SUPPLEMENTARY MATERIAL
Identification of components of novel NAD-dependent metabolic systems and prediction of their biochemical functions
Robson F. de Souza and L. Aravind*,
* Address for correspondence: L. Aravind (aravind@mail.nih.gov)
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

ABSTRACT
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous cofactor participating in numerous redox reactions. It is also an important substrate for regulatory modifications of proteins and nucleic acids via the addition ADP-ribose moieties or removal of acyl groups by transfer to ADP-ribose. In this study, we use in-depth sequence, structure and genomic context analysis to uncover new enzymes and substrate-binding proteins in NAD-utilizing metabolic and macromolecular modification systems. We show that Escherichia coli YbiA and related families of domains from diverse bacteria, viruses and eukaryotes are previously unrecognized components of NAD-utilizing systems that probably operate on ADP ribose derivatives. Using contextual analysis we show that some of these proteins potentially act in the context of RNA repair, where NAD is used to remove 2'-3' cyclic phosphodiester linkages. Likewise, we show that another family of YbiA-related enzymes is likely to comprise a novel NAD-dependent ADP-ribosylation system for proteins, in conjunction with a previously unrecognized ADP-ribosyltransferase. A similar ADP-ribosyltransferase is also coupled with MACRO or ADP-ribosylglycohydrolase domain proteins in other related systems, suggesting that all these novel systems are likely to comprise pairs of ADP-ribosylation and ribosylglycohydrolase enzymes analogous to the DraG-DraT system that regulates the nitrogenase in nitrogen-fixing bacteria. We present evidence that some of these systems are likely to regulate certain restriction modification systems through ADP-ribosylation in bacteria. The ADP-ribosyltransferases found in this system also through light on the evolution of this fold and the origin of the eukaryotic polyADP-ribosyltransferases. We also identify a novel biosynthetic pathway that might be involved in the synthesis of a novel NMN/NAD-like compound in conjunction with an asparagine synthetase and AMPylating peptide ligase. We use the data derived from this analysis to understand the origin and early evolutionary trajectories of key NAD-utilizing enzymes and present targets for future biochemical investigations.

### Contents

- Phyletic distribution, domain architectures and gene neighborhoods of various NAD+ related genes
  - The NADA domain
    - Phyletic patterns and domain architectures for all NADA homologs [sortable HTML table]
    - Gene neighborhoods of the YbiA family [svg file with links]
    - Gene neighborhoods of the BC4488 family [svg file with links]
    - Multiple Sequence Alignment of the NADA family
  - Proteins of the ADP-ribosyl transferase fold
    - BC4486 ART family
      - Phyletic patterns, domain architectures and gene neighborhoods [svg file with links]
      - Multiple Sequence Alignment of the BC4486 family
    - KptA/Tpt1 tRNA 2'-phosphotransferase
      - Phyletic patterns, domain architectures and gene neighborhoods [svg file with links]
      - Multiple Sequence Alignment
    - NEURL4-like ARTs
      - Domain architectures and organism's classification
      - Multiple Sequence Alignment
    - Polymorphic toxins
      - Phyletic patterns, domain architectures and gene neighborhoods [svg file with links]
      - Multiple Sequence Alignment
  - Second nadE paralog and associated acyl-adenylating enzyme
    - Phyletic patterns and domain architectures as [sortable HTML table] or [SVG file with links]
  - Other related enzymes
    - ARGA family
      - Phyletic patterns, domain architectures and gene neighborhoods [svg file with links]
      - Multiple Sequence Alignment
    - NUE family
      - Phyletic patterns, domain architectures and gene neighborhoods [svg file with links]
      - Multiple Sequence Alignment
    - Multiple sequence alignment of the RNxxxH domain
    - Phylogenetic tree of the sirtuins: [image] or [FigTree Nexus file]
  - Supplementary table S1: organism identifiers used in this work
  - Supplementary table S2: sequence accession numbers

Multiple Sequence Alignment of the NADA family

    #==== BC4488 family
    ALIGN                                -    ---EEEE------------------------------------------------HHHHHHHHH-EE--E-------------------------HHHHH------------------------------------------EEEEE-------------HHHHHHHHHHHHH------------------------------HHHHHHHHH--------H-------------------HHHHH-----------------------------------HHHHHHHHHH---------
    HMM                                  -    --EEEEEE-----------EEE-------------------------------EEEEEEEEEEEEEE--EE----------------------HHHHHHH------------------------------------------EEEEEE----------HHHHHHHHHHHHHHHH-----------------------------HHHHHHHH----------EEEEEE----------------HH-----------------------------------HHHHHHHHHH----HHHH-
    FREQ                                 -    --EEEE-------------------------------------------------EEEEHHEEE--E--EE-----------------------HHHHHH-------HHHHHHH-----------------------------EEEEE------------HHHHHHHHHHHHHHH---------------------------HHHHHHHHHH--------HHH-----------------HHHHH-----------------------------------HHHHHHHHHHH---HHHH-
    PSSM                                 -    -----E---------------------------------------------------EE--HE-------------------------------HHHHH---------------------------------------------EEE--------------HHHHHHHHHHHHHH---------------------------HHHHHHHHHH----------EEE-------------------H-----------------------------------HHHHHHHHH----------
    FINAL                                -    --EEEEE-------------E---------------------------------EEEEEEEEEEEEE--EE----------------------HHHHHHH---------HHHH-----------------------------EEEEEE------------HHHHHHHHHHHHHH----------------------------HHHHHHHHHH----------EEEEE--------------HHHH-----------------------------------HHHHHHHHHH----HHHH-
                                                                    #--                                  #      #  --                                         --                                                  -   -     -                          -                      #            -
    ROSINTL182_09631_Rint_240147581      49   EKALEVSSKSE----VRVGKEIGAFS------LEL-DG------------------IFLENVFQAAK--QY-----------------ENGGPYLDLLNV-------SPKQAKRDERHCN-------------------SGKLVGFVRNDEI---WTLEPKTAFYDYIYISALIK--------------------------FNGYDLNISEY--------QWFTDIEFNP-------QKSINCQA-----------------------------------RAVAIYVALQKTALFNSLK  196  240147581  bacteria>firmicutes
    ROI_18700_Rint_291535823             49   EKALEVSSKSE----VRVGKEIGAFS------LEL-DG------------------IFLENVFQAAK--QY-----------------ENGGPYLDLLNV-------SPKQAKRDERHCN-------------------SGKLVGFVRNDEI---WTLEPKTAFYDYIYISALIK--------------------------FNGYDLNISEY--------QWFTDIEFNP-------QKSINCQA-----------------------------------RAGSDWIGRW---------  185  291535823  bacteria>firmicutes
    Sca_2305_Scar_224477787              53   DKLLEVSSKSE----KSIGVKASAFN----LKISTVKG----------------HHLSVEQIFQSSK--VY-----------------KKAGNQNYLLEEG-----YNSKEMKQKLREIDK------------------DDYMIKYSSFHQD---FPLEPKTLFYNWIYINALNQ--------------------------NEEVAKEILKY--------EAFTDIEFNP-------KRSFNCQA-----------------------------------EACAIYVSLVKQKNLDEAL  208  224477787  bacteria>firmicutes
    pIL105p2_Llac_60461911               54   KKVLEISTKSP----TDLGVELSAFN----LKIQTKQ----------------EIYFTVESAFQSSK--VF-----------------ENGGPYDDLLLK-------GSREAKKDIRLKS-------------------SGKVIGFKYLNRE---FPSEPKTFFYNWLYVNALDK--------------------------NKKLSKELLSY--------DSFTDIEFNP-------EKSINCQA-----------------------------------EAAALYVSLSHKKLLTTAL  206  60461911   bacteria>firmicutes
    HMPREF9383_1770_Ssan_325694076       58   LKVLEVSTASE----EEFGKECSAFN----LQLTLRNG----------------SKYSVESLFQSSK--VF----------------KNYGRVNQDLDL--------DAKAVKRQVRSIEV------------------NDKLIEFDFLGVK---FPLLPRTYFYNWLYVNALFQ--------------------------NTELSNFILQY--------DAFTDINFNP-------NKSINCQA-----------------------------------EACSIFLYLAKNSLLNDSI  211  325694076  bacteria>firmicutes
    SSA_1883_Ssan_125718681              50   KKILEVSSKSI----DQVGRAASAFN----LKVTLKSG----------------KVYSVEQIFQGSK--VF----------------KKNGSQLKLLDSM-------TSKELKKIVGKLHQ------------------VDKLVEFESFGQH---FPLEPQTFFYNWLYINSLNQ--------------------------HKSLANQIIKY--------DAFTDIEFNP-------EKSKNCQA-----------------------------------EACSIYIFLYKSGLLDFAL  204  125718681  bacteria>firmicutes
    HMPREF9382_1113_Ssan_325690155       58   LKVLEVSTASE----EEFGKECSAFN----LQLTLRNG----------------NKYSVESLFQSSK--VF----------------KNYGRVNQDLDL--------DAKAVKRQVRSIEV------------------NDKLIEFDFLGVK---FPLLPRTYFYNWLYVNALFQ--------------------------NTELSNFILQY--------DAFTDINFNP-------NKSINCQA-----------------------------------EACSIFLYLAKNSLLNDSI  211  325690155  bacteria>firmicutes
    CBFG_01593_Cbac_239627871            60   ANILEISSKST----SALGVSLSAFN----LNIQTAK-----------------RAFSVECAFQSSK--VF-----------------ESGGPYTDLLDR-------SSIEAKKDPRLHD-------------------SGKLIAFQYFNVK---FPLEPKDYFYNWLYINALKL--------------------------NTELTSEIITY--------DSFSDIEFNP-------QKSINCQA-----------------------------------KAAAIFVSLSNQHLIEEAL  211  239627871  bacteria>firmicutes
    bcere0015_42140_Bcer_229129773       46   ESVLEVSSKSE----SDLGRALSAFN----LKIELKNG----------------KNFSVENAFQASK--VF-----------------EFGGPFLDLLYC-------TAKEAKKDVRLKN-------------------SGNLISFRYFNRE---WPLCPKTAFYDWLYINALAR--------------------------QQKLGSCVLEY--------SAFSDIEFNP-------KKSINCQA-----------------------------------RALALYVSLHKADKLQYVL  198  229129773  bacteria>firmicutes
    BC4488_Bcer_30022569                 32   ESVLEVSSKSE----SDLGRALSAFN----LKIELKNG----------------KNFSVENAFQASK--VF-----------------EFGGPFLDLLYC-------TAKEAKKDVRLKN-------------------SGNLISFRYFNRE---WPLCPKTAFYDWLYINALAR--------------------------QQKLGSCVLEY--------SAFSDIEFNP-------KKSINCQA-----------------------------------RALALYVSLHKADKLQYVL  184  30022569   bacteria>firmicutes
    Ilyop_1055_Ipol_310778851            52   ANILEISSKSL----ENLGIKLSAFN----LMIQTKKG----------------KAFSVECAFQGSK--VF-----------------KKGGPYIDLFHK-------TSREAKKDPRIKN-------------------SGPLVKFEYNKNE---WSLEPKTFFYDWLYINSLYR--------------------------KNELAQEIIKY--------DSFTDIEFNP-------EKSINCQA-----------------------------------RAAALFVLLKKLNIIDNAM  204  310778851  bacteria>fusobacteria
    OA238_4610_Oant_254453984            34   HPILEISTKSL----VEVGRRLSAFN----LKIDV-NG----------------TLKSLESVYQSSK--VF-----------------AHSGQHEHLMDL-------EPFMAKREVHSLG-------------------QGPIVAFRLLGEE---FPTEPKNAFYDWLYLKAITP--------------------------HEEWIKKNLHY--------AAYSDIEFNP-------SKSINCQG-----------------------------------RAVAEFHALSLRNSTMDCV  185  254453984  bacteria>proteobacteria>alphaproteobacteria
    ED21_31874_Esp._149186578            34   EKILEISSKSL----EDLGVRSSAFN----LKWLSSVA---------------NFPISVECAFQGSK--VF-----------------LNGGPFTDLYEA-------RPIDAKRDVRLRS-------------------SGNLKAFDFDGGN---WPIEPQTAFYDWLYISALRE--------------------------NPEIADAILSF--------DGFTDIEFNP-------KKSINCQA-----------------------------------YSAALFCSLYKQGMVDEVL  187  149186578  bacteria>proteobacteria>alphaproteobacteria
    CAP2UW1_1710_CAcc_257093308          52   AHILEISSKSE----DPLGVKLSAFN----LPFVMPNG----------------LRTTVENAFQSGK--VF-----------------RHGGPYLDLLNK-------TPREAKKDSRLSG-------------------SGDLVGFRLDGED---WPTRPLTAFYDWIYLSALKQ--------------------------SPALAEQLLRF--------DGFTDIEFNP-------ERSLNCQA-----------------------------------ASAALFVALTKRGEIDAAT  204  257093308  bacteria>proteobacteria>betaproteobacteria
    GBP346_A3087_Bpse_237813318          23   NDLLEISSKSP----NPDGVALSAFN----LKFTTLKY---------------NRTFSVEIAFQASK--VF-----------------EHGGPYRELLEV-------DSRTAKRDVRLKT-------------------SGRLLKFSFLKTE---FPLRPVTYFYDWLYINALVK--------------------------NRHLWPALSRA--------EGFTDIVFNP-------SKSLNCQA-----------------------------------YSAALFASLVRADKLSKAL  176  237813318  bacteria>proteobacteria>betaproteobacteria
    BCAM1881_Bcen_206563730              53   DRVLEISSKSK----DEYGVKLSAFN----LMIKTPR-----------------REYSLECAYQASK--VF-----------------ERGGPFTDLLNA-------KSIDAKRDPRLTQ-------------------FGRMIRFQWYGKE---WPLQPRTAFYDWLYINALHR--------------------------PQELAKIVLTY--------RAFSDIAFNP-------ERSINCQA-----------------------------------YAAALYVSLHERGLLRDEI  205  206563730  bacteria>proteobacteria>betaproteobacteria
    NEISUBOT_05210_Nsub_261381097        53   GKVLEISSKSK----SELGIALSAFN----LMIKSAKG----------------KRVSVECVFQSSK--VF-----------------EGDIQYLDLLEV-------SSREAKKDSRLKS-------------------SGMVIAFRTYGKKDKEWGTKPITAYYDWLYVNALNQ--------------------------HTEFHEELLEY--------SAFSDIEFNP-------EKSLNCQA-----------------------------------YSVALFCALYRRGILQDVL  208  261381097  bacteria>proteobacteria>betaproteobacteria
    Glov_2583_Glov_189425639             53   TNLLEISSKSK----TTLGVDLSAFN----LMITTIKY---------------NKTFSVESAFQSSK--VF-----------------EKGGPYLDLLDK-------TSREAKKDGRLQT-------------------SGRLKCFKFFGIE---WGLEPQTAFYDWLYINALKK--------------------------NSDYAEQVMEY--------SAFTDIEFNP-------ERSINCQA-----------------------------------YSAALYVSLCHRDLLEYAT  206  189425639  bacteria>proteobacteria>deltaproteobacteria
    HWAG_01373_Hwin_237752248            56   AKILEISKASP----NQLGQKLSAFN----LKLKVFNGIQ-------------DITASVERFFQGSK--VF-----------------NNGGPFEEIIFN-------ENIHPKKYDKLKK-------------------GCNFQGFKLFGKC---YSTEPVTFFYDWLYINALKQ--------------------------NSILATELENY--------DIFTDIEFNP-------NKSLSCQA-----------------------------------ATVALFLSLKKAGTLDKAT  211  237752248  bacteria>proteobacteria>epsilonproteobacteria
    CAMGR0001_0616_Cgra_257460202        53   EKILEISKASP----NPLGKALSAFN----LKLRLKDEEQN------------LIEASVERFFQGSK--FF-----------------ERGGPFEEIIFS-------AKVHPKKYPPLKN-------------------SGNFCGFELFGER---FSTEPKTYFYDFLYLSALKQ--------------------------NPNLADEVLRY--------DYFSDIEFNP-------KKSFSAQS-----------------------------------RAAALFVGLSRNGIFKEIF  209  257460202  bacteria>proteobacteria>epsilonproteobacteria
    Psyc_0321_Parc_71064897              53   DKILEVSSKSK----EDLGVALSAFN----LMIADKAT---------------KEKYSVECAFQSSK--VF-----------------ENGGAYTDLLKV-------TSKQAKKDERLRN-------------------SGKLIGFEFYNTK---WQLNPLTAFYDWLYVNALNQ--------------------------NVQLHDRLMQY--------QTFTDIEFNP-------KKSINCQA-----------------------------------YSIAMFVALAKRNMLESIR  206  71064897   bacteria>proteobacteria>gammaproteobacteria
    ACICU_00103_Abau_184156423           53   FNILEISSKSE----VELGVALSAFN----LMMFDKKT---------------HQKFSVECAFQSSK--VF-----------------QNGGPFLDLLNV-------TSREAKKDERLKT-------------------SGQLKKFTFYGID---WALDPLTAFYDWLYINALNF--------------------------NAEYHQELLAY--------EAFTDIEFNP-------EKSINCQA-----------------------------------YSIAMFVALSKRNLLDKVR  206  184156423  bacteria>proteobacteria>gammaproteobacteria
    HMPREF0198_1779_Chom_258545510       63   KNILEASSKSE----QPLGLPLSAFF----LK--DEDG------------------VPVENLFQSSK--VF-----------------ENGGAFLDLRHV-------SPRAAKKDLRLKE-------------------SGAMLKFLFNGKE---FPLEPKSLFYDWLYSKILYG------------------------NNNIELKNQLINE------VFDAFSDIEFNP-------KKSFSCQA-----------------------------------RTLALFISLHSTNCLKEFI  216  258545510  bacteria>proteobacteria>gammaproteobacteria
    Pcryo_0891_Pcry_93005719             60   NHVLELSSKSG----NKLSFLLSPLS----LKLTNENG---------------GEQYSVENAFQSSM--VF-----------------EDGGPYIDLLSA-------PPRQAKKDERLIN-------------------SGELIGYNYFGME---WSVEPLTTFYDWLYVNALKQ--------------------------NPHLHEEVMQY--------QAFTDMEFNP-------KKSIHGAA-----------------------------------YALAMFVALHKRELLDNIE  213  93005719   bacteria>proteobacteria>gammaproteobacteria
    Psyc_0844_Parc_71065404              67   NHVLELSSKSG----NKLSFLLSPLS----LKLANEHG---------------GEQYSVENAFQSSM--VF-----------------EDGGPYIDLLTA-------PPRQAKKDERLIT-------------------SGELIGYNYFGME---WSVEPLTTFYDWLYVNALKQ--------------------------NPQLHEEVMQY--------QAFTDMEFNP-------KKSIHCAA-----------------------------------YALAMFVALNKRELLDNIE  220  71065404   bacteria>proteobacteria>gammaproteobacteria
    GPB2148_1261_Mgam_254482777          24   EGILEISTKSP----ESLGVSLSAFN----LTYQPENS---------------DKRYPLESLFQSAK--VF-----------------TDGGPYRDILSK-------PAREAKSDPRLTT-------------------SGRLVAFSSRDTT---WPLVPRTAFYDWLYLNVLGH--------------------------YPRLAEPLSMF--------GGFTDIEFNP-------KKSINCQA-----------------------------------YSAALFVALSERKLMAKAM  177  254482777  bacteria>proteobacteria>gammaproteobacteria
    XAUC_02590_Xfus_294664143            60   DRVLEISSKSP----DSLGVDLSAFN----LMIKTVKH---------------EREFSLECAFQASK--VF-----------------ENGGPYKDLLNA-------RSLDAKRDPRLKE-------------------SGRLIKFRFFNVD---WELEPRTAFYDWLYINALHK--------------------------PQDLAEKVLTY--------RAFSDIAFNP-------DKSVNCQA-----------------------------------YAAALYVSLQERGLLSETM  214  294664143  bacteria>proteobacteria>gammaproteobacteria
    V12B01_14190_Vspl_84392320           54   GSILEVSSKSL----DELGVSLSAFN----LCITTKLK---------------KQSFTVETAFQGSK--VF-----------------EQGGPYLDLIGM-------DSRAAKKDLRLKE-------------------SGNLIYFEFFGKK---FPNTPRTFFYDWLYINALVQ--------------------------NQDLAIQVEAY--------DAFSDIEFNP-------KKSINCQA-----------------------------------YAIALYVSLAKNGLLEQAL  207  84392320   bacteria>proteobacteria>gammaproteobacteria
    A5C_A0388_Vcho_153817467             52   NNILEISSKSL----DELGILLSAFN----LSFVTKKH---------------NHKITVESAFQGSK--IF-----------------KRGGPYKDLYLA-------DSRTSKKDIRIKD-------------------SGQLVGFKFFNTE---FPLIPRTYFYDWLYIKALVS--------------------------NPQLVDQLYKF--------DGFSDIEFNP-------KKSINCQA-----------------------------------HAAALYVSLNSAGVLEEAL  205  153817467  bacteria>proteobacteria>gammaproteobacteria
    PsycPRwf_1182_Psp._148652988         60   KNVLELSSKSG----NKLSFPLSPVS----LKITNEED---------------GQQYSVENAYQASK--VF-----------------KGGGPFVDLLDA-------APRQAKKDERLMS-------------------SGEITGYDYFGMV---WGLEPLTVFYDWLYVNALKQ--------------------------PNHLHQEVLQY--------QAFTDISFNP-------KKNVHCPA-----------------------------------YSLAMFVALHKRELLEGIE  213  148652988  bacteria>proteobacteria>gammaproteobacteria
    FPR_02440_Fpra_295103146             48   VSILEVSSASA----QPEGEAVSSLR----LLLRLNSV---------------AQDVPISTVFEAAK--VF-----------------EHGGPFADLLTC-------APSKVHKDTRLRT-------------------NGKLLRYSLEGSEY--PIEPHPDSFFEWLYCRALKQ--------------------------PFEKAAQLSRY--------NAFSDIAAAA-----DSKKYYGDSS-----------------------------------RAAAIYVGLAAAGKLPCID  204  295103146  bacteria>firmicutes
    _Fpra_160945657                      72   VSILEVSSASV----QPEGEAVSSLR----LLLHLDSV---------------AQDVPISTVFEAAK--VF-----------------EHGGPFADLLTC-------APSKVHKDTRLRT-------------------NGKLLRYSLEGSEY--PAEPYPDSFFEWLYCRALKQ--------------------------PFEKAAQLSRY--------NAFSDIAAAA-----DSKKYYGDSS-----------------------------------RAAAIYVGLAAAGKLPCID  228  160945657  bacteria>firmicutes
    KSE_10250_Kset_311894452             22   AVIVDTTSKAP-----DPWVRLSPFYPHGGIPVPFSPG---------------VTAQSVEGIWQALK--VF-----------------ESVDTDPAKLDV------TTMKGLKRTVRRFG-----------------PVRGHRAGLDGTELL---PYQEARRRIYLPAYRWTLEH--------------------------VRPDLLERLRA-----EEHLVLLDYTTNG-------DVADTGSP-----------------------------------LSHAALIRRHLEGRWPDEG  186  311894452  bacteria>actinobacteria
    OSCT_1675_Otri_309791192             22   ATLLDVTSQGP-----APWVRFSPFYPHGAIPVPLSPG---------------MTAASVEGIWQGLK--VF-----------------THANIDLNTMTN------TTMRGLKRTTRRFG-----------------AVQGHRAGVAGTTLL---DYATARQRIYLPAYRWVLDH--------------------------LCQPELDDLRQ--RASQGLVVLLDYETNT-------DLADLRRP-----------------------------------LSHAGLIIRYLDGTWPVS-  184  309791192  bacteria>chloroflexi
    Tcur_0355_Tcur_269124625             22   ALILDVTSRAE-----RPWARFSPFYPHGGIPVPFSPG---------------VTAQSVEGIWQALK--VF-----------------ANADVDPAKLEI------TTMKGLKRTVRKHG-----------------PVRGHRAGLTGEVLL---PYEQARRQIYLPSYRWVLEH--------------------------VRADLMDRLKE--LSSRGDIVLLDYTTNG-------DVTDLSAP-----------------------------------LSHAALIRCHIEDRWP---  182  269124625  bacteria>actinobacteria
    HCH_04340_Hche_83647036              29   YAIIDVTSKAS-----APWVKFSPFYPHSGIPIPFSS----------------ETAQSVEGIWQGLK--VF-----------------EGQDIDPSRFDI------TDMKGIKRTVRRYG-----------------RVLGHRKGPGGE-LI---PYIEARKQIYLPAYHWTLTH--------------------------LRQAELSQLSE-LLARHEGLVLLDYETNT-------DINDPRKP-----------------------------------LSHAALIRRFLQP------  185  83647036   bacteria>proteobacteria>gammaproteobacteria
    Caci_4610_Caci_256393748             22   ARIIDVTSKGP-----QPWVRMSPFFPHSGIPVPLSDG---------------AVSQSVEGIWQALK--VF-----------------PGSDVDPRKLDV------ASMTGLKRTVRKHG-----------------PVLGHRAGLNGQDLL---PYEQARRRIFLPAYRWVLEH--------------------------VNTDLIAELRA----ADGDIVLLDYTVNG-------DVTDTSSA-----------------------------------LSHAALIRLYVEDRWP---  180  256393748  bacteria>actinobacteria
    M23134_02260_Mmar_124004845          21   YKIIDVTSKAP-----TPFVKLSPFYPIGDIPVPLSEG---------------HFAQSVEGIWQGLK--VF-----------------ETASIDLKKLEV------TTMKGLKRTVRKFG-----------------NVKGHQAGVNNHNLL---PYIIARKQIYLPAYRWVLDH--------------------------VKSDVLQLIKN--EAEQHPIILLDYETNG-------DVENASKP-----------------------------------LSHAYLVKYYLENNFP---  181  124004845  bacteria
    _Krac_298250178                      22   VQVIDVTSRGA-----DPWVRFSPFYPHGDIPVPFSPG---------------YTSWSVEGVWQGLK--VF-----------------EQAGVDVSKFRI------ANMKGIKRSGRSLG-----------------GVLGHREGVDGERLL---GYREARSAIYLPTYRWVLEH--------------------------LEQPELETLRQ--LSAQASVILLDYETNA-------NIDDLRRP-----------------------------------LSHAALIKAYLTAPED---  182  298250178  bacteria>chloroflexi
    GobsU_010100001512_Gobs_168698168    22   ATVADVTSKGP-----EPWVRFSPFFPHGGIPIPNTPD---------------ETAASVEGLWQGLK--VF-----------------EKEDIDPKKWAI------TDMRNIKRAGASRG-----------------AVRGHRFGVGSGTLL---GYREARFRIYLPAYAWVLER--------------------------LCAREVEQLRG--IARAGTVVLLDYETNT-------DAEDLSRP-----------------------------------LSHAALVRHFLEETWP---  182  168698168  bacteria>planctomycetes
    GobsU_010100034385_Gobs_168704676    25   SVVYDVSSYAE-----PPHCELSPMWVHGGVPVPGAPG---------------ETSDTVEGVWQGLK--VI------------------RGQTAPRYFR---------GPGAKRGG---------------------KPSGHRFGTR---LL---GVVEARRLIYVPTYEWVIEN--------------------------TRSPEQIRAFIDAAFAGVTQHFHDVGDNG-------DPNDATQP-----------------------------------LAQAAVLVRYLNRKCAERA  182  168704676  bacteria>planctomycetes
    BXY_40670_Bxyl_295087466             21   AVILDITSNSE----TRYAKILSPFYPHGNIPIPFTDG---------------LKATCVEAVWQGLK--VF-----------------EGVGVDFATFKN------DTMRDLKRTVRKYG-----------------VPKGHSKGAYSKELL---GYFEARMLIYLPTYKWVLDN--------------------------PVEVHHVVERIKEQSKIQDIVLLDYNTNI-------DFRDISKP-----------------------------------MSHAGLVKLYIEGKYPDNM  191  295087466  bacteria
    HMPREF0665_01551_Pori_299141967      21   ADILDITSNSE----TRYAKILSPFYPHGNIPIPFTNE---------------LKATCVEAVWQGLK--VF-----------------DSVDVDFSTFKN------DTMRNLKRTVRKFG-----------------KPKGHRKGAYGKELL---NYFEARMLIYLPTYKWVLDN--------------------------PVEVHRVVERIKEQSKKRDIVLLDYNTNT-------DFRDISKP-----------------------------------LSHAGLVKLYIEGNYPEGM  191  299141967  bacteria
    Bfra3_010100013815_Bfra_255010211    21   AVILDVTSNST----MRYAQILSPFYPHGNIPIPFTPD--------------TLKATCVEAVWQGLK--VF-----------------ENADVDFSTFKN------DTMHNLKRTVRKFG-----------------IPLGHRKGAYGKELL---GYFEARMLIYLPTYKWILDN--------------------------KIEVYHVVERIKAQSIKQDIVLLDYNTNI-------DFRDITKP-----------------------------------LSHAGLVKLYIEGKYPNEV  192  255010211  bacteria
    Bcep1808_6822_Bvie_134288349         18   AVVVDTTSRSA----TSWSRAFSPFYL---GPADLYDG---------------HVARTVENGWQYAK--VY----------------ADQLGADGNPNEAYWAWAKAGWGKMRADRYPRG-----------------KGAKPVFCWWNGTKL---GYIEARLKVYFPLYRDAV-R--------------------------TQEAFNQLVRL---ARDRTIVLWDFDGF--------DHQTIGLS-----------------------------------LANVLLDDSRPMGHA----  179  134288349  bacteria>proteobacteria>betaproteobacteria
    bthur0002_58540_Bthu_228982721       89   LNVLECSTKGD--------KRFSALS----AKVSVHDV-----------------FDTIENHYQKSK--VF-----------------QDESGFYYTCKKW------ENAKGKKPVA---------------------------CKIGNTIL----SIEYLSMFYELLWYKYLKS--------------------------ENYLEEVLAKF--------DEYHDMFKS--------KKSMVCQA-----------------------------------DTIREYMKNENDEWY----  221  228982721  bacteria>firmicutes
    MexAM1_META2p0262_Mext_240141986     7    APFLECSSRGD--------QRFSAFS----ARLR-SQG-----------------GRSIEEVYQAAK--VF------------------EDGSTGLGWR---------DAKGKRAVN---------------------------------------MPEVRR-LYSRLWDAYIDE--------------------------PNELLALIQVQ--------SGLSDVFG---------QQGNACQA--------------------------------------TELWRIRAERAAVGGV  125  240141986  bacteria>proteobacteria>alphaproteobacteria
    16-3p043_BP16-3_195546573            7    APFLECSSRGD--------RRLSAFH----ARIR-SRG-----------------NKSIEDIYQAAK--VF------------------ADGSSGLSWR---------EAKGKRAVN---------------------------------------MAEVRE-LYARLWDEYIGE--------------------------PNALLDVVRAA--------SGLSDMFG---------QSGSACQA--------------------------------------TELWRIRNKEQA----  121  195546573  dsdna viruses, no rna stage>caudovirales
    MAR_ORF111_MV_284504143              1    ------------------------MAL---GPVEHVHPA-------------LPPAKNIENFYQGSK--VF--------------VQEVDKDQNPTSLFYENRERLFSDEIPKRHKYKGMGKN--------------KNIPLYFLWTDKCGK----EHRLDYIQSRQTYCNFFER--------------------------ALSDTEDYRKL--------CRLQDKGYNLIFCGY--DAHDIPEDTPKI-------------------IEEAYLDPSVPF-GHERVLFAMLALRDTPEE  169  284504143  dsdna viruses, no rna stage
    LAU_0089_LV_327409634                109  FPNFRHQKRKD----GFGCSNLSPMTL---GPVKHTCPG-------------LEPAKNIENFFQGSK--VF--------------SEEVDKHKNPSSLFYENREMLFADPVPKRHKYKGVGKN--------------KNIPLYFLWTDSEGK----EHRLSYIESRQTYCNFFER--------------------------ALSETKDYRKL--------CRLQDKGYNLIFCGY--DAHEITGS-----------------------IEDAYLDPSVPF-GHERVLYAMLALRDTPEE  284  327409634  dsdna viruses, no rna stage
    NAEGRDRAFT_46602_Ngru_290997341      83   YKNVNCCSGAS----GI-FKELSPMKL---GPYEYEHGSE------------KCTITNLENLWQFSK--VF-----------------PGEEEQVRN---------DNGQLTKVPNSEFF-------------------ERRTKGWKDEKAH---RHVKREKPLYSWWKGEKFNY--------------------------QMARRKIYCPL------YAEKVVETEAYK-------KLEEMVNS------------------------------------GMNIQILGFDGYNYDGKT  240  290997341  eukaryota>heterolobosea
    consensus/100%                       -    ...hp.sp..............ush.................................lp..hb..b...b.........................................p...................................................h...b...h.................................................h.c............p.............................................................
    consensus/95%                        -    ...lphoo.............hSsh.......h........................slp.hab..K..hh.........................................+p.................................................ha...h...l.................................................h.-............p......s......................................................
    consensus/90%                        -    ..hl-hoo.u...........hSsh.......h........................slE.haQu.K..la...................ss.....b..............K+.................................................ha...a...l.p...............................................h.Dh...........p....s.s......................................sh..b...........
    consensus/85%                        -    ..ll-loo.u...........hSsh.....h.h........................slEshaQu.K..VF...................ss.....h.............hK+..p.......................s........s...........p.hY..hY...l.p...........................p...................h.Dh..s........p....s.s......................................shhhb..b........
    consensus/80%                        -    ..lL-loSpu........s..hSsF.....l.h........................slEshaQu.K..VF.................p.ss...pbh.........s...hK+s.c.......................s....h...s.p.......sbp.hY..hY..hL.p...........................p.....l.ph.........sh.Dhp.N........p.s..sps......................................shhhb..l........
    consensus/75%                        -    .plL-lSSpS........u..hSsF.....l.l..ps....................oVEshaQu.K..VF.................ppuss..pbh.........s.bphK+ssR..s....................s....h...s.p......psbp.hY.bhY..hL.p...........................pph...lbph.........sh.Dhp.Ns.......cbs.ssps......................................uhhhbh.l........
    consensus/70%                        -    .plL-lSS+S........u..lSsF.....l.l..ps....................oVEshaQuuK..VF.................cpuss..shhp........ssbphK+ssRbbs...................ssp...h.h.spp.....bpsbp.hYpbhY.phLpp...........................pph..plbph.........shsDhp.Ns.......cbs.sspu......................................uhhlhh.Lp.p.....

    #==== YbiA-like family

    #== gp30.3
    _Bpar_33595978                       4    ASRLNISSTSD----DWRGLALSNFPL----SPFVLDG---------------ELFASVEGFIQGIK---FR----------------EDDPRRATAFLS-------SGWDAKHLGD--------------------TVDRSGAYWGGARIRY---GSAEHHQLIERAIRARIKQ--------------------------CEGLRRTLRAT------EGMTLVHDTGKP-------EAPHTSLPAT-------------------------------------VFCRILETLRREILA  152  33595978   bacteria>proteobacteria>betaproteobacteria
    _Bbro_33601359                       4    ASRLNISSTSD----DWRGLALSNFPL----SPFVLDG---------------ELFASVEGFIQGIK---FR----------------EDDPRRATAFLS-------SGWDAKHLGD--------------------TADRSGAYWGGARIRY---GSAEHHQLIERAIRARIKQ--------------------------CEGLRRTLRAT------EGMTLVHDTGKP-------EAPHTSLPAT-------------------------------------VFCRILETLRREILA  152  33601359   bacteria>proteobacteria>betaproteobacteria
    30.3_BPRB43_66391541                 1    M-DIGSGSQY-------PSCALSNFAP----HPFTFDG---------------VECASMEGFLQSLK---F-----------------SNPDMQAHVCTL-------VGKAAKFKGKKKK-----------------WWTTQTLYWKGIPIHR---ESEAYQILIENAYNALFL---------------------------NEGFRRALKAT------GKSTLTHSMGKN-------KMNETVLTER-------------------------------------EFVRNLTRLRDLL--  146  66391541   dsdna viruses, no rna stage>caudovirales
    BMS_2150_Bmar_301167374              62   EGEVILSKRN-------ELGILSNFAA----TDFVYKG---------------TLYKSVEGFWQSLK---YP-ESQDDMRATF--EGIEWPYSRAEVELM-------TGFLAKKAGGYAN-------------ANMREMGIDWVTFQGKKIKFWTVSKGVHYRLIKDALRTKAIQ--------------------------NPKVMEILLST------GDLKLLPDHIMG-------DAPPAWFYNK-------------------------------------IWMELRKEFRE----  228  301167374  bacteria>proteobacteria>deltaproteobacteria
    PT7_2661_Psp._332285914              5    DTHLNVAYTST----DWRGVALSNFSL----SPFVFDD---------------QLFASVEGFIQGLK---FP----------------EGDARREQAFQS-------CAWEAKKIGE--------------------QADKSAAYWAGECMAF---GSTEHHRLVGRAVRVRIEQ--------------------------SQGLCQVLIST------KGLELVHETGHG------PEPAITSLPAA-------------------------------------VFCRVLTDLRGELLA  156  330429867  bacteria>proteobacteria>betaproteobacteria
    Gbem_1485_Gbem_197117872             1    M-DVGGYTTG-------IAGRLSNFTP----RAFVLDG---------------FHCACLEGALQAFK---F-----------------DDPEMQKRICMM-------SGKEAKTIGQTRN---------------EAWQSCQTLWWQGKAYDR---LSPEYQQLLDRLYEAALL---------------------------SADFADDLLAT------GDEVLSHSIGEH-------DPRKTVLTEE-------------------------------------EFCSRLMANRSKVKK  150  197117872  bacteria>proteobacteria>deltaproteobacteria
    gp30.3_BPSP18_308814565              1    MSELEIRSNF-----PWPSCALSNFAK----WPFVMDG---------------IQFGGLEGFLQGCK---V-----------------RNCEQQKRIFGM-------SGLTAQQTGRAYA----------------RAADRGTLFWLGIPFSR---YSTSWKELYTNAYFEAALQ--------------------------NKGFRDALQAT------KGKVLKHSMASH------LTVHDTILTEQ-------------------------------------EFIDILNQLRDAL--  152  308814565  dsdna viruses, no rna stage>caudovirales
    30.3_BPIME08_299779149               4    MSELEIRSNF-----PWPSCALSNFAK----WPFVMDG---------------IQFGGLEGFLQGCK---V-----------------KNVEQQRRIFGM-------SGLAAQQAGRAYA----------------RAQDRGTLFWLGTPFSR---YSTAWKELYESAYFEAALQ--------------------------NKGFRDALQAT------KGKVLKHSMASH------LTECDTILTEK-------------------------------------EFIDILNKLRDLL--  155  299779149  dsdna viruses, no rna stage>caudovirales
    30.3_BPAeh1_38640191                 1    MLDIHIGTAY-------PGNVLSNLAH----NAFVFDD---------------IRCGGMEGLLQSLK---F-----------------QDVNKQIQIAAM-------SGTAAKFRGAKKK-----------------WYNGQTLYWKGVPFSR---HTDAYQNLLDNAYDEMFVQ--------------------------NESFRKALTDS------KNTVLCHSIGHT-------DPFRTILTVE-------------------------------------EFLCRLNRLRSLLLV  150  38640191   dsdna viruses, no rna stage>caudovirales
    phiAS5_ORF0053_BPphiAS5_310722519    1    MLDISVSALY-------PANELSNLAK----HEFIFDG---------------VRCGSMEGLLQSLK---F-----------------QDVEKQIAIAAM-------WGTGAKFRGAKKA-----------------WYNDQTLYWKGVPFSR---HSEAYQNLLDNAYDELFVQ--------------------------SESFRKALTSS------GNTVLCHSIGHN-------DPMRTILTVE-------------------------------------EFLCRMKRLRSLLLA  150  310722519  dsdna viruses, no rna stage>caudovirales
    30.3_BPKVP40_34419305                1    M-DIKSGAGY-------PASALSNFAP----HAFVVRG---------------VECASMEGFLQSLK---F-----------------KNPEMQREVCKL-------VGKVAKARGSKKN-----------------WQRTQTLYWQGEPIQR---ASVGYQTLLDDAY-AALAQ--------------------------NVKFQKALLAT------GKATLTHSIGRK-------KQAETVLTVQ-------------------------------------EFCSRLTVIREHLQN  148  34419305   dsdna viruses, no rna stage>caudovirales
    30.3_BP65_326536778                  1    VIDI-YSGSS-----NWIERELSNFTE----HTFTFDG---------------VYYRTIEAFLQSLK---Y-----------------ENPPDINGLRGH---------EVYRFCHNHIG-----------------WKKDLTMWYKGRPIHR---LSDAYSNLIYNAYLSMAEQ--------------------------NKSFLEALVHS------KPHILAHTMGCK-------DPHHTILTEK-------------------------------------EFCDILTEIRELI--  149  326536778  dsdna viruses, no rna stage>caudovirales

