HOP screen replicate Gene > Systematic Name Gene > Standard Name Gene > Phenotypes > Experiment Type Gene > Phenotypes > Observable Gene > Phenotypes > Qualifier Gene > Phenotypes > Chemical Gene > Phenotypes > Condition Gene > Phenotypes > Details Gene > Phenotypes > Reporter 1 YBL051C PIN4 systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 1 YBR194W AIM4 large-scale survey Mitochondrial genome maintenance abnormal decreased frequency of spontaneous mitochondrial genome loss 1 YBR194W AIM4 systematic mutation set Bud morphology abnormal bud is abnormally elongated 1 YBR231C SWC5 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;increased frequency of mitotic chromosome loss 1 YBR231C SWC5 systematic mutation set Bud morphology abnormal bud is abnormally elongated 1 YBR255W MTC4 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YCL011C GBP2 classical genetics Protein/peptide distribution abnormal foci located in the interior of the nucleus rather than correctly positioned at the periphery GFP-Rap1 1 YCL061C MRC1 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 1 YCL061C MRC1 homozygous diploid Chromosome/plasmid maintenance abnormal increased frequency of mitotic chromosome loss;diploid bimater (BiM) assay 1 YCL061C MRC1 homozygous diploid Chromosome/plasmid maintenance abnormal indicative of chromosome instability (CIN); high confidence set; 4-fold increase over wildtype;diploid bimater (BiM) assay 1 YCR034W FEN1 "homozygous diploid, systematic mutation set" Budding pattern abnormal 23% of cells exhibit unipolar budding pattern; 7% of cells exhibit random budding pattern 1 YCR034W FEN1 systematic mutation set Bud morphology abnormal bud is abnormally elongated 1 YCR088W ABP1 classical genetics Actin cytoskeleton morphology abnormal "prolongs the duration of phase I of actin cortical patch movement, increasing the median lifetime of patches at their origin; however, the final extent of patch movement is greatly increased" 1 YCR088W ABP1 classical genetics Protein/peptide distribution abnormal loss of actin cortical patch localization Srv2p 1 YEL048C TCA17 classical genetics Protein/peptide distribution abnormal decreased polar localization accompanied by increased internal localization Snc1p-GFP 1 YEL048C TCA17 classical genetics Protein/peptide distribution abnormal punctate localization pattern is lost and localization appears diffuse GFP-Ypt31p 1 YEL048C TCA17 classical genetics Protein/peptide distribution abnormal small decrease in amount of Bet5p in the TRAPP II complex Bet5p-13Myc 1 YEL053C MAK10 classical genetics Protein/peptide distribution abnormal Imh1p-GFP (exhibits diffuse cytoplamic pattern rather than Golgi localization) 1 YEL053C MAK10 classical genetics Protein/peptide distribution abnormal Trm1p-II-GFP (Trm1p is localized to the nucleoplasm instead of to the inner nuclear membrane) 1 YEL053C MAK10 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YEL060C PRB1 systematic mutation set Chemical compound accumulation abnormal polyphosphate 1 YHR179W OYE2 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YIL097W FYV10 systematic mutation set Cell wall morphology abnormal 1 YFL025C BST1 classical genetics Protein transport abnormal defects in ER protein retention and cargo sorting 1 YFL025C BST1 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; severe defect 1 YFL025C BST1 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 1 YFL025C BST1 systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 1 YFL025C BST1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YFR007W YFH7 large-scale survey Mitochondrial genome maintenance abnormal decreased frequency of spontaneous mitochondrial genome loss 1 YDR372C VPS74 classical genetics Protein/peptide distribution abnormal Kre2CT-mRFP (mislocalized to vacuole) 1 YDR372C VPS74 classical genetics Protein/peptide distribution abnormal Ktr6CT-GFP construct (mislocalized to vacuole) 1 YDR372C VPS74 classical genetics Protein/peptide distribution abnormal Mnn2-GFP construct (mislocalized to vacuole) 1 YDR372C VPS74 classical genetics Protein/peptide distribution abnormal Mnn9-GFP construct (mislocalized to a vesicle-like haze) 1 YDR372C VPS74 systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 1 YGL236C MTO1 classical genetics Respiratory metabolism abnormal "O2 consumption is decreased, although respiratory growth on glycerol is wild-type" 1 YJL154C VPS35 systematic mutation set Lipid particle morphology abnormal 1 YJL154C VPS35 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YJR100C AIM25 large-scale survey Mitochondrial genome maintenance abnormal increased frequency of spontaneous mitochondrial genome loss 1 YLR032W RAD5 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 1 YLR032W RAD5 classical genetics Chromosome/plasmid maintenance abnormal gross chromosomal rearrangements increased by at least 10-fold relative to wildtype 1 YLR032W RAD5 classical genetics Chromosome/plasmid maintenance abnormal "increased rate of gross-chromosomal rearrangement (GCR), indicative of genome instability (181-fold relative to wildtype)" 1 YLR032W RAD5 homozygous diploid Chromosome/plasmid maintenance abnormal indicative of chromosome instability (CIN); high confidence set; 2-fold increase over wildtype;diploid bimater (BiM) assay 1 YLR374C classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 1 YLR374C homozygous diploid Chromosome/plasmid maintenance abnormal indicative of chromosome instability (CIN); high confidence set; >= 5-fold increase over wildtype;diploid bimater (BiM) assay 1 YLR374C systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Protein/peptide distribution abnormal "CPY is secreted rather than retained in the cell, and this phenotype is suppressed by supplementation with 500 mM KCl" Prc1p (CPY) 1 YML097C VPS9 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 1 YML115C VAN1 systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 1 YML117W NAB6 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YNL097C PHO23 classical genetics Protein/peptide distribution abnormal no obvious foci; diffused fluorescence in the entire nucleus GFP-Rap1 1 YNR052C POP2 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at the MET15 locus increased 20-fold or greater, at SAM2 increased 6-20 fold, and at MAT increased 2-6 fold" 1 YNR052C POP2 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; moderate defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 1 YOL004W SIN3 classical genetics Chromosome/plasmid maintenance abnormal increased frequency of gross chromosomal rearrangements (chromosomal instability is due to the accumulation of RNA-DNA hybrids that can cause DSBs) 1 YOL004W SIN3 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 1 YOR069W VPS5 systematic mutation set Chemical compound accumulation abnormal polyphosphate 1 YOR069W VPS5 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 1 YOR330C MIP1 classical genetics Mitochondrial genome maintenance abnormal nucleoids are absent in at least 95% of cells after cytoduction 1 YOR330C MIP1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 1 YPR123C systematic mutation set Protein/peptide distribution abnormal type I mutants display a dot-like intracellular localization in addition to plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 1 YDR372C VPS74 classical genetics Protein/peptide modification absent Gas1p (N- and O-linked carbohydrates not added) 1 YGL115W SNF4 classical genetics Dessication resistance absent mutants grown to post-diauxic phase and then subject to desiccation intolerant with less than 10% survival after the drying process 1 YGL115W SNF4 classical genetics Utilization of carbon source absent raffinose 1 YGL115W SNF4 systematic mutation set Respiratory growth absent glycerol carbon source 1 YGL236C MTO1 classical genetics RNA modification absent mitochondrial tRNA-Lys does not contain 5-carboxymethylaminomethyl-2-thiouridine mt tRNA-Lys 1 YJL201W ECM25 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 1 YLR125W systematic mutation set Respiratory growth absent glycerol carbon source 1 YLR201C COQ9 systematic mutation set Respiratory growth absent glycerol carbon source 1 YLR201C COQ9 systematic mutation set Respiratory growth absent glycerol carbon source 1 YLR203C MSS51 large-scale survey Respiratory growth absent nonfermentable carbon source (2% glycerol) 1 YLR203C MSS51 systematic mutation set Respiratory growth absent glycerol carbon source 1 YLR203C MSS51 systematic mutation set Respiratory growth absent glycerol carbon source 1 YML097C VPS9 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 1 YNL041C COG6 "homozygous diploid, systematic mutation set" Respiratory growth absent glycerol 1 YNR041C COQ2 systematic mutation set Respiratory growth absent glycerol carbon source 1 YNR041C COQ2 systematic mutation set Respiratory growth absent glycerol carbon source 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Sporulation absent 1 YOL004W SIN3 classical genetics Respiratory growth absent ethanol (1 %) mitochondrial DNA remains present as observed by DAPI staining;also observed in media containing 1% ethanol and 2% glycerol 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Respiratory growth absent glycerol 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Sporulation absent 1 YOL051W GAL11 classical genetics Utilization of carbon source absent oleic acid 1 YOL051W GAL11 systematic mutation set Respiratory growth absent glycerol carbon source 1 YOR330C MIP1 systematic mutation set Respiratory growth absent glycerol carbon source 1 YOR330C MIP1 systematic mutation set Respiratory growth absent glycerol carbon source 1 YPR123C systematic mutation set Respiratory growth absent glycerol carbon source 1 YBL017C PEP1 competitive growth Competitive fitness decreased minimal medium 1 YBL051C PIN4 competitive growth Competitive fitness decreased minimal medium 1 YBL051C PIN4 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YBL051C PIN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 1 YBL051C PIN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YBL051C PIN4 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;partial growth inhibition on exposure to 66% zymocin; not inhibited by 33% zymocin 1 YBL051C PIN4 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YBL051C PIN4 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 1 YBL051C PIN4 systematic mutation set Oxidative stress resistance decreased hydrogen peroxide (4 mM) 1 YBL051C PIN4 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YBL051C PIN4 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YBL051C PIN4 systematic mutation set Resistance to chemicals decreased rapamycin 1 YBL051C PIN4 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YBL051C PIN4 systematic mutation set Resistance to chemicals decreased wortmannin 1 YBL104C SEA4 competitive growth Competitive fitness decreased minimal medium 1 YBL104C SEA4 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YBR174C competitive growth Competitive fitness decreased minimal medium 1 YBR174C "homozygous diploid, competitive growth" UV resistance decreased "high sensitivity, three or more relative fitness ratios below 0.92" 1 YBR174C "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YBR174C "homozygous diploid, systematic mutation set" Sporulation decreased 1 YBR174C "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YBR174C systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YBR194W AIM4 competitive growth Competitive fitness decreased minimal medium 1 YBR194W AIM4 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YBR194W AIM4 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YBR194W AIM4 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YBR194W AIM4 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 1 YBR194W AIM4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 1 YBR194W AIM4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 1 YBR194W AIM4 systematic mutation set Oxidative stress resistance decreased tert-butyl hydroperoxide (t-BuOOH) 1 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased 4-nitroquinoline N-oxide 1 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type 1 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YBR194W AIM4 systematic mutation set UV resistance decreased UV irradiation (254 nm) 1 YBR205W KTR3 competitive growth Competitive fitness decreased minimal medium 1 YBR216C YBP1 competitive growth Competitive fitness decreased minimal medium 1 YBR216C YBP1 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased hydrogen peroxide decreased viability in high concentrations of H2O2 after exposure to low concentrations 1 YBR216C YBP1 systematic mutation set Oxidative stress resistance decreased cumene hydroperoxide (0.125 mM) 1 YBR216C YBP1 systematic mutation set Oxidative stress resistance decreased hydrogen peroxide (4 mM) 1 YBR216C YBP1 systematic mutation set Oxidative stress resistance decreased linoleic acid hydroperoxide (0.2 mM) 1 YBR231C SWC5 competitive growth Competitive fitness decreased minimal medium 1 YBR231C SWC5 homozygous diploid Resistance to chemicals decreased benomyl (10 ug/ml) 1 YBR231C SWC5 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YBR231C SWC5 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YBR231C SWC5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased benomyl (15 ug/ml) moderate growth defect 1 YBR231C SWC5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 1 YBR231C SWC5 "homozygous diploid, systematic mutation set" Toxin resistance decreased partial growth inhibition on exposure to 66% zymocin; not inhibited by 33% zymocin;K. lactis zymocin 1 YBR231C SWC5 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 1 YBR231C SWC5 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YBR231C SWC5 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YBR231C SWC5 systematic mutation set Competitive fitness decreased nystatin (10 microM) 1 YBR231C SWC5 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) moderate sensitivity 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased Calcofluor White 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 1 YBR231C SWC5 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 1 YBR255W MTC4 classical genetics Metal resistance decreased nickel(2+) 1 YBR255W MTC4 classical genetics Resistance to chemicals decreased mycophenolic acid (30 micrograms/ml) hypersensitive 1 YBR255W MTC4 classical genetics Toxin resistance decreased "HD20Q (Huntingtin protein, exon1 containing 20 polyglutamine repeats)" 1 YBR255W MTC4 competitive growth Competitive fitness decreased minimal medium 1 YBR255W MTC4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 1 YBR255W MTC4 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 1 YBR255W MTC4 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YBR255W MTC4 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YBR255W MTC4 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) hypersensitive 1 YBR255W MTC4 systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 1 YCL005W LDB16 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YCL005W LDB16 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YCL005W LDB16 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YCL005W LDB16 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 1 YCL005W LDB16 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YCL005W LDB16 systematic mutation set Competitive fitness decreased nystatin (10 microM) 1 YCL005W LDB16 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YCL005W LDB16 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) weak sensitivity 1 YCL005W LDB16 systematic mutation set Resistance to chemicals decreased rapamycin 1 YCL005W LDB16 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) weak sensitivity 1 YCL005W LDB16 systematic mutation set Resistance to chemicals decreased wortmannin 1 YCL011C GBP2 competitive growth Competitive fitness decreased minimal medium 1 YCL011C GBP2 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 1 YCL014W BUD3 competitive growth Competitive fitness decreased minimal medium 1 YCL061C MRC1 competitive growth Competitive fitness decreased minimal medium 1 YCL061C MRC1 heterozygous diploid Resistance to chemicals decreased St. John's Wort extract 1 YCL061C MRC1 "heterozygous diploid, competitive growth" Resistance to chemicals decreased St. John's Wort extract 1 YCL061C MRC1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YCL061C MRC1 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "high sensitivity, both relative fitness ratios below 0.88" 1 YCL061C MRC1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YCL061C MRC1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YCL061C MRC1 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YCL061C MRC1 systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YCL061C MRC1 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) weak sensitivity 1 YCL061C MRC1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 1 YCL061C MRC1 systematic mutation set Telomere length decreased 1 YCL061C MRC1 systematic mutation set Thermotolerance decreased "pretreatment at 37 deg C for 30 min, then heat shock at 50 deg C for 30 min" 1 YCR004C YCP4 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 1 YCR034W FEN1 classical genetics Resistance to chemicals decreased Calcofluor White (25 ug/ml) intermediate sensitivity 1 YCR034W FEN1 classical genetics Resistance to chemicals decreased oleate (0.1%) 1 YCR034W FEN1 classical genetics Toxin resistance decreased alpha-synuclein 1 YCR034W FEN1 competitive growth Competitive fitness decreased minimal medium 1 YCR034W FEN1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YCR034W FEN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 1 YCR034W FEN1 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YCR034W FEN1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 1 YCR034W FEN1 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - trp medium) 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased monensin (50 uM) hypersensitive 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased rapamycin 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased wortmannin 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) strong sensitivity 1 YCR034W FEN1 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 1 YCR049C systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 1 YCR049C systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YCR061W competitive growth Competitive fitness decreased minimal medium 1 YCR061W "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YCR061W "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YCR061W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 1 YCR061W large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YCR061W systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YCR061W systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 1 YCR088W ABP1 classical genetics Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 reporter" 1 YCR088W ABP1 classical genetics Resistance to chemicals decreased sodium chloride (5%) viability reduced relative to wildtype at all time points examined 1 YCR088W ABP1 competitive growth Competitive fitness decreased minimal medium 1 YCR088W ABP1 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YCR088W ABP1 homozygous diploid Sporulation efficiency decreased threefold reduction relative to wildtype 1 YCR088W ABP1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YEL042W GDA1 classical genetics Toxin resistance decreased "HD20Q (Huntingtin protein, exon1 containing 20 polyglutamine repeats)" 1 YEL042W GDA1 classical genetics Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 1 YEL042W GDA1 competitive growth Competitive fitness decreased minimal medium 1 YEL042W GDA1 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YEL042W GDA1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YEL042W GDA1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YEL042W GDA1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YEL042W GDA1 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 1 YEL042W GDA1 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 1 YEL042W GDA1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 1 YEL042W GDA1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YEL042W GDA1 systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 1 YEL053C MAK10 competitive growth Competitive fitness decreased minimal medium 1 YEL053C MAK10 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YEL053C MAK10 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 1 YEL053C MAK10 systematic mutation set Mitophagy decreased growth on lactate carbon source to post-log phase slight decrease 1 YEL053C MAK10 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 1 YEL053C MAK10 systematic mutation set Resistance to chemicals decreased rapamycin 1 YEL053C MAK10 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 1 YEL053C MAK10 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YEL060C PRB1 competitive growth Competitive fitness decreased minimal medium 1 YEL060C PRB1 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YEL060C PRB1 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YEL060C PRB1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YEL060C PRB1 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 1 YEL060C PRB1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 1 YEL060C PRB1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YEL060C PRB1 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 1 YEL060C PRB1 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 1 YER028C MIG3 competitive growth Competitive fitness decreased minimal medium 1 YER028C MIG3 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YER028C MIG3 homozygous diploid Chronological lifespan decreased 1 YER028C MIG3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YER028C MIG3 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 1 YER028C MIG3 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YER028C MIG3 systematic mutation set Transposable element transposition decreased moderate decrease in Ty1 mobility 1 YER164W CHD1 classical genetics Protein/peptide modification decreased significant decrease in H2B monoubiquitination histone H2B 1 YER164W CHD1 competitive growth Competitive fitness decreased minimal medium 1 YER164W CHD1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YER169W RPH1 competitive growth Competitive fitness decreased minimal medium 1 YHL002W HSE1 classical genetics Resistance to chemicals decreased caffeine (15 mM) 1 YHL002W HSE1 competitive growth Competitive fitness decreased minimal medium 1 YHL002W HSE1 systematic mutation set Chitin deposition decreased 1 YHL002W HSE1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YHL002W HSE1 systematic mutation set Resistance to chemicals decreased Calcofluor White 1 YHL008C classical genetics Chemical compound accumulation decreased chloride 1 YHL008C competitive growth Competitive fitness decreased minimal medium 1 YHR179W OYE2 competitive growth Competitive fitness decreased minimal medium 1 YHR179W OYE2 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YHR179W OYE2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 1 YIL097W FYV10 classical genetics Resistance to chemicals decreased hydrogen peroxide (2.5 mM) 1 YIL097W FYV10 classical genetics Resistance to chemicals decreased rapamycin hypersensitive 1 YIL097W FYV10 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YIL097W FYV10 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YIL097W FYV10 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 1 YIL097W FYV10 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YIL097W FYV10 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 1 YIL097W FYV10 systematic mutation set Killer toxin resistance decreased 1 YIL097W FYV10 systematic mutation set Resistance to chemicals decreased 6-azauracil 1 YIL097W FYV10 systematic mutation set Resistance to chemicals decreased "CTBT (4 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 4 ug/ml CTBT 1 YIL097W FYV10 systematic mutation set Resistance to chemicals decreased hygromycin B 1 YIL097W FYV10 systematic mutation set Resistance to chemicals decreased mycophenolic acid 1 YIL097W FYV10 systematic mutation set Resistance to chemicals decreased sodium dodecyl sulfate (0.05%) 1 YKL136W competitive growth Competitive fitness decreased minimal medium 1 YKL136W systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 1 YKL136W systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YKL190W CNB1 classical genetics Ionic stress resistance decreased lithium(1+) (35-50 mM lithium chloride) 1 YKL190W CNB1 competitive growth Competitive fitness decreased minimal medium 1 YKL190W CNB1 homozygous diploid Resistance to chemicals decreased "L-1,4-dithiothreitol" 1 YKL190W CNB1 homozygous diploid Resistance to chemicals decreased mercaptoethanol (30 mM) 1 YKL190W CNB1 homozygous diploid Resistance to chemicals decreased Plakortide F acid (~0.3 ug/ml) 1 YKL190W CNB1 homozygous diploid Resistance to chemicals decreased tunicamycin (1 microgram/mL) 1 YKL190W CNB1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YKL190W CNB1 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 1 YKL190W CNB1 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 1 YKL190W CNB1 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.1 M LiCl) 1 YKL190W CNB1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 1 YKL190W CNB1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 1 YKL190W CNB1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 1 YKL190W CNB1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 1 YKL190W CNB1 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 1 YKL190W CNB1 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 1 YKL190W CNB1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 1 YKL190W CNB1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 1 YKL190W CNB1 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 1 YKL190W CNB1 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 1 YKL190W CNB1 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased miconazole at least 4-fold reduced MIC compared to 1 ug/ml wt MIC 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) strong sensitivity 1 YKL190W CNB1 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 1 YFL031W HAC1 classical genetics Resistance to chemicals decreased "L-1,4-dithiothreitol (5 mM)" sensitive under both aerobic and anaerobic conditions 1 YFL031W HAC1 classical genetics Resistance to chemicals decreased tunicamycin (1 ug/ml) sensitive under both aerobic and anaerobic conditions 1 YFL031W HAC1 competitive growth Competitive fitness decreased minimal medium 1 YFL031W HAC1 homozygous diploid Resistance to chemicals decreased "L-1,4-dithiothreitol" 1 YFL031W HAC1 homozygous diploid Resistance to chemicals decreased mercaptoethanol (30 mM) 1 YFL031W HAC1 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 1 YFL031W HAC1 homozygous diploid Resistance to chemicals decreased tunicamycin (1 microgram/mL) 1 YFL031W HAC1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 1 YFL031W HAC1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 1 YFL031W HAC1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 1 YFL031W HAC1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YFL031W HAC1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YFL031W HAC1 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) strong sensitivity 1 YFL025C BST1 classical genetics Protein/peptide modification decreased Gas1p accumulates in precursor form Gas1p 1 YFL025C BST1 competitive growth Competitive fitness decreased minimal medium 1 YFL025C BST1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YFL025C BST1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YFL025C BST1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YFL025C BST1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 1 YFL025C BST1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 1 YFL025C BST1 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YFL025C BST1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased rapamycin 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YFR006W competitive growth Competitive fitness decreased minimal medium 1 YFR007W YFH7 competitive growth Competitive fitness decreased minimal medium 1 YFR007W YFH7 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YFR007W YFH7 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YDL218W large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YDL241W competitive growth Competitive fitness decreased minimal medium 1 YDL241W "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YDL241W systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 1 YDR123C INO2 competitive growth Competitive fitness decreased minimal medium 1 YDR123C INO2 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YDR123C INO2 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 1 YDR123C INO2 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 1 YDR123C INO2 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YDR123C INO2 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YDR123C INO2 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YDR123C INO2 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 1 YDR372C VPS74 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form in the presence of monensin carboxypeptidase Y (Prc1p) 1 YDR372C VPS74 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YDR372C VPS74 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YDR372C VPS74 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YDR372C VPS74 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 1 YDR372C VPS74 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YDR372C VPS74 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 1 YDR372C VPS74 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YDR372C VPS74 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 1 YDR372C VPS74 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 1 YDR372C VPS74 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YDR372C VPS74 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 1 YDR372C VPS74 systematic mutation set Resistance to chemicals decreased PM02734 (250 ug/ml; synthetic cyclic depsipeptide related to natural kahalalides) 1 YDR372C VPS74 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 1 YDR438W THI74 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YDR455C classical genetics Resistance to chemicals decreased gentamycin (500 ug/ml) growth inhibited by over 80% 1 YDR455C competitive growth Competitive fitness decreased minimal medium 1 YDR455C homozygous diploid Resistance to chemicals decreased BPS (100 uM bathophenanthrolinebisulfonic acid) displays sensitivity in liquid SD plus BPS but not on solid YPD plus BPS 1 YDR455C "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 1 YDR455C "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 1 YDR455C "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YDR455C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 1 YDR455C "homozygous diploid, systematic mutation set" Sporulation decreased 1 YDR455C large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YDR455C large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YDR455C systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YDR455C systematic mutation set Resistance to chemicals decreased Echinacea extract 1 YDR456W NHX1 classical genetics Acid pH resistance decreased pH 2.7 medium 1 YDR456W NHX1 classical genetics Chemical compound accumulation decreased chloride 1 YDR456W NHX1 classical genetics Ionic stress resistance decreased potassium chloride (0.8 M) 1 YDR456W NHX1 classical genetics Resistance to chemicals decreased gentamycin (500 ug/ml) growth inhibited by 80% 1 YDR456W NHX1 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 1 YDR456W NHX1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 1 YDR456W NHX1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 1 YDR456W NHX1 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 1 YDR456W NHX1 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 1 YDR456W NHX1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YDR538W PAD1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YDR538W PAD1 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YGL115W SNF4 competitive growth Competitive fitness decreased minimal medium 1 YGL115W SNF4 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YGL115W