{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["Genes_list"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Genes_list","index":0,"n_rows":181,"n_cols":7,"rows_kept":181,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Table S2: List of genes consistently overexpressed (a,) and underexpressed (b,) with CR"]
[]
["a,"]
["MGI Symbol","MGI Description","EntrezID","total","overexp.","underexp.","p_overexp."]
["Mt2","metallothionein 2 Gene",17750,59,14,5,1.8534052806215998e-10]
["Adh1","alcohol dehydrogenase 1 (class I) Gene",11522,42,12,0,3.5034059823374097e-10]
["Per2","period homolog 2 (Drosophila) Gene",18627,44,12,1,6.37663652903671e-10]
["Por","P450 (cytochrome) oxidoreductase Gene",18984,61,13,0,3.4113439288425e-09]
["Inmt","indolethylamine N-methyltransferase Gene",21743,33,10,4,5.508951510627e-09]
["Dbp","D site albumin promoter binding protein Gene",13170,34,10,4,7.62675116542461e-09]
["Nat8","N-acetyltransferase 8 (GCN5-related, putative) Gene",68396,26,9,0,8.525486327506809e-09]
["Ehhadh","enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase Gene",74147,39,10,0,3.29589843061357e-08]
["Mt1","metallothionein 1 Gene",17748,61,12,2,3.5416501584751904e-08]
["Cyp2j6","cytochrome P450, family 2, subfamily j, polypeptide 6 Gene",13110,30,9,0,3.5636376483498804e-08]
["Abcg5","ATP-binding cassette, sub-family G (WHITE), member 5 Gene",27409,30,9,0,3.5636376483498804e-08]
["Fam107a","family with sequence similarity 107, member A Gene",268709,22,8,0,3.73041740682966e-08]
["Klf15","Kruppel-like factor 15 Gene",66277,32,9,0,6.675351487029651e-08]
["Sds","serine dehydratase Gene",231691,25,8,0,1.1793746529966899e-07]
["Fkbp5","FK506 binding protein 5 Gene",14229,59,11,1,2.3357721439242198e-07]
["Zbtb16","zinc finger and BTB domain containing 16 Gene",235320,19,7,0,2.45585154215017e-07]
["Angptl4","angiopoietin-like 4 Gene",57875,37,9,2,2.6423237639153295e-07]
["Usp2","ubiquitin specific peptidase 2 Gene",53376,60,11,0,2.7947568180778797e-07]
["Cobll1","Cobl-like 1 Gene",319876,28,8,0,3.1680595608166397e-07]
["Fmo3","flavin containing monooxygenase 3 Gene",14262,29,8,0,4.2777192333916296e-07]
["Cyp7a1","cytochrome P450, family 7, subfamily a, polypeptide 1 Gene",13122,39,9,2,4.3010080046028597e-07]
["Ablim3","actin binding LIM protein family, member 3 Gene",319713,21,7,1,5.421786648132099e-07]
["Nr1i3","nuclear receptor subfamily 1, group I, member 3 Gene",12355,40,9,0,5.42500417549641e-07]
["Cyp4a14","cytochrome P450, family 4, subfamily a, polypeptide 14 Gene",13119,32,8,0,9.79991943553517e-07]
["Sult1d1","sulfotransferase family 1D, member 1 Gene",53315,45,9,3,1.5694606517825899e-06]
["Herpud1","homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Gene",64209,45,9,2,1.5694606517825899e-06]
["LOC100047583","similar to apolipoprotein D",100047583,5,4,0,1.9597555663476e-06]
["Ctgf","connective tissue growth factor Gene",14219,35,8,0,2.05009087957907e-06]
["Slc37a4","solute carrier family 37 (glucose-6-phosphate transporter), member 4 Gene",14385,35,8,0,2.05009087957907e-06]
["Tenc1","tensin like C1 domain-containing phosphatase Gene",209039,60,10,0,2.41450182206486e-06]