    #== YbiA
    ALIGN                                -    ---EEEE--------------------------EE----------------------HHHHHHHHHH-----------------------HHHHHHHHH----------HHHHHH---------------------------------HHHHH---HHHHHHHHHHHHHHHHH-----------------------------HHHHHHHHH----------EEEEE------------------H-------------------------------------HHHHHHHHHHHHHH---
    HMM                                  -    ---EEEEE-------------------------EEEE----------------EEE-HHHHHHHHH------------------------HHHHHHHHHH--------HHHHHHHHHH-------------------------HEEH-HHHHH---HHHHHHHHHHHHHHHHHH---------------------------HHHHHHHHHH----------EEEE------------HHHHHHHH-------------------------------------HHHHHHHHHHHHHHHH-
    FREQ                                 -    --EEEEE--------------------------------------------------HHHHHHHHHH-----------------------HHHHHHHHH----------HHHHHH---------------------------H-HHHH-----------HHHEHHEHH-HHHH-----------------------------HHHHHHHHH---------EEEEE--------------EE------------------------------------------HHHHHHHHHHHHHH--
    PSSM                                 -    ----------------------------------EE----------------------HHHHHHHHH-----------------------HHHHHHHHH---------HHHHHHHH-----------------------------------------HHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHH---------EEEEE--------------EE-----------------------------------------HHHHHHHHHHHHHH---
    FINAL                                -    --EEEEE---------------------------EE-----------------EE--HHHHHHHHHH-----------------------HHHHHHHHH---------HHHHHHH---------------------------HHHHHHH-------HHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHH---------EEEEEE-------------EE-----------------------------------------HHHHHHHHHHHHHHHH-
    PDB(2b3w)                            -    --EEEE-----------HHHHH-----------EEE-----------------EEE--HHHHHHHHH-----------------------HHHHHHHHH---------HHHHHHHHH----------------------------H-----------HHHHHHHHHHHHHHHHHH---------------------------HHHHHHHHHH---------EEEE----------------------------------------------------------HHHHHHHHHHHHHHHH
                                                                                                                                                                                                                                                                                           #                                           #    #      #
    IIV6gp151_IiV6_15078868              19   -DTIVLKHEE-----DKPFGPLRNDYK----SDLYIDG---------------KRWNSVDNYVFSNL---L----------------PSIDFRKQTIEHL-------NPHQVEKTYYDV-----------------------KFEIN----------KSTLSSAIKIGIESKLIA--------------------------DPQFRQALLNT------AGSSIMYLSKNN-------YLGYGNGKWF-----------------------------------VNTYGIWLEHFRTGMLW  159  15078868   dsdna viruses, no rna stage
    ORF234_BP0305phi8-36_156564215       7    SNAIRFYSGS------DNYSEFSCMSK----HPVVIAG---------------TEYPTLEHYYHAQK---F-----------------IDLEPVEEILAT------NNPFEARRLGQRTD-------------------YPIHEDW-----------DVMKEHVMFVGLIHKFKQ--------------------------HEWLRTLLLST------GDKELIHHSDR--------DRYWGQSVTG---------------------------------KGKNRLGIMIMNVRERIKN  151  156564215  dsdna viruses, no rna stage>caudovirales
    Deipr_2488_Dpro_325284428            43   QEVTSFTG---------PFSFLGNFHS----EKAVRYG--------------ALQFQTLEAAFQAAK---T-----------------GDVDIQRRIAAA------PSPKEAKAIGRALQ---------------------LREDW-----------EDMKEQVMLDLLREKFS---------------------------HRVYREQLLGT------GLVPLIHNNAHK-------DAFWGVYKGE----------------------------------GQNRLGKLLMQVREEIRA  182  325284428  bacteria>deinococci
    TVAG_227690_Tvag_123462122           1    --MINIYYSTN------ENAELSNFAI----RPFIING---------------VRYDSVEQYFQIMK---FKIEAVYTYDKDSEEGRKSKEKIDSLIQKMQNT---KSGSLLKKLGNTRI----------------KNAKFNSGLW-----------TQESQNVMREGIFESFKQ--------------------------NPPFLKKLLET------GDATLTHNQDK------------------------------------------------SRW-GK-LFPKILMEVREQLKE  157  123462122  eukaryota>parabasalia
    Mmc1_1181_Masp_117924481             22   PTMVALLPPI-------WYSCFSNFSD----HPFELDG---------------KLWFTVEHYFQAAK---F-----------------ADPQQRARIYAC------PSPMTAALMGKDRS-------------------IPIRADW-----------DAIKLDVMRQALNAKFDT--------------------------HQQIHDFLQAT------HPYPLLNYTAF--------DPFWGQDKRG---------------------------------HGQNQLGKLLMERRSRML-  164  117924481  bacteria>proteobacteria
    Msp_0486_Msta_84489297               69   DAQELIKSTLK----PLFIKLWTRDGK----PKYNIDFN--------------EDKNYIQMYDTIYK----------------------DTTHHIHIGT-------KTYDSAKEIISLIE---------------NDLKSKSPELW-----------NELKYTLYLNALYYKIVT--------------------------DINFTKELIKT------KDRCIVFKSDN---------LEWGVTIDD------------------------------GKLIGQNLFGFAMMEIRDVLCD  219  84489297   archaea>euryarchaeota
    SrosN15_010100002350_Sros_239939813  220  QLYQSYPNKPVA---DPGHRGLRNDYP----APITVGE---------------VLHPSVAHAYWALS---V-----------------AQPEVSSAITAA------DTAAAARKLAAAAP---------------------RREGW-----------EHSRTAVMTGLLRAKYDQ--------------------------HPELAEILLAT------DDATLIYDDME--------SAFWGDNAGR----------------------------------GRNWTGRLLELVRSELHL  364  239939813  bacteria>actinobacteria
    LbrM06_V2.0110_Lbra_154331017        12   QNVVTFCEAH-----DPQYGVLSPLSP----SPLVVRH---------------VQYPSLHHYFLCER---F-----------------KGSPAEQWVTEA------TTVWSLDRLVKAAE-----------------AEGYQRSNW-----------NKVKVDVMLLGTYLKFKQ--------------------------NEAARAVLLST------HPSLLLYHTPK--------DDFWGDGGDG---------------------------------TGKNVLGVVTMTARARLHS  159  154331017  eukaryota>euglenozoa>kinetoplastida
    LinJ06.0130_Linf_146070759           8    QNVVTFSEVH-----DPLYGVLSPLSP----SPLVVRH---------------VQYPSLHHYFLCER---F-----------------KGSPAEQWMAEA------TTVWSLERLVKTAE-----------------EEGYQRHNW-----------NKVKVDVMLLGTYFKFKQ--------------------------NEAARAVLLST------QPSLLLYHTPT--------DDFWGDGGDG---------------------------------KGKNVLGVVNMAVRARLHS  155  146070759  eukaryota>euglenozoa>kinetoplastida
    Tc00.1047053507521.60_Tcru_71654521  3    KGVVRFHDVH-----EVPYGVFSPLSP----HPIVIRH---------------KQYPSVHHYFLTER---F-----------------RDAPVTAALRSA------TSVWELDRLVKEAE-----------------RTGSQREDW-----------NRVKVDVMLLGNYMKFKQ--------------------------NEAVRSLLLET------GDKLIIDHTTS--------DDFWGDRGDG---------------------------------SGKNLLGVILMAVRDRLRR  150  71654521   eukaryota>euglenozoa>kinetoplastida
    Tb927.7.4780_Tbru_72391614           3    KGVVRFHDSR-----EKPYGVFSPLSP----HPVTIHH---------------TQFPSLHHYFLTER---F-----------------GGLPDAAPFQSA------ASVWELDRLVRVAE-----------------REGRQRGDW-----------DRLKVDVMLLGNYMKFKQ--------------------------NENAREILMNT------GTRLIVDHTEE--------DDFWGDAGDG---------------------------------TGHNLLGVILMAVRDRLHR  150  72391614   eukaryota>euglenozoa>kinetoplastida
    TTHERM_00998900_Tthe_118397133       37   EQVIKFTHKLH-----DKYGFLSNLFQ----SKIMIDK---------------LQFMSVEHYYQAMK---F-----------------EGTKKFEVIRRA------GKAIDAHKLAQKKD-------------------TPKNRDW-----------QDLKVAYMKKAIQAKFQQ--------------------------NKALKKQLIET------YPNKLVDVTPG--------DKFWGIGDKE---------------------------------EGKNMNGQILMEIRE-LCM  181  118397133  eukaryota>alveolata>ciliophora
    OSTLU_35648_Oluc_145348536           4    LPPVKFYKAW------DEYGALSNFSP----FPVSVDG---------------VEWPTVEHYYQAQK---FAGVH-----------NDIARESFEKIKLA------ESPEAAAKIGRSAQ---------------AAHPESVRKDW-----------DDVKVDVMRRALTEKLVR--------------------------YEGPRTLLMESVCTD--GRVRVIEDSPV--------DGVWGAGRDG---------------------------------TGQNLLGALLVNIREDLVS  162  145348536  eukaryota>viridiplantae>chlorophyta
    Plabr_0990_Pbra_325107565            1    --MILIRKVK------DEYGWLGNMSS----FPVLYEG---------------KKYRTTEALFQALR---F-----------------DHEKIIESIREQ------KSPMSAKMKAKKHR------------------NRMVVVPL-----------SEADLDNMRLVLRLKLLQ--------------------------YPKLRTLLLAT------GDQEIVEDCTKRPR---GSGLFWGAANRD------------------------------GKWIGENWLGRLWMELRTELTQ  152  325107565  bacteria>planctomycetes
    PRU_0382_Prum_294673143              23   DKCACIRKTT------EEWGIFGNFFY----APIIVEG---------------VTIDCTERLFHLMK---FNA---------------NGEEGIKSEYAA------KRGMAIKMHMKPIY---------------KSHPEWLRNDW-----------GAMVVDAMRFCLQTKYEQ--------------------------CEAFRKELERS------KGLFIVEDETKRNEKKKADADSWGTNLVG------------------------------NEYVGPNLLGRLLMELRDNGKL  184  294673143  bacteria
    DICPUDRAFT_22458_Dpur_330798615      1    ---IKFFNNG------DPYYEFTNFYE----ACFNLDG---------------LYWKTSEHYYQAQK---FS----------------PNKAIMEQVRHL------PNPREAFKFGNFKG-----------------HKHFIRKDW-----------HDIKEEIMEKAIRAKFEQ--------------------------NSKLQNLLFKT------KGSELIENSPF--------DDYWGIGINN---------------------------------NGQNRLGVILMKVRDSL--  143  330798615  eukaryota>amoebozoa>mycetozoa>dictyosteliida
    DICPUDRAFT_35661_Dpur_330802814      24   SGELKFYSQG------QDFYEFTNFYE----SPFNLDG---------------KLWTTSEHYFQAQK---FS----------------PDQALIELVRNL------PSPREAFNFTRIPD-----------------LQKDIRKDW-----------QEVKYTIMCDALFAKFTQ--------------------------NNHLRKLLLST------DDMKLIENSPV--------DYYWGEGKDG---------------------------------TGENKLGEILMELRRNLKT  171  330802814  eukaryota>amoebozoa>mycetozoa>dictyosteliida
    DICPUDRAFT_42446_Dpur_330843562      24   SGELKFYNQG------QDFYEFTNFYE----SPFYLDG---------------KLWTTSEHYFQAQK---FS----------------PYQSLIEHVRNL------PSPREAFNFTKKPD-----------------LQIDIRKDW-----------HEIKDIIMYNALFAKFTQ--------------------------NHYLRQLLLST------GDMKLIEDSPI--------DNYWGVGKDG---------------------------------TGKNKLGETLMDLRRSLNM  171  330843562  eukaryota>amoebozoa>mycetozoa>dictyosteliida
    SELMODRAFT_413953_Smoe_302783817     153  STVIYFYKSW------DPYGAFTNFTA----HSIKLPGSS-------------ETWKSVEHYYQAQK---FSGVK-----------DELAMQAIENIRNA------ESPEEAARIGRRLA---------------RERPDLVRPDW-----------ENSKMDVMEEALVAKFSS--------------------------YPQLRSLLLST------AGCVLIESSPQ--------DYFWGSGKDG---------------------------------TGQNQLGRLLMKLRAAILT  309  302783817  eukaryota>viridiplantae
    NPH_6632_Dpro_301059840              13   IDSVVFRKTI------EKFGGLSNMAP---GFPLQIGD---------------ISVRTSEALYQACR---FP----------------YAEEIQKMIISQ------KSPMTAKMKSKPFR-------------------SQTRPDW-----------DHVRVKVMRWSLRVKLAC-------------------------NWDKFRNLLLLT------ADKQIVEDSRR--------DRFWGAVAND-----------------------------EDYLEGENVLGRLLMEIREELKS  164  301059840  bacteria>proteobacteria>deltaproteobacteria
    PSYMP_06728_Psyr_330874307           12   SNSIVFLKTS------DEFGGLSNMAG---GFPLFVNE---------------RKILTSEALYQVCR---FP----------------HLPEVQCLIVSQ------TSPMTAKMRSKPFR-------------------SESRPDW-----------MRVRVRVMRWCLRAKLVQ-------------------------NWDRFSKLLLMT------EGLPIVEQSSK--------DKFWGASPQN-----------------------------DNKLVGANVLGRLLMELREDIVS  163  330874307  bacteria>proteobacteria>gammaproteobacteria
    PE36_21039_Msp._149908726            2    IDEIQFYEPN------DDFGFLSNFAL----AAVKIDG---------------VVWPSSEHFYQAQK---F-----------------NDPQLQDFIRTA------TTPDEAFSLSREYA-------------------QLVKSDW-----------MAVRDGVMRDVVMEKFSQ--------------------------NPFYAYQLVAT------GEQVLTEHSHK--------DAYWGDGGDG---------------------------------QGRNELGKILMNVRHQLAS  146  149908726  bacteria>proteobacteria>gammaproteobacteria
    VME_08600_Vhar_269960099             2    VDQILFYEPD------ESHGFLSNFCQ----AQIKVST---------------QSWPTSEHYYQAQK---F-----------------SDRELQDKILTA------KSPDEAFALSRKYQ-------------------HLVREDW-----------DDDKLSVMAFIVREKFLQ--------------------------NPQLAKQLMET------GNACLTEHSHK--------DAFWGDGGDG---------------------------------SGENHLGEILMNVRAELKH  146  269960099  bacteria>proteobacteria>gammaproteobacteria
    VPA0006_Vpar_28899861                17   VDQILFYEPD------EPHGFLSNFCH----APVEISS---------------QSWPTSEHYYQAQK---F-----------------VDAQLQTKIQKA------QSPDEAFALSRQYE-------------------HLVRSDW-----------DNMKLSVMAFIVREKFLQ--------------------------NPKLAQKLMRT------GNACLTEHSHK--------DAFWGDGGDG---------------------------------KGLNHLGEILMNVRAELRH  161  28899861   bacteria>proteobacteria>gammaproteobacteria
    VSWAT3_18363_Vbac_148975384          8    AEEVLFYEPE------DPNGYLSNFAA----CPIKVDG---------------QVWATSEHYYQAMK---F-----------------SSPSLRNMILEA------CTPAEAFSLSRQYE-------------------EQVREDW-----------YDIRVEVMRFIVTEKFTQ--------------------------NPQFALFLTST------GDSVIKEHSHK--------DHFWGDGGDG---------------------------------TGENHLGKILMAVRQQLRS  152  148975384  bacteria>proteobacteria>gammaproteobacteria
    GobsU_010100009074_Gobs_168699662    6    PRVINFYSVA------AEYGCFSNFSR----HPVFLRG---------------KRWPTTEHFFQAMK---F-----------------EGTEHEEQVRLA------KRPMDAASMGRDRK-------------------RPLRRDW-----------ESVKERIMMDGLRAKFTQ--------------------------HEELKAVLLGT------GDATLVEQTAN--------DSYWGDGGDG---------------------------------SGKNRLGYLLMRLREELRA  150  168699662  bacteria>planctomycetes
    HCH_06997_Hche_83649602              4    KKTINFYLAN------GEYGCFSNFSR----DPVYLKD---------------KRWPTSEHYFQAQK---F-----------------AGTEHEEAVRMA------SKPMEAANMGRERT-------------------RPLRPDW-----------EAVKDDIMREAVMAKFVQ--------------------------HEKLTSILLGT------GDAELVEHTAN--------DRYWADGGDG---------------------------------SGLNMLGKILMEVREAIQQ  148  83649602   bacteria>proteobacteria>gammaproteobacteria
    sce3364_Scel_162451636               1    MTVIRFYRSG------DAHGFFSNFSR----HPVTLKG---------------KVWPTSEHYFQAQK---F-----------------PGTEHEEVIRNA------PGPGEAARMGRQRS-------------------RPLRPDW-----------EQVKDDVMREVVLAKFTQ--------------------------HEDLRRALLDT------GDAELVEHTAN--------DAYWADGGDG---------------------------------SGRNMLGVILMEVRAQLRR  145  162451636  bacteria>proteobacteria>deltaproteobacteria
    M23134_02266_Mmar_124004851          2    DNLIKFYSIG------APYGEFSNFAP----YPIKLKG---------------KVWATTEHYFQAQK---F-----------------VGTPHETKIRKA------ASPMKAAELGRTRK-------------------VRIRDNW-----------DHIKDNVMMEAVKAKFTQ--------------------------HADLQTLLLDT------GGATLIEHTEN--------DAYWGDGGDG---------------------------------KGKNRLGKILMKVREELKD  146  124004851  bacteria
    PM8797T_20343_Pmar_149175186         5    NQPVLFYSVS------EAYGEFSNFAE----YPIQVDG---------------KRWPTSEHYFQAQK---F-----------------TEVQHREAIRKA------PSPMQAARMGRDRK-------------------RPLRKDW-----------ESVKVAVMRTAVLSKFAQ--------------------------YEKLCMLLIST------GQRKIVEHTTN--------DSYWGDGGDG---------------------------------SGKNMLGRILMEVRSQLRE  149  149175186  bacteria>planctomycetes
    HCH_04109_Hche_83646809              18   VEVIKFYSVN------DEFGEFSNFAQ----YPIKLKG---------------KVWPSSEHYFQAMK---F-----------------EEEKDRSDIRKA------KSPLEAARKGRDRK-------------------RKLRNDW-----------ESVKLNIMREAILAKFTQ--------------------------HDALRERLLST------GSAKIVEHTDN--------DDYWGDGGDG---------------------------------SGQNMLGRILEEVRAQLSE  162  83646809   bacteria>proteobacteria>gammaproteobacteria
    _Rbal_32471506                       31   SDPIKFYSTG------DEHGEFSNFAG----YPIKIGK---------------KVWPTSEHYFQAMK---F-----------------QEGSDQEEIRKA------NSPMQAARMGRDRK-------------------RKLRRDW-----------ESVKVNIMREAILAKFTQ--------------------------HEDLRELLLAT------GDAKIIEHTTN--------DDYWGDGGDG---------------------------------RGKNMLGRILMDTRTKLRE  175  32471506   bacteria>planctomycetes
    YbiA.2b3w_Ecol_82407990              14   DTIINFYSTS------DDYGDFSNFAA----WPIKVDG---------------KTWPTSEHYFQAQK---F-----------------LDEKYREEIRRV------SSPMVAARMGRDRS-------------------KPLRKNW-----------ESVKEQVMRKALRAKFEQ--------------------------HAELRALLLAT------APAKLVEHTEN--------DAYWGDGGHG---------------------------------KGKNRLGYLLMELREQLAI  158  82407990   bacteria>proteobacteria>gammaproteobacteria
    VspiD_010100021915_Vspi_171913880    1    MEPILFYSTK------GTYGAFSNFSA----HPFVLNN---------------KRWPTTEHYFQAQK---F-----------------VGTEHEEAIRMI------ASPMVAARMGRSRQ-------------------RPLRKDW-----------DSAKDDVMRKALRAKFTQ--------------------------HQDLQSLLLST------GEAQLIEHTKN--------DSYWADGGDG---------------------------------SGKNRLGILLMELRDRLRS  145  171913880  bacteria
    Namu_1431_Nmul_258651665             1    MRIIEFYLHT------DPWGELSNFHP----APIHLDG---------------QRWPTTEHYFQAAK---F-----------------PGTPHAELIRLA------ATPDRAKQLGGDRA-------------------APLRADW-----------LAVRDEVMRTALRAKFTQ--------------------------HEQLRALLLDT------ADAQLVEHTVN--------DHYCGDGGDG---------------------------------SGVNRLGLLLMQVRAELS-  144  258651665  bacteria>actinobacteria
    TTHERM_00486130_Tthe_118401008       12   NGHIYFYREY------EHNGIFSNFYA----SPIALKE---------------KQWPTTEHYFQAQK---F-----------------SGTEKEELIRLA------STPSESFKLGRQRD-----------------DEYPLRKDW-----------ESVKDEVMYEALKAKFTQ--------------------------HKDLQKFLLST------GDAKIIEHTQK--------DKYWADGGDG---------------------------------SGKNMLGILLMNLRNELKA  158  118401008  eukaryota>alveolata>ciliophora
    TTHERM_00289300_Tthe_118370894       18   GNTIKFYGAK------NKNGLFSNFYI----SPIKLKG---------------KIWQTTEHYFQAQK---F-----------------AGTVKEEQVRNA------SGPGIAFRLGRKKS-----------------NDYPLRSDW-----------LKVKDDVMYEAIKAKFTQ--------------------------HDNLKKILLST------KNHKLIEHTKR--------DAYWGDGGDG---------------------------------KGKNMLGILLMKLRKELSE  164  118370894  eukaryota>alveolata>ciliophora
    PTSG_01145_Ssp._326434983            1    MGAIRFYGHT------KPFGFMSNFYP----AKVVIDG---------------HTWPTTEHYFQAMK---F-----------------HDKDYQAQIRKY------SSPSTAKKLGQTRA-------------------VKLRSDW-----------EDVKYDVMYKACLAKFTQ--------------------------HADLRKQLLDT------GDAKLIEHTRN--------DRVWGDGGDG---------------------------------TGQNKLGQVLMEVRRELRE  145  326434983  eukaryota>choanoflagellida
    PPL_02864_Ppal_281209628             3    RPTIYFYRAA------DAYGCFSNFSD----HPVMMDG---------------YIWPTSEHYYQAMK---FKT---------------TDIEYYHQIRDA------ESPARSFKMGNTYA-------------------HDKRRDW-----------NQIKDQVMYDVVLNKFLQ--------------------------NKDIQRN---T------GISKIVEHTRC--------DDYWGDGSDG---------------------------------NGRNQLGKTLELVREFIKN  146  281209628  eukaryota>amoebozoa>mycetozoa>dictyosteliida
    DDB_G0281625_Ddis_66812724           4    NNIISFYRST------DAYGCFTNFSW----FKVHFKN---------------HTFKTSEHAFQAFK---FE----------------HEQKIFFQILNS------KTASESKRIAHLNN-------------------DKKRKDW-----------ETIKDQIMYEICFEKFNQ--------------------------NDHLKLILLDT------GNLKIVESSEK--------DFYWGIG-DG---------------------------------SGRNQLGITLMKIREDLRK  148  66812724   eukaryota>amoebozoa>mycetozoa>dictyosteliida
    DICPUDRAFT_85573_Dpur_330846708      3    DNVINFYRAG------SGYGCFSNFSR----HTVFYKG---------------QKWPTSEHAFQAMK---F-----------------EGTDHFLNVLKT------KTPGDAAKMGRNRS-------------------LPLRKDW-----------EGVKDEIMYEVCLAKFQQ--------------------------HQDIQLTLIET------NDAKLVEHTTN--------DSYWGDGGDG---------------------------------SGRNQLGITLMRVRETIRN  147  330846708  eukaryota>amoebozoa>mycetozoa>dictyosteliida
    DDB_G0283925_Ddis_66810169           5    EHVINFYRPN-----EIPYGPFSNFSR----HTVFYNN---------------VLAKTSEHIFQAMK---F-----------------EGTQHFNDVLNT------KTPGDSAKMGRDRK-------------------RPLRKDW-----------EGVKDELMYEICLAKFSQ--------------------------HKDIQKILLET------GDATLVEHTGN--------DSYWGDGGDG---------------------------------SGRNQLGKTLMRVRETIKN  150  66810169   eukaryota>amoebozoa>mycetozoa>dictyosteliida
    FP2309_Fpsy_150026339                10   MNIIKFYKVN------EPYGFFSNFSP----HPIYINN---------------ERWNSVEHYFQASK---F-----------------DNIEIREKIQAI------ESPMQVAIEGRDKK-------------------NIIRDDW-----------EMVKEEIMYSALLCKFYQ--------------------------HPKLMKELLLT------KDSLIIEHTKN--------DNYWGDGGDG---------------------------------KGKNRLGLLLMKVREEIAK  154  150026339  bacteria
    PaecuDRAFT_4172_Pcur_304407843       1    MTQIKFYETN------KPYGCFSNFSK----HPIELNN---------------KRWATVEHYFQAMK---F-----------------ENTSFEEEIRLL------RTPMEAAIAGRDRN-------------------KPLRKDW-----------EEMKEIIMRRAIEAKCEQ--------------------------HESVRDILVST------GNCLLIEHTKN--------DSYWADGGDG---------------------------------SGQNKLGQLLMEVRSEQPE  145  304407843  bacteria>firmicutes
    XNC1_2895_Xnem_300723771             4    IDVIKFYRTN------DPYGCFSNFSK----YGFLGEDD--------------FFWPTVEHYFQAKK---F-----------------IDENTQENIRLL------NSPMDAATAGRDRK-------------------KPLRPDW-----------EVIKDDIMRFAVLEKFKQ--------------------------NLDIQNILLST------HNAQLIEHTSN--------DFYWADGGDG---------------------------------SGNNMLGIILMETREILQK  149  300723771  bacteria>proteobacteria>gammaproteobacteria
    ybiA_Rden_311112847                  5    MTEIKFYRVN------DAYGYLSNFAP----YPFEING---------------LIWSTSEHYFQAQK---F-----------------LDKAIQEKIRRL------KSPMDAALEGRNRE-------------------NPLRSDW-----------EVVKDDIMRLAVFEKFRQ--------------------------NPAIRRELLAT------GHATLIEHTKN--------DNYWADNGDG---------------------------------TGKNMLGIILMETRKRLKA  149  311112847  bacteria>actinobacteria
    ybiA_Spar_296876279                  1    MKEIKFYKVH------DEYGFMSNFAP----YPFSDGS---------------KIWPTSEHYFQAQK---F-----------------LVPEIQEKIRQI------ASPMDAALEGRNRQ-------------------NPLRSDW-----------EEVKDEVMHQALRMKFRQ--------------------------NPDIAKELLAT------GDAIIIEHTQN--------DAYWADGGDG---------------------------------SGNNKLGLLLMHVRQELKN  145  296876279  bacteria>firmicutes
    ybiA_Ssan_325693558                  1    MKEIKFYKVN------DAYGYMSNFAP----YPFSDGN---------------KIWPTSEHYFQAQK---F-----------------LVPEIQEKIRLL------ESPMDAALEGRNRH-------------------NPLRKDW-----------EDVKDDIMRYAVREKFRQ--------------------------NTVIMEDLLET------GDSIIIEHTKN--------DSYWADGGDG---------------------------------TGKNMLGKILMEVRAELR-  144  325693558  bacteria>firmicutes
    CORMATOL_00583_Cmat_225020576        1    MNEIRFYRAH------DDYGFLSNFAA----YPFELDG---------------KRWPTSEHYFQAMK---F-----------------LNPETQNLIRSL------DTPGRAAKVGR-RE-------------------KPLRKDW-----------ESVKDQVMFDAVLAKFTQ--------------------------NPDIARKLLST------GDAYLIEHTKN--------DFYWADGSDG---------------------------------SGKNRLGEVLMAVRDSLRA  144  225020576  bacteria>actinobacteria
    Deima_1776_Dmar_320334379            1    MKAIRFYRQG------DAYGTFSNFSA----HPIHVDG---------------VTWPTTEHYFQAQK---F-----------------LDPELQAMIRAL------PTAGDAAKTGRRRD-------------------LPLRADW-----------EAVKEDVMRTALHAKFTQ--------------------------HEDARTLLLST------GDASLIEHTRN--------DTYWADGGDG---------------------------------HGLNRLGLLLMDLRAALRH  145  320334379  bacteria>deinococci
    AM1_2731_Amar_158335874              1    -MTIFFYKVQ------DPYGCFSNFSL----HSIDLQG---------------QTWPTSEHYYQAQK---YQGT--------------PHQALCDKIRQA------STPEAAAALGRNPL-------------------YTEQADW-----------DVIKPEIMYAAVRTKFLT--------------------------HPTIQAELLST------GDELIVENSPL--------DPYWGCGADG---------------------------------KGQNQLGKILMQVRQEIRQ  147  158335874  bacteria>cyanobacteria
    MC7420_6514_Mcht_254412559           1    -MTIYFYKVE------EPYGCFSNFSP----HPIQIDG---------------WCWQTVEHYYQAHK---FVGT--------------TDEALIRTIKNV------STPMEAALLGRDRT-------------------RNHRPDW-----------EQVKQQIMWRGVLTKFLT--------------------------HPDIQQILLNT------GEDVIVEDSPT--------DYYWGCGEDQ---------------------------------TGENHLGKMLMNVRQHIRQ  147  254412559  bacteria>cyanobacteria
    all5029_Ana_17232521                 1    -MTIYFYKVW------QPYGCFSNFSP----HSIEIQG---------------TYWLTVEHYYQAQK---FVGS--------------VDAAIIPAIRAS------KTPEEAAALGRCTS-------------------RQLRQDW-----------DLVKTIVMREAVLKKFLT--------------------------HTDIREILLST------GNEILVEDSSC--------DYFWGCGADK---------------------------------TGQNHLGKILMSVREEIRK  147  17232521   bacteria>cyanobacteria
    N9414_00365_Nspu_119509756           1    -MTIYFYKVW------QPYGCFSNFSP----HGIQIHG---------------TYWSTVEHYYQAQK---FVGT--------------VDAVIIPVIHAA------ETPEEAAALGRCRT-------------------RQLRPDW-----------EMVKTKVMREAVLNKFLS--------------------------HLEIKDILLST------GNETLVENSPN--------DYFWGCGAEK---------------------------------TGQNHLGKILMGVRAEIRK  147  119509756  bacteria>cyanobacteria
    CRD_01664_Rbro_282897552             1    -MTIYFYKVW------EPYGCFSNFSP----HPIEIHG---------------VYWATVEHYYQAQK---FVHT--------------EDNVIIPLIRSA------PTPEMAAALGRCET-------------------RKSRPDW-----------NLIKIDVMKTAVWQKFLS--------------------------HQEIQEVLLGT------GDETLVENSPI--------DYFWGCGADK---------------------------------TGENHLGKILMGIRNQIRF  147  282897552  bacteria>cyanobacteria
    OSCI_3190004_Osp._300866977          1    -MTIYFYKVE------EPYGCFSNFSP----HSIYLNG---------------QDWLTVEHYYQAQK---FVGS--------------VDEQLIYLIHAS------ETPQQAAKLGREPS-------------------RQLRPDW-----------EEVKTEIMREAVLTKFIT--------------------------HSDIQAILLST------GDRLIVEDSPT--------DYYWGCGCDR---------------------------------TGQNHLGKILMSVRLEISQ  147  300866977  bacteria>cyanobacteria
    SYNPCC7002_A1948_Syn_170078553       7    -EPIYFYKAH------DPYGCFSNFSL----HPIHCEA---------------LDWPTVEHFYQAHK---FLPT--------------HQQDLIDKIRAA------STPEIAAALGRDPQ-------------------HPKRPDW-----------EDIKRTVMWQGVWTKFKT--------------------------HPDIAQILLAT------GDAAIIENSPV--------DYYWGCGADG---------------------------------SGRNYLGKVLMRVRSQLRQ  153  170078553  bacteria>cyanobacteria
    tlr2465_Telo_22300007                1    -MTIYFYRVK------DAYGSFSNFSP----HGFTLEG---------------YYWPTAEHYYQAHK---FFGT--------------PYEAFGHAIRIA------PTPEAAAQLGRSGR-------------------YPVHPQW-----------DQLKQAVMWRALVAKFTT--------------------------HAELRELLLAT------VDEELVEDSPV--------DSYWGCGGDR---------------------------------QGSNYLGRLLMHLRHCLRQ  147  22300007   bacteria>cyanobacteria
    Cyan7425_0270_Csp._220905714         1    -MVIYFYKVE------GPYGCFSNFSP----HGFELEG---------------QRWQTVEHYYQAHK---FVGT--------------PDHHLCTQIQQC------QTPAQAAALGRNPC-------------------HCPRSDW-----------EEIKQQVMRTAVLAKFKT--------------------------HPQIRTILLET------GEAWLVEDSPV--------DFYWGCGADR---------------------------------SGQNHLGRILMSVRQELRS  147  220905714  bacteria>cyanobacteria
    _Krac_298249651                      1    -MTIYFYTAR-----EEPYGCFSNFSR----HGIDLDG---------------AWWPTVEHYFQAQK---F-----------------AGTPYANKIRIA------FTPKQAADLGRSRQ-------------------HPLRPDW-----------EQVKDEIMLKAVRRKFEL--------------------------HTQLRKLLLAT------GSEELIENAPS--------DYYWGCGSDG---------------------------------SGQNKLGQLLMRVRLELSS  145  298249651  bacteria>chloroflexi
    Tery_2448_Tery_113476072             1    -MTIYFFDET-----EQPYGCFSNFSP----HGFELDG---------------LWWPTSEHYFQAQK---F-----------------LGVQHLEEIRWA------KTPAGAAKMGRERS-------------------RPLRKDW-----------EEIKEDVMERGLLCKFQS--------------------------HKDIGEILLST------KDELIVENAPE--------DYYWGCGKDG---------------------------------SGKNRLGEILMKVRNRLQN  145  113476072  bacteria>cyanobacteria
    Cyan7822_3925_Csp._307153746         1    -MAIYFYSTR-----EQPYGCFSNFSQ----HGFELEG---------------FWWPTSEHYFQAQK---F-----------------PNHPWQDQIRKA------KTPKDAAKMGRDRR-------------------YPLRSDW-----------EEIKDEIMKRAVWQKFTT--------------------------HADIREILLQT------GDELIVENSPI--------DYYWGCGADG---------------------------------TGKNRLGEILMAVREILRA  145  307153746  bacteria>cyanobacteria
    L8106_12950_Lsp._119486659           1    -MTIYFYSSR-----EEQYGCFSNFSY----HGFVLDE---------------LWWPTNEHYFQAQK---FVS---------------TDPEWFTKIQTA------KTPAQSARMGRSRE-------------------HPLRSDW-----------EEVKDEIMQKVVLCKFQT--------------------------HADIREILLST------GDEFIVENSPI--------DYYWGCGQDG---------------------------------SGKNKLGEILMAVREILRQ  147  119486659  bacteria>cyanobacteria
    MC7420_678_Mcht_254413191            24   -MPVYFYSTR-----EKPYGCFSNFSR----HGFELDG---------------CWWATSEHYFQAQK---FVE---------------TDHPWFDKIREV------KTPKDAAKMGRSRE-------------------HPIRSDW-----------EQVKDEIMKRGVLQKFET--------------------------HADIREILLAT------GDELIVENSPS--------DYYWGCGKDG---------------------------------SGKNRLGEILMAVREILCQ  170  254413191  bacteria>cyanobacteria
    ybiA_Osp._300869472                  1    -MTIYFYSTR-----EEPYGCFSNFSA----HGFELEG---------------VYWLTSEHYFQAQK---F-----------------VGTPHVEQIRQV------KTPKDAAKMGRERK-------------------RPLRQDW-----------EEVKDDIMRKAVLCKFET--------------------------HANIREVLLST------GDEEIVENSPI--------DYYWGCGKDG---------------------------------SGKNKLGLILMEVREILRQ  145  300869472  bacteria>cyanobacteria
    Haur_0354_Haur_159896886             1    -MTIYFYAVS------AEFGCFSNFSA----HGFKLDG---------------HYWPTSEHYFQAQK---F-----------------TGTDYATTIRLA------KSPAIAARLGRSRK-------------------QPLRRDW-----------EAIKDAVMRRALLAKFRS--------------------------HAEIRAILLAT------DDQPLVENAPN--------DYYWGCGIDG---------------------------------SGKNMLGQLLVEIRQTLRD  144  159896886  bacteria>chloroflexi
    AM1_3712_Amar_158336844              1    -MAIYFYSSR-----EKPYGCFSNFSA----HGLTLDG---------------VWWPTSEHYFQAQK---F-----------------VGTPHADQIRQV------KLPKDAARLGRQRT-------------------RPLRPDW-----------EAVKDDVMRQAVLCKFET--------------------------HADIQDILLST------GNQDLVENAPG--------DYYWGCGQNG---------------------------------TGKNMLGKILMEVRERLRA  145  158336844  bacteria>cyanobacteria
    PM8797T_29763_Pmar_149176205         1    -MTIYFYTK------NDTYGEFSNFSP----HGVERDG---------------LWWPTVEHYFQAQK---F-----------------AEADYRERIRNA------HNAKQAANLGRSRK-------------------IPLRADW-----------EEVKDEIMYQGVLQKFQT--------------------------HAELKILLLST------GDQEIVENAPG--------DYYWGCGKEG---------------------------------TGLNRLGEILVRVRGELRE  144  149176205  bacteria>planctomycetes
    TM1040_1897_Rsp._99081738            6    PDTIYFYAQ------TDPYAEFSNFAP----YGVCFED---------------IWWPTVEHYFQAMK---F-----------------HDAAYRTRIRRC------QKPKDAKALGMTRK-------------------IPLRADW-----------EEVKDDIMYAAVLCKFRT--------------------------HGAPRQLLLGT------GDAPLVENAPM--------DAYWGCGPDG---------------------------------LGLNKLGRILMRVRGELAE  150  99081738   bacteria>proteobacteria>alphaproteobacteria
    Jann_2797_Jsp._89055288              6    LNTIYFYAQ------TDAYAEFSNFAP----FGVEMEG---------------VYWRTVEHYFQAMK---F-----------------DDATHRERIRTA------RKPKDAKASGMTRA-------------------VALRADW-----------DEVKDAIMQAAVFRKFQT--------------------------HAVPRDLLLGT------GSAQIVENAPM--------DAYWGCGPDG---------------------------------RGLNKLGRILMDVRDSLAS  150  89055288   bacteria>proteobacteria>alphaproteobacteria
    SCH4B_1850_Sisp_259416444            5    PEPIYFYAQ------TDPYAEFSNFAP----YGVAFEG---------------TWWRTVEHYFQAMK---F-----------------HDADHRERIRRC------HKPKAAKALGMTRA-------------------IPLRADW-----------EEVKDGIMLTAVRCKFQT--------------------------HAAPRQLLLST------GDAPLIENAPM--------DAYWGCGPDG---------------------------------RGLNKLGQILMTVRSKLSG  149  259416444  bacteria>proteobacteria>alphaproteobacteria
    Sde_0405_Sdeg_90020054               9    EKALSFSR-------FDASHWLSPCVL----RPFQLDG---------------HTWPTAEHYLQANL---V-----------------ASAALADKIRQA------ASGEQAHALGSPWY-------------------RRKRKDW-----------KNLRRVLMTRALYTQTMT--------------------------HPDIKDALLET------GDQHIVETSLY--------DHYWGIARDQ---------------------------------RGENILGKVWMGVRDKIRA  152  90020054   bacteria>proteobacteria>gammaproteobacteria
    TERTU_3943_Ttur_254787804            9    ENAVRFSR-------FDPESLFSTVSA----HPLELEA---------------EVWPSAEHYFQAQL---A-----------------GSDSWREKIKAA------PTPAQAYKLGCVWY-------------------KRKVRGW-----------KNLRRVMMTRALYTKVQM--------------------------YPAVRDALLST------GDETILETSLY--------DHYWGIGRDQ---------------------------------RGDNMLGKVWMDIRRKLRE  152  254787804  bacteria>proteobacteria>gammaproteobacteria
    HP15_2779_Mbac_311695670             10   ENDLFMSR-------TDPENPLGTHAP----YSFELEG---------------KIWPTVEHYFQGMK---F-----------------TDDNRQEKVRSA------DTPGKAGKLGRKRH-------------------KSLRRDW-----------KQVRETVMTRGIYVRCRT--------------------------HPELAEALLDT------GDTKIVENSNF--------DYFWGCGRDR---------------------------------RGENRYGKVLMNVRARLRE  153  311695670  bacteria>proteobacteria>gammaproteobacteria
    RED65_02704_Bmar_94501287            9    EDAIFFSR-------LDEEEMLGSRIH----QPFLLDD---------------YNWPTAEHYTQALL---F-----------------KDAKIQQQIRES------EEPVEAAKQYKWRF-------------------WLKHKDW-----------KKRGPILMTRAIYTQCKT--------------------------YPVKAQALLDT------EDRLLMENSLY--------DYFWGCGRDR---------------------------------RGDNRYGKVMMSVRGRLRK  152  94501287   bacteria>proteobacteria>gammaproteobacteria
    GP2143_10137_Mgam_119476904          11   QDAMYFTR-------SDVNEDFGSFSK----HPFQLED---------------KEWPSVEHYYQAMK---F-----------------DDQAYQETIRCA------DHPKKARKLGRNRF-------------------RSIRKDW-----------RDVKVVYMTRAVYTMCRT--------------------------YPDIATKLLTT------GSNRLVENSQY--------DYFWGCGRDR---------------------------------RGDNHFGKVLMNVRDKLHT  154  119476904  bacteria>proteobacteria>gammaproteobacteria
    SCHCODRAFT_258660_Scom_302674850     60   RPQIFFYDR------DKPHYGFTNFSP----HPVKYKD---------------AIYPTSEHLFQAFK---FME---------------HQPQLAEHIRRQ------PRPRDALSEARRFD-------------------NEKRRDW-----------FKVNIDKMDEALHLKFTQ--------------------------HKDLQEELLST------GSAELIEDSPV--------DAFWGIGKDG---------------------------------RGRNELGKALGRLRKKLKR  206  302674850  eukaryota>fungi>basidiomycota
    LACBIDRAFT_318005_Lbic_170095960     159  RPRILFYNK------SDPHYGFTNFSA----HSVVYKG---------------KRYPTSEHLFQSFK---FQK---------------HRPNLAEHIRTCS-----ERPSVAFSEARRFQ-------------------PEVRTDW-----------KQVNIEKMDEALWCKFTQ--------------------------HSDLKAELLST------GDAELVEDSDK--------DAFWGVGADR---------------------------------RGRNELGKALERLRAKLRE  306  170095960  eukaryota>fungi>basidiomycota
    LACBIDRAFT_316770_Lbic_170117768     78   PSPIFFYHK------HDLHYGFTNFSD----HPVCYER---------------EMYPTSEHLFQSFK---FLP---------------HRPDLAKHIRSC------SCPSDALAKARRFK-------------------AYVRPDW-----------RRINIQIMDQVLLLKFTQ--------------------------HQDLKDELLAT------GNAELIEDSYK--------DSFWGVGADG---------------------------------QGRNELGKALMDLQDKLHR  224  170117768  eukaryota>fungi>basidiomycota
    SCHCODRAFT_258659_Scom_302674848     103  AQRILFYHK------HDPHYGFTNFSD----HPVKYQG---------------KVYPTSEHLFQALK---FMP---------------HKSQVAEHIRTSS-----PSPRAAFTEAHRYQ-------------------SEVRKDW-----------SKVNVKMMEIALEHKFDQ--------------------------HPALREELLAT------GEAELVEDSAQ--------DAFWGVGPNG---------------------------------KGRNELGKALMRLRTQLRQ  250  302674848  eukaryota>fungi>basidiomycota
    MGL_3049_Mglo_164657874              61   TNKIEFFSK------DLPFFWLNNASD----HPVVLDG---------------VRYPTAEHLFQAQK---FID---------------HRPDIANKIRKA------SNAVEAIHIARTFS-------------------RDVRADW---------IKDGVNVSTMRMVLLTKFMQ--------------------------YSDLRLALLET------GDAEIVHASPN--------DAFWGSAAAP-----------------------------NSVGRGRNMLGRTIMQTRE-LLR  212  164657874  eukaryota>fungi>basidiomycota
    SCHCODRAFT_36431_Scom_302693411      1    --QIRFCNR------DTSYNSFCNFAR----YSVAYNG---------------ETYPTAEHLFHASK---FLP---------------VNGDIARRIRNT------KDVGEVARLADRFQ-------------------ARVPQEW-----------WNNMVETMHGILLDKFLQ--------------------------HEDLQAALLST------GDAELVFDSVE--------DGFWGVDKDE---------------------------------TGNNILGRTLERVREELR-  144  302693411  eukaryota>fungi>basidiomycota
    HMPREF9488_03196_Csp._319937960      7    KIIDSFHG---------EYAFLSNYYD----SPIFYDG---------------ILYPTVEHAFQAAK---T-----------------TVFIQRIIIANK------KTPGQAKCAGRKV---------------------TLRDNW-----------DDIKLYIMKELIILKF-T--------------------------NPKLKSALLNT------KDAELIERNTWN-------DTYWGICN-G---------------------------------IGENHLGKILMEVREMLRG  145  319937960  bacteria>firmicutes
    mru_1967_Mrum_288561223              3    DEIDRFDG---------KYLFLSNFYI----CDVEYDG---------------ILYPHTEAAFHAQK---V-----------------FDDETKMKFTNV-------TPKQSKRLGRKV---------------------KLREDW-----------NEVKDNIMYEVCKAKFEQ--------------------------NPDIRKLLLET------GDATLIEGNTWN-------DQYWGVCR-G---------------------------------KGRNQLGKTLMRIREELRE  141  288561223  archaea>euryarchaeota
    DORFOR_01894_Dfor_166032191          27   TQINEFRG---------DYAFLSNFYP----APVSYMG---------------QTYANNEAAFQAQK---T-----------------LSAREQRKFCIFRM----HNPSDAKKLGRDL---------------------TLRPDW-----------EKVKVRLMYEICMCKFMQ--------------------------NPELRDKLLAT------GESTLIEGNNWG-------DYFWGKVN-N---------------------------------CGENQLGIILMDVRAKLQW  168  166032191  bacteria>firmicutes
    RUMGNA_01423_Rgna_154503599          12   QTIDHFHG---------AYAFLSNFYP----SRIYYRG---------------YWYANNEAAFQAQK---T-----------------ISPKEQLQFTKL------RNPKDAKKLGREV---------------------QLRSDW-----------ESVKLMYMYEICMCKFMQ--------------------------NPTLCKALLAT------GNCHLVEGNNWG-------DYFWGSVN-G---------------------------------HGENHLGKILMDIRAKLQF  151  154503599  bacteria>firmicutes
    CCU_25310_Csp._295094771             3    TTINSFRG---------DYFFLSNFYE----CPVTYQG---------------ITYPNNETAFQAQK---C-----------------INDSDKTKFISL-------NPSAAKKLGRRV---------------------ALRKDW-----------ESIKFSVMKNLVKAKFTQ--------------------------NPDLAEKLLAT------DNAHLEEGNTWG-------DRIWGTVN-G---------------------------------TGANKLGIILMQVRDELNL  141  295094771  bacteria>firmicutes
    Rumal_1634_Ralb_317056301            1    -MIDRFTD---------EYFFLSNFYE----SKVTFEG---------------ITYLNNEAAFQAMK---T-----------------LDESERRSFAGL-------DPDSAKRAGRKV---------------------SLRSDW-----------EEVKTDLMYEICKAKFTQ--------------------------NKDLAEKLLAT------GGEELVEGNDWN-------DRIWGKVN-G---------------------------------QGENRLGIIFMKVREELRL  138  317056301  bacteria>firmicutes
    nadE_Ralb_325680741                  1    -MIDSFKG---------DYCFLSNFYE----AKVTYEG---------------ITYLNNEAAFQSIK---T-----------------TDMAKRRDFADL-------DPAEAKKAGRNV---------------------SLRGDW-----------EDIKINVMYKICKAKFTQ--------------------------NSDIAEKLLAT------GDEELVEGNDHG-------DKIWGKVN-G---------------------------------EGANNLGKILMRVREELKM  138  325680741  bacteria>firmicutes
    99_BPphiW-14_282599036               1    -MIDNFKT--------PETEWLSNMYP----CRVLYEG---------------VVYPSAEHAYAAQK---A-----------------VDWLDREEIAQA------KTGYLAKQMGAAV---------------------QKRADW-----------DQVKMRVMLEVLRAKFFN--------------------------NDFLGDKLLAT------GSQELVEGNWWH-------DTFWGVCE-G---------------------------------VGENHLGKLLMQVRRELEA  140  282599036  dsdna viruses, no rna stage>caudovirales
    Pmar_PMAR024558_Pmar_294875527       18   NVIRAFRG---------EFGFLSNFSD----DPVRMDDG--------------ILYPTAEHAFQAQK---V-----------------VDVEKRRCMVEKC-----GTAKSAKAWGKRAK--------------------PLRADW-----------NDIRVDVMREVIGAKFKGG-------------------------SEELREMLVAT------GERELVEGNVWN-------DTFWGVSLRT--------------------------------GKGQNQLGKILMEVREELKK  163  294875527  eukaryota>alveolata
    _BP1_308516893                       13   KPIMGFQG---------EYRWLSNFWT----APIVVTG---------------FEYQNTEAAYQAAK---T-----------------INVAHRMQFKNM-------TGGEAKRAGRSV---------------------IMRHDW-----------DFVKLEIMELVLRAKFMA--------------------------HADLALKLIET------GDRDIVELNTWG-------DTHWGQIKDK-----------------------------EGNLVGENVLGKLLMNIRSDINK  156  308516893  dsdna viruses, no rna stage>caudovirales
    Mpe_B0288_Mpet_124262828             3    AAPISFYRAS-----ERPFGAFSNLFR----REILIAG---------------RTFATTEHAYQALK---P-----------------RDARVRDWLLAA------PAPSLLAIAAHTLPSESADPTEIMARTADALLGFHTRPGW-----------SRLRFPWMLRCLDAKFDQ--------------------------HPDLAELLLST------GDSAIIEAGRIDDDA----GRRWGIVN-G---------------------------------RGSNYLGRMLQRVRHRLGG  170  124262828  bacteria>proteobacteria>betaproteobacteria
    bgla_2p0770_Bgla_330822167           19   LNEIRFYRAN-----EKPYGAFSNLYK----RPIEFEG---------------VTYPTSEHAYQAGK---A-----------------VKPAVRQWILSA------PTPALAAMAAHGLY------------------VWDVVPDW-----------AQIKFDRMRAVLRAKFDQ--------------------------HADLRELLLST------GEARLVEAGTVNNAV----NRLWGEVD-G---------------------------------KGENMLGVMLMELRAAYAK  168  330822167  bacteria>proteobacteria>betaproteobacteria
    PSPA7_3050_Paer_152987782            1    MQEIRFYRAN-----EKPYGAFSNLYK----REVLFEG---------------VVYPTSEHAYQAGK---P-----------------RKEAVRDWILSA------PSPALVAMAAHGLY------------------WWDIRPGW-----------SKIKFDRMRAILLAKFTQ--------------------------HEDLKALLLST------EQARLVESATVDNEV----NRTWGEVN-G---------------------------------KGKNMLGVLLMEVREELLH  150  152987782  bacteria>proteobacteria>gammaproteobacteria
    Tgr7_1771_Tsp._220934941             20   KESAVFYKTK------ETFGALSNMAS---GYPLRVNC---------------VRILTSEALYQACR---FP----------------HLPEVQRVIIDQ------KSPIAAKMKSKPHR-------------------KDSRPDW-----------DQVRVGVMRWCLRVKLAQ-------------------------NYKEFGRWLLVT------KDKEIVEQSKK--------DAFWGAKVID---------------------------DDGEILVGQNVLGRLLMELRELYRN  173  220934941  bacteria>proteobacteria>gammaproteobacteria
    GSTUM_00011304001_Tmel_296424705     50   TGPVYFWKPH-----EVPFGIFSQWYE----DEFTAPFDGEQ-----------MRFGTAEQYMMYSKAVLF-----------------NDPDTAAEIMKT------MNPSTQRALGRKVR-------------------NFTDVTW-----------AENRSRIVEEGSYWKFKK--------------------------DP---SRLLET------GDREMVEASPR--------DRIWGIGFGP----------------------KNADAGKRDKW-GMNLLGKALMEARDRLRR  209  296424705  eukaryota>fungi>ascomycota
    R617_APMV_311978014                  4    DKYVFFHGAN---KNQAGVHIFSQWFP----VNFKEYLNGEE----------FAEYVSAEQYMMAHKALLF-----------------GDMFHFKKIMEC------SKQCKIKYLGRRVR-------------------NFNPTIW-----------DKHKFDIVTEGNRLKFSQ--------------------------NPDLMKRLLET------GNKTIVEASPS--------DKIWGIGLTA----------------------QQAVNIPENKWPGKNLLGKVLMKIREEN--  168  311978014  dsdna viruses, no rna stage
    Esi_0071_0113_ESV_298714411          57   EGMVLFWK---------EPACFVQWTP----CSFELDG---------------ERYCNAEQWMMASKARLF-----------------NDRTALQQIMAT------ADPRRQKALGRQVR-------------------GFDPAMW-----------DKKGYDVVVRGNLAKFKQ--------------------------NPGFRDELLAT------GDRILAEASPY--------DSEWGIGLHA----------------------NDADALIQARWPGRNKLGEALMDVRSQL--  210  298714411  eukaryota>stramenopiles
    Esi_0017_0056_ESV_298707265          134  DTMVLFWN---------PPCVFTQWEP----ALFEVDG---------------VKYCSAEQYMMACKANVF-----------------GDTDIWNKIMST------SDPAQQKRLGKEVA-------------------NYDHGIW-----------NLCKVQFVLTGNYSKFTQ--------------------------NPGMCDQLLAT------GDKMLAEASQH--------DKVWGIGMDA----------------------FDPNVERHECWRGQNLLGKILMYVRNKI--  287  298707265  eukaryota>stramenopiles
    Esi_0345_0025_ESV_298711392          58   PDLLFFWQ---------PPSVFSQWTP----SVFVVDN---------------VQYSCAEQYMMAEKAKLF-----------------GDNSSWQKIMAT------PSPREHKDLGRGVS-------------------GYDQNVW-----------DQHKMRIVARGNYAKFTQ--------------------------NEMMGQRLLDT------GEKLLAEASPY--------DRVWGIGLRA----------------------DNPAARTPSSWRGQNLLGDILQEVRTR---  210  298711392  eukaryota>stramenopiles
    NAEGRDRAFT_31328_Ngru_290996009      18   QKYEFFWK---------DKSVFSNWHA----ASYVLDG---------------IQFANTEQGMMYGKAKLF-----------------GDDEVAKDILAN------TSPSNAKQLGRMVS-------------------NFTDDMW-----------NQNRELIMKRHLYAKFSQ--------------------------NEDIKQTLLST------GDKILAEASPN--------DAIWGIGMRE----------------------HEAIETHPSKWPGLNLLGKLLTEVKQELRN  173  290996009  eukaryota>heterolobosea
    NAEGRDRAFT_36485_Ngru_290990814      20   SKFHFFWG--------TKGGYYSQWVK----APMKIDG---------------KTFVTCEQYMMYQKAQLF-----------------NDHEMAEKILKT------SDPKQCKEFGRKVK-------------------NFDTNQW-----------EANRDRIVYEGNYAKFTQ--------------------------NEEMRRDLLSR------LDVEYVEASPY--------DKIWGIGLEE----------------------KDQRAHDRSQWKGLNLLGRIITQIRDDLIN  176  290990814  eukaryota>heterolobosea
    NAEGRDRAFT_31151_Ngru_290996214      26   SKFFFFWN---------EETCFSQWVK----APMKVND---------------QTFSNCEQFMMYQKALLF-----------------NDQEIAKRILQS------TNPKNTKALGRKVS-------------------NFNEKIW-----------EDNKVRIVYEGNYAKFAQ--------------------------NDDLRKDLLSR------PDVEYVEASPY--------DKIWGIGLEE----------------------KDPRAKQRNEWQGQNLLGRIITQVRDDLMM  181  290996214  eukaryota>heterolobosea
    PRU_0345_Prum_294673111              5    DKHICFWN-----------EWPSNWHP----AEFDVEVNGV-----------KCHFYNTEQYFMYMKAIVF-----------------GDEEIAKQILEV------SDPKKVKALGRKVQ-------------------NYDEAVW-----------NEKRYQVMLKANVAKFSQ--------------------------NEDLKQLLLSPEY----EGHGFVEASPY--------DKVWGVRMFE----------------------SNPDIDDETKWKGLNLLGKVLDETRRIVSL  164  294673111  bacteria
    Fisuc_1361_Fsuc_261415758            7    DKHVFFYH-----------EWLSNFWN----APFEYKG---------------RTFFCNEQAFMWEKAVLF-----------------GDKVMEEKILVA------STPQEAKRLGRKVT-------------------PFDKEKW-----------DSVRYQVMLDINYAKYSQ--------------------------VEDCKNRLLDPEF----DGHAFVEASPR--------DRIWGIGLSV----------------------TNPNIDDPANWRGRNLLGKVITEVRDRLVQ  162  261415758  bacteria
    KgORF4_BPK_48696395                  5    REYIMFWG---------KEDIYSNFYP----IKFKHQG---------------RTFNNSEQAFMWRKARYF-----------------NDFQIAGEILNA------KNPNHAKSLGRKVR-------------------NFNEEQW-----------NKVRYNIMVEVVKDKFMT--------------------------THLKQRILDTD------VRKDFVEASPY--------DKIWGVGLKA----------------------NDPKILEQSNWKGQNLLGKVMEDVRVHCIY  160  48696395   dsdna viruses, no rna stage>caudovirales
    bgla_4p0890_Bgla_330814539           5    GNFTAFFG---------AEDVLSNWHP----SRFTYHD---------------VEFNCVEQFMMYAKAMLF-----------------DDHGTASKILTA------QSPKRQKELGRDVS-------------------GFDEQTW-----------IKSRESIVFVGCREKFRQ--------------------------NPSQGTVLSGT------GSTILVEASRS--------DKIWGAGIGQ----------------------FDSRITDPTKWPGLNLLGYTLMRVRDRPFS  160  330814539  bacteria>proteobacteria>betaproteobacteria
    bgla_3p0420_Bgla_330818849           5    NNMTLFFG---------AEDALSNWHQ----CRFEYHG---------------VAFTCVEQFMMYAKAKLF-----------------EDHATAAAILAT------TDPHKQKQLGREVK-------------------GFNDAVW-----------VEKREAIVTVGCREKFQQ--------------------------NPALRDTLLAT------GDTVLVEASPY--------DRIWGVGFAW----------------------NDPLILDPKNWRGTNLLGKTLTTVRQLLKD  160  330818849  bacteria>proteobacteria>betaproteobacteria
    Rpic12D_5003_Rpic_241589866          5    LGMTLFFG---------AEDALSNWHP----ARFTYRG---------------VEFSSVEQFMMYSKARLF-----------------NDDQTARKILSA------SEPREQKRLGREVR-------------------GFDEAVW-----------IIKRKPIVTVGCREKFWQ--------------------------NQPLGEVLLGT------DDTLLVEASPY--------DRIYGVGLAW----------------------NDPRIRDVSQWQGLNLLGEVLMEVRTWLPK  160  241589866  bacteria>proteobacteria>betaproteobacteria
    GobsU_010100015693_Gobs_168700969    3    ETFTFFWK-----------HRLSQWHR----APFVICG---------------VTFTHAEQYMMYAKALLF-----------------GDRETAGKLLAA------ETPREQQALGRAVR-------------------GFDESVW-----------VLFREGIVFAGNYARFGQ--------------------------NPDQRELLFST------RGTTLVEASPH--------DRVWGIGLSA----------------------DDPRARDRSRWLGLNLLGATLTRVREALLF  156  168700969  bacteria>planctomycetes
    M23134_00353_Mmar_124010457          5    EQFTFFWE---------TRSPLSQWHP----SDFTVDG---------------VAFNCAEQYMMYQKAKLF-----------------EDEQIAAQILRT------KKPRDQKALGRKVR-------------------NFDATTW-----------NNHCKKIVYDANYAKFTQ--------------------------NETLKASLLAT------TGTTLVEASPY--------DKIWGIGLAV----------------------DHPDVQDKSKWQGTNWLGEVLTQLRDDLIS  160  124010457  bacteria
    PPE_02438_Ppol_308069201             2    EKFTFFYR---------SHSPFSQWYP----SDFVADG---------------LEFNCAEQYMMLKKAQLF-----------------GDEEAALKIMQV------PTPREQKARGRSVR-------------------GFDQSLW-----------EGNCRQFVYDGNYAKFTQ--------------------------NPNLLKYLLKT------KGTTLVEASPT--------DTIWGVGLAE----------------------SDARIRNRKLWRGTNWLGEILTNLREDVLQ  157  308069201  bacteria>firmicutes
    AceceDRAFT_2244_Acel_303240378       2    EKFTFFWR---------SHSPFSQWYI----AKFIING---------------IEFNCAEQYMMYMKAVLF-----------------KDEEISQKILEA------KMPSQHKSLGRKVK-------------------HFNQEVW-----------ESNCKKIVYDGNYAKFTQ--------------------------NPELKQKLLET------KG-TIVEASPV--------DSIWGVGLSE----------------------DDPRIQDRKTWRGKNWLGEVLTQLRDDLLK  156  303240378  bacteria>firmicutes
    Sterm_3136_Ster_269121732            2    EKFEFFWK---------SDSPFSQWYK----KGFKVKG---------------KSFNCAEQYMMYMKAVLF-----------------GDEIIAAKILEA------KSPREQKDLGRKVK-------------------NFNKDIW-----------ERQCKNIVYNGNYAKFTQ--------------------------NEGLKSALLET------KGKTLVEASPY--------DTIWGIGLSE----------------------ENPDSKRRSKWRGKNYLGEILTQLREDILK  157  269121732  bacteria>fusobacteria
    MXAN_5330_Mxan_108762267             7    QRFTFFWQ---------AHSPFSQWHP----SDFTVDG---------------VRYVCAEQYMMAGKARLF-----------------GDNEALASILSS------KSPKTHKALGRKVR-------------------DFDNTRW-----------EKARERIVYEGNRAKFTQ--------------------------SPELLKALLAT------AGTELVEASPV--------DRIWGVGLDE----------------------EDPRILHPAKWRGLNLLGKVLTKLREDLLA  162  108762267  bacteria>proteobacteria>deltaproteobacteria
    Bresu_2709_Bsub_302383816            19   EGFHPFIK-----------GVFSQWHP----TPFAIDG---------------LSFHTAEQWMMFAKARLF-----------------ADDQQADLILAT------PDPATQKRLGQRVQ-------------------NFDQATW-----------DASKINIVYAGNRAKFEQ--------------------------NEGAYRQLKST------SGLMLVEANPR--------DWIWGAGLAI----------------------DDPCLSQPQEWRGVNLLGRILTKVRSDLS-  171  302383816  bacteria>proteobacteria>alphaproteobacteria
    C08E8.4_Cele_212646224               12   QTYVLFYE---------DESVFSNFHP----SNFEAETAKKLVNSGMFKEEEMLKFNCSEQYFMYHKALLV-----------------GDVDSAKVIITA------KHPMVMKMTGRQLN-----------------MNRHDIDNW-----------TQKSRDIMYLACLAKFSQ--------------------------NVELRKMLFRT------QDMYLVEASGN--------DAIWGNGIWK----------------------EDKRSDDVANWHGTNYLGEILDRIRGELIG  184  212646224  eukaryota>metazoa>nematoda
    T24A6.7_Cele_17564644                13   KQFVFFYK---------FDCVFSNFYP----CEFSAQEFENDVEKN-------VNFNCSEQYFMYHKALLV-----------------GDSEIAGKILKE------TDPRKMKRLGRQLS-----------------MSKKQLEEW-----------SQNSKEVMYNGCLEKFSQ--------------------------NNVCRENLFRT------HGMRLVEASPM--------DRIWGIGLSH----------------------HDKRCENEQTWRGTNWMGSVLDKVREELWT  178  17564644   eukaryota>metazoa>nematoda
    LOC588539_Spur_72168255              9    DRYTFFYG--------EKSAPFSQFRA----ANFEVDG---------------VQYTCAEMYMMHQKAVLF-----------------GDHEIAEQILLG------TKPMAMKALGRKVR-------------------NFDEEVW-----------KQNRRQIVKKGNLAKFSQ--------------------------NPDIRAELMAT------RGTTLVEASPR--------DKIWGIGMGK----------------------DNPHAKNKSKWRGQNLLGYILTEVREELEK  165  72168255   eukaryota>metazoa>echinodermata
    DR_1263_Drad_15806282                68   TEYLFFYR---------TAHPFSNFHP----SPFSASG---------------RQFHTAEQYIMHRKAEEF-----------------GDHASAKAILQA------RTPAECKALGRRVQ-------------------GFSESHW-----------AQVRGQVAFDAAWHKFRS--------------------------SRRLREFLLDT------GELILVEAAPN--------DRIWGIGYSE-----------------------QDAWEHRDQW-GENLLGQALMQVRERLRD  221  15806282   bacteria>deinococci
    Pc16g08100_Pchr_255940726            25   VDTIFFWKI------NSDFGEFSQWYR----SDFVCDD---------------EAFATAEQYMMYKKAMMF-----------------GDSNMSERILCS----SSADPRKHKSMGRKVA-------------------NFNEVIW-----------ESRNMNVAINGNYCKFAQ--------------------------NIDLMKLLLGT------GDKMIVEASPM--------DRIWGIGFDS-----------------------KLAMSNVGRW-GQNRLGKSLMTVRSMIKD  183  255940726  eukaryota>fungi>ascomycota
    FG02760.1_Gzea_46111757              7    PGPVYFWKES-----DPEAGYLSQWYY----CPFRDDK--------DER----IRYKTAEHYMMFQKAMLF-----------------KDEHTAIEVLKA------ATPRKVKALGRKVK-------------------NFNEATW-----------LKHRCDIVRHGNILKFTRAISEKGYKKGSPSG---------NPLEGSLLDTLLRT------GDRELVEASPF--------DPVWGIGFKA-----------------------ADAEAARGSW-GENLLGKELMAVRSILRK  184  46111757   eukaryota>fungi>ascomycota
    NECHADRAFT_29138_Nhae_302884348      5    SNPLYFWRET-----DPVSGYLSQWYY----CPFRDDG--------DEK----KTYKTAEHYMMHHKALLF-----------------NDEKVALQILRA------GHPREVKSLGRKVS-------------------NFDEATW-----------NAHRREIVRRGNLLKFTNAVSEEGFQKGTPAKGKSAVKRKYEPIEGSLREMLLST------GEREIVEASPF--------DRIWGIGFKA-----------------------ADAEAARESW-GQNLLGLELMEVRRILRE  191  302884348  eukaryota>fungi>ascomycota
    PMAA_059590_Pmar_212541268           10   DNPVYFWKP------EGDYGFLGQWWP----SSFSWKT-------DDEE----YTYASAEQYMMHRKALLFAG---------------PEDPITLQIQTG----WKLRPSVIRDLGRQIP-------------------NFSEEAW-----------QQNRYEIVLEGNYLKFSQ--------------------------NEELKEKLLET------GARELVEASPR--------DRIWGIGFGA-----------------------RHAGANRREW-GLNLLGKVLMETRERLVR  174  212541268  eukaryota>fungi>ascomycota
    TSTA_012120_Tsti_242799239           9    SNPVYFWRP------EGEYGFLGQWWP----SSFSWKN-------GDEE----FTYANAEQHMMHRKALLFAG---------------PSHPITHQLQKA----WKLEPGTIRDLGRQIP-------------------DFSEQMW-----------QQNRYAIVLEGNYLKFSQ--------------------------NGDLRRELLAT------EDRELVEASPR--------DRIWGVGFGA-----------------------AYASENRREW-GLNLLGKALMETRERLRR  173  242799239  eukaryota>fungi>ascomycota
    MGYG_00619_Agyp_315054313            3    SEPIFFWKP------EQEHGYLGQWWK----SDFTVPA-----EDGGKE----LKYENCEHYMMHQKGVLFA----------------PDDPVTQEILAPSG--PVPDPKTIKALGRKVP-------------------NFDDAVW-----------KKERFRIVVQGNYYKFTQ--------------------------NPELKAQLLET------GDRELVEASPR--------DRIWGVGFGA-----------------------KNAPAKRANW-GLNLLGKALMEVRERIRR  170  315054313  eukaryota>fungi>ascomycota
    HCAG_05480_Acap_154278399            6    SEPVYFWKP------ESENGYLGQWYT----SDFTWAR-NAADAHGDVEI---VKYDNAEQFMMHRKGLLFA----------------PDDPITQEILARDS--PSPHPRDLRSLGRQIP-------------------NFDDAVW-----------KTHRYAIVVEGNYLKFTQ--------------------------NPQLKEELLAT------GDRELVEASPR--------DRIWGVGFGA-----------------------KNAGARRKHW-GLNLLGKALMEVRERIRK  178  154278399  eukaryota>fungi>ascomycota
    LACBIDRAFT_252516_Lbic_170107053     5    DDYVFFWKT------NEKYGWASQWYS----SPFTVKL-KL-EEEGEEEE---VTFASAEHWMMVQKALLF-----------------GDYGKAREILGVEG-VSSSDMAHVKALGRQVS-------------------GFDEAKW-----------VDARQDIVLQGNMHKFSQ--------------------------NGELLEKLMLT------GDKKMVEASPR--------DRIWGIGFGE-----------------------KNALNQRERW-GLNLLGIALEGTRRKLNK  176  170107053  eukaryota>fungi>basidiomycota
    PTRG_08392_Ptri_189204778            24   TKPVFFWKP---------NSYLSQWYW----SKFTVDG---------------DTYATAEMWMMVQKARLF-----------------NDEKTAKQMLAT------TKPHEHKALGRQVK-------------------GFEARVW-----------DQHKVQIVTQGNYHKFTIS-----------------------TDAENLRKMLLAM------GERELVEASPV--------DRIWGIGFAE----------------------REAERM-RHKW-GQNLLGKALVKVRGSLRA  180  189204778  eukaryota>fungi>ascomycota
    GCWU000342_00580_Ssat_229828516      1    MTVIGFHNP------DEKYGFLSNWYL----SHFTVHG---------------TEFSSVEQYMMYQKAACF-----------------YDEDIASQIMKT------DDVAEIKQLGRAVN-------------------GYDDHVW-----------NGIRQIVVYEGLMAKFSQ--------------------------NQELKEQLMDT------GGAILAECAVR--------DRIWGIGLSM----------------------TDPDRFDRSKWKGQNLLGYALMMVRDRL--  157  229828516  bacteria>firmicutes
    RflaF_010100008155_Rfla_268609453    14   MNVICFHNP------DEENGYLSNWYL----SDFTVDG---------------VKFTSMEQYMMYRKAMCF-----------------HDSDIAAQILET------SDVEQIKALGRLVR-------------------NYDDHHW-----------NGVRQIVIYEGLKAKFSQ--------------------------NPDLLKMLKDT------GDALIAECAVK--------DRIWGIGLSM----------------------TDPDRFDRTKWNGQNLLGYALMMVRNILTV  172  268609453  bacteria>firmicutes
    HOLDEFILI_02959_Hfil_223985602       2    MKIVCFHNP------DEENGYLSNWYP----SRFIVKN---------------RVFSSMEQFMMVRKAVCF-----------------HDDSAAAQILAT------EDVARIKELGRHVS-------------------NYDDHHW-----------NGIRQIVVYEGLLAKFSQ--------------------------NEDLKEQLKAT------GDAVLAECAVK--------DRIWGIGLSM----------------------SDPDRMNREKWQGQNLLGYALMMVREQL--  158  223985602  bacteria>firmicutes
    GCWU000341_01684_Osp._291459520      1    MNVIGFHNP------EEENGFLSNWYL----SAFRSDN---------------IDFSSLEQFMMYRKAVCF-----------------RDDESAARILST------DDTAKIKALGRLVS-------------------GYDGHIW-----------NGIRQLVVYEGLLAKFSQ--------------------------NESLKRDLLDT------GDALLAECAVK--------DCIWGIGLSM----------------------TDPKRFDPSQWRGQNLLGYTLMMTRSKLAA  159  291459520  bacteria>firmicutes
    _Bado_154487137                      2    TDIICFHNP------DEENGYLSNWYP----SRFVVVD---------------VEFSSMEQYMMYRKACCF-----------------NDAETAARILRT------SDVAEIKRLGRLVA-------------------GYDDHVW-----------NGVRQIEVYEGLLAKFSQ--------------------------NAELGAQLVAT------GNAILAECAVK--------DRIWGIGLSM----------------------HDPARLDPAQWRGQNLLGYALMLTRKKLNR  160  154487137  bacteria>actinobacteria
    ROSINTL182_08410_Rint_240146453      1    MDILCFHNP------DEENGYLSNWYM----SQFDVNG---------------IGFSSMEQYMMYKKAVCF-----------------RDDVIAEKILET------DEVGSIKELGRMVA-------------------GYNENYW-----------NGIRQIVVYEGLIAKFSQ--------------------------NDKLREGLLHT------KDQILAECAVK--------DRIWGIGLSM----------------------KDPDRMDLSKWRGQNLLGYTLMMIRDRL--  157  240146453  bacteria>firmicutes
    M23134_07250_Mmar_124009340          129  DEKFYFFSS--------SDSPFSTLYK----AKFIIQG---------------ITYNSVIQYIAHHKARLF-----------------LDRGIEKGILKS------DSQKEIYQLSLQVK-------------------NYDKVTW----------HNMYLGQHISFAYQQQFLQ--------------------------NEYLKDVLFST------EGKTIVLSDKN--------DEKWGIGLSQ----------------------LNSKALQRNTWLGKNFLGEILTRLRIELMG  286  124009340  bacteria
    PSPA7_5219_Paer_152985284            16   FKYLYFWGHRPAADDQVGKSCFSQWYE----ASFKLGG---------------VRYASAEHYMMAAKARLF-----------------DDRKLLERILAA------RSPGEAKALGREVA-------------------GFDEALW-----------SAERMGIVIEGNLGKFGQ--------------------------NASLKKYLLGT------ADRVLVEASPV--------DAIWGIGLAA----------------------TDPQATEPAAWRGLNLLGFALMEVRRRLAQ  180  152985284  bacteria>proteobacteria>gammaproteobacteria
    MDS_1227_Pmen_330502141              20   FDYLYFWGHSRAAGAPVGKSCLSQWYP----SAFTLDG---------------IHYATAEHFMMAGKARLF-----------------DDAEALERILAA------RAPNEVKAIGRQIR-------------------GFDEARW-----------RESRQAIVFEGNLGKFSQ--------------------------DPELARYLLDT------APRVLVEASPV--------DPVWGIGLAE----------------------GDSNVRTPATWRGLNLLGFALMQVRECLLN  184  330502141  bacteria>proteobacteria>gammaproteobacteria
    _Kora_238022350                      20   LKYVYFWGHTPKQKGIADEAVFSQWYP----APFELDG---------------ERYATAEHYMMAEKARLF-----------------GADDIRCQILQA------GSPAQAKALGRQII-------------------GFQDDIW-----------NAHRFDIVCRANHAKFSQ--------------------------HPDLKTFLLQT------GERILVEASPV--------DSIWGHRLGA---------------------RRPPRRKPVAMARLEPARLRADESARPIAGS  188  238022350  bacteria>proteobacteria>betaproteobacteria
    BBR47_45420_Bbre_226314127           19   VKYLFFWGHTQKDSGTTDKSCFSQWYP----AAFVEDG---------------ITYLTAEHYMMAKKAELF-----------------GDLAIRDEILRK------NHPKQAKDLGRKVH-------------------SFDEAVW-----------NANKTAIVRQANLLKFSQ--------------------------HADLKAYLLDT------GDRIIVEASPY--------DRIWGIGMAQ----------------------DHPHAEQPEKWRGENLLGFALMAVREQLRS  183  226314127  bacteria>firmicutes
    ABSDF2913_Abau_169634335             21   FKYLYFWGHIPKKANLIDKSCFSQWFP----AQFNVEG---------------IEYFTAEHYMMAQKAKLF-----------------NDKEIFAQILQV------KHPNEAKQLGRKVR-------------------NYDEQIW-----------REKRFDIVVQANFAKFSQ--------------------------HPELKKFLLAT------KDRILVEASPV--------DKIWGVGMAQ----------------------DHPHIQDPSLWQGLNLLGFALIHVRELLLT  185  169634335  bacteria>proteobacteria>gammaproteobacteria
    HMPREF0012_02967_Acal_262281016      20   FKYLYFWGHTPKQVDLIDKSSFSQWYP----VQFKDEG---------------IEYLTAEHYMMAQKAKLF-----------------NDEGIFAQILQV------KHPNEAKQLGRKVR-------------------NYDEKIW-----------QEKRFDIVVQANFVKFSQ--------------------------HPELKNFLLAT------KDHILVEASPV--------DKIWGIGMAQ----------------------DHLHTQDPSQWQGLNLLGFALMHVRDQLLA  184  262281016  bacteria>proteobacteria>gammaproteobacteria
    LMHCC_1724_Lmon_217965001            18   LKYIFFWGHQPAEDGKISKSCFSQWWI----CSFKVDG---------------VEYNCAEQFMMAEKAKLF-----------------NDMEMREKILAA------KHPKQAKDFGRLIS-------------------GFQEDIW-----------LKNRFNIVMRANQAKFSQ--------------------------NEELKKFLMQT------KNRILVEASPV--------DKIWGIGMAT----------------------DNKNVENPLYWKGLNLLGFALMVVRDELEN  182  217965001  bacteria>firmicutes
    PROPEN_00827_Ppen_226326967          16   IKYIYFWGHQ-SKGNDITKSCFSQWYP----APFILDD---------------VRYASAEHYMMAEKAKLF-----------------NDIDVRKRIITA------SNPGSAKALGREVK-------------------GFDQDIW-----------EQHRMDIVIRANIAKFSQ--------------------------NKELGNFLIST------GNRVLVEASPV--------DKIWGVGLSE----------------------QDNEINNPLLWKGLNLLGFALMKVRSILIE  179  226326967  bacteria>proteobacteria>gammaproteobacteria
    EHI_017590_Ehis_67472915             30   HQYTYFWKP--SIEEEVNKSCLGNWYP----SEFDYDG---------------IHYYFCEQFLMGCKAKLF-----------------GDDQIFKLILDS------RNPYEMKKLGKKVK-------------------GFNQEVW-----------DEYKAAVMFEGGLAKFTQ--------------------------NPQLRRFLMET------GDDILVEASKF--------DAVWGIKMEE----------------------SDERANDPHQWCGENILGFTLMSIRDYLLV  192  67472915   eukaryota>amoebozoa>entamoebidae
    CCC13826_2022_Ccon_157165319         106  DKFLLFWGHQKSA--NLSASCLSQWFN----SIFWQDE---------------TKYICAEQYMMAKKALCF-----------------GDKEALKQILSA------KDPAQMKGLGRQVR-------------------GFDAKVW-----------DEVKFGVVLNASYLKFSQ--------------------------NAPLRDFLLQT------GSKILVEASPV--------DKIWGIGLGA----------------------SDENAQNPMKWRGQNLLGFALMRARDEIAK  268  157165319  bacteria>proteobacteria>epsilonproteobacteria
    ANACOL_01151_Acol_167769817          19   CRFLFFWGHTPPADGHVNESCLSQWWM----CRFSAGG---------------VEYNCAEQYMMAEKARIF-----------------GDNEMLEKIMAS------KFPKEMKAYGRAVR-------------------NFDQAVW-----------DSRCYDRVLTGNLAKFGQ--------------------------NADLWEFLAGT------KGHILVEASPR--------DRIWGIGMGK----------------------QNPNAPNPTLWRGKNLLGFALTEAR-ELLQ  182  167769817  bacteria>firmicutes
    GYMC10_6272_Psp._261410041           18   FKYVFFWGHTPPKDGSVDKSCFSQWWM----CPFTVEG---------------TEYSCAEQFMMAEKARLF-----------------GDNEMLESILTA------KHPKEMKAYGRAVR-------------------NFDKDTW-----------DKECYGIVKRASLAKFSQ--------------------------NPELGDYLKST------KNRILVEASPR--------DRIWGIGMGQ----------------------SNPDAENPVKWRGRNLLGFALTEARDELLQ  182  261410041  bacteria>firmicutes
    HMPREF1977_0666_Coch_315224011       151  LKFLFFWKPNAD---AIDESCFSQWQL----SPFNVNA---------------NEYSCTEQYMMAEKARLF-----------------DDEEVEKEIMNT------TDPKLIKALGRKVR-------------------NFDPAVW-----------DKVKYSIVLNGNYYKFTQ--------------------------NQAMMDFLLST------GDKILVEASPL--------DTIWGIGLGK----------------------DNEKAFNIASWRGKNLLGFALMEVRDELRK  312  315224011  bacteria
    HMPREF9071_1307_Csp._326335654       113  LKFVFFWKPNCK---VVDESCFSQWQP----SSFCIDG---------------DEYSCTEQYMMAEKARLF-----------------GDKEVEEEIMNT------SDPKLMKALGRKVR-------------------NFDPQVW-----------DKAKYSIVLNGNYYKFTQ--------------------------NKEMMDFLLST------GDKILVEASPM--------DTIWGIGLSK----------------------DNEKSQNIAAWRGKNLLGFALMEVRDEIRK  274  326335654  bacteria
    Cbei_3546_Cbei_150018370             104  LEYIYFWGHHPKKDGGITKSCFSQWWK----SRFNIGH---------------TEYLFMEQYMMAEKARFF-----------------GDKEIEEKIMNS------YDPKEIKIFGRKVR-------------------GFDEEIW-----------NRAKYSIVINGNYNKFMQ--------------------------NERLKTFLLST------GDKILVEASPY--------DNVWGIQMSE----------------------EDVNIKNPELWRGENLLGFALMEVRNEIKR  268  150018370  bacteria>firmicutes
    _Fpra_160945914                      125  RELCLFWGHQPAKDGQLTKSCLSQWWT----EDFWFVA---------------NTYLCMEQYMMAGKAELF-----------------GDQEIREQILKC------SDPKQIKALGRKVR-------------------GFDQKVW-----------DKFKYAIVLNGNWCKFSQ--------------------------NRDLREFLLST------GDSVLVEASPY--------DNIWGIRLSA----------------------NSPEAQDPMKWRGQNLLGFALMEIRDELRR  289  160945914  bacteria>firmicutes
    LMHCC_1997_Lmon_217965272            94   YNFNQMKNENQPELYLFENCYFSHCWM----EEFSVST---------------QKYCCMEQFMIEQKAELF-----------------NDTTTKQKVLET------NSLEQIQALDKEVQ-------------------SFDQDIW-----------DKFKYAIALYGNWNKFNQ--------------------------KRILRDYLLST------GYSILVETNPS----------------------------------------GSPNMPNPLKRHGQNLLGLALMELRDELRR  248  217965272  bacteria>firmicutes
    BHWA1_00589_Bhyo_225619532           82   IDFLFFYGHT-NDKKEVTKSSLSQWYI----KDFRDND---------------LVFNCMEKYMMYNKALLF-----------------DDKDIANEILNN------NQPKAIKELGRKVK-------------------NFNDEIW-----------DKMKYKIVFTGNYYKFSQ--------------------------NTDLRNFLIST------KNKVLVEASPY--------DKVWGIKMKY----------------------DDENIENPFYWKGENLLGFALMEVRDEIKR  245  225619532  bacteria>spirochaetes
    Bmur_0365_Bmur_296125416             85   IDFLFFYGHS-NDKKEINKSSLSQWYI----KDFREND---------------LTFNCMEKYMMYNKALLF-----------------DDKNIADEILNT------NQPKAIKELGRKVK-------------------NFNDNIW-----------NNMKYKIVFIGNYYKFSQ--------------------------NTDLRNFLLST------KNKVLAEASPY--------DKVWGIKMKY----------------------DDENIENPFCWKGENLLGFALMQVRDEIKR  248  296125416  bacteria>spirochaetes
    CPR_0151_Cper_110802054              18   LEFLFFWGHTKNKNGKITKACFSQWYL----SDFTVNG---------------VLYNCAEKYMMAEKARLF-----------------KDYETLEEILSA------ENQKEIKDLGRKIK-------------------NFNEELW-----------NREKYEIVKRGNLAKFSQ--------------------------NENLKEFLLNT------GDKIIVEASPY--------DSIWGIGMGA----------------------KDENIEDPTAWKGENLLGFALMEVRDLLNK  182  110802054  bacteria>firmicutes
    FSDG_00336_Fsp._237744336            18   LKFLFFWGHTENG-AETTKACFSQWYS----CKFVVDE---------------IIYHTAEQYMMAQKTLLF-----------------NDNEIFHKIMSS------KSPKEYKELGRKIK-------------------NFSDSKW-----------NENKYQIVLKGNIAKFSQ--------------------------NEKLKVFLLNT------DTKILVEASPY--------DKIWGIGLSA----------------------DQENIKNPLTWNGENLLGFALMEVRDLLNK  181  237744336  bacteria>fusobacteria
    AceceDRAFT_0731_Acel_303238852       110  IKYLFFWGHQPSVDGSITKTCFSQWWK----SDFTIDI---------------EDYCCMEQYMMAEKARLF-----------------EDKEILEEIMKS------KHPKQIKELGRKVR-------------------NFDEEVW-----------KKKRYSIILNGNYAKFLQ--------------------------NEELRQFLIQT------QNRVLVEASPY--------DKIWGIGMSA----------------------DDEHIENPLEWQGLNLLGFALMEVRDELIR  274  303238852  bacteria>firmicutes
    Fjoh_0750_Fjoh_146298513             12   SKFLFFWGHQPSKDGTITKNCFSQWWL----SSFKVNE---------------VTYKTAEHWMMAKKAELF-----------------NDQEILEKIIQC------NSPAEAKKLGRKVK-------------------NYDDKIW-----------LENRFEIVKEGNYHKFSQ--------------------------NSDLKTFLLNT------NDRVIVEASPV--------DPIWGIGMAG----------------------DHKDALNPEKWKGLNLLGFALMEVRDELR-  175  146298513  bacteria
    KAOT1_16128_Kalg_163754439           29   LKFLFFWGHQPSKDGSITKSCFSQWWE----DAFTVNN---------------EIYKTAEHWMMAEKARIF-----------------NNSEIRKEILMA------SHPHDAKKLGRKVK-------------------NFDPIIW-----------DEHKFNVVVEGNYHKFSQ--------------------------HEDLKQFLLNT------KNRILVEASPR--------DRIWGIGMSE----------------------KNEKATNPNLWRGQNLLGFALMEVRDHLKK  193  163754439  bacteria
    Cpin_0074_Cpin_256419128             18   LNFTFFWGHK-GEPGNVTKSCFSQWWP----SAFTDGT---------------HTYATAEHWMMAGKARLF-----------------KDPAMEQEILQT------SDPATAKKLGRKVA-------------------NFDTALW-----------DVEKFSLVVQGNLLKFSQ--------------------------YPKMKEFLLST------GDSIIVEASPL--------DRIWGIGMGA----------------------NHEHAANPLLWKGQNLLGYALMEVRDQLKQ  181  256419128  bacteria
    HMPREF0204_10236_Cgle_300774513      18   IKFLFFWGHT--TKDTITKSCFSQWFP----GKFEENG---------------TIYKTAEHYMMAGKARLF-----------------NDPETEEKILKA------NTSNQAKALGRKVK-------------------NFDPKQW-----------DEHKFEIVTRGNLLKFSQ--------------------------NQKFKDFLLST------GDKVLVEASPY--------DRIWGIGMLD----------------------TDSRAENPLLWNGENLLGFALMEVRDELRG  180  300774513  bacteria
    EcSMS35_3361_Ecol_170684265          21   VKYLWFWGHQPAANHEITASCFSQWWQ---GSPFTYDG---------------ITYATAEHWMMAGKARLF-----------------NDSKTLARILAA------ATPAEAKKLGRQVT-------------------NFDEQCW-----------QACCFDLVCEGNYHKFSQ--------------------------HSALKTFLLNT------QPRILVEASPV--------DKIWGIGLAK----------------------DHPHAGVPSHWKGKNLLGFALMVVRDRLA-  185  170684265  bacteria>proteobacteria>gammaproteobacteria
    CIT292_10857_Cyou_283836396          21   FDYLFFWGHRPSSSGAITASCFSQWWP----SPFEVDG---------------ITYASAEHWMMAEKARLF-----------------GDESTLLRILSA------KSPAEAKAFGRQVS-------------------GFNQQVW-----------EENCFESVCKGNVHKFSQ--------------------------HPELGEFLIST------RTLVLVEASPV--------DRVWGIGLAQ----------------------DDERAGDPLRWNGSNLLGFALMVVRDRIAN  185  283836396  bacteria>proteobacteria>gammaproteobacteria
    Slin_1821_Slin_284036735             18   IKYLFFWGHQKSKSGDLTASCFSQWWT----SPFIIDK---------------VKYNTAEHWMMAQKALLF-----------------GDKEVYDKIIVA------KSPAEAKSLGRQVR-------------------NFDEATW-----------SAKRSGIVVQGSLQKFTQ--------------------------HPDLKEFLLNT------KERVLAEASPV--------DKIWGIGLAA----------------------DSDKAENPKRWNGLNLLGFALMEVRDILRK  182  284036735  bacteria
    Ndas_4523_Ndas_297563442             23   AEYLCFWGHQPPASGGVSASCLSQWWP----ADFTVEG---------------VGYRTAEHYMMAAKARLF-----------------GDAEAEERILAA------GHPRDAKVIGRQVR-------------------GFDEREW-----------EAARFGIVVEGGLGKFGQ--------------------------NPELREFLLGT------GGRVLVEASPR--------DRVWGIGLGA----------------------ENDDARVPERWRGLNLLGFALMETRARLAA  187  297563442  bacteria>actinobacteria
    AMED_1633_Amed_300783556             23   PEYLLFYGHTPSKSGRVTASCLSQWWV----DPFEADG---------------VEYPTAEHYMMAGKAALF-----------------GDHEKAELIRTT------PDPKAAKVLGREVA-------------------GFDAAIW-----------ERHRFDIVVDGNLAKFRA--------------------------HRDLRRFLLGT------GDAVLVEASKK--------DLVWGTGLAR----------------------EEKNATKPDYWRGLNLLGFALMEVRDQLRA  187  300783556  bacteria>actinobacteria
    Caci_2927_Caci_256392113             28   PKWRLFFGHRARIPGVVDEACLSQWWP----AEFRIGS---------------ITYFTAEHWMMVSKAQLF-----------------GDSDAWARVLST------RDPAVAKRAGRNAC-------------------DFDETTW-----------AAVRFGLVVAGNYAKFAQ--------------------------NSDLRAFLAGT------AGEVLVEASPY--------DRVWGVGLAA----------------------SHRDVRDPAAWPGLNLLGFALMRVREELMA  192  256392113  bacteria>actinobacteria
    Plim_2199_Plim_296122446             17   IEFLYFWGHTPPENGEVNHACLSQWYP----SPFTIDG---------------VVYPTAEHWMMASKARLF-----------------GDFATLAEIRAT------ISPKEAKAAGRKVR-------------------DFDEARW-----------EAHRFRFVVDGNWAKFTQ--------------------------NHTLRQYLLGT------GTKVLIEASPT--------DHIWGIGLSE----------------------QEARNSSPEHWPGLNLLGFALMEVREQISE  181  296122446  bacteria>planctomycetes
    Kfla_1718_Kfla_284029681             20   YKYVFFWGDTPSADGQADASCLSQWYR----APFTVGE---------------VRYPTAEHWMMAAKARLF-----------------GDRDAERDVLAA------GHPQQAKAIGRTVR-------------------GFDTEVW-----------QQHRFDLVVEGNVRKFEQ--------------------------NPVLRDYLLGT------GERVLVEASPV--------DRIWGIGLAA----------------------DDERAEHPDQWRGLNLLGFALMQVRDQLTT  184  284029681  bacteria>actinobacteria
    SSGG_05341_Sros_291448123            25   VKYLPFWGHRPRPDGRIGASCLSQWWP----SPFTVDG---------------VTYASAEHWMMAGKARLF-----------------DDPEAEAAAVTA------KSPAAAKKAGRLVR-------------------GFDEDVW-----------IGERFALVVAGSVHKFGQ--------------------------DPELAGYLLGT------GDRVLVEASPR--------DRIWGIGLAA----------------------DDERAERPQEWRGLNLLGFALMEARERLRA  189  291448123  bacteria>actinobacteria
    SGM_1884_Sgri_329936685              21   VKYLYFWGHQERPGGRLGASCLSQWWP----SPFIVDG---------------VEYATAEHWMMAGKARLF-----------------GDADAERLALAA------PHPAQAKKAGRQVR-------------------GFDEAVW-----------RRERFRIVVEGSVHKFGA--------------------------DEELREFLLGT------GERVLVEASPL--------DRVWGIGLAA----------------------DDEAAGDPERWRGDNELGFALMVARERLRE  185  329936685  bacteria>actinobacteria
    SSRG_01621_Sgri_302558106            33   VRYLHFWGHRPGPDGRVGASCLSQWWP----SPFTVDG---------------VEYATAEHWMMAAKARLF-----------------ADPEGERRVLAA------EHPAQAKKAGRLVR-------------------GFDEAIW-----------RRERFGVVVEGSVHKFAA--------------------------HDDLRAFLLGT------GDRVLVEASPV--------DQVWGIGLAA----------------------HDEGAADPERWRGPNLLGFALMEARARLRA  197  302558106  bacteria>actinobacteria
    KSE_25370_Kset_311895942             113  PKYLCFWGHRPQRDGQIGPGALSQWWP----SPFTVDG---------------VRYDTAEHWMMAGKARLF-----------------GNEEIVPRILGA------RTPAEAKNLGRLVT-------------------GFDEDRW-----------VEHRFELVVTGSTAKFGQ--------------------------DERLRTYLLRT------GERVLVEASPL--------DRIWGIGLAA----------------------DDQRANSPAQWQGSNLLGFALMEARARLAG  277  311895942  bacteria>actinobacteria
    _Ctes_221067792                      23   PKYLCFWGHQAERNGSVGKGCLSQWFS----APFTVEG---------------DRFATAEHFMMAGKARLF-----------------GDEEARAQVLAA------PSPASAKQIGRSVR-------------------NFDEARW-----------KAECFDIVVSANVAKFTQ--------------------------NPAMGEFLLRT------GERVLVEASPR--------DRIWGIGLGA----------------------THPDAEQPRKWHGQNLLGFALMAARTQLRA  187  221067792  bacteria>proteobacteria>betaproteobacteria
    PFL_5821_Pflu_70733106               86   PDCLMFWGHQPTRDGRISQSCFSQWFD----AGLELDG---------------IQYPSAEHFMMAGKALLF-----------------GDQETHGRILKA------VTPADVKQLGREVR-------------------GFDDARW-----------TEARLDIVVQGNLAKFSQ--------------------------HQALGEYLLST------GDQVLVEASPV--------DRIWGIGLAA----------------------EDARASRPEQWRGLNLLGYALMEVRDRLRI  250  70733106   bacteria>proteobacteria>gammaproteobacteria
    Daci_5761_Daci_160901192             23   PRFLPFWGHQPAADGSIGKTCMSQWFE----AGFEVEG---------------QHYPTAEHFMMAGKARLF-----------------GDEAAHAAIVRC------RTPGEAKKLGRGIQ-------------------GFDEAAW-----------VAARMDIVVRANEAKFSQ--------------------------NPALARYLLNT------GDRVLVEASPV--------DAIWGIGLAA----------------------DDVRATDPARWQGLNLLGFALMQVRARLRS  187  160901192  bacteria>proteobacteria>betaproteobacteria
    Amir_3505_Amir_256377585             7    MGHLFFWGHTPHRDGELGRECLSQWWE----RPFELDG---------------RVHPTAEHAMMTGKALLF-----------------GDERTAGRVAEA------RTPGEAKSLGRQVR-------------------GFDEDTW-----------ARERLELVARLNEAKFGQ--------------------------HDDLRAYLLGT------GGRVLVEASPV--------DRIWGIGLAA----------------------DDPRATDPDQWRGLNLLGEALMLARARLAA  171  256377585  bacteria>actinobacteria
    Caci_5873_Caci_256395008             3    VKYLFFWGHTPNRPGTVGAECLSQWYP----APFEVDG---------------LRFATAEHSMMWGKAQLF-----------------GDEQAAARIVAA------GHPKEAKDLGRTIR-------------------KFDEDTW-----------VAERVAIVTAGNVEKFRQ--------------------------NPDLLAFLLTT------GERVLVEASPM--------DRIWGIGLAS----------------------DDERAQDPARWRGLNLLGEALMAARKTLRG  167  256395008  bacteria>actinobacteria
    Sros_2401_Sros_271963927             26   LRYLFFWGHRPPRGGGVGAGCLSQWWE----VAFTVDG---------------HLFRSAEHYMMAHKAWLF-----------------GDGETAVRILAA------GHPGEAKKLGREVR-------------------GFDESVW-----------NEHRYEIVVGANIAKFGQ--------------------------HPELGDFLLGT------RGRVLVEASPV--------DRIWGIGLTA----------------------DDERAASPATWQGLNLLGFALMDARDALDT  190  271963927  bacteria>actinobacteria
    FRAAL2340_Faln_111221771             24   LRFRYFWGQRQAVADGTGAGCLSLRWP----ARFAVDG---------------VDYPSAQHYVLARKAGLF-----------------GDQAAAEAVLAL------PAPISLAAVGRRIR-------------------GFDEAVW-----------DRHRYAVALAANSAKFAQ--------------------------NAILRTYLAGT------AGLVLADISPR--------DRVWGIGCDR----------------------DDDRAGRPSAWPGRNLLGFALMEVRDALLA  188  111221771  bacteria>actinobacteria
    FrEUN1fDRAFT_4219_Fsp._288920206     31   LAFRYFWGHRRPAGGGIGPGCLSQWWA----VEFTVEG---------------RRYASAEHFMMERKARLF-----------------GDDETAEEILAA------PDPGRAKALGRRVR-------------------GYDDARW-----------ERHRHGVVVAGNTAKFGQ--------------------------HDDLRGYLLST------GSDILVEASPL--------DAIWGIGLAA----------------------SDERAGRPARWPGLNLLGFALMDVRAALAN  195  288920206  bacteria>actinobacteria
    FraEuI1c_6936_Fsp._312200713         33   LSFRFFWGHRPPAGGGVGASCLSQWYP----SPFTAEG---------------QRYATAEHFMMAGKARLF-----------------GDDKTVDAILGA------PDPGRVKALGRRVA-------------------GFDEATW-----------ERHRYDIVVAGNLAKFGQ--------------------------HDRLRGFLLAT------GDDVLVEASPL--------DTVWGIGIAA----------------------GDPRAEHPIDWPGLNLLGFALMDVRAALRS  197  312200713  bacteria>actinobacteria
    VAB18032_22000_Vmar_330468357        21   VKFLFFWGHQPQRDGSVGAGCLSQWWS----APFTIDG---------------LRFATAEHYMMWRKATLF-----------------DDHATAARVLAA------AHPHAAKMLGRQVT-------------------GFDQHVW-----------EQHRYDIVLTGTVAKFDE--------------------------HPALRTYLIGT------GERVLVEASPL--------DRIWGIGLAA----------------------DHPHATDPARWRGLNLLGFALMQARDILTG  185  330468357  bacteria>actinobacteria
    Micau_3582_Maur_302868047            29   VKYLHFWGHRPRPDGSVGASCLSQWWP----AAFTVDG---------------REFATAEHWMMWHKATLF-----------------GDHAIAERVLAA------GHPHRAKALGRQVR-------------------DFDEATW-----------TARRYEIVVAGSVAKFGR--------------------------HEPLRRFLLGT------GDRVLVEASPT--------DRIWGIGLTA----------------------DDPRAADPATWRGDNLLGFALMEARATLAG  193  302868047  bacteria>actinobacteria
    MCAG_03098_Msp._238062132            50   VKYLFFWGHRPQPDGSIGPGCLSQWWP----APFVVNE---------------VRYATAEHYMMVGKARLF-----------------GDEATAARMLTV------PSPGAVKALGRQVQ-------------------GFDQTVW-----------DAHRFDLVVAGNVAKFGQ--------------------------HPELRKYLART------GNRILAEASPV--------DRIWGIGLAA----------------------TDPRTCNPAQWRGLNLLGFALMHARAQLAT  214  238062132  bacteria>actinobacteria
    NBCG_01909_Nbac_326330475            37   PRYVHFWGHTPKGPG-VGMHVLSQWWP----KVFADAD--------------GRSFASAEHYMMWRKAVLF-----------------GDDRTAARILDA------ASPGAAKALGREVS-------------------GFEDEVW-----------LEHRWRIVVEGSTLKFGS--------------------------DPALRDYLLAT------RGRVLVEASPR--------DRIWGIGLGK----------------------SSPYAEEPARWNGLNLLGFALMEARNRL--  199  326330475  bacteria>actinobacteria
    EFP_gp169_BPphiEF24C_158079465       2    SKYILFWGHTPSKRNKLGKECLSQWYP----SQFTAPI---------EGLGEDIIFPTAEHYMMVRKAMLF-----------------NDVDTAKRILKT------ESPKDAKRLGRQVK-------------------NFEEDLW-----------VKHRKSIVLDGNTYKFTQ--------------------------NDSLRNFMLSIP-----KGTKFAEASPF--------DKVWGIGLRE----------------------SDPRSRDMSKWEGLNLLGEVLTEVRENLN-  172  158079465  dsdna viruses, no rna stage>caudovirales
    SS1G_05618_Sscl_156053544            46   LFELGFSR---------HTPFTSNPLC--------------------------KRTSTIFTYFQAVKAWVV-----------------KDRSKFMQIAHT------RSGLEAKKLGNAIK-------------------DLPVARW-----------DQISRHVMADALYFKFNH--------------------------NADIRNELIST------GSKVLIEARD---------DRVWASGIKT---------------------VKATAKTPISEWQGQNKLGEELMRLRHFFR-  193  156053544  eukaryota>fungi>ascomycota
    GSTUM_00003347001_Tmel_296414614     4    NPPIYFREDDLRY----YPFCLSHTCTF--TSSPTGPG-------NTAPPGVCCYFTSLTQYLQYRKALFF-----------------YDHRAAEDILTT------SDVSLIMSISRRIN-------------------GLQVEVW-----------NGMRNTLVREGLMLKFGQ--------------------------NEELRRLLLDT------GDRELVYASG---------TRDWGVGFAP----------------------TDAGKS-RDSW-GLNLLGQALMDVRRRLRE  171  296414614  eukaryota>fungi>ascomycota
    F44E2.8_Cele_32565136                54   DNVVYFNG---------PTHYLSALYP----CTVVVDG---------------NEYNSVEHYYQACKLYVL-----------------TGEQSAAQLKAS------ETPIEVKKATKNILKEAK-------------IPAKKISAW----------KDKDSIAVLKHVIYHKFNQ--------------------------NDELKVKLLDT------GDKILIQTYIG--------DTYFAAGANAKYTSTWVDRHVNQSLKYPENVVVDNVQYLPLVANGKNVLGWILMQVRDELRM  238  32565136   eukaryota>metazoa>nematoda
    consensus/100%                       -    ....................................................................................................................................................................h.........................................................h......................................................................b.....
    consensus/95%                        -    .....h...............hsph........h.....................h.s.-.hhb..+...h.........................h..........ps......s.............................W..................h......bh.p.............................h...L..o..........lhp............s..au.........................................s.hs..h...R..h..
    consensus/90%                        -    .....F...............hoph........h.h...................a.s.E.hhb..K...h.........................l..........ps......up............................W..............p..hh..s...Ka.p..........................p..h...Lh.T..........lhc.s..........D.hWu.......................................G.N.LGb.L..hR..l..
    consensus/85%                        -    .....F.............s.hSpa........h.hps.................a.ssEphhbh.K...F..................s......lb.........ps..h..hu+.........................p..W...........p..p..lh..s.b.KF.p..........................p..h...Lh.T.......s..llE.s..........D.hWG.s.....................................G.NbLGbhL..hR..l..
    consensus/80%                        -    ...l.Fa............s.hSpa........h.hps.................a.ssEpahbh.K...F..................s......lb.s.......ps..h..hG+p........................p..W...........p..+..lh..u.b.KF.p..........................p..h.pbLl.T.......s..llE.ss.........D.hWG.u.....................................GbNbLGbhLhplRp.l..
    consensus/75%                        -    ...lbFa............uhhSpa.......sh.hps.................asosEpahbh.K...F..................s.....pIb.s.......sP.ph..hGRp.p......................c..W...........p..+.plh.pu.b.KF.Q..........................p.plbpbLLsT......ss..llEsos.........D.hWG.G.s..................................pGbNbLGbhLMplRppL..
    consensus/70%                        -    .p.lbFa..........s.uhhSpa.......sh.hcu.................asosEpahbu.K...F..................c.p..ppIb.s.......sP.phb.hGRp.p......................c..W...........pp.+.plhbpu.b.KFpQ..........................p.plbphLLsT......ss..LlEsos.........D.hWGhG.s..................................pGbNbLGbhLMplRppL..

