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["Subsystem","Module","Metaoblite","Size","Reference","Note"]
["tRNA charging","b0194","L-Prolyl-tRNA(Pro)",1,"[1]"]
["tRNA charging","b0526","L-Cysteinyl-tRNA(Cys)",1,"[1]"]
["tRNA charging","b0642","L-Leucyl-tRNA(Leu)",1,"[1]"]
["tRNA charging","b0680","L-Glutaminyl-tRNA(Gln)",1,"[1]"]
["tRNA charging","b0893","L-Seryl-tRNA(Ser)",1,"[1]"]
["tRNA charging","b0930","L-Asparaginyl-tRNA(Asn)",1,"[1]"]
["tRNA charging","b1637","L-Tyrosyl-tRNA(Tyr)",1,"[1]"]
["tRNA charging","b1719","L-Threonyl-tRNA(Thr)",1,"[1]"]
["tRNA charging","b1866","L-Aspartyl-tRNA(Asp)",1,"[1]"]
["tRNA charging","b1876","L-Arginyl-tRNA(Arg)",1,"[1]"]
["tRNA charging","b2514","L-Histidyl-tRNA(His)",1,"[1]"]
["tRNA charging","b3384","L-Tryptophanyl-tRNA(Trp)",1,"[1]"]
["tRNA charging","b3560","Glycyl-tRNA(Gly)",1,"[1]"]
["tRNA charging","b4258","L-Valyl-tRNA(Val)",1,"[1]"]
["tRNA charging","b1713,b1714","L-Phenylalanyl-tRNA(Phe)",2,"[1]"]
["tRNA charging","b2114,b3288","L-Methionyl-tRNA (Met); N-Formylmethionyl-tRNA",2,"[1]"]
["Cofactor and Prosthetic Group Biosynthesis","b0025","FMN; FAD",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b0174","Undecaprenyl diphosphate",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b0417","Thiamine diphosphate",1,"[3]"]
["Cofactor and Prosthetic Group Biosynthesis","b0420","Glyceraldehyde 3-phosphate",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b0583","(2,3-Dihydroxybenzoyl)adenylate",1,"[4]","*"]
["Cofactor and Prosthetic Group Biosynthesis","b1740","Nicotinamide adenine dinucleotide",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b2153","2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b2315","Dihydropteroate",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b2615","Nicotinamide adenine dinucleotide phosphate",1,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b3650","Guanosine 3',5'-bis(diphosphate)",1,"[5]"]
["Cofactor and Prosthetic Group Biosynthesis","b3835","2-Octaprenylphenol",1,"[6]","*"]
["Cofactor and Prosthetic Group Biosynthesis","b0029,b2515","Isopentenyl diphosphate; Dimethylallyl diphosphate",2,"[7]"]
["Cofactor and Prosthetic Group Biosynthesis","b0173,b2747","2-C-methyl-D-erythritol 4-phosphate",2,"[8]"]
["Cofactor and Prosthetic Group Biosynthesis","b0369,b3805","Uroporphyrinogen III",2,"[9]"]
["Cofactor and Prosthetic Group Biosynthesis","b0415,b1662","6,7-Dimethyl-8-(1-D-ribityl)lumazine; 3,4-dihydroxy-2-butanone 4-phosphate",2,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b0414,b1277","4-(1-D-Ribitylamino)-5-aminouracil",2,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b1210,b2400","L-Glutamyl-tRNA(Glu)",2,"[1]"]
["Cofactor and Prosthetic Group Biosynthesis","b3634,b3639","Pantetheine 4'-phosphate; Dephospho-CoA",2,"[2]"]
["Cofactor and Prosthetic Group Biosynthesis","b0475,b3850","Heme",2,"[10]"]
["Nucleotide Salavage Pathway","b0474","AMP; ADP; IDP; etc",1,"[2]"]
["Nucleotide Salavage Pathway","b0171","UMP; UDP; dUMP; dUDP",1,"[2]"]
["Nucleotide Salavage Pathway","b1098","dtmp;dtdp",1,"[2]"]
["Nucleotide Salavage Pathway","b3648","GMP; ATP; dGMP",1,"[2]"]
["Nucleotide Salavage Pathway","b2234,b2235","Reduced thioredoxin; Oxidized thioredoxin",2,"[2]"]
["Cell Envelope Biosynthesis","b2533","dsRNA",1,"[12]"]
["Cell Envelope Biosynthesis","b3729","D-Glucosamine 6-phosphate",1,"[2]"]
["Cell Envelope Biosynthesis","b3730","N-Acetyl-D-glucosamine 1-phosphate; UDP-N-acetyl-D-glucosamine; D-Glucosamine 1-phosphate",1,"[2]"]
["Cell Envelope Biosynthesis","b0085,b0088","UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate",2,"[2]"]
["Cell Envelope Biosynthesis","b0087,b0090","Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine; Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-ala-D-glu-meso-2,6-diaminopimeloyl-D-ala-D-ala",2,"[2]"]
["Cell Envelope Biosynthesis","b3189,b3972","UDP-N-acetyl-D-glucosamine; UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine",2,"[2]"]
