074973]
["GapA2","glyceraldehyde 3-phosphate dehydrogenase",null,1.69884,1.8695204091156639,0.8716966666666668,0.17443515538254592,1.0320433333333332,0.6041646505989354,3.497833333333334,3.2974182839053543,10.237936666666666,11.5522022223658,6.223733333333333,2.815077750406434,18.5539,18.35442987332486,13.248320000000001,13.705623648170846]
["Gpm","phosphoglycerate mutase","x",1.2957211965839586,0.3571076310335761,1.3233088041054544,0.516139011958043,1.1441193244829941,0.2416597055907138,1.830030583458828,0.8047123295262095,1.8327983031822874,0.5172880117403534,2.233587068615982,0.7795042533363404,2.8062102045617596,1.1284861185447679,2.9575581496370886,1.3318314785313439]
["PckA","phosphoenolpyruvate carboxykinase","x",0.97628,0.19975651203402658,1.3481633333333332,0.7414132842304176,1.6201800000000002,0.7039045916173577,2.1009366666666667,1.1217233295395674,3.204943333333333,1.3460773633165866,3.612996666666666,2.0031081868519576,5.348603333333333,2.959729863776984,5.1895999999999995,2.8239361173369346]
["Pyc","pyruvate carboxylase",null,1.7227682650559704,0.67137713934947,3.5978695406922725,2.4086567496812417,3.240816053396435,2.3359755827733273,3.9370348127002948,2.5632412808032417,4.101163728890847,2.376985683908395,4.045762838022699,3.518392364478048,4.359288229766715,3.3241013595243536,3.8138009063696976,2.7797375702494125]
["Stress response"]
["AhpC","alkyl hydroperoxide reductase, C subunit",null,1.0564326901534444,0.26681593142595594,0.7993712691253477,0.17679907935655906,0.767224307401657,0.09619629221706041,1.0459087124106652,0.29745633353013545,0.9731534571591203,0.21290468499065,1.1733826345214302,0.36368831170713667,1.257566095429774,0.326695773459886,1.5646966318948305,0.43259476629723487]
["KatA","catalase",null,0.8730360256245581,0.11486255515846217,0.8072852247777379,0.19409166911975245,0.7663640814274828,0.3990582078532993,1.0304105115876452,0.5825560460497455,0.9846068143201704,0.4532845913161811,1.1566629897025882,0.5338609618856741,1.2415927813987488,0.5794694032085276,1.2618895635301568,0.5666187034127502]
["SodA1","superoxide dismutase",null,1.000795,0.31230785204666234,0.776565,0.31189773011357474,0.92832,0.14470233170201474,0.8786400000000001,0.1058963115504963,0.833635,0.1135259937195006,0.839385,0.03222285601867046,0.91598,0.08492352442050285,0.888855,0.08740546922246864]
["SodA2","superoxide dismutase",null,1.0492233561001159,0.1975459525374078,0.8084207667911506,0.010646951010230008,0.9153199904376542,0.08259691831091778,0.8602978901463599,0.12819495052206423,0.8093502944265839,0.1247779935695256,0.8201810069827689,0.20267856287755626,0.8100521753751817,0.14076068419799626,0.9130374420058341,0.17821819801076513]
["TrxB","thioredoxin-disulfide reductase",null,1.0753899892709151,0.23304768603008372,1.0808290167849375,0.370786529390054,0.8668047240076454,0.2683385787558778,0.9983906134136511,0.3992030300591894,0.9198402172388253,0.34734483444083547,1.0256741979187336,0.16654688148886035,1.0584483310160813,0.3515202603066484,0.9614220471390839,0.5007309608786426]
["Purine metabolism"]
["PurA","adenylosuccinate synthetase",null,1.4138866666666665,0.9991884695258115,2.1003333333333334,2.219305892172896,1.4136166666666667,1.0868679193137192,0.8563333333333333,0.4575401221022406,0.8647566666666666,0.4123028438336723,1.2112,1.028854249298704,0.8933266666666667,0.5331926241362811,1.1604733333333332,0.9125461111271767]