    #====== global.consesus
    consensus/100%                       -    ....................................................................................................................................................................h.........................................................h............................................................................
    consensus/95%                        -    .....h...............hs.h........h.......................s.c.hhb..+...h..........................................................................h.................hh.......h...................................l.............h.c............p.............................................s.h.............
    consensus/90%                        -    .....h...............ho.h........h.......................s.E.hhb..K...h.........................h..........ps......sp............................a.................hh.......h.p..........................p..h...l.............h.-............c...s.........................................s.h.b.....p..h..
    consensus/85%                        -    ...h.h...............hS.h........h..ps.................h.s.E.hhb..K...F.........................hb.........ps..h...s+............................a..............p..hh.......h.p..........................p..h...Lh............h.-.p..........c..hs.........................................s.h.bhhb..+..l..
    consensus/80%                        -    ...l.h...............hS.a........h.hps.................h.ssEphhbs.K...F..................s......lb.........ps..h...s+............................a..............p..hh....b.bh.p..........................p..h.p.Lh.s..........lh-.s..........-..hs.......................................u.s.hsbhhhp.R..l..
    consensus/75%                        -    ...l.h.............s.hSpa........h.hps.................a.osEphhbu.K...F..................s.....plb.s.......ss.phb..uR............................W...........p..+..lh..s.b.+h.p..........................p.pl.pbLl.T..........lh-.s..........D.hau.s.....................................GbNbLGbhlhphR..l..
    consensus/70%                        -    .p.lbF.............s.hSpa.......sh.hpu.................a.osEphhbu.K...F..................s.....plb.s.......ss.phc.huRp.p......................b..W...........pp.+..lh..s.b.KFpp..........................p.plbpbLl.T.......s..ll-.ss.........D.hWGhs.....................................GbNbLGbhLhphRpbL..

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Multiple Sequence Alignment of the BC4486 ART family

    ALIGN           ---EEEEE----HHHHH-H----------------------HHHH-------------------EEEE--------------EEEEE-------------------EEEEEE--HHHH-----------EEE-----------------------HHH-HHHHHHHHHH-----------------------HHHHHHHHHHH-----HHHHHHHHH---------HHHHHHHHHH------------EEE------
    HMM             -HHHHHHHHH--HHH-------H--HHHHHHH-----HHHHHH----------------------HHHHHHHHHH------H--EEE---EE--------------------E-----E-------EEEEE---------HH-------------------------EEE--------E---HH-------EHH---EEEEEE------EEEEEEE-----------------EEE--E----H----EEEEEE---
    FREQ            --EEEEE-----HHHHH---------HHHH----------HHHHHHHH----------------EEEE------H-------HHHHH-------------------EEEEEE--HHHH----------EEE---------HHH-----------H-HH-HHHHHHHHHH-----------------------HHHHHHHHHH-------EEEEEEE-----------HHHHHHHHH-----------EEEE------
    PSSM            ---EEEE----HHHHHH-H-----HHHHHH---------HHHHHHHH-----------------EEEEE---------------HHHHH-----------------EEEEEE-----------------EEE----------------------HHHH-HHH-----------------------------------EEEE----------EEEEEE---------HHHHHHHHHH-------E---EEEE------
    FINAL           -EEEEEE----HHHHHH-H------HHHHHH--------HHHHHHHHH----------------EEEE---------------HHHHH------------------EEEEEE----------------EEEE-------HHHHH-----------HHH-HHHHHHHHHH-------------------------HHHEEEEE-------EEEEEEE-----------HHHHHHHHH-----------EEEEE-----
    225620246       KLIYHLTAINNFESIIRN--GLCPRNKIKP----NIDVADNEILNGRNKY-N---------LLDYVPFHFFINTP-------FDGAVKKKY-----------KTTDFIYICLEREIAKM-------NEFKIIPCHPLSNRLINYENI---LFDYDKGF-DLIEWDKIDSDN-------------RNYVDQDIKNACMAECLYKGVISCRIFSSISVKD-----VESFKKIDKILLK----F-G------FISDKNKY
    307823107       KLLYHLTSIKNIGPILAD--GLKPRAELKN----FDDVADSEIIVNRRHL-S---------LENFVPFHWFARNP-------FDGRVQADR-----------PNDLFVLITVERTLAVS-------RNWKVIPYHPLSAGNIEL-------MDYSKGF-AAIDWDTMNRR---------------DYHDPLCKSICMAECLSPITVSPDDFFNIFVYC-----DDSVSYVRRFDRQ--I-------KITKNERMFLP
    104779561       RFLYHLTSVANVSSIFQR--GLLPRTVLDEE--EFADIADAEIILGRRQQ-G---------LEQYVPFHWFAKNP-------FDGRVYQDR-----------PDEEFVLIAVERSHAQT-------QNWSVIARHPLSGSRFEL-------LGYDEGF-EAIDWDLMDRR---------------DYHDQECKHVCMAECLAPGPVPVSQFAKIYTPS-----DEIFGYVRAQAVA--AGFRN---LWIDANRNMFP
    269140414       QFLYHLTDLNNLEDIFSE--GLKSRSLLRG----FSDVADPEIIASRSAL-R---------LEEYVPFHFFARNP-------FDGRVHRNN-----------PNKTFVLITVRRSHAQT-------NSWSVIPRHPLSGSTITL-------LDYEAGM-ATIDWETMNRR---------------EYGDDNCKCVCMAECLSPTSVPASDFNSIFVPD-----AETEATVNNLKRT--YGL-N---MYVNNSPHMFP
    299141966       RFLYHFTDKRNIPSIKRHG-GLFSWHYCET-----NNINIPRQGGDYDSR-ELD-KKYG--LQDYVRLSFCDDHP-------MKYRLQQ-------------SGSDMVVLRIKIDVALL-------KDTLFSDINAADRLHTH--------GGSLLDL-KRVNFDATKRH-------------FVSKNDEDFKP-HQAEVMVKTFVPLKYIVNI-------------------------------------------
    268609383       NGFYNIMPISNLASVLKY--GILSNELAERI--PHRSVAMSIIQDRRDQV---LIPNGLM-LHQYANLYIDARNP-------MLYKRKD----------------EDVIVLKVDCRILD------LPDVVVSDQNASSSYVRFY--------EPEEAM-NKLDFNMIFAR--------SWESDNQ-FEYWRKKSAKCAEVLVPGKIEPSYVIAAAVK---------NDADKEKIIA--LGF-D---KRIYVNGDLFF
    254410814       KYLYHMTAISNLRSILQH--GLLSHKEAHRLELVMMDISDPEVQRRRDDK--KDTIYSRL-LHDYVPLYFSPRNP-------MLYRRREI--------------QENIVILGIKPEVIF------KANTVFSDGNAASKGTIFY--------NDVAML-DSLCWNIINAL--------NW------SDFPEGKRIKCAEVLVYPKIDVKNIVSIFCYS-----GNQLSTIHETIRYF-RAIPLSLTISVQVKPELFF
    302864537       QELHFITPISNLESVLRH--GILSHNAARRL--PHLSVADEDVQSRRRQK---RVPGGMQ-LHDYANLYFDARNP-------MMYRIKGN--------------GTPLAVVCVNPSILD------LPGVVITDGNAASDGTRFA--------ASPGGI-AILDEGLVYAH--------SWTSSDR-WDYIERKRARCAEVLVPNCVDPSYIDKAKVI---------RQSHVISCHA--AGL-R---GEVF--ANVFF
    297618118       TELHYITHIENMKSIMRF--GLLSNRRASRT--RHNSVAMQVIQERRAGK---RVPGGLL-LHDYVNLYLCARNP-------MMYKLRGR--------------HKELCVLRIDVGVLN------IPGTIVTDRNASSDWACFY--------PSPVGL-KHVDLELVCAQ--------SWVHNDE-IETFKHKSIKCAEVLVPHHVPTSFFKGVYVSC----AESMSRLHCLAGDG--K-L-E---IEVY--PHMFF
    315652379       TGIYNIQAIDNIPSIIRR--GLLSNERAVSI--KHKSIAMDEVQARRDNI---IIPNGLK-LHQYANLYFDPRNP-------MLFKRKSQ--------------NEEICILKFDRVILD------FNGVVLSDRNASSSYAAFY--------EAKYGL-ENIDFKLVYAR--------YWTDDNY-FEQCRRKSIKCAEVLVPYGISYDYVVFAAVV---------NDAAADRLRL--NGF-D---KNIFIEPKIFF
    91215317        GGLFYITHLDNVASILKL--GILSHNLAHSNGFVSTDISNQQVNARRNRI---DPNLGGN-IHDYTPLYFNHKNP-------MLYTLCKN------------TDRNKLILLKVNPHILL------AENVSFSDGNASVRSTKFY--------NNIEEF-NNINWTLINSG--------SWNHYEF-NIKREQSRIMCSEVLAKEKIPSYYINEIFVYS-----EETLEQILPMFPN---HL-G---IKTSINKSLYF
    163847525       KRLYHITHIDNLASILQY--GILSHRQVESQNVSFTPIYNENIVHNRKER---LTPDQRS-LWDYANLYFQPRNP-------MLYKVLSEK-----------STREIVILGVKPQVLDT-------KGAFIALGNAAHSQTEIVD-----VATGRKVI-TGEFWPIIHSD--------WW------KPEDGTKRKIMAECLIPHVIVPEAIHSIFVAH-----PSVADTVRSIIAE----I-PC-PVEVVTEPHLFF
    161528666       QYLFYITHIDNIPSMLQN--GILSHDQIVKQKLEYTSIYDSDIVSSRREK----TANGKS-LWYFANLYFQPRNP-------MLYRVTMEK-----------SPDCIAVVAVDKKILTT-------PNTIITDGNAANGPTHFYP------NTEFKTI-ERQINRITSLQ--------WW------TDSNATKRQIMAECLVPERIPPEFIRAIYVSN-----HTLADEIRNSMSS------S---ISIIPEPSMFF
    156740099       KSLFYITHINNLESIFQH--GILSHARVEEMGIPYTPIYDAQIVSNRRER-S--TPDGKS-LWRFANLYFQPRNP-------MLYRVINKI-----------DKKEVAIIGVRPEVLSY-------PGCYISTGNAASSPSEILP-----VKEGIKAI-F-EMWKIIHNE--------WW------NPDDGSKRKIMAECLVPDFVSPDMIQTIYVVN-----HDVAKDVRSRISG----A-R---VPVVPEPSMFF
    295087467       RYLYHFTDRRNIPSIKRHG-GLLSWSYCEK-----HKIDIPNPGGGNLSR-N--LDEMRN-LQDYVRLSFTTEHP-------MMYVAMKDG-----------RISNPVILRIDPSVVYL-------QHTMYADMNATTTKRTPNI------GKSLEDF-KKIHFSTVKAH-------------KHFDLDENERPYFQAEVMVMTFIPKKYIINLDTF----------------------------------------
    307299774       KHLYYLSPVKNIPSILEH--GVMSKMAVETLEIPYDDYSDQTVQTIRERK-S---------LHEYVPLFFNTRNA-------MTFRYQKE--------------NRDFAILRLNSDLVT------HYDCLVSDRIAACSDAEIY-------TLSEPAL-KKINIEVVLST-------RNFY------DNWLLKKRLGAEILVKIDMIEPEWIECIILD------RTAEKIKGISIR----------QLRDSGYTYYF
    257093309       GHLWHFTDIRNLAPIRRAG-GLYSWAGLGA-----LGISDAYMLANDFSR-SCDARLG---RDRYVRLSFIPNS--------WFFQRVRWS-----------CPQAVWLRFSLKAVTL--------GEVDYSLGNAASGFVALRDDLPS--MGINWDM-VTPSPPHPCDKGPTRYPTLYPDQVGDPFLFRQISNAWNSEVLIKHYLPLD-FCTGVFDC----RSGEALNI---------------------------
    84392321        PFLVHFTNLKNLESIFNN--GLVPRSQLDA-----SDSEYESNDDSRLDG-----------HEDSVSTSVAFPNC-------QMFYKLRRN-----------SDDKFCLLALDPELLLN-------HSSAFCKYNAADAAISSQNIET---LKTAEAF-EGMFTELATQR---------SR--EDQKLEDYDPTDVQAEILVFDTIPKGYIGAVVFP---------DKETEKQFKG--IIG-G---CKSYVHNPNKG
    218779300       EEIVHYTTMNGLIGILAT--KMVKSRERVA---QESLLEYILQLNTPLRK-----DTG---WLDYVSLSISNMNS-------WLFHFSSKKWH---------TNSKFCILSFKPEILSH-------NGVFFATTNNMYPAVRRG--------EGETGF-EALFAPIVLGRY----NAPIIR--SP-TCHDSCPTCEQAEILYPGELSTDFLLRIYVEE---D--DDEDSVHGIFGG--VGH-AK--VPVEINPGKFR
    125718682       HRLCHFTHVSNLSNILKG--NIFSSRSIPR--DQWNDSDRVDGYIDYVCT-S---------VELPNSYCLKN----------MVRKTQTNI-------------EEWIIFKINPYIID--------DTSLFCPLNAAKECGKYVSEG----VEAYESI---FLNEG-RTRN-------------P-KWISSVPSNLQAEVLIKGIIPINQIKGVIFHE---N--FVDDDIFKLVNQ--AN------IEIRQSTDLFD
    281416943       TRLCHFTKLKMLTHILSSNEGILASA-CIRSDV-KTVIDADRYEGEPEYV-C---------CSIEYPNSWFLSE--------AQRRDTDQIF------------RDWVVLYINLRILNY-------RDAKFCPCNASKGCGRYI-------FSDLNKL-ITLYFSPTVVGR-----------LRTPNMLECCPTDDQAEILIKNSIPRDYITGIAVGN-----NDIAERVSAILKT--YSI-FG--MRIFIAPDVVS
    113473935       EYLCHFTPAPNLPNIIAH--GLLCRAHLST-----AGMPAYTSIDHRLDG-----------EDQAISVSISAINH-------RMFEAKRAAS----------GRTDWIVLFLCPSILWT-------HECRFYARNAARREMLDHRG----FLGGPWAF-NRMFSESSHPNGFTG--YSYRVDT---GIADALTTYSDAEIQVLEPISPEYVIGAWANN-----MPLAEIAQSCLNR--LSG-SE--RDVQVSSPHRV
    60461910        DHLVHFTNINNIDNIMRH--GLLNTQDLKE-----QNIPFIFTDEYKLDG------------RHGLSLSVQFPNY-------KMFYSKTNKS----------PQNDMVVLLLDPELINE-------KKCLYFYDNAATTELKNMSSSD---LMTDIAW-EKMFSDKVDGI---------LR--SELKIPNSFTTNPQAEVICLEPIEPKYIKNIICK---------SDDQFGRVSN--Y-------LDIVGKDEHYF
    260557664       KSIFHFTRVENLNNILTN--GIIPRNNLSN-----KTSIF--NDTVRADG-----------KLDYSSFSISFPNH-------LMFYRLRCAV----------PESKWAILVFKSDLLTT-------NNCLFYPVNAASSNVSRSPVDM---FRGGQAL-ERMFTYSAESR--------------ESVLRACDPTDVQAEVMIPGIVTMENLKGCILS---------EKDLVEFFSK--RFP-N---IKFVHCHSGRQ
    153817479       EYLWHFTKLENVSSIFQS--GIVPRATLEA-----NQSNVAYNDQHRLDG-----------FKTASCFSIGHPNY-------KMFYSLRQQD----------PSVEWVVFGVKAEVLWT-------KDCAFCTTNAANSSVTSVPIEQ---RKGVQAF-ESLFLPVAGKP---------SR--QELQLPDDCPTDPQAEVLVFDTILPSDIVGVIVP---------TKAKELELKP--LYP-A---HQVVYHRAHYS
    239627870       EHCVHFTNVLNLPSILSY--GLLSKADLEY-----NWIEYNHNDNLRLDE-----------FEESISVSITSPNY-------KTFYQWRCDN----------PSKSWVVLILDAIQILN-------LDCAFCYTNAANIRISSIPLAE---RKTYSAF-ESMFAEKQNQA---------TR--QEMKLYPNEPTDPQAEILVFNSIPVSAIQFALFN---------DYQIMKQYAP--LLD-N---ANIPYTRDLGY
    149186577       GHLVHFTQAENLASIMQN--GILSVSSLRR-----RGISFRQNDISRYDY-----------QINASSLSITHPNE-------KLFYKWRMED----------PSQDWVVLLIESSILRR-------RDLAFNIHNAADKRMSSRPLSA---RKGVDAF-EGMFAEIDGFA---------KR--AELGLRDQDTTDVQAEVLAFQKIEPRLILGAVFD---------SLGAMARYSN--ILG-N---RDISCVQPNTG
    71064898        QILCHFTPINNLESILNN--GLYPRDYIDE-----NLPDAIWTDDGRFEG-----------MKNGVCLSISFPNH-------QMFYRKRMQLK---------DIESWAVIVLDARVIKL------NHDCAFFQTNSAFGDYRNKSLSE---FMTSNAF-FSLFEEKVETRN-----GVVTR--QD-YLTDEFPTDVQAEVVVFDHIPPDSIEACYLQ---------SEKYLKYFEE--KFS-K---FTFIEDSNDNS
    294664142       KALFHFTREENLASILSR--GLLRRDQL-S-----SSEGAVFNDDLRLDR------------TSAICLSVGFPNY-------KMFYPLRINN----------PDTKWVVIAVMPSVLWM-------LPCAFCTTNAASNAVTASTLAQ---RMGLAPF-QNMYGDCSGKI----------R--SSLGIPNDYPTDPQAEVLVLNDIPPAYLMGLATH---------TREGKDRILS--RHA-G---THVIHAPTLFS
    237813317       RNIVHFTRLSNLASIIAN--GIVPRSTLVA-----KNLLFEYNDAYRHDG-----------YLNASCFTIGWPNY-------KMFYPIRCSN----------PDVNWAVIECSPAILWE-------KPCIFSAQNAASNAARLVPLEQ---RTGLSGI-TGIFAEIPGKP---------TR--AEMGVHESFPTNPQAEVLVCDIVEPRYFVRVHIE---------DWASRNKLAA--EY------HPLPFVTGWEG
    189425638       SHLVHFTRLENLEGIMRQ--GIRTRYDLDN-----SGTGYIYNDDLRLDG-----------YPNAASISVSYPNY-------KMFYSYRCAD----------HNVPWVVLRLRPDILWE-------KNCAFCWENAASTNVTCIPIEN---RRGREAF-LDLFVNKSGYP---------TR--ETTLIPRSYPTHPQAEVLVFGTIEPAYITRVDLP---------TRFNPNSVFS--SIN-RH--CEFWYDDDLFW
    206563731       KYLVHFTRLSNLASILAH--GLVCRNRLDG-----RNVIGAVNDQYRLDR------------TDAVCVSIGFPNY-------RMFYRYRQEN----------RGENWVVVGIDPSALWK-------LRCAFCITNAAAGRVSAIPLDQ---RTGLPAF-QAMYGDFDDKV----------R--ANLHLADQFPTNPQAEVLMLDGVPAAYFLGVAVQ---------NDMMKAQVEA--LHP-G---LHVVRHEEFYS
    260590817       EFLIHFTPTINLYSILEQ--GKLMSRKTLE---NLDIEQFDILDYAQFTD-NV---RCD--DKGFINLSISGPNT-------FLFSKFQERTKD---D----MTIDWCILKIDPKYIYE-------KETKFSVTNAASNVAKAIGV-----TGDLDKF-KMLFANSINIP---------YG--IRGKINSKYPTNVQAEVLVKKDIPVESIIEVCFNSIE------SFASAKAALS--EFD-T---SNFVVDMEIFS
    258545511       KYLCHFTPQNNLEHIKNY--GLLLRNEMPC--------GATITDSTRADN-----------VRSAICMTISKPNR-------WMLEQ-KQREG-----------HHLALLLISPDVLFM-------RKCLFYPHNAATASLRRRPIED---FMGIDAF-KEIFAEEVEYKK-SGKESQIIR--RSSHLSAAETTSDQAEVQCLEQISPQHIMRIITY-----NIPLDYQDVQILAG-----------KLFLNPQRYR
    229129771       TRLCHFTNSRSFIHIIQNDLGVVANNFLGD---EEEIGIMSKNDNLRLDG-----------KEDYISCSIEYPNT-------WYLDKVKLRDP---------NFRDWVVLFIDPLVMLE-------ENTLFCHRNAAAGEGKYL-------KSGNEGL-RGMFAQTVDGK-------FKIN--RAYNMLSCCPTDGQAEVMVYKNIPKESIKGVCVSSMEQVKIEMLKISHLNLLE--GEL-N---FDWIISPELFS
    30022567        TRLCHFTNSRSFIHIIQNDLGVVANNFLGD---EEEIGIMSKNDNLRLDG-----------KEDYISCSIEYPNT-------WYLDKVKLRDP---------NFRDWVVLFIDPLVMLE-------ENTLFCHRNAAAGEGKYL-------KSGNEGL-RGMFAQTVDGK-------FKIN--RAYNMLSCCPTDGQAEVMVYKNIPKESIKGVCVSSMEQVKIEMLKISHLNLLE--GEL-N---FDWIISPELFS
    224477788       TRLCHFTKSKNLPFILGEGVDSDNGILANN-----FISDTSFLNKTDENR-FD-------NHEDFICTSIQYPNC-------YYFSTVVKKNQ--TE-----IFNEWTILGISPEIID--------DSTKFCPVNAATKGGRMI-------GNGAEAF-EEVFSERVEGKR-------IF--VRNQNYPDNVPTNVQAEVLIYNKIPKENITSLIFPT---EAIAEKECLRLELCG--VNV-SQ--YDIIVSSDLFE
    237800583       ESILHFTSNSGALGVFAS--RALKSRQRLN---ADQQLKHIFQPNARFRD-KD------VAWLDYANLSISQINT-------AFFKTCSGSWH--KE-----KDFFWCILDFSPSIMLH-------DDVWFTTTNNIYTGVKRA--------CGVEGL-EAVFQPT-THQY----QANYVR--RPADHPSNLPTCYQAEILYPQELSTDYLQRIYVRC---D--NDTDELAGQMAA--TRH-PQ--VEVVVRPELFE
    325690156       TRLCHFTKSSNLPYILGGTDEEANGIISNK-AIRDSECKFLKLNDIHRYD----------NRPELICLSVEYPN--------FFFFEKSIEKE--KES----LLNDWVVLLISPSIIN--------EETYFCPVNAAKNRGAHIG------KGSQKFM-ELFNTEVLGLNR-------------SVSMLPNIPTNNQAEVLSPDMIPKDKIIGLVFSS---KKQARDEVLRLKLCQ--IEL-RN--LKIYYSHEWFK
    148821249       WIVWHFTHADNLPGIITAG-RLLADSAVT---PTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSP-------MLYVVCKGHSG--YSG----GAGPLVHLGVALGDIID-----ADLTWCASDGNAAASYTKFS--------RQVDTLGTFVDFDLLCQR--------QW---HNTDDDPNRQSRRAAEILVYGHVLFELVSYVCCYN-----T-ETMTRVRTLLD--PVG-GV--RKYVIKPGMYY
    15607201        WIVWHFTHADNLPGIITAG-RLLADSAVT---PTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSP-------MLYVVCKGHSG--YSG----GAGPLVHLGVALGDIID-----ADLTWCASDGNAAASYTKFS--------RQVDTLGTFVDFDLLCQR--------QW---HNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYN-----T-ETMTRVRTLLD--PVG-GV--RKYVIKPGMYY
    90419305        ALIFRIVHRDNVEWILDN--GLHCKKAHVS-DPNYVAIGNLELIDRRTNH-PVPCHPNG-TLGDYVPFYFTPFSP-------MMLNIKTGYGG-IRKR----ANEEIVVLVSSLHKLNE-----AGLPIVFTDRHAYLQAARFY--------TDMQRL-NEIDWAILRAK--------DFK--RNAEDPGKF-ERYQAEALVHRSLPCAGLLGIACY-----NEAVMASVKRQTER--RGL-N---MRVIAQRKYYF
    307823108       ALIWRIVHRDNLSWILDN--GLHCANSKTL-SPNYINIGNSDLIDKRRHR-VVPIAPSG-TLADYVPFYFTPFSV-------MMLNIHSGRGG-VPRR----RNEEIVILVSNLHHVHS-----IGLPFLFTNAHAYPNWTNYY--------SNLAQL-YNIDWDILQRR--------DFK--RDPDDLRKM-ERYQAEALIFKHLPINGILGIVCY-----TEQLKHDIEQQVQD--RNL-M---LEVYARTKWYF
    228911570       TFIYHMTHYRNLSKILSSN-GLVCVSNIMNNGQTYCNIANNDIQSRRASY-SVPVEPFG-TLHKYVPFYFAPKSP-------MLYSIYKGNVI-QYNE----GQEPLIYFVSSAQKIKQ-----NGVPFCFTDGHGIMHFTEYY--------NDLTEL-HNIDWDIMKSK--------YWHDT---IEDNDRKRRRMAEFLVYQYVPLDCIIGIAVYS-----QKYKEETEKILTE--HNV-S---LPVKLKPNWYY
    309811906       PGIVHFTRVEHLGTIVQQ--GLLSDHAVGS--ALQHEIGNRNIKAQRTRR-VVPIPPGG-VVADYVPFYFAARSP-------MMYSIAMGNVP-GYAE----GTARIVYLVSDVGRVLT-----DGMRVVISDRNAALHVAAFRP-----PTVELFAG-DFIDWDLMRAR--------YWGQYDDGSTRADGRERRMAECLVHQKVSWGCITHVVAKS-----EAVAREARLLLGD--RLP-P---GGVVVRPEWYF
    326943719       TFIYHMTHYRNLSKILSSN-GLVCVSSIMNNGQTYCNIANNDIQNRRAYY-SVPVEPFG-TLHKYVPFYFAPKSP-------MLYSIYKGNVT-QYNE----GQGPLIYFVSSAQKIKQ-----NGVPFCFTDGHGIMHFTEYY--------NDLKEL-HNIDWDIMKSKY-----------WHDTIEDNDRKRRRMAEFLVYQYVPLDCIIGIAVYS-----QKYKEETEKILTE--HNV-S---LTVKLKPNWYY
    292493384       GLIFRITHRDNILWILDH--GLHCPNGTVF-DHNFVPIGNPELIDRRHHR-EVPIPPGG-VLGDYVPFYFTPYSP-------MMYNIKTGYGG-VKKR----RNDEIVVLVSSLHQVAK-----EQRKFVFTDRHAYLRAANFY--------NNINDL-NLVDFKLLRSR--------DFS--RDVEDPEKI-ERYQAEALVHQSLPVQALLGIVCY-----TKAVADEVQSVLRV--RKI-T---MRTLVKPSWYF
    257455836       GLIWRIVHIANLPWIFAN--GLHSGNSPIQ-SPNWQHIGNPELIQKRANH-PVPVGRQG-YLNDYVPFYFTPFSP-------MLLNIKSGRG--VMQR----PMQDIVILVSSIDTVES-----QHLDYVFTNSHAYYQWTNFF--------TDRKDL-DKIDWALLQRR--------DFS--RDPNDLAKF-ERYQAEFLIYQHCPISAIIGICCY-----NDNVKQSIQQLINM--SGI-T---LDVHSRPNWYL
    215486216       ALIWRIVHRDNIPWILDN--GLHCGNSLVQ-AENWINIGNPELIGKRAGH-PVPVGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKRR----PNEEIVILVSNLRNVAA-----HDVPFVFTDSHAYYNWTNYY--------TSLNSL-DQIDWPILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPISLLDGIICY-----SEEVRLQLEQWLFQ--RNL-T---MSVHTRSGWYF
    256023435       ALIWRIVHRDNIPWILDN--GLHCGNSLVQ-AENWINIGNPELIGKRAGH-PVPVGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKRR----PNEEIVILVSNLRNVAA-----HDVPFVFTDSHAYYNWTNYY--------TSLNSL-DQIDWPILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPISLLDGIICY-----SEEVRLQLEQWLFQ--RNL-T---MSVHTRAGWYF
    304560215       ALIWRIVHRDNIPWILDN--GLHCGNSQVQ-AVNWINIGNPELIGKRAGH-PVPVGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-ITQR----PNEEIVILVSSLRSVAA-----QNAPFVFTDSHAYYNWANYY--------TRLEDL-NQIDWSILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
    238921299       ALIWRIVHRDNIPWILDH--GLHCGNSPVQ-AANWINIGNPELIGKRAGH-PVPVGMGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-ITQR----PNEEIVILVSNLRNVAA-----QNIPFVFTDSHAYYNWVNYY--------TRLDDL-NQIDWSILQAR--------DFR--RDPDDPAKF-ERYQAEALIWKHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
    269140415       ALIWRIVHRDNIPWILDH--GLHCGNSPVQ-AANWINIGNPELIGKRAGH-PVPVGMGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-ITQR----PNEEIVILVSNLRNVAA-----QNIPFVFTDSHAYYNWVNYY--------TRLDDL-NQIDWSILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
    253687260       ALIWRIVHRDNIPWILDN--GLHCGNSPVQ-AGNWINIGNPELIGKRAGH-PVPAGAGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKQR----PNEEIVILVSSLRTVAA-----QNVPFVFTDSHAYYNWANYY--------TDLNNL-NQIDWPILQAR--------DFR--RDPDDPGKF-ERYQAEALIWRHCPITLLSGMVCY-----NDSVKLQLEQWLSQ--RNL-T---MPVHARAGWYF
    104779562       ALIWRVVHRDNLPWLLDN--GLCAVSRGNL-SSGYVGIGNPDLISKRSRR-AVPIHPGG-TLADYVPFYFTPFSV-------MMKNIHSGRG--VQQR----RNEEIVILVSSLYHVRS-----LGLPFVFTDAHAYPDWAGYY--------SDLEHL-DKIDWQILQSR--------DFK--RDPDDPRKM-ERYQAEALIHGHVPVAGLLGIVCY-----NEALQRRVDQEVRQ--RQL-D---LPVHARPGWYF
    206579710       ALIWRIVHRDNIPWILDN--GLHCGNSPVQ-AANWINIGNPELIDKRAGH-PVPAGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKQR----PNEEIVILVSSLRHVAT-----QNVPFVFTDSHAYYNLANYY--------TDLNNL-HRIDWPILQAR--------DFR--RDQDDLAKF-ERYQAEALIWQHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
    288457846       ALIWRIVHYSNLPWILDN--GLYCGNSKIK-SPNWFNIGNPELIQKRADH-SVPLPPSG-MLNDYIPFYFTPFSP-------MLRNISTGWGG-IPQL----PNEKIIILVSSLHHIAD-----LGLPFLFTDSHAYSPCANYY--------SNLSDL-NQIDWPILQHR--------DFK--RDPDDPAKF-ERYQAEALIYQHLPINGLYGIICY-----TELLKQRIEQEICA--RNL-N---LRVYARPEWYF
    146305602       ALIWRIVHRDNLVWILDN--GLHCASANVQ-APNYVVIGNVDLISRRRER-TVPVAPGG-TLSDYVPFYFTPFSP-------MMYNIHTGRGE-VQQR----HNEEICILVSSLRRVHE-----LGLGFAFTDRHAYTPLARYF--------NELDLL-EQLDWPLLQAR--------NFS--RNPDDPEQI-ERYQAEALVHRYLPIEGLLGVVCF-----TQAVKDRLDAQAQA--KGL-K---LDIRVMPQWYF
    209527878       TYIYHITHLKNLPSILRSE-GLLANNHLKSQPINYVDIAHETIQNKRAQI-NIPCSRGG-TLHDYVPWYFAPRSP-------MLYAISRGNVQ--GYE----QGQSPVIHLVATAEDIA----AASLPFAFTDGHAIVRYSEFY--------DNLDSL-NAIDWEIMNAG--------YWA--DTLEDGDRK-RRRQAEFLVYEFFPWTLVREIGVI-----DAGRKAEVEEILQN--FTI-S---TPVKVFREWYY
    209527890       TYIYHITHLKNLPSILRSE-GLLANNHLKSQPINYVDIAHETIQNKRAQI-NIPCSRGG-TLHDYVPWYFAPRSP-------MLYAISRGNVQ--GYE----QGQSPVIHLVATAEDIA----AASLPFAFTDGHAIVRYSEFY--------DNLDSL-NAIDWEIMNAG--------YWA--DTLEDGDRK-RRRQAEFLVYEFFPWTLVREIRVI-----DAGRKAEVEEILQN--FTI-S---TPVKVFREWYY
    300868768       TFIYHITHINNLESIVKAG-GLLACNAMYEANAEYTNIAYDGIQDRRART-SVPCSVGG-VLHDYVPFYFAPRSP-------MLCAINNKGKVK-GYS----EGQTPIIYLVSEVEKIA----DSNLHFAFTDGHAVMTFTDFF--------DNLEYLDEAIDWEVMESR--------YWF--DTDEDNDRK-RKRQAEFLVYKFFPWQLVTEIGVK-----NYQIKTEVDKILEKN-TTH-Q---PPVKTRTAWYY
    119483244       TPIYHITHIDNLVSIISSG-GLIACSQLRQQQVRYTDIAHQNIQDRRANK-PVPCSVGG-LLHDYVPFYFGPRSP-------MLYAIYRRNVQ--GYQ----GSQSSIIHLVTEIETIA----NSDLDFAFTDGHAIMDYSDFY--------DDLWQLGEVIDWGLMEER--------YWS--DTEEDRNRK-WRRQAEFLVHRFYPWRFITAIGVI-----NDSIKTKVQSILQK--KQH-Q---PLVRVCSNWYY
    307154521       PSIYHITHLNNLASILRAG-GLIANSRLRQQQINYTDIAHEQIQDRRARK-RLPCGAGG-TLHDYVPFYFAPRSP-------MLYAIHTGNVR--GYQ----DGQDSIIHLVTDIEAPFF---EEENAFVFTDGHAIMDYSDFY--------DDLNALDFVIDWELMKSK--------YWF--DTEDYPDRK-WRRQAEFLVYERCPWDLITEIGVI-----NSTIQLRVQNILKN--FSD-L---TPVRVYPNWYY
    218295754       TLIYHITHLNNLQGILQRG-GLLPYSQRPPTQ-QNVAYGHIQAHRAQVVV-PVGPR--G-KLHDYVPFYFCPRSP-------MLYAIHTQQT---DYQ----GDQRPILHLVSSAQKVA----EARIPFVFTDRHAAVQYVCFF--------HKLEHL-KALDWQAIQAS--------YWA--------NVR-EKKQAEFLVKDFFPWELVEEIGVI-----DKTIQAQVESILAQFPDLH-H---PPVRVRRSWYY
    310818319       PLIFHITHVDNLPNILREG-GLWCDAQRIARGLSSTNIGHLHIKQRRLLR-PVTTTAGG-TLGDYVPFNFCSRSV-------MLYAVHCGHQ---DYK----GGQESIVHMVSSVSRATA----LGRAWAFTDRHAELAHALHF--------DDLGKL-GEVPWQVMPLQ--------YWS--------EVK-EERQAEFLVREFFPWEAVTEVAAM-----TPAASARVQQALRG--AAH-H---PPVTTQAGWYY
    30249340        PKLYHIVHVDRLSSILKDG-FLWCDVHMAQHIPVGTTIGMNNIKQRRLQNC-LNSYPDL-HVGDCVPFYFCPRSV-------MLYLIYRQNT-ELDYK----GGQGPIIHLEADLNAVTTWAKTQSARWVFTLTNAGSFYFEDR--------NDLTCL-KEVNWTAVHAL--------NWK--------EHK-EGKQAEFLIEQCFPWNLVERIGVQ-----SEVIYNHVVNALPV--NGH-R---PKVEIKPEWYY
    38505777        PKIYHIVHVDRLPSIIADG-CLWCDAAISQRNPAGTTIGMNKIKQRRLKELTLTSHPSL-YVGQCVPFYFCPRSI-------MLFLIHKKNT-ELTYQ----GGQEPIIHLEGDLIQAVNWADQNNLRWAFTLSNAGSSYFEDR--------NSLAQL-HEIDWAAVQAT--------NWQ--------TCK-EGKQAEFLVESTFPWHLVERIGVK-----SRVIYDQVIKALPT--GGH-H---PQVEVRPDWYY
    120608868       PKLYHICHVDRLPSIIASG-GLLSDAAVVQVAAPGTVIGMNHIKQRRMTELQLTSHPGL-YVGQCVPFYFCPRSV-------MLYLIHRQNA-DLAYK----GGQGPIVHLEADLHTTVAWANGQGLRWAFTLSNAGARYFEDR--------ADLGRL-GEVDWDAVAAR--------NWS--------AQK-EGKQAEFLLERGFPWQLIERIGVL-----SQPIATQVAHALPV--GGH-R---PPVQLMPAWYY
    217979677       PKIYHIIHSDRLASIIADG-FLWPDAAMAQRQGVGTTIGMSNIKARRLNELTLSCHPHL-RVGHCTPFYFCSRSV-------MLYLIYRRNE-ELTYK----GGKSRSSIWKLISTRRLL-GRNRTIGAGRLLCRMPVRITLRT-------GRTLRSL-A-INWDAVQAR--------QWS--GNAVSRSVK-EGKQAEFLIERAFPWRLVERIGVF-----SQGYVQPVSQAMQG--AAH-R---PEIEIRRDWYY
    189425258       PKIYHIVHVDRLTSIIASN-GLLCDAEIVRSKPPGTTIGMGTIKQRRLNELFLSSHFGL-NVGDCVPFYFCPRSV-------MLYLIWRANDPELTYR----GGQAPIVHLEADLHQTVAWAESQNLRWAFTLSNAGAYYFEDR--------SNLDRL-GDIDWQAVEAT--------NWQ--------KCK-EGKQAEFLIEQRFPWELVTRIGVM-----TTQTHAQASAAIAA--STH-K---PRVELMQNWYY
    154253368       PKIYHIVHVQNLASIVTDG-HLWSDATMVNRPPGGTVIGMGGIKLRRLRL-PVTCHQGT-HVGDFVPFYFCSRSI-------MLYVLHCANHAELTYR----GGQQPIVHLEADLYRSVRWAEENGSRWAFSLSNAGAAYTQFR--------SKREQL-SEVNWEAVRAT--------DFR--PA----DVK-EGKQAEFLVERSFPWHLVERVGVH-----SQAVVDQVSTAMRG--VRH-R---PQIEIRKDWYF
    146294612       PKIYHIVHVDRLAPILASN-ALLCDAEIIAQQAAGTTIGMNTIKQRRLNELTLDSYPDL-YVGQCVPFYFCPRSI-------MLYVIHRADSAELVYR----GGQGPIIHLQADLHATVQWAQQQGRRWAFTLSNAGSYYFEDR--------NDLARL-NELDWQAIGAR--------QWQ--------GCK-EGKQAEFLMEHSFPWHLVEEIVVQ-----SPIIHQQVVNTLQR--VGH-R---PPVRINPNWYY
    251788569       PKIYHILHIDRLHSIIAE--GLLSDEQISVRHGAGTMIGMSSIKQRRLHELTLTNHPNL-YVGQCVPFYFCPRSV-------MLYLIYRANHPELAYR----GGQEPILHLEADLYTTIAWAEQHRQRWAFTLSNAGSLYFEDR--------CQQSQL-GELNWEAIQSN--------QWS--GGN---GTK-EAKQAEFLIERCFPWHLIERIGVH-----SPLIYQQVANMIPL--DGH-R---PPVEVKREWYY
    153872688       PKIYHIVHIDRLASIIAAG-ELWCDAQIVAQNPGGTTIGMTSIKQRRLYELSLNSHPNL-HVGDCVPFYFCPRSI-------MLYLIYQANHPKLAYY----GGQEPIVHLQADLHASVAWAHKQKRCWAFTLSNAGSYYFEDR--------CDLAQL-NELDWAAIQSN--------QWQ--------HCK-EGKQAEFLMEASFPWNLIERIGVF-----SQPIYQQTMNILQT--GVY-R---PPITISREWYY
    257095819       PKLYHIAHVDRLPSIVTDA-CLWCDSEVSRRGPAGTMIGISSIKQRRLSELTLSSHPGL-HVGDCVPFYFCARSV-------MLYLIHQANHPELAYR----GGQSPIIHFEADLGAVVDWADRQGRRWAFTLSNAGSRFFEDR--------CDLAQL-GEIDWNAVQAR--------DWR--------QCK-EGKQAEFLLEHSLPWHLVERIGVQ-----SRPIFQQVSNALPA--SGY-R---PAVDIVSDWYY
    284119730       PKIYHIMHIDRLASIVADD-YLWCDAKMATRTSSGTTIGMNGIKERRLTN-PLHSHSGL-RVGDCVPFYFCPRAV-------MLYVIYKANHPELDYR----GGQGPIVHLEADLRQTVVWAERQQRRWAFTTSNAGSRFFDDY--------ADLADL-DKIDWDAVHAT--------DWR--------QCQ-DGKQAEFLVQDSFPWAMVSRIAVN-----SKEIYAKVQLVLRE--ARH-R---PPVEVKPDWYY
    148654473       PKIYHITHVDNIRNIVSTG-GLLSDARILQQGGPTQMIGLSNIKRRRIEELEVRCHPGT-KVGEYVPFYFCPRSI-------MLYVIHRADHPELMYR----GGQDSIAHLEADLHQVVDWADNNGVRWAFSLSNAGARYTQFR--------SNLRYL-HELDWDAIAAT--------DFR--DS----DVK-EGKQAEFLVHGFFPFDLVERIGVH-----RANIWNKVRSVLAG--SGY-T---PRVEVRDDWYF
    126667035       PKVYHIVHVDRLASIIADQ-VLWSDAQVIARAPAGTTIGMSGIKQRRLNELTLTSHPDL-YVGACVPFYFCPRSI-------MLYLIYQGNHPDLGYK----GGQGPIIHLEADLNDSVAWAEANQQRWAFTLSNAGSCYFEDR--------SDLFRL-NEINWTAVGAR--------NWM--------SCK-DGKQAEFLLENCYPWHLVERVGVC-----SQAIYTQVANILAG--VPH-R---PDLQIKPDWYY
    254245305       PKIYHIVHVDRLASIIRSG-ALWCDARVIRDGADGTTIGMSSIKRRRLQELQLDSHADL-YVGQCVPFYFCPRSV-------MLYLIYRGNHSELTYR----GGQGPIVHLEADLRQSVAWANANRHRWAFTLSNAGSYYFEDR--------CDLRHL-GDINWDAVQTR--------QWQ--------SDR-EGKQAEFLMEDSFPWGLIERIGVS-----SAQAYQQVVNALPA--GGH-R---PTVEVKHDWYY
    261344446       PKIYHIVHVDRLSSIFASN-GLLCDAEVIFQNLSGTNIGISNIKKRRLTELQLSSHSNL-YVGQCVPFYFCPRSI-------MLYVIHRGTNTNLTYQ----GGQNSIIHLQADLYASVQWAKKHKNRWAFTLSNAGSYFFEDR--------CDLSQL-NQLVWQDIQAT--------QWQ--------NCK-ENKQAEFLMERYFPWHLVEQIVVH-----SQDIQQKVIQLLRM--EEH-R---PPVTIKSDWYY
    46309426        FYLIHETSFEALSKILQGS-FLLTSSKTQKLKVRGQGSSNRRLASDPRV-----------SLTDSEFFNKYDEVD-------GVYMRLQPKMHSIRYS------KSDCVLVLRMNLLKYC------KFVINSEENFGFYIAEEC-------VIGTSQFSGEPGFTTTSFE-------KLALLK-------DTTDYSSTEVLILQDVPVSFIKFIFLV-----RDTKADTIFKPLAR--YNI-KC--FNIL-------
    192290492       TAIFHITAIANLDSIAKQG-ALLSKNEAAARGLVAANIAYDHIQGRRAVR-TVPIAPGG-TLHDYVPFYFAPRSP-------MLFTINQGNVPDCIYR------QDDIVHLATTAQTVAD----TGQQIVFSDIHAALDYARFF--------SDLGSL-TEIDWRIFFEPPRLEGYCKFWQNRQIPIHHLRRLEIRQAEFLVHGELPIAAISEIGVK-----TAQAAAQVEQAVAG--SGW-T---PTVRVVPGWYF
    74317508        VRLFHITAIANLPAICAAG-ALLSKNQGATNGIAYQNIAHQGAQGARSIK-SVPNPPGG-LVHDFVPFYFAPRSP-------MLLAINGGRVAGCDWR------QADIAHFETTVEHVTA----AGEDFVFYDLNATLAWSTPY--------TGLANLD-KVAWDLICESPALDGYCKYWQSKLDHARYSDRMERRQAEFLVKGMVPLVRFTRIGAI-----DRGHADVVRAILDQ--AGV-K---LPVVVKPEWYF
    237654251       TRLFHITAIANLPAIFAAG-ALLSKNGGAAAGINYQNIAHAGAQGARAVR-AVPNPPGG-LVHDFVPFYFAPRSP-------MLFAINGGRVAGCQWR------QTDIVHFETTVQCLVA----RGRPFVFYDRNATLAFSTPY--------TDLAHLDTAVAWDLMTEAPQLDGYCKFWQNNPAVARYADRMERRQAEFLVRDNVPLDCMTRLGVI-----DAARQAQVLALLAQ--AGV-A---LTVDIMPAWYF
    317126949       RFLLHFTRAENLNSIFRYG-ILSVSKQKSL------SLEVSRNDPNRYDE-----------FLNATSVSIHLPNN--------ILLYKYKNKFNC-----------EWVVLGIKPDIIWE------KRCGFCNENAASSNVSKIPLNK---RMSVESL-NGLFNNISGKPSR----SKLNIDK------SLT-TSPQAEVLVFEDIEPSYIWGVAFE---------SNYAKNKYKE--NIP-SS--IKIEIVPELFR
    255010210       TCFYHFTDRRNLLSIKKQR-GLLSWHYCKT-----HGIVIPNQGGDADSE-NLDMRYG---LQDYVRLSFCDDHP---------MTWRLKQS------------GSNLVLLRIKIDVAWF------KETLFSDINAADQLHSHG--------GDLCHL-QKVNFAATKRH--------YVNRND-----ED-FKPHQAEVMVKTFIPLEYIINIDNPILI-------------------------------------
    328871094       TQLYHFTDKSNLDSIKQN--GLFSWDHIDQ------NGIQSVMGSNEDSR-RLDKRKG---LEDYVRLSFVQNHP-------MMHAAYKRDSI----K------QPIILVIDIMVVDLL--------DVKFSDVNATSNNVIIQ--------NDT----NHIQFSIFKKD--------YFKLST-----NE-KQYFQAEVLIRNNVPASYIKRSITPNMGRKST---------------------------------
    282881570       KYAFRIVHIDNIPYILEN--GIVNAAKSTKKDDSYISIGDESLIEVRRNQ-NIIHTESC--IGDYIPFYFGPRTP-------MLYTIQHGYNG---VK------KCDATNLVYLVLKISDIIKS-GFQGYFTDGHARNICSHTYE------IDKLNQL-NELVHYENVYR-------TYWSIR--EDNSGEYKRLKSAELLIENNIPTTMIAGYVVY-----DKAAHDKLVSFGID------N---EKIIINNNYYF
    310778852       FNLLHITEFDNIKSILETG-GLISLRKLEV-----ENVCPKFMTS-EASR-SLDRCKG---LDAYVRLAYTTWYD-------MIPTAVFYNNL----K------NPAVIIVNCELLNKK-------RDILFTTKNAVANDAIYY--------KQ-NEIGDHINWEKVFSE--------RNY----DTQSQEYKDARQSEVMVQDIVEKDYFVCIFVETGS-----DLKDLNG--YG--VEI-KE--DNIKSIINRFG
    262039223       MWIHHLTHIDNLESILER--GLISRNQLKQFNIKFNDTADKRIIGERND------------LNNYIPFHINYLQKKY-----SIPYNWKVLKNQ---S------SENMIFLNYNIDDFSN------NELDFYLYHPISKSQNNA--IK---INDLMGF-KEKLLKEEKKLQ--------NDMGYLDFSDNKTQQFLMSEVLIKDRIYLSEKWKIGVFS-----FAQKQIVEKKLEK--NNL-K---IEVFIDDKRYF
    88856595        QRVYHVTHISNLENILLTG-QLVAAAQIES---PILDVSSPLTREMRGTA----SLSTGETVDRYVPFSLVPESNTWRELRDGAGEPRWSDAAR-AAS------SSDFVFLVTTIRALGT-------DAVLADGDAAAGETIFA--------TDEGAM-TRMLGNLRA-----------------------DELTEDAEVLIHGSFAFDEVQLVGVAS-----DKARDRVKELLDA--ASF-V---TKVAVYPPWFI
    222529646       FGIYHYTDFTNLESIFKEG-FLYSRVDCIKKGLQFTDGADHNVLSIAPYD-----------VKNKVRFYFRPNTPTLFE-NEGIKLPAYIGK----AH------MPIPVCLLFDDELILL------DTTEFSNGNATSVKYTQI-------GCTYAFF-KSMEWDLIFHEG-----------YIEPFERNKIVNRRNSELLSTTPVSLKYLKKVIFRT-----KADFKRASNLF-G--MN------KKFCVDINYFS
    126652604       RYIYHFSDIQNIVSILKCG-YVASRNFAIENGLMKNENACLDVIDKTTHD-----------NKNLARFYFRPKTPTQYH-NEGIKSKFREYEND--AH------IPVPVFLVFDAVGMFS-----KNQSMFVERNLVYSPPIK---------KHISEL-EKFDFDKIYHS-----SSLYGYSS---YDKQEIIEKRHAEVVFKDFCSLDCLRSIVCRS-----SAEKDTLIHLLRF--EGV-DVSKYRIVTNGNELL
    328958126       RYCYHFSHIDNIISILNTG-KVYSRSKSKELKLMQNDNASQDVINQTNIL-----------VKDYVRLYFRPKTPTQYH-NEGLRNLRTTTTLN--AH------CPFPVFLLFDL------------KQVLTSENSFFCKHSLAHSSEYHLCNTPLEL-ANFPFSKIYHD--------RSFSGAQR---NEIISHRQAEIVVPNEMSLNTLKKIMVRSIA-----EKETLMYMLSA--DSK-KKYNELIQIDSKKIV
    262383473       PKAYHFTHMDNALKIIRSM-KLQSRNLA--TGC-FSNSAGTNVLRTSK-------------AHRFARFYFVPQSPTQFY-NECLGKDSSDIRYYQKALNLGLPKCPMPVFLIFDVEELLMAM---PDKCYYSNGNMQKDASRSF--------KVVDNP-NMIKAKEIYTD--------SFS----------TKNERQQEFLIDGELDFSYLTKVQIRCY---DEYQAATLRKELLG--TKW-E---NCIKVDRSLYT
    MARKUP          ..........!**???....*.....*...............................................!**...............................................................*....<--------------------.ARTT.loop.-------------------->....**!....................................................
    STRUCT          .....S1..........................................................S2.........................................S3...................S4...................................................................S5............S6..................................S7.......
    consensus/100%  ..h........h..h.......................................................................................................................................................................................Eh.....h...................................................
    consensus/95%   ..hh.h....ph..l......h...............................................h......................................h.....................h...ps.....................h.......................................uEhhh...h....h..............................................
    consensus/90%   ..lh+hs..ppl..Ih.....l.s......................p..................s...h............h........................hh.....................h...ps.....................h...h...............................p...AEhlh...h....h..h...........................................
    consensus/85%   ..lh+hsp.ppl..Ih.....l.s......................c..................s.h.h....s.......hbb......................hh.h...................hs..pu.....................h...h...............................p..pAEhLh...hs.p.l..h.h.................h..............h......h.
    consensus/80%   ..lh+hsp.psl..Ih....slhs.s...........hs.......R................pbssh.hs..ps.......hhb.h....................lh.h..s..............hhhs..pA.....p..........ps...h...h.h..h............b.............p..pAEhLl.p.hs.phl..h.h.................h..............h.....ba.
    consensus/75%   .blaHhsp.pNl..Ilp...ulhs.s.h.........hs......pR.p..............phssh.as.pps.......hhh.hpp................p.ll.h.ss..............hhas..pA.....p.b........ps...h.p.l.hp.h..........p.b..........p..p..pAEhLl.p.hs.phl..l.h.............h...h..............l.....ha.
    consensus/70%   .blaHhschsNlssIlp...GLhspsph.........ls..ph..pR.p............h.phsshhasspss.......Mhh.hpp.p.............pp.ll.l.ss...h..........hhFss.pAh....p.b........ssh..h.p.l.hphhp.........p.hp.........p.bp.bQAEhLlbp.hs.phl..l.h......p.....ph.p.l........p.....l.hp..hab

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Multiple Sequence Alignment of the KptA family

