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[null,"Table S4. Summary of the parameters in the final selected models."]
[]
[null,"Normal Model",{"$nulls":7},"MDS Model"]
[null,"Description","Symbol","Unit","Low-bound","Up-bound","Value ","Reference",null,"Description","Symbol","Unit","Low-bound","Up-bound","Value ","Reference"]
[null,"TNFα:TNFR1 association","a1","nM-1min-1","-","-",1.09986,"[1] ",null,"TNFα:TNFR1 association","a1","nM-1min-1","-","-",1.09986,"[1] "]
[null,"TNFα:TNFR1 dissociation","d1","min-1 ","-","-",0.12,"[1] ",null,"TNFα:TNFR1 dissociation","d1","min-1 ","-","-",0.12,"[1] "]
[null,"TNFα:TNFR1:TRAF2 association","a2","nM-1min-1 ","-","-",0.0111,"[1] ",null,"TNFα:TNFR1:TRAF2 association","a2","nM-1min-1 ","-","-",0.0111,"[1] "]
[null,"TNFα:TNFR1:TRAF2 dissociation","d2","min-1 ","-","-",0.075,"[1] ",null,"TNFα:TNFR1:TRAF2 dissociation","d2","min-1 ","-","-",0.075,"[1] "]
[null,"ASK1 phosphorylation by TNFα:TNFR1:TRAF2 ","K1","nM-1min-1 ",0.0001,10,7.11206,"Estimated  ",null,"ASK1 phosphorylation by TNFα:TNFR1:TRAF2 ","K1","nM-1min-1 ",0.0001,10,1.38256,"Estimated  "]
[null,"pASK1 dephosphorylation by pp38","K2","nM-1min-1 ",0.0001,10,8.46513,"Estimated ",null,"pASK1 dephosphorylation by pp38","K2","nM-1min-1 ",0.0001,10,2.33656,"Estimated "]
[null,"pASK1 dephosphorylation by pAKT ","K3","nM-1min-1 ",0.0001,10,0.0011469,"Estimated ",null,"pASK1 dephosphorylation by pAKT ","K3","nM-1min-1 ",0.0001,10,0.98586,"Estimated "]
[null,"MKK3/6 phosphorylation by pASK1 ","K4","nM-1min-1 ",0.0001,10,8.93867,"Estimated ",null,"MKK3/6 phosphorylation by pASK1 ","K4","nM-1min-1 ",0.0001,10,0.99511,"Estimated "]
[null,"pMKK3/6 auto-dephosphorylation ","K5","min-1 ",0.0001,10,1.85452,"Estimated ",null,"pMKK3/6 auto-dephosphorylation ","K5","min-1 ",0.0001,10,1.66521,"Estimated "]
[null,"p38 phosphorylation by pMKK3/6","K6","nM-1min-1 ",0.0001,10,0.64591,"Estimated ",null,"p38 phosphorylation by pMKK3/6","K6","nM-1min-1 ",0.0001,10,0.85422,"Estimated "]
[null,"pp38 dephosphorylation by pJNK ","K7","nM-1min-1 ",0.0001,10,7.65542,"Estimated ",null,"pp38 dephosphorylation by pJNK ","K7","nM-1min-1 ",0.0001,10,2.01135,"Estimated "]
[null,"MEKK1 phosphorylation by TNFα:TNFR1:TRAF2 ","K8","nM-1min-1 ",0.0001,10,0.00053685,"Estimated ",null,"MEKK1 phosphorylation by TNFα:TNFR1:TRAF2 ","K8","nM-1min-1 ",0.0001,10,0.11847,"Estimated "]
[null,"pMEKK1 auto-dephosphorylation ","K9","min-1 ",0.0001,10,7.72227,"Estimated ",null,"pMEKK1 auto-dephosphorylation ","K9","min-1 ",0.0001,10,0.0055486,"Estimated "]
