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["Table S6: TFs with binding sites enriched among genes overexpressed (a,) and underexpressed (b,) in CR"]
[]
["a, TFs with binding sites enriched among genes overexpressed in CR"]
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["Gene symbol","BKL description"]
["Arnt","Aryl hydrocarbon receptor nuclear translocator; a transcriptional activator that acts in angiogenesis; cell fate determination; and placenta development; human ARNT is associated with type 2 diabetes; breast neoplasms; and leiomyoma"]
["Bptf","Bromodomain PHD finger transcription factor; an nucleosome-dependent ATPase that functions in chromatin remodeling; neurite outgrowth; and embryonic placenta development; human BPTF is associated with amyotrophic lateral sclerosis and Alzheimer disease"]
["Cux1","Cut-like homeobox 1; a transcription regulator that regulates cell cycle; immune response; macrophage and monocyte differentiation; lung development; epithelial cell differentiation; and post-embryonic morphogenesis"]
["Fam71f2","Synthetic high osmolarity-sensitive 1 (by homology to C. albicans Sho1p); a predicted osmosensor in the HOG1 MAP kinase high-osmolarity signal transduction pathway"]
["Foxa1","Forkhead box A1; a transcription factor that plays role in renal water homeostasis; neuron development; and prostate gland development; human FOXA1 is associated with esophageal; lung; and various cancers"]
["Foxa2","Forkhead box A2; transcription factor; acts in notochord development; lung maturation; and body axis formation; regulates insulin secretion; glucose homeostasis and cell differentiation; human FOXA2 expression is altered in several types of cancers"]
["Foxa3","Forkhead box A3; a transcription activator that plays a role in glucose homeostasis and spermatogenesis; increased mRNA expression correlates with liver tumors"]
["Max","Max protein; a transcriptional activator that plays a role in myeloid cell differentiation; involved in in-utero embryonic development; neuropeptide signaling pathway; human MAX is associated with myeloid leukemia; lymphoma; lung; and breast neoplasms"]
["Mtf1","Metal response element binding transcription factor 1; a transcription activator that acts in cellular anti cadmium defense and zinc ion homeostasis; acts in liver development; heavy metal detoxification; hematopoiesis; and EGF dependent DNA synthesis"]
["Myc","Myelocytomatosis oncogene; a transcription factor that acts in apoptosis; telomeric organization; and G1-S transition of mitotic cell cycle; regulates cell size; human MYC is associated with arthritis; AIDS; xeroderma pigmentosum; and several neoplasms"]
["Mycn","Neuroblastoma derived v-myc myelocytomatosis viral related oncogene; a transcription repressor that mediates central nervous system development; ribosome biogenesis and assembly; human MYCN is associated with Wilms tumor and several cancers"]
["Nfatc1","Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1; a transcription factor that acts in cell differentiation; cell proliferation; and regulation of bone remodeling; gene deletion correlates with osteopetrosis"]
["Nfatc2","Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2; a transcriptional regulator that acts in T cell activation; apoptosis; and regulation of cytokine biosynthesis; human NFATC2 is associated with breast neoplasm"]
["Nfatc3","Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3; a transcription activator that acts in heart development; T cell differentiation; and muscle cell proliferation; genetic knockout is associated with aggressive mammary adenocarcinoma"]
["Nfatc4","Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 4; a transcriptional coactivator that regulates skeletal muscle differentiation and heart development; human NFATC4 is associated with breast neoplasms and cardiomegaly"]
["Nr2f1","Nuclear receptor subfamily 2 group F member 1; a transcriptional repressor that plays a role in axon guidance; brain development; and regulation of oligodendrocyte differentiation; human NR2F1 is associated with adrenal cortex neoplasms"]
["Nr2f2","Nuclear receptor subfamily 2 group F member 2; a transcriptional regulator that plays a role in angiogenesis; embryo implantation; and glucose homeostasis; human NR2F2 is associated with adrenal cortex neoplasms"]