SNF4 homozygous diploid Resistance to chemicals decreased benomyl (10 ug/ml) 1 YGL115W SNF4 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YGL115W SNF4 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YGL115W SNF4 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YGL115W SNF4 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 1 YGL115W SNF4 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YGL115W SNF4 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YGL115W SNF4 systematic mutation set Competitive fitness decreased galactose 1 YGL115W SNF4 systematic mutation set Resistance to chemicals decreased leucascandrolide A analog 3 (5 nM) 1 YGL115W SNF4 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 1 YGL115W SNF4 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 1 YGL115W SNF4 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 1 YGL147C RPL9A competitive growth Competitive fitness decreased minimal medium 1 YGL147C RPL9A "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YGL147C RPL9A "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YGL147C RPL9A "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YGL198W YIP4 competitive growth Competitive fitness decreased minimal medium 1 YGL198W YIP4 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YGL198W YIP4 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YGL215W CLG1 competitive growth Competitive fitness decreased minimal medium 1 YGL215W CLG1 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YGL236C MTO1 competitive growth Competitive fitness decreased minimal medium 1 YGL236C MTO1 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YGL236C MTO1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YGL254W FZF1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YGL254W FZF1 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 1 YGL254W FZF1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 1 YGR289C MAL11 competitive growth Competitive fitness decreased minimal medium 1 YGR289C MAL11 "heterozygous diploid, competitive growth" Resistance to chemicals decreased alverine citrate (500 uM) 1 YGR289C MAL11 "heterozygous diploid, competitive growth" Resistance to chemicals decreased fenpropimorph (2.3 uM) 1 YGR289C MAL11 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YGR289C MAL11 systematic mutation set Competitive fitness decreased nystatin (10 microM) 1 YGR289C MAL11 systematic mutation set Competitive fitness decreased nystatin (10 microM) 1 YGR289C MAL11 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - trp medium) 1 YJL082W IML2 competitive growth Competitive fitness decreased minimal medium 1 YJL082W IML2 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YJL082W IML2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YJL082W IML2 systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YJL135W systematic mutation set Toxin resistance decreased alpha-synuclein 1 YJL154C VPS35 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 1 YJL154C VPS35 competitive growth Competitive fitness decreased minimal medium 1 YJL154C VPS35 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YJL154C VPS35 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 1 YJL154C VPS35 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 1 YJL154C VPS35 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 1 YJL154C VPS35 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YJL154C VPS35 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YJL154C VPS35 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YJL154C VPS35 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 1 YJL154C VPS35 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 1 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 1 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 1 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased rapamycin 1 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 1 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YJL162C JJJ2 competitive growth Competitive fitness decreased minimal medium 1 YJL162C JJJ2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 1 YJL162C JJJ2 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 1 YJL201W ECM25 competitive growth Competitive fitness decreased minimal medium 1 YJL201W ECM25 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 1 YJL201W ECM25 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YJL201W ECM25 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 1 YJL201W ECM25 systematic mutation set Oxidative stress resistance decreased cumene hydroperoxide (0.125 mM) 1 YJL201W ECM25 systematic mutation set Oxidative stress resistance decreased linoleic acid hydroperoxide (0.2 mM) 1 YJL217W REE1 competitive growth Competitive fitness decreased minimal medium 1 YJL217W REE1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YJL217W REE1 large-scale survey Metal resistance decreased copper(2+) sulfate (2.5 mM) strong phenotype 1 YJR100C AIM25 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YLR003C CMS1 competitive growth Competitive fitness decreased minimal medium 1 YLR003C CMS1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 1 YLR032W RAD5 classical genetics Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine (4.45 uM)" 1 YLR032W RAD5 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 1 YLR032W RAD5 classical genetics Resistance to chemicals decreased selenite(2-) 1 YLR032W RAD5 classical genetics Resistance to chemicals decreased selenomethionine 1 YLR032W RAD5 classical genetics UV resistance decreased chronic low-dose UV light (CLUV) (incubated under continuous exposure to UV irradiation (254 nm) at a dose of approximately 0.12 J/m2 per min.) 1 YLR032W RAD5 competitive growth Competitive fitness decreased minimal medium 1 YLR032W RAD5 "heterozygous diploid, competitive growth" Resistance to chemicals decreased cisplatin (125 uM) 1 YLR032W RAD5 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YLR032W RAD5 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YLR032W RAD5 "homozygous diploid, competitive growth" Gamma ray resistance decreased 1 YLR032W RAD5 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YLR032W RAD5 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine (9 uM)" 1 YLR032W RAD5 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "high sensitivity, both relative fitness ratios below 0.88" 1 YLR032W RAD5 "homozygous diploid, competitive growth" UV resistance decreased "high sensitivity, three or more relative fitness ratios below 0.92" 1 YLR032W RAD5 "homozygous diploid, competitive growth" UV resistance decreased sensitive to both UVB and UVC irradiation 1 YLR032W RAD5 "homozygous diploid, large-scale survey" Resistance to chemicals decreased cisplatin (250 ug/ml) 1 YLR032W RAD5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 1 YLR032W RAD5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 1 YLR032W RAD5 "homozygous diploid, systematic mutation set" UV resistance decreased UV at 100 J/m2 strong growth defect 1 YLR032W RAD5 systematic mutation set Resistance to chemicals decreased formaldehyde (1.5 mM) 1 YLR032W RAD5 systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YLR032W RAD5 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 1 YLR032W RAD5 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YLR032W RAD5 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 1 YLR032W RAD5 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 1 YLR125W systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YLR125W systematic mutation set Resistance to chemicals decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type 1 YLR201C COQ9 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YLR201C COQ9 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YLR201C COQ9 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YLR201C COQ9 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YLR201C COQ9 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YLR201C COQ9 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YLR201C COQ9 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 1 YLR201C COQ9 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YLR203C MSS51 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YLR203C MSS51 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YLR203C MSS51 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YLR203C MSS51 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YLR203C MSS51 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YLR203C MSS51 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YLR203C MSS51 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YLR374C competitive growth Competitive fitness decreased minimal medium 1 YLR374C "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 1 YLR374C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 1 YLR374C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 1 YLR374C "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 1 YLR374C systematic mutation set Competitive fitness decreased nystatin (10 microM) 1 YLR374C systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) weak sensitivity 1 YLR446W competitive growth Competitive fitness decreased minimal medium 1 YLR446W large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YLR446W large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 1 YML071C COG8 competitive growth Competitive fitness decreased minimal medium 1 YML071C COG8 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 1 YML071C COG8 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YML071C COG8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YML071C COG8 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 1 YML071C COG8 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YML071C COG8 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 1 YML071C COG8 systematic mutation set Metal resistance decreased aluminium(3+) (0.6 mM) 1 YML071C COG8 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 1 YML097C VPS9 classical genetics Protein/peptide modification decreased reduced processing of Prc1p to mature form carboxypeptidase Y (Prc1p) 1 YML097C VPS9 competitive growth Competitive fitness decreased minimal medium 1 YML097C VPS9 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Acid pH resistance decreased strong growth defect;pH 3.0 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 1 YML097C VPS9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 1 YML097C VPS9 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 1 YML097C VPS9 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YML097C VPS9 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 1 YML097C VPS9 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 1 YML097C VPS9 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased formaldehyde (1.5 mM) 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased monensin (50 uM) hypersensitive 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased rapamycin 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YML097C VPS9 systematic mutation set Telomere length decreased 1 YML097C VPS9 systematic mutation set Transposable element transposition decreased Ty3 1 YML101C-A competitive growth Competitive fitness decreased minimal medium 1 YML101C-A systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YML115C VAN1 classical genetics Survival rate in stationary phase decreased "10,000-fold reduction in colony-forming potential after 25 days in water, without losing viability" 1 YML115C VAN1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YML115C VAN1 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YML115C VAN1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 1 YML115C VAN1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased Calcofluor White 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased hygromycin B (slow growth at 25 ug/mL and 50 ug/mL) 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased rapamycin 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 1 YML117W NAB6 competitive growth Competitive fitness decreased minimal medium 1 YML117W NAB6 homozygous diploid Gamma ray resistance decreased 1 YML117W NAB6 "homozygous diploid, competitive growth" Gamma ray resistance decreased 1 YML117W NAB6 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YML117W NAB6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 1 YML117W NAB6 "homozygous diploid, systematic mutation set" Toxin resistance decreased partial growth inhibition on exposure to 66% zymocin; not inhibited by 33% zymocin;K. lactis zymocin 1 YML117W NAB6 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 1 YML117W NAB6 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 1 YML119W competitive growth Competitive fitness decreased minimal medium 1 YMR183C SSO2 competitive growth Competitive fitness decreased minimal medium 1 YMR183C SSO2 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 1 YMR183C SSO2 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 1 YMR183C SSO2 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YNL041C COG6 classical genetics Toxin resistance decreased alpha-synuclein 1 YNL041C COG6 competitive growth Competitive fitness decreased minimal medium 1 YNL041C COG6 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 1 YNL041C COG6 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YNL041C COG6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 1 YNL041C COG6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 1 YNL041C COG6 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 1 YNL041C COG6 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YNL041C COG6 systematic mutation set Metal resistance decreased aluminium(3+) (0.6 mM) 1 YNL041C COG6 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 1 YNL041C COG6 systematic mutation set Resistance to chemicals decreased PM02734 (250 ug/ml; synthetic cyclic depsipeptide related to natural kahalalides) 1 YNL041C COG6 systematic mutation set Toxin resistance decreased alpha-synuclein 1 YNL076W MKS1 competitive growth Competitive fitness decreased minimal medium 1 YNL076W MKS1 "heterozygous diploid, competitive growth" Resistance to chemicals decreased 5-fluorouracil (19.2 uM) 1 YNL076W MKS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 1 YNL076W MKS1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YNL076W MKS1 systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YNL097C PHO23 competitive growth Competitive fitness decreased minimal medium 1 YNL097C PHO23 "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YNL097C PHO23 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YNL097C PHO23 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 1 YNL097C PHO23 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YNL097C PHO23 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 1 YNL097C PHO23 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 1 YNL097C PHO23 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 1 YNL097C PHO23 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YNL097C PHO23 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YNL097C PHO23 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 1 YNL097C PHO23 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 1 YNL097C PHO23 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YNL097C PHO23 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 1 YNL097C PHO23 systematic mutation set Resistance to chemicals decreased wortmannin 1 YNL170W competitive growth Competitive fitness decreased minimal medium 1 YNL170W "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased tenovin-6 (20 micromolar) authors note overlap with adjacent ORF PSD1 1 YNL170W "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YNL170W "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YNL170W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 1 YNL170W "homozygous diploid, systematic mutation set" Sporulation decreased 1 YNL170W systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete medium) 1 YNL212W VID27 competitive growth Competitive fitness decreased minimal medium 1 YNR041C COQ2 competitive growth Competitive fitness decreased minimal medium 1 YNR041C COQ2 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 1 YNR041C COQ2 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 1 YNR041C COQ2 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YNR041C COQ2 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YNR041C COQ2 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YNR041C COQ2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 1 YNR041C COQ2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) strong growth defect 1 YNR041C COQ2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YNR052C POP2 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 1 YNR052C POP2 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 1 YNR052C POP2 classical genetics Protein/peptide accumulation decreased decreased abundance of the Gag major capsid protein of retrotranposon Ty1 virus-like particles Gag 1 YNR052C POP2 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 1 YNR052C POP2 classical genetics Resistance to chemicals decreased hydroxyurea (50 mM) 1 YNR052C POP2 classical genetics Resistance to chemicals decreased zymocin (45% (v/v)) 1 YNR052C POP2 classical genetics RNA accumulation decreased "hydroxyurea (200 mM, 1 hr)" RNR3 mRNA 1 YNR052C POP2 classical genetics RNA accumulation decreased "hydroxyurea (200 mM, 1 hr)" RNR4 mRNA 1 YNR052C POP2 classical genetics RNA accumulation decreased "methyl methanesulfonate (0.01%, 2 hr)" RNR2 mRNA 1 YNR052C POP2 classical genetics RNA accumulation decreased "methyl methanesulfonate (0.01%, 2 hr)" RNR3 mRNA 1 YNR052C POP2 classical genetics RNA accumulation decreased "methyl methanesulfonate (0.01%, 2 hr)" RNR4 mRNA 1 YNR052C POP2 homozygous diploid Protein/peptide accumulation decreased "most cells lack a detectable signal, and remainder have a weak signal at the bud tip" Bud8p-GFP 1 YNR052C POP2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YNR052C POP2 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Acid pH resistance decreased pH 3.0;moderate growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased benomyl (15 ug/ml) strong growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) strong growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 1 YNR052C POP2 "homozygous diploid, systematic mutation set" UV resistance decreased UV at 100 J/m2 moderate growth defect 1 YNR052C POP2 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 1 YNR052C POP2 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YNR052C POP2 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 1 YNR052C POP2 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) strong sensitivity 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) strong sensitivity 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) moderate sensitivity 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased caspofungin 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased hydroxyurea 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 1 YNR052C POP2 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 1 YOL004W SIN3 classical genetics Dessication resistance decreased mutants grown to post-diauxic phase and then subject to desiccation severely affected with 10-34% survival after desiccation 1 YOL004W SIN3 classical genetics Metal resistance decreased nickel(2+) 1 YOL004W SIN3 competitive growth Competitive fitness decreased minimal medium 1 YOL004W SIN3 homozygous diploid Resistance to chemicals decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM) 1 YOL004W SIN3 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 1 YOL004W SIN3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YOL004W SIN3 "homozygous diploid, competitive growth" UV resistance decreased "moderate sensitivity, two relative fitness ratios below 0.92" 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 1 YOL004W SIN3 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 1 YOL004W SIN3 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YOL004W SIN3 systematic mutation set Competitive fitness decreased nystatin (10 microM) 1 YOL004W SIN3 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) weak sensitivity 1 YOL004W SIN3 systematic mutation set Telomere length decreased 1 YOL051W GAL11 classical genetics Protein/peptide modification decreased reduced processing of Prc1p to mature form carboxypeptidase Y (Prc1p) 1 YOL051W GAL11 classical genetics RNA accumulation decreased oleic acid containing media "oleate-induction absent, compared to the wild-type control" FOX2 mRNA 1 YOL051W GAL11 classical genetics RNA accumulation decreased oleic acid containing media "oleate-induction absent, compared to the wild-type control" FOX3 mRNA 1 YOL051W GAL11 homozygous diploid Resistance to chemicals decreased bathophenanthroline bisulfonate (BPS) (80 uM) 1 YOL051W GAL11 homozygous diploid Resistance to chemicals decreased curcumin (150 uM) curcumin sensitivity is rescued by addition of 50 uM Fe2SO4 1 YOL051W GAL11 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 1 YOL051W GAL11 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 1 YOL051W GAL11 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased hydrogen peroxide decreased viability in high concentrations of H2O2 after exposure to low concentrations 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 1 YOL051W GAL11 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 1 YOL051W GAL11 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) fails to grow in 100% oxygen atmosphere 1 YOL051W GAL11 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) decreased growth in 0.5 mM paraquat 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) moderate sensitivity 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) strong sensitivity 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased monensin (50 uM) moderately sensitive 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) moderate sensitivity 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) moderate sensitivity 1 YOL051W GAL11 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) moderate sensitivity 1 YOL051W GAL11 systematic mutation set Telomere length decreased 1 YOL059W GPD2 competitive growth Competitive fitness decreased minimal medium 1 YOL098C classical genetics Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 reporter" 1 YOL098C "heterozygous diploid, competitive growth" Starvation resistance decreased 1 YOR069W VPS5 classical genetics Viability decreased nitrogen starvation 1 YOR069W VPS5 competitive growth Competitive fitness decreased minimal medium 1 YOR069W VPS5 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 1 YOR069W VPS5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 1 YOR069W VPS5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 1 YOR069W VPS5 "homozygous diploid, systematic mutation set" Sporulation decreased 1 YOR069W VPS5 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 1 YOR069W VPS5 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 1 YOR069W VPS5 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 1 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 1 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 1 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 1 YOR132W VPS17 competitive growth Competitive fitness decreased minimal medium 1 YOR132W VPS17 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 1 YOR132W VPS17 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 1 YOR132W VPS17 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 1 YOR132W VPS17 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 1 YOR132W VPS17 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 1 YOR132W VPS17 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 1 YOR330C MIP1 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YOR330C MIP1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 1 YOR330C MIP1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 1 YOR330C MIP1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YOR330C MIP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 1 YOR330C MIP1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 1 YOR330C MIP1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 1 YOR330C MIP1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 1 YOR330C MIP1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 1 YOR330C MIP1 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 1 YOR330C MIP1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YOR330C MIP1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YOR360C PDE2 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 1 YOR360C PDE2 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 1 YOR360C PDE2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 1 YOR360C PDE2 systematic mutation set Thermotolerance decreased "pretreatment at 37 deg C for 30 min, then heat shock at 50 deg C for 30 min" 1 YOR360C PDE2 systematic mutation set Transposable element transposition decreased moderate decrease in Ty1 mobility 1 YPR123C competitive growth Competitive fitness decreased minimal medium 1 YPR123C "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 1 YPR123C "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 1 YPR123C "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 1 YPR123C "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) strong growth defect 1 YPR123C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 1 YPR123C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 1 YPR123C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) strong growth defect 1 YPR123C "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 1 YPR123C "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 1 YPR123C systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 1 YPR123C systematic mutation set Resistance to chemicals decreased ethanol (8%) 1 YPR123C systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 1 YPR199C ARR1 competitive growth Competitive fitness decreased minimal medium 1 YPR199C ARR1 "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased sodium arsenite (450 uM) 1 YPR199C ARR1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 1 YBL051C PIN4 systematic mutation set Vegetative growth decreased rate 1 YBR174C systematic mutation set Vegetative growth decreased rate 1 YBR194W AIM4 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 1 YEL053C MAK10 systematic mutation set Vegetative growth decreased rate 1 YER028C MIG3 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YER028C MIG3 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YER164W CHD1 systematic mutation set Vegetative growth decreased rate 1 YHL008C classical genetics Chemical compound accumulation decreased rate chloride 1 YHR179W OYE2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YHR179W OYE2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YFL031W HAC1 systematic mutation set Vegetative growth decreased rate 1 YDR455C "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YDR455C "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YDR456W NHX1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YDR456W NHX1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YGL115W SNF4 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YGL115W SNF4 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YGL147C RPL9A classical genetics Vegetative growth decreased rate 1 YGL147C RPL9A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 1 YGL147C RPL9A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 1 YGL215W CLG1 systematic mutation set Vegetative growth decreased rate 1 YGL236C MTO1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YGL236C MTO1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YLR125W systematic mutation set Vegetative growth decreased rate 1 YLR201C COQ9 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YLR201C COQ9 systematic mutation set Vegetative growth decreased rate 1 YLR203C MSS51 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YLR203C MSS51 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YLR203C MSS51 systematic mutation set Vegetative growth decreased rate 1 YML115C VAN1 systematic mutation set Vegetative growth decreased rate 1 YNL097C PHO23 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YNL097C PHO23 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YNL097C PHO23 systematic mutation set Vegetative growth decreased rate 1 YNL170W "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YNL170W "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YNL212W VID27 systematic mutation set Vegetative growth decreased rate 1 YNR041C COQ2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YNR041C COQ2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YNR041C COQ2 systematic mutation set Vegetative growth decreased rate 1 YNR052C POP2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 1 YNR052C POP2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 1 YNR052C POP2 systematic mutation set Vegetative growth decreased rate 1 YOL004W SIN3 systematic mutation set Vegetative growth decreased rate 1 YOL051W GAL11 systematic mutation set Vegetative growth decreased rate 1 YOR330C MIP1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YOR330C MIP1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YOR330C MIP1 systematic mutation set Vegetative growth decreased rate 1 YOR360C PDE2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YOR360C PDE2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YPR123C "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YPR123C "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 1 YDR123C INO2 systematic mutation set Lipid particle morphology abnormal 1 YBL051C PIN4 systematic mutation set Resistance to chemicals decreased nickel sulfate 1 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 1 YCL005W LDB16 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YCR004C YCP4 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased "2,4-Diacetylphloroglucinol" 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YEL053C MAK10 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased "2,4-Diacetylphloroglucinol" 1 YFL025C BST1 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YDR455C systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 1 YDR455C systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 1 YDR456W NHX1 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 1 YDR456W NHX1 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 1 YDR456W NHX1 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 1 YGL236C MTO1 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YJL162C JJJ2 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 1 YLR032W RAD5 classical genetics Resistance to chemicals decreased methyl methanesulfonate (0.01%) 1 YLR201C COQ9 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 1 YLR203C MSS51 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 1 YML097C VPS9 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 1 YML097C VPS9 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YML115C VAN1 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YNL041C COG6 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 1 YNL041C COG6 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 1 YNL097C PHO23 systematic mutation set Mutation frequency decreased 1 YNR041C COQ2 systematic mutation set Resistance to chemicals decreased "2,4-Diacetylphloroglucinol" 1 YNR052C POP2 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 1 YNR052C POP2 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 1 YNR052C POP2 systematic mutation set Metal resistance decreased nickel(2+) (3 mM NiCl2) 1 YNR052C POP2 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased nickel sulfate 1 YOL004W SIN3 systematic mutation set Mutation frequency decreased 1 YOR132W VPS17 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 1 YOR330C MIP1 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 1 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased nickel sulfate 1 YPR199C ARR1 classical genetics Resistance to chemicals decreased arsenate ion (As(V) 2 mM) 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased methanol (16%) 1 YKL190W CNB1 classical genetics Resistance to chemicals decreased cadmium chloride 1 YFL031W HAC1 classical genetics Resistance to chemicals decreased "1,4-dithiothreitol (10 mM)" 1 YFL031W HAC1 classical genetics Resistance to chemicals decreased cadmium chloride (50 uM) 1 YFL031W