["PurB","adenylosuccinate lyase",null,1.4491366666666667,1.2077309866163628,1.83367,1.8448385276766095,2.2479933333333335,2.955367544423761,1.7552733333333332,2.17671655778453,2.896996666666667,3.627042720679387,2.8793966666666666,3.430754973826218,2.013833333333334,2.462466138129281,1.8283133333333332,2.276140742843758]
["PurC","phosphoribosylaminoimidazole-succinocarboxamide synthase",null,2.93364,3.504301920083371,0.7530266666666666,0.4397114791921328,1.1808566666666667,0.7020667242031439,1.7879633333333331,1.9573363345458372,1.2171333333333334,1.2562227333691003,1.8384266666666669,2.000375164471238,1.270336666666667,1.3362662476592502,1.1395133333333332,1.4309485102313546]
["PurD","phosphoribosylamine-glycine ligase",null,0.9395133333333333,0.13364087785304798,1.0630166666666667,0.21085863850772976,1.1849533333333333,0.23766684294056126,1.2249766666666666,0.3765906733222867,1.0615500000000002,0.08402390195652307,0.8683566666666667,0.0949873888120587,1.1788466666666666,0.17270547076839687,1.0672533333333334,0.07393101266270445]
["PurE","phosphoribosylaminoimidazole carboxylase, catalytic subunit",null,2.713903333333333,2.794409769116429,2.6567899999999995,3.2750732730887107,1.0935866666666667,0.26150238513889856,1.7967733333333333,1.9447647717997496,1.9168566666666667,2.120965028479567,1.3612566666666666,1.5249088146618257,1.5965533333333333,2.1718061450399597,2.149273333333334,2.7620887581924904]
["PurF","amidophosphoribosyltransferase",null,1.1539829949460116,0.6098000903696481,1.2647559037034075,0.9378305976857896,1.7148774432293032,1.010879653430319,1.5243313166611447,0.9015935071895405,2.0160588823651966,1.7145673995662527,2.0684859509530056,0.9932976596703506,1.518889307510099,0.9806399637046034,2.725576046891137,3.1845654648330206]
["PurH","phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase",null,0.725687403896032,0.1542900355547641,1.2663632310423776,0.3599922057666177,1.1552564194194037,0.6904989591115491,1.2247679732418664,0.34547665444844045,1.059893941768218,0.5884681603428995,1.3861971879616732,0.39780528996102127,1.4781300187017,0.42487951576638594,1.324038762808607,0.2970333432274179]
["PurK","phosphoribosylaminoimidazole carboxylase, ATPase subunit",null,1.4065633333333334,0.6947294785982049,2.6373433333333334,1.2726274201561647,1.7889333333333333,1.4965268895122914,1.9015866666666668,1.3219515643673683,0.9483499999999999,0.49774604287728946,1.86851,1.2122277016715965,1.4031733333333332,0.4084513498977978,1.1600066666666666,0.7987079376927043]
["PurL","phosphoribosylformylglycinamidine synthase II",null,1.06701,0.38503586339456797,1.0136866666666666,0.406115161294593,0.8784366666666666,0.22435871374504956,1.00296,0.3777915557552868,1.1350766666666667,0.3198472532840225,1.0871033333333333,0.4110444521378844,0.8798566666666666,0.5414734690022526,0.7198866666666667,0.4835274009126406]
["PurM","phosphoribosylformylglycinamidine cyclo-ligase","x",1.213965,0.09016318566909705,1.008665,0.3980940467402146,1.009045,0.4206083266531941,0.624595,0.1180939035259643,0.637595,0.15219059251478048,0.51231,0.23157747083859412,0.450905,0.016595796154448263,0.48470499999999994,0.09071472895842257]
["PurN","phosphoribosylglycinamide formyltransferase",null,1.2834166666666667,0.17835161180469744,1.10963,0.07743726493104237,0.9157733333333334,0.29957972600517035,1.00912,0.2019133608754008,0.9876399999999999,0.12902949004006886,0.89986,0.03569614685088595,0.9887966666666665,0.3638443530320812,1.1086033333333334,0.3804652909705868]
["PurQ","phosphoribosylformylglycinamidine synthase I",null,1.1724733333333333,0.6549392955330542,1.1675566666666668,0.42395877209150074,0.9381499999999999,0.5055670507459915,0.7789866666666668,0.14841002167418818,0.6975733333333333,0.15994663151605748,0.6671866666666665,0.1812617801229305,0.46809666666666666,0.2209281653237842,0.6342366666666667,0.08229924807270933]