    PDB:1wfxA  -    -     HHHHHHHHHH--------------------EEHH--HH--HHHHHHH--------------HHHHHHHHHHHH----EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEEE--------------------------------------------------------------EEEEE---HHHH-HHHHHH-----------EEEEEHH------------------------HHHHHHHH-----EEEEEEEHHHHHH-H--------------EEEEE--EEEEE-----------------EEEEEEEE--
    DOMAINS    -    -     <---------------------------------------------------------------------------------------------Helix-Turn-Helix-------------------------------------------------------------------------------------------------------------------------------------------------------------------->......................................<---!**--------*---*-------R++h!**-----------Catalytic core-------**-----------------------------------------*------------------------------->
    118430933  314  40    SKTLAGILRHH--PGR-YGVR--LTRE-GWARVS--EV--VEGLRKA---------gWSWVEEWHIVGVALHDP-KGRYELRN------------------------------------------------------------------------------------------------------------------------------------------------------------------GEIRARYGHS--IP----------VNVEP------------------------------LPGEPP---PILYHGTTEEAL-PLIMERG--IMRGRRLKVHLTSSL------------------------EDAVSTGRRHGNLVAVLLVDVECLRR-R------------GLKVERMSKTVYTVD-----------WVPPECIAEVRRESL  208   Aeropyrum pernix K1                                      archaea>crenarchaeota
    154496777  381  5     SIYLCRLLRHA--PED-AGLD--MDIH-GWVSTQ--QL--IDNVNKAg---------RHHLTMPQLEQLVATDS-KGRYRFSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------KSRIKACQGHS--IPw---------VEPEL------------------------------TPAAPP---AYLYHGTTERAW-NAIQDSG-YISRMSRHAVHMQADEs-----------------------KAWQSACRWRQ-APVVLKIDAQAMAA-D------------GIPFGVSDNGVWCTE-----------QVDRKYVCTEQVDRK  179   Pseudoflavonifractor capillosus ATCC 29799               bacteria>firmicutes
    268610712  382  5     SKYLCLLLRHQ--PEK-AGLD--MDEH-GWVSIE--QL--INGVNCHs---------SYKLDRELLEQIAAEDN-KGRYRFDEK----------------------------------------------------------------------------------------------------------------------------------------------------------------HEKIKCCQGHS--IPw---------VEPEL------------------------------EYCEPP---EFLYHGTTAKAL-EAIEESG-AIKKMKRHAVHMQADIg-----------------------KAWQSAERWHK-TPVVLKIAASEMNK-D------------GYKFGVTENEVWCTE-----------EVPVKYICTEEVPVK  177   Ruminococcus flavefaciens FD-1                           bacteria>firmicutes
    116252353  384  11    SKYMSYVLRHA--PDA-AGLT--LDSG-GWVSFD--EL--EKALASK-----------YDVSRAEIIEIVENNP-KKRFTLA------------------------------------------------------------------------------------------------------------------------------------------------------------------HNRIRANQGHS--VD----------IDLAL------------------------------NQAEPP---AALFHGTSLTNW-QSIEREG--LKKMQRHHVHLSADVe-----------------------TAKIVAARRKG-EHIILRVDAARMFS-E------------GHSFFVSDNGVWLAE-----------SVPVQYLLAESVPVQ  177   Rhizobium leguminosarum bv. viciae 3841                  bacteria>proteobacteria>alphaproteobacteria
    124003655  387  1     SKRLSYVLRHR--PEE-IELI--MDEE-GWVEVD--LL--LDRFSNN----------YFPITLADLQKVVAQND-KKRFAFSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------EAYIRASQGHS--IQ----------IDLGY------------------------------EAIKPP---AQLYHGTATRFV-HSIREQG--LKKRNRHHVHLSADI------------------------DTATKVGGRHG-QPVILTVNALDMQQ-D------------GYKFFQSENGVWLTD-----------QVPVQYLEFPEENVQ  181   Microscilla marina ATCC 23134                            bacteria
    338211687  389  6     SKFLSLVLRHN--PAL-IGLD--LDAN-GWAPVK--EL--LAKMKAK----------GHGISMEELKHIVETNS-KKRFAFSEN----------------------------------------------------------------------------------------------------------------------------------------------------------------FEKIRANQGHS--VE----------VDLGY------------------------------EKQVPP---AVLFHGTAEKNF-DLILKDG--IKKMSRHHVHLSQDI------------------------TTARKVGMRHG-KPVVLSVDAKGMAD-G------------GFDFYLSNNGVWLID-----------FVPAEFIKVDDCFAE  176   Runella slithyformis DSM 19594                           bacteria
    312888255  390  2     SKFLSLVLRHQ--PEL-IGIE--MDEQ-GWVKVT--DL--LEKANAH----------GKALNMDVLKYVVDTNA-KKRFAFDES----------------------------------------------------------------------------------------------------------------------------------------------------------------QTYIRASQGHS--VE----------VELGY------------------------------LPQIPP---EILYHGTGSQSV-DAILKTG--LEKRARQHVHLSHDV------------------------ETATKVGSRHG-KPVILKVLAADMHQ-Q------------GYAFYLSENKVWITD-----------GVPAQFLEVFGVPAQ  180   Mucilaginibacter paludis DSM 18603                       bacteria
    110638931  391  14    SKFLSLVLRHQ--PEL-IGLQ--LNEQ-GWAHIE--TL--LEKSAAY----------GVSFDKQTLKYLVATNS-KKRFAFSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------AEYVRASQGHS--VD----------IELGY------------------------------KNQKPP---EILYHGTAEKFM-QSILETG--LEKCRRQHVHLSSTI------------------------ETAIHVGQRHG-KPVVFTVLAQQMYA-N------------DFSFYLSDNGVWLTD-----------HVPVIYLTINPVPVI  191   Cytophaga hutchinsonii ATCC 33406                        bacteria
    146298511  395  1     SKFLSLVLRHS--PEK-IGLK--LDEN-GWADVN--EL--IEKCTKK----------GNRLDAELLDYVVENND-KKRFAYNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRASQGHS--IS----------VELNL------------------------------AETEPL---EYLYHGTVGKFM-ESIQKEG--LKKMSRQHVHLSKDK------------------------ETAVKVGSRRG-VPQILTVRSGAMYR-D------------GFKFYLSENNVWLTD-----------EVPPKYIEFKSVPPK  180   Flavobacterium johnsoniae UW101                          bacteria
    256419129  396  1     SKFMSLVLRHQ--PET-IGIT--LDEN-GWTDVE--EL--LTRMSQH----------KHPITLAQLQEVVETND-KKRFAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRASQGHS--VD----------VSLGL------------------------------DPVTPP---EYLYHGTVARFL-DSIKKEG--LQKMSRQHLHLSKDR------------------------ETAVNVGSRRG-APYILTIRTGQMHR-D------------GFLFYLSDNGVWLTD-----------HVPPAYIEIDHVPPA  180   Chitinophaga pinensis DSM 2588                           bacteria
    163754445  398  6     SKFLSYVLRHN--PDK-LGIT--FDSN-GWTSVA--IL--LEKINVE----------PYSLSMEELEYVVATNN-KKRFAFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTMIRASQGHS--VN----------IDLAL------------------------------QPKEPP---SYLYHGTVEKFI-TSIQEKG--LIKGTRQHVHLSADK------------------------ETAINVGSRRG-KPIILTIRSGEMYA-Q------------HHTFYQSENGVWLTE-----------EVPTEFIEFEEVPTE  179   Kordia algicida OT-1                                     bacteria
    300774500  399  1     SKFLSLILRHQ--PES-IGLT--LDEN-GWADVE--EL--REKSAKR----------RIHFTPEELDEVVETNN-KKRFAFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTMIRASQGHS--VN----------IDLAL------------------------------EALQPP---DFLYHGTAETNI-ASILEKG--IEKRTRQHVHLSADK------------------------ETAAKVGMRHG-KPVILTIRTGTMYQ-D------------GLAFFQSANGVWLTD-----------FVDAKYISKDFVDAK  178   Chryseobacterium gleum ATCC 35910                        bacteria
    333381571  400  1     GKFLSLVLRHD--PAK-IELE--LDEN-GWANVK--EL--IEKCRKH----------RYHFSMEDLIEIVETND-KQRYSFNEK----------------------------------------------------------------------------------------------------------------------------------------------------------------RNKIRANQGHS--ID----------IDLGL------------------------------SAVEPP---EYLYHGTATRFL-SSIMEQG--IVKGSRRHVHLSKDK------------------------ETAIKVGARHG-KPVILTIMSGKMYQ-D------------GILFYQSDNGVWLTN-----------YVDVKYILKQIVDVK  178   Dysgonomonas gadei ATCC BAA-286                          bacteria
    213962768  404  13    SKFLSLVLRHH--PEA-IGIS--LDTH-GWAEVN--VL--IKNMKRK----------FPVFSLKILEEIVATDS-KQRYAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------NTKIRANQGHS--LA----------VTLEL------------------------------QPQTPP---ECLYHGTASRFV-ESILKSG--LQKQTRQHVHLSMDI------------------------ATATKVGARHG-KPVIFKVNTIAMHK-A------------GYVFYLSANGVWLTD-----------EVPPKFLNLIVNNPK  181   Capnocytophaga sputigena ATCC 33612                      bacteria
    163814521  405  4     SRFMSLILRHR--PES-IGIS--LDEH-GWANVD--EL--LSGIGEQ-----------HPIDMDMLEEIVRADK-KQRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTLIRANQGHS--IP----------VDVEL------------------------------DEVSPP---EELWHGTGEKYV-QDIETEG--LLPKSRLYVHLSNDR------------------------DTAFKVGQRHG-KPVLYIVRSGEMYR-D------------GYKFYLSKNGVWLTK-----------AVPVKYLQKQAVPVK  179   Coprococcus eutactus ATCC 27759                          bacteria>firmicutes
    323140426  406  3     GRFLALVLRHK--PQA-VGIE--LDAH-GWAQVE--AL--LAAFNR-----------IEAFNMLMLEQIVAEDG-KQRFAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------KKRIRANQGHS--VK----------VDVEL------------------------------WEVAPP---ELLYHGTGVKYV-ASINRQG--LIARQRLYVHLSANV------------------------ETAHNVGKRHG-EPFIYVVLAGEMAR-A------------GYKFYLSANGVWLTE-----------SVPKKFLRELEGALD  176   Phascolarctobacterium sp. YIT 12067                      bacteria>firmicutes
    154497918  407  11    SKYMSLILRHK--PQV-IGIH--LDAH-GWADVN--AL--LAGISRK-----------YSINRDILDEIVSRDE-KQRYSFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--IQ----------VDVEL------------------------------TLTEPP---EMLCHGTARRFA-ASIEAQG--LLSGSRLYVHLSPDQ------------------------ETAEKVGRRHG-EPVIYLVDAGQMHR-D------------GYCFYLSANGVWLTK-----------VVPATYLKRLEDRLT  183   Pseudoflavonifractor capillosus ATCC 29799               bacteria>firmicutes
    167749542  410  7     SRYMALLLRHK--PEI-AGLV--LDKQ-GWADVD--ML--LKCISEN----------MEPVSFERLCEIVKNDS-KQRYSLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------KSRIRANQGHS--VN----------VDVGL------------------------------KATVPP---EYLYHGTATRFV-ESIDSGG--IIRKTRLYVHLSRDT------------------------ETATQVGMRHG-KPFIYRVKSGEMAR-D------------GYVFYLSENGVWLTE-----------NVPVKYLEKTWQDDA  176   Eubacterium siraeum DSM 15702                            bacteria>firmicutes
    210621794  412  4     SRFISLILRHK--PET-IGIT--LDEH-GWANVE--EL--IVGVNKK-----------YPIDMQILEKIVDEDD-KNRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTMIRANQGHS--IS----------VDVEL------------------------------KKLNPP---DILYHGTGEKYV-ESIEKQG--LIRKNRLYVHLSNDI------------------------ETAEKVGKRHG-KPIIYEIDCKKMVE-N------------GIEFLKSENNVWLVE-----------SVPVKYLKKLSVPVK  175   Clostridium hiranonis DSM 13275                          bacteria>firmicutes
    336428119  414  1     ---MSYLLRHD--KDF-------IDEH-GWAPVT--EV--IHTLKKE----------WPEFNEECLSEIVRTDE-KGRYSYDEA----------------------------------------------------------------------------------------------------------------------------------------------------------------GVRIRANQGHS--VP----------VDVEL------------------------------KEAEPP---EILYHGTADRFL-NAIMEEG--LTGRSRIYVHLSSTT------------------------ETAVNVGKRHG-KPVVLKIYAGRMRD-A------------GYKFYLSQNQVWLTQ-----------KVPVEYIETLYPEQG  163   Lachnospiraceae bacterium 3_1_57FAA_CT1                  bacteria>firmicutes
    225388916  415  1     SVLISLVLRHK--PEA-AGIS--LDEH-GWADIE--TM--MAGMNAS----------GHRIDREMLEEIVRTDE-KGRYSLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--VP----------VDVEL------------------------------SPVQPP---EILYHGTAERFA-HAIREGG--LLPMGRLYVHLSKDV------------------------ETVVKVGSRHG-KPVVFEVESGRMYR-D------------GIPFYLSCNGVWLTK-----------AVKPRYLKGREVKPR  178   Clostridium asparagiforme DSM 15981                      bacteria>firmicutes
    317056274  418  13    GRFISLVLRHE--PSA-AGIV--LDAE-GWADVD--EL--IHGICNT----------GRKLDMETLERIVRENN-KQRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRANQGHS--IN----------VVINM------------------------------KIMSPP---EVLYHGTSEAFI-ESIKEKG--ISKMSRQYVHLSEDM------------------------DSAVKVGSRHG-KPAVLVIDTAKMSA-D------------GFVFRISENGVWQSD-----------DIPWKYVTEIKYPWK  180   Ruminococcus albus 7                                     bacteria>firmicutes
    167769835  419  12    GRFLSLVLRHN--PAA-AQIT--LDEH-GWADVE--AL--LAGCARA----------GRRIGRDTLERIVRENS-KQRYSFNGD----------------------------------------------------------------------------------------------------------------------------------------------------------------HTKIRANQGHS--IA----------VDVEL------------------------------RQAQPP---ARLYHGTAMRFL-ESIRAQG--ITRQSRQHVHLSADY------------------------PTALAVGSRHG-RPVVLAIDAAAMAR-D------------GYVFYRSENGVWLCE-----------RVPWSYVLEDGAGLA  179   Anaerotruncus colihominis DSM 17241                      bacteria>firmicutes
    260889106  421  2     GKFISLILRHK--PEM-IGIE--LDRN-GWANVD--EL--INGINRS---gdvengkEERINFEILEEIVRNNS-KKRYEFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------FTKIRACQGHS--ID----------VDLEL------------------------------KAVKPP---RILYHGTADRFL-EQIKKEG--LKKKSRQFVHLSETE------------------------ETAYSVGQRHG-KPFIIKVLAEKMYE-D------------GKEFFISKNGVWLTD-----------DIEVKYLEFDDIEVK  186   Leptotrichia hofstadii F0254                             bacteria>fusobacteria
    225620034  422  12    SKFVSLVLRHK--PEY-IGLE--LSKD-GWANVY--EL--IEKIKSK----------GRNINKDILERVVLYND-KKRFRFNEN----------------------------------------------------------------------------------------------------------------------------------------------------------------HTLIRANQGHS--IN----------VDLQF------------------------------EEKEPP---EILFHGTSINNI-DSIKHEG--IKKMNRLHVHLSLAE------------------------ETAKKVGERHG-KPTIIKINSKQMYE-D------------GIKFYLSENKVWLCD-----------YVDPKYIIEVIVDPK  182   Brachyspira hyodysenteriae WA1                           bacteria>spirochaetes
    167757534  423  8     GKFISLILRHK--PEL-IGLK--LDYH-GWAKVD--EL--LLGINNS----------GRFINRTLLDEIVMTNN-KQRYQYNED----------------------------------------------------------------------------------------------------------------------------------------------------------------HTKIRANQGHS--IK----------VDIEL------------------------------IEKIPP---EYLYHGTAFKYL-NKIEQEG--IKKMKRLYVHLSKDI------------------------ETAFKVGSRHG-KAIVLVIDTKAMCE-D------------GCKFYYSQNGVWLTE-----------DIDYKYVMEVIKDYK  176   Clostridium ramosum DSM 1402                             bacteria>firmicutes
    237742025  426  5     GRFISLILRHK--PET-IDLK--LDKN-GWANTK--EL--IEKISKS----------GREIDFEILERIVNENN-KKRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRAVQGHS--ID----------VNLEL------------------------------KEVVPP---AILYHGTAFKNL-ESIKKEG--IIKMSRQYVHLSADV------------------------ETAKNVATRHSGKYIIFEIDTEAMLK-E------------NYKFYLSENKVWLTD-----------FVPCKFIKFDFVPCK  179   Fusobacterium sp. 4_1_13                                 bacteria>fusobacteria
    110800227  428  7     SKYISLILRHK--PEE-IGLK--LDEH-GYLGVL--DL--IEGLNKS----------YEGFSMDDLERIVREDS-KGRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KSKIRANQGHS--IK----------VDLGL------------------------------EPIKPP---KVLYHGTGRKYL-ESILKNG--LIKKERNYVHLSKDI------------------------ETASIVGKRHG-DLVILEVDSESMFN-D------------GIKFYLSKNNVWLCN-----------YVPKKYIKELNLEEV  177   Clostridium perfringens ATCC 13124                       bacteria>firmicutes
    150018230  429  10    SKFISLILRHK--PEE-IGLT--LDEY-GYISTP--DL--IKGLNKK----------GYKVTISDIERIVAEDG-KQRYSFNND----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIKANQGHS--IK----------VNLEL------------------------------QAIKPP---KVLYHGTASRFI-DSICKEG--IKKQNRQYVHLSADI------------------------ETATKVGKRHG-ELVIFKINSEQMNK-D------------GYKFFLSENKVWLTD-----------YVPVKYFEVFRTNVK  179   Clostridium beijerinckii NCIMB 8052                      bacteria>firmicutes
    224542154  431  1     SRRLSYILRHC--PES-IDLE--LDDH-GYGDVN--KI--LEAL---------------NITIEDLDMIVREDE-KQRYSYNGD----------------------------------------------------------------------------------------------------------------------------------------------------------------HTRIRANQGHS--IP----------VNVDL------------------------------KEVQPH---DILYHGTATRFV-PSILEEG--ILSQTRIYVHLSQDI------------------------ETAMTVGSRHG-EPYVFTIDTKQMYE-D------------GYKFYLSENNIYLTK-----------IIPAKYLKASTIPAK  168   Catenibacterium mitsuokai DSM 15897                      bacteria>firmicutes
    255103268  433  6     SIFISLILRHK--PET-IGIK--LDDY-GYADVN--EL--IEKINNT----------GRNINIEILEQIVKEDN-KQRYSFNDD----------------------------------------------------------------------------------------------------------------------------------------------------------------RSKIRANQGHS--IN----------VNVEL------------------------------RELEPP---KYLYHGTATRFL-DNIKNEG--IIKQSRLYVHLSRDI------------------------DIAVKVGKRHG-TPVILKINTGKMYE-N------------GYKFYLSENNVWLCE-----------YIPFKYVEIFEIPFK  177   Clostridium difficile QCD-63q42                          bacteria>firmicutes
    149175185  443  1     SKFLSLILRHQ--PET-VGIT--LDES-GWVDVD--IL--LAAMSQQ----------GKGMSRATLNTVVQSND-KQRFSFNAE----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRANQGHS--IS----------VDLGY------------------------------TTAVPP---EILFHGTPEKFI-EPISREG--LKKMNRHHVHLHVDE------------------------QTSIAVGRRRG-RPVLLQVRAREMHQ-A------------GCEFFVTPNQVWLTE-----------SVPVEYIDFPSVPVE  181   Planctomyces maris DSM 8797                              bacteria>planctomycetes
    87311897   444  4     SKFLSLVLRHQ--PDK-IGIE--LDEQ-GWVEVA--TL--LAAIRRE----------SRPLTLAQLQEVVTRND-KQRFMFSSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRAVQGHS--IE----------VELGY------------------------------EAAAPP---EYLLHGTPEQSV-AIILETG--LKKMKRHHVHLHHDR------------------------QTASAVGQRRG-KPVLLQIAAGRMHA-D------------GYSFYVTPNQVWLTD-----------EVPPAYLSILEVPPA  183   Blastopirellula marina DSM 3645                          bacteria>planctomycetes
    163849264  446  25    SKFLSLVLRHR--PEQ-IGLS--LDQH-GWAEVD--EL--IRCANRH----------GLPLSRAQLEQVVAEND-KQRFAFSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRANQGHS--LP----------VDLQL------------------------------TPAQPP---PVLYHGTAERFV-ESIKRDG--LLPGKRQYVHLSQDE------------------------TTALTVGQRHG-RPVVLTVHAAAMTA-A------------GYVFYVSANGVWLTK-----------QVPARFIEFPAVPAR  205   Chloroflexus aurantiacus J-10-fl                         bacteria>chloroflexi
    171913881  447  4     SKFLSLVLRHK--PEE-IGLV--LDEA-GWASTD--KL--IDACNRH----------GPGLDLPTLQLLVNTNE-KKRFEFNAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GSRIRASQGHS--VE----------VDLGY------------------------------TPQVPP---AVLHHGTVEDFL-DPIRSQG--LVKGERHHVHLSADP------------------------AIARIVGTRHG-KPVVLTVQASTMHT-A------------GHPFYLSTNGVWLTD-----------HVPARFIDFPSVPAR  183   Verrucomicrobium spinosum DSM 4136                       bacteria
    223939130  449  7     SKFLSLVLRHE--PGR-IGIQ--LDSA-GWVDVD--EL--LRACTAH----------QFPFSRDELNQVVATND-KKRFAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRANQGHS--VE----------VELQY------------------------------EPSVPP---EILYHGTADRFL-ASIQQDG--LIKGNRHHVHLSTEL------------------------STAISVGQRHG-RPLVFRVLAGQMHR-S------------GHQFFVSANGVWLAD-----------HIPANFLQIHTGEQN  177   Pedosphaera parvula Ellin514                             bacteria
    196229950  451  1     SKFLSLVLRHE--PEK-VGLE--LDSA-GWVEVE--ML--LAACRQH----------GVAIERAELEEIVVTNE-KKRFAFSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRANQGHS--IE----------VSLGY------------------------------TPQVPP---ARLFHGTATRFL-DSIRSDG--LKKMERHHVHLSADE------------------------ETAHKVGQRHG-KPLILLIKADAMHA-A------------NHSFFLSENGVWLTD-----------AVPVAFIEFPEDKTL  181   Chthoniobacter flavus Ellin428                           bacteria
    284038905  453  4     SKLLSLALRHK--PET-TGII--LDKN-GWTDVD--LL--IAKLQAQ----------SYPVNFEQLCYIVDTNN-KSRFAFNND----------------------------------------------------------------------------------------------------------------------------------------------------------------KSKIRANQGHS--VE----------VDLGY------------------------------MTEEPP---HFLYHGTATRFI-NQIIIEG--LKKMSRHHVHLSADE------------------------LTALRVGERHG-EPIVLTVKAKEMAA-N------------GHVFHRSENGIWLTD-----------FVPPSYLIYEFVPPS  181   Spirosoma linguale DSM 74                                bacteria
    118591032  454  6     SKRLSFWLRHK--PED-AGLT--LSHD-GWADVS--AV--LKAFSTL----------KLDCNRDQLERVVETND-KKRFEFSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRARQGHS--VD----------IDLGL------------------------------TALTPP---EILFHGTATRFL-PLILTEG--LKPMARHHVHLSPDR------------------------STALKVGSRHG-KPAVLQVAASAMQA-D------------GHTFYRTENGVWLTD-----------SVPATFLTQTETVST  176   Labrenzia aggregata IAM 12614                            bacteria>proteobacteria>alphaproteobacteria
    256394652  458  5     SKRMSSWLRHH--PEA-IGLE--MDGA-GWVRVD--EL--LAKAAAR----------GQAFSRAQLEEVVAENT-KKRFEFDET----------------------------------------------------------------------------------------------------------------------------------------------------------------ETLIRARQGHS--IP----------VELGY------------------------------ATAEPP---EVLFHGTAQNTL-TLIWRDG--LLPMKRHAVHLSPDK------------------------ETAVKVGSRHG-KPAVLAVAAARMHA-E------------GYTFFVTGNGVWLTD-----------AVPAEYLREVPALGE  173   Catenulispora acidiphila DSM 44928                       bacteria>actinobacteria
    257063188  459  1     SRHLSYLLRHH--PEA-AGLH--MDEH-GWVRVD--EL--VAAVAQK-----------HSFDQTTLERIVATDK-KGRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------RTLIRANQGHS--IP----------VDVEL------------------------------ACVTPP---DRLFHGTATRFA-ESIERQG--LLPQNRLYVHLSPDP------------------------ETAMVVGARHG-KPMVYVVDAKAMSA-A------------GHRFFLSVNGVWLVK-----------TVPPEYLTRMTVPPE  177   Slackia heliotrinireducens DSM 20476                     bacteria>actinobacteria
    149919906  460  1     GKRLAWLLRHE--PEA-WGLR--VDAH-GWMEVE--AL--LAAFAER----------GHALSRAELETHVAADG-KQRFILSSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GARIRAVQGHS--IA----------VDLEL------------------------------DERPPP---AQLFHGTPRRFV-DSILREG--LIPKARHHVHLSADE------------------------ATARQVGARRG-PPVILLVDAATMAA-D------------GHRFFVSANGVWLCE-----------RVPPEHLRVANVPPE  173   Plesiocystis pacifica SIR-1                              bacteria>proteobacteria>deltaproteobacteria
    302525419  463  1     SKRLSRHLRHD--PGG-LGLT--LAPG-GWVPVD--EL--LAALARN----------RFPVSRAELDEVVANCA-KQRFAFDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------GTLIRASQGHS--VR----------VDLEL------------------------------SDAVPP---EILYHGTATRFL-PSIRAEG--LRPMKRHAVHLSATR------------------------ETAWKVGSRHG-KPVVLTVAAGEMAA-R------------GHVFQVSDNGVWLAP-----------AVPAEFLTVAEVPAE  178   Streptomyces sp. AA4                                     bacteria>actinobacteria
    300784169  464  5     SKRLSRHLRHD--PAA-LGLT--LTSD-GWAPVD--AL--VRALA---------------ITRAQLDEVVEKNS-KRRFAFDET----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRASQGHS--VP----------VELGL------------------------------PDTTPP---DVLYHGTVAKYL-DAIFREG--LRPMNRHAVHLSATV------------------------ETAGIVGARRG-KPVILRVDAAAMAA-E------------GHPFQISANEVWLTP-----------SVPPHHLASLTVPPH  168   Amycolatopsis mediterranei U32                           bacteria>actinobacteria
    297564265  466  1     SKLLSRVLRHD--PAR-VGVR--LDPR-GWAGVD--EL--LAGCRRA----------GVRLSRAALQEVVDTND-KKRFVLSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRAQQGHS--VR----------VDLGL------------------------------EPSTPP---ALLYHGTVGRLL-PAITAEG--LRPMRRHDVHLSPDT------------------------ATARRVGARRG-APVVLTVASGRMHG-D------------GHVFRVTGNGVWLVP-----------AVPPEYLGEPVVPPE  181   Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  bacteria>actinobacteria
    256379719  467  1     SKRMSRCLRHD--PGR-YGLA--LDAA-GWVDLG--GL--VRALR---------------TSREAVLEVVERNN-KRRFTVR------------------------------------------------------------------------------------------------------------------------------------------------------------------GDRIRADQGHS--VA----------VELGL------------------------------AQVEPP---GVLFHGTNAKAL-PDVLVEG--LRPMNRHAVHLSTDL------------------------ATATQVGARRG-RPVVLEVDAARMHA-E------------GHAFSVSENGVWLVA-----------AVPPDYLRQRAVPPD  171   Actinosynnema mirum DSM 43827                            bacteria>actinobacteria
    182437433  468  1     SKYLSKHLRHQ--PER-IGLT--LDEN-GWVAVE--EL--LRAAARH----------GFAFSRAELDHVVAAND-KRRFTVENG--------------------------------------------------------caadgvh-------------------------------------------------------------------------------------------------GDRIRANQGHT--VA----------VDLDL------------------------------PPAEPP---AHLYHGTVARVM-DAIRTEG--LRPMARHHVHLSPDR------------------------ETATRVGARRG-RPLVLTVDAGAMHR-A------------GHVFRVSANGVWLAD-----------AVPPRFLLADAVPPR  185   Streptomyces griseus subsp. griseus NBRC 13350           bacteria>actinobacteria
    284988800  471  1     SKRLSYVLRHA--PGS-VGLT--LDAA-GWADVD--AL--LAALG---------------WTRAELERVVATND-KRRFALDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRASQGHS--VA----------VDLGY------------------------------AAQTPP---PVLFHGTAERNV-PAIEAGG--LRPGRRHAVHLSPDE------------------------VTARRVGARHG-RPVVLRVDAAGMAA-V------------GAVFTRSANGVWLVD-----------AVPPAFLTVVGVPPA  173   Geodermatophilus obscurus DSM 43160                      bacteria>actinobacteria
    311899069  473  7     SKTLSRILRHD--PGA-VGIT--LDAA-GWVEVD--AL--LAALARH----------GRRLSRAELDHVVATND-KRRFAYSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GRSIRASQGHT--VE----------VDLGL------------------------------PAATPP---DTLFHGTAERTL-RHVLAEG--LRPMSRRDVHLSADT------------------------ETAVKVGSRHG-RPVVLAVDAAAMAR-D------------GYEFRASANGVWLTD-----------AVPVGYLRRTPVPVG  184   Kitasatospora setae KM-6054                              bacteria>actinobacteria
    296130288  477  5     SRFLSYVLRHR--PDA-AGLT--LDAA-GWVDVD--VL--LAALAAH----------GHTATPEDLRYLAEDVPGKKRLELRD-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-RVRAAQGHS--VR----------VDLGL------------------------------APVVPP---ATLFHGTATRFL-DRILVDG--LRPMSRQHVHLSADR------------------------ATATDVGSRHG-RPVVLLVDAAAMHA-G------------GAAFYRAANGVWLTD-----------AVPPEHLRREVVPPE  172   Cellulomonas flavigena DSM 20109                         bacteria>actinobacteria
    330469061  478  3     SKFLSYVLRHR--PDA-VGVT--LDEA-GWVPVD--VL--LAALARH----------GRPVTPALLDQLVGNTD-KQRFEVRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-RIRAAQGHT--IA----------VDLQL------------------------------APAVPP---TVLYHGTVARFL-PGIRVEG--LTSGERTHVHLSSDL------------------------DTAARVGARRG-KPVVLRIDAAGMHV-A------------GLVLYRAANGVWLTR-----------HVPPRFITLPSVPPR  178   Verrucosispora maris AB-18-032                           bacteria>actinobacteria
    159038434  479  5     GKALAYVLRHR--PDA-VGLQ--LDSA-GWVEIP--AL--LSAMADA----------GHTIGEADLDRIVAGSD-KKRYEVRA-----------------------------------------------------------------------------------------------------------------------------------------------------------------R-RIRAAQGHS--VR----------VELGL------------------------------EPTIPP---AVLYHGTVARFL-EAIRREG--LRPGERTHVHLSADA------------------------STARQVGERRG-APVVLEIEAKRMYA-D------------GHSFLLAANGVWLVA-----------HVPPDYLALTDVSPD  175   Salinispora arenicola CNS-205                            bacteria>actinobacteria
    159901400  482  1     SKYLSKHLRHQ--PER-LGLT--LEPG-GWVGVE--QL--LAACAAN----------NVAISLAELHEVVEQNN-KQRFGFDPT----------------------------------------------------------------------------------------------------------------------------------------------------------------GQKIRAHQGHS--VT----------VDLGL------------------------------VAQQPP---IILYHGTAKHNL-AIILRDG--LRPMQRQHVHLSRDR------------------------ATALQVGARHG-QAVILIVQADELFQ-A------------GQAFFCSDNGVWLTT-----------AIDPAYLALERIDPA  178   Herpetosiphon aurantiacus ATCC 23779                     bacteria>chloroflexi
    67921554   483  20    SRFLSYHLRHA--PEK-LGLE--LEPG-GWISTE--KL--LKACQNT----------KFTLTFSDLETVVKDND-KQRFSFNEA----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRANQGHS--VN----------IDLQL------------------------------EPLIPP---VILYHGTHQKVV-KTILKEG--LKKMARHHVHLSERK------------------------ETALKVGSRRG-KPVIFVIKAQQMSE-D------------GCIFYCSDNGVWLVD-----------YIDPKYLTIKYIDPK  197   Crocosphaera watsonii WH 8501                            bacteria>cyanobacteria
    300868996  484  1     SKYLSRHLRHT--PER-LGIE--LSPG-GWVAVD--RL--LAASSDR----------NFPIQLAELKEVVAKND-KQRFSFDST----------------------------------------------------------------------------------------------------------------------------------------------------------------GTLIRANQGHS--IT----------VDLQL------------------------------EPAVPP---DVLYHGTGKGAV-ESILKSG--ICKMSRHHVHLSVNI------------------------KTAQKVGARHG-LPVVFTIAAEAMHD-R------------GYTFYCSENGVWLVE-----------YVPPEYLKLTYVPPE  180   Oscillatoria sp. PCC 6506                                bacteria>cyanobacteria
    307150228  485  1     SKYLSYHLRHH--PEE-LGLE--LAPG-GWVEVE--KL--LAACLEA----------QFPLTREELEEVVTNND-KQRFSFDQT----------------------------------------------------------------------------------------------------------------------------------------------------------------KTLIRANQGHS--VP----------VDLQL------------------------------TSLAPP---EILYHGTSTKAV-PSILSQG--LLKMARHHVHLSTTI------------------------EAARKVGQRQG-KPVVFELDAAAMYQ-A------------GYQFFVSENGVWLVE-----------TVPPAYLRQIYPLLV  178   Cyanothece sp. PCC 7822                                  bacteria>cyanobacteria
    168698114  489  1     SKFLSKVLRHE--PES-AGLT--LERG-GWVPIV--DL--LSGLARS----------GTRISREDLDVVVSECE-KQRFAIDDT----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--AE----------VELQF------------------------------EPVEPP---TELYDGTTETNI-SSVLRDG--LLKMARHHVHLSADG------------------------TTARKVGGRHG-KPVVITVHAAQMSA-D------------GYIFYRSANGVWLVD-----------HVPPQYLRLDHVPPQ  178   Gemmata obscuriglobus UQM 2246                           bacteria>planctomycetes
    302868056  490  1     SKRLSLALRHR--PDT-FGLR--LDRA-GWVPVA--DV--LAGLR---------------ISRAQLDAVVAGND-KQRFAVEAGpd-------------------------------------------------------------------------------------------------------------------------------------------------------------gADRIRANQGHS--VP----------VDLGL------------------------------TPAAPP---PRLFHGTGEAVL-DAIRAQG--LRRGGRHHVHLSPDV------------------------ATARRVGARRGGAVVVLTVDAAAMAE-A------------GYLFYRSANGVWLTD-----------TVPPPYLLTDTVPPP  177   Micromonospora aurantiaca ATCC 27029                     bacteria>actinobacteria
    320333790  491  1     SRRLSYLLRHA--PHE-AGLT--LEPG-GWVRVD--DL--LAGLRRL----------GVAATREAVETVVRTND-KRRFSLDGA----------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRANQGHS--VP----------VDLEL------------------------------TPSVPP---DALYHGTVRAAT-GDIFREG--LRPMARHHVHLSPDT------------------------ATAVRVGARRG-RPVVLRVDAAGMHA-A------------GHRFYCSENGVWLTD-----------TVPPAFLSVLPADGT  177   Deinococcus maricopensis DSM 21211                       bacteria>deinococci
    226355053  492  1     LSYL---LRHA--PQK-AGLT--LEPG-GWAPLA--PV--LAHLN---------------VTRAQVERVVATNN-KQRFTLN------------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRANQGHS--VE----------VDLRL------------------------------PLTVPP---ARLYHGTHPGVL-AAIQHEG--LRPMQRHHVHLSSDP------------------------ETARQVGARRG-TPVILTVQSGAMYD-A------------GHSFYRSDNGVWLTE-----------AVPPEFLNFPAVPPE  171   Deinococcus deserti VCD115                               bacteria>deinococci
    325283812  495  1     SKRLAYLLRHA--PHE-AGLT--LARG-GWVPLA--PL--LAHLR---------------VTRGQVERVVREDE-KGRFGLSEG----------------------------------------------------------------------------------------------------------------------------------------------------------------GDKIRATQGHS--VP----------VDLGL------------------------------EPQVPP---ATLYHGSHQGAR-VGITRHG--LKAMSRHHVHLSADT------------------------DTALKVGLRRG-WPLLFAVDAARLHA-D------------GFTFYRSENGVWLVD-----------AVPPAYLSELPTPGQ  170   Deinococcus proteolyticus MRP                            bacteria>deinococci
    291300690  1    6     SKKLSYVLRHD--PAS-IGVT--VDAA-GWIDID--TL--LAALTRH----------GTTVSRQQLDAVVATND-KQRFTIDA------------------------------------------------------------------------------------------------------------------------------------------------------------------ERIRANQGHS--IT----------VDLGL------------------------------KARVPP---ARLFHGTATTRL-ASILDTG--LRRGTRHHVHLSTDT------------------------ATAAKVGSRHG-IPAVLTIDAAGMHD-H------------GHEFFVSANGVWLVD-----------SVPATYLTAQSVPAT  181   Stackebrandtia nassauensis DSM 44728                     bacteria>actinobacteria
    258545015  2    12    SKRLSFILRHQ--PQS-IGIT--LDAQ-GWVDVA--IL--LQQLNAH----------GTAIDRALLDHVVATNP-KQRFSYDAS----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--VA----------IDLAY------------------------------TPCVPP---ETLYHGTARSTF-AAIRESG-GLDKRTRHHVHLSSDV------------------------ETAMKVGQRHG-KPLVLRIAAGEMQR-D------------GHVFYQSDNGVWLTE-----------HVPLAYISADAVPLA  181   Cardiobacterium hominis ATCC 15826                       bacteria>proteobacteria>gammaproteobacteria
    226330224  4    8     SRFLSYILRHA--PES-IGLT--LDDQ-GWGEIS--TL--ISLAQKN----------GTPLTLKLIKDVVETND-KKRFAISED----------------------------------------------------------------------------------------------------------------------------------------------------------------GFFIRAVQGHS--LK----------TTVDY------------------------------QAITPP---KILYHGTATRFI-TSIFDQG--LIPNGRQYVHLSQDY------------------------KTAVNVGNRHG-KAVVLTVDSEKMFS-E------------GFEFYQADNGVWLTL-----------SVPAKYLKIDENEAK  176   Proteus penneri ATCC 35198                               bacteria>proteobacteria>gammaproteobacteria
    225075180  5    3     SKFLSFILRHH--PEQ-IGIT--LDKD-GWVDID--TL--LTQVNHP-----ergftGNPLTYEVLLEVVENND-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRAAQGHS--TA---------QVQVEH------------------------------KVATPP---QILYHGTAERSV-PSIMEQG--LHSASRHFVHLSADA------------------------ATAVNVGSRHG-KPVVLTIDTVAMLA-A------------GHQFYLADNGVWLTE-----------NVPPQFILTENVPPQ  186   Neisseria flavescens NRL30031/H210                       bacteria>proteobacteria>betaproteobacteria
    308446799  6    4     SKFLSLVLRHQ--PET-IAIQ--LDSE-GWTDVH--IL--LQQMIKH----------KRPLKLVELIEVVESSD-KKRFQLSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------QSKIRAVQGHS--SA---------QVQREY------------------------------AAITPP---DTLFHGTATRFV-NSILEKG--LISGERHHVHLSADL------------------------VTAQKVGQRHG-KVIIFILDTKQMHQ-D------------GFRFYCAENGVWLTE-----------QVPIKYLKLFESNQK  183   Caenorhabditis remanei                                   eukaryota>metazoa>nematoda
    225023628  9    9     SKFLSYILRHH--PEA-IGLT--LDGE-GWADVD--EL--LTQAAAH----------GRNISLPLLHEVVATNN-KKRFTLSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GGKIRAEQGHS--TA---------QVDIAY------------------------------TETEPP---EILYHGTAQRFA-EAIEEQG--LLPGSRHYVHLSGDV------------------------ETAVSVGSRHG-KPLVLEVQAGLMRQ-Q------------GFVFYLTANKVWLIK-----------EVPSQFLRRMEVPSQ  178   Eikenella corrodens ATCC 23834                           bacteria>proteobacteria>betaproteobacteria
    15891357   11   6     SKFLSYVLRHA--PES-IGLV--LDSQ-GWADVA--DL--LAKANAS----------GTPLDEAGLRAVVAESD-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRAAQGHS--VK----------VDLGQ------------------------------PPVEPP---PQLFHGTATRFL-EPILREG--LRPGERQQVHLSADR------------------------TTALAVGQRHG-KPVVLIVDAGQMFA-D------------GCRFYLADNGVWLTD-----------AVPFSYLTVSADSSA  174   Agrobacterium tumefaciens str. C58                       bacteria>proteobacteria>alphaproteobacteria
    213966822  12   1     SKLLSYVLRHA--PES-MGLT--LDRD-GWCEVD--EL--VGKANAN----------GHSFDRQALKEVVETNE-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GQRIRAAQGHS--TR---------LVQVQH------------------------------IEKEPP---ARLYHGTASRFM-ASIETQG--LIAGSRHHVHLTEDP------------------------ETALSVGKRYG-QPVLLAVDAKGMFE-A------------GVQFFQADNGVWLVE-----------AVPIEWLTKVADTVS  179   Pseudomonas syringae pv. tomato T1                       bacteria>proteobacteria>gammaproteobacteria
    32476856   36   4     SKFLSLVLRHQ--PGV-IGMT--LDEQ-GWLEID--GL--IANANTR----------GKKLTLELIHEVVATND-KKRFVLSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRASQGHS--VA---------GVDLNL------------------------------TEANPP---ATLYHGTVDAFL-PRIREQG--LQKRSRNHVHLSADE------------------------ATATNVGSRRG-KPKLLLIAAQRMHQ-D------------GHIFYLSENEVWLVD-----------SVPPTYLTFPTVPPT  183   Rhodopirellula baltica SH 1                              bacteria>planctomycetes
    325928686  16   7     SKFLSYVLRHA--PQS-IGLT--LDRE-GWADID--AL--IAAATAA----------GRALDADLIRAVVSSND-KQRFALSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRQIRAVQGHS--TA---------TVALVH------------------------------MPRTPP---SMLYHGTATRFL-EAILAQG--LQPGQRHHVHLSADP------------------------KTATTVGARHG-APSVLRVHSLQMHE-D------------GHVFYQADNGVWLTR-----------HVPPNYLHLVQVPPN  180   Xanthomonas perforans 91-118                             bacteria>proteobacteria>gammaproteobacteria
    170683612  18   5     SKFLSFVLRHK--PES-IGIV--LDRE-GWADID--KL--ILCAQKA----------GKRLTRALLDTVVATSD-KKRFSYSSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRCIRAVQGHS--TS---------QVAISF------------------------------AEKTPP---QFLYHGTASRFL-DEIKKQG--LIAGERHYVHLSADE------------------------ATARKVGARHG-SPVILTVKAQEMAK-R------------GLPFWQAENGVWLTS-----------TVAVEFLEWPFMPAG  185   Escherichia coli SMS-3-5                                 bacteria>proteobacteria>gammaproteobacteria
    260554979  19   1     SQYLSFILRHK--PEE-IGLT--LDRE-GWANIE--EL--ISKSQPV---------kNVALDEEIIKNIVSNSD-KKRFQISDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKLIRAVQGHS--TT---------SVDITL------------------------------NKLKPP---TYLYHGTAQRFI-DSIKEQG--LISKDRQYVHLTENR------------------------DTALTVGARYG-KPEILVIDALKMHD-S------------GFEFFQAENGVWLSK-----------HVPIEFIAFKHVPIE  179   Acinetobacter baumannii ATCC 19606                       bacteria>proteobacteria>gammaproteobacteria
    330977809  21   1     SKFLSYVLRHE--PEA-IGLE--LSRD-GWADID--ML--IACAAKN----------EQVFDRDFLERVVAESE-KKRFLISED----------------------------------------------------------------------------------------------------------------------------------------------------------------RRYIRAAQGHS--NS---------SVSIQY------------------------------TQVVPP---EFLYHGTATRFL-ESIFKEG--LVAGARHYVHLSESK------------------------ETARSVGLRYG-KPIVLEIEALHMHN-L------------GFKFFQAENNVWLID-----------KVPASWLVLKGVPAS  179   Pseudomonas syringae pv. aptata str. DSM 50252           bacteria>proteobacteria>gammaproteobacteria
    172064765  25   29    SKFLSFVLRHA--PES-IGLQ--LDRE-GWASID--SV--LAGAITQ----------PFTLNREILHIVVSESD-KKRFEISAD----------------------------------------------------------------------------------------------------------------------------------------------------------------DQWIRAVQGHT--SS---------SVRREY------------------------------VEKQPP---EFLYHGTVERFL-DSILEQG--LHQGTRHHVHLSASI------------------------ETAISVGKRRG-KPVVLKIDSSRMYR-Q------------GFKFFLTENGVWLTG-----------AVPVDFIEILTVPVD  208   Burkholderia ambifaria MC40-6                            bacteria>proteobacteria>betaproteobacteria
    322832748  27   1     SKFLSYILRHK--PDT-IGLQ--LDVE-GWADIN--SL--ILGAAKE----------GRVLDQAIIQTVVNSSD-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GQRIRAVQGHS--TP---------DVNLQH------------------------------MEKKPP---EFLYHGTATRFL-ESILQQG--LIAGSRHHVHLSQDI------------------------TTAVAVGQRYG-KPAVLKVEALRMHQ-Q------------GFNFFQAENGVWLTN-----------HVPNFFIYQEHVPNF  179   Rahnella sp. Y9602                                       bacteria>proteobacteria>gammaproteobacteria
    107099046  29   1     SKFLSYVLRHQ--PEA-IGLT--LDGE-GWADID--AL--IAGAARD----------GRALDRVLLGAVVENND-KKRFALSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------DQRIRAVQGHS--HA---------AVAIAY------------------------------APAVPP---AVLYHGTASRFL-DSIRERG--LVPGSRHHVHLSARR------------------------ATALEVGRRYG-SPVLLEIDARDMHL-A------------GHLFHQAENGVWLTE-----------RVPVRFIREARVPVR  179   Pseudomonas aeruginosa PACS2                             bacteria>proteobacteria>gammaproteobacteria
    70733133   30   1     SKFLSYVLRHE--PQA-IGLE--LDSE-GWGDID--AL--ISGAAKN----------GRQLSRELIELVVEGND-KKRFALSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------SRRIRAVQGHS--NK---------AVQLQL------------------------------EAKQPP---AVLFHGTATRFM-DSINEKG--LIPGSRHHVHLSQEI------------------------DTARAVGQRYG-KVVILQIDAQAMQA-Q------------GFTFYQAENGVWLTD-----------QVPVGFIKALQVPVG  179   Pseudomonas fluorescens Pf-5                             bacteria>proteobacteria>gammaproteobacteria
    53718401   35   10    SKFLSYVLRHR--PDS-IGVT--LDAQ-GWADVS--EL--LTKAAAA----------GMALTLDELKQVVAEND-KKRFVLNDD----------------------------------------------------------------------------------------------------------------------------------------------------------------ATRIRAAQGHS--VD----------VDLQL------------------------------PVKAPP---PVLYHGTVGKSM-ADIRKQG--LTPMNRHDVHLSPDR------------------------ETATRVATRRG-KPVILVIETYPLLR-D------------GYQFRVSDNGVWLVP-----------EVPAKYIKFPGVPAK  183   Burkholderia pseudomallei K96243                         bacteria>proteobacteria>betaproteobacteria
    307946056  39   6     SKFLSYVLRHK--PEA-IGLS--MDEA-GWVAID--EI--LEKAN-------------RPISRELIEQIVAEND-KQRFAISSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRQLRANQGHS--VS----------VDLKL------------------------------KPKEPP---AELFHGTASRFL-DSIFEKG--LVPGTRQHVHLSANV------------------------ETALKVGQRHG-KPVILAVPALEMHQ-S------------GHFFFLSENGVWLTH-----------AVPANKLVLHDNNAN  176   Roseibium sp. TrichSKD4                                  bacteria>proteobacteria>alphaproteobacteria
    329847506  41   1     SKFLSLVLRHQ--PET-IGLT--LDAH-GWTSVD--DL--LKRMAAH----------GKFLTREKLERVVAEND-KKRYTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRAAQGHS--VK----------VDLAL------------------------------LPALPP---DILYHGTATRFV-ESIMTEG--LKPQSRQQVHLSLDY------------------------ATASKVGQRHG-KPYIFRVEAGRMQA-D------------GHLFFRADNGVWLTD-----------AVPPQYLIAPDSAAQ  178   Asticcacaulis biprosthecum C19                           bacteria>proteobacteria>alphaproteobacteria
    296114887  43   15    SKFLSLVLRHA--PER-IAIS--LDPQ-GWVETT--IL--IRQARRH----------GQTFDLPSLQRVVRDND-KQRFTLSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRAAQGHS--IA----------VDLAL------------------------------PPAIPP---AVLWHGTARTSL-ESIFRDG--LLPGRRRHVHLSNDE------------------------ATAMTVGTRHG-RAVVMRVAAGRMHD-D------------GLTLWRADNGVWLTD-----------GVPPCYLSFAGVPPC  188   Gluconacetobacter hansenii ATCC 23769                    bacteria>proteobacteria>alphaproteobacteria
    84499293   45   1     ------------------------------------------------------------MSRGHLVRLVADDN-KRRFTLSEG----------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRAAQGHS--LA----------VDLTL------------------------------APQSPP---AVLYHGTNRQSL-DSIFQSG--LLSGRRQFVHLSADV------------------------DTALDVGTRHG-KPIVLSVEAGAMSR-G------------GHQFWVADNGVWLTR-----------QVPAQFLAFAPRHDP  131   Oceanicola batsensis HTCC2597                            bacteria>proteobacteria>alphaproteobacteria
    84499284   42   1     SKFLSRVLRHE--PEL-IAIQ--LDPQ-GWVSVD--DL--LRRLKKV----------GHGMSREQLREIVETND-KRRFTLSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRAAQGHS--VD----------VDLGL------------------------------TPLVPP---EFLYHGTAAQNL-DAIFETG--LNPGRRRQVHLSPEP------------------------ETANRVGQRHG-KPTVLRVEASKMHA-D------------GFVFTCSDNGVWLTD-----------SVPAAYLGFGVMLAA  175   Oceanicola batsensis HTCC2597                            bacteria>proteobacteria>alphaproteobacteria
    84501233   44   1     SRFLSLILRHK--PEE-VGLK--LGPG-GWVRID--EL--LVAMKRA----------GRRLTRDHLIEIVEQND-KKRFTISSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRAAQGHS--LD----------VDLGL------------------------------PAQDPP---DELFHGTARAHL-DEIFSAG--IIPGRRRLVHLSVDI------------------------ATALTVGGRHG-KPVVLTVAAKAMHQ-D------------GHKFYRADNGVWLTD-----------HVPTSYLSFATIRTS  175   Oceanicola batsensis HTCC2597                            bacteria>proteobacteria>alphaproteobacteria
    221067794  50   35    SKFLSLVLRHS--PET-IGLT--LDEA-GWARTD--EL--LACLARS----------GRPTRLEELQRIVADNN-KQRYSFSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKHIRANQGHS--IK----------VELGL------------------------------EASSPP---AVLYHGTATRFL-DAIFHEG--LNRQSRHHVHLSDSV------------------------EVAAQVGSRHG-KLALLQVDAARMQG-E------------GHVFYRSDNGVWLTD-----------VVPVRYLLKLPSPVR  212   Comamonas testosteroni KF-1                              bacteria>proteobacteria>betaproteobacteria
    333912499  51   3     SKFMSLVLRHN--PGR-AGLA--LDAQ-GWVSID--AL--LRGAQAA----------GRNISPALLMEVVRSCP-KQRFAISAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRASQGHS--VQ----------IDLGL------------------------------QASVPP---QRLYHGTATRFL-DSILRTG--LDRRNRHHVHLTDNL------------------------ATARSVGQRYG-RLVLLEIDAARMHA-D------------ACLFYRSDNGVWLTD-----------SVAPHYLRVLAEEEH  179   Delftia sp. Cs1-4                                        bacteria>proteobacteria>betaproteobacteria
    158337724  53   2     SKFLSYILRHR--PEA-ISLE--LNAG-GWAAIS--EL--IQCASKH----------DHFLSEEIIKEVVVSND-KKRFKLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GQYIRANQGHS--IR----------VDLDL------------------------------LPLTPP---DVLFHGTATRFL-ASIMAKG--LLPSGRQHVHLSASY------------------------ETAIAVGRRHG-KPTVLEINAQKMQG-D------------GYLFYRSENGVWLTD-----------HVPAQYFVEVEVPAQ  177   Acaryochloris marina MBIC11017                           bacteria>cyanobacteria
    330983843  54   95    GRYLAAILRHKKISDN-IGLK--HDAQ-GWMSIA--DI--IEKSTAN--------rkAPPLSVEIIDLAVQHCD-KQRYAISPD----------------------------------------------------------------------------------------------------------------------------------------------------------------RCHIRAKQGHS--FP----------VDLGL------------------------------KAEIPP---VVLYHGTVDRFF-SSIMREG--LTPQKRQHVHLSHEKe-----------------------TALNVGGRRKG-EVIILEIDAKAMLA-N------------GHVFHLSENGVWLTE-----------AVPSQYINTEAVPSQ  277   Pseudomonas syringae pv. lachrymans str. M301315         bacteria>proteobacteria>gammaproteobacteria
    34497880   58   35    SRFLSLVLRHQ--PET-IGLQ--LDDQ-GWADIG--EL--LARLAAK----------GRNLGRKQLEKIVLDND-KQRFAISED----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRANQGHS--IK----------IDLGL------------------------------AACEPP---DRLYHGTASRFL-DAILAEG--LRPGQRQHVHLSADG------------------------QTARKVGARHG-KPVVLEIDARAMRQ-A------------GLAFYRSDNGVWLID-----------GVPPVFIRQTEARPV  203   Chromobacterium violaceum ATCC 12472                     bacteria>proteobacteria>betaproteobacteria
    83643039   59   15    SKFLSLVLRHQ--PEL-IQLP--LDAN-GWADIE--VL--LAGAARQ----------GVNISLQDVLEIVATND-KQRFALSGD----------------------------------------------------------------------------------------------------------------------------------------------------------------KRRIRASQGHS--ID----------VDLQL------------------------------TPVTPP---DELYHGSATRFT-DAILATG--LQPGQRRHVHLSADV------------------------ETAHKVGSRHG-KPVIFRIDAKALTL-A------------GHAFYLSANQVWLTD-----------AVPPQYLSLLDTSPQ  179   Hahella chejuensis KCTC 2396                             bacteria>proteobacteria>gammaproteobacteria
    325189229  64   17    SKKLSYALRHG--ALD-LKLD--MTTD-GYVDTS--HL--LAKSMFA------------SYTISDIERVVETND-KKRYEMRRD--------------------------------------------------------------------------------------------------------------------------------------------------------------geGKFIRATQGHS--LK--------IVNDEHLL--ALVS-----------------------DANEI----EHCIHGTLEQNW-TQIENSG--LSSMKRNHIHFTTQEf-----------------------GAQVISGMKQT-SELMVYINIRQAMQ-H------------GIKFYRSSNNVLLTRGIND-----SGTLPVRYVDSGTLPVR  198   Albugo laibachii Nc14                                    eukaryota>stramenopiles
    254578506  68   9     SKSLSYLLRHG--ALK-EKLP--IDAN-GYVPLQ--VL--LAHNRLK----------SHRCTLEDVHRIVDSNE-KKRFHTKVSs-------------------------------------------------------------------------------------------------------------------------------------------------------------egQELICATQGHS--IK-------SVLPTEDVL--HEIR-----------------------DPKELP---PKLVHGTTVHNA-LLILQSG-AIKKLRRNHVHLSPGVtgv---------------------DAAVVSGMRAT-SNVHIYIKLGSELL-E------------QMKVYKSLNNVYLVP----------DDVPIALFDPDDVPIA  194   Zygosaccharomyces rouxii CBS 732                         eukaryota>fungi>ascomycota
    45198857   69   14    SKSLSYLLRHG--ALK-EQLP--IDSD-GYVPVS--AV--LAHNRLK----------SHRCSFSDLQRIVENNE-KKRFHMRPGp-------------------------------------------------------------------------------------------------------------------------------------------------------------dgQEYICATQGHT--IE-------QVLPSADVL--TQLI-----------------------DPGELP---AQLIHGTNLRNA-VLILDSG-CIKRMQRNHVHLSHGVtg----------------------KDCVISGMRLS-STVHIYLNTE-GIL-D------------HLRLYKSRNDVYLTP----------SDIPVVYLTPSDIPVS  193   Ashbya gossypii ATCC 10895                               eukaryota>fungi>ascomycota
    255712699  71   11    SKSLAYLLRHG--ALK-EKLP--IDPN-GYIPIS--VL--LQHNRLK----------SLHCTQQDVDRVVANNA-KKRFHIKTE--------------------------------------------------------------------------------------------------------------------------------------------------------------dnNVLICATQGHS--IA-------AVAPAGDVL--QPIT-----------------------ADDKLP---EKLVHGTNLKNC-KLIIESG-GIRKMRRNHVHLAAGItgl---------------------DGEVVSGTRTS-SNVFIFLKRE-LAF-Q------------QLRLFKSLNDVYLTA----------DDVPTELFEADDVPTE  194   Lachancea thermotolerans CBS 6340                        eukaryota>fungi>ascomycota
    50305581   72   15    SKALAYLLRHG--AVK-ENLP--IDSD-GYIALD--RI--LQHNRLK----------SLKATSTEIQHIVASND-KQRFHIKTDpn------------------------------------------------------------------------------------------------------------------------------------------------------------tgIMYVCATQGHT--LK-------QIAPSQHVL--KPIT-----------------------NIEQLS---SKLVHGTNVSNC-ISILHSG-FIKKMSRNHVHLSPGItgk---------------------DTDVISGMRSS-SNVYIHIKRIQEML-D------------SLNLVKSLNNVYLTS----------QDIPLKFIDFQDIPLK  204   Kluyveromyces lactis NRRL Y-1140                         eukaryota>fungi>ascomycota
    151945531  75   15    SKALSYLLRHA--AVK-EKLT--IDSN-GYTPLK--EL--LSHNRLK----------THKCTVDDIHRIVKEND-KQRFHIKTLga-------------------------------------------------------------------------------------------------------------------------------------------------------------dEEWICATQGHS--IK-------SIQPSDEVL--VPIT-----------------------EASQLP---QELIHGTNLQSV-IKIIESG-AISPMSRNHVHLSPGMlh----------------------AKGVISGMRSS-SNVYIFIDCHSPLFFH------------TLKMFRSLNNVYLSS-----------SIPVELILSSSIPVE  198   Saccharomyces cerevisiae YJM789                          eukaryota>fungi>ascomycota
    126131670  84   1     SKAMSYLLRHA--AVK-EKLA--IDED-GYVQIE--DL--LKHQRLK----------TFRTSIADLERVVQNDN-KQRYTIK------------------------------------------------------------------------------------------------------------------------------------------------------------------DNAICANQGHS--IK---------SVGSDNL--ELLT------------------------LETIP---SEVYHGTYRNKL-GLIYSSG-GLNRLRRNHIHMTSK-------------------------AYSVKSGIRYN-ANVLIYIDVAKCME-A------------GIKFYKSLNDVILSEGDEN------GYISWKYFDKVVEVKT  188   Scheffersomyces stipitis CBS 6054                        eukaryota>fungi>ascomycota
    156845856  76   3     SKALSYLLRHG--AQK-EKLS--INSN-GYILVK--DI--LSHNRLK----------THKCTLEDLHRIVENND-KKRFHLKIV--------------------------------------------------------------------------------------------------------------------------------------------------------------ddQEHICATQGHS--LK-------TVKPSDEVL--EPVL-----------------------SLDQLP---KRLVHGTNLQNA-ILIFKSG-QIKKMNRNHVHLSPGVige---------------------DSEVVSGMRYS-SNVHIFLKLNDSLL-E------------NLKLFKSINSVYLSA----------VDIPTDLVEAVDIPTD  201   Vanderwaltozyma polyspora DSM 70294                      eukaryota>fungi>ascomycota
    241952517  83   14    SKALSYLLRHG--AEK-EKLS--IDEQ-GYVKIS--DV--LSHQRLK----------SLKTTIEDIERIVREND-KKRFTIR------------------------------------------------------------------------------------------------------------------------------------------------------------------DEMICANQGHS--LK---------AVKNDNL--VPMT-----------------------IDELNQ---LRIYHGTYKTKL-PIIKSSG-GLSRMNRNHIHLTCD-------------------------QYATCSGIRYN-ANVLVYIDASKCIE-H------------GIVFYKSLNNVILTSGDKD------GKISWEFIDRIVDLEG  192   Candida dubliniensis CD36                                eukaryota>fungi>ascomycota
    260945038  87   36    SKALSYLLRHG--ADK-EKLP--LDEH-GWAKVS--DV--LANNRIR----------THRATQEDIRRIVAQNA-KQRFTLRER--------------------------------------------------------------------------------------------------------------------------------------------------------------sdGDYICANQGHS--LE---------RVCPEL---ELLT------------------------SETMP---REVYHGTYENKL-DTIMQHG--LNRMARNHIHLACN-------------------------EPWSRSGSRAS-STVFIYIDIDKCLS-A------------GISFYRSKNGVILTSGNAQ------GCIPSEYFAQGCIPSE  214   Clavispora lusitaniae ATCC 42720                         eukaryota>fungi>ascomycota
    255638634  99   101   SRLLTRILRHM--ASE-LNLN--MRSD-GYVKVN--DL--LKLNLKT-----fanipLRSHTIDHIREAVRKDN-KQRFSLLEE--------------------------------------------------------------------------------------------------------------------------------------------------------------ngELLIRANQGHT--VK--------VVETESLL--KPIL-----------------------SAKEFP----VCLHGTYRKNL-ESILGSG--LKRMKRLHVHFSCGLpt----------------------DGEVISGMRQD-VNVLIFLDVRKALE-E------------SIKLYISDNKVILTEGFD-------GVVPPKYFEDGVVPPK  289   Glycine max                                              eukaryota>viridiplantae
    148907021  100  374   -RSLSSVLRHR--ADE-LKLN--IRSD-GYVAVK--DL--LKLNVKT-----parvpLNSHSIDDIKEAVKRDN-KQRFGLLEE--------------------------------------------------------------------------------------------------------------------------------------------------------------ksVLLIRANQGHS--IN--------FIDSEELL--KPIL-----------------------SAEDVP----VCVHGTYLKNL-ELIKKNG--LNRMKRNHVHFARGLsk----------------------DSGVISGMRSD-CEVFIYLDTKKALQ-G------------GMKLFVSENGVILTEGFN-------GVVPPEYFFNGVVPPE  560   Picea sitchensis                                         eukaryota>viridiplantae
    168049051  102  9     -RCMTAILRHR--ASD-YGLE--MQND-GFVLVA--DL--LKLSKNT-----aagipLSSHSVEDVRKAVARDG-KRRFGLKEE--------------------------------------------------------------------------------------------------------------------------------------------------------------dgHLYIRANQGHS--IR--------TVESGQLL--SLVT-----------------------SPSQIP----VCVHGTYERFM-DSIWQEG--LKRMNRNHVHFATGLpe----------------------QDGVISGMRGS-AQVLIYLDVEKAME-D------------GMKLYVSDNKVVLTEGFD-------GVVPTKYFFDGVVPTK  195   Physcomitrella patens subsp. patens                      eukaryota>viridiplantae
    302766619  103  36    -RALTKILRHR--AAE-LNLE--MRSD-GFCKVA--DL--LRLDFTT-----rskvpLSAHTVEEVLQAVEQNS-KERLATMVDe-------------------------------------------------------------------------------------------------------------------------------------------------------------sgELLIRANQGHT--LL-------DAVCSDDLL--EEIS-----------------------IDDNML---AVCVHGTFKHAL-PGILRDG--LKTMGRKHVHFAAGLpg----------------------AGEVVSGMRGS-CDALVFVNAARAMA-D------------GMKFYVSKNGVVLTEGFE-------QCVPAKYFDEQCVPAK  226   Selaginella moellendorffii                               eukaryota>viridiplantae
    302756333  104  15    -RAMTKILRHE--AAT-FNLD--LRSD-GYCKVD--EL--LKIGMKT-----ragipLSSHSVEEVLQAVKQDN-KQRFSTTRE--------------------------------------------------------------------------------------------------------------------------------------------------------------dgTLYIRANQGHS--IK--------EVLSDHLL--REIS-----------------------STDKIP----VCIHGTYKHAL-PSILESG--LKVMGRNHVHFATGLpd----------------------ENGVISGMRSS-CQVLIYLDTEKAMA-D------------GMKFYVSDNNVVLTEGFE-------GCVPCEYFEEGCVPCE  202   Selaginella moellendorffii                               eukaryota>viridiplantae
    302757341  106  13    ---LCRILRHQ--ATQ-LSLP--IRSN-GYVKVD--DI--LRLTIRT-----hagipMNEHSVEEVLRVVERDP-KQRYSTMVE--------------------------------------------------------------------------------------------------------------------------------------------------------------ggELFIRANQGHS--MK--------VVASDALL--TEIT-----------------------SADQVP----VCVHGTFRCFL-PSIMRTG--LNRMSRNHVHFAIGLpn----------------------EEGVISGMMDS-VEVLIYLNVAKALQ-D------------DMKLYISDNKVLLTEGFA-------GVVPCEYFEAGVVPCE  198   Selaginella moellendorffii                               eukaryota>viridiplantae
    302796097  107  2     SKTIAWVLRHG--AVK-MDLK--IRSN-GYCSIK--DL--LEMDVKI-----gggipLSSFTVADVMSMVACDP-KQRFSTIEEe-------------------------------------------------------------------------------------------------------------------------------------------------------------ddQLYIRANQGHT--MD--------AVQTAELL--REIK-----------------------SADEVP----MCVHGTFRNNF-RGIRKTG--LKRMKRNHVHFATGLp-----------------------QDGVISGMKSK-CEVLIYLDLAKAMK-D------------GMKFFMSENGVVLTEGFD-------GVVPREYFEDGVVPRE  195   Selaginella moellendorffii                               eukaryota>viridiplantae
    302782377  108  2     ------ILRHQ--AVE-MGLK--IRSD-GYCRMN--DL--LKLQPMR------------GHSIQDVLKVVETDL-KTRFSTNVE--------------------------------------------------------------------------------------------------------------------------------------------------------------ngILFIRANQGHS--MK--------AVVTEKLL--KEIE-----------------------SADQVPGTSKVCVHGTFKKNL-ASIRRTG--LCVMGRNHVHFATGLpr----------------------DDGVVSGMRNT-CDALIFLDVEKALD-D------------GMQLFISENRVVLTEGFG-------GVVPPRYGFGGVVPPR  179   Selaginella moellendorffii                               eukaryota>viridiplantae
    290988948  114  32    SRALSKLLRHK--ADKTKGIN--LRAD-GYVLIR--EI--LALKDFK------------GVTQQMIEECVKNND-KQRFNMTQDat------------------------------------------------------------------------------------------------------------------------------------------------------------tgEYIIRANQGHT--IA-------VEVEMEEI---DSPS-----------------------KLGEYA---NTVMHGTYHDAY-DKIVQSG-GLSRMSRQHIHFAIGEpe----------------------EGHVISGMRKS-AEVCFFLDVQKTID-E------------GIKLLKSSNGVILSLKSSN------GVILSPGNDKGLIPMH  210   Naegleria gruberi strain NEG-M                           eukaryota>heterolobosea
    322505025  115  365   SKFMSALLRHK--AVQ-WRVP--ITSN-GYVLLD--DV--LRQPQMR---------rKPQVSVQDVARMVRDSD-KQRFQLAYGaa------------------------------------------------------------------------------------------------------------------------------------------------------------dgRLYITATQGHS--ID---------GVEPKL---RTLT-----------------------SVEEVP----MAIHGTYWEAW-KTIQRCG-YLSAMTRQHIHFAKGLmn----------------------DAQVISGMRNN-VQLFIYLDVAAVLA-D------------GVALYESTNGVILTPGVG-----DTRQLPLKYVDTRQLPLK  560   Leishmania braziliensis MHOM/BR/75/M2904                 eukaryota>euglenozoa>kinetoplastida
    261334507  116  333   SKALSRILRHG--ADK-MKIT--ISDA-GYVLAD--DL--VRCAPFS----------NDKAALTHLAWVVYSND-KKRFKMAYDe-------------------------------------------------------------------------------------------------------------------------------------------------------------nrRVYIRANQGHS--LS---------GINPEL---VPIT-----------------------SETQVP----FAVHGTYYSAW-ERIRGCG-YLSTMGRQHIHFAKGMpg----------------------SDGVISGMRNT-SEVLLVLDVPLLLK-E------------SVELWESANGVLLTRGVS-----GTGRLPLKYIGTGRLPLK  526   Trypanosoma brucei gambiense DAL972                      eukaryota>euglenozoa>kinetoplastida
    322815443  117  372   SKTLTRILRHA--ADK-MGIP--VSSG-GFVHVD--HI--LRCKPFC----------NDPLALSHIALVVHTND-KKRFKMAYDd-------------------------------------------------------------------------------------------------------------------------------------------------------------qhRLYIRANQGHS--LA---------GIDPEL---RRIE-----------------------SATEMP----AAIHGTYYSAW-KEICACG-YLSTMTRQHIHFSRGLis----------------------DHCVISGMRSN-VEVLLYLDVAKVLA-D------------GIELWESENGVLLTPGMG-----STKRLPLTYISTKRLPLT  564   Trypanosoma cruzi                                        eukaryota>euglenozoa>kinetoplastida
    328867666  123  5     SKAMSYILRHG--CAK-ERIE--ISAD-GYVKVN--DL--LKNKNFK------------NITFQDIQHVVDTND-KKRFELKQQ--------------------------------------------------------------------------------------------------------------------------------------------------------------dnEYYIRASQGHT--IK--------TVTENDSLF-TKIT-----------------------DINQVP----GVIHGTYRKHL-VSIKEKG--LNKMDRNHIHFATGD------------------------HGDVVSGMRGN-CEIVIYIDLEKALN-D------------GIEFLLSKNGVVLCAGIQ------ TEHVLCAGIQTEHGNHY 188   Dictyostelium fasciculatum                               eukaryota>amoebozoa>mycetozoa>dictyosteliida
    281203700  124  9     SKTLSYLLRHG--AVK-EGLT--ISND-GFVKVN--DV--LNHKQMR------------GVTLEKLREIVDTND-KKRYHLEEI--------------------------------------------------------------------------------------------------------------------------------------------------------------ggVLNIRANQGHT--LK--------HVDDVDL---KKIE-----------------------SVNDVP----SVIHGTYRKHL-ESIKSKG--LNKMDRNHIHFATGD------------------------HGDVVSGMRGN-CELVIHINLQKALD-D------------GIPFFLSKNGVVLCAGDKN------GYLLCAGDKNGYLSPI  182   Polysphondylium pallidum PN500                           eukaryota>amoebozoa>mycetozoa>dictyosteliida
    330795375  126  10    SKTLSYILRHS--AVK-EGLN--ISKD-GYVSVD--EL--LKHKLFS------------QYTFKDIQEVVDTND-KKRYNLKKGege----------------------------------------------------------------------------------------------------------------------------------------------------------nseKYFICANQGHS--IS--------DVDEVDL---KRIE-----------------------SVDEVE----SVVHGTYKKHL-KSILENG--LQKMERNHIHFAVGLpg----------------------EGQVISGMRGS-CDMVIYIDLQKCLD-D------------DIPMFLSKNNVVLTNGKDNN-----GILPIKYDNNGILPIK  202   Dictyostelium purpureum                                  eukaryota>amoebozoa>mycetozoa>dictyosteliida
    238496189  147  18    SKALSLLLRHA--AEK-EGLK--LDAQ-GYANVA--DV--LAWRKLK----------SLKVTFPEIVAAVATSD-KKRFALLHIpst----------------------------------eaqa-------------qqstsaeastehgipttsagqdsatetalavsesd-------------------------------------------------------------------ldpaHFLIRATQGHS--IK---------SVDAASLMEKLSL----------------------dEEAKLP---DTVVHGTFHAAW-PAILASG-GLKSMGRNQVHFATGPsvesvlaqgaqgskevtgdh----GEKVISGMRRD-AQVLIYIDLKKALA-A------------GCPFWRSENGVILSEGMVVE--GSSGIVPVEFFDSGIVPVE  272   Aspergillus flavus NRRL3357                              eukaryota>fungi>ascomycota
    149246000  82   23    SKALSYLLRHG--AEK-ENLA--IDNL-GYVPIV--QI--LQHQRLK----------SFKTTREDIERIVAEND-KQRFSINAE----------------------------------------------------------------------------------------------------------------------------------------------------------------EDTICANQGHS--LS---------SVSGTL---DLLT-----------------------KAQLAE---MAIYHGTYKKKL-PLILGSG-GLSRMNRNHIHFTCE-------------------------QYHTISGIRNS-ANCLIYIDTDKCID-Ey-----------GLQFFKSANNVILCAGNEHGVIPVDCFAKVVDLKGQPVKVV  189   Lodderomyces elongisporus NRRL YB-4239                   eukaryota>fungi>ascomycota
    254573246  80   8     SKALSWLLRHG--AQS-EKLT--IDKD-GFVPLE--EV--LNHRRIK----------GTRASFEDVQRIVDNND-KKRFTLQKR--------------------------------------------------------------------------------------------------------------------------------------------------------------ddRWFICANQGHS--IA---------NVNGHDL--KLLS-----------------------TREDLP---KEIIHGTYLSKI-PQIIASG-GLSKMTRNHVHFASGLpkv---------------------DSDVISGMRNG-CSALIYLDIDKILG-Qq-----------EIKFYISKNKVILSYISKNKVILSPGNKDGIVPTSLFLKVV  181   Pichia pastoris GS115                                    eukaryota>fungi>ascomycota
    294657248  81   14    SKSLSYLLRHG--AVK-EKLN--IDQT-GYININ--EL--LNHNRLK----------TNKVTLDDIRRIVGNND-KKRFSIVEK--------------------------------------------------------------------------------------------------------------------------------------------------------------egEIMICANQGHS--IK---------TVNDSNL--IQLS------------------------KDTIP---EEIYHGTYKNKL-PAIFNSG-GLSKMNRNHIHFASSI--------------------------SDVSGIRNS-SNVLIYLNIEKCLQ-S------------GIVFYRSSNNVILTYRSSNNVILTSGDANGLIGSEFFGKVV  180   Debaryomyces hansenii CBS767                             eukaryota>fungi>ascomycota
    50290283   67   10    SKALSYLLRHG--AVK-ENLP--FDVN-GYIEVE--RV--LNHQRLK----------SHKCTLEDLHRVVDTND-KKRFNIKLS------------------------------------------------------------------------------------------------------------------------------------------------------------ddgqTELICAVQGHS--ID-------RIKPDEEVL--EVID-----------------------TAEKLP---KNIIHGTSVRNA-IQILKSG-SIKRMNRNHIHLSIGItek---------------------DKEVISGMRKS-SRVHIYILSEPKIL-E------------HLKLYRSMNSVILTYRSMNSVILTPDDINKSLFLLVKIRAA  186   Candida glabrata CBS 138                                 eukaryota>fungi>ascomycota
    146417847  90   8     SKALSYFLRHG--AQK-SNLE--IDDR-GFIKVA--DL--LAHQNLK----------SKKTTLQDILRVVETNE-KKRFALEDR--------------------------------------------------------------------------------------------------------------------------------------------------------------ngELYICATQGHL--IH---------TVTEGNL--RPL------------------------DEASLP---KQIIHGTRKRAL-EQIRKSG-GLSKMGRNHIHCTSDH--------------------------NLVSGFRST-SDTLIYIDGVQCLR-D------------GIKFFQSSNGVILSFQSSNGVILSPGNDQGVIECKYFAKVT  174   Meyerozyma guilliermondii ATCC 6260                      eukaryota>fungi>ascomycota
    328769603  94   6     SKALSYLLRHG--AEK-ERLV--IESD-GFVKLK--DI--LSRKQFS------------GQTLESIQHLVESNA-KQRFALRQDpt------------------------------------------------------------------------------------------------------------------------------------------------------------tlQWSIRANQGHS--IN----------VNVEM---RTVQ-----------------------DSSEIP----LVVHGTYQQHL-ALILKQG--LRSMSRKHIHFAAGLpe----------------------HQDITSGMRNN-CNILIYVNTEKAMK-D------------GIVFVQSANNVILTEGVANNVILTEGVDGVLHPRYFSKITD  184   Batrachochytrium dendrobatidis JAM81                     eukaryota>fungi>chytridiomycota
    167377905  95   11    SKRLSYLLRHG--AIK-ERIP--ITKD-GWVLIK--DL--LNNRQMK------------GISEEEIKSIVAKDP-KKRYSIQGE--------------------------------------------------------------------------------------------------------------------------------------------------------------gnQIKIRANQGHS--IN----------VQVEM---KEIT-----------------------DASLYP----IVIHGTYMRNF-NSIIKNG--LQKMGRLHIHMAQGLpke---------------------IKEEKSGMRSS-CNIIIYIDIEKAMK-K------------GIKFYESENGVILSEGPIDISCFSEGPIDIS----------  186   Entamoeba dispar SAW760                                  eukaryota>amoebozoa>entamoebidae
    242785264  145  17    SKALSHLLRHS--AEK-ENLK--ISKE-GYVNVA--DL--LETRKVK----------SLKVTLPEIIQAVASSD-KQRFSLFYIspa----------------------------------tiesg------------nqesqeqqeavvataaseekqknatahalsvkd---------------------------------------------------------------------ndpsHFLIRATQGHS--MK---------SVDTTLFLEKLSL----------------ddtkedgAASNLP---DTVVHGTYHGAW-PLILASG-GLRSMSRLQVHFATGPtmdevypngrdapialldprs---KATVISGMRSD-AEILIYINLRRALE-A------------GCPFYRSENGVILSEGMNLGDSGEGKIVPIEFFDLKIVPIE  280   Talaromyces stipitatus ATCC 10500                        eukaryota>fungi>ascomycota
    119498195  146  20    SKALSLLLRHA--AEK-EGLK--MDSQ-GYANVA--DV--LAWKKLK----------SLKVTLPEIIHAVASSD-KKRFALLHIpsa----------------------------------kalgdktttgaregetpvcetepssmptsqvpttsagqenatatalavnd---------------------------------------------------------------------tdpsHFLIRATQGHS--IK---------SVDAAAFLERLTL----------------------eDESRLP---DTVVHGTYHAVW-PAILQSG-GLRCMGRNQVHFATGPslesvlpahvdgtahsamgssglnDGRVISGMRRD-AQILIYIDIKKAMA-A------------GCPFWRSENGVILSEGVDVGVILSEGVDVGENQEVGDGTSQ  276   Neosartorya fischeri NRRL 181                            eukaryota>fungi>ascomycota