HAC1 classical genetics Resistance to chemicals decreased tunicamycin (1 ug/ml) 1 YGL147C RPL9A competitive growth Competitive fitness decreased 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased ethanol (10%) 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 1 YBR255W MTC4 competitive growth Vegetative growth decreased rate 1 YGL147C RPL9A competitive growth Vegetative growth decreased rate 1 YCL014W BUD3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 1 YMR183C SSO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 1 YNR052C POP2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Acid pH resistance decreased pH 4.5 1 YOL051W GAL11 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 1 YCR088W ABP1 classical genetics Protein/peptide distribution abnormal localization to actin cortical patch is absent and Inp52p becomes diffuse and cytoplasmic Inp52p-delta37C-GFP 1 YEL053C MAK10 classical genetics Mitophagy decreased mitophagy defects observed using three different assays in either S288C or SEY6210 background 1 YNL076W MKS1 systematic mutation set Invasive growth absent 1 YNL097C PHO23 systematic mutation set Invasive growth absent 1 YOR360C PDE2 systematic mutation set Invasive growth absent 1 YNL076W MKS1 classical genetics Resistance to chemicals decreased rapamycin (40 ng/ml) 1 YNL076W MKS1 systematic mutation set Filamentous growth decreased greatly decreased 1 YNL097C PHO23 systematic mutation set Filamentous growth decreased greatly decreased 1 YOR360C PDE2 systematic mutation set Filamentous growth decreased 1 YNL076W MKS1 classical genetics Protein/peptide modification abnormal Rtg3p 1 YLR201C COQ9 classical genetics Respiratory growth absent growth defect on nonfermentable carbon sources (growth can be rescued by addition of 2 microM Coenzyme Q6) 1 YLR203C MSS51 classical genetics Protein/peptide accumulation absent Cox1p 1 YNR041C COQ2 classical genetics Respiratory growth absent ethanol;glycerol 1 YBL051C PIN4 classical genetics Resistance to chemicals decreased bleomycin A2 1 YBR231C SWC5 classical genetics Resistance to chemicals decreased hydroxyurea 1 YCL061C MRC1 classical genetics Resistance to chemicals decreased benomyl (12.5 ug/ml) 1 YCL061C MRC1 classical genetics Resistance to chemicals decreased hydroxyurea (40 mM) 1 YDR456W NHX1 classical genetics Resistance to chemicals decreased hygromycin B (30 micrograms/ml) 1 YGL236C MTO1 classical genetics RNA accumulation decreased steady-state accumulation of different mitochondrial tRNA species differs mt tRNA 1 YLR203C MSS51 classical genetics Autophagy decreased amino acid starvation with acetate (non-fermentable) carbon source autophagic flux measured by the ratio of free GFP (resulting from autophagic degradation of Atg8p-GFP fusion) to total GFP 1 YNL041C COG6 systematic mutation set Resistance to chemicals decreased amiodarone (7 uM) 1 YNL097C PHO23 classical genetics Resistance to chemicals decreased camptothecin 1 YNR041C COQ2 classical genetics Resistance to chemicals decreased linoleic acid (82 mM) reduced viability after treatment with linoleic acid for 4 hr 1 YOR360C PDE2 classical genetics Hyperosmotic stress resistance decreased sodium chloride (1 M) elevated temperature (37 deg C) 1 YOR360C PDE2 classical genetics Oxidative stress resistance decreased hydrogen peroxide (1.5 mM) elevated temperature (37 deg C) 1 YPR199C ARR1 classical genetics Resistance to chemicals decreased potassium antimonyl tartrate (1.0 mM) slight sensitivity; similar results in S288C background; MIC 10.0 1 YPR199C ARR1 classical genetics Resistance to chemicals decreased sodium arsenate (0.25 mM) similar results in S288C background; MIC 1.0 mM 1 YPR199C ARR1 classical genetics Resistance to chemicals decreased sodium arsenite (0.05 mM) similar results in S288C background; MIC 0.2 mM 1 YOL059W GPD2 classical genetics Anaerobic growth decreased rate defined minimal medium 1 YCL005W LDB16 systematic mutation set Resistance to chemicals decreased nickel(2+) 1 YCR034W FEN1 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 1 YDR455C systematic mutation set Resistance to chemicals decreased gentamycin C1 (256 micrograms/ml) 1 YGL236C MTO1 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 1 YJL201W ECM25 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 1 YML097C VPS9 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 1 YNL097C PHO23 classical genetics Resistance to chemicals decreased cycloheximide (0.32 ug/ml) 1 YNR052C POP2 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased calcofluor white (50 ug/ml) 1 YOL004W SIN3 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 1 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased calcofluor white (50 ug/ml) 1 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 1 YPR199C ARR1 classical genetics Resistance to chemicals decreased sodium arsenate 1 YPR199C ARR1 classical genetics Resistance to chemicals decreased sodium metaarsenite (1-5 mM) 2 YAL040C CLN3 classical genetics Chromosome/plasmid maintenance abnormal details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype;a-like faker (ALF) assay 2 YBR126C TPS1 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YBR156C SLI15 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;increased frequency of mitotic chromosome loss 2 YBR156C SLI15 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YBR189W RPS9B classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YBR189W RPS9B homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at the SAM2 locus increased 6-20 fold, at MET15 increased 2-6 fold, but not changed at MAT" 2 YBR194W AIM4 large-scale survey Mitochondrial genome maintenance abnormal decreased frequency of spontaneous mitochondrial genome loss 2 YBR194W AIM4 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YBR200W BEM1 classical genetics Vacuolar morphology abnormal 2 YBR278W DPB3 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at the MET15 locus increased 6-20 fold, and at MAT and SAM2 increased 2-6 fold" 2 YCL008C STP22 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YCL008C STP22 classical genetics Vacuolar morphology abnormal 2 YCR009C RVS161 classical genetics Protein/peptide distribution abnormal accumulates in the Golgi in addition to the plasma membrane Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YCR009C RVS161 homozygous diploid Filamentous growth abnormal hydroxyurea (100 mM) HU-induced filamentous growth 2 YCR009C RVS161 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; moderate defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Protein/peptide distribution abnormal Can1p-GFP (A marker for MCC (membrane compartment of Can1) cortical patch formation) 2 YCR009C RVS161 systematic mutation set Protein/peptide distribution abnormal "type I and II mutants display a dot-like intracellular localization, exaggerated vacuolar labeling, and reduced plasma membrane labeling" Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YCR084C TUP1 homozygous diploid Protein/peptide distribution abnormal weak signal localizes to polarized sites in less than 10% of cells Bud8p-GFP 2 YCR084C TUP1 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; moderate defect 2 YCR084C TUP1 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YEL061C CIN8 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;indicative of chromosome instability (CIN); high confidence set; 4-fold increase over wildtype 2 YER087W AIM10 large-scale survey Mitochondrial genome maintenance abnormal decreased frequency of spontaneous mitochondrial genome loss 2 YER087W AIM10 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YHL019C APM2 classical genetics Vacuolar transport abnormal GFP-Cps1p 2 YHL019C APM2 classical genetics Vacuolar transport abnormal GFP-Phm5p 2 YHR021C RPS27B "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; weak defect 2 YHR021C RPS27B "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YHR021C RPS27B systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YHR031C RRM3 classical genetics Chromosome/plasmid maintenance abnormal defective telomere localization to the nuclear periphery (during both G1 and S phases) 2 YHR031C RRM3 classical genetics Chromosome/plasmid maintenance abnormal details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype;a-like faker (ALF) assay 2 YHR031C RRM3 classical genetics Protein/peptide distribution abnormal no obvious foci; diffused fluorescence in the entire nucleus GFP-Rap1 2 YHR031C RRM3 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;indicative of chromosome instability (CIN); high confidence set; >= 5-fold increase over wildtype 2 YHR031C RRM3 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at the MET15 and MAT loci increased 20-fold or greater, and at SAM2 increased 6-20 fold" 2 YHR031C RRM3 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YHR038W RRF1 systematic mutation set Mitochondrial morphology abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology 2 YHR041C SRB2 classical genetics Subcellular morphology abnormal increased T-body formation 2 YHR059W FYV4 large-scale survey Mitochondrial genome maintenance abnormal decreased frequency of spontaneous mitochondrial genome loss 2 YHR129C ARP1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YHR154W RTT107 classical genetics Bud morphology abnormal large bud with elongated nucleus 2 YHR154W RTT107 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 2 YHR154W RTT107 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;indicative of chromosome instability (CIN); high confidence set; 4-fold increase over wildtype 2 YIL073C SPO22 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YIL153W RRD1 classical genetics Protein/peptide modification abnormal rapamycin (200 ng/ml) Stp1p 2 YIL157C COA1 large-scale survey Mitochondrial genome maintenance abnormal increased frequency of spontaneous mitochondrial genome loss 2 YKL037W AIM26 large-scale survey Mitochondrial genome maintenance abnormal increased frequency of spontaneous mitochondrial genome loss 2 YKL037W AIM26 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YKL113C RAD27 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 2 YKL113C RAD27 classical genetics Chromosome/plasmid maintenance abnormal gross chromosomal rearrangements increased by at least 10-fold relative to wildtype 2 YKL113C RAD27 classical genetics Protein/peptide distribution abnormal no obvious foci; diffused fluorescence in the entire nucleus GFP-Rap1 2 YKL113C RAD27 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;indicative of chromosome instability (CIN); high confidence set; 4-fold increase over wildtype 2 YKL113C RAD27 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at MET15, SAM2 and MAT loci increased 20-fold or greater" 2 YKL113C RAD27 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YKR085C MRPL20 systematic mutation set Mitochondrial morphology abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology 2 YDL056W MBP1 systematic mutation set Mitochondrial morphology abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology 2 YDL106C PHO2 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YDL133W SRF1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YDL231C BRE4 classical genetics Protein/peptide distribution abnormal increased amounts of Ccw14p in culture supernatant Ccw14p 2 YDL231C BRE4 classical genetics Protein/peptide distribution abnormal increased amounts of Cwp1p in culture supernatant Cwp1p 2 YDL231C BRE4 classical genetics Protein/peptide distribution abnormal Hsp150p 2 YDR159W SAC3 large-scale survey RNA accumulation abnormal "HSP104 RNA (After heast shock, HSP104 RNA accumulated in nuclear foci instead of being exported as in wildtype)" 2 YDR159W SAC3 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YDR174W HMO1 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YDR174W HMO1 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YDR174W HMO1 systematic mutation set Lipid particle morphology abnormal fewer lipid droplets with abnormal morphology 2 YDR207C UME6 homozygous diploid Lipid particle morphology abnormal lipid droplet shell exaggerated and thicker; increased number of droplets per cell 2 YDR207C UME6 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YDR264C AKR1 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YDR264C AKR1 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YDR264C AKR1 systematic mutation set Protein/peptide distribution abnormal type I mutants display a dot-like intracellular localization in addition to plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YDR293C SSD1 classical genetics Protein/peptide distribution abnormal "pretreatment at 37 deg C for 30 min, then heat shock at 46 deg C for 30 min" punctate distribution of Hsp104p rather than diffuse distribution as in wild type Hsp104p 2 YDR293C SSD1 systematic mutation set Lipid particle morphology abnormal fewer lipid droplets with abnormal morphology 2 YDR293C SSD1 systematic mutation set Lipid particle morphology abnormal 2 YDR293C SSD1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YDR320C SWA2 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; weak defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Budding pattern abnormal 50% of cells exhibited random budding pattern 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Protein/peptide distribution abnormal Can1p-GFP (A marker for MCC (membrane compartment of Can1) cortical patch formation) 2 YDR378C LSM6 homozygous diploid Chromosome/plasmid maintenance abnormal increased frequency of mitotic chromosome loss;diploid bimater (BiM) assay 2 YDR378C LSM6 homozygous diploid Chromosome/plasmid maintenance abnormal indicative of chromosome instability (CIN); high confidence set; 2-fold increase over wildtype;diploid bimater (BiM) assay 2 YDR378C LSM6 "homozygous diploid, systematic mutation set" Budding pattern abnormal unipolar budding pattern 2 YDR432W NPL3 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YDR432W NPL3 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YGL025C PGD1 classical genetics Chromosome/plasmid maintenance abnormal defective telomere localization to the nuclear periphery (during both G1 and S phases) 2 YGL025C PGD1 classical genetics Protein/peptide distribution abnormal no obvious foci; diffused fluorescence in the entire nucleus GFP-Rap1 2 YGL025C PGD1 systematic mutation set Protein/peptide distribution abnormal type II mutants exhibit exaggerated vacuolar and reduced plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YGL066W SGF73 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YGL086W MAD1 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;indicative of chromosome instability (CIN); high confidence set; >= 5-fold increase over wildtype 2 YGL143C MRF1 systematic mutation set Mitochondrial morphology abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology 2 YGL148W ARO2 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YGL148W ARO2 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YGL167C PMR1 classical genetics Vacuolar morphology abnormal multiple lobes or fragmented compartments reversed by addition of amiodarone or CaCl2 2 YGL223C COG1 "homozygous diploid, systematic mutation set" Protein/peptide distribution abnormal Can1p-GFP (A marker for MCC (membrane compartment of Can1) cortical patch formation) 2 YGL223C COG1 systematic mutation set Bud morphology abnormal bud is abnormally round 2 YGL246C RAI1 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; weak defect 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YGR163W GTR2 classical genetics Protein/peptide distribution abnormal "localizes to intracellular membranes, rather than the plasma membrane" Gap1p 2 YGR252W GCN5 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YGR252W GCN5 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YJL053W PEP8 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YJL053W PEP8 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YJL073W JEM1 systematic mutation set Protein/peptide distribution abnormal type I mutants display a dot-like intracellular localization in addition to plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YJL073W JEM1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YJL141C YAK1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YJL154C VPS35 systematic mutation set Lipid particle morphology abnormal 2 YJL154C VPS35 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YJL188C BUD19 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; moderate defect 2 YJL188C BUD19 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YJR032W CPR7 large-scale survey Mitochondrial genome maintenance abnormal decreased frequency of spontaneous mitochondrial genome loss 2 YJR033C RAV1 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YJR102C VPS25 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YJR118C ILM1 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YJR118C ILM1 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; moderate defect 2 YJR118C ILM1 "homozygous diploid, systematic mutation set" Budding pattern abnormal 50% of cells exhibited random budding pattern 2 YJR118C ILM1 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YJR118C ILM1 systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 2 YLL002W RTT109 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 2 YLL002W RTT109 classical genetics Chromosome/plasmid maintenance abnormal decreased stability of repetitive DNA 2 YLL002W RTT109 classical genetics Chromosome/plasmid maintenance abnormal defective telomere localization to the nuclear periphery (during both G1 and S phases) 2 YLL002W RTT109 homozygous diploid Chromosome/plasmid maintenance abnormal indicative of chromosome instability (CIN); high confidence set; 2-fold increase over wildtype;diploid bimater (BiM) assay 2 YLL002W RTT109 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at MET15, SAM2 and MAT loci increased 20-fold or greater" 2 YLR025W SNF7 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YLR039C RIC1 classical genetics Protein/peptide distribution abnormal "Arl1p-GFP (diffuse, homogeneous staining of cytoplasm compared with normal punctate staining of Golgi)" 2 YLR039C RIC1 classical genetics Protein/peptide distribution abnormal Imh1p-GFP (exhibits diffuse cytoplamic pattern rather than Golgi localization) 2 YLR039C RIC1 classical genetics Protein/peptide distribution abnormal Sys1p-GFP (granular distribution within cytoplasm compared with normal punctate staining of Golgi) 2 YLR039C RIC1 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YLR226W BUR2 classical genetics Chromosome/plasmid maintenance abnormal increased frequency of gross chromosomal rearrangements (chromosomal instability is due to the accumulation of RNA-DNA hybrids that can cause DSBs) 2 YLR226W BUR2 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YLR226W BUR2 systematic mutation set Lipid particle morphology abnormal 2 YLR322W VPS65 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YLR370C ARC18 classical genetics Actin cytoskeleton morphology abnormal actin patches fail to localize preferentially to growing buds 2 YLR370C ARC18 classical genetics Mitochondrial morphology abnormal decreased anterograde mitochondrial movement 2 YLR370C ARC18 homozygous diploid Chromosome/plasmid maintenance abnormal increased frequency of mitotic chromosome loss;diploid bimater (BiM) assay 2 YLR370C ARC18 systematic mutation set Bud morphology abnormal bud is abnormally round 2 YLR396C VPS33 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YLR396C VPS33 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YLR417W VPS36 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YMR077C VPS20 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YMR077C VPS20 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YMR091C NPL6 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YMR097C MTG1 systematic mutation set Mitochondrial morphology abnormal morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology 2 YMR152W YIM1 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YMR179W SPT21 classical genetics Chromosome/plasmid maintenance abnormal details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype;a-like faker (ALF) assay 2 YMR179W SPT21 classical genetics Subcellular morphology abnormal increased T-body formation 2 YMR179W SPT21 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;increased frequency of mitotic chromosome loss 2 YMR179W SPT21 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;indicative of chromosome instability (CIN); high confidence set; >= 5-fold increase over wildtype 2 YMR179W SPT21 large-scale survey Subcellular morphology abnormal increased T-body formation 2 YMR179W SPT21 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YMR179W SPT21 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YMR205C PFK2 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YMR205C PFK2 systematic mutation set Protein/peptide distribution abnormal "type I and II mutants display a dot-like intracellular localization, exaggerated vacuolar labeling, and reduced plasma membrane labeling" Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YMR307W GAS1 classical genetics Cell wall morphology abnormal "altered topography and elasticity of cell wall, as measured by atomic force microscopy" 2 YMR307W GAS1 homozygous diploid Protein/peptide distribution abnormal "localizes to polarized sites in 17% of cells, and not detectable in the remainder" Bud8p-GFP 2 YMR307W GAS1 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; moderate defect 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YMR307W GAS1 systematic mutation set Bud morphology abnormal bud is abnormally round 2 YNL055C POR1 systematic mutation set Mitochondrial morphology abnormal mutant is respiratory competent;morphology is somewhat affected; a fraction of cells exhibit wild-type mitochondrial morphology 2 YNL059C ARP5 classical genetics Protein/peptide distribution abnormal Nop1p (localization of GFP-Nop1p) 2 YNL059C ARP5 classical genetics Protein/peptide distribution abnormal Nup49p (localization of GFP-Nup49p) 2 YNL059C ARP5 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YNL059C ARP5 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YNL084C END3 "homozygous diploid, large-scale survey" Cell shape abnormal round cell shape; weak defect 2 YNL084C END3 "homozygous diploid, systematic mutation set" Budding pattern abnormal >50% of cells exhibited random budding pattern 2 YNL084C END3 systematic mutation set Protein/peptide distribution abnormal type I mutants display a dot-like intracellular localization in addition to plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YNL107W YAF9 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;increased frequency of mitotic chromosome loss 2 YNL107W YAF9 systematic mutation set Bud morphology abnormal bud is abnormally elongated 2 YNL107W YAF9 systematic mutation set Protein transport abnormal Kar2p is secreted rather than retained in the ER 2 YNL199C GCR2 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YNL250W RAD50 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 2 YNL250W RAD50 homozygous diploid Chromosome/plasmid maintenance abnormal indicative of chromosome instability (CIN); high confidence set; 4-fold increase over wildtype;diploid bimater (BiM) assay 2 YNL250W RAD50 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at MET15, SAM2 and MAT loci increased 20-fold or greater" 2 YNL297C MON2 classical genetics Protein/peptide distribution abnormal depleted from the plasma membrane and accumulates on internal membranes; similar results seen with Sso1p GFP-Snc1p 2 YNL297C MON2 classical genetics Protein/peptide distribution abnormal majority of cells shows a diffuse cytoplasmic localization compared to late Golgi localization observed in wildtype cells GFP-Dop1p 2 YOR069W VPS5 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YOR069W VPS5 systematic mutation set Protein/peptide distribution abnormal vacuolar staining is absent but delivery to the plasma membrane is normal or enhanced Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YOR290C SNF2 classical genetics Subcellular morphology abnormal decreased T-body formation 2 YOR290C SNF2 systematic mutation set Protein/peptide distribution abnormal type II mutants exhibit exaggerated vacuolar and reduced plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YPL002C SNF8 classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YPL017C IRC15 classical genetics Chromosome/plasmid maintenance abnormal a-like faker (ALF) assay;details: indicative of chromosome instability (CIN); high confidence set; 2- to 80-fold increase relative to wildtype 2 YPL017C IRC15 homozygous diploid Chromosome/plasmid maintenance abnormal diploid bimater (BiM) assay;increased frequency of mitotic chromosome loss 2 YPL051W ARL3 classical genetics Protein/peptide distribution abnormal Imh1p-GFP (exhibits diffuse cytoplamic pattern rather than Golgi localization) 2 YPL051W ARL3 classical genetics Vacuolar morphology abnormal vacuole fragmentation increased 2 YPL073C classical genetics Protein/peptide distribution abnormal Ptr2p-GFP 2 YPL180W TCO89 systematic mutation set Chemical compound accumulation abnormal polyphosphate 2 YPL180W TCO89 systematic mutation set Vegetative growth abnormal decreased growth rate of newly germinated spores 2 YPR047W MSF1 homozygous diploid Chromosome/plasmid maintenance abnormal "loss of heterozygosity at the MET15 locus increased 2-6 fold, but not changed at MAT or SAM2 loci" 2 YPR123C systematic mutation set Protein/peptide distribution abnormal type I mutants display a dot-like intracellular localization in addition to plasma membrane labeling Fus-Mid-GFP (extracellular O-glycosylated region of Fus1p fused to the transmembrane domain and cytoplasmic tail of Mid2p) 2 YMR307W GAS1 classical genetics Cell shape abnormal very round cells 2 YMR307W GAS1 classical genetics Vacuolar morphology abnormal 2 YOL108C INO4 systematic mutation set Lipid particle morphology abnormal 2 YLR181C VTA1 classical genetics Protein/peptide distribution abnormal equally distributed between membrane and soluble fractions Snf7p 2 YLR181C VTA1 classical genetics Vacuolar transport abnormal "partial defect; some CPS accumulates in the lumen and some in the limiting membrane of the vacuole, but none in the class E compartment" carboxypeptidase S 2 YLR181C VTA1 classical genetics Vacuolar transport abnormal "partial defect; some CPS accumulates in the lumen and some in the limiting membrane of the vacuole, but none in the class E compartment" carboxypeptidase S 2 YBR200W BEM1 classical genetics Cell shape abnormal butan-1-ol (1%) alcohol-induced cell elongation is absent 2 YCR009C RVS161 homozygous diploid Cell shape abnormal hydroxyurea (100 mM) HU-induced filamentous growth chains of round or oval cells indicating defects in cell elongation 2 YCR009C RVS161 homozygous diploid Filamentous growth abnormal hydroxyurea (100 mM) HU-induced filamentous growth 2 YHR124W NDT80 homozygous diploid Meiotic recombination abnormal 2-3 fold elevation of commitment to heteroallelic recombination and a 2-fold decrease in crossovers 2 YIL073C SPO22 "homozygous diploid, systematic mutation set" Meiosis abnormal Aberrant meiotic chromosome segregation 2 YGL167C PMR1 homozygous diploid Meiosis abnormal many asci contain more than four spores 2 YEL061C CIN8 classical genetics Spindle morphology abnormal spindle length shorter in both metaphase and anaphase 2 YDR174W HMO1 classical genetics Chromosome/plasmid maintenance abnormal increased rate of plasmid loss 2 YGL066W SGF73 homozygous diploid Meiosis abnormal efficiency of nuclear division during meiosis is decreased 2 YGR252W GCN5 classical genetics Spindle morphology abnormal short spindles (delayed elongation in metaphase) 2 YJL141C YAK1 classical genetics Protein/peptide distribution abnormal ethanol grown cells cytoplasmic levels are reduced while nuclear levels are increased GFP-HA-Bcy1p 2 YNL076W MKS1 classical genetics Protein/peptide modification abnormal Rtg3p 2 YPL017C IRC15 homozygous diploid Meiosis abnormal increased meiotic chromosome missegregation 2 YEL061C CIN8 classical genetics Chromosome segregation abnormal cincreasin (120 micromolar) 2 YGL086W MAD1 classical genetics Chromosome/plasmid maintenance abnormal cincreasin (60 uM) 2 YLR417W VPS36 classical genetics Vacuolar transport abnormal 2 YMR307W GAS1 classical genetics Pheromone sensitivity abnormal 2 YAL013W DEP1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Respiratory growth absent glycerol 2 YBR289W SNF5 systematic mutation set Respiratory growth absent glycerol carbon source 2 YBR289W SNF5 systematic mutation set Respiratory growth absent glycerol carbon source 2 YCL008C STP22 classical genetics Protein/peptide modification absent carboxypeptidase Y (Prc1p) 2 YCL008C STP22 classical genetics Protein secretion absent starvation conditions Acb1p 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Sporulation absent 2 YCR009C RVS161 systematic mutation set Respiratory growth absent glycerol carbon source 2 YCR084C TUP1 "homozygous diploid, systematic mutation set" Sporulation absent 2 YCR084C TUP1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YER078C ICP55 classical genetics Protein/peptide modification absent Mge1p and other specific mitochondrially-tageted proteins are not processed to the mature form Mge1p 2 YER078C ICP55 classical genetics Respiratory growth absent glycerol nonfermentable carbon source at elevated temperature (37 deg C) 2 YER087W AIM10 systematic mutation set Respiratory growth absent glycerol carbon source 2 YER087W AIM10 systematic mutation set Respiratory growth absent glycerol carbon source 2 YHR038W RRF1 large-scale survey Respiratory growth absent nonfermentable carbon source (2% glycerol) 2 YHR038W RRF1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YHR038W RRF1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YHR039C MSC7 systematic mutation set Respiratory growth absent glycerol carbon source 2 YHR059W FYV4 systematic mutation set Respiratory growth absent glycerol carbon source 2 YHR124W NDT80 "homozygous diploid, systematic mutation set" Sporulation absent 2 YHR178W STB5 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 2 YIL157C COA1 large-scale survey Respiratory growth absent nonfermentable carbon source (2% glycerol) 2 YIL157C COA1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YKR085C MRPL20 systematic mutation set Respiratory growth absent glycerol carbon source 2 YKR085C MRPL20 systematic mutation set Respiratory growth absent glycerol carbon source 2 YDL056W MBP1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YDL056W MBP1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YDL133W SRF1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YDR149C "homozygous diploid, large-scale survey" Vegetative growth absent anaerobic conditions (YPD plus ergosterol and Tween-80 in the absence of O2) 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Sporulation absent 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Respiratory growth absent glycerol 2 YDR268W MSW1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL025C PGD1 "homozygous diploid, large-scale survey" Vegetative growth absent anaerobic conditions (YPD plus ergosterol and Tween-80 in the absence of O2) 2 YGL066W SGF73 "homozygous diploid, systematic mutation set" Sporulation absent 2 YGL071W AFT1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL071W AFT1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL135W RPL1B systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL135W RPL1B systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL143C MRF1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL143C MRF1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL148W ARO2 systematic mutation set Mitophagy absent growth on lactate carbon source to post-log phase 2 YGL148W ARO2 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 2 YGL167C PMR1 systematic mutation set Mitophagy absent growth on lactate carbon source to post-log phase 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Sporulation absent 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Sporulation absent 2 YJR139C HOM6 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 2 YLR025W SNF7 classical genetics Utilization of carbon source absent raffinose 2 YLR226W BUR2 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 2 YLR322W VPS65 "homozygous diploid, large-scale survey" Vegetative