["Cell wall metabolism"]
["Cap5G","UDP-N-acetylglucosamine 2-epimerase",null,1.66977,0.35158494691894904,2.02409,0.38565265317380937,1.93232,0.9355807229737038,2.26586,1.072403133294565,2.398433333333333,1.2886617517926628,2.6332733333333334,1.4271516865888274,2.439486666666667,0.763858425975216,1.8208933333333335,0.627540104402366]
["Cap5P","UDP-N-acetylglucosamine 2-epimerase",null,1.1670966666666667,0.8165907573768724,1.4381333333333333,0.3780188183587336,1.4261,1.0824672310513608,1.9332833333333335,1.2023917177997088,1.1090233333333332,0.29078113183859355,2.3624566666666666,1.6070288741131364,1.3200066666666668,0.5840671866603472,1.7665733333333333,1.735501562238805]
["FemC","glutamine synthetase",null,0.9379035726259071,0.11785969768377058,0.8842666067741849,0.27307459384127025,0.8453044596618371,0.20230067664314344,0.6890926104122851,0.21923825343737757,0.72811201036582,0.27588710415143675,0.7732233422011094,0.25131215383547484,0.7549976802149523,0.25349707823137996,0.7467250563792457,0.1997483041456511]
["GlmS","glucosamine-fructose-6-phosphate aminotransferase (isomerizing)",null,1.031137052273552,0.24713046597823773,1.529579859899784,0.5951903848109356,1.625534342055604,0.6602330513713882,1.7948417468292401,0.579066603196984,1.6925378756808211,0.5394963517159596,1.9350170131234037,0.5136040934180466,2.0349163252780174,0.7188749821577992,1.788755326100479,0.29267859369675214]
["GlmM *","phosphoglucosamine mutase",null,0.783845,0.01157533800802378,0.68804,0.004044650788387015,1.038785,0.5932979447545729,1.0099200000000002,0.3644711192947935,1.17745,0.6873502177201952,0.723885,0.1442992808367386,0.803455,0.037455446199453866,1.215695,0.731777736782146]
["MurAA","UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1",null,0.8588733333333334,0.11888513377766449,0.9283033333333334,0.45384045790710803,0.8691333333333334,0.42892525518245417,0.9312999999999999,0.16415035820856486,0.6299166666666666,0.09968061713960939,0.8448466666666666,0.2643826765000563,0.74033,0.14278631902251726,0.5635033333333334,0.18332267544778327]
["MurAB *","UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2",null,0.9887575148179508,0.2283848627657898,1.293729085520745,0.3162592856845313,1.5421891574936493,1.0006963252512946,1.1414229014959074,0.1847852473945319,1.3879805659046005,0.11320699535800516,1.4308362164832062,0.48200105776285884,1.1254479254868754,0.08124363535374025,1.1799986042901496,0.26195280432656937]
["MurC *","UDP-N-acetylmuramate-alanine ligase",null,1.1073310520553337,0.625912320336898,1.8018680594247665,1.010761775239015,2.1776996657527876,1.1480462705877537,1.3859722184955034,0.9503397147204947,1.5654201187043226,0.30480864840015864,1.6442281456882215,1.2432192572226861,1.2119642140297546,0.8151206364009458,1.57120183785985,1.4054776720064206]
["MurD","UDP-N-acetylmuramoylalanine-D-glutamate ligase","x",2.5437666666666665,1.5151158200062913,3.569616666666667,1.9309624344697462,4.5079400000000005,1.6153661600083122,3.3176699999999997,2.7855135292617055,5.7401366666666656,1.1915460675246046,2.41174,0.3738964210847688,1.868153333333333,0.42672904310971715,3.5391266666666668,1.0809015306369636]
["MurE *","UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase",null,0.89313,0.050091444379255834,1.4471,0.4134311928241508,1.19662,0.48462270355401177,1.26685,0.01552806491485657,1.18715,0.22570848455474632,1.07387,0.16295982879225038,1.259375,0.05067834300764487,1.187745,0.5449884094639079]
