SUPPLEMENTARY MATERIAL
Identification of components of novel NAD-dependent metabolic systems and prediction of their biochemical functions



Robson F. de Souza and L. Aravind*,

* Address for correspondence: L. Aravind (aravind@mail.nih.gov)

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA



ABSTRACT
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous cofactor participating in numerous redox reactions. It is also an important substrate for regulatory modifications of proteins and nucleic acids via the addition ADP-ribose moieties or removal of acyl groups by transfer to ADP-ribose. In this study, we use in-depth sequence, structure and genomic context analysis to uncover new enzymes and substrate-binding proteins in NAD-utilizing metabolic and macromolecular modification systems. We show that Escherichia coli YbiA and related families of domains from diverse bacteria, viruses and eukaryotes are previously unrecognized components of NAD-utilizing systems that probably operate on ADP ribose derivatives. Using contextual analysis we show that some of these proteins potentially act in the context of RNA repair, where NAD is used to remove 2'-3' cyclic phosphodiester linkages. Likewise, we show that another family of YbiA-related enzymes is likely to comprise a novel NAD-dependent ADP-ribosylation system for proteins, in conjunction with a previously unrecognized ADP-ribosyltransferase. A similar ADP-ribosyltransferase is also coupled with MACRO or ADP-ribosylglycohydrolase domain proteins in other related systems, suggesting that all these novel systems are likely to comprise pairs of ADP-ribosylation and ribosylglycohydrolase enzymes analogous to the DraG-DraT system that regulates the nitrogenase in nitrogen-fixing bacteria. We present evidence that some of these systems are likely to regulate certain restriction modification systems through ADP-ribosylation in bacteria. The ADP-ribosyltransferases found in this system also through light on the evolution of this fold and the origin of the eukaryotic polyADP-ribosyltransferases. We also identify a novel biosynthetic pathway that might be involved in the synthesis of a novel NMN/NAD-like compound in conjunction with an asparagine synthetase and AMPylating peptide ligase. We use the data derived from this analysis to understand the origin and early evolutionary trajectories of key NAD-utilizing enzymes and present targets for future biochemical investigations.

Contents
  • Phyletic distribution, domain architectures and gene neighborhoods of various NAD+ related genes
    • Multiple Sequence Alignment of the NADA family 
    #==== BC4488 family
ALIGN                                -    ---EEEE------------------------------------------------HHHHHHHHH-EE--E-------------------------HHHHH------------------------------------------EEEEE-------------HHHHHHHHHHHHH------------------------------HHHHHHHHH--------H-------------------HHHHH-----------------------------------HHHHHHHHHH---------
HMM                                  -    --EEEEEE-----------EEE-------------------------------EEEEEEEEEEEEEE--EE----------------------HHHHHHH------------------------------------------EEEEEE----------HHHHHHHHHHHHHHHH-----------------------------HHHHHHHH----------EEEEEE----------------HH-----------------------------------HHHHHHHHHH----HHHH-
FREQ                                 -    --EEEE-------------------------------------------------EEEEHHEEE--E--EE-----------------------HHHHHH-------HHHHHHH-----------------------------EEEEE------------HHHHHHHHHHHHHHH---------------------------HHHHHHHHHH--------HHH-----------------HHHHH-----------------------------------HHHHHHHHHHH---HHHH-
PSSM                                 -    -----E---------------------------------------------------EE--HE-------------------------------HHHHH---------------------------------------------EEE--------------HHHHHHHHHHHHHH---------------------------HHHHHHHHHH----------EEE-------------------H-----------------------------------HHHHHHHHH----------
FINAL                                -    --EEEEE-------------E---------------------------------EEEEEEEEEEEEE--EE----------------------HHHHHHH---------HHHH-----------------------------EEEEEE------------HHHHHHHHHHHHHH----------------------------HHHHHHHHHH----------EEEEE--------------HHHH-----------------------------------HHHHHHHHHH----HHHH-
                                                                #--                                  #      #  --                                         --                                                  -   -     -                          -                      #            -
ROSINTL182_09631_Rint_240147581      49   EKALEVSSKSE----VRVGKEIGAFS------LEL-DG------------------IFLENVFQAAK--QY-----------------ENGGPYLDLLNV-------SPKQAKRDERHCN-------------------SGKLVGFVRNDEI---WTLEPKTAFYDYIYISALIK--------------------------FNGYDLNISEY--------QWFTDIEFNP-------QKSINCQA-----------------------------------RAVAIYVALQKTALFNSLK  196  240147581  bacteria>firmicutes                            
ROI_18700_Rint_291535823             49   EKALEVSSKSE----VRVGKEIGAFS------LEL-DG------------------IFLENVFQAAK--QY-----------------ENGGPYLDLLNV-------SPKQAKRDERHCN-------------------SGKLVGFVRNDEI---WTLEPKTAFYDYIYISALIK--------------------------FNGYDLNISEY--------QWFTDIEFNP-------QKSINCQA-----------------------------------RAGSDWIGRW---------  185  291535823  bacteria>firmicutes                            
Sca_2305_Scar_224477787              53   DKLLEVSSKSE----KSIGVKASAFN----LKISTVKG----------------HHLSVEQIFQSSK--VY-----------------KKAGNQNYLLEEG-----YNSKEMKQKLREIDK------------------DDYMIKYSSFHQD---FPLEPKTLFYNWIYINALNQ--------------------------NEEVAKEILKY--------EAFTDIEFNP-------KRSFNCQA-----------------------------------EACAIYVSLVKQKNLDEAL  208  224477787  bacteria>firmicutes                            
pIL105p2_Llac_60461911               54   KKVLEISTKSP----TDLGVELSAFN----LKIQTKQ----------------EIYFTVESAFQSSK--VF-----------------ENGGPYDDLLLK-------GSREAKKDIRLKS-------------------SGKVIGFKYLNRE---FPSEPKTFFYNWLYVNALDK--------------------------NKKLSKELLSY--------DSFTDIEFNP-------EKSINCQA-----------------------------------EAAALYVSLSHKKLLTTAL  206  60461911   bacteria>firmicutes                            
HMPREF9383_1770_Ssan_325694076       58   LKVLEVSTASE----EEFGKECSAFN----LQLTLRNG----------------SKYSVESLFQSSK--VF----------------KNYGRVNQDLDL--------DAKAVKRQVRSIEV------------------NDKLIEFDFLGVK---FPLLPRTYFYNWLYVNALFQ--------------------------NTELSNFILQY--------DAFTDINFNP-------NKSINCQA-----------------------------------EACSIFLYLAKNSLLNDSI  211  325694076  bacteria>firmicutes                            
SSA_1883_Ssan_125718681              50   KKILEVSSKSI----DQVGRAASAFN----LKVTLKSG----------------KVYSVEQIFQGSK--VF----------------KKNGSQLKLLDSM-------TSKELKKIVGKLHQ------------------VDKLVEFESFGQH---FPLEPQTFFYNWLYINSLNQ--------------------------HKSLANQIIKY--------DAFTDIEFNP-------EKSKNCQA-----------------------------------EACSIYIFLYKSGLLDFAL  204  125718681  bacteria>firmicutes                            
HMPREF9382_1113_Ssan_325690155       58   LKVLEVSTASE----EEFGKECSAFN----LQLTLRNG----------------NKYSVESLFQSSK--VF----------------KNYGRVNQDLDL--------DAKAVKRQVRSIEV------------------NDKLIEFDFLGVK---FPLLPRTYFYNWLYVNALFQ--------------------------NTELSNFILQY--------DAFTDINFNP-------NKSINCQA-----------------------------------EACSIFLYLAKNSLLNDSI  211  325690155  bacteria>firmicutes                            
CBFG_01593_Cbac_239627871            60   ANILEISSKST----SALGVSLSAFN----LNIQTAK-----------------RAFSVECAFQSSK--VF-----------------ESGGPYTDLLDR-------SSIEAKKDPRLHD-------------------SGKLIAFQYFNVK---FPLEPKDYFYNWLYINALKL--------------------------NTELTSEIITY--------DSFSDIEFNP-------QKSINCQA-----------------------------------KAAAIFVSLSNQHLIEEAL  211  239627871  bacteria>firmicutes                            
bcere0015_42140_Bcer_229129773       46   ESVLEVSSKSE----SDLGRALSAFN----LKIELKNG----------------KNFSVENAFQASK--VF-----------------EFGGPFLDLLYC-------TAKEAKKDVRLKN-------------------SGNLISFRYFNRE---WPLCPKTAFYDWLYINALAR--------------------------QQKLGSCVLEY--------SAFSDIEFNP-------KKSINCQA-----------------------------------RALALYVSLHKADKLQYVL  198  229129773  bacteria>firmicutes                            
BC4488_Bcer_30022569                 32   ESVLEVSSKSE----SDLGRALSAFN----LKIELKNG----------------KNFSVENAFQASK--VF-----------------EFGGPFLDLLYC-------TAKEAKKDVRLKN-------------------SGNLISFRYFNRE---WPLCPKTAFYDWLYINALAR--------------------------QQKLGSCVLEY--------SAFSDIEFNP-------KKSINCQA-----------------------------------RALALYVSLHKADKLQYVL  184  30022569   bacteria>firmicutes                            
Ilyop_1055_Ipol_310778851            52   ANILEISSKSL----ENLGIKLSAFN----LMIQTKKG----------------KAFSVECAFQGSK--VF-----------------KKGGPYIDLFHK-------TSREAKKDPRIKN-------------------SGPLVKFEYNKNE---WSLEPKTFFYDWLYINSLYR--------------------------KNELAQEIIKY--------DSFTDIEFNP-------EKSINCQA-----------------------------------RAAALFVLLKKLNIIDNAM  204  310778851  bacteria>fusobacteria                          
OA238_4610_Oant_254453984            34   HPILEISTKSL----VEVGRRLSAFN----LKIDV-NG----------------TLKSLESVYQSSK--VF-----------------AHSGQHEHLMDL-------EPFMAKREVHSLG-------------------QGPIVAFRLLGEE---FPTEPKNAFYDWLYLKAITP--------------------------HEEWIKKNLHY--------AAYSDIEFNP-------SKSINCQG-----------------------------------RAVAEFHALSLRNSTMDCV  185  254453984  bacteria>proteobacteria>alphaproteobacteria    
ED21_31874_Esp._149186578            34   EKILEISSKSL----EDLGVRSSAFN----LKWLSSVA---------------NFPISVECAFQGSK--VF-----------------LNGGPFTDLYEA-------RPIDAKRDVRLRS-------------------SGNLKAFDFDGGN---WPIEPQTAFYDWLYISALRE--------------------------NPEIADAILSF--------DGFTDIEFNP-------KKSINCQA-----------------------------------YSAALFCSLYKQGMVDEVL  187  149186578  bacteria>proteobacteria>alphaproteobacteria    
CAP2UW1_1710_CAcc_257093308          52   AHILEISSKSE----DPLGVKLSAFN----LPFVMPNG----------------LRTTVENAFQSGK--VF-----------------RHGGPYLDLLNK-------TPREAKKDSRLSG-------------------SGDLVGFRLDGED---WPTRPLTAFYDWIYLSALKQ--------------------------SPALAEQLLRF--------DGFTDIEFNP-------ERSLNCQA-----------------------------------ASAALFVALTKRGEIDAAT  204  257093308  bacteria>proteobacteria>betaproteobacteria     
GBP346_A3087_Bpse_237813318          23   NDLLEISSKSP----NPDGVALSAFN----LKFTTLKY---------------NRTFSVEIAFQASK--VF-----------------EHGGPYRELLEV-------DSRTAKRDVRLKT-------------------SGRLLKFSFLKTE---FPLRPVTYFYDWLYINALVK--------------------------NRHLWPALSRA--------EGFTDIVFNP-------SKSLNCQA-----------------------------------YSAALFASLVRADKLSKAL  176  237813318  bacteria>proteobacteria>betaproteobacteria     
BCAM1881_Bcen_206563730              53   DRVLEISSKSK----DEYGVKLSAFN----LMIKTPR-----------------REYSLECAYQASK--VF-----------------ERGGPFTDLLNA-------KSIDAKRDPRLTQ-------------------FGRMIRFQWYGKE---WPLQPRTAFYDWLYINALHR--------------------------PQELAKIVLTY--------RAFSDIAFNP-------ERSINCQA-----------------------------------YAAALYVSLHERGLLRDEI  205  206563730  bacteria>proteobacteria>betaproteobacteria     
NEISUBOT_05210_Nsub_261381097        53   GKVLEISSKSK----SELGIALSAFN----LMIKSAKG----------------KRVSVECVFQSSK--VF-----------------EGDIQYLDLLEV-------SSREAKKDSRLKS-------------------SGMVIAFRTYGKKDKEWGTKPITAYYDWLYVNALNQ--------------------------HTEFHEELLEY--------SAFSDIEFNP-------EKSLNCQA-----------------------------------YSVALFCALYRRGILQDVL  208  261381097  bacteria>proteobacteria>betaproteobacteria     
Glov_2583_Glov_189425639             53   TNLLEISSKSK----TTLGVDLSAFN----LMITTIKY---------------NKTFSVESAFQSSK--VF-----------------EKGGPYLDLLDK-------TSREAKKDGRLQT-------------------SGRLKCFKFFGIE---WGLEPQTAFYDWLYINALKK--------------------------NSDYAEQVMEY--------SAFTDIEFNP-------ERSINCQA-----------------------------------YSAALYVSLCHRDLLEYAT  206  189425639  bacteria>proteobacteria>deltaproteobacteria    
HWAG_01373_Hwin_237752248            56   AKILEISKASP----NQLGQKLSAFN----LKLKVFNGIQ-------------DITASVERFFQGSK--VF-----------------NNGGPFEEIIFN-------ENIHPKKYDKLKK-------------------GCNFQGFKLFGKC---YSTEPVTFFYDWLYINALKQ--------------------------NSILATELENY--------DIFTDIEFNP-------NKSLSCQA-----------------------------------ATVALFLSLKKAGTLDKAT  211  237752248  bacteria>proteobacteria>epsilonproteobacteria  
CAMGR0001_0616_Cgra_257460202        53   EKILEISKASP----NPLGKALSAFN----LKLRLKDEEQN------------LIEASVERFFQGSK--FF-----------------ERGGPFEEIIFS-------AKVHPKKYPPLKN-------------------SGNFCGFELFGER---FSTEPKTYFYDFLYLSALKQ--------------------------NPNLADEVLRY--------DYFSDIEFNP-------KKSFSAQS-----------------------------------RAAALFVGLSRNGIFKEIF  209  257460202  bacteria>proteobacteria>epsilonproteobacteria  
Psyc_0321_Parc_71064897              53   DKILEVSSKSK----EDLGVALSAFN----LMIADKAT---------------KEKYSVECAFQSSK--VF-----------------ENGGAYTDLLKV-------TSKQAKKDERLRN-------------------SGKLIGFEFYNTK---WQLNPLTAFYDWLYVNALNQ--------------------------NVQLHDRLMQY--------QTFTDIEFNP-------KKSINCQA-----------------------------------YSIAMFVALAKRNMLESIR  206  71064897   bacteria>proteobacteria>gammaproteobacteria    
ACICU_00103_Abau_184156423           53   FNILEISSKSE----VELGVALSAFN----LMMFDKKT---------------HQKFSVECAFQSSK--VF-----------------QNGGPFLDLLNV-------TSREAKKDERLKT-------------------SGQLKKFTFYGID---WALDPLTAFYDWLYINALNF--------------------------NAEYHQELLAY--------EAFTDIEFNP-------EKSINCQA-----------------------------------YSIAMFVALSKRNLLDKVR  206  184156423  bacteria>proteobacteria>gammaproteobacteria    
HMPREF0198_1779_Chom_258545510       63   KNILEASSKSE----QPLGLPLSAFF----LK--DEDG------------------VPVENLFQSSK--VF-----------------ENGGAFLDLRHV-------SPRAAKKDLRLKE-------------------SGAMLKFLFNGKE---FPLEPKSLFYDWLYSKILYG------------------------NNNIELKNQLINE------VFDAFSDIEFNP-------KKSFSCQA-----------------------------------RTLALFISLHSTNCLKEFI  216  258545510  bacteria>proteobacteria>gammaproteobacteria    
Pcryo_0891_Pcry_93005719             60   NHVLELSSKSG----NKLSFLLSPLS----LKLTNENG---------------GEQYSVENAFQSSM--VF-----------------EDGGPYIDLLSA-------PPRQAKKDERLIN-------------------SGELIGYNYFGME---WSVEPLTTFYDWLYVNALKQ--------------------------NPHLHEEVMQY--------QAFTDMEFNP-------KKSIHGAA-----------------------------------YALAMFVALHKRELLDNIE  213  93005719   bacteria>proteobacteria>gammaproteobacteria    
Psyc_0844_Parc_71065404              67   NHVLELSSKSG----NKLSFLLSPLS----LKLANEHG---------------GEQYSVENAFQSSM--VF-----------------EDGGPYIDLLTA-------PPRQAKKDERLIT-------------------SGELIGYNYFGME---WSVEPLTTFYDWLYVNALKQ--------------------------NPQLHEEVMQY--------QAFTDMEFNP-------KKSIHCAA-----------------------------------YALAMFVALNKRELLDNIE  220  71065404   bacteria>proteobacteria>gammaproteobacteria    
GPB2148_1261_Mgam_254482777          24   EGILEISTKSP----ESLGVSLSAFN----LTYQPENS---------------DKRYPLESLFQSAK--VF-----------------TDGGPYRDILSK-------PAREAKSDPRLTT-------------------SGRLVAFSSRDTT---WPLVPRTAFYDWLYLNVLGH--------------------------YPRLAEPLSMF--------GGFTDIEFNP-------KKSINCQA-----------------------------------YSAALFVALSERKLMAKAM  177  254482777  bacteria>proteobacteria>gammaproteobacteria    
XAUC_02590_Xfus_294664143            60   DRVLEISSKSP----DSLGVDLSAFN----LMIKTVKH---------------EREFSLECAFQASK--VF-----------------ENGGPYKDLLNA-------RSLDAKRDPRLKE-------------------SGRLIKFRFFNVD---WELEPRTAFYDWLYINALHK--------------------------PQDLAEKVLTY--------RAFSDIAFNP-------DKSVNCQA-----------------------------------YAAALYVSLQERGLLSETM  214  294664143  bacteria>proteobacteria>gammaproteobacteria    
V12B01_14190_Vspl_84392320           54   GSILEVSSKSL----DELGVSLSAFN----LCITTKLK---------------KQSFTVETAFQGSK--VF-----------------EQGGPYLDLIGM-------DSRAAKKDLRLKE-------------------SGNLIYFEFFGKK---FPNTPRTFFYDWLYINALVQ--------------------------NQDLAIQVEAY--------DAFSDIEFNP-------KKSINCQA-----------------------------------YAIALYVSLAKNGLLEQAL  207  84392320   bacteria>proteobacteria>gammaproteobacteria    
A5C_A0388_Vcho_153817467             52   NNILEISSKSL----DELGILLSAFN----LSFVTKKH---------------NHKITVESAFQGSK--IF-----------------KRGGPYKDLYLA-------DSRTSKKDIRIKD-------------------SGQLVGFKFFNTE---FPLIPRTYFYDWLYIKALVS--------------------------NPQLVDQLYKF--------DGFSDIEFNP-------KKSINCQA-----------------------------------HAAALYVSLNSAGVLEEAL  205  153817467  bacteria>proteobacteria>gammaproteobacteria    
PsycPRwf_1182_Psp._148652988         60   KNVLELSSKSG----NKLSFPLSPVS----LKITNEED---------------GQQYSVENAYQASK--VF-----------------KGGGPFVDLLDA-------APRQAKKDERLMS-------------------SGEITGYDYFGMV---WGLEPLTVFYDWLYVNALKQ--------------------------PNHLHQEVLQY--------QAFTDISFNP-------KKNVHCPA-----------------------------------YSLAMFVALHKRELLEGIE  213  148652988  bacteria>proteobacteria>gammaproteobacteria    
FPR_02440_Fpra_295103146             48   VSILEVSSASA----QPEGEAVSSLR----LLLRLNSV---------------AQDVPISTVFEAAK--VF-----------------EHGGPFADLLTC-------APSKVHKDTRLRT-------------------NGKLLRYSLEGSEY--PIEPHPDSFFEWLYCRALKQ--------------------------PFEKAAQLSRY--------NAFSDIAAAA-----DSKKYYGDSS-----------------------------------RAAAIYVGLAAAGKLPCID  204  295103146  bacteria>firmicutes                            
_Fpra_160945657                      72   VSILEVSSASV----QPEGEAVSSLR----LLLHLDSV---------------AQDVPISTVFEAAK--VF-----------------EHGGPFADLLTC-------APSKVHKDTRLRT-------------------NGKLLRYSLEGSEY--PAEPYPDSFFEWLYCRALKQ--------------------------PFEKAAQLSRY--------NAFSDIAAAA-----DSKKYYGDSS-----------------------------------RAAAIYVGLAAAGKLPCID  228  160945657  bacteria>firmicutes                            
KSE_10250_Kset_311894452             22   AVIVDTTSKAP-----DPWVRLSPFYPHGGIPVPFSPG---------------VTAQSVEGIWQALK--VF-----------------ESVDTDPAKLDV------TTMKGLKRTVRRFG-----------------PVRGHRAGLDGTELL---PYQEARRRIYLPAYRWTLEH--------------------------VRPDLLERLRA-----EEHLVLLDYTTNG-------DVADTGSP-----------------------------------LSHAALIRRHLEGRWPDEG  186  311894452  bacteria>actinobacteria                        
OSCT_1675_Otri_309791192             22   ATLLDVTSQGP-----APWVRFSPFYPHGAIPVPLSPG---------------MTAASVEGIWQGLK--VF-----------------THANIDLNTMTN------TTMRGLKRTTRRFG-----------------AVQGHRAGVAGTTLL---DYATARQRIYLPAYRWVLDH--------------------------LCQPELDDLRQ--RASQGLVVLLDYETNT-------DLADLRRP-----------------------------------LSHAGLIIRYLDGTWPVS-  184  309791192  bacteria>chloroflexi                           
Tcur_0355_Tcur_269124625             22   ALILDVTSRAE-----RPWARFSPFYPHGGIPVPFSPG---------------VTAQSVEGIWQALK--VF-----------------ANADVDPAKLEI------TTMKGLKRTVRKHG-----------------PVRGHRAGLTGEVLL---PYEQARRQIYLPSYRWVLEH--------------------------VRADLMDRLKE--LSSRGDIVLLDYTTNG-------DVTDLSAP-----------------------------------LSHAALIRCHIEDRWP---  182  269124625  bacteria>actinobacteria                        
HCH_04340_Hche_83647036              29   YAIIDVTSKAS-----APWVKFSPFYPHSGIPIPFSS----------------ETAQSVEGIWQGLK--VF-----------------EGQDIDPSRFDI------TDMKGIKRTVRRYG-----------------RVLGHRKGPGGE-LI---PYIEARKQIYLPAYHWTLTH--------------------------LRQAELSQLSE-LLARHEGLVLLDYETNT-------DINDPRKP-----------------------------------LSHAALIRRFLQP------  185  83647036   bacteria>proteobacteria>gammaproteobacteria    
Caci_4610_Caci_256393748             22   ARIIDVTSKGP-----QPWVRMSPFFPHSGIPVPLSDG---------------AVSQSVEGIWQALK--VF-----------------PGSDVDPRKLDV------ASMTGLKRTVRKHG-----------------PVLGHRAGLNGQDLL---PYEQARRRIFLPAYRWVLEH--------------------------VNTDLIAELRA----ADGDIVLLDYTVNG-------DVTDTSSA-----------------------------------LSHAALIRLYVEDRWP---  180  256393748  bacteria>actinobacteria                        
M23134_02260_Mmar_124004845          21   YKIIDVTSKAP-----TPFVKLSPFYPIGDIPVPLSEG---------------HFAQSVEGIWQGLK--VF-----------------ETASIDLKKLEV------TTMKGLKRTVRKFG-----------------NVKGHQAGVNNHNLL---PYIIARKQIYLPAYRWVLDH--------------------------VKSDVLQLIKN--EAEQHPIILLDYETNG-------DVENASKP-----------------------------------LSHAYLVKYYLENNFP---  181  124004845  bacteria                                       
_Krac_298250178                      22   VQVIDVTSRGA-----DPWVRFSPFYPHGDIPVPFSPG---------------YTSWSVEGVWQGLK--VF-----------------EQAGVDVSKFRI------ANMKGIKRSGRSLG-----------------GVLGHREGVDGERLL---GYREARSAIYLPTYRWVLEH--------------------------LEQPELETLRQ--LSAQASVILLDYETNA-------NIDDLRRP-----------------------------------LSHAALIKAYLTAPED---  182  298250178  bacteria>chloroflexi                           
GobsU_010100001512_Gobs_168698168    22   ATVADVTSKGP-----EPWVRFSPFFPHGGIPIPNTPD---------------ETAASVEGLWQGLK--VF-----------------EKEDIDPKKWAI------TDMRNIKRAGASRG-----------------AVRGHRFGVGSGTLL---GYREARFRIYLPAYAWVLER--------------------------LCAREVEQLRG--IARAGTVVLLDYETNT-------DAEDLSRP-----------------------------------LSHAALVRHFLEETWP---  182  168698168  bacteria>planctomycetes                        
GobsU_010100034385_Gobs_168704676    25   SVVYDVSSYAE-----PPHCELSPMWVHGGVPVPGAPG---------------ETSDTVEGVWQGLK--VI------------------RGQTAPRYFR---------GPGAKRGG---------------------KPSGHRFGTR---LL---GVVEARRLIYVPTYEWVIEN--------------------------TRSPEQIRAFIDAAFAGVTQHFHDVGDNG-------DPNDATQP-----------------------------------LAQAAVLVRYLNRKCAERA  182  168704676  bacteria>planctomycetes                        
BXY_40670_Bxyl_295087466             21   AVILDITSNSE----TRYAKILSPFYPHGNIPIPFTDG---------------LKATCVEAVWQGLK--VF-----------------EGVGVDFATFKN------DTMRDLKRTVRKYG-----------------VPKGHSKGAYSKELL---GYFEARMLIYLPTYKWVLDN--------------------------PVEVHHVVERIKEQSKIQDIVLLDYNTNI-------DFRDISKP-----------------------------------MSHAGLVKLYIEGKYPDNM  191  295087466  bacteria                                       
HMPREF0665_01551_Pori_299141967      21   ADILDITSNSE----TRYAKILSPFYPHGNIPIPFTNE---------------LKATCVEAVWQGLK--VF-----------------DSVDVDFSTFKN------DTMRNLKRTVRKFG-----------------KPKGHRKGAYGKELL---NYFEARMLIYLPTYKWVLDN--------------------------PVEVHRVVERIKEQSKKRDIVLLDYNTNT-------DFRDISKP-----------------------------------LSHAGLVKLYIEGNYPEGM  191  299141967  bacteria                                       
Bfra3_010100013815_Bfra_255010211    21   AVILDVTSNST----MRYAQILSPFYPHGNIPIPFTPD--------------TLKATCVEAVWQGLK--VF-----------------ENADVDFSTFKN------DTMHNLKRTVRKFG-----------------IPLGHRKGAYGKELL---GYFEARMLIYLPTYKWILDN--------------------------KIEVYHVVERIKAQSIKQDIVLLDYNTNI-------DFRDITKP-----------------------------------LSHAGLVKLYIEGKYPNEV  192  255010211  bacteria                                       
Bcep1808_6822_Bvie_134288349         18   AVVVDTTSRSA----TSWSRAFSPFYL---GPADLYDG---------------HVARTVENGWQYAK--VY----------------ADQLGADGNPNEAYWAWAKAGWGKMRADRYPRG-----------------KGAKPVFCWWNGTKL---GYIEARLKVYFPLYRDAV-R--------------------------TQEAFNQLVRL---ARDRTIVLWDFDGF--------DHQTIGLS-----------------------------------LANVLLDDSRPMGHA----  179  134288349  bacteria>proteobacteria>betaproteobacteria     
bthur0002_58540_Bthu_228982721       89   LNVLECSTKGD--------KRFSALS----AKVSVHDV-----------------FDTIENHYQKSK--VF-----------------QDESGFYYTCKKW------ENAKGKKPVA---------------------------CKIGNTIL----SIEYLSMFYELLWYKYLKS--------------------------ENYLEEVLAKF--------DEYHDMFKS--------KKSMVCQA-----------------------------------DTIREYMKNENDEWY----  221  228982721  bacteria>firmicutes                            
MexAM1_META2p0262_Mext_240141986     7    APFLECSSRGD--------QRFSAFS----ARLR-SQG-----------------GRSIEEVYQAAK--VF------------------EDGSTGLGWR---------DAKGKRAVN---------------------------------------MPEVRR-LYSRLWDAYIDE--------------------------PNELLALIQVQ--------SGLSDVFG---------QQGNACQA--------------------------------------TELWRIRAERAAVGGV  125  240141986  bacteria>proteobacteria>alphaproteobacteria    
16-3p043_BP16-3_195546573            7    APFLECSSRGD--------RRLSAFH----ARIR-SRG-----------------NKSIEDIYQAAK--VF------------------ADGSSGLSWR---------EAKGKRAVN---------------------------------------MAEVRE-LYARLWDEYIGE--------------------------PNALLDVVRAA--------SGLSDMFG---------QSGSACQA--------------------------------------TELWRIRNKEQA----  121  195546573  dsdna viruses, no rna stage>caudovirales       
MAR_ORF111_MV_284504143              1    ------------------------MAL---GPVEHVHPA-------------LPPAKNIENFYQGSK--VF--------------VQEVDKDQNPTSLFYENRERLFSDEIPKRHKYKGMGKN--------------KNIPLYFLWTDKCGK----EHRLDYIQSRQTYCNFFER--------------------------ALSDTEDYRKL--------CRLQDKGYNLIFCGY--DAHDIPEDTPKI-------------------IEEAYLDPSVPF-GHERVLFAMLALRDTPEE  169  284504143  dsdna viruses, no rna stage
LAU_0089_LV_327409634                109  FPNFRHQKRKD----GFGCSNLSPMTL---GPVKHTCPG-------------LEPAKNIENFFQGSK--VF--------------SEEVDKHKNPSSLFYENREMLFADPVPKRHKYKGVGKN--------------KNIPLYFLWTDSEGK----EHRLSYIESRQTYCNFFER--------------------------ALSETKDYRKL--------CRLQDKGYNLIFCGY--DAHEITGS-----------------------IEDAYLDPSVPF-GHERVLYAMLALRDTPEE  284  327409634  dsdna viruses, no rna stage
NAEGRDRAFT_46602_Ngru_290997341      83   YKNVNCCSGAS----GI-FKELSPMKL---GPYEYEHGSE------------KCTITNLENLWQFSK--VF-----------------PGEEEQVRN---------DNGQLTKVPNSEFF-------------------ERRTKGWKDEKAH---RHVKREKPLYSWWKGEKFNY--------------------------QMARRKIYCPL------YAEKVVETEAYK-------KLEEMVNS------------------------------------GMNIQILGFDGYNYDGKT  240  290997341  eukaryota>heterolobosea                        
consensus/100%                       -    ...hp.sp..............ush.................................lp..hb..b...b.........................................p...................................................h...b...h.................................................h.c............p.............................................................
consensus/95%                        -    ...lphoo.............hSsh.......h........................slp.hab..K..hh.........................................+p.................................................ha...h...l.................................................h.-............p......s......................................................
consensus/90%                        -    ..hl-hoo.u...........hSsh.......h........................slE.haQu.K..la...................ss.....b..............K+.................................................ha...a...l.p...............................................h.Dh...........p....s.s......................................sh..b...........
consensus/85%                        -    ..ll-loo.u...........hSsh.....h.h........................slEshaQu.K..VF...................ss.....h.............hK+..p.......................s........s...........p.hY..hY...l.p...........................p...................h.Dh..s........p....s.s......................................shhhb..b........
consensus/80%                        -    ..lL-loSpu........s..hSsF.....l.h........................slEshaQu.K..VF.................p.ss...pbh.........s...hK+s.c.......................s....h...s.p.......sbp.hY..hY..hL.p...........................p.....l.ph.........sh.Dhp.N........p.s..sps......................................shhhb..l........
consensus/75%                        -    .plL-lSSpS........u..hSsF.....l.l..ps....................oVEshaQu.K..VF.................ppuss..pbh.........s.bphK+ssR..s....................s....h...s.p......psbp.hY.bhY..hL.p...........................pph...lbph.........sh.Dhp.Ns.......cbs.ssps......................................uhhhbh.l........
consensus/70%                        -    .plL-lSS+S........u..lSsF.....l.l..ps....................oVEshaQuuK..VF.................cpuss..shhp........ssbphK+ssRbbs...................ssp...h.h.spp.....bpsbp.hYpbhY.phLpp...........................pph..plbph.........shsDhp.Ns.......cbs.sspu......................................uhhlhh.Lp.p.....

#==== YbiA-like family

#== gp30.3
_Bpar_33595978                       4    ASRLNISSTSD----DWRGLALSNFPL----SPFVLDG---------------ELFASVEGFIQGIK---FR----------------EDDPRRATAFLS-------SGWDAKHLGD--------------------TVDRSGAYWGGARIRY---GSAEHHQLIERAIRARIKQ--------------------------CEGLRRTLRAT------EGMTLVHDTGKP-------EAPHTSLPAT-------------------------------------VFCRILETLRREILA  152  33595978   bacteria>proteobacteria>betaproteobacteria     
_Bbro_33601359                       4    ASRLNISSTSD----DWRGLALSNFPL----SPFVLDG---------------ELFASVEGFIQGIK---FR----------------EDDPRRATAFLS-------SGWDAKHLGD--------------------TADRSGAYWGGARIRY---GSAEHHQLIERAIRARIKQ--------------------------CEGLRRTLRAT------EGMTLVHDTGKP-------EAPHTSLPAT-------------------------------------VFCRILETLRREILA  152  33601359   bacteria>proteobacteria>betaproteobacteria     
30.3_BPRB43_66391541                 1    M-DIGSGSQY-------PSCALSNFAP----HPFTFDG---------------VECASMEGFLQSLK---F-----------------SNPDMQAHVCTL-------VGKAAKFKGKKKK-----------------WWTTQTLYWKGIPIHR---ESEAYQILIENAYNALFL---------------------------NEGFRRALKAT------GKSTLTHSMGKN-------KMNETVLTER-------------------------------------EFVRNLTRLRDLL--  146  66391541   dsdna viruses, no rna stage>caudovirales
BMS_2150_Bmar_301167374              62   EGEVILSKRN-------ELGILSNFAA----TDFVYKG---------------TLYKSVEGFWQSLK---YP-ESQDDMRATF--EGIEWPYSRAEVELM-------TGFLAKKAGGYAN-------------ANMREMGIDWVTFQGKKIKFWTVSKGVHYRLIKDALRTKAIQ--------------------------NPKVMEILLST------GDLKLLPDHIMG-------DAPPAWFYNK-------------------------------------IWMELRKEFRE----  228  301167374  bacteria>proteobacteria>deltaproteobacteria    
PT7_2661_Psp._332285914              5    DTHLNVAYTST----DWRGVALSNFSL----SPFVFDD---------------QLFASVEGFIQGLK---FP----------------EGDARREQAFQS-------CAWEAKKIGE--------------------QADKSAAYWAGECMAF---GSTEHHRLVGRAVRVRIEQ--------------------------SQGLCQVLIST------KGLELVHETGHG------PEPAITSLPAA-------------------------------------VFCRVLTDLRGELLA  156  330429867  bacteria>proteobacteria>betaproteobacteria     
Gbem_1485_Gbem_197117872             1    M-DVGGYTTG-------IAGRLSNFTP----RAFVLDG---------------FHCACLEGALQAFK---F-----------------DDPEMQKRICMM-------SGKEAKTIGQTRN---------------EAWQSCQTLWWQGKAYDR---LSPEYQQLLDRLYEAALL---------------------------SADFADDLLAT------GDEVLSHSIGEH-------DPRKTVLTEE-------------------------------------EFCSRLMANRSKVKK  150  197117872  bacteria>proteobacteria>deltaproteobacteria    
gp30.3_BPSP18_308814565              1    MSELEIRSNF-----PWPSCALSNFAK----WPFVMDG---------------IQFGGLEGFLQGCK---V-----------------RNCEQQKRIFGM-------SGLTAQQTGRAYA----------------RAADRGTLFWLGIPFSR---YSTSWKELYTNAYFEAALQ--------------------------NKGFRDALQAT------KGKVLKHSMASH------LTVHDTILTEQ-------------------------------------EFIDILNQLRDAL--  152  308814565  dsdna viruses, no rna stage>caudovirales       
30.3_BPIME08_299779149               4    MSELEIRSNF-----PWPSCALSNFAK----WPFVMDG---------------IQFGGLEGFLQGCK---V-----------------KNVEQQRRIFGM-------SGLAAQQAGRAYA----------------RAQDRGTLFWLGTPFSR---YSTAWKELYESAYFEAALQ--------------------------NKGFRDALQAT------KGKVLKHSMASH------LTECDTILTEK-------------------------------------EFIDILNKLRDLL--  155  299779149  dsdna viruses, no rna stage>caudovirales       
30.3_BPAeh1_38640191                 1    MLDIHIGTAY-------PGNVLSNLAH----NAFVFDD---------------IRCGGMEGLLQSLK---F-----------------QDVNKQIQIAAM-------SGTAAKFRGAKKK-----------------WYNGQTLYWKGVPFSR---HTDAYQNLLDNAYDEMFVQ--------------------------NESFRKALTDS------KNTVLCHSIGHT-------DPFRTILTVE-------------------------------------EFLCRLNRLRSLLLV  150  38640191   dsdna viruses, no rna stage>caudovirales       
phiAS5_ORF0053_BPphiAS5_310722519    1    MLDISVSALY-------PANELSNLAK----HEFIFDG---------------VRCGSMEGLLQSLK---F-----------------QDVEKQIAIAAM-------WGTGAKFRGAKKA-----------------WYNDQTLYWKGVPFSR---HSEAYQNLLDNAYDELFVQ--------------------------SESFRKALTSS------GNTVLCHSIGHN-------DPMRTILTVE-------------------------------------EFLCRMKRLRSLLLA  150  310722519  dsdna viruses, no rna stage>caudovirales       
30.3_BPKVP40_34419305                1    M-DIKSGAGY-------PASALSNFAP----HAFVVRG---------------VECASMEGFLQSLK---F-----------------KNPEMQREVCKL-------VGKVAKARGSKKN-----------------WQRTQTLYWQGEPIQR---ASVGYQTLLDDAY-AALAQ--------------------------NVKFQKALLAT------GKATLTHSIGRK-------KQAETVLTVQ-------------------------------------EFCSRLTVIREHLQN  148  34419305   dsdna viruses, no rna stage>caudovirales       
30.3_BP65_326536778                  1    VIDI-YSGSS-----NWIERELSNFTE----HTFTFDG---------------VYYRTIEAFLQSLK---Y-----------------ENPPDINGLRGH---------EVYRFCHNHIG-----------------WKKDLTMWYKGRPIHR---LSDAYSNLIYNAYLSMAEQ--------------------------NKSFLEALVHS------KPHILAHTMGCK-------DPHHTILTEK-------------------------------------EFCDILTEIRELI--  149  326536778  dsdna viruses, no rna stage>caudovirales       

