File Name : Suppl Fig1.tif
Caption : Suppl. Fig. 1. Fluorescence lifetime images of APP and interacting partners. First column represents the FLIM images for HEK cell expressing APP-CFP. Blue color code is
corresponding to ~3.1ns. This value is almost same as CFP only expressing sample. Second column shows the CFP lifetime decreases for HEK cell co-expressing of APP interaction partners. Third column shows the fluorescence lifetime distribution for the whole FLIM images. According to the FLIM images, APP dimerization occurs on the membrane region, APP-APBB1 interaction is much stronger in the endosome.

File Name : Suppl Fig2.tif
Caption : Suppl. Fig. 2: Comparative plots of FRET lifetime against YFP/CFP fluorescence for APP-PSEN1 and APP-APPBP1.

File Name : Suppl table1.tif
Caption : Suppl. Table 1.
A list of BRET ratio between APP and interacting candidates

File Name : Suppl table2.tif
Caption : Suppl. Table 2. A list of fluorescence lifetimes of CFP when APP and interacting partners were coexpressed
in HEK-293 cell.

File Name : Suppl table3.tif
Caption : Suppl. Table 3. A list of FRET values between APP and interacting candidates measured by
cytometry based method.