["SACOL2074","D-alanine-D-alanine ligase",null,1.0380766666666668,0.22910975979502363,0.8589966666666667,0.11419883551653788,0.9497466666666666,0.22380746465060858,0.9521033333333332,0.18440746523211526,0.9479466666666667,0.26845812156336957,0.9321400000000001,0.17466765041071483,1.0455866666666667,0.4541997904373506,0.9481933333333332,0.2562628576936847]
["Amino acid metabolism"]
["IlvB","acetolactate synthase, large subunit, biosynthetic type","x",0.8627699999999999,0.15727758517983376,0.9652133333333334,0.23628444602498286,1.0152433333333333,0.24644713516966157,1.00605,0.15091246104944273,0.95182,0.1730957997757313,0.8270233333333333,0.12980630043774222,0.59774,0.19044858518770852,0.51162,0.16976473956626004]
["IlvA2","threonine dehydratase",null,1.1878552229890813,0.08544357327558576,1.6528665112700989,0.371074972956777,1.5969046183652236,0.6927851848392448,1.550354871205389,0.7031936847816828,1.481927088634519,0.7318847324781689,1.191094245971759,0.5828772780831991,1.2527732092972446,0.7883163988652354,0.9486312855576818,0.49359236786839783]
["IlvC","ketol-acid reductoisomerase",null,0.9114676467098543,0.18293404617049416,0.9750998007740268,0.22604113367993797,1.0956170700281223,0.157122022720235,1.1186843394128851,0.05392794261259237,1.136848354437757,0.15899080588580145,1.0211178030958665,0.2027642301150104,0.8966877698844001,0.024801314847164222,0.7099581460855867,0.07071972873569013]
["IlvD","dihydroxy-acid dehydratase",null,0.846741607642818,0.10673117192539394,0.7498056576970203,0.07368619678596372,0.8417304202111767,0.12977318751918274,0.6965043449064892,0.08474106275159794,0.6644974770796215,0.09060025454845774,0.590825467933506,0.14126351499687204,0.5111003056581983,0.04666254143768488,0.494206670355267,0.030614537938754398]
["IlvE","branched-chain amino acid aminotransferase",null,1.1051,0.4778204379262155,1.7759366666666667,1.3844409507571394,1.44543,0.8058421415513093,1.38408,0.6630100579176763,1.1329266666666666,0.34957665916553077,1.1468366666666665,0.47713310850677076,1.0734266666666665,0.3042786330542021,1.12232,0.479516466557719]
["LeuA","2-isopropylmalate synthase",null,0.9888921092399275,0.16880290173904172,1.3239718970118421,0.13716452904057538,1.3506123424605085,0.5623082855670842,1.1861656669098983,0.31150901652639074,1.252033364093408,0.40547679566269884,1.1738575485145104,0.11261575846880865,1.1948382736419811,0.13981802806453955,0.8684924309657406,0.26004155985051264]
["LeuC","3-isopropylmalate dehydratase, large subunit ",null,1.3450499999999999,0.326492863781125,1.7419933333333333,0.19642139632263356,1.5282466666666668,0.8414691035524318,0.8741099999999999,0.018758264845128953,0.9152266666666667,0.30507995121497766,1.767966666666667,0.6956097235040155,1.12499,0.5482536519714208,1.0188366666666668,0.5492676779433986]
["LeuD","3-isopropylmalate dehydratase, small subunit","x",1.3470566666666663,0.38574535750068845,1.6104366666666667,0.5864618095267011,1.3389266666666666,0.35832030033663115,1.4542599999999999,0.29291765924914837,1.1703499999999998,0.16694067898508178,0.8740466666666666,0.18543152815347663,0.48094333333333344,0.0854566564600629,0.5053133333333334,0.08986841566052729]
["LeuB *","3-isopropylmalate dehydrogenase",null,1.0459450000000001,0.6542222650216055,1.839435,0.5571647882359414,1.63938,1.305276691663495,1.482035,1.0698454888674347,1.324205,0.9004934147732557,1.13599,0.6107139847751973,1.15643,0.6225933786991309,1.023605,0.7432328666373679]