#== YbiA
ALIGN                                -    ---EEEE--------------------------EE----------------------HHHHHHHHHH-----------------------HHHHHHHHH----------HHHHHH---------------------------------HHHHH---HHHHHHHHHHHHHHHHH-----------------------------HHHHHHHHH----------EEEEE------------------H-------------------------------------HHHHHHHHHHHHHH---
HMM                                  -    ---EEEEE-------------------------EEEE----------------EEE-HHHHHHHHH------------------------HHHHHHHHHH--------HHHHHHHHHH-------------------------HEEH-HHHHH---HHHHHHHHHHHHHHHHHH---------------------------HHHHHHHHHH----------EEEE------------HHHHHHHH-------------------------------------HHHHHHHHHHHHHHHH-
FREQ                                 -    --EEEEE--------------------------------------------------HHHHHHHHHH-----------------------HHHHHHHHH----------HHHHHH---------------------------H-HHHH-----------HHHEHHEHH-HHHH-----------------------------HHHHHHHHH---------EEEEE--------------EE------------------------------------------HHHHHHHHHHHHHH--
PSSM                                 -    ----------------------------------EE----------------------HHHHHHHHH-----------------------HHHHHHHHH---------HHHHHHHH-----------------------------------------HHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHH---------EEEEE--------------EE-----------------------------------------HHHHHHHHHHHHHH---
FINAL                                -    --EEEEE---------------------------EE-----------------EE--HHHHHHHHHH-----------------------HHHHHHHHH---------HHHHHHH---------------------------HHHHHHH-------HHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHH---------EEEEEE-------------EE-----------------------------------------HHHHHHHHHHHHHHHH-
PDB(2b3w)                            -    --EEEE-----------HHHHH-----------EEE-----------------EEE--HHHHHHHHH-----------------------HHHHHHHHH---------HHHHHHHHH----------------------------H-----------HHHHHHHHHHHHHHHHHH---------------------------HHHHHHHHHH---------EEEE----------------------------------------------------------HHHHHHHHHHHHHHHH                                                                                                                                                                                                                                                                                                                                                                                                                                   
                                                                                                                                                                                                                                                                                       #                                           #    #      #                                                                                                                                                                                                                                                                                                                                                                                                                                         
IIV6gp151_IiV6_15078868              19   -DTIVLKHEE-----DKPFGPLRNDYK----SDLYIDG---------------KRWNSVDNYVFSNL---L----------------PSIDFRKQTIEHL-------NPHQVEKTYYDV-----------------------KFEIN----------KSTLSSAIKIGIESKLIA--------------------------DPQFRQALLNT------AGSSIMYLSKNN-------YLGYGNGKWF-----------------------------------VNTYGIWLEHFRTGMLW  159  15078868   dsdna viruses, no rna stage                    
ORF234_BP0305phi8-36_156564215       7    SNAIRFYSGS------DNYSEFSCMSK----HPVVIAG---------------TEYPTLEHYYHAQK---F-----------------IDLEPVEEILAT------NNPFEARRLGQRTD-------------------YPIHEDW-----------DVMKEHVMFVGLIHKFKQ--------------------------HEWLRTLLLST------GDKELIHHSDR--------DRYWGQSVTG---------------------------------KGKNRLGIMIMNVRERIKN  151  156564215  dsdna viruses, no rna stage>caudovirales       
Deipr_2488_Dpro_325284428            43   QEVTSFTG---------PFSFLGNFHS----EKAVRYG--------------ALQFQTLEAAFQAAK---T-----------------GDVDIQRRIAAA------PSPKEAKAIGRALQ---------------------LREDW-----------EDMKEQVMLDLLREKFS---------------------------HRVYREQLLGT------GLVPLIHNNAHK-------DAFWGVYKGE----------------------------------GQNRLGKLLMQVREEIRA  182  325284428  bacteria>deinococci                            
TVAG_227690_Tvag_123462122           1    --MINIYYSTN------ENAELSNFAI----RPFIING---------------VRYDSVEQYFQIMK---FKIEAVYTYDKDSEEGRKSKEKIDSLIQKMQNT---KSGSLLKKLGNTRI----------------KNAKFNSGLW-----------TQESQNVMREGIFESFKQ--------------------------NPPFLKKLLET------GDATLTHNQDK------------------------------------------------SRW-GK-LFPKILMEVREQLKE  157  123462122  eukaryota>parabasalia                          
Mmc1_1181_Masp_117924481             22   PTMVALLPPI-------WYSCFSNFSD----HPFELDG---------------KLWFTVEHYFQAAK---F-----------------ADPQQRARIYAC------PSPMTAALMGKDRS-------------------IPIRADW-----------DAIKLDVMRQALNAKFDT--------------------------HQQIHDFLQAT------HPYPLLNYTAF--------DPFWGQDKRG---------------------------------HGQNQLGKLLMERRSRML-  164  117924481  bacteria>proteobacteria                        
Msp_0486_Msta_84489297               69   DAQELIKSTLK----PLFIKLWTRDGK----PKYNIDFN--------------EDKNYIQMYDTIYK----------------------DTTHHIHIGT-------KTYDSAKEIISLIE---------------NDLKSKSPELW-----------NELKYTLYLNALYYKIVT--------------------------DINFTKELIKT------KDRCIVFKSDN---------LEWGVTIDD------------------------------GKLIGQNLFGFAMMEIRDVLCD  219  84489297   archaea>euryarchaeota                          
SrosN15_010100002350_Sros_239939813  220  QLYQSYPNKPVA---DPGHRGLRNDYP----APITVGE---------------VLHPSVAHAYWALS---V-----------------AQPEVSSAITAA------DTAAAARKLAAAAP---------------------RREGW-----------EHSRTAVMTGLLRAKYDQ--------------------------HPELAEILLAT------DDATLIYDDME--------SAFWGDNAGR----------------------------------GRNWTGRLLELVRSELHL  364  239939813  bacteria>actinobacteria                        
LbrM06_V2.0110_Lbra_154331017        12   QNVVTFCEAH-----DPQYGVLSPLSP----SPLVVRH---------------VQYPSLHHYFLCER---F-----------------KGSPAEQWVTEA------TTVWSLDRLVKAAE-----------------AEGYQRSNW-----------NKVKVDVMLLGTYLKFKQ--------------------------NEAARAVLLST------HPSLLLYHTPK--------DDFWGDGGDG---------------------------------TGKNVLGVVTMTARARLHS  159  154331017  eukaryota>euglenozoa>kinetoplastida            
LinJ06.0130_Linf_146070759           8    QNVVTFSEVH-----DPLYGVLSPLSP----SPLVVRH---------------VQYPSLHHYFLCER---F-----------------KGSPAEQWMAEA------TTVWSLERLVKTAE-----------------EEGYQRHNW-----------NKVKVDVMLLGTYFKFKQ--------------------------NEAARAVLLST------QPSLLLYHTPT--------DDFWGDGGDG---------------------------------KGKNVLGVVNMAVRARLHS  155  146070759  eukaryota>euglenozoa>kinetoplastida            
Tc00.1047053507521.60_Tcru_71654521  3    KGVVRFHDVH-----EVPYGVFSPLSP----HPIVIRH---------------KQYPSVHHYFLTER---F-----------------RDAPVTAALRSA------TSVWELDRLVKEAE-----------------RTGSQREDW-----------NRVKVDVMLLGNYMKFKQ--------------------------NEAVRSLLLET------GDKLIIDHTTS--------DDFWGDRGDG---------------------------------SGKNLLGVILMAVRDRLRR  150  71654521   eukaryota>euglenozoa>kinetoplastida            
Tb927.7.4780_Tbru_72391614           3    KGVVRFHDSR-----EKPYGVFSPLSP----HPVTIHH---------------TQFPSLHHYFLTER---F-----------------GGLPDAAPFQSA------ASVWELDRLVRVAE-----------------REGRQRGDW-----------DRLKVDVMLLGNYMKFKQ--------------------------NENAREILMNT------GTRLIVDHTEE--------DDFWGDAGDG---------------------------------TGHNLLGVILMAVRDRLHR  150  72391614   eukaryota>euglenozoa>kinetoplastida            
TTHERM_00998900_Tthe_118397133       37   EQVIKFTHKLH-----DKYGFLSNLFQ----SKIMIDK---------------LQFMSVEHYYQAMK---F-----------------EGTKKFEVIRRA------GKAIDAHKLAQKKD-------------------TPKNRDW-----------QDLKVAYMKKAIQAKFQQ--------------------------NKALKKQLIET------YPNKLVDVTPG--------DKFWGIGDKE---------------------------------EGKNMNGQILMEIRE-LCM  181  118397133  eukaryota>alveolata>ciliophora                 
OSTLU_35648_Oluc_145348536           4    LPPVKFYKAW------DEYGALSNFSP----FPVSVDG---------------VEWPTVEHYYQAQK---FAGVH-----------NDIARESFEKIKLA------ESPEAAAKIGRSAQ---------------AAHPESVRKDW-----------DDVKVDVMRRALTEKLVR--------------------------YEGPRTLLMESVCTD--GRVRVIEDSPV--------DGVWGAGRDG---------------------------------TGQNLLGALLVNIREDLVS  162  145348536  eukaryota>viridiplantae>chlorophyta            
Plabr_0990_Pbra_325107565            1    --MILIRKVK------DEYGWLGNMSS----FPVLYEG---------------KKYRTTEALFQALR---F-----------------DHEKIIESIREQ------KSPMSAKMKAKKHR------------------NRMVVVPL-----------SEADLDNMRLVLRLKLLQ--------------------------YPKLRTLLLAT------GDQEIVEDCTKRPR---GSGLFWGAANRD------------------------------GKWIGENWLGRLWMELRTELTQ  152  325107565  bacteria>planctomycetes                        
PRU_0382_Prum_294673143              23   DKCACIRKTT------EEWGIFGNFFY----APIIVEG---------------VTIDCTERLFHLMK---FNA---------------NGEEGIKSEYAA------KRGMAIKMHMKPIY---------------KSHPEWLRNDW-----------GAMVVDAMRFCLQTKYEQ--------------------------CEAFRKELERS------KGLFIVEDETKRNEKKKADADSWGTNLVG------------------------------NEYVGPNLLGRLLMELRDNGKL  184  294673143  bacteria                                       
DICPUDRAFT_22458_Dpur_330798615      1    ---IKFFNNG------DPYYEFTNFYE----ACFNLDG---------------LYWKTSEHYYQAQK---FS----------------PNKAIMEQVRHL------PNPREAFKFGNFKG-----------------HKHFIRKDW-----------HDIKEEIMEKAIRAKFEQ--------------------------NSKLQNLLFKT------KGSELIENSPF--------DDYWGIGINN---------------------------------NGQNRLGVILMKVRDSL--  143  330798615  eukaryota>amoebozoa>mycetozoa>dictyosteliida   
DICPUDRAFT_35661_Dpur_330802814      24   SGELKFYSQG------QDFYEFTNFYE----SPFNLDG---------------KLWTTSEHYFQAQK---FS----------------PDQALIELVRNL------PSPREAFNFTRIPD-----------------LQKDIRKDW-----------QEVKYTIMCDALFAKFTQ--------------------------NNHLRKLLLST------DDMKLIENSPV--------DYYWGEGKDG---------------------------------TGENKLGEILMELRRNLKT  171  330802814  eukaryota>amoebozoa>mycetozoa>dictyosteliida   
DICPUDRAFT_42446_Dpur_330843562      24   SGELKFYNQG------QDFYEFTNFYE----SPFYLDG---------------KLWTTSEHYFQAQK---FS----------------PYQSLIEHVRNL------PSPREAFNFTKKPD-----------------LQIDIRKDW-----------HEIKDIIMYNALFAKFTQ--------------------------NHYLRQLLLST------GDMKLIEDSPI--------DNYWGVGKDG---------------------------------TGKNKLGETLMDLRRSLNM  171  330843562  eukaryota>amoebozoa>mycetozoa>dictyosteliida   
SELMODRAFT_413953_Smoe_302783817     153  STVIYFYKSW------DPYGAFTNFTA----HSIKLPGSS-------------ETWKSVEHYYQAQK---FSGVK-----------DELAMQAIENIRNA------ESPEEAARIGRRLA---------------RERPDLVRPDW-----------ENSKMDVMEEALVAKFSS--------------------------YPQLRSLLLST------AGCVLIESSPQ--------DYFWGSGKDG---------------------------------TGQNQLGRLLMKLRAAILT  309  302783817  eukaryota>viridiplantae                        
NPH_6632_Dpro_301059840              13   IDSVVFRKTI------EKFGGLSNMAP---GFPLQIGD---------------ISVRTSEALYQACR---FP----------------YAEEIQKMIISQ------KSPMTAKMKSKPFR-------------------SQTRPDW-----------DHVRVKVMRWSLRVKLAC-------------------------NWDKFRNLLLLT------ADKQIVEDSRR--------DRFWGAVAND-----------------------------EDYLEGENVLGRLLMEIREELKS  164  301059840  bacteria>proteobacteria>deltaproteobacteria    
PSYMP_06728_Psyr_330874307           12   SNSIVFLKTS------DEFGGLSNMAG---GFPLFVNE---------------RKILTSEALYQVCR---FP----------------HLPEVQCLIVSQ------TSPMTAKMRSKPFR-------------------SESRPDW-----------MRVRVRVMRWCLRAKLVQ-------------------------NWDRFSKLLLMT------EGLPIVEQSSK--------DKFWGASPQN-----------------------------DNKLVGANVLGRLLMELREDIVS  163  330874307  bacteria>proteobacteria>gammaproteobacteria    
PE36_21039_Msp._149908726            2    IDEIQFYEPN------DDFGFLSNFAL----AAVKIDG---------------VVWPSSEHFYQAQK---F-----------------NDPQLQDFIRTA------TTPDEAFSLSREYA-------------------QLVKSDW-----------MAVRDGVMRDVVMEKFSQ--------------------------NPFYAYQLVAT------GEQVLTEHSHK--------DAYWGDGGDG---------------------------------QGRNELGKILMNVRHQLAS  146  149908726  bacteria>proteobacteria>gammaproteobacteria    
VME_08600_Vhar_269960099             2    VDQILFYEPD------ESHGFLSNFCQ----AQIKVST---------------QSWPTSEHYYQAQK---F-----------------SDRELQDKILTA------KSPDEAFALSRKYQ-------------------HLVREDW-----------DDDKLSVMAFIVREKFLQ--------------------------NPQLAKQLMET------GNACLTEHSHK--------DAFWGDGGDG---------------------------------SGENHLGEILMNVRAELKH  146  269960099  bacteria>proteobacteria>gammaproteobacteria    
VPA0006_Vpar_28899861                17   VDQILFYEPD------EPHGFLSNFCH----APVEISS---------------QSWPTSEHYYQAQK---F-----------------VDAQLQTKIQKA------QSPDEAFALSRQYE-------------------HLVRSDW-----------DNMKLSVMAFIVREKFLQ--------------------------NPKLAQKLMRT------GNACLTEHSHK--------DAFWGDGGDG---------------------------------KGLNHLGEILMNVRAELRH  161  28899861   bacteria>proteobacteria>gammaproteobacteria    
VSWAT3_18363_Vbac_148975384          8    AEEVLFYEPE------DPNGYLSNFAA----CPIKVDG---------------QVWATSEHYYQAMK---F-----------------SSPSLRNMILEA------CTPAEAFSLSRQYE-------------------EQVREDW-----------YDIRVEVMRFIVTEKFTQ--------------------------NPQFALFLTST------GDSVIKEHSHK--------DHFWGDGGDG---------------------------------TGENHLGKILMAVRQQLRS  152  148975384  bacteria>proteobacteria>gammaproteobacteria    
GobsU_010100009074_Gobs_168699662    6    PRVINFYSVA------AEYGCFSNFSR----HPVFLRG---------------KRWPTTEHFFQAMK---F-----------------EGTEHEEQVRLA------KRPMDAASMGRDRK-------------------RPLRRDW-----------ESVKERIMMDGLRAKFTQ--------------------------HEELKAVLLGT------GDATLVEQTAN--------DSYWGDGGDG---------------------------------SGKNRLGYLLMRLREELRA  150  168699662  bacteria>planctomycetes                        
HCH_06997_Hche_83649602              4    KKTINFYLAN------GEYGCFSNFSR----DPVYLKD---------------KRWPTSEHYFQAQK---F-----------------AGTEHEEAVRMA------SKPMEAANMGRERT-------------------RPLRPDW-----------EAVKDDIMREAVMAKFVQ--------------------------HEKLTSILLGT------GDAELVEHTAN--------DRYWADGGDG---------------------------------SGLNMLGKILMEVREAIQQ  148  83649602   bacteria>proteobacteria>gammaproteobacteria    
sce3364_Scel_162451636               1    MTVIRFYRSG------DAHGFFSNFSR----HPVTLKG---------------KVWPTSEHYFQAQK---F-----------------PGTEHEEVIRNA------PGPGEAARMGRQRS-------------------RPLRPDW-----------EQVKDDVMREVVLAKFTQ--------------------------HEDLRRALLDT------GDAELVEHTAN--------DAYWADGGDG---------------------------------SGRNMLGVILMEVRAQLRR  145  162451636  bacteria>proteobacteria>deltaproteobacteria    
M23134_02266_Mmar_124004851          2    DNLIKFYSIG------APYGEFSNFAP----YPIKLKG---------------KVWATTEHYFQAQK---F-----------------VGTPHETKIRKA------ASPMKAAELGRTRK-------------------VRIRDNW-----------DHIKDNVMMEAVKAKFTQ--------------------------HADLQTLLLDT------GGATLIEHTEN--------DAYWGDGGDG---------------------------------KGKNRLGKILMKVREELKD  146  124004851  bacteria                                       
PM8797T_20343_Pmar_149175186         5    NQPVLFYSVS------EAYGEFSNFAE----YPIQVDG---------------KRWPTSEHYFQAQK---F-----------------TEVQHREAIRKA------PSPMQAARMGRDRK-------------------RPLRKDW-----------ESVKVAVMRTAVLSKFAQ--------------------------YEKLCMLLIST------GQRKIVEHTTN--------DSYWGDGGDG---------------------------------SGKNMLGRILMEVRSQLRE  149  149175186  bacteria>planctomycetes                        
HCH_04109_Hche_83646809              18   VEVIKFYSVN------DEFGEFSNFAQ----YPIKLKG---------------KVWPSSEHYFQAMK---F-----------------EEEKDRSDIRKA------KSPLEAARKGRDRK-------------------RKLRNDW-----------ESVKLNIMREAILAKFTQ--------------------------HDALRERLLST------GSAKIVEHTDN--------DDYWGDGGDG---------------------------------SGQNMLGRILEEVRAQLSE  162  83646809   bacteria>proteobacteria>gammaproteobacteria    
_Rbal_32471506                       31   SDPIKFYSTG------DEHGEFSNFAG----YPIKIGK---------------KVWPTSEHYFQAMK---F-----------------QEGSDQEEIRKA------NSPMQAARMGRDRK-------------------RKLRRDW-----------ESVKVNIMREAILAKFTQ--------------------------HEDLRELLLAT------GDAKIIEHTTN--------DDYWGDGGDG---------------------------------RGKNMLGRILMDTRTKLRE  175  32471506   bacteria>planctomycetes                        
YbiA.2b3w_Ecol_82407990              14   DTIINFYSTS------DDYGDFSNFAA----WPIKVDG---------------KTWPTSEHYFQAQK---F-----------------LDEKYREEIRRV------SSPMVAARMGRDRS-------------------KPLRKNW-----------ESVKEQVMRKALRAKFEQ--------------------------HAELRALLLAT------APAKLVEHTEN--------DAYWGDGGHG---------------------------------KGKNRLGYLLMELREQLAI  158  82407990   bacteria>proteobacteria>gammaproteobacteria    
VspiD_010100021915_Vspi_171913880    1    MEPILFYSTK------GTYGAFSNFSA----HPFVLNN---------------KRWPTTEHYFQAQK---F-----------------VGTEHEEAIRMI------ASPMVAARMGRSRQ-------------------RPLRKDW-----------DSAKDDVMRKALRAKFTQ--------------------------HQDLQSLLLST------GEAQLIEHTKN--------DSYWADGGDG---------------------------------SGKNRLGILLMELRDRLRS  145  171913880  bacteria                                       
Namu_1431_Nmul_258651665             1    MRIIEFYLHT------DPWGELSNFHP----APIHLDG---------------QRWPTTEHYFQAAK---F-----------------PGTPHAELIRLA------ATPDRAKQLGGDRA-------------------APLRADW-----------LAVRDEVMRTALRAKFTQ--------------------------HEQLRALLLDT------ADAQLVEHTVN--------DHYCGDGGDG---------------------------------SGVNRLGLLLMQVRAELS-  144  258651665  bacteria>actinobacteria                        
TTHERM_00486130_Tthe_118401008       12   NGHIYFYREY------EHNGIFSNFYA----SPIALKE---------------KQWPTTEHYFQAQK---F-----------------SGTEKEELIRLA------STPSESFKLGRQRD-----------------DEYPLRKDW-----------ESVKDEVMYEALKAKFTQ--------------------------HKDLQKFLLST------GDAKIIEHTQK--------DKYWADGGDG---------------------------------SGKNMLGILLMNLRNELKA  158  118401008  eukaryota>alveolata>ciliophora                 
TTHERM_00289300_Tthe_118370894       18   GNTIKFYGAK------NKNGLFSNFYI----SPIKLKG---------------KIWQTTEHYFQAQK---F-----------------AGTVKEEQVRNA------SGPGIAFRLGRKKS-----------------NDYPLRSDW-----------LKVKDDVMYEAIKAKFTQ--------------------------HDNLKKILLST------KNHKLIEHTKR--------DAYWGDGGDG---------------------------------KGKNMLGILLMKLRKELSE  164  118370894  eukaryota>alveolata>ciliophora                 
PTSG_01145_Ssp._326434983            1    MGAIRFYGHT------KPFGFMSNFYP----AKVVIDG---------------HTWPTTEHYFQAMK---F-----------------HDKDYQAQIRKY------SSPSTAKKLGQTRA-------------------VKLRSDW-----------EDVKYDVMYKACLAKFTQ--------------------------HADLRKQLLDT------GDAKLIEHTRN--------DRVWGDGGDG---------------------------------TGQNKLGQVLMEVRRELRE  145  326434983  eukaryota>choanoflagellida                     
PPL_02864_Ppal_281209628             3    RPTIYFYRAA------DAYGCFSNFSD----HPVMMDG---------------YIWPTSEHYYQAMK---FKT---------------TDIEYYHQIRDA------ESPARSFKMGNTYA-------------------HDKRRDW-----------NQIKDQVMYDVVLNKFLQ--------------------------NKDIQRN---T------GISKIVEHTRC--------DDYWGDGSDG---------------------------------NGRNQLGKTLELVREFIKN  146  281209628  eukaryota>amoebozoa>mycetozoa>dictyosteliida   
DDB_G0281625_Ddis_66812724           4    NNIISFYRST------DAYGCFTNFSW----FKVHFKN---------------HTFKTSEHAFQAFK---FE----------------HEQKIFFQILNS------KTASESKRIAHLNN-------------------DKKRKDW-----------ETIKDQIMYEICFEKFNQ--------------------------NDHLKLILLDT------GNLKIVESSEK--------DFYWGIG-DG---------------------------------SGRNQLGITLMKIREDLRK  148  66812724   eukaryota>amoebozoa>mycetozoa>dictyosteliida   
DICPUDRAFT_85573_Dpur_330846708      3    DNVINFYRAG------SGYGCFSNFSR----HTVFYKG---------------QKWPTSEHAFQAMK---F-----------------EGTDHFLNVLKT------KTPGDAAKMGRNRS-------------------LPLRKDW-----------EGVKDEIMYEVCLAKFQQ--------------------------HQDIQLTLIET------NDAKLVEHTTN--------DSYWGDGGDG---------------------------------SGRNQLGITLMRVRETIRN  147  330846708  eukaryota>amoebozoa>mycetozoa>dictyosteliida   
DDB_G0283925_Ddis_66810169           5    EHVINFYRPN-----EIPYGPFSNFSR----HTVFYNN---------------VLAKTSEHIFQAMK---F-----------------EGTQHFNDVLNT------KTPGDSAKMGRDRK-------------------RPLRKDW-----------EGVKDELMYEICLAKFSQ--------------------------HKDIQKILLET------GDATLVEHTGN--------DSYWGDGGDG---------------------------------SGRNQLGKTLMRVRETIKN  150  66810169   eukaryota>amoebozoa>mycetozoa>dictyosteliida   
FP2309_Fpsy_150026339                10   MNIIKFYKVN------EPYGFFSNFSP----HPIYINN---------------ERWNSVEHYFQASK---F-----------------DNIEIREKIQAI------ESPMQVAIEGRDKK-------------------NIIRDDW-----------EMVKEEIMYSALLCKFYQ--------------------------HPKLMKELLLT------KDSLIIEHTKN--------DNYWGDGGDG---------------------------------KGKNRLGLLLMKVREEIAK  154  150026339  bacteria                                       
PaecuDRAFT_4172_Pcur_304407843       1    MTQIKFYETN------KPYGCFSNFSK----HPIELNN---------------KRWATVEHYFQAMK---F-----------------ENTSFEEEIRLL------RTPMEAAIAGRDRN-------------------KPLRKDW-----------EEMKEIIMRRAIEAKCEQ--------------------------HESVRDILVST------GNCLLIEHTKN--------DSYWADGGDG---------------------------------SGQNKLGQLLMEVRSEQPE  145  304407843  bacteria>firmicutes                            
XNC1_2895_Xnem_300723771             4    IDVIKFYRTN------DPYGCFSNFSK----YGFLGEDD--------------FFWPTVEHYFQAKK---F-----------------IDENTQENIRLL------NSPMDAATAGRDRK-------------------KPLRPDW-----------EVIKDDIMRFAVLEKFKQ--------------------------NLDIQNILLST------HNAQLIEHTSN--------DFYWADGGDG---------------------------------SGNNMLGIILMETREILQK  149  300723771  bacteria>proteobacteria>gammaproteobacteria    
ybiA_Rden_311112847                  5    MTEIKFYRVN------DAYGYLSNFAP----YPFEING---------------LIWSTSEHYFQAQK---F-----------------LDKAIQEKIRRL------KSPMDAALEGRNRE-------------------NPLRSDW-----------EVVKDDIMRLAVFEKFRQ--------------------------NPAIRRELLAT------GHATLIEHTKN--------DNYWADNGDG---------------------------------TGKNMLGIILMETRKRLKA  149  311112847  bacteria>actinobacteria                        
ybiA_Spar_296876279                  1    MKEIKFYKVH------DEYGFMSNFAP----YPFSDGS---------------KIWPTSEHYFQAQK---F-----------------LVPEIQEKIRQI------ASPMDAALEGRNRQ-------------------NPLRSDW-----------EEVKDEVMHQALRMKFRQ--------------------------NPDIAKELLAT------GDAIIIEHTQN--------DAYWADGGDG---------------------------------SGNNKLGLLLMHVRQELKN  145  296876279  bacteria>firmicutes                            
ybiA_Ssan_325693558                  1    MKEIKFYKVN------DAYGYMSNFAP----YPFSDGN---------------KIWPTSEHYFQAQK---F-----------------LVPEIQEKIRLL------ESPMDAALEGRNRH-------------------NPLRKDW-----------EDVKDDIMRYAVREKFRQ--------------------------NTVIMEDLLET------GDSIIIEHTKN--------DSYWADGGDG---------------------------------TGKNMLGKILMEVRAELR-  144  325693558  bacteria>firmicutes                            
CORMATOL_00583_Cmat_225020576        1    MNEIRFYRAH------DDYGFLSNFAA----YPFELDG---------------KRWPTSEHYFQAMK---F-----------------LNPETQNLIRSL------DTPGRAAKVGR-RE-------------------KPLRKDW-----------ESVKDQVMFDAVLAKFTQ--------------------------NPDIARKLLST------GDAYLIEHTKN--------DFYWADGSDG---------------------------------SGKNRLGEVLMAVRDSLRA  144  225020576  bacteria>actinobacteria                        
Deima_1776_Dmar_320334379            1    MKAIRFYRQG------DAYGTFSNFSA----HPIHVDG---------------VTWPTTEHYFQAQK---F-----------------LDPELQAMIRAL------PTAGDAAKTGRRRD-------------------LPLRADW-----------EAVKEDVMRTALHAKFTQ--------------------------HEDARTLLLST------GDASLIEHTRN--------DTYWADGGDG---------------------------------HGLNRLGLLLMDLRAALRH  145  320334379  bacteria>deinococci                            
AM1_2731_Amar_158335874              1    -MTIFFYKVQ------DPYGCFSNFSL----HSIDLQG---------------QTWPTSEHYYQAQK---YQGT--------------PHQALCDKIRQA------STPEAAAALGRNPL-------------------YTEQADW-----------DVIKPEIMYAAVRTKFLT--------------------------HPTIQAELLST------GDELIVENSPL--------DPYWGCGADG---------------------------------KGQNQLGKILMQVRQEIRQ  147  158335874  bacteria>cyanobacteria                         
MC7420_6514_Mcht_254412559           1    -MTIYFYKVE------EPYGCFSNFSP----HPIQIDG---------------WCWQTVEHYYQAHK---FVGT--------------TDEALIRTIKNV------STPMEAALLGRDRT-------------------RNHRPDW-----------EQVKQQIMWRGVLTKFLT--------------------------HPDIQQILLNT------GEDVIVEDSPT--------DYYWGCGEDQ---------------------------------TGENHLGKMLMNVRQHIRQ  147  254412559  bacteria>cyanobacteria                         
all5029_Ana_17232521                 1    -MTIYFYKVW------QPYGCFSNFSP----HSIEIQG---------------TYWLTVEHYYQAQK---FVGS--------------VDAAIIPAIRAS------KTPEEAAALGRCTS-------------------RQLRQDW-----------DLVKTIVMREAVLKKFLT--------------------------HTDIREILLST------GNEILVEDSSC--------DYFWGCGADK---------------------------------TGQNHLGKILMSVREEIRK  147  17232521   bacteria>cyanobacteria                         
N9414_00365_Nspu_119509756           1    -MTIYFYKVW------QPYGCFSNFSP----HGIQIHG---------------TYWSTVEHYYQAQK---FVGT--------------VDAVIIPVIHAA------ETPEEAAALGRCRT-------------------RQLRPDW-----------EMVKTKVMREAVLNKFLS--------------------------HLEIKDILLST------GNETLVENSPN--------DYFWGCGAEK---------------------------------TGQNHLGKILMGVRAEIRK  147  119509756  bacteria>cyanobacteria                         
CRD_01664_Rbro_282897552             1    -MTIYFYKVW------EPYGCFSNFSP----HPIEIHG---------------VYWATVEHYYQAQK---FVHT--------------EDNVIIPLIRSA------PTPEMAAALGRCET-------------------RKSRPDW-----------NLIKIDVMKTAVWQKFLS--------------------------HQEIQEVLLGT------GDETLVENSPI--------DYFWGCGADK---------------------------------TGENHLGKILMGIRNQIRF  147  282897552  bacteria>cyanobacteria                         
OSCI_3190004_Osp._300866977          1    -MTIYFYKVE------EPYGCFSNFSP----HSIYLNG---------------QDWLTVEHYYQAQK---FVGS--------------VDEQLIYLIHAS------ETPQQAAKLGREPS-------------------RQLRPDW-----------EEVKTEIMREAVLTKFIT--------------------------HSDIQAILLST------GDRLIVEDSPT--------DYYWGCGCDR---------------------------------TGQNHLGKILMSVRLEISQ  147  300866977  bacteria>cyanobacteria                         
SYNPCC7002_A1948_Syn_170078553       7    -EPIYFYKAH------DPYGCFSNFSL----HPIHCEA---------------LDWPTVEHFYQAHK---FLPT--------------HQQDLIDKIRAA------STPEIAAALGRDPQ-------------------HPKRPDW-----------EDIKRTVMWQGVWTKFKT--------------------------HPDIAQILLAT------GDAAIIENSPV--------DYYWGCGADG---------------------------------SGRNYLGKVLMRVRSQLRQ  153  170078553  bacteria>cyanobacteria                         
tlr2465_Telo_22300007                1    -MTIYFYRVK------DAYGSFSNFSP----HGFTLEG---------------YYWPTAEHYYQAHK---FFGT--------------PYEAFGHAIRIA------PTPEAAAQLGRSGR-------------------YPVHPQW-----------DQLKQAVMWRALVAKFTT--------------------------HAELRELLLAT------VDEELVEDSPV--------DSYWGCGGDR---------------------------------QGSNYLGRLLMHLRHCLRQ  147  22300007   bacteria>cyanobacteria                         
Cyan7425_0270_Csp._220905714         1    -MVIYFYKVE------GPYGCFSNFSP----HGFELEG---------------QRWQTVEHYYQAHK---FVGT--------------PDHHLCTQIQQC------QTPAQAAALGRNPC-------------------HCPRSDW-----------EEIKQQVMRTAVLAKFKT--------------------------HPQIRTILLET------GEAWLVEDSPV--------DFYWGCGADR---------------------------------SGQNHLGRILMSVRQELRS  147  220905714  bacteria>cyanobacteria                         
_Krac_298249651                      1    -MTIYFYTAR-----EEPYGCFSNFSR----HGIDLDG---------------AWWPTVEHYFQAQK---F-----------------AGTPYANKIRIA------FTPKQAADLGRSRQ-------------------HPLRPDW-----------EQVKDEIMLKAVRRKFEL--------------------------HTQLRKLLLAT------GSEELIENAPS--------DYYWGCGSDG---------------------------------SGQNKLGQLLMRVRLELSS  145  298249651  bacteria>chloroflexi                           
Tery_2448_Tery_113476072             1    -MTIYFFDET-----EQPYGCFSNFSP----HGFELDG---------------LWWPTSEHYFQAQK---F-----------------LGVQHLEEIRWA------KTPAGAAKMGRERS-------------------RPLRKDW-----------EEIKEDVMERGLLCKFQS--------------------------HKDIGEILLST------KDELIVENAPE--------DYYWGCGKDG---------------------------------SGKNRLGEILMKVRNRLQN  145  113476072  bacteria>cyanobacteria                         
Cyan7822_3925_Csp._307153746         1    -MAIYFYSTR-----EQPYGCFSNFSQ----HGFELEG---------------FWWPTSEHYFQAQK---F-----------------PNHPWQDQIRKA------KTPKDAAKMGRDRR-------------------YPLRSDW-----------EEIKDEIMKRAVWQKFTT--------------------------HADIREILLQT------GDELIVENSPI--------DYYWGCGADG---------------------------------TGKNRLGEILMAVREILRA  145  307153746  bacteria>cyanobacteria                         
L8106_12950_Lsp._119486659           1    -MTIYFYSSR-----EEQYGCFSNFSY----HGFVLDE---------------LWWPTNEHYFQAQK---FVS---------------TDPEWFTKIQTA------KTPAQSARMGRSRE-------------------HPLRSDW-----------EEVKDEIMQKVVLCKFQT--------------------------HADIREILLST------GDEFIVENSPI--------DYYWGCGQDG---------------------------------SGKNKLGEILMAVREILRQ  147  119486659  bacteria>cyanobacteria                         
MC7420_678_Mcht_254413191            24   -MPVYFYSTR-----EKPYGCFSNFSR----HGFELDG---------------CWWATSEHYFQAQK---FVE---------------TDHPWFDKIREV------KTPKDAAKMGRSRE-------------------HPIRSDW-----------EQVKDEIMKRGVLQKFET--------------------------HADIREILLAT------GDELIVENSPS--------DYYWGCGKDG---------------------------------SGKNRLGEILMAVREILCQ  170  254413191  bacteria>cyanobacteria                         
ybiA_Osp._300869472                  1    -MTIYFYSTR-----EEPYGCFSNFSA----HGFELEG---------------VYWLTSEHYFQAQK---F-----------------VGTPHVEQIRQV------KTPKDAAKMGRERK-------------------RPLRQDW-----------EEVKDDIMRKAVLCKFET--------------------------HANIREVLLST------GDEEIVENSPI--------DYYWGCGKDG---------------------------------SGKNKLGLILMEVREILRQ  145  300869472  bacteria>cyanobacteria                         
Haur_0354_Haur_159896886             1    -MTIYFYAVS------AEFGCFSNFSA----HGFKLDG---------------HYWPTSEHYFQAQK---F-----------------TGTDYATTIRLA------KSPAIAARLGRSRK-------------------QPLRRDW-----------EAIKDAVMRRALLAKFRS--------------------------HAEIRAILLAT------DDQPLVENAPN--------DYYWGCGIDG---------------------------------SGKNMLGQLLVEIRQTLRD  144  159896886  bacteria>chloroflexi                           
AM1_3712_Amar_158336844              1    -MAIYFYSSR-----EKPYGCFSNFSA----HGLTLDG---------------VWWPTSEHYFQAQK---F-----------------VGTPHADQIRQV------KLPKDAARLGRQRT-------------------RPLRPDW-----------EAVKDDVMRQAVLCKFET--------------------------HADIQDILLST------GNQDLVENAPG--------DYYWGCGQNG---------------------------------TGKNMLGKILMEVRERLRA  145  158336844  bacteria>cyanobacteria                         
PM8797T_29763_Pmar_149176205         1    -MTIYFYTK------NDTYGEFSNFSP----HGVERDG---------------LWWPTVEHYFQAQK---F-----------------AEADYRERIRNA------HNAKQAANLGRSRK-------------------IPLRADW-----------EEVKDEIMYQGVLQKFQT--------------------------HAELKILLLST------GDQEIVENAPG--------DYYWGCGKEG---------------------------------TGLNRLGEILVRVRGELRE  144  149176205  bacteria>planctomycetes                        
TM1040_1897_Rsp._99081738            6    PDTIYFYAQ------TDPYAEFSNFAP----YGVCFED---------------IWWPTVEHYFQAMK---F-----------------HDAAYRTRIRRC------QKPKDAKALGMTRK-------------------IPLRADW-----------EEVKDDIMYAAVLCKFRT--------------------------HGAPRQLLLGT------GDAPLVENAPM--------DAYWGCGPDG---------------------------------LGLNKLGRILMRVRGELAE  150  99081738   bacteria>proteobacteria>alphaproteobacteria    
Jann_2797_Jsp._89055288              6    LNTIYFYAQ------TDAYAEFSNFAP----FGVEMEG---------------VYWRTVEHYFQAMK---F-----------------DDATHRERIRTA------RKPKDAKASGMTRA-------------------VALRADW-----------DEVKDAIMQAAVFRKFQT--------------------------HAVPRDLLLGT------GSAQIVENAPM--------DAYWGCGPDG---------------------------------RGLNKLGRILMDVRDSLAS  150  89055288   bacteria>proteobacteria>alphaproteobacteria    
SCH4B_1850_Sisp_259416444            5    PEPIYFYAQ------TDPYAEFSNFAP----YGVAFEG---------------TWWRTVEHYFQAMK---F-----------------HDADHRERIRRC------HKPKAAKALGMTRA-------------------IPLRADW-----------EEVKDGIMLTAVRCKFQT--------------------------HAAPRQLLLST------GDAPLIENAPM--------DAYWGCGPDG---------------------------------RGLNKLGQILMTVRSKLSG  149  259416444  bacteria>proteobacteria>alphaproteobacteria    
Sde_0405_Sdeg_90020054               9    EKALSFSR-------FDASHWLSPCVL----RPFQLDG---------------HTWPTAEHYLQANL---V-----------------ASAALADKIRQA------ASGEQAHALGSPWY-------------------RRKRKDW-----------KNLRRVLMTRALYTQTMT--------------------------HPDIKDALLET------GDQHIVETSLY--------DHYWGIARDQ---------------------------------RGENILGKVWMGVRDKIRA  152  90020054   bacteria>proteobacteria>gammaproteobacteria    
TERTU_3943_Ttur_254787804            9    ENAVRFSR-------FDPESLFSTVSA----HPLELEA---------------EVWPSAEHYFQAQL---A-----------------GSDSWREKIKAA------PTPAQAYKLGCVWY-------------------KRKVRGW-----------KNLRRVMMTRALYTKVQM--------------------------YPAVRDALLST------GDETILETSLY--------DHYWGIGRDQ---------------------------------RGDNMLGKVWMDIRRKLRE  152  254787804  bacteria>proteobacteria>gammaproteobacteria    
HP15_2779_Mbac_311695670             10   ENDLFMSR-------TDPENPLGTHAP----YSFELEG---------------KIWPTVEHYFQGMK---F-----------------TDDNRQEKVRSA------DTPGKAGKLGRKRH-------------------KSLRRDW-----------KQVRETVMTRGIYVRCRT--------------------------HPELAEALLDT------GDTKIVENSNF--------DYFWGCGRDR---------------------------------RGENRYGKVLMNVRARLRE  153  311695670  bacteria>proteobacteria>gammaproteobacteria    
RED65_02704_Bmar_94501287            9    EDAIFFSR-------LDEEEMLGSRIH----QPFLLDD---------------YNWPTAEHYTQALL---F-----------------KDAKIQQQIRES------EEPVEAAKQYKWRF-------------------WLKHKDW-----------KKRGPILMTRAIYTQCKT--------------------------YPVKAQALLDT------EDRLLMENSLY--------DYFWGCGRDR---------------------------------RGDNRYGKVMMSVRGRLRK  152  94501287   bacteria>proteobacteria>gammaproteobacteria    
GP2143_10137_Mgam_119476904          11   QDAMYFTR-------SDVNEDFGSFSK----HPFQLED---------------KEWPSVEHYYQAMK---F-----------------DDQAYQETIRCA------DHPKKARKLGRNRF-------------------RSIRKDW-----------RDVKVVYMTRAVYTMCRT--------------------------YPDIATKLLTT------GSNRLVENSQY--------DYFWGCGRDR---------------------------------RGDNHFGKVLMNVRDKLHT  154  119476904  bacteria>proteobacteria>gammaproteobacteria    
SCHCODRAFT_258660_Scom_302674850     60   RPQIFFYDR------DKPHYGFTNFSP----HPVKYKD---------------AIYPTSEHLFQAFK---FME---------------HQPQLAEHIRRQ------PRPRDALSEARRFD-------------------NEKRRDW-----------FKVNIDKMDEALHLKFTQ--------------------------HKDLQEELLST------GSAELIEDSPV--------DAFWGIGKDG---------------------------------RGRNELGKALGRLRKKLKR  206  302674850  eukaryota>fungi>basidiomycota                  
LACBIDRAFT_318005_Lbic_170095960     159  RPRILFYNK------SDPHYGFTNFSA----HSVVYKG---------------KRYPTSEHLFQSFK---FQK---------------HRPNLAEHIRTCS-----ERPSVAFSEARRFQ-------------------PEVRTDW-----------KQVNIEKMDEALWCKFTQ--------------------------HSDLKAELLST------GDAELVEDSDK--------DAFWGVGADR---------------------------------RGRNELGKALERLRAKLRE  306  170095960  eukaryota>fungi>basidiomycota                  
LACBIDRAFT_316770_Lbic_170117768     78   PSPIFFYHK------HDLHYGFTNFSD----HPVCYER---------------EMYPTSEHLFQSFK---FLP---------------HRPDLAKHIRSC------SCPSDALAKARRFK-------------------AYVRPDW-----------RRINIQIMDQVLLLKFTQ--------------------------HQDLKDELLAT------GNAELIEDSYK--------DSFWGVGADG---------------------------------QGRNELGKALMDLQDKLHR  224  170117768  eukaryota>fungi>basidiomycota                  
SCHCODRAFT_258659_Scom_302674848     103  AQRILFYHK------HDPHYGFTNFSD----HPVKYQG---------------KVYPTSEHLFQALK---FMP---------------HKSQVAEHIRTSS-----PSPRAAFTEAHRYQ-------------------SEVRKDW-----------SKVNVKMMEIALEHKFDQ--------------------------HPALREELLAT------GEAELVEDSAQ--------DAFWGVGPNG---------------------------------KGRNELGKALMRLRTQLRQ  250  302674848  eukaryota>fungi>basidiomycota                  
MGL_3049_Mglo_164657874              61   TNKIEFFSK------DLPFFWLNNASD----HPVVLDG---------------VRYPTAEHLFQAQK---FID---------------HRPDIANKIRKA------SNAVEAIHIARTFS-------------------RDVRADW---------IKDGVNVSTMRMVLLTKFMQ--------------------------YSDLRLALLET------GDAEIVHASPN--------DAFWGSAAAP-----------------------------NSVGRGRNMLGRTIMQTRE-LLR  212  164657874  eukaryota>fungi>basidiomycota                  
SCHCODRAFT_36431_Scom_302693411      1    --QIRFCNR------DTSYNSFCNFAR----YSVAYNG---------------ETYPTAEHLFHASK---FLP---------------VNGDIARRIRNT------KDVGEVARLADRFQ-------------------ARVPQEW-----------WNNMVETMHGILLDKFLQ--------------------------HEDLQAALLST------GDAELVFDSVE--------DGFWGVDKDE---------------------------------TGNNILGRTLERVREELR-  144  302693411  eukaryota>fungi>basidiomycota                  
HMPREF9488_03196_Csp._319937960      7    KIIDSFHG---------EYAFLSNYYD----SPIFYDG---------------ILYPTVEHAFQAAK---T-----------------TVFIQRIIIANK------KTPGQAKCAGRKV---------------------TLRDNW-----------DDIKLYIMKELIILKF-T--------------------------NPKLKSALLNT------KDAELIERNTWN-------DTYWGICN-G---------------------------------IGENHLGKILMEVREMLRG  145  319937960  bacteria>firmicutes                            
mru_1967_Mrum_288561223              3    DEIDRFDG---------KYLFLSNFYI----CDVEYDG---------------ILYPHTEAAFHAQK---V-----------------FDDETKMKFTNV-------TPKQSKRLGRKV---------------------KLREDW-----------NEVKDNIMYEVCKAKFEQ--------------------------NPDIRKLLLET------GDATLIEGNTWN-------DQYWGVCR-G---------------------------------KGRNQLGKTLMRIREELRE  141  288561223  archaea>euryarchaeota                          
DORFOR_01894_Dfor_166032191          27   TQINEFRG---------DYAFLSNFYP----APVSYMG---------------QTYANNEAAFQAQK---T-----------------LSAREQRKFCIFRM----HNPSDAKKLGRDL---------------------TLRPDW-----------EKVKVRLMYEICMCKFMQ--------------------------NPELRDKLLAT------GESTLIEGNNWG-------DYFWGKVN-N---------------------------------CGENQLGIILMDVRAKLQW  168  166032191  bacteria>firmicutes                            
RUMGNA_01423_Rgna_154503599          12   QTIDHFHG---------AYAFLSNFYP----SRIYYRG---------------YWYANNEAAFQAQK---T-----------------ISPKEQLQFTKL------RNPKDAKKLGREV---------------------QLRSDW-----------ESVKLMYMYEICMCKFMQ--------------------------NPTLCKALLAT------GNCHLVEGNNWG-------DYFWGSVN-G---------------------------------HGENHLGKILMDIRAKLQF  151  154503599  bacteria>firmicutes                            
CCU_25310_Csp._295094771             3    TTINSFRG---------DYFFLSNFYE----CPVTYQG---------------ITYPNNETAFQAQK---C-----------------INDSDKTKFISL-------NPSAAKKLGRRV---------------------ALRKDW-----------ESIKFSVMKNLVKAKFTQ--------------------------NPDLAEKLLAT------DNAHLEEGNTWG-------DRIWGTVN-G---------------------------------TGANKLGIILMQVRDELNL  141  295094771  bacteria>firmicutes                            
Rumal_1634_Ralb_317056301            1    -MIDRFTD---------EYFFLSNFYE----SKVTFEG---------------ITYLNNEAAFQAMK---T-----------------LDESERRSFAGL-------DPDSAKRAGRKV---------------------SLRSDW-----------EEVKTDLMYEICKAKFTQ--------------------------NKDLAEKLLAT------GGEELVEGNDWN-------DRIWGKVN-G---------------------------------QGENRLGIIFMKVREELRL  138  317056301  bacteria>firmicutes                            
nadE_Ralb_325680741                  1    -MIDSFKG---------DYCFLSNFYE----AKVTYEG---------------ITYLNNEAAFQSIK---T-----------------TDMAKRRDFADL-------DPAEAKKAGRNV---------------------SLRGDW-----------EDIKINVMYKICKAKFTQ--------------------------NSDIAEKLLAT------GDEELVEGNDHG-------DKIWGKVN-G---------------------------------EGANNLGKILMRVREELKM  138  325680741  bacteria>firmicutes                            
99_BPphiW-14_282599036               1    -MIDNFKT--------PETEWLSNMYP----CRVLYEG---------------VVYPSAEHAYAAQK---A-----------------VDWLDREEIAQA------KTGYLAKQMGAAV---------------------QKRADW-----------DQVKMRVMLEVLRAKFFN--------------------------NDFLGDKLLAT------GSQELVEGNWWH-------DTFWGVCE-G---------------------------------VGENHLGKLLMQVRRELEA  140  282599036  dsdna viruses, no rna stage>caudovirales       
Pmar_PMAR024558_Pmar_294875527       18   NVIRAFRG---------EFGFLSNFSD----DPVRMDDG--------------ILYPTAEHAFQAQK---V-----------------VDVEKRRCMVEKC-----GTAKSAKAWGKRAK--------------------PLRADW-----------NDIRVDVMREVIGAKFKGG-------------------------SEELREMLVAT------GERELVEGNVWN-------DTFWGVSLRT--------------------------------GKGQNQLGKILMEVREELKK  163  294875527  eukaryota>alveolata                            
_BP1_308516893                       13   KPIMGFQG---------EYRWLSNFWT----APIVVTG---------------FEYQNTEAAYQAAK---T-----------------INVAHRMQFKNM-------TGGEAKRAGRSV---------------------IMRHDW-----------DFVKLEIMELVLRAKFMA--------------------------HADLALKLIET------GDRDIVELNTWG-------DTHWGQIKDK-----------------------------EGNLVGENVLGKLLMNIRSDINK  156  308516893  dsdna viruses, no rna stage>caudovirales       
Mpe_B0288_Mpet_124262828             3    AAPISFYRAS-----ERPFGAFSNLFR----REILIAG---------------RTFATTEHAYQALK---P-----------------RDARVRDWLLAA------PAPSLLAIAAHTLPSESADPTEIMARTADALLGFHTRPGW-----------SRLRFPWMLRCLDAKFDQ--------------------------HPDLAELLLST------GDSAIIEAGRIDDDA----GRRWGIVN-G---------------------------------RGSNYLGRMLQRVRHRLGG  170  124262828  bacteria>proteobacteria>betaproteobacteria     
bgla_2p0770_Bgla_330822167           19   LNEIRFYRAN-----EKPYGAFSNLYK----RPIEFEG---------------VTYPTSEHAYQAGK---A-----------------VKPAVRQWILSA------PTPALAAMAAHGLY------------------VWDVVPDW-----------AQIKFDRMRAVLRAKFDQ--------------------------HADLRELLLST------GEARLVEAGTVNNAV----NRLWGEVD-G---------------------------------KGENMLGVMLMELRAAYAK  168  330822167  bacteria>proteobacteria>betaproteobacteria     
PSPA7_3050_Paer_152987782            1    MQEIRFYRAN-----EKPYGAFSNLYK----REVLFEG---------------VVYPTSEHAYQAGK---P-----------------RKEAVRDWILSA------PSPALVAMAAHGLY------------------WWDIRPGW-----------SKIKFDRMRAILLAKFTQ--------------------------HEDLKALLLST------EQARLVESATVDNEV----NRTWGEVN-G---------------------------------KGKNMLGVLLMEVREELLH  150  152987782  bacteria>proteobacteria>gammaproteobacteria    
Tgr7_1771_Tsp._220934941             20   KESAVFYKTK------ETFGALSNMAS---GYPLRVNC---------------VRILTSEALYQACR---FP----------------HLPEVQRVIIDQ------KSPIAAKMKSKPHR-------------------KDSRPDW-----------DQVRVGVMRWCLRVKLAQ-------------------------NYKEFGRWLLVT------KDKEIVEQSKK--------DAFWGAKVID---------------------------DDGEILVGQNVLGRLLMELRELYRN  173  220934941  bacteria>proteobacteria>gammaproteobacteria    
GSTUM_00011304001_Tmel_296424705     50   TGPVYFWKPH-----EVPFGIFSQWYE----DEFTAPFDGEQ-----------MRFGTAEQYMMYSKAVLF-----------------NDPDTAAEIMKT------MNPSTQRALGRKVR-------------------NFTDVTW-----------AENRSRIVEEGSYWKFKK--------------------------DP---SRLLET------GDREMVEASPR--------DRIWGIGFGP----------------------KNADAGKRDKW-GMNLLGKALMEARDRLRR  209  296424705  eukaryota>fungi>ascomycota                     
R617_APMV_311978014                  4    DKYVFFHGAN---KNQAGVHIFSQWFP----VNFKEYLNGEE----------FAEYVSAEQYMMAHKALLF-----------------GDMFHFKKIMEC------SKQCKIKYLGRRVR-------------------NFNPTIW-----------DKHKFDIVTEGNRLKFSQ--------------------------NPDLMKRLLET------GNKTIVEASPS--------DKIWGIGLTA----------------------QQAVNIPENKWPGKNLLGKVLMKIREEN--  168  311978014  dsdna viruses, no rna stage                    
Esi_0071_0113_ESV_298714411          57   EGMVLFWK---------EPACFVQWTP----CSFELDG---------------ERYCNAEQWMMASKARLF-----------------NDRTALQQIMAT------ADPRRQKALGRQVR-------------------GFDPAMW-----------DKKGYDVVVRGNLAKFKQ--------------------------NPGFRDELLAT------GDRILAEASPY--------DSEWGIGLHA----------------------NDADALIQARWPGRNKLGEALMDVRSQL--  210  298714411  eukaryota>stramenopiles                        
Esi_0017_0056_ESV_298707265          134  DTMVLFWN---------PPCVFTQWEP----ALFEVDG---------------VKYCSAEQYMMACKANVF-----------------GDTDIWNKIMST------SDPAQQKRLGKEVA-------------------NYDHGIW-----------NLCKVQFVLTGNYSKFTQ--------------------------NPGMCDQLLAT------GDKMLAEASQH--------DKVWGIGMDA----------------------FDPNVERHECWRGQNLLGKILMYVRNKI--  287  298707265  eukaryota>stramenopiles                        
Esi_0345_0025_ESV_298711392          58   PDLLFFWQ---------PPSVFSQWTP----SVFVVDN---------------VQYSCAEQYMMAEKAKLF-----------------GDNSSWQKIMAT------PSPREHKDLGRGVS-------------------GYDQNVW-----------DQHKMRIVARGNYAKFTQ--------------------------NEMMGQRLLDT------GEKLLAEASPY--------DRVWGIGLRA----------------------DNPAARTPSSWRGQNLLGDILQEVRTR---  210  298711392  eukaryota>stramenopiles                        
NAEGRDRAFT_31328_Ngru_290996009      18   QKYEFFWK---------DKSVFSNWHA----ASYVLDG---------------IQFANTEQGMMYGKAKLF-----------------GDDEVAKDILAN------TSPSNAKQLGRMVS-------------------NFTDDMW-----------NQNRELIMKRHLYAKFSQ--------------------------NEDIKQTLLST------GDKILAEASPN--------DAIWGIGMRE----------------------HEAIETHPSKWPGLNLLGKLLTEVKQELRN  173  290996009  eukaryota>heterolobosea                        
NAEGRDRAFT_36485_Ngru_290990814      20   SKFHFFWG--------TKGGYYSQWVK----APMKIDG---------------KTFVTCEQYMMYQKAQLF-----------------NDHEMAEKILKT------SDPKQCKEFGRKVK-------------------NFDTNQW-----------EANRDRIVYEGNYAKFTQ--------------------------NEEMRRDLLSR------LDVEYVEASPY--------DKIWGIGLEE----------------------KDQRAHDRSQWKGLNLLGRIITQIRDDLIN  176  290990814  eukaryota>heterolobosea                        
NAEGRDRAFT_31151_Ngru_290996214      26   SKFFFFWN---------EETCFSQWVK----APMKVND---------------QTFSNCEQFMMYQKALLF-----------------NDQEIAKRILQS------TNPKNTKALGRKVS-------------------NFNEKIW-----------EDNKVRIVYEGNYAKFAQ--------------------------NDDLRKDLLSR------PDVEYVEASPY--------DKIWGIGLEE----------------------KDPRAKQRNEWQGQNLLGRIITQVRDDLMM  181  290996214  eukaryota>heterolobosea                        
PRU_0345_Prum_294673111              5    DKHICFWN-----------EWPSNWHP----AEFDVEVNGV-----------KCHFYNTEQYFMYMKAIVF-----------------GDEEIAKQILEV------SDPKKVKALGRKVQ-------------------NYDEAVW-----------NEKRYQVMLKANVAKFSQ--------------------------NEDLKQLLLSPEY----EGHGFVEASPY--------DKVWGVRMFE----------------------SNPDIDDETKWKGLNLLGKVLDETRRIVSL  164  294673111  bacteria                                       
Fisuc_1361_Fsuc_261415758            7    DKHVFFYH-----------EWLSNFWN----APFEYKG---------------RTFFCNEQAFMWEKAVLF-----------------GDKVMEEKILVA------STPQEAKRLGRKVT-------------------PFDKEKW-----------DSVRYQVMLDINYAKYSQ--------------------------VEDCKNRLLDPEF----DGHAFVEASPR--------DRIWGIGLSV----------------------TNPNIDDPANWRGRNLLGKVITEVRDRLVQ  162  261415758  bacteria                                       
KgORF4_BPK_48696395                  5    REYIMFWG---------KEDIYSNFYP----IKFKHQG---------------RTFNNSEQAFMWRKARYF-----------------NDFQIAGEILNA------KNPNHAKSLGRKVR-------------------NFNEEQW-----------NKVRYNIMVEVVKDKFMT--------------------------THLKQRILDTD------VRKDFVEASPY--------DKIWGVGLKA----------------------NDPKILEQSNWKGQNLLGKVMEDVRVHCIY  160  48696395   dsdna viruses, no rna stage>caudovirales       
bgla_4p0890_Bgla_330814539           5    GNFTAFFG---------AEDVLSNWHP----SRFTYHD---------------VEFNCVEQFMMYAKAMLF-----------------DDHGTASKILTA------QSPKRQKELGRDVS-------------------GFDEQTW-----------IKSRESIVFVGCREKFRQ--------------------------NPSQGTVLSGT------GSTILVEASRS--------DKIWGAGIGQ----------------------FDSRITDPTKWPGLNLLGYTLMRVRDRPFS  160  330814539  bacteria>proteobacteria>betaproteobacteria     
bgla_3p0420_Bgla_330818849           5    NNMTLFFG---------AEDALSNWHQ----CRFEYHG---------------VAFTCVEQFMMYAKAKLF-----------------EDHATAAAILAT------TDPHKQKQLGREVK-------------------GFNDAVW-----------VEKREAIVTVGCREKFQQ--------------------------NPALRDTLLAT------GDTVLVEASPY--------DRIWGVGFAW----------------------NDPLILDPKNWRGTNLLGKTLTTVRQLLKD  160  330818849  bacteria>proteobacteria>betaproteobacteria     
Rpic12D_5003_Rpic_241589866          5    LGMTLFFG---------AEDALSNWHP----ARFTYRG---------------VEFSSVEQFMMYSKARLF-----------------NDDQTARKILSA------SEPREQKRLGREVR-------------------GFDEAVW-----------IIKRKPIVTVGCREKFWQ--------------------------NQPLGEVLLGT------DDTLLVEASPY--------DRIYGVGLAW----------------------NDPRIRDVSQWQGLNLLGEVLMEVRTWLPK  160  241589866  bacteria>proteobacteria>betaproteobacteria     
GobsU_010100015693_Gobs_168700969    3    ETFTFFWK-----------HRLSQWHR----APFVICG---------------VTFTHAEQYMMYAKALLF-----------------GDRETAGKLLAA------ETPREQQALGRAVR-------------------GFDESVW-----------VLFREGIVFAGNYARFGQ--------------------------NPDQRELLFST------RGTTLVEASPH--------DRVWGIGLSA----------------------DDPRARDRSRWLGLNLLGATLTRVREALLF  156  168700969  bacteria>planctomycetes                        
M23134_00353_Mmar_124010457          5    EQFTFFWE---------TRSPLSQWHP----SDFTVDG---------------VAFNCAEQYMMYQKAKLF-----------------EDEQIAAQILRT------KKPRDQKALGRKVR-------------------NFDATTW-----------NNHCKKIVYDANYAKFTQ--------------------------NETLKASLLAT------TGTTLVEASPY--------DKIWGIGLAV----------------------DHPDVQDKSKWQGTNWLGEVLTQLRDDLIS  160  124010457  bacteria                                       
PPE_02438_Ppol_308069201             2    EKFTFFYR---------SHSPFSQWYP----SDFVADG---------------LEFNCAEQYMMLKKAQLF-----------------GDEEAALKIMQV------PTPREQKARGRSVR-------------------GFDQSLW-----------EGNCRQFVYDGNYAKFTQ--------------------------NPNLLKYLLKT------KGTTLVEASPT--------DTIWGVGLAE----------------------SDARIRNRKLWRGTNWLGEILTNLREDVLQ  157  308069201  bacteria>firmicutes                            
AceceDRAFT_2244_Acel_303240378       2    EKFTFFWR---------SHSPFSQWYI----AKFIING---------------IEFNCAEQYMMYMKAVLF-----------------KDEEISQKILEA------KMPSQHKSLGRKVK-------------------HFNQEVW-----------ESNCKKIVYDGNYAKFTQ--------------------------NPELKQKLLET------KG-TIVEASPV--------DSIWGVGLSE----------------------DDPRIQDRKTWRGKNWLGEVLTQLRDDLLK  156  303240378  bacteria>firmicutes                            
Sterm_3136_Ster_269121732            2    EKFEFFWK---------SDSPFSQWYK----KGFKVKG---------------KSFNCAEQYMMYMKAVLF-----------------GDEIIAAKILEA------KSPREQKDLGRKVK-------------------NFNKDIW-----------ERQCKNIVYNGNYAKFTQ--------------------------NEGLKSALLET------KGKTLVEASPY--------DTIWGIGLSE----------------------ENPDSKRRSKWRGKNYLGEILTQLREDILK  157  269121732  bacteria>fusobacteria                          
MXAN_5330_Mxan_108762267             7    QRFTFFWQ---------AHSPFSQWHP----SDFTVDG---------------VRYVCAEQYMMAGKARLF-----------------GDNEALASILSS------KSPKTHKALGRKVR-------------------DFDNTRW-----------EKARERIVYEGNRAKFTQ--------------------------SPELLKALLAT------AGTELVEASPV--------DRIWGVGLDE----------------------EDPRILHPAKWRGLNLLGKVLTKLREDLLA  162  108762267  bacteria>proteobacteria>deltaproteobacteria    
Bresu_2709_Bsub_302383816            19   EGFHPFIK-----------GVFSQWHP----TPFAIDG---------------LSFHTAEQWMMFAKARLF-----------------ADDQQADLILAT------PDPATQKRLGQRVQ-------------------NFDQATW-----------DASKINIVYAGNRAKFEQ--------------------------NEGAYRQLKST------SGLMLVEANPR--------DWIWGAGLAI----------------------DDPCLSQPQEWRGVNLLGRILTKVRSDLS-  171  302383816  bacteria>proteobacteria>alphaproteobacteria    
C08E8.4_Cele_212646224               12   QTYVLFYE---------DESVFSNFHP----SNFEAETAKKLVNSGMFKEEEMLKFNCSEQYFMYHKALLV-----------------GDVDSAKVIITA------KHPMVMKMTGRQLN-----------------MNRHDIDNW-----------TQKSRDIMYLACLAKFSQ--------------------------NVELRKMLFRT------QDMYLVEASGN--------DAIWGNGIWK----------------------EDKRSDDVANWHGTNYLGEILDRIRGELIG  184  212646224  eukaryota>metazoa>nematoda                     
T24A6.7_Cele_17564644                13   KQFVFFYK---------FDCVFSNFYP----CEFSAQEFENDVEKN-------VNFNCSEQYFMYHKALLV-----------------GDSEIAGKILKE------TDPRKMKRLGRQLS-----------------MSKKQLEEW-----------SQNSKEVMYNGCLEKFSQ--------------------------NNVCRENLFRT------HGMRLVEASPM--------DRIWGIGLSH----------------------HDKRCENEQTWRGTNWMGSVLDKVREELWT  178  17564644   eukaryota>metazoa>nematoda                     
LOC588539_Spur_72168255              9    DRYTFFYG--------EKSAPFSQFRA----ANFEVDG---------------VQYTCAEMYMMHQKAVLF-----------------GDHEIAEQILLG------TKPMAMKALGRKVR-------------------NFDEEVW-----------KQNRRQIVKKGNLAKFSQ--------------------------NPDIRAELMAT------RGTTLVEASPR--------DKIWGIGMGK----------------------DNPHAKNKSKWRGQNLLGYILTEVREELEK  165  72168255   eukaryota>metazoa>echinodermata                
DR_1263_Drad_15806282                68   TEYLFFYR---------TAHPFSNFHP----SPFSASG---------------RQFHTAEQYIMHRKAEEF-----------------GDHASAKAILQA------RTPAECKALGRRVQ-------------------GFSESHW-----------AQVRGQVAFDAAWHKFRS--------------------------SRRLREFLLDT------GELILVEAAPN--------DRIWGIGYSE-----------------------QDAWEHRDQW-GENLLGQALMQVRERLRD  221  15806282   bacteria>deinococci                            
Pc16g08100_Pchr_255940726            25   VDTIFFWKI------NSDFGEFSQWYR----SDFVCDD---------------EAFATAEQYMMYKKAMMF-----------------GDSNMSERILCS----SSADPRKHKSMGRKVA-------------------NFNEVIW-----------ESRNMNVAINGNYCKFAQ--------------------------NIDLMKLLLGT------GDKMIVEASPM--------DRIWGIGFDS-----------------------KLAMSNVGRW-GQNRLGKSLMTVRSMIKD  183  255940726  eukaryota>fungi>ascomycota                     
FG02760.1_Gzea_46111757              7    PGPVYFWKES-----DPEAGYLSQWYY----CPFRDDK--------DER----IRYKTAEHYMMFQKAMLF-----------------KDEHTAIEVLKA------ATPRKVKALGRKVK-------------------NFNEATW-----------LKHRCDIVRHGNILKFTRAISEKGYKKGSPSG---------NPLEGSLLDTLLRT------GDRELVEASPF--------DPVWGIGFKA-----------------------ADAEAARGSW-GENLLGKELMAVRSILRK  184  46111757   eukaryota>fungi>ascomycota                     
NECHADRAFT_29138_Nhae_302884348      5    SNPLYFWRET-----DPVSGYLSQWYY----CPFRDDG--------DEK----KTYKTAEHYMMHHKALLF-----------------NDEKVALQILRA------GHPREVKSLGRKVS-------------------NFDEATW-----------NAHRREIVRRGNLLKFTNAVSEEGFQKGTPAKGKSAVKRKYEPIEGSLREMLLST------GEREIVEASPF--------DRIWGIGFKA-----------------------ADAEAARESW-GQNLLGLELMEVRRILRE  191  302884348  eukaryota>fungi>ascomycota                     
PMAA_059590_Pmar_212541268           10   DNPVYFWKP------EGDYGFLGQWWP----SSFSWKT-------DDEE----YTYASAEQYMMHRKALLFAG---------------PEDPITLQIQTG----WKLRPSVIRDLGRQIP-------------------NFSEEAW-----------QQNRYEIVLEGNYLKFSQ--------------------------NEELKEKLLET------GARELVEASPR--------DRIWGIGFGA-----------------------RHAGANRREW-GLNLLGKVLMETRERLVR  174  212541268  eukaryota>fungi>ascomycota                     
TSTA_012120_Tsti_242799239           9    SNPVYFWRP------EGEYGFLGQWWP----SSFSWKN-------GDEE----FTYANAEQHMMHRKALLFAG---------------PSHPITHQLQKA----WKLEPGTIRDLGRQIP-------------------DFSEQMW-----------QQNRYAIVLEGNYLKFSQ--------------------------NGDLRRELLAT------EDRELVEASPR--------DRIWGVGFGA-----------------------AYASENRREW-GLNLLGKALMETRERLRR  173  242799239  eukaryota>fungi>ascomycota                     
MGYG_00619_Agyp_315054313            3    SEPIFFWKP------EQEHGYLGQWWK----SDFTVPA-----EDGGKE----LKYENCEHYMMHQKGVLFA----------------PDDPVTQEILAPSG--PVPDPKTIKALGRKVP-------------------NFDDAVW-----------KKERFRIVVQGNYYKFTQ--------------------------NPELKAQLLET------GDRELVEASPR--------DRIWGVGFGA-----------------------KNAPAKRANW-GLNLLGKALMEVRERIRR  170  315054313  eukaryota>fungi>ascomycota                     
HCAG_05480_Acap_154278399            6    SEPVYFWKP------ESENGYLGQWYT----SDFTWAR-NAADAHGDVEI---VKYDNAEQFMMHRKGLLFA----------------PDDPITQEILARDS--PSPHPRDLRSLGRQIP-------------------NFDDAVW-----------KTHRYAIVVEGNYLKFTQ--------------------------NPQLKEELLAT------GDRELVEASPR--------DRIWGVGFGA-----------------------KNAGARRKHW-GLNLLGKALMEVRERIRK  178  154278399  eukaryota>fungi>ascomycota                     
LACBIDRAFT_252516_Lbic_170107053     5    DDYVFFWKT------NEKYGWASQWYS----SPFTVKL-KL-EEEGEEEE---VTFASAEHWMMVQKALLF-----------------GDYGKAREILGVEG-VSSSDMAHVKALGRQVS-------------------GFDEAKW-----------VDARQDIVLQGNMHKFSQ--------------------------NGELLEKLMLT------GDKKMVEASPR--------DRIWGIGFGE-----------------------KNALNQRERW-GLNLLGIALEGTRRKLNK  176  170107053  eukaryota>fungi>basidiomycota                  
PTRG_08392_Ptri_189204778            24   TKPVFFWKP---------NSYLSQWYW----SKFTVDG---------------DTYATAEMWMMVQKARLF-----------------NDEKTAKQMLAT------TKPHEHKALGRQVK-------------------GFEARVW-----------DQHKVQIVTQGNYHKFTIS-----------------------TDAENLRKMLLAM------GERELVEASPV--------DRIWGIGFAE----------------------REAERM-RHKW-GQNLLGKALVKVRGSLRA  180  189204778  eukaryota>fungi>ascomycota                     
GCWU000342_00580_Ssat_229828516      1    MTVIGFHNP------DEKYGFLSNWYL----SHFTVHG---------------TEFSSVEQYMMYQKAACF-----------------YDEDIASQIMKT------DDVAEIKQLGRAVN-------------------GYDDHVW-----------NGIRQIVVYEGLMAKFSQ--------------------------NQELKEQLMDT------GGAILAECAVR--------DRIWGIGLSM----------------------TDPDRFDRSKWKGQNLLGYALMMVRDRL--  157  229828516  bacteria>firmicutes                            
RflaF_010100008155_Rfla_268609453    14   MNVICFHNP------DEENGYLSNWYL----SDFTVDG---------------VKFTSMEQYMMYRKAMCF-----------------HDSDIAAQILET------SDVEQIKALGRLVR-------------------NYDDHHW-----------NGVRQIVIYEGLKAKFSQ--------------------------NPDLLKMLKDT------GDALIAECAVK--------DRIWGIGLSM----------------------TDPDRFDRTKWNGQNLLGYALMMVRNILTV  172  268609453  bacteria>firmicutes                            
HOLDEFILI_02959_Hfil_223985602       2    MKIVCFHNP------DEENGYLSNWYP----SRFIVKN---------------RVFSSMEQFMMVRKAVCF-----------------HDDSAAAQILAT------EDVARIKELGRHVS-------------------NYDDHHW-----------NGIRQIVVYEGLLAKFSQ--------------------------NEDLKEQLKAT------GDAVLAECAVK--------DRIWGIGLSM----------------------SDPDRMNREKWQGQNLLGYALMMVREQL--  158  223985602  bacteria>firmicutes                            
GCWU000341_01684_Osp._291459520      1    MNVIGFHNP------EEENGFLSNWYL----SAFRSDN---------------IDFSSLEQFMMYRKAVCF-----------------RDDESAARILST------DDTAKIKALGRLVS-------------------GYDGHIW-----------NGIRQLVVYEGLLAKFSQ--------------------------NESLKRDLLDT------GDALLAECAVK--------DCIWGIGLSM----------------------TDPKRFDPSQWRGQNLLGYTLMMTRSKLAA  159  291459520  bacteria>firmicutes                            
_Bado_154487137                      2    TDIICFHNP------DEENGYLSNWYP----SRFVVVD---------------VEFSSMEQYMMYRKACCF-----------------NDAETAARILRT------SDVAEIKRLGRLVA-------------------GYDDHVW-----------NGVRQIEVYEGLLAKFSQ--------------------------NAELGAQLVAT------GNAILAECAVK--------DRIWGIGLSM----------------------HDPARLDPAQWRGQNLLGYALMLTRKKLNR  160  154487137  bacteria>actinobacteria                        
ROSINTL182_08410_Rint_240146453      1    MDILCFHNP------DEENGYLSNWYM----SQFDVNG---------------IGFSSMEQYMMYKKAVCF-----------------RDDVIAEKILET------DEVGSIKELGRMVA-------------------GYNENYW-----------NGIRQIVVYEGLIAKFSQ--------------------------NDKLREGLLHT------KDQILAECAVK--------DRIWGIGLSM----------------------KDPDRMDLSKWRGQNLLGYTLMMIRDRL--  157  240146453  bacteria>firmicutes                            
M23134_07250_Mmar_124009340          129  DEKFYFFSS--------SDSPFSTLYK----AKFIIQG---------------ITYNSVIQYIAHHKARLF-----------------LDRGIEKGILKS------DSQKEIYQLSLQVK-------------------NYDKVTW----------HNMYLGQHISFAYQQQFLQ--------------------------NEYLKDVLFST------EGKTIVLSDKN--------DEKWGIGLSQ----------------------LNSKALQRNTWLGKNFLGEILTRLRIELMG  286  124009340  bacteria                                       
PSPA7_5219_Paer_152985284            16   FKYLYFWGHRPAADDQVGKSCFSQWYE----ASFKLGG---------------VRYASAEHYMMAAKARLF-----------------DDRKLLERILAA------RSPGEAKALGREVA-------------------GFDEALW-----------SAERMGIVIEGNLGKFGQ--------------------------NASLKKYLLGT------ADRVLVEASPV--------DAIWGIGLAA----------------------TDPQATEPAAWRGLNLLGFALMEVRRRLAQ  180  152985284  bacteria>proteobacteria>gammaproteobacteria    
MDS_1227_Pmen_330502141              20   FDYLYFWGHSRAAGAPVGKSCLSQWYP----SAFTLDG---------------IHYATAEHFMMAGKARLF-----------------DDAEALERILAA------RAPNEVKAIGRQIR-------------------GFDEARW-----------RESRQAIVFEGNLGKFSQ--------------------------DPELARYLLDT------APRVLVEASPV--------DPVWGIGLAE----------------------GDSNVRTPATWRGLNLLGFALMQVRECLLN  184  330502141  bacteria>proteobacteria>gammaproteobacteria    
_Kora_238022350                      20   LKYVYFWGHTPKQKGIADEAVFSQWYP----APFELDG---------------ERYATAEHYMMAEKARLF-----------------GADDIRCQILQA------GSPAQAKALGRQII-------------------GFQDDIW-----------NAHRFDIVCRANHAKFSQ--------------------------HPDLKTFLLQT------GERILVEASPV--------DSIWGHRLGA---------------------RRPPRRKPVAMARLEPARLRADESARPIAGS  188  238022350  bacteria>proteobacteria>betaproteobacteria     
BBR47_45420_Bbre_226314127           19   VKYLFFWGHTQKDSGTTDKSCFSQWYP----AAFVEDG---------------ITYLTAEHYMMAKKAELF-----------------GDLAIRDEILRK------NHPKQAKDLGRKVH-------------------SFDEAVW-----------NANKTAIVRQANLLKFSQ--------------------------HADLKAYLLDT------GDRIIVEASPY--------DRIWGIGMAQ----------------------DHPHAEQPEKWRGENLLGFALMAVREQLRS  183  226314127  bacteria>firmicutes                            
ABSDF2913_Abau_169634335             21   FKYLYFWGHIPKKANLIDKSCFSQWFP----AQFNVEG---------------IEYFTAEHYMMAQKAKLF-----------------NDKEIFAQILQV------KHPNEAKQLGRKVR-------------------NYDEQIW-----------REKRFDIVVQANFAKFSQ--------------------------HPELKKFLLAT------KDRILVEASPV--------DKIWGVGMAQ----------------------DHPHIQDPSLWQGLNLLGFALIHVRELLLT  185  169634335  bacteria>proteobacteria>gammaproteobacteria    
HMPREF0012_02967_Acal_262281016      20   FKYLYFWGHTPKQVDLIDKSSFSQWYP----VQFKDEG---------------IEYLTAEHYMMAQKAKLF-----------------NDEGIFAQILQV------KHPNEAKQLGRKVR-------------------NYDEKIW-----------QEKRFDIVVQANFVKFSQ--------------------------HPELKNFLLAT------KDHILVEASPV--------DKIWGIGMAQ----------------------DHLHTQDPSQWQGLNLLGFALMHVRDQLLA  184  262281016  bacteria>proteobacteria>gammaproteobacteria    
LMHCC_1724_Lmon_217965001            18   LKYIFFWGHQPAEDGKISKSCFSQWWI----CSFKVDG---------------VEYNCAEQFMMAEKAKLF-----------------NDMEMREKILAA------KHPKQAKDFGRLIS-------------------GFQEDIW-----------LKNRFNIVMRANQAKFSQ--------------------------NEELKKFLMQT------KNRILVEASPV--------DKIWGIGMAT----------------------DNKNVENPLYWKGLNLLGFALMVVRDELEN  182  217965001  bacteria>firmicutes                            
PROPEN_00827_Ppen_226326967          16   IKYIYFWGHQ-SKGNDITKSCFSQWYP----APFILDD---------------VRYASAEHYMMAEKAKLF-----------------NDIDVRKRIITA------SNPGSAKALGREVK-------------------GFDQDIW-----------EQHRMDIVIRANIAKFSQ--------------------------NKELGNFLIST------GNRVLVEASPV--------DKIWGVGLSE----------------------QDNEINNPLLWKGLNLLGFALMKVRSILIE  179  226326967  bacteria>proteobacteria>gammaproteobacteria    
EHI_017590_Ehis_67472915             30   HQYTYFWKP--SIEEEVNKSCLGNWYP----SEFDYDG---------------IHYYFCEQFLMGCKAKLF-----------------GDDQIFKLILDS------RNPYEMKKLGKKVK-------------------GFNQEVW-----------DEYKAAVMFEGGLAKFTQ--------------------------NPQLRRFLMET------GDDILVEASKF--------DAVWGIKMEE----------------------SDERANDPHQWCGENILGFTLMSIRDYLLV  192  67472915   eukaryota>amoebozoa>entamoebidae               
CCC13826_2022_Ccon_157165319         106  DKFLLFWGHQKSA--NLSASCLSQWFN----SIFWQDE---------------TKYICAEQYMMAKKALCF-----------------GDKEALKQILSA------KDPAQMKGLGRQVR-------------------GFDAKVW-----------DEVKFGVVLNASYLKFSQ--------------------------NAPLRDFLLQT------GSKILVEASPV--------DKIWGIGLGA----------------------SDENAQNPMKWRGQNLLGFALMRARDEIAK  268  157165319  bacteria>proteobacteria>epsilonproteobacteria  
ANACOL_01151_Acol_167769817          19   CRFLFFWGHTPPADGHVNESCLSQWWM----CRFSAGG---------------VEYNCAEQYMMAEKARIF-----------------GDNEMLEKIMAS------KFPKEMKAYGRAVR-------------------NFDQAVW-----------DSRCYDRVLTGNLAKFGQ--------------------------NADLWEFLAGT------KGHILVEASPR--------DRIWGIGMGK----------------------QNPNAPNPTLWRGKNLLGFALTEAR-ELLQ  182  167769817  bacteria>firmicutes                            
GYMC10_6272_Psp._261410041           18   FKYVFFWGHTPPKDGSVDKSCFSQWWM----CPFTVEG---------------TEYSCAEQFMMAEKARLF-----------------GDNEMLESILTA------KHPKEMKAYGRAVR-------------------NFDKDTW-----------DKECYGIVKRASLAKFSQ--------------------------NPELGDYLKST------KNRILVEASPR--------DRIWGIGMGQ----------------------SNPDAENPVKWRGRNLLGFALTEARDELLQ  182  261410041  bacteria>firmicutes                            
HMPREF1977_0666_Coch_315224011       151  LKFLFFWKPNAD---AIDESCFSQWQL----SPFNVNA---------------NEYSCTEQYMMAEKARLF-----------------DDEEVEKEIMNT------TDPKLIKALGRKVR-------------------NFDPAVW-----------DKVKYSIVLNGNYYKFTQ--------------------------NQAMMDFLLST------GDKILVEASPL--------DTIWGIGLGK----------------------DNEKAFNIASWRGKNLLGFALMEVRDELRK  312  315224011  bacteria                                       
HMPREF9071_1307_Csp._326335654       113  LKFVFFWKPNCK---VVDESCFSQWQP----SSFCIDG---------------DEYSCTEQYMMAEKARLF-----------------GDKEVEEEIMNT------SDPKLMKALGRKVR-------------------NFDPQVW-----------DKAKYSIVLNGNYYKFTQ--------------------------NKEMMDFLLST------GDKILVEASPM--------DTIWGIGLSK----------------------DNEKSQNIAAWRGKNLLGFALMEVRDEIRK  274  326335654  bacteria                                       
Cbei_3546_Cbei_150018370             104  LEYIYFWGHHPKKDGGITKSCFSQWWK----SRFNIGH---------------TEYLFMEQYMMAEKARFF-----------------GDKEIEEKIMNS------YDPKEIKIFGRKVR-------------------GFDEEIW-----------NRAKYSIVINGNYNKFMQ--------------------------NERLKTFLLST------GDKILVEASPY--------DNVWGIQMSE----------------------EDVNIKNPELWRGENLLGFALMEVRNEIKR  268  150018370  bacteria>firmicutes                            
_Fpra_160945914                      125  RELCLFWGHQPAKDGQLTKSCLSQWWT----EDFWFVA---------------NTYLCMEQYMMAGKAELF-----------------GDQEIREQILKC------SDPKQIKALGRKVR-------------------GFDQKVW-----------DKFKYAIVLNGNWCKFSQ--------------------------NRDLREFLLST------GDSVLVEASPY--------DNIWGIRLSA----------------------NSPEAQDPMKWRGQNLLGFALMEIRDELRR  289  160945914  bacteria>firmicutes                            
LMHCC_1997_Lmon_217965272            94   YNFNQMKNENQPELYLFENCYFSHCWM----EEFSVST---------------QKYCCMEQFMIEQKAELF-----------------NDTTTKQKVLET------NSLEQIQALDKEVQ-------------------SFDQDIW-----------DKFKYAIALYGNWNKFNQ--------------------------KRILRDYLLST------GYSILVETNPS----------------------------------------GSPNMPNPLKRHGQNLLGLALMELRDELRR  248  217965272  bacteria>firmicutes                            
BHWA1_00589_Bhyo_225619532           82   IDFLFFYGHT-NDKKEVTKSSLSQWYI----KDFRDND---------------LVFNCMEKYMMYNKALLF-----------------DDKDIANEILNN------NQPKAIKELGRKVK-------------------NFNDEIW-----------DKMKYKIVFTGNYYKFSQ--------------------------NTDLRNFLIST------KNKVLVEASPY--------DKVWGIKMKY----------------------DDENIENPFYWKGENLLGFALMEVRDEIKR  245  225619532  bacteria>spirochaetes                          
Bmur_0365_Bmur_296125416             85   IDFLFFYGHS-NDKKEINKSSLSQWYI----KDFREND---------------LTFNCMEKYMMYNKALLF-----------------DDKNIADEILNT------NQPKAIKELGRKVK-------------------NFNDNIW-----------NNMKYKIVFIGNYYKFSQ--------------------------NTDLRNFLLST------KNKVLAEASPY--------DKVWGIKMKY----------------------DDENIENPFCWKGENLLGFALMQVRDEIKR  248  296125416  bacteria>spirochaetes                          
CPR_0151_Cper_110802054              18   LEFLFFWGHTKNKNGKITKACFSQWYL----SDFTVNG---------------VLYNCAEKYMMAEKARLF-----------------KDYETLEEILSA------ENQKEIKDLGRKIK-------------------NFNEELW-----------NREKYEIVKRGNLAKFSQ--------------------------NENLKEFLLNT------GDKIIVEASPY--------DSIWGIGMGA----------------------KDENIEDPTAWKGENLLGFALMEVRDLLNK  182  110802054  bacteria>firmicutes                            
FSDG_00336_Fsp._237744336            18   LKFLFFWGHTENG-AETTKACFSQWYS----CKFVVDE---------------IIYHTAEQYMMAQKTLLF-----------------NDNEIFHKIMSS------KSPKEYKELGRKIK-------------------NFSDSKW-----------NENKYQIVLKGNIAKFSQ--------------------------NEKLKVFLLNT------DTKILVEASPY--------DKIWGIGLSA----------------------DQENIKNPLTWNGENLLGFALMEVRDLLNK  181  237744336  bacteria>fusobacteria                          
AceceDRAFT_0731_Acel_303238852       110  IKYLFFWGHQPSVDGSITKTCFSQWWK----SDFTIDI---------------EDYCCMEQYMMAEKARLF-----------------EDKEILEEIMKS------KHPKQIKELGRKVR-------------------NFDEEVW-----------KKKRYSIILNGNYAKFLQ--------------------------NEELRQFLIQT------QNRVLVEASPY--------DKIWGIGMSA----------------------DDEHIENPLEWQGLNLLGFALMEVRDELIR  274  303238852  bacteria>firmicutes                            
Fjoh_0750_Fjoh_146298513             12   SKFLFFWGHQPSKDGTITKNCFSQWWL----SSFKVNE---------------VTYKTAEHWMMAKKAELF-----------------NDQEILEKIIQC------NSPAEAKKLGRKVK-------------------NYDDKIW-----------LENRFEIVKEGNYHKFSQ--------------------------NSDLKTFLLNT------NDRVIVEASPV--------DPIWGIGMAG----------------------DHKDALNPEKWKGLNLLGFALMEVRDELR-  175  146298513  bacteria                                       
KAOT1_16128_Kalg_163754439           29   LKFLFFWGHQPSKDGSITKSCFSQWWE----DAFTVNN---------------EIYKTAEHWMMAEKARIF-----------------NNSEIRKEILMA------SHPHDAKKLGRKVK-------------------NFDPIIW-----------DEHKFNVVVEGNYHKFSQ--------------------------HEDLKQFLLNT------KNRILVEASPR--------DRIWGIGMSE----------------------KNEKATNPNLWRGQNLLGFALMEVRDHLKK  193  163754439  bacteria                                       
Cpin_0074_Cpin_256419128             18   LNFTFFWGHK-GEPGNVTKSCFSQWWP----SAFTDGT---------------HTYATAEHWMMAGKARLF-----------------KDPAMEQEILQT------SDPATAKKLGRKVA-------------------NFDTALW-----------DVEKFSLVVQGNLLKFSQ--------------------------YPKMKEFLLST------GDSIIVEASPL--------DRIWGIGMGA----------------------NHEHAANPLLWKGQNLLGYALMEVRDQLKQ  181  256419128  bacteria                                       
HMPREF0204_10236_Cgle_300774513      18   IKFLFFWGHT--TKDTITKSCFSQWFP----GKFEENG---------------TIYKTAEHYMMAGKARLF-----------------NDPETEEKILKA------NTSNQAKALGRKVK-------------------NFDPKQW-----------DEHKFEIVTRGNLLKFSQ--------------------------NQKFKDFLLST------GDKVLVEASPY--------DRIWGIGMLD----------------------TDSRAENPLLWNGENLLGFALMEVRDELRG  180  300774513  bacteria                                       
EcSMS35_3361_Ecol_170684265          21   VKYLWFWGHQPAANHEITASCFSQWWQ---GSPFTYDG---------------ITYATAEHWMMAGKARLF-----------------NDSKTLARILAA------ATPAEAKKLGRQVT-------------------NFDEQCW-----------QACCFDLVCEGNYHKFSQ--------------------------HSALKTFLLNT------QPRILVEASPV--------DKIWGIGLAK----------------------DHPHAGVPSHWKGKNLLGFALMVVRDRLA-  185  170684265  bacteria>proteobacteria>gammaproteobacteria    
CIT292_10857_Cyou_283836396          21   FDYLFFWGHRPSSSGAITASCFSQWWP----SPFEVDG---------------ITYASAEHWMMAEKARLF-----------------GDESTLLRILSA------KSPAEAKAFGRQVS-------------------GFNQQVW-----------EENCFESVCKGNVHKFSQ--------------------------HPELGEFLIST------RTLVLVEASPV--------DRVWGIGLAQ----------------------DDERAGDPLRWNGSNLLGFALMVVRDRIAN  185  283836396  bacteria>proteobacteria>gammaproteobacteria    
Slin_1821_Slin_284036735             18   IKYLFFWGHQKSKSGDLTASCFSQWWT----SPFIIDK---------------VKYNTAEHWMMAQKALLF-----------------GDKEVYDKIIVA------KSPAEAKSLGRQVR-------------------NFDEATW-----------SAKRSGIVVQGSLQKFTQ--------------------------HPDLKEFLLNT------KERVLAEASPV--------DKIWGIGLAA----------------------DSDKAENPKRWNGLNLLGFALMEVRDILRK  182  284036735  bacteria                                       