["Wee1","WEE 1 homolog 1 (S. pombe) Gene",22390,37,8,2,3.21549696680629e-06]
["Klf9","Kruppel-like factor 9 Gene",16601,51,9,0,4.70288709837355e-06]
["Ppara","peroxisome proliferator activated receptor alpha Gene",19013,40,8,1,5.98876343555338e-06]
["Trp53i13","transformation related protein 53 inducible protein 13 Gene",216964,29,7,1,6.0978480069230696e-06]
["Irs2","insulin receptor substrate 2 Gene",384783,29,7,1,6.0978480069230696e-06]
["Fam195a","family with sequence similarity 195, member A Gene",68241,20,6,0,7.2340493669053895e-06]
["Acot4","acyl-CoA thioesterase 4 Gene",171282,30,7,0,7.78012493626696e-06]
["Ntf3","neurotrophin 3 Gene",18205,42,8,0,8.78892655983304e-06]
["Tmem218","transmembrane protein 218 Gene",66279,21,6,0,9.91079764774226e-06]
["Aldh1a1","aldehyde dehydrogenase family 1, subfamily A1 Gene",11668,56,9,2,1.04578721597483e-05]
["Gm6957","predicted gene 6957 Gene",629219,13,5,0,1.09326555009086e-05]
["Pim3","proviral integration site 3 Gene",223775,57,9,0,1.21409889397083e-05]
["Klf9","Kruppel-like factor 9 Gene",70273,14,5,0,1.66517173155449e-05]
["Aqp6","aquaporin 6 Gene",11831,23,6,2,1.76564094443482e-05]
["Cyp2b13","cytochrome P450, family 2, subfamily b, polypeptide 13 Gene",13089,23,6,1,1.76564094443482e-05]
["Decr2","2-4-dienoyl-Coenzyme A reductase 2, peroxisomal Gene",26378,24,6,0,2.30385016107653e-05]
["Cry1","cryptochrome 1 (photolyase-like) Gene",12952,49,8,0,2.8717982919798003e-05]
["Tsc22d3","TSC22 domain family, member 3 Gene",14605,26,6,0,3.77419488957767e-05]
["Cbr1","carbonyl reductase 1 Gene",12408,38,7,0,4.04380314868097e-05]
["Rgs16","regulator of G-protein signaling 16 Gene",19734,27,6,2,4.74893319507932e-05]
["Hacl1","2-hydroxyacyl-CoA lyase 1 Gene",56794,27,6,0,4.74893319507932e-05]
["Sult1c2","sulfotransferase family, cytosolic, 1C, member 2 Gene",69083,27,6,1,4.74893319507932e-05]
["Gys2","glycogen synthase 2 Gene",232493,27,6,0,4.74893319507932e-05]
["Cyp2e1","cytochrome P450, family 2, subfamily e, polypeptide 1 Gene",13106,39,7,0,4.82120828800596e-05]
["Plin5","perilipin 5 Gene",66968,17,5,1,4.83196930157717e-05]
["Cpt1a","carnitine palmitoyltransferase 1a, liver Gene",12894,53,8,1,5.16222667576721e-05]
["Igfbp2","insulin-like growth factor binding protein 2 Gene",16008,40,7,1,5.71685445804095e-05]
["Arrdc2","arrestin domain containing 2 Gene",70807,40,7,0,5.71685445804095e-05]
["4833417J20Rik","4833417J20Rik RIKEN cDNA 4833417J20 gene",74604,4,3,0,6.242150169891119e-05]
["4432414F05Rik","4432414F05Rik RIKEN cDNA 4432414F05 gene",77027,4,3,0,6.242150169891119e-05]
["Agxt2l1","alanine-glyoxylate aminotransferase 2-like 1 Gene",71760,18,5,0,6.551259947278019e-05]
["St3gal5","ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Gene",20454,41,7,1,6.744056670141289e-05]
["Slc25a25","solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Gene",227731,41,7,0,6.744056670141289e-05]
["Lpin1","lipin 1 Gene",14245,29,6,1,7.299118428742319e-05]
["Gpr146","G protein-coupled receptor 146 Gene",80290,31,6,0,0.00010836527594856701]
["Adcy1","adenylate cyclase 1 Gene",432530,11,4,0,0.000114537431581072]