["Cell Envelope Biosynthesis","b0954,b1093,b2323","short-chain unsaturated acyl-ACP; short and long chain saturated and unsaturated β-ketoacyl-ACPs",3,"[2, 11]"]
["Cell Envelope Biosynthesis","b1093,b1288,b2323","short-chain unsaturated acyl-ACP; short and long chain saturated and unsaturated β-ketoacyl-ACPs",3,"[2, 11]"]
[" Threonine and Lysine Metabolism","b2472","LL-2,6-Diaminoheptanedioate",1,"[2]"]
[" Threonine and Lysine Metabolism","b3433","4-Phospho-L-aspartate; L-Aspartate 4-semialdehyde",1,"[2]"]
[" Threonine and Lysine Metabolism","b0031,b0166","2,3-Dihydrodipicolinate; 2,3,4,5-Tetrahydrodipicolinate",2,"[2]"]
[" Threonine and Lysine Metabolism","b0031,b2478","2,3-Dihydrodipicolinate; L-Aspartate 4-semialdehyde",2,"[2]"]
["Lipopolysaccharide biosynthesis/recycling","b1215","3-Deoxy-D-manno-octulosonate 8-phosphate",1,"[2]"]
["Lipopolysaccharide biosynthesis/recycling","b3793","Undecaprenyl diphosphate",1,"[2]","*"]
["Lipopolysaccharide biosynthesis/recycling","b0096, b0181,b1094","UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine",3,"[2]"]
["Lipopolysaccharide biosynthesis/recycling","b0096,b0179,b0182,b0524,b0915","LipidA",5,"[15]"]
["Glycerophospholipid Metabolism","b1912","Phosphatidylglycerophosphate",1,"[2]"]
["Glycerophospholipid Metabolism","b3018","acyl carrier protein",1,"[2]"]
["Glycerophospholipid Metabolism","b4041","Glycerol 3-phosphate",1,"[2]"]
["Glycerophospholipid Metabolism","b2585,b4160","phosphatidylserine; phosphatidylethanolamine",2,"[2]"]
["Glycolysis/Gluconeogenesis","b1779","Glyceraldehyde 3-phosphate; 3-Phospho-D-glyceroyl phosphate",1,"[2]"]
["Glycolysis/Gluconeogenesis","b2779","D-Glycerate 2-phosphate; Phosphoenolpyruvate",1,"[2]"]
["Glycolysis/Gluconeogenesis","b2926","3-Phospho-D-glycerate; 3-Phospho-D-glyceroyl phosphate",1,"[2]"]
["Purine and Pyrimidine Biosynthesis","b1131","N6-(1,2-Dicarboxyethyl)-AMP",1,"[2]","*"]
["Purine and Pyrimidine Biosynthesis","b2780","CTP",1,"[2]"]
["Histidine","b1207","5-Phospho-alpha-D-ribose 1-diphosphate; alpha-D-Ribose 5-phosphate",1,"[2]"]
["Methionine Metabolism","b2942","S-Adenosyl-L-methionine",1,"[2]"]
["Folate Metabolism","b0529","5,10-Methenyltetrahydrofolate",1,"[2]"]
["Alternate Carbon Metabolism","b4084","D-Allose",1,"[13]"]
["Alternate Carbon Metabolism","b3608","Dihydroxyacetone phosphate;Glycerol 3-phosphate",1,"[2]"]
["Membrane Lipid Metabolism","b0185,b2316,b3255,b3256","Malonyl-CoA",4,"[2]"]
["Unassigned","b0657","lipoprotein",1,"[14]"]
[]
[]
[]
["Note: "]
["* These four genes were considered as non-essential genes in PEC(Profiling of E.coli Chromosome) (http://www.shigen.nig.ac.jp/ecoli/pec/about.jsp). "]
["So compared with other functional modules, their confidence may not be that high. "]
[]
["Reference: "]
["[1]Aminoacyl-tRNA synthesis and translational quality control."]
["[2] Metabolite essentiality elucidates robustness of Escherichia coli metabolism."]
["[3] The Riboswitch Regulates a Thiamine Pyrophosphate ABC Transporter of the Oral Spirochete Treponema denticola."]
["[4] Genome-scale gene/reaction essentiality and synthetic lethality analysis."]
["[5] Role of spo T-dependent ppGpp accumulation in the survival of light-exposed starved bacteria. "]
["[6] Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis."]
["[7] Engineering a mevalonate pathway in Escherichia coli for production of terpenoids."]
["[8] Construction and characterization of Escherichia coli disruptants defective in the yaeM gene."]
["[9] Biosynthesis of the pigments of life: formation of the macrocycle."]
["[10] Abortive assembly of succinate-ubiquinone reductase (complex II) in a ferrochelatase-deficient mutant of Escherichia coli."]
["[11] EcoCyc: a comprehensive database of Escherichia coli biology."]
["[12] Lethal double-stranded RNA processing activity of ribonuclease III in the absence of SuhB protein of Escherichia coli."]
["[13] The D-allose operon of Escherichia coli K-12."]
["[14] Lipoprotein of Gram-negative bacteria is essential for growth and division."]
["[15] Antibacterial Agents That Inhibit Lipid A Biosynthesis. "]

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