Ndas_4523_Ndas_297563442             23   AEYLCFWGHQPPASGGVSASCLSQWWP----ADFTVEG---------------VGYRTAEHYMMAAKARLF-----------------GDAEAEERILAA------GHPRDAKVIGRQVR-------------------GFDEREW-----------EAARFGIVVEGGLGKFGQ--------------------------NPELREFLLGT------GGRVLVEASPR--------DRVWGIGLGA----------------------ENDDARVPERWRGLNLLGFALMETRARLAA  187  297563442  bacteria>actinobacteria                        
AMED_1633_Amed_300783556             23   PEYLLFYGHTPSKSGRVTASCLSQWWV----DPFEADG---------------VEYPTAEHYMMAGKAALF-----------------GDHEKAELIRTT------PDPKAAKVLGREVA-------------------GFDAAIW-----------ERHRFDIVVDGNLAKFRA--------------------------HRDLRRFLLGT------GDAVLVEASKK--------DLVWGTGLAR----------------------EEKNATKPDYWRGLNLLGFALMEVRDQLRA  187  300783556  bacteria>actinobacteria                        
Caci_2927_Caci_256392113             28   PKWRLFFGHRARIPGVVDEACLSQWWP----AEFRIGS---------------ITYFTAEHWMMVSKAQLF-----------------GDSDAWARVLST------RDPAVAKRAGRNAC-------------------DFDETTW-----------AAVRFGLVVAGNYAKFAQ--------------------------NSDLRAFLAGT------AGEVLVEASPY--------DRVWGVGLAA----------------------SHRDVRDPAAWPGLNLLGFALMRVREELMA  192  256392113  bacteria>actinobacteria                        
Plim_2199_Plim_296122446             17   IEFLYFWGHTPPENGEVNHACLSQWYP----SPFTIDG---------------VVYPTAEHWMMASKARLF-----------------GDFATLAEIRAT------ISPKEAKAAGRKVR-------------------DFDEARW-----------EAHRFRFVVDGNWAKFTQ--------------------------NHTLRQYLLGT------GTKVLIEASPT--------DHIWGIGLSE----------------------QEARNSSPEHWPGLNLLGFALMEVREQISE  181  296122446  bacteria>planctomycetes                        
Kfla_1718_Kfla_284029681             20   YKYVFFWGDTPSADGQADASCLSQWYR----APFTVGE---------------VRYPTAEHWMMAAKARLF-----------------GDRDAERDVLAA------GHPQQAKAIGRTVR-------------------GFDTEVW-----------QQHRFDLVVEGNVRKFEQ--------------------------NPVLRDYLLGT------GERVLVEASPV--------DRIWGIGLAA----------------------DDERAEHPDQWRGLNLLGFALMQVRDQLTT  184  284029681  bacteria>actinobacteria                        
SSGG_05341_Sros_291448123            25   VKYLPFWGHRPRPDGRIGASCLSQWWP----SPFTVDG---------------VTYASAEHWMMAGKARLF-----------------DDPEAEAAAVTA------KSPAAAKKAGRLVR-------------------GFDEDVW-----------IGERFALVVAGSVHKFGQ--------------------------DPELAGYLLGT------GDRVLVEASPR--------DRIWGIGLAA----------------------DDERAERPQEWRGLNLLGFALMEARERLRA  189  291448123  bacteria>actinobacteria                        
SGM_1884_Sgri_329936685              21   VKYLYFWGHQERPGGRLGASCLSQWWP----SPFIVDG---------------VEYATAEHWMMAGKARLF-----------------GDADAERLALAA------PHPAQAKKAGRQVR-------------------GFDEAVW-----------RRERFRIVVEGSVHKFGA--------------------------DEELREFLLGT------GERVLVEASPL--------DRVWGIGLAA----------------------DDEAAGDPERWRGDNELGFALMVARERLRE  185  329936685  bacteria>actinobacteria                        
SSRG_01621_Sgri_302558106            33   VRYLHFWGHRPGPDGRVGASCLSQWWP----SPFTVDG---------------VEYATAEHWMMAAKARLF-----------------ADPEGERRVLAA------EHPAQAKKAGRLVR-------------------GFDEAIW-----------RRERFGVVVEGSVHKFAA--------------------------HDDLRAFLLGT------GDRVLVEASPV--------DQVWGIGLAA----------------------HDEGAADPERWRGPNLLGFALMEARARLRA  197  302558106  bacteria>actinobacteria                        
KSE_25370_Kset_311895942             113  PKYLCFWGHRPQRDGQIGPGALSQWWP----SPFTVDG---------------VRYDTAEHWMMAGKARLF-----------------GNEEIVPRILGA------RTPAEAKNLGRLVT-------------------GFDEDRW-----------VEHRFELVVTGSTAKFGQ--------------------------DERLRTYLLRT------GERVLVEASPL--------DRIWGIGLAA----------------------DDQRANSPAQWQGSNLLGFALMEARARLAG  277  311895942  bacteria>actinobacteria                        
_Ctes_221067792                      23   PKYLCFWGHQAERNGSVGKGCLSQWFS----APFTVEG---------------DRFATAEHFMMAGKARLF-----------------GDEEARAQVLAA------PSPASAKQIGRSVR-------------------NFDEARW-----------KAECFDIVVSANVAKFTQ--------------------------NPAMGEFLLRT------GERVLVEASPR--------DRIWGIGLGA----------------------THPDAEQPRKWHGQNLLGFALMAARTQLRA  187  221067792  bacteria>proteobacteria>betaproteobacteria     
PFL_5821_Pflu_70733106               86   PDCLMFWGHQPTRDGRISQSCFSQWFD----AGLELDG---------------IQYPSAEHFMMAGKALLF-----------------GDQETHGRILKA------VTPADVKQLGREVR-------------------GFDDARW-----------TEARLDIVVQGNLAKFSQ--------------------------HQALGEYLLST------GDQVLVEASPV--------DRIWGIGLAA----------------------EDARASRPEQWRGLNLLGYALMEVRDRLRI  250  70733106   bacteria>proteobacteria>gammaproteobacteria    
Daci_5761_Daci_160901192             23   PRFLPFWGHQPAADGSIGKTCMSQWFE----AGFEVEG---------------QHYPTAEHFMMAGKARLF-----------------GDEAAHAAIVRC------RTPGEAKKLGRGIQ-------------------GFDEAAW-----------VAARMDIVVRANEAKFSQ--------------------------NPALARYLLNT------GDRVLVEASPV--------DAIWGIGLAA----------------------DDVRATDPARWQGLNLLGFALMQVRARLRS  187  160901192  bacteria>proteobacteria>betaproteobacteria     
Amir_3505_Amir_256377585             7    MGHLFFWGHTPHRDGELGRECLSQWWE----RPFELDG---------------RVHPTAEHAMMTGKALLF-----------------GDERTAGRVAEA------RTPGEAKSLGRQVR-------------------GFDEDTW-----------ARERLELVARLNEAKFGQ--------------------------HDDLRAYLLGT------GGRVLVEASPV--------DRIWGIGLAA----------------------DDPRATDPDQWRGLNLLGEALMLARARLAA  171  256377585  bacteria>actinobacteria                        
Caci_5873_Caci_256395008             3    VKYLFFWGHTPNRPGTVGAECLSQWYP----APFEVDG---------------LRFATAEHSMMWGKAQLF-----------------GDEQAAARIVAA------GHPKEAKDLGRTIR-------------------KFDEDTW-----------VAERVAIVTAGNVEKFRQ--------------------------NPDLLAFLLTT------GERVLVEASPM--------DRIWGIGLAS----------------------DDERAQDPARWRGLNLLGEALMAARKTLRG  167  256395008  bacteria>actinobacteria                        
Sros_2401_Sros_271963927             26   LRYLFFWGHRPPRGGGVGAGCLSQWWE----VAFTVDG---------------HLFRSAEHYMMAHKAWLF-----------------GDGETAVRILAA------GHPGEAKKLGREVR-------------------GFDESVW-----------NEHRYEIVVGANIAKFGQ--------------------------HPELGDFLLGT------RGRVLVEASPV--------DRIWGIGLTA----------------------DDERAASPATWQGLNLLGFALMDARDALDT  190  271963927  bacteria>actinobacteria                        
FRAAL2340_Faln_111221771             24   LRFRYFWGQRQAVADGTGAGCLSLRWP----ARFAVDG---------------VDYPSAQHYVLARKAGLF-----------------GDQAAAEAVLAL------PAPISLAAVGRRIR-------------------GFDEAVW-----------DRHRYAVALAANSAKFAQ--------------------------NAILRTYLAGT------AGLVLADISPR--------DRVWGIGCDR----------------------DDDRAGRPSAWPGRNLLGFALMEVRDALLA  188  111221771  bacteria>actinobacteria                        
FrEUN1fDRAFT_4219_Fsp._288920206     31   LAFRYFWGHRRPAGGGIGPGCLSQWWA----VEFTVEG---------------RRYASAEHFMMERKARLF-----------------GDDETAEEILAA------PDPGRAKALGRRVR-------------------GYDDARW-----------ERHRHGVVVAGNTAKFGQ--------------------------HDDLRGYLLST------GSDILVEASPL--------DAIWGIGLAA----------------------SDERAGRPARWPGLNLLGFALMDVRAALAN  195  288920206  bacteria>actinobacteria                        
FraEuI1c_6936_Fsp._312200713         33   LSFRFFWGHRPPAGGGVGASCLSQWYP----SPFTAEG---------------QRYATAEHFMMAGKARLF-----------------GDDKTVDAILGA------PDPGRVKALGRRVA-------------------GFDEATW-----------ERHRYDIVVAGNLAKFGQ--------------------------HDRLRGFLLAT------GDDVLVEASPL--------DTVWGIGIAA----------------------GDPRAEHPIDWPGLNLLGFALMDVRAALRS  197  312200713  bacteria>actinobacteria                        
VAB18032_22000_Vmar_330468357        21   VKFLFFWGHQPQRDGSVGAGCLSQWWS----APFTIDG---------------LRFATAEHYMMWRKATLF-----------------DDHATAARVLAA------AHPHAAKMLGRQVT-------------------GFDQHVW-----------EQHRYDIVLTGTVAKFDE--------------------------HPALRTYLIGT------GERVLVEASPL--------DRIWGIGLAA----------------------DHPHATDPARWRGLNLLGFALMQARDILTG  185  330468357  bacteria>actinobacteria                        
Micau_3582_Maur_302868047            29   VKYLHFWGHRPRPDGSVGASCLSQWWP----AAFTVDG---------------REFATAEHWMMWHKATLF-----------------GDHAIAERVLAA------GHPHRAKALGRQVR-------------------DFDEATW-----------TARRYEIVVAGSVAKFGR--------------------------HEPLRRFLLGT------GDRVLVEASPT--------DRIWGIGLTA----------------------DDPRAADPATWRGDNLLGFALMEARATLAG  193  302868047  bacteria>actinobacteria                        
MCAG_03098_Msp._238062132            50   VKYLFFWGHRPQPDGSIGPGCLSQWWP----APFVVNE---------------VRYATAEHYMMVGKARLF-----------------GDEATAARMLTV------PSPGAVKALGRQVQ-------------------GFDQTVW-----------DAHRFDLVVAGNVAKFGQ--------------------------HPELRKYLART------GNRILAEASPV--------DRIWGIGLAA----------------------TDPRTCNPAQWRGLNLLGFALMHARAQLAT  214  238062132  bacteria>actinobacteria                        
NBCG_01909_Nbac_326330475            37   PRYVHFWGHTPKGPG-VGMHVLSQWWP----KVFADAD--------------GRSFASAEHYMMWRKAVLF-----------------GDDRTAARILDA------ASPGAAKALGREVS-------------------GFEDEVW-----------LEHRWRIVVEGSTLKFGS--------------------------DPALRDYLLAT------RGRVLVEASPR--------DRIWGIGLGK----------------------SSPYAEEPARWNGLNLLGFALMEARNRL--  199  326330475  bacteria>actinobacteria                        
EFP_gp169_BPphiEF24C_158079465       2    SKYILFWGHTPSKRNKLGKECLSQWYP----SQFTAPI---------EGLGEDIIFPTAEHYMMVRKAMLF-----------------NDVDTAKRILKT------ESPKDAKRLGRQVK-------------------NFEEDLW-----------VKHRKSIVLDGNTYKFTQ--------------------------NDSLRNFMLSIP-----KGTKFAEASPF--------DKVWGIGLRE----------------------SDPRSRDMSKWEGLNLLGEVLTEVRENLN-  172  158079465  dsdna viruses, no rna stage>caudovirales       
SS1G_05618_Sscl_156053544            46   LFELGFSR---------HTPFTSNPLC--------------------------KRTSTIFTYFQAVKAWVV-----------------KDRSKFMQIAHT------RSGLEAKKLGNAIK-------------------DLPVARW-----------DQISRHVMADALYFKFNH--------------------------NADIRNELIST------GSKVLIEARD---------DRVWASGIKT---------------------VKATAKTPISEWQGQNKLGEELMRLRHFFR-  193  156053544  eukaryota>fungi>ascomycota                     
GSTUM_00003347001_Tmel_296414614     4    NPPIYFREDDLRY----YPFCLSHTCTF--TSSPTGPG-------NTAPPGVCCYFTSLTQYLQYRKALFF-----------------YDHRAAEDILTT------SDVSLIMSISRRIN-------------------GLQVEVW-----------NGMRNTLVREGLMLKFGQ--------------------------NEELRRLLLDT------GDRELVYASG---------TRDWGVGFAP----------------------TDAGKS-RDSW-GLNLLGQALMDVRRRLRE  171  296414614  eukaryota>fungi>ascomycota                     
F44E2.8_Cele_32565136                54   DNVVYFNG---------PTHYLSALYP----CTVVVDG---------------NEYNSVEHYYQACKLYVL-----------------TGEQSAAQLKAS------ETPIEVKKATKNILKEAK-------------IPAKKISAW----------KDKDSIAVLKHVIYHKFNQ--------------------------NDELKVKLLDT------GDKILIQTYIG--------DTYFAAGANAKYTSTWVDRHVNQSLKYPENVVVDNVQYLPLVANGKNVLGWILMQVRDELRM  238  32565136   eukaryota>metazoa>nematoda                     
consensus/100%                       -    ....................................................................................................................................................................h.........................................................h......................................................................b.....
consensus/95%                        -    .....h...............hsph........h.....................h.s.-.hhb..+...h.........................h..........ps......s.............................W..................h......bh.p.............................h...L..o..........lhp............s..au.........................................s.hs..h...R..h..
consensus/90%                        -    .....F...............hoph........h.h...................a.s.E.hhb..K...h.........................l..........ps......up............................W..............p..hh..s...Ka.p..........................p..h...Lh.T..........lhc.s..........D.hWu.......................................G.N.LGb.L..hR..l..
consensus/85%                        -    .....F.............s.hSpa........h.hps.................a.ssEphhbh.K...F..................s......lb.........ps..h..hu+.........................p..W...........p..p..lh..s.b.KF.p..........................p..h...Lh.T.......s..llE.s..........D.hWG.s.....................................G.NbLGbhL..hR..l..
consensus/80%                        -    ...l.Fa............s.hSpa........h.hps.................a.ssEpahbh.K...F..................s......lb.s.......ps..h..hG+p........................p..W...........p..+..lh..u.b.KF.p..........................p..h.pbLl.T.......s..llE.ss.........D.hWG.u.....................................GbNbLGbhLhplRp.l..
consensus/75%                        -    ...lbFa............uhhSpa.......sh.hps.................asosEpahbh.K...F..................s.....pIb.s.......sP.ph..hGRp.p......................c..W...........p..+.plh.pu.b.KF.Q..........................p.plbpbLLsT......ss..llEsos.........D.hWG.G.s..................................pGbNbLGbhLMplRppL..
consensus/70%                        -    .p.lbFa..........s.uhhSpa.......sh.hcu.................asosEpahbu.K...F..................c.p..ppIb.s.......sP.phb.hGRp.p......................c..W...........pp.+.plhbpu.b.KFpQ..........................p.plbphLLsT......ss..LlEsos.........D.hWGhG.s..................................pGbNbLGbhLMplRppL..
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
#====== global.consesus                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
consensus/100%                       -    ....................................................................................................................................................................h.........................................................h............................................................................
consensus/95%                        -    .....h...............hs.h........h.......................s.c.hhb..+...h..........................................................................h.................hh.......h...................................l.............h.c............p.............................................s.h.............
consensus/90%                        -    .....h...............ho.h........h.......................s.E.hhb..K...h.........................h..........ps......sp............................a.................hh.......h.p..........................p..h...l.............h.-............c...s.........................................s.h.b.....p..h..
consensus/85%                        -    ...h.h...............hS.h........h..ps.................h.s.E.hhb..K...F.........................hb.........ps..h...s+............................a..............p..hh.......h.p..........................p..h...Lh............h.-.p..........c..hs.........................................s.h.bhhb..+..l..
consensus/80%                        -    ...l.h...............hS.a........h.hps.................h.ssEphhbs.K...F..................s......lb.........ps..h...s+............................a..............p..hh....b.bh.p..........................p..h.p.Lh.s..........lh-.s..........-..hs.......................................u.s.hsbhhhp.R..l..
consensus/75%                        -    ...l.h.............s.hSpa........h.hps.................a.osEphhbu.K...F..................s.....plb.s.......ss.phb..uR............................W...........p..+..lh..s.b.+h.p..........................p.pl.pbLl.T..........lh-.s..........D.hau.s.....................................GbNbLGbhlhphR..l..
consensus/70%                        -    .p.lbF.............s.hSpa.......sh.hpu.................a.osEphhbu.K...F..................s.....plb.s.......ss.phc.huRp.p......................b..W...........pp.+..lh..s.b.KFpp..........................p.plbpbLl.T.......s..ll-.ss.........D.hWGhs.....................................GbNbLGbhLhphRpbL..
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    Multiple Sequence Alignment of the BC4486 ART family 
    ALIGN           ---EEEEE----HHHHH-H----------------------HHHH-------------------EEEE--------------EEEEE-------------------EEEEEE--HHHH-----------EEE-----------------------HHH-HHHHHHHHHH-----------------------HHHHHHHHHHH-----HHHHHHHHH---------HHHHHHHHHH------------EEE------
HMM             -HHHHHHHHH--HHH-------H--HHHHHHH-----HHHHHH----------------------HHHHHHHHHH------H--EEE---EE--------------------E-----E-------EEEEE---------HH-------------------------EEE--------E---HH-------EHH---EEEEEE------EEEEEEE-----------------EEE--E----H----EEEEEE---
FREQ            --EEEEE-----HHHHH---------HHHH----------HHHHHHHH----------------EEEE------H-------HHHHH-------------------EEEEEE--HHHH----------EEE---------HHH-----------H-HH-HHHHHHHHHH-----------------------HHHHHHHHHH-------EEEEEEE-----------HHHHHHHHH-----------EEEE------
PSSM            ---EEEE----HHHHHH-H-----HHHHHH---------HHHHHHHH-----------------EEEEE---------------HHHHH-----------------EEEEEE-----------------EEE----------------------HHHH-HHH-----------------------------------EEEE----------EEEEEE---------HHHHHHHHHH-------E---EEEE------
FINAL           -EEEEEE----HHHHHH-H------HHHHHH--------HHHHHHHHH----------------EEEE---------------HHHHH------------------EEEEEE----------------EEEE-------HHHHH-----------HHH-HHHHHHHHHH-------------------------HHHEEEEE-------EEEEEEE-----------HHHHHHHHH-----------EEEEE-----
225620246       KLIYHLTAINNFESIIRN--GLCPRNKIKP----NIDVADNEILNGRNKY-N---------LLDYVPFHFFINTP-------FDGAVKKKY-----------KTTDFIYICLEREIAKM-------NEFKIIPCHPLSNRLINYENI---LFDYDKGF-DLIEWDKIDSDN-------------RNYVDQDIKNACMAECLYKGVISCRIFSSISVKD-----VESFKKIDKILLK----F-G------FISDKNKY
307823107       KLLYHLTSIKNIGPILAD--GLKPRAELKN----FDDVADSEIIVNRRHL-S---------LENFVPFHWFARNP-------FDGRVQADR-----------PNDLFVLITVERTLAVS-------RNWKVIPYHPLSAGNIEL-------MDYSKGF-AAIDWDTMNRR---------------DYHDPLCKSICMAECLSPITVSPDDFFNIFVYC-----DDSVSYVRRFDRQ--I-------KITKNERMFLP
104779561       RFLYHLTSVANVSSIFQR--GLLPRTVLDEE--EFADIADAEIILGRRQQ-G---------LEQYVPFHWFAKNP-------FDGRVYQDR-----------PDEEFVLIAVERSHAQT-------QNWSVIARHPLSGSRFEL-------LGYDEGF-EAIDWDLMDRR---------------DYHDQECKHVCMAECLAPGPVPVSQFAKIYTPS-----DEIFGYVRAQAVA--AGFRN---LWIDANRNMFP
269140414       QFLYHLTDLNNLEDIFSE--GLKSRSLLRG----FSDVADPEIIASRSAL-R---------LEEYVPFHFFARNP-------FDGRVHRNN-----------PNKTFVLITVRRSHAQT-------NSWSVIPRHPLSGSTITL-------LDYEAGM-ATIDWETMNRR---------------EYGDDNCKCVCMAECLSPTSVPASDFNSIFVPD-----AETEATVNNLKRT--YGL-N---MYVNNSPHMFP
299141966       RFLYHFTDKRNIPSIKRHG-GLFSWHYCET-----NNINIPRQGGDYDSR-ELD-KKYG--LQDYVRLSFCDDHP-------MKYRLQQ-------------SGSDMVVLRIKIDVALL-------KDTLFSDINAADRLHTH--------GGSLLDL-KRVNFDATKRH-------------FVSKNDEDFKP-HQAEVMVKTFVPLKYIVNI-------------------------------------------
268609383       NGFYNIMPISNLASVLKY--GILSNELAERI--PHRSVAMSIIQDRRDQV---LIPNGLM-LHQYANLYIDARNP-------MLYKRKD----------------EDVIVLKVDCRILD------LPDVVVSDQNASSSYVRFY--------EPEEAM-NKLDFNMIFAR--------SWESDNQ-FEYWRKKSAKCAEVLVPGKIEPSYVIAAAVK---------NDADKEKIIA--LGF-D---KRIYVNGDLFF
254410814       KYLYHMTAISNLRSILQH--GLLSHKEAHRLELVMMDISDPEVQRRRDDK--KDTIYSRL-LHDYVPLYFSPRNP-------MLYRRREI--------------QENIVILGIKPEVIF------KANTVFSDGNAASKGTIFY--------NDVAML-DSLCWNIINAL--------NW------SDFPEGKRIKCAEVLVYPKIDVKNIVSIFCYS-----GNQLSTIHETIRYF-RAIPLSLTISVQVKPELFF
302864537       QELHFITPISNLESVLRH--GILSHNAARRL--PHLSVADEDVQSRRRQK---RVPGGMQ-LHDYANLYFDARNP-------MMYRIKGN--------------GTPLAVVCVNPSILD------LPGVVITDGNAASDGTRFA--------ASPGGI-AILDEGLVYAH--------SWTSSDR-WDYIERKRARCAEVLVPNCVDPSYIDKAKVI---------RQSHVISCHA--AGL-R---GEVF--ANVFF
297618118       TELHYITHIENMKSIMRF--GLLSNRRASRT--RHNSVAMQVIQERRAGK---RVPGGLL-LHDYVNLYLCARNP-------MMYKLRGR--------------HKELCVLRIDVGVLN------IPGTIVTDRNASSDWACFY--------PSPVGL-KHVDLELVCAQ--------SWVHNDE-IETFKHKSIKCAEVLVPHHVPTSFFKGVYVSC----AESMSRLHCLAGDG--K-L-E---IEVY--PHMFF
315652379       TGIYNIQAIDNIPSIIRR--GLLSNERAVSI--KHKSIAMDEVQARRDNI---IIPNGLK-LHQYANLYFDPRNP-------MLFKRKSQ--------------NEEICILKFDRVILD------FNGVVLSDRNASSSYAAFY--------EAKYGL-ENIDFKLVYAR--------YWTDDNY-FEQCRRKSIKCAEVLVPYGISYDYVVFAAVV---------NDAAADRLRL--NGF-D---KNIFIEPKIFF
91215317        GGLFYITHLDNVASILKL--GILSHNLAHSNGFVSTDISNQQVNARRNRI---DPNLGGN-IHDYTPLYFNHKNP-------MLYTLCKN------------TDRNKLILLKVNPHILL------AENVSFSDGNASVRSTKFY--------NNIEEF-NNINWTLINSG--------SWNHYEF-NIKREQSRIMCSEVLAKEKIPSYYINEIFVYS-----EETLEQILPMFPN---HL-G---IKTSINKSLYF
163847525       KRLYHITHIDNLASILQY--GILSHRQVESQNVSFTPIYNENIVHNRKER---LTPDQRS-LWDYANLYFQPRNP-------MLYKVLSEK-----------STREIVILGVKPQVLDT-------KGAFIALGNAAHSQTEIVD-----VATGRKVI-TGEFWPIIHSD--------WW------KPEDGTKRKIMAECLIPHVIVPEAIHSIFVAH-----PSVADTVRSIIAE----I-PC-PVEVVTEPHLFF
161528666       QYLFYITHIDNIPSMLQN--GILSHDQIVKQKLEYTSIYDSDIVSSRREK----TANGKS-LWYFANLYFQPRNP-------MLYRVTMEK-----------SPDCIAVVAVDKKILTT-------PNTIITDGNAANGPTHFYP------NTEFKTI-ERQINRITSLQ--------WW------TDSNATKRQIMAECLVPERIPPEFIRAIYVSN-----HTLADEIRNSMSS------S---ISIIPEPSMFF
156740099       KSLFYITHINNLESIFQH--GILSHARVEEMGIPYTPIYDAQIVSNRRER-S--TPDGKS-LWRFANLYFQPRNP-------MLYRVINKI-----------DKKEVAIIGVRPEVLSY-------PGCYISTGNAASSPSEILP-----VKEGIKAI-F-EMWKIIHNE--------WW------NPDDGSKRKIMAECLVPDFVSPDMIQTIYVVN-----HDVAKDVRSRISG----A-R---VPVVPEPSMFF
295087467       RYLYHFTDRRNIPSIKRHG-GLLSWSYCEK-----HKIDIPNPGGGNLSR-N--LDEMRN-LQDYVRLSFTTEHP-------MMYVAMKDG-----------RISNPVILRIDPSVVYL-------QHTMYADMNATTTKRTPNI------GKSLEDF-KKIHFSTVKAH-------------KHFDLDENERPYFQAEVMVMTFIPKKYIINLDTF----------------------------------------
307299774       KHLYYLSPVKNIPSILEH--GVMSKMAVETLEIPYDDYSDQTVQTIRERK-S---------LHEYVPLFFNTRNA-------MTFRYQKE--------------NRDFAILRLNSDLVT------HYDCLVSDRIAACSDAEIY-------TLSEPAL-KKINIEVVLST-------RNFY------DNWLLKKRLGAEILVKIDMIEPEWIECIILD------RTAEKIKGISIR----------QLRDSGYTYYF
257093309       GHLWHFTDIRNLAPIRRAG-GLYSWAGLGA-----LGISDAYMLANDFSR-SCDARLG---RDRYVRLSFIPNS--------WFFQRVRWS-----------CPQAVWLRFSLKAVTL--------GEVDYSLGNAASGFVALRDDLPS--MGINWDM-VTPSPPHPCDKGPTRYPTLYPDQVGDPFLFRQISNAWNSEVLIKHYLPLD-FCTGVFDC----RSGEALNI---------------------------
84392321        PFLVHFTNLKNLESIFNN--GLVPRSQLDA-----SDSEYESNDDSRLDG-----------HEDSVSTSVAFPNC-------QMFYKLRRN-----------SDDKFCLLALDPELLLN-------HSSAFCKYNAADAAISSQNIET---LKTAEAF-EGMFTELATQR---------SR--EDQKLEDYDPTDVQAEILVFDTIPKGYIGAVVFP---------DKETEKQFKG--IIG-G---CKSYVHNPNKG
218779300       EEIVHYTTMNGLIGILAT--KMVKSRERVA---QESLLEYILQLNTPLRK-----DTG---WLDYVSLSISNMNS-------WLFHFSSKKWH---------TNSKFCILSFKPEILSH-------NGVFFATTNNMYPAVRRG--------EGETGF-EALFAPIVLGRY----NAPIIR--SP-TCHDSCPTCEQAEILYPGELSTDFLLRIYVEE---D--DDEDSVHGIFGG--VGH-AK--VPVEINPGKFR
125718682       HRLCHFTHVSNLSNILKG--NIFSSRSIPR--DQWNDSDRVDGYIDYVCT-S---------VELPNSYCLKN----------MVRKTQTNI-------------EEWIIFKINPYIID--------DTSLFCPLNAAKECGKYVSEG----VEAYESI---FLNEG-RTRN-------------P-KWISSVPSNLQAEVLIKGIIPINQIKGVIFHE---N--FVDDDIFKLVNQ--AN------IEIRQSTDLFD
281416943       TRLCHFTKLKMLTHILSSNEGILASA-CIRSDV-KTVIDADRYEGEPEYV-C---------CSIEYPNSWFLSE--------AQRRDTDQIF------------RDWVVLYINLRILNY-------RDAKFCPCNASKGCGRYI-------FSDLNKL-ITLYFSPTVVGR-----------LRTPNMLECCPTDDQAEILIKNSIPRDYITGIAVGN-----NDIAERVSAILKT--YSI-FG--MRIFIAPDVVS
113473935       EYLCHFTPAPNLPNIIAH--GLLCRAHLST-----AGMPAYTSIDHRLDG-----------EDQAISVSISAINH-------RMFEAKRAAS----------GRTDWIVLFLCPSILWT-------HECRFYARNAARREMLDHRG----FLGGPWAF-NRMFSESSHPNGFTG--YSYRVDT---GIADALTTYSDAEIQVLEPISPEYVIGAWANN-----MPLAEIAQSCLNR--LSG-SE--RDVQVSSPHRV
60461910        DHLVHFTNINNIDNIMRH--GLLNTQDLKE-----QNIPFIFTDEYKLDG------------RHGLSLSVQFPNY-------KMFYSKTNKS----------PQNDMVVLLLDPELINE-------KKCLYFYDNAATTELKNMSSSD---LMTDIAW-EKMFSDKVDGI---------LR--SELKIPNSFTTNPQAEVICLEPIEPKYIKNIICK---------SDDQFGRVSN--Y-------LDIVGKDEHYF
260557664       KSIFHFTRVENLNNILTN--GIIPRNNLSN-----KTSIF--NDTVRADG-----------KLDYSSFSISFPNH-------LMFYRLRCAV----------PESKWAILVFKSDLLTT-------NNCLFYPVNAASSNVSRSPVDM---FRGGQAL-ERMFTYSAESR--------------ESVLRACDPTDVQAEVMIPGIVTMENLKGCILS---------EKDLVEFFSK--RFP-N---IKFVHCHSGRQ
153817479       EYLWHFTKLENVSSIFQS--GIVPRATLEA-----NQSNVAYNDQHRLDG-----------FKTASCFSIGHPNY-------KMFYSLRQQD----------PSVEWVVFGVKAEVLWT-------KDCAFCTTNAANSSVTSVPIEQ---RKGVQAF-ESLFLPVAGKP---------SR--QELQLPDDCPTDPQAEVLVFDTILPSDIVGVIVP---------TKAKELELKP--LYP-A---HQVVYHRAHYS
239627870       EHCVHFTNVLNLPSILSY--GLLSKADLEY-----NWIEYNHNDNLRLDE-----------FEESISVSITSPNY-------KTFYQWRCDN----------PSKSWVVLILDAIQILN-------LDCAFCYTNAANIRISSIPLAE---RKTYSAF-ESMFAEKQNQA---------TR--QEMKLYPNEPTDPQAEILVFNSIPVSAIQFALFN---------DYQIMKQYAP--LLD-N---ANIPYTRDLGY
149186577       GHLVHFTQAENLASIMQN--GILSVSSLRR-----RGISFRQNDISRYDY-----------QINASSLSITHPNE-------KLFYKWRMED----------PSQDWVVLLIESSILRR-------RDLAFNIHNAADKRMSSRPLSA---RKGVDAF-EGMFAEIDGFA---------KR--AELGLRDQDTTDVQAEVLAFQKIEPRLILGAVFD---------SLGAMARYSN--ILG-N---RDISCVQPNTG
71064898        QILCHFTPINNLESILNN--GLYPRDYIDE-----NLPDAIWTDDGRFEG-----------MKNGVCLSISFPNH-------QMFYRKRMQLK---------DIESWAVIVLDARVIKL------NHDCAFFQTNSAFGDYRNKSLSE---FMTSNAF-FSLFEEKVETRN-----GVVTR--QD-YLTDEFPTDVQAEVVVFDHIPPDSIEACYLQ---------SEKYLKYFEE--KFS-K---FTFIEDSNDNS
294664142       KALFHFTREENLASILSR--GLLRRDQL-S-----SSEGAVFNDDLRLDR------------TSAICLSVGFPNY-------KMFYPLRINN----------PDTKWVVIAVMPSVLWM-------LPCAFCTTNAASNAVTASTLAQ---RMGLAPF-QNMYGDCSGKI----------R--SSLGIPNDYPTDPQAEVLVLNDIPPAYLMGLATH---------TREGKDRILS--RHA-G---THVIHAPTLFS
237813317       RNIVHFTRLSNLASIIAN--GIVPRSTLVA-----KNLLFEYNDAYRHDG-----------YLNASCFTIGWPNY-------KMFYPIRCSN----------PDVNWAVIECSPAILWE-------KPCIFSAQNAASNAARLVPLEQ---RTGLSGI-TGIFAEIPGKP---------TR--AEMGVHESFPTNPQAEVLVCDIVEPRYFVRVHIE---------DWASRNKLAA--EY------HPLPFVTGWEG
189425638       SHLVHFTRLENLEGIMRQ--GIRTRYDLDN-----SGTGYIYNDDLRLDG-----------YPNAASISVSYPNY-------KMFYSYRCAD----------HNVPWVVLRLRPDILWE-------KNCAFCWENAASTNVTCIPIEN---RRGREAF-LDLFVNKSGYP---------TR--ETTLIPRSYPTHPQAEVLVFGTIEPAYITRVDLP---------TRFNPNSVFS--SIN-RH--CEFWYDDDLFW
206563731       KYLVHFTRLSNLASILAH--GLVCRNRLDG-----RNVIGAVNDQYRLDR------------TDAVCVSIGFPNY-------RMFYRYRQEN----------RGENWVVVGIDPSALWK-------LRCAFCITNAAAGRVSAIPLDQ---RTGLPAF-QAMYGDFDDKV----------R--ANLHLADQFPTNPQAEVLMLDGVPAAYFLGVAVQ---------NDMMKAQVEA--LHP-G---LHVVRHEEFYS
260590817       EFLIHFTPTINLYSILEQ--GKLMSRKTLE---NLDIEQFDILDYAQFTD-NV---RCD--DKGFINLSISGPNT-------FLFSKFQERTKD---D----MTIDWCILKIDPKYIYE-------KETKFSVTNAASNVAKAIGV-----TGDLDKF-KMLFANSINIP---------YG--IRGKINSKYPTNVQAEVLVKKDIPVESIIEVCFNSIE------SFASAKAALS--EFD-T---SNFVVDMEIFS
258545511       KYLCHFTPQNNLEHIKNY--GLLLRNEMPC--------GATITDSTRADN-----------VRSAICMTISKPNR-------WMLEQ-KQREG-----------HHLALLLISPDVLFM-------RKCLFYPHNAATASLRRRPIED---FMGIDAF-KEIFAEEVEYKK-SGKESQIIR--RSSHLSAAETTSDQAEVQCLEQISPQHIMRIITY-----NIPLDYQDVQILAG-----------KLFLNPQRYR
229129771       TRLCHFTNSRSFIHIIQNDLGVVANNFLGD---EEEIGIMSKNDNLRLDG-----------KEDYISCSIEYPNT-------WYLDKVKLRDP---------NFRDWVVLFIDPLVMLE-------ENTLFCHRNAAAGEGKYL-------KSGNEGL-RGMFAQTVDGK-------FKIN--RAYNMLSCCPTDGQAEVMVYKNIPKESIKGVCVSSMEQVKIEMLKISHLNLLE--GEL-N---FDWIISPELFS
30022567        TRLCHFTNSRSFIHIIQNDLGVVANNFLGD---EEEIGIMSKNDNLRLDG-----------KEDYISCSIEYPNT-------WYLDKVKLRDP---------NFRDWVVLFIDPLVMLE-------ENTLFCHRNAAAGEGKYL-------KSGNEGL-RGMFAQTVDGK-------FKIN--RAYNMLSCCPTDGQAEVMVYKNIPKESIKGVCVSSMEQVKIEMLKISHLNLLE--GEL-N---FDWIISPELFS
224477788       TRLCHFTKSKNLPFILGEGVDSDNGILANN-----FISDTSFLNKTDENR-FD-------NHEDFICTSIQYPNC-------YYFSTVVKKNQ--TE-----IFNEWTILGISPEIID--------DSTKFCPVNAATKGGRMI-------GNGAEAF-EEVFSERVEGKR-------IF--VRNQNYPDNVPTNVQAEVLIYNKIPKENITSLIFPT---EAIAEKECLRLELCG--VNV-SQ--YDIIVSSDLFE
237800583       ESILHFTSNSGALGVFAS--RALKSRQRLN---ADQQLKHIFQPNARFRD-KD------VAWLDYANLSISQINT-------AFFKTCSGSWH--KE-----KDFFWCILDFSPSIMLH-------DDVWFTTTNNIYTGVKRA--------CGVEGL-EAVFQPT-THQY----QANYVR--RPADHPSNLPTCYQAEILYPQELSTDYLQRIYVRC---D--NDTDELAGQMAA--TRH-PQ--VEVVVRPELFE
325690156       TRLCHFTKSSNLPYILGGTDEEANGIISNK-AIRDSECKFLKLNDIHRYD----------NRPELICLSVEYPN--------FFFFEKSIEKE--KES----LLNDWVVLLISPSIIN--------EETYFCPVNAAKNRGAHIG------KGSQKFM-ELFNTEVLGLNR-------------SVSMLPNIPTNNQAEVLSPDMIPKDKIIGLVFSS---KKQARDEVLRLKLCQ--IEL-RN--LKIYYSHEWFK
148821249       WIVWHFTHADNLPGIITAG-RLLADSAVT---PTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSP-------MLYVVCKGHSG--YSG----GAGPLVHLGVALGDIID-----ADLTWCASDGNAAASYTKFS--------RQVDTLGTFVDFDLLCQR--------QW---HNTDDDPNRQSRRAAEILVYGHVLFELVSYVCCYN-----T-ETMTRVRTLLD--PVG-GV--RKYVIKPGMYY
15607201        WIVWHFTHADNLPGIITAG-RLLADSAVT---PTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSP-------MLYVVCKGHSG--YSG----GAGPLVHLGVALGDIID-----ADLTWCASDGNAAASYTKFS--------RQVDTLGTFVDFDLLCQR--------QW---HNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYN-----T-ETMTRVRTLLD--PVG-GV--RKYVIKPGMYY
90419305        ALIFRIVHRDNVEWILDN--GLHCKKAHVS-DPNYVAIGNLELIDRRTNH-PVPCHPNG-TLGDYVPFYFTPFSP-------MMLNIKTGYGG-IRKR----ANEEIVVLVSSLHKLNE-----AGLPIVFTDRHAYLQAARFY--------TDMQRL-NEIDWAILRAK--------DFK--RNAEDPGKF-ERYQAEALVHRSLPCAGLLGIACY-----NEAVMASVKRQTER--RGL-N---MRVIAQRKYYF
307823108       ALIWRIVHRDNLSWILDN--GLHCANSKTL-SPNYINIGNSDLIDKRRHR-VVPIAPSG-TLADYVPFYFTPFSV-------MMLNIHSGRGG-VPRR----RNEEIVILVSNLHHVHS-----IGLPFLFTNAHAYPNWTNYY--------SNLAQL-YNIDWDILQRR--------DFK--RDPDDLRKM-ERYQAEALIFKHLPINGILGIVCY-----TEQLKHDIEQQVQD--RNL-M---LEVYARTKWYF
228911570       TFIYHMTHYRNLSKILSSN-GLVCVSNIMNNGQTYCNIANNDIQSRRASY-SVPVEPFG-TLHKYVPFYFAPKSP-------MLYSIYKGNVI-QYNE----GQEPLIYFVSSAQKIKQ-----NGVPFCFTDGHGIMHFTEYY--------NDLTEL-HNIDWDIMKSK--------YWHDT---IEDNDRKRRRMAEFLVYQYVPLDCIIGIAVYS-----QKYKEETEKILTE--HNV-S---LPVKLKPNWYY
309811906       PGIVHFTRVEHLGTIVQQ--GLLSDHAVGS--ALQHEIGNRNIKAQRTRR-VVPIPPGG-VVADYVPFYFAARSP-------MMYSIAMGNVP-GYAE----GTARIVYLVSDVGRVLT-----DGMRVVISDRNAALHVAAFRP-----PTVELFAG-DFIDWDLMRAR--------YWGQYDDGSTRADGRERRMAECLVHQKVSWGCITHVVAKS-----EAVAREARLLLGD--RLP-P---GGVVVRPEWYF
326943719       TFIYHMTHYRNLSKILSSN-GLVCVSSIMNNGQTYCNIANNDIQNRRAYY-SVPVEPFG-TLHKYVPFYFAPKSP-------MLYSIYKGNVT-QYNE----GQGPLIYFVSSAQKIKQ-----NGVPFCFTDGHGIMHFTEYY--------NDLKEL-HNIDWDIMKSKY-----------WHDTIEDNDRKRRRMAEFLVYQYVPLDCIIGIAVYS-----QKYKEETEKILTE--HNV-S---LTVKLKPNWYY
292493384       GLIFRITHRDNILWILDH--GLHCPNGTVF-DHNFVPIGNPELIDRRHHR-EVPIPPGG-VLGDYVPFYFTPYSP-------MMYNIKTGYGG-VKKR----RNDEIVVLVSSLHQVAK-----EQRKFVFTDRHAYLRAANFY--------NNINDL-NLVDFKLLRSR--------DFS--RDVEDPEKI-ERYQAEALVHQSLPVQALLGIVCY-----TKAVADEVQSVLRV--RKI-T---MRTLVKPSWYF
257455836       GLIWRIVHIANLPWIFAN--GLHSGNSPIQ-SPNWQHIGNPELIQKRANH-PVPVGRQG-YLNDYVPFYFTPFSP-------MLLNIKSGRG--VMQR----PMQDIVILVSSIDTVES-----QHLDYVFTNSHAYYQWTNFF--------TDRKDL-DKIDWALLQRR--------DFS--RDPNDLAKF-ERYQAEFLIYQHCPISAIIGICCY-----NDNVKQSIQQLINM--SGI-T---LDVHSRPNWYL
215486216       ALIWRIVHRDNIPWILDN--GLHCGNSLVQ-AENWINIGNPELIGKRAGH-PVPVGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKRR----PNEEIVILVSNLRNVAA-----HDVPFVFTDSHAYYNWTNYY--------TSLNSL-DQIDWPILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPISLLDGIICY-----SEEVRLQLEQWLFQ--RNL-T---MSVHTRSGWYF
256023435       ALIWRIVHRDNIPWILDN--GLHCGNSLVQ-AENWINIGNPELIGKRAGH-PVPVGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKRR----PNEEIVILVSNLRNVAA-----HDVPFVFTDSHAYYNWTNYY--------TSLNSL-DQIDWPILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPISLLDGIICY-----SEEVRLQLEQWLFQ--RNL-T---MSVHTRAGWYF
304560215       ALIWRIVHRDNIPWILDN--GLHCGNSQVQ-AVNWINIGNPELIGKRAGH-PVPVGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-ITQR----PNEEIVILVSSLRSVAA-----QNAPFVFTDSHAYYNWANYY--------TRLEDL-NQIDWSILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
238921299       ALIWRIVHRDNIPWILDH--GLHCGNSPVQ-AANWINIGNPELIGKRAGH-PVPVGMGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-ITQR----PNEEIVILVSNLRNVAA-----QNIPFVFTDSHAYYNWVNYY--------TRLDDL-NQIDWSILQAR--------DFR--RDPDDPAKF-ERYQAEALIWKHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
269140415       ALIWRIVHRDNIPWILDH--GLHCGNSPVQ-AANWINIGNPELIGKRAGH-PVPVGMGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-ITQR----PNEEIVILVSNLRNVAA-----QNIPFVFTDSHAYYNWVNYY--------TRLDDL-NQIDWSILQAR--------DFR--RDPDDPAKF-ERYQAEALIWQHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
253687260       ALIWRIVHRDNIPWILDN--GLHCGNSPVQ-AGNWINIGNPELIGKRAGH-PVPAGAGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKQR----PNEEIVILVSSLRTVAA-----QNVPFVFTDSHAYYNWANYY--------TDLNNL-NQIDWPILQAR--------DFR--RDPDDPGKF-ERYQAEALIWRHCPITLLSGMVCY-----NDSVKLQLEQWLSQ--RNL-T---MPVHARAGWYF
104779562       ALIWRVVHRDNLPWLLDN--GLCAVSRGNL-SSGYVGIGNPDLISKRSRR-AVPIHPGG-TLADYVPFYFTPFSV-------MMKNIHSGRG--VQQR----RNEEIVILVSSLYHVRS-----LGLPFVFTDAHAYPDWAGYY--------SDLEHL-DKIDWQILQSR--------DFK--RDPDDPRKM-ERYQAEALIHGHVPVAGLLGIVCY-----NEALQRRVDQEVRQ--RQL-D---LPVHARPGWYF
206579710       ALIWRIVHRDNIPWILDN--GLHCGNSPVQ-AANWINIGNPELIDKRAGH-PVPAGTGG-TLHDYVPFYFTPFSP-------MLMNIHSGRGG-IKQR----PNEEIVILVSSLRHVAT-----QNVPFVFTDSHAYYNLANYY--------TDLNNL-HRIDWPILQAR--------DFR--RDQDDLAKF-ERYQAEALIWQHCPITLLVGMICY-----NDGVRLQLEQWLSQ--RNL-T---MPVHARAGWYF
288457846       ALIWRIVHYSNLPWILDN--GLYCGNSKIK-SPNWFNIGNPELIQKRADH-SVPLPPSG-MLNDYIPFYFTPFSP-------MLRNISTGWGG-IPQL----PNEKIIILVSSLHHIAD-----LGLPFLFTDSHAYSPCANYY--------SNLSDL-NQIDWPILQHR--------DFK--RDPDDPAKF-ERYQAEALIYQHLPINGLYGIICY-----TELLKQRIEQEICA--RNL-N---LRVYARPEWYF
146305602       ALIWRIVHRDNLVWILDN--GLHCASANVQ-APNYVVIGNVDLISRRRER-TVPVAPGG-TLSDYVPFYFTPFSP-------MMYNIHTGRGE-VQQR----HNEEICILVSSLRRVHE-----LGLGFAFTDRHAYTPLARYF--------NELDLL-EQLDWPLLQAR--------NFS--RNPDDPEQI-ERYQAEALVHRYLPIEGLLGVVCF-----TQAVKDRLDAQAQA--KGL-K---LDIRVMPQWYF
209527878       TYIYHITHLKNLPSILRSE-GLLANNHLKSQPINYVDIAHETIQNKRAQI-NIPCSRGG-TLHDYVPWYFAPRSP-------MLYAISRGNVQ--GYE----QGQSPVIHLVATAEDIA----AASLPFAFTDGHAIVRYSEFY--------DNLDSL-NAIDWEIMNAG--------YWA--DTLEDGDRK-RRRQAEFLVYEFFPWTLVREIGVI-----DAGRKAEVEEILQN--FTI-S---TPVKVFREWYY
209527890       TYIYHITHLKNLPSILRSE-GLLANNHLKSQPINYVDIAHETIQNKRAQI-NIPCSRGG-TLHDYVPWYFAPRSP-------MLYAISRGNVQ--GYE----QGQSPVIHLVATAEDIA----AASLPFAFTDGHAIVRYSEFY--------DNLDSL-NAIDWEIMNAG--------YWA--DTLEDGDRK-RRRQAEFLVYEFFPWTLVREIRVI-----DAGRKAEVEEILQN--FTI-S---TPVKVFREWYY
300868768       TFIYHITHINNLESIVKAG-GLLACNAMYEANAEYTNIAYDGIQDRRART-SVPCSVGG-VLHDYVPFYFAPRSP-------MLCAINNKGKVK-GYS----EGQTPIIYLVSEVEKIA----DSNLHFAFTDGHAVMTFTDFF--------DNLEYLDEAIDWEVMESR--------YWF--DTDEDNDRK-RKRQAEFLVYKFFPWQLVTEIGVK-----NYQIKTEVDKILEKN-TTH-Q---PPVKTRTAWYY
119483244       TPIYHITHIDNLVSIISSG-GLIACSQLRQQQVRYTDIAHQNIQDRRANK-PVPCSVGG-LLHDYVPFYFGPRSP-------MLYAIYRRNVQ--GYQ----GSQSSIIHLVTEIETIA----NSDLDFAFTDGHAIMDYSDFY--------DDLWQLGEVIDWGLMEER--------YWS--DTEEDRNRK-WRRQAEFLVHRFYPWRFITAIGVI-----NDSIKTKVQSILQK--KQH-Q---PLVRVCSNWYY
307154521       PSIYHITHLNNLASILRAG-GLIANSRLRQQQINYTDIAHEQIQDRRARK-RLPCGAGG-TLHDYVPFYFAPRSP-------MLYAIHTGNVR--GYQ----DGQDSIIHLVTDIEAPFF---EEENAFVFTDGHAIMDYSDFY--------DDLNALDFVIDWELMKSK--------YWF--DTEDYPDRK-WRRQAEFLVYERCPWDLITEIGVI-----NSTIQLRVQNILKN--FSD-L---TPVRVYPNWYY
218295754       TLIYHITHLNNLQGILQRG-GLLPYSQRPPTQ-QNVAYGHIQAHRAQVVV-PVGPR--G-KLHDYVPFYFCPRSP-------MLYAIHTQQT---DYQ----GDQRPILHLVSSAQKVA----EARIPFVFTDRHAAVQYVCFF--------HKLEHL-KALDWQAIQAS--------YWA--------NVR-EKKQAEFLVKDFFPWELVEEIGVI-----DKTIQAQVESILAQFPDLH-H---PPVRVRRSWYY
310818319       PLIFHITHVDNLPNILREG-GLWCDAQRIARGLSSTNIGHLHIKQRRLLR-PVTTTAGG-TLGDYVPFNFCSRSV-------MLYAVHCGHQ---DYK----GGQESIVHMVSSVSRATA----LGRAWAFTDRHAELAHALHF--------DDLGKL-GEVPWQVMPLQ--------YWS--------EVK-EERQAEFLVREFFPWEAVTEVAAM-----TPAASARVQQALRG--AAH-H---PPVTTQAGWYY
30249340        PKLYHIVHVDRLSSILKDG-FLWCDVHMAQHIPVGTTIGMNNIKQRRLQNC-LNSYPDL-HVGDCVPFYFCPRSV-------MLYLIYRQNT-ELDYK----GGQGPIIHLEADLNAVTTWAKTQSARWVFTLTNAGSFYFEDR--------NDLTCL-KEVNWTAVHAL--------NWK--------EHK-EGKQAEFLIEQCFPWNLVERIGVQ-----SEVIYNHVVNALPV--NGH-R---PKVEIKPEWYY
38505777        PKIYHIVHVDRLPSIIADG-CLWCDAAISQRNPAGTTIGMNKIKQRRLKELTLTSHPSL-YVGQCVPFYFCPRSI-------MLFLIHKKNT-ELTYQ----GGQEPIIHLEGDLIQAVNWADQNNLRWAFTLSNAGSSYFEDR--------NSLAQL-HEIDWAAVQAT--------NWQ--------TCK-EGKQAEFLVESTFPWHLVERIGVK-----SRVIYDQVIKALPT--GGH-H---PQVEVRPDWYY
120608868       PKLYHICHVDRLPSIIASG-GLLSDAAVVQVAAPGTVIGMNHIKQRRMTELQLTSHPGL-YVGQCVPFYFCPRSV-------MLYLIHRQNA-DLAYK----GGQGPIVHLEADLHTTVAWANGQGLRWAFTLSNAGARYFEDR--------ADLGRL-GEVDWDAVAAR--------NWS--------AQK-EGKQAEFLLERGFPWQLIERIGVL-----SQPIATQVAHALPV--GGH-R---PPVQLMPAWYY
217979677       PKIYHIIHSDRLASIIADG-FLWPDAAMAQRQGVGTTIGMSNIKARRLNELTLSCHPHL-RVGHCTPFYFCSRSV-------MLYLIYRRNE-ELTYK----GGKSRSSIWKLISTRRLL-GRNRTIGAGRLLCRMPVRITLRT-------GRTLRSL-A-INWDAVQAR--------QWS--GNAVSRSVK-EGKQAEFLIERAFPWRLVERIGVF-----SQGYVQPVSQAMQG--AAH-R---PEIEIRRDWYY
189425258       PKIYHIVHVDRLTSIIASN-GLLCDAEIVRSKPPGTTIGMGTIKQRRLNELFLSSHFGL-NVGDCVPFYFCPRSV-------MLYLIWRANDPELTYR----GGQAPIVHLEADLHQTVAWAESQNLRWAFTLSNAGAYYFEDR--------SNLDRL-GDIDWQAVEAT--------NWQ--------KCK-EGKQAEFLIEQRFPWELVTRIGVM-----TTQTHAQASAAIAA--STH-K---PRVELMQNWYY
154253368       PKIYHIVHVQNLASIVTDG-HLWSDATMVNRPPGGTVIGMGGIKLRRLRL-PVTCHQGT-HVGDFVPFYFCSRSI-------MLYVLHCANHAELTYR----GGQQPIVHLEADLYRSVRWAEENGSRWAFSLSNAGAAYTQFR--------SKREQL-SEVNWEAVRAT--------DFR--PA----DVK-EGKQAEFLVERSFPWHLVERVGVH-----SQAVVDQVSTAMRG--VRH-R---PQIEIRKDWYF
146294612       PKIYHIVHVDRLAPILASN-ALLCDAEIIAQQAAGTTIGMNTIKQRRLNELTLDSYPDL-YVGQCVPFYFCPRSI-------MLYVIHRADSAELVYR----GGQGPIIHLQADLHATVQWAQQQGRRWAFTLSNAGSYYFEDR--------NDLARL-NELDWQAIGAR--------QWQ--------GCK-EGKQAEFLMEHSFPWHLVEEIVVQ-----SPIIHQQVVNTLQR--VGH-R---PPVRINPNWYY
251788569       PKIYHILHIDRLHSIIAE--GLLSDEQISVRHGAGTMIGMSSIKQRRLHELTLTNHPNL-YVGQCVPFYFCPRSV-------MLYLIYRANHPELAYR----GGQEPILHLEADLYTTIAWAEQHRQRWAFTLSNAGSLYFEDR--------CQQSQL-GELNWEAIQSN--------QWS--GGN---GTK-EAKQAEFLIERCFPWHLIERIGVH-----SPLIYQQVANMIPL--DGH-R---PPVEVKREWYY
153872688       PKIYHIVHIDRLASIIAAG-ELWCDAQIVAQNPGGTTIGMTSIKQRRLYELSLNSHPNL-HVGDCVPFYFCPRSI-------MLYLIYQANHPKLAYY----GGQEPIVHLQADLHASVAWAHKQKRCWAFTLSNAGSYYFEDR--------CDLAQL-NELDWAAIQSN--------QWQ--------HCK-EGKQAEFLMEASFPWNLIERIGVF-----SQPIYQQTMNILQT--GVY-R---PPITISREWYY
257095819       PKLYHIAHVDRLPSIVTDA-CLWCDSEVSRRGPAGTMIGISSIKQRRLSELTLSSHPGL-HVGDCVPFYFCARSV-------MLYLIHQANHPELAYR----GGQSPIIHFEADLGAVVDWADRQGRRWAFTLSNAGSRFFEDR--------CDLAQL-GEIDWNAVQAR--------DWR--------QCK-EGKQAEFLLEHSLPWHLVERIGVQ-----SRPIFQQVSNALPA--SGY-R---PAVDIVSDWYY
284119730       PKIYHIMHIDRLASIVADD-YLWCDAKMATRTSSGTTIGMNGIKERRLTN-PLHSHSGL-RVGDCVPFYFCPRAV-------MLYVIYKANHPELDYR----GGQGPIVHLEADLRQTVVWAERQQRRWAFTTSNAGSRFFDDY--------ADLADL-DKIDWDAVHAT--------DWR--------QCQ-DGKQAEFLVQDSFPWAMVSRIAVN-----SKEIYAKVQLVLRE--ARH-R---PPVEVKPDWYY
148654473       PKIYHITHVDNIRNIVSTG-GLLSDARILQQGGPTQMIGLSNIKRRRIEELEVRCHPGT-KVGEYVPFYFCPRSI-------MLYVIHRADHPELMYR----GGQDSIAHLEADLHQVVDWADNNGVRWAFSLSNAGARYTQFR--------SNLRYL-HELDWDAIAAT--------DFR--DS----DVK-EGKQAEFLVHGFFPFDLVERIGVH-----RANIWNKVRSVLAG--SGY-T---PRVEVRDDWYF
126667035       PKVYHIVHVDRLASIIADQ-VLWSDAQVIARAPAGTTIGMSGIKQRRLNELTLTSHPDL-YVGACVPFYFCPRSI-------MLYLIYQGNHPDLGYK----GGQGPIIHLEADLNDSVAWAEANQQRWAFTLSNAGSCYFEDR--------SDLFRL-NEINWTAVGAR--------NWM--------SCK-DGKQAEFLLENCYPWHLVERVGVC-----SQAIYTQVANILAG--VPH-R---PDLQIKPDWYY
254245305       PKIYHIVHVDRLASIIRSG-ALWCDARVIRDGADGTTIGMSSIKRRRLQELQLDSHADL-YVGQCVPFYFCPRSV-------MLYLIYRGNHSELTYR----GGQGPIVHLEADLRQSVAWANANRHRWAFTLSNAGSYYFEDR--------CDLRHL-GDINWDAVQTR--------QWQ--------SDR-EGKQAEFLMEDSFPWGLIERIGVS-----SAQAYQQVVNALPA--GGH-R---PTVEVKHDWYY
261344446       PKIYHIVHVDRLSSIFASN-GLLCDAEVIFQNLSGTNIGISNIKKRRLTELQLSSHSNL-YVGQCVPFYFCPRSI-------MLYVIHRGTNTNLTYQ----GGQNSIIHLQADLYASVQWAKKHKNRWAFTLSNAGSYFFEDR--------CDLSQL-NQLVWQDIQAT--------QWQ--------NCK-ENKQAEFLMERYFPWHLVEQIVVH-----SQDIQQKVIQLLRM--EEH-R---PPVTIKSDWYY
46309426        FYLIHETSFEALSKILQGS-FLLTSSKTQKLKVRGQGSSNRRLASDPRV-----------SLTDSEFFNKYDEVD-------GVYMRLQPKMHSIRYS------KSDCVLVLRMNLLKYC------KFVINSEENFGFYIAEEC-------VIGTSQFSGEPGFTTTSFE-------KLALLK-------DTTDYSSTEVLILQDVPVSFIKFIFLV-----RDTKADTIFKPLAR--YNI-KC--FNIL-------
192290492       TAIFHITAIANLDSIAKQG-ALLSKNEAAARGLVAANIAYDHIQGRRAVR-TVPIAPGG-TLHDYVPFYFAPRSP-------MLFTINQGNVPDCIYR------QDDIVHLATTAQTVAD----TGQQIVFSDIHAALDYARFF--------SDLGSL-TEIDWRIFFEPPRLEGYCKFWQNRQIPIHHLRRLEIRQAEFLVHGELPIAAISEIGVK-----TAQAAAQVEQAVAG--SGW-T---PTVRVVPGWYF
74317508        VRLFHITAIANLPAICAAG-ALLSKNQGATNGIAYQNIAHQGAQGARSIK-SVPNPPGG-LVHDFVPFYFAPRSP-------MLLAINGGRVAGCDWR------QADIAHFETTVEHVTA----AGEDFVFYDLNATLAWSTPY--------TGLANLD-KVAWDLICESPALDGYCKYWQSKLDHARYSDRMERRQAEFLVKGMVPLVRFTRIGAI-----DRGHADVVRAILDQ--AGV-K---LPVVVKPEWYF
237654251       TRLFHITAIANLPAIFAAG-ALLSKNGGAAAGINYQNIAHAGAQGARAVR-AVPNPPGG-LVHDFVPFYFAPRSP-------MLFAINGGRVAGCQWR------QTDIVHFETTVQCLVA----RGRPFVFYDRNATLAFSTPY--------TDLAHLDTAVAWDLMTEAPQLDGYCKFWQNNPAVARYADRMERRQAEFLVRDNVPLDCMTRLGVI-----DAARQAQVLALLAQ--AGV-A---LTVDIMPAWYF
317126949       RFLLHFTRAENLNSIFRYG-ILSVSKQKSL------SLEVSRNDPNRYDE-----------FLNATSVSIHLPNN--------ILLYKYKNKFNC-----------EWVVLGIKPDIIWE------KRCGFCNENAASSNVSKIPLNK---RMSVESL-NGLFNNISGKPSR----SKLNIDK------SLT-TSPQAEVLVFEDIEPSYIWGVAFE---------SNYAKNKYKE--NIP-SS--IKIEIVPELFR
255010210       TCFYHFTDRRNLLSIKKQR-GLLSWHYCKT-----HGIVIPNQGGDADSE-NLDMRYG---LQDYVRLSFCDDHP---------MTWRLKQS------------GSNLVLLRIKIDVAWF------KETLFSDINAADQLHSHG--------GDLCHL-QKVNFAATKRH--------YVNRND-----ED-FKPHQAEVMVKTFIPLEYIINIDNPILI-------------------------------------
328871094       TQLYHFTDKSNLDSIKQN--GLFSWDHIDQ------NGIQSVMGSNEDSR-RLDKRKG---LEDYVRLSFVQNHP-------MMHAAYKRDSI----K------QPIILVIDIMVVDLL--------DVKFSDVNATSNNVIIQ--------NDT----NHIQFSIFKKD--------YFKLST-----NE-KQYFQAEVLIRNNVPASYIKRSITPNMGRKST---------------------------------
282881570       KYAFRIVHIDNIPYILEN--GIVNAAKSTKKDDSYISIGDESLIEVRRNQ-NIIHTESC--IGDYIPFYFGPRTP-------MLYTIQHGYNG---VK------KCDATNLVYLVLKISDIIKS-GFQGYFTDGHARNICSHTYE------IDKLNQL-NELVHYENVYR-------TYWSIR--EDNSGEYKRLKSAELLIENNIPTTMIAGYVVY-----DKAAHDKLVSFGID------N---EKIIINNNYYF
310778852       FNLLHITEFDNIKSILETG-GLISLRKLEV-----ENVCPKFMTS-EASR-SLDRCKG---LDAYVRLAYTTWYD-------MIPTAVFYNNL----K------NPAVIIVNCELLNKK-------RDILFTTKNAVANDAIYY--------KQ-NEIGDHINWEKVFSE--------RNY----DTQSQEYKDARQSEVMVQDIVEKDYFVCIFVETGS-----DLKDLNG--YG--VEI-KE--DNIKSIINRFG
262039223       MWIHHLTHIDNLESILER--GLISRNQLKQFNIKFNDTADKRIIGERND------------LNNYIPFHINYLQKKY-----SIPYNWKVLKNQ---S------SENMIFLNYNIDDFSN------NELDFYLYHPISKSQNNA--IK---INDLMGF-KEKLLKEEKKLQ--------NDMGYLDFSDNKTQQFLMSEVLIKDRIYLSEKWKIGVFS-----FAQKQIVEKKLEK--NNL-K---IEVFIDDKRYF
88856595        QRVYHVTHISNLENILLTG-QLVAAAQIES---PILDVSSPLTREMRGTA----SLSTGETVDRYVPFSLVPESNTWRELRDGAGEPRWSDAAR-AAS------SSDFVFLVTTIRALGT-------DAVLADGDAAAGETIFA--------TDEGAM-TRMLGNLRA-----------------------DELTEDAEVLIHGSFAFDEVQLVGVAS-----DKARDRVKELLDA--ASF-V---TKVAVYPPWFI
222529646       FGIYHYTDFTNLESIFKEG-FLYSRVDCIKKGLQFTDGADHNVLSIAPYD-----------VKNKVRFYFRPNTPTLFE-NEGIKLPAYIGK----AH------MPIPVCLLFDDELILL------DTTEFSNGNATSVKYTQI-------GCTYAFF-KSMEWDLIFHEG-----------YIEPFERNKIVNRRNSELLSTTPVSLKYLKKVIFRT-----KADFKRASNLF-G--MN------KKFCVDINYFS
126652604       RYIYHFSDIQNIVSILKCG-YVASRNFAIENGLMKNENACLDVIDKTTHD-----------NKNLARFYFRPKTPTQYH-NEGIKSKFREYEND--AH------IPVPVFLVFDAVGMFS-----KNQSMFVERNLVYSPPIK---------KHISEL-EKFDFDKIYHS-----SSLYGYSS---YDKQEIIEKRHAEVVFKDFCSLDCLRSIVCRS-----SAEKDTLIHLLRF--EGV-DVSKYRIVTNGNELL
328958126       RYCYHFSHIDNIISILNTG-KVYSRSKSKELKLMQNDNASQDVINQTNIL-----------VKDYVRLYFRPKTPTQYH-NEGLRNLRTTTTLN--AH------CPFPVFLLFDL------------KQVLTSENSFFCKHSLAHSSEYHLCNTPLEL-ANFPFSKIYHD--------RSFSGAQR---NEIISHRQAEIVVPNEMSLNTLKKIMVRSIA-----EKETLMYMLSA--DSK-KKYNELIQIDSKKIV
262383473       PKAYHFTHMDNALKIIRSM-KLQSRNLA--TGC-FSNSAGTNVLRTSK-------------AHRFARFYFVPQSPTQFY-NECLGKDSSDIRYYQKALNLGLPKCPMPVFLIFDVEELLMAM---PDKCYYSNGNMQKDASRSF--------KVVDNP-NMIKAKEIYTD--------SFS----------TKNERQQEFLIDGELDFSYLTKVQIRCY---DEYQAATLRKELLG--TKW-E---NCIKVDRSLYT
MARKUP          ..........!**???....*.....*...............................................!**...............................................................*....<--------------------.ARTT.loop.-------------------->....**!....................................................
STRUCT          .....S1..........................................................S2.........................................S3...................S4...................................................................S5............S6..................................S7.......
consensus/100%  ..h........h..h.......................................................................................................................................................................................Eh.....h...................................................
consensus/95%   ..hh.h....ph..l......h...............................................h......................................h.....................h...ps.....................h.......................................uEhhh...h....h..............................................
consensus/90%   ..lh+hs..ppl..Ih.....l.s......................p..................s...h............h........................hh.....................h...ps.....................h...h...............................p...AEhlh...h....h..h...........................................
consensus/85%   ..lh+hsp.ppl..Ih.....l.s......................c..................s.h.h....s.......hbb......................hh.h...................hs..pu.....................h...h...............................p..pAEhLh...hs.p.l..h.h.................h..............h......h.
consensus/80%   ..lh+hsp.psl..Ih....slhs.s...........hs.......R................pbssh.hs..ps.......hhb.h....................lh.h..s..............hhhs..pA.....p..........ps...h...h.h..h............b.............p..pAEhLl.p.hs.phl..h.h.................h..............h.....ba.
consensus/75%   .blaHhsp.pNl..Ilp...ulhs.s.h.........hs......pR.p..............phssh.as.pps.......hhh.hpp................p.ll.h.ss..............hhas..pA.....p.b........ps...h.p.l.hp.h..........p.b..........p..p..pAEhLl.p.hs.phl..l.h.............h...h..............l.....ha.
consensus/70%   .blaHhschsNlssIlp...GLhspsph.........ls..ph..pR.p............h.phsshhasspss.......Mhh.hpp.p.............pp.ll.l.ss...h..........hhFss.pAh....p.b........ssh..h.p.l.hphhp.........p.hp.........p.bp.bQAEhLlbp.hs.phl..l.h......p.....ph.p.l........p.....l.hp..hab
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    Multiple Sequence Alignment of the KptA family 
    PDB:1wfxA  -    -     HHHHHHHHHH--------------------EEHH--HH--HHHHHHH--------------HHHHHHHHHHHH----EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEEE--------------------------------------------------------------EEEEE---HHHH-HHHHHH-----------EEEEEHH------------------------HHHHHHHH-----EEEEEEEHHHHHH-H--------------EEEEE--EEEEE-----------------EEEEEEEE--
DOMAINS    -    -     <---------------------------------------------------------------------------------------------Helix-Turn-Helix-------------------------------------------------------------------------------------------------------------------------------------------------------------------->......................................<---!**--------*---*-------R++h!**-----------Catalytic core-------**-----------------------------------------*------------------------------->
118430933  314  40    SKTLAGILRHH--PGR-YGVR--LTRE-GWARVS--EV--VEGLRKA---------gWSWVEEWHIVGVALHDP-KGRYELRN------------------------------------------------------------------------------------------------------------------------------------------------------------------GEIRARYGHS--IP----------VNVEP------------------------------LPGEPP---PILYHGTTEEAL-PLIMERG--IMRGRRLKVHLTSSL------------------------EDAVSTGRRHGNLVAVLLVDVECLRR-R------------GLKVERMSKTVYTVD-----------WVPPECIAEVRRESL  208   Aeropyrum pernix K1                                      archaea>crenarchaeota                       
154496777  381  5     SIYLCRLLRHA--PED-AGLD--MDIH-GWVSTQ--QL--IDNVNKAg---------RHHLTMPQLEQLVATDS-KGRYRFSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------KSRIKACQGHS--IPw---------VEPEL------------------------------TPAAPP---AYLYHGTTERAW-NAIQDSG-YISRMSRHAVHMQADEs-----------------------KAWQSACRWRQ-APVVLKIDAQAMAA-D------------GIPFGVSDNGVWCTE-----------QVDRKYVCTEQVDRK  179   Pseudoflavonifractor capillosus ATCC 29799               bacteria>firmicutes                         
268610712  382  5     SKYLCLLLRHQ--PEK-AGLD--MDEH-GWVSIE--QL--INGVNCHs---------SYKLDRELLEQIAAEDN-KGRYRFDEK----------------------------------------------------------------------------------------------------------------------------------------------------------------HEKIKCCQGHS--IPw---------VEPEL------------------------------EYCEPP---EFLYHGTTAKAL-EAIEESG-AIKKMKRHAVHMQADIg-----------------------KAWQSAERWHK-TPVVLKIAASEMNK-D------------GYKFGVTENEVWCTE-----------EVPVKYICTEEVPVK  177   Ruminococcus flavefaciens FD-1                           bacteria>firmicutes                         
116252353  384  11    SKYMSYVLRHA--PDA-AGLT--LDSG-GWVSFD--EL--EKALASK-----------YDVSRAEIIEIVENNP-KKRFTLA------------------------------------------------------------------------------------------------------------------------------------------------------------------HNRIRANQGHS--VD----------IDLAL------------------------------NQAEPP---AALFHGTSLTNW-QSIEREG--LKKMQRHHVHLSADVe-----------------------TAKIVAARRKG-EHIILRVDAARMFS-E------------GHSFFVSDNGVWLAE-----------SVPVQYLLAESVPVQ  177   Rhizobium leguminosarum bv. viciae 3841                  bacteria>proteobacteria>alphaproteobacteria 
124003655  387  1     SKRLSYVLRHR--PEE-IELI--MDEE-GWVEVD--LL--LDRFSNN----------YFPITLADLQKVVAQND-KKRFAFSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------EAYIRASQGHS--IQ----------IDLGY------------------------------EAIKPP---AQLYHGTATRFV-HSIREQG--LKKRNRHHVHLSADI------------------------DTATKVGGRHG-QPVILTVNALDMQQ-D------------GYKFFQSENGVWLTD-----------QVPVQYLEFPEENVQ  181   Microscilla marina ATCC 23134                            bacteria                                    
338211687  389  6     SKFLSLVLRHN--PAL-IGLD--LDAN-GWAPVK--EL--LAKMKAK----------GHGISMEELKHIVETNS-KKRFAFSEN----------------------------------------------------------------------------------------------------------------------------------------------------------------FEKIRANQGHS--VE----------VDLGY------------------------------EKQVPP---AVLFHGTAEKNF-DLILKDG--IKKMSRHHVHLSQDI------------------------TTARKVGMRHG-KPVVLSVDAKGMAD-G------------GFDFYLSNNGVWLID-----------FVPAEFIKVDDCFAE  176   Runella slithyformis DSM 19594                           bacteria                                    
312888255  390  2     SKFLSLVLRHQ--PEL-IGIE--MDEQ-GWVKVT--DL--LEKANAH----------GKALNMDVLKYVVDTNA-KKRFAFDES----------------------------------------------------------------------------------------------------------------------------------------------------------------QTYIRASQGHS--VE----------VELGY------------------------------LPQIPP---EILYHGTGSQSV-DAILKTG--LEKRARQHVHLSHDV------------------------ETATKVGSRHG-KPVILKVLAADMHQ-Q------------GYAFYLSENKVWITD-----------GVPAQFLEVFGVPAQ  180   Mucilaginibacter paludis DSM 18603                       bacteria                                    
110638931  391  14    SKFLSLVLRHQ--PEL-IGLQ--LNEQ-GWAHIE--TL--LEKSAAY----------GVSFDKQTLKYLVATNS-KKRFAFSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------AEYVRASQGHS--VD----------IELGY------------------------------KNQKPP---EILYHGTAEKFM-QSILETG--LEKCRRQHVHLSSTI------------------------ETAIHVGQRHG-KPVVFTVLAQQMYA-N------------DFSFYLSDNGVWLTD-----------HVPVIYLTINPVPVI  191   Cytophaga hutchinsonii ATCC 33406                        bacteria                                    
146298511  395  1     SKFLSLVLRHS--PEK-IGLK--LDEN-GWADVN--EL--IEKCTKK----------GNRLDAELLDYVVENND-KKRFAYNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRASQGHS--IS----------VELNL------------------------------AETEPL---EYLYHGTVGKFM-ESIQKEG--LKKMSRQHVHLSKDK------------------------ETAVKVGSRRG-VPQILTVRSGAMYR-D------------GFKFYLSENNVWLTD-----------EVPPKYIEFKSVPPK  180   Flavobacterium johnsoniae UW101                          bacteria                                    
256419129  396  1     SKFMSLVLRHQ--PET-IGIT--LDEN-GWTDVE--EL--LTRMSQH----------KHPITLAQLQEVVETND-KKRFAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRASQGHS--VD----------VSLGL------------------------------DPVTPP---EYLYHGTVARFL-DSIKKEG--LQKMSRQHLHLSKDR------------------------ETAVNVGSRRG-APYILTIRTGQMHR-D------------GFLFYLSDNGVWLTD-----------HVPPAYIEIDHVPPA  180   Chitinophaga pinensis DSM 2588                           bacteria                                    
163754445  398  6     SKFLSYVLRHN--PDK-LGIT--FDSN-GWTSVA--IL--LEKINVE----------PYSLSMEELEYVVATNN-KKRFAFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTMIRASQGHS--VN----------IDLAL------------------------------QPKEPP---SYLYHGTVEKFI-TSIQEKG--LIKGTRQHVHLSADK------------------------ETAINVGSRRG-KPIILTIRSGEMYA-Q------------HHTFYQSENGVWLTE-----------EVPTEFIEFEEVPTE  179   Kordia algicida OT-1                                     bacteria                                    
300774500  399  1     SKFLSLILRHQ--PES-IGLT--LDEN-GWADVE--EL--REKSAKR----------RIHFTPEELDEVVETNN-KKRFAFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTMIRASQGHS--VN----------IDLAL------------------------------EALQPP---DFLYHGTAETNI-ASILEKG--IEKRTRQHVHLSADK------------------------ETAAKVGMRHG-KPVILTIRTGTMYQ-D------------GLAFFQSANGVWLTD-----------FVDAKYISKDFVDAK  178   Chryseobacterium gleum ATCC 35910                        bacteria                                    
333381571  400  1     GKFLSLVLRHD--PAK-IELE--LDEN-GWANVK--EL--IEKCRKH----------RYHFSMEDLIEIVETND-KQRYSFNEK----------------------------------------------------------------------------------------------------------------------------------------------------------------RNKIRANQGHS--ID----------IDLGL------------------------------SAVEPP---EYLYHGTATRFL-SSIMEQG--IVKGSRRHVHLSKDK------------------------ETAIKVGARHG-KPVILTIMSGKMYQ-D------------GILFYQSDNGVWLTN-----------YVDVKYILKQIVDVK  178   Dysgonomonas gadei ATCC BAA-286                          bacteria                                    
213962768  404  13    SKFLSLVLRHH--PEA-IGIS--LDTH-GWAEVN--VL--IKNMKRK----------FPVFSLKILEEIVATDS-KQRYAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------NTKIRANQGHS--LA----------VTLEL------------------------------QPQTPP---ECLYHGTASRFV-ESILKSG--LQKQTRQHVHLSMDI------------------------ATATKVGARHG-KPVIFKVNTIAMHK-A------------GYVFYLSANGVWLTD-----------EVPPKFLNLIVNNPK  181   Capnocytophaga sputigena ATCC 33612                      bacteria                                    
163814521  405  4     SRFMSLILRHR--PES-IGIS--LDEH-GWANVD--EL--LSGIGEQ-----------HPIDMDMLEEIVRADK-KQRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTLIRANQGHS--IP----------VDVEL------------------------------DEVSPP---EELWHGTGEKYV-QDIETEG--LLPKSRLYVHLSNDR------------------------DTAFKVGQRHG-KPVLYIVRSGEMYR-D------------GYKFYLSKNGVWLTK-----------AVPVKYLQKQAVPVK  179   Coprococcus eutactus ATCC 27759                          bacteria>firmicutes                         
323140426  406  3     GRFLALVLRHK--PQA-VGIE--LDAH-GWAQVE--AL--LAAFNR-----------IEAFNMLMLEQIVAEDG-KQRFAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------KKRIRANQGHS--VK----------VDVEL------------------------------WEVAPP---ELLYHGTGVKYV-ASINRQG--LIARQRLYVHLSANV------------------------ETAHNVGKRHG-EPFIYVVLAGEMAR-A------------GYKFYLSANGVWLTE-----------SVPKKFLRELEGALD  176   Phascolarctobacterium sp. YIT 12067                      bacteria>firmicutes                         
154497918  407  11    SKYMSLILRHK--PQV-IGIH--LDAH-GWADVN--AL--LAGISRK-----------YSINRDILDEIVSRDE-KQRYSFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--IQ----------VDVEL------------------------------TLTEPP---EMLCHGTARRFA-ASIEAQG--LLSGSRLYVHLSPDQ------------------------ETAEKVGRRHG-EPVIYLVDAGQMHR-D------------GYCFYLSANGVWLTK-----------VVPATYLKRLEDRLT  183   Pseudoflavonifractor capillosus ATCC 29799               bacteria>firmicutes                         
167749542  410  7     SRYMALLLRHK--PEI-AGLV--LDKQ-GWADVD--ML--LKCISEN----------MEPVSFERLCEIVKNDS-KQRYSLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------KSRIRANQGHS--VN----------VDVGL------------------------------KATVPP---EYLYHGTATRFV-ESIDSGG--IIRKTRLYVHLSRDT------------------------ETATQVGMRHG-KPFIYRVKSGEMAR-D------------GYVFYLSENGVWLTE-----------NVPVKYLEKTWQDDA  176   Eubacterium siraeum DSM 15702                            bacteria>firmicutes                         
210621794  412  4     SRFISLILRHK--PET-IGIT--LDEH-GWANVE--EL--IVGVNKK-----------YPIDMQILEKIVDEDD-KNRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTMIRANQGHS--IS----------VDVEL------------------------------KKLNPP---DILYHGTGEKYV-ESIEKQG--LIRKNRLYVHLSNDI------------------------ETAEKVGKRHG-KPIIYEIDCKKMVE-N------------GIEFLKSENNVWLVE-----------SVPVKYLKKLSVPVK  175   Clostridium hiranonis DSM 13275                          bacteria>firmicutes                         
336428119  414  1     ---MSYLLRHD--KDF-------IDEH-GWAPVT--EV--IHTLKKE----------WPEFNEECLSEIVRTDE-KGRYSYDEA----------------------------------------------------------------------------------------------------------------------------------------------------------------GVRIRANQGHS--VP----------VDVEL------------------------------KEAEPP---EILYHGTADRFL-NAIMEEG--LTGRSRIYVHLSSTT------------------------ETAVNVGKRHG-KPVVLKIYAGRMRD-A------------GYKFYLSQNQVWLTQ-----------KVPVEYIETLYPEQG  163   Lachnospiraceae bacterium 3_1_57FAA_CT1                  bacteria>firmicutes                         
225388916  415  1     SVLISLVLRHK--PEA-AGIS--LDEH-GWADIE--TM--MAGMNAS----------GHRIDREMLEEIVRTDE-KGRYSLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--VP----------VDVEL------------------------------SPVQPP---EILYHGTAERFA-HAIREGG--LLPMGRLYVHLSKDV------------------------ETVVKVGSRHG-KPVVFEVESGRMYR-D------------GIPFYLSCNGVWLTK-----------AVKPRYLKGREVKPR  178   Clostridium asparagiforme DSM 15981                      bacteria>firmicutes                         
317056274  418  13    GRFISLVLRHE--PSA-AGIV--LDAE-GWADVD--EL--IHGICNT----------GRKLDMETLERIVRENN-KQRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRANQGHS--IN----------VVINM------------------------------KIMSPP---EVLYHGTSEAFI-ESIKEKG--ISKMSRQYVHLSEDM------------------------DSAVKVGSRHG-KPAVLVIDTAKMSA-D------------GFVFRISENGVWQSD-----------DIPWKYVTEIKYPWK  180   Ruminococcus albus 7                                     bacteria>firmicutes                         
167769835  419  12    GRFLSLVLRHN--PAA-AQIT--LDEH-GWADVE--AL--LAGCARA----------GRRIGRDTLERIVRENS-KQRYSFNGD----------------------------------------------------------------------------------------------------------------------------------------------------------------HTKIRANQGHS--IA----------VDVEL------------------------------RQAQPP---ARLYHGTAMRFL-ESIRAQG--ITRQSRQHVHLSADY------------------------PTALAVGSRHG-RPVVLAIDAAAMAR-D------------GYVFYRSENGVWLCE-----------RVPWSYVLEDGAGLA  179   Anaerotruncus colihominis DSM 17241                      bacteria>firmicutes                         
260889106  421  2     GKFISLILRHK--PEM-IGIE--LDRN-GWANVD--EL--INGINRS---gdvengkEERINFEILEEIVRNNS-KKRYEFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------FTKIRACQGHS--ID----------VDLEL------------------------------KAVKPP---RILYHGTADRFL-EQIKKEG--LKKKSRQFVHLSETE------------------------ETAYSVGQRHG-KPFIIKVLAEKMYE-D------------GKEFFISKNGVWLTD-----------DIEVKYLEFDDIEVK  186   Leptotrichia hofstadii F0254                             bacteria>fusobacteria                       
225620034  422  12    SKFVSLVLRHK--PEY-IGLE--LSKD-GWANVY--EL--IEKIKSK----------GRNINKDILERVVLYND-KKRFRFNEN----------------------------------------------------------------------------------------------------------------------------------------------------------------HTLIRANQGHS--IN----------VDLQF------------------------------EEKEPP---EILFHGTSINNI-DSIKHEG--IKKMNRLHVHLSLAE------------------------ETAKKVGERHG-KPTIIKINSKQMYE-D------------GIKFYLSENKVWLCD-----------YVDPKYIIEVIVDPK  182   Brachyspira hyodysenteriae WA1                           bacteria>spirochaetes                       
167757534  423  8     GKFISLILRHK--PEL-IGLK--LDYH-GWAKVD--EL--LLGINNS----------GRFINRTLLDEIVMTNN-KQRYQYNED----------------------------------------------------------------------------------------------------------------------------------------------------------------HTKIRANQGHS--IK----------VDIEL------------------------------IEKIPP---EYLYHGTAFKYL-NKIEQEG--IKKMKRLYVHLSKDI------------------------ETAFKVGSRHG-KAIVLVIDTKAMCE-D------------GCKFYYSQNGVWLTE-----------DIDYKYVMEVIKDYK  176   Clostridium ramosum DSM 1402                             bacteria>firmicutes                         
237742025  426  5     GRFISLILRHK--PET-IDLK--LDKN-GWANTK--EL--IEKISKS----------GREIDFEILERIVNENN-KKRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRAVQGHS--ID----------VNLEL------------------------------KEVVPP---AILYHGTAFKNL-ESIKKEG--IIKMSRQYVHLSADV------------------------ETAKNVATRHSGKYIIFEIDTEAMLK-E------------NYKFYLSENKVWLTD-----------FVPCKFIKFDFVPCK  179   Fusobacterium sp. 4_1_13                                 bacteria>fusobacteria                       
110800227  428  7     SKYISLILRHK--PEE-IGLK--LDEH-GYLGVL--DL--IEGLNKS----------YEGFSMDDLERIVREDS-KGRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------KSKIRANQGHS--IK----------VDLGL------------------------------EPIKPP---KVLYHGTGRKYL-ESILKNG--LIKKERNYVHLSKDI------------------------ETASIVGKRHG-DLVILEVDSESMFN-D------------GIKFYLSKNNVWLCN-----------YVPKKYIKELNLEEV  177   Clostridium perfringens ATCC 13124                       bacteria>firmicutes                         
150018230  429  10    SKFISLILRHK--PEE-IGLT--LDEY-GYISTP--DL--IKGLNKK----------GYKVTISDIERIVAEDG-KQRYSFNND----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIKANQGHS--IK----------VNLEL------------------------------QAIKPP---KVLYHGTASRFI-DSICKEG--IKKQNRQYVHLSADI------------------------ETATKVGKRHG-ELVIFKINSEQMNK-D------------GYKFFLSENKVWLTD-----------YVPVKYFEVFRTNVK  179   Clostridium beijerinckii NCIMB 8052                      bacteria>firmicutes                         
224542154  431  1     SRRLSYILRHC--PES-IDLE--LDDH-GYGDVN--KI--LEAL---------------NITIEDLDMIVREDE-KQRYSYNGD----------------------------------------------------------------------------------------------------------------------------------------------------------------HTRIRANQGHS--IP----------VNVDL------------------------------KEVQPH---DILYHGTATRFV-PSILEEG--ILSQTRIYVHLSQDI------------------------ETAMTVGSRHG-EPYVFTIDTKQMYE-D------------GYKFYLSENNIYLTK-----------IIPAKYLKASTIPAK  168   Catenibacterium mitsuokai DSM 15897                      bacteria>firmicutes                         
255103268  433  6     SIFISLILRHK--PET-IGIK--LDDY-GYADVN--EL--IEKINNT----------GRNINIEILEQIVKEDN-KQRYSFNDD----------------------------------------------------------------------------------------------------------------------------------------------------------------RSKIRANQGHS--IN----------VNVEL------------------------------RELEPP---KYLYHGTATRFL-DNIKNEG--IIKQSRLYVHLSRDI------------------------DIAVKVGKRHG-TPVILKINTGKMYE-N------------GYKFYLSENNVWLCE-----------YIPFKYVEIFEIPFK  177   Clostridium difficile QCD-63q42                          bacteria>firmicutes                         
149175185  443  1     SKFLSLILRHQ--PET-VGIT--LDES-GWVDVD--IL--LAAMSQQ----------GKGMSRATLNTVVQSND-KQRFSFNAE----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRANQGHS--IS----------VDLGY------------------------------TTAVPP---EILFHGTPEKFI-EPISREG--LKKMNRHHVHLHVDE------------------------QTSIAVGRRRG-RPVLLQVRAREMHQ-A------------GCEFFVTPNQVWLTE-----------SVPVEYIDFPSVPVE  181   Planctomyces maris DSM 8797                              bacteria>planctomycetes                     
87311897   444  4     SKFLSLVLRHQ--PDK-IGIE--LDEQ-GWVEVA--TL--LAAIRRE----------SRPLTLAQLQEVVTRND-KQRFMFSSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRAVQGHS--IE----------VELGY------------------------------EAAAPP---EYLLHGTPEQSV-AIILETG--LKKMKRHHVHLHHDR------------------------QTASAVGQRRG-KPVLLQIAAGRMHA-D------------GYSFYVTPNQVWLTD-----------EVPPAYLSILEVPPA  183   Blastopirellula marina DSM 3645                          bacteria>planctomycetes                     
163849264  446  25    SKFLSLVLRHR--PEQ-IGLS--LDQH-GWAEVD--EL--IRCANRH----------GLPLSRAQLEQVVAEND-KQRFAFSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRANQGHS--LP----------VDLQL------------------------------TPAQPP---PVLYHGTAERFV-ESIKRDG--LLPGKRQYVHLSQDE------------------------TTALTVGQRHG-RPVVLTVHAAAMTA-A------------GYVFYVSANGVWLTK-----------QVPARFIEFPAVPAR  205   Chloroflexus aurantiacus J-10-fl                         bacteria>chloroflexi                        
171913881  447  4     SKFLSLVLRHK--PEE-IGLV--LDEA-GWASTD--KL--IDACNRH----------GPGLDLPTLQLLVNTNE-KKRFEFNAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GSRIRASQGHS--VE----------VDLGY------------------------------TPQVPP---AVLHHGTVEDFL-DPIRSQG--LVKGERHHVHLSADP------------------------AIARIVGTRHG-KPVVLTVQASTMHT-A------------GHPFYLSTNGVWLTD-----------HVPARFIDFPSVPAR  183   Verrucomicrobium spinosum DSM 4136                       bacteria                                    
223939130  449  7     SKFLSLVLRHE--PGR-IGIQ--LDSA-GWVDVD--EL--LRACTAH----------QFPFSRDELNQVVATND-KKRFAFSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRANQGHS--VE----------VELQY------------------------------EPSVPP---EILYHGTADRFL-ASIQQDG--LIKGNRHHVHLSTEL------------------------STAISVGQRHG-RPLVFRVLAGQMHR-S------------GHQFFVSANGVWLAD-----------HIPANFLQIHTGEQN  177   Pedosphaera parvula Ellin514                             bacteria                                    
196229950  451  1     SKFLSLVLRHE--PEK-VGLE--LDSA-GWVEVE--ML--LAACRQH----------GVAIERAELEEIVVTNE-KKRFAFSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRANQGHS--IE----------VSLGY------------------------------TPQVPP---ARLFHGTATRFL-DSIRSDG--LKKMERHHVHLSADE------------------------ETAHKVGQRHG-KPLILLIKADAMHA-A------------NHSFFLSENGVWLTD-----------AVPVAFIEFPEDKTL  181   Chthoniobacter flavus Ellin428                           bacteria                                    
284038905  453  4     SKLLSLALRHK--PET-TGII--LDKN-GWTDVD--LL--IAKLQAQ----------SYPVNFEQLCYIVDTNN-KSRFAFNND----------------------------------------------------------------------------------------------------------------------------------------------------------------KSKIRANQGHS--VE----------VDLGY------------------------------MTEEPP---HFLYHGTATRFI-NQIIIEG--LKKMSRHHVHLSADE------------------------LTALRVGERHG-EPIVLTVKAKEMAA-N------------GHVFHRSENGIWLTD-----------FVPPSYLIYEFVPPS  181   Spirosoma linguale DSM 74                                bacteria                                    
118591032  454  6     SKRLSFWLRHK--PED-AGLT--LSHD-GWADVS--AV--LKAFSTL----------KLDCNRDQLERVVETND-KKRFEFSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRARQGHS--VD----------IDLGL------------------------------TALTPP---EILFHGTATRFL-PLILTEG--LKPMARHHVHLSPDR------------------------STALKVGSRHG-KPAVLQVAASAMQA-D------------GHTFYRTENGVWLTD-----------SVPATFLTQTETVST  176   Labrenzia aggregata IAM 12614                            bacteria>proteobacteria>alphaproteobacteria 
256394652  458  5     SKRMSSWLRHH--PEA-IGLE--MDGA-GWVRVD--EL--LAKAAAR----------GQAFSRAQLEEVVAENT-KKRFEFDET----------------------------------------------------------------------------------------------------------------------------------------------------------------ETLIRARQGHS--IP----------VELGY------------------------------ATAEPP---EVLFHGTAQNTL-TLIWRDG--LLPMKRHAVHLSPDK------------------------ETAVKVGSRHG-KPAVLAVAAARMHA-E------------GYTFFVTGNGVWLTD-----------AVPAEYLREVPALGE  173   Catenulispora acidiphila DSM 44928                       bacteria>actinobacteria                     
257063188  459  1     SRHLSYLLRHH--PEA-AGLH--MDEH-GWVRVD--EL--VAAVAQK-----------HSFDQTTLERIVATDK-KGRYSFNED----------------------------------------------------------------------------------------------------------------------------------------------------------------RTLIRANQGHS--IP----------VDVEL------------------------------ACVTPP---DRLFHGTATRFA-ESIERQG--LLPQNRLYVHLSPDP------------------------ETAMVVGARHG-KPMVYVVDAKAMSA-A------------GHRFFLSVNGVWLVK-----------TVPPEYLTRMTVPPE  177   Slackia heliotrinireducens DSM 20476                     bacteria>actinobacteria                     
149919906  460  1     GKRLAWLLRHE--PEA-WGLR--VDAH-GWMEVE--AL--LAAFAER----------GHALSRAELETHVAADG-KQRFILSSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GARIRAVQGHS--IA----------VDLEL------------------------------DERPPP---AQLFHGTPRRFV-DSILREG--LIPKARHHVHLSADE------------------------ATARQVGARRG-PPVILLVDAATMAA-D------------GHRFFVSANGVWLCE-----------RVPPEHLRVANVPPE  173   Plesiocystis pacifica SIR-1                              bacteria>proteobacteria>deltaproteobacteria 
302525419  463  1     SKRLSRHLRHD--PGG-LGLT--LAPG-GWVPVD--EL--LAALARN----------RFPVSRAELDEVVANCA-KQRFAFDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------GTLIRASQGHS--VR----------VDLEL------------------------------SDAVPP---EILYHGTATRFL-PSIRAEG--LRPMKRHAVHLSATR------------------------ETAWKVGSRHG-KPVVLTVAAGEMAA-R------------GHVFQVSDNGVWLAP-----------AVPAEFLTVAEVPAE  178   Streptomyces sp. AA4                                     bacteria>actinobacteria                     
300784169  464  5     SKRLSRHLRHD--PAA-LGLT--LTSD-GWAPVD--AL--VRALA---------------ITRAQLDEVVEKNS-KRRFAFDET----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRASQGHS--VP----------VELGL------------------------------PDTTPP---DVLYHGTVAKYL-DAIFREG--LRPMNRHAVHLSATV------------------------ETAGIVGARRG-KPVILRVDAAAMAA-E------------GHPFQISANEVWLTP-----------SVPPHHLASLTVPPH  168   Amycolatopsis mediterranei U32                           bacteria>actinobacteria                     
297564265  466  1     SKLLSRVLRHD--PAR-VGVR--LDPR-GWAGVD--EL--LAGCRRA----------GVRLSRAALQEVVDTND-KKRFVLSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRAQQGHS--VR----------VDLGL------------------------------EPSTPP---ALLYHGTVGRLL-PAITAEG--LRPMRRHDVHLSPDT------------------------ATARRVGARRG-APVVLTVASGRMHG-D------------GHVFRVTGNGVWLVP-----------AVPPEYLGEPVVPPE  181   Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  bacteria>actinobacteria                     
256379719  467  1     SKRMSRCLRHD--PGR-YGLA--LDAA-GWVDLG--GL--VRALR---------------TSREAVLEVVERNN-KRRFTVR------------------------------------------------------------------------------------------------------------------------------------------------------------------GDRIRADQGHS--VA----------VELGL------------------------------AQVEPP---GVLFHGTNAKAL-PDVLVEG--LRPMNRHAVHLSTDL------------------------ATATQVGARRG-RPVVLEVDAARMHA-E------------GHAFSVSENGVWLVA-----------AVPPDYLRQRAVPPD  171   Actinosynnema mirum DSM 43827                            bacteria>actinobacteria                     
182437433  468  1     SKYLSKHLRHQ--PER-IGLT--LDEN-GWVAVE--EL--LRAAARH----------GFAFSRAELDHVVAAND-KRRFTVENG--------------------------------------------------------caadgvh-------------------------------------------------------------------------------------------------GDRIRANQGHT--VA----------VDLDL------------------------------PPAEPP---AHLYHGTVARVM-DAIRTEG--LRPMARHHVHLSPDR------------------------ETATRVGARRG-RPLVLTVDAGAMHR-A------------GHVFRVSANGVWLAD-----------AVPPRFLLADAVPPR  185   Streptomyces griseus subsp. griseus NBRC 13350           bacteria>actinobacteria                     