["Dat","D-alanine aminotransferase",null,0.9981333333333334,0.2459315566033222,0.8066866666666668,0.135115114007771,0.88088,0.15330456842507983,0.8425699999999999,0.06827926259121472,0.777,0.06244407818200111,0.80384,0.07197508527261468,0.77313,0.037581752220991436,0.8176466666666666,0.10677788082432324]
["AroB","3-dehydroquinate synthase",null,0.8121499999999999,0.1642963179745673,0.9734766666666665,0.3821668761592689,1.07147,0.26754501079257625,1.2881033333333332,0.43923207149903476,1.1592833333333334,0.4586143493539354,1.2713,0.15971196667751517,1.2647033333333333,0.4807267624475816,1.08209,0.7225900377807598]
["AroC","chorismate synthase",null,1.5812866666666665,1.1412331410072765,1.9465266666666665,1.2112823082309645,2.4715866666666666,2.5171392076389685,2.3925899999999998,2.5920753910525054,2.434023333333333,2.8252060292540317,2.8397566666666667,3.6777600406950604,3.0095933333333336,3.3993459356519358,2.6826133333333337,3.2909571644938396]
["HisC *","histidinol-phosphate aminotransferase",null,1.7889199999999998,1.13873890255844,3.1453949999999997,0.9853179442443959,2.67721,2.1932048189350666,2.62317,1.669917516585775,2.24246,0.436214173313982,2.3482849999999997,1.423582727223817,2.102895,0.5832428863260989,2.4770700000000003,1.362410919583368]
["Asd *","aspartate-semialdehyde dehydrogenase",null,1.0076450000000001,0.15385936451838086,0.958115,0.2605052092569358,1.0104199999999999,0.3299501662372675,0.9015,0.3589415442659158,0.955945,0.38422061169333427,0.97061,0.30794500320674234,0.9803700000000001,0.5007871645719371,0.92963,0.4651065563932638]
["DapA","dihydrodipicolinate synthase",null,1.23031,0.23776988265968285,1.6836200000000001,0.8223983743296187,1.9165333333333334,0.7541255529640489,1.7532233333333334,0.40878425976709837,1.89979,0.8054604557022027,1.5564666666666669,0.2641149434116373,1.5245933333333335,0.6266021159662112,1.7765533333333332,0.44437669159546866]
["DapB","dihydrodipicolinate reductase",null,1.152757445769151,0.25334170274147133,0.995348462746802,0.25244280505629885,0.9285115486648804,0.16793315307194828,0.9891825088420081,0.10642410877349383,0.919451540105117,0.20039945470187717,0.9510986875119934,0.040395645273677123,0.8247737952224584,0.07422408505823751,0.9246776744949465,0.036558885544877476]
["DapD","2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase",null,1.0716366666666666,0.28181371264247196,0.9125166666666665,0.1825706025989227,0.8392866666666667,0.16086239471465433,0.8033100000000001,0.21096028441391493,0.84122,0.08859949209786723,0.7666366666666665,0.11246890785160799,0.7276333333333334,0.08371000318560076,0.8075566666666667,0.04244380559437736]
["SACOL1801","peptidase, M20/M25/M40 family",null,0.93636,0.1375483656754966,0.98551,0.14825620526642394,0.9136133333333333,0.20807423250689483,0.9527999999999999,0.19199728201201305,1.0794566666666665,0.19551036707380354,0.9461299999999998,0.1801497479876126,1.0572,0.2971775758700514,0.9043333333333333,0.12211406157086638]
["LysA","diaminopimelate decarboxylase",null,1.058248978586853,0.4304804944089947,1.512827751704025,0.8411784218416507,1.4793725762407932,0.8493924442593045,1.4000632263177908,0.8223964286041461,1.4846143074314597,0.7392320350885343,1.352770825933268,0.8121181630201008,1.2645287213544925,0.6666177712987672,1.2979445206726459,0.6901013162296545]
["Hom","homoserine dehydrogenase",null,1.0719666666666667,0.3501811980008824,1.1380333333333332,0.25912755166777107,1.3413933333333334,0.7034534314603439,1.07515,0.3294460625049261,1.0556233333333334,0.15219461893685224,1.3581966666666665,0.24589076443277408,1.0767166666666668,0.3821692454048778,1.12368,0.5989013266807819]
