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["Electronic Supplementary Material (ESI) for Molecular BioSystems"]
["This journal is © The Royal Society of Chemistry 2012"]
[]
["Simple Molecules"]
["Used name","Recommended name (UniProt)","official gene name (HGNC)","Type of molecule/location","Identifier*","*Type of identificator "]
["ADAM17*(pm)","Disintegrin and metalloproteinase domain-containing protein 17","ADAM17","activated","P78536","proteins: Uniprot accession number"]
["Afadin(c)","Afadin","MLLT4","cytoplasm","P55196","genes: ENSEMBL gene id"]
["AKT*(c)","RAC-alpha serine/threonine-protein kinase","AKT1","activated / cytoplasm","P31749","enzymes: EC number"]
["AKT*(pm)","RAC-alpha serine/threonine-protein kinase","AKT1","activated / plasmatic membrane","P31749"]
["alpha5(pm)","integrin, alpha 5 (fibronectin receptor, alpha polypeptide)","Integrin alpha-5","plasmatic membrane","P08648"]
["alpha-actinin(c)","Alpha-actinin-1","ACTN1","cytoplasm","P12814"]
["alpha-actinin(pm)","Alpha-actinin-1","ACTN1","plasmatic membrane","P12814"]
["alpha-actininP(Tyr12)(pm)","Alpha-actinin-1","ACTN1","phosphorylated / plasmatic membrane","P12814"]
["alpha-actininP(Tyr4,31)(c)","Alpha-actinin-1","ACTN1","phosphorylated / cytoplasm","P12814"]
["alpha-actininP(Tyr4,31)(pm)","Alpha-actinin-1","ACTN1","phosphorylated / plasmatic membrane","P12814"]
["alpha-catenin(c)","Catenin alpha-1","CTNNA1","cytoplasm","P35221"]
["alpha-catenin(n)","Catenin alpha-1","CTNNA1","nucleus","P35221"]
["alpha-cateninP(Ser641)","Catenin alpha-1","CTNNA1","phosphorylated","P35221"]
["alpha-cateninP(Tyr142)(c)","Catenin alpha-1","CTNNA1","phosphorylated / cytoplasm","P35221"]
["AP-2(n)","Transcription factor AP-2-alpha","TFAP2A","nucleus","P05549"]
["APC(c)","Adenomatous polyposis coli protein","APC","cytoplasm","P25054"]
["ARF(c)","Cyclin-dependent kinase inhibitor 2A, isoform 4","p14ARF","cytoplasm","Q8N726"]
["ARF(gen)","CDKN2A","CDKN2A","gene","ENSG00000147889"]
["ARF6*","ADP-ribosylation factor 6","ARF6","activated","P62330"]
["ARF6*(pm)","ADP-ribosylation factor 6","ARF6","activated / plasmatic membrane","P62330"]
["ARP2,3*(c)","ARP2 actin-related protein 2 homolog (yeast)","ARP2","activated/cytoplasm","P61160"]
["ARP2,3*(c)","ARP2 actin-related protein 3 homolog (yeast)","ARP3","activated/cytoplasm","P61158"]
["ASEF(GEF)","Rho guanine nucleotide exchange factor 4","ARHGEF4",null,"Q9NR80"]
["AuroraA*(c)","Serine/threonine-protein kinase 6","AURKA","activated / cytoplasm","O14965"]
["Axin1/2(c)","Axin-1","AXIN1","cytoplasm","O15169"]
[null,"Axin-2","AXIN2",null,"Q9Y2T1"]
["Bcl2(c)","Apoptosis regulator Bcl-2","BLC2","cytoplasm","P10415"]
["Bcl9(n)","B-cell CLL/lymphoma 9 protein","BLC9","nucleus","P10415"]
["beta1integrin(pm)","Integrin beta-1","ITGB1","plasmatic membrane","O00512"]
["ß-catenin(c)","Catenin beta-1","CTNNB1","cytoplasm","P35222"]
["ß-catenin(catabolized)","Catenin beta-1","CTNNB1","catabolized","P35223"]
["ß-catenin(n)","Catenin beta-1","CTNNB1","nucleus","P35224"]
["ß-cateninP(Tyr142)(c)","Catenin beta-1","CTNNB1","phosphorylated / cytoplasm","P35225"]
["ß-cateninP(Tyr489)(c)","Catenin beta-1","CTNNB1","phosphorylated / cytoplasm","P35226"]
["ß-cateninP(Tyr654)(c)","Catenin beta-1","CTNNB1","phosphorylated / cytoplasm","P35227"]
["b-Raf(c)","Serine/threonine-protein kinase B-raf","BRAF","cytoplasm","P15056"]
["b-Raf*(c)","Serine/threonine-protein kinase B-raf","BRAF","activated / cytoplasm","P15056"]
["C3G(pm)","Rap guanine nucleotide exchange factor 1","RAPGEF1","plasmatic membrane","Q13905"]
["CaMK*(c)","calcium/calmodulin-dependent protein kinase II alpha","CAMK-II","activated / cytoplasm","EC 2.7.11"]
["Caspase3*","Caspase-3","CASP3","activated","P42574"]
["Caveolin(c)","Caveolin-1","CAV1","cytoplasm","Q03135"]
["Caveolin(gen)","Caveolin-1","CAV1","gene","ENSG00000105974"]
["Caveolin(pm)","Caveolin-1","CAV1","plasmatic membrane","Q03135"]
["CaveolinP(Tyr14)(c)","Caveolin-1","CAV1","phosphorylated / cytoplasm","Q03135"]
["CaveolinP(Tyr14)(pm)","Caveolin-1","CAV1","phosphorylated / plasmatic membrane","Q03135"]
["CDC42(pm)","Cell division control protein 42 homolog","CDC42","plasmatic membrane","P60953"]
["CDC42*(AJ)","Cell division control protein 42 homolog","CDC42","activated / adherens junctions","P60953"]
["CDC42*(lamellipodia)","Cell division control protein 42 homolog","CDC42","activated / lamellipodia","P60953"]
["CdhE(c)","Cadherin-1","CDH1","cytoplasm","P12830"]
["CdhE(catabolized1)","Cadherin-1","CDH1","degradation of CdhE fraction internalized via caveolin","P12830"]
["CdhE(catabolized2)","Cadherin-1","CDH1","degradation of CdhE fraction internalized via clathrin","P12830"]
["CdhE(endocythosis1)","Cadherin-1","CDH1","internalization of CdhE by caveolin","P12830"]
["CdhE(endocythosis2)","Cadherin-1","CDH1","internalization of CdhE by clathrin","P12830"]
["CdhE(gen)","Cadherin-1","CDH1","gene","ENSG00000039068"]
["CdhE(recycled1)","Cadherin-1","CDH1","fraction of CdhE that is internalized by caveolin and recycled through  Ral-A(c) +  Rab11 ","P12830"]
["CdhE(recycled2)","Cadherin-1","CDH1","fraction of CdhE that is internalized by clathrin and recycled through  Ral-A(c) +  Rab12","P12830"]
["CdhEP(Ser684,686,692)(c)","Cadherin-1","CDH1","phosphorylated / cytoplasm","P12830"]
["CdhEshedding","Cadherin-1","CDH1","shedding of CdhE","P12830"]
["CdhP(c)","Cadherin-3","CDH3","phosphorylated / cytoplasm","P22223"]
["CDX1,2(n)","Homeobox protein CDX-1","CDX1","nucleus","P12830"]
[null,"Homeobox protein CDX-2","CDX2","nucleus","Q99626"]
["C-EBPalpha,beta(n)","CCAAT/enhancer-binding protein alpha","CEBPA","nucleus","P49715"]
[null,"CCAAT/enhancer-binding protein beta","CEBPB","nucleus","P17676"]
["c-GMP","cGMP-dependent protein kinase 1","PRKG1",null,"Q13976"]
["CITED2(n)","Cbp/p300-interacting transactivator 2","CITED2","nucleus","Q99967"]
["CKII(c)","Casein kinase II subunit alpha","CSNK2A2","cytoplasm","EC 2.7.11"]
["CKIIP(c)","Casein kinase II subunit alpha","CSNK2A2","phosphorylated / cytoplasm","P19784"]