284988800  471  1     SKRLSYVLRHA--PGS-VGLT--LDAA-GWADVD--AL--LAALG---------------WTRAELERVVATND-KRRFALDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------GTRIRASQGHS--VA----------VDLGY------------------------------AAQTPP---PVLFHGTAERNV-PAIEAGG--LRPGRRHAVHLSPDE------------------------VTARRVGARHG-RPVVLRVDAAGMAA-V------------GAVFTRSANGVWLVD-----------AVPPAFLTVVGVPPA  173   Geodermatophilus obscurus DSM 43160                      bacteria>actinobacteria                     
311899069  473  7     SKTLSRILRHD--PGA-VGIT--LDAA-GWVEVD--AL--LAALARH----------GRRLSRAELDHVVATND-KRRFAYSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GRSIRASQGHT--VE----------VDLGL------------------------------PAATPP---DTLFHGTAERTL-RHVLAEG--LRPMSRRDVHLSADT------------------------ETAVKVGSRHG-RPVVLAVDAAAMAR-D------------GYEFRASANGVWLTD-----------AVPVGYLRRTPVPVG  184   Kitasatospora setae KM-6054                              bacteria>actinobacteria                     
296130288  477  5     SRFLSYVLRHR--PDA-AGLT--LDAA-GWVDVD--VL--LAALAAH----------GHTATPEDLRYLAEDVPGKKRLELRD-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-RVRAAQGHS--VR----------VDLGL------------------------------APVVPP---ATLFHGTATRFL-DRILVDG--LRPMSRQHVHLSADR------------------------ATATDVGSRHG-RPVVLLVDAAAMHA-G------------GAAFYRAANGVWLTD-----------AVPPEHLRREVVPPE  172   Cellulomonas flavigena DSM 20109                         bacteria>actinobacteria                     
330469061  478  3     SKFLSYVLRHR--PDA-VGVT--LDEA-GWVPVD--VL--LAALARH----------GRPVTPALLDQLVGNTD-KQRFEVRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-RIRAAQGHT--IA----------VDLQL------------------------------APAVPP---TVLYHGTVARFL-PGIRVEG--LTSGERTHVHLSSDL------------------------DTAARVGARRG-KPVVLRIDAAGMHV-A------------GLVLYRAANGVWLTR-----------HVPPRFITLPSVPPR  178   Verrucosispora maris AB-18-032                           bacteria>actinobacteria                     
159038434  479  5     GKALAYVLRHR--PDA-VGLQ--LDSA-GWVEIP--AL--LSAMADA----------GHTIGEADLDRIVAGSD-KKRYEVRA-----------------------------------------------------------------------------------------------------------------------------------------------------------------R-RIRAAQGHS--VR----------VELGL------------------------------EPTIPP---AVLYHGTVARFL-EAIRREG--LRPGERTHVHLSADA------------------------STARQVGERRG-APVVLEIEAKRMYA-D------------GHSFLLAANGVWLVA-----------HVPPDYLALTDVSPD  175   Salinispora arenicola CNS-205                            bacteria>actinobacteria                     
159901400  482  1     SKYLSKHLRHQ--PER-LGLT--LEPG-GWVGVE--QL--LAACAAN----------NVAISLAELHEVVEQNN-KQRFGFDPT----------------------------------------------------------------------------------------------------------------------------------------------------------------GQKIRAHQGHS--VT----------VDLGL------------------------------VAQQPP---IILYHGTAKHNL-AIILRDG--LRPMQRQHVHLSRDR------------------------ATALQVGARHG-QAVILIVQADELFQ-A------------GQAFFCSDNGVWLTT-----------AIDPAYLALERIDPA  178   Herpetosiphon aurantiacus ATCC 23779                     bacteria>chloroflexi                        
67921554   483  20    SRFLSYHLRHA--PEK-LGLE--LEPG-GWISTE--KL--LKACQNT----------KFTLTFSDLETVVKDND-KQRFSFNEA----------------------------------------------------------------------------------------------------------------------------------------------------------------KTKIRANQGHS--VN----------IDLQL------------------------------EPLIPP---VILYHGTHQKVV-KTILKEG--LKKMARHHVHLSERK------------------------ETALKVGSRRG-KPVIFVIKAQQMSE-D------------GCIFYCSDNGVWLVD-----------YIDPKYLTIKYIDPK  197   Crocosphaera watsonii WH 8501                            bacteria>cyanobacteria                      
300868996  484  1     SKYLSRHLRHT--PER-LGIE--LSPG-GWVAVD--RL--LAASSDR----------NFPIQLAELKEVVAKND-KQRFSFDST----------------------------------------------------------------------------------------------------------------------------------------------------------------GTLIRANQGHS--IT----------VDLQL------------------------------EPAVPP---DVLYHGTGKGAV-ESILKSG--ICKMSRHHVHLSVNI------------------------KTAQKVGARHG-LPVVFTIAAEAMHD-R------------GYTFYCSENGVWLVE-----------YVPPEYLKLTYVPPE  180   Oscillatoria sp. PCC 6506                                bacteria>cyanobacteria                      
307150228  485  1     SKYLSYHLRHH--PEE-LGLE--LAPG-GWVEVE--KL--LAACLEA----------QFPLTREELEEVVTNND-KQRFSFDQT----------------------------------------------------------------------------------------------------------------------------------------------------------------KTLIRANQGHS--VP----------VDLQL------------------------------TSLAPP---EILYHGTSTKAV-PSILSQG--LLKMARHHVHLSTTI------------------------EAARKVGQRQG-KPVVFELDAAAMYQ-A------------GYQFFVSENGVWLVE-----------TVPPAYLRQIYPLLV  178   Cyanothece sp. PCC 7822                                  bacteria>cyanobacteria                      
168698114  489  1     SKFLSKVLRHE--PES-AGLT--LERG-GWVPIV--DL--LSGLARS----------GTRISREDLDVVVSECE-KQRFAIDDT----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--AE----------VELQF------------------------------EPVEPP---TELYDGTTETNI-SSVLRDG--LLKMARHHVHLSADG------------------------TTARKVGGRHG-KPVVITVHAAQMSA-D------------GYIFYRSANGVWLVD-----------HVPPQYLRLDHVPPQ  178   Gemmata obscuriglobus UQM 2246                           bacteria>planctomycetes                     
302868056  490  1     SKRLSLALRHR--PDT-FGLR--LDRA-GWVPVA--DV--LAGLR---------------ISRAQLDAVVAGND-KQRFAVEAGpd-------------------------------------------------------------------------------------------------------------------------------------------------------------gADRIRANQGHS--VP----------VDLGL------------------------------TPAAPP---PRLFHGTGEAVL-DAIRAQG--LRRGGRHHVHLSPDV------------------------ATARRVGARRGGAVVVLTVDAAAMAE-A------------GYLFYRSANGVWLTD-----------TVPPPYLLTDTVPPP  177   Micromonospora aurantiaca ATCC 27029                     bacteria>actinobacteria                     
320333790  491  1     SRRLSYLLRHA--PHE-AGLT--LEPG-GWVRVD--DL--LAGLRRL----------GVAATREAVETVVRTND-KRRFSLDGA----------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRANQGHS--VP----------VDLEL------------------------------TPSVPP---DALYHGTVRAAT-GDIFREG--LRPMARHHVHLSPDT------------------------ATAVRVGARRG-RPVVLRVDAAGMHA-A------------GHRFYCSENGVWLTD-----------TVPPAFLSVLPADGT  177   Deinococcus maricopensis DSM 21211                       bacteria>deinococci                         
226355053  492  1     LSYL---LRHA--PQK-AGLT--LEPG-GWAPLA--PV--LAHLN---------------VTRAQVERVVATNN-KQRFTLN------------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRANQGHS--VE----------VDLRL------------------------------PLTVPP---ARLYHGTHPGVL-AAIQHEG--LRPMQRHHVHLSSDP------------------------ETARQVGARRG-TPVILTVQSGAMYD-A------------GHSFYRSDNGVWLTE-----------AVPPEFLNFPAVPPE  171   Deinococcus deserti VCD115                               bacteria>deinococci                         
325283812  495  1     SKRLAYLLRHA--PHE-AGLT--LARG-GWVPLA--PL--LAHLR---------------VTRGQVERVVREDE-KGRFGLSEG----------------------------------------------------------------------------------------------------------------------------------------------------------------GDKIRATQGHS--VP----------VDLGL------------------------------EPQVPP---ATLYHGSHQGAR-VGITRHG--LKAMSRHHVHLSADT------------------------DTALKVGLRRG-WPLLFAVDAARLHA-D------------GFTFYRSENGVWLVD-----------AVPPAYLSELPTPGQ  170   Deinococcus proteolyticus MRP                            bacteria>deinococci                         
291300690  1    6     SKKLSYVLRHD--PAS-IGVT--VDAA-GWIDID--TL--LAALTRH----------GTTVSRQQLDAVVATND-KQRFTIDA------------------------------------------------------------------------------------------------------------------------------------------------------------------ERIRANQGHS--IT----------VDLGL------------------------------KARVPP---ARLFHGTATTRL-ASILDTG--LRRGTRHHVHLSTDT------------------------ATAAKVGSRHG-IPAVLTIDAAGMHD-H------------GHEFFVSANGVWLVD-----------SVPATYLTAQSVPAT  181   Stackebrandtia nassauensis DSM 44728                     bacteria>actinobacteria                     
258545015  2    12    SKRLSFILRHQ--PQS-IGIT--LDAQ-GWVDVA--IL--LQQLNAH----------GTAIDRALLDHVVATNP-KQRFSYDAS----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIRANQGHS--VA----------IDLAY------------------------------TPCVPP---ETLYHGTARSTF-AAIRESG-GLDKRTRHHVHLSSDV------------------------ETAMKVGQRHG-KPLVLRIAAGEMQR-D------------GHVFYQSDNGVWLTE-----------HVPLAYISADAVPLA  181   Cardiobacterium hominis ATCC 15826                       bacteria>proteobacteria>gammaproteobacteria 
226330224  4    8     SRFLSYILRHA--PES-IGLT--LDDQ-GWGEIS--TL--ISLAQKN----------GTPLTLKLIKDVVETND-KKRFAISED----------------------------------------------------------------------------------------------------------------------------------------------------------------GFFIRAVQGHS--LK----------TTVDY------------------------------QAITPP---KILYHGTATRFI-TSIFDQG--LIPNGRQYVHLSQDY------------------------KTAVNVGNRHG-KAVVLTVDSEKMFS-E------------GFEFYQADNGVWLTL-----------SVPAKYLKIDENEAK  176   Proteus penneri ATCC 35198                               bacteria>proteobacteria>gammaproteobacteria 
225075180  5    3     SKFLSFILRHH--PEQ-IGIT--LDKD-GWVDID--TL--LTQVNHP-----ergftGNPLTYEVLLEVVENND-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRAAQGHS--TA---------QVQVEH------------------------------KVATPP---QILYHGTAERSV-PSIMEQG--LHSASRHFVHLSADA------------------------ATAVNVGSRHG-KPVVLTIDTVAMLA-A------------GHQFYLADNGVWLTE-----------NVPPQFILTENVPPQ  186   Neisseria flavescens NRL30031/H210                       bacteria>proteobacteria>betaproteobacteria  
308446799  6    4     SKFLSLVLRHQ--PET-IAIQ--LDSE-GWTDVH--IL--LQQMIKH----------KRPLKLVELIEVVESSD-KKRFQLSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------QSKIRAVQGHS--SA---------QVQREY------------------------------AAITPP---DTLFHGTATRFV-NSILEKG--LISGERHHVHLSADL------------------------VTAQKVGQRHG-KVIIFILDTKQMHQ-D------------GFRFYCAENGVWLTE-----------QVPIKYLKLFESNQK  183   Caenorhabditis remanei                                   eukaryota>metazoa>nematoda                  
225023628  9    9     SKFLSYILRHH--PEA-IGLT--LDGE-GWADVD--EL--LTQAAAH----------GRNISLPLLHEVVATNN-KKRFTLSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GGKIRAEQGHS--TA---------QVDIAY------------------------------TETEPP---EILYHGTAQRFA-EAIEEQG--LLPGSRHYVHLSGDV------------------------ETAVSVGSRHG-KPLVLEVQAGLMRQ-Q------------GFVFYLTANKVWLIK-----------EVPSQFLRRMEVPSQ  178   Eikenella corrodens ATCC 23834                           bacteria>proteobacteria>betaproteobacteria  
15891357   11   6     SKFLSYVLRHA--PES-IGLV--LDSQ-GWADVA--DL--LAKANAS----------GTPLDEAGLRAVVAESD-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRAAQGHS--VK----------VDLGQ------------------------------PPVEPP---PQLFHGTATRFL-EPILREG--LRPGERQQVHLSADR------------------------TTALAVGQRHG-KPVVLIVDAGQMFA-D------------GCRFYLADNGVWLTD-----------AVPFSYLTVSADSSA  174   Agrobacterium tumefaciens str. C58                       bacteria>proteobacteria>alphaproteobacteria 
213966822  12   1     SKLLSYVLRHA--PES-MGLT--LDRD-GWCEVD--EL--VGKANAN----------GHSFDRQALKEVVETNE-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GQRIRAAQGHS--TR---------LVQVQH------------------------------IEKEPP---ARLYHGTASRFM-ASIETQG--LIAGSRHHVHLTEDP------------------------ETALSVGKRYG-QPVLLAVDAKGMFE-A------------GVQFFQADNGVWLVE-----------AVPIEWLTKVADTVS  179   Pseudomonas syringae pv. tomato T1                       bacteria>proteobacteria>gammaproteobacteria 
32476856   36   4     SKFLSLVLRHQ--PGV-IGMT--LDEQ-GWLEID--GL--IANANTR----------GKKLTLELIHEVVATND-KKRFVLSDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRASQGHS--VA---------GVDLNL------------------------------TEANPP---ATLYHGTVDAFL-PRIREQG--LQKRSRNHVHLSADE------------------------ATATNVGSRRG-KPKLLLIAAQRMHQ-D------------GHIFYLSENEVWLVD-----------SVPPTYLTFPTVPPT  183   Rhodopirellula baltica SH 1                              bacteria>planctomycetes                     
325928686  16   7     SKFLSYVLRHA--PQS-IGLT--LDRE-GWADID--AL--IAAATAA----------GRALDADLIRAVVSSND-KQRFALSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRQIRAVQGHS--TA---------TVALVH------------------------------MPRTPP---SMLYHGTATRFL-EAILAQG--LQPGQRHHVHLSADP------------------------KTATTVGARHG-APSVLRVHSLQMHE-D------------GHVFYQADNGVWLTR-----------HVPPNYLHLVQVPPN  180   Xanthomonas perforans 91-118                             bacteria>proteobacteria>gammaproteobacteria 
170683612  18   5     SKFLSFVLRHK--PES-IGIV--LDRE-GWADID--KL--ILCAQKA----------GKRLTRALLDTVVATSD-KKRFSYSSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRCIRAVQGHS--TS---------QVAISF------------------------------AEKTPP---QFLYHGTASRFL-DEIKKQG--LIAGERHYVHLSADE------------------------ATARKVGARHG-SPVILTVKAQEMAK-R------------GLPFWQAENGVWLTS-----------TVAVEFLEWPFMPAG  185   Escherichia coli SMS-3-5                                 bacteria>proteobacteria>gammaproteobacteria 
260554979  19   1     SQYLSFILRHK--PEE-IGLT--LDRE-GWANIE--EL--ISKSQPV---------kNVALDEEIIKNIVSNSD-KKRFQISDD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKLIRAVQGHS--TT---------SVDITL------------------------------NKLKPP---TYLYHGTAQRFI-DSIKEQG--LISKDRQYVHLTENR------------------------DTALTVGARYG-KPEILVIDALKMHD-S------------GFEFFQAENGVWLSK-----------HVPIEFIAFKHVPIE  179   Acinetobacter baumannii ATCC 19606                       bacteria>proteobacteria>gammaproteobacteria 
330977809  21   1     SKFLSYVLRHE--PEA-IGLE--LSRD-GWADID--ML--IACAAKN----------EQVFDRDFLERVVAESE-KKRFLISED----------------------------------------------------------------------------------------------------------------------------------------------------------------RRYIRAAQGHS--NS---------SVSIQY------------------------------TQVVPP---EFLYHGTATRFL-ESIFKEG--LVAGARHYVHLSESK------------------------ETARSVGLRYG-KPIVLEIEALHMHN-L------------GFKFFQAENNVWLID-----------KVPASWLVLKGVPAS  179   Pseudomonas syringae pv. aptata str. DSM 50252           bacteria>proteobacteria>gammaproteobacteria 
172064765  25   29    SKFLSFVLRHA--PES-IGLQ--LDRE-GWASID--SV--LAGAITQ----------PFTLNREILHIVVSESD-KKRFEISAD----------------------------------------------------------------------------------------------------------------------------------------------------------------DQWIRAVQGHT--SS---------SVRREY------------------------------VEKQPP---EFLYHGTVERFL-DSILEQG--LHQGTRHHVHLSASI------------------------ETAISVGKRRG-KPVVLKIDSSRMYR-Q------------GFKFFLTENGVWLTG-----------AVPVDFIEILTVPVD  208   Burkholderia ambifaria MC40-6                            bacteria>proteobacteria>betaproteobacteria  
322832748  27   1     SKFLSYILRHK--PDT-IGLQ--LDVE-GWADIN--SL--ILGAAKE----------GRVLDQAIIQTVVNSSD-KKRFTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GQRIRAVQGHS--TP---------DVNLQH------------------------------MEKKPP---EFLYHGTATRFL-ESILQQG--LIAGSRHHVHLSQDI------------------------TTAVAVGQRYG-KPAVLKVEALRMHQ-Q------------GFNFFQAENGVWLTN-----------HVPNFFIYQEHVPNF  179   Rahnella sp. Y9602                                       bacteria>proteobacteria>gammaproteobacteria 
107099046  29   1     SKFLSYVLRHQ--PEA-IGLT--LDGE-GWADID--AL--IAGAARD----------GRALDRVLLGAVVENND-KKRFALSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------DQRIRAVQGHS--HA---------AVAIAY------------------------------APAVPP---AVLYHGTASRFL-DSIRERG--LVPGSRHHVHLSARR------------------------ATALEVGRRYG-SPVLLEIDARDMHL-A------------GHLFHQAENGVWLTE-----------RVPVRFIREARVPVR  179   Pseudomonas aeruginosa PACS2                             bacteria>proteobacteria>gammaproteobacteria 
70733133   30   1     SKFLSYVLRHE--PQA-IGLE--LDSE-GWGDID--AL--ISGAAKN----------GRQLSRELIELVVEGND-KKRFALSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------SRRIRAVQGHS--NK---------AVQLQL------------------------------EAKQPP---AVLFHGTATRFM-DSINEKG--LIPGSRHHVHLSQEI------------------------DTARAVGQRYG-KVVILQIDAQAMQA-Q------------GFTFYQAENGVWLTD-----------QVPVGFIKALQVPVG  179   Pseudomonas fluorescens Pf-5                             bacteria>proteobacteria>gammaproteobacteria 
53718401   35   10    SKFLSYVLRHR--PDS-IGVT--LDAQ-GWADVS--EL--LTKAAAA----------GMALTLDELKQVVAEND-KKRFVLNDD----------------------------------------------------------------------------------------------------------------------------------------------------------------ATRIRAAQGHS--VD----------VDLQL------------------------------PVKAPP---PVLYHGTVGKSM-ADIRKQG--LTPMNRHDVHLSPDR------------------------ETATRVATRRG-KPVILVIETYPLLR-D------------GYQFRVSDNGVWLVP-----------EVPAKYIKFPGVPAK  183   Burkholderia pseudomallei K96243                         bacteria>proteobacteria>betaproteobacteria  
307946056  39   6     SKFLSYVLRHK--PEA-IGLS--MDEA-GWVAID--EI--LEKAN-------------RPISRELIEQIVAEND-KQRFAISSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRQLRANQGHS--VS----------VDLKL------------------------------KPKEPP---AELFHGTASRFL-DSIFEKG--LVPGTRQHVHLSANV------------------------ETALKVGQRHG-KPVILAVPALEMHQ-S------------GHFFFLSENGVWLTH-----------AVPANKLVLHDNNAN  176   Roseibium sp. TrichSKD4                                  bacteria>proteobacteria>alphaproteobacteria 
329847506  41   1     SKFLSLVLRHQ--PET-IGLT--LDAH-GWTSVD--DL--LKRMAAH----------GKFLTREKLERVVAEND-KKRYTLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRAAQGHS--VK----------VDLAL------------------------------LPALPP---DILYHGTATRFV-ESIMTEG--LKPQSRQQVHLSLDY------------------------ATASKVGQRHG-KPYIFRVEAGRMQA-D------------GHLFFRADNGVWLTD-----------AVPPQYLIAPDSAAQ  178   Asticcacaulis biprosthecum C19                           bacteria>proteobacteria>alphaproteobacteria 
296114887  43   15    SKFLSLVLRHA--PER-IAIS--LDPQ-GWVETT--IL--IRQARRH----------GQTFDLPSLQRVVRDND-KQRFTLSPD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKRIRAAQGHS--IA----------VDLAL------------------------------PPAIPP---AVLWHGTARTSL-ESIFRDG--LLPGRRRHVHLSNDE------------------------ATAMTVGTRHG-RAVVMRVAAGRMHD-D------------GLTLWRADNGVWLTD-----------GVPPCYLSFAGVPPC  188   Gluconacetobacter hansenii ATCC 23769                    bacteria>proteobacteria>alphaproteobacteria 
84499293   45   1     ------------------------------------------------------------MSRGHLVRLVADDN-KRRFTLSEG----------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRAAQGHS--LA----------VDLTL------------------------------APQSPP---AVLYHGTNRQSL-DSIFQSG--LLSGRRQFVHLSADV------------------------DTALDVGTRHG-KPIVLSVEAGAMSR-G------------GHQFWVADNGVWLTR-----------QVPAQFLAFAPRHDP  131   Oceanicola batsensis HTCC2597                            bacteria>proteobacteria>alphaproteobacteria 
84499284   42   1     SKFLSRVLRHE--PEL-IAIQ--LDPQ-GWVSVD--DL--LRRLKKV----------GHGMSREQLREIVETND-KRRFTLSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GRRIRAAQGHS--VD----------VDLGL------------------------------TPLVPP---EFLYHGTAAQNL-DAIFETG--LNPGRRRQVHLSPEP------------------------ETANRVGQRHG-KPTVLRVEASKMHA-D------------GFVFTCSDNGVWLTD-----------SVPAAYLGFGVMLAA  175   Oceanicola batsensis HTCC2597                            bacteria>proteobacteria>alphaproteobacteria 
84501233   44   1     SRFLSLILRHK--PEE-VGLK--LGPG-GWVRID--EL--LVAMKRA----------GRRLTRDHLIEIVEQND-KKRFTISSD----------------------------------------------------------------------------------------------------------------------------------------------------------------GERIRAAQGHS--LD----------VDLGL------------------------------PAQDPP---DELFHGTARAHL-DEIFSAG--IIPGRRRLVHLSVDI------------------------ATALTVGGRHG-KPVVLTVAAKAMHQ-D------------GHKFYRADNGVWLTD-----------HVPTSYLSFATIRTS  175   Oceanicola batsensis HTCC2597                            bacteria>proteobacteria>alphaproteobacteria 
221067794  50   35    SKFLSLVLRHS--PET-IGLT--LDEA-GWARTD--EL--LACLARS----------GRPTRLEELQRIVADNN-KQRYSFSAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GKHIRANQGHS--IK----------VELGL------------------------------EASSPP---AVLYHGTATRFL-DAIFHEG--LNRQSRHHVHLSDSV------------------------EVAAQVGSRHG-KLALLQVDAARMQG-E------------GHVFYRSDNGVWLTD-----------VVPVRYLLKLPSPVR  212   Comamonas testosteroni KF-1                              bacteria>proteobacteria>betaproteobacteria  
333912499  51   3     SKFMSLVLRHN--PGR-AGLA--LDAQ-GWVSID--AL--LRGAQAA----------GRNISPALLMEVVRSCP-KQRFAISAD----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRASQGHS--VQ----------IDLGL------------------------------QASVPP---QRLYHGTATRFL-DSILRTG--LDRRNRHHVHLTDNL------------------------ATARSVGQRYG-RLVLLEIDAARMHA-D------------ACLFYRSDNGVWLTD-----------SVAPHYLRVLAEEEH  179   Delftia sp. Cs1-4                                        bacteria>proteobacteria>betaproteobacteria  
158337724  53   2     SKFLSYILRHR--PEA-ISLE--LNAG-GWAAIS--EL--IQCASKH----------DHFLSEEIIKEVVVSND-KKRFKLSED----------------------------------------------------------------------------------------------------------------------------------------------------------------GQYIRANQGHS--IR----------VDLDL------------------------------LPLTPP---DVLFHGTATRFL-ASIMAKG--LLPSGRQHVHLSASY------------------------ETAIAVGRRHG-KPTVLEINAQKMQG-D------------GYLFYRSENGVWLTD-----------HVPAQYFVEVEVPAQ  177   Acaryochloris marina MBIC11017                           bacteria>cyanobacteria                      
330983843  54   95    GRYLAAILRHKKISDN-IGLK--HDAQ-GWMSIA--DI--IEKSTAN--------rkAPPLSVEIIDLAVQHCD-KQRYAISPD----------------------------------------------------------------------------------------------------------------------------------------------------------------RCHIRAKQGHS--FP----------VDLGL------------------------------KAEIPP---VVLYHGTVDRFF-SSIMREG--LTPQKRQHVHLSHEKe-----------------------TALNVGGRRKG-EVIILEIDAKAMLA-N------------GHVFHLSENGVWLTE-----------AVPSQYINTEAVPSQ  277   Pseudomonas syringae pv. lachrymans str. M301315         bacteria>proteobacteria>gammaproteobacteria 
34497880   58   35    SRFLSLVLRHQ--PET-IGLQ--LDDQ-GWADIG--EL--LARLAAK----------GRNLGRKQLEKIVLDND-KQRFAISED----------------------------------------------------------------------------------------------------------------------------------------------------------------GLRIRANQGHS--IK----------IDLGL------------------------------AACEPP---DRLYHGTASRFL-DAILAEG--LRPGQRQHVHLSADG------------------------QTARKVGARHG-KPVVLEIDARAMRQ-A------------GLAFYRSDNGVWLID-----------GVPPVFIRQTEARPV  203   Chromobacterium violaceum ATCC 12472                     bacteria>proteobacteria>betaproteobacteria  
83643039   59   15    SKFLSLVLRHQ--PEL-IQLP--LDAN-GWADIE--VL--LAGAARQ----------GVNISLQDVLEIVATND-KQRFALSGD----------------------------------------------------------------------------------------------------------------------------------------------------------------KRRIRASQGHS--ID----------VDLQL------------------------------TPVTPP---DELYHGSATRFT-DAILATG--LQPGQRRHVHLSADV------------------------ETAHKVGSRHG-KPVIFRIDAKALTL-A------------GHAFYLSANQVWLTD-----------AVPPQYLSLLDTSPQ  179   Hahella chejuensis KCTC 2396                             bacteria>proteobacteria>gammaproteobacteria 
325189229  64   17    SKKLSYALRHG--ALD-LKLD--MTTD-GYVDTS--HL--LAKSMFA------------SYTISDIERVVETND-KKRYEMRRD--------------------------------------------------------------------------------------------------------------------------------------------------------------geGKFIRATQGHS--LK--------IVNDEHLL--ALVS-----------------------DANEI----EHCIHGTLEQNW-TQIENSG--LSSMKRNHIHFTTQEf-----------------------GAQVISGMKQT-SELMVYINIRQAMQ-H------------GIKFYRSSNNVLLTRGIND-----SGTLPVRYVDSGTLPVR  198   Albugo laibachii Nc14                                    eukaryota>stramenopiles                     
254578506  68   9     SKSLSYLLRHG--ALK-EKLP--IDAN-GYVPLQ--VL--LAHNRLK----------SHRCTLEDVHRIVDSNE-KKRFHTKVSs-------------------------------------------------------------------------------------------------------------------------------------------------------------egQELICATQGHS--IK-------SVLPTEDVL--HEIR-----------------------DPKELP---PKLVHGTTVHNA-LLILQSG-AIKKLRRNHVHLSPGVtgv---------------------DAAVVSGMRAT-SNVHIYIKLGSELL-E------------QMKVYKSLNNVYLVP----------DDVPIALFDPDDVPIA  194   Zygosaccharomyces rouxii CBS 732                         eukaryota>fungi>ascomycota                  
45198857   69   14    SKSLSYLLRHG--ALK-EQLP--IDSD-GYVPVS--AV--LAHNRLK----------SHRCSFSDLQRIVENNE-KKRFHMRPGp-------------------------------------------------------------------------------------------------------------------------------------------------------------dgQEYICATQGHT--IE-------QVLPSADVL--TQLI-----------------------DPGELP---AQLIHGTNLRNA-VLILDSG-CIKRMQRNHVHLSHGVtg----------------------KDCVISGMRLS-STVHIYLNTE-GIL-D------------HLRLYKSRNDVYLTP----------SDIPVVYLTPSDIPVS  193   Ashbya gossypii ATCC 10895                               eukaryota>fungi>ascomycota                  
255712699  71   11    SKSLAYLLRHG--ALK-EKLP--IDPN-GYIPIS--VL--LQHNRLK----------SLHCTQQDVDRVVANNA-KKRFHIKTE--------------------------------------------------------------------------------------------------------------------------------------------------------------dnNVLICATQGHS--IA-------AVAPAGDVL--QPIT-----------------------ADDKLP---EKLVHGTNLKNC-KLIIESG-GIRKMRRNHVHLAAGItgl---------------------DGEVVSGTRTS-SNVFIFLKRE-LAF-Q------------QLRLFKSLNDVYLTA----------DDVPTELFEADDVPTE  194   Lachancea thermotolerans CBS 6340                        eukaryota>fungi>ascomycota                  
50305581   72   15    SKALAYLLRHG--AVK-ENLP--IDSD-GYIALD--RI--LQHNRLK----------SLKATSTEIQHIVASND-KQRFHIKTDpn------------------------------------------------------------------------------------------------------------------------------------------------------------tgIMYVCATQGHT--LK-------QIAPSQHVL--KPIT-----------------------NIEQLS---SKLVHGTNVSNC-ISILHSG-FIKKMSRNHVHLSPGItgk---------------------DTDVISGMRSS-SNVYIHIKRIQEML-D------------SLNLVKSLNNVYLTS----------QDIPLKFIDFQDIPLK  204   Kluyveromyces lactis NRRL Y-1140                         eukaryota>fungi>ascomycota                  
151945531  75   15    SKALSYLLRHA--AVK-EKLT--IDSN-GYTPLK--EL--LSHNRLK----------THKCTVDDIHRIVKEND-KQRFHIKTLga-------------------------------------------------------------------------------------------------------------------------------------------------------------dEEWICATQGHS--IK-------SIQPSDEVL--VPIT-----------------------EASQLP---QELIHGTNLQSV-IKIIESG-AISPMSRNHVHLSPGMlh----------------------AKGVISGMRSS-SNVYIFIDCHSPLFFH------------TLKMFRSLNNVYLSS-----------SIPVELILSSSIPVE  198   Saccharomyces cerevisiae YJM789                          eukaryota>fungi>ascomycota                  
126131670  84   1     SKAMSYLLRHA--AVK-EKLA--IDED-GYVQIE--DL--LKHQRLK----------TFRTSIADLERVVQNDN-KQRYTIK------------------------------------------------------------------------------------------------------------------------------------------------------------------DNAICANQGHS--IK---------SVGSDNL--ELLT------------------------LETIP---SEVYHGTYRNKL-GLIYSSG-GLNRLRRNHIHMTSK-------------------------AYSVKSGIRYN-ANVLIYIDVAKCME-A------------GIKFYKSLNDVILSEGDEN------GYISWKYFDKVVEVKT  188   Scheffersomyces stipitis CBS 6054                        eukaryota>fungi>ascomycota                  
156845856  76   3     SKALSYLLRHG--AQK-EKLS--INSN-GYILVK--DI--LSHNRLK----------THKCTLEDLHRIVENND-KKRFHLKIV--------------------------------------------------------------------------------------------------------------------------------------------------------------ddQEHICATQGHS--LK-------TVKPSDEVL--EPVL-----------------------SLDQLP---KRLVHGTNLQNA-ILIFKSG-QIKKMNRNHVHLSPGVige---------------------DSEVVSGMRYS-SNVHIFLKLNDSLL-E------------NLKLFKSINSVYLSA----------VDIPTDLVEAVDIPTD  201   Vanderwaltozyma polyspora DSM 70294                      eukaryota>fungi>ascomycota                  
241952517  83   14    SKALSYLLRHG--AEK-EKLS--IDEQ-GYVKIS--DV--LSHQRLK----------SLKTTIEDIERIVREND-KKRFTIR------------------------------------------------------------------------------------------------------------------------------------------------------------------DEMICANQGHS--LK---------AVKNDNL--VPMT-----------------------IDELNQ---LRIYHGTYKTKL-PIIKSSG-GLSRMNRNHIHLTCD-------------------------QYATCSGIRYN-ANVLVYIDASKCIE-H------------GIVFYKSLNNVILTSGDKD------GKISWEFIDRIVDLEG  192   Candida dubliniensis CD36                                eukaryota>fungi>ascomycota                  
260945038  87   36    SKALSYLLRHG--ADK-EKLP--LDEH-GWAKVS--DV--LANNRIR----------THRATQEDIRRIVAQNA-KQRFTLRER--------------------------------------------------------------------------------------------------------------------------------------------------------------sdGDYICANQGHS--LE---------RVCPEL---ELLT------------------------SETMP---REVYHGTYENKL-DTIMQHG--LNRMARNHIHLACN-------------------------EPWSRSGSRAS-STVFIYIDIDKCLS-A------------GISFYRSKNGVILTSGNAQ------GCIPSEYFAQGCIPSE  214   Clavispora lusitaniae ATCC 42720                         eukaryota>fungi>ascomycota                  
255638634  99   101   SRLLTRILRHM--ASE-LNLN--MRSD-GYVKVN--DL--LKLNLKT-----fanipLRSHTIDHIREAVRKDN-KQRFSLLEE--------------------------------------------------------------------------------------------------------------------------------------------------------------ngELLIRANQGHT--VK--------VVETESLL--KPIL-----------------------SAKEFP----VCLHGTYRKNL-ESILGSG--LKRMKRLHVHFSCGLpt----------------------DGEVISGMRQD-VNVLIFLDVRKALE-E------------SIKLYISDNKVILTEGFD-------GVVPPKYFEDGVVPPK  289   Glycine max                                              eukaryota>viridiplantae                     
148907021  100  374   -RSLSSVLRHR--ADE-LKLN--IRSD-GYVAVK--DL--LKLNVKT-----parvpLNSHSIDDIKEAVKRDN-KQRFGLLEE--------------------------------------------------------------------------------------------------------------------------------------------------------------ksVLLIRANQGHS--IN--------FIDSEELL--KPIL-----------------------SAEDVP----VCVHGTYLKNL-ELIKKNG--LNRMKRNHVHFARGLsk----------------------DSGVISGMRSD-CEVFIYLDTKKALQ-G------------GMKLFVSENGVILTEGFN-------GVVPPEYFFNGVVPPE  560   Picea sitchensis                                         eukaryota>viridiplantae                     
168049051  102  9     -RCMTAILRHR--ASD-YGLE--MQND-GFVLVA--DL--LKLSKNT-----aagipLSSHSVEDVRKAVARDG-KRRFGLKEE--------------------------------------------------------------------------------------------------------------------------------------------------------------dgHLYIRANQGHS--IR--------TVESGQLL--SLVT-----------------------SPSQIP----VCVHGTYERFM-DSIWQEG--LKRMNRNHVHFATGLpe----------------------QDGVISGMRGS-AQVLIYLDVEKAME-D------------GMKLYVSDNKVVLTEGFD-------GVVPTKYFFDGVVPTK  195   Physcomitrella patens subsp. patens                      eukaryota>viridiplantae                     
302766619  103  36    -RALTKILRHR--AAE-LNLE--MRSD-GFCKVA--DL--LRLDFTT-----rskvpLSAHTVEEVLQAVEQNS-KERLATMVDe-------------------------------------------------------------------------------------------------------------------------------------------------------------sgELLIRANQGHT--LL-------DAVCSDDLL--EEIS-----------------------IDDNML---AVCVHGTFKHAL-PGILRDG--LKTMGRKHVHFAAGLpg----------------------AGEVVSGMRGS-CDALVFVNAARAMA-D------------GMKFYVSKNGVVLTEGFE-------QCVPAKYFDEQCVPAK  226   Selaginella moellendorffii                               eukaryota>viridiplantae                     
302756333  104  15    -RAMTKILRHE--AAT-FNLD--LRSD-GYCKVD--EL--LKIGMKT-----ragipLSSHSVEEVLQAVKQDN-KQRFSTTRE--------------------------------------------------------------------------------------------------------------------------------------------------------------dgTLYIRANQGHS--IK--------EVLSDHLL--REIS-----------------------STDKIP----VCIHGTYKHAL-PSILESG--LKVMGRNHVHFATGLpd----------------------ENGVISGMRSS-CQVLIYLDTEKAMA-D------------GMKFYVSDNNVVLTEGFE-------GCVPCEYFEEGCVPCE  202   Selaginella moellendorffii                               eukaryota>viridiplantae                     
302757341  106  13    ---LCRILRHQ--ATQ-LSLP--IRSN-GYVKVD--DI--LRLTIRT-----hagipMNEHSVEEVLRVVERDP-KQRYSTMVE--------------------------------------------------------------------------------------------------------------------------------------------------------------ggELFIRANQGHS--MK--------VVASDALL--TEIT-----------------------SADQVP----VCVHGTFRCFL-PSIMRTG--LNRMSRNHVHFAIGLpn----------------------EEGVISGMMDS-VEVLIYLNVAKALQ-D------------DMKLYISDNKVLLTEGFA-------GVVPCEYFEAGVVPCE  198   Selaginella moellendorffii                               eukaryota>viridiplantae                     
302796097  107  2     SKTIAWVLRHG--AVK-MDLK--IRSN-GYCSIK--DL--LEMDVKI-----gggipLSSFTVADVMSMVACDP-KQRFSTIEEe-------------------------------------------------------------------------------------------------------------------------------------------------------------ddQLYIRANQGHT--MD--------AVQTAELL--REIK-----------------------SADEVP----MCVHGTFRNNF-RGIRKTG--LKRMKRNHVHFATGLp-----------------------QDGVISGMKSK-CEVLIYLDLAKAMK-D------------GMKFFMSENGVVLTEGFD-------GVVPREYFEDGVVPRE  195   Selaginella moellendorffii                               eukaryota>viridiplantae                     
302782377  108  2     ------ILRHQ--AVE-MGLK--IRSD-GYCRMN--DL--LKLQPMR------------GHSIQDVLKVVETDL-KTRFSTNVE--------------------------------------------------------------------------------------------------------------------------------------------------------------ngILFIRANQGHS--MK--------AVVTEKLL--KEIE-----------------------SADQVPGTSKVCVHGTFKKNL-ASIRRTG--LCVMGRNHVHFATGLpr----------------------DDGVVSGMRNT-CDALIFLDVEKALD-D------------GMQLFISENRVVLTEGFG-------GVVPPRYGFGGVVPPR  179   Selaginella moellendorffii                               eukaryota>viridiplantae                     
290988948  114  32    SRALSKLLRHK--ADKTKGIN--LRAD-GYVLIR--EI--LALKDFK------------GVTQQMIEECVKNND-KQRFNMTQDat------------------------------------------------------------------------------------------------------------------------------------------------------------tgEYIIRANQGHT--IA-------VEVEMEEI---DSPS-----------------------KLGEYA---NTVMHGTYHDAY-DKIVQSG-GLSRMSRQHIHFAIGEpe----------------------EGHVISGMRKS-AEVCFFLDVQKTID-E------------GIKLLKSSNGVILSLKSSN------GVILSPGNDKGLIPMH  210   Naegleria gruberi strain NEG-M                           eukaryota>heterolobosea                     
322505025  115  365   SKFMSALLRHK--AVQ-WRVP--ITSN-GYVLLD--DV--LRQPQMR---------rKPQVSVQDVARMVRDSD-KQRFQLAYGaa------------------------------------------------------------------------------------------------------------------------------------------------------------dgRLYITATQGHS--ID---------GVEPKL---RTLT-----------------------SVEEVP----MAIHGTYWEAW-KTIQRCG-YLSAMTRQHIHFAKGLmn----------------------DAQVISGMRNN-VQLFIYLDVAAVLA-D------------GVALYESTNGVILTPGVG-----DTRQLPLKYVDTRQLPLK  560   Leishmania braziliensis MHOM/BR/75/M2904                 eukaryota>euglenozoa>kinetoplastida         
261334507  116  333   SKALSRILRHG--ADK-MKIT--ISDA-GYVLAD--DL--VRCAPFS----------NDKAALTHLAWVVYSND-KKRFKMAYDe-------------------------------------------------------------------------------------------------------------------------------------------------------------nrRVYIRANQGHS--LS---------GINPEL---VPIT-----------------------SETQVP----FAVHGTYYSAW-ERIRGCG-YLSTMGRQHIHFAKGMpg----------------------SDGVISGMRNT-SEVLLVLDVPLLLK-E------------SVELWESANGVLLTRGVS-----GTGRLPLKYIGTGRLPLK  526   Trypanosoma brucei gambiense DAL972                      eukaryota>euglenozoa>kinetoplastida         
322815443  117  372   SKTLTRILRHA--ADK-MGIP--VSSG-GFVHVD--HI--LRCKPFC----------NDPLALSHIALVVHTND-KKRFKMAYDd-------------------------------------------------------------------------------------------------------------------------------------------------------------qhRLYIRANQGHS--LA---------GIDPEL---RRIE-----------------------SATEMP----AAIHGTYYSAW-KEICACG-YLSTMTRQHIHFSRGLis----------------------DHCVISGMRSN-VEVLLYLDVAKVLA-D------------GIELWESENGVLLTPGMG-----STKRLPLTYISTKRLPLT  564   Trypanosoma cruzi                                        eukaryota>euglenozoa>kinetoplastida         
328867666  123  5     SKAMSYILRHG--CAK-ERIE--ISAD-GYVKVN--DL--LKNKNFK------------NITFQDIQHVVDTND-KKRFELKQQ--------------------------------------------------------------------------------------------------------------------------------------------------------------dnEYYIRASQGHT--IK--------TVTENDSLF-TKIT-----------------------DINQVP----GVIHGTYRKHL-VSIKEKG--LNKMDRNHIHFATGD------------------------HGDVVSGMRGN-CEIVIYIDLEKALN-D------------GIEFLLSKNGVVLCAGIQ------ TEHVLCAGIQTEHGNHY 188   Dictyostelium fasciculatum                               eukaryota>amoebozoa>mycetozoa>dictyosteliida
281203700  124  9     SKTLSYLLRHG--AVK-EGLT--ISND-GFVKVN--DV--LNHKQMR------------GVTLEKLREIVDTND-KKRYHLEEI--------------------------------------------------------------------------------------------------------------------------------------------------------------ggVLNIRANQGHT--LK--------HVDDVDL---KKIE-----------------------SVNDVP----SVIHGTYRKHL-ESIKSKG--LNKMDRNHIHFATGD------------------------HGDVVSGMRGN-CELVIHINLQKALD-D------------GIPFFLSKNGVVLCAGDKN------GYLLCAGDKNGYLSPI  182   Polysphondylium pallidum PN500                           eukaryota>amoebozoa>mycetozoa>dictyosteliida
330795375  126  10    SKTLSYILRHS--AVK-EGLN--ISKD-GYVSVD--EL--LKHKLFS------------QYTFKDIQEVVDTND-KKRYNLKKGege----------------------------------------------------------------------------------------------------------------------------------------------------------nseKYFICANQGHS--IS--------DVDEVDL---KRIE-----------------------SVDEVE----SVVHGTYKKHL-KSILENG--LQKMERNHIHFAVGLpg----------------------EGQVISGMRGS-CDMVIYIDLQKCLD-D------------DIPMFLSKNNVVLTNGKDNN-----GILPIKYDNNGILPIK  202   Dictyostelium purpureum                                  eukaryota>amoebozoa>mycetozoa>dictyosteliida
238496189  147  18    SKALSLLLRHA--AEK-EGLK--LDAQ-GYANVA--DV--LAWRKLK----------SLKVTFPEIVAAVATSD-KKRFALLHIpst----------------------------------eaqa-------------qqstsaeastehgipttsagqdsatetalavsesd-------------------------------------------------------------------ldpaHFLIRATQGHS--IK---------SVDAASLMEKLSL----------------------dEEAKLP---DTVVHGTFHAAW-PAILASG-GLKSMGRNQVHFATGPsvesvlaqgaqgskevtgdh----GEKVISGMRRD-AQVLIYIDLKKALA-A------------GCPFWRSENGVILSEGMVVE--GSSGIVPVEFFDSGIVPVE  272   Aspergillus flavus NRRL3357                              eukaryota>fungi>ascomycota                  
149246000  82   23    SKALSYLLRHG--AEK-ENLA--IDNL-GYVPIV--QI--LQHQRLK----------SFKTTREDIERIVAEND-KQRFSINAE----------------------------------------------------------------------------------------------------------------------------------------------------------------EDTICANQGHS--LS---------SVSGTL---DLLT-----------------------KAQLAE---MAIYHGTYKKKL-PLILGSG-GLSRMNRNHIHFTCE-------------------------QYHTISGIRNS-ANCLIYIDTDKCID-Ey-----------GLQFFKSANNVILCAGNEHGVIPVDCFAKVVDLKGQPVKVV  189   Lodderomyces elongisporus NRRL YB-4239                   eukaryota>fungi>ascomycota                  
254573246  80   8     SKALSWLLRHG--AQS-EKLT--IDKD-GFVPLE--EV--LNHRRIK----------GTRASFEDVQRIVDNND-KKRFTLQKR--------------------------------------------------------------------------------------------------------------------------------------------------------------ddRWFICANQGHS--IA---------NVNGHDL--KLLS-----------------------TREDLP---KEIIHGTYLSKI-PQIIASG-GLSKMTRNHVHFASGLpkv---------------------DSDVISGMRNG-CSALIYLDIDKILG-Qq-----------EIKFYISKNKVILSYISKNKVILSPGNKDGIVPTSLFLKVV  181   Pichia pastoris GS115                                    eukaryota>fungi>ascomycota                  
294657248  81   14    SKSLSYLLRHG--AVK-EKLN--IDQT-GYININ--EL--LNHNRLK----------TNKVTLDDIRRIVGNND-KKRFSIVEK--------------------------------------------------------------------------------------------------------------------------------------------------------------egEIMICANQGHS--IK---------TVNDSNL--IQLS------------------------KDTIP---EEIYHGTYKNKL-PAIFNSG-GLSKMNRNHIHFASSI--------------------------SDVSGIRNS-SNVLIYLNIEKCLQ-S------------GIVFYRSSNNVILTYRSSNNVILTSGDANGLIGSEFFGKVV  180   Debaryomyces hansenii CBS767                             eukaryota>fungi>ascomycota                  
50290283   67   10    SKALSYLLRHG--AVK-ENLP--FDVN-GYIEVE--RV--LNHQRLK----------SHKCTLEDLHRVVDTND-KKRFNIKLS------------------------------------------------------------------------------------------------------------------------------------------------------------ddgqTELICAVQGHS--ID-------RIKPDEEVL--EVID-----------------------TAEKLP---KNIIHGTSVRNA-IQILKSG-SIKRMNRNHIHLSIGItek---------------------DKEVISGMRKS-SRVHIYILSEPKIL-E------------HLKLYRSMNSVILTYRSMNSVILTPDDINKSLFLLVKIRAA  186   Candida glabrata CBS 138                                 eukaryota>fungi>ascomycota                  
146417847  90   8     SKALSYFLRHG--AQK-SNLE--IDDR-GFIKVA--DL--LAHQNLK----------SKKTTLQDILRVVETNE-KKRFALEDR--------------------------------------------------------------------------------------------------------------------------------------------------------------ngELYICATQGHL--IH---------TVTEGNL--RPL------------------------DEASLP---KQIIHGTRKRAL-EQIRKSG-GLSKMGRNHIHCTSDH--------------------------NLVSGFRST-SDTLIYIDGVQCLR-D------------GIKFFQSSNGVILSFQSSNGVILSPGNDQGVIECKYFAKVT  174   Meyerozyma guilliermondii ATCC 6260                      eukaryota>fungi>ascomycota                  
328769603  94   6     SKALSYLLRHG--AEK-ERLV--IESD-GFVKLK--DI--LSRKQFS------------GQTLESIQHLVESNA-KQRFALRQDpt------------------------------------------------------------------------------------------------------------------------------------------------------------tlQWSIRANQGHS--IN----------VNVEM---RTVQ-----------------------DSSEIP----LVVHGTYQQHL-ALILKQG--LRSMSRKHIHFAAGLpe----------------------HQDITSGMRNN-CNILIYVNTEKAMK-D------------GIVFVQSANNVILTEGVANNVILTEGVDGVLHPRYFSKITD  184   Batrachochytrium dendrobatidis JAM81                     eukaryota>fungi>chytridiomycota             
167377905  95   11    SKRLSYLLRHG--AIK-ERIP--ITKD-GWVLIK--DL--LNNRQMK------------GISEEEIKSIVAKDP-KKRYSIQGE--------------------------------------------------------------------------------------------------------------------------------------------------------------gnQIKIRANQGHS--IN----------VQVEM---KEIT-----------------------DASLYP----IVIHGTYMRNF-NSIIKNG--LQKMGRLHIHMAQGLpke---------------------IKEEKSGMRSS-CNIIIYIDIEKAMK-K------------GIKFYESENGVILSEGPIDISCFSEGPIDIS----------  186   Entamoeba dispar SAW760                                  eukaryota>amoebozoa>entamoebidae            
242785264  145  17    SKALSHLLRHS--AEK-ENLK--ISKE-GYVNVA--DL--LETRKVK----------SLKVTLPEIIQAVASSD-KQRFSLFYIspa----------------------------------tiesg------------nqesqeqqeavvataaseekqknatahalsvkd---------------------------------------------------------------------ndpsHFLIRATQGHS--MK---------SVDTTLFLEKLSL----------------ddtkedgAASNLP---DTVVHGTYHGAW-PLILASG-GLRSMSRLQVHFATGPtmdevypngrdapialldprs---KATVISGMRSD-AEILIYINLRRALE-A------------GCPFYRSENGVILSEGMNLGDSGEGKIVPIEFFDLKIVPIE  280   Talaromyces stipitatus ATCC 10500                        eukaryota>fungi>ascomycota                  
119498195  146  20    SKALSLLLRHA--AEK-EGLK--MDSQ-GYANVA--DV--LAWKKLK----------SLKVTLPEIIHAVASSD-KKRFALLHIpsa----------------------------------kalgdktttgaregetpvcetepssmptsqvpttsagqenatatalavnd---------------------------------------------------------------------tdpsHFLIRATQGHS--IK---------SVDAAAFLERLTL----------------------eDESRLP---DTVVHGTYHAVW-PAILQSG-GLRCMGRNQVHFATGPslesvlpahvdgtahsamgssglnDGRVISGMRRD-AQILIYIDIKKAMA-A------------GCPFWRSENGVILSEGVDVGVILSEGVDVGENQEVGDGTSQ  276   Neosartorya fischeri NRRL 181                            eukaryota>fungi>ascomycota                  
225682414  150  26    SKALSYILRHA--AEK-EGVK--IDSH-GYANVA--DV--LAWRKLK----------SLKVTLPEILSAVSTSD-KQRFGLLYEpls----------------------------------nspsatai----------ptdcsa----------stasrtataqaltand---------------------------------------------------------------------pepsHYLIRATQGHS--IK---------TVEASSLLQRLSLt---------------dgadaapSTPPLP---DTVVHGTYHGAW-PSILVSG-GLKCMNRNHVHFATGPplssvlpegreghvvtmapg----RGGVISGMRAD-AQILIYIDLKKALE-A------------GVPFWRSENGVILSEGLDMDVILSEGLDMDGDGRKIVGLEF  266   Paracoccidioides brasiliensis Pb03                       eukaryota>fungi>ascomycota                  
296825168  154  19    SRELTFILRHA--AEK-EGIK--IDRQ-GYANVG--EL--LQYRKLK----------GLKATLADVLEAVSTSD-KQRFGLLYIpdq----------------------------------pslpeinake------------------eaatgdesslltatnqalaand---------------------------------------------------------------------pdpnNYLIRARQGHS--MK---------CIDSASLLTPLTLs--------------------enPSVPLP---ETVVHGTYHATW-PKILQSG-GLRCMGRNHIHFASGPpissvlpngrggevatppakshg-RDSVISGMRAD-AQILIYIDLKRALA-A------------GCPFGISENGVILSEGIENGVILSEGISSDGTDDKKIGLEF  262   Arthroderma otae CBS 113480                              eukaryota>fungi>ascomycota                  
66807493   127  19    SKSLSYVLRHG--AEK-EGLK--IDSQ-GFIKVD--DI--LKNNLFK------------NTNFKEIQEVVDTND-KKRYHMELNds------------------------------------------------------------------------------------------------------------------------------------------------------------dgCYYIRANQGHT--LE--------NVDNVEM---TKIT-----------------------SADQVG----TVFHGTYRKHL-QSILNEG--LKKMDRNHIHCVNKIm-----------------------GQEITSGMRGS-CNMIVYIDVPLLLQ-D------------GIDLYLSQNNVALTDGLQNNVALTDGLNNTGILPPKYFIKI  190   Dictyostelium discoideum AX4                             eukaryota>amoebozoa>mycetozoa>dictyosteliida
50547707   131  15    SRKLSYILRHG--ATK-EKLP--IRED-GYLSVG--VL--LNRAGIK-----------GKWNLEDTKRVVRDND-KQRYKLIFEptd------------------------------------p--------------------------------------------------------------------------------------------------------------------ndctGYWIRANQGHT--IN----------TKVEM---KALK-----------------------TPEDFPT--LEIFHATSKQVL-PIVLKEG--LSKMKRQHIHLATDLvt----------------------EGGSVAGKRLN-REVFIYINVPKALE-A------------GIEFFLSENGVVLTELSENGVVLTEGKDGKISREFFSKILD  198   Yarrowia lipolytica CLIB122                              eukaryota>fungi>ascomycota                  
170105752  133  5     SKTLSYLLRHG--AQG-EGLP--MRKD-GYVKVA--DL--LQNPKLK----------TQGLDLDKIRDIVGKDS-KQRYDLISDst-----------------------------------------------------------------------------------------------------------------------------------------------------------dpnVWWIRARQGHS--LK---------TVELDL---KPIL-----------------------SATDIST--GVAVHGTTLAAW-ESISKQG--LSKMKRNHIHLAQGLpg----------------------HNGVISGMRSS-SQIFIYINIQAALS-S------------GIQFFFSDNGVVLTFFSDNGVVLTAGDDKGFLKPEFFLRVE  178   Laccaria bicolor S238N-H82                               eukaryota>fungi>basidiomycota               
336366767  134  31    SKSLSWLLRHG--AQS-DGLV--LRSD-GYARVA--DV--LANPRFR------------GVTYPMLEDIVRQDR-KQRYNLLCEags----------------------------------leas-------------------------------------------------------------------------------------------------------------------sgsdVWWIRANQGHS--IK---------TIEIEL---NPIA-----------------------SATDIP----MAVHGTNRKAW-ELISTQG--LSKMKRNHIHLAQGIa-----------------------GDSVVSGMRKS-SQILIYIDVQKAID-A------------GIKFSLSSNGVVLTELSSNGVVLTEGDETGFLAPRFFQRVE  206   Serpula lacrymans var. lacrymans S7.3                    eukaryota>fungi>basidiomycota               
242218580  135  2     SKTLSWVLRHG--ARS-EGLE--MRPD-GYVRVD--DLVSLKIPKMR------------EMNFDMLEQIVKADN-KSRYNLIHEpdk----------------------------------avg--------------------------------------------------------------------------------------------------------------------spsqIWWIRANQGHS--MK---------TVVLDL---QPIQ-----------------------SPADIPT--GLAVHGTSRKAW-DIICEQG--LSKMSRNHIHLAQGVp-----------------------GSGVIS-MRSS-SSILIFVDIQKALA-A------------GIRFYLSDNGVVLTDLSDNGVVLTDGDEKGFLSPQFFARVE  179   Postia placenta Mad-698-R                                eukaryota>fungi>basidiomycota               
302686072  139  4     SKTLSYILRHG--AQK-EGIP--IRPD-GYVKVD--DL--LANNRLK----------SQAVTLEMIQQIVKDDV-KQRYDLVLEqp-------------------------------------------------------------------------------------------------------------------------------------------------------------sTWLIKANQGHS--LQ---------TVKLEL---KPIL-----------------------SRADIPT--GVTVHGTMNHAW-QSISKQG--LSKMKRNHIHLAQGKg-----------------------GKDVISGMRRS-SEVFIFVDVDRAIA-A------------GIKFELSDNGVVLTELSDNGVVLTEGDERGFLPVRFFQKVE  175   Schizophyllum commune H4-8                               eukaryota>fungi>basidiomycota               
296416279  156  69    SKALSYTLRHG--AVK-EGLA--LQDD-GYANVG--EL--LQLPKFR----------KMSLTFEKLRQVVSEND-KQRFSLTPTaa------------------------------------------------------------------------tatatepaataed-----------------------------------------------------------------------phTYLIRATQGHS--LP---------LTNTSTLLTPL--------------------------PPNI----TCAVHGTFYPAY-EAILACG-YLSRMGRTHIHLATG-------------------------EIGVKSGMRAD-AQVLFYVDVGRARR-Eg-----------GVEFWISENGVVLTWISENGVVLTAGDELGRLGLEFVERVV  257   Tuber melanosporum Mel28                                 eukaryota>fungi>ascomycota                  
154295249  158  4     SKALSKLLRHA--AES-EGVE--LDGE-GFARLD--LV--MQWPRLK----------SLKPTFADIRTAVTDNA-KQRFSMKPNps----------------------------------------------------------------------------lpeapspss---------------------------------------------------------------------enpaDWMIRANQGHS--IV----------IDSAALLIPITL-----------------------EAENVP---ETCAHGTYFAFY-EEILRSG-GLKKMGRTHVHFVTGIpe----------------------DGGLVSGMRGD-AELLIFVDVKRCLE-Eqp----------EMKWWISENRVVLTEGSENRVVLTEGDGEGVVGTRFWKRVE  193   Botryotinia fuckeliana B05.10                            eukaryota>fungi>ascomycota                  
302916847  159  52    SKALSKLLRHQ--AGN-AGIQ--LDDE-GFAPLS--SV--LAWGPLR----------SLKVTLDDVQSIVTSND-KQRFTLKPNps----------------------------------------------------------------------------tnpslstts---------------------------------------------------------------------tspeDYLIRANQGHS--IK----------LESAALLAPITI-----------------------EAGNVP---DRVLHGTFFYFW-PKIVETG-GLKPMNRNHVHCSTGTp-----------------------EEGVVSGMRKD-AELVIEIDIEASLK-E------------GVKWWMSDNGVLLTEMSDNGVLLTEGDEQGILSSKFFKLAT  237   Nectria haematococca mpVI 77-13-4                        eukaryota>fungi>ascomycota                  
322707126  160  40    SKALSRLLRHQ--AEN-AGIK--LDEE-GFAPLD--R---LSWGPIK----------SLSPSLQEVKDVVETNA-KKRFTLRPAdp--------------------------------------------------------------------------------lapep---------------------------------------------------------------------psaaGYLIRANQGHS--LK----------VDEAALFEPILL-----------------------GAADLP---GKVVHGTYFAFW-KAILESG-GLKPMSRGHIHCSDRTp-----------------------EEGAVSGMRRD-AELLVEIDIEASLK-D------------GVTWWRSDNGVILTDRSDNGVILTDGGEGGVLETKYFKMVT  220   Metarhizium anisopliae ARSEF 23                          eukaryota>fungi>ascomycota                  
213408531  178  9     SRALSKVLRHT--ARS-CGLK--LTEE-GYARVD--DL--LKLPQFK------------GLTVDVLQQIVADND-KQRFALSTIn--------------------------------------------------------------------------------------------------------------------------------------------------------------dELHIRANQGHS--LT----------TVHVDMP-RIT------------------------DPAEIP----RVVHGTFAKFW-PAIYANG--LSRMKRQHIHCAKGLfg----------------------EPGVVSGIRKS-CDVFIFIDAARAMA-D------------GVVFYRSENGVILTEGIENGVILTEGIDGVLPRKFFLRVEN  180   Schizosaccharomyces japonicus yFS275                     eukaryota>fungi>ascomycota                  
310792989  170  37    SKALSKLLRHQ--AEN-AGLK--LDEG-GYAPLD--KV--LAYGPIR----------SLQVSFADIQAAVTTSD-KQRFALKPNav----------------------------------------------------------------------------tnpsldeks---------------------------------------------------------------------tepsHWLIRANQGHS--IK----------VDSAGLLTPITL-----------------------DAGNVP---EVVVHGTYFAFW-RAIEESG-GLARMGRNHVHFATGLpgd---------------------EQGVVSGMRRD-AEVLVYVDVERALR-Eee----------GMRWWVSENGVVLTEGSENGVVLTEGDEEGRVPTRLFREVR  227   Glomerella graminicola M1.001                            eukaryota>fungi>ascomycota                  
19115427   179  38    SKALSKVLRHT--AKA-NGLQ--IRED-GYIEVD--SI--LKLPQFR------------GMGMELLLSIVKGND-KKRFTMEEVe--------------------------------------------------------------------------------------------------------------------------------------------------------------gVLYIRANQGHS--IK----------AVQVPMA-RI------------------------dNASSIP----KVVHGTKKELW-PVISKQG--LSRMKRNHIHCATGLyg----------------------DPGVISGIRKS-CTLYIYIDSAKAMQ-D------------GVEFYRSENGVILTEGVENGVILTEGVNGLLSSKYFSRVET  207   Schizosaccharomyces pombe 972h-                          eukaryota>fungi>ascomycota                  
326431934  185  660   SKYLSYVLRHG--AQK-EGVS--MAPD-GSVALE--DL--LRRPQLK------------GLSSKEIKHIVETCP-KQRFVLLPGt------------------------------------------------------------------------------------------------------------------------------------------------------------gptGLRIRAAQGHT--IK---------VADESQLLTAIT------------------------DASKFP----VVVHGTYAKLV-PVIKREG--LSRMRRRHIHFATGLpg----------------------DQEVKSGMRKS-CTAFVYIDLAKCLR-D------------GIPFFVSSNNVVLSFVSSNNVVLSPGLGSTGILPPQYFTNV  832   Salpingoeca sp. ATCC 50818                               eukaryota>choanoflagellida                  
303284891  186  69    ---LSQLLRHG--ALD-AGLGDVLTPA-GGVPLD--RV--LALPRFK------------GVTAEAIETLVANCP-KRRFELFLAek------------------ggggd------------------------------------------------------------------------------------------------------------------------------------dvtTKMIRATQGHS--IRg-------GALDDDAMLARVSV---------------------erARAELR----YAVHGTSLRAW-ETIKTEG--LLRMRRRHVHLAAALpgs---------------------ADEVTSGMRSD-AQVAVWVDVAAAVA-D------------GVAFFVAANGAVLTPGVANGAVLTPGVGRDGVLHPRYFHRA  253   Micromonas pusilla CCMP1545                              eukaryota>viridiplantae>chlorophyta         
255086119  187  3     SKNLSQILRHG--VVD-EGLADCLDAE-GFVPLA--RV--LALPRFR------------GVGADEIRALVAADR-KGRFELRDRt-------------------------------------------------------------------------------------------------------------------------------------------------------------dgIVHVRATQGHT--LRg-------DVLDDDAMATRLT------------------------RTSGIR----EAVHGTSMRAW-KRIRTHG--LSRMRRRHVHMATGLpg----------------------DGEVKSGVRND-CEVAVWVDVERGVA-E------------GVPFFVSANGVVLSFVSANGVVLSPG---------------  176   Micromonas sp. RCC299                                    eukaryota>viridiplantae>chlorophyta         
167518371  190  1     ---MTYLLRHG--AEK-EGVP--MSKD-GFVHTA--DL--RRHDKLR------------HLDDDTVREIVATDA-KGRFELRE----------------------------------------------------------------------------------------------------------------------------------------------------------------gPLRVRATQGHS--LN---------VQEDSLL-DPVL------------------------SAADWP----VVVHGTYHAAW-AQIQREG--LRTMGRQHIHFSTAEpg----------------------SREVISGMRTT-CNVWIYLDLDQVLR-D------------GIPVFISRNRVLLTFISRNRVLLTAGQDGVLHPRYFKRVVR  163   Monosiga brevicollis MX1                                 eukaryota>choanoflagellida                  
145493555  191  14    SKAMSYLLRHG--AQK-EGIP--IRQD-GFVLVQ--DL--LNWKSMA----------NLKANVQSIRNVVDNND-KKRFELKEId--------------------------------------------------------------------------------------------------------------------------------------------------------------gQLYIRCVQGHT--IE---------INEEELL----------------------------gENTQFP----VIVHGTYFQAW-ELIKNTG--LNRMARQHIHFAVGLpg----------------------NDAVISGMRNT-CEVIIEVDMERAMK-A------------GIEFYVSKNGVVLSSGIKNGVVLSSGIDGVIAPQFFKRVTT  187   Paramecium tetraurelia strain d4-2                       eukaryota>alveolata>ciliophora              
118362535  192  19    SKKLAWLLRHG--AEK-EGLN--MGSD-GYVLLQ--EI--MSRNDFS------------TITFDKVKSVVDNND-KKRFEMIQKeh----------------------------------------------------------------------------------------------------------------------------------------------------------ngkiEWFIRASQGHT--IS--------SINDEELL-DKISL----------------------dVASSLG----IVVHGTYKQFW-EPISKEG--LKTMQRNHIHFAIGYpg----------------------DKEVISGMRKT-CDVYIEIDLVKAIN-D------------GIDFFMSKNNVVLTSGIKNNVVLTSGINKVLPPKYFKVVKD  196   Tetrahymena thermophila                                  eukaryota>alveolata>ciliophora              
322802863  196  9     SKRLSYLLRHG--AVK-EGLN--IKPN-GFITVE--DL--LNK-SLL------------QYTIDDIKRVVKTNN-KQRFTLATId--------------------------------------------------------------------------------------------------------------------------------------------------------------gILKIKANQGHS--IP--------TINQLSL---RIL------------------------EFIDF-----DIIHGTYLKYW-PKIKTEG--LSRMKRNHIHFAKGL--------------------------NFINGLRQS-ADLFIYVNFDKAKE-D------------GLIFLESENGIVLCAGNENGIVLCAGNSKGFIETRYFLKVI  178   Solenopsis invicta                                       eukaryota>metazoa>hexapoda                  
156543836  197  47    SKKLSYLLRHA--AVK-KGFN--IRPD-GFIPVQ--EI--LKETP--------------GCTVKDIERVVANND-KQRFTLSSFd--------------------------------------------------------------------------------------------------------------------------------------------------------------nVLMIKANQGHT--IS--------QVDSLNL---KLL------------------------DSVDF-----DIVHGTYHSCY-EKIRHQG--LSRMKRNHIHFAKGL--------------------------NFINGLRRN-AELFIFINYPKAKG-D------------GLKFYKSENNVILCYKSENNVILCPGNSEGFVKTKYFLKSY  209   Nasonia vitripennis                                      eukaryota>metazoa>hexapoda                  
328862875  199  5     SKTLSYLLRHG--AAK-EGLK--MRSD-GFVKIN--DL--LARPKLK------------GVELGDIERIVGKDS-KQRYAMIREpp------------------pdgssss-----------------------------------------------------------------------------------------------------------------------------------edIVYIRANQGHS--IQ---------VPELDL---VPII-----------------------DPEDIP----TVVHGTYMKFW-DTILLEG--LKPMKRTHIHFASGLid----------------------QPGVISGMRAS-REIDIYLDVTKCIS-A------------GILFHRSKNGVILSQGLPNGVILSQGLPDSNSIPSTYFQKV  193   Melampsora larici-populina 98AG31                        eukaryota>fungi>basidiomycota               
331216956  200  54    SKTLSYILRHG--ALK-ERLV--IRAD-GCIRLD--DL--LKRPKLK------------NYTIDDVRRVVAENE-KQRFALVDEqa------------------adgs---------------------------------------------------------------------------------------------------------------------------------------iVNYIRANQGHS--IK--------EVDQPDL---TPLI-----------------------DPIELP----TVVHGTYSKFW-DSIAQDG--LKPMSRTHIHFAKGLlg----------------------EEGVISGMRAS-CDTFIYLDVEKCLQ-A------------QIEFFLSSNGVILSEGLPAGVILSEGLPASKSIPAQYFKKV  231   Puccinia graminis f. sp. tritici CRL 75-36-700-3         eukaryota>fungi>basidiomycota               
260781042  203  22    SKSLSYLLRHG--AAK-MGFQ--LDPG-GFLYVD--EV--LKHPQFK------------RYTADDVRQVVADND-KKRFALQEEeg------------------------------------------------------------------------------------------------------------------------------------------------------------tgRLQIRANQGHT--LE---------VEELDL---TPIT-----------------------DPAEAP----TVVHGTFLSCW-DKIRTQG--LSRMRRNHIHFAPGEpg----------------------EDGVISGMRRT-CQVLVFIDMEAAMR-D------------GLQFFRSANNVILSFRSANNVILSPGNEEGLIPPKYFQQVL  192   Branchiostoma floridae                                   eukaryota>metazoa                           
72010085   204  6     SKLLSLVLRHR--AQQ-LGFN--IYPG-GYVLVK--DL--LAHKMFK------------RFTEADIRRVVASND-KQRFSFKTNee------------------------------------------------------------------------------------------------------------------------------------------------------------tgELMICANQGHS--FD---------VPEPEL---EPIT-----------------------DASRFR----TVVHGTYFRHW-DQIRRQG--LKRMNRTHIHFAQGVpg----------------------ADGVISGMRRS-CQVMIFIDLPAALR-G------------GVKFFLSKNGVVLSFLSKNGVVLSPGDKDGILRTRYFSSVM  174   Strongylocentrotus purpuratus                            eukaryota>metazoa>echinodermata             
221487185  210  907   IKKLNFILRHGAPLFK---LP--MRED-GYVRIR--EL--LELDCMR------------SVSWEEIYLVVASNF-KRRYEICYDptepehvgetgdlcvldelrnpvsqetmppavpptddasdlsfsptshhdadrkaarreeatkntnitssrtedrlhspasssasfsssadsskaryesaafpedaslgekslfsslrgrqaregdasggsggsgfcdvpafpssaapelandrwllratQGHLRATQGHT--IR---------QVASDLLL-RSIC-----------------------DPGELP----VCVHGTFLKNW-MAIRSAG--LSRMHRNHIHFAPGLps----------------------ECGVVSGMRRS-SDVAIYVNVHLAMK-E------------GVRFYVSNNNVILTEGLNNNVILTEGLRGKLVPSSSKSTGM  1229  Toxoplasma gondii GT1                                    eukaryota>alveolata>apicomplexa             
198415504  211  420   SKELVRIVRHG--KYN-QQIQ--MDAE-GYVFVN--DI--LTCKRFY--------dqFPGVNELYIEKIVESND-KKRFELKFEe-------------------------------------------------------------------------------------------------------------------------------------------------------------gvGWKIKAAQGHT--VK---------IENRSL---RPIT-----------------------NPAEFP----VVIHGTYWENW-EFIKVNG--LNRMGRNHIHFAPGLpn------------------------EVVSGMRKS-CEVAIYINMTQALK-D------------GFKFFQSSNQVILTEQSSNQVILTEGDEKGRIHPKYFLKVV  590   Ciona intestinalis                                       eukaryota>metazoa                           
157042782  216  26    SKSLSYVLRHG--ASK-MGLQ--MNSD-GFVFVE--EL--LAHQQFR------------SFSVDDVERVVASND-KQRFKLCKHp------------------------------------------------------------------------------------------------------------------------------------------------------------eddRLQIRANQGHS--VQ---------VTDLEL---REISq----------------------DDQDYP---REAVHGSYMKHW-PSIRSQG--LSRMNRTHIHLAPGLpg----------------------EGRVISGMRQS-CDLAVYIDVTKAMS-D------------GIKFFWSENGVLLTFWSENGVLLTPGDAAGILAPCYFSRAQ  196   Danio rerio                                              eukaryota>metazoa>vertebrata>actinopterygii 
197246418  219  24    SKCLSYALRHG--AVN-LGLP--MGTD-GFVPVS--SL--LLLPQFR------------TFSQVDIERVVSCND-KQRFTLRYSy------------------------------------------------------------------------------------------------------------------------------------------------------------adgALEIRANQGHS--LQ---------V-EVELTPL----------------------------GEELP---NQAIHGTYFRHW-PSIQQRG--LSRMNRTHIHLCTELpge---------------------GQECISGMRRD-CEVAIFIDLPKAVA-D------------GLLFFWSSNRVLLTFWSSNRVLLTPGNADGLLLPKYFLRAL  191   Xenopus (Silurana) tropicalis                            eukaryota>metazoa>vertebrata                
297267544  220  32    SKALSYALRHG--ALK-LGLP--MGAD-GFVPLG--AL--LQLPQFH------------GFSAEDVRRVVDTNR-KQRFALQHGd------------------------------------------------------------------------------------------------------------------------------------------------------------pstGLLIRANQGHS--LQgshcclfNQVPELELMPLE--------------------------TPQALP---PMLVHGTFWKHW-PSILLKG--LSCGGRTHIHLAPGLpg----------------------DPSVISGMRPH-CEIAVFIDGPLALAAD------------GISFFRSANGVILTFRSANGVILTPGNTDGFLLPKYFKEAL  211   Macaca mulatta                                           eukaryota>metazoa>vertebrata                
238550149  220  32    SKALSYALRHG--ALK-LGLP--MGAD-GFVPLG--TL--LQLPQFR------------GFSAEDVQRVVDTNR-KQRFALQLGd------------------------------------------------------------------------------------------------------------------------------------------------------------pstGLLIRANQGHS--LQv-------gVPKLELMPLE--------------------------TPQALP---PMLVHGTFWKHW-PSILLKG--LSCQGRTHIHLAPGLpg----------------------DPGIISGMRSH-CEIAVFIDGPLALA-D------------GIPFFRSANGVILTPGNTDGFLLPKYFKEALQLRPTRKPLS  230   Homo sapiens                                             eukaryota>metazoa>vertebrata                
327286590  221  99    SKALSYTLRHG--ADK-LGLA--MGAD-GFVDVA--EI--LRLPQFK------------AWSLEDVQRVVETNE-KQRFALRPHp------------------------------------------------------------------------------------------------------------------------------------------------------------sdaHLQIRANQGHS--LQ---------VSELELVPLL--------------------------NPSDFP---EIVAHGTYLHHW-PAIRKDG--LSRMGRSHIHLAPGLpg----------------------DAAVLSGMRNN-CEVAIVIDIAKALAAD------------GIPFFRSANGVILTFRSANGVILTPGDAQGLLLPCYFREAL  269   Anolis carolinensis                                      eukaryota>metazoa>vertebrata                
195016166  226  11    SKQLSWLLRHG--AQK-EGLT--IQPD-GFVSIN--EI--LKHSRFG-----------SQYTREKLRQIVSTDA-KQRYTLRSNp------------------------------------------------------------------------------------------------------------------------------------------------------------ltgAEEIRANQGHS--LK---------AVQSEVC-MERIG-----------------------SISELP---SAVVHGTYYSNW-ERIKIEG--LKRMQRNHVHFALFNgdgd--------------------NRAVLSGFRSD-CQVLIYLNVAKVLG-D------------QLPMFRSSNNVILCAGISNNVILCAGIDGCIDKRYFERAIE  188   Drosophila grimshawi                                     eukaryota>metazoa>hexapoda                  
28575019   227  4     SKKLSWLLRHG--AKT-EGIT--IRAD-GFVSVP--DL--QKHPRYL------------CFTLEKLKEIAAADA-KQRYTLRWNp------------------------------------------------------------------------------------------------------------------------------------------------------------elgVHEIRANQGHS--LA---------VLEGEAGGLENIT-----------------------HVSQVP----LAVHGTYYRHW-GAIRSQG--LSRMNRNHVHFACSDe-----------------------TNSTLSGFRSD-CQILIYLNVEKVLA-D------------GIPIYRSSNNVLLCPGISNNVLLCPGIEGFIHSSYFQRVVD  185   Drosophila melanogaster                                  eukaryota>metazoa>hexapoda                  
198471764  228  13    -KKLTWLLRHG--AVK-EGIA--IQPD-GFVNIS--DI--QSHPRYA------------VFSLPKLQEIVADDA-KQRYILRWNe------------------------------------------------------------------------------------------------------------------------------------------------------------dakFHEIRANQGHS--LA---------AVQGEAC-LERIS-----------------------NAKQVP----LAVHGTYYRCW-EAIKAQG--LGRMRRNYVHFAVSDv------------------------GETLSGFRSD-SQLLVYLDVAKVLA-D------------NLPLFRSSNNVILCAGVSNNVILCAGVDGFIDKTYFSRAVD  183   Drosophila pseudoobscura pseudoobscura                   eukaryota>metazoa>hexapoda                  
91080221   231  9     SKTLSWLLRHS--AAT-EGLS--LTPE-GFAPVS--EV--LNHRQLR-----------GKFTVEDIQRIVESNN-KQRFFLRQNg--------------------------------------------------------------------------------------------------------------------------------------------------------------aILEIRANQGHS--MQ---------VTELELAS----------------------------YLNDPN---VDVVHGTFFRNL-DAIKRIG--LSRMSRNHIHFTRDL---------------------------AL--IRKN-VQVLIYIDVAKALS-D------------GIKFYMSSNGVILSYMSSNGVILSPGNEKGILEPKYFWKIV  168   Tribolium castaneum                                      eukaryota>metazoa>hexapoda                  
298711928  238  59    SKRLTYALRHG--AEK-LGLR--LRPD-GFVSLD--EL--LSKPSFR------------GVSREQVEQVVASDE-KGRMTIATFp------------------------------------------------vsggeaagsasacadpgaatn-----------------------------------------------------------------------------------------qAVFIRANQGHS--VKg--------VIDEEKLLTRVE------------------------DAADVP----VCVHGTDRKSW-SNIREEG--LRCMNRTHIHFAAGLpg----------------------ESGVISGMRKA-CKVLIYVDVAAAMS-D------------GVAFFRSTNDGVAFFRSTNNPARTAPWSQGTSPALTALLLP  244   Ectocarpus siliculosus                                   eukaryota>stramenopiles                     
198425598  207  535   ---LSSVLRHN----K-YGFK--VDKE-GYVPVD--AI--LKHQHFK----------KLGLTREEMHRIVREND-KQRFTIQVNed-------------------------------------------------------------------------------------------------------------------------------------------------------------gMEIIKANQGHS--VE---------VSSLNL---MTIT-----------------------DACEFH----DVIHGTFWTAW-KSIRKQG--LHCRKRMHIHMTTAEpns---------------------DQQVISGMRYS-CNVFVHIDMGQAIK-D------------GIPFFLSENKVILSFLSENKVILSPGDKNGYLRPKYFRKVE  700   Ciona intestinalis                                       eukaryota>metazoa                           
291231763  206  401   SKKLSNILRHN--ANK-FGFQ--LDKG-GFLNVE--DM--LHHQHFR------------GYTIEDVKRVVTNND-KQRFALRNHpd------------------------------------------------------------------------------------------------------------------------------------------------------------snLLQIRANQGHS--VK---------VQGLEL---KRIT-----------------------DASEYP----TVIYGTYSKHL-ERIKEKG--LSRMGRNHIHFAPGMpd----------------------EVGVISGMRWD-CDVIIVLDLEKAIK-D------------GIEFMISANNVILSSGDEHGYILSSGDEHGYISV-------  577   Saccoglossus kowalevskii                                 eukaryota>metazoa>hemichordata              
145602059  162  26    SRALSRLLRHQ--AAN-AGIQ--LDGE-GYAPLD--KV--LAWGPIK----------SLKATLPEIREAVSSSD-KQRFSMKPLs-------------------------------------------------------------------------------astspds---------------------------------------------------------------------tdpaDFLIRANQGHS--IK----------LESAEHLTAVTV-----------------------EAGNVP---EVVVHGTYYAFW-PAIVASG-GLRPMGRNHVHCSTGLpss---------------------EAQVVSGMRRD-AELLVYLDVERALR-Dg-----------EMKWWLSDNGVVLTEGGQG------GLVPVKYFQGGLVPVK  223   Magnaporthe oryzae 70-15                                 eukaryota>fungi>ascomycota                  
85109317   164  52    SRALSRLLRHQ--AAS-AGIT--LDAE-GYAPLD--KV--LAWGPIR----------SLKPTFPEILKAVKESD-KQRFAIKLApg----------------------------------------------------------------------------kekedgeks---------------------------------------------------------------------eepgDWLIRANQGHS--IK----------LESEGLLRRLVLgrgggggqqqqqqqgqetegedgGTIPIP---ETVVHGTYFAFW-DKIIQSG-GLKPMGRNHVHFSTGLpedt--------------------ERGVISGMRSD-AEVLVFVDVERSIR-DaeeaekedkegkGIKWWMSDNGVVLTEGDKD------GLVPLKYFKDGLVPLK  287   Neurospora crassa OR74A                                  eukaryota>fungi>ascomycota                  
116192183  166  62    SRALSRLLRHR--AGD-AGVE--LDRE-GFADLG--RV--IQWGPIR----------ALAPTFSEILNAVHNND-KKRFTIKPNpa----------------------------------------------------------------------------tnpdldess---------------------------------------------------------------------tnpsEWLIRANQGHS--IK----------LDSEHLLKALALpadd----------kdgtaalpeGAVAIP---PAVIHGTYFAFW-PSIVASG-GLKPMGRNHVHFSTGLpeds--------------------EAGVVSGMRRD-AEVLIYVDVAASLK-Dg-----------GIKWWISENGVVLTEGDVN------GLVPLKYFVNGLVPLK  276   Chaetomium globosum CBS 148.51                           eukaryota>fungi>ascomycota                  
312220715  174  15    SKKVSWLLRHG--AAS-EGLK--LGKG-GYVNVQ--DA--LNTKTLK----------SLSVTFPELREVVANND-KQRYSMILAs---------------------------------------------------------------------aldgtdtaqppqenpes---------------------------------------------------------------------dkpsDYLIRANQGHS--IK----------VDTDGLLTPITQ-----------------------EAGNIP---ETVIHGTDEPAW-NLILKSG-GLRRMGRNHIHFASGLpagfkplapstdsaedhke-----SAPVISGMRKN-SSILIYIDIEAALA-A------------GIKFFVSENGVILSEGNEQ------GLLPYEFFEQGLLPYE  245   Leptosphaeria maculans                                   eukaryota>fungi>ascomycota                  
224002288  181  59    SKSLSWVLRHS--APS-LGLR--PSPD-GYFSVE--DM--LSLKHPRfcnkgsshngGRKYTVDDIRRVVESSD-KQRFRLEYKd-------------------------------------------nqylakmmkhekssdrgetaatsnakestnapakldgssdnes-----------------------------------------------------------------------nlVLCIRANQGHS--FS--------KHIESDKLHTPLTK----------------------eELSDPNL---TIVHGTTRKAWEDHIRIEG--LSRMKRTHIHFATGLpts---------------------DNKPISGMRAT-SQIYIYINGEKCAK-D------------GVPFFKSDNGVILTAGVNEF-----DGLPVKYF--------  303   Thalassiosira pseudonana CCMP1335                        eukaryota>stramenopiles                     