["Pax2","Paired box gene 2; a transcription regulator that plays a role in kidney development and antiapoptosis; regulates organ growth and DNA binding; human PAX2 is associated with oligomeganephronia; coloboma; renal cell carcinoma; and kidney neoplasms"]
["Smad1","MAD homolog 1; a transcriptional regulator that acts in antiapoptosis; BMP signaling pathway; brain development; cell fate commitment; transforming growth factor beta receptor signaling pathway; and regulation of osteoblast differentiation"]
["Smad2","MAD homolog 2; a transcription coactivator that acts in erythrocyte differentiation and spermatogenesis; human SMAD2 is associated with colorectal neoplasms; rheumatoid arthritis; and lung neoplasms"]
["Smad3","MAD homolog 3; a transcription factor that acts in liver development; T cell activation; transforming growth factor beta receptor signaling pathway; and regulates cell growth; human SMAD3 is associated with prostate cancer and several other neoplasms"]
["Smad4","SMAD family member 4; a transcriptional regulator that acts in BMP signaling and organ development; regulates neural crest cell migration; heart growth; neurogenesis; and apoptosis; human SMAD4 is associated with several cancers"]
["Smad5","MAD homolog 5; a TGF-beta receptor cytoplasmic mediator that plays a role in osteoblast cell differentiation; vasculogenesis; embryonic and germ cell development; embryo implantation; angiogenesis; and determination of left-right symmetry"]
["Smad6","MAD homolog 6; a transcription corepressor that inhibits BMP signaling pathway; regulates cell proliferation and blood pressure; plays a role in heart and skeletal development; human SMAD6 is associated with heart disease and neoplasms"]
["Smad7","MAD homolog 7; antagonizes TGF beta family-mediated signaling; regulates apoptosis; inflammatory responses; and preimplantation development; human MADH7 is associated with inflammatory bowel disease; scleroderma; and several cancers"]
["Smad9","MAD homolog 9; a transcription coactivator that plays a role in transforming growth factor beta receptor complex assembly; regulates BMP signaling pathway; cell proliferation; and hydrolase activity; human SMAD9 is downregulated in several neoplasms"]
["Tcfcp2","Transcription factor CP2; an RNA polymerase II transcription factor that plays a role in osteoblast and erythrocyte differentiation; negatively regulates transcription from RNA polymerase II promoter; human TFCP2 is associated with Alzheimers disease"]
["Usf1","Upstream stimulatory factor 1; a transcription coactivator that regulates transcription from RNA polymerase II promoter; human USF1 is associated with breast neoplasms; cardiovascular diseases; and familial combined hyperlipidemia"]
["Usf2","Upstream transcription factor 2; a transcription activator that plays a role in central nervous system and utero embryonic development and lactose biosynthetic process; human USF2 is associated with hydronephrosis"]
[]
["b, TFs with binding sites enriched among genes underexpressed in CR"]
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["Gene symbol","BKL description"]
["Ahr","Aryl hydrocarbon receptor; a transcription regulator that acts in cell cycle; apoptosis; blood vessel patterning; circadian behavior; and inflammatory response; protects from bacterial infections; human AHR is associated with breast and prostate cancers"]
["Arnt","Aryl hydrocarbon receptor nuclear translocator; a transcriptional activator that acts in angiogenesis; cell fate determination; and placenta development; human ARNT is associated with type 2 diabetes; breast neoplasms; and leiomyoma"]
["Bach1","BTB and CNC homology 1; a transcriptional regulator that functions in megakaryocyte differentiation; phagocytosis; and smooth muscle cell proliferation; human BACH1 is associated with Down syndrome"]
["Bach2","BTB and CNC homology 2; a transcriptional regulator that plays a role in the induction of apoptosis; somatic recombination of immunoglobulin gene segments; and negative regulation of cell differentiation; human BACH2 is associated with ovarian cancer"]
["Fos","FBJ osteosarcoma oncogene; a DNA binding transcription factor that acts in cell proliferation and cell differentiation; human FOS is associated with atherosclerosis; asthma; Alzheimer disease; breast and several neoplasms"]