["clathrin(c)","Clathrin heavy chain 2","CLTCL1","cytoplasm","P53675"]
["Claudin(c)","Claudin",null,"claudin family (except claudin-1) / gene","O95832"]
["Claudin(gen)","Claudin",null,"claudin family (except claudin-1) / cytoplasm","ENSG00000163347"]
["Claudin-1(c)","Claudin-1","CLDN1","cytoplasm","O95832"]
["Claudin-1(n)","Claudin-1","CLDN1","nucleus","O95832"]
["c-Met(pm)","Hepatocyte growth factor receptor","MET","plasmatic membrane","P08581"]
["c-Met*(pm)","Hepatocyte growth factor receptor","MET","activated / plasmatic membrane","P08581"]
["Cofilin(c)","Cofilin-1","CFL1","cytoplasm","P23528"]
["CollagenI(ec)","Collagen alpha-1(I) chain","COL1A1","extracellular","P02452"]
["Contactin(c)","Contactin-1","CNTN1","cytoplasm","Q12860"]
["c-RAF*(c)","RAF proto-oncogene serine/threonine-protein kinase","RAF1","cytoplasm","P04049"]
["CREB(n)","Cyclic AMP-responsive element-binding protein 1","CREB1","nucleus","P16220"]
["CRK","Adapter molecule crk","CRK",null,"P46108"]
["c-Src*(AJ)","Proto-oncogene tyrosine-protein kinase Src","SRC","adherens junctions","P12931"]
["c-Src*(pm)","Proto-oncogene tyrosine-protein kinase Src","SRC","plasmatic membrane","P12931"]
["CTBP(n)","C-terminal-binding protein 1","CTBP1","nucleus","Q13363"]
["CXCR4*(pm)","C-X-C chemokine receptor type 4","CXCR4","plasmatic membrane","P61073"]
["delta-APC(c)","Adenomatous polyposis coli protein","APC","mutated form / cytoplasm","P25054"]
["Delta-Gli-3(n)","Transcriptional activator GLI3","GLI3","mutated form / nucleus","P10071"]
["DeltaN-LEF1(n)","Lymphoid enhancer-binding factor 1","LEF1","Aberrant, N-terminal deleted form","Q9UJU2 "]
["dn-TCF1E(n)","Hepatocyte nuclear factor 1-alpha","HNF1A","dominant negative  form / nucleus","P20823"]
["DSC(c)","Desmocollin-1","DSC1","cytoplasm","Q08554"]
["DSC(gen)","Desmocollin-1","DSC1","gene","ENSG00000134765"]
["DSG(c)","Desmoglein-1","DSG1","cytoplasm","Q02413"]
["DSGshedding","Desmoglein-1","DSG1","shedding of DSG","Q02413"]
["Dsh*(c)","Dishevelled, dsh homolog 1 (Drosophila)","DVL1 ","activated / cytoplasm","Q86TH3"]
["dynamin(c)","Dynamin-1","DNM1","cytoplasm","P21575"]
["EGF(ec)","Pro-epidermal growth factor","EGF","extracellular","P01133"]
["EGFR(pm)","Epidermal growth factor receptor","EGFR","plasmatic membrane","P00533"]
["EGFR*(pm)","Epidermal growth factor receptor","EGFR","activated / plasmatic membrane","P00533"]
["EPLIN(c)","LIM domain and actin-binding protein 1","LIMA1","cytoplasm","Q9UHB6"]
["ER(gen)","Estrogen receptor","ESR1","gene","ENSG00000091831"]
["ER(nm)","Estrogen receptor","ESR1","nuclear membrane","P03372"]
["ER*(nm)","Estrogen receptor","ESR1","activated / nuclear membrane","P03372"]
["ERK1,2*(c)","Mitogen-activated protein kinase 3","MAPK3","activated / cytoplasm","P27361"]
[null,"Mitogen-activated protein kinase 1","MAPK1","cytoplasm","P28482"]
["ERK1,2*(n)","Mitogen-activated protein kinase 3","MAPK3","activated / nucleus","P27361"]
[null,"Mitogen-activated protein kinase 1","MAPK1","nucleus","P28482"]
["FAK(gen)","Focal adhesion kinase 1","PTK2","gene","ENSG00000169398"]
["FAK1(c)","Focal adhesion kinase 1","PTK2","cytoplasm","Q05397"]
["FAK1P(Ser910,843)(pm)","Focal adhesion kinase 1","PTK2","phosphorylated / plasmatic membrane","Q05397"]
["FAK1P(Tyr397)(pm)","Focal adhesion kinase 1","PTK2","phosphorylated / plasmatic membrane","Q05397"]
["Fascin(c)","Fascin","FSCN1","cytoplasm","Q16658"]
["Fascin(gen)","Fascin","FSCN1","gene","ENSG00000075618"]
["FascinP(c)","Fascin","FSCN1","phosphorylated / cytoplasm","Q16658"]
["FER*(pm)","Tyrosine-protein kinase Fer","FER","activated / plasmatic membrane","P16591"]
["Fibronectin(ec)","Fibronectin","FN1","extracellular","P02751"]
["Fibronectin(endocyted_catabolized)","Fibronectin","FN1","degradation of fibronectin after being internalized","P02751"]
["Frz(gen)","Frizzled-1","FZD1","gene","ENSG00000157240"]
["Frz3(pm)","Frizzled-3","FZD3","plasmatic membrane","Q9NPG1"]
["fyn*(pm)","Tyrosine-protein kinase Fyn","FYN","plasmatic membrane","P06241"]
["GATA1,2,3(n)","Erythroid transcription factor","GATA1","nucleus","P15976"]
[null,"Endothelial transcription factor GATA-2","GATA2","nucleus","P23769"]
[null,"Trans-acting T-cell-specific transcription factor GATA-3","GATA3","nucleus","P23771"]
["Gli-1(n)","Zinc finger protein GLI1","GLI1","nucleus","P08151"]
["Gli-3(n)","Transcriptional activator GLI3","GLI3","nucleus","P10071"]
["GPCR(pm)","G-protein coupled bile acid receptor 1","GPBAR1","plasmatic membrane","Q8TDU6"]
["GPCR*(pm)","G-protein coupled bile acid receptor 1","GPBAR1","activated / plasmatic membrane","Q8TDU6"]
["GR(c)","Glucocorticoid receptor","NR3C1","cytoplasm","P04150"]
["GR*(n)","Glucocorticoid receptor","NR3C1","nucleus","P04150"]
["Grb2(pm)","Growth factor receptor-bound protein 2","GRB2","plasmatic membrane","P62993"]
["GRFras(gef)","Ras-specific guanine nucleotide-releasing factor 1","RASGRF1","gef = guanine nucleotide exchange factor","Q13972"]
["Groucho(c)","Transducin-like enhancer protein 2","TLE2","cytoplasm","Q04725"]
["Groucho(n)","Transducin-like enhancer protein 2","TLE2","nucleus","Q04725"]
["GSK3beta(c)","GSK3B ","GSK3B","cytoplasm","Q6FI27"]
["GSK3betaP(inactive)","GSK3B ","GSK3B","phosphorylated / inactive","Q6FI27"]
["Hakai(c)","E3 ubiquitin-protein ligase Hakai","CBLL1","cytoplasm","Q75N03"]
["HDAC1(n)","Histone deacetylase 1","HDAC1","nucleus","Q13547"]
["HGF(ec)","Hepatocyte growth factor","HGF","extracellular","P14210 "]
["HNF3(n)","Hepatocyte nuclear factor 3-alpha","FOXA1","nucleus","P55317"]
["ICAT(n)","Beta-catenin-interacting protein 1","CTNNBIP1","nucleus","Q9NSA3"]
["IGF1R*(pm)","Insulin-like growth factor 1 receptor","IGF1R","activated / plasmatic membrane","P08069"]
["ILK(c)","Integrin-linked protein kinase","ILK","cytoplasm","Q13418"]
["ILK(gen)","Integrin-linked protein kinase","ILK","gene","ENSG00000166333"]
["ILK*(pm)","Integrin-linked protein kinase","ILK","activated","Q13418"]
["IQGAP1,3(c)","Ras GTPase-activating-like protein IQGAP1","IQGAP1","cytoplasm","P46940"]