growth absent anaerobic conditions (YPD plus ergosterol and Tween-80 in the absence of O2) 2 YLR322W VPS65 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Respiratory growth absent glycerol 2 YLR396C VPS33 systematic mutation set Respiratory growth absent glycerol carbon source 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Respiratory growth absent glycerol 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Sporulation absent 2 YMR077C VPS20 systematic mutation set Respiratory growth absent glycerol carbon source 2 YMR091C NPL6 systematic mutation set Utilization of nitrogen source absent allantoin "cultured in minimal medium containing histidine, leucine, lysine and uracil" 2 YMR097C MTG1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YMR097C MTG1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YMR098C ATP25 large-scale survey Respiratory growth absent nonfermentable carbon source (2% glycerol) 2 YMR098C ATP25 systematic mutation set Respiratory growth absent glycerol carbon source 2 YMR098C ATP25 systematic mutation set Respiratory growth absent glycerol carbon source 2 YNL296W "homozygous diploid, systematic mutation set" Sporulation absent 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Sporulation absent 2 YOR290C SNF2 systematic mutation set Respiratory growth absent glycerol carbon source 2 YPL002C SNF8 classical genetics Utilization of carbon source absent galactose 2 YPL002C SNF8 classical genetics Utilization of carbon source absent raffinose 2 YPL002C SNF8 classical genetics Utilization of carbon source absent raffinose 2 YPL029W SUV3 systematic mutation set Respiratory growth absent glycerol carbon source 2 YPL069C BTS1 "homozygous diploid, large-scale survey" Vegetative growth absent anaerobic conditions (YPD plus ergosterol and Tween-80 in the absence of O2) 2 YPL173W MRPL40 systematic mutation set Respiratory growth absent glycerol carbon source 2 YPL173W MRPL40 systematic mutation set Respiratory growth absent glycerol carbon source 2 YPR047W MSF1 systematic mutation set Respiratory growth absent glycerol carbon source 2 YPR123C systematic mutation set Respiratory growth absent glycerol carbon source 2 YGL148W ARO2 classical genetics Mitophagy absent mitophagy not detected using three different assays in either S288C or SEY6210 background 2 YBR200W BEM1 homozygous diploid Pseudohyphal growth absent 2 YIL157C COA1 large-scale survey Utilization of carbon source absent glycerol 2 YIL157C COA1 systematic mutation set Invasive growth absent 2 YKL113C RAD27 systematic mutation set Invasive growth absent 2 YKR010C TOF2 systematic mutation set Invasive growth absent 2 YDR268W MSW1 large-scale survey Utilization of carbon source absent glycerol 2 YDR268W MSW1 systematic mutation set Invasive growth absent 2 YJR102C VPS25 classical genetics Invasive growth absent 2 YML121W GTR1 systematic mutation set Invasive growth absent 2 YMR077C VPS20 classical genetics Invasive growth absent 2 YMR152W YIM1 systematic mutation set Invasive growth absent 2 YNL076W MKS1 systematic mutation set Invasive growth absent 2 YOR360C PDE2 systematic mutation set Invasive growth absent 2 YPL029W SUV3 large-scale survey Utilization of carbon source absent glycerol 2 YPL029W SUV3 systematic mutation set Invasive growth absent 2 YPL057C SUR1 systematic mutation set Invasive growth absent 2 YHR124W NDT80 homozygous diploid Sporulation absent 2 YDR268W MSW1 classical genetics Respiratory growth absent glycerol 2 YDR268W MSW1 classical genetics Respiratory growth absent nonfermentable carbon source (glycerol) 2 YGL143C MRF1 classical genetics Respiratory growth absent ethanol (2%);glycerol (2%) 2 YMR098C ATP25 classical genetics Respiratory growth absent ethanol;glycerol defect is complemented by co-expression of the N- and C-terminal halves of Atp25p 2 YPR047W MSF1 classical genetics Respiratory growth absent nonfermentable carbon source (glycerol) 2 YLR396C VPS33 homozygous diploid Sporulation absent 2 YLR025W SNF7 classical genetics Utilization of carbon source absent Antimycin A (1 microgram/ml);raffinose (2%) anaerobic growth 2 YLR025W SNF7 homozygous diploid Sporulation absent 2 YMR097C MTG1 classical genetics Respiratory growth absent 2 YHR124W NDT80 homozygous diploid Meiosis arrested majority of intact nuclei in pachytene-arrested mutants display paired chromosomes and large polycomplexes with few synaptonemal complexes (contrasts with chromosomal spreads) 2 YHR124W NDT80 homozygous diploid Meiosis arrested "pachytene arrest with full-length synaptonemal complexes, duplicated but unseparated SPBs, and polycomplex accumulation" 2 YAL013W DEP1 classical genetics Resistance to chemicals decreased cycloheximide (0.10 ug/ml) 2 YAL013W DEP1 competitive growth Competitive fitness decreased minimal medium 2 YAL013W DEP1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YAL013W DEP1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YAL013W DEP1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YAL013W DEP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YAL013W DEP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YAL013W DEP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YAL013W DEP1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YAL013W DEP1 systematic mutation set Chitin deposition decreased 2 YAL013W DEP1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YAL013W DEP1 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 2 YAL013W DEP1 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YAL013W DEP1 systematic mutation set Resistance to chemicals decreased wortmannin 2 YAL013W DEP1 systematic mutation set Telomere length decreased 2 YAL013W DEP1 systematic mutation set Transposable element transposition decreased Ty3 2 YAL030W SNC1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YAL030W SNC1 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YAL040C CLN3 competitive growth Competitive fitness decreased minimal medium 2 YAL040C CLN3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YAL040C CLN3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YAL040C CLN3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YAL040C CLN3 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YAL040C CLN3 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YAL040C CLN3 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YAL040C CLN3 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YBL065W competitive growth Competitive fitness decreased minimal medium 2 YBL065W "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "weak sensitivity, one relative fitness ratio below 0.92" 2 YBL065W systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YBL065W systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete medium) 2 YBL065W systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - thr medium) 2 YBL081W competitive growth Competitive fitness decreased minimal medium 2 YBR036C CSG2 classical genetics Resistance to chemicals decreased duramycin 2 YBR036C CSG2 competitive growth Competitive fitness decreased minimal medium 2 YBR036C CSG2 homozygous diploid Chemical compound accumulation decreased lithium(1+) cells treated with 0.2 M LiCl intracellular content 2-3 times greater than the wild-type control 2 YBR036C CSG2 "homozygous diploid, systematic mutation set" Acid pH resistance decreased strong growth defect;pH 3.0 2 YBR036C CSG2 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.2 M LiCl) 2 YBR036C CSG2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YBR036C CSG2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YBR036C CSG2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YBR036C CSG2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YBR036C CSG2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YBR036C CSG2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YBR036C CSG2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased acetaldehyde (35 mM) 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased PM02734 (250 ug/ml; synthetic cyclic depsipeptide related to natural kahalalides) 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) moderate sensitivity 2 YBR126C TPS1 classical genetics Chemical compound accumulation decreased trehalose "pretreatment at 37 deg C for 30 min, then heat shock at 46 deg C for 30 min" 2 YBR126C TPS1 competitive growth Competitive fitness decreased minimal medium 2 YBR126C TPS1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR126C TPS1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YBR126C TPS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YBR126C TPS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YBR126C TPS1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YBR126C TPS1 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;partial growth inhibition on exposure to 66% zymocin; not inhibited by 33% zymocin 2 YBR126C TPS1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YBR126C TPS1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) moderate sensitivity 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased rapamycin 2 YBR156C SLI15 competitive growth Competitive fitness decreased minimal medium 2 YBR156C SLI15 "heterozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR156C SLI15 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR156C SLI15 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YBR156C SLI15 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YBR156C SLI15 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YBR170C NPL4 competitive growth Competitive fitness decreased minimal medium 2 YBR189W RPS9B competitive growth Competitive fitness decreased minimal medium 2 YBR189W RPS9B "heterozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR189W RPS9B "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR189W RPS9B "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YBR189W RPS9B "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.1 M LiCl) 2 YBR189W RPS9B large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YBR189W RPS9B large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YBR189W RPS9B large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YBR189W RPS9B systematic mutation set Nutrient utilization decreased His-Leu dipeptide "cultured in minimal medium containing histidine, lysine, uracil and tryptophan" decreased ability to utilize the His-Leu dipeptide resulting in poor growth relative to the wildtype control 2 YBR189W RPS9B systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YBR189W RPS9B systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YBR189W RPS9B systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 2 YBR194W AIM4 competitive growth Competitive fitness decreased minimal medium 2 YBR194W AIM4 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR194W AIM4 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YBR194W AIM4 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YBR194W AIM4 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YBR194W AIM4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YBR194W AIM4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YBR194W AIM4 systematic mutation set Oxidative stress resistance decreased tert-butyl hydroperoxide (t-BuOOH) 2 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased 4-nitroquinoline N-oxide 2 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type 2 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YBR194W AIM4 systematic mutation set UV resistance decreased UV irradiation (254 nm) 2 YBR200W BEM1 classical genetics Prion formation decreased [PSI+] 2 YBR200W BEM1 classical genetics Resistance to chemicals decreased 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (40 uM) 2 YBR200W BEM1 classical genetics Resistance to chemicals decreased FK506 2 YBR200W BEM1 competitive growth Competitive fitness decreased minimal medium 2 YBR200W BEM1 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YBR200W BEM1 homozygous diploid Resistance to chemicals decreased benomyl (10 ug/ml) 2 YBR200W BEM1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR200W BEM1 "homozygous diploid, large-scale survey" Budding index decreased 2 YBR200W BEM1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YBR200W BEM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YBR200W BEM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YBR200W BEM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YBR200W BEM1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 2 YBR200W BEM1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YBR200W BEM1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YBR200W BEM1 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere 2 YBR200W BEM1 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) fails to grow in 0.5 mM paraquat 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) weak sensitivity 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml or 4 ug/ml CTBT 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased FK506 (2 ug/ml) weak sensitivity 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) hypersensitive 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YBR278W DPB3 competitive growth Competitive fitness decreased minimal medium 2 YBR278W DPB3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR278W DPB3 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YBR278W DPB3 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YBR278W DPB3 systematic mutation set Resistance to chemicals decreased rapamycin 2 YBR278W DPB3 systematic mutation set Resistance to chemicals decreased wortmannin 2 YBR289W SNF5 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YBR289W SNF5 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YBR289W SNF5 classical genetics Resistance to chemicals decreased zymocin (45% (v/v)) 2 YBR289W SNF5 competitive growth Competitive fitness decreased minimal medium 2 YBR289W SNF5 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YBR289W SNF5 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YBR289W SNF5 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YBR289W SNF5 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 2 YBR289W SNF5 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YBR289W SNF5 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased leucascandrolide A analog 3 (5 nM) 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) weak sensitivity 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) moderate sensitivity 2 YBR289W SNF5 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) moderate sensitivity 2 YBR298C MAL31 classical genetics Metal resistance decreased cadmium(2+) 2 YBR298C MAL31 competitive growth Competitive fitness decreased minimal medium 2 YBR298C MAL31 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YBR298C MAL31 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YBR298C MAL31 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YBR298C MAL31 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YBR298C MAL31 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YBR298C MAL31 systematic mutation set Resistance to chemicals decreased rapamycin 2 YBR298C MAL31 systematic mutation set Resistance to chemicals decreased wortmannin 2 YBR298C MAL31 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YCL008C STP22 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YCL008C STP22 classical genetics Toxin resistance decreased Ala-Eth dipeptide (0.1-0.2 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YCL008C STP22 homozygous diploid Resistance to chemicals decreased BPS (100 uM bathophenanthrolinebisulfonic acid) 2 YCL008C STP22 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YCL008C STP22 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "weak sensitivity, one relative fitness ratio below 0.92" 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) moderate growth defect 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YCL008C STP22 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YCL008C STP22 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YCL008C STP22 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YCL008C STP22 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YCL008C STP22 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YCL008C STP22 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YCL008C STP22 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YCL008C STP22 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased dihydromotuporamine C 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) strong sensitivity 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) weak sensitivity 2 YCL008C STP22 systematic mutation set Telomere length decreased 2 YCL008C STP22 systematic mutation set Telomere length decreased 2 YCL008C STP22 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YCL055W KAR4 competitive growth Competitive fitness decreased minimal medium 2 YCL055W KAR4 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YCL055W KAR4 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YCL055W KAR4 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YCR009C RVS161 classical genetics Chemical compound accumulation decreased calcium(2+) cells treated with alpha factor decreased low-affinity Ca2+ influx 2 YCR009C RVS161 classical genetics Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 reporter" 2 YCR009C RVS161 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YCR009C RVS161 classical genetics RNA accumulation decreased cells treated with alpha factor mating pheromone induction of SLT2 abolished SLT2-LacZ 2 YCR009C RVS161 classical genetics Toxin resistance decreased alpha-synuclein 2 YCR009C RVS161 competitive growth Competitive fitness decreased minimal medium 2 YCR009C RVS161 homozygous diploid Chemical compound accumulation decreased lithium(1+) cells treated with 0.2 M LiCl intracellular content 2-3 times greater than the wild-type control 2 YCR009C RVS161 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YCR009C RVS161 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YCR009C RVS161 "homozygous diploid, competitive growth" UV resistance decreased "moderate sensitivity, two relative fitness ratios below 0.92" 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) strong growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) moderate growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) strong growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) moderate growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) moderate growth defect 2 YCR009C RVS161 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YCR009C RVS161 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YCR009C RVS161 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YCR009C RVS161 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YCR009C RVS161 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YCR009C RVS161 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YCR009C RVS161 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YCR009C RVS161 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) strong sensitivity 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased leucascandrolide A analog 3 (5 nM) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YCR009C RVS161 systematic mutation set Thermotolerance decreased "pretreatment at 37 deg C for 30 min, then heat shock at 50 deg C for 30 min" 2 YCR084C TUP1 "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased sodium arsenite (450 uM) 2 YCR084C TUP1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YCR084C TUP1 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YCR084C TUP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YCR084C TUP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YCR084C TUP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YCR084C TUP1 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 2 YCR084C TUP1 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YCR084C TUP1 systematic mutation set Resistance to chemicals decreased hygromycin B (slow growth at 25 ug/mL and 50 ug/mL) 2 YCR084C TUP1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YCR084C TUP1 systematic mutation set Resistance to chemicals decreased rapamycin 2 YCR084C TUP1 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YCR084C TUP1 systematic mutation set Resistance to chemicals decreased wortmannin 2 YCR084C TUP1 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YEL015W EDC3 competitive growth Competitive fitness decreased minimal medium 2 YEL061C CIN8 competitive growth Competitive fitness decreased minimal medium 2 YEL061C CIN8 "heterozygous diploid, competitive growth" Resistance to chemicals decreased St. John's Wort extract 2 YEL061C CIN8 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YEL061C CIN8 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YEL061C CIN8 large-scale survey Resistance to chemicals decreased benomyl 2 YEL061C CIN8 systematic mutation set Resistance to chemicals decreased rapamycin 2 YEL061C CIN8 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YEL061C CIN8 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YER078C ICP55 competitive growth Competitive fitness decreased minimal medium 2 YER087W AIM10 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YER087W AIM10 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YER087W AIM10 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YER087W AIM10 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YHL019C APM2 classical genetics Toxin resistance decreased "HD20Q (Huntingtin protein, exon1 containing 20 polyglutamine repeats)" 2 YHL019C APM2 competitive growth Competitive fitness decreased minimal medium 2 YHL019C APM2 "homozygous diploid, competitive growth" UV resistance decreased "moderate sensitivity, two relative fitness ratios below 0.92" 2 YHL019C APM2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YHL019C APM2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YHL019C APM2 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YHL019C APM2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YHL019C APM2 systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 2 YHR012W VPS29 classical genetics Viability decreased nitrogen starvation 2 YHR012W VPS29 competitive growth Competitive fitness decreased minimal medium 2 YHR012W VPS29 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 2 YHR012W VPS29 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YHR012W VPS29 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YHR012W VPS29 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased benomyl (15 ug/ml) moderate growth defect 2 YHR012W VPS29 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 500 mM KCl 2 YHR012W VPS29 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 2 YHR012W VPS29 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) moderate sensitivity 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased rapamycin 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YHR021C RPS27B classical genetics Osmotic stress resistance decreased sodium chloride (1.5 M) 2 YHR021C RPS27B classical genetics Resistance to chemicals decreased caffeine (20 mM) 2 YHR021C RPS27B classical genetics Resistance to chemicals decreased manganese(2+) (10mM) 2 YHR021C RPS27B classical genetics Resistance to chemicals decreased rapamycin (20 nM) 2 YHR021C RPS27B competitive growth Competitive fitness decreased minimal medium 2 YHR021C RPS27B "heterozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR021C RPS27B "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR021C RPS27B "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YHR021C RPS27B "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YHR021C RPS27B "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YHR021C RPS27B systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YHR021C RPS27B systematic mutation set Resistance to chemicals decreased dihydromotuporamine C 2 YHR021C RPS27B systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YHR031C RRM3 competitive growth Competitive fitness decreased minimal medium 2 YHR031C RRM3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR031C RRM3 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YHR031C RRM3 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YHR031C RRM3 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YHR031C RRM3 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YHR031C RRM3 systematic mutation set Protein/peptide accumulation decreased Hta1p-GFP 2 YHR031C RRM3 systematic mutation set Resistance to chemicals decreased rapamycin 2 YHR031C RRM3 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YHR038W RRF1 classical genetics Toxin resistance decreased "HD20Q (Huntingtin protein, exon1 containing 20 polyglutamine repeats)" 2 YHR038W RRF1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR038W RRF1 "homozygous diploid, competitive growth" UV resistance decreased "weak sensitivity, one relative fitness ratio below 0.92" 2 YHR038W RRF1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YHR038W RRF1 large-scale survey Metal resistance decreased copper(2+) sulfate (2.5 mM) strong phenotype 2 YHR038W RRF1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YHR038W RRF1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YHR038W RRF1 systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 2 YHR039C MSC7 competitive growth Competitive fitness decreased minimal medium 2 YHR039C MSC7 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YHR039C MSC7 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YHR041C SRB2 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YHR041C SRB2 classical genetics Vegetative growth decreased 30 deg C 2 YHR041C SRB2 competitive growth Competitive fitness decreased minimal medium 2 YHR041C SRB2 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YHR041C SRB2 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YHR041C SRB2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YHR041C SRB2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YHR041C SRB2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased acetaldehyde (35 mM) 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) sensitive relative to wildtype 2 YHR041C SRB2 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) weak sensitivity 2 YHR041C SRB2 systematic mutation set Telomere length decreased 2 YHR041C SRB2 systematic mutation set Telomere length decreased 2 YHR046C INM1 classical genetics Resistance to chemicals decreased acetic acid (50 mM) slightly increased lag time before mutant begins growing under acetic acid stress 2 YHR059W FYV4 competitive growth Competitive fitness decreased minimal medium 2 YHR059W FYV4 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YHR059W FYV4 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR059W FYV4 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) moderate growth defect 2 YHR059W FYV4 systematic mutation set Killer toxin resistance decreased 2 YHR059W FYV4 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YHR059W FYV4 systematic mutation set Telomere length decreased 2 YHR124W NDT80 competitive growth Competitive fitness decreased minimal medium 2 YHR124W NDT80 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YHR124W NDT80 large-scale survey Metal resistance decreased copper(2+) sulfate (2.5 mM) strong phenotype 2 YHR124W NDT80 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YHR129C ARP1 competitive growth Competitive fitness decreased minimal medium 2 YHR129C ARP1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YHR129C ARP1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YHR129C ARP1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YHR129C ARP1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YHR129C ARP1 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YHR129C ARP1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YHR129C ARP1 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) moderate sensitivity 2 YHR154W RTT107 classical genetics Resistance to chemicals decreased camptothecin (5 ug/ml) 2 YHR154W RTT107 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YHR154W RTT107 classical genetics Resistance to chemicals decreased methyl methanesulfonate (0.0025 percent) 2 YHR154W RTT107 competitive growth Competitive fitness decreased minimal medium 2 YHR154W RTT107 homozygous diploid Resistance to chemicals decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM) 2 YHR154W RTT107 homozygous diploid Resistance to chemicals decreased methyl methanesulfonate (0.0075%) 2 YHR154W RTT107 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YHR154W RTT107 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "high sensitivity, both relative fitness ratios below 0.88" 2 YHR154W RTT107 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YHR154W RTT107 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YHR154W RTT107 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YHR154W RTT107 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) moderate sensitivity 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) weak sensitivity 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YHR154W RTT107 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) sensitive relative to wildtype 2 YHR178W STB5 classical genetics Oxidative stress resistance decreased dicarboxylic acid diamide 2 YHR178W STB5 classical genetics Oxidative stress resistance decreased hydrogen peroxide (5 mM) 2 YHR178W STB5 classical genetics Resistance to chemicals decreased diamide 2 YHR178W STB5 competitive growth Competitive fitness decreased minimal medium 2 YHR178W STB5 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YHR178W STB5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YHR178W STB5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YHR178W STB5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YHR178W STB5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YHR178W STB5 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YHR178W STB5 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YHR178W STB5 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YHR178W STB5 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YHR178W STB5 systematic mutation set Resistance to chemicals decreased acetaldehyde (35 mM) 2 YHR178W STB5 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YHR178W STB5 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) strong sensitivity 2 YIL035C CKA1 competitive growth Competitive fitness decreased minimal medium 2 YIL035C CKA1 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YIL035C CKA1 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine (9 uM)" 2 YIL073C SPO22 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YIL073C SPO22 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YIL073C SPO22 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YIL073C SPO22 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YIL073C SPO22 systematic mutation set Transposable element transposition decreased Ty3 2 YIL103W DPH1 competitive growth Competitive fitness decreased minimal medium 2 YIL103W DPH1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YIL103W DPH1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YIL103W DPH1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YIL103W DPH1 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YIL116W HIS5 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YIL116W HIS5 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YIL153W RRD1 competitive growth Competitive fitness decreased minimal medium 2 YIL153W RRD1 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YIL153W RRD1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YIL153W RRD1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YIL153W RRD1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YIL153W RRD1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YIL153W RRD1 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YIL157C COA1 classical genetics Respiratory metabolism decreased 2 YIL157C COA1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YIL157C COA1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YIL157C COA1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YIL157C COA1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YIL157C COA1 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YIL157C COA1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YIL157C COA1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YIL157C COA1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YKL037W AIM26 competitive growth Competitive fitness