["Ifrd1","interferon-related developmental regulator 1 Gene",15982,45,7,0,0.00012468797775435202]
["Mat1a","methionine adenosyltransferase I, alpha Gene",11720,60,8,0,0.00012751507686284102]
["Acot12","acyl-CoA thioesterase 12 Gene",74156,32,6,0,0.000130532313303271]
["Nfkbia","nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Gene",18035,61,8,0,0.00014353543553074702]
["Epb4.1","erythrocyte protein band 4.1 Gene",269587,61,8,1,0.00014353543553074702]
["Hsd17b2","hydroxysteroid (17-beta) dehydrogenase 2 Gene",15486,46,7,5,0.000143878829882948]
["Sun2","Sad1 and UNC84 domain containing 2 Gene",223697,34,6,1,0.000185569335617105]
["Mgp","matrix Gla protein Gene",17313,48,7,1,0.00018943597346062703]
["Aldh1a7","aldehyde dehydrogenase family 1, subfamily A7 Gene",26358,35,6,2,0.00021920080874647]
["Sult3a1","sulfotransferase family 3A, member 1 Gene",57430,23,5,1,0.00023166760754191702]
["Niacr1","niacin receptor 1 Gene",80885,13,4,0,0.00023834296976149802]
["BC089597","cDNA sequence BC089597 Gene",216454,13,4,0,0.00023834296976149802]
["Dusp1","dual specificity phosphatase 1 Gene",19252,36,6,0,0.000257450776993845]
["Klf10","Kruppel-like factor 10 Gene",21847,36,6,0,0.000257450776993845]
["Rhbdd2","rhomboid domain containing 2 Gene",215160,51,7,0,0.00027894225549215604]
["Sult1a1","sulfotransferase family 1A, phenol-preferring, member 1 Gene",20887,37,6,0,0.000300753009192091]
["Decr1","2,4-dienoyl CoA reductase 1, mitochondrial Gene",67460,37,6,0,0.000300753009192091]
["Cd163","CD163 antigen Gene",93671,14,4,1,0.000327019470739879]
["Plcxd3","phosphatidylinositol-specific phospholipase C, X domain containing 3 Gene",239318,14,4,0,0.000327019470739879]
["Bnip3","BCL2/adenovirus E1B interacting protein 3 Gene",100042570,14,4,0,0.000327019470739879]
["Fzd1","frizzled homolog 1 (Drosophila) Gene",14362,38,6,2,0.00034956206751183205]
["Per1","period homolog 1 (Drosophila) Gene",18626,38,6,1,0.00034956206751183205]
["Enpep","glutamyl aminopeptidase Gene",13809,25,5,0,0.000350796014187919]
["Sall1","sal-like 1 (Drosophila) Gene",58198,25,5,0,0.000350796014187919]
["Slc25a42","solute carrier family 25, member 42 Gene",73095,25,5,1,0.000350796014187919]
["Zfp354a","zinc finger protein 354A Gene",21408,54,7,0,0.00039961532339334604]
["Pla2g12a","phospholipase A2, group XIIA Gene",66350,39,6,1,0.000404352973808517]
["Map3k6","mitogen-activated protein kinase kinase kinase 6 Gene",53608,26,5,0,0.00042533269640033405]
["Rbp7","retinol binding protein 7, cellular Gene",63954,26,5,3,0.00042533269640033405]
["Rhobtb1","Rho-related BTB domain containing 1 Gene",69288,26,5,0,0.00042533269640033405]
["Crym","crystallin, mu Gene",12971,15,4,0,0.000437042170456501]
["Plin4","perilipin 4 Gene",57435,15,4,0,0.000437042170456501]
["LOC100044830","similar to acyl-CoA thioesterase",100044830,15,4,0,0.000437042170456501]
["Smoc1","SPARC related modular calcium binding 1 Gene",64075,55,7,0,0.000448001610230848]
["Tob1","transducer of ErbB-2.1 Gene",22057,40,6,0,0.00046562081426053604]
[]
["b,"]
["MGI Symbol","MGI Description","EntrezID","total","overexp.","underexp.","p_underexp."]