[null,"Ras GTPase-activating-like protein IQGAP3","IQGAP3","cytoplasm","Q86VI3"]
["IQGAP1,3(pm)","Ras GTPase-activating-like protein IQGAP1","IQGAP1","plasmatic membrane","P46940"]
[null,"Ras GTPase-activating-like protein IQGAP3","IQGAP3","plasmatic membrane","Q86VI3"]
["JAM-A(c)","Junctional adhesion molecule A","F11R","cytoplasm","Q9Y624"]
["JAM-A(gen)","Junctional adhesion molecule A","F11R","gene","ENSG00000158769"]
["jub(c)","Protein ajuba","JUB","cytoplasm","Q96IF1"]
["JUBcatabolised","Protein ajuba","JUB",null,"Q96IF1"]
["jubP(c)","Protein ajuba","JUB","phosphorylated / cytoplasm","Q96IF1"]
["KLF4(n)","Krueppel-like factor 4","KLF4","nucleus","O43474"]
["KLF8(n)","Krueppel-like factor 8","KLF8","nucleus","O95600"]
["LATS2*(c)","Serine/threonine-protein kinase LATS2","LATS2","cytoplasm","Q9NRM7"]
["LIMK1*","LIM domain kinase 1","LIMK1","activated","P53667"]
["LIMK2*","LIM domain kinase 2","LIMK2","activated","P53671"]
["LPA(c)","Apolipoprotein(a)","LPA","cytoplasm","P08519"]
["LPA(ec)","Apolipoprotein(a)","LPA","extracellular","P08519"]
["MEK1,2*(c)","Dual specificity mitogen-activated protein kinase kinase 1","MAP2K1","cytoplasm","Q02750"]
[null,"Dual specificity mitogen-activated protein kinase kinase 2","MAP2K2","cytoplasm","P36507"]
["miR-let-7","microRNA let-7a-1","MIRLET7A1","cytoplasm","ENSG00000199165"]
["MMP14(c)","Matrix metalloproteinase-14","MMP14","cytoplasm","P50281"]
["MMP14(ec)","Matrix metalloproteinase-14","MMP14","extracellular","P50281"]
["MMP7(ec)","Matrilysin","MMP7","extracellular","P09237"]
["MMP7(gen)","Matrilysin","MMP7","gene","ENSG00000137673"]
["MMP8(ec)","Neutrophil collagenase","MMP8","extracellular","P22894"]
["MMP9(c)","Matrix metalloproteinase-9","MMP9","cytoplasm","P14780"]
["MMP9(ec)","Matrix metalloproteinase-9","MMP9","extracellular","P14780"]
["MYOII(assembled)","myosin, heavy chain 10, non-muscle","MYH10","assembled","P35580"]
["MYOII(disassembled)","myosin, heavy chain 10, non-muscle","MYH10","disassembled","P35580"]
["Nectin-like(gen)","Cell adhesion molecule 1","CADM1","gene","ENSG00000182985"]
["Nectin-like1/4(pm)","Cell adhesion molecule 1","CADM1","plasmatic membrane","Q9BY67"]
[null,"Cell adhesion molecule 4","CADM4","plasmatic membrane","Q8NFZ8"]
["NLK(c)","Serine/threonine-protein kinase NLK","NLK","cytoplasm","Q9UBE8"]
["N-Myc(n)","N-myc proto-oncogene protein","MYCN","nucleus","P04198"]
["NWASP(c)","Neural Wiskott-Aldrich syndrome protein","WASL","cytoplasm","O00401"]
["Occludin(c)","Occludin","OCLN","cytoplasm","Q16625"]
["Occludin(gen)","Occludin","OCLN","gene","ENSG00000197822"]
["Osteopontin(ec)","Osteopontin","SPP1","extracellular","P10451"]
["p120ctn(c)","Catenin delta-1","CTNND1","cytoplasm","O60716"]
["p120ctn*","Catenin delta-1","CTNND1","activated or mutated","O60716"]
["p120GAP","Ras GTPase-activating protein 1","RASA1",null,"P20936"]
["p120GAP(pm)","Ras GTPase-activating protein 1","RASA1","plasmatic membrane","P20936"]
["p38MAPK*(c)","Mitogen-activated protein kinase 14","MAPK14","cytoplasm","Q16539"]
["p70S6K*(c)","Ribosomal protein S6 kinase beta-2","RPS6KB2","cytoplasm","Q9UBS0"]
["p90(RSK*)(c)","Ribosomal protein S6 kinase alpha-1","RPS6KA1","activated / cytoplasm","Q15418"]
["PAK*","Serine/threonine-protein kinase PAK 1","PAK1","activated","Q13153"]
["PAK*(basal)","Serine/threonine-protein kinase PAK 1","PAK1","activated / basal","Q13153"]
["P-Choline(pm)","phosphocholine",null,"plasmatic membrane","CAS: 107-73-3"]
["PDCD4(n)","Programmed cell death protein 4","PDCD4","nucleus","Q53EL6"]
["PhospolipaseD*(pm)","phospholipase D",null,"enzyme / plasmatic membrane","EC 3.1.4.4"]
["PI3K(c)","Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","PIK3CA","cytoplasm","P42336"]
["PI3K*(AJ)","Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","PIK3CA","adherens junctions","P42336"]
["PI3K*(c)","Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","PIK3CA","cytoplasm","P42336"]
["PKC*(c)","Protein kinase C, alpha","PKC","cytoplasm","EC 2.7.11.133"]
["Plakoglobin(c)","Junction plakoglobin","JUP","cytoplasm","P14923"]
["Plakoglobin(gen)","Junction plakoglobin","JUP","gene","ENSG00000173801"]
["Plakoglobin(n)","Junction plakoglobin","JUP","nucleus","P14923"]
["PlakoglobinP(Tyr549)(c)","Junction plakoglobin","JUP","phosphorylated / cytoplasm","P14923"]
["PlakoglobinP(Tyr643)(c)","Junction plakoglobin","JUP","phosphorylated / cytoplasm","P14923"]
["PlakoglobinP(Tyr693,724,729)","Junction plakoglobin","JUP","phosphorylated","P14923"]
["PLC-gamma*(c)","1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1","PLCG1","activated / cytoplasm","P19174"]
["PML(gen)","Protein PML","PML","gene","ENSG00000140464"]
["PML(n)","Protein PML","PML","nucleus","P29590"]
["PNN(c)","Pinin","PNN","cytoplasm","Q9H307"]
["PPARgamma*(n)","Peroxisome proliferator-activated receptor gamma","PPARG","nucleus","P37231"]
["Prb(n)","Basic salivary proline-rich protein 1","PRB1","nucleus","P04280"]
["profilin(c)","Profilin-1","PFN1","cytoplasm","P07737"]
["profilin(gen)","Profilin-1","PFN1","gene","ENSG00000108518"]
["profilin*(c)","Profilin-1","PFN1","cytoplasm","P07737"]
["Progastrin(ec)","Gastrin","GAST","precursor / extracellular","P01350"]
["ProgastrinR(pm)","Gastrin/cholecystokinin type B receptor","CCKBR","plasmatic membrane","P32239"]
["PTEN(c)","Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN","PTEN","cytoplasm","P60484"]
["PTK6(c)","Protein-tyrosine kinase 6","PTK6","cytoplasm","Q13882"]
["PTK6(n)","Protein-tyrosine kinase 6","PTK6","nucleus","Q13882"]
["PTK6P(inactive)","Protein-tyrosine kinase 6","PTK6","phosphorylated / inactive","Q13882"]
["PTP(pest)","Receptor-type tyrosine-protein phosphatase U","PTPRU",null,"Q92729"]
["PTP(pest)(pm)","Receptor-type tyrosine-protein phosphatase U","PTPRU","plasmatic membrane","Q92729"]
["PTP(pm)","Receptor-type tyrosine-protein phosphatase U","PTPRU","plasmatic membrane","Q92729"]
["PTP1B(inactive)","Tyrosine-protein phosphatase non-receptor type 1","PTPN1","inactive","P18031"]