decreased minimal medium 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Cell size decreased saturated glucose culture 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YKL037W AIM26 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) moderate growth defect 2 YKL037W AIM26 systematic mutation set Competitive fitness decreased galactose 2 YKL037W AIM26 systematic mutation set Competitive fitness decreased galactose 2 YKL037W AIM26 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YKL037W AIM26 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YKL037W AIM26 systematic mutation set Mitophagy decreased growth on lactate carbon source to post-log phase slight decrease 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YKL037W AIM26 systematic mutation set Toxin resistance decreased A. fumigatus gliotoxin 2 YKL113C RAD27 classical genetics Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YKL113C RAD27 competitive growth Competitive fitness decreased minimal medium 2 YKL113C RAD27 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YKL113C RAD27 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YKL113C RAD27 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YKL113C RAD27 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YKL113C RAD27 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YKL113C RAD27 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 2 YKL113C RAD27 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere 2 YKL113C RAD27 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) decreased growth in 0.5 mM paraquat 2 YKL113C RAD27 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YKL113C RAD27 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YKL113C RAD27 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YKL113C RAD27 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YKL214C YRA2 competitive growth Competitive fitness decreased minimal medium 2 YKR007W MEH1 classical genetics Nutrient uptake decreased citrulline 2 YKR007W MEH1 classical genetics Survival rate in stationary phase decreased "1000-fold reduction in colony-forming potential after 25 days in water, without losing viability" 2 YKR007W MEH1 competitive growth Competitive fitness decreased minimal medium 2 YKR007W MEH1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YKR007W MEH1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YKR007W MEH1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YKR007W MEH1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YKR007W MEH1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YKR007W MEH1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YKR007W MEH1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YKR007W MEH1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YKR007W MEH1 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YKR007W MEH1 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - trp medium) 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) strong sensitivity 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased rapamycin 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) strong sensitivity 2 YKR007W MEH1 systematic mutation set Resistance to chemicals decreased wortmannin 2 YKR010C TOF2 competitive growth Competitive fitness decreased minimal medium 2 YKR010C TOF2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YKR010C TOF2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YKR010C TOF2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YKR057W RPS21A competitive growth Competitive fitness decreased minimal medium 2 YKR057W RPS21A "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YKR057W RPS21A systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YKR085C MRPL20 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 2 YKR085C MRPL20 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YKR085C MRPL20 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YKR085C MRPL20 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YKR085C MRPL20 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YFR040W SAP155 classical genetics Resistance to chemicals decreased fluconazole (40 ug/ml) 2 YFR040W SAP155 classical genetics Resistance to chemicals decreased ketoconazole (30 ug/ml) 2 YFR040W SAP155 competitive growth Competitive fitness decreased minimal medium 2 YFR040W SAP155 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YFR040W SAP155 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 2 YFR040W SAP155 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YFR040W SAP155 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YFR040W SAP155 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YFR040W SAP155 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YFR040W SAP155 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YFR040W SAP155 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 2 YFR040W SAP155 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YFR040W SAP155 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YFR040W SAP155 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) moderate sensitivity 2 YDL020C RPN4 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YDL020C RPN4 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YDL020C RPN4 classical genetics Protein/peptide accumulation decreased Ptr2p-GFP 2 YDL020C RPN4 classical genetics Resistance to chemicals decreased 4-nitroquinoline N-oxide minimal inhibitory concentration deceased from 1.1 to 0.4 ug/ml 2 YDL020C RPN4 classical genetics Resistance to chemicals decreased cycloheximide minimal inhibitory concentration deceased from 0.11 to 0.06 ug/ml 2 YDL020C RPN4 classical genetics Resistance to chemicals decreased oligomycin minimal inhibitory concentration deceased from 1.1 to 0.6 ug/ml 2 YDL020C RPN4 classical genetics RNA accumulation decreased highly downregulated PTR2 mRNA 2 YDL020C RPN4 classical genetics Small molecule transport decreased Leu-Leu dipeptide 2 YDL020C RPN4 competitive growth Competitive fitness decreased minimal medium 2 YDL020C RPN4 homozygous diploid Resistance to chemicals decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM) 2 YDL020C RPN4 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDL020C RPN4 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YDL020C RPN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased benomyl (15 ug/ml) moderate growth defect 2 YDL020C RPN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YDL020C RPN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YDL020C RPN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YDL020C RPN4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YDL020C RPN4 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YDL020C RPN4 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YDL020C RPN4 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YDL020C RPN4 systematic mutation set Nutrient utilization decreased His-Leu dipeptide "cultured in minimal medium containing histidine, lysine, uracil and tryptophan" decreased ability to utilize the His-Leu dipeptide resulting in poor growth relative to the wildtype control 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased acetaldehyde (35 mM) 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased FK506 (2 ug/ml) weak sensitivity 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) moderate sensitivity 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased formaldehyde (1.5 mM) 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YDL020C RPN4 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YDL020C RPN4 systematic mutation set Telomere length decreased 2 YDL020C RPN4 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 2 YDL056W MBP1 competitive growth Competitive fitness decreased minimal medium 2 YDL056W MBP1 "heterozygous diploid, competitive growth" Resistance to chemicals decreased St. John's Wort extract 2 YDL056W MBP1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YDL056W MBP1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDL056W MBP1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YDL056W MBP1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YDL056W MBP1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YDL056W MBP1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) strong growth defect 2 YDL056W MBP1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YDL070W BDF2 competitive growth Competitive fitness decreased minimal medium 2 YDL070W BDF2 "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased tenovin-6 (20 micromolar) 2 YDL083C RPS16B competitive growth Competitive fitness decreased minimal medium 2 YDL083C RPS16B large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YDL083C RPS16B large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YDL083C RPS16B systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YDL106C PHO2 classical genetics Chemical compound excretion decreased N-ribosylnicotinamide 2 YDL106C PHO2 classical genetics Resistance to chemicals decreased disodium selenite (5 mM) 2 YDL106C PHO2 classical genetics Resistance to chemicals decreased quinine 2 YDL106C PHO2 homozygous diploid Chronological lifespan decreased 2 YDL106C PHO2 homozygous diploid Oxidative stress resistance decreased hydrogen peroxide (2 mM) 2 YDL106C PHO2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) moderate growth defect 2 YDL106C PHO2 "homozygous diploid, systematic mutation set" Utilization of phosphorus source decreased low phosphate YPD medium strong growth defect 2 YDL106C PHO2 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YDL106C PHO2 systematic mutation set Resistance to chemicals decreased Echinacea extract 2 YDL106C PHO2 systematic mutation set Resistance to chemicals decreased PM02734 (250 ug/ml; synthetic cyclic depsipeptide related to natural kahalalides) 2 YDL106C PHO2 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YDL106C PHO2 systematic mutation set Toxin resistance decreased Ala-Eth dipeptide (0.1 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YDL133W SRF1 classical genetics Chemical compound accumulation decreased calcium(2+) cells treated with alpha factor decreased low-affinity Ca2+ influx 2 YDL133W SRF1 classical genetics Resistance to chemicals decreased 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (40 uM) 2 YDL133W SRF1 competitive growth Competitive fitness decreased minimal medium 2 YDL133W SRF1 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YDL133W SRF1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YDL133W SRF1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YDL133W SRF1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YDL144C competitive growth Competitive fitness decreased minimal medium 2 YDL231C BRE4 competitive growth Competitive fitness decreased minimal medium 2 YDL231C BRE4 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YDL231C BRE4 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YDR136C VPS61 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form in the presence of monensin carboxypeptidase Y (Prc1p) 2 YDR136C VPS61 classical genetics Resistance to chemicals decreased FK506 2 YDR136C VPS61 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR136C VPS61 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 2 YDR136C VPS61 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.2 M LiCl) 2 YDR136C VPS61 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YDR136C VPS61 systematic mutation set Metal resistance decreased aluminium(3+) (0.4 mM) 2 YDR136C VPS61 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased FK506 (2 ug/ml) weak sensitivity 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased monensin (50 uM) moderately sensitive 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased rapamycin 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YDR149C competitive growth Competitive fitness decreased minimal medium 2 YDR149C "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YDR149C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YDR149C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YDR159W SAC3 classical genetics Metal resistance decreased nickel(2+) 2 YDR159W SAC3 classical genetics Protein/peptide accumulation decreased reduced temperature (20 deg C) polysome profile indicates a defect in biogenesis of the small ribosomal subunit 40S ribosomal subunit 2 YDR159W SAC3 classical genetics RNA localization decreased permissive temperature (30 deg C) nuclear export defective poly (A)+ mRNA 2 YDR159W SAC3 competitive growth Competitive fitness decreased minimal medium 2 YDR159W SAC3 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YDR159W SAC3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR159W SAC3 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YDR159W SAC3 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YDR159W SAC3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YDR159W SAC3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YDR159W SAC3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) weak sensitivity 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) weak sensitivity 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased rapamycin 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) strong sensitivity 2 YDR174W HMO1 competitive growth Competitive fitness decreased minimal medium 2 YDR174W HMO1 homozygous diploid Oxidative stress resistance decreased hydrogen peroxide (2 mM) 2 YDR174W HMO1 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YDR174W HMO1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR174W HMO1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YDR174W HMO1 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YDR174W HMO1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YDR174W HMO1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YDR174W HMO1 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YDR174W HMO1 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 2 YDR207C UME6 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YDR207C UME6 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YDR207C UME6 classical genetics Resistance to chemicals decreased 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (40 uM) 2 YDR207C UME6 competitive growth Competitive fitness decreased minimal medium 2 YDR207C UME6 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YDR207C UME6 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YDR207C UME6 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR207C UME6 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) moderate growth defect 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YDR207C UME6 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) moderate growth defect 2 YDR207C UME6 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YDR207C UME6 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YDR207C UME6 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YDR207C UME6 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YDR207C UME6 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased Calcofluor White 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) weak sensitivity 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased rapamycin 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) strong sensitivity 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased wortmannin 2 YDR264C AKR1 classical genetics Metal resistance decreased zinc dichloride (4 mM) 2 YDR264C AKR1 classical genetics Protein/peptide modification decreased reduced processing of Prc1p to mature form carboxypeptidase Y (Prc1p) 2 YDR264C AKR1 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YDR264C AKR1 "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased sodium arsenite (450 uM) 2 YDR264C AKR1 homozygous diploid Resistance to chemicals decreased Calcofluor White (8.2 micromolar) 2 YDR264C AKR1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 66% zymocin 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) strong growth defect 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Utilization of phosphorus source decreased low phosphate YPD medium moderate growth defect 2 YDR264C AKR1 large-scale survey Metal resistance decreased copper(2+) sulfate (2.5 mM) strong phenotype 2 YDR264C AKR1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) moderate sensitivity 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) moderate sensitivity 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) strong sensitivity 2 YDR264C AKR1 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YDR268W MSW1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR268W MSW1 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YDR268W MSW1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YDR268W MSW1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YDR268W MSW1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) strong growth defect 2 YDR268W MSW1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YDR272W GLO2 competitive growth Competitive fitness decreased minimal medium 2 YDR272W GLO2 systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 2 YDR272W GLO2 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YDR293C SSD1 classical genetics Resistance to chemicals decreased Calcofluor White 2 YDR293C SSD1 classical genetics Resistance to chemicals decreased Calcofluor White (50 ug/ml) heat shock at 46 deg C for 30 min 2 YDR293C SSD1 classical genetics Resistance to chemicals decreased sodium dodecyl sulfate (0.03%) 2 YDR293C SSD1 classical genetics Resistance to enzymatic treatment decreased heat shock at 46 deg C for 30 min increased zymolyase sensitivity 2 YDR293C SSD1 classical genetics Thermotolerance decreased "pretreatment at 37 deg C for 30 min, then heat shock at 50 deg C for 30 min" 2 YDR293C SSD1 classical genetics Toxin resistance decreased "PAF26, de novo-designed antimicrobial hexapeptide (64 uM)" 2 YDR293C SSD1 competitive growth Competitive fitness decreased minimal medium 2 YDR293C SSD1 "heterozygous diploid, competitive growth" Resistance to chemicals decreased St. John's Wort extract 2 YDR293C SSD1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR293C SSD1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YDR293C SSD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YDR293C SSD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YDR293C SSD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YDR293C SSD1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YDR293C SSD1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YDR293C SSD1 large-scale survey Resistance to chemicals decreased pyocyanin (75 μg/ml) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased miconazole at least 4-fold reduced MIC compared to 1 ug/ml wt MIC 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased rapamycin 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YDR293C SSD1 systematic mutation set Toxin resistance decreased Ala-Eth dipeptide (0.1 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YDR320C SWA2 competitive growth Competitive fitness decreased minimal medium 2 YDR320C SWA2 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YDR320C SWA2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR320C SWA2 "homozygous diploid, large-scale survey" Cell size decreased small cell size; weak defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) moderate growth defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 500 mM KCl 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) moderate growth defect 2 YDR320C SWA2 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YDR320C SWA2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YDR320C SWA2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YDR320C SWA2 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YDR320C SWA2 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YDR320C SWA2 systematic mutation set Resistance to chemicals decreased rapamycin 2 YDR320C SWA2 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YDR320C SWA2 systematic mutation set Telomere length decreased 2 YDR378C LSM6 classical genetics Nuclear export decreased reduced temperature (20 deg C) large ribosomal subunits accumulate in the nucleus 60S ribosomal subunit 2 YDR378C LSM6 classical genetics Resistance to chemicals decreased 5-fluorouracil (1 ug/mL) elevated temperature (38 deg C) 2 YDR378C LSM6 competitive growth Competitive fitness decreased minimal medium 2 YDR378C LSM6 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR378C LSM6 "homozygous diploid, competitive growth" UV resistance decreased "high sensitivity, three or more relative fitness ratios below 0.92" 2 YDR378C LSM6 "homozygous diploid, large-scale survey" Budding index decreased 2 YDR378C LSM6 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YDR378C LSM6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YDR378C LSM6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YDR378C LSM6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YDR378C LSM6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased Calcofluor White 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) moderate sensitivity 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased rapamycin 2 YDR378C LSM6 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) strong sensitivity 2 YDR422C SIP1 classical genetics Dessication resistance decreased mutants grown to post-diauxic phase and then subject to desiccation moderately affected with 35-60% survival after desiccation 2 YDR422C SIP1 classical genetics Replicative lifespan decreased mean lifespan was reduced to 82% that of the wild type 2 YDR422C SIP1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YDR432W NPL3 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YDR432W NPL3 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YDR432W NPL3 classical genetics Resistance to chemicals decreased 6-azauridine 2 YDR432W NPL3 classical genetics Resistance to chemicals decreased FK506 2 YDR432W NPL3 classical genetics Resistance to chemicals decreased mycophenolic acid 2 YDR432W NPL3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR432W NPL3 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YDR432W NPL3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YDR432W NPL3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YDR432W NPL3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YDR432W NPL3 "homozygous diploid, systematic mutation set" Utilization of phosphorus source decreased low phosphate YPD medium moderate growth defect 2 YDR432W NPL3 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YDR432W NPL3 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 2 YDR432W NPL3 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YDR432W NPL3 systematic mutation set Nutrient utilization decreased His-Leu dipeptide "cultured in minimal medium containing histidine, lysine, uracil and tryptophan" decreased ability to utilize the His-Leu dipeptide resulting in poor growth relative to the wildtype control 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased caspofungin 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YDR432W NPL3 systematic mutation set Transposable element transposition decreased moderate decrease in Ty1 mobility 2 YDR441C APT2 competitive growth Competitive fitness decreased minimal medium 2 YDR441C APT2 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YDR452W PPN1 competitive growth Competitive fitness decreased minimal medium 2 YDR456W NHX1 classical genetics Acid pH resistance decreased pH 2.7 medium 2 YDR456W NHX1 classical genetics Chemical compound accumulation decreased chloride 2 YDR456W NHX1 classical genetics Ionic stress resistance decreased potassium chloride (0.8 M) 2 YDR456W NHX1 classical genetics Resistance to chemicals decreased gentamycin (500 ug/ml) growth inhibited by 80% 2 YDR456W NHX1 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YDR456W NHX1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YDR456W NHX1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YDR456W NHX1 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YDR456W NHX1 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YDR456W NHX1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YDR520C URC2 competitive growth Competitive fitness decreased minimal medium 2 YDR525W API2 classical genetics Chemical compound accumulation decreased calcium(2+) cells treated with alpha factor decreased low-affinity Ca2+ influx 2 YDR525W API2 classical genetics Resistance to chemicals decreased Calcofluor White (150 ug/ml) 25 deg C 2 YDR525W API2 classical genetics Resistance to chemicals decreased staurosporine 2 YDR525W API2 competitive growth Competitive fitness decreased minimal medium 2 YDR525W API2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YDR525W API2 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YDR525W API2 systematic mutation set Resistance to chemicals decreased PM02734 (250 ug/ml; synthetic cyclic depsipeptide related to natural kahalalides) 2 YDR525W API2 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YGL025C PGD1 classical genetics Telomere length decreased 2 YGL025C PGD1 classical genetics Utilization of carbon source decreased oleic acid 2 YGL025C PGD1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YGL025C PGD1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL025C PGD1 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YGL025C PGD1 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) moderate growth defect 2 YGL025C PGD1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YGL025C PGD1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YGL025C PGD1 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) fails to grow in 100% oxygen atmosphere 2 YGL025C PGD1 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) decreased growth in 0.5 mM paraquat 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased wortmannin 2 YGL025C PGD1 systematic mutation set Telomere length decreased 2 YGL025C PGD1 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 2 YGL066W SGF73 classical genetics Chronological lifespan decreased survival during aging strongly reduced; spermiidine increases survival during early aging (day 15-25) 2 YGL066W SGF73 competitive growth Competitive fitness decreased minimal medium 2 YGL066W SGF73 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL066W SGF73 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YGL066W SGF73 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YGL066W SGF73 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YGL066W SGF73 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YGL066W SGF73 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YGL066W SGF73 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YGL066W SGF73 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YGL066W SGF73 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml or 4 ug/ml CTBT 2 YGL066W SGF73 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGL066W SGF73 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YGL066W SGF73 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) weak sensitivity 2 YGL066W SGF73 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 2 YGL071W AFT1 classical genetics Alkaline pH resistance decreased pH 6.8 2 YGL071W AFT1 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YGL071W AFT1 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YGL071W AFT1 classical genetics Metal resistance decreased zinc dichloride (2 mM) 2 YGL071W AFT1 classical genetics Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) sensitivity is rescued by addition of 2 mM FeCl2 or 1 mM CuSO4 2 YGL071W AFT1 classical genetics Resistance to chemicals decreased zinc(2+) (4 mM ZnSO4) 2 YGL071W AFT1 homozygous diploid Resistance to chemicals decreased bathophenanthroline bisulfonate (BPS) (80 uM) 2 YGL071W AFT1 homozygous diploid Resistance to chemicals decreased BPS (100 uM bathophenanthrolinebisulfonic acid) 2 YGL071W AFT1 homozygous diploid Resistance to chemicals decreased curcumin (150 uM) curcumin sensitivity is rescued by addition of 50 uM Fe2SO4 2 YGL071W AFT1 homozygous diploid Resistance to chemicals decreased ethylenediaminetetraacetic acid (0.25 mM) 2 YGL071W AFT1 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Utilization of iron source decreased bathophenanthroline (200 uM) YPD medium strong growth defect 2 YGL071W AFT1 "homozygous diploid, systematic mutation set" Vegetative growth decreased low iron level in media 2 YGL071W AFT1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YGL071W AFT1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YGL086W MAD1 classical genetics Resistance to chemicals decreased benomyl (12.5 ug/ml) 2 YGL086W MAD1 classical genetics Spore germination decreased 2 YGL086W MAD1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YGL086W MAD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased benomyl (15 ug/ml) moderate growth defect 2 YGL086W MAD1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YGL086W MAD1 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) weak sensitivity 2 YGL086W MAD1 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YGL135W RPL1B "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YGL135W RPL1B "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL135W RPL1B "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YGL135W RPL1B "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YGL135W RPL1B systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YGL135W RPL1B systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YGL135W RPL1B systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YGL135W RPL1B systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGL135W RPL1B systematic mutation set Resistance to chemicals decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type 2 YGL135W RPL1B systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YGL135W RPL1B systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YGL135W RPL1B systematic mutation set Telomere length decreased 2 YGL135W RPL1B systematic mutation set Transposable element transposition decreased moderate decrease in Ty1 mobility 2 YGL143C MRF1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL143C MRF1 "homozygous diploid, large-scale survey" Resistance to chemicals decreased cisplatin (250 ug/ml) 2 YGL143C MRF1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YGL143C MRF1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YGL143C MRF1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YGL143C MRF1 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YGL143C MRF1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YGL143C MRF1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGL143C MRF1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YGL148W ARO2 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 2 YGL148W ARO2 competitive growth Competitive fitness decreased minimal medium 2 YGL148W ARO2 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YGL148W ARO2 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YGL148W ARO2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL148W ARO2 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YGL148W ARO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YGL148W ARO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YGL148W ARO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YGL148W ARO2 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YGL148W ARO2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YGL148W ARO2 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YGL148W ARO2 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YGL148W ARO2 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YGL148W ARO2 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YGL148W ARO2 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YGL148W ARO2 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - trp medium) 2 YGL148W ARO2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) weak sensitivity 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased miconazole at least 4-fold reduced MIC compared to 1 ug/ml wt MIC 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YGL167C PMR1 classical genetics Alkaline pH resistance decreased pH 7.1 - pH 7.3 2 YGL167C PMR1 classical genetics Autophagy decreased autophagy assayed by delivery of cytoplasmic Pho8p to vacuole;slight decrease; autophagy is normal in SEY6210 strain background 2 YGL167C PMR1 classical genetics Metal resistance decreased zinc(2+) 2 YGL167C PMR1 classical genetics Protein/peptide modification decreased reduced processing of Prc1p to