["Slc6a6","solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Gene",21366,60,1,12,7.660607911798301e-09]
["Car3","carbonic anhydrase 3 Gene",12350,49,0,11,8.86066645605647e-09]
["Cyp2j5","cytochrome P450, family 2, subfamily j, polypeptide 5 Gene",13109,25,0,8,4.6415692349833605e-08]
["Dhcr7","7-dehydrocholesterol reductase Gene",13360,49,0,10,1.107913471794e-07]
["Arntl","aryl hydrocarbon receptor nuclear translocator-like Gene",11865,63,3,11,1.4060713240906197e-07]
["Zfp64","zinc finger protein 64 Gene",22722,34,1,8,6.51566670449327e-07]
["Srebf1","sterol regulatory element binding transcription factor 1 Gene",20787,60,1,10,8.13254114871969e-07]
["Es31","esterase 31 Gene",382053,25,1,7,9.13918176683317e-07]
["Gck","glucokinase Gene",103988,41,1,8,2.9845372814191598e-06]
["Col15a1","collagen, type XV, alpha 1 Gene",12819,32,1,7,5.58151083719162e-06]
["G0s2","G0/G1 switch gene 2 Gene",14373,33,3,7,6.9473897286295096e-06]
["Insig1","insulin induced gene 1 Gene",231070,33,1,7,6.9473897286295096e-06]
["C9","complement component 9 Gene",12279,36,1,7,1.28043348897288e-05]
["Phlda1","pleckstrin homology-like domain, family A, member 1 Gene",21664,39,1,7,2.22539254926098e-05]
["Hspa5","heat shock protein 5 Gene",14828,69,0,9,2.27428614726149e-05]
["Irgm1","immunity-related GTPase family M member 1 Gene",15944,28,0,6,3.00391350388836e-05]
["Dpp9","dipeptidylpeptidase 9 Gene",224897,28,0,6,3.00391350388836e-05]
["Alas2","aminolevulinic acid synthase 2, erythroid Gene",11656,58,3,8,4.27900487811104e-05]
["Tmem132d","transmembrane protein 132D Gene",243274,4,0,3,4.3369832213985697e-05]
["Irf7","interferon regulatory factor 7 Gene",54123,30,1,6,4.55718468327957e-05]
["Fabp5","fatty acid binding protein 5, epidermal Gene",16592,59,3,8,4.85362133827933e-05]
["Tnfsf10","tumor necrosis factor (ligand) superfamily, member 10 Gene",22035,19,0,5,4.8919145671018796e-05]
["Acly","ATP citrate lyase Gene",104112,60,2,8,5.49107871469965e-05]
["Scly","selenocysteine lyase Gene",50880,31,1,6,5.54419370565003e-05]
["C4bp","complement component 4 binding protein Gene",12269,20,0,5,6.402509275081301e-05]
["Ifi27l2a","interferon, alpha-inducible protein 27 like 2A Gene",76933,20,0,5,6.402509275081301e-05]
["Casc5","cancer susceptibility candidate 5 Gene",76464,11,1,4,7.14395107244043e-05]
["Serpinh1","serine (or cysteine) peptidase inhibitor, clade H, member 1 Gene",12406,63,4,8,7.83492252260246e-05]
["Ifih1","interferon induced with helicase C domain 1 Gene",71586,33,0,6,8.02817002681399e-05]
["1110051M20Rik","RIKEN cDNA 1110051M20 gene Gene",228356,33,0,6,8.02817002681399e-05]
["Ttll12","tubulin tyrosine ligase-like family, member 12 Gene",223723,21,0,5,8.24872477378765e-05]
["Aqp8","aquaporin 8 Gene",11833,34,1,6,9.564642743607259e-05]
["Cldn1","claudin 1 Gene",12737,34,1,6,9.564642743607259e-05]
["Nr1d1","nuclear receptor subfamily 1, group D, member 1 Gene",217166,34,3,6,9.564642743607259e-05]
["Ghr","growth hormone receptor Gene",14600,65,0,8,9.81694783295769e-05]
["R3hdm2","R3H domain containing 2 Gene",71750,49,0,7,0.000102343409279201]
["Hipk2","homeodomain interacting protein kinase 2 Gene",15258,36,0,6,0.000133350293010672]