["PTP1BP(Tyr152)(pm)","Tyrosine-protein phosphatase non-receptor type 1","PTPN1","phosphorylated / plasmatic membrane","P18031"]
["Rab11","Ras-related protein Rab-11A","RAB11A",null,"P62491"]
["Rab5*","Ras-related protein Rab-5A","RAB5A","activated","P20339"]
["RAC1(c)","Ras-related C3 botulinum toxin substrate 1","RAC1","cytoplasm","P63000"]
["RAC1(pm)","Ras-related C3 botulinum toxin substrate 1","RAC1","plasmatic membrane","P63000"]
["RAC1*(AJ)","Ras-related C3 botulinum toxin substrate 1","RAC1","activated / adherens junctions","P63000"]
["RAC1*(llamelopodia)","Ras-related C3 botulinum toxin substrate 1","RAC1","activated / lamellipodia","P63000"]
["RAC1*(pm)","Ras-related C3 botulinum toxin substrate 1","RAC1","activated / plasmatic membrane","P63000"]
["Ral-A(c)","Ras-related protein Ral-A","RALA","cytoplasm","P11233"]
["RAR*(nm)","Retinoic acid receptor alpha","RARA","nuclear membrane","P10276"]
["RAS*(basal)","Ras GTPase-activating protein 1","RASA1","activated / basal","P20936"]
["RAS*(pm)","Ras GTPase-activating protein 1","RASA1","plasmatic membrane","P20936"]
["RhoA(c)","Transforming protein RhoA","RHOA","cytoplasm","P61586"]
["RhoA(pm)","Transforming protein RhoA","RHOA","plasmatic membrane","P61586"]
["RhoA*(AJ)","Transforming protein RhoA","RHOA","activated / adherens junctions","P61586"]
["RhoA*(llamellopodia)","Transforming protein RhoA","RHOA","activated / lamellipodia","P61586"]
["RhoA*(pm)","Transforming protein RhoA","RHOA","plasmatic membrane","P61586"]
["ROS","Proto-oncogene tyrosine-protein kinase ROS","ROS1",null,"P08922"]
["Sec3,8(c)","Exocyst complex component 1","EXOC1","cytoplasm","Q9NV70"]
[null,"Exocyst complex component 4","EXOC4","cytoplasm","Q96A65"]
["SHH(ec)","Sonic hedgehog protein","SHH","extracellular","Q15465"]
["SHP2(c)","Tyrosine-protein phosphatase non-receptor type 11","PTPN11","cytoplasm","Q06124"]
["SNAIL(c)","Zinc finger protein SNAI1","SNAI1","cytoplasm","O95863"]
["SNAIL(gen)","Zinc finger protein SNAI1","SNAI1","gene","ENSG00000124216"]
["SOCS3(c)","Suppressor of cytokine signaling 3","SOCS3","cytoplasm","O14543"]
["SRF(n)","Serum response factor","SRF","nucleus","P11831"]
["Stat3P(n)","Signal transducer and activator of transcription 3","STAT3","phosphorylated / nucleus","P40763"]
["Survivin(c)","Baculoviral IAP repeat-containing protein 5","BIRC5","cytoplasm","O15392"]
["Survivin(gen)","Baculoviral IAP repeat-containing protein 5","BIRC5","gene","ENSG00000089685"]
["TCF4(n)","Transcription factor 4","TCF4","nucleus","P15884"]
["TGFalpha(ec)","Protransforming growth factor alpha","TGFA","extracellular","P01135"]
["TGFbeta(ec)","Transforming growth factor beta-1","TGFB1","extracellular","P01137"]
["TNFalpha(ec)","Tumor necrosis factor","TNF","extracellular","P01375"]
["VAV2(pm)","Guanine nucleotide exchange factor VAV2","VAV2","plasmatic membrane","P52735"]
["VDR*(n)","Vitamin D3 receptor","VDR","activated / nucleus","P11473"]
["Vinculin(c)","Vinculin","VCL","cytoplasm","P18206"]
["Vinculin(gen)","Vinculin","VCL","gene","ENSG00000035403"]
["Vitronectin(ec)","Vitronectin","VTN","extracellular","P04004"]
["VNR(pm)","Integrin alpha-V","ITGAV","plasmatic membrane","P06756"]
["Wnt1(ec)","Proto-oncogene Wnt-1","WNT1","extracellular","P04628"]
["Wnt9b/6(ec)","Protein Wnt-9b","WNT9B","extracellular","O14905"]
[null,"Protein Wnt-6","WNT6","extracellular","Q9Y6F9"]
["ZEB1/2(n)","Zinc finger E-box-binding homeobox 1","ZEB1","nucleus","P37275"]
[null,"Zinc finger E-box-binding homeobox 2","ZEB2","nucleus","O60315"]
["ZO-1(AJ)","Tight junction protein ZO-1","TJP1","adherens junctions","Q07157"]
["ZO-1(c)","Tight junction protein ZO-1","TJP1","cytoplasm","Q07157"]
["ZO-1(gen)","Tight junction protein ZO-1","TJP1","gene","ENSG00000104067"]
["ZO-1P(c)","Tight junction protein ZO-1","TJP1","phosphorylated / cytoplasm","Q07157"]
["ZO-1P(n)","Tight junction protein ZO-1","TJP1","phosphorylated / nucleus","Q07157"]
[]
[]
["Complexes"]
["Used name","Complex compounds (UniProt IDs)","Type of molecule/location"]
["(alpha-catenin)2(c)","CTNNA2","homodimer / cytoplasm"]
["alpha5beta1Integrin(pm)","ITGA5, ITGB1","plasmatic membrane"]
["ß-catenin_FL-TCF1(n)","CTNNB1, HNF1A","nucleus"]
["ß-catenin_TCF4(n)","CTNNB1, TCF4","nucleus"]
["ß-catenin_TCF4_plakoglobin(n)","CTNNB1, TCF4, JUP","nucleus"]
["ß-catenin_TCF4_PML(n)","CTNNB1, TCF4, PML","nucleus"]
["Bundled_Actin","multimer of bundled actin","cytoplasm"]
["Cdhe_ß-catenin(cis)","CDH1, CTNNB1","macromolecular, multimer complex of  Cdhe_betacatenin  at the plasma membrane in a given cell"]
["Cdhe_ß-catenin(pm)","CDH1, CTNNB1","plasmatic membrane"]
["Cdhe_ß-catenin(trans)","CDH1, CTNNB1","homotipic, macromolecular complex of two cis-multimers bridging two faced  cells"]
["Cdhe_ß-catenin_IQGAP(pm)","CDH1, CTNNB1, IQGAP1","plasmatic membrane"]
["Cdhe_Complex(AJ)","CDH1, CTNNB1, CTNND1,TJP1","adherens junctions"]
["c-Met_ß-catenin(pm)","MET, CTNNB1","plasmatic membrane"]
["c-Met_RAP1*(pm)","MET, TERF2IP ","plasmatic membrane"]
["c-Met_Src*(pm)","MET, SRC","plasmatic membrane"]
["CTBP_Repressive_Complex(n)","CTBP1, YY1, YAF2, HDAC4*, HDAC1, HMT1","nucleus"]
["CXCR_Src*(pm)","CXCR1, SRC","plasmatic membrane"]
["Desmosomes(pm)","JUP, DSC1, PNN and more","plasmatic membrane"]
["EGFR_RAP1*(pm)","EGFR, TERF2IP ","plasmatic membrane"]
["EGFR_Src*(pm)","EGFR, SRC","plasmatic membrane"]
["Branched_Polymerized_Actin","multimer of brached  actin","cytoplasm of llamelopodia"]
["FL-TCF1_CTBP_HDAC1(n)","HNF1A, CTBP1, HDAC1","nucleus"]
["FL-TCF1_Groucho_HDAC1(n)","HNF1A, TLE2, HDAC1","nucleus"]
["Gli-1_ß-catenin(n)","Gli1, CTNNB1 ","nucleus"]
["Integrin_Scr*(pm)","ITGxx, SRC","plasmatic membrane"]
["IQGAP_CaMK(c)","IQGAP1,CAMK1","cytoplasm"]
["mTORComplex1(c)","RHEBP1, MTOR, RPTOR,MLST8, AKT1S1, DEPTOR","cytoplasm"]
["Nectin-like1/4(trans)_RAP1*(pm)","CADM1/4, TERF2IP ","complex of two cis-multimers / plasmatic membrane"]
["Nectin-like1/4_Afadin(cis)","CADM1/4, MLLT4","multimer complex at the plasma membrane"]