["ThrC","threonine synthase",null,1.0570493182754925,0.10278487246915008,1.1078612235869534,0.17652562241152356,1.1350168941829473,0.22151627229715823,1.127239276783997,0.021734189929648418,1.1539100835325475,0.03194976800883661,1.06736936828511,0.2595542824750597,1.0394330887808094,0.12483867984288972,0.8712190761959717,0.16634479363948773]
["GluD","glutamate dehydrogenase, NAD-specific",null,1.3009666666666666,0.4373575252963348,2.28445,0.5150782757018599,1.9079233333333334,0.7979797943139499,2.3832299999999997,0.9807613746982504,3.0532300000000006,0.45162932632856767,2.76988,2.033458198709775,3.36396,1.6486299841686742,3.4839599999999997,1.4570373391234703]
["GltD *","glutamate synthase, small subunit",null,0.8124100000000001,0.10262947822141409,1.080865,0.06948738338720241,0.894285,0.23990011765315997,0.9716799999999999,0.1756311823111147,0.999445,0.20144765089223554,1.024015,0.10453159546280982,1.1005150000000001,0.16008190419282123,0.6444799999999999,0.15949500556443805]
["SerA","D-3-phosphoglycerate dehydrogenase","x",1.0973431439144876,0.1479623418147585,2.168523360970033,0.6268370283406048,2.0905911161274804,0.6492108411992668,2.3956283236311386,0.07911776793389756,2.501278704650962,0.2534173746584027,2.1018789868862644,0.19374909212871316,2.2091457279840543,0.6915051436513748,1.9097255513167095,0.3760721019903188]
["GlyA","serine hydroxymethyltransferase ",null,0.840403630045015,0.052851632700232895,0.70782516743932,0.17536161759900729,0.8283121417544169,0.21133053364234938,0.7640244701857228,0.0966510190546748,0.6984774956713524,0.031170927877178848,0.7247226430884837,0.08227224502814291,0.6552545189531832,0.1334428371151963,0.6676528735601092,0.13092502175719534]
["CysK","cysteine synthase ","x",1.1936943226072794,0.25558648034837067,1.360597193935331,0.2178156061690594,1.4375531050439072,0.5296333130996316,1.4746842410751675,0.42191940118017396,1.8525758886936836,0.49678375007074754,1.8509399906678403,0.20794865057570205,2.185673583006793,0.6543022472891626,1.8136675527905133,0.3892267686135927]
["UreC","urease, alpha subunit","x",0.8023166666666667,0.08977973732047388,0.8728633333333334,0.09507461403199652,0.9303933333333333,0.08233100894154843,0.73942,0.07912228447157162,0.42724,0.05666955884776261,0.3100333333333333,0.053119313185821075,0.22441666666666663,0.09163987032582134,0.168,0.06230207299921886]

{"sheet":"Tab. S4","index":6,"n_rows":53,"n_cols":5,"rows_kept":53,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Table S4:"]
["In the manuscript used abbreviations and names of proteins A) and metabolites B)."]
[]
["A)",null,null,"B)"]
[]
["abbreviation","protein name",null,"abbreviation","metabolite name"]
["AckA","acetate kinase",null,"ADP","adenosine 5'-diphosphate"]
["Acn","aconitate hydratase",null,"AMP","adenosine 5'-monophosphate"]
["Acs","acetyl-CoA synthetase",null,"ATP","adenosine 5'-triphosphate"]
["ArcA","arginine deiminase",null,"CDP","cytidine 5'-diphosphate"]
["ArcB1","ornithine carbamoyltransferase",null,"CMP","cytidine 5'-monophosphate"]
["ArcB2","ornithine carbamoyltransferase",null,"CoA","coenzyme A"]
["ArcC","carbamate kinase",null,"CTP","cytidine 5'-triphosphate"]
["ArgB","acetylglutamate kinase",null,"dADP","2'-deoxyadenosine diphosphate"]
["ArgC","N-acetyl-gamma-glutamyl-phosphate reductase",null,"dAMP","2'-deoxyadenosine monophosphate"]
["ArgG","argininosuccinate synthase",null,"dATP","2'-deoxyadenosine triphosphate"]
["ArgH","argininosuccinate lyase",null,"dCDP","2'-deoxycytidine diphosphate"]