219121541  182  5     SHRLSYVLRHG--ALD-MGLE--MTAD-GYVPVD--SL--LILQHPKfi--------GNQWTLQDIRDVVSDSD-KQRFKLREKp--------------------------------------------------------------------------------------------------------------------------------------------------------------aSDYGQATQRHT--IS---------FIKPELLLVRLSA----------------------eELRRIP----TIVHGTYSALW-PAIQISG-GLSRMKRTHIHCASGLig----------------------ENGVISGMRRG-CDVYIYINAEACAD-A------------GVVFYRSDNGVLLTAGIKI------GGLPCKY---------  199   Phaeodactylum tricornutum CCAP 1055/1                    eukaryota>stramenopiles                     
226471272  209  101   SKKLACILRHA--AEN-VGMN--YEPG-GYLYVD--KI--LQLKPFQ------------GVRVEDILRVVNSND-KKRYEVSTNpe------------------------------------------------------------------------------------------------------------------------------------------------------------ngRLKIRAFQGHS--VP---------IDGLDI---TLIE-----------------------NPENYP----NVIHGTYFRNW-ESIRKEG--LKRMRRTHIHFAPGEig----------------------ESGVISGLRSS-AEILIYIDLAKAMK-D------------GYKFYISKNNVILCEGNAD------GCLPTKYFADGCLPTK  282   Schistosoma japonicum                                    eukaryota>metazoa                           
225707394  217  31    SYSLSFTLRHG--ANK-LGLH--MNPD-GFLFVE--DL--LAHPQFR------------SYSLEDVERVVAAND-KKRFKLCRHp------------------------------------------------------------------------------------------------------------------------------------------------------------edgRLQIRANQGHS--LQ---------VPDLEL---RPVQa----------------------GSPNCP---VEAVHRSYLCHW-TSIRTQG--LSRMARTHIHLC--Lpg----------------------EEGVAGGSSDV-RDLAIYIDVPKALA-D------------GIQFFLSENGVLLTPGDTE------GKLPLKYFTEGKLPLK  212   Osmerus mordax                                           eukaryota>metazoa>vertebrata>actinopterygii 
320168635  233  31    SKLLSYILRHG--------VP--ISPE-GFVDVE--VL--LGFPDFR------------AYTVADVRRAVTSSD-KQRFALEERi---------------------------------------------------------------tddnpv-----------------------------------------------------------------------------------------aRLYIRANQGHT--IE---------VEALELSPIT--------------------------ASEDAP----IVVHGTYDAAW-DLIKSQG--LSRMKRNHIHFAVGLpg----------------------ASGVISGMRSD-VTVLIYLDVARALA-D------------GIPFFRSSNNVILSPGLEN------GSIPAKYLENGSIPAK  210   Capsaspora owczarzaki ATCC 30864                         eukaryota                                   
66358336   243  10    SKKLTWLLRHGD-PAK-TGLN--MRND-GYVEVN--EI--LKQT---------------CISLEKLHYIVENDP-KGRFRIIDEn--------------------------------------------------------------------------------------------------------------------------------------------------------------gKNLIRANQGHS--LS---------FIEDEKLLARFEI--------------------dnnSEFIQR----IIIHGTYLDKW-KNIKING--LSRMSRSHIHFVSATnf----------------------KLESIKQGSKI-SEDMCIDQIVREMC-Ny-----------KCTAGIRPNYKCTAGIRPNC-----EVLVFIDVVNCVTNSA  176   Cryptosporidium parvum Iowa II                           eukaryota>alveolata>apicomplexa             
310831101  247  1     SKKLSYYLRHN------LDIFN-YSKD-GYVKIS--EL--REKNIIK-----------KNTTIDAIDKIVKNDS-KNRYDLKFEi-----------------------------------------------------------------nngy-----------------------------------------------------------------------------------------kEYYIRANQGHS--SG---------NLDYSLILEE--------------------------IKEPIP----NIFHGTFIKKI-DSIKNTC--LNKMTRHFIHFAAD-------------------------DIIHNHLKRSI-SQVKVYVDMKKAMD-D------------EIKFYYAKNKVILSNGKNND-----GIIPAKYNNDGIIPAK  184   Cafeteria roenbergensis virus BV-PW1                     dsdna viruses, no rna stage                 
110645302  248  14    SRSMCYLLRHD------RNFI--TSSD-GFVSID--TL--AKKL---------------NISNQQITEIAHRDS-KNRYEINN------------------------------------------------------------------------------------------------------------------------------------------------------------------DMIRAVQGHS--NR---------HVDFKMDKV---------------------------AINYKG----IAVHGTFKKHL-NSIISHG--LKRMSRNHIHLATS----------------------------KNNARKN--ANVFIYINIRHCLK-D------------GMIFYFSSNGYILTMGFD-------GTIPSKYIVKYEFASK  174   Neodiprion abietis NPV                                   dsdna viruses, no rna stage                 
302851356  255  501   SKEMSRLLRHKP-PPG------AMDAA-GWVSLP--VL--LRHMR-------------NHPSEEQVRRIVETCD-KKRFVIDDSv--------------------------------------------------------------------------------------------------------------------------------------------------------------nPPRIRAAQGHS--VE---------LTEAVLEPV--------------------------vDPSKVP----IAVHVTSVSSW-EAIRTSGQ-LMRMNRTHIHFATE---------------------------PHHMRKNKW-AEIYLRLDLAAALE-Q------------GRQFFLSSNGVLLCE----------GPVPVSLVEEGPVPVS  678   Volvox carteri f. nagariensis                            eukaryota>viridiplantae>chlorophyta         
307104106  256  1     -----------------------MDAS-GFVPLP--VL--LQELR-------------SPGATEAVVRHVVASDLKGRYELDESs--------------------------------------------------------------------------------------------------------------------------------------------------------------vPPRIRAVQGHS--VH---------LAAPQLAPV--------------------------gSADEVP----LALHITSLEGW-KAIQDSGE-LRRMSRTHVHFGTE---------------------------PGHLRRNSW-ATVLLRLDLRQAMQ-D------------GHAFFLAANGVLLCE----------GPLPARYLEEGPLPAR  155   Chlorella variabilis                                     eukaryota>viridiplantae>chlorophyta         
157126123  259  57    ---FSWLLRH---SAA-VAEH--MDPD-AFVEFE---V--LQQI--------------SGASKDRMLELIAQDQ-KGRYEIRG------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVRAVNGHS--VH---------FCDNYEVL----------------------------SGERRP---EFLYHATNDKAL-PLIMAGA--LKRMGRHYIHMYDGPpq------------------------KTSVRYR------ILRIRPL-----P------------GHTLYRTKNGYILCR----------EDIPAEFIEREDIPAE  210   Aedes aegypti                                            eukaryota>metazoa>hexapoda                  
262195534  260  6     SRRISSLLRHR--AGD-AGLS--MDAA-GWVEID--AL--LAHL---------------GESRELLDAVVQTNN-KARFEVAG------------------------------------------------------------------------------------------------------------------------------------------------------------------TRIRASQGHS--LEnmpv-----TRDALEAS----------------------------WSRFDGE--DSLWHGTQPEVV-ESIARDG--LLHGARSHVHLAESR--------------------------DSSVGKRSN-VGVLLEISPSELRA-A------------GWELFKSPNGVILCR-----------HVPPECILCRHVPPE  176   Haliangium ochraceum DSM 14365                           bacteria>proteobacteria>deltaproteobacteria 
284033571  261  2     SKRLSWLLRHG--AGE-QGLA--MTAD-GWASIE--DV--CVLT---------------DISRPALDRAVERND-KNRLEVDG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRIRACQGHS--LAgmpv-----TREALENS----------------------------WRRVHPA--DLLWHGTTRAAV-EAIRREG--LKPGRRTHVHLAPSR--------------------------DSHVGKRFA-AAVLLAVDPVDL------------------VVFEAPNGVLLTR-----------QVPPDAILTRQVPPD  170   Kribbella flavida DSM 17836                              bacteria>actinobacteria                     
162450235  262  1     SKKLSWLLRHA--APS-QGVA--MDDA-GWVAVD--DV--LKAL---------------RISRPVLDEVVEKNT-KNRLEIRG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRMRASQGHS--RDgmpv-----TLAGLEAS----------------------------WEEVHDD--ASIWHGTSVDAV-RGIARDG--IRPAARTHVHCTDAL--------------------------GSAVGKRAK-VDVMLEISPARLRA-R------------GVRVFRSQNGVILVR-----------EVPVQCLLVREVPVQ  177   Sorangium cellulosum 'So ce 56'                          bacteria>proteobacteria>deltaproteobacteria 
20094870   313  39    SKLLSGILRHF--PEE-VKVK--LDDE-GFTDCDVHEL--AERIKKYw----knreyYRWLTGEHIIAVVETCP-KGRFEIDEH-----------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHSRRLS----------VRPTL------------------------------PEAENV---KELYHGTARENL-ESILQHG--IKPMGRRAVHLTDDE------------------------REALITALRHTRNPVILVVDAERLRR-H------------GLVPRKAGKNVYVVEG----------TVPPDCITRVIRNPR  218   Methanopyrus kandleri AV19                               archaea>euryarchaeota                       
118430933  314  40    SKTLAGILRHH--PGR-YGVR--LTRE-GWARVS--EV--VEGLRKA---------gWSWVEEWHIVGVALHDP-KGRYELRN------------------------------------------------------------------------------------------------------------------------------------------------------------------GEIRARYGHS--IP----------VNVEP------------------------------LPGEPP---PILYHGTTEEAL-PLIMERG--IMRGRRLKVHLTSSL------------------------EDAVSTGRRHGNLVAVLLVDVECLRR-R------------GLKVERMSKTVYTVD-----------WVPPECIAEVRRESL  208   Aeropyrum pernix K1                                      archaea>crenarchaeota                       
119871538  315  35    SKLLSLALRHS--PHV-LGIT--LDVE-GWADIN--AV--VEGLRRA----------GLPASPQVLKAVAQLDD-KGRFEIRD------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVRARYGHT--IK----------VQIRY------------------------------EVDLDT---RLLYHGTALYVL-PSILSQG--ILPMRRLYVHLAVDV------------------------ETACLNARRRQ-NPAVVEVDADCVRK-S------------GNPIYKATEKIRLTP-----------YVPPTCVKKWAICPT  199   Pyrobaculum islandicum DSM 4184                          archaea>crenarchaeota                       
18314222   316  35    SKLLSLALRHS--PSV-LGLS--LDKG-GWADVK--TA--LEGLRKA----------GIRADYEALYAVVALDE-KGRFELKD------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRARYGHT--ID----------VEVEY------------------------------EADSES---KVLYHGTSRHLL-PSIMAQG--LLPMRRRYVHLSPDF------------------------ATACQNARRRP-LPVVIEIDAECLRA-R------------GYVVYAASGKVRLAK-----------HVPPECLKKVVDCPT  203   Pyrobaculum aerophilum str. IM2                          archaea>crenarchaeota                       
145591275  317  38    SKTLSLALRHS--PAV-LGLV--LDSR-GWGEVE--AV--LRGLDRA----------GLKISREALEAVVALDD-KGRFEMSN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRARYGHS--ID----------VEVEY------------------------------EVDEDS---ASLYHGTSKDNL-PFIMAVG--ILPMKRKFVHLATDV------------------------DTACLNAARRP-SPIVIEVDAECLRR-S------------GVVIYIGSRKIRLAK-----------YVPQSCIKRVFQCLS  204   Pyrobaculum arsenaticum DSM 13514                        archaea>crenarchaeota                       
126460155  320  34    SKLLSLALRHS--PSA-LGMS--LDEG-GWAPLD--AV--VAGLKKL----------GLPASAEAVEAVAQLDK-KGRFELSN------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHS--VS----------VKVDY------------------------------EVDTET---RRLYHGTTRRSL-EGIMKMG--ILPMNRLYVHLAVDF------------------------YTACETAARRQ-DPVVLEVDADCARA-A------------G-PIYKASPAIRLSK-----------YIPPTCITGVYPCEK  197   Pyrobaculum calidifontis JCM 11548                       archaea>crenarchaeota                       
305663054  322  43    SKLMSFLLRHD--PES-IGLK--MDSS-GWVYID--DL--VDGIRNRw----rnshlYRWVEKEHVIAIAMLDP-KGRFEICG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRIRARYGHSKNLD----------IEIDY------------------------------PRDIET---KILYHGTAREFI-DRISIEG--LKPMNRHYVHLTIDM------------------------VDACIVGERHSGNPVVLKIDADCVRS-H------------GIDIYIASKSIRLAK-----------HVPRKCILAKHVPRK  218   Ignisphaera aggregans DSM 17230                          archaea>crenarchaeota                       
307595891  323  37    SHLMTYLLRHD--PSA-VNLS--MDSE-GWVSID--EL--VHALRDKw-----dpkaYSWLTKEHIMAVASLDP-KGRFEIRD------------------------------------------------------------------------------------------------------------------------------------------------------------------GMIRARYGHNKSLD----------VNIRY------------------------------EVDSEV---RTLYHGTTKRAL-VRIMREG--IKPMNRKYVHLVLDP------------------------RDAYEVALRHGNDVVILKINVDCLRR-N------------DQQILIATDRIRLTD-----------YVPPQCIETDYVPPQ  212   Vulcanisaeta distributa DSM 14429                        archaea>crenarchaeota                       
126465464  326  49    --------RHY--PWE-AGLR--IDSE-GWVDID--EL--VEGIKTRw----rnneiYQWLSREHIIAVAKLDP-KGRFEIRN------------------------------------------------------------------------------------------------------------------------------------------------------------------NKIRARYGHS--IN----------VKIKY------------------------------ELEYPP---TQLYHGTSIDKL-AKIMIEG--LKPMKRQFVHLTTSL------------------------ENAVETGKRHGK-PVVLIIDTMCLKE-K------------RIPLYKATEKIYLAP-----------KIPPQCILAPKIPPQ  213   Staphylothermus marinus F1                               archaea>crenarchaeota                       
124028223  327  28    SKLMTTLLRHL--PHE-AGLR--LDPQ-GWVGID--EL--VRGIRERw----rnrhlYQWVTRDHVIAVALLDP-KGRFQLDLA----------------------------------------------------------------------------------------------------------------------------------------------------------------RGRIRAAYGHT--VR----------VELGY---------------------------rplSMDELP---DKLYHGTVAENL-ASILSEG--LKPMRRLMVHMTTDY------------------------SSAVETGRRHGPNVVVLVIDPRCLAK-H------------GIPVYRASDTIYLAP-----------SVPPNCILAPSVPPN  215   Hyperthermus butylicus DSM 5456                          archaea>crenarchaeota                       
315230724  330  35    SKLMTYILRHS--PWE-FDLN--PDDF-GFIELD--EF--IKALKSV----------YPWVKEEHVRAVAELDP-KGRFEIRE------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRARYGHS--YE----------VFLDH------------------------------EEDTES---RTLYHGTPRKNL-DSILKEG--LKPMKRRFVHLTKDK------------------------TEAYYTGLRHGKDVVILVIDAECLRR-K------------GYRIYKAGKNVRIVK-----------YVPPECIVLWEVPPE  211   Thermococcus barophilus MP                               archaea>euryarchaeota                       
156937278  331  2     SKKMTYLLRHK--E-G-F-VD--PE---GWASLD--SL--VRELRKF----------FPWVSKEHVLEVISKDD-KGRYELRG------------------------------------------------------------------------------------------------------------------------------------------------------------------DKVRARYGHT--VK----------YVRPT------------------------------LEESYE---TLLYHGTSCEAA-RAILKEG--IKPMKRNFVHLTTSL------------------------EEAIENARRKGKCIKVLIVDGECLRK-R------------GIKIYKAGKHVRVCS-----------YVPPECVVGEAVPPE  174   Ignicoccus hospitalis KIN4/I                             archaea>crenarchaeota                       
284163819  337  32    SKFVSGALRHF--PED-VGLE--LDAH-GWTDYE--AL--AGAVEAK----------YDWAEPCHVAAVIATDP-KGRFERTDA--------------------------------------------------------------------sgtddga--gn----------------------------------------------------------------------------------GLVRASYGHS--VD----------VDLGP------------------------------TDEPVP---DELYHGTAPATL-ASIREDG--LRPMSRQQVHLSGSR------------------------EAARRVGQRHANDPVVLVVDATAMLA-D------------DQRITKRGRETYTTD-----------AVAPEYIDFPAVAPE  221   Haloterrigena turkmenica DSM 5511                        archaea>euryarchaeota                       
55379941   338  30    SKFVSGALRHF--PED-AGIE--VDKA-GWTGFD--AL--RVAVERQ----------YDWADAAALAGVIATDP-KGRFERTGV---------------------------------------------------------------------gneagittag----------------------------------------------------------------------------------GRVRAAYGHS--VD----------VTLDG------------------------------TDDPVP---ATLYHGTAPRNV-DSIREAG--LKPMSRQTVHLSESA------------------------AAAREVGRRHAADPVVFVVDATAMQS-D------------DRRIVKRGTETYTTD-----------RVSPVYLTTDRVSPV  217   Haloarcula marismortui ATCC 43049                        archaea>euryarchaeota                       
11499148   341  25    SKFLSGLLRHF--GRD-FGVR--LDED-GWAELR--DV--LKILSER----------Y-GVGRKHVELIVKFDP-KGRFELKN------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRAKYGHS--VE----------VRTDW-----------------------------sEGGEIP---EKLYHATSPENL-NSILKTG--LLPMRRREVHMCSSP------------------------QEAIEVGKRHSSNPVLLEIDAKGLMQ-D------------GIEVRRKGK-VYTVD-----------FVPPKFITVDFVPPK  200   Archaeoglobus fulgidus DSM 4304                          archaea>euryarchaeota                       
327400244  342  2     SRFLSGLLRHF--PHK-FGVK--VDSE-GWASLE--DV--ERVIKER----------Y-GAGMDIIRHIVNNDP-KGRFEIKD------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHS--IA----------INTRW-----------------------------sEDGSIP---PKLYHGTRPEVV-KSIMQHG--LLPMRRLEVHLSGSV------------------------EEAIDVGRRHCPKPVVLEIDAEGMMG-E------------GIEIRKKGS-VYTAD-----------FVPPKFITADFVPPK  174   Archaeoglobus veneficus SNP6                             archaea>euryarchaeota                       
288932585  343  33    SKFLSGILRHF--PDS-FGIR--LDKN-GFADLD--EV--IRILRER----------Y-GVGKREVEAIVLFDK-KGRFEIKD------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRARYGHS--VK----------VDYRW-----------------------------sEEGKIP---EKLYHGTKPENV-KSILKLG--LLPMKRNEVHLSESI------------------------DDAIEVGKRYCKNPVVLEIDAKKMLE-D------------GFEIRKKGR-VYTTD-----------YVPSKYITTDYVPSK  199   Ferroglobus placidus DSM 10642                           archaea>euryarchaeota                       
147919656  348  40    GKIISGALRHF--PAD-LGLD--MDEH-GWVSLR--DL--TRVIERK----------YEWARSYHVDAMFKTDD-KGRYERKG------------------------------------------------------------------------------------------------------------------------------------------------------------------DKVRARYGHS--LN----------IKPDY------------------------------PEFDGD----KLYYGTSEEEA-DRILEIG--LKPVNQHFVHLSKSI------------------------EEAVKVACIRTEHPVIIEVDAKKARE-T------------GIEILDAGP-VCLTA-----------QIPAEFLQIGQIPAE  208   uncultured methanogenic archaeon RC-I                    archaea>euryarchaeota                       
20093417   349  27    GRFVSGTLRHF--PAS-AGVK--MDEY-GWVDLN--AF--CDVMKKR----------YNWMRKEYLYALVESDE-KGRYQIRG------------------------------------------------------------------------------------------------------------------------------------------------------------------FMIRARYGHS--VN----------IELDY------------------------------EESDAP----YVYYGASPEEV-DVLLENG--IFPIKQRYVHLSTSY------------------------EKAAEVALIHTESPVILQVDAFRAQE-D------------GISLKLATDYIVLAE-----------KIPPEYLYVIEEPPE  202   Methanosarcina acetivorans C2A                           archaea>euryarchaeota                       
336475983  350  27    GRFISGVLRHF--PRE-VGLK--MDDE-GWVDFE--LL--CSLLKSR----------YKWATRERLISLVESDE-KQRYEIDD------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIRARYGHS--VD----------VDLDY------------------------------PDNELP----SLYYGVSQEEV-DMLLENG--ISPIRQTYVHLSTSY------------------------GKAVEVAQIHTENPVILEIDAEKARR-D------------GMSIMDANEDIALME-----------YVPSDYVCIFDGRSD  202   Methanosalsum zhilinae DSM 4017                          archaea>euryarchaeota                       
294494713  351  27    GRFVSGVLRHF--PDD-VGLD--MDAQ-GWIELD--AF--CEAMKKR----------YKWAGKMRLVSLVESDP-KQRYEIDN------------------------------------------------------------------------------------------------------------------------------------------------------------------SFIRARYGHS--ID----------VDLDY------------------------------PLYDSD----VLYYGVSQEEV-DMLLENG--IKPYRQTYIHLSNSS------------------------QRARQAASVHTDNPVILEIDAASAAK-D------------GYEFLCANEEIVLSK-----------EILPEYIEIADDLPE  203   Methanohalophilus mahii DSM 5219                         archaea>euryarchaeota                       
288931212  354  29    GRFISGLLRHY--PDK-YRLE--MDEN-GWVDFG--KL--VRVVKRR----------FKWANQWLVKAIVYSDE-KGRYEISN------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRARYGHS--VD---------NVKLDL------------------------------PEAEEE----TLYYGTSEEEA-SRVMEVG--IKPVNRRYVHLSTTL------------------------EKGEEVARLRTDEPIVLVIDAKEAKK-D------------GIRFIKVNENIVLAE-----------EIPPKYIKDFEIPPK  208   Ferroglobus placidus DSM 10642                           archaea>euryarchaeota                       
330508961  355  26    GRLVAGGLRHF--PLD-LGLE--MDSR-GWIDLS--KL--GEVVQKR----------HRWANKEMVIALAQSDP-KQRYEISN------------------------------------------------------------------------------------------------------------------------------------------------------------------QRIRARYGHS--MD----------IELDH------------------------------PECHLP----RLYYGASEEEA-DRILEIG--LKSASQRYVHLSTTP------------------------NKAWDVAGYRTGNPKVIQVDAAPARE-A------------GVKMMTVNDDIVISE-----------MIPARFLCILASKDI  201   Methanosaeta concilii GP6                                archaea>euryarchaeota                       
116754706  356  37    GRLLAGALRHF--PDD-LGLA--MSPQ-GWVEIP--VL--VDAIRTR----------YRWANENLVMALVRSDP-KGRYEING------------------------------------------------------------------------------------------------------------------------------------------------------------------TRIRARYGHS--VG----------VDLDY------------------------------PENELP----TLYYGTAEEEA-ERLLEVG--LKSATQRYVHLSTTP------------------------DKAWEVGTFRTSNPKIIVVDAAGAQR-E------------GVRMMKVNESMVISD-----------PIPPRFLSMMPAKAQ  208   Methanosaeta thermophila PT                              archaea>euryarchaeota                       
167043400  361  28    ARRLALVLRHA--PEK-FDLE--MDIN-GWIDVK--DI--VKQFKGSne------rrYHWFRPHHIRAISETDP-KGRYEVRG------------------------------------------------------------------------------------------------------------------------------------------------------------------NVIRATYAHT--VE----------IELDL------------------------------PTDNIP---DALYYPCSPDEY-ENLIEVG--ISPSGRAHVHLSANI------------------------RSAAEAGHVHHAIPTLLEVDTARLVA-A------------GETVWHAGITVYLAE-----------FVPGKYLLAEFVPGK  208   uncultured marine microorganism HF4000_APKG1C9                                                       
10639263   362  1     SRTLAAILRHD--PER-YHIR--LDSH-GYARIA--GI--VTVLRKYk--------gMKWITFDHILSLAETDP-KGRYQVSG------------------------------------------------------------------------------------------------------------------------------------------------------------------VLIRAMYGHT--IP---------VDLSDL------------------------------PEDNIP---DVLYYQSSAAEA-PLVKEAG--IYPSDKTWVHLSGTY------------------------RRSYVSGLYHIDDPFILRIDARSMID-S------------GHDIYRSSDDIYLTR-----------EIPPEYILTREIPPE  180   Thermoplasma acidophilum                                 archaea>euryarchaeota                       
254169141  363  29    SRMLAGILRHF--PER-FGVK--LDDS-GWADIY--QI--VKGIKRRh-------prFRWLKDKHIIAIVLTDD-KGRYQLDME----------------------------------------------------------------------------------------------------------------------------------------------------------------NKRVRATYGHS--IK---------VDLSDL------------------------------PTDNIP---EKLYYPTTEEEY-EYIKEIG--LQPGDRKWVHLSKTY------------------------RDAYIAGLHRVEEPIILEIDTKKAIE-N------------GHQIYRAAKTVFIAS-----------QIPPEFINISQIPPE  213   Aciduliprofundum boonei T469                             archaea>euryarchaeota                       
29830778   369  902   SRSLSYHLRHG------RELT--QNPQ-GWVPID--SL--VRALDPK-----------LRVSADELISVARAVS-EERFEVRG------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVRARYGHS--RP----------TAIEY------------------------------EIRAPE---GRLYHCTPTTAL-HNIFERGEGLRPMTRQWVHLTTDR------------------------AAALSAGRRHGPCTLLCVPDPSAL------------------ECRHAGGATWLVA-----------QVPPSALTVVPLHRL  1051  Streptomyces avermitilis MA-4680                         bacteria>actinobacteria                     
228983067  370  4     GGFLCKILRHS--PSQ-FHVS--LDEY-GYAPID--EL--LNAISSNe-------kwVNLVTVEMILEVVKTDE-KQRYKLDST----------------------------------------------------------------------------------------------------------------------------------------------------------------GTKIKARYGHS--IA----------VKSDE-----------------------------eQNRVLP---DILYHGTGMEHL-DSIQKLG--LLPMKRVNVHLSETT------------------------FFANKSAKRNQ-FPVLLKVDTIMAKN-L------------GVTVEYAGDEVWLSS-----------PIPSDCLLSSPIPSD  185   Bacillus thuringiensis Bt407                             bacteria>firmicutes                         
251794334  371  5     SKLMTKILRHT--PEQ-FGIS--LDPEDGSCGIH--VL--LEAIQAQp--------kWAGITIEDIEQVVRNSE-KQRFAIED------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRARYGHS--HD-----------RVQY------------------------------TAGEPP---AILYHGTNRKAL-PSILGEG--LHPMNRQYVHLSEGT------------------------HFATLAGSRRG-ELVILKIDTSRAKE-A------------GVVFFFAGNEVWLAD-----------RVPADVWLADRVPAD  180   Paenibacillus sp. JDR-2                                  bacteria>firmicutes                         
310641074  372  11    SKFMSEILRHT--PEQ-FGLE--LDHE-GYCDIQ--DL--LRGIRSEd--------rWSDVSESDIKQVVSHCP-KQRYEMVN------------------------------------------------------------------------------------------------------------------------------------------------------------------GYIRANYGHS--AG-----------KLNY------------------------------EEATPP---TILYHGTNTKVI-HNLFTEG--IKPMGRKYVHLSESL------------------------EFAILAGKRRG-ELVILEVDTAKALA-N------------QVKFYKANHGVWLAD-----------LVPPQYLLADLVPPQ  178   Paenibacillus polymyxa SC2                               bacteria>firmicutes                         
334135982  373  11    SKLMSKMLRHS--PGD-FGLV--LDGE-GFCSLG--DF--LTALNRVs--------gFEDVRPEDIQRVVRECE-KQRFEIAE------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIRARYGHS--HE-----------RITY------------------------------EAAEPP---SVLYHGTNRKAV-ALIMAEG--LLPMSRQYVHLSEGL------------------------HFAALAGKRRG-ELVILEVDTALAGH-K------------GVRFYYAGNEVWLAD-----------RIPAEVWLADRIPAE  176   Paenibacillus sp. HGF7                                   bacteria>firmicutes                         
116495334  267  1     SKTLSMLLRHH--PEK-LGLV--LDQY-GRTDWK--TL--VRRFNAH---------yQMHLDRQVLQAIMAQST-KKRFALEG------------------------------------------------------------------------------------------------------------------------------------------------------------------TTIRAVYGHS--VP-----------------VMPLT-----------------------PATEPP---QWLYHGTSHQAA-TVIAKEG--LLPMNRDFVHLSEDV------------------------ATARQVGARHDTHPVIYRIAARDAAK-N------------GILFYPTSSRVWLVS-----------ELPARFLLVSELPAR  178   Lactobacillus casei ATCC 334                             bacteria>firmicutes                         
227508115  268  13    SKRLSFILRHH--PEK-IDIK--LDQY-GRTNLN--VL--IRHFNKH---------yGTPISQSIITAIIQQSD-KQRYAIEG------------------------------------------------------------------------------------------------------------------------------------------------------------------NTIRALYGHS--IP-----------------VKPLT-----------------------PPKMPP---EYLYHGTTHSAA-RLIETEG--LKKMDRDFVHLSANQ------------------------QMAIQVGRRRDPRPVVFRVAAKNAAK-N------------NVLFYPTKSGIWLVD-----------AMPAQFLEVDAMPAQ  189   Lactobacillus brevis subsp. gravesensis ATCC 27305       bacteria>firmicutes                         
338811714  270  5     SKTMSYALRHA--PWE-YELE--MDEG-GWVSII--QL--LHSLQEE--------qkWSDVKAENIYYVAKTSD-KGRFEIAD------------------------------------------------------------------------------------------------------------------------------------------------------------------SKIRALYGHS--IP-----------------LRIIK-----------------------APGEPP---QLLYHGTSRQEA-DAIMANG--LEPRGRQYVHMAVDP------------------------KMALQVGKRRDNKPVLLTIKAREARQ-D------------GVAFYKGNDLVWLAE-----------FVVAKYIDIEFVVAK  178   Acetonema longum DSM 6540                                bacteria>firmicutes                         
303240380  271  7     SKAMSYALRHA--PWE-YELE--IDEH-GWVNIE--HL--LYSFHEE--------kkWSELEIKDIIYVVENCD-KKRFEVDD------------------------------------------------------------------------------------------------------------------------------------------------------------------KRIRALYGHS--VP-----------------QKIIK-----------------------EPMQPP---EILYHGTAKRFL-SMIKEKG--LIPKGRQYVHLAVDS------------------------DMALQVGKRRDDHPALLIINSRDAWN-E------------GIKFYKGNEKVWLAD-----------FIDSQYIEADFIDSQ  177   Acetivibrio cellulolyticus CD2                           bacteria>firmicutes                         
256006093  273  2     SKEVAYALRHA--PWE-YGLE--LDAE-GWVDIN--QL--LSSLHEC--------ekWKKVSEHDLHVMIEKSD-KKRYEISN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRALYGHS--IP-----------------QRIIK-----------------------EQKCPP---EVLYHGTARRFV-KSIKEKG--LQPQGRQYVHLSADV------------------------ETALQVGKRRDIKPVLLIVNALEAWS-E------------GIKFYLGNDKVWLAD-----------AIPSKYIRFDAIPSK  178   Clostridium thermocellum DSM 2360                        bacteria>firmicutes                         
295093305  275  2     SKEVSYALRHA--PWE-YELE--MDEE-GWVSVE--QL--VDALNKD--------mkWIGTSEDDLLVMIDKSE-KKRHEISG------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRAFYGHS--IP-----------------MHIKK-----------------------EKMIPP---DILYHGTARRFL-SSIKING--LLPQGRQYVHLSQDI------------------------STAQSVGLRRDNKPCVLQIDAKRAWE-D------------GILFYFGNEKVWLAD-----------VIPSKYILADVIPSK  177   Coprococcus sp. ART55/1                                  bacteria>firmicutes                         
49477941   276  1     SKEVSYALRHA--QWK-YELE--LDEN-GWVSVE--QL--LHALHQS--------ieWRDVKIEDLKIMIEKSE-KKRHELKE------------------------------------------------------------------------------------------------------------------------------------------------------------------NKIRALYGHS--IP-----------------MKIVK-----------------------EEGVPP---EFLYHGTSPRFL-NSIESNG--LSPMSRQYVHLSEDI------------------------ITAELVGKRKDKHPIILEVNTGKARE-E------------GVKFYLGNEKVWLAD-----------EIPSEFILADEIPSE  180   Bacillus thuringiensis serovar konkukian str. 97-27      bacteria>firmicutes                         
304405428  278  1     SKEVSYALRHA--PWE-FELE--LDAE-GWVAVE--QL--LHSLRHQ--------aqWTSISEADLATMIDQSE-KKRHELAD------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRALYGHS--VP-----------------AKIIK-----------------------NIERPP---AVVYHGTARHLL-ETILAAG--LKPMGRQYVHLAVDQ------------------------ETAITVGKRKDSEPALLAVDAQKAWQ-D------------GIRFYRGNHSIWLAD-----------QVPPIYILADQVPPI  179   Paenibacillus curdlanolyticus YK9                        bacteria>firmicutes                         
325108247  281  3     SRAMSHALRHE--PWV-YELE--LDEE-GWTSTE--RL--LSALRKQ-------kskWRNVTERDFVRLMESAT-KQRYEMAD------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIRAFYGHS--VT-----------------GLLKK-----------------------TPAEPP---AVLYHGTSPEVV-EFILAEG--LRPMARQFVHLSTEI------------------------VTAKEVGRRKCKVPVILQIDSPLAVQ-Q------------GSCFYLGNEMVWLAD-----------KIPEMVWLADKIPGN  178   Planctomyces brasiliensis DSM 5305                       bacteria>planctomycetes                     
339009751  282  1     SKEISYALRHA--PHE-YELE--LDEY-GWVQTE--QL--LHSLHEQ--------pvWRNVSEKDLQVMISQFD-KKRFEMEN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKMRALYGHS--TA-----------------KRVLK-----------------------EESEPP---EFLYHGTPKRFV-SLILEQG--LLPKGRQYVHLSEEI------------------------QTAKQVGKRRDTHPTILKIEAKKAWA-N------------KVTFYHGNEMVWLAD-----------KIDRQYILADKIDRQ  176   Brevibacillus laterosporus LMG 15441                     bacteria>firmicutes                         
319936601  285  1     GKEISYVLRHH--PEK-YNLD--IDNE-GWVDVG--DL--LNALESR----------FGLLKEEDIVALMQQSE-KERYELKN------------------------------------------------------------------------------------------------------------------------------------------------------------------HRIRAYYGHS--FS-----------------KKIMK-----------------------QRNIPP---KVLYHGTARRFV-SSILTTG--LQPMSRQYVHLSQDV------------------------ETAKQVGMRHDTQPVILMINAQSAFQ-D------------GVAFYLGNEKVWLSE-----------TIPPQYIEERKQPPQ  175   Coprobacillus sp. 29_1                                   bacteria>firmicutes                         
332361966  286  6     SREVSYILRHN--PDK-YGIK--LDSE-GWCSVD--DL--IHNLSET--------plWKGLTRDDLETMIELSD-KKRHEIKG------------------------------------------------------------------------------------------------------------------------------------------------------------------EKIRAFYGHS--IK-----------------DKLSK-----------------------TANKPP---KVLYHGTVQRFL-NQILQTG--LIPKERQYVHLSSDV------------------------STAKQVALRRDDRAIILEVAAQSAWE-N------------GVKFYIGNEDIWLSE-----------PIPSEYILSEPIPSE  177   Streptococcus sanguinis SK49                             bacteria>firmicutes                         
125717421  287  3     SREISYILRHN--PLK-YNLT--LDKE-GWADIN--DL--LQKLNAR--------seWNGLSKKDLEKMIASSD-KKRHEIQS------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRAFYGHS--LK-----------------EKVQK-----------------------SPCQPP---NVLYHGTVEKFV-DSILEKG--LITKERQYVHLSTTP------------------------ETAIKVALRRDKKAIILKIDAQKAWD-S------------GIKFYLGNEDIWLSE-----------PIASKFISFEPIASK  179   Streptococcus sanguinis SK36                             bacteria>firmicutes                         
227893699  291  14    SKKMSYCLRHN--PGK-YGLK--LDEY-GFVDLQ--EF--LNAMNRI-------hqhFPKLTEMKIREIMHNSD-KERFEIKN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKICALYGHS--LP-----------------GIIKR-----------------------KKAIPP---KVLYHGTAHRFL-TSIEREG--LLPMGRQYVHLSTDI------------------------AMAESVGKRRDHHPAILLVNAEKAHK-D------------GIDFYIGNDEVWLCD-----------CVPSKYLLCDCVPSK  184   Lactobacillus ultunensis DSM 16047                       bacteria>firmicutes                         
298245737  293  2     SKTMAYVLRHD--PQS-HGLT--LDAE-GWVSLK--DL--LAALRQQ-------rsyWATLKEADLLAVLEQSE-KQRFEVRN------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIRAYYGHS--VP-----------------TKVEK-----------------------QPVTPP---EILYHGTTPQAA-NLIKGRG--LSPMKRQYVHLSADE------------------------ETAMVVARRRTNHPIILKVHARKAEA-N------------GVRFYLGNDMVWLAE-----------PIPSDYIQFEPIPSD  181   Ktedonobacter racemifer DSM 44963                        bacteria>chloroflexi                        
226313333  296  6     RKRLLSILRQN--SEA-FQLY--YDTY-GYTPVE--PL--LEYLHTL--------kgCAYITRQDLHQVVEFDP-ERSIEWDGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------SLIRVTYGF---LP------------------SIAKs--------------------rlMEIVPP---DVLYYGTHRKLL-KQVLTGG--LLPIASEYVQLADRP---------------------------EHIGEPTDTLR-LVTVNAKEAHE-A------------GICFYRVGEHYCLSD-----------AVPSSYLQLDAVPSS  180   Brevibacillus brevis NBRC 100599                         bacteria>firmicutes                         
312142649  297  5     SKTLSYILRHH--PES-FDLK--LAAD-ASVETD--EL--LNSLKNK----------FKKITKDDLIKVVEADP-KGRFSFLDEq----------------------------------------------------------------------------------------------------------------------------------------------------------------KRIRANYGHS--IE------------------GVNP---------------------eyEAVKPP---EFLYHGTTPEAK-NKILAEG--IKPMGRNYVHLSVNI------------------------KEAKKVAQRRTNNELIFKIRALKAYQ-A------------GQEFYKTAENIYLTD-----------QIAAKYLFFDQIAAK  179   Halanaerobium hydrogeniformans                           bacteria>firmicutes                         
116748284  300  3     ARMLSYIGRHS--PGE-FGLY--WNPD-GTMPWK--EF--YWALQED--------eaLRFVRESHVREIALQGL-ELPFSLEN------------------------------------------------------------------------------------------------------------------------------------------------------------------NRLRLIGPAA--PP-------------------EYP-----------------------VSEFLP---GRLFYACRRAHL-EVIRLRG--LQASGRPYVLLCTER------------------------EQAVRIAKRREAEPIVIEIKAEEARA-A------------GTLFRKAGATVYLVE-----------CVAADHLVFPCVAAD  177   Syntrophobacter fumaroxidans MPOB                        bacteria>proteobacteria>deltaproteobacteria 
328952864  303  12    ARLLRYILCHH--PDE-FGLV--LDKS-GRLAVK--EL--LRALGQE--------egWRFVRRSHLEEVVNLIN-PGDFELDQ------------------------------------------------------------------------------------------------------------------------------------------------------------------TYIRALHPQP--AE----------LRSQ-------------------------------EAAWPP---PLLYRAITANSH-HAVAERG--LQPPSGGELVLADNQ------------------------ELAKRLGQRRDPQAIMVIVQAQAAAK-R------------GVNFFSYGPKLYLSD-----------AIAPEYLQLPAIAPE  183   Desulfobacca acetoxidans DSM 11109                       bacteria>proteobacteria>deltaproteobacteria 
301058276  304  1     --MLTYVLAYR--PDE-FGLI--PSEE-GFVRYK--EL--LKALHEE--------egWRHVRQSHINEMLMGED-RALFETEG------------------------------------------------------------------------------------------------------------------------------------------------------------------DRIRSRKRHW--VM-----------DDQ-------------------------------SDHPLP---GLLYTSVRKRAH-PVAMEKG--LKAETGSHIALSPHR------------------------EMALRMGRRRDQHPVLLEIPAMLAEK-K------------G-MRIFSFGVLFLTP-----------EIPAHCISGPEIPAH  168   delta proteobacterium NaphS2                             bacteria>proteobacteria>deltaproteobacteria 
308270161  306  5     SKFVSYILERK--PDE-FGLV--PDEN-GYIKIK--SL--LLALNEE--------dgYKFVRRHHIDDILSSIP-DSQLEIND------------------------------------------------------------------------------------------------------------------------------------------------------------------DLIRSKYRDN--LP-----------KPT-------------------------------VSENPP---KLLYTCVRKKAY-SFALEKG--IFPVGNKKVVLSPAK------------------------EMAERMGKRFSPLPVVLTVNVQKALE-A------------GVIFHNSSE-LYTAD-----------AIPADCFTGPAIPAD  180   uncultured Desulfobacterium sp.                          bacteria>proteobacteria>deltaproteobacteria 
158521555  307  3     ARVIAYMLGQA--PAE-FGLV--PDAS-GYVKIK--EL--IKALHEE--------egWRHVRASMLNTLVLTLD-DVPFEIQD------------------------------------------------------------------------------------------------------------------------------------------------------------------DKIRTKDQTP--GA-----------PAE-------------------------------PVSGLP---KLLYTCVRQRAH-GRVAQAG--ITPSFAEAVVLSPDR------------------------EMAQRIGKRRDPDPVVLVVETRAALE-N------------GVAFRQTEGDLFLAD-----------FIPVDLFLADFIPVG  175   Desulfococcus oleovorans Hxd3                            bacteria>proteobacteria>deltaproteobacteria 
302344076  301  6     ARMLRYILGVC--PAE-LALL--PDAE-GWVRQK--DL--LAALHGE--------dgWKHVRQTMLTDMADRLA-SDVFEADD------------------------------------------------------------------------------------------------------------------------------------------------------------------TRIRCRQRSY--AP-------------------------------------------pnPEAKPP---AHLYYGARRRAY-PVIRERG--LDADDGPGLIVCADS------------------------QRALAIGRRRDAEPVLVTIQARLAQE-N------------GIQARLAQENGAALAAWGEEGLFVA-QWIDAQFLMGPPLPD  160   Desulfarculus baarsii DSM 2075                           bacteria>proteobacteria>deltaproteobacteria 
218780694  305  11    NKFLAYALGRR--PDE-FGLF--PDED-GWVKVK--DL--VRALSEE--------dgWKHVNKAHIKEVAYTLE-DPAIEYEHEe----------------------------------------------------------------------------------------------------------------------------------------------------------------GIVRAVEWDP--SL----------YYTG-------------------------------VPEDLP---KLLYVGARNKTY-PEIDKKG--IFPVGAPFVILCRDE------------------------DMAFRIGKRRDGNPIVLTVNTAMAQE-L------------GVVFAMAQELGVVFEQAGEVLLTAE-FIPKGCFTGPPLPKV  163   Desulfatibacillum alkenivorans AK-01                     bacteria>proteobacteria>deltaproteobacteria 
consensus  100  %     ........................................................................................................................................................................................................................................................p...............................................................................h...s..l.......l.h............................................h................................................................
consensus  95   %     ...hs..LRH.........h........Ga.......h..h........................l..hh..s..K.Ra.h......................................................................................................................................................................lpA.bGHo............................................................hhaus....h...l...G..l....p..lHhs.................................u.b......hh.l........................h..s...l..s...........................
consensus  90   %     .+.hs.hLRH...s.....l...hp...Gah.h....l..l....................p...l..hh..s..K.Ra.h.....................................................................................................................................................................bI+A.bGHo..h...................................................s.....hhHGT....h...I..pG..l....R..lHhs.s..............................su.R.....hhh.l....h................s..hb.s.p.lhLs...........................
consensus  85   %     u+.hu.hLRH...s.....l...hp...Gah.l....l..l...................hs...l..ll.ps..K.Ra.h.....................................................................................................................................................................bIRA.bGHo..h...................................................s.....lhHGT..p.h...Ib.pG..l....RpalHhu.s..............................sG.R..s..hhl.lp...h................G..hh.u.s.lhLs...........................
consensus  80   %     S+.lobhLRH...s....sl...hs...Gah.lp...l..l...................hsb..l..lV.pss.KpRa.hp....................................................................................................................................................................bIRA.bGHS..l............p......................................P.....lhHGT..p.h...Ib.pG..L....RpalHhu.s...........................s..sG.Rp.s..lll.lps..h................G..ha.u.s.VhLs...........................
consensus  75   %     S+.lSblLRH...s.p.bslp..hc.p.Gah.lp..pl..l.....p.............hsb..lpplV.pss.KpRa.hp....................................................................................................................................................................bIRAsQGHS..l............p..h...................................P.....lhHGT..p.h...IbppG..L..bpRpalHhu.s...........................u..sG.Rp.sp.lll.lss..h...p............Gh.aabu.NsVhLsp............ls............
consensus  70   %     SK.LShlLRH...s.p.hGlp..lc.p.Gahplp..pl..l...p.p.............hsbpplpplV.pss.KpRaphp....................................................................................................................................................................bIRAsQGHS..lp...........p..h.................................p.P.....lhHGT..p.h...IbppG..Lp.bpRpaVHhuss.........................p.u..sGbRp.spslllblcs.ph...s............Gh.FabupNsVhLsp............ls..hh........
PDB:1wfxA  -    -     HHHHHHHHHH--------------------EEHH--HH--HHHHHHH--------------HHHHHHHHHHHH----EEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEEE--------------------------------------------------------------EEEEE-------------------------EEEEEHH------------------------HHHHHHHH-----EEEEEEEHHHHHH-H---------------------EEEEE-----------------EEEEEEEE--
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    Multiple Sequence Alignment of the NEURL4-like family 
    ALIGN                                          -------EE---EEEEE------EEEEE-------------------------------------------------EEEE---HHH-----H-HHHHHH--------HHHEEEEEEE-------------------------------------------------------------EEE-----HHHHHH----
HMM                                            --EE-EEEE---EEEEEE---EEEEEEEH-----------------EEEEE--------------------------EEEEEEEEEE--------EEEEE-------EEEEEEEEEEEE----EEEEE---------------------------------------------------EEEEE----EEEEEEEE-
FREQ                                           --------E---EEEE------HEEEEHH-------------------------------------------------EEE-----H----------------------EEEEEEEEE------------------------------------------------------------EEEEE----HHHHHHHH--
PSSM                                           ------------EEEE--------HHHHH------------------------------------------------EEEE----E-----------EE--------EEEEEEEEEEE-----EEEE---------------------------------------------------EEEEE------EE------
FINAL                                          --------E---EEEEE------HHHHHH------------------------------------------------EEEE---EEE----------EEE-------EEEEEEEEEEE------EEE---------------------------------------------------EEEEE-----EEEEEEEE-
NEURL4_Hsap_53829370                     1408  EAGTLTKKW---HMAYHGSNVAAVRRVLD-RGELGAGTASILSCRPLKGEPGVGFEEPGENCAPPREE------QPPPVLLSPSLQYAGAETLASKVQFRDPKSQRTHQAQVAFQVCVR--PGSYTPGP-------------------------------PSAALGEPPDPHFSPAE-LEWVTKEKGATLLCALLVR  1560  9606    Homo sapiens                        eukaryota>metazoa>chordata>vertebrata               
Neurl4_Mmus_29748106                      178  EAGTLTKKW---HMAYHGSSVAVVRRVLD-RGELGAGTTSILSCRPLKGEPGVGFEEPGENCAPPREE------QPPPVLLSPSLQYAGAEMLASKVQFRDPKSQRTHQAQVAFQVCVR--PGSYTPGP-------------------------------PSAALRELPDQHFSPSE-LEWVTKEKGATLLYALLVR   330  10090   Mus musculus                        eukaryota>metazoa>chordata>vertebrata               
GSTEN:00009647:G:001_Tnig_47211351       1132  EVSTALKKW---HIAYHGTGVGTLRRTLD-HSQLLPGTSSVFSVSPVKTEGPNDYGEPEENSAPGRE--------VPRVRLSPTMRYSGMETFAPKVKFQDPRSRRCHQAQVAFQVCIR--PGSYKVGA-------------------------------QSVGHSETLDPRFSNAE-IEWITKEQGGTLLYGLLIR  1282  99883   Tetraodon nigroviridis              eukaryota>metazoa>chordata>vertebrata>actinopterygii
LOC581240_Spur_115948408                  208  LNVF--ESW---HVAYHGTSVGSVRKILD-RGTLLPPGDTSL-GRLYQPET-LGSS-LNKPSLVPD---------LMQIFVSPTLKYAGCDIFSHRCKFIDSLTQKEHFARVAFQVRIR--PGCYTAGP-------------------------------QSIGANHTIDPYIENSR-IEWTTKETSSIVLCALLIH   351  7668    Strongylocentrotus purpuratus       eukaryota>metazoa>echinodermata                     
BRAFLDRAFT_74056_Bflo_260810360          1003  SQRNVFTDW---HRGYHGTPAGTVKKILQSSSQLLLPGDVT-----PGGEKMGPGKGKGFD--------------SVQVFLSPSIKYSGRDLYAKPMRIKDNTDGKEYTARVAFQVCIR--PGCYGIMHETV----------------------------GASRKGETIDPLFSNKE-LEWFTKERGVHALYGLLVK  1146  7739    Branchiostoma floridae              eukaryota>metazoa>chordata                          
EHI_155600_Ehis_67480865                  253  GFGE--EEW-----AFHGSSIDSIQGIIK-EGFKLPD-DV---------DAVKLDS----------------GYFGHGIYLTYFSDYA--LFYSNS-----------RNSNQMVLCQIL--PGNVFKCKKRM----------------------------DGKKCQKGYDSHFSPKG-NEIVIFDPKHILPKYIIEF   371  294381  Entamoeba histolytica HM-1:IMSS     eukaryota>amoebozoa>entamoebidae                    
BRAFLDRAFT_90934_Bflo_260831601           778  TALGVFQKW---HVAFHGTTVGALESILN-TGDLIKAGDKTMEGSRLSERDGHYKDSWKPE-----------GFDTKQVFVSPSIHYAGLPAYAKPSSFT--HRGTTYEAKVALQLYIK--PGSYKVA--------------------------------ASTVARKNVDKKFSDSE-IEWSTDRHGVIIVYGLLVK   922  7739    Branchiostoma floridae              eukaryota>metazoa>chordata                          
cgd5_910_Cpar_66357730                    115  EEEN-VKNW---DLSYHGTTHKAIKSILK-DKRLVIPNNKTVHIRKGHI------------------------PNQYFIFTSPSLLYASFGLYSAPFKIKE----SKKWWQIVVEIVQK--PNSYVKEWE------------------------------TSGLGNYEFDKYIGNYE-LEWKSDQEMGNLIKAVLVR   245  353152  Cryptosporidium parvum Iowa II      eukaryota>alveolata>apicomplexa                     
BBOV_III011060_Bbov_156089639              70  TYHP-INYI---GIGLHNNKEDTVDNETD-SGASMEPPDNVFSIPVITNDAT---------------------YFKQHIFASPSCMYATLPEMASALDFE----GLNVGLRIVIEVLVK--PASYVTGPA------------------------------SVKNIKNGFDCCFDNQN-IEWFVKNLDHIVPHRLLFR   203  484906  Babesia bovis T2Bo                  eukaryota>alveolata>apicomplexa                     
Phum_PHUM397400_Phum_242016155           1565  TEKI--DTW---QVAFYGTRPDAIRRILD-HGELVLPCLLGMERTRVKAKEDETD--------------------SSHIVFSPSIKYAACDYFVTKFRFYDSRTKNKTEATLAFQILVQ--PGSYKVGPP------------------------------SVDVSKEIPDTRFERDA-TEWVTKERGATTLSALLIK  1702  121224  Pediculus humanus corporis          eukaryota>metazoa>hexapoda                          
PTSG_01796_Ssp._326433251                 405  THARATKLWETSHVCYHGTSIGALKPIIE-GGEILPPGEVNVTHTHIIPRDDEDNPREGRLPTVYTTPAHNLDRIHKSVFVSPSVAYASSSTYAERYYW----PGGRQFLVPVLQTRIR--PDTYDVR--------------------------------SSTLRDTPHDPCYSADE-MEWYTPRRGVIQIYGLLLK   561  946362  Salpingoeca sp. ATCC 50818          eukaryota>choanoflagellida                          
TP02_0033_Tpar_71029920                   104  NHFS--DNF---SIKHFLVKIIRSPRLSD-DDFSQLRNHINGASDPQSSVTKQSD--------PSHPDPNISNTIGEGLMVTPSCMYATKQEISSILTFEE----LDVKLQILIQIKAK--PGSYTVSP-------------------------------NSIKLNDNFDSCFPNSE-IEWYVKNVDDIIAERLLFK   248  333668  Theileria parva strain Muguga       eukaryota>alveolata>apicomplexa                     
TA12305_Tann_84995898                     103  RHFT--DNF---SIKHFLLKIIRNPRLSD-DDFSKFRNYITGNSDLSSAVINNKD--------QPPADAATTDHKDEGLMITPSCMYATKPEISSILTFEE----LDVKLQILIQIKTK--PDSYTTSP-------------------------------NSITLNENFDSCFPNSE-IEWYVKNVDDIIAERLLFK   247  353154  Theileria annulata strain Ankara    eukaryota>alveolata>apicomplexa                     
TRIADDRAFT_57456_Tadh_196007734          1231  NVNL--NEW---YIGYYPSTVGNVRQILD-NRILATGNEDDYDRDISVST--------------------------NICHIQEHVEI---SQF-RHEVF--------GLVSVAFEVYIK--PDATTIA----------------------------------------DIEGTGDQCSMLTFKHSPRNMILSALLIK  1341  10228   Trichoplax adhaerens                eukaryota>metazoa>placozoa                          
SINV_00048_Sinv_322786335                1518  QSTT--DKW---HVAFYSIRLDAIRLILD-RGELMTK-EQLDVSNLTSGT-KSED-------------------QNPQVMFSPAVKYAASDEFTRKYPYIDMQLNKKLNASTAFQLLVR--PGSYTTFP------------------------------------KVFRDENERYCESVKWATKEAGATVIVALLVH  1649  13686   Solenopsis invicta                  eukaryota>metazoa>hexapoda                          
LOC100117587_Nvit_345484523              1620  QSTT--DKW---HVAFYGTRIGTVRWILD-RGELLTK-EQLDTDSLTTGT-STED-------------------QNPQVVFSPNIKCASSEEFTKQYSYIDTQLNKKVNASTAFQLLVR--PGSYTTS--------------------------------------SKKDGLDSQLECIEWATKETGATVIIALLIH  1749  7425    Nasonia vitripennis                 eukaryota>metazoa>hexapoda                          
EAI_14437_Hsal_307195422                 1616  QSTT--DKW---HVAFYGIRLDAIRLILD-RGELMTK-EQLDMSNLAMSI-KSED-------------------QNPQVSFSPSIKYAVSDEFTRKYPYIDTQSNKKLNVSTAFQLLVR--PGSYTISP-------------------------------------GDKDSIDLHCESCKWATKEAGATVIVALLVK  1745  610380  Harpegnathos saltator               eukaryota>metazoa>hexapoda                          
blue_Amel_328784754                      1583  QNAI--DKW---HVAFYGIRLDAIRLILD-TGELIPK-EQLDLSNLTMNI-KMED-------------------QNPQVVFSPSIKYAASEEFTKKYPYIDTESNEKLNASTAFQLLVR--PGSYTINS-------------------------------------SSKDSDDSQFQSVKWATKEAGATVIMALLIR  1712  7460    Apis mellifera                      eukaryota>metazoa>hexapoda                          
blue_Tcas_270008234                      1288  NTAT--DKW---HTAFYVCKVGAVRCILD-KGQPLTK-GQAQWCNLVAQ--KEDD---------------------VQVVFYPTLQNCKTSGYKTNN----------RVVHAAFQLLVK--PSAYSVSR-----------------------------------------------DPPEWSTKETGAIVLHSLLIQ  1395  7070    Tribolium castaneum                 eukaryota>metazoa>hexapoda                          
blue_Dmel_78214301                       1604  VHFDLNGDW---LPFYYMTRVDKIRAILD-RGQPLPL-ETDPDEEPAAAA-LKDE-----------------PGTRLELYYSPNATVIEPVLPQHHFAS-EQ---GLHRISTSFEVYVR--RQSISGVTTGKAAAEAKRRSLGSTDHDHGGTGQGADGVGVTPSATLNESSVHLLND-LCWFTKEAGACIINALIIH  1769  7227    Drosophila melanogaster             eukaryota>metazoa>hexapoda                          
AgaP_AGAP011965_Agam_158300710           1597  TADE--FVW---TTAYYNTRVDKIRSVLD-HGQPLPI-ETGQLLPE-SST-LNDN---------------FIPGTHILLRSVPDAAEPASNATSTSSHF--------FHIKTAFEVRVR--AQSLSAVDHSG-AGEGLNASTGGAGV--TGTGGCTSGVSTVPTA--GGVASGTDFTFRSWTTKEADACVLTALLIH  1754  180454  Anopheles gambiae str. PEST         eukaryota>metazoa>hexapoda                          
DAPPUDRAFT_309455_Dpul_321459414         1336  PGIN--EKW---QTAYHQTRPCVVRRILD-EGHLLSP-DLNVWQRTKAAR-RSSK--------------GNDGESNGQLLFSPTLQ-PAS-LAPIAELY-DPILKKNQRGQVVLQVLVQ--PGSYKVRRATSPLNGPAPTVPTANTVGSVTCSPDPTHQQQLLNPPADTTAITDEDPAILWYTKERGAAIVQALLIS  1504  6669    Daphnia pulex                       eukaryota>metazoa>crustacea                         
NEMVEDRAFT_v1g131035_Nvec_156360568       144  SQVP--REW---PVAYHGTNFTNANSILQ-KGLKPGD----------------------------------RALYGKGVYTSPSLQMV--EKYYAQEFKYE-----GKSYKIVFQSRVN--PDQSNGHL-------------------------------KIIPASKTGVGADYWLSPKQNVRKGPHDVRPYGILIK   260  45351   Nematostella vectensis              eukaryota>metazoa>cnidaria                          
TTHERM_00581840_Tthe_118371452            890  DTSD--KTW---IVLFHGNKKLSTQELIE-EGYKQGG-------------------LQQYQGHQCRFG---RGLIKQGIYFYEKIQDA--EKHADTFFIND------KQYNLLFQCRVN--PKTVKSP----------------------------------------------INKPSCYVANDPKDVRPYRILIK  1002  5911    Tetrahymena thermophila             eukaryota>alveolata>ciliophora                      
TTHERM_00621420_Tthe_118369526           1032  YNSK--EQW---IVLYHGTSIQGVEGITK-EGFRLGQ-------------------HHKYAGAKCRITGKIIEKSSKCVYLTDDANVA--GRYSTPFEI------KGKAYQMVFQCRVN--PKVVRSP------------------------------------------KEKPDYYIIEESGQPQQNIRPYRILLK  1151  5911    Tetrahymena thermophila             eukaryota>alveolata>ciliophora                      
ubqP_Ddis_66808359                        209  CNGP--NEW---LVSYHGTKEESCNPIAM-EGYKLSS--------------------------------CSGFAFGVGIYSTPSIDIA--KTYGRTFKK-D-----NCHYVIVFQNRVN--PKTVIKI-----------------------------------------------DNIQYWISPNDADIRPYGVCIK   310  352472  Dictyostelium discoideum AX4        eukaryota>amoebozoa>mycetozoa>dictyosteliida        
ubqK_Ddis_66813768                        205  NNTD--GEW---PVSYHGTGKHESKSIAE-KGYDLSK--------------------------------GKRFLYGRGVYSTPSIKCA--EAYATSFIH-E-----GSTYRVVFQNRVN--PKTLIKIP------------------------------------------KSQTNFEEYWISPKDEDIRPYSICIK   311  352472  Dictyostelium discoideum AX4        eukaryota>amoebozoa>mycetozoa>dictyosteliida        
ubqM_Ddis_66813772                        165  NNVD--GEW---PVSYHGTGKHESKSIAE-KGYDLSK--------------------------------GKTFKFGYGIYSTPSIKCA--ETYANSFEY-E-----GCTYLVVLQNRVN--PKTLIKIP------------------------------------------KSQTNDEEYWVSPKDEDIRPYCICIK   271  352472  Dictyostelium discoideum AX4        eukaryota>amoebozoa>mycetozoa>dictyosteliida        
GSPATT00016112001_Ptet_145525701          190  NGNQ--NEW---RIMYHGTKQHFVSSIVK-TNLKPGSNN------SYCDQLCFDE-------------FNNQVKVGNGIYFSDKIEVCF--GYTNYTQI------GNKQFAVIFMSRVN--PREIRQ--------------------------------------------SKEMIAQRFFVINNSEDVRPYRILLH   307  412030  Paramecium tetraurelia strain d4-2  eukaryota>alveolata>ciliophora                      
EDI_044520_Edis_167386548                 202  SNVT--GEW---AVSFHGSNCSKFTEIVQ-WGDKLGVSN----------------------------------VGGMSVFCTPDFRVA--LQHSDVVT--DP--QTGKKYKVIFQNRVK--PSSIIRA-------------------------------------------SKVGGPNNFWYITNPSDVRAYSICLF   307  370354  Entamoeba dispar SAW760             eukaryota>amoebozoa>entamoebidae                    
EHI_013080_Ehis_67481957                  201  SNRD--EEW---PVSFHGSNCSKFTEIVQ-WGDKLGVSG----------------------------------VGGMAVFCTPDFRIA--LQHSDVVT--DP--QTGRKYKVIFQNRVR--RSSIIRA-------------------------------------------SNVGGPDNFWYITNPSDVRAYSICLF   306  294381  Entamoeba histolytica HM-1:IMSS     eukaryota>amoebozoa>entamoebidae                    
ubqP_Ppal_281212323                       218  QSAP--GEW---IVSYHGTTTDEFGSMSN-DGYRISKSE--------------------------------KKDFNQGIYSTPSIKLA--ERFAQKFQF-D-----GAQYLVILQNRVN--PNTVEKL-----------------------------------------------GNGTYYLSPNENDVIPYGICIK   319  670386  Polysphondylium pallidum PN500      eukaryota>amoebozoa>mycetozoa>dictyosteliida        
GSPATT00020219001_Ptet_145536409          315  DGNK--DEW---RILFHGTKNENVNDIIV-SSLKEGWRS------LYEDDLCKDE-------------FGNNVPVGKGIYFSDKFTVCVDKGYAKPIQV------NNKSFSAIFMTRVN--PKKIRQS--------------------------------------------DRMKQERYFLVNRSADVRQYRVLIY   434  412030  Paramecium tetraurelia strain d4-2  eukaryota>alveolata>ciliophora                      
LOC100206592_Hmag_221109790               223  TDVP--GEW---PVSYHGTGVNEAKSIAE-DGYNLTK--------------------------------GKRFAFGRGVYSTPNIKVA--EKYALNFMH------KNKQYAVVLQNRVN--PTTLLKIS------------------------------------------ADHTKIGEYWISPSDKDIRPYGVCIR   329  6085    Hydra magnipapillata                eukaryota>metazoa>cnidaria                          
LOC100200953_Hmag_221109705               214  SNNP--GEW---PVSYHGTGVYQDKTFAM-NGYDLTK--------------------------------GKMFAFGRGVYSTPNIKVA--EKYAIKFLY------KNEHYAVILQNRVN--PTTLVKIS------------------------------------------ADRIGEGEYWISPSDKDIRPYGVCIR   320  6085    Hydra magnipapillata                eukaryota>metazoa>cnidaria                          
DAPPUDRAFT_48503_Dpul_321472004            97  SSAE--DEW---PVSYHGTSYHNGLSIAS-EGFKLSK--------------------------------GTRFRHGKGIYSTPEIEVA----AQYAE---EATV-NGKTYKVVMQNRVN--PKNLEKV------------------------------------------DKAETGVGEYWISPSDEDIRPYGFCIR   203  6669    Daphnia pulex                       eukaryota>metazoa>crustacea                         
LOC100639670_Aque_340383127               195  ESSK--GEW---PVSYNGTTKEGTMTIAA-KGYGEDK--------------------------------LARENFGRGFYSTPSVEIA--ADFARRFDHTD-----GKRYEAIIQNRVNLNPGHSEIIP-----------------------------------------VEKTRHGAEYYLTYSSDDLRPYGICIR   305  400682  Amphimedon queenslandica            eukaryota>metazoa                                   
LOC100639047_Aque_340386726               249  ESSK--GEW---PVSYHGTGREEAKGIAV-EGYD-SKRW------------------------------REKCYHGKGHYSTPDIEVA--AKYYTK-PF-D---QNGKKYEVVMQNRVNLSPGHTIIIP-----------------------------------------KEKTRAGAEYYLTYSSDDLRPYGICIR   360  400682  Amphimedon queenslandica            eukaryota>metazoa
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    Multiple Sequence Alignment of polymorphic toxins 
    134103275 ------------------------------RARV-AH-PDRLRGVSDEEISALLTYTYDHGSCYALNKSMREG-TPDREEMEP-YRRLLTSALNK--IRAN----DEAMG----V-PATQLVERKISVSPESMAGFREKYGNSGATVREEAFMSGTEVE---SRH--VPDGHREGEDYLVTMQVWNGTNVNIASLSR---LP-GEGEVLRIGDGEFRVARYEENGLKVNV--VLEEVGQ-----
148546317 EKTVAAAPKKLMSLRDAVGKDMAERWIAEGRARADIRAPELSRLLSDDQIGALYGYSTNDV-YKAYNQALRE--GTATPGIKA-FAEHATEGLAR--LPRYL-GAETYRG-TD-L-PQHVLNRMQM-----------------GAVETDMAFFS---SS---ATT--PFSGN-------TQMVVRGVSGKDISFLTQ---I--PEAEVLYPPGTSFRVLNRIEQGPTTRL--LLEE--------
157371257 -----------------------------ARANAEKNNAQLSTLLTDDQIGAIYGYTTNEG-YTALNPALRGQ-TPLTPELEA-FTGHVTDGLNK--LPAYN-G-ETYRG-TT-L-PAHILEQNQI-----------------GGTVSDGGFMS---TS---AKT--PFDGD-------VSISVRGNSGKQIDFLSK---YK-NEAEVLYPPNTRFEVINRIEQNGTTHLL-------------
15893630  -----------------------------ANEWGSQYYDNWLKSLNDSERNAIRQYTGND--YKKINNYLRGV-NDSLDGIDPKIIEDIKSGLKKASVPHDM---KVYRG-TD-LNPLRNLIDVGK----DGSLDFSSLV---GKTFKDDGFMS-TALV---KES--SFDYM----N--VSWEINVPKGTEAAYVSKISYFP-DEAELLLNHGQEM-IIKEATVGSDGKLNIVLDLNLK-----
167033761 --------------------------------------------LTDDQIGALHGYTTNEG-YQWINPALRGQ-TPLSPQMEA-FVTHANEGLAK--LPSYTLG-DTFRG-TT-L-PEDVMSRMQV-----------------GLPTSDAAFLS---TS---ADRALAFNGN-------VKMTLQGVTGKDISFLSG---H--REAEVLFGPGTRFNVVDRVDNGS------------------
16802114  ------------------------------EKWGIDGFSVWRNSLSSREIQAIRDYTDIWH-YGNMNGYLRGSVEKLAPDNAE-RIKNLSSALEKAELPDNI---ILYRG----T-SSEILDNFLD----LKNLNYQNLV---GKTIEEKGFMS-TTTI---SNQ--TFSGN-------VTMKINAPKGSKGAYLAHFSETP-EEAEVLFNIGQKMLIKEVTELNGKIE--IIVDLL-------
221200352 --------------KEKWGSKDVEDALA-----AKRGNAVLDKLLTDNEYLAIRGYTSNL--YEEINPALRAG---NPGEWGR-LTAEASNGLTK--LADN--G-YAHVG--------DVVRNLRL-----SNEQVEQLFPV-GGVFQDKAFLS-TTSD---LDG--VFPGK-------VTMNITSRSGVSVSSLSE---YP-REAEVLFKPDTPFKVLDRTHDPAKGSWNITLEE--------
228992027 -----------------------------AHEWGSKHFDNWIESLTESERSAIRQYTGDD--YRKINNYLRGI-ADSLNDVESSVIDNIKSGLNKASVPYDI---QVYRG-TD-LKPFKNLYKIDD----EGKIVVDSLV---GKTVKDNGFVS-TAMV---KES--SFDHM----N--VSWEINVPKGANAAYVGKISYIP-TEAELLFNSGQEM-VIKSANVDSDGKIHLILDLI-------
229007965 -----------------------------------------------------------------------------------------------------M---QVYRG-TD-IKPFKDLIELGK----DGRSDFESLI---NKTIKDDGFVS-TAIL---KAS--SFDYM----E--VSWEINVPKGASAAYVGKISQFS-NEAELLLNASHEM-IIKSVNVERNGKLHVTLDLILKK----
255030176 ------------------------------EKWGIDGFSVWRNSLSSREIQAIRDYTDIWH-YGNMNGYLRGSVEKLAPDNAE-RIKNLSSALEKAELPDNI---ILYRG----T-SSEILDNFLD----LKNLNYQNLV---GKTIEEKGFMS-TTTI---SNQ--TFSGN-------VTMKINAPKGSKGAYLAHFSETP-EEAEVLFNIGQKMLIKEVTELNGKIE--IIVDLL-------
291007932 --------------------------------RARVAHPDRLRGVSDEEISALLTYTYDHGSCYALNKSMREG-TPDREEMEP-YRRLLTSALNK--IRAN----DEAMG----V-PATQLVERKISVSPESMAGFREKYGNSGATVREEAFMSGTEVE---SRH--VPDGHREGEDYLVTMQVWNGTNVNIASLSR---LP-GEGEVLRIGDGEFRVARYEENGLKVN--VVLEEVGQ-----
304399359 -------------------------------------------MLTDDQVGALYGYTTNEG-YTALNPALRGQ-TPLTPELEA-FAAHAKDGLSK--LPPNK-G-LSYRGINS-L-PEEILAKNQP-----------------GNIVSDGAFMS---TS---SNE--PFQGN-------ILIKVNGASGRDVAFLSE---YP-LEAEVLYPPDTQFKV--------------------------
313625682 ------------------------------EKWGIDGFSVWRNSLSSREIQAIRDYTDIWH-YGNMNGYLRGSVEKLAPDNAE-RIKNLSSALEKAELPDNI---ILYRG----T-SSEILDNFLD----LKNLNYQNLV---GKTIEEKGFMS-TTTI---SNQ--TFSGN-------VTMKINAPKGSKGAYLAHFSETP-EEAEVLFNIGQKMLIKEVTELNGKIE--IIVDLL-------
325518063 --------------KDKWGSKDVADALE-----AKRGNPVLDKLLTDNEYLAIRGYTSNL--YEEINPALRAG---NPGEWGR-LTTEASNGLTK--LADN--G-YAHVG--------DVVRNLRL-----TNEQVEQLFPV-GGVFQDKAFLS-TTSD---LDG--VFPGK-------VTMNISSRSGVSVSSLSE---YP-REAEVLFKPDTPFKVLDRTHDAANGSWNITLEEL-------
354724236 --------------AEAVGKQRAENWISRGRELADNRDPALSALLSDEQVGALYGYTTDPG-YQMVNPALRGM-KPMTKEMEA-FTQHINDGLDQ--LPVYN-G-ETFRG-MNSL-PSNILEGYTP-----------------GKTVIDPAFVS---TD---INQ--GFSGP-------IQMRIEGVSGRKIDFLSE---FNATETEVLFKPNTTFEVISRSD---------------------
358463913 -------------------------------------------SFTNAEAEGLRVYTSND--YTYINNYLRGFSDDLGPISTS-TISDIDSALSKMELPADL---TLYRG-TS---SAPFMNIVDK-NY-NGTLDWNSLV---GKTFEDRAFVS-TSVE---SKT--AFGGG-------VRWEINAPKGSKGGMVNTFSMFP-NENELLLPRNSKFLIKGIDKVDNNII--LKMDLI-------
359410883 ----------------------------------GSKIIKSVSDLDKSQIEALIKYTGDD--YVNINNSLRGF-ETLSADNAE-AVDIMKSTLSNASLPEDM---ILYRG-TS-I---EELGSLKN-------LPPDELI---GKTFTQPSFLS-TSTENSVATG--TFSGN-------MQIEIEASQGAHGLDVSSISEYGSDEAEVLFNAGQKMFITDA-----------------------
365970965 --------------------------------------KRLSSLLTDDEVGALYGYTTNEG-YPMVNNALRGQ-TELTPEIQA-FADHATNALDK--LPSYE-G-ITYRG-AT-L-PENVLMENQV-----------------GRVVSDPAFMS---TD---QKV--PFSGD-------TTIKINGKTGKPIDFLSE---YKGTETEVLFKPGTKFEVIERVDSGGKTAL--------------
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    Multiple Sequence Alignment of the ARGA family 
    RES             VIDKTVTLFRPVGQKEMELIRKSGYTSFPPRLPFQPIFYPVLSEEYAVQIARDWNTK-DAASGYIGYVTTFRVRANFLSLYPVQTVG---SSK-HQEY--WIPAEKLAEFNQNIIGLIEVIGKFR
FINAL           ----EEEEEE---HHHHHHHHHH-------------------HHHHHHHHHHH------------EEEEEEEHHHHH-----EEEE---------EEE--E--HHHHHHHHHHH---EEEEEE--
ALIGN           -----EEEE----HHHHHHHHH--------------------HHHHHHHHHHH------------EEEEEEEHHHHHH-----EE---------EEEE--E----HHHHH--HH--EEEEE----
HMM             ----EEEEEE--HHHHHHHHHHH-------------EEEEEE-HHHHHHHHHHHE-E-------EEEEEEHHHHHHHH----EEEE---------EEE--EE-HHHHHHHHHH----EEEEEE--
FREQ            ----EEEEE-----HHHHHHHH---------------------HHHHHHHHHHH-----------EEEEEEEHHHHH-----EEE---------EEEE----HHHHHHH--HHHH--EEEEEE--
PSSM            -----EEEE----HHHHHHHHHH-------------------HHHHHHHH----------------EEEEE----H-------E----------------------HHHHHHH----HHHH----
300869632       VIDKTVTLFRPVGQKEMELIRKSGYTSFPPRLPFQPIFYPVLSEEYAVQIARDWNTK-DAASGYIGYVTTFRVRANFLSLYPVQTVG---SSK-HQEY--WIPAEKLAEFNQNIIGLIEVIGKFR
294817221       VQRATTTLWRPTGPAELELVRELDWRAWPPRLPEQPIFYPVLNEEYAVRIARDWNVR-HDG---AGFVTRFEVDTEFLRRYPVRQAG---GRT-ILEL--WVPADELDTFNAHIVGTIQVVREFH
289770606       TESGTTTLWRPTGPEELALVEASGWTAWPPRLPEQPIFYPVLNEDYAVRIARDWNVP-ASG---SGHVTRFEADTAFLARYPVRRAG---GET-ILEL--WVPAEELAEFNRHIVGRIEVVREFH
21222199        TESGTTTLWRPTGPEELALVEASGWTAWPPRLPEQPIFYPVLNEDYAVRIARDWNVP-ASG---SGHVTRFEADTAFLARYPVRRAG---GET-ILEL--WVPAEELTEFNRHIVGRIEVVREFH
325917965       TAAATVTMHRPLRPEQDALVRVPGFRRWPPRLPEQPGFPPATDRRYAGEIASRWNVK-DSG---VGDVAQFAALAAFVDQYAMQTVG---GAH-HTEW--WIPAEDFDKFNAAIVGSITIIARFD
297204161       TRSSTTTLWRPTGPKELDLVRELDWRAWPPRLPEQPIFYPVLDEDYAIKIARDWNVK-HDG---AGFVTRFEVESDFLSRYPVQQAG---GRT-ILEL--WVPAEELDEFNAHIVGPIEVVHEFR
311900362       TQRSTTTLWRPTGPEELDLVRELDWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HSG---VGFVTRFEVETEFLSRYPVQQVG---GQT-ILEL--WVPAEELDEFNSHIIGRIQVVHEFR
315504426       SSDVTTVLWRPLGQQELDLVREAEGRRWPPLSPEQTHFFPMLDEDFAVRAAQNWNLF-----GPVRYVARFHVETGFLGRYSTRSFG---GSA-APML--WVAADELDEFNAHIVGSIEVIHEFR
304309800       SSATSVTLYRAVGPGQMRAIMERGFARFPARLPQQKFFYPMLTESFASFVATVWNVP-HSG---AGYVLRFRVAPEGIEGKRAFRVG---GPE-HREF--RIGREDFNRFNAAICGPIEVVAVFG
328886920       SQQTTTTLWRPTGPKELDLVRELNYRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVESEFLSRYPVQQAG---GQT-ILEL--WVPAEELDDFNAHIVGEIQVVHEFR
334120906       SDQETVTLFRAVGKKEMELIKESDFLAFPPRLSFQPTFYPVLHKAYAIQIARDWNTR-DAASGYFGYATRFRVAAEFLKNYPVQNVG---SSI-HQEY--WIPAEELAQFNQNIVGKIEIFAEYQ
29826642        SRHGTTTLWRPTGPKELDLVRELKWRAWPARLLGQPFFYPVLNEDYAVKIARDWNVK-HDG---AGFVTRFEVESQFLRRYPVRQAG---GQT-ILEL--WVPAAELDDFNAHMAGEIEVVHEFR
254383863       SRQATTILWRPTGPKELDLVRELNWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVETEFLSRYPVQQAG---GQT-ILEL--WVPAEELDEFNAHIVGEIQVVHEFR
329935140       SQQATTTLWRPTGPRELDLVRDLNWRAWPPRLPGQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVESEFLSRYPVQQAG---GQT-ILEL--WVPAEELDDFNAHIVGEIQVVHEFR
302869104       SSDVTTVLWRPLGQQELDLVREAGGRRWPLLSPEQTHFFPMLDEAFAVRAAQNWNLF-----GPVRYVARFHVETGFLGRYSTRSFG---GSA-APML--WVAADELDEFNAHIVGSIEVIHEFR
239992555       SRQTATPLWRPTGPKELELVRELNWRAWPPRLPEQPIFYPVLNEDYAVRIARDWNVK-HDG---AGFVTRFEVESEFLSRYPVQQAG---GRT-ILEL--WVPAEELDDFNAHIVGEIQVVHEFR
238061986       SDDGTTVLWRPTGPQELDLVRESGWCKWPPRLPDQPIFYPVLNEDYAVMIARDWNVP-ASG---VGYVTRFRVESEFLSRYPVRQAG---GKT-ILEL--WVPAEELDEFNAHIVGLIEVVHEFR
320333489       PVGETVTLYRPVGEQELTLIADTDFRAFPPRLPDQPIFYPVLNFPYAEEIARDWNAR-HNTPP-VGYVTAFEVDARVATGYAIQIVG---REDRHQEL--WVPAEELGAFNAAIRGPIRVLAHHV
160939744       PLGGKMILYRPVGSKELELIKKSNYRRFPPRLVEQPIFYPVLNEQYATEIASSWNVK-YN-EDHRGYVTKFEVDDQYCRQFEVHQVG---GPH-HKEL--WVPAEKLDEFNEHIIGEIHIISEFS
149173583       NGKQTVTLFRPVGQQELDLIQASGWKEFPPRLYWQPIFYPVLTEEYAIMIARDWNTK-DPNSGYVGYVLQFDVEFDYLSRYEPQEAG---GRD-LKEY--WIPSEDLQEFNQHIMGTIDVIHEFR
291301515       NPDGTTTLWRPTGPQELALVEQSGWRAWPPRLADQPIFYPVLNENYAVRIAREWNVP-ASG---SGFVTKFHIDTPYARTLPTQRAG---GNN-EREL--WVPAERLTEFNEHIVGTIEVTHRFS
223935744       MNNETITLFRPVGPKELGLVREGGFKGFPPRLPEQPIFYPVTNEEYAVQIAQRWNVP-DSG---SGYVTRFQVRKEFLSKYDVKNVG---ASK-HNEY--WIPAEDLNEFNRNIVGEIEVIAEFH
298246337       MQEETITLYRPTGPEELALIVESQCTAFPPRLFWQPIFYPVLFEEYAVQIARDWNAR-DGN---SGYVTRFRMRKAFLDRYEVQKVG---SAI-HQEY--WIPAEELDEFNRNIVGPIEVIAEYH
302526847       MDTATTELWRPTGPAELELVRQSGWREWPPRLPEQPIFYPVLNEDYAVKIARDWNVR-YDG---AGYVTRFRVETAFLDRYPVRQAG---GET-ILEL--WVPAEELAEFNAHLVGEIEVVHEFR
296446434       LGDDVMILWRPVGPRELELISASGMREFPPRLPEQPIFYPVTTEAYAIKIARDWNAP--RG---GGFVTRFQVRRSFISRYPIHIAG---GRE-NMEY--WIPAEDLVEFNGAIVGQIEIVAEFP
332671633       IETDVVTLWRPTGPDELALVEASGWRRWPPRLPDQPIFYPVLNEDYAVRIARDWNVK-ASG---AGYVTKFDVRRGHLEEYDVQQVG---GET-ILEY--WIPAERLEELNDNIVGTIEVVRTFR
186681810       GDRETITLFRPTGPKELALIKESGDSEFPPRLPEQPIFYPVLNEEYAAQIARNWNAA-STDTGYIGYVTRFQVRAEFLSRYSVKTVG---GSI-HQEY--WIPAEDLPEFNRNIVGLIEVIAEFR
218679791       EDIETVTLWRPVGPEELALMRDLDMRGFPPRLPDQPIFYPVLSEDYAVKIARDWNVP-RSG---SGFVTRFEVRKDYLNTYAVQEAG---GRA-HLEY--WIPAEEMDRFNAAIVGTIEVMQTFP
330469448       DDVNTTVLWRPTGPRERELVRASGWRAWPPRLPDQPIFYPVLNEDYAIKIARDWNVP-ASG---AGYVTRFHVETDFLSRYPVRQVG---GDT-ILEL--WVPAEELDEFNSHIVGQIEVVHEFG
302553253       DRRTTTTLWRPTGPKELDLVRELDWRAWPPRLPEQPIFYPVLNEDYAVRIARDWNVK-HDG---AGFVTRFEVDSDFLRRYPVQQAG---GET-ILEL--WVPAEELDEFNAHIVGRIELVHEFH
297192271       ATTPTTTLWRPTGPEELELVRKSGWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGFVTRFEVESEFVARYPVQQAG---GRT-ILEL--WVPAEELDEFNAHIVGEIQVVHEFR
171913882       APKPTVTLYRPVGPAELELISASAWKRFPPRLPDQPIFYPVLNEVYAAQIARDWNVA-ASG---SGHVLKFEIDAVYISRFDRQVVG---GSQ-HEEL--WVPAEELEEFNDHIVGTIEVVANYG
302866493       -MTETTTLWRPTGPRELDLVRASGWRAWPPRLPDQPIFYPVLNEQYAVMIARDWNVP-ASG---AGYVTRFHVERAFAARYPVRQVG---GRD-ILEL--WVPAEELDEFNRHLVGPIEVVHEFR
318058555       --MRTTTLWRPTGPAELALVRASGMRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVK-HDG---AGYVTRFAVAADFLARYPVRQAG---GET-ILEL--WVPAEELPEFNVHLVGPIEVVREFH
145596643       -MAETMTLWRPTGPEELDLVRASGWKAWPPRLPDQSIFYPVLNEQYAIMIARDWNVP-ASG---VGYVTRFDADRD---SRPVTRSGRQAGAT-SLSCGCWPRIS--TKFNQHIVGQIEVVHEFR
159038599       -MAETTILWRPTGPEELELVRASGWKAWPPRLPDQPIFYPVLNEQYAIMIARDWNVS-ASG---VGYVTRFEVDREFASRYPIRQAG---GRD-ILEL--WVPAEELDEFNRYLVGLIEVVHEFR
182412866       -MTKTTTLYRPVGPKELALIEASGFRSFPPRLPDQPIFYPVTNEDYAIQIARDWNVP-ASG---SGFVTRFQVESDFLKQYPPRVVG---SKV-HEEL--WIPAEALDEFNRHIIGLIEVTHRFG
297561422       -MPATLTLWRPTGPAELALVGDSGWREWPPRLPEQPIFYPVLNEDYAVRIAREWNLP-RDG---EGHVTRFRVDADFASRYPVRQAG---GRT-ILEL--WVPAGELAAFNAHLVGPIELVRSFL
145595385       -MAETTILWRPTGPEELELVRASGWKAWPPRLPDQPIFYPVLNEQYAIMIARDWNVP-ASG---VGYVTRFEVDRAFASRYPVRQAG---GRD-ILEL--WVPAEELDEFNRHIVGLIEVVHEFR
239626468       -----MILYRPVGTKELELIKKSNYRSFPPRLPEQPIFYPVLNEQYATEIASGWNVK-YN-DDHKGYVTKFEVDDSYCGQFEVHQVG---GAH-HKEL--WVPAEKLEEFNEHIVGEIQIISEFS
163754443       ----MKTLYRPIGEKELILIAESNFTKFPPRLEWQPIFYPVLNEEYAVEIASKWNTK-DEFGNYLGFVTEFEITEEEFNKYKTENVG---SAH-HNEF--WVPAEKLEEFNNAIIGRIKVIKVFI
124007251       -----MKLYRPVGLKELELILAANAKAYPPRLQWQPIFYPVLNFEYARQIATRWNLD-DELSGYAGFVTAFDINDAYIAQFEVQNVG---AHL-HNEL--WIPAESLAEFNTHIHGYIQVLAAYY
284038124       ---MTTTLFRPVSKKELDLIEQSNWTKFPPRLHEQPIFYPVTNIEYARQITIEWNVP-AYG---NGYVTQFEVDSEYLKKYNVENVG---GSI-HNEL--WVPAEELDEFNSQIVGPIKVVESYE
159901068       -----MILYRPVGLEELTLIAQAGYRSFPAQLAEPPIAYPILNLEYASHVAESVKTK-DAEAGYAGFVAEFEISEQYARQFAVKSVG-I-RRR-HREL--LVPIEEFHNFNTRILGHIKVIASFY
256420608       --MNTTILYRPTGIKELALIAATDFKHFPPRLSWQPIFYPVLNQPYAEQIALEWNTN-DEASGYCGIVTRFAVDAAFLERYDIQNVG---DGS-HNEL--WVPAEELEMFNQHITGKIEVVKTFL
83649603        --MKTVTLFRPTGPNELALVEESGFKRWPPRLSEQPIFYPVCNEDYARQIARDWNVK-DSG---VGYVTRFAVDADYLSRFDVKVVG---GRE-HAEY--WIPAEQLEEFNDHIIGGIEVIATYR
296130683       --MSTRTLWRPTGPEELALVEASGRRAWPPRLPDQPIFYPVLNEDYATRIARDWNVK-ASG---VGYVTRFEVATEFLDRYDVQQAG---GET-ILEY--WIPAEDLDELNAHIVGTIEVVAEYR
225390142       -----MILYRPVGKRELELIEQSGYRAFPPRLPEQPIFYPVLNQRYAQEIAGRWNTR-DARSGYRGYVTRFEVEDRYISRFESHVVG---ASW-HEEF--WIPAGELEEFNRHILGRIEVVKTFG
256376037       --MDDVVLWRPTGQAELDLVAGSGWREWPPRLPEQPIFYPVVNREYATRIAREWNASGAEG---VGYVTRFAVEGEFLAKYPVQSAG---GSG-IDEH--WVPAEELEEFNRHVVGRIEVEAEYR
333985238       -----MILYRPVGHNELALIVESGLKGFPPRLPDQPIFYPVLNAGYAKQIALEWNTK--S-DTFSGYVTRFNIDNDYAQKFNREIVG---GKV-HEEL--WVPSEELSEFNQKIVGHIEIISAYF
338532263       -MSNPLTLYRPVGLKEAELILDSGCSAFPPRLPDQPIFYPVMNAEYARQIARDWNTP-DAGSGYAGFVTAFGVDADYASRFPVRTVG---NSL-HQEL--WVPAEDLATFNQHIQGPVRFTEAWY
303241812       -----MKLYRPVGISELELIKQSGMTKFPPRLPDQPIFYPVLNRKYACQIAREWNTK-SA-PGYAGFVTEFDVDDDYISKFEVKTVG---AFV-HTEL--WIPAEELDEFNRHIIGEIKVIESYY
269118724       -----MKLYRPVGLQELEKILNFGSEKFPDRQVWQPILYIVENYGYAEQISTMWNLK-DENSGFSGYILEFTISDDYMKNYDIKQVG---DKT-HLEY--WIPAEDTKKFNNSLTSKIKIINAFY
108763108       -MPNTRALYRSVGLKEAELFLVSGCSAFLAPTARPAHLLPGDERRVRTANCRDWNTP-DAGSGHAGFVTAFDVGADYASRFPVRTVG---NSR-HQEL--WVPAEELATFNQHIQGPVRFTEAWY
16126106        --MTSVTLYQPVGLEELQAIKASDWRAFPPHDIEQPVFRPVTSEAFAAQLARDWNAA-HTTYR-RGYVVQFAVSKTFLDAYENKVSG---TPG-HEEY--WIPSEDLSLLNAAIQGQIAVAGTFA
162453007       -----MILYRPVGLAELRLIAEAGYRAFPPRLSHQPIFYPVLTEEYARKIARDWNTA-DETSGFAGWVTRFEVEDDFARRYPVQIAG---GRS-HEEL--WVPAEELEEFNRHLVGTIEITEVYC
126740444       -----MKLFRPTGLKELVLVRDSGWASWPPRLPDQPIFYPVTTFGYAEKIARDWNSV-LPAPDNMGFVTEFTISEAAARRYPVEEAG---GRE-HREL--WVPAEELEWFNGELTSTIRIVSAYR
300774507       --MKTTTLYRPVGEKEMILIMESGFKSFPPRLEWQPIFYPVLNEEYASEIAEKWNTR-DEAGNYLGFVTQFEVLEEVADQYPTQNVG---ARN-HNEL--WVPSEELNSFNKAIIGDIKYR----
consensus/100%  .......habs....b...h.......a.........h.......h....s..hp............h..F.h.......b.....G.............b........hN..h.u.l.h.....
consensus/95%   .......LaRs.G..Eh.hl.......aPsb...Qs.hhPh.pb.aA.bhu..WN..........GaV..F.h....h..h..p.sG...s.....bh..Wls..ph..hN..l.G.Iph...a.
consensus/90%   .......LaRPsG..Eh.Ll...shp.aPsRL..QPhFYPl.sb.YA.blAppWNs.........GaVspF.l...hh.pa..p.sG...s.....Eh..WlPu-ch.pFN..l.G.Ipl...a.
consensus/85%   .......LaRPsG.pEL.Ll...shp.aPPRLs.QPIFYPV.sb.YA.bIApcWNs.........GaVspFplp..ah.pa.sp.sG...u.....Eh..WlPAEcL.pFN..lhG.Iplh..a.
consensus/80%   ....s..LaRPsG.pEL.Llb..shp.aPPRLspQPIFYPVlscpYA.bIApcWNs...ss...sGaVTcFplp..ahppassppsG...up....Eh..WlPAE-L.cFN.pIlG.Icll.pa.
consensus/75%   ....s..LaRPsG.pEL.Llb.ssac.aPPRLs-QPIFYPVLscpYA.bIAc-WNs...ss...sGaVTcFcVc..ahppYslppsG...up...bEh..WlPAE-LscFN.pIlG.IcVl.pa.
consensus/70%   ....o.sLaRPsG.pEL.Llb.usa+.aPPRLP-QPIFYPVLNEpYA.bIAR-WNs...su...sGaVT+FcVcspahs+YslppsG...Gpp..bEh..WlPAE-Ls-FN.cIlG.IcVlppF.