["Nectin-like1/4(trans)","CADM1/4","macromolecular, homotypic complex between cis-multimers of  Nectin-like protein (1/4 isoforms) "]
["Oct4_Oct4(n)","POU5F1, POU5F1","dimer / nucleus"]
["p53Tetra(n)","TP53","tetramer / nucleus"]
["p73Tetra(n)","TP73","tetramer / nucleus"]
["PIP_Complex","LIMS1, LIMS2, ILK, PARVA"]
["PlakoglobinP(Tyr549)_alpha-catenin(c)","JUP, CTNNA2","cytoplasm"]
["RUNX3_ß-catenin_TCF4(n)","RUNX3, CTNNB1, TCF4","nucleus"]
["TCF4_CTBP_HDAC1(n)","TCF4, CTBP1, HDAC1","nucleus"]
["TCF4_Groucho_HDAC1(n)","TCF4, TLE2, HDAC1","nucleus"]
["TSC2_TSC1(c)","TSC2, TSC1","cytoplasm"]
["β-catenin_TCF4(n)","CTNNB1 , TCF4","nucleus"]
["Cdhe(Trans)","CDH1, CTNNB1","complex of two  Cdhe-betacatenin  cis-multimers bridging two faced cells "]
["Tight_Junction(pm)","Occludin, Claudin, ZO-1, contactin","plasmatic membrane"]

{"sheet":"Reactions","index":1,"n_rows":267,"n_cols":3,"rows_kept":267,"cut":false,"hidden":false,"merged":[[222,0,223,0],[222,1,223,1],[135,0,136,0],[135,1,136,1],[135,2,136,2]],"flags":["formulas_cached_only"]}
[]
["ID","Reactions ","References"]
["R1","SNAIL(gen) + Gli-1(n) +  !Delta-Gli-3(n) + !Gli-1_ß-catenin(n)  + !miR-let-7(c) +   !PDCD4(n) +  !p53Tetra(n)  +  !p73Tetra(n)  =  7 SNAIL(c) ","1,2,3,4,5    "]
["R2","SNAIL(gen) + Gli-3(n) + !Delta-Gli-3(n) + !Gli-1_ß-catenin(n)  +  !miR-let-7(c) +  !PDCD4(n) +  !p53Tetra(n)  +  !p73Tetra(n)  = 7 SNAIL(c)   ","1,2,3,4,5"]
["R3","SNAIL(gen) + 3   ILK*(pm) + !Gli-1_ß-catenin(n)  +  !miR-let-7(c) +  !PDCD4(n) +  !p53Tetra(n)  +  !p73Tetra(n)  =  6  SNAIL(c)  ","6,7,8,9 "]
["R4","SNAIL(gen) + KLF8(n) + !Gli-1_ß-catenin(n)  +  !miR-let-7(c) +  !PDCD4(n) +  !p53Tetra(n)  +  !p73Tetra(n)  = 6 SNAIL(c)    ",10]
["R5","SNAIL(gen) + ER*(nm) + !Gli-1_ß-catenin(n)  +  !miR-let-7(c) +   !PDCD4(n) +  !p53Tetra(n)  +  !p73Tetra(n)  = 6 SNAIL(c)    ",11]
["R6","SNAIL(gen) + EGFR*(pm) + !Gli-1_ß-catenin(n)  +  !miR-let-7(c) +   !PDCD4(n) +  !p53Tetra(n)  +  !p73Tetra(n)  = 6 SNAIL(c)    ",12]
["R7","CdhE(gen) +  CITED2(n) + !SNAIL(c) + !ZEB1/2(n) + !DeltaN-LEF1(n) +  !CTBP_Repressive_Complex(n)  + !ß-catenin_TCF4(n) + !KLF4(n) = 6 CdhE(c)    ","12,13,14,15, 16, 17"]
["R8 ","CdhE(gen) +  AP-2(n) +  !SNAIL(c) + !ZEB1/2(n) +   !DeltaN-LEF1(n) + !CTBP_Repressive_Complex(n) +  !ß-catenin_TCF4(n)  + !KLF4(n) +  !KLF8(n)    =  7 CdhE(c)    ","14, 18"]
["R9","CdhE(gen) + Prb(n)  + !SNAIL(c) + !ZEB1/2(n) + !DeltaN-LEF1(n) + !CTBP_Repressive_Complex(n) + !ß-catenin_TCF4(n) + !KLF4(n) +  !KLF8(n)  = 7 CdhE(c)    ","14, 18"]
["R10","CdhE(gen) + VDR*(n) + !SNAIL(c) + !ZEB1/2(n) + !DeltaN-LEF1(n) +  !CTBP_Repressive_Complex(n) +  !ß-catenin_TCF4(n) + !KLF4(n) +  !KLF8(n)  = 7 CdhE(c)      ","10, 13, 19, 20"]
["R11","CdhE(gen) + PDCD4(n) + !SNAIL(c) + !ZEB1/2(n) +   !DeltaN-LEF1(n) + !CTBP_Repressive_Complex(n) +  !ß-catenin_TCF4(n) + !KLF4(n)  +  !KLF8(n)  = 7 CdhE(c)     ",2]
["R12","CdhE(gen) + Oct4_Oct4(n)  + !SNAIL(c) + !ZEB1/2(n) + !DeltaN-LEF1(n) + !CTBP_Repressive_Complex(n) + !ß-catenin_TCF4(n) + !KLF4(n) +  !KLF8(n)    = 7 CdhE(c)    ",21]
["R13","CdhE(gen) +  HNF3(n)  + !SNAIL(c) + !ZEB1/2(n) + !DeltaN-LEF1(n) + !CTBP_Repressive_Complex(n) + !ß-catenin_TCF4(n) + !KLF4(n) +  !KLF8(n)    = 7 CdhE(c)    ","22,23,24,25"]
["R14","CdhE(c) + CKII(c) +  !CKIIP(c)  =  CdheP(Ser684,686,692)(c)   ","26,27,28"]
["R15","CdhE(c) +   GSK3beta(c) +  !AKT*(pm)  +   !p90RSK*(c) +   !p70S6K*(c)   =  2 CdhEP(Ser684,686,692)(c)  ","27,29,30,31,32, 33"]
["R16","CdhEP(Ser684,686,692)(c) + ß-catenin(c)  +  IQGAP1,3(c)  +   Caveolin(c)   + !ß-cateninP(Tyr654)(c) +  !alpha-cateninP(Tyr142)(c)  +   !Cdhe_Complex(AJ)   =   Cdhe_ß-catenin_IQGAP(pm) ","27,29,30, 31,32,34,35"]
["R17","Cdhe_ß-catenin_IQGAP(pm) + RhoA*(AJ) +  !IQGAP_CaMK(c) =  Cdhe_ß-catenin(pm)  ","7,29,31,32,  34,35"]
["R18","Cdhe_ß-catenin_IQGAP(pm)  +  RhoA*(AJ)  +  !IQGAP_CaMK(c) =  IQGAP1,3(pm) ","27,29,30, 31,34,35,36"]
["R19","Cdhe_ß-catenin(pm) + Caveolin(pm)   =  Cdhe_ß-catenin(cis)  ","37,38"]
["R20","3  PLC-gamma*(c)  =  Ca+2(c)   ",39]
["R21","Ca+2(c) = CaMK*(c)    ",40]
["R22","PhospolipaseD*(pm)  +  P-Choline(pm)  = LPA(c)   ",40]
["R23","CaModuline*(c)  =  GRFras(gef)    ",40]
["R24","IQGAP1,3(c)   +  CaModuline*(c)   = IQGAP_CaMK(c)   ",40]
["R25","Nectin-like(gen) +  TGFbeta(ec)  =  Nectin-like1/4(pm)  ","41,42"]
["R26","Nectin-like1/4(pm)  +  Afadin(c)   =  Nectin-like1/4_Afadin(cis) ","35,43"]
["R27","Nectin-like1/4_Afadin(cis)  +  Caveolin(pm)  =  Nectin-like1/4(trans) ","26,43"]
["R28","Nectin-like1/4(trans)  =    Nectin-like1/4(trans)_RAP1*(pm)","26,35"]
["R29","Nectin-like1/4(trans)  +  Cdhe_ß-catenin(cis) +   Ca+2(ec) =  2   Cdhe_ß-catenin(trans)   ",35]
["R30","Cdhe_ß-catenin(trans)  + Nectin-like1/4(trans)_RAP1*(pm)  +  p120ctn(c) +  !p120ctn* (c)  =   Cdhe_Complex(AJ)  ","37,43"]
["R31","Nectin-like1/4(trans)  +  ZO-1(c)   =  ZO-1(AJ) ","37,43"]
["R32","Nectin-like1/4(trans) +  FAK1(c)   =  FAK1P(Tyr397)(pm) ","43,44"]
["R33","Osteopontin(ec) + VNR(pm) +  Nectin-like1/4(trans)  =  2 Nectin-like1/4(trans)_RAP1*(pm)","43,45"]
["R34","Vitronectin(ec) + VNR(pm) +  Nectin-like1/4(trans)  =   Nectin-like1/4(trans)_RAP1*(pm)",26]
["R35","Cdhe_Complex(AJ) +  alpha-catenin(c)   =  (alpha-catenin)2(c)  ","27,46,47"]
["R36","(alpha-catenin)2(c) + EPLIN(c) + alpha-actininP(Tyr12)(pm) + Profilin(c) + jub(c) + !ARP2,3*(c) + !alpha-actininP(Tyr4,31)(pm) + !FascinP(c) + !jubP(c) = Bundled_Actin","24,48"]
["R36b","(alpha-catenin)2(c) + EPLIN(c) + alpha-actininP(Tyr12)(pm) + Fascin(c) + jub(c) + !ARP2,3*(c) + !alpha-actininP(Tyr4,31)(pm) + !FascinP(c) + !jubP(c) = Bundled_Actin","24,49"]
["R38","CdhE_Complex(AJ)  = c-Src*(AJ)  ","50,51"]
["R39","c-Src*(AJ) + PI3K(c)  = 2  CdhE_Complex(AJ)  ","37,50"]
["R40","CdhE_Complex(AJ)   +   2 c-Src*(pm)  =  ß-cateninP(Tyr654)(c)   ","37,50"]
["R41","c-Src*(AJ) +  PI3K*(c)  +  C3G(pm) =  VAV2(pm)  ",50]
["R42","c-Src*(AJ)  = C3G(pm)  ","38,50"]
["R43","VAV2(pm) =  RAC1*(AJ) ",52]
["R44","C3G(pm)  =  CDC42*(AJ)  ","50,51"]
["R45","RAC1*(pm) = IQGAP1,3(c) ",53]