["Rsc1a1","regulatory solute carrier protein, family 1, member 1 Gene",69994,13,0,4,0.000149353479370919]
["Cyp2f2","cytochrome P450, family 2, subfamily f, polypeptide 2 Gene",13107,37,0,6,0.00015616246463454202]
["Cxcl9","chemokine (C-X-C motif) ligand 9 Gene",17329,37,0,6,0.00015616246463454202]
["Hsd3b2","hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Gene",15493,24,0,5,0.00016297222194164]
["Mup4","major urinary protein 4 Gene",17843,24,0,5,0.00016297222194164]
["Extl1","exostoses (multiple)-like 1 Gene",56219,24,1,5,0.00016297222194164]
["Sc5d","sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) Gene",235293,38,0,6,0.00018195195717315402]
["G6pdx","glucose-6-phosphate dehydrogenase X-linked Gene",14381,54,2,7,0.00019152267103471202]
["Scrt1","scratch homolog 1, zinc finger protein (Drosophila) Gene",170729,25,0,5,0.000199976855244113]
["Ptprj","protein tyrosine phosphatase, receptor type, J Gene",668629,14,1,4,0.000205397404528152]
["Psmb8","proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Gene",16913,39,0,6,0.000210987962933253]
["Slc10a2","solute carrier family 10, member 2 Gene",20494,39,0,6,0.000210987962933253]
["Actg1","actin, gamma, cytoplasmic 1 Gene",11465,55,1,7,0.00021524765671899403]
["Comt1","catechol-O-methyltransferase 1 Gene",12846,55,2,7,0.00021524765671899403]
["Ntn3","netrin 3 Gene",18209,15,0,4,0.000275138427841996]
["2900086B20Rik","RIKEN cDNA 2900086B20 gene",73074,15,0,4,0.000275138427841996]
["Stac3","SH3 and cysteine rich domain 3 Gene",237611,15,0,4,0.000275138427841996]
["Mmp15","matrix metallopeptidase 15 Gene",17388,27,0,5,0.000292820465734021]
["Gtf2ird1","general transcription factor II I repeat domain-containing 1 Gene",57080,27,0,5,0.000292820465734021]
["Phf19","PHD finger protein 19 Gene",74016,27,0,5,0.000292820465734021]
["Inhbe","inhibin beta E Gene",16326,42,2,6,0.00032046105972868903]
["Col3a1","collagen, type III, alpha 1 Gene",12825,59,1,7,0.00033493526437377403]
["Cdc42ep2","CDC42 effector protein (Rho GTPase binding) 2 Gene",104252,28,1,5,0.00034994684197209503]
["1110054M08Rik","RIKEN cDNA 1110054M08 gene",68841,16,1,4,0.00036037436667954605]
["2810051F02Rik","RIKEN cDNA 2810051F02 gene",72704,7,0,3,0.00036083864999280805]
["Gm13768","predicted gene 13768",627525,7,0,3,0.00036083864999280805]
["Gm7450","predicted gene 7450",665017,7,0,3,0.00036083864999280805]
["LOC677259","similar to Ornithine decarboxylase (ODC)",677259,7,0,3,0.00036083864999280805]
["LOC100045005","similar to Deltex3",100045005,7,0,3,0.00036083864999280805]
["Dnase1l2","deoxyribonuclease 1-like 2 Gene",100047816,7,0,3,0.00036083864999280805]
["LOC100048733","similar to WAP four-disulfide core domain 2",100048733,7,0,3,0.00036083864999280805]
["D0H4S114","DNA segment, human D4S114 Gene",27528,60,0,7,0.00037191962929051804]
["Litaf","LPS-induced TN factor Gene",56722,60,0,7,0.00037191962929051804]
["Pdia3","protein disulfide isomerase associated 3 Gene",14827,62,0,7,0.00045566912707227904]
["Ly6e","lymphocyte antigen 6 complex, locus E Gene",17069,62,2,7,0.00045566912707227904]
["Hspb7","heat shock protein family, member 7 (cardiovascular) Gene",29818,30,1,5,0.000489018668193361]