#==== Truncated members
126740444       -----MKLFRPTGLKELVLVRDSGWASWPPRLPDQPIFYPVTTFGYAEKIARDWNSV-LPAPDNMGFVTEFTISEAAARRYPVEEAG---GRE-HREL--WVPAEELEWFNGELTSTIRIVSAYR
119477262       -----------MSPAQLAAVVASDWRQFLQEAPQQTIFYPKMYVGYAEQIAKQWNAR-QYS---AGYVVGFTMPGTFMDRYETQTIA---YEE-HRDY--KLPVAELDVFNSHIQGRIRVAAAFA
148256740       ------------------MIAASGMRAFPPRLPEQPIFYPVLTEAYAVKIARDWNVP-ASG---SGHVLRFEVLRTFVDRYEVREAG---GRD-HLEY--WIPSEHLAEFNAAIVGPIVLVKTFP
146341856       ------------------MIQATGMRAFPPRLPEQPIFYPVLTEDYAVKIARDWNVP-ASG---SGHVLRFQVRREFIDRYEVREAG---GRD-HREY--WIPSEDLAEFNAAIVGTIALVKSFP
330467180       -------------------MEASGWREWPPRLPDQPIFYPVLNRWYATKIAREWNVP-AGG---VGYVTRFEVQREYMDRYEVHQVG---GRD-VLEY--WIPAEELADFNAHLVGAITEEADYR
290960596       --------------MELDLVRESGWRAWPPRLPEQPIFYPVLDEAYAVQIARDWNVK-HDG---AGFVTRFEVDAGFLRRYPVRQAG---GRT-ILEL--WVPAEELEEFNAHIVGAIEVVHEFR
94971452        ----------------------------------------MLTIEYARQIARDWNTR-HERSGYAGYVLRFAVDTDFLSRYEIQRAG---SDA-HLEY--WIPAEEMEEFSVHIVGDIEVLEQYT
239626503       -----------------------------------------MNKQYAIEIASGWNVK-YN-EDHRGYVTKFEVDDQYCRQFEVHQVG---GAQ-HKEL--WVPAEKLDEFNEHIIGEIHIIKEFP
312888451       -----------------------------------------MNEEYAIQIARDWNVP-AWG---SGFVTRFAVSSSYLKKFEVQNVG---GVI-HNEL--WVPAEELEEFNDHIIGLIEVTKTFL
282864000       -------------------------------------------------------MK-HNG---VGYVTRFEVGSDFLVRHPLQQDD---GRT-IPEL--RVPAEEPDDLDAQSAGDIRVVHKSR
13470985        ------------------------------------------------------------------------MLKSFLDRYRVEHAG---SKA-HLEY--WIPAEDLDDFNKAIVGKIEVTATFG
158333527       -----------------------------------------------------------------------------MDNYDIQKVG---GAH-HTEW--WIPAEKLEELNDNIVGEIEVIGEYR
289663132       -------------------------------MPEQPIFYPVTNQRYAEEIASRWNVK-DSG---LGYVAQFEVSAAFVEHDAIQNVG---GAH-HTEW--WIPAEELDALNDTIAGLNDIIGQFD
13470984        EAQPTITLWRPIGPEELKLIEASNMRAFPPRLPEQPIFYPVLSEAYAVQIARDWNVP-ASG---AGFVTGLPC----------------------------------------------------
329184512       AMKDVVCLYRPVGEAELQLIAAAVFKAFPPRLPEQPIFYPVLNFEYAAQIARNWNTK-DKNSGRAPRRSV-------------------------------------------------------
310818708       --METVTLWRPVGPEELALIREADMRAFPPRLPEQPIFYPVTTRDYAVKIARDWNVP-ASG---SGFVTQFEVRKDFLDHYEVQEAG---GQA-HRE----------------------------
153873366       ME--TITLFRPIGQTEMDLIVQSDYLAFPPRLPFQPIFYPVLQEDYAVQIHEIGILMMRLRAMLAM-----------------------------------------------------------
315502903       TE--TTTLWRPTGPRELDLVRASGWRAWPPRLPDQPV----------------------------------------------------------------------------------------
    Back to Contents
    Multiple Sequence Alignment of the NUE family 
    ALIGN           --------------HHHHHE-E-----EEEEEE----HHHHHHHHH----------------EE----HHHHHHH----------HHHHHHHHHHH--HHHHHHHHH-------------------------------------------------------------HHHHHHH------EEEE-------------H----HHHHH-----HHHH-HHH--EE--EEEE---HHHHHH-HH-HHH--------------------------------------HH-HHH-------------
HMM             ---------------EEEEE-EE----EEEEEEE---HHHHHHHHH------------E--EEEE--HHHHHHHHH---------HEEEEHHHHHHHHHHHHHHH--------------------------------------------------------------HHHHHHHH------EEEEE---H-------------EEEEEE---HHHHH-HHHHHHH--EHHHHHHHHHHHH-HH-HHH-------------------------EE----E----HHHH-HHH-------------
FREQ            --------------HHHHHH-H-----EEEEEEH--HHHHHHHHHH----------------EE--HHHHHHHHH----------HHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------HHHHHHHH------EEE------------HHH----HHHHHH---HHHHH-HHH--EE--EEEE---HHHHHH-HH-HHH---HH------------------HH------------HHH-HHHHH-----------
PSSM            ---------------EEEEE-EE-----EEEEE----H-HHHHHHH---------------EEEEE--HHHHHHH-----------EEEEEEEE-HHHHHHHHHH---------------------------------------------------------------HHHHHHH------EEEEE-----------------EEEEE----HHHHH-HH----E--EEE----HHHHHH-HH-HH--------------------------------------HHH-HH--------------
FINAL           ---------------EEEEE-EE----EEEEEEE--HHHHHHHHHH---------------EEEE--HHHHHHHH-----------EEEEHHHHHHHHHHHHHHH--------------------------------------------------------------HHHHHHHH------EEEEE------------E----EEEEEE---HHHHH-HHH---E--EEEE---HHHHHH-HH-HHH------------------------------------HHHH-HHHH------------
294781860       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNDKIADEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVKNSVISSYKPNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIHGKLIGR----RSIQLGIR-GEAVE-KYVNEWI--VKITDITDDVKRI-KK-VLIMELLK----------------------------------------------------
256422007       ------------MKEKTIRA-LYDE-ESITVYQAYNGLIAKRAVEAQTF-TTPPFRRDR--MTWIKPSFCWMMYRSGW-ATK-EDQEYILAIKIKRSGFEWALQNAVLSKFDHKIHS-------------------------------------------------TTNEWNRLLKAS--PVRVQWDPERDIYLQPTDQ----RALQIGIS-GTAVD-QYISEWI--IGIEDITAYSQHI-GQ-LVKVRKIE----------------EAMALLPQERPY-PLPV-------------------
300789763       MFE------EQRVPDRQVRA-AQTE-TTVRVYQACSPAVADAALEEQTF--------ERGGTVQLTPSFRLAAYGSEN-GRK-PGHERILAIDLTRDGFEQALTHS----------------------------------------------------------------------------HVEWEAERDLDHTALNF----QAIRIGLD-S-----APADEWI--TAITDVTPVVRDI-AG-LLATDQLH----------------LAVKLVPHEPPY-ELG--------------------
228473982       MK-------DITQEERKIYA-LYDN-NTIRVYQAYNAEIAEEALKLGTF-GSH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVRKSVLSSYKADLGI-------------------------------------------------TEEQWKEDVKNS--LVRCQWDPERDIYGKPIGR----RSIQLGIR-GAFVE-KYVNDWI--VKITDITEEVKRI-KQ-HIDKGTFT------------------KDLLPKEQEY-IIP--------------------
257125945       ---------MKKGEERNIYA-VFDD-KTIRVYQAYNNEIADEALKLGKF-GSK-FSLTR--MTWIKPSFLWMMYRSGW-ASK-QGQERILAIDLKREGFDEIVKNSVLSSFREVSDL-------------------------------------------------SKEEWKNKLDNS--EVRCQWDPDRDIYGNPLGR----RAIQLGIK-GETVK-KYVNDWI--VNITDITDKVVEI-RN-SIQNGTFS------------------ESMLPKEIKY-I----------------------
254302431       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNNVIAGEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVKNSVISSYKTNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIYGKPIGR----RSIQLGIR-GEAVV-KYINEWI--VKITDITDEVKRI-KQ-SIDNGTFK------------------ESFLPEEKEY-IVK--------------------
336250841       MEKHLP---KYSIPERQIRA-FFTK-DFIRVYQAYSDEIADSAIKNNTF-VSPPFSLTR--MTWIKPSFLWMMYRSGW-GKKDSNQTRILAIDLSHDAFQKILHLGVPSDYHSASTF------------------------------------------------QNKEEWQDKIKNS--DIIFQWDPERDIHLNKLNY----RTIQIGIR-NQAVI-NFCNEWI--VNLHDITHQVQEI-HN-LVSLGDFC----------------KAKTLIPTEKTY-HFQL-------------------
260889576       ---------MKKEEERNIYA-VFDD-KTIRVYQAYNNEIADEALKLGKF-GSK-FSLNR--MTWIKPSFLWMMYRSGW-ATK-QGQERILAIDLKREGFDEIVKNAVLSSFREVSDL-------------------------------------------------SKEEWKNKLENS--EVRCQWDPDRDIYGNPIGR----RAIQLGIK-GETVK-KYVNEWI--VNITDITDKVIEM-RE-KIENGSFL------------------DSNLPIEEKY--V---------------------
256374811       ------------MESRQIRA-DFDE-RTLVVYQAYSPEIAEPALAAGTF-VPP-FKPGR--MTWVKPSFLWMAYRCGW-ARK-AGQERVLAVRVLREPFDAAVLAAVPSREVVEGKP---------------------------------------------------------------EIRVQWDPERGLRHEALGH----RSLQLGLA-GGASR-RYVEEWI--TGLTDVTGLMTRV-GA-AVAAGELE----------------LARELLPVERAY-PLEV-------------------
226327538       MNDD-----RVDCPECEVRA-YYTN-DFVRVYQAYSNTIAQSAVANGTF-VSPPFSMTR--MTWVKPSFLWMMYRSGW-GRKDANQASILAVDITHEGFQEMLTQGVVSHFDPDRYV-------------------------------------------------SAEAWKAASETS--NIRIQWDPERDIYLNRLSY----RTIQIGLR-NQAVE-KYCQEWI--VNITDITDKARKI-DN-CIANGDLD----------------TAYSLLPVEKPY-HFGE-------------------
197286762       MNDD-----RVDCPECQVRA-YYTD-DFVRVYQAYSTTIAQSAVANGTF-VSPPFSMTR--MTWVKPSFLWMMYRSGW-GRKDPNQASILAVDITHEGFQQMLTQGVVSHFDPDHYV-------------------------------------------------SAKEWQEATETS--DIRIQWDPERDIYLNRLSY----RTIQIGLR-NQAVE-KYCNEWI--VNITDITDKVRKI-DT-CITNGDLD----------------TAYSLLPIEQPY-HFAK-------------------
262067268       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNDKIADEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKREAFDEIVKNSVISSYKPNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIHGKPIGR----RSIQLGIR-GEAVG-KYVNEWI--VKITDITDDVKRI-KK-SIDNGTFK------------------ENLLPEEKEY-IIK--------------------
340754465       M--------KYEEQERKIYA-KYDD-KTIRVYQAYNNVIADEAIKLGTF-GEH-FSLTR--MTWIKPSFLWMMYRCGW-AEK-ENQERVLAIDIKRAAFDEIVKNSVISSYKPNLGI-------------------------------------------------TEDEWKEEVKNS--LVRCQWDPERDIYGKPIGR----RSIQLGIR-GEAVE-KYVNEWI--VKITDITDEVKRI-KK-SIDNGTFK------------------ENLLPEEKEY-IIK--------------------
167588668       MKSHLKQT-PEAIPLRQIRA-MYDD-RTIRVYQAYSDAIADSALTHGTF-VSPPFKTER--MTWIKLSFLWMMYRSGW-GLKDSGQARILAIDISREGFEWALAHSCLSHPDESMHR---------------------------------------------------DEWQRMKEKA--PVRIQWDPERDLLLQPLAY----RAIQVGLS-KQAVD-LYVHEWI--QRITDVTPLAHSL-HA-LVGQGDFE----------------SAQALLPLEQPY-CIGA-------------------
191169136       -----------MADYFEIRA-DYNQ-HTITIYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQHILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGIWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSEAA-RKALG--MK-------
345368115       -----------MADYFEIRA-DYNQ-HTITVYQAYNDAIADVAVRNGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQRILAIRIKRTFFDTLLEQSVLTTPEAHVYP-------------------------------------------------HAGIWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSAAA-RKALG--MK-------
193070962       -----------MADYFEIRA-DYNQ-HTITIYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQHILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGIWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSAAA-RKALG--MK-------
312199543       VDRRP----ADGAGMREVLA-SHTA-ATLTVYQAYSPAIAGPALRAGTF-VEP-FRVGR--MTWVKPSFLWMMYRCGW-ATK-PDQERVLAVEIGRDDLLWALARACLSSFEPGQHA-------------------------------------------------DPRSWRAALAAA--PVRVQWDPDRDLYLRPTGR----RAIQIGLG-PEASR-HYVSSWI--RSIRDVTPLAREI-HA-RVQADDLD----------------GARALLPEEHPLALPSEIA-RRLGA--SP-------
218547498       -----------MADYFEIRA-DYNQ-HTITVYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQRILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGVWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSAAA-RKALG--MK-------
170684105       -----------MADYFEIRA-DYNQ-HTITVYQAYNDAIADVAVRDGRF-GAP-FSFNR--MTWIKPSFMWMMERSNW-GLK-KDQQRILAIRIKRTFFDTLLEQAVLTTPEAHVYP-------------------------------------------------HAGVWETLFAQA--NVYVQWDPERSINGKKLEH----RSLQLGIS-RNLIS-QFNEDAI--VAIDDLTPLVRKC-HN-LLINGKTT----------------QAKSFLPPEKIY-PVSATA-RKAWG--MK-------
311896751       ---------MTETPKRQVRA-RYDE-ETVTVYQAFRPEIAEPAVAGGRF-PAA-FDPGR--MTWVKPSFRWLMHRSDW-ARS-EGQQRVLGVVLWRAGFDAALEAAVLSSYERGVHA-------------------------------------------------SRAEWQRELRRS--EGRAQWDPERDLELRPLAH----RSLQLGLS-GSLVE-RYLGEWL--VRIDDLTPLARAL-HA-TRDP-----------------------GLLPPERPY-PLPAGA-AVRLG--AS-------
255930929       ---------MTSTTYRAIRA-KQTP-TTVTVYQAYPPEIADPALEAHTF-VPP-FSRDR--MTWIKPSFLWMAYRSGW-ATK-PRQERVLAIEISREGFEWALRNCCLSHYSPSEET-------------------------------------------------SQEKWRKRLRAS--PVRVQWDPERDLSLRSLDY----RSIQIGLS-GEAVR-RYIDEWI--VSIADVTHTMKQI-DG-YLKDGDVD----------------AARSDLPEERPY-ILPEDL-QENLR--MK-------
163754444       ITQNN----EWPQNGHHIMA-QYDD-EKIIVYQSYRPAIGLFAAENQFF-GGP-FSLER--MTWIKPNFLWMMYRNGW-GTK-VGQEVVLAIHLKREAFQKYLENAVHSSFKPELYE-------------------------------------------------SQEMWKEAVKSS--NVRLQWDPDHDPYGAKLER----RAIQIGIR-NEFIR-SYAKEDI--LEIENISEFVAEQ-YE-FVKSNQLE------------------KLMIPAERPFLPEGDEL-RKKLQ--LQ-------
239987775       MNT------PPVPPRHEIRA-LHTA-TTVTVYQAYRPAIGLPAARDGRF-PAE-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQEVVLAVEIDRSGLEWALANAELSHYVRDVHP-------------------------------------------------DQATWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEASR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVQVDDLAA-------
291444753       MNT------PPVPPRHEIRA-LHTA-TTVTVYQAYRPAIGLPAARDGRF-PAE-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQEVVLAVEIDRSGLEWALANAELSHYVRDVHP-------------------------------------------------DQATWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEASR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVQVDDLAA-------
124002565       ---------MKQKNKYEIRA-LYTP-KHIALYAAFSSSIANVALKSQQL-LPP-FSYDR--MTWVKPSYLWMMYRSDW-AQK-DNMQRILRIWIKRIDWELALKEAILTTPEAHVYN-------------------------------------------------DAKKWRKQLDKA--RVRVQWDPERDIQNKHLSF----KSIQVGIM-PSLAE-TYAKKWI--AKIEDVTPLTQHI-RS-LVVAQQFE----------------QATQLLPKEQAY-PVEAEL-KRILG--IG-------
110639136       ------------MLEKQIRA-VYDQ-QTITVYQAYKNEIAIPAVKNQKF-VAP-FKIER--MTWIKPSFLWMMYRSGW-AAK-EGQEHVLAIKLKREGFEWALANCCLSHFDSTMFS-------------------------------------------------SLEAWKNKLEHT--QVRLQWDPEKDIHLQNLAY----RSIQIGLS-GVAVE-HYVNDWI--VSIDDITPVCKKI-HA-LVLDKKTE----------------EANSLLPAENIY-PVSETL-KHTIG--AD-------
344999740       MNV------QATPPRYEIRA-QHTA-ATVTVYQAYRPAIGLPAARDGRF-PAA-WKRDR--MTWVKPSFLWMMYRCGW-GAK-EGQEVVLAVEVERAGLAWALANAELSHYVRGVHP-------------------------------------------------DEAAWKQALRSA--PARVQWDPERDLNLNPLPY----RSLQLGLS-GEAAR-RYADEWT--VSIRDVTPLARDV-HA-LVRAGDRD----------------RAASLLPTETPL-HLPAPR-PL--------------
326779281       MNT------QALPPRYEIRA-RQSA-TTVTVYQAYRPAIGLPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EEQEVVLAVEIDRGGLEWALAHAELSHYAAEVHP-------------------------------------------------DQAFWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEAAR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVRA---AS-------
124004042       KDYET----DLPQEGRHILG-QMTNAENLIVYQAFNPSIAKYAVTHQQF-GGSQYSFSR--MSWIKPNFLWMMYRAGW-ASK-PNQERILAIEISKQNFELILEEAIHSSYVAEVYG-------------------------------------------------SRADWQAKLKAS--NVVMQWDPDHAPNGDKLQR----RAVQLGLR-NELLK-NFGTHWA--VSIQDITDFVLEQ-GK-CLRGQKMD------------------ELLVMQEQVI-AIDNPE-VVKRLG-LA-------
336471510       FSNL-----PPKPPSRQIRALQEDDGTTITVYQAYPSTIATAAVIHQRLDASPEFRTTR--MTWIKPSWAWMLYRSGY-SYKDPGQERILAIKMKREDFLGLLGRGVLTHGTAPPRP----------------GPQQGQGITSDAQGRTSGER---GEEAAPKESTRESKRKDRLQSL--DVKIQWDPERTVRLHSLNY----RSIQIGIP-AGLIR-EWAQDMI--VNIEDVTDKARTL-KK-ILDERPDV-----------NDEELAELGLIPKETEF-EVPVEL-RSRLG-----------
169773039       MATNN----ANLQPFRAIRA-QSTQ-STITVYQAFSPEIAEPALRAQKF-VPP-FSRTR--MTWIKPSFLWMAYRCGW-ATK-PKQERVLAIEITREGFEWALRRSCLSHVPGSRDQ-------------------------------------------------DQEKWRQRLRES--PVRVQWDPERDLWHRPLGY----RSIQIGLS-GEAVE-RYVDEWI--VSITDVTGLMGDV-KR-ALDKADAE----------------GAEGLLPVESVY-PLSEEL-RDILD--AT-------
85068247        FSNL-----PPKPPSRQIRALQEEDGATITVYQAYPSTIATAAVTYQRLDASPEFRTTR--MTWIKPSWAWMLYRSGY-SYKDPGQERILAIKMKREDFLGLLGRGVLTHGTAPPRP----------------GPQQGQEMTSDAQGRTSGER---GEEAAPKESTRESKRRDRLQSL--DVKIQWDPERTVRLHSLNY----RSIQIGIP-AGLIK-EWAQDMI--VSIEDVTDKARAL-KK-ILDERPDV-----------IDEELAELGLIPKETEF-EVPVEL-RSRLG-----------
182438632       MNT------QALPPRYEIRA-RQSA-TTVTVYQAYRPAIGLPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQEVVLAVEIDRGGLEWALAHAELSHYAAEVHP-------------------------------------------------DQASWKRSLRTA--PARVQWDPERDLDLNPLPY----RSLQLGLS-GEAAR-RYADEWT--VSVRDVTPLAREV-HA-AVRAGERE----------------RAAALLPVETPL-DLAAPR-PVRA---AS-------
254387007       PDPA-----PVPVPNRAVRA-AHTA-RTVTVYQAYAPHLGLPAARDGRF-PHA-WKRER--MTWVKPSFLWMMYRCGW-ATK-ADQETVLAVEITREGFDHALRRACLSHYEPGTHA-------------------------------------------------DRASWQRALRGA--PARVQWDPERDLHLNPLPY----RSLQLGLS-GPASR-AYADEWT--LSIRDVTPLAREI-HG-LLRAGNAD----------------AARALLPGETPY-P-SPPL-PHLGA-----------
70988759        ---------MARHPYRQIRA-KYTS-TTITVYQAYSPSIADAAVDAQKF-VPP-FSRTR--MTWIKPSFLWMAYRSGW-ARK-PKQERVLAIDITREGFEWALQHSCLSHYPGHDVE-------------------------------------------------EKAKWQKRLQNS--PVRVQWDPERDLQFTPLDY----RSIQIGLS-ADAVD-KYVDDWI--VGITDVTEVMRQI-EK-CLAEDRME----------------DATRLVPAEEVY-PLSEEL-KGILE--AT-------
302535927       P--------APETPRHQIRA-AHTA-TTVTVYQAYAPHLGVPAARDGRF-PPA-WKRER--MTWIKPSFLWMMYRCGW-AAK-ADQETVLAVEISREGFDRALAQACLSHYVPGVHA-------------------------------------------------DREAWKASLAGS--PARVQWDPERDLHLNPLPH----RSLQLGLS-GPASR-AYADEWT--VSIRDVTPLAREI-HG-LVRAGDLD----------------AARALLPAETPY-PAGPLP--HLGA-----------
66813652        M--------SNKNYKRIIKA-VYND-ETIRVYQAYNKEIAEGAVKNQRF-VDP-WLTTR--TTWIKPSLCWMMYRAGY-GYKDKNQERILAIDIKREAFEWILDTYYDNNNENLNDL------------------------------------------------------KAYAKN---SLVIQWDPERSIKIGKLEN-GELRSIQIGIK-PNLTQ-KFNNEWI--AEINDITDIVHQI-KR-EIDDGNIE----------------KAISLLPIEKVYTPINVKF-----------------
66802638        M--------TDNNYKKIIRA-VFTD-DTVRVYQAFNSKIADDAILNQKFTLESGWSDNR--TTWIKPSFCWILYRSGY-ACK-HNQERILAIDIKREAFEYILENHIDAHETGKSAI------------------------------------------------------PSSKK----KIVVQWDPERNISISKLDGCGDIRSIQIGVK-KAKIK-EYNEQWI--QAITDVTPIAHQI-KK-ELDKGDLE----------------KAKSLLPDELVYTPKNVRF-----------------
124007793       -----------MNNTQEIRA-QYDA-DTITVYQAYGKAIALPATKVNQF-APP-FSFQR--MTWIKPSYLWLMERSNW-ATK-PQQEFILGIKIKRAYWEYALSLGVLTHPDLAIYT-------------------------------------------------DGLDWEQKFSQA--KVHIQWDPERTLRGAKLQV----RSIQVGIS-RHLIE-QYNNEWI--VAIDDLTPLTRKI-SQ-LKKQGKYK----------------EAKQLLPKEQVY-VLPDEL-QKRIG--VR-------
119497805       ---------MARHPSRQIRA-KYTS-TTITIYQAYSPSIADAAVDAQKF-VPP-FSRTR--MTWIKPSFLWMAYRSGW-ARK-PNQERVLAIEITRKGFEWALQHSCLSHCPGQDAE-------------------------------------------------EKAKWQKRLQNS--PVRVQWDPERDFQFRPLDY----RSIQIGLS-ADAAD-KYVDEWI--VGIADVTEAMRQI-EK-CLAEGRTE----------------DAARLMPAEEVY-PLSEEL-KDILE--AT-------
121719366       ----------MNPPYRQIRA-KYTP-TTITVYQAYNDTIATNALAAQTF-VAP-FSRTR--MTWIKPSFLWMAYRCGW-GKK-PRQERVLAIEITRDGFEWALRHSSLSHYGGRDPE-------------------------------------------------GKAAWQERLRAR--PVRVQWDPERDLEFKGLAY----RSIQVGLG-GEAVE-RYVDEWI--VGITEVTETMREI-EQ-CMEEGRME----------------EARALVPLEEEY-PLSEEL-REILE--AR-------
303240837       --------------MNRIFA-YFDD-EGVYVYQAFKPNIVKNAVEIGTF-GKG-FGLDR--ITWIKPSFGWILHRSSY-ATK-HRMEAIAKIKLSHKAWLEILSQSVPSQFDSSRYK-------------------------------------------------NETIWKADFEKS--DVIHQM---------KLNR----RAIQIGLR-NEAIK-KYVYEWI--IGVEDVTDLAKEI-SS-IIKSGKDP------------------SSLLPDISEY-PISDDL-KNIIG--YT-------
322708785       M--------ASTPPYRQIRA-TYTP-DTITVYQAYKRSIADAAVKHQKLNASPDFRPGR--MTWVKPSWSWMMYRAGY-SYKDPGQERILALRMKHEHFIALLDKGVLSAHTERIGG------------------------------------------------VGGGEQGPRDKTS--EVRIQWDPERDERLRVLPY----RSIQIGIP-GSLSK-KWAEEWI--AEIEDVTEKARGL-KA-ALDERADV-----------TREELLDMGYVPEERVF-EVGHDI-RERLG-----------
256376409       -----------MAPQRQIRA-DYDD-SHITVYQAYSSAIADPALAAGRF-VPP-FSFGR--MTWVKPSYLWLMHRSNW-ARK-PGQERVLAVRITRAGWERALAQAVLTGSPGLEGA---------------------------------------------------------------RVHVQWDPERSLRGAALNH----YSIQVGVG-RDVVR-ELVDEWT--TGVADLTGRTRRI-AA-LLQAGRAE----------------QARRLLPPERPY-PLPVAI-ATRLD--AG-------
322699163       M--------ASTPPYRQIRA-TYTP-DTITVYQAYKRSIADAAVEHQKLDASPDFRPGR--MTWVKPSWGWMMYRAGY-SYKDPGQERILALRMKHELFVALLEKGVLSAHTERIGG-------------------------------------------------GGGEQGPRDKPS--EVRIQWDPERDERLRALPY----RSIQIGIP-ASLSQ-KWAEEWI--TEIEDVTEKARGL-KA-VLDERGDV-----------TREELVDMGYVPEERVF-EVSQDI-RERLA-----------
346318305       SQA------TPTVPYRQIRA-LYDD-STITVYQAYSPSIADAAVAAQRLDASPDFRPGR--MTWIKPSWAWIMYRAGY-SYKDARQARILALRMTHAHFLGLLNRGVLSHGGNLAPD-------------------------------------------------------RLDKNA--EVRIQWDPERTPALHRLPY----RSIQIGIP-GSLSA-QWVADWI--ISIEDVTDTAREL-KR-TLDENPDV-----------ELQELVNRGLVPVEKFF-PVPESI-MAKLD-----------
162457230       -----------MPKLHEIRA-DYDA-ETIVMYQAYAPAIAEPALAAQRF-VAP-FSFGR--MTWIKPSFLWLMHRSNW-GRK-AGQERILAVRIRRTGWEHALSLAVLTSPEATVFR-------------------------------------------------SPDEWSKAFAEA--KVHIQWDTERNLRGGPLPC----YSIQVGVG-RDLIR-EYAESWV--VAIEDRTPLVRKM-YQ-QIQAGHAD----------------SAAKSLPRERPY-AVDEKI-ARRLL--ID-------
340521231       MSR------PSDIPHRQIRA-SHDK-DHIVVYQAYKPSIASAAVKAQKLNASEDFSPDR--MTWIKPSWCWMMYRSGY-SYKDPNQSNILAIKMKMEHFLELLRQGVLSNHPSEHAR----------------------------------------------VDKDSTNKTAHERPS--DVRIQWDPERNARLEALPY----RSIQIGIP-PNLGT-KWVDEWI--VGIEDVTERAREL-KR-VLEEEPHI-----------GEDELVKRGLVPEETPV-DVPDDI-MTRLD-----------
302529076       ------------VPRRDVRA-GYTD-QTITVYQAYSRHIADVAVESQTF-AAP-FKRER--MTWIKPSFLWMMYRSGW-ATK-PEQERILEIQLTREGFEWALAHAALSSYEPGAYA-------------------------------------------------GQQHWAERKRTS--PVRIQWDPDRSLTLAPLDR----RAIQIGLS-GEAVE-RYLDQWI--AKITDITPFAERI-HR-HVSSGRLE----------------AAREELPGERVY-PVPAPI-LGMIG--AS-------
262199521       ---------MSQTSTREIRA-DYNA-DSIVVYQAYRDDIADPALREQRF-VEP-FSFHR--MTWIKPSFLWLMHRSNW-GAK-KGQERTLRVRIGRAGWEEALAQGVLTSPDGPVFG-------------------------------------------------NAAKWQRAFAAA--KVHVQWDTERSLRGAALDH----LSIQVGLG-RHIIQ-RFVEEWI--VAIDDMTASVAKM-RR-LLQQGKVA----------------EAKRLLPSERVY-SVPDDI-ARRLW--FD-------
238490968       MATNN----ANLQPFRAIRA-QSTQ-STITVYQAFSPEIAEPALRAQKF-VPP-FSRTR--MTWIKPSFLWMAYRCGW-ATK-PKQERVLAIEITREGFEWALRRSCLSHVPGSRDQ-------------------------------------------------DQEKWRQRLRES--PVRVQWDPERDLWHRPLGY----RSIQIGLS-GEAVE-RYVDEWI--VSITDVTGLMGDV-KR-ALDKADVE----------------GAEGLLPVESVY-PLSEEL-RDILH--AT-------
115387213       MEGSHASTVHHAHGYRVIRA-KYTP-TTITVYQAYSPEIADAAIRAQRF-VSP-FRRQR--MTWIKPSFLWMAYRCGW-ASK-PNQERVLAVEITREGFEWALRHSCLSHAAAT----------------------------------------------------KQEEWQQKLQSR--PVRVQWDPERDLSFRPLGY----RAIQVGLG-RESVD-RYIDDWI--VSITDVTQTMKQV-AQ-YVADGMVE----------------EAKACLPEERVY-PLSDEL-REILD--AT-------
290963088       -----------MAPPYQIRA-DYDA-DTIVVYQAYAPAMADAALRAGRF-VAP-FSFRR--MTWIKPSFPWLMHRSNW-ARK-PGQQRVLAVRMSRHGWEEALSRAVLTTEDPAAVA-----------------------------------------------------------RA--AVHVQWDPERSSRGAALNH----YSIQVGIG-RDLIR-TFTDEWI--VSLTDLTPQVRKA-AT-LTQTGHAA----------------QAQRLFPAERVY-PLPPHL-ERLL---TS-------
168699093       -----------MGAAREIRA-DYDR-DTIAIYQAYPPAIADAALAAGRF-VPP-FSFHR--MTWIKPSFLWLMHRSNW-AQK-RGQERVLCVRVRRSGWEAALAQAVLTSFEPTVFT-------------------------------------------------DPDTWAEQFATA--RVHLQWDPERSLRGAGLPY----DSIQVGLS-RHVIR-EYADDWV--ARIEDYTPVVRKV-YT-LLQSGRAD----------------KARRFLPPERVY-PVGGEL-GRRLS--LR-------
328866607       MSS------EFISKEFQIRA-VYNK-ETIRVYQAYNNEIADYAVKHQTFTGCPHWSTER--TTWIKPSFLWMMYRSGW-AQKDKNQNRILAIDIHIKDFEYAIQNNYKSSTKQKYQI------------------------EGQELPPPSKEHS------------QPPVSKVDKSNY--DIVVQWDPERSIKLGKLGSN--IKSIQIGIK-KRIAE-QYSSNWI--TQITDITNQCLEI-KQ-LLDNGHLD----------------QAQSLLPIEKVY-IPSFIK-----------------
288940281       ------------MPENSVRA-IFDD-KTIRVYQAYRADIALPALAAGRF-VPP-FKMDR--MTWIKPSFGWMMYRSGY-ASK-PGQEFVLGIDITRDGFEWALAHATLSSFKPSVHP-------------------------------------------------SYEVWKADIESK--PVRVQWDPERDWKLQPIRGV---RAVQIGLS-REAIK-YYARDWI--VKIEDVTPLVKKASQA-IIMPPDLP----------------SA-----LERPY-PLPADL-AYIC---CD-------
320095331       ------------QPLRQIRA-LYDA-TTITVYQAYSPAIADAALRAGAF-VPP-FKEER--MTWIKPSFLWMMYRSGW-GTK-PGQERTLAVRITREGFEAALADACLSHFDPDVHS-------------------------------------------------TRQAWSAAVAAC--PNRIQWDPERNASGDPLAH----RSIQIGIG-PARVG-AYAHEWV--VGISDVSDLVEAL-RL-AP-ARLGE--------------------LGPRERPY-PLPAGL-AQRIG--AS-------
256395290       MGN------ENNLPLHQVRA-DYDR-ETIVVYQAYRAQIAEPAVRAQRF-VEP-FSLQR--MTWIKPSFLWMMGRSNW-ARK-PGQEHVLAVRITREGWENALSQAVLTGYKRGVHA-------------------------------------------------DHADWEQQMKHA--RVHVQWDPERTLSGAVLDA----RSIQVGLS-RHVVA-DYVNAWT--TEIRDITPTVRKM-AD-LLKEGRKD----------------RAAQHLPKERPY-ELPPHIA-RRLR--GE-------
238061717       ------------VPVRQIRA-RYSA-ATITVYQAYPPQIALPAVSAGRF-VAP-FKRDR--MTWIKPSFLWMMYRCGW-ATK-PGQERVLSIDITRDGFEWALARACLSHYDRDVHG-------------------------------------------------DKATWSRQLKTS--PVRVQWDPERSLHLNALPY----RSLQVGLS-GEAVD-RYVDDWI--VAVTDITPTVERA-RD-LLRRGDDQ----------------AAAAQLPVEYVY-PLPDRIA-VGLH--AS-------
162457272       AAQSA----RWPTAGRHILA-QFDA-ETIVVYQAYRPSIARHAALHQRL-GGPEFSFGR--MSWIKPNFLWMMFRSGW-GTK-PDQEAVLAIRIQRAGFDAILAAAVPSGFVPDLHP-------------------------------------------------SEEAWKSDLQRS--DVRLQWDPDHHPSGAPVAR----RAIQLGLR-GATLR-RFAEEWT--VGVEDISALVAEQ-RE-VLRGRGVG------------------ELEIPREEVY-WPTAAEAARRVG--IE-------
159037621       ------------VPVRQIRA-RYSA-DTITVYQAYPPQIALPAVAASRF-VAP-FKRDR--MTWIKPSFLWMMYRCGW-ATK-PGQERVLSIDITREGFEWALARACLSHYDRDLHG-------------------------------------------------DKATWLRQLKIS--PVRVQWDPERSLQLKALPY----RSLQVGLS-GEAVD-RYVDDWA--VAITDITPTVHLV-RD-LLRSGDGQ----------------AAAALLPVEQVY-PLPDQIA-VGLN--AS-------
124002814       -------------MQKQIYA-AYDD-EGLFVYQAFKPKVVATAAAKGTF-GTG-FNTNR--LTWIKPSFAWVLQRTKY-ATK-HRMNAIARIKLSHEGWLHLLRQAVPTQYDAQRYT-------------------------------------------------NEEDWQQALDKA--VVIHQWDPERDLLGKKLDR----AAIQVGVR-SEELSLRYVNEWI--LGIEDVTELAHAI-GS-LQKRRNPP------------------LPETPEERLY-PVSEEMA-LALG--CF-------
333374005       MEQME----RWPAEGRHILA-QYDP-SSIVVYQAYKPKIGRFAVDHGYF-GGE-FRFNR--MSWIKPNFLWMMFRSGW-GTK-PDQETILAIHIERSGFDSLLEQAVHSTWNQSLHP-------------------------------------------------DREAWQKDLRKS--EVRLQWDPDHDPFGQPVKR----RAVQLGLR-GETLI-RYARDWI--VEIEDITNFVKKQ-KA-YVDQGKLD------------------RLETPQETVY-PPASVQGRV--------------
168703011       PEQVK----VWPKDGRHILA-QFDH-DSVVVYQAYSPAIGRYAIEHGRF-GGA-FSFER--MSWIKPNFLWMMYRSGW-GTK-ENQEVTLALRLRRAFFESLLAEAVPSTWDRDLFA-------------------------------------------------TFEEWSRAVGRS--AVRLQWDPDHHPSGAKLDR----RAIQLGLR-GRVLE-AFGTTEL--LEVIDLSEFVAQQ-RE-LLAARGTS----------------AL--ITPRERVY-SPTDPAIAAQLR--LA-------
298250918       EDQLK----VWPQQGKHILA-QYDE-TSVVVYQAYRPAIGHFAARRGYF-GGG-FSLER--MSWVKPNFLWMMYRSGW-AQK-EHQEVVLAVRLKRAAFDEILAQAVHSTYKEALYG-------------------------------------------------SHEAWKQALETS--HVRLQWDPDHDPRGVKLER----RVIQLGLR-GPVLA-QYAREWI--LDIEDISQFVYEQ-YH-YVESGAFD------------------QLIMPAERVY-PIVNTHIAARLG--II-------
300854685       -------------MEKKICA-SYTE-NSIRVYQAYNNKVAEECLKLGTF-GES-FKMER--MTWIKPSFLWMMYRCGW-GKK-ENQERVLAIDISRNGFEEMLSNVVLSTYSEKVYK-------------------------------------------------SHENWKFQLKTS--NVRCQWDPERDIYGNKLDR----RSIQIGLQ-GEMVY-KYVNNLI--LNIEDMTNKVSKW-SK-DIRDKKLD------------------FKELPVENEY-YV-DNLI-KEKLGMSI-------
296121824       AEQAE----QWPHEGRHILA-QFDQ-DTIIVYQAYQPAIGHYTAMHRTF-GGG-FSYSR--MSWIKPNFLWMMYRSGW-GTK-ANQEITLALRIRREFFDALLAEAVPSSWDPTEFV-------------------------------------------------TEDEWSQAVSKS--SVRLQWDPDHHPTGAKLER----RAIQLGLR-GDVLK-AFGQQEL--IDVIDISDFVSAQ-RE-RLLSRGTS------------------ALVTPLERVY-SPADPEIALRLK--LA-------
340377247       IEQQTG---VWPKDGKHILA-QYDD-EDIIVYQAYSRGIGSYAIEHQKF-GGPLFSYSR--MSWIKTNFLWMMYRSGW-GSK-ENQEMVLAVRISRNGFDTILSHALTGHDEKLLGK----------------------------------------------------------GQS--PVRLQWDPDHHPDGSALSR----RAIQLGLR-NDILA-RYGDEWT--TDITDISDFVHDQ-YQANVISRQWD------------------KLLVPRERVY-HVTNEEIAKQIK--LI-------
281203630       ------------MKERIIRA-IYDD-TTITLYQAFNSVIGRYAVKNQSFIGCPGFKIDR--MTWVKPSFLWMMYRSGW-ATK-HNQECILAIRIKREGFEWALQNSSLSQHLSISAE-------------------------------------------------QREEHREQLLSQ--PVRIQWDPEKDIDLKALPY----RSIQIGLS-GVAVT-KYLNEWI--VSIEDITPKCKTI-YQ-LLATHQRE----------------EALRQLPQESIY-NIDNHHIEIHIN--LS-------
290974944       M--------ITQQVTGSIIT-IDDE-ECIVFYQAYNSGIADWVVKNQTFDECPNFDKKR--MSWIKPNYLWMMYRSEY-ATA-KNQTNILALFITRKSFEEELLKHAVCAMYYPELE----------------------GYYKSQKEWKVNCSQMKEKVAQLMNKNDTDTI-MTDNVC--FARVQWDPYHTPAFGNING-GLTRAIQIGVK-GSFLR-SMCKSGA-CKKIEDITKYVHEQ-HA-----EYLK----------------TKDLLIPVERYI-HINDKDIKGRLA--IT-------
290974534       -EARN----EWPDDGNHIIA-SYTE-DAVLVYQAFNDEIADYAVKHQKFDGCPSYNDTR--MTWVKSNWLWMMYRSNY-ATK-QNQTRILGLWLKKSAYDDILKKARLKGAGAGL------------------------------------------------------------------TRAQWDPDYSPELEPIKRR---RDLQLGIK-KRETF-RNGEDF---VEIVDCTELAHIS-KK--T-------------------------KTIPHERVYTPDNEVCI--NLQ--VS-------
83647694        LEQTS----LWPASGRHILA-HQDQ-DTLIVYQAYRPEIGEYAIKHGRF-GGA-YSYSR--MSWIKPNFLWMMYRCGW-GMK-EGQEVVLGLRIRRQFFEDILSQAVPSSYNPEEFA-------------------------------------------------TQETWKEAVQNS--NVRLQWDPDHTPNGAKCER----RAIQLGLR-GDMLA-RYGKEEI--LEVIDFREFIAEQ-RA-QATPDRYA----------------EL--LTPQEQVF-IPSDDAIGARLR--LD-------
294669065       ------------MNQNTIRA-VYGE-HTIRVYQAYSDPIADAALAHGTF-VSPPFKMER--MTWIKPSFLWMMYRAGW-GLKDEGQKRILAIDISREGFEWALRHACLSHPPAGMGK---------------------------------------------------DDWQRLKAQS--PVRIQWDPERDLQLKALPY----RSIQIGLS-GEAVN-YYVNDWI--QDITEITPLARQI-RE-LVEQNRLD----------------EAQILLPPEQPY-PAVYVPI----------------
21223327        ----------MQQPQREVRA-VHTA-STVTVYQAYSPEIGLPAIREGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-AAK-AGQETVLAVEIGREGFEWALRHACLSSYQPGVHP-------------------------------------------------DRATWQREVKRS--PTRVQWDPERDLRLQPLPY----RSLQLGLA-GEAAR-RYADEWT--VAIRDVTPLAHEI-HG-LVRDGDLD----------------AARRLLPREQPY-PAAEELL-SNLRP----------
297561069       ----------MDVPRHQIRA-LHTD-STVTVYQAYAPSLGLAAAREGRF-PSA-WKRDR--MTWIKPSFMWAMYRSGW-GLK-RDQETVLAVEITRAGFAWALRNACLSHHAPAVHP-------------------------------------------------DRETWRARLREA--PARVQWDPERDLYLSPLEH----RSLQLGLA-GEAAR-RYADEWI--VSITDVTPLARRV-HT-LVQEGDTA----------------AAARLLPAERPY-PVAQGEL-DHLRPARE-------
333027909       -----------PVPRHEIRA-LHTA-DTLTVYQAYRPSLGVPAARDGRF-PEA-WGRGR--MTWVKPSFLWMMYRCGW-GTK-EGQETVLAVEIAREGFLWALRNATLSHFERGVHG-------------------------------------------------DRAEWQRSLRRA--PARVQWDPERDLHARPLEH----RSLQLGLS-GEASR-RYADEWI--VGIRDVTPLAREA-HG-LVRDGELD----------------GARALLPVERPY-EVPVDAL-AGLLP-VP-------
295839520       PPPAAS---PPEIPRHQVRA-LHTA-DTLTVYQAYRPSLGLPAARDGRF-PPE-WGRER--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAVEITRAGFLWALRHAALSHYEAATHG-------------------------------------------------SREAWRRALRGA--PARVQWDPERDPRGRALAH----RSLQLGLS-GEASR-RYADEWT--VGIRDVTPLAREA-HA-RVREGRPE----------------AARALLPVERPY-EVPADAL-AGLLP-AP-------
297202026       --------------MG------------------------ALRRRTEPWNPPRERVCEHA-LTWIKPSFLWMMYRCGW-GAK-AGQETVLAVEISRDGFEWALRHACLSSHVRGAHP-------------------------------------------------DRAAWQRQLKRA--PARVQWDPERDLHLRPLPY----RSLQLGLS-GEAVR-RYADEWT--VAIRDVTPLAHEI-HA-LVRGGDMA----------------SATGLLPQERPY-PAEAESL-AHLLA----------
312886331       KQSLT----LLPQNGQHILA-HQTG-NDMVVYQAYKPGIAKFAVDNQFL-GGPDFSFTR--MSWIKPNFLWMMYRCGW-AEK-ENQERVLAIWIAQKDFEEILRQAVFSSFNPQYYR-------------------------------------------------DHDHWKNELSLK--EVRLQWDPDHDPYGNKVER----RAIQLGLK-GEMLR-FFSSK-I--KSIEDITDFVNQQ-KN-LLDHHGLD------------------ELEVPVETIF-KTSDPIL-NKQIG-IT-------
297194315       ---------MTDEPRHRVRA-RYTD-DTVTVYQAYSPAIGVPAARDGRF-PAA-WKRER--MTWIKPSFLWMMYRCGW-ATK-ADQETVLAVEIRRDGFEWALRNACLSHYQEGVHE-------------------------------------------------SREAWKRELRQA--PARVQWDPERDLRLNPLPY----RSLQLGLG-GDAAG-RYADEWT--TGITDVTPLARQM-RR-LVLEGDLA----------------GAGRLLPEERPY-PADTGLL-GHLVPSAG-------
297162424       M--------AMQEPRHQIRA-LHTE-STVTVYQAYAPHLGLPAARDGRF-PTA-WKRDR--MTWIKPSFLWMMYRCGW-GAK-EGQETVLAVEITREGFEWALGRSCLSHYERGLHP-------------------------------------------------DQAAWKRALKAA--PARVQWDPERDLRLRPLPY----RSLQLGLS-GGAAR-RYADEWT--VAITDVTPLAHEV-HA-LVRRDELD----------------AAVRLLPEERPY-PAGDELL-SHLRAPVA-------
328884339       MEETRT---ADDEPKYRIRA-LHTD-RTVTVYQAYRPEIGLAAAREGRF-PAI-WKRDR--MTWIKPSFLWMMYRSGW-GTK-EGQETVLAVEITREGFEWALRNACLSHHVRGFHP-------------------------------------------------DQATWKARLRTA--PARVQWDPERDQRLRALPY----RSLQLGLS-GEASR-RYADEWT--VSVTDVTPLAHRV-RD-LVRAGDLE----------------AAGRLLPREEPY-PESAGLL-EHLRVPQA-------
297202028       ----------MEEPLHRIRA-LHTA-STITVYQAYRPEIGGPAARKGRF-PAA-WKPDR--MTWIKPSFMWMMYRSGW-GMK-ESQETVLAFEITREGFDWALRHACLSHYVRGLHP-------------------------------------------------DRDTWQRDLKRA--PARVQWDPERDLHLHPLPY----RSLQLGLS-GEASS-RYADEWI--VSISDVTPLAHEI-HA-LVRDGELD----------------SAARLLPQEQEY-PANAELL-AHLCP----------
291438820       --------------MA----------RRPRRCSLHRDDGSLPALTQAGW--AHEKVCERG-STWIKPSFLWMMYRCGW-GTK-EGQGTVLAVEITREGFEWALEHACLSHYEQGLHG-------------------------------------------------DRATWKRRLERA--PARVQWDPERDLRLQPLPH----RSLQLGLA-GEAAR-LYADEWI--VSITDVTPLAHAV-HA-QVRSGDLD----------------IARQLLPRERPY-PMNDELL-AHLHQ----------
329935335       ----------MAPPQREVRA-AHTD-ATVTVYQAYAPEIGVPAAEAGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-QGQETVLAVEISREGFEWALRHACLSSYAPGVHP-------------------------------------------------DRTTWQRELKRA--PTRVQWDPERDLYLRPLPY----RSLQLGLA-GEAAR-RYADEWT--VSLTDVTSLAHEI-HA-LVRDGDTD----------------SAARLLPRESPY-PGQDELL-ARLRG----------
345013407       ----------VAEPKYQIRA-LHTE-STVTVYQAYAPEIGLPAAREGRY-PAV-WQRDR--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAAEISREGFEWALEHACLSHYEHGLHA-------------------------------------------------DRATWKRQLKRA--PARVQWDPERDLHLQPLAH----RSLQLGLT-GEAAR-LYADEWT--VSITDITSLAHTI-HA-HVQGGDLD----------------AARQLLPRERPY-PVNEGDL-AHLYQ----------
302548144       ----------MEDQNHQIRA-RHNP-ATVTVYQAYAPHIGLPAARDGRF-PSA-WKRDR--MTWIKPSFLWMMYRCGW-GLK-EGQETVLAVEITHEGFAWALRNACLSHYVRGLHP-------------------------------------------------DQAAWKRQLHRS--PTRVQWDPERDLQLRPLPY----RSLQLGLA-GEAAR-RYADEWT--VSITDVTPLAREV-HA-LVRAGDLD----------------AAAARLPEERPY-PAADDLL-SHLRVPRP-------
330801102       ----------MSGYKRIINA-VYDD-ETVRVYQAYKATIADDAIKNQRFTEASGWKQDR--MTWIKPSFCWMLYRSGY-ATK-HNQERILAIDIKRSAFEWILENHIDSTETAKSSI------------------------------------------------------PSEKK----KIVVQWDPERNFKIGKIDGCGDVRSIQIGIK-AVKTK-EYNEDWI--VRIQDVTDLAHQI-KE-LVELKDFE----------------KANALLPNERIYKPKNVRFN----------------
291453417       TNPT-----ALPHPTHQIRA-RQTP-TTVTVYQAYPPSIALPAARDQRF-PAA-WKRDR--MTWIKPSFLWMMYRSGW-SRK-EGQERVLAVEISRAGFDWALGHACLSAYHPDVHA-------------------------------------------------GRDGWREALRGA--PARVQWDPERDWRLRPLPW----RALQLGLS-GEAVR-RYAEEWL--VSVVDVTGLAHAV-QE-RVRAGDEA----------------GARELLPEERVY-VPEGGLP--ASLVG---------
29829850        ----------MEETQRRIRA-VHTT-STITVYQAYSPEIGLPAVREGRF-PTA-WKRDR--MTWIKPSFLWMMYRCGW-GAK-AGQETVLAVEITRDGFEWALRHACLSSYVRGVHP-------------------------------------------------DRATWQRQLKHA--PTRIQWDPERDLHLQALPY----RSLQLGLA-GEAAR-RYADEWT--VSISDVTPLAREI-RT-LVGNGDLD----------------SAARLLPQELPY-LPADELP--AHLRP---------
332668288       -------------MCTNIIG-YQTE-EEIVVYQAYKPEIAKFAVENQKL-GGASFGFQR--MSWIKPNFLWMMYRCGW-AEK-ENQEHVLAIWIKKQDFELILEQAVLSSFQKEIYH-------------------------------------------------TEEDWKLQLSQS--EVRLQWDPDHDPKGNKLER----KAIQIGMK-GEMLH-LFANKYI--QHIEDITTFVRKQ-KL-YVDRRELE------------------KLLIPKESIF-TSLSAQR-KTHTL-AT-------
260802161       VSQIDH---HWPPTGKHILA-QYDD-NSVVVYQAFRPEIAEYAVKNQRF-GGSHYSWER--MSWIKPNFLWMMYRCGW-ASK-KGQERVLAVRITRTGFDEILANAYTPKTQAEAGL-------------------------------------------------PKDQL---------KVRLQWDPDHDPSGTSVQR----RAIQLGLK-GEILS-HFAQDWI--VSITDVTDFVHEQ-HN-VLQTSGTE------------------QLQVAAERVY-QVTDPKT-KALIG-VE-------
260782199       VSQVQQ---HWPQTGKHILA-QYDD-NSVVVYQAFRPEIAEYAVKNQRF-GGPHYKWER--MSWIKPNFLWMMYRCGW-ASK-KAQERVLAVRITRNGFDEILANAYTPKTQAEAGL-------------------------------------------------PKDQL---------KVRLQWDPDHDPSGTSLQR----RAIQLGLK-GEILN-HYAQDWI--VSITDVTDFVHEQ-YN-VLQTSGTE------------------QLQVAAERVY-QVTDPKT-KALIG-VE-------
158335219       LHQKD----RWPQQGRVILA-QYDT-DSIVVYQAYRPAIGNFAAQHGYF-GGE-FKLSR--MTWIKPNFLWMMYRSGW-GAK-PGQEVVLAIRLQRSAFDSILAQAVHSSFQSGLYD-------------------------------------------------SQESWQKAVQTS--DVRLQWDPDHNPAGHKLER----RAIQLGLR-GDAIR-KYAQEWI--LDIEDISDFVADQ-RQ-HVVSGNYE------------------ALLTPAEAPY-PVSDLKT-AHRLQ-VP-------
72006229        CDQNNV---CWPIAGKHILA-QFDE-HSVVVYQAFCPAIAKYAVDHQRF-GGDKFSFSR--MSWIKTNFLWMMYRCGW-ASK-PNQERVLAVRITREGFDEILSKAYTPQTQATAGL-------------------------------------------------GKEEI---------EVRLQWDPDHAPNGDKMDR----RAIQMGLK-GETLR-KYATEWI--VSIRDVTDFVKEQ-SK-NTDRKRLN------------------LLDVAQERVY-PVSNPKT-AQLIG-LG-------
300867123       LTQVS----RWPKAGRHILA-QFDE-NSIVVYQAYRPAIGDFAALHGYF-GGE-FKLSR--MSWIKPNFLWMMYRSGW-GTK-EGQEVILAVRLKRSAFDEVLTAAVHSTFVSEVYA-------------------------------------------------SEKEWKQAAKNS--SVRLQWDPDHHPNGSQEER----RAIQLGLR-GEILV-HYAQDWI--INIEDISEFVQEQ-HQ-NLKEG-MA------------------NLLTPSEEVY-PITNSDT-AKRLQ-IS-------
291237935       MEIMK----LWPKNGNHVLA-QYDD-HNIVVYQAFCPEIANYAVKNQRF-GGPHYSFDR--MSWIKPNFLWMMYRCGW-ATK-SKQERVLAVRITREGFDSILSKAYSAQAQKAAGL--------------------------------------------------------NKNDI--QVRLQWDPDHKPSGAPTLR----RAIQLGLK-GEILR-KYATEWI--VSIEDVTPFVQEE-MV-KLTPENID------------------KLVVPIEKVY-HVTDKKT-ANLIN-VE-------
307105263       VRQEAE---FWPAVGRHVLA-QATE-DTVVVYQAYTPSIGVLAAGQGDFRGIPGFSETR--MTWVKTNFLWMAFRCGW-ASK-PNQETVLAITLKRPFFERMLAASLSTSAGTTAKG----------------------------------------------------------PCIGADVVLQWDPDHLPDGSKHPGR---RAVQLGLR-GGVRD-EYISGRH-TVCIEDITPFVREM-GA-IAAGGEPR----------------WVGLLVPSERVL-RLRD-EV-RSHIA-AD-------
149922143       LEQRE----RWPQTGRHVLA-HYDD-EAVVVYQAYNPAIAAWAVKHQRF-GGP-WSFER--MSWIKPNFLWMMFRCGW-ATK-RDQERVLAVHLERAGFDAILGQAVHSSFVAERYA-------------------------------------------------DRATWQARGRRS--DVRLQWDPDHGPRGGKLER----RAIQLGLR-RATLR-AFAEGWC--RGIEDITPFVHAQ-RT-FVDSRQLG------------------RLQTPLERVY-PVLDAEV-AAHLG-VT-------
299472429       S--------APTATGRCLLA-QFTD-REVIVYQAYKPELGNFAVENQYF-GGDGFNFKR--TSWVKPNFTWMMHRCGW-ASK-QNQEVVLALALRRDFWDDVLSQAVMSNYESYRST-------MSAEVPR---------------------------------GDAQRRWKASLQAS--DVVMQWDPDHMPFTGHKTNH---RAIQLGLR-GDALA-AFRGPAFGETGIQDVSAFAKAT-EE-IHRPRAADGGGGGGHPDAPAATPPPPALLLPIEETY-PVVDASV-AQRLG-ID-------
170940179       TM-------STPTPYKQIRA-LHTP-RSITLYQAYNHPIASAAVSAQSLTASPLFKTTR--MTWIKPSWAWMLYRSGY-SFKDANQSRILALTMSHEDFLWLLSQGVVSHRSPEEKG-----------------------------------------------------DQGGKKLG--GVRIQWDPERDVKMERMGY----RSIQIGIPGGEVCE-RWVG-MV--KKIEDVTDKAREL-KR-VIDERPEV-----------TVGVLKEMGLVPEEKVF-EIEDEEV-RRRLG----------
87310926        -----------MFHFREIRA-SFDR-DTIVVYQAYNDAIANAALTVGKF-VPP-FSFQR--MTWIKPSFLWLMERSGW-GTK-ANQTRILAVRIARSGWDAAIGQGVLTSYHSDIHR-------------------------------------------------SQDDWRTQFENA--MVHVQWDPERSLRGKKLEY----RSIQVGVG-RRLIT-EFAEQWT--QEIVDLTPLTAKL-RQ-FRQAGDHD----------------KAKRLLPRESIY-RVNNAT--ASRLG-IE-------
238020853       ---------MT-TPPKQIRA-VYTD-TTIRVYQAYSDAIADTALAAGRF-VSPPFKMER--MTWIKPSFLWMMYRAGW-GGKDDNQKRILAIDISRSGFEWALHHACLSHPPAGMDS---------------------------------------------------ATWQQTKAAH--PVRIQWDPERSLKLEPLPH----RSIQIGLT-GEAVP-RYVNEWI--QNISEITDVVQEI-HA-LIAQDNLA----------------AAQALLPPERVY-PFDWET--DFQAA----------
239815282       MK-------TDVIPHNQIRA-MYDA-DTIRVYQAYSDAIADSALAQGRL-VSPPFKLER--MTWIKPSFLWMMYRAGW-GLKDEGQKRILAIDITREGFEWALAHSCPSHSPEGMSG---------------------------------------------------EEYAALKQRC--PVRVQWDPERDLHLQPLAH----RAIQIGLS-KEAVR-LYVNEWT--CKITEMTALAHEV-QA-LVQQGQLQ----------------KAASKLPMERAY-PGQQAT-----------------
254392683       -----------MVALRQIRA-QYDD-RTIVVYQAYSSAIAEPALRAGTF-VPP-FSFGR--MTWIKPSFLWLMHRSNW-ARK-PGQERILAVRITREGWEEALSQAVLTTSHPDRVA-----------------------------------------------------------QA--PVHVQWDPERSLRGAALNH----YSIQVGVG-RGLIE-RYAKEWV--VGITEVTSQARKA-AE-LAQGGRAE----------------KAKRLLPPERPY-PVPRAT--AQRLD-ID-------
295658070       MDQP-----NVAPTKYAIRA-QYTS-KTITVYQAYSPAIANAALSAGKF-VAP-FKRVR--MTWIKPSFLWMAYRCGW-ATK-KDQERVLAIEITREGFEWALAHACLSHPTPRLYA-------------------------------------------------DHAAWEHRKNES--SVRVQWDPERDFEFRPLEY----RSLQVGLK-EEAVD-RYVDEWT--VGIRDVTWLMQEI-GQ-LVREGKIE----------------EARRKMPVEEVY-VLPTDV--ATVVG-AD-------
302504024       M--------TDNNPYRAIRA-KFTE-NTITVYQAYSNEIADAALGAGTF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DKSAWESRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GEAVD-QYVDEWI--VSITDITEQIRKV-SG-LVSSGQLG----------------EAKKQMPEECLY-DLPGDV--GEMIG-AS-------
239606461       MESQQPL--KAGPSNYAIRA-QHTP-TTITIYQAYSPSIANAAVAAGKF-VAP-FKR----MTWIKPSFLWMAYRCGW-ATK-KDQKRVLALEVTREGFHWALAHACLSHPSPHLYA-------------------------------------------------DQATWEKRKEES--PVRVQWDPERDFEFRALEY----RSLQVGLK-GEAVD-RYVDEWI--VGIRDVTGLMREV-GR-LAGEGRLD----------------EAREMMPVEEEY-VLPADV--ARVIG-AD-------
303312351       M--------SREQGYRAVRA-KFTA-ETITVYQAYSAEIASPALRAGKF-VPP-FKRTR--MTWIKPSFLWMAYRSGW-ASK-PNQERVLAIEISREGFEWALFNSFVNSHDKSLYP-------------------------------------------------DKHAFEHRKQNT--CVRVQWDPERDFGFTPLSY----RSIQIGLS-GEAVD-RYVDEWI--VSIQDVTDRMVKM-GQ-LVAAGKIE----------------EAQKLMPIEEPY-PLPKQV--GAAVG-AS-------
302657470       M--------TDSNPYRAIRA-KFTE-NTITIYQAYSNEIADAALGAGTF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DKSAWESRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GDAVD-RYVDEWI--VSITDITEQIRKV-SG-LVSSGQLG----------------EAKKQMPEECLY-DLPDDV--GEMIG-AS-------
326470706       M--------TDNNPYRAIRA-RFTE-NTITVYQAYSNEIADAALGTGTF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DRSAWVLRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GEAVD-RYVDEWI--VSITDITEQVRKV-SG-LVSSGQLD----------------EAKKQMPEECLY-DLPGDV--GEMI-----------
302411952       DH-------SSPTPPRQIRA-DFDD-TTITLYQAYSAAIAEPAVAAQKLTAAPSFKPTR--MTWVKPSWAWMLYRAGY-SFKDAGQERILALKMRHADFLALLRRGVLASQATTAEG---------------------------------------------------------------EVRVQWDPERTVRLDKLPH----RSIQIGIP-RGLSQ-QWADEWV--VGIEDVTDRARKL-KD-VLDVRPGV-----------SNAELLEMGLVPAERVY-QVPEDV--IRRLC----------
336117044       ------------PPFRQVRA-VHDE-DTITVYQAYSPAIASAAVAAGGF-VPP-FRRER--MTWIKPSFLWMMYRCGW-ATK-PGQERVLAIRMLRSGFEEALSMASLSHFDPAVYA-------------------------------------------------DQEVWQQRKAAS--PVRVQWDPERDVRLEPLAW----RSLQVGLG-GVAVE-RYVDDWV--VGIEDITAMVEEL-RE-RAPDDRRS--------------------SLPIELPY-PLPPEV--AAVVG-AT-------
119193120       M--------SREQGYRAVRA-KFTA-ETITVYQAYSAEIASPALRAGKF-VPP-FKRTR--MTWIKPSFLWMAYRSGW-ASK-PNQERVLAIEISREGFEWALFNSFVNSHDKSLYP-------------------------------------------------DKHAFEHRKQNT--CVRVQWDPERDFGFSPLSY----RSIQIGLS-GEAVD-RYVDEWI--VSIQDVTDRMVKM-EQ-LVAAGKIE----------------EAQKLMPIEEPY-PLPKQV--GAAVG-AS-------
240272965       MEQP-----KTSPSKYAIRA-QYTP-TTITVYQAYSPAIANAAVAAGKF-VPP-FRRGR--MTWIKPSFLWMAYRCGW-ASK-KNQERVLAVEITREGFHWVLAHACLSHPSPRLYV-------------------------------------------------DQATWEKRKDAS--PVRVQWDPERDFEFRPLEY----RSLQVGLK-GEAVD-RYIDEWI--VGIKDVTGLMQDV-GR-LVSEGQLE----------------EAKRRMPVEEEY-VLPEDV--ARIIG-AD-------
225559493       MEQP-----KTSPSKYAIRA-QYTP-TTITVYQAYSPAIANAAVAAGKF-VPP-FRRGR--MTWIKPSFLWMAYRCGW-ASK-KNQERVLAVEITREGFHWALAHACLSHPSPRLYV-------------------------------------------------DQATWEKQKDSS--PVRVQWDPERDFEFRPLEY----RSLQVGLK-GEAVD-RYIDEWI--VGIKDVTGLMQDV-GR-LVSEGQLE----------------EAKRRMPVEEEY-VLPEDV--ARVIG-AD-------
342875667       MPTA-----PSTAPYRQVRA-CYND-TTIIVYQAYKESIAKAAVDAQKLNASPDFKSGR--MTWIKPSWAWMMYRAGY-SYKDPGQSRILALRMKHEYFITLLERGVLSSHAHKLNP-----------------------------------------------------GEKRETTV--DVRIQWDPERTAKLEVLPY----RSIQIGIP-GALSK-QWANEWI--VEIEDVTDKAREL-KR-VIDERPGI-----------TDEELLNMGLIFEERPF-EVPEAV--HTKLE----------
327352957       MESQQPL--KAGPSNYAIRA-QHTP-TTITIYQAYSPSIANAAVAAGKF-VAP-FKRGR--MTWIKPSFLWMAYRCGW-ATK-KDQKRVLALEVTREGFHWALAHACLSHPSPHLYA-------------------------------------------------DQATWEKRKEES--PVRVQWDPERDFEFRALEY----RSLQVGLK-GEAVD-RYVDEWI--VGIRDVTGLMREV-GR-LAGEGRLD----------------EAREMMPVEEEY-VLPADV--ARVIG-AD-------
296821722       ---------MTDNLYRAIRA-KFTD-DTITVYQAYSDEIADAALGANTF-VSP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDESLYR-------------------------------------------------DKSAWEARMQAS--CVRVQWDPERDFNFTPLNY----RSIQIGLK-GEAVD-RYVDEWI--VSIADATEQIRTV-SR-LVSSGRLS----------------EAGKELPEEKLY-DIPEDV--AKIIG-AS-------
302922871       TSTSP----DTSIPYHQIRA-HYDG-KTITVYQAYKESIARDAVAAQKLNASPDFKPGR--MTWVKPSWAWMMYRAGY-SYKDSRQSHILAIRMKHEHFIGLLERGVLSKHAKKAPE---------------------------------------------------DSTVKREKTS--DVRIQWDPERTPKLGVLPY----RSIQIGIP-GALST-QWADEWI--FEIEDVTDKAREL-KR-VIDERPDI-----------TEEELLELGLIFEERPF-EVPESV--GERLE----------
315054759       ---------MADNPYRAIRA-KFTE-NTITVYQAYSNEIADAAMRARTF-VSP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PDQERILAIEITRSGFEWALRNACLSHVDNSLYR-------------------------------------------------DKSAWESRMQSS--CVRVQWDPERDFYFNALSY----RSIQIGLK-GEAVD-RYVDEWI--VSITDVTEQIRKV-SE-LVSSGELG----------------GARKEMPEERLY-GIPEDV--GAMIG-AS-------
226293790       MDQP-----NVAPTKYSIRA-QYTS-KTITVYQAYPPAIANAALYAGKF-VAP-FKRRR--MTWIKPSFLWMAYRCGW-ATK-KDQERVLAIEIAREGFEWALAHACLSHPTPRLYA-------------------------------------------------DHAAWELRKNES--PVRVQWDPERDFEFRPLEY----RSLQVGLK-EEAVD-RYVDEWT--VGIRDVTGLMQEI-GQ-LVGEGKIE----------------EARRKMPVEEVY-VLPTDV--ATVVG-AD-------
327308048       M--------TDNNPYRAIRA-KFTE-NTITIYQAYSNEIADAALGAGAF-VAP-FKRGR--MTWIKPSFLWVAYRSGW-ATK-PNQERVLAIEITRSGFEWALRNACLSHVDNSLYK-------------------------------------------------DKSPWESRMQAS--CVRVQWDPERDFHFNPLGY----RSIQIGLK-GEAVD-RYVDEWI--VSITDITEQIRKV-SD-LVSSGQLG----------------EAKKQMPEKCLY-DLPGNV--GEMIG-AS-------
225684169       MDQP-----NVAPTKYSIRA-QYTS-KTITVYQAYPPAIANAALYAGKF-VAP-FKRRR--MTWIKPSFLWMAYRCGW-ATK-KDQERVLAIEIAREGFEWALAHACLSHPTPRLYA-------------------------------------------------DHAAWERRKNES--PVRVQWDPERDFEFRPLEY----RSLQVGLK-EEAVD-RYVDEWT--VGIRDVTGLMQEI-GQ-LVGEGKIE----------------EARRKMPVEEAY-VLPTDV--ATVVG-AD-------
315506327       ------------VPRHQIRA-AYTG-TAVTVYQAYPPEIADAALRAGRF-VPP-FKRER--MTWIKPSFRWMMYRCGW-ALK-PCQERVLAVDISRAGFEWALRHACLSSYDPRLHP-------------------------------------------------DRDAWRHSLRVS--PVRVQWDPERSLRLAPLPY----RSLQVGLT-GDAVR-RYVDEWV--VGLTDVTGLARSV-HG-RLTDGDEA----------------GAAALLPVERLY-PLPAEVA--RVVD-AG-------
302867267       ------------VPRHQIRA-AYTG-TAVTVYQAYPPEIADAALRAGRF-VPP-FKRER--MTWIKPSFRWMMYRCGW-ALK-PCQERVLAVDISRAGFEWALRHACLSSYDPRLHP-------------------------------------------------DRDAWRHSLRVS--PVRVQWDPERSLRLAPLPY----RSLQVGLT-GDAVR-RYVDEWV--VGLTDVTGLARSV-HG-RLTDGDEA----------------GAAALLPVERPY-PLPAEVA--RVVD-AG-------
258574383       M--------STSHPYRAIRA-KFTP-DTITVYQAYSAEIALPAVRAGKF-VAP-FKRTR--MTWIKPSFLWMAYRSGW-ASK-PNQERILAIEISRAGFEWALLNSFVNTHDPAFYG-------------------------------------------------DHRALEERKRNT--CVRVQWDPERDFGFEPLPY----RSIQVGLS-GEAVE-RYVDEWI--VAIEDVTELMVGM-GR-LVAEGKIE----------------EARELMPVEKAY-PLPEEVA--KVVG-AS-------
310796940       GH-------RPPTPFRQIRA-RFDE-ESITVYQAYNSAIAAAAVEAQRLDASPGFKVTR--MTWIKPSWAWMMYRAGY-SFKDPGRERILALKMRHGDFVDLLRKGVVARRGNESRD-----------------------------------------------------------GR--GVRIQWDPERDVRLGRLQR----RSIQIGTP-----------------------PRYLEL-KR-VLEERPGV-----------GDGELIDLGLLPAEKEF-EVPKDVE--ELLE-MN-------
269121733       --------------MRKINA-LYDD-DTVRVYQAYRNEIADEALELGTF-GSH-FKRTR--MTWIKPSFLWMMYRAGW-AEK-EGQERILAIDITKDGFLTILKNSVLSHYDRKVYE-------------------------------------------------KAEEWELDKRNF--SGRCQWDPERNIFGSPLEF----RAIQLGLK-DEIVE-SYIKKWI--VNIEDITPMVRKI-KK-MRDEGKDI------------------KEYLPVEKELRIEDSEVI--KRLR-ID-------
290961991       PTEDL----APTEPKFRIRA-RHTT-DTITVYQAYRPEIGGPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GMK-EGQETVLAVEIGREGFEWALRHACLSHFVPELHT-------------------------------------------------DQAEWKRRLRRA--PARVQWDPERSLRLGPLPY----RSLQLGLV-GEAAA-RYADEWI--VGIEDVTPLAREV-HG-HVRAGALD----------------RAAALLPQEPPY-PVAEDVL--AHLR----------
294628199       MNDHH----AEAEPRFRIRA-RHTD-TTVTVYQAYRPQIGGPAARTGRF-PAD-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAVEIRRDGFEWALRNACLSHHVPALHG-------------------------------------------------DQASWRRRLREA--PARVQWDPERDLHHNPLPY----RSLQLGLA-GPAAA-RYADEWI--TGIEDVTPLAAEI-HA-LVRTGELE----------------RATALLPKERPY-PVADEVL--AHLR-A--------
302549980       MN-------DRNEPRFRVRA-RHTE-STITVYQAYRPEIGGPAARDGRF-PAA-WKRDR--MTWIKPSFLWMMYRCGW-GTK-EGQETVLAVEISRDGFLWALRNACLSHHVPALHG-------------------------------------------------EQADWKRQLRRA--PARVQWDPERDLRLAPLPY----RSLQLGLA-GEAAA-RYADEWI--VGIEDVTPLATEV-HA-LVRAGELD----------------AAAGLLPEERPF-HVDDEVL--ARLG-AR-------
300774505       KEQLL----EWPQQGYHIMA-QYDD-EKIIVYQSYRKEIGEFAVKNQFF-GGG-FSLER--MTWIKPNFLWMMYRNGW-GKK-EGQECVLAIHLKKEAFKNYLENAVYSSYNKKLGI-------------------------------------------------SREEWQDQIKES--SVRLQWDPDHDPFGNKLER----RAIQIGLR-NEFTR-SFAKDDI--ILIKNISDFVKEQ-YQ-FVLNDDLD------------------NLIVPEEKPL-LFD-EVL-NKKLN-LR-------
320010749       MND------RTGPPRHEIRA-RHTD-STVTVYQAYRPAIGLAAARDGRF-PSE-WKRDR--MTWIKPSFLWMMYRCGW-GAK-EGQETVLAVEISREGFGWALENAELSHYVRGVHA-------------------------------------------------DRATWQRDLRRR--PTRVQWDPERDLHLNALPH----RSLQLGLS-GEAAR-RYADEWL--VSVTDVTPLAHEI-HA-LVRAGETD----------------RASALLPVEEPLTGLQAPVP-ADR------------
298248426       LTQRE----NWPDEGRHILA-QYDE-QSVVVYQAFKPTIGRFAAMHGFF-GGG-FRLDR--TSWVKTNFLWMMYRSQW-GTV-PQQEIVLAVFLKRDAFDWLLSQAVHSLYHADLYP-------------------------------------------------SDTAWYAQLRRS--PVVLQWDPDHAPTGHRLSR----SAIQLGLR-GEALA-KYAREWI--VAIEDISDFVAQQ-RL-FVQTKAFE------------------QLQVPYETVY-PVADPVV-AARLL-LA-------
299472531       LFSEAKA--HWAAPYRQVFC-QHDK-DTVVLFRACCEHLGPHATATQCFRGSPCYEKDRTRMMWFDSSFLVSMRKSEW-GTK-KGREVVLAIWVKRSFIEDCFGMAVCSNTFGPSCGGGGGGNGSSGGRKGSGGIGRRSSFAVTPFPTSDSGGDDGRSPPTSGFPTPVNSVAGSPPASPVSGQQHQRREQEATASESE---GGRASG-----GDGAR-DDARRAA--AAAATSTALLSKG-QA-SLAQGNEN---------------DEDDDNIPRGRAVTGDPSTRY---YFG-GSAGDPLG-
271967482       ----------MNMPHRQIRA-AYTE-KSITVYQAYDPAVAEPAVAAQRF-VAP-FKRER--MTWIKPSFLWMMYRCGY-ATK-PGQTRVLAIDLTRAGFEWALAHSCLSHPGRDGDQ---------------------------------------------------ETWKERLRHS--PVRVQWDPERDPHHNALPH----RSIQIGLS-GQAVD-RYLDDWT--VSITDITDRVRDV-HT-ALRDGR------------------DVTALLPPERPY-PVPVELA--RTIG-ATAGGDAG-
consensus/90%   .................lbA...s..psl.lYQAa.s.lu..Ah....hs....ap..R..MoWlKPsahWhhaRssa.u.K...Qp.lLAlclp+..a..hL.puh.sp.......................................................................s.hQWDP-+s.....l......RulQlGl.........a.pph.....lpDlo..h........h..........................bhP.Ep.h........................
consensus/85%   .................lbA..as..psl.VYQAY.s.Iu..Ah...pFs.s..ap..R..MoWlKPsFhWhhaRssa.u.K..sQp.lLAlclp+.sa..hL.puh.op............................................................b..........s+lQWDP-+s.....l......RulQlGl....h...paspch.....lpDlT.bhpp......l..........................bhP.Ep.a........................
consensus/80%   ................pIbA..as..pol.VYQAYps.Iu..Ah...pFs.ss.apbpR..MTWIKPSFhWMhYRsGW.u.K..sQcplLAlclpRpsFc.hL.puh.op............................................................hp.....s...s+lQWDP-+s.....L......RulQlGl..sphhp.pasp-W...h.IpDlTsbhpph.....l..........................bhP.Ep.a..hs....................
consensus/75%   .............s.ppIbA..as..pol.VYQAYps.Iu..Ah...pFs.ss.apbpR..MTWIKPSFLWMhYRsGW.u.K..sQEplLAlclpRpuF-.hL.puhlSp........................................................s...Wp..bp.u..slRlQWDPERshp.p.L......RulQlGlp.sphhp.pasp-Wh..lsIpDlTsbhpch.p..hl..sp......................hlP.Ep.Y..hs....................
consensus/70%   h............s.+pI+A..as..pTlsVYQAYps.IupsAlp..pFs.ss.FpbsR..MTWIKPSFLWMMYRsGW.upK..sQEplLAlcIpRpuF-bhL.puhlSp....h...................................................sp..Wpp.bppu..sVRlQWDPERshp.psLsb....RolQlGlp.uphhc.cYsp-Wl..lsIpDlTsbhcch.p..hlppsp.p....................hlP.EpsY..ls.......h............
consensus/100%  ......................................................................................................h.................................................................................pb..................s...G...............................................................................................
consensus/95%   .................lbu...s....l.lYQAa...lu..Ah....hs....a...R...oWlKssa.Whh.Rssa.u.K...Qp.lLul.h.+..h..hl..s..s..........................................................................hQWDP-+......h......bulQlGl.........a.pp......l.-ho..h.....................................s.E..h........................
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    Multiple Sequence Alignment of the RNxxxH family