["R46","Cdhe_ß-catenin_IQGAP(pm)  +  CaveolinP(Tyr14)(pm) +   !Cdhe_Complex(AJ)  +    !Nectin-like1/4(trans)_RAP1*(pm)  =  CdhE(endocythosis1) ","43,54,55,56"]
["R47","Cdhe_ß-catenin_IQGAP(pm)  +  clathrin(c)  +  ARF6*  +  dynamin(c)  +  Rab5* +  !Cdhe_Complex(AJ)   +  !Nectin-like1/4(trans)_RAP1*(pm)   =   CdhE(endocythosis2) ","56,57"]
["R48","CdhE(endocythosis1)  +   Hakai(c)  =   CdhE(catabolized1)  ",58]
["R49","CdhE(endocythosis2)  +   Hakai(c)  =   CdhE(catabolized2)  ",43]
["R50","CdhE(endocythosis1) +  Ral-A(c) +  Rab11 +  !Hakai(c)  =  CdhE(recycled1)   ","57,59"]
["R51","CdhE(endocythosis2) + Ral-A(c)  +  Rab11 +  !Hakai(c)  =  CdhE(recycled2)     ","57,59"]
["R52","RAS*(pm)  = RAL-A(c)   ","59,60,61"]
["R53","ERK1,2*(n)  =  C-EBPalpha,beta(n) ","22,23,62"]
["R54","ERK1,2*(n)   =  Hakai(c) ","60,63"]
["R55","TGFbeta(ec)  =  Hakai(c) ",40]
["R56","GATA1,2,3(n)  =  CDX1,2(n)   ","12,64,65,66"]
["R57","PTP(pest)(pm)  =  CDX1,2(n)    ",67]
["R58","C-EBPalpha,beta(n)  = CDX1,2(n)      ",68]
["R59","C-EBPalpha,beta(n)  =  HNF3(n)       ","23,69"]
["R60","beta1integrin(pm) +  HNF3(n)   =  SHH(ec)   ","23,62,70,71"]
["R61","C-EBPalpha,beta(n)  =   MMP8(ec)     ",72]
["R62","Caveolin(gen) +  glucose(ec) +    !EGFR*(pm)  =  Caveolin(c)     ","64,67"]
["R63","Caveolin(gen) +     CDX1,2(n) + !EGFR*(pm)  =  Caveolin(c)     ","73,74"]
["R64","Caveolin(gen) +   Fibronectin(ec) +  !EGFR*(pm)   = Caveolin(c)    ",75]
["R65","Caveolin(gen) +    CollagenI(ec)  + !EGFR*(pm)   =  Caveolin(c)    ","76,77"]
["R66","2  Fibronectin(ec) +  CaveolinP(Tyr14)(c)  = Fibronectin(endocyted_catabolized) ",78]
["R67","Occludin(c)  + Claudin(c)  +  ZO-1(c) +   Contactin(c) +   !SNAIL(c) +  !c-Met*(pm)  + !(alpha-catenin)2(c)  +  !alpha-catenin(c)  +  !TNFalpha(ec) +  !ROS + !c-Src*(pm) +  !FascinP(c)  + !Claudin-1(c) =  Tight_Junction(pm)  ","79,80,81"]
["R68","Occludin(gen)  +   TGFbeta(ec)  + !SNAIL(c)  +  !c-Met(pm) + !TNFalpha(ec)  =  Occludin(c)","82,83,84"]
["R69","Occludin(gen)  +   VDR*(n)  + !SNAIL(c)  +  !c-Met(pm) + !TNFalpha(ec)  = Occludin(c) ","85,86"]
["R70","Occludin(gen) +   PPARgamma*(n)  +  !SNAIL(c)  +  !c-Met(pm) + !TNFalpha(ec)  = Occludin(c) ",85]
["R71","Occludin(gen) +   ER*(n)  +  !SNAIL(c)  + !c-Met(pm) + !TNFalpha(ec)  =  Occludin(c)  ",87]
["R72","Claudin(gen) +   TGFbeta(ec)  +   6  !SNAIL(c)   =    0   Claudin(c)  ","81,87"]
["R73","Claudin(gen) +   TGFbeta(ec)  +  4   !SNAIL(c)   =    2  Claudin(c)  ","81,87"]
["R74","Claudin(gen) +   TGFbeta(ec)  +   2   !SNAIL(c)   =     4   Claudin(c)  ","81,87"]
["R75","Claudin(gen) +   TGFbeta(ec)  +   0  !SNAIL(c)   =    6   Claudin(c)  ","81,87"]
["R76","ZO-1(gen) +  Nectin1,4trans(pm)   =  ZO-1(c) ",88]
["R77","ZO-1(gen) +  PPARgamma*(n)   =  ZO-1(c) ","84,89"]
["R78","ZO-1(gen) +  VDR*(n)   =  ZO-1(c) ",86]
["R79","ZO-1(gen) +  TGFbeta(ec)   =  ZO-1(c)   ","81,83,87"]
["R80","Vinculin(gen)  +  VDR*(n)  = Vinculin(c)  ","81,90"]
["R81","JAM-A(gen) +   ER*(nm)  +  !SNAIL(c)   =  JAM-A(c) ","85,91"]
["R82","c-Met*(pm)  =  ZO-1P(c)  ","91,92"]
["R83","ZO-1P(c)  =   ZO-1P(n) ","86,93"]
["R84","ZO-1P(n)   =   MMP14(c) ",81]
["R85","Claudin-1(c)   +  ZO-1P(c)  =   Claudin-1(n) ",94]
["R86","PlakoglobinP(Tyr643)(c)  +  DSC(c) +  DSG(c)  + PNN(c) +  !PlakoglobinP(Tyr549)_alpha-catenin(c) +  !EGFR*(pm) + !c-Met*(pm)  =  Desmosomes(pm)  ",95]
["R87","Desmosomes(pm)  + MMP9(ec)  =  DSGshedding    ",96]
["R88","Desmosomes(pm)  +  ADAM17*(pm)  =  DSGshedding  ",97]
["R89","DSG(c)  + Caspase3*  =  apoptosis  ","98,99"]
["R90","Plakoglobin(gen)   +  SRF(n) +  HDAC1(n)  =  Plakoglobin(c) ",169170172173]
["R91","Plakoglobin(gen)   +  PPARgamma*(n) +  HDAC1(n)  =  Plakoglobin(c) ",95]
["R92","Plakoglobin(gen)   +  ER*(n) +  HDAC1(n)    =  Plakoglobin(c) ",100]
["R93","Plakoglobin(gen)   +  C-EBPalpha,beta(n) +  HDAC1(n)  =  Plakoglobin(c) ",100]
["R94","DSC(gen) + CDX1,2(n)  + !EGFR*(pm)  =  DSC(c)   ",171]
["R95","ER(gen) +   ß-catenin_TCF4(n)  =  ER(nm) ",101]
["R96","ER(gen) +   Alpha-actininP(Tyr4,31)(pm)  +  CaMK*(c)   =  ER(nm) ",48]
["R97","ER(nm) +   Estrogen(ec)  =  ER*(n)  "]
["R98","Plakoglobin(c) + p53Tetra(n) +   !PlakoglobinP(Tyr549)_alpha-catenin(c)  =  Plakoglobin(n) ","Assumed"]
["R99","PML(gen) + p53tetra(n) +  ß-catenin(n) +  Plakoglobin(n)  = PML(n) ",102]
["R100","ß-catenin_TCF4(n) + PML(n)  =  ß-catenin_TCF4_PML(n)   ",102]
["R101","ARF(gen) +   ß-catenin_TCF4_PML(n)  =  ARF(c)    ",102]
["R102","PTP(pm)  =  FER*(pm) ",75]
["R103","Plakoglobin(c) +  EGFR_Src*(pm)   =  PlakoglobinP(Tyr693,724,729) ",75]
["R104","Plakoglobin(c) +  c-Met_Src*(pm) =  PlakoglobinP(Tyr693,724,729) ",75]
["R105","Fyn*(pm) +   Plakoglobin(c)   = PlakoglobinP(Tyr549)(c)   ",75]
["R106","FER*(pm) + Plakoglobin(c)  =  PlakoglobinP(Tyr549)(c)   ",75103104]
["R107","c-Src*(AJ)  +  Plakoglobin(c)  =  PlakoglobinP(Tyr643)(c)   ",75103104]
["R108","PlakoglobinP(Tyr549)(c)  +  alpha-catenin(c)  =  PlakoglobinP(Tyr549)_alpha-catenin(c)  ",75103104]
["R109","Plakoglobin(n)  =  Bcl2(c)    ",105]
["R110","PTP1B(inactive)  + FER*(pm)   =  PTP1BP(Tyr152)(pm)   ",31106107108]
["R111","PTP1B(inactive)  + Cdhe_Complex(AJ)   =  PTP1BP(Tyr152)(pm)   ",31106107108]
["R112","alpha5(pm) +   beta1Integrin(pm)  =  alpha5beta1Integrin(pm)  "]
["R113","Fibronectin(ec)   +  alpha5beta1Integrin(pm) +  Caveolin(c) + 3  !FAK1P(Ser910,843)(pm)   =  Caveolin(pm) ",60]
["R114","Vitronectin(ec) +    VNR(pm)  +  Caveolin(c) +  3  !FAK1P(Ser910,843)(pm)   =  Caveolin(pm)   ",60109]
["R115","Caveolin(pm)  = beta1Integrin(pm) ",174]
["R116","ER*(n)   =   beta1Integrin(pm) ",175]
["R117","JAM-A(c)  =   beta1Integrin(pm) ",110]
["R118","Fibronectin(ec)   +  Beta1Integrin(pm)  +   alpha-actinin(c)  +  FAK1(c)  +   3   !FAK1P(Ser910,843)(pm) +   !PTP1BP(Tyr152)(pm)  =  FAK1P(Tyr397)(pm)   ",44111112113]
["R119","Beta1Integrin(pm) +   alpha-actinin(c)   +  FAK1(c)  +   3   !FAK1P(Ser910,843)(pm) +  !PTP1BP(Tyr152)(pm)    =  alpha-ActininP(Tyr12)(pm)   ","44,48,114"]
["R120","alpha-ActininP(Tyr12)(pm)  +  PTP1BP(Tyr152)(pm)   =   alpha-actinin(pm)   ",48]