    225682414  150  26    SKALSYILRHA--AEK-EGVK--IDSH-GYANVA--DV--LAWRKLK----------SLKVTLPEILSAVSTSD-KQRFGLLYEpls----------------------------------nspsatai----------ptdcsa----------stasrtataqaltand---------------------------------------------------------------------pepsHYLIRATQGHS--IK---------TVEASSLLQRLSLt---------------dgadaapSTPPLP---DTVVHGTYHGAW-PSILVSG-GLKCMNRNHVHFATGPplssvlpegreghvvtmapg----RGGVISGMRAD-AQILIYIDLKKALE-A------------GVPFWRSENGVILSEGLDMDVILSEGLDMDGDGRKIVGLEF  266   Paracoccidioides brasiliensis Pb03                       eukaryota>fungi>ascomycota
    296825168  154  19    SRELTFILRHA--AEK-EGIK--IDRQ-GYANVG--EL--LQYRKLK----------GLKATLADVLEAVSTSD-KQRFGLLYIpdq----------------------------------pslpeinake------------------eaatgdesslltatnqalaand---------------------------------------------------------------------pdpnNYLIRARQGHS--MK---------CIDSASLLTPLTLs--------------------enPSVPLP---ETVVHGTYHATW-PKILQSG-GLRCMGRNHIHFASGPpissvlpngrggevatppakshg-RDSVISGMRAD-AQILIYIDLKRALA-A------------GCPFGISENGVILSEGIENGVILSEGISSDGTDDKKIGLEF  262   Arthroderma otae CBS 113480                              eukaryota>fungi>ascomycota
    66807493   127  19    SKSLSYVLRHG--AEK-EGLK--IDSQ-GFIKVD--DI--LKNNLFK------------NTNFKEIQEVVDTND-KKRYHMELNds------------------------------------------------------------------------------------------------------------------------------------------------------------dgCYYIRANQGHT--LE--------NVDNVEM---TKIT-----------------------SADQVG----TVFHGTYRKHL-QSILNEG--LKKMDRNHIHCVNKIm-----------------------GQEITSGMRGS-CNMIVYIDVPLLLQ-D------------GIDLYLSQNNVALTDGLQNNVALTDGLNNTGILPPKYFIKI  190   Dictyostelium discoideum AX4                             eukaryota>amoebozoa>mycetozoa>dictyosteliida
    50547707   131  15    SRKLSYILRHG--ATK-EKLP--IRED-GYLSVG--VL--LNRAGIK-----------GKWNLEDTKRVVRDND-KQRYKLIFEptd------------------------------------p--------------------------------------------------------------------------------------------------------------------ndctGYWIRANQGHT--IN----------TKVEM---KALK-----------------------TPEDFPT--LEIFHATSKQVL-PIVLKEG--LSKMKRQHIHLATDLvt----------------------EGGSVAGKRLN-REVFIYINVPKALE-A------------GIEFFLSENGVVLTELSENGVVLTEGKDGKISREFFSKILD  198   Yarrowia lipolytica CLIB122                              eukaryota>fungi>ascomycota
    170105752  133  5     SKTLSYLLRHG--AQG-EGLP--MRKD-GYVKVA--DL--LQNPKLK----------TQGLDLDKIRDIVGKDS-KQRYDLISDst-----------------------------------------------------------------------------------------------------------------------------------------------------------dpnVWWIRARQGHS--LK---------TVELDL---KPIL-----------------------SATDIST--GVAVHGTTLAAW-ESISKQG--LSKMKRNHIHLAQGLpg----------------------HNGVISGMRSS-SQIFIYINIQAALS-S------------GIQFFFSDNGVVLTFFSDNGVVLTAGDDKGFLKPEFFLRVE  178   Laccaria bicolor S238N-H82                               eukaryota>fungi>basidiomycota
    336366767  134  31    SKSLSWLLRHG--AQS-DGLV--LRSD-GYARVA--DV--LANPRFR------------GVTYPMLEDIVRQDR-KQRYNLLCEags----------------------------------leas-------------------------------------------------------------------------------------------------------------------sgsdVWWIRANQGHS--IK---------TIEIEL---NPIA-----------------------SATDIP----MAVHGTNRKAW-ELISTQG--LSKMKRNHIHLAQGIa-----------------------GDSVVSGMRKS-SQILIYIDVQKAID-A------------GIKFSLSSNGVVLTELSSNGVVLTEGDETGFLAPRFFQRVE  206   Serpula lacrymans var. lacrymans S7.3                    eukaryota>fungi>basidiomycota
    242218580  135  2     SKTLSWVLRHG--ARS-EGLE--MRPD-GYVRVD--DLVSLKIPKMR------------EMNFDMLEQIVKADN-KSRYNLIHEpdk----------------------------------avg--------------------------------------------------------------------------------------------------------------------spsqIWWIRANQGHS--MK---------TVVLDL---QPIQ-----------------------SPADIPT--GLAVHGTSRKAW-DIICEQG--LSKMSRNHIHLAQGVp-----------------------GSGVIS-MRSS-SSILIFVDIQKALA-A------------GIRFYLSDNGVVLTDLSDNGVVLTDGDEKGFLSPQFFARVE  179   Postia placenta Mad-698-R                                eukaryota>fungi>basidiomycota
    302686072  139  4     SKTLSYILRHG--AQK-EGIP--IRPD-GYVKVD--DL--LANNRLK----------SQAVTLEMIQQIVKDDV-KQRYDLVLEqp-------------------------------------------------------------------------------------------------------------------------------------------------------------sTWLIKANQGHS--LQ---------TVKLEL---KPIL-----------------------SRADIPT--GVTVHGTMNHAW-QSISKQG--LSKMKRNHIHLAQGKg-----------------------GKDVISGMRRS-SEVFIFVDVDRAIA-A------------GIKFELSDNGVVLTELSDNGVVLTEGDERGFLPVRFFQKVE  175   Schizophyllum commune H4-8                               eukaryota>fungi>basidiomycota
    296416279  156  69    SKALSYTLRHG--AVK-EGLA--LQDD-GYANVG--EL--LQLPKFR----------KMSLTFEKLRQVVSEND-KQRFSLTPTaa------------------------------------------------------------------------tatatepaataed-----------------------------------------------------------------------phTYLIRATQGHS--LP---------LTNTSTLLTPL--------------------------PPNI----TCAVHGTFYPAY-EAILACG-YLSRMGRTHIHLATG-------------------------EIGVKSGMRAD-AQVLFYVDVGRARR-Eg-----------GVEFWISENGVVLTWISENGVVLTAGDELGRLGLEFVERVV  257   Tuber melanosporum Mel28                                 eukaryota>fungi>ascomycota
    154295249  158  4     SKALSKLLRHA--AES-EGVE--LDGE-GFARLD--LV--MQWPRLK----------SLKPTFADIRTAVTDNA-KQRFSMKPNps----------------------------------------------------------------------------lpeapspss---------------------------------------------------------------------enpaDWMIRANQGHS--IV----------IDSAALLIPITL-----------------------EAENVP---ETCAHGTYFAFY-EEILRSG-GLKKMGRTHVHFVTGIpe----------------------DGGLVSGMRGD-AELLIFVDVKRCLE-Eqp----------EMKWWISENRVVLTEGSENRVVLTEGDGEGVVGTRFWKRVE  193   Botryotinia fuckeliana B05.10                            eukaryota>fungi>ascomycota
    302916847  159  52    SKALSKLLRHQ--AGN-AGIQ--LDDE-GFAPLS--SV--LAWGPLR----------SLKVTLDDVQSIVTSND-KQRFTLKPNps----------------------------------------------------------------------------tnpslstts---------------------------------------------------------------------tspeDYLIRANQGHS--IK----------LESAALLAPITI-----------------------EAGNVP---DRVLHGTFFYFW-PKIVETG-GLKPMNRNHVHCSTGTp-----------------------EEGVVSGMRKD-AELVIEIDIEASLK-E------------GVKWWMSDNGVLLTEMSDNGVLLTEGDEQGILSSKFFKLAT  237   Nectria haematococca mpVI 77-13-4                        eukaryota>fungi>ascomycota
    322707126  160  40    SKALSRLLRHQ--AEN-AGIK--LDEE-GFAPLD--R---LSWGPIK----------SLSPSLQEVKDVVETNA-KKRFTLRPAdp--------------------------------------------------------------------------------lapep---------------------------------------------------------------------psaaGYLIRANQGHS--LK----------VDEAALFEPILL-----------------------GAADLP---GKVVHGTYFAFW-KAILESG-GLKPMSRGHIHCSDRTp-----------------------EEGAVSGMRRD-AELLVEIDIEASLK-D------------GVTWWRSDNGVILTDRSDNGVILTDGGEGGVLETKYFKMVT  220   Metarhizium anisopliae ARSEF 23                          eukaryota>fungi>ascomycota
    213408531  178  9     SRALSKVLRHT--ARS-CGLK--LTEE-GYARVD--DL--LKLPQFK------------GLTVDVLQQIVADND-KQRFALSTIn--------------------------------------------------------------------------------------------------------------------------------------------------------------dELHIRANQGHS--LT----------TVHVDMP-RIT------------------------DPAEIP----RVVHGTFAKFW-PAIYANG--LSRMKRQHIHCAKGLfg----------------------EPGVVSGIRKS-CDVFIFIDAARAMA-D------------GVVFYRSENGVILTEGIENGVILTEGIDGVLPRKFFLRVEN  180   Schizosaccharomyces japonicus yFS275                     eukaryota>fungi>ascomycota
    310792989  170  37    SKALSKLLRHQ--AEN-AGLK--LDEG-GYAPLD--KV--LAYGPIR----------SLQVSFADIQAAVTTSD-KQRFALKPNav----------------------------------------------------------------------------tnpsldeks---------------------------------------------------------------------tepsHWLIRANQGHS--IK----------VDSAGLLTPITL-----------------------DAGNVP---EVVVHGTYFAFW-RAIEESG-GLARMGRNHVHFATGLpgd---------------------EQGVVSGMRRD-AEVLVYVDVERALR-Eee----------GMRWWVSENGVVLTEGSENGVVLTEGDEEGRVPTRLFREVR  227   Glomerella graminicola M1.001                            eukaryota>fungi>ascomycota
    19115427   179  38    SKALSKVLRHT--AKA-NGLQ--IRED-GYIEVD--SI--LKLPQFR------------GMGMELLLSIVKGND-KKRFTMEEVe--------------------------------------------------------------------------------------------------------------------------------------------------------------gVLYIRANQGHS--IK----------AVQVPMA-RI------------------------dNASSIP----KVVHGTKKELW-PVISKQG--LSRMKRNHIHCATGLyg----------------------DPGVISGIRKS-CTLYIYIDSAKAMQ-D------------GVEFYRSENGVILTEGVENGVILTEGVNGLLSSKYFSRVET  207   Schizosaccharomyces pombe 972h-                          eukaryota>fungi>ascomycota
    326431934  185  660   SKYLSYVLRHG--AQK-EGVS--MAPD-GSVALE--DL--LRRPQLK------------GLSSKEIKHIVETCP-KQRFVLLPGt------------------------------------------------------------------------------------------------------------------------------------------------------------gptGLRIRAAQGHT--IK---------VADESQLLTAIT------------------------DASKFP----VVVHGTYAKLV-PVIKREG--LSRMRRRHIHFATGLpg----------------------DQEVKSGMRKS-CTAFVYIDLAKCLR-D------------GIPFFVSSNNVVLSFVSSNNVVLSPGLGSTGILPPQYFTNV  832   Salpingoeca sp. ATCC 50818                               eukaryota>choanoflagellida
    303284891  186  69    ---LSQLLRHG--ALD-AGLGDVLTPA-GGVPLD--RV--LALPRFK------------GVTAEAIETLVANCP-KRRFELFLAek------------------ggggd------------------------------------------------------------------------------------------------------------------------------------dvtTKMIRATQGHS--IRg-------GALDDDAMLARVSV---------------------erARAELR----YAVHGTSLRAW-ETIKTEG--LLRMRRRHVHLAAALpgs---------------------ADEVTSGMRSD-AQVAVWVDVAAAVA-D------------GVAFFVAANGAVLTPGVANGAVLTPGVGRDGVLHPRYFHRA  253   Micromonas pusilla CCMP1545                              eukaryota>viridiplantae>chlorophyta
    255086119  187  3     SKNLSQILRHG--VVD-EGLADCLDAE-GFVPLA--RV--LALPRFR------------GVGADEIRALVAADR-KGRFELRDRt-------------------------------------------------------------------------------------------------------------------------------------------------------------dgIVHVRATQGHT--LRg-------DVLDDDAMATRLT------------------------RTSGIR----EAVHGTSMRAW-KRIRTHG--LSRMRRRHVHMATGLpg----------------------DGEVKSGVRND-CEVAVWVDVERGVA-E------------GVPFFVSANGVVLSFVSANGVVLSPG---------------  176   Micromonas sp. RCC299                                    eukaryota>viridiplantae>chlorophyta
    167518371  190  1     ---MTYLLRHG--AEK-EGVP--MSKD-GFVHTA--DL--RRHDKLR------------HLDDDTVREIVATDA-KGRFELRE----------------------------------------------------------------------------------------------------------------------------------------------------------------gPLRVRATQGHS--LN---------VQEDSLL-DPVL------------------------SAADWP----VVVHGTYHAAW-AQIQREG--LRTMGRQHIHFSTAEpg----------------------SREVISGMRTT-CNVWIYLDLDQVLR-D------------GIPVFISRNRVLLTFISRNRVLLTAGQDGVLHPRYFKRVVR  163   Monosiga brevicollis MX1                                 eukaryota>choanoflagellida
    145493555  191  14    SKAMSYLLRHG--AQK-EGIP--IRQD-GFVLVQ--DL--LNWKSMA----------NLKANVQSIRNVVDNND-KKRFELKEId--------------------------------------------------------------------------------------------------------------------------------------------------------------gQLYIRCVQGHT--IE---------INEEELL----------------------------gENTQFP----VIVHGTYFQAW-ELIKNTG--LNRMARQHIHFAVGLpg----------------------NDAVISGMRNT-CEVIIEVDMERAMK-A------------GIEFYVSKNGVVLSSGIKNGVVLSSGIDGVIAPQFFKRVTT  187   Paramecium tetraurelia strain d4-2                       eukaryota>alveolata>ciliophora
    118362535  192  19    SKKLAWLLRHG--AEK-EGLN--MGSD-GYVLLQ--EI--MSRNDFS------------TITFDKVKSVVDNND-KKRFEMIQKeh----------------------------------------------------------------------------------------------------------------------------------------------------------ngkiEWFIRASQGHT--IS--------SINDEELL-DKISL----------------------dVASSLG----IVVHGTYKQFW-EPISKEG--LKTMQRNHIHFAIGYpg----------------------DKEVISGMRKT-CDVYIEIDLVKAIN-D------------GIDFFMSKNNVVLTSGIKNNVVLTSGINKVLPPKYFKVVKD  196   Tetrahymena thermophila                                  eukaryota>alveolata>ciliophora
    322802863  196  9     SKRLSYLLRHG--AVK-EGLN--IKPN-GFITVE--DL--LNK-SLL------------QYTIDDIKRVVKTNN-KQRFTLATId--------------------------------------------------------------------------------------------------------------------------------------------------------------gILKIKANQGHS--IP--------TINQLSL---RIL------------------------EFIDF-----DIIHGTYLKYW-PKIKTEG--LSRMKRNHIHFAKGL--------------------------NFINGLRQS-ADLFIYVNFDKAKE-D------------GLIFLESENGIVLCAGNENGIVLCAGNSKGFIETRYFLKVI  178   Solenopsis invicta                                       eukaryota>metazoa>hexapoda
    156543836  197  47    SKKLSYLLRHA--AVK-KGFN--IRPD-GFIPVQ--EI--LKETP--------------GCTVKDIERVVANND-KQRFTLSSFd--------------------------------------------------------------------------------------------------------------------------------------------------------------nVLMIKANQGHT--IS--------QVDSLNL---KLL------------------------DSVDF-----DIVHGTYHSCY-EKIRHQG--LSRMKRNHIHFAKGL--------------------------NFINGLRRN-AELFIFINYPKAKG-D------------GLKFYKSENNVILCYKSENNVILCPGNSEGFVKTKYFLKSY  209   Nasonia vitripennis                                      eukaryota>metazoa>hexapoda
    328862875  199  5     SKTLSYLLRHG--AAK-EGLK--MRSD-GFVKIN--DL--LARPKLK------------GVELGDIERIVGKDS-KQRYAMIREpp------------------pdgssss-----------------------------------------------------------------------------------------------------------------------------------edIVYIRANQGHS--IQ---------VPELDL---VPII-----------------------DPEDIP----TVVHGTYMKFW-DTILLEG--LKPMKRTHIHFASGLid----------------------QPGVISGMRAS-REIDIYLDVTKCIS-A------------GILFHRSKNGVILSQGLPNGVILSQGLPDSNSIPSTYFQKV  193   Melampsora larici-populina 98AG31                        eukaryota>fungi>basidiomycota
    331216956  200  54    SKTLSYILRHG--ALK-ERLV--IRAD-GCIRLD--DL--LKRPKLK------------NYTIDDVRRVVAENE-KQRFALVDEqa------------------adgs---------------------------------------------------------------------------------------------------------------------------------------iVNYIRANQGHS--IK--------EVDQPDL---TPLI-----------------------DPIELP----TVVHGTYSKFW-DSIAQDG--LKPMSRTHIHFAKGLlg----------------------EEGVISGMRAS-CDTFIYLDVEKCLQ-A------------QIEFFLSSNGVILSEGLPAGVILSEGLPASKSIPAQYFKKV  231   Puccinia graminis f. sp. tritici CRL 75-36-700-3         eukaryota>fungi>basidiomycota
    260781042  203  22    SKSLSYLLRHG--AAK-MGFQ--LDPG-GFLYVD--EV--LKHPQFK------------RYTADDVRQVVADND-KKRFALQEEeg------------------------------------------------------------------------------------------------------------------------------------------------------------tgRLQIRANQGHT--LE---------VEELDL---TPIT-----------------------DPAEAP----TVVHGTFLSCW-DKIRTQG--LSRMRRNHIHFAPGEpg----------------------EDGVISGMRRT-CQVLVFIDMEAAMR-D------------GLQFFRSANNVILSFRSANNVILSPGNEEGLIPPKYFQQVL  192   Branchiostoma floridae                                   eukaryota>metazoa
    72010085   204  6     SKLLSLVLRHR--AQQ-LGFN--IYPG-GYVLVK--DL--LAHKMFK------------RFTEADIRRVVASND-KQRFSFKTNee------------------------------------------------------------------------------------------------------------------------------------------------------------tgELMICANQGHS--FD---------VPEPEL---EPIT-----------------------DASRFR----TVVHGTYFRHW-DQIRRQG--LKRMNRTHIHFAQGVpg----------------------ADGVISGMRRS-CQVMIFIDLPAALR-G------------GVKFFLSKNGVVLSFLSKNGVVLSPGDKDGILRTRYFSSVM  174   Strongylocentrotus purpuratus                            eukaryota>metazoa>echinodermata
    221487185  210  907   IKKLNFILRHGAPLFK---LP--MRED-GYVRIR--EL--LELDCMR------------SVSWEEIYLVVASNF-KRRYEICYDptepehvgetgdlcvldelrnpvsqetmppavpptddasdlsfsptshhdadrkaarreeatkntnitssrtedrlhspasssasfsssadsskaryesaafpedaslgekslfsslrgrqaregdasggsggsgfcdvpafpssaapelandrwllratQGHLRATQGHT--IR---------QVASDLLL-RSIC-----------------------DPGELP----VCVHGTFLKNW-MAIRSAG--LSRMHRNHIHFAPGLps----------------------ECGVVSGMRRS-SDVAIYVNVHLAMK-E------------GVRFYVSNNNVILTEGLNNNVILTEGLRGKLVPSSSKSTGM  1229  Toxoplasma gondii GT1                                    eukaryota>alveolata>apicomplexa
    198415504  211  420   SKELVRIVRHG--KYN-QQIQ--MDAE-GYVFVN--DI--LTCKRFY--------dqFPGVNELYIEKIVESND-KKRFELKFEe-------------------------------------------------------------------------------------------------------------------------------------------------------------gvGWKIKAAQGHT--VK---------IENRSL---RPIT-----------------------NPAEFP----VVIHGTYWENW-EFIKVNG--LNRMGRNHIHFAPGLpn------------------------EVVSGMRKS-CEVAIYINMTQALK-D------------GFKFFQSSNQVILTEQSSNQVILTEGDEKGRIHPKYFLKVV  590   Ciona intestinalis                                       eukaryota>metazoa
    157042782  216  26    SKSLSYVLRHG--ASK-MGLQ--MNSD-GFVFVE--EL--LAHQQFR------------SFSVDDVERVVASND-KQRFKLCKHp------------------------------------------------------------------------------------------------------------------------------------------------------------eddRLQIRANQGHS--VQ---------VTDLEL---REISq----------------------DDQDYP---REAVHGSYMKHW-PSIRSQG--LSRMNRTHIHLAPGLpg----------------------EGRVISGMRQS-CDLAVYIDVTKAMS-D------------GIKFFWSENGVLLTFWSENGVLLTPGDAAGILAPCYFSRAQ  196   Danio rerio                                              eukaryota>metazoa>vertebrata>actinopterygii
    197246418  219  24    SKCLSYALRHG--AVN-LGLP--MGTD-GFVPVS--SL--LLLPQFR------------TFSQVDIERVVSCND-KQRFTLRYSy------------------------------------------------------------------------------------------------------------------------------------------------------------adgALEIRANQGHS--LQ---------V-EVELTPL----------------------------GEELP---NQAIHGTYFRHW-PSIQQRG--LSRMNRTHIHLCTELpge---------------------GQECISGMRRD-CEVAIFIDLPKAVA-D------------GLLFFWSSNRVLLTFWSSNRVLLTPGNADGLLLPKYFLRAL  191   Xenopus (Silurana) tropicalis                            eukaryota>metazoa>vertebrata
    297267544  220  32    SKALSYALRHG--ALK-LGLP--MGAD-GFVPLG--AL--LQLPQFH------------GFSAEDVRRVVDTNR-KQRFALQHGd------------------------------------------------------------------------------------------------------------------------------------------------------------pstGLLIRANQGHS--LQgshcclfNQVPELELMPLE--------------------------TPQALP---PMLVHGTFWKHW-PSILLKG--LSCGGRTHIHLAPGLpg----------------------DPSVISGMRPH-CEIAVFIDGPLALAAD------------GISFFRSANGVILTFRSANGVILTPGNTDGFLLPKYFKEAL  211   Macaca mulatta                                           eukaryota>metazoa>vertebrata
    238550149  220  32    SKALSYALRHG--ALK-LGLP--MGAD-GFVPLG--TL--LQLPQFR------------GFSAEDVQRVVDTNR-KQRFALQLGd------------------------------------------------------------------------------------------------------------------------------------------------------------pstGLLIRANQGHS--LQv-------gVPKLELMPLE--------------------------TPQALP---PMLVHGTFWKHW-PSILLKG--LSCQGRTHIHLAPGLpg----------------------DPGIISGMRSH-CEIAVFIDGPLALA-D------------GIPFFRSANGVILTPGNTDGFLLPKYFKEALQLRPTRKPLS  230   Homo sapiens                                             eukaryota>metazoa>vertebrata
    327286590  221  99    SKALSYTLRHG--ADK-LGLA--MGAD-GFVDVA--EI--LRLPQFK------------AWSLEDVQRVVETNE-KQRFALRPHp------------------------------------------------------------------------------------------------------------------------------------------------------------sdaHLQIRANQGHS--LQ---------VSELELVPLL--------------------------NPSDFP---EIVAHGTYLHHW-PAIRKDG--LSRMGRSHIHLAPGLpg----------------------DAAVLSGMRNN-CEVAIVIDIAKALAAD------------GIPFFRSANGVILTFRSANGVILTPGDAQGLLLPCYFREAL  269   Anolis carolinensis                                      eukaryota>metazoa>vertebrata
    195016166  226  11    SKQLSWLLRHG--AQK-EGLT--IQPD-GFVSIN--EI--LKHSRFG-----------SQYTREKLRQIVSTDA-KQRYTLRSNp------------------------------------------------------------------------------------------------------------------------------------------------------------ltgAEEIRANQGHS--LK---------AVQSEVC-MERIG-----------------------SISELP---SAVVHGTYYSNW-ERIKIEG--LKRMQRNHVHFALFNgdgd--------------------NRAVLSGFRSD-CQVLIYLNVAKVLG-D------------QLPMFRSSNNVILCAGISNNVILCAGIDGCIDKRYFERAIE  188   Drosophila grimshawi                                     eukaryota>metazoa>hexapoda
    28575019   227  4     SKKLSWLLRHG--AKT-EGIT--IRAD-GFVSVP--DL--QKHPRYL------------CFTLEKLKEIAAADA-KQRYTLRWNp------------------------------------------------------------------------------------------------------------------------------------------------------------elgVHEIRANQGHS--LA---------VLEGEAGGLENIT-----------------------HVSQVP----LAVHGTYYRHW-GAIRSQG--LSRMNRNHVHFACSDe-----------------------TNSTLSGFRSD-CQILIYLNVEKVLA-D------------GIPIYRSSNNVLLCPGISNNVLLCPGIEGFIHSSYFQRVVD  185   Drosophila melanogaster                                  eukaryota>metazoa>hexapoda
    198471764  228  13    -KKLTWLLRHG--AVK-EGIA--IQPD-GFVNIS--DI--QSHPRYA------------VFSLPKLQEIVADDA-KQRYILRWNe------------------------------------------------------------------------------------------------------------------------------------------------------------dakFHEIRANQGHS--LA---------AVQGEAC-LERIS-----------------------NAKQVP----LAVHGTYYRCW-EAIKAQG--LGRMRRNYVHFAVSDv------------------------GETLSGFRSD-SQLLVYLDVAKVLA-D------------NLPLFRSSNNVILCAGVSNNVILCAGVDGFIDKTYFSRAVD  183   Drosophila pseudoobscura pseudoobscura                   eukaryota>metazoa>hexapoda
    91080221   231  9     SKTLSWLLRHS--AAT-EGLS--LTPE-GFAPVS--EV--LNHRQLR-----------GKFTVEDIQRIVESNN-KQRFFLRQNg--------------------------------------------------------------------------------------------------------------------------------------------------------------aILEIRANQGHS--MQ---------VTELELAS----------------------------YLNDPN---VDVVHGTFFRNL-DAIKRIG--LSRMSRNHIHFTRDL---------------------------AL--IRKN-VQVLIYIDVAKALS-D------------GIKFYMSSNGVILSYMSSNGVILSPGNEKGILEPKYFWKIV  168   Tribolium castaneum                                      eukaryota>metazoa>hexapoda
    298711928  238  59    SKRLTYALRHG--AEK-LGLR--LRPD-GFVSLD--EL--LSKPSFR------------GVSREQVEQVVASDE-KGRMTIATFp------------------------------------------------vsggeaagsasacadpgaatn-----------------------------------------------------------------------------------------qAVFIRANQGHS--VKg--------VIDEEKLLTRVE------------------------DAADVP----VCVHGTDRKSW-SNIREEG--LRCMNRTHIHFAAGLpg----------------------ESGVISGMRKA-CKVLIYVDVAAAMS-D------------GVAFFRSTNDGVAFFRSTNNPARTAPWSQGTSPALTALLLP  244   Ectocarpus siliculosus                                   eukaryota>stramenopiles
    198425598  207  535   ---LSSVLRHN----K-YGFK--VDKE-GYVPVD--AI--LKHQHFK----------KLGLTREEMHRIVREND-KQRFTIQVNed-------------------------------------------------------------------------------------------------------------------------------------------------------------gMEIIKANQGHS--VE---------VSSLNL---MTIT-----------------------DACEFH----DVIHGTFWTAW-KSIRKQG--LHCRKRMHIHMTTAEpns---------------------DQQVISGMRYS-CNVFVHIDMGQAIK-D------------GIPFFLSENKVILSFLSENKVILSPGDKNGYLRPKYFRKVE  700   Ciona intestinalis                                       eukaryota>metazoa
    291231763  206  401   SKKLSNILRHN--ANK-FGFQ--LDKG-GFLNVE--DM--LHHQHFR------------GYTIEDVKRVVTNND-KQRFALRNHpd------------------------------------------------------------------------------------------------------------------------------------------------------------snLLQIRANQGHS--VK---------VQGLEL---KRIT-----------------------DASEYP----TVIYGTYSKHL-ERIKEKG--LSRMGRNHIHFAPGMpd----------------------EVGVISGMRWD-CDVIIVLDLEKAIK-D------------GIEFMISANNVILSSGDEHGYILSSGDEHGYISV-------  577   Saccoglossus kowalevskii                                 eukaryota>metazoa>hemichordata
    145602059  162  26    SRALSRLLRHQ--AAN-AGIQ--LDGE-GYAPLD--KV--LAWGPIK----------SLKATLPEIREAVSSSD-KQRFSMKPLs-------------------------------------------------------------------------------astspds---------------------------------------------------------------------tdpaDFLIRANQGHS--IK----------LESAEHLTAVTV-----------------------EAGNVP---EVVVHGTYYAFW-PAIVASG-GLRPMGRNHVHCSTGLpss---------------------EAQVVSGMRRD-AELLVYLDVERALR-Dg-----------EMKWWLSDNGVVLTEGGQG------GLVPVKYFQGGLVPVK  223   Magnaporthe oryzae 70-15                                 eukaryota>fungi>ascomycota
    85109317   164  52    SRALSRLLRHQ--AAS-AGIT--LDAE-GYAPLD--KV--LAWGPIR----------SLKPTFPEILKAVKESD-KQRFAIKLApg----------------------------------------------------------------------------kekedgeks---------------------------------------------------------------------eepgDWLIRANQGHS--IK----------LESEGLLRRLVLgrgggggqqqqqqqgqetegedgGTIPIP---ETVVHGTYFAFW-DKIIQSG-GLKPMGRNHVHFSTGLpedt--------------------ERGVISGMRSD-AEVLVFVDVERSIR-DaeeaekedkegkGIKWWMSDNGVVLTEGDKD------GLVPLKYFKDGLVPLK  287   Neurospora crassa OR74A                                  eukaryota>fungi>ascomycota
    116192183  166  62    SRALSRLLRHR--AGD-AGVE--LDRE-GFADLG--RV--IQWGPIR----------ALAPTFSEILNAVHNND-KKRFTIKPNpa----------------------------------------------------------------------------tnpdldess---------------------------------------------------------------------tnpsEWLIRANQGHS--IK----------LDSEHLLKALALpadd----------kdgtaalpeGAVAIP---PAVIHGTYFAFW-PSIVASG-GLKPMGRNHVHFSTGLpeds--------------------EAGVVSGMRRD-AEVLIYVDVAASLK-Dg-----------GIKWWISENGVVLTEGDVN------GLVPLKYFVNGLVPLK  276   Chaetomium globosum CBS 148.51                           eukaryota>fungi>ascomycota
    312220715  174  15    SKKVSWLLRHG--AAS-EGLK--LGKG-GYVNVQ--DA--LNTKTLK----------SLSVTFPELREVVANND-KQRYSMILAs---------------------------------------------------------------------aldgtdtaqppqenpes---------------------------------------------------------------------dkpsDYLIRANQGHS--IK----------VDTDGLLTPITQ-----------------------EAGNIP---ETVIHGTDEPAW-NLILKSG-GLRRMGRNHIHFASGLpagfkplapstdsaedhke-----SAPVISGMRKN-SSILIYIDIEAALA-A------------GIKFFVSENGVILSEGNEQ------GLLPYEFFEQGLLPYE  245   Leptosphaeria maculans                                   eukaryota>fungi>ascomycota
    224002288  181  59    SKSLSWVLRHS--APS-LGLR--PSPD-GYFSVE--DM--LSLKHPRfcnkgsshngGRKYTVDDIRRVVESSD-KQRFRLEYKd-------------------------------------------nqylakmmkhekssdrgetaatsnakestnapakldgssdnes-----------------------------------------------------------------------nlVLCIRANQGHS--FS--------KHIESDKLHTPLTK----------------------eELSDPNL---TIVHGTTRKAWEDHIRIEG--LSRMKRTHIHFATGLpts---------------------DNKPISGMRAT-SQIYIYINGEKCAK-D------------GVPFFKSDNGVILTAGVNEF-----DGLPVKYF--------  303   Thalassiosira pseudonana CCMP1335                        eukaryota>stramenopiles
    219121541  182  5     SHRLSYVLRHG--ALD-MGLE--MTAD-GYVPVD--SL--LILQHPKfi--------GNQWTLQDIRDVVSDSD-KQRFKLREKp--------------------------------------------------------------------------------------------------------------------------------------------------------------aSDYGQATQRHT--IS---------FIKPELLLVRLSA----------------------eELRRIP----TIVHGTYSALW-PAIQISG-GLSRMKRTHIHCASGLig----------------------ENGVISGMRRG-CDVYIYINAEACAD-A------------GVVFYRSDNGVLLTAGIKI------GGLPCKY---------  199   Phaeodactylum tricornutum CCAP 1055/1                    eukaryota>stramenopiles
    226471272  209  101   SKKLACILRHA--AEN-VGMN--YEPG-GYLYVD--KI--LQLKPFQ------------GVRVEDILRVVNSND-KKRYEVSTNpe------------------------------------------------------------------------------------------------------------------------------------------------------------ngRLKIRAFQGHS--VP---------IDGLDI---TLIE-----------------------NPENYP----NVIHGTYFRNW-ESIRKEG--LKRMRRTHIHFAPGEig----------------------ESGVISGLRSS-AEILIYIDLAKAMK-D------------GYKFYISKNNVILCEGNAD------GCLPTKYFADGCLPTK  282   Schistosoma japonicum                                    eukaryota>metazoa
    225707394  217  31    SYSLSFTLRHG--ANK-LGLH--MNPD-GFLFVE--DL--LAHPQFR------------SYSLEDVERVVAAND-KKRFKLCRHp------------------------------------------------------------------------------------------------------------------------------------------------------------edgRLQIRANQGHS--LQ---------VPDLEL---RPVQa----------------------GSPNCP---VEAVHRSYLCHW-TSIRTQG--LSRMARTHIHLC--Lpg----------------------EEGVAGGSSDV-RDLAIYIDVPKALA-D------------GIQFFLSENGVLLTPGDTE------GKLPLKYFTEGKLPLK  212   Osmerus mordax                                           eukaryota>metazoa>vertebrata>actinopterygii
    320168635  233  31    SKLLSYILRHG--------VP--ISPE-GFVDVE--VL--LGFPDFR------------AYTVADVRRAVTSSD-KQRFALEERi---------------------------------------------------------------tddnpv-----------------------------------------------------------------------------------------aRLYIRANQGHT--IE---------VEALELSPIT--------------------------ASEDAP----IVVHGTYDAAW-DLIKSQG--LSRMKRNHIHFAVGLpg----------------------ASGVISGMRSD-VTVLIYLDVARALA-D------------GIPFFRSSNNVILSPGLEN------GSIPAKYLENGSIPAK  210   Capsaspora owczarzaki ATCC 30864                         eukaryota
    66358336   243  10    SKKLTWLLRHGD-PAK-TGLN--MRND-GYVEVN--EI--LKQT---------------CISLEKLHYIVENDP-KGRFRIIDEn--------------------------------------------------------------------------------------------------------------------------------------------------------------gKNLIRANQGHS--LS---------FIEDEKLLARFEI--------------------dnnSEFIQR----IIIHGTYLDKW-KNIKING--LSRMSRSHIHFVSATnf----------------------KLESIKQGSKI-SEDMCIDQIVREMC-Ny-----------KCTAGIRPNYKCTAGIRPNC-----EVLVFIDVVNCVTNSA  176   Cryptosporidium parvum Iowa II                           eukaryota>alveolata>apicomplexa
    310831101  247  1     SKKLSYYLRHN------LDIFN-YSKD-GYVKIS--EL--REKNIIK-----------KNTTIDAIDKIVKNDS-KNRYDLKFEi-----------------------------------------------------------------nngy-----------------------------------------------------------------------------------------kEYYIRANQGHS--SG---------NLDYSLILEE--------------------------IKEPIP----NIFHGTFIKKI-DSIKNTC--LNKMTRHFIHFAAD-------------------------DIIHNHLKRSI-SQVKVYVDMKKAMD-D------------EIKFYYAKNKVILSNGKNND-----GIIPAKYNNDGIIPAK  184   Cafeteria roenbergensis virus BV-PW1                     dsdna viruses, no rna stage
    110645302  248  14    SRSMCYLLRHD------RNFI--TSSD-GFVSID--TL--AKKL---------------NISNQQITEIAHRDS-KNRYEINN------------------------------------------------------------------------------------------------------------------------------------------------------------------DMIRAVQGHS--NR---------HVDFKMDKV---------------------------AINYKG----IAVHGTFKKHL-NSIISHG--LKRMSRNHIHLATS----------------------------KNNARKN--ANVFIYINIRHCLK-D------------GMIFYFSSNGYILTMGFD-------GTIPSKYIVKYEFASK  174   Neodiprion abietis NPV                                   dsdna viruses, no rna stage
    302851356  255  501   SKEMSRLLRHKP-PPG------AMDAA-GWVSLP--VL--LRHMR-------------NHPSEEQVRRIVETCD-KKRFVIDDSv--------------------------------------------------------------------------------------------------------------------------------------------------------------nPPRIRAAQGHS--VE---------LTEAVLEPV--------------------------vDPSKVP----IAVHVTSVSSW-EAIRTSGQ-LMRMNRTHIHFATE---------------------------PHHMRKNKW-AEIYLRLDLAAALE-Q------------GRQFFLSSNGVLLCE----------GPVPVSLVEEGPVPVS  678   Volvox carteri f. nagariensis                            eukaryota>viridiplantae>chlorophyta
    307104106  256  1     -----------------------MDAS-GFVPLP--VL--LQELR-------------SPGATEAVVRHVVASDLKGRYELDESs--------------------------------------------------------------------------------------------------------------------------------------------------------------vPPRIRAVQGHS--VH---------LAAPQLAPV--------------------------gSADEVP----LALHITSLEGW-KAIQDSGE-LRRMSRTHVHFGTE---------------------------PGHLRRNSW-ATVLLRLDLRQAMQ-D------------GHAFFLAANGVLLCE----------GPLPARYLEEGPLPAR  155   Chlorella variabilis                                     eukaryota>viridiplantae>chlorophyta
    157126123  259  57    ---FSWLLRH---SAA-VAEH--MDPD-AFVEFE---V--LQQI--------------SGASKDRMLELIAQDQ-KGRYEIRG------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVRAVNGHS--VH---------FCDNYEVL----------------------------SGERRP---EFLYHATNDKAL-PLIMAGA--LKRMGRHYIHMYDGPpq------------------------KTSVRYR------ILRIRPL-----P------------GHTLYRTKNGYILCR----------EDIPAEFIEREDIPAE  210   Aedes aegypti                                            eukaryota>metazoa>hexapoda
    262195534  260  6     SRRISSLLRHR--AGD-AGLS--MDAA-GWVEID--AL--LAHL---------------GESRELLDAVVQTNN-KARFEVAG------------------------------------------------------------------------------------------------------------------------------------------------------------------TRIRASQGHS--LEnmpv-----TRDALEAS----------------------------WSRFDGE--DSLWHGTQPEVV-ESIARDG--LLHGARSHVHLAESR--------------------------DSSVGKRSN-VGVLLEISPSELRA-A------------GWELFKSPNGVILCR-----------HVPPECILCRHVPPE  176   Haliangium ochraceum DSM 14365                           bacteria>proteobacteria>deltaproteobacteria
    284033571  261  2     SKRLSWLLRHG--AGE-QGLA--MTAD-GWASIE--DV--CVLT---------------DISRPALDRAVERND-KNRLEVDG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRIRACQGHS--LAgmpv-----TREALENS----------------------------WRRVHPA--DLLWHGTTRAAV-EAIRREG--LKPGRRTHVHLAPSR--------------------------DSHVGKRFA-AAVLLAVDPVDL------------------VVFEAPNGVLLTR-----------QVPPDAILTRQVPPD  170   Kribbella flavida DSM 17836                              bacteria>actinobacteria
    162450235  262  1     SKKLSWLLRHA--APS-QGVA--MDDA-GWVAVD--DV--LKAL---------------RISRPVLDEVVEKNT-KNRLEIRG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRMRASQGHS--RDgmpv-----TLAGLEAS----------------------------WEEVHDD--ASIWHGTSVDAV-RGIARDG--IRPAARTHVHCTDAL--------------------------GSAVGKRAK-VDVMLEISPARLRA-R------------GVRVFRSQNGVILVR-----------EVPVQCLLVREVPVQ  177   Sorangium cellulosum 'So ce 56'                          bacteria>proteobacteria>deltaproteobacteria
    20094870   313  39    SKLLSGILRHF--PEE-VKVK--LDDE-GFTDCDVHEL--AERIKKYw----knreyYRWLTGEHIIAVVETCP-KGRFEIDEH-----------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHSRRLS----------VRPTL------------------------------PEAENV---KELYHGTARENL-ESILQHG--IKPMGRRAVHLTDDE------------------------REALITALRHTRNPVILVVDAERLRR-H------------GLVPRKAGKNVYVVEG----------TVPPDCITRVIRNPR  218   Methanopyrus kandleri AV19                               archaea>euryarchaeota
    118430933  314  40    SKTLAGILRHH--PGR-YGVR--LTRE-GWARVS--EV--VEGLRKA---------gWSWVEEWHIVGVALHDP-KGRYELRN------------------------------------------------------------------------------------------------------------------------------------------------------------------GEIRARYGHS--IP----------VNVEP------------------------------LPGEPP---PILYHGTTEEAL-PLIMERG--IMRGRRLKVHLTSSL------------------------EDAVSTGRRHGNLVAVLLVDVECLRR-R------------GLKVERMSKTVYTVD-----------WVPPECIAEVRRESL  208   Aeropyrum pernix K1                                      archaea>crenarchaeota
    119871538  315  35    SKLLSLALRHS--PHV-LGIT--LDVE-GWADIN--AV--VEGLRRA----------GLPASPQVLKAVAQLDD-KGRFEIRD------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVRARYGHT--IK----------VQIRY------------------------------EVDLDT---RLLYHGTALYVL-PSILSQG--ILPMRRLYVHLAVDV------------------------ETACLNARRRQ-NPAVVEVDADCVRK-S------------GNPIYKATEKIRLTP-----------YVPPTCVKKWAICPT  199   Pyrobaculum islandicum DSM 4184                          archaea>crenarchaeota
    18314222   316  35    SKLLSLALRHS--PSV-LGLS--LDKG-GWADVK--TA--LEGLRKA----------GIRADYEALYAVVALDE-KGRFELKD------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRARYGHT--ID----------VEVEY------------------------------EADSES---KVLYHGTSRHLL-PSIMAQG--LLPMRRRYVHLSPDF------------------------ATACQNARRRP-LPVVIEIDAECLRA-R------------GYVVYAASGKVRLAK-----------HVPPECLKKVVDCPT  203   Pyrobaculum aerophilum str. IM2                          archaea>crenarchaeota
    145591275  317  38    SKTLSLALRHS--PAV-LGLV--LDSR-GWGEVE--AV--LRGLDRA----------GLKISREALEAVVALDD-KGRFEMSN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRARYGHS--ID----------VEVEY------------------------------EVDEDS---ASLYHGTSKDNL-PFIMAVG--ILPMKRKFVHLATDV------------------------DTACLNAARRP-SPIVIEVDAECLRR-S------------GVVIYIGSRKIRLAK-----------YVPQSCIKRVFQCLS  204   Pyrobaculum arsenaticum DSM 13514                        archaea>crenarchaeota
    126460155  320  34    SKLLSLALRHS--PSA-LGMS--LDEG-GWAPLD--AV--VAGLKKL----------GLPASAEAVEAVAQLDK-KGRFELSN------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHS--VS----------VKVDY------------------------------EVDTET---RRLYHGTTRRSL-EGIMKMG--ILPMNRLYVHLAVDF------------------------YTACETAARRQ-DPVVLEVDADCARA-A------------G-PIYKASPAIRLSK-----------YIPPTCITGVYPCEK  197   Pyrobaculum calidifontis JCM 11548                       archaea>crenarchaeota
    305663054  322  43    SKLMSFLLRHD--PES-IGLK--MDSS-GWVYID--DL--VDGIRNRw----rnshlYRWVEKEHVIAIAMLDP-KGRFEICG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRIRARYGHSKNLD----------IEIDY------------------------------PRDIET---KILYHGTAREFI-DRISIEG--LKPMNRHYVHLTIDM------------------------VDACIVGERHSGNPVVLKIDADCVRS-H------------GIDIYIASKSIRLAK-----------HVPRKCILAKHVPRK  218   Ignisphaera aggregans DSM 17230                          archaea>crenarchaeota
    307595891  323  37    SHLMTYLLRHD--PSA-VNLS--MDSE-GWVSID--EL--VHALRDKw-----dpkaYSWLTKEHIMAVASLDP-KGRFEIRD------------------------------------------------------------------------------------------------------------------------------------------------------------------GMIRARYGHNKSLD----------VNIRY------------------------------EVDSEV---RTLYHGTTKRAL-VRIMREG--IKPMNRKYVHLVLDP------------------------RDAYEVALRHGNDVVILKINVDCLRR-N------------DQQILIATDRIRLTD-----------YVPPQCIETDYVPPQ  212   Vulcanisaeta distributa DSM 14429                        archaea>crenarchaeota
    126465464  326  49    --------RHY--PWE-AGLR--IDSE-GWVDID--EL--VEGIKTRw----rnneiYQWLSREHIIAVAKLDP-KGRFEIRN------------------------------------------------------------------------------------------------------------------------------------------------------------------NKIRARYGHS--IN----------VKIKY------------------------------ELEYPP---TQLYHGTSIDKL-AKIMIEG--LKPMKRQFVHLTTSL------------------------ENAVETGKRHGK-PVVLIIDTMCLKE-K------------RIPLYKATEKIYLAP-----------KIPPQCILAPKIPPQ  213   Staphylothermus marinus F1                               archaea>crenarchaeota
    124028223  327  28    SKLMTTLLRHL--PHE-AGLR--LDPQ-GWVGID--EL--VRGIRERw----rnrhlYQWVTRDHVIAVALLDP-KGRFQLDLA----------------------------------------------------------------------------------------------------------------------------------------------------------------RGRIRAAYGHT--VR----------VELGY---------------------------rplSMDELP---DKLYHGTVAENL-ASILSEG--LKPMRRLMVHMTTDY------------------------SSAVETGRRHGPNVVVLVIDPRCLAK-H------------GIPVYRASDTIYLAP-----------SVPPNCILAPSVPPN  215   Hyperthermus butylicus DSM 5456                          archaea>crenarchaeota
    315230724  330  35    SKLMTYILRHS--PWE-FDLN--PDDF-GFIELD--EF--IKALKSV----------YPWVKEEHVRAVAELDP-KGRFEIRE------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRARYGHS--YE----------VFLDH------------------------------EEDTES---RTLYHGTPRKNL-DSILKEG--LKPMKRRFVHLTKDK------------------------TEAYYTGLRHGKDVVILVIDAECLRR-K------------GYRIYKAGKNVRIVK-----------YVPPECIVLWEVPPE  211   Thermococcus barophilus MP                               archaea>euryarchaeota
    156937278  331  2     SKKMTYLLRHK--E-G-F-VD--PE---GWASLD--SL--VRELRKF----------FPWVSKEHVLEVISKDD-KGRYELRG------------------------------------------------------------------------------------------------------------------------------------------------------------------DKVRARYGHT--VK----------YVRPT------------------------------LEESYE---TLLYHGTSCEAA-RAILKEG--IKPMKRNFVHLTTSL------------------------EEAIENARRKGKCIKVLIVDGECLRK-R------------GIKIYKAGKHVRVCS-----------YVPPECVVGEAVPPE  174   Ignicoccus hospitalis KIN4/I                             archaea>crenarchaeota
    284163819  337  32    SKFVSGALRHF--PED-VGLE--LDAH-GWTDYE--AL--AGAVEAK----------YDWAEPCHVAAVIATDP-KGRFERTDA--------------------------------------------------------------------sgtddga--gn----------------------------------------------------------------------------------GLVRASYGHS--VD----------VDLGP------------------------------TDEPVP---DELYHGTAPATL-ASIREDG--LRPMSRQQVHLSGSR------------------------EAARRVGQRHANDPVVLVVDATAMLA-D------------DQRITKRGRETYTTD-----------AVAPEYIDFPAVAPE  221   Haloterrigena turkmenica DSM 5511                        archaea>euryarchaeota
    55379941   338  30    SKFVSGALRHF--PED-AGIE--VDKA-GWTGFD--AL--RVAVERQ----------YDWADAAALAGVIATDP-KGRFERTGV---------------------------------------------------------------------gneagittag----------------------------------------------------------------------------------GRVRAAYGHS--VD----------VTLDG------------------------------TDDPVP---ATLYHGTAPRNV-DSIREAG--LKPMSRQTVHLSESA------------------------AAAREVGRRHAADPVVFVVDATAMQS-D------------DRRIVKRGTETYTTD-----------RVSPVYLTTDRVSPV  217   Haloarcula marismortui ATCC 43049                        archaea>euryarchaeota
    11499148   341  25    SKFLSGLLRHF--GRD-FGVR--LDED-GWAELR--DV--LKILSER----------Y-GVGRKHVELIVKFDP-KGRFELKN------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRAKYGHS--VE----------VRTDW-----------------------------sEGGEIP---EKLYHATSPENL-NSILKTG--LLPMRRREVHMCSSP------------------------QEAIEVGKRHSSNPVLLEIDAKGLMQ-D------------GIEVRRKGK-VYTVD-----------FVPPKFITVDFVPPK  200   Archaeoglobus fulgidus DSM 4304                          archaea>euryarchaeota
    327400244  342  2     SRFLSGLLRHF--PHK-FGVK--VDSE-GWASLE--DV--ERVIKER----------Y-GAGMDIIRHIVNNDP-KGRFEIKD------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHS--IA----------INTRW-----------------------------sEDGSIP---PKLYHGTRPEVV-KSIMQHG--LLPMRRLEVHLSGSV------------------------EEAIDVGRRHCPKPVVLEIDAEGMMG-E------------GIEIRKKGS-VYTAD-----------FVPPKFITADFVPPK  174   Archaeoglobus veneficus SNP6                             archaea>euryarchaeota
    288932585  343  33    SKFLSGILRHF--PDS-FGIR--LDKN-GFADLD--EV--IRILRER----------Y-GVGKREVEAIVLFDK-KGRFEIKD------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRARYGHS--VK----------VDYRW-----------------------------sEEGKIP---EKLYHGTKPENV-KSILKLG--LLPMKRNEVHLSESI------------------------DDAIEVGKRYCKNPVVLEIDAKKMLE-D------------GFEIRKKGR-VYTTD-----------YVPSKYITTDYVPSK  199   Ferroglobus placidus DSM 10642                           archaea>euryarchaeota
    147919656  348  40    GKIISGALRHF--PAD-LGLD--MDEH-GWVSLR--DL--TRVIERK----------YEWARSYHVDAMFKTDD-KGRYERKG------------------------------------------------------------------------------------------------------------------------------------------------------------------DKVRARYGHS--LN----------IKPDY------------------------------PEFDGD----KLYYGTSEEEA-DRILEIG--LKPVNQHFVHLSKSI------------------------EEAVKVACIRTEHPVIIEVDAKKARE-T------------GIEILDAGP-VCLTA-----------QIPAEFLQIGQIPAE  208   uncultured methanogenic archaeon RC-I                    archaea>euryarchaeota
    20093417   349  27    GRFVSGTLRHF--PAS-AGVK--MDEY-GWVDLN--AF--CDVMKKR----------YNWMRKEYLYALVESDE-KGRYQIRG------------------------------------------------------------------------------------------------------------------------------------------------------------------FMIRARYGHS--VN----------IELDY------------------------------EESDAP----YVYYGASPEEV-DVLLENG--IFPIKQRYVHLSTSY------------------------EKAAEVALIHTESPVILQVDAFRAQE-D------------GISLKLATDYIVLAE-----------KIPPEYLYVIEEPPE  202   Methanosarcina acetivorans C2A                           archaea>euryarchaeota
    336475983  350  27    GRFISGVLRHF--PRE-VGLK--MDDE-GWVDFE--LL--CSLLKSR----------YKWATRERLISLVESDE-KQRYEIDD------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIRARYGHS--VD----------VDLDY------------------------------PDNELP----SLYYGVSQEEV-DMLLENG--ISPIRQTYVHLSTSY------------------------GKAVEVAQIHTENPVILEIDAEKARR-D------------GMSIMDANEDIALME-----------YVPSDYVCIFDGRSD  202   Methanosalsum zhilinae DSM 4017                          archaea>euryarchaeota
    294494713  351  27    GRFVSGVLRHF--PDD-VGLD--MDAQ-GWIELD--AF--CEAMKKR----------YKWAGKMRLVSLVESDP-KQRYEIDN------------------------------------------------------------------------------------------------------------------------------------------------------------------SFIRARYGHS--ID----------VDLDY------------------------------PLYDSD----VLYYGVSQEEV-DMLLENG--IKPYRQTYIHLSNSS------------------------QRARQAASVHTDNPVILEIDAASAAK-D------------GYEFLCANEEIVLSK-----------EILPEYIEIADDLPE  203   Methanohalophilus mahii DSM 5219                         archaea>euryarchaeota
    288931212  354  29    GRFISGLLRHY--PDK-YRLE--MDEN-GWVDFG--KL--VRVVKRR----------FKWANQWLVKAIVYSDE-KGRYEISN------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRARYGHS--VD---------NVKLDL------------------------------PEAEEE----TLYYGTSEEEA-SRVMEVG--IKPVNRRYVHLSTTL------------------------EKGEEVARLRTDEPIVLVIDAKEAKK-D------------GIRFIKVNENIVLAE-----------EIPPKYIKDFEIPPK  208   Ferroglobus placidus DSM 10642                           archaea>euryarchaeota
    330508961  355  26    GRLVAGGLRHF--PLD-LGLE--MDSR-GWIDLS--KL--GEVVQKR----------HRWANKEMVIALAQSDP-KQRYEISN------------------------------------------------------------------------------------------------------------------------------------------------------------------QRIRARYGHS--MD----------IELDH------------------------------PECHLP----RLYYGASEEEA-DRILEIG--LKSASQRYVHLSTTP------------------------NKAWDVAGYRTGNPKVIQVDAAPARE-A------------GVKMMTVNDDIVISE-----------MIPARFLCILASKDI  201   Methanosaeta concilii GP6                                archaea>euryarchaeota
    116754706  356  37    GRLLAGALRHF--PDD-LGLA--MSPQ-GWVEIP--VL--VDAIRTR----------YRWANENLVMALVRSDP-KGRYEING------------------------------------------------------------------------------------------------------------------------------------------------------------------TRIRARYGHS--VG----------VDLDY------------------------------PENELP----TLYYGTAEEEA-ERLLEVG--LKSATQRYVHLSTTP------------------------DKAWEVGTFRTSNPKIIVVDAAGAQR-E------------GVRMMKVNESMVISD-----------PIPPRFLSMMPAKAQ  208   Methanosaeta thermophila PT                              archaea>euryarchaeota
    167043400  361  28    ARRLALVLRHA--PEK-FDLE--MDIN-GWIDVK--DI--VKQFKGSne------rrYHWFRPHHIRAISETDP-KGRYEVRG------------------------------------------------------------------------------------------------------------------------------------------------------------------NVIRATYAHT--VE----------IELDL------------------------------PTDNIP---DALYYPCSPDEY-ENLIEVG--ISPSGRAHVHLSANI------------------------RSAAEAGHVHHAIPTLLEVDTARLVA-A------------GETVWHAGITVYLAE-----------FVPGKYLLAEFVPGK  208   uncultured marine microorganism HF4000_APKG1C9
    10639263   362  1     SRTLAAILRHD--PER-YHIR--LDSH-GYARIA--GI--VTVLRKYk--------gMKWITFDHILSLAETDP-KGRYQVSG------------------------------------------------------------------------------------------------------------------------------------------------------------------VLIRAMYGHT--IP---------VDLSDL------------------------------PEDNIP---DVLYYQSSAAEA-PLVKEAG--IYPSDKTWVHLSGTY------------------------RRSYVSGLYHIDDPFILRIDARSMID-S------------GHDIYRSSDDIYLTR-----------EIPPEYILTREIPPE  180   Thermoplasma acidophilum                                 archaea>euryarchaeota
    254169141  363  29    SRMLAGILRHF--PER-FGVK--LDDS-GWADIY--QI--VKGIKRRh-------prFRWLKDKHIIAIVLTDD-KGRYQLDME----------------------------------------------------------------------------------------------------------------------------------------------------------------NKRVRATYGHS--IK---------VDLSDL------------------------------PTDNIP---EKLYYPTTEEEY-EYIKEIG--LQPGDRKWVHLSKTY------------------------RDAYIAGLHRVEEPIILEIDTKKAIE-N------------GHQIYRAAKTVFIAS-----------QIPPEFINISQIPPE  213   Aciduliprofundum boonei T469                             archaea>euryarchaeota
    29830778   369  902   SRSLSYHLRHG------RELT--QNPQ-GWVPID--SL--VRALDPK-----------LRVSADELISVARAVS-EERFEVRG------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVRARYGHS--RP----------TAIEY------------------------------EIRAPE---GRLYHCTPTTAL-HNIFERGEGLRPMTRQWVHLTTDR------------------------AAALSAGRRHGPCTLLCVPDPSAL------------------ECRHAGGATWLVA-----------QVPPSALTVVPLHRL  1051  Streptomyces avermitilis MA-4680                         bacteria>actinobacteria
    228983067  370  4     GGFLCKILRHS--PSQ-FHVS--LDEY-GYAPID--EL--LNAISSNe-------kwVNLVTVEMILEVVKTDE-KQRYKLDST----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIKARYGHS--IA----------VKSDE-----------------------------eQNRVLP---DILYHGTGMEHL-DSIQKLG--LLPMKRVNVHLSETT------------------------FFANKSAKRNQ-FPVLLKVDTIMAKN-L------------GVTVEYAGDEVWLSS-----------PIPSDCLLSSPIPSD  185   Bacillus thuringiensis Bt407                             bacteria>firmicutes
    251794334  371  5     SKLMTKILRHT--PEQ-FGIS--LDPEDGSCGIH--VL--LEAIQAQp--------kWAGITIEDIEQVVRNSE-KQRFAIED------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHS--HD-----------RVQY------------------------------TAGEPP---AILYHGTNRKAL-PSILGEG--LHPMNRQYVHLSEGT------------------------HFATLAGSRRG-ELVILKIDTSRAKE-A------------GVVFFFAGNEVWLAD-----------RVPADVWLADRVPAD  180   Paenibacillus sp. JDR-2                                  bacteria>firmicutes
    310641074  372  11    SKFMSEILRHT--PEQ-FGLE--LDHE-GYCDIQ--DL--LRGIRSEd--------rWSDVSESDIKQVVSHCP-KQRYEMVN------------------------------------------------------------------------------------------------------------------------------------------------------------------GYIRANYGHS--AG-----------KLNY------------------------------EEATPP---TILYHGTNTKVI-HNLFTEG--IKPMGRKYVHLSESL------------------------EFAILAGKRRG-ELVILEVDTAKALA-N------------QVKFYKANHGVWLAD-----------LVPPQYLLADLVPPQ  178   Paenibacillus polymyxa SC2                               bacteria>firmicutes
    334135982  373  11    SKLMSKMLRHS--PGD-FGLV--LDGE-GFCSLG--DF--LTALNRVs--------gFEDVRPEDIQRVVRECE-KQRFEIAE------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIRARYGHS--HE-----------RITY------------------------------EAAEPP---SVLYHGTNRKAV-ALIMAEG--LLPMSRQYVHLSEGL------------------------HFAALAGKRRG-ELVILEVDTALAGH-K------------GVRFYYAGNEVWLAD-----------RIPAEVWLADRIPAE  176   Paenibacillus sp. HGF7                                   bacteria>firmicutes
    116495334  267  1     SKTLSMLLRHH--PEK-LGLV--LDQY-GRTDWK--TL--VRRFNAH---------yQMHLDRQVLQAIMAQST-KKRFALEG------------------------------------------------------------------------------------------------------------------------------------------------------------------TTIRAVYGHS--VP-----------------VMPLT-----------------------PATEPP---QWLYHGTSHQAA-TVIAKEG--LLPMNRDFVHLSEDV------------------------ATARQVGARHDTHPVIYRIAARDAAK-N------------GILFYPTSSRVWLVS-----------ELPARFLLVSELPAR  178   Lactobacillus casei ATCC 334                             bacteria>firmicutes
    227508115  268  13    SKRLSFILRHH--PEK-IDIK--LDQY-GRTNLN--VL--IRHFNKH---------yGTPISQSIITAIIQQSD-KQRYAIEG------------------------------------------------------------------------------------------------------------------------------------------------------------------NTIRALYGHS--IP-----------------VKPLT-----------------------PPKMPP---EYLYHGTTHSAA-RLIETEG--LKKMDRDFVHLSANQ------------------------QMAIQVGRRRDPRPVVFRVAAKNAAK-N------------NVLFYPTKSGIWLVD-----------AMPAQFLEVDAMPAQ  189   Lactobacillus brevis subsp. gravesensis ATCC 27305       bacteria>firmicutes
    338811714  270  5     SKTMSYALRHA--PWE-YELE--MDEG-GWVSII--QL--LHSLQEE--------qkWSDVKAENIYYVAKTSD-KGRFEIAD------------------------------------------------------------------------------------------------------------------------------------------------------------------SKIRALYGHS--IP-----------------LRIIK-----------------------APGEPP---QLLYHGTSRQEA-DAIMANG--LEPRGRQYVHMAVDP------------------------KMALQVGKRRDNKPVLLTIKAREARQ-D------------GVAFYKGNDLVWLAE-----------FVVAKYIDIEFVVAK  178   Acetonema longum DSM 6540                                bacteria>firmicutes
    303240380  271  7     SKAMSYALRHA--PWE-YELE--IDEH-GWVNIE--HL--LYSFHEE--------kkWSELEIKDIIYVVENCD-KKRFEVDD------------------------------------------------------------------------------------------------------------------------------------------------------------------KRIRALYGHS--VP-----------------QKIIK-----------------------EPMQPP---EILYHGTAKRFL-SMIKEKG--LIPKGRQYVHLAVDS------------------------DMALQVGKRRDDHPALLIINSRDAWN-E------------GIKFYKGNEKVWLAD-----------FIDSQYIEADFIDSQ  177   Acetivibrio cellulolyticus CD2                           bacteria>firmicutes
    256006093  273  2     SKEVAYALRHA--PWE-YGLE--LDAE-GWVDIN--QL--LSSLHEC--------ekWKKVSEHDLHVMIEKSD-KKRYEISN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRALYGHS--IP-----------------QRIIK-----------------------EQKCPP---EVLYHGTARRFV-KSIKEKG--LQPQGRQYVHLSADV------------------------ETALQVGKRRDIKPVLLIVNALEAWS-E------------GIKFYLGNDKVWLAD-----------AIPSKYIRFDAIPSK  178   Clostridium thermocellum DSM 2360                        bacteria>firmicutes
    295093305  275  2     SKEVSYALRHA--PWE-YELE--MDEE-GWVSVE--QL--VDALNKD--------mkWIGTSEDDLLVMIDKSE-KKRHEISG------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRAFYGHS--IP-----------------MHIKK-----------------------EKMIPP---DILYHGTARRFL-SSIKING--LLPQGRQYVHLSQDI------------------------STAQSVGLRRDNKPCVLQIDAKRAWE-D------------GILFYFGNEKVWLAD-----------VIPSKYILADVIPSK  177   Coprococcus sp. ART55/1                                  bacteria>firmicutes
    49477941   276  1     SKEVSYALRHA--QWK-YELE--LDEN-GWVSVE--QL--LHALHQS--------ieWRDVKIEDLKIMIEKSE-KKRHELKE------------------------------------------------------------------------------------------------------------------------------------------------------------------NKIRALYGHS--IP-----------------MKIVK-----------------------EEGVPP---EFLYHGTSPRFL-NSIESNG--LSPMSRQYVHLSEDI------------------------ITAELVGKRKDKHPIILEVNTGKARE-E------------GVKFYLGNEKVWLAD-----------EIPSEFILADEIPSE  180   Bacillus thuringiensis serovar konkukian str. 97-27      bacteria>firmicutes
    304405428  278  1     SKEVSYALRHA--PWE-FELE--LDAE-GWVAVE--QL--LHSLRHQ--------aqWTSISEADLATMIDQSE-KKRHELAD------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRALYGHS--VP-----------------AKIIK-----------------------NIERPP---AVVYHGTARHLL-ETILAAG--LKPMGRQYVHLAVDQ------------------------ETAITVGKRKDSEPALLAVDAQKAWQ-D------------GIRFYRGNHSIWLAD-----------QVPPIYILADQVPPI  179   Paenibacillus curdlanolyticus YK9                        bacteria>firmicutes
    325108247  281  3     SRAMSHALRHE--PWV-YELE--LDEE-GWTSTE--RL--LSALRKQ-------kskWRNVTERDFVRLMESAT-KQRYEMAD------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRAFYGHS--VT-----------------GLLKK-----------------------TPAEPP---AVLYHGTSPEVV-EFILAEG--LRPMARQFVHLSTEI------------------------VTAKEVGRRKCKVPVILQIDSPLAVQ-Q------------GSCFYLGNEMVWLAD-----------KIPEMVWLADKIPGN  178   Planctomyces brasiliensis DSM 5305                       bacteria>planctomycetes
    339009751  282  1     SKEISYALRHA--PHE-YELE--LDEY-GWVQTE--QL--LHSLHEQ--------pvWRNVSEKDLQVMISQFD-KKRFEMEN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKMRALYGHS--TA-----------------KRVLK-----------------------EESEPP---EFLYHGTPKRFV-SLILEQG--LLPKGRQYVHLSEEI------------------------QTAKQVGKRRDTHPTILKIEAKKAWA-N------------KVTFYHGNEMVWLAD-----------KIDRQYILADKIDRQ  176   Brevibacillus laterosporus LMG 15441                     bacteria>firmicutes
    319936601  285  1     GKEISYVLRHH--PEK-YNLD--IDNE-GWVDVG--DL--LNALESR----------FGLLKEEDIVALMQQSE-KERYELKN------------------------------------------------------------------------------------------------------------------------------------------------------------------HRIRAYYGHS--FS-----------------KKIMK-----------------------QRNIPP---KVLYHGTARRFV-SSILTTG--LQPMSRQYVHLSQDV------------------------ETAKQVGMRHDTQPVILMINAQSAFQ-D------------GVAFYLGNEKVWLSE-----------TIPPQYIEERKQPPQ  175   Coprobacillus sp. 29_1                                   bacteria>firmicutes
    332361966  286  6     SREVSYILRHN--PDK-YGIK--LDSE-GWCSVD--DL--IHNLSET--------plWKGLTRDDLETMIELSD-KKRHEIKG------------------------------------------------------------------------------------------------------------------------------------------------------------------EKIRAFYGHS--IK-----------------DKLSK-----------------------TANKPP---KVLYHGTVQRFL-NQILQTG--LIPKERQYVHLSSDV------------------------STAKQVALRRDDRAIILEVAAQSAWE-N------------GVKFYIGNEDIWLSE-----------PIPSEYILSEPIPSE  177   Streptococcus sanguinis SK49                             bacteria>firmicutes
    125717421  287  3     SREISYILRHN--PLK-YNLT--LDKE-GWADIN--DL--LQKLNAR--------seWNGLSKKDLEKMIASSD-KKRHEIQS------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRAFYGHS--LK-----------------EKVQK-----------------------SPCQPP---NVLYHGTVEKFV-DSILEKG--LITKERQYVHLSTTP------------------------ETAIKVALRRDKKAIILKIDAQKAWD-S------------GIKFYLGNEDIWLSE-----------PIASKFISFEPIASK  179   Streptococcus sanguinis SK36                             bacteria>firmicutes
    227893699  291  14    SKKMSYCLRHN--PGK-YGLK--LDEY-GFVDLQ--EF--LNAMNRI-------hqhFPKLTEMKIREIMHNSD-KERFEIKN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKICALYGHS--LP-----------------GIIKR-----------------------KKAIPP---KVLYHGTAHRFL-TSIEREG--LLPMGRQYVHLSTDI------------------------AMAESVGKRRDHHPAILLVNAEKAHK-D------------GIDFYIGNDEVWLCD-----------CVPSKYLLCDCVPSK  184   Lactobacillus ultunensis DSM 16047                       bacteria>firmicutes
    298245737  293  2     SKTMAYVLRHD--PQS-HGLT--LDAE-GWVSLK--DL--LAALRQQ-------rsyWATLKEADLLAVLEQSE-KQRFEVRN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRAYYGHS--VP-----------------TKVEK-----------------------QPVTPP---EILYHGTTPQAA-NLIKGRG--LSPMKRQYVHLSADE------------------------ETAMVVARRRTNHPIILKVHARKAEA-N------------GVRFYLGNDMVWLAE-----------PIPSDYIQFEPIPSD  181   Ktedonobacter racemifer DSM 44963                        bacteria>chloroflexi
    226313333  296  6     RKRLLSILRQN--SEA-FQLY--YDTY-GYTPVE--PL--LEYLHTL--------kgCAYITRQDLHQVVEFDP-ERSIEWDGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------SLIRVTYGF---LP------------------SIAKs--------------------rlMEIVPP---DVLYYGTHRKLL-KQVLTGG--LLPIASEYVQLADRP---------------------------EHIGEPTDTLR-LVTVNAKEAHE-A------------GICFYRVGEHYCLSD-----------AVPSSYLQLDAVPSS  180   Brevibacillus brevis NBRC 100599                         bacteria>firmicutes
    312142649  297  5     SKTLSYILRHH--PES-FDLK--LAAD-ASVETD--EL--LNSLKNK----------FKKITKDDLIKVVEADP-KGRFSFLDEq----------------------------------------------------------------------------------------------------------------------------------------------------------------KRIRANYGHS--IE------------------GVNP---------------------eyEAVKPP---EFLYHGTTPEAK-NKILAEG--IKPMGRNYVHLSVNI------------------------KEAKKVAQRRTNNELIFKIRALKAYQ-A------------GQEFYKTAENIYLTD-----------QIAAKYLFFDQIAAK  179   Halanaerobium hydrogeniformans                           bacteria>firmicutes
    116748284  300  3     ARMLSYIGRHS--PGE-FGLY--WNPD-GTMPWK--EF--YWALQED--------eaLRFVRESHVREIALQGL-ELPFSLEN------------------------------------------------------------------------------------------------------------------------------------------------------------------NRLRLIGPAA--PP-------------------EYP-----------------------VSEFLP---GRLFYACRRAHL-EVIRLRG--LQASGRPYVLLCTER------------------------EQAVRIAKRREAEPIVIEIKAEEARA-A------------GTLFRKAGATVYLVE-----------CVAADHLVFPCVAAD  177   Syntrophobacter fumaroxidans MPOB                        bacteria>proteobacteria>deltaproteobacteria
    328952864  303  12    ARLLRYILCHH--PDE-FGLV--LDKS-GRLAVK--EL--LRALGQE--------egWRFVRRSHLEEVVNLIN-PGDFELDQ------------------------------------------------------------------------------------------------------------------------------------------------------------------TYIRALHPQP--AE----------LRSQ-------------------------------EAAWPP---PLLYRAITANSH-HAVAERG--LQPPSGGELVLADNQ------------------------ELAKRLGQRRDPQAIMVIVQAQAAAK-R------------GVNFFSYGPKLYLSD-----------AIAPEYLQLPAIAPE  183   Desulfobacca acetoxidans DSM 11109                       bacteria>proteobacteria>deltaproteobacteria
    301058276  304  1     --MLTYVLAYR--PDE-FGLI--PSEE-GFVRYK--EL--LKALHEE--------egWRHVRQSHINEMLMGED-RALFETEG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRIRSRKRHW--VM-----------DDQ-------------------------------SDHPLP---GLLYTSVRKRAH-PVAMEKG--LKAETGSHIALSPHR------------------------EMALRMGRRRDQHPVLLEIPAMLAEK-K------------G-MRIFSFGVLFLTP-----------EIPAHCISGPEIPAH  168   delta proteobacterium NaphS2                             bacteria>proteobacteria>deltaproteobacteria
    308270161  306  5     SKFVSYILERK--PDE-FGLV--PDEN-GYIKIK--SL--LLALNEE--------dgYKFVRRHHIDDILSSIP-DSQLEIND------------------------------------------------------------------------------------------------------------------------------------------------------------------DLIRSKYRDN--LP-----------KPT-------------------------------VSENPP---KLLYTCVRKKAY-SFALEKG--IFPVGNKKVVLSPAK------------------------EMAERMGKRFSPLPVVLTVNVQKALE-A------------GVIFHNSSE-LYTAD-----------AIPADCFTGPAIPAD  180   uncultured Desulfobacterium sp.                          bacteria>proteobacteria>deltaproteobacteria
    158521555  307  3     ARVIAYMLGQA--PAE-FGLV--PDAS-GYVKIK--EL--IKALHEE--------egWRHVRASMLNTLVLTLD-DVPFEIQD------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRTKDQTP--GA-----------PAE-------------------------------PVSGLP---KLLYTCVRQRAH-GRVAQAG--ITPSFAEAVVLSPDR------------------------EMAQRIGKRRDPDPVVLVVETRAALE-N------------GVAFRQTEGDLFLAD-----------FIPVDLFLADFIPVG  175   Desulfococcus oleovorans Hxd3                            bacteria>proteobacteria>deltaproteobacteria
    302344076  301  6     ARMLRYILGVC--PAE-LALL--PDAE-GWVRQK--DL--LAALHGE--------dgWKHVRQTMLTDMADRLA-SDVFEADD------------------------------------------------------------------------------------------------------------------------------------------------------------------TRIRCRQRSY--AP-------------------------------------------pnPEAKPP---AHLYYGARRRAY-PVIRERG--LDADDGPGLIVCADS------------------------QRALAIGRRRDAEPVLVTIQARLAQE-N------------GIQARLAQENGAALAAWGEEGLFVA-QWIDAQFLMGPPLPD  160   Desulfarculus baarsii DSM 2075                           bacteria>proteobacteria>deltaproteobacteria
    218780694  305  11    NKFLAYALGRR--PDE-FGLF--PDED-GWVKVK--DL--VRALSEE--------dgWKHVNKAHIKEVAYTLE-DPAIEYEHEe----------------------------------------------------------------------------------------------------------------------------------------------------------------GIVRAVEWDP--SL----------YYTG-------------------------------VPEDLP---KLLYVGARNKTY-PEIDKKG--IFPVGAPFVILCRDE------------------------DMAFRIGKRRDGNPIVLTVNTAMAQE-L------------GVVFAMAQELGVVFEQAGEVLLTAE-FIPKGCFTGPPLPKV  163   Desulfatibacillum alkenivorans AK-01                     bacteria>proteobacteria>deltaproteobacteria
    consensus  100  %     ........................................................................................................................................................................................................................................................p...............................................................................h...s..l.......l.h............................................h................................................................
    consensus  95   %     ...hs..LRH.........h........Ga.......h..h........................l..hh..s..K.Ra.h......................................................................................................................................................................lpA.bGHo............................................................hhaus....h...l...G..l....p..lHhs.................................u.b......hh.l........................h..s...l..s...........................
    consensus  90   %     .+.hs.hLRH...s.....l...hp...Gah.h....l..l....................p...l..hh..s..K.Ra.h.....................................................................................................................................................................bI+A.bGHo..h...................................................s.....hhHGT....h...I..pG..l....R..lHhs.s..............................su.R.....hhh.l....h................s..hb.s.p.lhLs...........................
    consensus  85   %     u+.hu.hLRH...s.....l...hp...Gah.l....l..l...................hs...l..ll.ps..K.Ra.h.....................................................................................................................................................................bIRA.bGHo..h...................................................s.....lhHGT..p.h...Ib.pG..l....RpalHhu.s..............................sG.R..s..hhl.lp...h................G..hh.u.s.lhLs...........................
    consensus  80   %     S+.lobhLRH...s....sl...hs...Gah.lp...l..l...................hsb..l..lV.pss.KpRa.hp....................................................................................................................................................................bIRA.bGHS..l............p......................................P.....lhHGT..p.h...Ib.pG..L....RpalHhu.s...........................s..sG.Rp.s..lll.lps..h................G..ha.u.s.VhLs...........................
    consensus  75   %     S+.lSblLRH...s.p.bslp..hc.p.Gah.lp..pl..l.....p.............hsb..lpplV.pss.KpRa.hp....................................................................................................................................................................bIRAsQGHS..l............p..h...................................P.....lhHGT..p.h...IbppG..L..bpRpalHhu.s...........................u..sG.Rp.sp.lll.lss..h...p............Gh.aabu.NsVhLsp............ls............
    consensus  70   %     SK.LShlLRH...s.p.hGlp..lc.p.Gahplp..pl..l...p.p.............hsbpplpplV.pss.KpRaphp....................................................................................................................................................................bIRAsQGHS..lp...........p..h.................................p.P.....lhHGT..p.h...IbppG..Lp.bpRpaVHhuss.........................p.u..sGbRp.spslllblcs.ph...s............Gh.FabupNsVhLsp............ls..hh........
    PDB:1wfxA  -    -     HHHHHHHHHH--------------------EEHH--HH--HHHHHHH--------------HHHHHHHHHHHH----EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEEE--------------------------------------------------------------EEEEE-------------------------EEEEEHH------------------------HHHHHHHH-----EEEEEEEHHHHHH-H---------------------EEEEE-----------------EEEEEEEE--