mature form carboxypeptidase Y (Prc1p) 2 YGL167C PMR1 classical genetics Resistance to chemicals decreased calcofluor white (20 micrograms/ml) 2 YGL167C PMR1 competitive growth Competitive fitness decreased minimal medium 2 YGL167C PMR1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YGL167C PMR1 homozygous diploid Oxidative stress resistance decreased hydrogen peroxide (2 mM) 2 YGL167C PMR1 homozygous diploid Resistance to chemicals decreased Calcofluor White (8.2 micromolar) 2 YGL167C PMR1 homozygous diploid Resistance to chemicals decreased "L-1,4-dithiothreitol" 2 YGL167C PMR1 homozygous diploid Resistance to chemicals decreased mercaptoethanol (30 mM) 2 YGL167C PMR1 homozygous diploid Resistance to chemicals decreased Plakortide F Acid (~0.02 ug/ml) 2 YGL167C PMR1 homozygous diploid Resistance to chemicals decreased tunicamycin (1 microgram/mL) 2 YGL167C PMR1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL167C PMR1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YGL167C PMR1 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YGL167C PMR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YGL167C PMR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YGL167C PMR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YGL167C PMR1 "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YGL167C PMR1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YGL167C PMR1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YGL167C PMR1 systematic mutation set Metal resistance decreased aluminium(3+) (0.6 mM) 2 YGL167C PMR1 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 2 YGL167C PMR1 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere 2 YGL167C PMR1 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) decreased growth in 0.5 mM paraquat 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) moderate sensitivity 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased wortmannin 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) moderate sensitivity 2 YGL195W GCN1 competitive growth Competitive fitness decreased minimal medium 2 YGL195W GCN1 "heterozygous diploid, competitive growth" Resistance to chemicals decreased St. John's Wort extract 2 YGL195W GCN1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YGL195W GCN1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGL195W GCN1 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) moderate sensitivity 2 YGL223C COG1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL223C COG1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YGL223C COG1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YGL223C COG1 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YGL229C SAP4 competitive growth Competitive fitness decreased minimal medium 2 YGL229C SAP4 "homozygous diploid, competitive growth" UV resistance decreased "moderate sensitivity, two relative fitness ratios below 0.92" 2 YGL229C SAP4 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YGL231C EMC4 competitive growth Competitive fitness decreased minimal medium 2 YGL231C EMC4 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YGL246C RAI1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) moderate growth defect 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Utilization of phosphorus source decreased low phosphate YPD medium moderate growth defect 2 YGL246C RAI1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YGL246C RAI1 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YGR163W GTR2 classical genetics Metal resistance decreased zinc(2+) (13 mM ZnSO4) minimal medium (SD agar) 2 YGR163W GTR2 classical genetics Nutrient uptake decreased citrulline 2 YGR163W GTR2 competitive growth Competitive fitness decreased minimal medium 2 YGR163W GTR2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGR163W GTR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YGR163W GTR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YGR163W GTR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YGR163W GTR2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YGR163W GTR2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) strong sensitivity 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased rapamycin 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) strong sensitivity 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased rapamycin (11 nM) 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased wortmannin 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) moderate sensitivity 2 YGR163W GTR2 systematic mutation set Telomere length decreased 2 YGR252W GCN5 classical genetics Chronological lifespan decreased survival during aging strongly reduced; spermiidine increases survival during early aging (day 15-25) 2 YGR252W GCN5 classical genetics Resistance to chemicals decreased 6-azauracil (100 ug/ml) 2 YGR252W GCN5 classical genetics Resistance to chemicals decreased Calcofluor White (7.5 ug/ml) 2 YGR252W GCN5 classical genetics Resistance to chemicals decreased cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone 2 YGR252W GCN5 classical genetics Resistance to chemicals decreased rapamycin (2 nM) 2 YGR252W GCN5 classical genetics Resistance to chemicals decreased staurosporine (2 ug/ml);Calcofluor White (7.5 ug/ml) 2 YGR252W GCN5 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YGR252W GCN5 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YGR252W GCN5 "homozygous diploid, large-scale survey" Resistance to chemicals decreased cisplatin (250 ug/ml) 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YGR252W GCN5 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YGR252W GCN5 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YGR252W GCN5 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YGR252W GCN5 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YGR252W GCN5 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased miconazole at least 4-fold reduced MIC compared to 1 ug/ml wt MIC 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YGR252W GCN5 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YJL053W PEP8 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 2 YJL053W PEP8 competitive growth Competitive fitness decreased minimal medium 2 YJL053W PEP8 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YJL053W PEP8 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YJL053W PEP8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YJL053W PEP8 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJL053W PEP8 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YJL053W PEP8 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YJL053W PEP8 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 2 YJL053W PEP8 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 2 YJL053W PEP8 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YJL053W PEP8 systematic mutation set Resistance to chemicals decreased dihydromotuporamine C 2 YJL053W PEP8 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YJL053W PEP8 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YJL053W PEP8 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YJL073W JEM1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YJL073W JEM1 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YJL141C YAK1 classical genetics Dessication resistance decreased mutants grown to post-diauxic phase and then subject to desiccation moderately affected with 35-60% survival after desiccation 2 YJL141C YAK1 competitive growth Competitive fitness decreased minimal medium 2 YJL141C YAK1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YJL141C YAK1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YJL141C YAK1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YJL141C YAK1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YJL154C VPS35 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 2 YJL154C VPS35 competitive growth Competitive fitness decreased minimal medium 2 YJL154C VPS35 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YJL154C VPS35 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YJL154C VPS35 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YJL154C VPS35 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YJL154C VPS35 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YJL154C VPS35 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJL154C VPS35 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YJL154C VPS35 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 2 YJL154C VPS35 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 2 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased rapamycin 2 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YJL154C VPS35 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YJL188C BUD19 competitive growth Competitive fitness decreased minimal medium 2 YJL188C BUD19 homozygous diploid Oxidative stress resistance decreased hydrogen peroxide (2 mM) 2 YJL188C BUD19 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YJL188C BUD19 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YJL188C BUD19 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YJL188C BUD19 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; slight growth inhibition in the presence of 25 ug/ml doxorubicin 2 YJL188C BUD19 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YJL188C BUD19 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YJL188C BUD19 systematic mutation set Metal resistance decreased aluminium(3+) (0.4 mM) 2 YJL188C BUD19 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) moderate sensitivity 2 YJR032W CPR7 classical genetics Resistance to chemicals decreased azetidine-2-carboxylic acid (0.5 mg/ml) azetidine-2-carboxylic acid (AZC) is a proline analog that prevents correct folding when incorporated into proteins 2 YJR032W CPR7 classical genetics Resistance to chemicals decreased cycloheximide (0.025 ug/ml) 2 YJR032W CPR7 classical genetics Resistance to chemicals decreased hygromycin (50 ug/ml) 2 YJR032W CPR7 competitive growth Competitive fitness decreased minimal medium 2 YJR032W CPR7 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YJR032W CPR7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YJR032W CPR7 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJR032W CPR7 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YJR032W CPR7 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YJR032W CPR7 systematic mutation set Resistance to chemicals decreased glucose (30% (w/v)) mutant attains a lower final biomass than wild type 2 YJR032W CPR7 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YJR032W CPR7 systematic mutation set Transposable element transposition decreased Ty3 2 YJR033C RAV1 classical genetics Metal resistance decreased nickel(2+) 2 YJR033C RAV1 classical genetics Resistance to chemicals decreased propolis extract (0.5%) 2 YJR033C RAV1 competitive growth Competitive fitness decreased minimal medium 2 YJR033C RAV1 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YJR033C RAV1 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 2 YJR033C RAV1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YJR033C RAV1 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;partial growth inhibition on exposure to 66% zymocin; not inhibited by 33% zymocin 2 YJR033C RAV1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YJR033C RAV1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJR033C RAV1 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) weak sensitivity 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased rapamycin 2 YJR102C VPS25 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form in the presence of monensin carboxypeptidase Y (Prc1p) 2 YJR102C VPS25 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YJR102C VPS25 classical genetics Toxin resistance decreased Ala-Eth dipeptide (0.1-0.2 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YJR102C VPS25 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.2 M LiCl) 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) moderate growth defect 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YJR102C VPS25 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YJR102C VPS25 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJR102C VPS25 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YJR102C VPS25 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YJR102C VPS25 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased caspofungin 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased dihydromotuporamine C 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) strong sensitivity 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) sensitive relative to wildtype 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YJR102C VPS25 systematic mutation set Telomere length decreased 2 YJR102C VPS25 systematic mutation set Transposable element transposition decreased Ty3 2 YJR108W ABM1 competitive growth Competitive fitness decreased minimal medium 2 YJR108W ABM1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YJR108W ABM1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJR108W ABM1 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YJR118C ILM1 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YJR118C ILM1 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YJR118C ILM1 classical genetics Resistance to chemicals decreased FK506 2 YJR118C ILM1 classical genetics Resistance to chemicals decreased oleate (0.1%) 2 YJR118C ILM1 competitive growth Competitive fitness decreased minimal medium 2 YJR118C ILM1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YJR118C ILM1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YJR118C ILM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YJR118C ILM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 500 mM KCl 2 YJR118C ILM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YJR118C ILM1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YJR118C ILM1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJR118C ILM1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YJR118C ILM1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YJR118C ILM1 systematic mutation set Nutrient utilization decreased His-Leu dipeptide "cultured in minimal medium containing histidine, lysine, uracil and tryptophan" decreased ability to utilize the His-Leu dipeptide resulting in poor growth relative to the wildtype control 2 YJR118C ILM1 systematic mutation set Resistance to chemicals decreased Calcofluor White 2 YJR118C ILM1 systematic mutation set Resistance to chemicals decreased caspofungin 2 YJR118C ILM1 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YJR118C ILM1 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YJR118C ILM1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YJR118C ILM1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YJR139C HOM6 classical genetics Gamma ray resistance decreased slightly sensitive (10-50% survival) 2 YJR139C HOM6 classical genetics Resistance to chemicals decreased camptothecin (10 uM) 10 fold reduction in viability 2 YJR139C HOM6 classical genetics Resistance to chemicals decreased cisplatin (80 uM) less than 10 fold reduction in viability 2 YJR139C HOM6 classical genetics Resistance to chemicals decreased daunorubicin (10 uM) 100 fold reduction in viability 2 YJR139C HOM6 classical genetics Resistance to chemicals decreased FK506 2 YJR139C HOM6 competitive growth Competitive fitness decreased minimal medium 2 YJR139C HOM6 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YJR139C HOM6 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YJR139C HOM6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YJR139C HOM6 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YJR139C HOM6 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YJR139C HOM6 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - lys medium) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete medium) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - thr medium) 2 YJR139C HOM6 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete - trp medium) 2 YJR139C HOM6 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YJR139C HOM6 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased acetaldehyde (35 mM) 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) hypersensitive (100-1000 fold decrease in survival relative to wildtype) 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased rapamycin 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased wortmannin 2 YLL002W RTT109 competitive growth Competitive fitness decreased minimal medium 2 YLL002W RTT109 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YLL002W RTT109 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLL002W RTT109 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YLL002W RTT109 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YLL002W RTT109 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YLL002W RTT109 systematic mutation set Protein/peptide accumulation decreased Hta1p-GFP 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) strong sensitivity 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) strong sensitivity 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YLL002W RTT109 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YLR025W SNF7 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form; processing is further reduced in the presence of monensin carboxypeptidase Y (Prc1p) 2 YLR025W SNF7 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YLR025W SNF7 homozygous diploid Sporulation efficiency decreased percent of cells forming 4-spored asci (less than 1%) 2 YLR025W SNF7 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YLR025W SNF7 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YLR025W SNF7 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "weak sensitivity, one relative fitness ratio below 0.92" 2 YLR025W SNF7 "homozygous diploid, large-scale survey" Sporulation decreased 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) strong growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) moderate growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YLR025W SNF7 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YLR025W SNF7 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YLR025W SNF7 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YLR025W SNF7 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YLR025W SNF7 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YLR025W SNF7 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YLR025W SNF7 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) weak sensitivity 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YLR025W SNF7 systematic mutation set Telomere length decreased 2 YLR025W SNF7 systematic mutation set Toxin resistance decreased Ala-Eth dipeptide (0.1 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YLR025W SNF7 systematic mutation set Transposable element transposition decreased Ty3 2 YLR027C AAT2 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 2 YLR027C AAT2 classical genetics Resistance to chemicals decreased hydroxyurea (50 - 200 mM) 2 YLR027C AAT2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR027C AAT2 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine (9 uM)" 2 YLR027C AAT2 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YLR027C AAT2 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YLR027C AAT2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YLR027C AAT2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YLR027C AAT2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YLR027C AAT2 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YLR027C AAT2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YLR027C AAT2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YLR027C AAT2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YLR027C AAT2 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YLR039C RIC1 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form in the presence of monensin carboxypeptidase Y (Prc1p) 2 YLR039C RIC1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR039C RIC1 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 2 YLR039C RIC1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YLR039C RIC1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YLR039C RIC1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YLR039C RIC1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YLR039C RIC1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YLR039C RIC1 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YLR039C RIC1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YLR039C RIC1 systematic mutation set Metal resistance decreased aluminium(3+) (0.4 mM) 2 YLR039C RIC1 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YLR039C RIC1 systematic mutation set Oxidative stress resistance decreased tert-butyl hydroperoxide (t-BuOOH) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased 4-nitroquinoline N-oxide 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased monensin (50 uM) hypersensitive 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) inviable after 3 day exposure 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased PM02734 (250 ug/ml; synthetic cyclic depsipeptide related to natural kahalalides) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YLR039C RIC1 systematic mutation set UV resistance decreased UV irradiation (254 nm) 2 YLR068W FYV7 classical genetics Metal resistance decreased cadmium(2+) (50 uM) 2 YLR068W FYV7 classical genetics Metal resistance decreased nickel(2+) (2.5 mM) 2 YLR068W FYV7 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR068W FYV7 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YLR068W FYV7 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YLR068W FYV7 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YLR068W FYV7 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YLR068W FYV7 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YLR068W FYV7 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YLR181C VTA1 competitive growth Competitive fitness decreased minimal medium 2 YLR181C VTA1 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YLR181C VTA1 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YLR226W BUR2 classical genetics Metal resistance decreased zinc dichloride (4 mM) 2 YLR226W BUR2 classical genetics Protein/peptide modification decreased phosphorylation of Ser2 reduced Rpo21p 2 YLR226W BUR2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR226W BUR2 "homozygous diploid, large-scale survey" Budding index decreased 2 YLR226W BUR2 "homozygous diploid, large-scale survey" Resistance to chemicals decreased cisplatin (250 ug/ml) 2 YLR226W BUR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YLR226W BUR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YLR226W BUR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YLR226W BUR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YLR226W BUR2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YLR226W BUR2 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YLR226W BUR2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YLR226W BUR2 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased hygromycin B (slow growth at 25 ug/mL and 50 ug/mL) 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YLR226W BUR2 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YLR322W VPS65 classical genetics Metal resistance decreased zinc dichloride (4 mM) 2 YLR322W VPS65 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR322W VPS65 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YLR322W VPS65 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YLR322W VPS65 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YLR322W VPS65 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YLR322W VPS65 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YLR322W VPS65 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YLR322W VPS65 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YLR322W VPS65 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YLR322W VPS65 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YLR322W VPS65 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YLR322W VPS65 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YLR322W VPS65 systematic mutation set Metal resistance decreased manganese(2+) (10mM) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) weak sensitivity 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased caspofungin 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased rapamycin 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased wortmannin 2 YLR370C ARC18 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form; processing is further reduced in the presence of monensin carboxypeptidase Y (Prc1p) 2 YLR370C ARC18 competitive growth Competitive fitness decreased minimal medium 2 YLR370C ARC18 homozygous diploid Resistance to chemicals decreased benomyl (10 ug/ml) 2 YLR370C ARC18 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR370C ARC18 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YLR370C ARC18 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YLR370C ARC18 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YLR370C ARC18 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YLR370C ARC18 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YLR370C ARC18 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YLR370C ARC18 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YLR370C ARC18 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YLR396C VPS33 classical genetics Protein/peptide modification decreased reduced processing of Prc1p to mature form carboxypeptidase Y (Prc1p) 2 YLR396C VPS33 classical genetics Resistance to chemicals decreased caffeine (6 mM) 2 YLR396C VPS33 classical genetics Resistance to chemicals decreased hygromycin B (50 micrograms/ml) 2 YLR396C VPS33 classical genetics Resistance to chemicals decreased staurosporine (5 micrograms/ml) 2 YLR396C VPS33 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YLR396C VPS33 classical genetics Resistance to chemicals decreased trisodium vanadate (4 mM) 2 YLR396C VPS33 classical genetics Toxin resistance decreased alpha-synuclein 2 YLR396C VPS33 homozygous diploid Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) hypersensitive 2 YLR396C VPS33 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR396C VPS33 "homozygous diploid, large-scale survey" Resistance to chemicals decreased cisplatin (250 ug/ml) 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.1 M LiCl) 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Metal resistance decreased zinc sulfate (1000 uM) effective concentration (EC) 10 with growth inhibition greater than or equal to 80% 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YLR396C VPS33 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 2 YLR396C VPS33 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YLR396C VPS33 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YLR396C VPS33 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YLR396C VPS33 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere 2 YLR396C VPS33 systematic mutation set Oxidative stress resistance decreased hydrogen peroxide (2 mM) fails to grow in 2 mM H2O2 2 YLR396C VPS33 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) fails to grow in 0.5 mM paraquat 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased monensin (50 uM) hypersensitive 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YLR417W VPS36 classical genetics Autophagy decreased severe decrease in autophagy; cvt pathway is also severely decreased;autophagy assayed by delivery of cytoplasmic Pho8p to vacuole 2 YLR417W VPS36 classical genetics Mitophagy decreased growth on lactate carbon source to post-log phase severe decrease 2 YLR417W VPS36 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YLR417W VPS36 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YLR417W VPS36 "homozygous diploid, competitive growth" Resistance to chemicals decreased curcumin (150 uM) competitive growth for 5 generations in 150 uM curcumin 2 YLR417W VPS36 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "weak sensitivity, one relative fitness ratio below 0.92" 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.2 M LiCl) 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) moderate growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) moderate growth defect 2 YLR417W VPS36 large-scale survey Resistance to chemicals decreased pyocyanin (75 μg/ml) 2 YLR417W VPS36 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YLR417W VPS36 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YLR417W VPS36 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YLR417W VPS36 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YLR417W VPS36 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased dihydromotuporamine C 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) sensitive (10-100 fold decreased survival relative to wildtype) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) strong sensitivity 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased rapamycin 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) moderate sensitivity 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YLR417W VPS36 systematic mutation set Telomere length decreased 2 YLR417W VPS36 systematic mutation set Toxin resistance decreased Ala-Eth dipeptide (0.1 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YLR417W VPS36 systematic mutation set Transposable element transposition decreased Ty3 2 YLR435W TSR2 competitive growth Competitive fitness decreased minimal medium 2 YLR435W TSR2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.1 M LiCl) 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) moderate growth defect 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 66% zymocin 2 YLR435W TSR2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YLR435W TSR2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YLR435W TSR2 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YLR435W TSR2 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YLR435W TSR2 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YML116W-A systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YML121W GTR1 classical genetics Metal resistance decreased zinc(2+) (13 mM ZnSO4) minimal medium (SD agar) 2 YML121W GTR1 classical genetics Nutrient uptake decreased citrulline 2 YML121W GTR1 classical genetics Resistance to chemicals decreased rapamycin (5 ng/ml) 2 YML121W GTR1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YML121W GTR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YML121W GTR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YML121W GTR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YML121W GTR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YML121W GTR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YML121W GTR1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YML121W GTR1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) strong sensitivity 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased rapamycin 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) strong sensitivity 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased wortmannin 2 YML121W GTR1 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) moderate sensitivity 2 YML121W GTR1 systematic mutation set Telomere length decreased 2 YMR077C VPS20 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YMR077C VPS20 classical genetics Survival rate in stationary phase decreased "10,000-fold reduction in colony-forming potential after 25 days in water, without losing viability" 2 YMR077C VPS20 classical genetics Toxin resistance decreased Ala-Eth dipeptide (0.1-0.2 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YMR077C VPS20 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YMR077C VPS20 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR077C VPS20 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.4 M LiCl) 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) moderate growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YMR077C VPS20 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) moderate growth defect 2 YMR077C VPS20 large-scale survey Resistance to chemicals decreased pyocyanin (75 μg/ml) 2 YMR077C VPS20 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YMR077C VPS20 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YMR077C VPS20 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased "CTBT (4 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" no growth on YPD plus 4 ug/ml