["R121","Fibronectin(ec) + Beta1Integrin(pm) +  alpha-actinin(c)  +   FAK1(c)   +  p38MAPK*(c)  +  !PTP1BP(Tyr152)(pm)  =  FAK1P(Tyr397)(pm)  ",108115]
["R122","Fibronectin(ec)   + Beta1Integrin(pm) +  alpha-actinin(c) +  FAK1P(Tyr397)(pm) +  Grb2(pm)  =  RAS*(basal)   ",116117118]
["R123","RAS*(basal)  + PI3K*(c)   =  RAC1*(AJ)   ",176]
["R124","RAC1*(AJ)  +  2  !ERK1,2*(c)  = PAK*(basal)  ",177178]
["R125","RAC1*(llamelopodia)  +  2  !ERK1,2*(c)  = PAK*  ",119]
["R126","PAK*(basal)   =  LIMK1*  ",179]
["R127","2  !LIMK1* +  2   !LIMK2* =  cofilin(c)    ",180]
["R128","RhoA*(pm)  =  2   LIMK2*   ",193]
["R129","RhoA*(AJ)  =     LIMK2*   ",193]
["R130","Beta1Integrin(pm) +  alpha-actinin(c)  +  FAK1(c)  +  PIP_Complex  +  !PTP(pest)  +  mTORComplex1(c) +   !PTEN(c) +  !TSC2_TSC1(c)  =  FAK1P(Ser910,843)(pm) ",115]
["R131","Beta1Integrin(pm) +  alpha-actinin(c)  +  FAK1(c)   +  PIP_Complex  +    p70S6K*(c) +   !PTP(pest)(pm)  +    !PTEN(c)   =  FAK1P(Ser910,843)(pm)  ",115]
["R132","Beta1Integrin(pm) +    FAK1(c)   +   alpha-actinin(c)  +   3   ILK*(pm)   +  PIP_Complex  +  !PTEN(c)  +    !PTP(pest)(pm)  +  !SHP2(c)    =  FAK1P(Ser910,843)(pm) ",44]
["R133","Beta1Integrin(pm)  +   FAK1(c)  +  alpha-actinin(c)   +    EGFR*(pm)   +  PIP_Complex  +   !PTEN(c) +    !PTP(pest)(pm)  +  !SHP2(c)   =  3  FAK1P(Ser910,843)(pm)  ",44107120]
["R134","Beta1Integrin(pm)  +   FAK1(c) +   alpha-actinin(c)  +   GPCR*(pm)  +  PIP_Complex +  !PTEN(c)  +    !PTP(pest)(pm)  +  !SHP2(c) =  3  FAK1P(Ser910,843)(pm)   ",107]
[]
["R135","FAK1(c)  +  alpha-actinin(c)   +   2  Integrin_Scr*(pm) +   PIP_Complex +  !PTEN(c) +    !PTP(pest)(pm)  +  !SHP2(c)  = 3  FAK1P(Ser910,843)(pm)   ",44]
["R136","FAK1(c)  +   alpha-actinin(c)   +    3  ILK*(pm)  +  PIP_Complex  +  !PTEN(c) +    !PTP(pest)(pm)  +  !SHP2(c)  =   3   alpha-actininP(Tyr4,31)(pm)  ",44]
["R137","Beta1Integrin(pm) +    FAK1(c)  +  alpha-actinin(c)  +   EGFR*(pm)  + PIP_Complex +   !PTEN(c)   +    !PTP(pest)(pm)  +  !SHP2(c)  =  alpha-actininP(Tyr4,31)(pm)  ","44,48"]
["R138","Beta1Integrin(pm)  +   FAK1(c)  +  alpha-actinin(c)  +   GPCR*(pm)   + PIP_Complex  +  !PTEN(c)  +    !PTP(pest)(pm)  +  !SHP2(c)  =  alpha-actininP(Tyr4,31)(pm)  ",44]
["R139","FAK1(c)   +   alpha-actinin(c)   +   2  Integrin_Scr*(pm) +   PIP_Complex +  !PTEN(c) +   !PTP(pest)(pm)  +  !SHP2(c)   =  alpha-actininP(Tyr4,31)(pm) ",44]
["R140","3  FAK1P(Ser910,843)(pm)   =  3   PLC-gamma*(c)  ",121]
["R141","EGFR*(pm)  =  3  PLC-gamma*(c)  ",194]
["R142","EGFR_Src*(pm)  =  3  PLC-gamma*(c)  ",121]
["R143","FAK(gen) +  N-Myc(n) + 2   !p53Tetra(n)  =  FAK1(c) ",122]
["R144","CaModuline*(c)  +  !PTEN(c)    =   FAK1P(Ser910,843)(pm)  ",123]
["R145","3  FAK1P(Ser910,843)(pm) +   Grb2(pm)   =   RAS*(pm)    ",195196]
["R146","Fibronectin(ec)   +   alpha5beta1Integrin(pm)  +  ILK(c) =  ILK*(pm) ","6,7"]
["R147","ILK*(pm)  = Fibronectin(ec)   ","6,7,8,124"]
["R148","3  ILK*(pm) =  2  AKT*(c)  ",76125]
["R149","ERK1,2*(c ) +  !PTEN(c)  = GSK3betaP(inactive)  ",33]
["R150","3  ILK*(pm) + !PTEN(c)  =  GSK3betaP(inactive)  ",126127]
["R150bis","2  AKT*(pm) + !PTEN(c)  =  GSK3betaP(inactive) ",33]
["R151","3  ILK*(pm)  + PIP_Complex  =  Fibrillar_Complex ",128]
["R152","ß-catenin(c) + 3  ILK*(pm) + !PTEN(c) +   !VDR*(n) =  ß-catenin(n)  ","6,86,127"]
["R153","3  ILK*(pm)  =  RAS*(pm)  ",181]
["R154","ILK(gen) + Wnt1(ec)  =  3  ILK(c) ",129]
["R155","ILK(gen) + PML(n)   =  ILK(c) ",182183184]
["R156","ILK(gen) +  RAR*(nm)   =  ILK(c) ",182183184]
["R157","ILK(gen) + PI3K*(c)  =   ILK(c) ",130]
["R158","ILK(gen) +  Progastrin(ec) + ProgastrinR(pm)  =  3  ILK(c) ",131]
["R159","HGF(ec) + c-Met_ß-catenin(pm) + Caveolin(pm) = ß-cateninP(Tyr654)(c) ",132]
["R160","HGF(ec) + c-Met_ß-catenin(pm)  + Caveolin(pm)  =  ARF6* ",133]
["R161","HGF(ec) + c-Met_ß-catenin(pm) +  Caveolin(pm)  =  Fyn*(pm) ",31]
["R162","HGF(ec) + c-Met_ß-catenin(pm)  =  FER*(pm) ",31]
["R163","HGF(ec) + c-Met_ß-catenin(pm)  =  RAS*(pm) ",39]
["R164","HGF(ec) + c-Met_ß-catenin(pm)  =  PI3K*(c) ",39]
["R165","HGF(ec) + c-Met_ß-catenin(pm)  =  Ca+2(c) ",39]
["R166","HGF(ec) + c-Met_ß-catenin(pm)  =  PKC*(c) ",39]
["R167","HGF(ec) + c-Met_ß-catenin(pm)  =  3  FAK1P(Ser910,843)(pm) ",134135185]
["R168","3   FAK1P(Ser910,843)(pm)  =  3  NWASP(c) ",165166]
["R169","HGF(ec) + c-Met_ß-catenin(pm)  =  CDC42*(llamelopodia) ",167]
["R170","CDC42*(llamelopodia) +    NWASP(c)  =  ARP2,3*(c)   ",165168]
["R171","HGF(ec) + c-Met_ß-catenin(pm) + IQGAP_CaMK(c) +  APC(c) + PI3K*(c) +  !PTEN(c) = ASEF(GEF) ",136137138]
["R172","HGF(ec) + c-Met_ß-catenin(pm) + IQGAP_CaMK(c) +  APC(c) +  PI3K*(c) + c-Src*(pm) + !PTEN(c) = 2 ASEF(GEF) ",136137138]
["R173","HGF(ec) + c-Met_ß-catenin(pm) +  delta-APC(c)   =  2   ASEF(GEF) ",136137138]
["R174","RAC1(c) +  ASEF(GEF)  =  RAC1*(llamelopodia)  ",136137]
["R175","RAC1(c) +  2  ASEF(GEF)  =  2  RAC1*(llamelopodia)   ",136137]
["R176","RhoA(c) + PI3K*(AJ) + !p120GAP + !ARF6* = 2  RhoA*(AJ)  ",136137]
["R177","EGF(ec)  + ADAM17*(pm) + EGFR(pm) +  2  !Cdhe(Trans) =  EGFR*(pm) ",139140141142]
["R178","TGFalpha(ec)  + ADAM17*(pm) + EGFR(pm)  + 2  !Cdhe(Trans)  =  EGFR*(pm) ",139140141]
["R179","EGF(ec)  + ADAM17*(pm) + EGFR(pm) +  !Cdhe(Trans) =  EGFR*(pm) ",139140141]
["R180","TGFalpha(ec) + ADAM17*(pm) +EGFR(pm) + !Cdhe(Trans) = EGFR*(pm)   ",139140141]
["R181","EGF(ec)  + ADAM17*(pm) + EGFR(pm) +  0 !Cdhe(Trans) = 2 EGFR*(pm)  ",139140141]
["R182","TGFalpha(ec) + ADAM17*(pm) + EGFR(pm) + 0 !Cdhe(Trans)  = 2  EGFR*(pm) ",60]
["R183","EGFR*(pm) +  SHP2(c)  =  EGFR_Src*(pm)",143]
["R184","ERK1,2*(c)   =   CKIIP(c)  ",144]
["R185","EGFR_Src*(pm)  = RAB5* ",186]
["R186","EGFR_Src*(pm)  = ARF6*  ",145]
["R186bis","HGF(ec) + c-Met(pm)  =  RAB5*",58]
["R187","EGFR*(pm)  + C3g(pm) +  CRK  =  EGFR_RAP1*(pm) ",187]
["R188","EGFR_Src*(pm)  + Grb2(pm) +  !p120GAP(pm) +  SOCS3(c)  =  RAS*(pm) ",143]
["R189","RAS*(pm)  =  c-RAF*(c)  ","Cell Signalling Map"]
["R190","EGFR_RAP1*(pm)  = b-Raf(c)   ","Cell Signalling map"]
["R191","c-Raf*(c)  + b-Raf*(c)   = MEK1,2*(c)  ","Cell Signalling map"]