["ArgJ","glutamate N-acetyltransferase/amino-acid acetyltransferase",null,"dIMP","desoxyinosine 5'-monophosphate"]
["Eno","enolase",null,"dTDP","2'-deoxythymidine diphosphate"]
["FbaA","fructose-bisphosphate aldolase, class II",null,"dTTP","2'-deoxythymidine triphosphate"]
["FdaB","fructose-bisphosphate aldolase, class I",null,"FAD","flavin-adenine dinucleotide"]
["FumC","fumarate hydratase, class II",null,"FGAR","5'-P-ribosyl-N-formylglycinamide "]
["GapA1","glyceraldehyde 3-phosphate dehydrogenase",null,"FMN","riboflavine-5'-phosphate"]
["GapA2","glyceraldehyde 3-phosphate dehydrogenase",null,"GAR","5'-P-ribosylglycinamide "]
["Gpm","phosphoglycerate mutase",null,"GDP","guanosine 5'-diphosphate"]
["Icd","isocitrate dehydrogenase, NADP-dependent",null,"GMP","guanosine 5'-monophosphate"]
["Mqo1","malate:quinone oxidoreductase",null,"GTP","guanosine 5'-triphosphate"]
["Mqo2","malate:quinone oxidoreductase",null,"IDP","inosine 5'-diphosphate"]
["PckA","phosphoenolpyruvate carboxykinase",null,"IMP","inosine 5'-monophosphate"]
["PdhA","pyruvate dehydrogenase complex E1 component, alpha subunit",null,"NAD+","nicotinamide adenine dinucleotide"]
["PdhB","pyruvate dehydrogenase complex E1 component, beta subunit",null,"NADH","nicotinamide adenine dinucleotide (reduced)"]
["PdhC","pyruvate dehydrogenase complex E2 component, dihydrolipoamide acetyltransferase",null,"NADP+","dihydronicotinamide-adenine dinucleotide phosphate"]
["PdhD","pyruvate dehydrogenase complex E3 component, lipoamide dehydrogenase",null,"NADPH","dihydronicotinamide-adenine dinucleotide phosphate (reduced)"]
["PfkA","6-phosphofructokinase",null,"PEP","phosphoenolpyruvate"]
["Pgi","glucose-6-phosphate isomerase",null,"PRPP ","5'-phosphoribosyl 1'-pyrophosphate"]
["Pgk","phosphoglycerate kinase",null,"SA_1351.9663","remarkable metabolite of Staphylococcus aureus with mass [M-H+] 1351.9663"]
["Pgm","phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent",null,"SA_479.1138","remarkable metabolite of Staphylococcus aureus with mass [M-H+] 479.1138"]
["Pta","phosphate acetyltransferase",null,"SA_652.2098","remarkable metabolite of Staphylococcus aureus with mass [M-H+] 652.2098"]
["Pyc","pyruvate carboxylase",null,"SAICAR","5'-P-ribosyl-4-(N-succinocarboxamide)-5-aminoimidazole "]
["Pyk","pyruvate kinase",null,"UDP","uridine 5'-diphosphate"]
["RocD1","ornithine aminotransferase",null,"UDP-Gal","UDP-galactose"]
["RocF","arginase",null,"UDP-GalNAc","UDP-N-acetylgalactoseamine "]
["SACOL1749","NADP-dependent malic enzyme, putative",null,"UDP-Glc","UDP-glucose"]
["SdhA","succinate dehydrogenase, flavoprotein subunit",null,"UDP-GlcNAc","UDP-N-acetylglucoseamine "]
["SucA","2-oxoglutarate dehydrogenase, E1 component",null,"UDP-GlcNAcEP","UDP-N-acetylglucosamine enolpyruvate"]
["SucB","2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase",null,"UDP-ManNAcA","UDP-N-acetyl-D-mannosaminouronate"]
["SucC","succinyl-CoA synthase, beta subunit ",null,"UDP-MurNAc","UDP-N-acetylmuramate"]
["SucD","succinyl-CoA synthase, alpha subunit",null,"UDP-MurNAc-Ala","UDP-N-acetylmuramoyl-L-alanine"]
["Tal","transaldolase",null,"UDP-MurNAc-Ala-Glu","UDP-N-acetylmuramoyl-L-alanine-D-glutamate"]
["Tkt","transketolase",null,"UDP-MurNAc-Ala-Glu-Lys-Ala-Ala","UDP-N-acetylmuramoyl-L-alanine-D-glutamate-L-lysine-D-alanine-D-alanine"]
["TpiA","triosephosphate isomerase",null,"UMP","uridine 5'-monophosphate"]
["Zwf","glucose-6-phosphate 1-dehydrogenase",null,"UTP","uridine 5'-triphosphate"]
[null,null,null,"XMP","xanthosine 5'-monophosphate"]