[null,"MKK4/7 phosphorylation by pASK1","K10","nM-1min-1 ",0.0001,10,0.15664,"Estimated ",null,"MKK4/7 phosphorylation by pMEKK1","K11","nM-1min-1 ",0.0001,10,0.20023,"Estimated "]
[null,"MKK4/7 phosphorylation by pMEKK1","K11","nM-1min-1 ",0.0001,10,0.00085426,"Estimated ",null,"JNK phosphorylation by pMKK4/7","K13","nM-1min-1 ",0.0001,10,1.22054,"Estimated "]
[null,"pMKK4/7 dephosphorylation by pAKT ","K12","nM-1min-1 ",0.0001,10,0.095424,"Estimated ",null,"pJNK dephosphorylation by pp38 ","K14","nM-1min-1 ",0.0001,10,0.00085424,"Estimated "]
[null,"JNK phosphorylation by pMKK4/7","K13","nM-1min-1 ",0.0001,10,0.55474,"Estimated ",null,"c_Jun phosphorylation by pJNK ","K16","nM-1min-1 ",0.0001,10,0.44709,"Estimated "]
[null,"pJNK dephosphorylation by pp38 ","K14","nM-1min-1 ",0.0001,10,0.18539,"Estimated ",null,"pc_Jun auto-dephosphorylation ","K17","min-1 ",0.0001,10,0.55409,"Estimated "]
[null,"c_Jun phosphorylation by pp38 ","K15","nM-1min-1 ",0.0001,10,0.88531,"Estimated ",null,"AKT auto-phosphorylation ","K18","min-1 ",0.0001,10,0.26575,"Estimated "]
[null,"pc_Jun auto-dephosphorylation ","K17","min-1 ",0.0001,10,5.24853,"Estimated ",null,"pAKT dephosphorylation by pp53","K19","nM-1min-1 ",0.0001,10,2.52025,"Estimated "]
[null,"AKT auto-phosphorylation ","K18","min-1 ",0.0001,10,0.34331,"Estimated ",null,"p53 phosphorylation by pp38","K20","nM-1min-1 ",0.0001,10,5.00153,"Estimated "]
[null,"pAKT dephosphorylation by pp53","K19","nM-1min-1 ",0.0001,10,5.99847,"Estimated ",null,"pp53 dephosphorylation by pAKT ","K22","nM-1min-1 ",0.0001,10,0.20075,"Estimated "]
[null,"p53 phosphorylation by pp38","K20","nM-1min-1 ",0.0001,10,0.0035486,"Estimated ",null,"BCL-XL phosphorylation by pp38","K23","nM-1min-1 ",0.0001,10,0.00058915,"Estimated "]
[null,"p53 phosphorylation by pJNK ","K21","nM-1min-1 ",0.0001,10,8.00158,"Estimated ",null,"pBCL-XL auto-dephosphorylation ","K25","min-1 ",0.0001,10,0.052175,"Estimated "]
[null,"pp53 dephosphorylation by pAKT ","K22","nM-1min-1 ",0.0001,10,0.00085549,"Estimated ",null,"pBCL-XL auto-degradation ","K26","min-1 ",0.0001,10,0.22165,"Estimated "]
[null,"BCL-XL phosphorylation by pJNK ","K24","nM-1min-1 ",0.0001,10,3.88645,"Estimated "]
[null,"pBCL-XL auto-dephosphorylation ","K25","min-1 ",0.0001,10,0.51105,"Estimated ",null,"Ref. [1]  Sung Gyoo Parkab, Taehyung Leec, Hee Yong Kanga, Kunsoo Parkc, Kwang-Hyun Chode, Guhung Jung. The influence of the signal dynamics of activated form of IKK on NF-κB and anti-apoptotic gene expressions: A systems biology approach. FEBS Letters, 2006, 580(3): 822-830."]
[null,"pBCL-XL auto-degradation ","K26","min-1 ",0.0001,10,0.14522,"Estimated "]

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