    This domain is found close to a PARP gene in our operons and may be associated with NAD or ADP-ribose processing

    ALIGN	        -----------H-HHHHHHHHHHHHHH--------------HHHHHH-HHHHHHHHH---------------------------------------------------------------------------H-HHH---HHHHHHHHHH---EEEE-------HHEEEEEE-------------EEEE-----H--------HHHHHHHHHHHH---
HMM	        ---------HHHHHHHHHHHHHHHHHH---------------HHHHH-HHHHHHHHHHHHHHH------------------------------------------------------EEEE-----------HHHHH---HHHHHHHHHH---EEEEE-----EEEEEEEEEE------E----EEEEEEEHHHH--------HHHHHHHHHHH----
FREQ	        ------------HHHHHHHHHHHHHH---------------HHHHHH-HHHHHHHHHHHHH----------------------------------------------------------------------HHHHHH---HHHHH--------EEEEE----HHHHHHHHEHH-----------EEEEEE-H-----------HHHHHHHHHHHHH--
PSSM	        -----------HHHHHHHHHHHHHHHHH---------------HHHH-HHHHHHHHHHHHHHH------------------------------H--------------------------------------HHHHH---HHHHHH-------EEEEE-------EEEEEEEE-----------EEEEEEE-HHH--------HHHHHHHHHHH----
FINAL	        -----------HHHHHHHHHHHHHHHH---------------HHHHH-HHHHHHHHHHHHHHH--------------------------------------------------------------------HHHHHH---HHHHHH-------EEEEE-----EEEEEEEEEE-----------EEEEEEEHHHH--------HHHHHHHHHHHH---
167753772       -----MEYKNIFEIEFIQRTQEIVNGYQ-----------IPFENTLF-INACVGLLIIPQQSL------------------------------FNHLPTEVVS--------AD---KWGIADTDISCIKEPNKSVKN---VARHIRNAIAHDGIRFGSDNGKDITHIKITDWKDERHKTE----TFKAVIEVTKF--------KTFVWAFAQFALTQQ
206575484       -----MGNYSDFETEFVQRTLALIDQYNEMIKELGKPFREQYNYTLT-LNCLLGLIVMPKERA------------------------------LSFLPAERLT--------QQLKTSMGLQESQLP---GPEMTLRA---LILKMRNSVAHFSVQVVSVSDERL--VDLIAFRDDPEDEN----AY-ATFSAPEL--------LPFLKYYASLLLNNM
209544855       -----MGIPSDPLLDIMRRSLINLDFIEANYQDHGL-----YEVTQL-VNTFLGAFIHPFEKSAKGKEF------------------------ISYFRARPPP--------VPFAAKT-----------AEDFNYLE---FIYFVRHALAHGDLHYNANKIKQI--ESITLWNSKYGEKA----IR-ITLSIRDM--------RVLLLDFKNILEKMF
209921977       -----MGNYSDFETDFIERTLALIDQYNNMIE--GKPFPEQYNYTLT-LNCLLGLIVMPRERA------------------------------VSYLPSDRLT--------PELKAEIGLNESQLP---GEEMNLRE---LIHKMRNSVAHFCVQVESISDARL--VDQIIFKETHGAGR----AY-AIFSAPEL--------LPFLKYYAALLIANM
217979676       -----MGMPTEPLLVIMRRSMANLAFVETHAGPAGP-----YEVTQL-INTFLGALAHPFEAM------------------------------RDDLMALPLA--------DAAVLGWPTINKERPSD-REPASLGD---LIRLMRNGMAHGNLDYLSDGKGQI--HALRVWNTHPRTGAR---TWGTVVPIADV--------RRFLGLFVDLIERRH
225181269       -----MER-QVVEKDFVARTMHILENYD------GP-----YGVTLL-INCLLGLIVLPRERGFNR---------------------------VCHQEGIGFS--------DLGIDPQEICWGRIA---EQEQTASR---FLQCMRNSVAHIKIESISEQGE-I---ESLRFKDQSGFE--------VVMKIEKV--------KELATKLAQYVQ---
228923828       -NISLLWIQECFKPDNQDRKLKDVLSEFITIND-NIN--LYNNPGMLLMASYL-FFVYAKE---------------------------------KDFIGRDYS--------FADTSKFEVLECEKE---KRDSNY-----ICRRIRNALAHSRVHIGE--NGLI------TFEDFKPEGTKRLDYFKCTISYTDF--------GNFISAFYHGVKDRY
229175166       -NISLLWIQECLKPENQNKKVNELLREFLNKNE-NIN---LLNPSVLLMASYL-LFVYTKE---------------------------------KDFNDGDYS--------FVDISKFNVIASRKR---RPDGNY-----ICRRVRNALAHSRVHIDE--SLQI------TFEDSKPDGT---DYFKCVISCVDF--------GNFINNFMFTLKDSY
238916184       SENVTQNEIEKYKKQLEKSLLELREDKNAKISFK-----IGFVYLYA-MNFALRTEDDDYEELK-----------------------------YQELNVSKFK--------YQKENWIQYSQRNKT---QNCLFPRY---IVERMRNSLMHGNIEILLNNKGKI----EFIFRDKYNKRD----EV-ISIILEDL--------EEFLSQKCLYTGIPK
239908249       -------MYTHLHHDFAAKTRANLEFIEKACME-GIP--GTYNATQL-INSLLGMVVFLNEGKL-----------------------------VPAIPFSQLC--------SCEEIQVHLDDN------QDCSKADK---FIQQFRNAIAHCRFQAFG-SKDNI--QSFTMYDQRPKEPI----DWKIDITTQGI--------RDIAFRLVAYVIKNS
256367844       -----MGNYSDFETDFVQRTLALIDQYNEMIEVLGKPFREQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLPADRLT--------RQLKAEMGLHESQLP---GPEMNLRE---LIHKMRNSVAHFCVQVESASDAHL--VDWIVFRESQEDGE----VY-ASFSAPEL--------LPFLKYYATLLLDNM
270293299       -IEDVSPEKTQNQIKEINKSIRELKEDEDKIV--------GFNFMFP-VLRLLDISLRLEDDD------------------------------LKKISPLSVNIDGFTYEEDNLQKYYQNNSSTINK--RSETKYYY---ILERIRNAIAHGHITTYLDSNSNI----VYKLEDIWNNR--------TEKVEIDY--------DSMINFLEQPIFTER
283783211       RIIDYKIAIDSKKAKMIDRILKSIDELKEDSDSWIE-FRWFFKIIYI-INFSLRLEDTDLESIK-----------------------------YSVLNVDDFEYDSSQ---MALFVKKKISDGTIR---SRDEKFGNTIYILHKIRNAIAHGRIKLEVIDDKVY-----YVFEDCYYKRT----EL-IKIAVENM--------NQFINNVNALIK---
291288929       -----MGNYSDFETDFVQRTLALIDQYNEMIEELGKPFSEQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLPADRLT--------RQLKAEMGLHESQLP---GPEMNLRQ---LIHKMRNSVAHFCVQVESVSDAHL--VDWIVFRESQGDGD----VY-ASFSAPEL--------LPFLKYYATLLLDNI
313682815       -MGHYPEEKSEFIREFFKRTLHNLHIYLEDQQ--NSKFRYPYDVTQT-INSFLGLIVFLQDSDI-----------------------------VFTQELEDFVE-------AHLPIQWTCFDGNNG---LEEHNFRN---YLKRLRNAVSHRKIKSIPDQNNEI---MALEFRDGKNGG-----CFCAKLSVESV--------NLLITLLSRNILGAQ
329996741       -----MGNYSDFETDFVQRTLALIDQYNEMIEVQGKPFREQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLPADRLT--------LQLKAEMGLHESQLP---GPEMTLRT---LILKMRNSVAHFSVQVISVSDEHL--VDLIAFRDDPEDEN----AY-ATFSAPEL--------LPFLKYYAAQLLGNM
333378220       -------SIQYFDISFIERTLENLKKYEGK-----------YDFTML-LNSLLGLLVVPNEYNIAKKRRFKYPFLNEKISKFSSIKEIFKNKSYSFLDKDKKEI-------NQYKFRWLDDNKNVLT--INNITLES---FLRRIRNGIAHFGITPVKEDSLWIG-IIIRNYKNREMNME-------VYFEEDEL--------RTFALFIAEKYLETV
58383293        -----MGNYSDFETDFVQRTLALIDQYNEMIEVLGKPFREQYNYTLT-LNCLLGLIVLPKERA------------------------------LSFLLADRLT--------RQLKAEMGLHESQLP---GPEMNLRE---LIHKMRNSVAHFCVQVESASDAHL--VDWIVFRESQKDGE----VY-ASFSAPEL--------LPFLKYYATLLLDNM
78223734        -----QEYFRDFMVE-LNHAFLHLTEINQFDWHDQLDTSDNYELTRFIDQNIHPTYLRLIEAVYSPMLRI-----------------------PAYFSRLKRGKG------TEKLDVFNIVEELKT---SDLNELTVH--YRHVVRNGIAHGGIKFF---DNSI------SYKDKQRNED----VL-SDRTMVNVCDNIIDTCNAIVLAFSVFVIANQ
91203343        ------MDYKQIVRDFAQRTKILINEYKGD-----------YEVTLL-VNCCLGLLVVPKEID------------------------------FKKIPVEVIPE-------KDTLWGLSRESVSVKCK-ECSYVLRD---VIKKIRNGICHFDITSIPDENNQI---EFLVIKDRGGFE--------AKLSVAQL--------KELAISLTDHVYKP-
consensus/100%  .........p........p.........................................p...................................b...........................................h...hRpuh.H..hp........h.......hpp....................h..........hh...........
consensus/95%   .........p....p...+.b..l.................h...b..h..hl.......-...................................b.....................................h.....hh..hRNulsH..lp........l.......hpp...............b...ph..........hh..h...hb...
consensus/90%   .........p....p..p+.b..l..b..............ap..b..hs.hL.hbh..b-...................................h....................b.............p.ph.....hh..hRNuluH..lp........l.......acp...............h...ph..........hh..h...hb...
consensus/85%   ........bpp.b.cbhp+ph..lp.bp.............aphsb..hsshL.hhl..bE.................................p.h....hs..............h...p.p.......p.ph.....hhpbhRNulAH.plp.....p..l.......acpp............h.h.h.ph..........hh..h...lb...
consensus/80%   ........bpphb.chhp+sh..lpbhp.............aphob..lNshLshhl.sbE................................hp.h.s..hs..............h...p.p.......p.ph.....hlpbhRNulAH.plp....ps.pl.......ac-p..p.........h.hsh.ph..........hl..hs..lb...
consensus/75%   .....b..bpphb.-hhpRoh..lpbhp.............aphTh..lNshLshhl.sbE................................hp.h.spphs...........b.bh.h.pspb......p.sh.....hlc+hRNulAH.plph...ps.pl.......ac-p..p.......h.h.hsh.ch..........hl..hs.blb...
consensus/70%   .....b..bpphc.-hhpRol..lcbhp.............YshTh..lNshLGlhlhsbE................................hs.lsspphs.........pbb.bh.h.pspb......p.shpp...llc+hRNulAH.plphbs.ps.pl.....b.ac-p..p.......h.hshsh.cl........bshl..hs.blb.pb
    Back to Contents
    Phylogenetic tree of the sirtuins