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Multiple Sequence Alignment of the NEURL4-like family

    ALIGN                                          -------EE---EEEEE------EEEEE-------------------------------------------------EEEE---HHH-----H-HHHHHH--------HHHEEEEEEE-------------------------------------------------------------EEE-----HHHHHH----
    HMM                                            --EE-EEEE---EEEEEE---EEEEEEEH-----------------EEEEE--------------------------EEEEEEEEEE--------EEEEE-------EEEEEEEEEEEE----EEEEE---------------------------------------------------EEEEE----EEEEEEEE-
    FREQ                                           --------E---EEEE------HEEEEHH-------------------------------------------------EEE-----H----------------------EEEEEEEEE------------------------------------------------------------EEEEE----HHHHHHHH--
    PSSM                                           ------------EEEE--------HHHHH------------------------------------------------EEEE----E-----------EE--------EEEEEEEEEEE-----EEEE---------------------------------------------------EEEEE------EE------
    FINAL                                          --------E---EEEEE------HHHHHH------------------------------------------------EEEE---EEE----------EEE-------EEEEEEEEEEE------EEE---------------------------------------------------EEEEE-----EEEEEEEE-
    NEURL4_Hsap_53829370                     1408  EAGTLTKKW---HMAYHGSNVAAVRRVLD-RGELGAGTASILSCRPLKGEPGVGFEEPGENCAPPREE------QPPPVLLSPSLQYAGAETLASKVQFRDPKSQRTHQAQVAFQVCVR--PGSYTPGP-------------------------------PSAALGEPPDPHFSPAE-LEWVTKEKGATLLCALLVR  1560  9606    Homo sapiens                        eukaryota>metazoa>chordata>vertebrata
    Neurl4_Mmus_29748106                      178  EAGTLTKKW---HMAYHGSSVAVVRRVLD-RGELGAGTTSILSCRPLKGEPGVGFEEPGENCAPPREE------QPPPVLLSPSLQYAGAEMLASKVQFRDPKSQRTHQAQVAFQVCVR--PGSYTPGP-------------------------------PSAALRELPDQHFSPSE-LEWVTKEKGATLLYALLVR   330  10090   Mus musculus                        eukaryota>metazoa>chordata>vertebrata
    GSTEN:00009647:G:001_Tnig_47211351       1132  EVSTALKKW---HIAYHGTGVGTLRRTLD-HSQLLPGTSSVFSVSPVKTEGPNDYGEPEENSAPGRE--------VPRVRLSPTMRYSGMETFAPKVKFQDPRSRRCHQAQVAFQVCIR--PGSYKVGA-------------------------------QSVGHSETLDPRFSNAE-IEWITKEQGGTLLYGLLIR  1282  99883   Tetraodon nigroviridis              eukaryota>metazoa>chordata>vertebrata>actinopterygii
    LOC581240_Spur_115948408                  208  LNVF--ESW---HVAYHGTSVGSVRKILD-RGTLLPPGDTSL-GRLYQPET-LGSS-LNKPSLVPD---------LMQIFVSPTLKYAGCDIFSHRCKFIDSLTQKEHFARVAFQVRIR--PGCYTAGP-------------------------------QSIGANHTIDPYIENSR-IEWTTKETSSIVLCALLIH   351  7668    Strongylocentrotus purpuratus       eukaryota>metazoa>echinodermata
    BRAFLDRAFT_74056_Bflo_260810360          1003  SQRNVFTDW---HRGYHGTPAGTVKKILQSSSQLLLPGDVT-----PGGEKMGPGKGKGFD--------------SVQVFLSPSIKYSGRDLYAKPMRIKDNTDGKEYTARVAFQVCIR--PGCYGIMHETV----------------------------GASRKGETIDPLFSNKE-LEWFTKERGVHALYGLLVK  1146  7739    Branchiostoma floridae              eukaryota>metazoa>chordata
    EHI_155600_Ehis_67480865                  253  GFGE--EEW-----AFHGSSIDSIQGIIK-EGFKLPD-DV---------DAVKLDS----------------GYFGHGIYLTYFSDYA--LFYSNS-----------RNSNQMVLCQIL--PGNVFKCKKRM----------------------------DGKKCQKGYDSHFSPKG-NEIVIFDPKHILPKYIIEF   371  294381  Entamoeba histolytica HM-1:IMSS     eukaryota>amoebozoa>entamoebidae
    BRAFLDRAFT_90934_Bflo_260831601           778  TALGVFQKW---HVAFHGTTVGALESILN-TGDLIKAGDKTMEGSRLSERDGHYKDSWKPE-----------GFDTKQVFVSPSIHYAGLPAYAKPSSFT--HRGTTYEAKVALQLYIK--PGSYKVA--------------------------------ASTVARKNVDKKFSDSE-IEWSTDRHGVIIVYGLLVK   922  7739    Branchiostoma floridae              eukaryota>metazoa>chordata
    cgd5_910_Cpar_66357730                    115  EEEN-VKNW---DLSYHGTTHKAIKSILK-DKRLVIPNNKTVHIRKGHI------------------------PNQYFIFTSPSLLYASFGLYSAPFKIKE----SKKWWQIVVEIVQK--PNSYVKEWE------------------------------TSGLGNYEFDKYIGNYE-LEWKSDQEMGNLIKAVLVR   245  353152  Cryptosporidium parvum Iowa II      eukaryota>alveolata>apicomplexa
    BBOV_III011060_Bbov_156089639              70  TYHP-INYI---GIGLHNNKEDTVDNETD-SGASMEPPDNVFSIPVITNDAT---------------------YFKQHIFASPSCMYATLPEMASALDFE----GLNVGLRIVIEVLVK--PASYVTGPA------------------------------SVKNIKNGFDCCFDNQN-IEWFVKNLDHIVPHRLLFR   203  484906  Babesia bovis T2Bo                  eukaryota>alveolata>apicomplexa
    Phum_PHUM397400_Phum_242016155           1565  TEKI--DTW---QVAFYGTRPDAIRRILD-HGELVLPCLLGMERTRVKAKEDETD--------------------SSHIVFSPSIKYAACDYFVTKFRFYDSRTKNKTEATLAFQILVQ--PGSYKVGPP------------------------------SVDVSKEIPDTRFERDA-TEWVTKERGATTLSALLIK  1702  121224  Pediculus humanus corporis          eukaryota>metazoa>hexapoda
    PTSG_01796_Ssp._326433251                 405  THARATKLWETSHVCYHGTSIGALKPIIE-GGEILPPGEVNVTHTHIIPRDDEDNPREGRLPTVYTTPAHNLDRIHKSVFVSPSVAYASSSTYAERYYW----PGGRQFLVPVLQTRIR--PDTYDVR--------------------------------SSTLRDTPHDPCYSADE-MEWYTPRRGVIQIYGLLLK   561  946362  Salpingoeca sp. ATCC 50818          eukaryota>choanoflagellida
    TP02_0033_Tpar_71029920                   104  NHFS--DNF---SIKHFLVKIIRSPRLSD-DDFSQLRNHINGASDPQSSVTKQSD--------PSHPDPNISNTIGEGLMVTPSCMYATKQEISSILTFEE----LDVKLQILIQIKAK--PGSYTVSP-------------------------------NSIKLNDNFDSCFPNSE-IEWYVKNVDDIIAERLLFK   248  333668  Theileria parva strain Muguga       eukaryota>alveolata>apicomplexa
    TA12305_Tann_84995898                     103  RHFT--DNF---SIKHFLLKIIRNPRLSD-DDFSKFRNYITGNSDLSSAVINNKD--------QPPADAATTDHKDEGLMITPSCMYATKPEISSILTFEE----LDVKLQILIQIKTK--PDSYTTSP-------------------------------NSITLNENFDSCFPNSE-IEWYVKNVDDIIAERLLFK   247  353154  Theileria annulata strain Ankara    eukaryota>alveolata>apicomplexa
    TRIADDRAFT_57456_Tadh_196007734          1231  NVNL--NEW---YIGYYPSTVGNVRQILD-NRILATGNEDDYDRDISVST--------------------------NICHIQEHVEI---SQF-RHEVF--------GLVSVAFEVYIK--PDATTIA----------------------------------------DIEGTGDQCSMLTFKHSPRNMILSALLIK  1341  10228   Trichoplax adhaerens                eukaryota>metazoa>placozoa
    SINV_00048_Sinv_322786335                1518  QSTT--DKW---HVAFYSIRLDAIRLILD-RGELMTK-EQLDVSNLTSGT-KSED-------------------QNPQVMFSPAVKYAASDEFTRKYPYIDMQLNKKLNASTAFQLLVR--PGSYTTFP------------------------------------KVFRDENERYCESVKWATKEAGATVIVALLVH  1649  13686   Solenopsis invicta                  eukaryota>metazoa>hexapoda
    LOC100117587_Nvit_345484523              1620  QSTT--DKW---HVAFYGTRIGTVRWILD-RGELLTK-EQLDTDSLTTGT-STED-------------------QNPQVVFSPNIKCASSEEFTKQYSYIDTQLNKKVNASTAFQLLVR--PGSYTTS--------------------------------------SKKDGLDSQLECIEWATKETGATVIIALLIH  1749  7425    Nasonia vitripennis                 eukaryota>metazoa>hexapoda
    EAI_14437_Hsal_307195422                 1616  QSTT--DKW---HVAFYGIRLDAIRLILD-RGELMTK-EQLDMSNLAMSI-KSED-------------------QNPQVSFSPSIKYAVSDEFTRKYPYIDTQSNKKLNVSTAFQLLVR--PGSYTISP-------------------------------------GDKDSIDLHCESCKWATKEAGATVIVALLVK  1745  610380  Harpegnathos saltator               eukaryota>metazoa>hexapoda
    blue_Amel_328784754                      1583  QNAI--DKW---HVAFYGIRLDAIRLILD-TGELIPK-EQLDLSNLTMNI-KMED-------------------QNPQVVFSPSIKYAASEEFTKKYPYIDTESNEKLNASTAFQLLVR--PGSYTINS-------------------------------------SSKDSDDSQFQSVKWATKEAGATVIMALLIR  1712  7460    Apis mellifera                      eukaryota>metazoa>hexapoda
    blue_Tcas_270008234                      1288  NTAT--DKW---HTAFYVCKVGAVRCILD-KGQPLTK-GQAQWCNLVAQ--KEDD---------------------VQVVFYPTLQNCKTSGYKTNN----------RVVHAAFQLLVK--PSAYSVSR-----------------------------------------------DPPEWSTKETGAIVLHSLLIQ  1395  7070    Tribolium castaneum                 eukaryota>metazoa>hexapoda
    blue_Dmel_78214301                       1604  VHFDLNGDW---LPFYYMTRVDKIRAILD-RGQPLPL-ETDPDEEPAAAA-LKDE-----------------PGTRLELYYSPNATVIEPVLPQHHFAS-EQ---GLHRISTSFEVYVR--RQSISGVTTGKAAAEAKRRSLGSTDHDHGGTGQGADGVGVTPSATLNESSVHLLND-LCWFTKEAGACIINALIIH  1769  7227    Drosophila melanogaster             eukaryota>metazoa>hexapoda
    AgaP_AGAP011965_Agam_158300710           1597  TADE--FVW---TTAYYNTRVDKIRSVLD-HGQPLPI-ETGQLLPE-SST-LNDN---------------FIPGTHILLRSVPDAAEPASNATSTSSHF--------FHIKTAFEVRVR--AQSLSAVDHSG-AGEGLNASTGGAGV--TGTGGCTSGVSTVPTA--GGVASGTDFTFRSWTTKEADACVLTALLIH  1754  180454  Anopheles gambiae str. PEST         eukaryota>metazoa>hexapoda
    DAPPUDRAFT_309455_Dpul_321459414         1336  PGIN--EKW---QTAYHQTRPCVVRRILD-EGHLLSP-DLNVWQRTKAAR-RSSK--------------GNDGESNGQLLFSPTLQ-PAS-LAPIAELY-DPILKKNQRGQVVLQVLVQ--PGSYKVRRATSPLNGPAPTVPTANTVGSVTCSPDPTHQQQLLNPPADTTAITDEDPAILWYTKERGAAIVQALLIS  1504  6669    Daphnia pulex                       eukaryota>metazoa>crustacea
    NEMVEDRAFT_v1g131035_Nvec_156360568       144  SQVP--REW---PVAYHGTNFTNANSILQ-KGLKPGD----------------------------------RALYGKGVYTSPSLQMV--EKYYAQEFKYE-----GKSYKIVFQSRVN--PDQSNGHL-------------------------------KIIPASKTGVGADYWLSPKQNVRKGPHDVRPYGILIK   260  45351   Nematostella vectensis              eukaryota>metazoa>cnidaria
    TTHERM_00581840_Tthe_118371452            890  DTSD--KTW---IVLFHGNKKLSTQELIE-EGYKQGG-------------------LQQYQGHQCRFG---RGLIKQGIYFYEKIQDA--EKHADTFFIND------KQYNLLFQCRVN--PKTVKSP----------------------------------------------INKPSCYVANDPKDVRPYRILIK  1002  5911    Tetrahymena thermophila             eukaryota>alveolata>ciliophora
    TTHERM_00621420_Tthe_118369526           1032  YNSK--EQW---IVLYHGTSIQGVEGITK-EGFRLGQ-------------------HHKYAGAKCRITGKIIEKSSKCVYLTDDANVA--GRYSTPFEI------KGKAYQMVFQCRVN--PKVVRSP------------------------------------------KEKPDYYIIEESGQPQQNIRPYRILLK  1151  5911    Tetrahymena thermophila             eukaryota>alveolata>ciliophora
    ubqP_Ddis_66808359                        209  CNGP--NEW---LVSYHGTKEESCNPIAM-EGYKLSS--------------------------------CSGFAFGVGIYSTPSIDIA--KTYGRTFKK-D-----NCHYVIVFQNRVN--PKTVIKI-----------------------------------------------DNIQYWISPNDADIRPYGVCIK   310  352472  Dictyostelium discoideum AX4        eukaryota>amoebozoa>mycetozoa>dictyosteliida
    ubqK_Ddis_66813768                        205  NNTD--GEW---PVSYHGTGKHESKSIAE-KGYDLSK--------------------------------GKRFLYGRGVYSTPSIKCA--EAYATSFIH-E-----GSTYRVVFQNRVN--PKTLIKIP------------------------------------------KSQTNFEEYWISPKDEDIRPYSICIK   311  352472  Dictyostelium discoideum AX4        eukaryota>amoebozoa>mycetozoa>dictyosteliida
    ubqM_Ddis_66813772                        165  NNVD--GEW---PVSYHGTGKHESKSIAE-KGYDLSK--------------------------------GKTFKFGYGIYSTPSIKCA--ETYANSFEY-E-----GCTYLVVLQNRVN--PKTLIKIP------------------------------------------KSQTNDEEYWVSPKDEDIRPYCICIK   271  352472  Dictyostelium discoideum AX4        eukaryota>amoebozoa>mycetozoa>dictyosteliida
    GSPATT00016112001_Ptet_145525701          190  NGNQ--NEW---RIMYHGTKQHFVSSIVK-TNLKPGSNN------SYCDQLCFDE-------------FNNQVKVGNGIYFSDKIEVCF--GYTNYTQI------GNKQFAVIFMSRVN--PREIRQ--------------------------------------------SKEMIAQRFFVINNSEDVRPYRILLH   307  412030  Paramecium tetraurelia strain d4-2  eukaryota>alveolata>ciliophora
    EDI_044520_Edis_167386548                 202  SNVT--GEW---AVSFHGSNCSKFTEIVQ-WGDKLGVSN----------------------------------VGGMSVFCTPDFRVA--LQHSDVVT--DP--QTGKKYKVIFQNRVK--PSSIIRA-------------------------------------------SKVGGPNNFWYITNPSDVRAYSICLF   307  370354  Entamoeba dispar SAW760             eukaryota>amoebozoa>entamoebidae
    EHI_013080_Ehis_67481957                  201  SNRD--EEW---PVSFHGSNCSKFTEIVQ-WGDKLGVSG----------------------------------VGGMAVFCTPDFRIA--LQHSDVVT--DP--QTGRKYKVIFQNRVR--RSSIIRA-------------------------------------------SNVGGPDNFWYITNPSDVRAYSICLF   306  294381  Entamoeba histolytica HM-1:IMSS     eukaryota>amoebozoa>entamoebidae
    ubqP_Ppal_281212323                       218  QSAP--GEW---IVSYHGTTTDEFGSMSN-DGYRISKSE--------------------------------KKDFNQGIYSTPSIKLA--ERFAQKFQF-D-----GAQYLVILQNRVN--PNTVEKL-----------------------------------------------GNGTYYLSPNENDVIPYGICIK   319  670386  Polysphondylium pallidum PN500      eukaryota>amoebozoa>mycetozoa>dictyosteliida
    GSPATT00020219001_Ptet_145536409          315  DGNK--DEW---RILFHGTKNENVNDIIV-SSLKEGWRS------LYEDDLCKDE-------------FGNNVPVGKGIYFSDKFTVCVDKGYAKPIQV------NNKSFSAIFMTRVN--PKKIRQS--------------------------------------------DRMKQERYFLVNRSADVRQYRVLIY   434  412030  Paramecium tetraurelia strain d4-2  eukaryota>alveolata>ciliophora
    LOC100206592_Hmag_221109790               223  TDVP--GEW---PVSYHGTGVNEAKSIAE-DGYNLTK--------------------------------GKRFAFGRGVYSTPNIKVA--EKYALNFMH------KNKQYAVVLQNRVN--PTTLLKIS------------------------------------------ADHTKIGEYWISPSDKDIRPYGVCIR   329  6085    Hydra magnipapillata                eukaryota>metazoa>cnidaria
    LOC100200953_Hmag_221109705               214  SNNP--GEW---PVSYHGTGVYQDKTFAM-NGYDLTK--------------------------------GKMFAFGRGVYSTPNIKVA--EKYAIKFLY------KNEHYAVILQNRVN--PTTLVKIS------------------------------------------ADRIGEGEYWISPSDKDIRPYGVCIR   320  6085    Hydra magnipapillata                eukaryota>metazoa>cnidaria
    DAPPUDRAFT_48503_Dpul_321472004            97  SSAE--DEW---PVSYHGTSYHNGLSIAS-EGFKLSK--------------------------------GTRFRHGKGIYSTPEIEVA----AQYAE---EATV-NGKTYKVVMQNRVN--PKNLEKV------------------------------------------DKAETGVGEYWISPSDEDIRPYGFCIR   203  6669    Daphnia pulex                       eukaryota>metazoa>crustacea
    LOC100639670_Aque_340383127               195  ESSK--GEW---PVSYNGTTKEGTMTIAA-KGYGEDK--------------------------------LARENFGRGFYSTPSVEIA--ADFARRFDHTD-----GKRYEAIIQNRVNLNPGHSEIIP-----------------------------------------VEKTRHGAEYYLTYSSDDLRPYGICIR   305  400682  Amphimedon queenslandica            eukaryota>metazoa
    LOC100639047_Aque_340386726               249  ESSK--GEW---PVSYHGTGREEAKGIAV-EGYD-SKRW------------------------------REKCYHGKGHYSTPDIEVA--AKYYTK-PF-D---QNGKKYEVVMQNRVNLSPGHTIIIP-----------------------------------------KEKTRAGAEYYLTYSSDDLRPYGICIR   360  400682  Amphimedon queenslandica            eukaryota>metazoa

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Multiple Sequence Alignment of polymorphic toxins

    134103275 ------------------------------RARV-AH-PDRLRGVSDEEISALLTYTYDHGSCYALNKSMREG-TPDREEMEP-YRRLLTSALNK--IRAN----DEAMG----V-PATQLVERKISVSPESMAGFREKYGNSGATVREEAFMSGTEVE---SRH--VPDGHREGEDYLVTMQVWNGTNVNIASLSR---LP-GEGEVLRIGDGEFRVARYEENGLKVNV--VLEEVGQ-----
    148546317 EKTVAAAPKKLMSLRDAVGKDMAERWIAEGRARADIRAPELSRLLSDDQIGALYGYSTNDV-YKAYNQALRE--GTATPGIKA-FAEHATEGLAR--LPRYL-GAETYRG-TD-L-PQHVLNRMQM-----------------GAVETDMAFFS---SS---ATT--PFSGN-------TQMVVRGVSGKDISFLTQ---I--PEAEVLYPPGTSFRVLNRIEQGPTTRL--LLEE--------
    157371257 -----------------------------ARANAEKNNAQLSTLLTDDQIGAIYGYTTNEG-YTALNPALRGQ-TPLTPELEA-FTGHVTDGLNK--LPAYN-G-ETYRG-TT-L-PAHILEQNQI-----------------GGTVSDGGFMS---TS---AKT--PFDGD-------VSISVRGNSGKQIDFLSK---YK-NEAEVLYPPNTRFEVINRIEQNGTTHLL-------------
    15893630  -----------------------------ANEWGSQYYDNWLKSLNDSERNAIRQYTGND--YKKINNYLRGV-NDSLDGIDPKIIEDIKSGLKKASVPHDM---KVYRG-TD-LNPLRNLIDVGK----DGSLDFSSLV---GKTFKDDGFMS-TALV---KES--SFDYM----N--VSWEINVPKGTEAAYVSKISYFP-DEAELLLNHGQEM-IIKEATVGSDGKLNIVLDLNLK-----
    167033761 --------------------------------------------LTDDQIGALHGYTTNEG-YQWINPALRGQ-TPLSPQMEA-FVTHANEGLAK--LPSYTLG-DTFRG-TT-L-PEDVMSRMQV-----------------GLPTSDAAFLS---TS---ADRALAFNGN-------VKMTLQGVTGKDISFLSG---H--REAEVLFGPGTRFNVVDRVDNGS------------------
    16802114  ------------------------------EKWGIDGFSVWRNSLSSREIQAIRDYTDIWH-YGNMNGYLRGSVEKLAPDNAE-RIKNLSSALEKAELPDNI---ILYRG----T-SSEILDNFLD----LKNLNYQNLV---GKTIEEKGFMS-TTTI---SNQ--TFSGN-------VTMKINAPKGSKGAYLAHFSETP-EEAEVLFNIGQKMLIKEVTELNGKIE--IIVDLL-------
    221200352 --------------KEKWGSKDVEDALA-----AKRGNAVLDKLLTDNEYLAIRGYTSNL--YEEINPALRAG---NPGEWGR-LTAEASNGLTK--LADN--G-YAHVG--------DVVRNLRL-----SNEQVEQLFPV-GGVFQDKAFLS-TTSD---LDG--VFPGK-------VTMNITSRSGVSVSSLSE---YP-REAEVLFKPDTPFKVLDRTHDPAKGSWNITLEE--------
    228992027 -----------------------------AHEWGSKHFDNWIESLTESERSAIRQYTGDD--YRKINNYLRGI-ADSLNDVESSVIDNIKSGLNKASVPYDI---QVYRG-TD-LKPFKNLYKIDD----EGKIVVDSLV---GKTVKDNGFVS-TAMV---KES--SFDHM----N--VSWEINVPKGANAAYVGKISYIP-TEAELLFNSGQEM-VIKSANVDSDGKIHLILDLI-------
    229007965 -----------------------------------------------------------------------------------------------------M---QVYRG-TD-IKPFKDLIELGK----DGRSDFESLI---NKTIKDDGFVS-TAIL---KAS--SFDYM----E--VSWEINVPKGASAAYVGKISQFS-NEAELLLNASHEM-IIKSVNVERNGKLHVTLDLILKK----
    255030176 ------------------------------EKWGIDGFSVWRNSLSSREIQAIRDYTDIWH-YGNMNGYLRGSVEKLAPDNAE-RIKNLSSALEKAELPDNI---ILYRG----T-SSEILDNFLD----LKNLNYQNLV---GKTIEEKGFMS-TTTI---SNQ--TFSGN-------VTMKINAPKGSKGAYLAHFSETP-EEAEVLFNIGQKMLIKEVTELNGKIE--IIVDLL-------
    291007932 --------------------------------RARVAHPDRLRGVSDEEISALLTYTYDHGSCYALNKSMREG-TPDREEMEP-YRRLLTSALNK--IRAN----DEAMG----V-PATQLVERKISVSPESMAGFREKYGNSGATVREEAFMSGTEVE---SRH--VPDGHREGEDYLVTMQVWNGTNVNIASLSR---LP-GEGEVLRIGDGEFRVARYEENGLKVN--VVLEEVGQ-----
    304399359 -------------------------------------------MLTDDQVGALYGYTTNEG-YTALNPALRGQ-TPLTPELEA-FAAHAKDGLSK--LPPNK-G-LSYRGINS-L-PEEILAKNQP-----------------GNIVSDGAFMS---TS---SNE--PFQGN-------ILIKVNGASGRDVAFLSE---YP-LEAEVLYPPDTQFKV--------------------------
    313625682 ------------------------------EKWGIDGFSVWRNSLSSREIQAIRDYTDIWH-YGNMNGYLRGSVEKLAPDNAE-RIKNLSSALEKAELPDNI---ILYRG----T-SSEILDNFLD----LKNLNYQNLV---GKTIEEKGFMS-TTTI---SNQ--TFSGN-------VTMKINAPKGSKGAYLAHFSETP-EEAEVLFNIGQKMLIKEVTELNGKIE--IIVDLL-------
    325518063 --------------KDKWGSKDVADALE-----AKRGNPVLDKLLTDNEYLAIRGYTSNL--YEEINPALRAG---NPGEWGR-LTTEASNGLTK--LADN--G-YAHVG--------DVVRNLRL-----TNEQVEQLFPV-GGVFQDKAFLS-TTSD---LDG--VFPGK-------VTMNISSRSGVSVSSLSE---YP-REAEVLFKPDTPFKVLDRTHDAANGSWNITLEEL-------
    354724236 --------------AEAVGKQRAENWISRGRELADNRDPALSALLSDEQVGALYGYTTDPG-YQMVNPALRGM-KPMTKEMEA-FTQHINDGLDQ--LPVYN-G-ETFRG-MNSL-PSNILEGYTP-----------------GKTVIDPAFVS---TD---INQ--GFSGP-------IQMRIEGVSGRKIDFLSE---FNATETEVLFKPNTTFEVISRSD---------------------
    358463913 -------------------------------------------SFTNAEAEGLRVYTSND--YTYINNYLRGFSDDLGPISTS-TISDIDSALSKMELPADL---TLYRG-TS---SAPFMNIVDK-NY-NGTLDWNSLV---GKTFEDRAFVS-TSVE---SKT--AFGGG-------VRWEINAPKGSKGGMVNTFSMFP-NENELLLPRNSKFLIKGIDKVDNNII--LKMDLI-------
    359410883 ----------------------------------GSKIIKSVSDLDKSQIEALIKYTGDD--YVNINNSLRGF-ETLSADNAE-AVDIMKSTLSNASLPEDM---ILYRG-TS-I---EELGSLKN-------LPPDELI---GKTFTQPSFLS-TSTENSVATG--TFSGN-------MQIEIEASQGAHGLDVSSISEYGSDEAEVLFNAGQKMFITDA-----------------------
    365970965 --------------------------------------KRLSSLLTDDEVGALYGYTTNEG-YPMVNNALRGQ-TELTPEIQA-FADHATNALDK--LPSYE-G-ITYRG-AT-L-PENVLMENQV-----------------GRVVSDPAFMS---TD---QKV--PFSGD-------TTIKINGKTGKPIDFLSE---YKGTETEVLFKPGTKFEVIERVDSGGKTAL--------------

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Multiple Sequence Alignment of the ARGA family

    RES             VIDKTVTLFRPVGQKEMELIRKSGYTSFPPRLPFQPIFYPVLSEEYAVQIARDWNTK-DAASGYIGYVTTFRVRANFLSLYPVQTVG---SSK-HQEY--WIPAEKLAEFNQNIIGLIEVIGKFR
    FINAL           ----EEEEEE---HHHHHHHHHH-------------------HHHHHHHHHHH------------EEEEEEEHHHHH-----EEEE---------EEE--E--HHHHHHHHHHH---EEEEEE--
    ALIGN           -----EEEE----HHHHHHHHH--------------------HHHHHHHHHHH------------EEEEEEEHHHHHH-----EE---------EEEE--E----HHHHH--HH--EEEEE----
    HMM             ----EEEEEE--HHHHHHHHHHH-------------EEEEEE-HHHHHHHHHHHE-E-------EEEEEEHHHHHHHH----EEEE---------EEE--EE-HHHHHHHHHH----EEEEEE--
    FREQ            ----EEEEE-----HHHHHHHH---------------------HHHHHHHHHHH-----------EEEEEEEHHHHH-----EEE---------EEEE----HHHHHHH--HHHH--EEEEEE--
    PSSM            -----EEEE----HHHHHHHHHH-------------------HHHHHHHH----------------EEEEE----H-------E----------------------HHHHHHH----HHHH----
    300869632       VIDKTVTLFRPVGQKEMELIRKSGYTSFPPRLPFQPIFYPVLSEEYAVQIARDWNTK-DAASGYIGYVTTFRVRANFLSLYPVQTVG---SSK-HQEY--WIPAEKLAEFNQNIIGLIEVIGKFR
    294817221       VQRATTTLWRPTGPAELELVRELDWRAWPPRLPEQPIFYPVLNEEYAVRIARDWNVR-HDG---AGFVTRFEVDTEFLRRYPVRQAG---GRT-ILEL--WVPADELDTFNAHIVGTIQVVREFH
    289770606       TESGTTTLWRPTGPEELALVEASGWTAWPPRLPEQPIFYPVLNEDYAVRIARDWNVP-ASG---SGHVTRFEADTAFLARYPVRRAG---GET-ILEL--WVPAEELAEFNRHIVGRIEVVREFH
    21222199        TESGTTTLWRPTGPEELALVEASGWTAWPPRLPEQPIFYPVLNEDYAVRIARDWNVP-ASG---SGHVTRFEADTAFLARYPVRRAG---GET-ILEL--WVPAEELTEFNRHIVGRIEVVREFH
    325917965       TAAATVTMHRPLRPEQDALVRVPGFRRWPPRLPEQPGFPPATDRRYAGEIASRWNVK-DSG---VGDVAQFAALAAFVDQYAMQTVG---GAH-HTEW--WIPAEDFDKFNAAIVGSITIIARFD
    297204161       TRSSTTTLWRPTGPKELDLVRELDWRAWPPRLPEQPIFYPVLDEDYAIKIARDWNVK-HDG---AGFVTRFEVESDFLSRYPVQQAG---GRT-ILEL--WVPAEELDEFNAHIVGPIEVVHEFR
    311900362       TQRSTTTLWRPTGPEELDLVRELDWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HSG---VGFVTRFEVETEFLSRYPVQQVG---GQT-ILEL--WVPAEELDEFNSHIIGRIQVVHEFR
    315504426       SSDVTTVLWRPLGQQELDLVREAEGRRWPPLSPEQTHFFPMLDEDFAVRAAQNWNLF-----GPVRYVARFHVETGFLGRYSTRSFG---GSA-APML--WVAADELDEFNAHIVGSIEVIHEFR
    304309800       SSATSVTLYRAVGPGQMRAIMERGFARFPARLPQQKFFYPMLTESFASFVATVWNVP-HSG---AGYVLRFRVAPEGIEGKRAFRVG---GPE-HREF--RIGREDFNRFNAAICGPIEVVAVFG
    328886920       SQQTTTTLWRPTGPKELDLVRELNYRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVESEFLSRYPVQQAG---GQT-ILEL--WVPAEELDDFNAHIVGEIQVVHEFR
    334120906       SDQETVTLFRAVGKKEMELIKESDFLAFPPRLSFQPTFYPVLHKAYAIQIARDWNTR-DAASGYFGYATRFRVAAEFLKNYPVQNVG---SSI-HQEY--WIPAEELAQFNQNIVGKIEIFAEYQ
    29826642        SRHGTTTLWRPTGPKELDLVRELKWRAWPARLLGQPFFYPVLNEDYAVKIARDWNVK-HDG---AGFVTRFEVESQFLRRYPVRQAG---GQT-ILEL--WVPAAELDDFNAHMAGEIEVVHEFR
    254383863       SRQATTILWRPTGPKELDLVRELNWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVETEFLSRYPVQQAG---GQT-ILEL--WVPAEELDEFNAHIVGEIQVVHEFR
    329935140       SQQATTTLWRPTGPRELDLVRDLNWRAWPPRLPGQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVESEFLSRYPVQQAG---GQT-ILEL--WVPAEELDDFNAHIVGEIQVVHEFR
    302869104       SSDVTTVLWRPLGQQELDLVREAGGRRWPLLSPEQTHFFPMLDEAFAVRAAQNWNLF-----GPVRYVARFHVETGFLGRYSTRSFG---GSA-APML--WVAADELDEFNAHIVGSIEVIHEFR
    239992555       SRQTATPLWRPTGPKELELVRELNWRAWPPRLPEQPIFYPVLNEDYAVRIARDWNVK-HDG---AGFVTRFEVESEFLSRYPVQQAG---GRT-ILEL--WVPAEELDDFNAHIVGEIQVVHEFR
    238061986       SDDGTTVLWRPTGPQELDLVRESGWCKWPPRLPDQPIFYPVLNEDYAVMIARDWNVP-ASG---VGYVTRFRVESEFLSRYPVRQAG---GKT-ILEL--WVPAEELDEFNAHIVGLIEVVHEFR
    320333489       PVGETVTLYRPVGEQELTLIADTDFRAFPPRLPDQPIFYPVLNFPYAEEIARDWNAR-HNTPP-VGYVTAFEVDARVATGYAIQIVG---REDRHQEL--WVPAEELGAFNAAIRGPIRVLAHHV
    160939744       PLGGKMILYRPVGSKELELIKKSNYRRFPPRLVEQPIFYPVLNEQYATEIASSWNVK-YN-EDHRGYVTKFEVDDQYCRQFEVHQVG---GPH-HKEL--WVPAEKLDEFNEHIIGEIHIISEFS
    149173583       NGKQTVTLFRPVGQQELDLIQASGWKEFPPRLYWQPIFYPVLTEEYAIMIARDWNTK-DPNSGYVGYVLQFDVEFDYLSRYEPQEAG---GRD-LKEY--WIPSEDLQEFNQHIMGTIDVIHEFR
    291301515       NPDGTTTLWRPTGPQELALVEQSGWRAWPPRLADQPIFYPVLNENYAVRIAREWNVP-ASG---SGFVTKFHIDTPYARTLPTQRAG---GNN-EREL--WVPAERLTEFNEHIVGTIEVTHRFS
    223935744       MNNETITLFRPVGPKELGLVREGGFKGFPPRLPEQPIFYPVTNEEYAVQIAQRWNVP-DSG---SGYVTRFQVRKEFLSKYDVKNVG---ASK-HNEY--WIPAEDLNEFNRNIVGEIEVIAEFH
    298246337       MQEETITLYRPTGPEELALIVESQCTAFPPRLFWQPIFYPVLFEEYAVQIARDWNAR-DGN---SGYVTRFRMRKAFLDRYEVQKVG---SAI-HQEY--WIPAEELDEFNRNIVGPIEVIAEYH
    302526847       MDTATTELWRPTGPAELELVRQSGWREWPPRLPEQPIFYPVLNEDYAVKIARDWNVR-YDG---AGYVTRFRVETAFLDRYPVRQAG---GET-ILEL--WVPAEELAEFNAHLVGEIEVVHEFR
    296446434       LGDDVMILWRPVGPRELELISASGMREFPPRLPEQPIFYPVTTEAYAIKIARDWNAP--RG---GGFVTRFQVRRSFISRYPIHIAG---GRE-NMEY--WIPAEDLVEFNGAIVGQIEIVAEFP
    332671633       IETDVVTLWRPTGPDELALVEASGWRRWPPRLPDQPIFYPVLNEDYAVRIARDWNVK-ASG---AGYVTKFDVRRGHLEEYDVQQVG---GET-ILEY--WIPAERLEELNDNIVGTIEVVRTFR
    186681810       GDRETITLFRPTGPKELALIKESGDSEFPPRLPEQPIFYPVLNEEYAAQIARNWNAA-STDTGYIGYVTRFQVRAEFLSRYSVKTVG---GSI-HQEY--WIPAEDLPEFNRNIVGLIEVIAEFR
    218679791       EDIETVTLWRPVGPEELALMRDLDMRGFPPRLPDQPIFYPVLSEDYAVKIARDWNVP-RSG---SGFVTRFEVRKDYLNTYAVQEAG---GRA-HLEY--WIPAEEMDRFNAAIVGTIEVMQTFP
    330469448       DDVNTTVLWRPTGPRERELVRASGWRAWPPRLPDQPIFYPVLNEDYAIKIARDWNVP-ASG---AGYVTRFHVETDFLSRYPVRQVG---GDT-ILEL--WVPAEELDEFNSHIVGQIEVVHEFG
    302553253       DRRTTTTLWRPTGPKELDLVRELDWRAWPPRLPEQPIFYPVLNEDYAVRIARDWNVK-HDG---AGFVTRFEVDSDFLRRYPVQQAG---GET-ILEL--WVPAEELDEFNAHIVGRIELVHEFH
    297192271       ATTPTTTLWRPTGPEELELVRKSGWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVESEFVARYPVQQAG---GRT-ILEL--WVPAEELDEFNAHIVGEIQVVHEFR
    171913882       APKPTVTLYRPVGPAELELISASAWKRFPPRLPDQPIFYPVLNEVYAAQIARDWNVA-ASG---SGHVLKFEIDAVYISRFDRQVVG---GSQ-HEEL--WVPAEELEEFNDHIVGTIEVVANYG
    302866493       -MTETTTLWRPTGPRELDLVRASGWRAWPPRLPDQPIFYPVLNEQYAVMIARDWNVP-ASG---AGYVTRFHVERAFAARYPVRQVG---GRD-ILEL--WVPAEELDEFNRHLVGPIEVVHEFR
    318058555       --MRTTTLWRPTGPAELALVRASGMRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGYVTRFAVAADFLARYPVRQAG---GET-ILEL--WVPAEELPEFNVHLVGPIEVVREFH
    145596643       -MAETMTLWRPTGPEELDLVRASGWKAWPPRLPDQSIFYPVLNEQYAIMIARDWNVP-ASG---VGYVTRFDADRD---SRPVTRSGRQAGAT-SLSCGCWPRIS--TKFNQHIVGQIEVVHEFR
    159038599       -MAETTILWRPTGPEELELVRASGWKAWPPRLPDQPIFYPVLNEQYAIMIARDWNVS-ASG---VGYVTRFEVDREFASRYPIRQAG---GRD-ILEL--WVPAEELDEFNRYLVGLIEVVHEFR
    182412866       -MTKTTTLYRPVGPKELALIEASGFRSFPPRLPDQPIFYPVTNEDYAIQIARDWNVP-ASG---SGFVTRFQVESDFLKQYPPRVVG---SKV-HEEL--WIPAEALDEFNRHIIGLIEVTHRFG
    297561422       -MPATLTLWRPTGPAELALVGDSGWREWPPRLPEQPIFYPVLNEDYAVRIAREWNLP-RDG---EGHVTRFRVDADFASRYPVRQAG---GRT-ILEL--WVPAGELAAFNAHLVGPIELVRSFL
    145595385       -MAETTILWRPTGPEELELVRASGWKAWPPRLPDQPIFYPVLNEQYAIMIARDWNVP-ASG---VGYVTRFEVDRAFASRYPVRQAG---GRD-ILEL--WVPAEELDEFNRHIVGLIEVVHEFR
    239626468       -----MILYRPVGTKELELIKKSNYRSFPPRLPEQPIFYPVLNEQYATEIASGWNVK-YN-DDHKGYVTKFEVDDSYCGQFEVHQVG---GAH-HKEL--WVPAEKLEEFNEHIVGEIQIISEFS
    163754443       ----MKTLYRPIGEKELILIAESNFTKFPPRLEWQPIFYPVLNEEYAVEIASKWNTK-DEFGNYLGFVTEFEITEEEFNKYKTENVG---SAH-HNEF--WVPAEKLEEFNNAIIGRIKVIKVFI
    124007251       -----MKLYRPVGLKELELILAANAKAYPPRLQWQPIFYPVLNFEYARQIATRWNLD-DELSGYAGFVTAFDINDAYIAQFEVQNVG---AHL-HNEL--WIPAESLAEFNTHIHGYIQVLAAYY
    284038124       ---MTTTLFRPVSKKELDLIEQSNWTKFPPRLHEQPIFYPVTNIEYARQITIEWNVP-AYG---NGYVTQFEVDSEYLKKYNVENVG---GSI-HNEL--WVPAEELDEFNSQIVGPIKVVESYE
    159901068       -----MILYRPVGLEELTLIAQAGYRSFPAQLAEPPIAYPILNLEYASHVAESVKTK-DAEAGYAGFVAEFEISEQYARQFAVKSVG-I-RRR-HREL--LVPIEEFHNFNTRILGHIKVIASFY
    256420608       --MNTTILYRPTGIKELALIAATDFKHFPPRLSWQPIFYPVLNQPYAEQIALEWNTN-DEASGYCGIVTRFAVDAAFLERYDIQNVG---DGS-HNEL--WVPAEELEMFNQHITGKIEVVKTFL
    83649603        --MKTVTLFRPTGPNELALVEESGFKRWPPRLSEQPIFYPVCNEDYARQIARDWNVK-DSG---VGYVTRFAVDADYLSRFDVKVVG---GRE-HAEY--WIPAEQLEEFNDHIIGGIEVIATYR
    296130683       --MSTRTLWRPTGPEELALVEASGRRAWPPRLPDQPIFYPVLNEDYATRIARDWNVK-ASG---VGYVTRFEVATEFLDRYDVQQAG---GET-ILEY--WIPAEDLDELNAHIVGTIEVVAEYR
    225390142       -----MILYRPVGKRELELIEQSGYRAFPPRLPEQPIFYPVLNQRYAQEIAGRWNTR-DARSGYRGYVTRFEVEDRYISRFESHVVG---ASW-HEEF--WIPAGELEEFNRHILGRIEVVKTFG
    256376037       --MDDVVLWRPTGQAELDLVAGSGWREWPPRLPEQPIFYPVVNREYATRIAREWNASGAEG---VGYVTRFAVEGEFLAKYPVQSAG---GSG-IDEH--WVPAEELEEFNRHVVGRIEVEAEYR
    333985238       -----MILYRPVGHNELALIVESGLKGFPPRLPDQPIFYPVLNAGYAKQIALEWNTK--S-DTFSGYVTRFNIDNDYAQKFNREIVG---GKV-HEEL--WVPSEELSEFNQKIVGHIEIISAYF
    338532263       -MSNPLTLYRPVGLKEAELILDSGCSAFPPRLPDQPIFYPVMNAEYARQIARDWNTP-DAGSGYAGFVTAFGVDADYASRFPVRTVG---NSL-HQEL--WVPAEDLATFNQHIQGPVRFTEAWY
    303241812       -----MKLYRPVGISELELIKQSGMTKFPPRLPDQPIFYPVLNRKYACQIAREWNTK-SA-PGYAGFVTEFDVDDDYISKFEVKTVG---AFV-HTEL--WIPAEELDEFNRHIIGEIKVIESYY
    269118724       -----MKLYRPVGLQELEKILNFGSEKFPDRQVWQPILYIVENYGYAEQISTMWNLK-DENSGFSGYILEFTISDDYMKNYDIKQVG---DKT-HLEY--WIPAEDTKKFNNSLTSKIKIINAFY
    108763108       -MPNTRALYRSVGLKEAELFLVSGCSAFLAPTARPAHLLPGDERRVRTANCRDWNTP-DAGSGHAGFVTAFDVGADYASRFPVRTVG---NSR-HQEL--WVPAEELATFNQHIQGPVRFTEAWY
    16126106        --MTSVTLYQPVGLEELQAIKASDWRAFPPHDIEQPVFRPVTSEAFAAQLARDWNAA-HTTYR-RGYVVQFAVSKTFLDAYENKVSG---TPG-HEEY--WIPSEDLSLLNAAIQGQIAVAGTFA
    162453007       -----MILYRPVGLAELRLIAEAGYRAFPPRLSHQPIFYPVLTEEYARKIARDWNTA-DETSGFAGWVTRFEVEDDFARRYPVQIAG---GRS-HEEL--WVPAEELEEFNRHLVGTIEITEVYC
    126740444       -----MKLFRPTGLKELVLVRDSGWASWPPRLPDQPIFYPVTTFGYAEKIARDWNSV-LPAPDNMGFVTEFTISEAAARRYPVEEAG---GRE-HREL--WVPAEELEWFNGELTSTIRIVSAYR
    300774507       --MKTTTLYRPVGEKEMILIMESGFKSFPPRLEWQPIFYPVLNEEYASEIAEKWNTR-DEAGNYLGFVTQFEVLEEVADQYPTQNVG---ARN-HNEL--WVPSEELNSFNKAIIGDIKYR----
    consensus/100%  .......habs....b...h.......a.........h.......h....s..hp............h..F.h.......b.....G.............b........hN..h.u.l.h.....
    consensus/95%   .......LaRs.G..Eh.hl.......aPsb...Qs.hhPh.pb.aA.bhu..WN..........GaV..F.h....h..h..p.sG...s.....bh..Wls..ph..hN..l.G.Iph...a.
    consensus/90%   .......LaRPsG..Eh.Ll...shp.aPsRL..QPhFYPl.sb.YA.blAppWNs.........GaVspF.l...hh.pa..p.sG...s.....Eh..WlPu-ch.pFN..l.G.Ipl...a.
    consensus/85%   .......LaRPsG.pEL.Ll...shp.aPPRLs.QPIFYPV.sb.YA.bIApcWNs.........GaVspFplp..ah.pa.sp.sG...u.....Eh..WlPAEcL.pFN..lhG.Iplh..a.
    consensus/80%   ....s..LaRPsG.pEL.Llb..shp.aPPRLspQPIFYPVlscpYA.bIApcWNs...ss...sGaVTcFplp..ahppassppsG...up....Eh..WlPAE-L.cFN.pIlG.Icll.pa.
    consensus/75%   ....s..LaRPsG.pEL.Llb.ssac.aPPRLs-QPIFYPVLscpYA.bIAc-WNs...ss...sGaVTcFcVc..ahppYslppsG...up...bEh..WlPAE-LscFN.pIlG.IcVl.pa.
    consensus/70%   ....o.sLaRPsG.pEL.Llb.usa+.aPPRLP-QPIFYPVLNEpYA.bIAR-WNs...su...sGaVT+FcVcspahs+YslppsG...Gpp..bEh..WlPAE-Ls-FN.cIlG.IcVlppF.

    #==== Truncated members
    126740444       -----MKLFRPTGLKELVLVRDSGWASWPPRLPDQPIFYPVTTFGYAEKIARDWNSV-LPAPDNMGFVTEFTISEAAARRYPVEEAG---GRE-HREL--WVPAEELEWFNGELTSTIRIVSAYR
    119477262       -----------MSPAQLAAVVASDWRQFLQEAPQQTIFYPKMYVGYAEQIAKQWNAR-QYS---AGYVVGFTMPGTFMDRYETQTIA---YEE-HRDY--KLPVAELDVFNSHIQGRIRVAAAFA
    148256740       ------------------MIAASGMRAFPPRLPEQPIFYPVLTEAYAVKIARDWNVP-ASG---SGHVLRFEVLRTFVDRYEVREAG---GRD-HLEY--WIPSEHLAEFNAAIVGPIVLVKTFP
    146341856       ------------------MIQATGMRAFPPRLPEQPIFYPVLTEDYAVKIARDWNVP-ASG---SGHVLRFQVRREFIDRYEVREAG---GRD-HREY--WIPSEDLAEFNAAIVGTIALVKSFP
    330467180       -------------------MEASGWREWPPRLPDQPIFYPVLNRWYATKIAREWNVP-AGG---VGYVTRFEVQREYMDRYEVHQVG---GRD-VLEY--WIPAEELADFNAHLVGAITEEADYR
    290960596       --------------MELDLVRESGWRAWPPRLPEQPIFYPVLDEAYAVQIARDWNVK-HDG---AGFVTRFEVDAGFLRRYPVRQAG---GRT-ILEL--WVPAEELEEFNAHIVGAIEVVHEFR
    94971452        ----------------------------------------MLTIEYARQIARDWNTR-HERSGYAGYVLRFAVDTDFLSRYEIQRAG---SDA-HLEY--WIPAEEMEEFSVHIVGDIEVLEQYT
    239626503       -----------------------------------------MNKQYAIEIASGWNVK-YN-EDHRGYVTKFEVDDQYCRQFEVHQVG---GAQ-HKEL--WVPAEKLDEFNEHIIGEIHIIKEFP
    312888451       -----------------------------------------MNEEYAIQIARDWNVP-AWG---SGFVTRFAVSSSYLKKFEVQNVG---GVI-HNEL--WVPAEELEEFNDHIIGLIEVTKTFL
    282864000       -------------------------------------------------------MK-HNG---VGYVTRFEVGSDFLVRHPLQQDD---GRT-IPEL--RVPAEEPDDLDAQSAGDIRVVHKSR
    13470985        ------------------------------------------------------------------------MLKSFLDRYRVEHAG---SKA-HLEY--WIPAEDLDDFNKAIVGKIEVTATFG
    158333527       -----------------------------------------------------------------------------MDNYDIQKVG---GAH-HTEW--WIPAEKLEELNDNIVGEIEVIGEYR
    289663132       -------------------------------MPEQPIFYPVTNQRYAEEIASRWNVK-DSG---LGYVAQFEVSAAFVEHDAIQNVG---GAH-HTEW--WIPAEELDALNDTIAGLNDIIGQFD
    13470984        EAQPTITLWRPIGPEELKLIEASNMRAFPPRLPEQPIFYPVLSEAYAVQIARDWNVP-ASG---AGFVTGLPC----------------------------------------------------
    329184512       AMKDVVCLYRPVGEAELQLIAAAVFKAFPPRLPEQPIFYPVLNFEYAAQIARNWNTK-DKNSGRAPRRSV-------------------------------------------------------
    310818708       --METVTLWRPVGPEELALIREADMRAFPPRLPEQPIFYPVTTRDYAVKIARDWNVP-ASG---SGFVTQFEVRKDFLDHYEVQEAG---GQA-HRE----------------------------
    153873366       ME--TITLFRPIGQTEMDLIVQSDYLAFPPRLPFQPIFYPVLQEDYAVQIHEIGILMMRLRAMLAM-----------------------------------------------------------
    315502903       TE--TTTLWRPTGPRELDLVRASGWRAWPPRLPDQPV----------------------------------------------------------------------------------------

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Multiple Sequence Alignment of the NUE family