["Fosb","FBJ osteosarcoma viral oncogene homolog B; a transcriptional regulator that forms AP-1 transcription factor complex with Jun proteins; acts in ossification; behavior; circadian sleep cycle; and apoptosis; human FOSB is upregulated in breast neoplasms"]
["Fosl1","Fos like antigen 1; a transcription coactivator; expression is elevated in breast cancer and gene knockout correlates with osteopenia; human FOSL1 is associated with several cancers; rat Fosl1 is associated with ischemia and asbestos induced mesothelioma"]
["Fosl2","FOS-like antigen 2; a transcription factor that regulates cell cycle and size; may play a role in circadian rhythm; cell differentiation; and proliferation; acts in the development of pulmonary fibrosis; human FOSL2 is upregulated in breast neoplasms"]
["Hnf4a","Hepatic nuclear factor 4 alpha; a transcription factor that promotes insulin secretion; functions in hepatocyte differentiation; glucose metabolism; and bile acid conjugation; human HNF4A gene is associated with type 2 diabetes and hepatocellular cancer"]
["Hnf4g","Hepatocyte nuclear factor 4 gamma; a transcriptional activator that plays a role in regulation of body size; locomotion; metabolic process; and respiratory gaseous exchange; may act in intracellular receptor-mediated signaling pathway"]
["Hsf1","Heat shock factor 1; a transcription factor that acts in apoptosis and glucose metabolism; involved in response to heat and oxidative stress; human HSF1 is associated with malignant form of prostatic neoplasms and stress"]
["Hsf2","Heat shock transcription factor 2; a transcriptional activator that regulates JNK cascade; plays a role in antiapoptosis; brain development; synaptonemal complex assembly; ovulation; and spermatogenesis"]
["Jun","Jun oncogene; a transcription activator that acts in antiapoptosis and regulation of cell growth; human JUN is associated with Alzheimer disease; multiple sclerosis; glomerulonephritis; schizophrenia; psoriasis; prostatic and several neoplasms"]
["Junb","Jun-B oncogene; a transcription activator; acts in angiogenesis; blood vessel development; and regulation of cell proliferation; human JUNB is associated with atopic dermatitis; psoriasis; Sezary syndrome; mycosis fungoides; ovarian and several neoplasms"]
["Jund","Jun proto oncogene related gene d; a transcription activator that acts in cytokine-mediated signaling pathway; induction of apoptosis; and regulation of epithelial cell proliferation; human JUND is associated with breast neoplasms and cardiomyopathy"]
["Maf","Homolog of avian musculoaponeurotic fibrosarcoma AS42 oncogene; a transcription factor that acts in eye development and regulation of cell differentiation; human MAF is associated with cataract; microphthalmos; T-cell lymphoma and several other neoplasms"]
["Mafb","Protein B of v-maf musculoaponeurotic fibrosarcoma oncogene family; a transcriptional factor that acts in macrophage differentiation and regulation of respiratory gaseous exchange; human MAFB is associated with Dupuytren disease and multiple myeloma"]
["Maff","Protein F of v-maf musculoaponeurotic fibrosarcoma oncogene family; a transcription cofactor that is involved in response to cytokine stimulus"]
["Mafg","Homolog G of v-maf musculoaponeurotic fibrosarcoma oncogene; an RNA polymerase II transcription factor that plays a role in erythrocyte differentiation; NLS-bearing substrate import into nucleus; platelet formation; and megakaryocyte differentiation"]
["Mafk","Protein K of v-maf musculoaponeurotic fibrosarcoma oncogene family; a transcription factor that plays a role in erythrocyte differentiation; hemopoiesis; and neuron projection morphogenesis; regulates DNA binding; gluconeogenesis; and insulin secretion"]
["Nfe2","Nuclear factor erythroid derived 2; a transcription factor that plays a role in blood coagulation; erythrocyte development; hemostasis; megakaryocyte differentiation; and regulation of cell proliferation; human NFE2 is associated with thrombocytopenia"]
["Nfe2l1","Nuclear factor erythroid derived 2-like 1; a transcriptional regulator that plays a role in erythrocyte differentiation; inflammatory responses; mitochondrial genome maintenance; and glutathione biosynthesis; may act in cell redox and lipid homeostasis"]