    Eukariotic branches are colored blue, Archaeal branches are red and bacterial branches are green. Follow this link to <a hraf=sirtuin.png>download</a>

    Back to Contents

    Supplementary table S1: organism identifiers used in this work.

    Organism CodeScientific Name
    AaegAedes aegypti
    AbauAcinetobacter baumannii
    AbenArthroderma benhamiae
    AbipAsticcacaulis biprosthecum
    AbooAciduliprofundum boonei
    AcalAcinetobacter calcoaceticus
    AcapAjellomyces capsulatus
    AcarAnolis carolinensis
    AcelAcetivibrio cellulolyticus
    AcitAcidovorax citrulli
    AclaAspergillus clavatus
    AcolAnaerotruncus colihominis
    AderAjellomyces dermatitidis
    AflaAspergillus flavus
    AfumAspergillus fumigatus
    AgosAshbya gossypii
    AgypArthroderma gypseum
    AlaiAlbugo laibachii
    AlonAcetonema longum
    AmanAurantimonas manganoxydans
    AmarAcaryochloris marina
    AmaxArthrospira maxima
    AmedAmycolatopsis mediterranei
    AmirActinosynnema mirum
    AoryAspergillus oryzae
    AotaArthroderma otae
    AputAlistipes putredinis
    AqueAmphimedon queenslandica
    Asp.Actinomyces sp.
    AterAspergillus terreus
    AvenArchaeoglobus veneficus
    AvinAllochromatium vinosum
    BP0305phi8-36Bacillus phage 0305phi8-36
    BP1Roseovarius sp. 217 phage 1
    BPSP18Shigella phage SP18
    BPphiAS5Aeromonas phage phiAS5
    BPphiEF24CEnterococcus phage phiEF24C
    BadoBifidobacterium adolescentis
    BambBurkholderia ambifaria
    BbreBrevibacillus brevis
    BcelBacillus cellulosilyticus
    BcenBurkholderia cenocepacia
    BfraBacteroides fragilis
    BfucBotryotinia fuckeliana
    BglaBurkholderia gladioli
    BhyoBrachyspira hyodysenteriae
    BlatBrevibacillus laterosporus
    BmarBacteriovorax marinus
    BmarBermanella marisrubri
    BmarBlastopirellula marina
    BmurBrachyspira murdochii
    BparBordetella parapertussis
    BpseBurkholderia pseudomallei
    Bsp.Bacillus sp.
    BsubBrevundimonas subvibrioides
    BthuBacillus thuringiensis
    BuboBurkholderia ubonensis
    BvieBurkholderia vietnamiensis
    BxylBacteroides xylanisolvens
    CAccCandidatus Accumulibacter
    CKorCandidatus Koribacter
    CKueCandidatus Kuenenia
    CPorCandidatus Poribacteria
    CaciCatenulispora acidiphila
    CaspClostridium asparagiforme
    CbacClostridiales bacterium
    CbeiClostridium beijerinckii
    CbesCaldicellulosiruptor bescii
    CbolClostridium bolteae
    CconCampylobacter concisus
    CdifClostridium difficile
    CdubCandida dubliniensis
    CeutCoprococcus eutactus
    CfimCellulomonas fimi
    CflaCellulomonas flavigena
    CflaChthoniobacter flavus
    CginCapnocytophaga gingivalis
    CglaCandida glabrata
    CgleChryseobacterium gleum
    CgloChaetomium globosum
    CgraCampylobacter gracilis
    ChirClostridium hiranonis
    ChomCardiobacterium hominis
    CimmCoccidioides immitis
    CljuClostridium ljungdahlii
    ClusClavispora lusitaniae
    CmatCorynebacterium matruchotii
    CmilCordyceps militaris
    CmitCatenibacterium mitsuokai
    CochCapnocytophaga ochracea
    CowcCapsaspora owczarzaki
    CpinChitinophaga pinensis
    CposCoccidioides posadasii
    CrVBCafeteria roenbergensis virus BV-PW1
    CramClostridium ramosum
    CremCaenorhabditis remanei
    Csp.Capnocytophaga sp.
    Csp.Carnobacterium sp.
    Csp.Coprobacillus sp.
    Csp.Coprococcus sp.
    Csp.Cyanothece sp.
    CspuCapnocytophaga sputigena
    CtesComamonas testosteroni
    CvarChlorella variabilis
    CvioChromobacterium violaceum
    CyouCitrobacter youngae
    DaceDesulfobacca acetoxidans
    DaciDelftia acidovorans
    DalkDesulfatibacillum alkenivorans
    DalkDethiobacter alkaliphilus
    DbaaDesulfarculus baarsii
    DdesDeinococcus deserti
    DfasDictyostelium fasciculatum
    DforDorea formicigenerans
    DgadDysgonomonas gadei
    DgriDrosophila grimshawi
    DhanDebaryomyces hansenii
    DmagDesulfovibrio magneticus
    DmarDeinococcus maricopensis
    DmosDysgonomonas mossii
    DoleDesulfococcus oleovorans
    DproDeinococcus proteolyticus
    Dprodelta proteobacterium
    DrerDanio rerio
    Dsp.Delftia sp.
    Dsp.Dermacoccus sp.
    Dsp.Desmospora sp.
    DzeaDickeya zeae
    EaerEnhydrobacter aerosaccus
    EaerEnterobacter aerogenes
    EcorEikenella corrodens
    EdisEntamoeba dispar
    EeliEubacterium eligens
    EferEscherichia fergusonii
    EictEdwardsiella ictaluri
    EsabEubacterium saburreum
    EsirEubacterium siraeum
    Esp.Erythrobacter sp.
    Esp.Escherichia sp.
    EtarEdwardsiella tarda
    FalnFrankia alni
    FjohFlavobacterium johnsoniae
    FoxyFusarium oxysporum
    FperFusobacterium periodonticum
    FplaFerroglobus placidus
    FpraFaecalibacterium prausnitzii
    FpsyFlavobacterium psychrophilum
    Fsp.Frankia sp.
    Fsp.Fusobacterium sp.
    FsucFibrobacter succinogenes
    GbemGeobacter bemidjiensis
    GdiaGluconacetobacter diazotrophicus
    GgraGlomerella graminicola
    GhanGluconacetobacter hansenii
    GlovGeobacter lovleyi
    GmaxGlycine max
    GobsGemmata obscuriglobus
    GobsGeodermatophilus obscurus
    Gprogamma proteobacterium
    GvagGardnerella vaginalis
    HaurHerpetosiphon aurantiacus
    HbutHyperthermus butylicus
    HcheHahella chejuensis
    HfilHoldemania filiformis
    HhydHalanaerobium hydrogeniformans
    HhydHaliscomenobacter hydrossis
    HmarHaloarcula marismortui
    HochHaliangium ochraceum
    HturHaloterrigena turkmenica
    HwinHelicobacter winghamensis
    IaggIgnisphaera aggregans
    IhosIgnicoccus hospitalis
    IiV6Invertebrate iridescent virus 6
    IpolIlyobacter polytropus
    Jsp.Jannaschia sp.
    KalgKordia algicida
    KflaKribbella flavida
    KlacKluyveromyces lactis
    KoraKingella oralis
    KpasKomagataella pastoris
    KpneKlebsiella pneumoniae
    KracKtedonobacter racemifer
    KsetKitasatospora setae
    Ksp.Klebsiella sp.
    LVLausannevirus
    LaggLabrenzia aggregata
    LbacLachnospiraceae bacterium
    LbicLaccaria bicolor
    LbraLeishmania braziliensis
    LbreLactobacillus brevis
    LbucLeptotrichia buccalis
    LeloLodderomyces elongisporus
    LgooLeptotrichia goodfellowii
    LhofLeptotrichia hofstadii
    LinfLeishmania infantum
    LmacLeptosphaeria maculans
    Lsp.Lyngbya sp.
    LtheLachancea thermotolerans
    LultLactobacillus ultunensis
    MVMarseillevirus
    MacrMetarhizium acridum
    Mactmarine actinobacterium
    MadhMarinobacter adhaerens
    ManiMetarhizium anisopliae
    MaurMicromonospora aurantiaca
    MchtMicrocoleus chthonoplastes
    MconMethanosaeta concilii
    MextMethylobacterium extorquens
    MfulMyxococcus fulvus
    Mgammarine gamma
    MgloMalassezia globosa
    MguiMeyerozyma guilliermondii
    MkanMethanopyrus kandleri
    MlarMelampsora larici-populina
    MmahMethanohalophilus mahii
    MmarMicroscilla marina
    MmetMethylomonas methanica
    MmulMacaca mulatta
    MoryMagnaporthe oryzae
    MpalMucilaginibacter paludis
    MpetMethylibium petroleiphilum
    MphoMicrolunatus phosphovorus
    MrumMethanobrevibacter ruminantium
    MsilMethylocella silvestris
    Msp.Marinobacter sp.
    Msp.Micromonas sp.
    Msp.Micromonospora sp.
    Msp.Moritella sp.
    MstaMethanosphaera stadtmanae
    MtheMethanosaeta thermophila
    MtriMethylosinus trichosporium
    MtunMethylobacter tundripaludum
    MvagMicrocoleus vaginatus
    MzhiMethanosalsum zhilinae
    NabiNeodiprion abietis
    NbacNocardioidaceae bacterium
    NdasNocardiopsis dassonvillei
    NeloNeisseria elongata
    NfisNeosartorya fischeri
    NflaNeisseria flavescens
    NhaeNectria haematococca
    NhalNitrosococcus halophilus
    NmarNitrosopumilus maritimus
    NmulNakamurella multipartita
    NspuNodularia spumigena
    NsubNeisseria subflava
    NtetNeurospora tetrasperma
    NvitNasonia vitripennis
    OantOctadecabacter antarcticus
    ObatOceanicola batsensis
    OlucOstreococcus lucimarinus
    OmorOsmerus mordax
    Osp.Oribacterium sp.
    Osp.Oscillatoria sp.
    OterOpitutus terrae
    OtriOscillochloris trichoides
    PansPodospora anserina
    ParcPsychrobacter arcticus
    ParsPyrobaculum arsenaticum
    PbraParacoccidioides brasiliensis
    PbraPlanctomyces brasiliensis
    PcalPyrobaculum calidifontis
    PcapPseudoflavonifractor capillosus
    PcarPectobacterium carotovorum
    PchrPenicillium chrysogenum
    PcryPsychrobacter cryohalolentis
    PcurPaenibacillus curdlanolyticus
    PentPseudomonas entomophila
    PgraPuccinia graminis
    PislPyrobaculum islandicum
    PlavParvibaculum lavamentivorans
    PlimPlanctomyces limnophilus
    PmarPenicillium marneffei
    PmarPerkinsus marinus
    PmarPlanctomyces maris
    PmenPseudomonas mendocina
    PmirProteus mirabilis
    PoriPrevotella oris
    PpacPlesiocystis pacifica
    PpalPolysphondylium pallidum
    PparPedosphaera parvula
    PpenProteus penneri
    PpolPaenibacillus polymyxa
    PrumPrevotella ruminicola
    PrusProvidencia rustigianii
    PsitPicea sitchensis
    Psp.Paenibacillus sp.
    Psp.Psychrobacter sp.
    Psp.Pusillimonas sp.
    PsucPhascolarctobacterium succinatutens
    PsyrPseudomonas syringae
    PtimPrevotella timonensis
    PtorPsychroflexus torquis
    PtriPyrenophora tritici-repentis
    PverPrevotella veroralis
    RalbRuminococcus albus
    RbalRhodopirellula baltica
    RbroRaphidiopsis brookii
    RcasRoseiflexus castenholzii
    RdenRothia dentocariosa
    RetlRhizobium etli
    RflaRuminococcus flavefaciens
    RgnaRuminococcus gnavus
    RintRoseburia intestinalis
    RlegRhizobium leguminosarum
    RpicRalstonia pickettii
    RsliRunella slithyformis
    Rsp.Rahnella sp.
    Rsp.Roseibium sp.
    Rsp.Roseiflexus sp.
    Rsp.Roseobacter sp.
    Rsp.Ruegeria sp.
    SalbStreptomyces albus
    SareSalinispora arenicola
    SaurStigmatella aurantiaca
    SbinStreptomyces bingchenggensis
    ScarStaphylococcus carnosus
    ScelSorangium cellulosum
    SclaStreptomyces clavuligerus
    ScomSchizophyllum commune
    SdegSaccharophagus degradans
    SflaStreptomyces flavogriseus
    SfumSyntrophobacter fumaroxidans
    SghaStreptomyces ghanaensis
    SgriStreptomyces griseoaurantiacus
    SgriStreptomyces griseoflavus
    SgriStreptomyces griseus
    ShelSlackia heliotrinireducens
    ShimStreptomyces himastatinicus
    SinvSolenopsis invicta
    SjapSchistosoma japonicum
    SjapSchizosaccharomyces japonicus
    SkowSaccoglossus kowalevskii
    SkujSulfuricurvum kujiense
    SlacSerpula lacrymans
    SlinSpirosoma linguale
    SlipSyntrophothermus lipocalidus
    SlivStreptomyces lividans
    SmarStaphylothermus marinus
    SnasStackebrandtia nassauensis
    SparStreptococcus parasanguinis
    SpriStreptomyces pristinaespiralis
    SputShewanella putrefaciens
    SrosStreptomyces roseosporus
    SrosStreptosporangium roseum
    SsanStreptococcus sanguinis
    SsatShuttleworthia satelles
    SscaStreptomyces scabiei
    SsclSclerotinia sclerotiorum
    Ssp.Salpingoeca sp.
    Ssp.Sphingomonas sp.
    Ssp.Streptococcus sp.
    Ssp.Streptomyces sp.
    SstiScheffersomyces stipitis
    SsviStreptomyces sviceus
    SterSebaldella termitidis
    StroSalinispora tropica
    SvenStreptomyces venezuelae
    SvioStreptomyces violaceusniger
    SvirStreptomyces viridochromogenes
    TaquThermus aquaticus
    TbacThermotogales bacterium
    TbarThermococcus barophilus
    TbruTrypanosoma brucei
    TcasTribolium castaneum
    TcurThermomonospora curvata
    TdenThiobacillus denitrificans
    TmelTuber melanosporum
    TreeTrichoderma reesei
    TrubTrichophyton rubrum
    Tsp.Thauera sp.
    TstiTalaromyces stipitatus
    TsulThioalkalivibrio sulfidophilus
    TtheTetrahymena thermophila
    TtonTrichophyton tonsurans
    TturTeredinibacter turnerae
    TvagTrichomonas vaginalis
    TverTrichophyton verrucosum
    UDesuncultured Desulfobacterium
    Umetuncultured methanogenic
    UreeUncinocarpus reesii
    ValbVerticillium albo-atrum
    VbacVibrionales bacterium
    VdisVulcanisaeta distributa
    VharVibrio harveyi
    VmarVerrucosispora maris
    VparVariovorax paradoxus
    VpolVanderwaltozyma polyspora
    VspiVerrucomicrobium spinosum
    VsplVibrio splendidus
    X(SiXenopus (Silurana)
    XfusXanthomonas fuscans
    XnemXenorhabdus nematophila
    XperXanthomonas perforans
    XvesXanthomonas vesicatoria
    YlipYarrowia lipolytica
    ZmobZymomonas mobilis
    ZrouZygosaccharomyces rouxii

    Back to Contents

    Supplementary table S2: sequence accession numbers.

    giaccessionidentifier
    153817467ZP_01970134A5C_A0388_Vcho_153817467
    169634335YP_001708071ABSDF2913_Abau_169634335
    184156423YP_001844762ACICU_00103_Abau_184156423
    158335874YP_001517048AM1_2731_Amar_158335874
    158336844YP_001518018AM1_3712_Amar_158336844
    300783556YP_003763847AMED_1633_Amed_300783556
    167769817ZP_02441870ANACOL_01151_Acol_167769817
    303238852ZP_07325383AceceDRAFT_0731_Acel_303238852
    303240378ZP_07326896AceceDRAFT_2244_Acel_303240378
    256377585YP_003101245Amir_3505_Amir_256377585
    226314127YP_002774023BBR47_45420_Bbre_226314127
    30022569NP_834200BC4488_Bcer_30022569
    206563730YP_002234493BCAM1881_Bcen_206563730
    225619532YP_002720789BHWA1_00589_Bhyo_225619532
    301167374CBW26956BMS_2150_Bmar_301167374
    295087466CBK68989BXY_40670_Bxyl_295087466
    134288349YP_001110512Bcep1808_6822_Bvie_134288349
    255010211ZP_05282337Bfra3_010100013815_Bfra_255010211
    296125416YP_003632668Bmur_0365_Bmur_296125416
    302383816YP_003819639Bresu_2709_Bsub_302383816
    212646224NP_507592C08E8.4_Cele_212646224
    257460202ZP_05625306CAMGR0001_0616_Cgra_257460202
    257093308YP_003166949CAP2UW1_1710_CAcc_257093308
    239627871ZP_04670902CBFG_01593_Cbac_239627871
    157165319YP_001467147CCC13826_2022_Ccon_157165319
    295094771CBK83862CCU_25310_Csp._295094771
    283836396ZP_06356137CIT292_10857_Cyou_283836396
    225020576ZP_03709768CORMATOL_00583_Cmat_225020576
    110802054YP_697488CPR_0151_Cper_110802054
    282897552ZP_06305552CRD_01664_Rbro_282897552
    256392113YP_003113677Caci_2927_Caci_256392113
    256393748YP_003115312Caci_4610_Caci_256393748
    256395008YP_003116572Caci_5873_Caci_256395008
    150018370YP_001310624Cbei_3546_Cbei_150018370
    256419128YP_003119781Cpin_0074_Cpin_256419128
    220905714YP_002481025Cyan7425_0270_Csp._220905714
    307153746YP_003889130Cyan7822_3925_Csp._307153746
    66812724XP_640541DDB_G0281625_Ddis_66812724
    66810169XP_638808DDB_G0283925_Ddis_66810169
    330798615XP_003287347DICPUDRAFT_22458_Dpur_330798615
    330802814XP_003289408DICPUDRAFT_35661_Dpur_330802814
    330843562XP_003293720DICPUDRAFT_42446_Dpur_330843562
    330846708XP_003295151DICPUDRAFT_85573_Dpur_330846708
    166032191ZP_02235020DORFOR_01894_Dfor_166032191
    15806282NP_294987DR_1263_Drad_15806282
    160901192YP_001566774Daci_5761_Daci_160901192
    320334379YP_004171090Deima_1776_Dmar_320334379
    325284428YP_004256968Deipr_2488_Dpro_325284428
    149186578ZP_01864890ED21_31874_Esp._149186578
    158079465YP_001504278EFP_gp169_BPphiEF24C_158079465
    67472915XP_652245EHI_017590_Ehis_67472915
    170684265YP_001745340EcSMS35_3361_Ecol_170684265
    298707265CBJ25892Esi_0017_0056_Esil_298707265
    298714411CBJ27468Esi_0071_0113_Esil_298714411
    298711392CBJ32535Esi_0345_0025_Esil_298711392
    32565136NP_498956F44E2.8_Cele_32565136
    46111757XP_382936FG02760.1_Gzea_46111757
    150026339YP_001297165FP2309_Fpsy_150026339
    295103146CBL00690FPR_02440_Fpra_295103146
    111221771YP_712565FRAAL2340_Faln_111221771
    237744336ZP_04574817FSDG_00336_Fsp._237744336
    261415758YP_003249441Fisuc_1361_Fsuc_261415758
    146298513YP_001193104Fjoh_0750_Fjoh_146298513
    288920206ZP_06414521FrEUN1fDRAFT_4219_Fsp._288920206
    312200713YP_004020774FraEuI1c_6936_Fsp._312200713
    237813318YP_002897769GBP346_A3087_Bpse_237813318
    291459520ZP_06598910GCWU000341_01684_Osp._291459520
    229828516ZP_04454585GCWU000342_00580_Ssat_229828516
    119476904ZP_01617185GP2143_10137_Mgam_119476904
    254482777ZP_05096014GPB2148_1261_Mgam_254482777
    296414614XP_002836993GSTUM_00003347001_Tmel_296414614
    296424705XP_002841887GSTUM_00011304001_Tmel_296424705
    261410041YP_003246282GYMC10_6272_Psp._261410041
    197117872YP_002138299Gbem_1485_Gbem_197117872
    189425639YP_001952816Glov_2583_Glov_189425639
    168698168ZP_02730445GobsU_010100001512_Gobs_168698168
    168699662ZP_02731939GobsU_010100009074_Gobs_168699662
    168700969ZP_02733246GobsU_010100015693_Gobs_168700969
    168704676ZP_02736953GobsU_010100034385_Gobs_168704676
    154278399XP_001540013HCAG_05480_Acap_154278399
    83646809YP_435244HCH_04109_Hche_83646809
    83647036YP_435471HCH_04340_Hche_83647036
    83649602YP_438037HCH_06997_Hche_83649602
    262281016ZP_06058799HMPREF0012_02967_Acal_262281016
    258545510ZP_05705744HMPREF0198_1779_Chom_258545510
    300774513ZP_07084376HMPREF0204_10236_Cgle_300774513
    299141967ZP_07035101HMPREF0665_01551_Pori_299141967
    315224011ZP_07865852HMPREF1977_0666_Coch_315224011
    326335654ZP_08201841HMPREF9071_1307_Csp._326335654
    325690155EGD32159HMPREF9382_1113_Ssan_325690155
    325694076EGD35994HMPREF9383_1770_Ssan_325694076
    319937960ZP_08012360HMPREF9488_03196_Csp._319937960
    223985602ZP_03635653HOLDEFILI_02959_Hfil_223985602
    311695670ADP98543HP15_2779_Madh_311695670
    237752248ZP_04582728HWAG_01373_Hwin_237752248
    159896886YP_001543133Haur_0354_Haur_159896886
    15078868NP_149618IIV6gp151_IiV6_15078868
    310778851YP_003967184Ilyop_1055_Ipol_310778851
    89055288YP_510739Jann_2797_Jsp._89055288
    163754439ZP_02161561KAOT1_16128_Kalg_163754439
    311894452BAJ26860KSE_10250_Kset_311894452
    311895942BAJ28350KSE_25370_Kset_311895942
    284029681YP_003379612Kfla_1718_Kfla_284029681
    48696395YP_024435KgORF4_BPK_48696395
    119486659ZP_01620709L8106_12950_Lsp._119486659
    170107053XP_001884737LACBIDRAFT_252516_Lbic_170107053
    170117768XP_001890069LACBIDRAFT_316770_Lbic_170117768
    170095960XP_001879200LACBIDRAFT_318005_Lbic_170095960
    327409634YP_004347054LAU_0089_LV_327409634
    217965001YP_002350679LMHCC_1724_Lmon_217965001
    217965272YP_002350950LMHCC_1997_Lmon_217965272
    72168255XP_793312LOC588539_Spur_72168255
    154331017XP_001561948LbrM06_V2.0110_Lbra_154331017
    146070759XP_001463095LINJ_06_0130_Linf_146070759
    124010457ZP_01695096M23134_00353_Mmar_124010457
    124004845ZP_01689688M23134_02260_Mmar_124004845
    124004851ZP_01689694M23134_02266_Mmar_124004851
    124009340ZP_01694019M23134_07250_Mmar_124009340
    284504143YP_003406858MAR_ORF111_MV_284504143
    254412559ZP_05026333MC7420_6514_Mcht_254412559
    254413191ZP_05026962MC7420_678_Mcht_254413191
    238062132ZP_04606841MCAG_03098_Msp._238062132
    330502141YP_004379010MDS_1227_Pmen_330502141
    164657874XP_001730063MGL_3049_Mglo_164657874
    315054313XP_003176531MGYG_00619_Agyp_315054313
    108762267YP_633480MXAN_5330_Mxan_108762267
    240141986YP_002966496MexAM1_META2p0262_Mext_240141986
    302868047YP_003836684Micau_3582_Maur_302868047
    117924481YP_865098Mmc1_1181_Masp_117924481
    124262828YP_001023298Mpe_B0288_Mpet_124262828
    84489297YP_447529Msp_0486_Msta_84489297
    119509756ZP_01628901N9414_00365_Nspu_119509756
    290996214XP_002680677NAEGRDRAFT_31151_Ngru_290996214
    290996009XP_002680575NAEGRDRAFT_31328_Ngru_290996009
    290990814XP_002678031NAEGRDRAFT_36485_Ngru_290990814
    290997341XP_002681240NAEGRDRAFT_46602_Ngru_290997341
    326330475ZP_08196783NBCG_01909_Nbac_326330475
    302884348XP_003041070NECHADRAFT_29138_Nhae_302884348
    261381097ZP_05985670NEISUBOT_05210_Nsub_261381097
    301059840ZP_07200732NPH_6632_Dpro_301059840
    258651665YP_003200821Namu_1431_Nmul_258651665
    297563442YP_003682416Ndas_4523_Ndas_297563442
    254453984ZP_05067421OA238_4610_Oant_254453984
    156564215YP_001429725ORF234_BP0305phi8-36_156564215
    300866977ZP_07111648OSCI_3190004_Osp._300866977
    309791192ZP_07685724OSCT_1675_Otri_309791192
    145348536XP_001418703OSTLU_35648_Oluc_145348536
    149908726ZP_01897387PE36_21039_Msp._149908726
    70733106YP_262879PFL_5821_Pflu_70733106
    149175186ZP_01853808PM8797T_20343_Pmar_149175186
    149176205ZP_01854821PM8797T_29763_Pmar_149176205
    212541268XP_002150789PMAA_059590_Pmar_212541268
    308069201YP_003870806PPE_02438_Ppol_308069201
    281209628EFA83796PPL_02864_Ppal_281209628
    226326967ZP_03802485PROPEN_00827_Ppen_226326967
    294673111YP_003573727PRU_0345_Prum_294673111
    294673143YP_003573759PRU_0382_Prum_294673143
    152987782YP_001348410PSPA7_3050_Paer_152987782
    152985284YP_001350552PSPA7_5219_Paer_152985284
    330874307EGH08456PSYMP_06728_Psyr_330874307
    332285914YP_004417825PT7_2661_Psp._332285914
    189204778XP_001938724PTRG_08392_Ptri_189204778
    326434983EGD80553PTSG_01145_Ssp._326434983
    304407843ZP_07389494PaecuDRAFT_4172_Pcur_304407843
    255940726XP_002561132Pc16g08100_Pchr_255940726
    93005719YP_580156Pcryo_0891_Pcry_93005719
    325107565YP_004268633Plabr_0990_Pbra_325107565
    296122446YP_003630224Plim_2199_Plim_296122446
    294875527XP_002767363Pmar_PMAR024558_Pmar_294875527
    148652988YP_001280081PsycPRwf_1182_Psp._148652988
    71064897YP_263624Psyc_0321_Parc_71064897
    71065404YP_264131Psyc_0844_Parc_71065404
    311978014YP_003987134R617_APMV_311978014
    94501287ZP_01307808RED65_02704_Bmar_94501287
    291535823CBL08935ROI_18700_Rint_291535823
    240146453ZP_04745054ROSINTL182_08410_Rint_240146453
    240147581ZP_04746182ROSINTL182_09631_Rint_240147581
    154503599ZP_02040659RUMGNA_01423_Rgna_154503599
    268609453ZP_06143180RflaF_010100008155_Rfla_268609453
    241589866YP_002979891Rpic12D_5003_Rpic_241589866
    317056301YP_004104768Rumal_1634_Ralb_317056301
    259416444ZP_05740364SCH4B_1850_Sisp_259416444
    302674848XP_003027108SCHCODRAFT_258659_Scom_302674848
    302674850XP_003027109SCHCODRAFT_258660_Scom_302674850
    302693411XP_003036384SCHCODRAFT_36431_Scom_302693411
    302783817XP_002973681SELMODRAFT_413953_Smoe_302783817
    329936685ZP_08286392SGM_1884_Sgri_329936685
    156053544XP_001592698SS1G_05618_Sscl_156053544
    125718681YP_001035814SSA_1883_Ssan_125718681
    291448123ZP_06587513SSGG_05341_Sros_291448123
    302558106ZP_07310448SSRG_01621_Sgri_302558106
    170078553YP_001735191SYNPCC7002_A1948_Syn_170078553
    224477787YP_002635393Sca_2305_Scar_224477787
    90020054YP_525881Sde_0405_Sdeg_90020054
    284036735YP_003386665Slin_1821_Slin_284036735
    239939813ZP_04691750SrosN15_010100002350_Sros_239939813
    271963927YP_003338123Sros_2401_Sros_271963927
    269121732YP_003309909Sterm_3136_Ster_269121732
    17564644NP_503984T24A6.7_Cele_17564644
    254787804YP_003075233TERTU_3943_Ttur_254787804
    99081738YP_613892TM1040_1897_Rsp._99081738
    242799239XP_002483337TSTA_012120_Tsti_242799239
    118370894XP_001018647TTHERM_00289300_Tthe_118370894
    118401008XP_001032825TTHERM_00486130_Tthe_118401008
    118397133XP_001030901TTHERM_00998900_Tthe_118397133
    123462122XP_001316875TVAG_227690_Tvag_123462122
    72391614XP_846101Tb927.7.4780_Tbru_72391614
    71654521XP_815878Tc00.1047053507521.60_Tcru_71654521
    269124625YP_003297995Tcur_0355_Tcur_269124625
    113476072YP_722133Tery_2448_Tery_113476072
    220934941YP_002513840Tgr7_1771_Tsul_220934941
    84392320ZP_00991747V12B01_14190_Vspl_84392320
    330468357YP_004406100VAB18032_22000_Vmar_330468357
    269960099ZP_06174476VME_08600_Vhar_269960099
    28899861NP_799516VPA0006_Vpar_28899861
    148975384ZP_01812308VSWAT3_18363_Vbac_148975384
    171913880ZP_02929350VspiD_010100021915_Vspi_171913880
    294664143ZP_06729532XAUC_02590_Xfus_294664143
    300723771YP_003713078XNC1_2895_Xnem_300723771
    824079902b3wA_Ecol_82407990
    308516893CBW46998_BP1_308516893
    154487137ZP_02028544_Bado_154487137
    33601359NP_888919_Bbro_33601359
    33595978NP_883621_Bpar_33595978
    221067792ZP_03543897_Ctes_221067792
    160945657ZP_02092883_Fpra_160945657
    160945914ZP_02093140_Fpra_160945914
    238022350ZP_04602776_Kora_238022350
    298249651ZP_06973455_Krac_298249651
    298250178ZP_06973982_Krac_298250178
    32471506NP_864499_Rbal_32471506
    17232521NP_489069all5029_Ana_17232521
    229129773ZP_04258740bcere0015_42140_Bcer_229129773
    330822167YP_004350995bgla_2p0770_Bgla_330822167
    330818849YP_004351066bgla_3p0420_Bgla_330818849
    330814539YP_004362714bgla_4p0890_Bgla_330814539
    228982721ZP_04142980bthur0002_58540_Bthu_228982721
    308814565YP_003934839gp30.3_BPSP18_308814565
    288561223YP_003424709mru_1967_Mrum_288561223
    325680741ZP_08160279nadE_Ralb_325680741
    60461911YP_209629pIL105p2_Llac_60461911
    310722519YP_003969342phiAS5_ORF0053_BPphiAS5_310722519
    162451636YP_001614003sce3364_Scel_162451636
    22300007NP_683254tlr2465_Telo_22300007
    300869472ZP_07114055ybiA_Osp._300869472
    311112847YP_003984069ybiA_Rden_311112847
    296876279ZP_06900331ybiA_Spar_296876279
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    291237935XP_002738885LOC100367844_Skow_291237935
    291288929YP_003517432pKF94_017_Kpne_291288929
    291300690YP_003511968Snas_3205_Snas_291300690
    291301515YP_003512793Snas_4048_Snas_291301515
    291438820ZP_06578210SSFG_03915_Sgha_291438820
    291444753ZP_06584143SSGG_01970_Sros_291444753
    291453417ZP_06592807SSHG_03710_Salb_291453417
    292493384YP_003528823Nhal_3405_Nhal_292493384
    294494713YP_003541206Mmah_0023_Mmah_294494713
    294628199ZP_06706759SSTG_00199_Ssp._294628199
    294657248XP_459547DEHA2E05236g_Dhan_294657248
    294664142ZP_06729531XAUC_02580_Xfus_294664142
    294669065ZP_06734151NEIELOOT_00979_Nelo_294669065
    294781860ZP_06747192HMPREF0400_02088_Fsp._294781860
    294817221ZP_06775863SCLAV_p0684_Scla_294817221
    295087467CBK68990BXY_40680_Bxyl_295087467
    295093305CBK82396CCU_05780_Csp._295093305
    295658070XP_002789598PAAG_08523_Pbra_295658070
    295839520ZP_06826453SSBG_06269_Ssp._295839520
    296114887ZP_06833535GXY_03898_Ghan_296114887
    296121824YP_003629602Plim_1570_Plim_296121824
    296130288YP_003637538Cfla_2451_Cfla_296130288
    296130683YP_003637933Cfla_2850_Cfla_296130683
    296416279XP_002837808GSTUM_00005659001_Tmel_296416279
    296446434ZP_06888378MettrDRAFT_2094_Mtri_296446434
    296821722XP_002850170MCYG_00274_Aota_296821722
    296825168XP_002850772MCYG_00876_Aota_296825168
    297162424ADI12136SBI_09018_Sbin_297162424
    297192271ZP_06909669SSDG_01873_Spri_297192271
    297194315ZP_06911713SSDG_06844_Spri_297194315
    297202026ZP_06919423SSEG_09591_Ssvi_297202026
    297202028ZP_06919425SSEG_04858_Ssvi_297202028
    297204161ZP_06921558SSEG_04772_Ssvi_297204161
    297267544XP_001115358LOC717911_Mmul_297267544
    297561069YP_003680043Ndas_2112_Ndas_297561069
    297561422YP_003680396Ndas_2470_Ndas_297561422
    297564265YP_003683238Ndas_5352_Ndas_297564265
    297618118YP_003703277Slip_1960_Slip_297618118
    298245737ZP_06969543_Krac_298245737
    298246337ZP_06970143_Krac_298246337
    298248426ZP_06972231_Krac_298248426
    298250918ZP_06974722_Krac_298250918
    29826642NP_821276SAV_102_Save_29826642
    29829850NP_824484SAV_3308_Save_29829850
    29830778NP_825412SAV_4235_Save_29830778
    298711928CBJ48615Esi_0039_0083_Esil_298711928
    299141966ZP_07035100HMPREF0665_01550_Pori_299141966
    299472429CBN77617Esi_0004_0276_Esil_299472429
    299472531CBN77316Esi_0044_0118_Esil_299472531
    30022567NP_834198BC4486_Bcer_30022567
    300774500ZP_07084363kptA_Cgle_300774500
    300774505ZP_07084368HMPREF0204_10228_Cgle_300774505
    300774507ZP_07084370HMPREF0204_10230_Cgle_300774507
    300784169YP_003764460kptA_Amed_300784169
    300789763YP_003770054AMED_7947_Amed_300789763
    300854685YP_003779669CLJU_c15030_Clju_300854685
    300867123ZP_07111789OSCI_3240019_Osp._300867123
    300868768ZP_07113379OSCI_3800101_Osp._300868768
    300868996ZP_07113599kptA_Osp._300868996
    300869632ZP_07114212OSCI_4130042_Osp._300869632
    301058276ZP_07199316NPH_6498_Dpro_301058276
    302344076YP_003808605Deba_2657_Dbaa_302344076
    302411952XP_003003809VDBG_06251_Valb_302411952
    30249340NP_841410NE1363_Neur_30249340
    302504024XP_003013971ARB_07691_Aben_302504024
    302525419ZP_07277761SSMG_01801_Ssp._302525419
    302526847ZP_07279189SSMG_03229_Ssp._302526847
    302529076ZP_07281418SSMG_05458_Ssp._302529076
    302535927ZP_07288269SSNG_03890_Ssp._302535927
    302548144ZP_07300486SSOG_08569_Shim_302548144
    302549980ZP_07302322SSQG_01209_Svir_302549980
    302553253ZP_07305595SSQG_04482_Svir_302553253
    302657470XP_003020456TRV_05457_Tver_302657470
    302686072XP_003032716SCHCODRAFT_40957_Scom_302686072
    302756333XP_002961590SELMODRAFT_35951_Smoe_302756333
    302757341XP_002962094SELMODRAFT_77175_Smoe_302757341
    302766619XP_002966730SELMODRAFT_85925_Smoe_302766619
    302782377XP_002972962SELMODRAFT_98231_Smoe_302782377
    302796097XP_002979811SELMODRAFT_111206_Smoe_302796097
    302851356XP_002957202VOLCADRAFT_119630_Vcar_302851356
    302864537YP_003833174Micau_0029_Maur_302864537
    302866493YP_003835130Micau_2007_Maur_302866493
    302867267YP_003835904Micau_2794_Maur_302867267
    302868056YP_003836693Micau_3591_Maur_302868056
    302869104YP_003837741Micau_4654_Maur_302869104
    302916847XP_003052234NECHADRAFT_79207_Nhae_302916847
    302922871XP_003053556NECHADRAFT_74824_Nhae_302922871
    303240380ZP_07326898AceceDRAFT_2246_Acel_303240380
    303240837ZP_07327349AceceDRAFT_2697_Acel_303240837
    303241812ZP_07328308AceceDRAFT_3656_Acel_303241812
    303284891XP_003061736MICPUCDRAFT_48280_Mpus_303284891
    303312351XP_003066187CPC735_054120_Cpos_303312351
    304309800YP_003809398HDN1F_01480_Gpro_304309800
    304405428ZP_07387087PaecuDRAFT_1748_Pcur_304405428
    304560215ADM42879ETAF_2777_Etar_304560215
    305663054YP_003859342Igag_0628_Iagg_305663054
    307104106EFN52361CHLNCDRAFT_138778_Cvar_307104106
    307105263EFN53513CHLNCDRAFT_59736_Cvar_307105263
    307150228YP_003885612Cyan7822_0291_Csp._307150228
    307154521YP_003889905Cyan7822_4726_Csp._307154521
    307299774ZP_07579566ThebaDRAFT_2537_Tbac_307299774
    307595891YP_003902208Vdis_1783_Vdis_307595891
    307823107ZP_07653337MettuDRAFT_1182_Mtun_307823107
    307823108ZP_07653338MettuDRAFT_1183_Mtun_307823108
    307946056ZP_07661391TRICHSKD4_4759_Rsp._307946056
    308270161CBX26773N47_A08020_UDes_308270161
    308446799XP_003087265CRE_02794_Crem_308446799
    309811906ZP_07705678HMPREF0321_1867_Dsp._309811906
    310641074YP_003945832PPSC2_c1614_Ppol_310641074
    310778852YP_003967185Ilyop_1056_Ipol_310778852
    310792989EFQ28450GLRG_03594_Ggra_310792989
    310796940EFQ32401GLRG_07671_Ggra_310796940
    310818319YP_003950677STAUR_1046_Saur_310818319
    310818708YP_003951066STAUR_1435_Saur_310818708
    310831101YP_003969744crov112_CrVB_310831101
    311896751BAJ29159KSE_33500_Kset_311896751
    311899069BAJ31477kptA_Kset_311899069
    311900362BAJ32770KSE_70120_Kset_311900362
    312142649YP_003994095Halsa_0262_Hhyd_312142649
    312199543YP_004019604FraEuI1c_5750_Fsp._312199543
    312220715CBY00656LEMA_P017860.1_Lmac_312220715
    312886331ZP_07745943MucpaDRAFT_5912_Mpal_312886331
    312888255ZP_07747832MucpaDRAFT_5105_Mpal_312888255
    312888451ZP_07748025MucpaDRAFT_5539_Mpal_312888451
    313682815YP_004060553Sulku_1692_Skuj_313682815
    315054759XP_003176754MGYG_00842_Agyp_315054759
    315230724YP_004071160TERMP_00961_Tbar_315230724
    315502903YP_004081790ML5_2113_Msp._315502903
    315504426YP_004083313ML5_3650_Msp._315504426
    315506327YP_004085214ML5_5602_Msp._315506327
    315652379ZP_07905368HMPREF0381_2362_Esab_315652379
    317056274YP_004104741Rumal_1607_Ralb_317056274
    317126949YP_004093231Bcell_0212_Bcel_317126949
    318058555ZP_07977278SSA3_010100011465_Ssp._318058555
    319936601ZP_08011014HMPREF9488_01847_Csp._319936601
    320010749ADW05599Sfla_4190_Sfla_320010749
    320095331ZP_08027020HMPREF9005_1632_Asp._320095331
    320168635EFW45534CAOG_03518_Cowc_320168635
    320333489YP_004170200Deima_0881_Dmar_320333489
    320333790YP_004170501Deima_1184_Dmar_320333790
    322505025CAM42259LBRM_24_0830_Lbra_322505025
    322699163EFY90927MAC_03043_Macr_322699163
    322707126EFY98705MAA_05844_Mani_322707126
    322708785EFZ00362MAA_04139_Mani_322708785
    322802863EFZ23054SINV_01220_Sinv_322802863
    322815443EFZ24097TCSYLVIO_9776_Tcru_322815443
    322832748YP_004212775Rahaq_2033_Rsp._322832748
    323140426ZP_08075355HMPREF9443_00109_Psuc_323140426
    32476856NP_869850_Rbal_32476856
    325108247YP_004269315Plabr_1682_Pbra_325108247
    325189229CCA23752AlNc14C205G8800_Alai_325189229
    325283812YP_004256353Deipr_1598_Dpro_325283812
    325690156EGD32160HMPREF9382_1114_Ssan_325690156
    325917965ZP_08180134XVE_4155_Xves_325917965
    325928686ZP_08189859XPE_3947_Xper_325928686
    326431934EGD77504PTSG_08602_Ssp._326431934
    326470706EGD94715TESG_02225_Tton_326470706
    326779281ZP_08238546SACT1_5140_Sgri_326779281
    326943719AEA19612CT43_P281274_Bthu_326943719
    327286590XP_003228013LOC100564547_Acar_327286590
    327308048XP_003238715TERG_00702_Trub_327308048
    327352957EGE81814BDDG_04757_Ader_327352957
    327400244YP_004341083Arcve_0335_Aven_327400244
    328769603EGF79646BATDEDRAFT_4585_Bden_328769603
    328862875EGG11975MELLADRAFT_101818_Mlar_328862875
    328866607EGG14990DFA_09810_Dfas_328866607
    328867666EGG16048DFA_09720_Dfas_328867666
    328871094EGG19465DFA_00042_Dfas_328871094
    328884339CCA57578SVEN_4292_Sven_328884339
    328886920CCA60159SVEN_6873_Sven_328886920
    328952864YP_004370198Desac_1154_Dace_328952864
    328958126YP_004375512CAR_c18390_Csp._328958126
    329184512AEB80270Dalk_0002_AVC_Dalk_329184512
    329847506ZP_08262534ABI_05710_Abip_329847506
    329935140ZP_08285131SGM_6648_Sgri_329935140
    329935335ZP_08285301SGM_6818_Sgri_329935335
    329996741ZP_08302538HMPREF9538_00174_Ksp._329996741
    330467180YP_004404923VAB18032_16085_Vmar_330467180
    330469061YP_004406804VAB18032_25530_Vmar_330469061
    330469448YP_004407191VAB18032_27591_Vmar_330469448
    330508961YP_004385389MCON_3311_Mcon_330508961
    330795375XP_003285749DICPUDRAFT_46322_Dpur_330795375
    330801102XP_003288569DICPUDRAFT_34288_Dpur_330801102
    330977809EGH77712PSYAP_13685_Psyr_330977809
    330983843EGH81946PLA107_02335_Psyr_330983843
    331216956XP_003321157PGTG_02199_Pgra_331216956
    332361966EGJ39768kptA_Ssan_332361966
    332668288YP_004451076Halhy_6384_Hhyd_332668288
    332671633YP_004454641Celf_3140_Cfim_332671633
    333027909ZP_08455973STTU_5412_Ssp._333027909
    333374005ZP_08465898HMPREF9374_3644_Dsp._333374005
    333378220ZP_08469951HMPREF9456_01546_Dmos_333378220
    333381571ZP_08473251HMPREF9455_01417_Dgad_333381571
    333912499YP_004486231DelCs14_0840_Dsp._333912499
    333985238YP_004514448Metme_3585_Mmet_333985238
    334120906ZP_08494983MicvaDRAFT_0510_Mvag_334120906
    334135982ZP_08509461HMPREF9413_4358_Psp._334135982
    336117044YP_004571811MLP_13940_Mpho_336117044
    336250841YP_004594551EAE_21855_Eaer_336250841
    336366767EGN95113SERLA73DRAFT_143184_Slac_336366767
    336428119ZP_08608104HMPREF0994_04110_Lbac_336428119
    336471510EGO59671NEUTE1DRAFT_109155_Ntet_336471510
    336475983YP_004615124Mzhil_0024_Mzhi_336475983
    338211687YP_004655740Runsl_2196_Rsli_338211687
    338532263YP_004665597LILAB_13060_Mful_338532263
    338811714ZP_08623919ALO_06468_Alon_338811714
    339009751ZP_08642322BRLA_c35710_Blat_339009751
    340377247XP_003387141LOC100640582_Aque_340377247
    340521231EGR51466TRIREDRAFT_75394_Tree_340521231
    340754465ZP_08691218FSAG_02029_Fsp._340754465
    342875667EGU77385FOXB_12108_Foxy_342875667
    34497880NP_902095CV_2425_Cvio_34497880
    344999740YP_004802594SACTE_2158_Ssp._344999740
    345013407YP_004815761Strvi_5976_Svio_345013407
    345368115EGX00122ECSTECMHI813_4950_Ecol_345368115
    346318305EGX87909CCM_09532_Cmil_346318305
    38505777NP_942396sll8002_Ssp_38505777
    45198857NP_985886AGOS_AFR339W_Agos_45198857
    46309426YP_006316ORF28_AsGV_46309426
    49477941YP_037101kptA_Bthu_49477941
    50290283XP_447573CAGL0I07469g_Cgla_50290283
    50305581XP_452751KLLA0C12397g_Klac_50305581
    50547707XP_501323YALI0C01287g_Ylip_50547707
    53718401YP_107387BPSL0762_Bpse_53718401
    55379941YP_137791kptA_Hmar_55379941
    58383293YP_194865pU302L_059_Sent_58383293
    60461910YP_209628pIL105p1_Llac_60461910
    66358336XP_626346cgd2_1210_Cpar_66358336
    66802638XP_635191DDB_G0291408_Ddis_66802638
    66807493XP_637469DDB_G0286929_Ddis_66807493
    66813652XP_641005DDB_G0280835_Ddis_66813652
    67921554ZP_00515072CwatDRAFT_5127_Cwat_67921554
    70733133YP_262906PFL_5848_Pflu_70733133
    70988759XP_749234AFUA_2G00980_Afum_70988759
    71064898YP_263625Psyc_0322_Parc_71064898
    72006229XP_780840LOC575340_Spur_72006229
    72010085XP_786744LOC581663_Spur_72010085
    74317508YP_315248Tbd_1490_Tden_74317508
    78223734YP_385481Gmet_2535_Gmet_78223734
    83643039YP_431474HCH_00129_Hche_83643039
    83647694YP_436129HCH_05019_Hche_83647694
    83649603YP_438038HCH_06998_Hche_83649603
    84392321ZP_00991748V12B01_14195_Vspl_84392321
    84499284ZP_00997572OB2597_05135_Obat_84499284
    84499293ZP_00997581OB2597_05180_Obat_84499293
    84501233ZP_00999438OB2597_12748_Obat_84501233
    85068247XP_962139NCU07285_Ncra_85068247
    85109317XP_962858NCU06254_Ncra_85109317
    87310926ZP_01093052DSM3645_18471_Bmar_87310926
    87311897ZP_01094009DSM3645_04855_Bmar_87311897
    88856595ZP_01131252A20C1_02579_Mact_88856595
    90419305ZP_01227215SI859A1_01336_Aman_90419305
    91080221XP_972212LOC660925_Tcas_91080221
    91203343CAJ72982kustd2237_CKue_91203343
    91215317ZP_01252289P700755_13507_Ptor_91215317
    94971452YP_593500Acid345_4426_CKor_94971452

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