    ALIGN           --------------HHHHHE-E-----EEEEEE----HHHHHHHHH----------------EE----HHHHHHH----------HHHHHHHHHHH--HHHHHHHHH-------------------------------------------------------------HHHHHHH------EEEE-------------H----HHHHH-----HHHH-HHH--EE--EEEE---HHHHHH-HH-HHH--------------------------------------HH-HHH-------------
    HMM             ---------------EEEEE-EE----EEEEEEE---HHHHHHHHH------------E--EEEE--HHHHHHHHH---------HEEEEHHHHHHHHHHHHHHH--------------------------------------------------------------HHHHHHHH------EEEEE---H-------------EEEEEE---HHHHH-HHHHHHH--EHHHHHHHHHHHH-HH-HHH-------------------------EE----E----HHHH-HHH-------------
    FREQ            --------------HHHHHH-H-----EEEEEEH--HHHHHHHHHH----------------EE--HHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------HHHHHHHH------EEE------------HHH----HHHHHH---HHHHH-HHH--EE--EEEE---HHHHHH-HH-HHH---HH------------------HH------------HHH-HHHHH-----------
    PSSM            ---------------EEEEE-EE-----EEEEE----H-HHHHHHH---------------EEEEE--HHHHHHH-----------EEEEEEEE-HHHHHHHHHH---------------------------------------------------------------HHHHHHH------EEEEE-----------------EEEEE----HHHHH-HH----E--EEE----HHHHHH-HH-HH--------------------------------------HHH-HH--------------
    FINAL           ---------------EEEEE-EE----EEEEEEE--HHHHHHHHHH---------------EEEE--HHHHHHHH-----------EEEEHHHHHHHHHHHHHHH--------------------------------------------------------------HHHHHHHH------EEEEE------------E----EEEEEE---HHHHH-HHH---E--EEEE---HHHHHH-HH-HHH------------------------------------HHHH-HHHH------------
    294781860       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNDKIADEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVKNSVISSYKPNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIHGKLIGR----RSIQLGIR-GEAVE-KYVNEWI--VKITDITDDVKRI-KK-VLIMELLK----------------------------------------------------
    256422007       ------------MKEKTIRA-LYDE-ESITVYQAYNGLIAKRAVEAQTF-TTPPFRRDR--MTWIKPSFCWMMYRSGW-ATK-EDQEYILAIKIKRSGFEWALQNAVLSKFDHKIHS-------------------------------------------------TTNEWNRLLKAS--PVRVQWDPERDIYLQPTDQ----RALQIGIS-GTAVD-QYISEWI--IGIEDITAYSQHI-GQ-LVKVRKIE----------------EAMALLPQERPY-PLPV-------------------
    300789763       MFE------EQRVPDRQVRA-AQTE-TTVRVYQACSPAVADAALEEQTF--------ERGGTVQLTPSFRLAAYGSEN-GRK-PGHERILAIDLTRDGFEQALTHS----------------------------------------------------------------------------HVEWEAERDLDHTALNF----QAIRIGLD-S-----APADEWI--TAITDVTPVVRDI-AG-LLATDQLH----------------LAVKLVPHEPPY-ELG--------------------
    228473982       MK-------DITQEERKIYA-LYDN-NTIRVYQAYNAEIAEEALKLGTF-GSH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVRKSVLSSYKADLGI-------------------------------------------------TEEQWKEDVKNS--LVRCQWDPERDIYGKPIGR----RSIQLGIR-GAFVE-KYVNDWI--VKITDITEEVKRI-KQ-HIDKGTFT------------------KDLLPKEQEY-IIP--------------------
    257125945       ---------MKKGEERNIYA-VFDD-KTIRVYQAYNNEIADEALKLGKF-GSK-FSLTR--MTWIKPSFLWMMYRSGW-ASK-QGQERILAIDLKREGFDEIVKNSVLSSFREVSDL-------------------------------------------------SKEEWKNKLDNS--EVRCQWDPDRDIYGNPLGR----RAIQLGIK-GETVK-KYVNDWI--VNITDITDKVVEI-RN-SIQNGTFS------------------ESMLPKEIKY-I----------------------
    254302431       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNNVIAGEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVKNSVISSYKTNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIYGKPIGR----RSIQLGIR-GEAVV-KYINEWI--VKITDITDEVKRI-KQ-SIDNGTFK------------------ESFLPEEKEY-IVK--------------------
    336250841       MEKHLP---KYSIPERQIRA-FFTK-DFIRVYQAYSDEIADSAIKNNTF-VSPPFSLTR--MTWIKPSFLWMMYRSGW-GKKDSNQTRILAIDLSHDAFQKILHLGVPSDYHSASTF------------------------------------------------QNKEEWQDKIKNS--DIIFQWDPERDIHLNKLNY----RTIQIGIR-NQAVI-NFCNEWI--VNLHDITHQVQEI-HN-LVSLGDFC----------------KAKTLIPTEKTY-HFQL-------------------
    260889576       ---------MKKEEERNIYA-VFDD-KTIRVYQAYNNEIADEALKLGKF-GSK-FSLNR--MTWIKPSFLWMMYRSGW-ATK-QGQERILAIDLKREGFDEIVKNAVLSSFREVSDL-------------------------------------------------SKEEWKNKLENS--EVRCQWDPDRDIYGNPIGR----RAIQLGIK-GETVK-KYVNEWI--VNITDITDKVIEM-RE-KIENGSFL------------------DSNLPIEEKY--V---------------------
    256374811       ------------MESRQIRA-DFDE-RTLVVYQAYSPEIAEPALAAGTF-VPP-FKPGR--MTWVKPSFLWMAYRCGW-ARK-AGQERVLAVRVLREPFDAAVLAAVPSREVVEGKP---------------------------------------------------------------EIRVQWDPERGLRHEALGH----RSLQLGLA-GGASR-RYVEEWI--TGLTDVTGLMTRV-GA-AVAAGELE----------------LARELLPVERAY-PLEV-------------------
    226327538       MNDD-----RVDCPECEVRA-YYTN-DFVRVYQAYSNTIAQSAVANGTF-VSPPFSMTR--MTWVKPSFLWMMYRSGW-GRKDANQASILAVDITHEGFQEMLTQGVVSHFDPDRYV-------------------------------------------------SAEAWKAASETS--NIRIQWDPERDIYLNRLSY----RTIQIGLR-NQAVE-KYCQEWI--VNITDITDKARKI-DN-CIANGDLD----------------TAYSLLPVEKPY-HFGE-------------------
    197286762       MNDD-----RVDCPECQVRA-YYTD-DFVRVYQAYSTTIAQSAVANGTF-VSPPFSMTR--MTWVKPSFLWMMYRSGW-GRKDPNQASILAVDITHEGFQQMLTQGVVSHFDPDHYV-------------------------------------------------SAKEWQEATETS--DIRIQWDPERDIYLNRLSY----RTIQIGLR-NQAVE-KYCNEWI--VNITDITDKVRKI-DT-CITNGDLD----------------TAYSLLPIEQPY-HFAK-------------------
    262067268       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNDKIADEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVKNSVISSYKPNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIHGKPIGR----RSIQLGIR-GEAVG-KYVNEWI--VKITDITDDVKRI-KK-SIDNGTFK------------------ENLLPEEKEY-IIK--------------------
    340754465       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNNVIADEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKRAAFDEIVKNSVISSYKPNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIYGKPIGR----RSIQLGIR-GEAVE-KYVNEWI--VKITDITDEVKRI-KK-SIDNGTFK------------------ENLLPEEKEY-IIK--------------------
    167588668       MKSHLKQT-PEAIPLRQIRA-MYDD-RTIRVYQAYSDAIADSALTHGTF-VSPPFKTER--MTWIKLSFLWMMYRSGW-GLKDSGQARILAIDISREGFEWALAHSCLSHPDESMHR---------------------------------------------------DEWQRMKEKA--PVRIQWDPERDLLLQPLAY----RAIQVGLS-KQAVD-LYVHEWI--QRITDVTPLAHSL-HA-LVGQGDFE----------------SAQALLPLEQPY-CIGA-------------------
    191169136       -----------MADYFEIRA-DYNQ-HTITIYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQHILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGIWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSEAA-RKALG--MK-------
    345368115       -----------MADYFEIRA-DYNQ-HTITVYQAYNDAIADVAVRNGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQRILAIRIKRTFFDTLLEQSVLTTPEAHVYP-------------------------------------------------HAGIWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSAAA-RKALG--MK-------
    193070962       -----------MADYFEIRA-DYNQ-HTITIYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQHILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGIWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSAAA-RKALG--MK-------
    312199543       VDRRP----ADGAGMREVLA-SHTA-ATLTVYQAYSPAIAGPALRAGTF-VEP-FRVGR--MTWVKPSFLWMMYRCGW-ATK-PDQERVLAVEIGRDDLLWALARACLSSFEPGQHA-------------------------------------------------DPRSWRAALAAA--PVRVQWDPDRDLYLRPTGR----RAIQIGLG-PEASR-HYVSSWI--RSIRDVTPLAREI-HA-RVQADDLD----------------GARALLPEEHPLALPSEIA-RRLGA--SP-------
    218547498       -----------MADYFEIRA-DYNQ-HTITVYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQRILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGVWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSAAA-RKALG--MK-------
    170684105       -----------MADYFEIRA-DYNQ-HTITVYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQRILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGVWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSATA-RKAWG--MK-------
    311896751       ---------MTETPKRQVRA-RYDE-ETVTVYQAFRPEIAEPAVAGGRF-PAA-FDPGR--MTWVKPSFRWLMHRSDW-ARS-EGQQRVLGVVLWRAGFDAALEAAVLSSYERGVHA-------------------------------------------------SRAEWQRELRRS--EGRAQWDPERDLELRPLAH----RSLQLGLS-GSLVE-RYLGEWL--VRIDDLTPLARAL-HA-TRDP-----------------------GLLPPERPY-PLPAGA-AVRLG--AS-------
    255930929       ---------MTSTTYRAIRA-KQTP-TTVTVYQAYPPEIADPALEAHTF-VPP-FSRDR--MTWIKPSFLWMAYRSGW-ATK-PRQERVLAIEISREGFEWALRNCCLSHYSPSEET-------------------------------------------------SQEKWRKRLRAS--PVRVQWDPERDLSLRSLDY----RSIQIGLS-GEAVR-RYIDEWI--VSIADVTHTMKQI-DG-YLKDGDVD----------------AARSDLPEERPY-ILPEDL-QENLR--MK-------
    163754444       ITQNN----EWPQNGHHIMA-QYDD-EKIIVYQSYRPAIGLFAAENQFF-GGP-FSLER--MTWIKPNFLWMMYRNGW-GTK-VGQEVVLAIHLKREAFQKYLENAVHSSFKPELYE-------------------------------------------------SQEMWKEAVKSS--NVRLQWDPDHDPYGAKLER----RAIQIGIR-NEFIR-SYAKEDI--LEIENISEFVAEQ-YE-FVKSNQLE------------------KLMIPAERPFLPEGDEL-RKKLQ--LQ-------
    239987775       MNT------PPVPPRHEIRA-LHTA-TTVTVYQAYRPAIGLPAARDGRF-PAE-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQEVVLAVEIDRSGLEWALANAELSHYVRDVHP-------------------------------------------------DQATWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEASR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVQVDDLAA-------
    291444753       MNT------PPVPPRHEIRA-LHTA-TTVTVYQAYRPAIGLPAARDGRF-PAE-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQEVVLAVEIDRSGLEWALANAELSHYVRDVHP-------------------------------------------------DQATWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEASR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVQVDDLAA-------
    124002565       ---------MKQKNKYEIRA-LYTP-KHIALYAAFSSSIANVALKSQQL-LPP-FSYDR--MTWVKPSYLWMMYRSDW-AQK-DNMQRILRIWIKRIDWELALKEAILTTPEAHVYN-------------------------------------------------DAKKWRKQLDKA--RVRVQWDPERDIQNKHLSF----KSIQVGIM-PSLAE-TYAKKWI--AKIEDVTPLTQHI-RS-LVVAQQFE----------------QATQLLPKEQAY-PVEAEL-KRILG--IG-------
    110639136       ------------MLEKQIRA-VYDQ-QTITVYQAYKNEIAIPAVKNQKF-VAP-FKIER--MTWIKPSFLWMMYRSGW-AAK-EGQEHVLAIKLKREGFEWALANCCLSHFDSTMFS-------------------------------------------------SLEAWKNKLEHT--QVRLQWDPEKDIHLQNLAY----RSIQIGLS-GVAVE-HYVNDWI--VSIDDITPVCKKI-HA-LVLDKKTE----------------EANSLLPAENIY-PVSETL-KHTIG--AD-------
    344999740       MNV------QATPPRYEIRA-QHTA-ATVTVYQAYRPAIGLPAARDGRF-PAA-WKRDR--MTWVKPSFLWMMYRCGW-GAK-EGQEVVLAVEVERAGLAWALANAELSHYVRGVHP-------------------------------------------------DEAAWKQALRSA--PARVQWDPERDLNLNPLPY----RSLQLGLS-GEAAR-RYADEWT--VSIRDVTPLARDV-HA-LVRAGDRD----------------RAASLLPTETPL-HLPAPR-PL--------------
    326779281       MNT------QALPPRYEIRA-RQSA-TTVTVYQAYRPAIGLPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EEQEVVLAVEIDRGGLEWALAHAELSHYAAEVHP-------------------------------------------------DQAFWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEAAR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVRA---AS-------
    124004042       KDYET----DLPQEGRHILG-QMTNAENLIVYQAFNPSIAKYAVTHQQF-GGSQYSFSR--MSWIKPNFLWMMYRAGW-ASK-PNQERILAIEISKQNFELILEEAIHSSYVAEVYG-------------------------------------------------SRADWQAKLKAS--NVVMQWDPDHAPNGDKLQR----RAVQLGLR-NELLK-NFGTHWA--VSIQDITDFVLEQ-GK-CLRGQKMD------------------ELLVMQEQVI-AIDNPE-VVKRLG-LA-------
    336471510       FSNL-----PPKPPSRQIRALQEDDGTTITVYQAYPSTIATAAVIHQRLDASPEFRTTR--MTWIKPSWAWMLYRSGY-SYKDPGQERILAIKMKREDFLGLLGRGVLTHGTAPPRP----------------GPQQGQGITSDAQGRTSGER---GEEAAPKESTRESKRKDRLQSL--DVKIQWDPERTVRLHSLNY----RSIQIGIP-AGLIR-EWAQDMI--VNIEDVTDKARTL-KK-ILDERPDV-----------NDEELAELGLIPKETEF-EVPVEL-RSRLG-----------
    169773039       MATNN----ANLQPFRAIRA-QSTQ-STITVYQAFSPEIAEPALRAQKF-VPP-FSRTR--MTWIKPSFLWMAYRCGW-ATK-PKQERVLAIEITREGFEWALRRSCLSHVPGSRDQ-------------------------------------------------DQEKWRQRLRES--PVRVQWDPERDLWHRPLGY----RSIQIGLS-GEAVE-RYVDEWI--VSITDVTGLMGDV-KR-ALDKADAE----------------GAEGLLPVESVY-PLSEEL-RDILD--AT-------
    85068247        FSNL-----PPKPPSRQIRALQEEDGATITVYQAYPSTIATAAVTYQRLDASPEFRTTR--MTWIKPSWAWMLYRSGY-SYKDPGQERILAIKMKREDFLGLLGRGVLTHGTAPPRP----------------GPQQGQEMTSDAQGRTSGER---GEEAAPKESTRESKRRDRLQSL--DVKIQWDPERTVRLHSLNY----RSIQIGIP-AGLIK-EWAQDMI--VSIEDVTDKARAL-KK-ILDERPDV-----------IDEELAELGLIPKETEF-EVPVEL-RSRLG-----------
    182438632       MNT------QALPPRYEIRA-RQSA-TTVTVYQAYRPAIGLPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQEVVLAVEIDRGGLEWALAHAELSHYAAEVHP-------------------------------------------------DQASWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEAAR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVRA---AS-------
    254387007       PDPA-----PVPVPNRAVRA-AHTA-RTVTVYQAYAPHLGLPAARDGRF-PHA-WKRER--MTWVKPSFLWMMYRCGW-ATK-ADQETVLAVEITREGFDHALRRACLSHYEPGTHA-------------------------------------------------DRASWQRALRGA--PARVQWDPERDLHLNPLPY----RSLQLGLS-GPASR-AYADEWT--LSIRDVTPLAREI-HG-LLRAGNAD----------------AARALLPGETPY-P-SPPL-PHLGA-----------
    70988759        ---------MARHPYRQIRA-KYTS-TTITVYQAYSPSIADAAVDAQKF-VPP-FSRTR--MTWIKPSFLWMAYRSGW-ARK-PKQERVLAIDITREGFEWALQHSCLSHYPGHDVE-------------------------------------------------EKAKWQKRLQNS--PVRVQWDPERDLQFTPLDY----RSIQIGLS-ADAVD-KYVDDWI--VGITDVTEVMRQI-EK-CLAEDRME----------------DATRLVPAEEVY-PLSEEL-KGILE--AT-------
    302535927       P--------APETPRHQIRA-AHTA-TTVTVYQAYAPHLGVPAARDGRF-PPA-WKRER--MTWIKPSFLWMMYRCGW-AAK-ADQETVLAVEISREGFDRALAQACLSHYVPGVHA-------------------------------------------------DREAWKASLAGS--PARVQWDPERDLHLNPLPH----RSLQLGLS-GPASR-AYADEWT--VSIRDVTPLAREI-HG-LVRAGDLD----------------AARALLPAETPY-PAGPLP--HLGA-----------
    66813652        M--------SNKNYKRIIKA-VYND-ETIRVYQAYNKEIAEGAVKNQRF-VDP-WLTTR--TTWIKPSLCWMMYRAGY-GYKDKNQERILAIDIKREAFEWILDTYYDNNNENLNDL------------------------------------------------------KAYAKN---SLVIQWDPERSIKIGKLEN-GELRSIQIGIK-PNLTQ-KFNNEWI--AEINDITDIVHQI-KR-EIDDGNIE----------------KAISLLPIEKVYTPINVKF-----------------
    66802638        M--------TDNNYKKIIRA-VFTD-DTVRVYQAFNSKIADDAILNQKFTLESGWSDNR--TTWIKPSFCWILYRSGY-ACK-HNQERILAIDIKREAFEYILENHIDAHETGKSAI------------------------------------------------------PSSKK----KIVVQWDPERNISISKLDGCGDIRSIQIGVK-KAKIK-EYNEQWI--QAITDVTPIAHQI-KK-ELDKGDLE----------------KAKSLLPDELVYTPKNVRF-----------------
    124007793       -----------MNNTQEIRA-QYDA-DTITVYQAYGKAIALPATKVNQF-APP-FSFQR--MTWIKPSYLWLMERSNW-ATK-PQQEFILGIKIKRAYWEYALSLGVLTHPDLAIYT-------------------------------------------------DGLDWEQKFSQA--KVHIQWDPERTLRGAKLQV----RSIQVGIS-RHLIE-QYNNEWI--VAIDDLTPLTRKI-SQ-LKKQGKYK----------------EAKQLLPKEQVY-VLPDEL-QKRIG--VR-------
    119497805       ---------MARHPSRQIRA-KYTS-TTITIYQAYSPSIADAAVDAQKF-VPP-FSRTR--MTWIKPSFLWMAYRSGW-ARK-PNQERVLAIEITRKGFEWALQHSCLSHCPGQDAE-------------------------------------------------EKAKWQKRLQNS--PVRVQWDPERDFQFRPLDY----RSIQIGLS-ADAAD-KYVDEWI--VGIADVTEAMRQI-EK-CLAEGRTE----------------DAARLMPAEEVY-PLSEEL-KDILE--AT-------
    121719366       ----------MNPPYRQIRA-KYTP-TTITVYQAYNDTIATNALAAQTF-VAP-FSRTR--MTWIKPSFLWMAYRCGW-GKK-PRQERVLAIEITRDGFEWALRHSSLSHYGGRDPE-------------------------------------------------GKAAWQERLRAR--PVRVQWDPERDLEFKGLAY----RSIQVGLG-GEAVE-RYVDEWI--VGITEVTETMREI-EQ-CMEEGRME----------------EARALVPLEEEY-PLSEEL-REILE--AR-------
    303240837       --------------MNRIFA-YFDD-EGVYVYQAFKPNIVKNAVEIGTF-GKG-FGLDR--ITWIKPSFGWILHRSSY-ATK-HRMEAIAKIKLSHKAWLEILSQSVPSQFDSSRYK-------------------------------------------------NETIWKADFEKS--DVIHQM---------KLNR----RAIQIGLR-NEAIK-KYVYEWI--IGVEDVTDLAKEI-SS-IIKSGKDP------------------SSLLPDISEY-PISDDL-KNIIG--YT-------
    322708785       M--------ASTPPYRQIRA-TYTP-DTITVYQAYKRSIADAAVKHQKLNASPDFRPGR--MTWVKPSWSWMMYRAGY-SYKDPGQERILALRMKHEHFIALLDKGVLSAHTERIGG------------------------------------------------VGGGEQGPRDKTS--EVRIQWDPERDERLRVLPY----RSIQIGIP-GSLSK-KWAEEWI--AEIEDVTEKARGL-KA-ALDERADV-----------TREELLDMGYVPEERVF-EVGHDI-RERLG-----------
    256376409       -----------MAPQRQIRA-DYDD-SHITVYQAYSSAIADPALAAGRF-VPP-FSFGR--MTWVKPSYLWLMHRSNW-ARK-PGQERVLAVRITRAGWERALAQAVLTGSPGLEGA---------------------------------------------------------------RVHVQWDPERSLRGAALNH----YSIQVGVG-RDVVR-ELVDEWT--TGVADLTGRTRRI-AA-LLQAGRAE----------------QARRLLPPERPY-PLPVAI-ATRLD--AG-------
    322699163       M--------ASTPPYRQIRA-TYTP-DTITVYQAYKRSIADAAVEHQKLDASPDFRPGR--MTWVKPSWGWMMYRAGY-SYKDPGQERILALRMKHELFVALLEKGVLSAHTERIGG-------------------------------------------------GGGEQGPRDKPS--EVRIQWDPERDERLRALPY----RSIQIGIP-ASLSQ-KWAEEWI--TEIEDVTEKARGL-KA-VLDERGDV-----------TREELVDMGYVPEERVF-EVSQDI-RERLA-----------
    346318305       SQA------TPTVPYRQIRA-LYDD-STITVYQAYSPSIADAAVAAQRLDASPDFRPGR--MTWIKPSWAWIMYRAGY-SYKDARQARILALRMTHAHFLGLLNRGVLSHGGNLAPD-------------------------------------------------------RLDKNA--EVRIQWDPERTPALHRLPY----RSIQIGIP-GSLSA-QWVADWI--ISIEDVTDTAREL-KR-TLDENPDV-----------ELQELVNRGLVPVEKFF-PVPESI-MAKLD-----------
    162457230       -----------MPKLHEIRA-DYDA-ETIVMYQAYAPAIAEPALAAQRF-VAP-FSFGR--MTWIKPSFLWLMHRSNW-GRK-AGQERILAVRIRRTGWEHALSLAVLTSPEATVFR-------------------------------------------------SPDEWSKAFAEA--KVHIQWDTERNLRGGPLPC----YSIQVGVG-RDLIR-EYAESWV--VAIEDRTPLVRKM-YQ-QIQAGHAD----------------SAAKSLPRERPY-AVDEKI-ARRLL--ID-------
    340521231       MSR------PSDIPHRQIRA-SHDK-DHIVVYQAYKPSIASAAVKAQKLNASEDFSPDR--MTWIKPSWCWMMYRSGY-SYKDPNQSNILAIKMKMEHFLELLRQGVLSNHPSEHAR----------------------------------------------VDKDSTNKTAHERPS--DVRIQWDPERNARLEALPY----RSIQIGIP-PNLGT-KWVDEWI--VGIEDVTERAREL-KR-VLEEEPHI-----------GEDELVKRGLVPEETPV-DVPDDI-MTRLD-----------
    302529076       ------------VPRRDVRA-GYTD-QTITVYQAYSRHIADVAVESQTF-AAP-FKRER--MTWIKPSFLWMMYRSGW-ATK-PEQERILEIQLTREGFEWALAHAALSSYEPGAYA-------------------------------------------------GQQHWAERKRTS--PVRIQWDPDRSLTLAPLDR----RAIQIGLS-GEAVE-RYLDQWI--AKITDITPFAERI-HR-HVSSGRLE----------------AAREELPGERVY-PVPAPI-LGMIG--AS-------
    262199521       ---------MSQTSTREIRA-DYNA-DSIVVYQAYRDDIADPALREQRF-VEP-FSFHR--MTWIKPSFLWLMHRSNW-GAK-KGQERTLRVRIGRAGWEEALAQGVLTSPDGPVFG-------------------------------------------------NAAKWQRAFAAA--KVHVQWDTERSLRGAALDH----LSIQVGLG-RHIIQ-RFVEEWI--VAIDDMTASVAKM-RR-LLQQGKVA----------------EAKRLLPSERVY-SVPDDI-ARRLW--FD-------
    238490968       MATNN----ANLQPFRAIRA-QSTQ-STITVYQAFSPEIAEPALRAQKF-VPP-FSRTR--MTWIKPSFLWMAYRCGW-ATK-PKQERVLAIEITREGFEWALRRSCLSHVPGSRDQ-------------------------------------------------DQEKWRQRLRES--PVRVQWDPERDLWHRPLGY----RSIQIGLS-GEAVE-RYVDEWI--VSITDVTGLMGDV-KR-ALDKADVE----------------GAEGLLPVESVY-PLSEEL-RDILH--AT-------
    115387213       MEGSHASTVHHAHGYRVIRA-KYTP-TTITVYQAYSPEIADAAIRAQRF-VSP-FRRQR--MTWIKPSFLWMAYRCGW-ASK-PNQERVLAVEITREGFEWALRHSCLSHAAAT----------------------------------------------------KQEEWQQKLQSR--PVRVQWDPERDLSFRPLGY----RAIQVGLG-RESVD-RYIDDWI--VSITDVTQTMKQV-AQ-YVADGMVE----------------EAKACLPEERVY-PLSDEL-REILD--AT-------
    290963088       -----------MAPPYQIRA-DYDA-DTIVVYQAYAPAMADAALRAGRF-VAP-FSFRR--MTWIKPSFPWLMHRSNW-ARK-PGQQRVLAVRMSRHGWEEALSRAVLTTEDPAAVA-----------------------------------------------------------RA--AVHVQWDPERSSRGAALNH----YSIQVGIG-RDLIR-TFTDEWI--VSLTDLTPQVRKA-AT-LTQTGHAA----------------QAQRLFPAERVY-PLPPHL-ERLL---TS-------
    168699093       -----------MGAAREIRA-DYDR-DTIAIYQAYPPAIADAALAAGRF-VPP-FSFHR--MTWIKPSFLWLMHRSNW-AQK-RGQERVLCVRVRRSGWEAALAQAVLTSFEPTVFT-------------------------------------------------DPDTWAEQFATA--RVHLQWDPERSLRGAGLPY----DSIQVGLS-RHVIR-EYADDWV--ARIEDYTPVVRKV-YT-LLQSGRAD----------------KARRFLPPERVY-PVGGEL-GRRLS--LR-------
    328866607       MSS------EFISKEFQIRA-VYNK-ETIRVYQAYNNEIADYAVKHQTFTGCPHWSTER--TTWIKPSFLWMMYRSGW-AQKDKNQNRILAIDIHIKDFEYAIQNNYKSSTKQKYQI------------------------EGQELPPPSKEHS------------QPPVSKVDKSNY--DIVVQWDPERSIKLGKLGSN--IKSIQIGIK-KRIAE-QYSSNWI--TQITDITNQCLEI-KQ-LLDNGHLD----------------QAQSLLPIEKVY-IPSFIK-----------------
    288940281       ------------MPENSVRA-IFDD-KTIRVYQAYRADIALPALAAGRF-VPP-FKMDR--MTWIKPSFGWMMYRSGY-ASK-PGQEFVLGIDITRDGFEWALAHATLSSFKPSVHP-------------------------------------------------SYEVWKADIESK--PVRVQWDPERDWKLQPIRGV---RAVQIGLS-REAIK-YYARDWI--VKIEDVTPLVKKASQA-IIMPPDLP----------------SA-----LERPY-PLPADL-AYIC---CD-------
    320095331       ------------QPLRQIRA-LYDA-TTITVYQAYSPAIADAALRAGAF-VPP-FKEER--MTWIKPSFLWMMYRSGW-GTK-PGQERTLAVRITREGFEAALADACLSHFDPDVHS-------------------------------------------------TRQAWSAAVAAC--PNRIQWDPERNASGDPLAH----RSIQIGIG-PARVG-AYAHEWV--VGISDVSDLVEAL-RL-AP-ARLGE--------------------LGPRERPY-PLPAGL-AQRIG--AS-------
    256395290       MGN------ENNLPLHQVRA-DYDR-ETIVVYQAYRAQIAEPAVRAQRF-VEP-FSLQR--MTWIKPSFLWMMGRSNW-ARK-PGQEHVLAVRITREGWENALSQAVLTGYKRGVHA-------------------------------------------------DHADWEQQMKHA--RVHVQWDPERTLSGAVLDA----RSIQVGLS-RHVVA-DYVNAWT--TEIRDITPTVRKM-AD-LLKEGRKD----------------RAAQHLPKERPY-ELPPHIA-RRLR--GE-------
    238061717       ------------VPVRQIRA-RYSA-ATITVYQAYPPQIALPAVSAGRF-VAP-FKRDR--MTWIKPSFLWMMYRCGW-ATK-PGQERVLSIDITRDGFEWALARACLSHYDRDVHG-------------------------------------------------DKATWSRQLKTS--PVRVQWDPERSLHLNALPY----RSLQVGLS-GEAVD-RYVDDWI--VAVTDITPTVERA-RD-LLRRGDDQ----------------AAAAQLPVEYVY-PLPDRIA-VGLH--AS-------
    162457272       AAQSA----RWPTAGRHILA-QFDA-ETIVVYQAYRPSIARHAALHQRL-GGPEFSFGR--MSWIKPNFLWMMFRSGW-GTK-PDQEAVLAIRIQRAGFDAILAAAVPSGFVPDLHP-------------------------------------------------SEEAWKSDLQRS--DVRLQWDPDHHPSGAPVAR----RAIQLGLR-GATLR-RFAEEWT--VGVEDISALVAEQ-RE-VLRGRGVG------------------ELEIPREEVY-WPTAAEAARRVG--IE-------
    159037621       ------------VPVRQIRA-RYSA-DTITVYQAYPPQIALPAVAASRF-VAP-FKRDR--MTWIKPSFLWMMYRCGW-ATK-PGQERVLSIDITREGFEWALARACLSHYDRDLHG-------------------------------------------------DKATWLRQLKIS--PVRVQWDPERSLQLKALPY----RSLQVGLS-GEAVD-RYVDDWA--VAITDITPTVHLV-RD-LLRSGDGQ----------------AAAALLPVEQVY-PLPDQIA-VGLN--AS-------
    124002814       -------------MQKQIYA-AYDD-EGLFVYQAFKPKVVATAAAKGTF-GTG-FNTNR--LTWIKPSFAWVLQRTKY-ATK-HRMNAIARIKLSHEGWLHLLRQAVPTQYDAQRYT-------------------------------------------------NEEDWQQALDKA--VVIHQWDPERDLLGKKLDR----AAIQVGVR-SEELSLRYVNEWI--LGIEDVTELAHAI-GS-LQKRRNPP------------------LPETPEERLY-PVSEEMA-LALG--CF-------
    333374005       MEQME----RWPAEGRHILA-QYDP-SSIVVYQAYKPKIGRFAVDHGYF-GGE-FRFNR--MSWIKPNFLWMMFRSGW-GTK-PDQETILAIHIERSGFDSLLEQAVHSTWNQSLHP-------------------------------------------------DREAWQKDLRKS--EVRLQWDPDHDPFGQPVKR----RAVQLGLR-GETLI-RYARDWI--VEIEDITNFVKKQ-KA-YVDQGKLD------------------RLETPQETVY-PPASVQGRV--------------
    168703011       PEQVK----VWPKDGRHILA-QFDH-DSVVVYQAYSPAIGRYAIEHGRF-GGA-FSFER--MSWIKPNFLWMMYRSGW-GTK-ENQEVTLALRLRRAFFESLLAEAVPSTWDRDLFA-------------------------------------------------TFEEWSRAVGRS--AVRLQWDPDHHPSGAKLDR----RAIQLGLR-GRVLE-AFGTTEL--LEVIDLSEFVAQQ-RE-LLAARGTS----------------AL--ITPRERVY-SPTDPAIAAQLR--LA-------
    298250918       EDQLK----VWPQQGKHILA-QYDE-TSVVVYQAYRPAIGHFAARRGYF-GGG-FSLER--MSWVKPNFLWMMYRSGW-AQK-EHQEVVLAVRLKRAAFDEILAQAVHSTYKEALYG-------------------------------------------------SHEAWKQALETS--HVRLQWDPDHDPRGVKLER----RVIQLGLR-GPVLA-QYAREWI--LDIEDISQFVYEQ-YH-YVESGAFD------------------QLIMPAERVY-PIVNTHIAARLG--II-------
    300854685       -------------MEKKICA-SYTE-NSIRVYQAYNNKVAEECLKLGTF-GES-FKMER--MTWIKPSFLWMMYRCGW-GKK-ENQERVLAIDISRNGFEEMLSNVVLSTYSEKVYK-------------------------------------------------SHENWKFQLKTS--NVRCQWDPERDIYGNKLDR----RSIQIGLQ-GEMVY-KYVNNLI--LNIEDMTNKVSKW-SK-DIRDKKLD------------------FKELPVENEY-YV-DNLI-KEKLGMSI-------
    296121824       AEQAE----QWPHEGRHILA-QFDQ-DTIIVYQAYQPAIGHYTAMHRTF-GGG-FSYSR--MSWIKPNFLWMMYRSGW-GTK-ANQEITLALRIRREFFDALLAEAVPSSWDPTEFV-------------------------------------------------TEDEWSQAVSKS--SVRLQWDPDHHPTGAKLER----RAIQLGLR-GDVLK-AFGQQEL--IDVIDISDFVSAQ-RE-RLLSRGTS------------------ALVTPLERVY-SPADPEIALRLK--LA-------
    340377247       IEQQTG---VWPKDGKHILA-QYDD-EDIIVYQAYSRGIGSYAIEHQKF-GGPLFSYSR--MSWIKTNFLWMMYRSGW-GSK-ENQEMVLAVRISRNGFDTILSHALTGHDEKLLGK----------------------------------------------------------GQS--PVRLQWDPDHHPDGSALSR----RAIQLGLR-NDILA-RYGDEWT--TDITDISDFVHDQ-YQANVISRQWD------------------KLLVPRERVY-HVTNEEIAKQIK--LI-------
    281203630       ------------MKERIIRA-IYDD-TTITLYQAFNSVIGRYAVKNQSFIGCPGFKIDR--MTWVKPSFLWMMYRSGW-ATK-HNQECILAIRIKREGFEWALQNSSLSQHLSISAE-------------------------------------------------QREEHREQLLSQ--PVRIQWDPEKDIDLKALPY----RSIQIGLS-GVAVT-KYLNEWI--VSIEDITPKCKTI-YQ-LLATHQRE----------------EALRQLPQESIY-NIDNHHIEIHIN--LS-------
    290974944       M--------ITQQVTGSIIT-IDDE-ECIVFYQAYNSGIADWVVKNQTFDECPNFDKKR--MSWIKPNYLWMMYRSEY-ATA-KNQTNILALFITRKSFEEELLKHAVCAMYYPELE----------------------GYYKSQKEWKVNCSQMKEKVAQLMNKNDTDTI-MTDNVC--FARVQWDPYHTPAFGNING-GLTRAIQIGVK-GSFLR-SMCKSGA-CKKIEDITKYVHEQ-HA-----EYLK----------------TKDLLIPVERYI-HINDKDIKGRLA--IT-------
    290974534       -EARN----EWPDDGNHIIA-SYTE-DAVLVYQAFNDEIADYAVKHQKFDGCPSYNDTR--MTWVKSNWLWMMYRSNY-ATK-QNQTRILGLWLKKSAYDDILKKARLKGAGAGL------------------------------------------------------------------TRAQWDPDYSPELEPIKRR---RDLQLGIK-KRETF-RNGEDF---VEIVDCTELAHIS-KK--T-------------------------KTIPHERVYTPDNEVCI--NLQ--VS-------
    83647694        LEQTS----LWPASGRHILA-HQDQ-DTLIVYQAYRPEIGEYAIKHGRF-GGA-YSYSR--MSWIKPNFLWMMYRCGW-GMK-EGQEVVLGLRIRRQFFEDILSQAVPSSYNPEEFA-------------------------------------------------TQETWKEAVQNS--NVRLQWDPDHTPNGAKCER----RAIQLGLR-GDMLA-RYGKEEI--LEVIDFREFIAEQ-RA-QATPDRYA----------------EL--LTPQEQVF-IPSDDAIGARLR--LD-------
    294669065       ------------MNQNTIRA-VYGE-HTIRVYQAYSDPIADAALAHGTF-VSPPFKMER--MTWIKPSFLWMMYRAGW-GLKDEGQKRILAIDISREGFEWALRHACLSHPPAGMGK---------------------------------------------------DDWQRLKAQS--PVRIQWDPERDLQLKALPY----RSIQIGLS-GEAVN-YYVNDWI--QDITEITPLARQI-RE-LVEQNRLD----------------EAQILLPPEQPY-PAVYVPI----------------
    21223327        ----------MQQPQREVRA-VHTA-STVTVYQAYSPEIGLPAIREGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-AAK-AGQETVLAVEIGREGFEWALRHACLSSYQPGVHP-------------------------------------------------DRATWQREVKRS--PTRVQWDPERDLRLQPLPY----RSLQLGLA-GEAAR-RYADEWT--VAIRDVTPLAHEI-HG-LVRDGDLD----------------AARRLLPREQPY-PAAEELL-SNLRP----------
    297561069       ----------MDVPRHQIRA-LHTD-STVTVYQAYAPSLGLAAAREGRF-PSA-WKRDR--MTWIKPSFMWAMYRSGW-GLK-RDQETVLAVEITRAGFAWALRNACLSHHAPAVHP-------------------------------------------------DRETWRARLREA--PARVQWDPERDLYLSPLEH----RSLQLGLA-GEAAR-RYADEWI--VSITDVTPLARRV-HT-LVQEGDTA----------------AAARLLPAERPY-PVAQGEL-DHLRPARE-------
    333027909       -----------PVPRHEIRA-LHTA-DTLTVYQAYRPSLGVPAARDGRF-PEA-WGRGR--MTWVKPSFLWMMYRCGW-GTK-EGQETVLAVEIAREGFLWALRNATLSHFERGVHG-------------------------------------------------DRAEWQRSLRRA--PARVQWDPERDLHARPLEH----RSLQLGLS-GEASR-RYADEWI--VGIRDVTPLAREA-HG-LVRDGELD----------------GARALLPVERPY-EVPVDAL-AGLLP-VP-------
    295839520       PPPAAS---PPEIPRHQVRA-LHTA-DTLTVYQAYRPSLGLPAARDGRF-PPE-WGRER--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAVEITRAGFLWALRHAALSHYEAATHG-------------------------------------------------SREAWRRALRGA--PARVQWDPERDPRGRALAH----RSLQLGLS-GEASR-RYADEWT--VGIRDVTPLAREA-HA-RVREGRPE----------------AARALLPVERPY-EVPADAL-AGLLP-AP-------
    297202026       --------------MG------------------------ALRRRTEPWNPPRERVCEHA-LTWIKPSFLWMMYRCGW-GAK-AGQETVLAVEISRDGFEWALRHACLSSHVRGAHP-------------------------------------------------DRAAWQRQLKRA--PARVQWDPERDLHLRPLPY----RSLQLGLS-GEAVR-RYADEWT--VAIRDVTPLAHEI-HA-LVRGGDMA----------------SATGLLPQERPY-PAEAESL-AHLLA----------
    312886331       KQSLT----LLPQNGQHILA-HQTG-NDMVVYQAYKPGIAKFAVDNQFL-GGPDFSFTR--MSWIKPNFLWMMYRCGW-AEK-ENQERVLAIWIAQKDFEEILRQAVFSSFNPQYYR-------------------------------------------------DHDHWKNELSLK--EVRLQWDPDHDPYGNKVER----RAIQLGLK-GEMLR-FFSSK-I--KSIEDITDFVNQQ-KN-LLDHHGLD------------------ELEVPVETIF-KTSDPIL-NKQIG-IT-------
    297194315       ---------MTDEPRHRVRA-RYTD-DTVTVYQAYSPAIGVPAARDGRF-PAA-WKRER--MTWIKPSFLWMMYRCGW-ATK-ADQETVLAVEIRRDGFEWALRNACLSHYQEGVHE-------------------------------------------------SREAWKRELRQA--PARVQWDPERDLRLNPLPY----RSLQLGLG-GDAAG-RYADEWT--TGITDVTPLARQM-RR-LVLEGDLA----------------GAGRLLPEERPY-PADTGLL-GHLVPSAG-------
    297162424       M--------AMQEPRHQIRA-LHTE-STVTVYQAYAPHLGLPAARDGRF-PTA-WKRDR--MTWIKPSFLWMMYRCGW-GAK-EGQETVLAVEITREGFEWALGRSCLSHYERGLHP-------------------------------------------------DQAAWKRALKAA--PARVQWDPERDLRLRPLPY----RSLQLGLS-GGAAR-RYADEWT--VAITDVTPLAHEV-HA-LVRRDELD----------------AAVRLLPEERPY-PAGDELL-SHLRAPVA-------
    328884339       MEETRT---ADDEPKYRIRA-LHTD-RTVTVYQAYRPEIGLAAAREGRF-PAI-WKRDR--MTWIKPSFLWMMYRSGW-GTK-EGQETVLAVEITREGFEWALRNACLSHHVRGFHP-------------------------------------------------DQATWKARLRTA--PARVQWDPERDQRLRALPY----RSLQLGLS-GEASR-RYADEWT--VSVTDVTPLAHRV-RD-LVRAGDLE----------------AAGRLLPREEPY-PESAGLL-EHLRVPQA-------
    297202028       ----------MEEPLHRIRA-LHTA-STITVYQAYRPEIGGPAARKGRF-PAA-WKPDR--MTWIKPSFMWMMYRSGW-GMK-ESQETVLAFEITREGFDWALRHACLSHYVRGLHP-------------------------------------------------DRDTWQRDLKRA--PARVQWDPERDLHLHPLPY----RSLQLGLS-GEASS-RYADEWI--VSISDVTPLAHEI-HA-LVRDGELD----------------SAARLLPQEQEY-PANAELL-AHLCP----------
    291438820       --------------MA----------RRPRRCSLHRDDGSLPALTQAGW--AHEKVCERG-STWIKPSFLWMMYRCGW-GTK-EGQGTVLAVEITREGFEWALEHACLSHYEQGLHG-------------------------------------------------DRATWKRRLERA--PARVQWDPERDLRLQPLPH----RSLQLGLA-GEAAR-LYADEWI--VSITDVTPLAHAV-HA-QVRSGDLD----------------IARQLLPRERPY-PMNDELL-AHLHQ----------
    329935335       ----------MAPPQREVRA-AHTD-ATVTVYQAYAPEIGVPAAEAGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-QGQETVLAVEISREGFEWALRHACLSSYAPGVHP-------------------------------------------------DRTTWQRELKRA--PTRVQWDPERDLYLRPLPY----RSLQLGLA-GEAAR-RYADEWT--VSLTDVTSLAHEI-HA-LVRDGDTD----------------SAARLLPRESPY-PGQDELL-ARLRG----------
    345013407       ----------VAEPKYQIRA-LHTE-STVTVYQAYAPEIGLPAAREGRY-PAV-WQRDR--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAAEISREGFEWALEHACLSHYEHGLHA-------------------------------------------------DRATWKRQLKRA--PARVQWDPERDLHLQPLAH----RSLQLGLT-GEAAR-LYADEWT--VSITDITSLAHTI-HA-HVQGGDLD----------------AARQLLPRERPY-PVNEGDL-AHLYQ----------
    302548144       ----------MEDQNHQIRA-RHNP-ATVTVYQAYAPHIGLPAARDGRF-PSA-WKRDR--MTWIKPSFLWMMYRCGW-GLK-EGQETVLAVEITHEGFAWALRNACLSHYVRGLHP-------------------------------------------------DQAAWKRQLHRS--PTRVQWDPERDLQLRPLPY----RSLQLGLA-GEAAR-RYADEWT--VSITDVTPLAREV-HA-LVRAGDLD----------------AAAARLPEERPY-PAADDLL-SHLRVPRP-------
    330801102       ----------MSGYKRIINA-VYDD-ETVRVYQAYKATIADDAIKNQRFTEASGWKQDR--MTWIKPSFCWMLYRSGY-ATK-HNQERILAIDIKRSAFEWILENHIDSTETAKSSI------------------------------------------------------PSEKK----KIVVQWDPERNFKIGKIDGCGDVRSIQIGIK-AVKTK-EYNEDWI--VRIQDVTDLAHQI-KE-LVELKDFE----------------KANALLPNERIYKPKNVRFN----------------
    291453417       TNPT-----ALPHPTHQIRA-RQTP-TTVTVYQAYPPSIALPAARDQRF-PAA-WKRDR--MTWIKPSFLWMMYRSGW-SRK-EGQERVLAVEISRAGFDWALGHACLSAYHPDVHA-------------------------------------------------GRDGWREALRGA--PARVQWDPERDWRLRPLPW----RALQLGLS-GEAVR-RYAEEWL--VSVVDVTGLAHAV-QE-RVRAGDEA----------------GARELLPEERVY-VPEGGLP--ASLVG---------
    29829850        ----------MEETQRRIRA-VHTT-STITVYQAYSPEIGLPAVREGRF-PTA-WKRDR--MTWIKPSFLWMMYRCGW-GAK-AGQETVLAVEITRDGFEWALRHACLSSYVRGVHP-------------------------------------------------DRATWQRQLKHA--PTRIQWDPERDLHLQALPY----RSLQLGLA-GEAAR-RYADEWT--VSISDVTPLAREI-RT-LVGNGDLD----------------SAARLLPQELPY-LPADELP--AHLRP---------
    332668288       -------------MCTNIIG-YQTE-EEIVVYQAYKPEIAKFAVENQKL-GGASFGFQR--MSWIKPNFLWMMYRCGW-AEK-ENQEHVLAIWIKKQDFELILEQAVLSSFQKEIYH-------------------------------------------------TEEDWKLQLSQS--EVRLQWDPDHDPKGNKLER----KAIQIGMK-GEMLH-LFANKYI--QHIEDITTFVRKQ-KL-YVDRRELE------------------KLLIPKESIF-TSLSAQR-KTHTL-AT-------
    260802161       VSQIDH---HWPPTGKHILA-QYDD-NSVVVYQAFRPEIAEYAVKNQRF-GGSHYSWER--MSWIKPNFLWMMYRCGW-ASK-KGQERVLAVRITRTGFDEILANAYTPKTQAEAGL-------------------------------------------------PKDQL---------KVRLQWDPDHDPSGTSVQR----RAIQLGLK-GEILS-HFAQDWI--VSITDVTDFVHEQ-HN-VLQTSGTE------------------QLQVAAERVY-QVTDPKT-KALIG-VE-------
    260782199       VSQVQQ---HWPQTGKHILA-QYDD-NSVVVYQAFRPEIAEYAVKNQRF-GGPHYKWER--MSWIKPNFLWMMYRCGW-ASK-KAQERVLAVRITRNGFDEILANAYTPKTQAEAGL-------------------------------------------------PKDQL---------KVRLQWDPDHDPSGTSLQR----RAIQLGLK-GEILN-HYAQDWI--VSITDVTDFVHEQ-YN-VLQTSGTE------------------QLQVAAERVY-QVTDPKT-KALIG-VE-------
    158335219       LHQKD----RWPQQGRVILA-QYDT-DSIVVYQAYRPAIGNFAAQHGYF-GGE-FKLSR--MTWIKPNFLWMMYRSGW-GAK-PGQEVVLAIRLQRSAFDSILAQAVHSSFQSGLYD-------------------------------------------------SQESWQKAVQTS--DVRLQWDPDHNPAGHKLER----RAIQLGLR-GDAIR-KYAQEWI--LDIEDISDFVADQ-RQ-HVVSGNYE------------------ALLTPAEAPY-PVSDLKT-AHRLQ-VP-------
    72006229        CDQNNV---CWPIAGKHILA-QFDE-HSVVVYQAFCPAIAKYAVDHQRF-GGDKFSFSR--MSWIKTNFLWMMYRCGW-ASK-PNQERVLAVRITREGFDEILSKAYTPQTQATAGL-------------------------------------------------GKEEI---------EVRLQWDPDHAPNGDKMDR----RAIQMGLK-GETLR-KYATEWI--VSIRDVTDFVKEQ-SK-NTDRKRLN------------------LLDVAQERVY-PVSNPKT-AQLIG-LG-------
    300867123       LTQVS----RWPKAGRHILA-QFDE-NSIVVYQAYRPAIGDFAALHGYF-GGE-FKLSR--MSWIKPNFLWMMYRSGW-GTK-EGQEVILAVRLKRSAFDEVLTAAVHSTFVSEVYA-------------------------------------------------SEKEWKQAAKNS--SVRLQWDPDHHPNGSQEER----RAIQLGLR-GEILV-HYAQDWI--INIEDISEFVQEQ-HQ-NLKEG-MA------------------NLLTPSEEVY-PITNSDT-AKRLQ-IS-------
    291237935       MEIMK----LWPKNGNHVLA-QYDD-HNIVVYQAFCPEIANYAVKNQRF-GGPHYSFDR--MSWIKPNFLWMMYRCGW-ATK-SKQERVLAVRITREGFDSILSKAYSAQAQKAAGL--------------------------------------------------------NKNDI--QVRLQWDPDHKPSGAPTLR----RAIQLGLK-GEILR-KYATEWI--VSIEDVTPFVQEE-MV-KLTPENID------------------KLVVPIEKVY-HVTDKKT-ANLIN-VE-------
    307105263       VRQEAE---FWPAVGRHVLA-QATE-DTVVVYQAYTPSIGVLAAGQGDFRGIPGFSETR--MTWVKTNFLWMAFRCGW-ASK-PNQETVLAITLKRPFFERMLAASLSTSAGTTAKG----------------------------------------------------------PCIGADVVLQWDPDHLPDGSKHPGR---RAVQLGLR-GGVRD-EYISGRH-TVCIEDITPFVREM-GA-IAAGGEPR----------------WVGLLVPSERVL-RLRD-EV-RSHIA-AD-------
    149922143       LEQRE----RWPQTGRHVLA-HYDD-EAVVVYQAYNPAIAAWAVKHQRF-GGP-WSFER--MSWIKPNFLWMMFRCGW-ATK-RDQERVLAVHLERAGFDAILGQAVHSSFVAERYA-------------------------------------------------DRATWQARGRRS--DVRLQWDPDHGPRGGKLER----RAIQLGLR-RATLR-AFAEGWC--RGIEDITPFVHAQ-RT-FVDSRQLG------------------RLQTPLERVY-PVLDAEV-AAHLG-VT-------
    299472429       S--------APTATGRCLLA-QFTD-REVIVYQAYKPELGNFAVENQYF-GGDGFNFKR--TSWVKPNFTWMMHRCGW-ASK-QNQEVVLALALRRDFWDDVLSQAVMSNYESYRST-------MSAEVPR---------------------------------GDAQRRWKASLQAS--DVVMQWDPDHMPFTGHKTNH---RAIQLGLR-GDALA-AFRGPAFGETGIQDVSAFAKAT-EE-IHRPRAADGGGGGGHPDAPAATPPPPALLLPIEETY-PVVDASV-AQRLG-ID-------
    170940179       TM-------STPTPYKQIRA-LHTP-RSITLYQAYNHPIASAAVSAQSLTASPLFKTTR--MTWIKPSWAWMLYRSGY-SFKDANQSRILALTMSHEDFLWLLSQGVVSHRSPEEKG-----------------------------------------------------DQGGKKLG--GVRIQWDPERDVKMERMGY----RSIQIGIPGGEVCE-RWVG-MV--KKIEDVTDKAREL-KR-VIDERPEV-----------TVGVLKEMGLVPEEKVF-EIEDEEV-RRRLG----------
    87310926        -----------MFHFREIRA-SFDR-DTIVVYQAYNDAIANAALTVGKF-VPP-FSFQR--MTWIKPSFLWLMERSGW-GTK-ANQTRILAVRIARSGWDAAIGQGVLTSYHSDIHR-------------------------------------------------SQDDWRTQFENA--MVHVQWDPERSLRGKKLEY----RSIQVGVG-RRLIT-EFAEQWT--QEIVDLTPLTAKL-RQ-FRQAGDHD----------------KAKRLLPRESIY-RVNNAT--ASRLG-IE-------
    238020853       ---------MT-TPPKQIRA-VYTD-TTIRVYQAYSDAIADTALAAGRF-VSPPFKMER--MTWIKPSFLWMMYRAGW-GGKDDNQKRILAIDISRSGFEWALHHACLSHPPAGMDS---------------------------------------------------ATWQQTKAAH--PVRIQWDPERSLKLEPLPH----RSIQIGLT-GEAVP-RYVNEWI--QNISEITDVVQEI-HA-LIAQDNLA----------------AAQALLPPERVY-PFDWET--DFQAA----------
    239815282       MK-------TDVIPHNQIRA-MYDA-DTIRVYQAYSDAIADSALAQGRL-VSPPFKLER--MTWIKPSFLWMMYRAGW-GLKDEGQKRILAIDITREGFEWALAHSCPSHSPEGMSG---------------------------------------------------EEYAALKQRC--PVRVQWDPERDLHLQPLAH----RAIQIGLS-KEAVR-LYVNEWT--CKITEMTALAHEV-QA-LVQQGQLQ----------------KAASKLPMERAY-PGQQAT-----------------
    254392683       -----------MVALRQIRA-QYDD-RTIVVYQAYSSAIAEPALRAGTF-VPP-FSFGR--MTWIKPSFLWLMHRSNW-ARK-PGQERILAVRITREGWEEALSQAVLTTSHPDRVA-----------------------------------------------------------QA--PVHVQWDPERSLRGAALNH----YSIQVGVG-RGLIE-RYAKEWV--VGITEVTSQARKA-AE-LAQGGRAE----------------KAKRLLPPERPY-PVPRAT--AQRLD-ID-------
    295658070       MDQP-----NVAPTKYAIRA-QYTS-KTITVYQAYSPAIANAALSAGKF-VAP-FKRVR--MTWIKPSFLWMAYRCGW-ATK-KDQERVLAIEITREGFEWALAHACLSHPTPRLYA-------------------------------------------------DHAAWEHRKNES--SVRVQWDPERDFEFRPLEY----RSLQVGLK-EEAVD-RYVDEWT--VGIRDVTWLMQEI-GQ-LVREGKIE----------------EARRKMPVEEVY-VLPTDV--ATVVG-AD-------
    302504024       M--------TDNNPYRAIRA-KFTE-NTITVYQAYSNEIADAALGAGTF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DKSAWESRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GEAVD-QYVDEWI--VSITDITEQIRKV-SG-LVSSGQLG----------------EAKKQMPEECLY-DLPGDV--GEMIG-AS-------
    239606461       MESQQPL--KAGPSNYAIRA-QHTP-TTITIYQAYSPSIANAAVAAGKF-VAP-FKR----MTWIKPSFLWMAYRCGW-ATK-KDQKRVLALEVTREGFHWALAHACLSHPSPHLYA-------------------------------------------------DQATWEKRKEES--PVRVQWDPERDFEFRALEY----RSLQVGLK-GEAVD-RYVDEWI--VGIRDVTGLMREV-GR-LAGEGRLD----------------EAREMMPVEEEY-VLPADV--ARVIG-AD-------
    303312351       M--------SREQGYRAVRA-KFTA-ETITVYQAYSAEIASPALRAGKF-VPP-FKRTR--MTWIKPSFLWMAYRSGW-ASK-PNQERVLAIEISREGFEWALFNSFVNSHDKSLYP-------------------------------------------------DKHAFEHRKQNT--CVRVQWDPERDFGFTPLSY----RSIQIGLS-GEAVD-RYVDEWI--VSIQDVTDRMVKM-GQ-LVAAGKIE----------------EAQKLMPIEEPY-PLPKQV--GAAVG-AS-------
    302657470       M--------TDSNPYRAIRA-KFTE-NTITIYQAYSNEIADAALGAGTF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DKSAWESRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GDAVD-RYVDEWI--VSITDITEQIRKV-SG-LVSSGQLG----------------EAKKQMPEECLY-DLPDDV--GEMIG-AS-------
    326470706       M--------TDNNPYRAIRA-RFTE-NTITVYQAYSNEIADAALGTGTF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DRSAWVLRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GEAVD-RYVDEWI--VSITDITEQVRKV-SG-LVSSGQLD----------------EAKKQMPEECLY-DLPGDV--GEMI-----------
    302411952       DH-------SSPTPPRQIRA-DFDD-TTITLYQAYSAAIAEPAVAAQKLTAAPSFKPTR--MTWVKPSWAWMLYRAGY-SFKDAGQERILALKMRHADFLALLRRGVLASQATTAEG---------------------------------------------------------------EVRVQWDPERTVRLDKLPH----RSIQIGIP-RGLSQ-QWADEWV--VGIEDVTDRARKL-KD-VLDVRPGV-----------SNAELLEMGLVPAERVY-QVPEDV--IRRLC----------
    336117044       ------------PPFRQVRA-VHDE-DTITVYQAYSPAIASAAVAAGGF-VPP-FRRER--MTWIKPSFLWMMYRCGW-ATK-PGQERVLAIRMLRSGFEEALSMASLSHFDPAVYA-------------------------------------------------DQEVWQQRKAAS--PVRVQWDPERDVRLEPLAW----RSLQVGLG-GVAVE-RYVDDWV--VGIEDITAMVEEL-RE-RAPDDRRS--------------------SLPIELPY-PLPPEV--AAVVG-AT-------
    119193120       M--------SREQGYRAVRA-KFTA-ETITVYQAYSAEIASPALRAGKF-VPP-FKRTR--MTWIKPSFLWMAYRSGW-ASK-PNQERVLAIEISREGFEWALFNSFVNSHDKSLYP-------------------------------------------------DKHAFEHRKQNT--CVRVQWDPERDFGFSPLSY----RSIQIGLS-GEAVD-RYVDEWI--VSIQDVTDRMVKM-EQ-LVAAGKIE----------------EAQKLMPIEEPY-PLPKQV--GAAVG-AS-------
    240272965       MEQP-----KTSPSKYAIRA-QYTP-TTITVYQAYSPAIANAAVAAGKF-VPP-FRRGR--MTWIKPSFLWMAYRCGW-ASK-KNQERVLAVEITREGFHWVLAHACLSHPSPRLYV-------------------------------------------------DQATWEKRKDAS--PVRVQWDPERDFEFRPLEY----RSLQVGLK-GEAVD-RYIDEWI--VGIKDVTGLMQDV-GR-LVSEGQLE----------------EAKRRMPVEEEY-VLPEDV--ARIIG-AD-------
    225559493       MEQP-----KTSPSKYAIRA-QYTP-TTITVYQAYSPAIANAAVAAGKF-VPP-FRRGR--MTWIKPSFLWMAYRCGW-ASK-KNQERVLAVEITREGFHWALAHACLSHPSPRLYV-------------------------------------------------DQATWEKQKDSS--PVRVQWDPERDFEFRPLEY----RSLQVGLK-GEAVD-RYIDEWI--VGIKDVTGLMQDV-GR-LVSEGQLE----------------EAKRRMPVEEEY-VLPEDV--ARVIG-AD-------
    342875667       MPTA-----PSTAPYRQVRA-CYND-TTIIVYQAYKESIAKAAVDAQKLNASPDFKSGR--MTWIKPSWAWMMYRAGY-SYKDPGQSRILALRMKHEYFITLLERGVLSSHAHKLNP-----------------------------------------------------GEKRETTV--DVRIQWDPERTAKLEVLPY----RSIQIGIP-GALSK-QWANEWI--VEIEDVTDKAREL-KR-VIDERPGI-----------TDEELLNMGLIFEERPF-EVPEAV--HTKLE----------
    327352957       MESQQPL--KAGPSNYAIRA-QHTP-TTITIYQAYSPSIANAAVAAGKF-VAP-FKRGR--MTWIKPSFLWMAYRCGW-ATK-KDQKRVLALEVTREGFHWALAHACLSHPSPHLYA-------------------------------------------------DQATWEKRKEES--PVRVQWDPERDFEFRALEY----RSLQVGLK-GEAVD-RYVDEWI--VGIRDVTGLMREV-GR-LAGEGRLD----------------EAREMMPVEEEY-VLPADV--ARVIG-AD-------
    296821722       ---------MTDNLYRAIRA-KFTD-DTITVYQAYSDEIADAALGANTF-VSP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDESLYR-------------------------------------------------DKSAWEARMQAS--CVRVQWDPERDFNFTPLNY----RSIQIGLK-GEAVD-RYVDEWI--VSIADATEQIRTV-SR-LVSSGRLS----------------EAGKELPEEKLY-DIPEDV--AKIIG-AS-------
    302922871       TSTSP----DTSIPYHQIRA-HYDG-KTITVYQAYKESIARDAVAAQKLNASPDFKPGR--MTWVKPSWAWMMYRAGY-SYKDSRQSHILAIRMKHEHFIGLLERGVLSKHAKKAPE---------------------------------------------------DSTVKREKTS--DVRIQWDPERTPKLGVLPY----RSIQIGIP-GALST-QWADEWI--FEIEDVTDKAREL-KR-VIDERPDI-----------TEEELLELGLIFEERPF-EVPESV--GERLE----------
    315054759       ---------MADNPYRAIRA-KFTE-NTITVYQAYSNEIADAAMRARTF-VSP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PDQERILAIEITRSGFEWALRNACLSHVDNSLYR-------------------------------------------------DKSAWESRMQSS--CVRVQWDPERDFYFNALSY----RSIQIGLK-GEAVD-RYVDEWI--VSITDVTEQIRKV-SE-LVSSGELG----------------GARKEMPEERLY-GIPEDV--GAMIG-AS-------
    226293790       MDQP-----NVAPTKYSIRA-QYTS-KTITVYQAYPPAIANAALYAGKF-VAP-FKRRR--MTWIKPSFLWMAYRCGW-ATK-KDQERVLAIEIAREGFEWALAHACLSHPTPRLYA-------------------------------------------------DHAAWELRKNES--PVRVQWDPERDFEFRPLEY----RSLQVGLK-EEAVD-RYVDEWT--VGIRDVTGLMQEI-GQ-LVGEGKIE----------------EARRKMPVEEVY-VLPTDV--ATVVG-AD-------
    327308048       M--------TDNNPYRAIRA-KFTE-NTITIYQAYSNEIADAALGAGAF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DKSPWESRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GEAVD-RYVDEWI--VSITDITEQIRKV-SD-LVSSGQLG----------------EAKKQMPEKCLY-DLPGNV--GEMIG-AS-------
    225684169       MDQP-----NVAPTKYSIRA-QYTS-KTITVYQAYPPAIANAALYAGKF-VAP-FKRRR--MTWIKPSFLWMAYRCGW-ATK-KDQERVLAIEIAREGFEWALAHACLSHPTPRLYA-------------------------------------------------DHAAWERRKNES--PVRVQWDPERDFEFRPLEY----RSLQVGLK-EEAVD-RYVDEWT--VGIRDVTGLMQEI-GQ-LVGEGKIE----------------EARRKMPVEEAY-VLPTDV--ATVVG-AD-------
    315506327       ------------VPRHQIRA-AYTG-TAVTVYQAYPPEIADAALRAGRF-VPP-FKRER--MTWIKPSFRWMMYRCGW-ALK-PCQERVLAVDISRAGFEWALRHACLSSYDPRLHP-------------------------------------------------DRDAWRHSLRVS--PVRVQWDPERSLRLAPLPY----RSLQVGLT-GDAVR-RYVDEWV--VGLTDVTGLARSV-HG-RLTDGDEA----------------GAAALLPVERLY-PLPAEVA--RVVD-AG-------
    302867267       ------------VPRHQIRA-AYTG-TAVTVYQAYPPEIADAALRAGRF-VPP-FKRER--MTWIKPSFRWMMYRCGW-ALK-PCQERVLAVDISRAGFEWALRHACLSSYDPRLHP-------------------------------------------------DRDAWRHSLRVS--PVRVQWDPERSLRLAPLPY----RSLQVGLT-GDAVR-RYVDEWV--VGLTDVTGLARSV-HG-RLTDGDEA----------------GAAALLPVERPY-PLPAEVA--RVVD-AG-------
    258574383       M--------STSHPYRAIRA-KFTP-DTITVYQAYSAEIALPAVRAGKF-VAP-FKRTR--MTWIKPSFLWMAYRSGW-ASK-PNQERILAIEISRAGFEWALLNSFVNTHDPAFYG-------------------------------------------------DHRALEERKRNT--CVRVQWDPERDFGFEPLPY----RSIQVGLS-GEAVE-RYVDEWI--VAIEDVTELMVGM-GR-LVAEGKIE----------------EARELMPVEKAY-PLPEEVA--KVVG-AS-------
    310796940       GH-------RPPTPFRQIRA-RFDE-ESITVYQAYNSAIAAAAVEAQRLDASPGFKVTR--MTWIKPSWAWMMYRAGY-SFKDPGRERILALKMRHGDFVDLLRKGVVARRGNESRD-----------------------------------------------------------GR--GVRIQWDPERDVRLGRLQR----RSIQIGTP-----------------------PRYLEL-KR-VLEERPGV-----------GDGELIDLGLLPAEKEF-EVPKDVE--ELLE-MN-------
    269121733       --------------MRKINA-LYDD-DTVRVYQAYRNEIADEALELGTF-GSH-FKRTR--MTWIKPSFLWMMYRAGW-AEK-EGQERILAIDITKDGFLTILKNSVLSHYDRKVYE-------------------------------------------------KAEEWELDKRNF--SGRCQWDPERNIFGSPLEF----RAIQLGLK-DEIVE-SYIKKWI--VNIEDITPMVRKI-KK-MRDEGKDI------------------KEYLPVEKELRIEDSEVI--KRLR-ID-------
    290961991       PTEDL----APTEPKFRIRA-RHTT-DTITVYQAYRPEIGGPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GMK-EGQETVLAVEIGREGFEWALRHACLSHFVPELHT-------------------------------------------------DQAEWKRRLRRA--PARVQWDPERSLRLGPLPY----RSLQLGLV-GEAAA-RYADEWI--VGIEDVTPLAREV-HG-HVRAGALD----------------RAAALLPQEPPY-PVAEDVL--AHLR----------
    294628199       MNDHH----AEAEPRFRIRA-RHTD-TTVTVYQAYRPQIGGPAARTGRF-PAD-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAVEIRRDGFEWALRNACLSHHVPALHG-------------------------------------------------DQASWRRRLREA--PARVQWDPERDLHHNPLPY----RSLQLGLA-GPAAA-RYADEWI--TGIEDVTPLAAEI-HA-LVRTGELE----------------RATALLPKERPY-PVADEVL--AHLR-A--------
    302549980       MN-------DRNEPRFRVRA-RHTE-STITVYQAYRPEIGGPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAVEISRDGFLWALRNACLSHHVPALHG-------------------------------------------------EQADWKRQLRRA--PARVQWDPERDLRLAPLPY----RSLQLGLA-GEAAA-RYADEWI--VGIEDVTPLATEV-HA-LVRAGELD----------------AAAGLLPEERPF-HVDDEVL--ARLG-AR-------
    300774505       KEQLL----EWPQQGYHIMA-QYDD-EKIIVYQSYRKEIGEFAVKNQFF-GGG-FSLER--MTWIKPNFLWMMYRNGW-GKK-EGQECVLAIHLKKEAFKNYLENAVYSSYNKKLGI-------------------------------------------------SREEWQDQIKES--SVRLQWDPDHDPFGNKLER----RAIQIGLR-NEFTR-SFAKDDI--ILIKNISDFVKEQ-YQ-FVLNDDLD------------------NLIVPEEKPL-LFD-EVL-NKKLN-LR-------
    320010749       MND------RTGPPRHEIRA-RHTD-STVTVYQAYRPAIGLAAARDGRF-PSE-WKRDR--MTWIKPSFLWMMYRCGW-GAK-EGQETVLAVEISREGFGWALENAELSHYVRGVHA-------------------------------------------------DRATWQRDLRRR--PTRVQWDPERDLHLNALPH----RSLQLGLS-GEAAR-RYADEWL--VSVTDVTPLAHEI-HA-LVRAGETD----------------RASALLPVEEPLTGLQAPVP-ADR------------
    298248426       LTQRE----NWPDEGRHILA-QYDE-QSVVVYQAFKPTIGRFAAMHGFF-GGG-FRLDR--TSWVKTNFLWMMYRSQW-GTV-PQQEIVLAVFLKRDAFDWLLSQAVHSLYHADLYP-------------------------------------------------SDTAWYAQLRRS--PVVLQWDPDHAPTGHRLSR----SAIQLGLR-GEALA-KYAREWI--VAIEDISDFVAQQ-RL-FVQTKAFE------------------QLQVPYETVY-PVADPVV-AARLL-LA-------
    299472531       LFSEAKA--HWAAPYRQVFC-QHDK-DTVVLFRACCEHLGPHATATQCFRGSPCYEKDRTRMMWFDSSFLVSMRKSEW-GTK-KGREVVLAIWVKRSFIEDCFGMAVCSNTFGPSCGGGGGGNGSSGGRKGSGGIGRRSSFAVTPFPTSDSGGDDGRSPPTSGFPTPVNSVAGSPPASPVSGQQHQRREQEATASESE---GGRASG-----GDGAR-DDARRAA--AAAATSTALLSKG-QA-SLAQGNEN---------------DEDDDNIPRGRAVTGDPSTRY---YFG-GSAGDPLG-
    271967482       ----------MNMPHRQIRA-AYTE-KSITVYQAYDPAVAEPAVAAQRF-VAP-FKRER--MTWIKPSFLWMMYRCGY-ATK-PGQTRVLAIDLTRAGFEWALAHSCLSHPGRDGDQ---------------------------------------------------ETWKERLRHS--PVRVQWDPERDPHHNALPH----RSIQIGLS-GQAVD-RYLDDWT--VSITDITDRVRDV-HT-ALRDGR------------------DVTALLPPERPY-PVPVELA--RTIG-ATAGGDAG-
    consensus/90%   .................lbA...s..psl.lYQAa.s.lu..Ah....hs....ap..R..MoWlKPsahWhhaRssa.u.K...Qp.lLAlclp+..a..hL.puh.sp.......................................................................s.hQWDP-+s.....l......RulQlGl.........a.pph.....lpDlo..h........h..........................bhP.Ep.h........................
    consensus/85%   .................lbA..as..psl.VYQAY.s.Iu..Ah...pFs.s..ap..R..MoWlKPsFhWhhaRssa.u.K..sQp.lLAlclp+.sa..hL.puh.op............................................................b..........s+lQWDP-+s.....l......RulQlGl....h...paspch.....lpDlT.bhpp......l..........................bhP.Ep.a........................
    consensus/80%   ................pIbA..as..pol.VYQAYps.Iu..Ah...pFs.ss.apbpR..MTWIKPSFhWMhYRsGW.u.K..sQcplLAlclpRpsFc.hL.puh.op............................................................hp.....s...s+lQWDP-+s.....L......RulQlGl..sphhp.pasp-W...h.IpDlTsbhpph.....l..........................bhP.Ep.a..hs....................
    consensus/75%   .............s.ppIbA..as..pol.VYQAYps.Iu..Ah...pFs.ss.apbpR..MTWIKPSFLWMhYRsGW.u.K..sQEplLAlclpRpuF-.hL.puhlSp........................................................s...Wp..bp.u..slRlQWDPERshp.p.L......RulQlGlp.sphhp.pasp-Wh..lsIpDlTsbhpch.p..hl..sp......................hlP.Ep.Y..hs....................
    consensus/70%   h............s.+pI+A..as..pTlsVYQAYps.IupsAlp..pFs.ss.FpbsR..MTWIKPSFLWMMYRsGW.upK..sQEplLAlcIpRpuF-bhL.puhlSp....h...................................................sp..Wpp.bppu..sVRlQWDPERshp.psLsb....RolQlGlp.uphhc.cYsp-Wl..lsIpDlTsbhcch.p..hlppsp.p....................hlP.EpsY..ls.......h............
    consensus/100%  ......................................................................................................h.................................................................................pb..................s...G...............................................................................................
    consensus/95%   .................lbu...s....l.lYQAa...lu..Ah....hs....a...R...oWlKssa.Whh.Rssa.u.K...Qp.lLul.h.+..h..hl..s..s..........................................................................hQWDP-+......h......bulQlGl.........a.pp......l.-ho..h.....................................s.E..h........................

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Multiple Sequence Alignment of the RNxxxH family

This domain is found close to a PARP gene in our operons and may be associated with NAD or ADP-ribose processing

    ALIGN	        -----------H-HHHHHHHHHHHHHH--------------HHHHHH-HHHHHHHHH---------------------------------------------------------------------------H-HHH---HHHHHHHHHH---EEEE-------HHEEEEEE-------------EEEE-----H--------HHHHHHHHHHHH---
    HMM	        ---------HHHHHHHHHHHHHHHHHH---------------HHHHH-HHHHHHHHHHHHHHH------------------------------------------------------EEEE-----------HHHHH---HHHHHHHHHH---EEEEE-----EEEEEEEEEE------E----EEEEEEEHHHH--------HHHHHHHHHHH----
    FREQ	        ------------HHHHHHHHHHHHHH---------------HHHHHH-HHHHHHHHHHHHH----------------------------------------------------------------------HHHHHH---HHHHH--------EEEEE----HHHHHHHHEHH-----------EEEEEE-H-----------HHHHHHHHHHHHH--
    PSSM	        -----------HHHHHHHHHHHHHHHHH---------------HHHH-HHHHHHHHHHHHHHH------------------------------H--------------------------------------HHHHH---HHHHHH-------EEEEE-------EEEEEEEE-----------EEEEEEE-HHH--------HHHHHHHHHHH----
    FINAL	        -----------HHHHHHHHHHHHHHHH---------------HHHHH-HHHHHHHHHHHHHHH--------------------------------------------------------------------HHHHHH---HHHHHH-------EEEEE-----EEEEEEEEEE-----------EEEEEEEHHHH--------HHHHHHHHHHHH---
    167753772       -----MEYKNIFEIEFIQRTQEIVNGYQ-----------IPFENTLF-INACVGLLIIPQQSL------------------------------FNHLPTEVVS--------AD---KWGIADTDISCIKEPNKSVKN---VARHIRNAIAHDGIRFGSDNGKDITHIKITDWKDERHKTE----TFKAVIEVTKF--------KTFVWAFAQFALTQQ
    206575484       -----MGNYSDFETEFVQRTLALIDQYNEMIKELGKPFREQYNYTLT-LNCLLGLIVMPKERA------------------------------LSFLPAERLT--------QQLKTSMGLQESQLP---GPEMTLRA---LILKMRNSVAHFSVQVVSVSDERL--VDLIAFRDDPEDEN----AY-ATFSAPEL--------LPFLKYYASLLLNNM
    209544855       -----MGIPSDPLLDIMRRSLINLDFIEANYQDHGL-----YEVTQL-VNTFLGAFIHPFEKSAKGKEF------------------------ISYFRARPPP--------VPFAAKT-----------AEDFNYLE---FIYFVRHALAHGDLHYNANKIKQI--ESITLWNSKYGEKA----IR-ITLSIRDM--------RVLLLDFKNILEKMF
    209921977       -----MGNYSDFETDFIERTLALIDQYNNMIE--GKPFPEQYNYTLT-LNCLLGLIVMPRERA------------------------------VSYLPSDRLT--------PELKAEIGLNESQLP---GEEMNLRE---LIHKMRNSVAHFCVQVESISDARL--VDQIIFKETHGAGR----AY-AIFSAPEL--------LPFLKYYAALLIANM
    217979676       -----MGMPTEPLLVIMRRSMANLAFVETHAGPAGP-----YEVTQL-INTFLGALAHPFEAM------------------------------RDDLMALPLA--------DAAVLGWPTINKERPSD-REPASLGD---LIRLMRNGMAHGNLDYLSDGKGQI--HALRVWNTHPRTGAR---TWGTVVPIADV--------RRFLGLFVDLIERRH
    225181269       -----MER-QVVEKDFVARTMHILENYD------GP-----YGVTLL-INCLLGLIVLPRERGFNR---------------------------VCHQEGIGFS--------DLGIDPQEICWGRIA---EQEQTASR---FLQCMRNSVAHIKIESISEQGE-I---ESLRFKDQSGFE--------VVMKIEKV--------KELATKLAQYVQ---
    228923828       -NISLLWIQECFKPDNQDRKLKDVLSEFITIND-NIN--LYNNPGMLLMASYL-FFVYAKE---------------------------------KDFIGRDYS--------FADTSKFEVLECEKE---KRDSNY-----ICRRIRNALAHSRVHIGE--NGLI------TFEDFKPEGTKRLDYFKCTISYTDF--------GNFISAFYHGVKDRY
    229175166       -NISLLWIQECLKPENQNKKVNELLREFLNKNE-NIN---LLNPSVLLMASYL-LFVYTKE---------------------------------KDFNDGDYS--------FVDISKFNVIASRKR---RPDGNY-----ICRRVRNALAHSRVHIDE--SLQI------TFEDSKPDGT---DYFKCVISCVDF--------GNFINNFMFTLKDSY
    238916184       SENVTQNEIEKYKKQLEKSLLELREDKNAKISFK-----IGFVYLYA-MNFALRTEDDDYEELK-----------------------------YQELNVSKFK--------YQKENWIQYSQRNKT---QNCLFPRY---IVERMRNSLMHGNIEILLNNKGKI----EFIFRDKYNKRD----EV-ISIILEDL--------EEFLSQKCLYTGIPK
    239908249       -------MYTHLHHDFAAKTRANLEFIEKACME-GIP--GTYNATQL-INSLLGMVVFLNEGKL-----------------------------VPAIPFSQLC--------SCEEIQVHLDDN------QDCSKADK---FIQQFRNAIAHCRFQAFG-SKDNI--QSFTMYDQRPKEPI----DWKIDITTQGI--------RDIAFRLVAYVIKNS
    256367844       -----MGNYSDFETDFVQRTLALIDQYNEMIEVLGKPFREQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLPADRLT--------RQLKAEMGLHESQLP---GPEMNLRE---LIHKMRNSVAHFCVQVESASDAHL--VDWIVFRESQEDGE----VY-ASFSAPEL--------LPFLKYYATLLLDNM
    270293299       -IEDVSPEKTQNQIKEINKSIRELKEDEDKIV--------GFNFMFP-VLRLLDISLRLEDDD------------------------------LKKISPLSVNIDGFTYEEDNLQKYYQNNSSTINK--RSETKYYY---ILERIRNAIAHGHITTYLDSNSNI----VYKLEDIWNNR--------TEKVEIDY--------DSMINFLEQPIFTER
    283783211       RIIDYKIAIDSKKAKMIDRILKSIDELKEDSDSWIE-FRWFFKIIYI-INFSLRLEDTDLESIK-----------------------------YSVLNVDDFEYDSSQ---MALFVKKKISDGTIR---SRDEKFGNTIYILHKIRNAIAHGRIKLEVIDDKVY-----YVFEDCYYKRT----EL-IKIAVENM--------NQFINNVNALIK---
    291288929       -----MGNYSDFETDFVQRTLALIDQYNEMIEELGKPFSEQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLPADRLT--------RQLKAEMGLHESQLP---GPEMNLRQ---LIHKMRNSVAHFCVQVESVSDAHL--VDWIVFRESQGDGD----VY-ASFSAPEL--------LPFLKYYATLLLDNI
    313682815       -MGHYPEEKSEFIREFFKRTLHNLHIYLEDQQ--NSKFRYPYDVTQT-INSFLGLIVFLQDSDI-----------------------------VFTQELEDFVE-------AHLPIQWTCFDGNNG---LEEHNFRN---YLKRLRNAVSHRKIKSIPDQNNEI---MALEFRDGKNGG-----CFCAKLSVESV--------NLLITLLSRNILGAQ
    329996741       -----MGNYSDFETDFVQRTLALIDQYNEMIEVQGKPFREQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLPADRLT--------LQLKAEMGLHESQLP---GPEMTLRT---LILKMRNSVAHFSVQVISVSDEHL--VDLIAFRDDPEDEN----AY-ATFSAPEL--------LPFLKYYAAQLLGNM
    333378220       -------SIQYFDISFIERTLENLKKYEGK-----------YDFTML-LNSLLGLLVVPNEYNIAKKRRFKYPFLNEKISKFSSIKEIFKNKSYSFLDKDKKEI-------NQYKFRWLDDNKNVLT--INNITLES---FLRRIRNGIAHFGITPVKEDSLWIG-IIIRNYKNREMNME-------VYFEEDEL--------RTFALFIAEKYLETV
    58383293        -----MGNYSDFETDFVQRTLALIDQYNEMIEVLGKPFREQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLLADRLT--------RQLKAEMGLHESQLP---GPEMNLRE---LIHKMRNSVAHFCVQVESASDAHL--VDWIVFRESQKDGE----VY-ASFSAPEL--------LPFLKYYATLLLDNM
    78223734        -----QEYFRDFMVE-LNHAFLHLTEINQFDWHDQLDTSDNYELTRFIDQNIHPTYLRLIEAVYSPMLRI-----------------------PAYFSRLKRGKG------TEKLDVFNIVEELKT---SDLNELTVH--YRHVVRNGIAHGGIKFF---DNSI------SYKDKQRNED----VL-SDRTMVNVCDNIIDTCNAIVLAFSVFVIANQ
    91203343        ------MDYKQIVRDFAQRTKILINEYKGD-----------YEVTLL-VNCCLGLLVVPKEID------------------------------FKKIPVEVIPE-------KDTLWGLSRESVSVKCK-ECSYVLRD---VIKKIRNGICHFDITSIPDENNQI---EFLVIKDRGGFE--------AKLSVAQL--------KELAISLTDHVYKP-
    consensus/100%  .........p........p.........................................p...................................b...........................................h...hRpuh.H..hp........h.......hpp....................h..........hh...........
    consensus/95%   .........p....p...+.b..l.................h...b..h..hl.......-...................................b.....................................h.....hh..hRNulsH..lp........l.......hpp...............b...ph..........hh..h...hb...
    consensus/90%   .........p....p..p+.b..l..b..............ap..b..hs.hL.hbh..b-...................................h....................b.............p.ph.....hh..hRNuluH..lp........l.......acp...............h...ph..........hh..h...hb...
    consensus/85%   ........bpp.b.cbhp+ph..lp.bp.............aphsb..hsshL.hhl..bE.................................p.h....hs..............h...p.p.......p.ph.....hhpbhRNulAH.plp.....p..l.......acpp............h.h.h.ph..........hh..h...lb...
    consensus/80%   ........bpphb.chhp+sh..lpbhp.............aphob..lNshLshhl.sbE................................hp.h.s..hs..............h...p.p.......p.ph.....hlpbhRNulAH.plp....ps.pl.......ac-p..p.........h.hsh.ph..........hl..hs..lb...
    consensus/75%   .....b..bpphb.-hhpRoh..lpbhp.............aphTh..lNshLshhl.sbE................................hp.h.spphs...........b.bh.h.pspb......p.sh.....hlc+hRNulAH.plph...ps.pl.......ac-p..p.......h.h.hsh.ch..........hl..hs.blb...
    consensus/70%   .....b..bpphc.-hhpRol..lcbhp.............YshTh..lNshLGlhlhsbE................................hs.lsspphs.........pbb.bh.h.pspb......p.shpp...llc+hRNulAH.plphbs.ps.pl.....b.ac-p..p.......h.hshsh.cl........bshl..hs.blb.pb

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Phylogenetic tree of the sirtuins

Eukariotic branches are colored blue, Archaeal branches are red and bacterial branches are green.

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Supplementary table S1: organism identifiers used in this work.