["Nfe2l2","Nuclear factor erythroid derived 2 like 2; a transcription factor that is involved in response to oxidative stress; arsenic; and toxin; acts in DNA protection; hemopoiesis; and cell cycle arrest; human NFE2L2 is associated with colorectal adenoma"]
["Nfe2l3","Nuclear factor erythroid-derived 2 like 3; a transcription activator that plays a role in transcription from RNA polymerase II promoter; may be involved in wound healing"]
["Nfya","Nuclear transcription factor Y alpha; functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA; may play a role in myeloid cell differentiation; human NFYA is associated with squamous cell carcinoma"]
["Nfyb","Nuclear transcription factor Y beta; a histone acetyltransferase binding protein that regulates cell proliferation and G1-S transition of mitotic cell cycle; plays a role in protein hetero-oligomerization by forming a heterotrimer with Nfya and Nfyc"]
["Nfyc","Nuclear transcription factor-Y gamma; a transcriptional coactivator that is involved in response to unfolded protein; may act in cell differentiation; protein folding; and regulation of cell cycle; human NFYC is associated with nonsmall cell lung cancer"]
["Nr2f1","Nuclear receptor subfamily 2 group F member 1; a transcriptional repressor that plays a role in axon guidance; brain development; and regulation of oligodendrocyte differentiation; human NR2F1 is associated with adrenal cortex neoplasms"]
["Nr2f2","Nuclear receptor subfamily 2 group F member 2; a transcriptional regulator that plays a role in angiogenesis; embryo implantation; and glucose homeostasis; human NR2F2 is associated with adrenal cortex neoplasms"]
["Ppara","Peroxisome proliferator-activated receptor alpha; acts in lipid metabolism; genetic knockdown causes hypoglycemia and hypertriglyceridemia; human PPARA is associated with prostate cancer; arteriosclerosis; syndrome-X; myocardial ischemia; and diabetes"]
["Ppard","Peroxisome proliferator activator receptor delta; a transcription factor; regulates apoptosis; cell proliferation and keratinocyte differentiation; acts in fatty acid metabolism and angiogenesis; human PPARD is associated with psoriasis and several tumors"]
["Pparg","Peroxisome proliferator activated receptor gamma; a transcription factor that acts in lipid metabolism and cell death; genetic knockout causes colitis and obesity; human PPARG is associated with edema and obesity in type 2 diabetes and various neoplasms"]
["Sp3","Trans-acting transcription factor 3; a transcriptional regulator that plays a role in hemopoiesis; neuron differentiation; and osteoblast differentiation; human SP3 decreased gene expression correlates with multiple sclerosis"]
["Spz1","Spermatogenic Zip 1; an E box-binding bHLH Zip transcription factor that also binds and negatively regulates the activity of protein phosphatase 1c-gamma (Ppp1cc); promotes cell proliferation; transformation and tumorigenesis; important in spermatogenesis"]
["Srebf1","Sterol regulatory element binding transcription factor 1; a transcription regulator that regulates feeding behavior and lipid metabolism; human SREBF1 is associated with diabetes mellitus type II; obesity; HIV infections; and prostatic neoplasms"]
["Srebf2","Sterol regulatory element binding transcription factor 2; a transcriptional activator that is involved in cholesterol and fatty acid biosynthesis; human SREBF2 is associated with hypercholesterolaemia; rat Srebf2 is associated with chronic renal failure"]
["Srf","Serum response factor; an enhancer binding RNA polymerase II transcription factor that inhibits apoptosis; mediates muscle development; cell differentiation; and sprouting angiogenesis; human SRF is associated with hepatocellular carcinomas"]
["Tcfcp2","Transcription factor CP2; an RNA polymerase II transcription factor that plays a role in osteoblast and erythrocyte differentiation; negatively regulates transcription from RNA polymerase II promoter; human TFCP2 is associated with Alzheimers disease"]
["Zbtb7a","Zinc finger and BTB domain containing 7a; a member of the POK subfamily of kruppel-like Zn-finger proteins that binds to histone deacetylase Hdac1; represses Comp gene expression and chondrocyte differentiation; human ZBTB7A is upregulated in cancers"]
["Zhx1","Zinc-fingers and homeoboxes 1; a transcription factor that is involved in cellular response to interleukin 2 (Il2); contains two zinc finger and five homeodomain motifs"]