["R192","MEK1,2*(c)  = ERK1,2*(c)  ","Cell Signalling Map"]
["R193","EGFR*(pm)  +  Caveolin(pm)  = Fyn*(pm) ","Cell Signalling Map"]
["R194","Stat3P(n)  = SOCS3(c)  ",143]
["R195","RhoA(pm) +  c-GMP +   !ARF6* +  !EGFR_Src*(pm) = RhoA*(llamellopodia) ",133146]
["R196","RAC1(pm)  +  PI3K*(c)  +   EGFR_RAP1*(pm)  + !PTEN(c)  =  RAC1*(llamelopodia)    ",146]
["R197","CDC42(pm)  +    EGFR_RAP1*(pm)  =  CDC42*(llamelopodia)   ",146]
["R198","EGFR_Src*(pm) + PI3K*(c)  + APC(c) + !PTEN(c)  =  2 ASEF(GEF)   ",136137]
["R199","c-GMP  =  MYOII(assembled)   ",207]
["R200","EGFR_RAP1*(pm)  = MYOII(disassembled) ","208. 209"]
["R201","Profilin(c)  +   RAC1*(llamelopodia)  = Profilin*(c) ",188]
["R202","Profilin(c)  +   CDC42*(llamelopodia)  = Profilin*(c) ",188189]
["R203","Profilin*(c) + ARP2,3*(c) +  !cofilin(c) +  !Profilin(c)  = Branched_Actin_Polimerization   ",188]
["R204","Fascin(c)   + CaMK*(c)  =  FascinP(c)   ",147148]
["R205","Fascin(c)   +  PKC*(c)  = FascinP(c)   ",147148]
["R206","Fascin(c)   + 3  ILK*(pm)  =  FascinP(c)    ",48149]
["R207","JUB(c)  +   LATS2*(c)  =  JUBP(c)   ",190]
["R208","JUB(c)  +  AuroraA*(c)  = JUBP(c)   ",191]
["R209","JUBP(c)  =  mitosis_commitment    ",191]
["R210","JUB(c)  + Dsh*(c)  =   JUBcatabolized  ",150]
["R211","Profilin(gen)   =  3 Profilin(c)     ",90]
["R212","Profilin(gen)   +  !RAC1*(pm)  =  Profilin(c)   ","Cell Signalling map"]
["R213","Fascin(gen)   + CREB(n)  +  !GR*(n)   =  Fascin(c)   ",149150]
["R214","Fascin(gen)   +  ILK*(pm)   +   !GR*(n)   =  Fascin(c)   ",149150]
["R215","alpha-actinin(c)  +  EGFR_Src*(pm)  = alpha-actininP(Tyr4,31)(c)    ",48]
["R216","alpha-actinin(c)  +  CaMK*(c)   = alpha-actininP(Tyr4,31)(c)      ",48]
["R217","CdhE_ß-catenin(pm) + RAC1(c) +  2 !RAS*(pm) =  RAC1*(AJ)    ",192]
["R218","Frz(gen) +  CdhP(c)  =   Frz3(pm)      ","197,198,199,200,"]
[null,null,201202203]
["R219","GR(c) +  Stat3P(c)  = GR*(n)    ",204]
["R220","CXCR4*(pm)  = CXCR_Src*(pm)   ","Cell Signalling map"]
["R221","CXCR_Src*(pm)  =  FAK1P(Ser910,843)(pm)   ","Cell Signalling map"]
["R222","CXCR_Src*(pm) +  Grb2(pm) +  !p120gap(pm) +  SOCS3(c)  =  RAS*(pm) ",60146]
["R223","LPA(ec)  + GPCR(pm)  = GPCR*(pm)  ","Cell Signalling map"]
["R224","Ca+2(c)  +   MyosinII(A+B)   =  contraction  ","Cell Signalling map"]
["R225","EGFR*(pm)  =  ADAM17*(pm)  ",75103104]
["R226","Cdhe_ß-catenin(trans)  =  weak_AJ   ",151]
["R227","Cdhe_Complex(AJ)  +   Bundled_Actin   =  strong_AJ   ",151]
["R228","CdhE_ß-catenin(pm) + Tight_Junction(pm) + Desmosomes(pm) +  !CdhEshedding + !DSGshedding + !Cdhe(recycled1) + !Cdhe(recycled2)   =  Super_Adhesive_Phenotype       "]
["R229","MMP14(c) +   IQGAP1,3(c)  +    Sec3,8(c)  =  MMP14(ec)  ",138]
["R230","MMP9(c)  +    IQGAP1,3(c)   +  Sec3,8(c)   =  MMP9(ec)  ",138]
["R231","Branched_Polymerized_Actin  +  alpha-actininP(Tyr4,31)(pm)  +   MMP14(ec) +  MMP9(ec)  =  Motile_Phenotype  ",48]
["R232","3  FAK1P(Ser910,843)(pm)  +  Fibrillar_Complex  =  Motility(+)  ",107]
["R233","ß-catenin(c)  + CKIIP(c) + !ICAT(n) + !RAR*(nm)  + !NLK(c)  =  ß-catenin(n)  ",152153]
["R234","CKIIP(c)  + alpha-catenin(c)   = alpha-cateninP(Ser641)  "]
["R235","ß-catenin(c)  + ERK1,2*(c) +  !ICAT(n)  + !RAR*(nm)  +  !NLK(c)  =  ß-catenin(n)  ",86]
["R236","ß-cateninP(Tyr654)(c) +  !ICAT(n)  + !RAR*(nm)  +  !NLK(c)  =  ß-catenin(n)  ",86153]
["R237","ß-cateninP(Tyr142)(c)   + Bcl9(n)  +  !ICAT(n)  + !RAR*(nm)  +  !NLK(c)   =  ß-catenin(n)  ",154]
["R238","ß-cateninP(Tyr489)(c)  +  !ICAT(n)  + !RAR*(nm)  +  !NLK(c)  =  ß-catenin(n)  ",86153]
["R239","!ß-cateninP(Tyr142)(c)  +  !Bcl9(n)   =  alpha-catenin(n)  ",154]
["R240","ß-catenin(n)  +  TCF4(n)  +  !PTK6(n)  +  !CTBP(n) +  !Groucho(n)  +  !alpha-catenin(n)   =  ß-catenin_TCF4(n) ",155158]
["R241","Wnt9b/6(ec) +  !p53Tetra(n)  =  PTK6P(inactive)  ",155158]
["R242","Survivin(gen) +  ß-catenin_TCF4(n) + 2 !RUNX3_ß-catenin_TCF4(n) +    !CDHE_ß-catenin(trans) +  !Caveolin(pm) +  !TCF4_CTBP_HDAC1(n) +  !TCF4_Groucho_HDAC1(n)  +  !PTEN(c) + !ß-catenin_TCF4_Plakoglobin(n)   =  Survivin(c)    ",156]
["R243","Survivin(gen) +   ß-catenin_FL-TCF1(n)  +    !CDHE_ß-catenin(trans) +  !Caveolin(pm) +   !dn-TCF1E(n)  +  !FL-TCF1_CTBP_HDAC1(n) +   !FL-TCF1_Groucho_HDAC1(n)  +  !PTEN(c)  =  Survivin(c)    ",156]
["R244","MMP7(gen) +  ß-catenin_TCF4(n) + 2 !RUNX3_ß-catenin_TCF4(n) +  CKII(c) +  !CDHE_ß-catenin(trans) +  !Caveolin(pm) +  !TCF4_CTBP_HDAC1(n) +  !TCF4_Groucho_HDAC1(n) +    !dn-TCF1E(n)  +  ß-catenin_FL-TCF1(n) +   !FL-TCF1_CTBP_HDAC1(n) +   !FL-TCF1_Groucho_HDAC1(n)  +  !PTEN(c)   = MMP7(ec)     "]
["R245","Plakoglobin(n) + ß-catenin_TCF4(n)  = ß-catenin_TCF4_Plakoglobin(n)  ",105]
["R246","Claudin-1(n)  =  MMP9(c)    ",94157]
["R246bis","3 ILK*(pm)   =  MMP9(c)  ",8]
["R247","PTK6(c)  +  Groucho(c) +  !Wnt9b/6(ec)   =  PTK6(n) ",155158]
["R248","PTK6(c)  +  Groucho(c)  +  !Wnt9b/6(ec)  =   Groucho(n) ",155158]
["R249","CKIIP(c)  +  alpha-catenin(c)   =  alpha-cateninP(Ser641)  ",144]
["R250","IGF1R*(pm)  +   2   !p70S6k*(c)    =   2  PI3K*(c)  ",159]
["R251","FAK1P(Tyr397)(pm)  +   !ERK1,2*(c)  +  !IGF1R*(pm)  =    2   PI3K*(AJ) ",160]
["R252","PI3K*(AJ) =  RAC1*(AJ)   ",161]
["R253","RAC1*(AJ)   +  VAV2(pm) = CDC42*(AJ) ","50,51"]
["R254","HGF(ec)  +  c-Met_ß-catenin(pm) =  FER*(pm) ",31]
["R255","EGFR*(pm) + Caveolin(pm)  =  CaveolinP(Tyr14)(pm)  ",162]
["R256","c-Src*(pm) + Caveolin(pm)  =  CaveolinP(Tyr14)(pm)  ",162]
["R257","PI3K*(c)  +  !p120GAP(pm) +  !ARF6*(pm) =  2 RhoA*(llamelopodia)",160]
["R258","HGF(ec) + c-Met(pm) + C3G(pm) + CRK = c-Met_RAP1*(pm)  ",163]
["R259","ß-catenin(c) +  GSK3beta(c) + Axin1/2(c) +  APC(c) +  !delta-APC(c)  +  !CKIIP(c)  +  !Dsh*(c) +  !AKT*(c) + !ERK1,2*(c)  +  !p90(RSK*)(c) + !GPCR*(pm) +  !PKC*(c)  =  ß-catenin(catabolized)  ",33164]
["R260","3  ILK*(pm)  =   ZEB1/2(n)",3]

{"sheet":"References","index":2,"n_rows":214,"n_cols":1,"rows_kept":214,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
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