Organism Code | Scientific Name
--- | ---
Aaeg | Aedes aegypti
Abau | Acinetobacter baumannii
Aben | Arthroderma benhamiae
Abip | Asticcacaulis biprosthecum
Aboo | Aciduliprofundum boonei
Acal | Acinetobacter calcoaceticus
Acap | Ajellomyces capsulatus
Acar | Anolis carolinensis
Acel | Acetivibrio cellulolyticus
Acit | Acidovorax citrulli
Acla | Aspergillus clavatus
Acol | Anaerotruncus colihominis
Ader | Ajellomyces dermatitidis
Afla | Aspergillus flavus
Afum | Aspergillus fumigatus
Agos | Ashbya gossypii
Agyp | Arthroderma gypseum
Alai | Albugo laibachii
Alon | Acetonema longum
Aman | Aurantimonas manganoxydans
Amar | Acaryochloris marina
Amax | Arthrospira maxima
Amed | Amycolatopsis mediterranei
Amir | Actinosynnema mirum
Aory | Aspergillus oryzae
Aota | Arthroderma otae
Aput | Alistipes putredinis
Aque | Amphimedon queenslandica
Asp. | Actinomyces sp.
Ater | Aspergillus terreus
Aven | Archaeoglobus veneficus
Avin | Allochromatium vinosum
BP0305phi8-36 | Bacillus phage 0305phi8-36
BP1 | Roseovarius sp. 217 phage 1
BPSP18 | Shigella phage SP18
BPphiAS5 | Aeromonas phage phiAS5
BPphiEF24C | Enterococcus phage phiEF24C
Bado | Bifidobacterium adolescentis
Bamb | Burkholderia ambifaria
Bbre | Brevibacillus brevis
Bcel | Bacillus cellulosilyticus
Bcen | Burkholderia cenocepacia
Bfra | Bacteroides fragilis
Bfuc | Botryotinia fuckeliana
Bgla | Burkholderia gladioli
Bhyo | Brachyspira hyodysenteriae
Blat | Brevibacillus laterosporus
Bmar | Bacteriovorax marinus
Bmar | Bermanella marisrubri
Bmar | Blastopirellula marina
Bmur | Brachyspira murdochii
Bpar | Bordetella parapertussis
Bpse | Burkholderia pseudomallei
Bsp. | Bacillus sp.
Bsub | Brevundimonas subvibrioides
Bthu | Bacillus thuringiensis
Bubo | Burkholderia ubonensis
Bvie | Burkholderia vietnamiensis
Bxyl | Bacteroides xylanisolvens
CAcc | Candidatus Accumulibacter
CKor | Candidatus Koribacter
CKue | Candidatus Kuenenia
CPor | Candidatus Poribacteria
Caci | Catenulispora acidiphila
Casp | Clostridium asparagiforme
Cbac | Clostridiales bacterium
Cbei | Clostridium beijerinckii
Cbes | Caldicellulosiruptor bescii
Cbol | Clostridium bolteae
Ccon | Campylobacter concisus
Cdif | Clostridium difficile
Cdub | Candida dubliniensis
Ceut | Coprococcus eutactus
Cfim | Cellulomonas fimi
Cfla | Cellulomonas flavigena
Cfla | Chthoniobacter flavus
Cgin | Capnocytophaga gingivalis
Cgla | Candida glabrata
Cgle | Chryseobacterium gleum
Cglo | Chaetomium globosum
Cgra | Campylobacter gracilis
Chir | Clostridium hiranonis
Chom | Cardiobacterium hominis
Cimm | Coccidioides immitis
Clju | Clostridium ljungdahlii
Clus | Clavispora lusitaniae
Cmat | Corynebacterium matruchotii
Cmil | Cordyceps militaris
Cmit | Catenibacterium mitsuokai
Coch | Capnocytophaga ochracea
Cowc | Capsaspora owczarzaki
Cpin | Chitinophaga pinensis
Cpos | Coccidioides posadasii
CrVB | Cafeteria roenbergensis virus BV-PW1
Cram | Clostridium ramosum
Crem | Caenorhabditis remanei
Csp. | Capnocytophaga sp.
Csp. | Carnobacterium sp.
Csp. | Coprobacillus sp.
Csp. | Coprococcus sp.
Csp. | Cyanothece sp.
Cspu | Capnocytophaga sputigena
Ctes | Comamonas testosteroni
Cvar | Chlorella variabilis
Cvio | Chromobacterium violaceum
Cyou | Citrobacter youngae
Dace | Desulfobacca acetoxidans
Daci | Delftia acidovorans
Dalk | Desulfatibacillum alkenivorans
Dalk | Dethiobacter alkaliphilus
Dbaa | Desulfarculus baarsii
Ddes | Deinococcus deserti
Dfas | Dictyostelium fasciculatum
Dfor | Dorea formicigenerans
Dgad | Dysgonomonas gadei
Dgri | Drosophila grimshawi
Dhan | Debaryomyces hansenii
Dmag | Desulfovibrio magneticus
Dmar | Deinococcus maricopensis
Dmos | Dysgonomonas mossii
Dole | Desulfococcus oleovorans
Dpro | Deinococcus proteolyticus
Dpro | delta proteobacterium
Drer | Danio rerio
Dsp. | Delftia sp.
Dsp. | Dermacoccus sp.
Dsp. | Desmospora sp.
Dzea | Dickeya zeae
Eaer | Enhydrobacter aerosaccus
Eaer | Enterobacter aerogenes
Ecor | Eikenella corrodens
Edis | Entamoeba dispar
Eeli | Eubacterium eligens
Efer | Escherichia fergusonii
Eict | Edwardsiella ictaluri
Esab | Eubacterium saburreum
Esir | Eubacterium siraeum
Esp. | Erythrobacter sp.
Esp. | Escherichia sp.
Etar | Edwardsiella tarda
Faln | Frankia alni
Fjoh | Flavobacterium johnsoniae
Foxy | Fusarium oxysporum
Fper | Fusobacterium periodonticum
Fpla | Ferroglobus placidus
Fpra | Faecalibacterium prausnitzii
Fpsy | Flavobacterium psychrophilum
Fsp. | Frankia sp.
Fsp. | Fusobacterium sp.
Fsuc | Fibrobacter succinogenes
Gbem | Geobacter bemidjiensis
Gdia | Gluconacetobacter diazotrophicus
Ggra | Glomerella graminicola
Ghan | Gluconacetobacter hansenii
Glov | Geobacter lovleyi
Gmax | Glycine max
Gobs | Gemmata obscuriglobus
Gobs | Geodermatophilus obscurus
Gpro | gamma proteobacterium
Gvag | Gardnerella vaginalis
Haur | Herpetosiphon aurantiacus
Hbut | Hyperthermus butylicus
Hche | Hahella chejuensis
Hfil | Holdemania filiformis
Hhyd | Halanaerobium hydrogeniformans
Hhyd | Haliscomenobacter hydrossis
Hmar | Haloarcula marismortui
Hoch | Haliangium ochraceum
Htur | Haloterrigena turkmenica
Hwin | Helicobacter winghamensis
Iagg | Ignisphaera aggregans
Ihos | Ignicoccus hospitalis
IiV6 | Invertebrate iridescent virus 6
Ipol | Ilyobacter polytropus
Jsp. | Jannaschia sp.
Kalg | Kordia algicida
Kfla | Kribbella flavida
Klac | Kluyveromyces lactis
Kora | Kingella oralis
Kpas | Komagataella pastoris
Kpne | Klebsiella pneumoniae
Krac | Ktedonobacter racemifer
Kset | Kitasatospora setae
Ksp. | Klebsiella sp.
LV | Lausannevirus
Lagg | Labrenzia aggregata
Lbac | Lachnospiraceae bacterium
Lbic | Laccaria bicolor
Lbra | Leishmania braziliensis
Lbre | Lactobacillus brevis
Lbuc | Leptotrichia buccalis
Lelo | Lodderomyces elongisporus
Lgoo | Leptotrichia goodfellowii
Lhof | Leptotrichia hofstadii
Linf | Leishmania infantum
Lmac | Leptosphaeria maculans
Lsp. | Lyngbya sp.
Lthe | Lachancea thermotolerans
Lult | Lactobacillus ultunensis
MV | Marseillevirus
Macr | Metarhizium acridum
Mact | marine actinobacterium
Madh | Marinobacter adhaerens
Mani | Metarhizium anisopliae
Maur | Micromonospora aurantiaca
Mcht | Microcoleus chthonoplastes
Mcon | Methanosaeta concilii
Mext | Methylobacterium extorquens
Mful | Myxococcus fulvus
Mgam | marine gamma
Mglo | Malassezia globosa
Mgui | Meyerozyma guilliermondii
Mkan | Methanopyrus kandleri
Mlar | Melampsora larici-populina
Mmah | Methanohalophilus mahii
Mmar | Microscilla marina
Mmet | Methylomonas methanica
Mmul | Macaca mulatta
Mory | Magnaporthe oryzae
Mpal | Mucilaginibacter paludis
Mpet | Methylibium petroleiphilum
Mpho | Microlunatus phosphovorus
Mrum | Methanobrevibacter ruminantium
Msil | Methylocella silvestris
Msp. | Marinobacter sp.
Msp. | Micromonas sp.
Msp. | Micromonospora sp.
Msp. | Moritella sp.
Msta | Methanosphaera stadtmanae
Mthe | Methanosaeta thermophila
Mtri | Methylosinus trichosporium
Mtun | Methylobacter tundripaludum
Mvag | Microcoleus vaginatus
Mzhi | Methanosalsum zhilinae
Nabi | Neodiprion abietis
Nbac | Nocardioidaceae bacterium
Ndas | Nocardiopsis dassonvillei
Nelo | Neisseria elongata
Nfis | Neosartorya fischeri
Nfla | Neisseria flavescens
Nhae | Nectria haematococca
Nhal | Nitrosococcus halophilus
Nmar | Nitrosopumilus maritimus
Nmul | Nakamurella multipartita
Nspu | Nodularia spumigena
Nsub | Neisseria subflava
Ntet | Neurospora tetrasperma
Nvit | Nasonia vitripennis
Oant | Octadecabacter antarcticus
Obat | Oceanicola batsensis
Oluc | Ostreococcus lucimarinus
Omor | Osmerus mordax
Osp. | Oribacterium sp.
Osp. | Oscillatoria sp.
Oter | Opitutus terrae
Otri | Oscillochloris trichoides
Pans | Podospora anserina
Parc | Psychrobacter arcticus
Pars | Pyrobaculum arsenaticum
Pbra | Paracoccidioides brasiliensis
Pbra | Planctomyces brasiliensis
Pcal | Pyrobaculum calidifontis
Pcap | Pseudoflavonifractor capillosus
Pcar | Pectobacterium carotovorum
Pchr | Penicillium chrysogenum
Pcry | Psychrobacter cryohalolentis
Pcur | Paenibacillus curdlanolyticus
Pent | Pseudomonas entomophila
Pgra | Puccinia graminis
Pisl | Pyrobaculum islandicum
Plav | Parvibaculum lavamentivorans
Plim | Planctomyces limnophilus
Pmar | Penicillium marneffei
Pmar | Perkinsus marinus
Pmar | Planctomyces maris
Pmen | Pseudomonas mendocina
Pmir | Proteus mirabilis
Pori | Prevotella oris
Ppac | Plesiocystis pacifica
Ppal | Polysphondylium pallidum
Ppar | Pedosphaera parvula
Ppen | Proteus penneri
Ppol | Paenibacillus polymyxa
Prum | Prevotella ruminicola
Prus | Providencia rustigianii
Psit | Picea sitchensis
Psp. | Paenibacillus sp.
Psp. | Psychrobacter sp.
Psp. | Pusillimonas sp.
Psuc | Phascolarctobacterium succinatutens
Psyr | Pseudomonas syringae
Ptim | Prevotella timonensis
Ptor | Psychroflexus torquis
Ptri | Pyrenophora tritici-repentis
Pver | Prevotella veroralis
Ralb | Ruminococcus albus
Rbal | Rhodopirellula baltica
Rbro | Raphidiopsis brookii
Rcas | Roseiflexus castenholzii
Rden | Rothia dentocariosa
Retl | Rhizobium etli
Rfla | Ruminococcus flavefaciens
Rgna | Ruminococcus gnavus
Rint | Roseburia intestinalis
Rleg | Rhizobium leguminosarum
Rpic | Ralstonia pickettii
Rsli | Runella slithyformis
Rsp. | Rahnella sp.
Rsp. | Roseibium sp.
Rsp. | Roseiflexus sp.
Rsp. | Roseobacter sp.
Rsp. | Ruegeria sp.
Salb | Streptomyces albus
Sare | Salinispora arenicola
Saur | Stigmatella aurantiaca
Sbin | Streptomyces bingchenggensis
Scar | Staphylococcus carnosus
Scel | Sorangium cellulosum
Scla | Streptomyces clavuligerus
Scom | Schizophyllum commune
Sdeg | Saccharophagus degradans
Sfla | Streptomyces flavogriseus
Sfum | Syntrophobacter fumaroxidans
Sgha | Streptomyces ghanaensis
Sgri | Streptomyces griseoaurantiacus
Sgri | Streptomyces griseoflavus
Sgri | Streptomyces griseus
Shel | Slackia heliotrinireducens
Shim | Streptomyces himastatinicus
Sinv | Solenopsis invicta
Sjap | Schistosoma japonicum
Sjap | Schizosaccharomyces japonicus
Skow | Saccoglossus kowalevskii
Skuj | Sulfuricurvum kujiense
Slac | Serpula lacrymans
Slin | Spirosoma linguale
Slip | Syntrophothermus lipocalidus
Sliv | Streptomyces lividans
Smar | Staphylothermus marinus
Snas | Stackebrandtia nassauensis
Spar | Streptococcus parasanguinis
Spri | Streptomyces pristinaespiralis
Sput | Shewanella putrefaciens
Sros | Streptomyces roseosporus
Sros | Streptosporangium roseum
Ssan | Streptococcus sanguinis
Ssat | Shuttleworthia satelles
Ssca | Streptomyces scabiei
Sscl | Sclerotinia sclerotiorum
Ssp. | Salpingoeca sp.
Ssp. | Sphingomonas sp.
Ssp. | Streptococcus sp.
Ssp. | Streptomyces sp.
Ssti | Scheffersomyces stipitis
Ssvi | Streptomyces sviceus
Ster | Sebaldella termitidis
Stro | Salinispora tropica
Sven | Streptomyces venezuelae
Svio | Streptomyces violaceusniger
Svir | Streptomyces viridochromogenes
Taqu | Thermus aquaticus
Tbac | Thermotogales bacterium
Tbar | Thermococcus barophilus
Tbru | Trypanosoma brucei
Tcas | Tribolium castaneum
Tcur | Thermomonospora curvata
Tden | Thiobacillus denitrificans
Tmel | Tuber melanosporum
Tree | Trichoderma reesei
Trub | Trichophyton rubrum
Tsp. | Thauera sp.
Tsti | Talaromyces stipitatus
Tsul | Thioalkalivibrio sulfidophilus
Tthe | Tetrahymena thermophila
Tton | Trichophyton tonsurans
Ttur | Teredinibacter turnerae
Tvag | Trichomonas vaginalis
Tver | Trichophyton verrucosum
UDes | uncultured Desulfobacterium
Umet | uncultured methanogenic
Uree | Uncinocarpus reesii
Valb | Verticillium albo-atrum
Vbac | Vibrionales bacterium
Vdis | Vulcanisaeta distributa
Vhar | Vibrio harveyi
Vmar | Verrucosispora maris
Vpar | Variovorax paradoxus
Vpol | Vanderwaltozyma polyspora
Vspi | Verrucomicrobium spinosum
Vspl | Vibrio splendidus
X(Si | Xenopus (Silurana)
Xfus | Xanthomonas fuscans
Xnem | Xenorhabdus nematophila
Xper | Xanthomonas perforans
Xves | Xanthomonas vesicatoria
Ylip | Yarrowia lipolytica
Zmob | Zymomonas mobilis
Zrou | Zygosaccharomyces rouxii

Back to Contents

Supplementary table S2: sequence accession numbers.

gi | accession | identifier
--- | --- | ---
153817467 | ZP_01970134 | A5C_A0388_Vcho_153817467
169634335 | YP_001708071 | ABSDF2913_Abau_169634335
184156423 | YP_001844762 | ACICU_00103_Abau_184156423
158335874 | YP_001517048 | AM1_2731_Amar_158335874
158336844 | YP_001518018 | AM1_3712_Amar_158336844
300783556 | YP_003763847 | AMED_1633_Amed_300783556
167769817 | ZP_02441870 | ANACOL_01151_Acol_167769817
303238852 | ZP_07325383 | AceceDRAFT_0731_Acel_303238852
303240378 | ZP_07326896 | AceceDRAFT_2244_Acel_303240378
256377585 | YP_003101245 | Amir_3505_Amir_256377585
226314127 | YP_002774023 | BBR47_45420_Bbre_226314127
30022569 | NP_834200 | BC4488_Bcer_30022569
206563730 | YP_002234493 | BCAM1881_Bcen_206563730
225619532 | YP_002720789 | BHWA1_00589_Bhyo_225619532
301167374 | CBW26956 | BMS_2150_Bmar_301167374
295087466 | CBK68989 | BXY_40670_Bxyl_295087466
134288349 | YP_001110512 | Bcep1808_6822_Bvie_134288349
255010211 | ZP_05282337 | Bfra3_010100013815_Bfra_255010211
296125416 | YP_003632668 | Bmur_0365_Bmur_296125416
302383816 | YP_003819639 | Bresu_2709_Bsub_302383816
212646224 | NP_507592 | C08E8.4_Cele_212646224
257460202 | ZP_05625306 | CAMGR0001_0616_Cgra_257460202
257093308 | YP_003166949 | CAP2UW1_1710_CAcc_257093308
239627871 | ZP_04670902 | CBFG_01593_Cbac_239627871
157165319 | YP_001467147 | CCC13826_2022_Ccon_157165319
295094771 | CBK83862 | CCU_25310_Csp._295094771
283836396 | ZP_06356137 | CIT292_10857_Cyou_283836396
225020576 | ZP_03709768 | CORMATOL_00583_Cmat_225020576
110802054 | YP_697488 | CPR_0151_Cper_110802054
282897552 | ZP_06305552 | CRD_01664_Rbro_282897552
256392113 | YP_003113677 | Caci_2927_Caci_256392113
256393748 | YP_003115312 | Caci_4610_Caci_256393748
256395008 | YP_003116572 | Caci_5873_Caci_256395008
150018370 | YP_001310624 | Cbei_3546_Cbei_150018370
256419128 | YP_003119781 | Cpin_0074_Cpin_256419128
220905714 | YP_002481025 | Cyan7425_0270_Csp._220905714
307153746 | YP_003889130 | Cyan7822_3925_Csp._307153746
66812724 | XP_640541 | DDB_G0281625_Ddis_66812724
66810169 | XP_638808 | DDB_G0283925_Ddis_66810169
330798615 | XP_003287347 | DICPUDRAFT_22458_Dpur_330798615
330802814 | XP_003289408 | DICPUDRAFT_35661_Dpur_330802814
330843562 | XP_003293720 | DICPUDRAFT_42446_Dpur_330843562
330846708 | XP_003295151 | DICPUDRAFT_85573_Dpur_330846708
166032191 | ZP_02235020 | DORFOR_01894_Dfor_166032191
15806282 | NP_294987 | DR_1263_Drad_15806282
160901192 | YP_001566774 | Daci_5761_Daci_160901192
320334379 | YP_004171090 | Deima_1776_Dmar_320334379
325284428 | YP_004256968 | Deipr_2488_Dpro_325284428
149186578 | ZP_01864890 | ED21_31874_Esp._149186578
158079465 | YP_001504278 | EFP_gp169_BPphiEF24C_158079465
67472915 | XP_652245 | EHI_017590_Ehis_67472915
170684265 | YP_001745340 | EcSMS35_3361_Ecol_170684265
298707265 | CBJ25892 | Esi_0017_0056_Esil_298707265
298714411 | CBJ27468 | Esi_0071_0113_Esil_298714411
298711392 | CBJ32535 | Esi_0345_0025_Esil_298711392
32565136 | NP_498956 | F44E2.8_Cele_32565136
46111757 | XP_382936 | FG02760.1_Gzea_46111757
150026339 | YP_001297165 | FP2309_Fpsy_150026339
295103146 | CBL00690 | FPR_02440_Fpra_295103146
111221771 | YP_712565 | FRAAL2340_Faln_111221771
237744336 | ZP_04574817 | FSDG_00336_Fsp._237744336
261415758 | YP_003249441 | Fisuc_1361_Fsuc_261415758
146298513 | YP_001193104 | Fjoh_0750_Fjoh_146298513
288920206 | ZP_06414521 | FrEUN1fDRAFT_4219_Fsp._288920206
312200713 | YP_004020774 | FraEuI1c_6936_Fsp._312200713
237813318 | YP_002897769 | GBP346_A3087_Bpse_237813318
291459520 | ZP_06598910 | GCWU000341_01684_Osp._291459520
229828516 | ZP_04454585 | GCWU000342_00580_Ssat_229828516
119476904 | ZP_01617185 | GP2143_10137_Mgam_119476904
254482777 | ZP_05096014 | GPB2148_1261_Mgam_254482777
296414614 | XP_002836993 | GSTUM_00003347001_Tmel_296414614
296424705 | XP_002841887 | GSTUM_00011304001_Tmel_296424705
261410041 | YP_003246282 | GYMC10_6272_Psp._261410041
197117872 | YP_002138299 | Gbem_1485_Gbem_197117872
189425639 | YP_001952816 | Glov_2583_Glov_189425639
168698168 | ZP_02730445 | GobsU_010100001512_Gobs_168698168
168699662 | ZP_02731939 | GobsU_010100009074_Gobs_168699662
168700969 | ZP_02733246 | GobsU_010100015693_Gobs_168700969
168704676 | ZP_02736953 | GobsU_010100034385_Gobs_168704676
154278399 | XP_001540013 | HCAG_05480_Acap_154278399
83646809 | YP_435244 | HCH_04109_Hche_83646809
83647036 | YP_435471 | HCH_04340_Hche_83647036
83649602 | YP_438037 | HCH_06997_Hche_83649602
262281016 | ZP_06058799 | HMPREF0012_02967_Acal_262281016
258545510 | ZP_05705744 | HMPREF0198_1779_Chom_258545510
300774513 | ZP_07084376 | HMPREF0204_10236_Cgle_300774513
299141967 | ZP_07035101 | HMPREF0665_01551_Pori_299141967
315224011 | ZP_07865852 | HMPREF1977_0666_Coch_315224011
326335654 | ZP_08201841 | HMPREF9071_1307_Csp._326335654
325690155 | EGD32159 | HMPREF9382_1113_Ssan_325690155
325694076 | EGD35994 | HMPREF9383_1770_Ssan_325694076
319937960 | ZP_08012360 | HMPREF9488_03196_Csp._319937960
223985602 | ZP_03635653 | HOLDEFILI_02959_Hfil_223985602
311695670 | ADP98543 | HP15_2779_Madh_311695670
237752248 | ZP_04582728 | HWAG_01373_Hwin_237752248
159896886 | YP_001543133 | Haur_0354_Haur_159896886
15078868 | NP_149618 | IIV6gp151_IiV6_15078868
310778851 | YP_003967184 | Ilyop_1055_Ipol_310778851
89055288 | YP_510739 | Jann_2797_Jsp._89055288
163754439 | ZP_02161561 | KAOT1_16128_Kalg_163754439
311894452 | BAJ26860 | KSE_10250_Kset_311894452
311895942 | BAJ28350 | KSE_25370_Kset_311895942
284029681 | YP_003379612 | Kfla_1718_Kfla_284029681
48696395 | YP_024435 | KgORF4_BPK_48696395
119486659 | ZP_01620709 | L8106_12950_Lsp._119486659
170107053 | XP_001884737 | LACBIDRAFT_252516_Lbic_170107053
170117768 | XP_001890069 | LACBIDRAFT_316770_Lbic_170117768
170095960 | XP_001879200 | LACBIDRAFT_318005_Lbic_170095960
327409634 | YP_004347054 | LAU_0089_LV_327409634
217965001 | YP_002350679 | LMHCC_1724_Lmon_217965001
217965272 | YP_002350950 | LMHCC_1997_Lmon_217965272
72168255 | XP_793312 | LOC588539_Spur_72168255
154331017 | XP_001561948 | LbrM06_V2.0110_Lbra_154331017
146070759 | XP_001463095 | LINJ_06_0130_Linf_146070759
124010457 | ZP_01695096 | M23134_00353_Mmar_124010457
124004845 | ZP_01689688 | M23134_02260_Mmar_124004845
124004851 | ZP_01689694 | M23134_02266_Mmar_124004851
124009340 | ZP_01694019 | M23134_07250_Mmar_124009340
284504143 | YP_003406858 | MAR_ORF111_MV_284504143
254412559 | ZP_05026333 | MC7420_6514_Mcht_254412559
254413191 | ZP_05026962 | MC7420_678_Mcht_254413191
238062132 | ZP_04606841 | MCAG_03098_Msp._238062132
330502141 | YP_004379010 | MDS_1227_Pmen_330502141
164657874 | XP_001730063 | MGL_3049_Mglo_164657874
315054313 | XP_003176531 | MGYG_00619_Agyp_315054313
108762267 | YP_633480 | MXAN_5330_Mxan_108762267
240141986 | YP_002966496 | MexAM1_META2p0262_Mext_240141986
302868047 | YP_003836684 | Micau_3582_Maur_302868047
117924481 | YP_865098 | Mmc1_1181_Masp_117924481
124262828 | YP_001023298 | Mpe_B0288_Mpet_124262828
84489297 | YP_447529 | Msp_0486_Msta_84489297
119509756 | ZP_01628901 | N9414_00365_Nspu_119509756
290996214 | XP_002680677 | NAEGRDRAFT_31151_Ngru_290996214
290996009 | XP_002680575 | NAEGRDRAFT_31328_Ngru_290996009
290990814 | XP_002678031 | NAEGRDRAFT_36485_Ngru_290990814
290997341 | XP_002681240 | NAEGRDRAFT_46602_Ngru_290997341
326330475 | ZP_08196783 | NBCG_01909_Nbac_326330475
302884348 | XP_003041070 | NECHADRAFT_29138_Nhae_302884348
261381097 | ZP_05985670 | NEISUBOT_05210_Nsub_261381097
301059840 | ZP_07200732 | NPH_6632_Dpro_301059840
258651665 | YP_003200821 | Namu_1431_Nmul_258651665
297563442 | YP_003682416 | Ndas_4523_Ndas_297563442
254453984 | ZP_05067421 | OA238_4610_Oant_254453984
156564215 | YP_001429725 | ORF234_BP0305phi8-36_156564215
300866977 | ZP_07111648 | OSCI_3190004_Osp._300866977
309791192 | ZP_07685724 | OSCT_1675_Otri_309791192
145348536 | XP_001418703 | OSTLU_35648_Oluc_145348536
149908726 | ZP_01897387 | PE36_21039_Msp._149908726
70733106 | YP_262879 | PFL_5821_Pflu_70733106
149175186 | ZP_01853808 | PM8797T_20343_Pmar_149175186
149176205 | ZP_01854821 | PM8797T_29763_Pmar_149176205
212541268 | XP_002150789 | PMAA_059590_Pmar_212541268
308069201 | YP_003870806 | PPE_02438_Ppol_308069201
281209628 | EFA83796 | PPL_02864_Ppal_281209628
226326967 | ZP_03802485 | PROPEN_00827_Ppen_226326967
294673111 | YP_003573727 | PRU_0345_Prum_294673111
294673143 | YP_003573759 | PRU_0382_Prum_294673143
152987782 | YP_001348410 | PSPA7_3050_Paer_152987782
152985284 | YP_001350552 | PSPA7_5219_Paer_152985284
330874307 | EGH08456 | PSYMP_06728_Psyr_330874307
332285914 | YP_004417825 | PT7_2661_Psp._332285914
189204778 | XP_001938724 | PTRG_08392_Ptri_189204778
326434983 | EGD80553 | PTSG_01145_Ssp._326434983
304407843 | ZP_07389494 | PaecuDRAFT_4172_Pcur_304407843
255940726 | XP_002561132 | Pc16g08100_Pchr_255940726
93005719 | YP_580156 | Pcryo_0891_Pcry_93005719
325107565 | YP_004268633 | Plabr_0990_Pbra_325107565
296122446 | YP_003630224 | Plim_2199_Plim_296122446
294875527 | XP_002767363 | Pmar_PMAR024558_Pmar_294875527
148652988 | YP_001280081 | PsycPRwf_1182_Psp._148652988
71064897 | YP_263624 | Psyc_0321_Parc_71064897
71065404 | YP_264131 | Psyc_0844_Parc_71065404
311978014 | YP_003987134 | R617_APMV_311978014
94501287 | ZP_01307808 | RED65_02704_Bmar_94501287
291535823 | CBL08935 | ROI_18700_Rint_291535823
240146453 | ZP_04745054 | ROSINTL182_08410_Rint_240146453
240147581 | ZP_04746182 | ROSINTL182_09631_Rint_240147581
154503599 | ZP_02040659 | RUMGNA_01423_Rgna_154503599
268609453 | ZP_06143180 | RflaF_010100008155_Rfla_268609453
241589866 | YP_002979891 | Rpic12D_5003_Rpic_241589866
317056301 | YP_004104768 | Rumal_1634_Ralb_317056301
259416444 | ZP_05740364 | SCH4B_1850_Sisp_259416444
302674848 | XP_003027108 | SCHCODRAFT_258659_Scom_302674848
302674850 | XP_003027109 | SCHCODRAFT_258660_Scom_302674850
302693411 | XP_003036384 | SCHCODRAFT_36431_Scom_302693411
302783817 | XP_002973681 | SELMODRAFT_413953_Smoe_302783817
329936685 | ZP_08286392 | SGM_1884_Sgri_329936685
156053544 | XP_001592698 | SS1G_05618_Sscl_156053544
125718681 | YP_001035814 | SSA_1883_Ssan_125718681
291448123 | ZP_06587513 | SSGG_05341_Sros_291448123
302558106 | ZP_07310448 | SSRG_01621_Sgri_302558106
170078553 | YP_001735191 | SYNPCC7002_A1948_Syn_170078553
224477787 | YP_002635393 | Sca_2305_Scar_224477787
90020054 | YP_525881 | Sde_0405_Sdeg_90020054
284036735 | YP_003386665 | Slin_1821_Slin_284036735
239939813 | ZP_04691750 | SrosN15_010100002350_Sros_239939813
271963927 | YP_003338123 | Sros_2401_Sros_271963927
269121732 | YP_003309909 | Sterm_3136_Ster_269121732
17564644 | NP_503984 | T24A6.7_Cele_17564644
254787804 | YP_003075233 | TERTU_3943_Ttur_254787804
99081738 | YP_613892 | TM1040_1897_Rsp._99081738
242799239 | XP_002483337 | TSTA_012120_Tsti_242799239
118370894 | XP_001018647 | TTHERM_00289300_Tthe_118370894
118401008 | XP_001032825 | TTHERM_00486130_Tthe_118401008
118397133 | XP_001030901 | TTHERM_00998900_Tthe_118397133
123462122 | XP_001316875 | TVAG_227690_Tvag_123462122
72391614 | XP_846101 | Tb927.7.4780_Tbru_72391614
71654521 | XP_815878 | Tc00.1047053507521.60_Tcru_71654521
269124625 | YP_003297995 | Tcur_0355_Tcur_269124625
113476072 | YP_722133 | Tery_2448_Tery_113476072
220934941 | YP_002513840 | Tgr7_1771_Tsul_220934941
84392320 | ZP_00991747 | V12B01_14190_Vspl_84392320
330468357 | YP_004406100 | VAB18032_22000_Vmar_330468357
269960099 | ZP_06174476 | VME_08600_Vhar_269960099
28899861 | NP_799516 | VPA0006_Vpar_28899861
148975384 | ZP_01812308 | VSWAT3_18363_Vbac_148975384
171913880 | ZP_02929350 | VspiD_010100021915_Vspi_171913880
294664143 | ZP_06729532 | XAUC_02590_Xfus_294664143
300723771 | YP_003713078 | XNC1_2895_Xnem_300723771
82407990 | 2b3wA | _Ecol_82407990
308516893 | CBW46998 | _BP1_308516893
154487137 | ZP_02028544 | _Bado_154487137
33601359 | NP_888919 | _Bbro_33601359
33595978 | NP_883621 | _Bpar_33595978
221067792 | ZP_03543897 | _Ctes_221067792
160945657 | ZP_02092883 | _Fpra_160945657
160945914 | ZP_02093140 | _Fpra_160945914
238022350 | ZP_04602776 | _Kora_238022350
298249651 | ZP_06973455 | _Krac_298249651
298250178 | ZP_06973982 | _Krac_298250178
32471506 | NP_864499 | _Rbal_32471506
17232521 | NP_489069 | all5029_Ana_17232521
229129773 | ZP_04258740 | bcere0015_42140_Bcer_229129773
330822167 | YP_004350995 | bgla_2p0770_Bgla_330822167
330818849 | YP_004351066 | bgla_3p0420_Bgla_330818849
330814539 | YP_004362714 | bgla_4p0890_Bgla_330814539
228982721 | ZP_04142980 | bthur0002_58540_Bthu_228982721
308814565 | YP_003934839 | gp30.3_BPSP18_308814565
288561223 | YP_003424709 | mru_1967_Mrum_288561223
325680741 | ZP_08160279 | nadE_Ralb_325680741
60461911 | YP_209629 | pIL105p2_Llac_60461911
310722519 | YP_003969342 | phiAS5_ORF0053_BPphiAS5_310722519
162451636 | YP_001614003 | sce3364_Scel_162451636
22300007 | NP_683254 | tlr2465_Telo_22300007
300869472 | ZP_07114055 | ybiA_Osp._300869472
311112847 | YP_003984069 | ybiA_Rden_311112847
296876279 | ZP_06900331 | ybiA_Spar_296876279
325693558 | EGD35477 | ybiA_Ssan_325693558
104779561 | YP_606059 | PSEEN0279_Pent_104779561
104779562 | YP_606060 | PSEEN0280_Pent_104779562
10639263 | CAC11265 | Ta0118_Taci_10639263
107099046 | ZP_01362964 | PaerPA_01000055_Paer_107099046
108763108 | YP_634797 | MXAN_6680_Mxan_108763108
110638931 | YP_679140 | kptA_Chut_110638931
110639136 | YP_679345 | CHU_2753_Chut_110639136
110645302 | YP_667941 | NANV_gp93_Nabi_110645302
110800227 | YP_694609 | kptA_Cper_110800227
113473935 | YP_718198 | ORF258_Ssp._113473935
11499148 | NP_070382 | AF1553_Aful_11499148
115387213 | XP_001211112 | ATEG_01934_Ater_115387213
116192183 | XP_001221904 | CHGG_05809_Cglo_116192183
116252353 | YP_768191 | kptA_Rleg_116252353
116495334 | YP_807068 | LSEI_1867_Lcas_116495334
116748284 | YP_844971 | Sfum_0839_Sfum_116748284
116754706 | YP_843824 | Mthe_1409_Mthe_116754706
118362535 | XP_001014494 | TTHERM_00854280_Tthe_118362535
118430933 | NP_147045 | kptA_Aper_118430933
118591032 | ZP_01548432 | SIAM614_20266_Lagg_118591032
119193120 | XP_001247166 | CIMG_00937_Cimm_119193120
119477262 | ZP_01617498 | GP2143_03029_Mgam_119477262
119483244 | ZP_01618658 | L8106_04306_Lsp._119483244
119497805 | XP_001265660 | NFIA_033290_Nfis_119497805
119498195 | XP_001265855 | NFIA_035260_Nfis_119498195
119871538 | YP_929545 | Pisl_0018_Pisl_119871538
120608868 | YP_968546 | Aave_0160_Acit_120608868
121719366 | XP_001276382 | ACLA_003690_Acla_121719366
124002565 | ZP_01687418 | M23134_05268_Mmar_124002565
124002814 | ZP_01687666 | M23134_04262_Mmar_124002814
124003655 | ZP_01688504 | M23134_03314_Mmar_124003655
124004042 | ZP_01688889 | M23134_05434_Mmar_124004042
124007251 | ZP_01691959 | M23134_04698_Mmar_124007251
124007793 | ZP_01692495 | M23134_01690_Mmar_124007793
124028223 | YP_001013543 | Hbut_1373_Hbut_124028223
125717421 | YP_001034554 | SSA_0561_Ssan_125717421
125718682 | YP_001035815 | SSA_1884_Ssan_125718682
126131670 | XP_001382360 | PICST_56016_Ssti_126131670
126460155 | YP_001056433 | Pcal_1549_Pcal_126460155
126465464 | YP_001040573 | Smar_0558_Smar_126465464
126652604 | ZP_01724768 | BB14905_19555_Bsp._126652604
126667035 | ZP_01738010 | MELB17_05794_Msp._126667035
126740444 | ZP_01756132 | RSK20926_16597_Rsp._126740444
13470984 | NP_102553 | msr0834_Mlot_13470984
13470985 | NP_102554 | msr0835_Mlot_13470985
145493555 | XP_001432773 | GSPATT00034855001_Ptet_145493555
145591275 | YP_001153277 | Pars_1047_Pars_145591275
145595385 | YP_001159682 | Strop_2864_Stro_145595385
145596643 | YP_001160940 | Strop_4133_Stro_145596643
145602059 | XP_001403403 | MGG_12911_Mory_145602059
146294612 | YP_001185036 | Sputcn32_3528_Sput_146294612
146298511 | YP_001193102 | Fjoh_0748_Fjoh_146298511
146305602 | YP_001186067 | Pmen_0565_Pmen_146305602
146341856 | YP_001206904 | BRADO4987_Brad_146341856
146417847 | XP_001484891 | PGUG_02620_Mgui_146417847
147919656 | YP_686600 | kptA_Umet_147919656
148256740 | YP_001241325 | BBta_5454_Brad_148256740
148654473 | YP_001274678 | RoseRS_0296_Rsp._148654473
148821249 | YP_001286003 | TBFG_10058_Mtub_148821249
148907021 | ABR16654 | _Psit_148907021
149173583 | ZP_01852213 | PM8797T_22603_Pmar_149173583
149175185 | ZP_01853807 | PM8797T_20338_Pmar_149175185
149186577 | ZP_01864889 | ED21_31869_Esp._149186577
149246000 | XP_001527470 | LELG_02299_Lelo_149246000
149919906 | ZP_01908381 | PPSIR1_29218_Ppac_149919906
149922143 | ZP_01910582 | PPSIR1_00892_Ppac_149922143
150018230 | YP_001310484 | Cbei_3402_Cbei_150018230
151945531 | EDN63772 | TPT1_Scer_151945531
153817479 | ZP_01970146 | A5C_A0387_Vcho_153817479
153872688 | ZP_02001506 | BGP_2335_Begg_153872688
153873366 | ZP_02001971 | BGP_1609_Begg_153873366
154253368 | YP_001414192 | Plav_2928_Plav_154253368
154295249 | XP_001548061 | BC1G_13438_Bfuc_154295249
154496777 | ZP_02035473 | BACCAP_01070_Pcap_154496777
154497918 | ZP_02036296 | BACCAP_01896_Pcap_154497918
15607201 | NP_214573 | _Mtub_15607201
156543836 | XP_001606670 | LOC100123064_Nvit_156543836
156740099 | YP_001430228 | Rcas_0073_Rcas_156740099
156845856 | XP_001645817 | Kpol_1054p4_Vpol_156845856
156937278 | YP_001435074 | Igni_0484_Ihos_156937278
157042782 | NP_001013309 | zgc:113138_Drer_157042782
157126123 | XP_001654547 | AaeL_AAEL010417_Aaeg_157126123
158333527 | YP_001514699 | AM1_0325_Amar_158333527
158335219 | YP_001516391 | AM1_2062_Amar_158335219
158337724 | YP_001518900 | AM1_4608_Amar_158337724
158521555 | YP_001529425 | Dole_1544_Dole_158521555
15891357 | NP_357029 | Atu3583_Atum_15891357
159037621 | YP_001536874 | Sare_2007_Sare_159037621
159038434 | YP_001537687 | Sare_2868_Sare_159038434
159038599 | YP_001537852 | Sare_3040_Sare_159038599
159901068 | YP_001547315 | Haur_4556_Haur_159901068
159901400 | YP_001547647 | Haur_4889_Haur_159901400
160939744 | ZP_02087091 | CLOBOL_04635_Cbol_160939744
16126106 | NP_420670 | CC_1863_Ccre_16126106
161528666 | YP_001582492 | Nmar_1158_Nmar_161528666
162450235 | YP_001612602 | kptA_Scel_162450235
162453007 | YP_001615374 | sce4731_Scel_162453007
162457230 | YP_001619597 | sce8945_Scel_162457230
162457272 | YP_001619639 | sce8987_Scel_162457272
163754443 | ZP_02161565 | KAOT1_16148_Kalg_163754443
163754444 | ZP_02161566 | KAOT1_16153_Kalg_163754444
163754445 | ZP_02161567 | KAOT1_16158_Kalg_163754445
163814521 | ZP_02205910 | COPEUT_00672_Ceut_163814521
163847525 | YP_001635569 | Caur_1965_Caur_163847525
163849264 | YP_001637308 | Caur_3741_Caur_163849264
167043400 | ABZ08102 | ALOHA_HF4000APKG1C9ctg2g5__167043400
167377905 | XP_001734581 | EDI_237770_Edis_167377905
167518371 | XP_001743526 | MONBRDRAFT_23195_Mbre_167518371
167588668 | ZP_02381056 | BuboB_010100025264_Bubo_167588668
167749542 | ZP_02421669 | EUBSIR_00500_Esir_167749542
167753772 | ZP_02425899 | _Aput_167753772
167757534 | ZP_02429661 | CLORAM_03084_Cram_167757534
167769835 | ZP_02441888 | ANACOL_01169_Acol_167769835
168049051 | XP_001776978 | PHYPADRAFT_194205_Ppat_168049051
168698114 | ZP_02730391 | GobsU_010100001232_Gobs_168698114
168699093 | ZP_02731370 | GobsU_010100006203_Gobs_168699093
168703011 | ZP_02735288 | GobsU_010100026009_Gobs_168703011
169773039 | XP_001820988 | AOR_1_740144_Aory_169773039
170105752 | XP_001884088 | LACBIDRAFT_153942_Lbic_170105752
170683612 | YP_001746786 | kptA_Ecol_170683612
170684105 | YP_001742169 | EcSMS35_0052_Ecol_170684105
170940179 | CAP65406 | _Pans_170940179
171913881 | ZP_02929351 | VspiD_010100021920_Vspi_171913881
171913882 | ZP_02929352 | VspiD_010100021925_Vspi_171913882
172064765 | YP_001812415 | BamMC406_6764_Bamb_172064765
182412866 | YP_001817932 | Oter_1044_Oter_182412866
182437433 | YP_001825152 | SGR_3640_Sgri_182437433
182438632 | YP_001826351 | SGR_4839_Sgri_182438632
18314222 | NP_560889 | PAE3647_Pyae_18314222
186681810 | YP_001865006 | Npun_R1352_Npun_186681810
189425258 | YP_001952435 | Glov_2199_Glov_189425258
189425638 | YP_001952815 | Glov_2582_Glov_189425638
19115427 | NP_594515 | SPAC2C4.12c_Spom_19115427
191169136 | ZP_03030895 | EcB7A_0638_Ecol_191169136
192290492 | YP_001991097 | Rpal_2100_Rpal_192290492
193070962 | ZP_03051891 | EcE110019_5086_Ecol_193070962
195016166 | XP_001984354 | Dgri\GH16409_Dgri_195016166
196229950 | ZP_03128814 | CfE428DRAFT_1979_Cfla_196229950
197246418 | AAI68833 | _X(Si_197246418
197286762 | YP_002152634 | PMI2933_Pmir_197286762
198415504 | XP_002120125 | LOC100186294_Cint_198415504
198425598 | XP_002120031 | LOC100175594_Cint_198425598
198471764 | XP_002133835 | Dpse\GA22571_Dpse_198471764
20093417 | NP_619492 | MA4638_Mace_20093417
20094870 | NP_614717 | KptA_Mkan_20094870
206563731 | YP_002234494 | BCAM1882_Bcen_206563731
206575484 | YP_002235807 | KPK_A0162_Kpne_206575484
206579710 | YP_002240751 | KPK_4974_Kpne_206579710
209527878 | ZP_03276367 | AmaxDRAFT_5193_Amax_209527878
209527890 | ZP_03276379 | AmaxDRAFT_5205_Amax_209527890
209544855 | YP_002277084 | Gdia_2732_Gdia_209544855
209921977 | YP_002296050 | ECSE_P1-0025_Ecol_209921977
210621794 | ZP_03292823 | CLOHIR_00768_Chir_210621794
21222199 | NP_627978 | _Scoe_21222199
21223327 | NP_629106 | _Scoe_21223327
213408531 | XP_002175036 | SJAG_03913_Sjap_213408531
213962768 | ZP_03391028 | CAPSP0001_0556_Cspu_213962768
213966822 | ZP_03394973 | kptA_Psyr_213966822
215486216 | YP_002328647 | E2348C_1093_Ecol_215486216
217979676 | YP_002363823 | Msil_3572_Msil_217979676
217979677 | YP_002363824 | Msil_3573_Msil_217979677
218295754 | ZP_03496550 | TaqDRAFT_4249_Taqu_218295754
218547498 | YP_002381289 | EFER_0059_Efer_218547498
218679791 | ZP_03527688 | RetlC8_010100013251_Retl_218679791
218779300 | YP_002430618 | Dalk_1450_Dalk_218779300
218780694 | YP_002432012 | Dalk_2854_Dalk_218780694
219121541 | XP_002181123 | PHATRDRAFT_21228_Ptri_219121541
221067794 | ZP_03543899 | _Ctes_221067794
221487185 | EEE25431 | TGGT1_013520_Tgon_221487185
222529646 | YP_002573528 | Athe_1661_Cbes_222529646
223935744 | ZP_03627660 | Cflav_PD6472_Ppar_223935744
223939130 | ZP_03631013 | Cflav_PD1558_Ppar_223939130
224002288 | XP_002290816 | THAPSDRAFT_22854_Tpse_224002288
224477788 | YP_002635394 | Sca_2306_Scar_224477788
224542154 | ZP_03682693 | CATMIT_01329_Cmit_224542154
225023628 | ZP_03712820 | EIKCOROL_00488_Ecor_225023628
225075180 | ZP_03718379 | NEIFLAOT_00180_Nfla_225075180
225181269 | ZP_03734714 | DealDRAFT_2303_Dalk_225181269
225388916 | ZP_03758640 | CLOSTASPAR_02657_Casp_225388916
225390142 | ZP_03759866 | CLOSTASPAR_03892_Casp_225390142
225559493 | EEH07776 | HCBG_04655_Acap_225559493
225620034 | YP_002721291 | BHWA1_01104_Bhyo_225620034
225620246 | YP_002721503 | BHWA1_01320_Bhyo_225620246
225682414 | EEH20698 | PABG_02929_Pbra_225682414
225684169 | EEH22453 | PABG_04664_Pbra_225684169
225707394 | ACO09543 | KPTA_Omor_225707394
226293790 | EEH49210 | PADG_05289_Pbra_226293790
226313333 | YP_002773227 | BBR47_37460_Bbre_226313333
226327538 | ZP_03803056 | PROPEN_01409_Ppen_226327538
226330224 | ZP_03805742 | _Ppen_226330224
226355053 | YP_002784793 | Deide_02300_Ddes_226355053
226471272 | CAX70717 | _Sjap_226471272
227508115 | ZP_03938164 | HMPREF0496_0278_Lbre_227508115
227893699 | ZP_04011504 | HMPREF0548_1222_Lult_227893699
228473982 | ZP_04058723 | CAPGI0001_2523_Cgin_228473982
228911570 | ZP_04075359 | bthur0013_57000_Bthu_228911570
228923828 | ZP_04087106 | bthur0011_48030_Bthu_228923828
228983067 | ZP_04143326 | bthur0002_62010_Bthu_228983067
229129771 | ZP_04258738 | bcere0015_42120_Bcer_229129771
229175166 | ZP_04302682 | bcere0006_42470_Bcer_229175166
237654251 | YP_002890565 | Tmz1t_3595_Tsp._237654251
237742025 | ZP_04572506 | FSCG_00598_Fsp._237742025
237800583 | ZP_04589044 | POR16_17293_Psyr_237800583
237813317 | YP_002897768 | GBP346_A3086_Bpse_237813317
238020853 | ZP_04601279 | _Kora_238020853
238061717 | ZP_04606426 | MCAG_02683_Msp._238061717
238061986 | ZP_04606695 | MCAG_02952_Msp._238061986
238490968 | XP_002376721 | AFLA_108510_Afla_238490968
238496189 | XP_002379330 | AFLA_133160_Afla_238496189
238550149 | NP_001153861 | TRPT1_Hsap_238550149
238916184 | YP_002929701 | EUBELI_00218_Eeli_238916184
238921299 | YP_002934814 | NT01EI_3442_Eict_238921299
239606461 | EEQ83448 | BDCG_00253_Ader_239606461
239626468 | ZP_04669499 | CBFG_00190_Cbac_239626468
239626503 | ZP_04669534 | CBFG_00225_Cbac_239626503
239627870 | ZP_04670901 | CBFG_01592_Cbac_239627870
239815282 | YP_002944192 | Vapar_2298_Vpar_239815282
239908249 | YP_002954990 | DMR_36130_Dmag_239908249
239987775 | ZP_04708439 | SrosN1_010100010753_Sros_239987775
239992555 | ZP_04713219 | SrosN1_010100035003_Sros_239992555
240272965 | EER36489 | HCDG_09373_Acap_240272965
241952517 | XP_002418980 | CD36_80320_Cdub_241952517
242218580 | XP_002475079 | POSPLDRAFT_41997_Ppla_242218580
242785264 | XP_002480559 | TSTA_033670_Tsti_242785264
251788569 | YP_003003290 | Dd1591_0935_Dzea_251788569
251794334 | YP_003009065 | Pjdr2_0298_Psp._251794334
253687260 | YP_003016450 | PC1_0863_Pcar_253687260
254169141 | ZP_04875977 | ABOONEI_1429_Aboo_254169141
254245305 | ZP_04938626 | BCPG_00001_Bcen_254245305
254302431 | ZP_04969789 | FNP_0054_Fnuc_254302431
254383863 | ZP_04999210 | SSAG_03610_Ssp._254383863
254387007 | ZP_05002286 | SSAG_06599_Ssp._254387007
254392683 | ZP_05007857 | SSCG_05109_Scla_254392683
254410814 | ZP_05024592 | MC7420_292_Mcht_254410814
254573246 | XP_002493732 | PAS_chr4_0312_Kpas_254573246
254578506 | XP_002495239 | ZYRO0B06600g_Zrou_254578506
255010210 | ZP_05282336 | Bfra3_010100013810_Bfra_255010210
255086119 | XP_002509026 | MICPUN_76559_Msp._255086119
255103268 | ZP_05332245 | CdifQCD-6_020200020820_Cdif_255103268
255638634 | ACU19622 | _Gmax_255638634
255712699 | XP_002552632 | KLTH0C09460g_Lthe_255712699
255930929 | XP_002557021 | Pc12g01220_Pchr_255930929
256006093 | ZP_05431024 | ClothDRAFT_2885_Cthe_256006093
256023435 | ZP_05437300 | E4_010100008678_Esp._256023435
256367844 | YP_003108401 | pEK499_p136_Ecol_256367844
256374811 | YP_003098471 | Amir_0662_Amir_256374811
256376037 | YP_003099697 | Amir_1903_Amir_256376037
256376409 | YP_003100069 | Amir_2283_Amir_256376409
256379719 | YP_003103379 | Amir_5718_Amir_256379719
256394652 | YP_003116216 | Caci_5516_Caci_256394652
256395290 | YP_003116854 | Caci_6159_Caci_256395290
256419129 | YP_003119782 | Cpin_0075_Cpin_256419129
256420608 | YP_003121261 | Cpin_1564_Cpin_256420608
256422007 | YP_003122660 | Cpin_2983_Cpin_256422007
257063188 | YP_003142860 | Shel_04510_Shel_257063188
257093309 | YP_003166950 | CAP2UW1_1711_CAcc_257093309
257095819 | YP_003169460 | CAP2UW1_4295_CAcc_257095819
257125945 | YP_003164059 | Lebu_1175_Lbuc_257125945
257455836 | ZP_05621061 | ENHAE0001_1187_Eaer_257455836
258545015 | ZP_05705249 | kptA_Chom_258545015
258545511 | ZP_05705745 | HMPREF0198_1780_Chom_258545511
258574383 | XP_002541373 | UREG_00888_Uree_258574383
260554979 | ZP_05827200 | HMPREF0010_00583_Abau_260554979
260557664 | ZP_05829878 | HMPREF0010_03261_Abau_260557664
260590817 | ZP_05856275 | HMPREF0973_00239_Pver_260590817
260781042 | XP_002585636 | BRAFLDRAFT_274539_Bflo_260781042
260782199 | XP_002586178 | BRAFLDRAFT_132446_Bflo_260782199
260802161 | XP_002595961 | BRAFLDRAFT_128074_Bflo_260802161
260889106 | ZP_05900369 | GCWU000323_00265_Lhof_260889106
260889576 | ZP_05900839 | GCWU000323_00737_Lhof_260889576
260945038 | XP_002616817 | CLUG_04058_Clus_260945038
261334507 | CBH17501 | TbgDal_XI6190_Tbru_261334507
261344446 | ZP_05972090 | PROVRUST_05684_Prus_261344446
262039223 | ZP_06012541 | HMPREF0554_2331_Lgoo_262039223
262067268 | ZP_06026880 | FUSPEROL_01544_Fper_262067268
262195534 | YP_003266743 | Hoch_2307_Hoch_262195534
262199521 | YP_003270730 | Hoch_6367_Hoch_262199521
262383473 | ZP_06076609 | HMPREF0103_2522_Bact_262383473
268609383 | ZP_06143110 | RflaF_010100007781_Rfla_268609383
268610712 | ZP_06144439 | RflaF_010100014602_Rfla_268610712
269118724 | YP_003306901 | Sterm_0085_Ster_269118724
269121733 | YP_003309910 | Sterm_3137_Ster_269121733
269140414 | YP_003297115 | ETAE_3071_Etar_269140414
269140415 | YP_003297116 | ETAE_3072_Etar_269140415
270293299 | ZP_06199508 | HMPREF0850_01400_Ssp._270293299
271967482 | YP_003341678 | Sros_6206_Sros_271967482
281203630 | EFA77827 | PPL_09325_Ppal_281203630
281203700 | EFA77897 | PPL_09397_Ppal_281203700
281416943 | ZP_06247963 | _Cthe_281416943
282864000 | ZP_06273057 | SACTEDRAFT_3602_Ssp._282864000
282881570 | ZP_06290239 | HMPREF9019_0398_Ptim_282881570
283783211 | YP_003373965 | HMPREF0424_0738_Gvag_283783211
284033571 | YP_003383502 | Kfla_5697_Kfla_284033571
284038124 | YP_003388054 | Slin_3244_Slin_284038124
284038905 | YP_003388835 | Slin_4048_Slin_284038905
284119730 | ZP_06386788 | POR_1392_CPor_284119730
284163819 | YP_003402098 | Htur_0527_Htur_284163819
284988800 | YP_003407354 | Gobs_0177_Gobs_284988800
28575019 | NP_788477 | CG33057_Dmel_28575019
288457846 | YP_003422714 | ZZM4_0145_Zmob_288457846
288931212 | YP_003435272 | Ferp_0829_Fpla_288931212
288932585 | YP_003436645 | Ferp_2246_Fpla_288932585
288940281 | YP_003442521 | Alvin_0536_Avin_288940281
289663132 | ZP_06484713 | XcampvN_010100008602_Xcam_289663132
289770606 | ZP_06529984 | SSPG_03874_Sliv_289770606
290960596 | YP_003491778 | SCAB_62181_Ssca_290960596
290961991 | YP_003493173 | SCAB_76641_Ssca_290961991
290963088 | YP_003494270 | SCAB_88101_Ssca_290963088
290974534 | XP_002670000 | NAEGRDRAFT_59792_Ngru_290974534
290974944 | XP_002670204 | NAEGRDRAFT_74830_Ngru_290974944
290988948 | XP_002677132 | NAEGRDRAFT_49152_Ngru_290988948
291231763 | XP_002735833 | LOC100372879_Skow_291231763
291237935 | XP_002738885 | LOC100367844_Skow_291237935
291288929 | YP_003517432 | pKF94_017_Kpne_291288929
291300690 | YP_003511968 | Snas_3205_Snas_291300690
291301515 | YP_003512793 | Snas_4048_Snas_291301515
291438820 | ZP_06578210 | SSFG_03915_Sgha_291438820
291444753 | ZP_06584143 | SSGG_01970_Sros_291444753
291453417 | ZP_06592807 | SSHG_03710_Salb_291453417
292493384 | YP_003528823 | Nhal_3405_Nhal_292493384
294494713 | YP_003541206 | Mmah_0023_Mmah_294494713
294628199 | ZP_06706759 | SSTG_00199_Ssp._294628199
294657248 | XP_459547 | DEHA2E05236g_Dhan_294657248
294664142 | ZP_06729531 | XAUC_02580_Xfus_294664142
294669065 | ZP_06734151 | NEIELOOT_00979_Nelo_294669065
294781860 | ZP_06747192 | HMPREF0400_02088_Fsp._294781860
294817221 | ZP_06775863 | SCLAV_p0684_Scla_294817221
295087467 | CBK68990 | BXY_40680_Bxyl_295087467
295093305 | CBK82396 | CCU_05780_Csp._295093305
295658070 | XP_002789598 | PAAG_08523_Pbra_295658070
295839520 | ZP_06826453 | SSBG_06269_Ssp._295839520
296114887 | ZP_06833535 | GXY_03898_Ghan_296114887
296121824 | YP_003629602 | Plim_1570_Plim_296121824
296130288 | YP_003637538 | Cfla_2451_Cfla_296130288
296130683 | YP_003637933 | Cfla_2850_Cfla_296130683
296416279 | XP_002837808 | GSTUM_00005659001_Tmel_296416279
296446434 | ZP_06888378 | MettrDRAFT_2094_Mtri_296446434
296821722 | XP_002850170 | MCYG_00274_Aota_296821722
296825168 | XP_002850772 | MCYG_00876_Aota_296825168
297162424 | ADI12136 | SBI_09018_Sbin_297162424
297192271 | ZP_06909669 | SSDG_01873_Spri_297192271
297194315 | ZP_06911713 | SSDG_06844_Spri_297194315
297202026 | ZP_06919423 | SSEG_09591_Ssvi_297202026
297202028 | ZP_06919425 | SSEG_04858_Ssvi_297202028
297204161 | ZP_06921558 | SSEG_04772_Ssvi_297204161
297267544 | XP_001115358 | LOC717911_Mmul_297267544
297561069 | YP_003680043 | Ndas_2112_Ndas_297561069
297561422 | YP_003680396 | Ndas_2470_Ndas_297561422
297564265 | YP_003683238 | Ndas_5352_Ndas_297564265
297618118 | YP_003703277 | Slip_1960_Slip_297618118
298245737 | ZP_06969543 | _Krac_298245737
298246337 | ZP_06970143 | _Krac_298246337
298248426 | ZP_06972231 | _Krac_298248426
298250918 | ZP_06974722 | _Krac_298250918
29826642 | NP_821276 | SAV_102_Save_29826642
29829850 | NP_824484 | SAV_3308_Save_29829850
29830778 | NP_825412 | SAV_4235_Save_29830778
298711928 | CBJ48615 | Esi_0039_0083_Esil_298711928
299141966 | ZP_07035100 | HMPREF0665_01550_Pori_299141966
299472429 | CBN77617 | Esi_0004_0276_Esil_299472429
299472531 | CBN77316 | Esi_0044_0118_Esil_299472531
30022567 | NP_834198 | BC4486_Bcer_30022567
300774500 | ZP_07084363 | kptA_Cgle_300774500
300774505 | ZP_07084368 | HMPREF0204_10228_Cgle_300774505
300774507 | ZP_07084370 | HMPREF0204_10230_Cgle_300774507
300784169 | YP_003764460 | kptA_Amed_300784169
300789763 | YP_003770054 | AMED_7947_Amed_300789763
300854685 | YP_003779669 | CLJU_c15030_Clju_300854685
300867123 | ZP_07111789 | OSCI_3240019_Osp._300867123
300868768 | ZP_07113379 | OSCI_3800101_Osp._300868768
300868996 | ZP_07113599 | kptA_Osp._300868996
300869632 | ZP_07114212 | OSCI_4130042_Osp._300869632
301058276 | ZP_07199316 | NPH_6498_Dpro_301058276
302344076 | YP_003808605 | Deba_2657_Dbaa_302344076
302411952 | XP_003003809 | VDBG_06251_Valb_302411952
30249340 | NP_841410 | NE1363_Neur_30249340
302504024 | XP_003013971 | ARB_07691_Aben_302504024
302525419 | ZP_07277761 | SSMG_01801_Ssp._302525419
302526847 | ZP_07279189 | SSMG_03229_Ssp._302526847
302529076 | ZP_07281418 | SSMG_05458_Ssp._302529076
302535927 | ZP_07288269 | SSNG_03890_Ssp._302535927
302548144 | ZP_07300486 | SSOG_08569_Shim_302548144
302549980 | ZP_07302322 | SSQG_01209_Svir_302549980
302553253 | ZP_07305595 | SSQG_04482_Svir_302553253
302657470 | XP_003020456 | TRV_05457_Tver_302657470
302686072 | XP_003032716 | SCHCODRAFT_40957_Scom_302686072
302756333 | XP_002961590 | SELMODRAFT_35951_Smoe_302756333
302757341 | XP_002962094 | SELMODRAFT_77175_Smoe_302757341
302766619 | XP_002966730 | SELMODRAFT_85925_Smoe_302766619
302782377 | XP_002972962 | SELMODRAFT_98231_Smoe_302782377
302796097 | XP_002979811 | SELMODRAFT_111206_Smoe_302796097
302851356 | XP_002957202 | VOLCADRAFT_119630_Vcar_302851356
302864537 | YP_003833174 | Micau_0029_Maur_302864537
302866493 | YP_003835130 | Micau_2007_Maur_302866493
302867267 | YP_003835904 | Micau_2794_Maur_302867267
302868056 | YP_003836693 | Micau_3591_Maur_302868056
302869104 | YP_003837741 | Micau_4654_Maur_302869104
302916847 | XP_003052234 | NECHADRAFT_79207_Nhae_302916847
302922871 | XP_003053556 | NECHADRAFT_74824_Nhae_302922871
303240380 | ZP_07326898 | AceceDRAFT_2246_Acel_303240380
303240837 | ZP_07327349 | AceceDRAFT_2697_Acel_303240837
303241812 | ZP_07328308 | AceceDRAFT_3656_Acel_303241812
303284891 | XP_003061736 | MICPUCDRAFT_48280_Mpus_303284891
303312351 | XP_003066187 | CPC735_054120_Cpos_303312351
304309800 | YP_003809398 | HDN1F_01480_Gpro_304309800
304405428 | ZP_07387087 | PaecuDRAFT_1748_Pcur_304405428
304560215 | ADM42879 | ETAF_2777_Etar_304560215
305663054 | YP_003859342 | Igag_0628_Iagg_305663054
307104106 | EFN52361 | CHLNCDRAFT_138778_Cvar_307104106
307105263 | EFN53513 | CHLNCDRAFT_59736_Cvar_307105263
307150228 | YP_003885612 | Cyan7822_0291_Csp._307150228
307154521 | YP_003889905 | Cyan7822_4726_Csp._307154521
307299774 | ZP_07579566 | ThebaDRAFT_2537_Tbac_307299774
307595891 | YP_003902208 | Vdis_1783_Vdis_307595891
307823107 | ZP_07653337 | MettuDRAFT_1182_Mtun_307823107
307823108 | ZP_07653338 | MettuDRAFT_1183_Mtun_307823108
307946056 | ZP_07661391 | TRICHSKD4_4759_Rsp._307946056
308270161 | CBX26773 | N47_A08020_UDes_308270161
308446799 | XP_003087265 | CRE_02794_Crem_308446799
309811906 | ZP_07705678 | HMPREF0321_1867_Dsp._309811906
310641074 | YP_003945832 | PPSC2_c1614_Ppol_310641074
310778852 | YP_003967185 | Ilyop_1056_Ipol_310778852
310792989 | EFQ28450 | GLRG_03594_Ggra_310792989
310796940 | EFQ32401 | GLRG_07671_Ggra_310796940
310818319 | YP_003950677 | STAUR_1046_Saur_310818319
310818708 | YP_003951066 | STAUR_1435_Saur_310818708
310831101 | YP_003969744 | crov112_CrVB_310831101
311896751 | BAJ29159 | KSE_33500_Kset_311896751
311899069 | BAJ31477 | kptA_Kset_311899069
311900362 | BAJ32770 | KSE_70120_Kset_311900362
312142649 | YP_003994095 | Halsa_0262_Hhyd_312142649
312199543 | YP_004019604 | FraEuI1c_5750_Fsp._312199543
312220715 | CBY00656 | LEMA_P017860.1_Lmac_312220715
312886331 | ZP_07745943 | MucpaDRAFT_5912_Mpal_312886331
312888255 | ZP_07747832 | MucpaDRAFT_5105_Mpal_312888255
312888451 | ZP_07748025 | MucpaDRAFT_5539_Mpal_312888451
313682815 | YP_004060553 | Sulku_1692_Skuj_313682815
315054759 | XP_003176754 | MGYG_00842_Agyp_315054759
315230724 | YP_004071160 | TERMP_00961_Tbar_315230724
315502903 | YP_004081790 | ML5_2113_Msp._315502903
315504426 | YP_004083313 | ML5_3650_Msp._315504426
315506327 | YP_004085214 | ML5_5602_Msp._315506327
315652379 | ZP_07905368 | HMPREF0381_2362_Esab_315652379
317056274 | YP_004104741 | Rumal_1607_Ralb_317056274
317126949 | YP_004093231 | Bcell_0212_Bcel_317126949
318058555 | ZP_07977278 | SSA3_010100011465_Ssp._318058555
319936601 | ZP_08011014 | HMPREF9488_01847_Csp._319936601
320010749 | ADW05599 | Sfla_4190_Sfla_320010749
320095331 | ZP_08027020 | HMPREF9005_1632_Asp._320095331
320168635 | EFW45534 | CAOG_03518_Cowc_320168635
320333489 | YP_004170200 | Deima_0881_Dmar_320333489
320333790 | YP_004170501 | Deima_1184_Dmar_320333790
322505025 | CAM42259 | LBRM_24_0830_Lbra_322505025
322699163 | EFY90927 | MAC_03043_Macr_322699163
322707126 | EFY98705 | MAA_05844_Mani_322707126
322708785 | EFZ00362 | MAA_04139_Mani_322708785
322802863 | EFZ23054 | SINV_01220_Sinv_322802863
322815443 | EFZ24097 | TCSYLVIO_9776_Tcru_322815443
322832748 | YP_004212775 | Rahaq_2033_Rsp._322832748
323140426 | ZP_08075355 | HMPREF9443_00109_Psuc_323140426
32476856 | NP_869850 | _Rbal_32476856
325108247 | YP_004269315 | Plabr_1682_Pbra_325108247
325189229 | CCA23752 | AlNc14C205G8800_Alai_325189229
325283812 | YP_004256353 | Deipr_1598_Dpro_325283812
325690156 | EGD32160 | HMPREF9382_1114_Ssan_325690156
325917965 | ZP_08180134 | XVE_4155_Xves_325917965
325928686 | ZP_08189859 | XPE_3947_Xper_325928686
326431934 | EGD77504 | PTSG_08602_Ssp._326431934
326470706 | EGD94715 | TESG_02225_Tton_326470706
326779281 | ZP_08238546 | SACT1_5140_Sgri_326779281
326943719 | AEA19612 | CT43_P281274_Bthu_326943719
327286590 | XP_003228013 | LOC100564547_Acar_327286590
327308048 | XP_003238715 | TERG_00702_Trub_327308048
327352957 | EGE81814 | BDDG_04757_Ader_327352957
327400244 | YP_004341083 | Arcve_0335_Aven_327400244
328769603 | EGF79646 | BATDEDRAFT_4585_Bden_328769603
328862875 | EGG11975 | MELLADRAFT_101818_Mlar_328862875
328866607 | EGG14990 | DFA_09810_Dfas_328866607
328867666 | EGG16048 | DFA_09720_Dfas_328867666
328871094 | EGG19465 | DFA_00042_Dfas_328871094
328884339 | CCA57578 | SVEN_4292_Sven_328884339
328886920 | CCA60159 | SVEN_6873_Sven_328886920
328952864 | YP_004370198 | Desac_1154_Dace_328952864
328958126 | YP_004375512 | CAR_c18390_Csp._328958126
329184512 | AEB80270 | Dalk_0002_AVC_Dalk_329184512
329847506 | ZP_08262534 | ABI_05710_Abip_329847506
329935140 | ZP_08285131 | SGM_6648_Sgri_329935140
329935335 | ZP_08285301 | SGM_6818_Sgri_329935335
329996741 | ZP_08302538 | HMPREF9538_00174_Ksp._329996741
330467180 | YP_004404923 | VAB18032_16085_Vmar_330467180
330469061 | YP_004406804 | VAB18032_25530_Vmar_330469061
330469448 | YP_004407191 | VAB18032_27591_Vmar_330469448
330508961 | YP_004385389 | MCON_3311_Mcon_330508961
330795375 | XP_003285749 | DICPUDRAFT_46322_Dpur_330795375
330801102 | XP_003288569 | DICPUDRAFT_34288_Dpur_330801102
330977809 | EGH77712 | PSYAP_13685_Psyr_330977809
330983843 | EGH81946 | PLA107_02335_Psyr_330983843
331216956 | XP_003321157 | PGTG_02199_Pgra_331216956
332361966 | EGJ39768 | kptA_Ssan_332361966
332668288 | YP_004451076 | Halhy_6384_Hhyd_332668288
332671633 | YP_004454641 | Celf_3140_Cfim_332671633
333027909 | ZP_08455973 | STTU_5412_Ssp._333027909
333374005 | ZP_08465898 | HMPREF9374_3644_Dsp._333374005
333378220 | ZP_08469951 | HMPREF9456_01546_Dmos_333378220
333381571 | ZP_08473251 | HMPREF9455_01417_Dgad_333381571
333912499 | YP_004486231 | DelCs14_0840_Dsp._333912499
333985238 | YP_004514448 | Metme_3585_Mmet_333985238
334120906 | ZP_08494983 | MicvaDRAFT_0510_Mvag_334120906
334135982 | ZP_08509461 | HMPREF9413_4358_Psp._334135982
336117044 | YP_004571811 | MLP_13940_Mpho_336117044
336250841 | YP_004594551 | EAE_21855_Eaer_336250841
336366767 | EGN95113 | SERLA73DRAFT_143184_Slac_336366767
336428119 | ZP_08608104 | HMPREF0994_04110_Lbac_336428119
336471510 | EGO59671 | NEUTE1DRAFT_109155_Ntet_336471510
336475983 | YP_004615124 | Mzhil_0024_Mzhi_336475983
338211687 | YP_004655740 | Runsl_2196_Rsli_338211687
338532263 | YP_004665597 | LILAB_13060_Mful_338532263
338811714 | ZP_08623919 | ALO_06468_Alon_338811714
339009751 | ZP_08642322 | BRLA_c35710_Blat_339009751
340377247 | XP_003387141 | LOC100640582_Aque_340377247
340521231 | EGR51466 | TRIREDRAFT_75394_Tree_340521231
340754465 | ZP_08691218 | FSAG_02029_Fsp._340754465
342875667 | EGU77385 | FOXB_12108_Foxy_342875667
34497880 | NP_902095 | CV_2425_Cvio_34497880
344999740 | YP_004802594 | SACTE_2158_Ssp._344999740
345013407 | YP_004815761 | Strvi_5976_Svio_345013407
345368115 | EGX00122 | ECSTECMHI813_4950_Ecol_345368115
346318305 | EGX87909 | CCM_09532_Cmil_346318305
38505777 | NP_942396 | sll8002_Ssp_38505777
45198857 | NP_985886 | AGOS_AFR339W_Agos_45198857
46309426 | YP_006316 | ORF28_AsGV_46309426
49477941 | YP_037101 | kptA_Bthu_49477941
50290283 | XP_447573 | CAGL0I07469g_Cgla_50290283
50305581 | XP_452751 | KLLA0C12397g_Klac_50305581
50547707 | XP_501323 | YALI0C01287g_Ylip_50547707
53718401 | YP_107387 | BPSL0762_Bpse_53718401
55379941 | YP_137791 | kptA_Hmar_55379941
58383293 | YP_194865 | pU302L_059_Sent_58383293
60461910 | YP_209628 | pIL105p1_Llac_60461910
66358336 | XP_626346 | cgd2_1210_Cpar_66358336
66802638 | XP_635191 | DDB_G0291408_Ddis_66802638
66807493 | XP_637469 | DDB_G0286929_Ddis_66807493
66813652 | XP_641005 | DDB_G0280835_Ddis_66813652
67921554 | ZP_00515072 | CwatDRAFT_5127_Cwat_67921554
70733133 | YP_262906 | PFL_5848_Pflu_70733133
70988759 | XP_749234 | AFUA_2G00980_Afum_70988759
71064898 | YP_263625 | Psyc_0322_Parc_71064898
72006229 | XP_780840 | LOC575340_Spur_72006229
72010085 | XP_786744 | LOC581663_Spur_72010085
74317508 | YP_315248 | Tbd_1490_Tden_74317508
78223734 | YP_385481 | Gmet_2535_Gmet_78223734
83643039 | YP_431474 | HCH_00129_Hche_83643039
83647694 | YP_436129 | HCH_05019_Hche_83647694
83649603 | YP_438038 | HCH_06998_Hche_83649603
84392321 | ZP_00991748 | V12B01_14195_Vspl_84392321
84499284 | ZP_00997572 | OB2597_05135_Obat_84499284
84499293 | ZP_00997581 | OB2597_05180_Obat_84499293
84501233 | ZP_00999438 | OB2597_12748_Obat_84501233
85068247 | XP_962139 | NCU07285_Ncra_85068247
85109317 | XP_962858 | NCU06254_Ncra_85109317
87310926 | ZP_01093052 | DSM3645_18471_Bmar_87310926
87311897 | ZP_01094009 | DSM3645_04855_Bmar_87311897
88856595 | ZP_01131252 | A20C1_02579_Mact_88856595
90419305 | ZP_01227215 | SI859A1_01336_Aman_90419305
91080221 | XP_972212 | LOC660925_Tcas_91080221
91203343 | CAJ72982 | kustd2237_CKue_91203343
91215317 | ZP_01252289 | P700755_13507_Ptor_91215317
94971452 | YP_593500 | Acid345_4426_CKor_94971452

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