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["Table S1: List of studies employed in this work"]
[]
[null,"Subsets used","Organism","Duration","(end) age","Tissue(s)","Amount of food","PubMed ID"]
["GEO"]
["GDS1261; (Tsuchiya, 2004)","Ames dwarf and normal mice","Mus musculus","4 months","6 months","liver","90% of the AL intake* of animals of the same genotype for 1 wk, to 80% for the next week, and to 70% for the rest (*average amount consumed daily by AL mice during the preceding week); ",15039484]
["GDS1808; (Dhahbi, 2005)","CR8-AL and LTCR-AL; have CON in common","Mus musculus","CR8: 2month; LTCR: 17 months","22 months","liver","CON 93kcal/wk; LTCR: 52.2; CR8: 77 for 2 weeks, 52.2 for 6 weeks",16189280]
["GDS2612; (Edwards, 2007)","25 months old","Mus musculus","23.5 months","~25 months","skeletal muscle","CON 84kcal/wk, CR 26% less (62kcal/wk)",17381838]
["GDS2681; (Someya, 2007)","15 months old; excluded: 4 months: CR missing","Mus musculus","3 months","15 months","cochlea","CON 84kcal/wk, CR 26% less (62kcal/wk)",16890326]
["GDS2961 + GDS2962; (Lustig, 2007)","6, 16 and 24 months old; excluded: 1 months old: CR missing","Mus musculus","11, 41 and 83 weeks","6.5, 13.5, 24 months","thymus","Up to 13 weeks of age, 100% regular feed, followed by 90% fortified feed for 1 week, 75% for 1 week, then 60% fortified feed after that until the age at which the mice were sacrificed",17499630]
["GDS355 + GDS356; (Kayo, unpublished)",">30 months old; excluded: 5 months old; CR missing","Mus musculus","?","> 30 months","kidney","?"]
["GSE11244; (Estep, 2009)","FHC-CR, TAL-CR; have CR in common","Mus musculus","14 days","9.5 months","liver","true ad libitum: as much as wanted (about 125kcal/wk); CR: 73kcal/wk; fixed high cal: 110 kcal/wk",19370158]
["GSE11291; (Barger, 2008)","3 tissues; excluded: 5 months: CR missing","Mus musculus","16 months ","30 months","Heart, neocortex, gastrocnemius","CON: 84 kcal/week, CR: 63 kcal/week",18523577]
["GSE14202; (Padovani, 2009)","exercise and non-exercise","Mus musculus","6 weeks","4 months","mammary gland","30% restriction",19952363]
["GSE18297; (Saito, unpublished)","1 week or 1 month CR; 5, 10, 20, 30% food restriction; same controls for different restriction levels","Rattus norvegicus","one week or one month","1.5 or ~2 months","liver","5, 10, 20, 30% restriction"]
["GSE6110; (Chen, 2007)","24 months old; excluded: 4 months old: CR missing","Rattus norvegicus","22.5 months","25 months","kidney","CR begins at 10 wk, 10% restriction until 15 wk where it is increased to 25 and to 40% at 4 months",17670906]
["GSE6718; (Linford, 2007)","2 tissues; excluded: 4 months","Rattus norvegicus","20 months","24 months","Heart and Adipose Tissue","60% of AL",17874999]
["GSE7502; (Sharov, 2008)","2 tissues; ages: 6, 16, 24 months; excluded: 1 month:  CR missing","Mus musculus","2.5, 12.5, 20.5 months","6, 16, 24 months","Testis and Ovary","40% restriction",18522719]
["GSE8426; (Xu, 2007)","5 tissues; 6, 16, 24 months; excluded: ~1mo samples: CR missing","Mus musculus","2.5, 12.5, 20.5 months","6, 16, 24 months","Cerebellum, Hippocampus, Spinal Cord, Striatum, Cortex","at 14 weeks of age at 10% restriction, and then changed to 25% at 15 weeks and 40% restriction at 16 weeks onward",17988385]
["GSE17309; (Fernández, unpublished)","no subsets","Sus scrofa","211 days","~7 months ?","liver","25% restriction"]
["GSE241; (Massaro, 2004)","2, 4, 12h CR; excluded: other timepoints: miss controls","Mus musculus","2-96h; timepoints >12h miss controls; there is a 14/15d timepoint in the paper, but not in the file","adult","lung","reduction by 66%",14594731]
["GSE9121; (Pohjanvirta, 2008)","adipose tissue: 10 d CR; liver: 4 and 10 d CR (controls for timepoints pooled)","Rattus norvegicus","liver: 4 or 10 days; WAT: 4 days","~3-4 months","liver, adipose tissue","restricted: 4 day: 18–12–9–6 g; 10 day: ad libitum–16–14–11–8–6–4–4–2–1 g",18394668]
["GSE904; (Becker, unpublished)","~170 d old; excluded: 17d old: no CR","Mus musculus","?","?","liver","?"]
[]
["GAN"]
["Expression Profile of Aging and CR Retardation, Neocortex; (Lee, 2000)","30  months old, Neocortex; excluded: Hippocampus: CR missing, 5 months: CR missing","Mus musculus","28 months","30 months","neocortex","26% less than AL","11923192 and 10888876"]
[]
["Array Express"]
["E-MEXP-748; (Selman, 2006)","4 tissues","Mus musculus","16 days","~4 months","liver, skeletal muscle, colon, hypothalamus","reduced to 90% of AL mice at 14 wk, 80% at 15 wk, and 70% at 16 wk of age",16882887]
[]
["Provided by"]
["Hu; (Wu, 2008)","no subsets","Mus musculus","4 months","8 months","forebrain","70% less than AL"]