CTBT 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased oxalic acid (30 millimolar) 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased rapamycin 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YMR077C VPS20 systematic mutation set Transposable element transposition decreased Ty3 2 YMR091C NPL6 classical genetics Mating efficiency decreased 2 YMR091C NPL6 "heterozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR091C NPL6 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YMR091C NPL6 "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased sodium arsenite (450 uM) 2 YMR091C NPL6 homozygous diploid Gamma ray resistance decreased 2 YMR091C NPL6 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR091C NPL6 "homozygous diploid, competitive growth" Gamma ray resistance decreased 2 YMR091C NPL6 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YMR091C NPL6 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YMR091C NPL6 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YMR091C NPL6 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YMR091C NPL6 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YMR091C NPL6 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) fails to grow in 100% oxygen atmosphere 2 YMR091C NPL6 systematic mutation set Oxidative stress resistance decreased paraquat (0.5 mM) decreased growth in 0.5 mM paraquat 2 YMR091C NPL6 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) strong sensitivity 2 YMR091C NPL6 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YMR091C NPL6 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YMR091C NPL6 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YMR091C NPL6 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YMR091C NPL6 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YMR091C NPL6 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YMR097C MTG1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR097C MTG1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YMR097C MTG1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YMR097C MTG1 systematic mutation set Oxidative stress resistance decreased dioxygen (100%) decreased growth in 100% oxygen atmosphere 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YMR098C ATP25 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR098C ATP25 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YMR098C ATP25 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YMR098C ATP25 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YMR098C ATP25 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YMR098C ATP25 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YMR098C ATP25 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YMR152W YIM1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YMR152W YIM1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YMR152W YIM1 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YMR152W YIM1 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YMR152W YIM1 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YMR179W SPT21 competitive growth Competitive fitness decreased minimal medium 2 YMR179W SPT21 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR179W SPT21 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YMR179W SPT21 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YMR179W SPT21 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YMR179W SPT21 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YMR179W SPT21 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YMR179W SPT21 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YMR179W SPT21 systematic mutation set Telomere length decreased 2 YMR179W SPT21 systematic mutation set Telomere length decreased 2 YMR183C SSO2 competitive growth Competitive fitness decreased minimal medium 2 YMR183C SSO2 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YMR183C SSO2 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YMR183C SSO2 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YMR184W ADD37 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YMR205C PFK2 competitive growth Competitive fitness decreased minimal medium 2 YMR205C PFK2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR205C PFK2 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YMR205C PFK2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YMR205C PFK2 systematic mutation set Chitin deposition decreased 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) moderate sensitivity 2 YMR272C SCS7 competitive growth Competitive fitness decreased minimal medium 2 YMR272C SCS7 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YMR272C SCS7 "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "weak sensitivity, one relative fitness ratio below 0.92" 2 YMR272C SCS7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YMR272C SCS7 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YMR272C SCS7 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YMR272C SCS7 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YMR272C SCS7 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) weak sensitivity 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased cycloheximide (0.1 ug/ml) strong sensitivity 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) weak sensitivity 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YMR272C SCS7 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YMR307W GAS1 classical genetics Resistance to chemicals decreased Congo Red 2 YMR307W GAS1 classical genetics Resistance to chemicals decreased FK506 2 YMR307W GAS1 competitive growth Competitive fitness decreased minimal medium 2 YMR307W GAS1 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YMR307W GAS1 homozygous diploid Oxidative stress resistance decreased hydrogen peroxide (2 mM) 2 YMR307W GAS1 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YMR307W GAS1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YMR307W GAS1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Freeze-thaw resistance decreased "frozen at -25 deg C for 5 days, then thawed at 30 deg C for 15 min." 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) moderate growth defect 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 2 YMR307W GAS1 large-scale survey Resistance to chemicals decreased pyocyanin (75 μg/ml) 2 YMR307W GAS1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YMR307W GAS1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased Calcofluor White 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased cyclosporin A (100 ug/ml) moderate sensitivity 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased Echinacea extract 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased FK506 (2 ug/ml) moderate sensitivity 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YMR316C-A competitive growth Competitive fitness decreased minimal medium 2 YMR316C-A systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YNL021W HDA1 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 2 YNL021W HDA1 competitive growth Competitive fitness decreased minimal medium 2 YNL021W HDA1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YNL021W HDA1 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YNL021W HDA1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL021W HDA1 systematic mutation set Resistance to chemicals decreased fluconazole (15 ug/ml) weak sensitivity 2 YNL021W HDA1 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YNL055C POR1 classical genetics Apoptosis decreased increased resistance to apoptosis induced by Cu2+ 2 YNL055C POR1 classical genetics Survival rate in stationary phase decreased cells grown to stationary phase for 2 days at 30 deg C and then shifted to 37 deg C 100-1000 fold reduction in colony-forming potential after 16 days at 37 deg C 2 YNL055C POR1 classical genetics Survival rate in stationary phase decreased 2 YNL055C POR1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL055C POR1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YNL055C POR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YNL055C POR1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YNL055C POR1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YNL055C POR1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YNL055C POR1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL059C ARP5 classical genetics Killer toxin resistance decreased HM-1 killer toxin 2 YNL059C ARP5 classical genetics Killer toxin resistance decreased K1 killer toxin 2 YNL059C ARP5 classical genetics Killer toxin resistance decreased K28 killer toxin 2 YNL059C ARP5 classical genetics Metal resistance decreased zinc dichloride (6 mM) 2 YNL059C ARP5 classical genetics Resistance to chemicals decreased calcium dichloride (0.2 M) 2 YNL059C ARP5 classical genetics Resistance to chemicals decreased Echinocandin B (0.2 ug/ml) 2 YNL059C ARP5 classical genetics Resistance to chemicals decreased Papulacandin B (1 ug/ml) 2 YNL059C ARP5 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Acid pH resistance decreased moderate growth defect;pH 3.0 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) strong growth defect 2 YNL059C ARP5 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YNL059C ARP5 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YNL059C ARP5 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YNL059C ARP5 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YNL059C ARP5 systematic mutation set Oxidative stress resistance decreased hydrogen peroxide (4 mM) 2 YNL059C ARP5 systematic mutation set Oxidative stress resistance decreased linoleic acid hydroperoxide (0.2 mM) 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" no growth on YPD plus 2 ug/ml CTBT 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased formaldehyde (1.5 mM) 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YNL059C ARP5 systematic mutation set Toxin resistance decreased Ala-Eth dipeptide (0.1 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YNL059C ARP5 systematic mutation set Transposable element transposition decreased severe decrease in Ty1 mobility 2 YNL059C ARP5 systematic mutation set Transposable element transposition decreased Ty3 2 YNL076W MKS1 competitive growth Competitive fitness decreased minimal medium 2 YNL076W MKS1 "heterozygous diploid, competitive growth" Resistance to chemicals decreased 5-fluorouracil (19.2 uM) 2 YNL076W MKS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YNL076W MKS1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL076W MKS1 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YNL084C END3 classical genetics Metal resistance decreased chromium trioxide (200 uM) 2 YNL084C END3 classical genetics Resistance to chemicals decreased FK506 2 YNL084C END3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL084C END3 "homozygous diploid, large-scale survey" Cell size decreased small cell size; moderate defect 2 YNL084C END3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YNL084C END3 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YNL084C END3 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YNL084C END3 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YNL084C END3 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YNL094W APP1 competitive growth Competitive fitness decreased minimal medium 2 YNL094W APP1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YNL094W APP1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YNL094W APP1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YNL094W APP1 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YNL107W YAF9 classical genetics Osmotic stress resistance decreased cesium chloride (0.08 M) 2 YNL107W YAF9 classical genetics Osmotic stress resistance decreased lithium chloride (0.3 M) 2 YNL107W YAF9 classical genetics Prion formation decreased [PSI+] 2 YNL107W YAF9 classical genetics Resistance to chemicals decreased methyl methanesulfonate (0.03%) 2 YNL107W YAF9 classical genetics UV resistance decreased 2 YNL107W YAF9 competitive growth Competitive fitness decreased minimal medium 2 YNL107W YAF9 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL107W YAF9 "homozygous diploid, competitive growth" UV resistance decreased sensitive to both UVB and UVC irradiation 2 YNL107W YAF9 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 66% zymocin 2 YNL107W YAF9 "homozygous diploid, systematic mutation set" UV resistance decreased UV at 100 J/m2 moderate growth defect 2 YNL107W YAF9 systematic mutation set Metal resistance decreased manganese(2+) (12 mM) 2 YNL107W YAF9 systematic mutation set Oxidative stress resistance decreased linoleic acid hydroperoxide (0.2 mM) 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YNL107W YAF9 systematic mutation set Resistance to chemicals decreased rapamycin 2 YNL170W competitive growth Competitive fitness decreased minimal medium 2 YNL170W "heterozygous diploid, systematic mutation set" Resistance to chemicals decreased tenovin-6 (20 micromolar) authors note overlap with adjacent ORF PSD1 2 YNL170W "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YNL170W "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YNL170W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YNL170W "homozygous diploid, systematic mutation set" Sporulation decreased 2 YNL170W systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete medium) 2 YNL187W SWT21 competitive growth Competitive fitness decreased minimal medium 2 YNL187W SWT21 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YNL187W SWT21 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL199C GCR2 competitive growth Competitive fitness decreased minimal medium 2 YNL199C GCR2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL199C GCR2 "homozygous diploid, competitive growth" UV resistance decreased "weak sensitivity, one relative fitness ratio below 0.92" 2 YNL199C GCR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YNL199C GCR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YNL199C GCR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YNL199C GCR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) moderate growth defect 2 YNL199C GCR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YNL199C GCR2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased raffinose (2% raffinose/1 ug/ml antimycin A) moderate growth defect 2 YNL199C GCR2 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YNL199C GCR2 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YNL199C GCR2 systematic mutation set Resistance to chemicals decreased acetaldehyde (35 mM) 2 YNL199C GCR2 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YNL250W RAD50 classical genetics Gamma ray resistance decreased hypersensitive (less than 1% survival) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased 5-fluorouracil (1 ug/mL) elevated temperature (38 deg C) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased camptothecin (100 micromolar) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased chromium(6+) (50mM) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased cisplatin (80 uM) 10 fold reduction in viability 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased daunorubicin (10 uM) "1,000 fold reduction in viability" 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased ethylmethane sulfonate (0.3%) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased formaldehyde (1.5 mM) "very sensitive to chronic low-dose formaldehyde exposure, but only moderately sensitive to acute exposure (60 mM for 15 min)" 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased hydroxyurea (80 mM) <10% growth relative to untreated cells 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased menadione (0.1 mM) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased methyl methanesulfonate (0.01%) 2 YNL250W RAD50 classical genetics Resistance to chemicals decreased N-Methyl-N'-Nitro-N-Nitrosoguanidine (MNNG) (3 uM) "100,000 fold reduction in viability" 2 YNL250W RAD50 classical genetics UV resistance decreased 2 YNL250W RAD50 competitive growth Competitive fitness decreased minimal medium 2 YNL250W RAD50 homozygous diploid Resistance to chemicals decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM) 2 YNL250W RAD50 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL250W RAD50 "homozygous diploid, competitive growth" UV resistance decreased "high sensitivity, three or more relative fitness ratios below 0.92" 2 YNL250W RAD50 "homozygous diploid, large-scale survey" Resistance to chemicals decreased cisplatin (250 ug/ml) 2 YNL250W RAD50 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) no growth in the presence of 50 ug/ml doxorubicin; partial growth inhibition in the presence of 25 ug/ml doxorubicin 2 YNL250W RAD50 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is not suppressed by supplementation with 500 mM KCl 2 YNL250W RAD50 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YNL250W RAD50 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YNL250W RAD50 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased 5-fluorouracil (15 ug/ml) 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased camptothecin (15 ug/ml) strong sensitivity 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased "CTBT (4 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" no growth on YPD plus 4 ug/ml CTBT 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) hypersensitive (100-1000 fold decrease in survival relative to wildtype) 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased formaldehyde (1.5 mM) 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) strong sensitivity 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.035%) 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased propolis extract (0.5%) 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YNL250W RAD50 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) hypersensitive relative to wildtype 2 YNL250W RAD50 systematic mutation set Telomere length decreased 2 YNL250W RAD50 systematic mutation set Telomere length decreased 2 YNL296W classical genetics Metal resistance decreased zinc dichloride (6 mM) 2 YNL296W classical genetics Toxin resistance decreased "HD20Q (Huntingtin protein, exon1 containing 20 polyglutamine repeats)" 2 YNL296W competitive growth Competitive fitness decreased minimal medium 2 YNL296W homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YNL296W "homozygous diploid, competitive growth" UV resistance decreased "weak sensitivity, one relative fitness ratio below 0.92" 2 YNL296W "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.1 M LiCl) 2 YNL296W "homozygous diploid, systematic mutation set" Metal resistance decreased zinc sulfate (1000 uM) effective concentration (EC) 10 with growth inhibition greater than or equal to 80% 2 YNL296W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YNL296W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YNL296W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YNL296W "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YNL296W large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YNL296W large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YNL296W large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YNL296W systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YNL296W systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YNL296W systematic mutation set Resistance to chemicals decreased pyrrolidine dithiocarbamate (20 uM) 2 YNL296W systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YNL296W systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YNL296W systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) weak sensitivity 2 YNL296W systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 2 YNL297C MON2 classical genetics Metal resistance decreased zinc dichloride (6 mM) 2 YNL297C MON2 classical genetics Protein/peptide modification decreased "decreased levels of phosphorylated Snc1p, normally present on the membrane-localized pool" GFP-Snc1p 2 YNL297C MON2 competitive growth Competitive fitness decreased minimal medium 2 YNL297C MON2 homozygous diploid Chemical compound accumulation decreased lithium(1+) cells treated with 0.2 M LiCl intracellular content 2-3 times greater than the wild-type control 2 YNL297C MON2 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YNL297C MON2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased rubidium(1+) Rb+ influx is a measure of K+ influx 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.1 M LiCl) 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (0.075 ug/ml) hygromycin B sensitivity is suppressed by supplementation with 100 mM KCl 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (20 mM)" 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased tunicamycin (6 ug/ml) 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YNL297C MON2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YNL297C MON2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YNL297C MON2 systematic mutation set Resistance to chemicals decreased rapamycin 2 YNL297C MON2 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YNL297C MON2 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YNL297C MON2 systematic mutation set Resistance to chemicals decreased wortmannin 2 YOL035C large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YOL035C large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YOL108C INO4 competitive growth Competitive fitness decreased minimal medium 2 YOL108C INO4 homozygous diploid Chemical compound accumulation decreased tellurium atom growth in 0.1 mM K2TeO3 2 YOL108C INO4 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YOL108C INO4 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YOL108C INO4 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YOL108C INO4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YOL108C INO4 "homozygous diploid, systematic mutation set" Respiratory growth decreased glycerol 2 YOL108C INO4 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YOL108C INO4 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YOL108C INO4 systematic mutation set Competitive fitness decreased synthetic medium (synthetic complete medium) 2 YOL108C INO4 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YOL108C INO4 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YOL121C RPS19A competitive growth Competitive fitness decreased minimal medium 2 YOL121C RPS19A "heterozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YOL121C RPS19A "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YOL121C RPS19A large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YOL121C RPS19A large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YOL121C RPS19A large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YOR019W classical genetics Mitophagy decreased growth on lactate carbon source to post-log phase severe decrease 2 YOR019W large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YOR019W large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YOR069W VPS5 classical genetics Viability decreased nitrogen starvation 2 YOR069W VPS5 competitive growth Competitive fitness decreased minimal medium 2 YOR069W VPS5 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YOR069W VPS5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) moderate growth defect 2 YOR069W VPS5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YOR069W VPS5 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YOR069W VPS5 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YOR069W VPS5 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 2 YOR069W VPS5 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 2 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YOR132W VPS17 competitive growth Competitive fitness decreased minimal medium 2 YOR132W VPS17 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YOR132W VPS17 systematic mutation set Competitive fitness decreased synthetic medium (minimal +his/leu/ura medium) 2 YOR132W VPS17 systematic mutation set Protein/peptide modification decreased alkaline phosphatase (ALP) processing to mature form is decreased Pho8p (ALP) 2 YOR132W VPS17 systematic mutation set Protein/peptide modification decreased carboxypeptidase S (CPS) processing to mature form is decreased Cps1p (CPS) 2 YOR132W VPS17 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YOR132W VPS17 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YOR199W "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YOR199W "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YOR199W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YOR199W "homozygous diploid, systematic mutation set" Sporulation decreased 2 YOR199W "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) moderate growth defect 2 YOR199W "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) moderate growth defect 2 YOR199W large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YOR199W systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) sensitive (10-100 fold decreased survival relative to wildtype) 2 YOR199W systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) moderate sensitivity 2 YOR199W systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) strong sensitivity 2 YOR231W MKK1 competitive growth Competitive fitness decreased minimal medium 2 YOR231W MKK1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YOR231W MKK1 homozygous diploid Resistance to chemicals decreased mercaptoethanol (30 mM) 2 YOR231W MKK1 homozygous diploid Resistance to chemicals decreased tunicamycin (1 microgram/mL) 2 YOR231W MKK1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YOR290C SNF2 classical genetics Gamma ray resistance decreased sensitive (1-10% survival) 2 YOR290C SNF2 classical genetics Protein/peptide distribution decreased Reporter localizes to the ER in wildtype Pmp2GFP-KKTN 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased 6-azauracil (30 micrograms/ml) hypersensitive 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased camptothecin (10 uM) 10 fold reduction in viability 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased cisplatin (80 uM) 10 fold reduction in viability 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased daunorubicin (10 uM) "1,000 fold reduction in viability" 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased hydroxyurea (80 mM) <10% growth relative to untreated cells 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased mycophenolic acid (30 micrograms/ml) hypersensitive 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased N-Methyl-N'-Nitro-N-Nitrosoguanidine (MNNG) (3 uM) 10 fold reduction in viability 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased zymocin (45% (v/v)) 2 YOR290C SNF2 homozygous diploid Resistance to chemicals decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM) 2 YOR290C SNF2 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YOR290C SNF2 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YOR290C SNF2 "homozygous diploid, competitive growth" UV resistance decreased sensitive to both UVB and UVC irradiation 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) moderate growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased galactose (2% galactose/1 ug/ml antimycin A) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YOR290C SNF2 "homozygous diploid, systematic mutation set" UV resistance decreased UV at 100 J/m2 strong growth defect 2 YOR290C SNF2 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YOR290C SNF2 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YOR290C SNF2 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YOR290C SNF2 large-scale survey Resistance to chemicals decreased paromomycin (10 mg/ml) 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased "CTBT (2 ug/ml 7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine)" slow growth on YPD plus 2 ug/ml CTBT and no growth at 4 ug/ml 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) hypersensitive (100-1000 fold decrease in survival relative to wildtype) 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased formaldehyde (1.5 mM) 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased hydroxyurea (100 mM) moderate sensitivity 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased mycophenolic acid (30-100 micrograms/ml) hypersensitive 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased sulfanilamide (0.2 mg/ml) SMM liquid medium 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) strong sensitivity 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) moderate sensitivity 2 YOR290C SNF2 systematic mutation set Transposable element transposition decreased very severe decrease in Ty1 mobility 2 YOR292C classical genetics Toxin resistance decreased "HD20Q (Huntingtin protein, exon1 containing 20 polyglutamine repeats)" 2 YOR292C classical genetics Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 2 YOR292C large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YOR292C large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YOR292C systematic mutation set Resistance to chemicals decreased amiodarone (10 micromolar) 2 YOR292C systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) weak sensitivity 2 YOR292C systematic mutation set Toxin resistance decreased "HD53Q (Huntingtin protein, exon1 containing 53 polyglutamine repeats)" 2 YOR360C PDE2 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YOR360C PDE2 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YOR360C PDE2 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased "1,4-dithiothreitol (4 mM)" 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) hyper-susceptible mutant; fails to grow in the presence of 1.5 g/l quinine 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased quinine (1.5 g/l) mutant grows slowly in the presence of 1.5 g/l quinine 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased tunicamycin (2.5 ug/ml) 2 YOR360C PDE2 systematic mutation set Thermotolerance decreased "pretreatment at 37 deg C for 30 min, then heat shock at 50 deg C for 30 min" 2 YOR360C PDE2 systematic mutation set Transposable element transposition decreased moderate decrease in Ty1 mobility 2 YPL002C SNF8 classical genetics Metal resistance decreased cadmium(2+) (40 uM) 2 YPL002C SNF8 classical genetics Resistance to chemicals decreased sulfometuron (1 ug/ml) SC medium lacking Ile and Val 2 YPL002C SNF8 classical genetics Toxin resistance decreased Ala-Eth dipeptide (0.1-0.2 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YPL002C SNF8 homozygous diploid Sporulation efficiency decreased percent of cells forming 4-spored asci (less than 1%) 2 YPL002C SNF8 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL002C SNF8 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Hyperosmotic stress resistance decreased sodium chloride (1.2 M) moderate growth defect 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Ionic stress resistance decreased lithium(1+) (0.2 M LiCl) 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) moderate growth defect 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) moderate growth defect 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Sporulation efficiency decreased 2 YPL002C SNF8 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YPL002C SNF8 large-scale survey Resistance to chemicals decreased cadmium dichloride (50 uM) 2 YPL002C SNF8 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YPL002C SNF8 large-scale survey Resistance to chemicals decreased streptomycin (40 mg/ml) 2 YPL002C SNF8 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YPL002C SNF8 systematic mutation set Competitive fitness decreased nystatin (10 microM) 2 YPL002C SNF8 systematic mutation set Competitive fitness decreased sodium chloride (1 M NaCl) 2 YPL002C SNF8 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YPL002C SNF8 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased arsenite(3-) (0.75 - 1.0 mM) 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) moderate sensitivity 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased hydroxyurea 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased monensin (50 uM) slightly sensitive 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased rapamycin 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased sodium arsenite (400 uM) 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased sulfometuron methyl (3 ug/ml) weak sensitivity 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased tirapazamine (200 uM) sensitive relative to wildtype 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased tunicamycin (0.5 and 5 ug/ml) weak sensitivity 2 YPL002C SNF8 systematic mutation set Telomere length decreased 2 YPL002C SNF8 systematic mutation set Telomere length decreased 2 YPL002C SNF8 systematic mutation set Transposable element transposition decreased Ty3 2 YPL017C IRC15 competitive growth Competitive fitness decreased minimal medium 2 YPL017C IRC15 homozygous diploid Resistance to chemicals decreased benomyl (10 ug/ml) 2 YPL017C IRC15 homozygous diploid Resistance to chemicals decreased bortezomib (260 uM) Similar results were seen with PS-519 (8 uM) 2 YPL017C IRC15 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL017C IRC15 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YPL017C IRC15 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "1,4-dithiothreitol (12 mM)" 2 YPL029W SUV3 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YPL029W SUV3 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL029W SUV3 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YPL029W SUV3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YPL029W SUV3 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 33% zymocin;K. lactis zymocin 2 YPL029W SUV3 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YPL029W SUV3 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) strong growth defect 2 YPL029W SUV3 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YPL029W SUV3 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YPL051W ARL3 classical genetics Resistance to chemicals decreased Congo Red 2 YPL051W ARL3 classical genetics Toxin resistance decreased alpha-synuclein 2 YPL051W ARL3 competitive growth Competitive fitness decreased minimal medium 2 YPL051W ARL3 "homozygous diploid, competitive growth" Resistance to chemicals decreased BPS (75 uM bathophenanthrolinebisulfonic acid) 2 YPL051W ARL3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YPL051W ARL3 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YPL051W ARL3 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YPL051W ARL3 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YPL051W ARL3 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YPL051W ARL3 systematic mutation set Competitive fitness decreased alkaline medium (pH 8) 2 YPL051W ARL3 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YPL051W ARL3 systematic mutation set Resistance to chemicals decreased rapamycin 2 YPL051W ARL3 systematic mutation set Toxin resistance decreased alpha-synuclein 2 YPL057C SUR1 competitive growth Competitive fitness decreased minimal medium 2 YPL057C SUR1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YPL057C SUR1 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YPL057C SUR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YPL057C SUR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) moderate growth defect 2 YPL057C SUR1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YPL057C SUR1 large-scale survey Resistance to chemicals decreased neomycin (5.5 mg/ml) 2 YPL057C SUR1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YPL057C SUR1 systematic mutation set Endocytosis decreased "defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2" 2 YPL057C SUR1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YPL057C SUR1 systematic mutation set Resistance to chemicals decreased "hydrogen chloride (0.24% (w/v), pH 2.6)" 2 YPL057C SUR1 systematic mutation set Resistance to chemicals decreased "(S)-lactic acid (3.1% (w/v), pH2.9)" 2 YPL069C BTS1 classical genetics Protein/peptide modification decreased monensin (50 uM) reduced processing of Prc1p to mature form in the presence of monensin carboxypeptidase Y (Prc1p) 2 YPL069C BTS1 classical genetics Resistance to chemicals decreased FK506 2 YPL069C BTS1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL069C BTS1 "homozygous diploid, large-scale survey" Resistance to chemicals decreased lovastatin (150 micrograms/ml) 2 YPL069C BTS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YPL069C BTS1 "homozygous diploid, systematic mutation set" Sporulation decreased 2 YPL069C BTS1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YPL069C BTS1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YPL069C BTS1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YPL069C BTS1 systematic mutation set Alkaline pH resistance decreased "pH 6.8 to pH 7.5, in steps of 0.1-0.2 pH units" 2 YPL069C BTS1 systematic mutation set Resistance to chemicals decreased Calcofluor White 2 YPL069C BTS1 systematic mutation set Resistance to chemicals decreased cyclosporin A (100 ug/ml) moderate sensitivity 2 YPL069C BTS1 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YPL069C BTS1 systematic mutation set Resistance to chemicals decreased FK506 (2 ug/ml) moderate sensitivity 2 YPL069C BTS1 systematic mutation set Resistance to chemicals decreased monensin (50 uM) moderately sensitive 2 YPL073C competitive growth Competitive fitness decreased minimal medium 2 YPL073C systematic mutation set Toxin resistance decreased Ala-Eth dipeptide (0.1 uM) "cultured in minimal medium containing histidine, leucine, lysine and uracil" increased sensitivity in toxic dipeptide halo assay 2 YPL090C RPS6A classical genetics Cell size decreased 2 YPL090C RPS6A competitive growth Competitive fitness decreased minimal medium 2 YPL090C RPS6A "heterozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL090C RPS6A "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YPL090C RPS6A "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL090C RPS6A "homozygous diploid, systematic mutation set" Metal resistance decreased cadmium dichloride (55 uM) moderate growth defect 2 YPL090C RPS6A "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YPL090C RPS6A "homozygous diploid, systematic mutation set" Resistance to chemicals decreased calcium dichloride (0.7 M) strong growth defect 2 YPL090C RPS6A "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YPL090C RPS6A "homozygous diploid, systematic mutation set" Resistance to chemicals decreased "L-1,4-dithiothreitol (32 mM)" 2 YPL173W MRPL40 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YPL173W MRPL40 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL173W MRPL40 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Dessication resistance decreased pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth 2-fold or greater decreased survival after the treatment 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Toxin resistance decreased K. lactis zymocin;complete growth inhibition on exposure to 33% zymocin 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YPL173W MRPL40 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased lactate (2%) strong growth defect 2 YPL173W MRPL40 systematic mutation set Resistance to chemicals decreased "1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (1.5 mM)" 2 YPL173W MRPL40 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YPL180W TCO89 classical genetics Resistance to chemicals decreased L-canavanine (2 ug/ml) 2 YPL180W TCO89 classical genetics Resistance to chemicals decreased rapamycin moderate sensitivity 2 YPL180W TCO89 homozygous diploid Resistance to chemicals decreased tellurite (0.1 mM K2TeO3) 2 YPL180W TCO89 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL180W TCO89 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) moderate growth defect 2 YPL180W TCO89 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (25 ug/ml) no growth in the presence of 25 ug/ml doxorubicin 2 YPL180W TCO89 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium strong growth defect 2 YPL180W TCO89 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased rapamycin (0.1 ug/ml) strong growth defect 2 YPL180W TCO89 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YPL180W TCO89 systematic mutation set Resistance to chemicals decreased caffeine (0.15%) weak sensitivity 2 YPL180W TCO89 systematic mutation set Resistance to chemicals decreased doxorubicin (20 uM) slightly sensitive (2-10 fold decreased survival relative to wildtype) 2 YPL180W TCO89 systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YPL180W TCO89 systematic mutation set Resistance to chemicals decreased rapamycin (0.015 ug/ml) strong sensitivity 2 YPL187W MF(ALPHA)1 competitive growth Competitive fitness decreased minimal medium 2 YPL187W MF(ALPHA)1 "heterozygous diploid, competitive growth" Starvation resistance decreased 2 YPL213W LEA1 competitive growth Competitive fitness decreased minimal medium 2 YPL213W LEA1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPL213W LEA1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YPL213W LEA1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased caffeine (2 mg/ml) strong growth defect 2 YPL213W LEA1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased cycloheximide (0.18 ug/ml) strong growth defect 2 YPL213W LEA1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased ethanol (6%) YPD medium moderate growth defect 2 YPL213W LEA1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hygromycin B (50 ug/ml) strong growth defect 2 YPL213W LEA1 large-scale survey Resistance to chemicals decreased amitrole (22 mg/ml) 2 YPL213W LEA1 large-scale survey Resistance to chemicals decreased cycloheximide (45 ng/ml) 2 YPL213W LEA1 systematic mutation set Acid pH resistance decreased propionic acid (20 mM propionic acid) 2 YPL213W LEA1 systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YPL213W LEA1 systematic mutation set Resistance to chemicals decreased benomyl (15 ug/ml) weak sensitivity 2 YPL213W LEA1 systematic mutation set Resistance to chemicals decreased Calcofluor White 2 YPL213W LEA1 systematic mutation set Resistance to chemicals decreased oleate (0.1%) 2 YPL213W LEA1 systematic mutation set Resistance to chemicals decreased wortmannin (1.3 ug/ml) moderate sensitivity 2 YPR047W MSF1 "homozygous diploid, competitive growth" Competitive fitness decreased YPD medium 2 YPR047W MSF1 "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YPR047W MSF1 "homozygous diploid, competitive growth" Resistance to chemicals decreased elesclomol-Cu (300 nM) 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Chemical compound accumulation decreased glycogen 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased glycolaldehyde (0.01 mM) > 10% sensitivity relative to the wild-type (p<0.05) 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YPR047W MSF1 "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YPR047W MSF1 systematic mutation set Cell size decreased mutant is among the smallest 5% of haploid deletion strains 2 YPR123C competitive growth Competitive fitness decreased minimal medium 2 YPR123C "homozygous diploid, competitive growth" Resistance to chemicals decreased "2-phenyl-3-nitroso-imidazo[1,2-a]pyridine (9 uM)" 2 YPR123C "homozygous diploid, competitive growth" Resistance to chemicals decreased methyl methanesulfonate "moderate sensitivity, one relative fitness ratio below 0.88" 2 YPR123C "homozygous diploid, systematic mutation set" Dessication resistance decreased mutant displays greatly reduced growth in rich medium after exposure to air-drying stress for one day 2 YPR123C "homozygous diploid, systematic mutation set" Oxidative stress resistance decreased paraquat (1 mM) strong growth defect 2 YPR123C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased acrolein (5 mM) 2 YPR123C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased doxorubicin (50 ug/ml) slow growth in the presence of 50 ug/ml doxorubicin 2 YPR123C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased hydroxyurea (11.4 mg/ml) strong growth defect 2 YPR123C "homozygous diploid, systematic mutation set" Toxin resistance decreased complete growth inhibition on exposure to 66% zymocin;K. lactis zymocin 2 YPR123C "homozygous diploid, systematic mutation set" Utilization of carbon source decreased glycerol (3%) strong growth defect 2 YPR123C systematic mutation set Resistance to chemicals decreased "acetic acid (0.4% (w/v), pH 4.3)" 2 YPR123C systematic mutation set Resistance to chemicals decreased ethanol (8%) 2 YPR123C systematic mutation set Resistance to chemicals decreased methyl methanesulfonate 2 YBR189W RPS9B systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YBR194W AIM4 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YBR200W BEM1 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 2 YBR200W BEM1 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 2 YBR200W BEM1 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YCR084C TUP1 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YER087W AIM10 systematic mutation set Resistance to chemicals decreased "2,4-Diacetylphloroglucinol" 2 YER087W AIM10 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YHL019C APM2 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YHR041C SRB2 systematic mutation set Telomere length decreased 2 YIL035C CKA1 classical genetics Ionic stress resistance decreased sodium chloride (1.2 M) 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YDL020C RPN4 classical genetics Metal resistance decreased cadmium(2+) (50 uM cadmium dichloride) 2 YDL020C RPN4 classical genetics Protein activity decreased "decreased chymotrypsin-like (Suc-LLVY-AMC), trypsin-like (Boc-RLR-AMC) and caspase-like (Ac-nLPnLD-AMC) activities" proteasome holocomplex 2 YDL020C RPN4 classical genetics Protein/peptide accumulation decreased decreased abundance of proteasome core particle (CP; Pre10p and all CP) and regulatory particle (RP; Rpn5p and Rpn8p) subunits proteasome subunits 2 YDL020C RPN4 classical genetics Replicative lifespan decreased dietary restriction (reduced glucose concentration; 0.05%) partially rescues the lifespan reduction 2 YDL020C RPN4 classical genetics Resistance to chemicals decreased L-canavanine (3 ug/ml) 2 YDL020C RPN4 classical genetics Resistance to chemicals decreased mancozeb (1.1 mg/l) 2 YDL020C RPN4 classical genetics Resistance to chemicals decreased tunicamycin (0.5 ug/ml) 2 YDR136C VPS61 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YDR149C systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YDR159W SAC3 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YDR268W MSW1 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YDR320C SWA2 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YDR432W NPL3 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YDR456W NHX1 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 2 YDR456W NHX1 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 2 YDR456W NHX1 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 2 YGL071W AFT1 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 2 YGL071W AFT1 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 2 YGL071W AFT1 systematic mutation set Metal resistance decreased nickel(2+) (3 mM NiCl2) 2 YGL071W AFT1 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YGL143C MRF1 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YGL246C RAI1 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YJL188C BUD19 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YJR032W CPR7 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YJR033C RAV1 systematic mutation set Metal resistance decreased cobalt(2+) (2.5 mM CoCl2) 2 YJR033C RAV1 systematic mutation set Metal resistance decreased manganese(2+) (4 mM MnCl2) 2 YJR033C RAV1 systematic mutation set Metal resistance decreased nickel(2+) (3 mM NiCl2) 2 YJR033C RAV1 systematic mutation set Metal resistance decreased zinc(2+) (7 mM ZnCl2) 2 YJR033C RAV1 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YJR108W ABM1 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YLL002W RTT109 classical genetics Protein/peptide accumulation decreased Pho5p 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YLR039C RIC1 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YLR068W FYV7 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YMR097C MTG1 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YMR098C ATP25 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YMR152W YIM1 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YMR179W SPT21 systematic mutation set Resistance to chemicals decreased pentachlorophenol (0.156 mM) 2 YMR307W GAS1 classical genetics Resistance to chemicals decreased Calcofluor White 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YNL107W YAF9 classical genetics Resistance to chemicals decreased benomyl (10 ug/ml) 2 YNL107W YAF9 classical genetics Resistance to chemicals decreased hydroxyurea (175 mM) 2 YOL121C RPS19A systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YOR132W VPS17 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YOR199W systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased 4-chlorophenol (1 mM) 2 YOR360C PDE2 systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YPL002C SNF8 systematic mutation set Resistance to chemicals decreased neothyonidioside (10 uM) 2 YPL090C RPS6A systematic mutation set Resistance to chemicals decreased nickel sulfate 2 YPL173W MRPL40 systematic mutation set Resistance to chemicals decreased "2,4-dichlorophenol (0.3 mM)" 2 YAL013W DEP1 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YCL008C STP22 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YCR009C RVS161 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YCR009C RVS161 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YKL037W AIM26 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YKL113C RAD27 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YKL113C RAD27 systematic mutation set Resistance to chemicals decreased methanol (16%) 2 YDR149C systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YDR264C AKR1 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YGL071W AFT1 systematic mutation set Hyperosmotic stress resistance decreased sodium chloride (1 M) 2 YGL071W AFT1 systematic mutation set Oxidative stress resistance decreased hydrogen peroxide (5 mM) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased methanol (16%) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YGL167C PMR1 classical genetics Resistance to chemicals decreased cadmium chloride 2 YGL167C PMR1 competitive growth Competitive fitness decreased 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased methanol (16%) 2 YJR102C VPS25 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YLR025W SNF7 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased methanol (16%) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YMR077C VPS20 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased methanol (16%) 2 YMR205C PFK2 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YMR307W GAS1 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YNL055C POR1 classical genetics Respiratory metabolism decreased nonfermentable carbon source (2.5% glycerol) 2 YNL059C ARP5 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YPL017C IRC15 systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YPL073C systematic mutation set Resistance to chemicals decreased propan-1-ol (7%) 2 YPL180W TCO89 systematic mutation set Resistance to chemicals decreased ethanol (10%) 2 YBR289W SNF5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YCL008C STP22 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YCR009C RVS161 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YHR021C RPS27B "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YHR041C SRB2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YHR059W FYV4 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YHR178W STB5 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YKL113C RAD27 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YKR007W MEH1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YFR040W SAP155 homozygous diploid Resistance to chemicals decreased hygromycin B (0.1 mg/ml) 2 YDR149C "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YDR159W SAC3 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YDR174W HMO1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YDR264C AKR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YDR268W MSW1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YGL025C PGD1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YGL143C MRF1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YGL148W ARO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YGL223C COG1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YGL246C RAI1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YGR163W GTR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YJL188C BUD19 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YJR032W CPR7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YJR102C VPS25 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YJR118C ILM1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR025W SNF7 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR027C AAT2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR226W BUR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR322W VPS65 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR370C ARC18 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR417W VPS36 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YLR435W TSR2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YML121W GTR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YMR091C NPL6 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YMR183C SSO2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YMR205C PFK2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YMR307W GAS1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YNL055C POR1 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YNL296W "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YNL297C MON2 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YPL002C SNF8 "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YPL090C RPS6A "homozygous diploid, systematic mutation set" Resistance to chemicals decreased sorbate (2 mM) pH 4.5 2 YKL037W AIM26 classical genetics Autophagy decreased slight decrease; similar result seen in S288C strain background;autophagy assayed by delivery of cytoplasmic Pho8p to vacuole 2 YKL037W AIM26 classical genetics Mitophagy decreased mitophagy defects observed using three different assays in either S288C or SEY6210 background 2 YGL167C PMR1 classical genetics Mitophagy decreased mitophagy defects observed using two different assays in either S288C or SEY6210 background 2 YGL167C PMR1 classical genetics Resistance to chemicals decreased calcium(2+) (400 mM) 2 YOR019W classical genetics Mitophagy decreased mitophagy defects observed using three different assays in either S288C or SEY6210 background 2 YBR200W BEM1 classical genetics Invasive growth decreased 2 YCL008C STP22 classical genetics Biofilm formation decreased defective mat formation on low-density agar 2 YIL157C COA1 systematic mutation set Filamentous growth decreased 2 YKL113C RAD27 systematic mutation set Filamentous growth decreased greatly decreased 2 YKR010C TOF2 systematic mutation set Filamentous growth decreased greatly decreased 2 YDR268W MSW1 systematic mutation set Filamentous growth decreased greatly decreased 2 YDR422C SIP1 systematic mutation set Filamentous growth decreased 2 YJR102C VPS25 classical genetics Biofilm formation decreased defective mat formation on low-density agar 2 YLR025W SNF7 classical genetics Biofilm formation decreased defective mat formation on low-density agar 2 YLR417W VPS36 classical genetics Biofilm formation decreased defective mat formation on low-density agar 2 YML121W GTR1 systematic mutation set Filamentous growth decreased 2 YMR077C VPS20 classical genetics Biofilm formation decreased defective mat formation on low-density agar 2 YMR152W YIM1 systematic mutation set Filamentous growth decreased 2 YNL076W MKS1 classical genetics Resistance to chemicals decreased rapamycin (40 ng/ml) 2 YNL076W MKS1 systematic mutation set Filamentous growth decreased greatly decreased 2 YOR360C PDE2 systematic mutation set Filamentous growth decreased 2 YPL002C SNF8 classical genetics Biofilm formation decreased defective mat formation on low-density agar 2 YPL029W SUV3 systematic mutation set Filamentous growth decreased greatly decreased 2 YPL057C SUR1 systematic mutation set Filamentous growth decreased 2 YHR031C RRM3 classical genetics Protein/peptide accumulation decreased alpha-factor block release Sml1p levels remain low after even after bulk genome duplication Myc-Sml1p 2 YHR124W NDT80 homozygous diploid RNA accumulation decreased sporulation medium "induction of middle-sporulation gene (CLB1, CLB3, CLB4, CLB5, and CLB6) expression is absent" CLB1 mRNA 2 YHR124W NDT80 homozygous diploid Sporulation decreased 2 YIL073C SPO22 "homozygous diploid, systematic mutation set" Spore germination decreased 2 YHR031C RRM3 classical genetics Resistance to chemicals decreased hydroxyurea (200 mM) modestly sensitive 2 YHR154W RTT107 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YHR154W RTT107 classical genetics Resistance to chemicals decreased methyl methanesulfonate (0.032%) 2 YIL157C COA1 classical genetics Respiratory metabolism decreased 2 YFR040W SAP155 classical genetics Toxin resistance decreased zymocin 2 YDR174W HMO1 classical genetics Vegetative growth decreased 2 YDR272W GLO2 homozygous diploid Resistance to chemicals decreased methylglyoxal 2 YDR456W NHX1 classical genetics Resistance to chemicals decreased hygromycin B (30 micrograms/ml) 2 YGL066W SGF73 classical genetics Resistance to chemicals decreased hydroxyurea 2 YGL086W MAD1 classical genetics Resistance to chemicals decreased benomyl (7.5-12.5 micrograms/ml) continue to divide in microcolony assay 2 YGL167C PMR1 classical genetics Metal resistance decreased cadmium dichloride (0.02 mM) 2 YGL167C PMR1 classical genetics Resistance to chemicals decreased hydroxyurea 2 YGL167C PMR1 systematic mutation set Resistance to chemicals decreased amiodarone (7 uM) 2 YGL246C RAI1 systematic mutation set Resistance to chemicals decreased amiodarone (7 uM) 2 YGR252W GCN5 classical genetics Resistance to chemicals decreased benomyl (5 ug/ml) 2 YJL141C YAK1 classical genetics Protein/peptide modification decreased ethanol grown cells "levels of the slower-migrating, phosphorylated form are significantly reduced" HA-Bcy1p1-124 (amino acids 1-124) 2 YJL141C YAK1 classical genetics Protein/peptide modification decreased stationary phase cells "levels of the slower-migrating, phosphorylated form are significantly reduced" HA-Bcy1p1-124 (amino acids 1-124) 2 YLL002W RTT109 classical genetics Resistance to chemicals decreased camptothecin (14.4 uM) 2 YLL002W RTT109 classical genetics Resistance to chemicals decreased hydroxyurea (100 mM) 2 YLL002W RTT109 classical genetics Resistance to chemicals decreased methyl methanesulfonate (0.008%) 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased amiodarone (7 uM) 2 YNL055C POR1 classical genetics Acid pH resistance decreased acetic acid (180 mM) decreased viability after incubation with 180 mM acetic acid for 200 min 2 YNL055C POR1 classical genetics Oxidative stress resistance decreased diamide (16 mM) decreased viability after incubation with 16 mM diamide for 200 min 2 YNL055C POR1 classical genetics Oxidative stress resistance decreased hydrogen peroxide (3 mM) decreased viability after incubation with 3 mM H2O2 for 200 min 2 YOR360C PDE2 classical genetics Hyperosmotic stress resistance decreased sodium chloride (1 M) elevated temperature (37 deg C) 2 YOR360C PDE2 classical genetics Oxidative stress resistance decreased hydrogen peroxide (1.5 mM) elevated temperature (37 deg C) 2 YPL187W MF(ALPHA)1 classical genetics Mating efficiency decreased 2 YGL148W ARO2 classical genetics Resistance to chemicals decreased 2-phenylethanol (0.3%) 2 YBR036C CSG2 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YBR126C TPS1 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 2 YBR200W BEM1 classical genetics Mating efficiency decreased 2 YBR278W DPB3 classical genetics Resistance to chemicals decreased 4-aminofolic acid;sulfanilamide 2 YBR289W SNF5 classical genetics Resistance to chemicals decreased bleomycin A2 2 YBR289W SNF5 classical genetics Resistance to chemicals decreased hydroxyurea 2 YBR289W SNF5 classical genetics Resistance to chemicals decreased methyl methanesulfonate 2 YBR289W SNF5 classical genetics UV resistance decreased 2 YBR289W SNF5 systematic mutation set Alkaline pH resistance decreased calcium dichloride (60 mM) YPD medium;alkaline pH (7.5) growth defects at pH 7.5 in 60 mM calcium chloride - vma phenotype 2 YEL061C CIN8 classical genetics Resistance to chemicals decreased cincreasin (200 micromolar) 2 YHR012W VPS29 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 2 YHR178W STB5 classical genetics Resistance to chemicals decreased caffeine 2 YHR178W STB5 classical genetics Utilization of nitrogen source decreased "slow growth on media containing urea, GABA, serine, threonine, or proline as sole nitrogen source" 2 YHR178W STB5 classical genetics Vegetative growth decreased minimal media 2 YHR178W STB5 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YHR178W STB5 systematic mutation set Resistance to chemicals decreased cycloheximide (1 microgram/ml) 2 YIL035C CKA1 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YIL153W RRD1 classical genetics Ionic stress resistance decreased calcium(2+) 2 YIL153W RRD1 classical genetics Resistance to chemicals decreased Calcofluor White 2 YIL153W RRD1 classical genetics Resistance to chemicals decreased cycloheximide 2 YIL153W RRD1 classical genetics Resistance to chemicals decreased ketoconazole 2 YIL153W RRD1 classical genetics Resistance to chemicals decreased trisodium vanadate 2 YIL153W RRD1 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YIL157C COA1 classical genetics Respiratory metabolism decreased 2 YKL113C RAD27 classical genetics Resistance to chemicals decreased 4-aminofolic acid;sulfanilamide 2 YKR007W MEH1 classical genetics Resistance to chemicals decreased hygromycin B 2 YDL106C PHO2 systematic mutation set Alkaline pH resistance decreased calcium dichloride (60 mM) YPD medium;alkaline pH (7.5) growth defects at pH 7.5 in 60 mM calcium chloride - vma phenotype 2 YDR207C UME6 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YDR293C SSD1 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YDR320C SWA2 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YDR520C URC2 classical genetics Resistance to chemicals decreased caffeine 2 YGL025C PGD1 large-scale survey Resistance to chemicals decreased farnesol (1-5 microMolar) 2 YGL025C PGD1 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YGL066W SGF73 classical genetics Vegetative growth decreased media containing acetate or glycerol and ethanol as the carbon source or sc media lacking inositol 2 YGL071W AFT1 systematic mutation set Alkaline pH resistance decreased calcium dichloride (60 mM) alkaline pH (7.5);YPD medium growth defects at pH 7.5 in 60 mM calcium chloride - vma phenotype 2 YGL071W AFT1 systematic mutation set Metal resistance decreased zinc chloride (4 mM) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YGL071W AFT1 systematic mutation set Resistance to chemicals decreased cyclosporin A (150 ug/ml) 2 YGL148W ARO2 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YGL167C PMR1 classical genetics Resistance to chemicals decreased calcium(2+) (400 mM) 2 YGL167C PMR1 classical genetics Resistance to chemicals decreased magnesium(2+) (200 mM) 2 YGR163W GTR2 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 2 YGR252W GCN5 systematic mutation set Resistance to chemicals decreased methyl methanesulfonate (0.02% MMS) slightly sensitive 2 YJR033C RAV1 classical genetics Endocytosis decreased defective constitutive vacuolar degradation of Ste3p;decreased rate of trafficking from an early endocytic intermediate to the vacuole 2 YJR139C HOM6 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YLR025W SNF7 classical genetics Utilization of carbon source decreased glycerol (2%) 2 YLR025W SNF7 classical genetics Utilization of carbon source decreased sucrose (2%) anaerobic growth 2 YLR226W BUR2 systematic mutation set Small molecule transport decreased NBD-cholesterol 2 YLR322W VPS65 systematic mutation set Resistance to chemicals decreased 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YLR396C VPS33 systematic mutation set Resistance to chemicals decreased gentamycin C1 (64 micrograms/ml) 2 YLR417W VPS36 large-scale survey Resistance to chemicals decreased farnesol (1-5 microMolar) 2 YLR417W VPS36 systematic mutation set Autophagy decreased GFP-Atg8p 2 YLR417W VPS36 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 2 YMR097C MTG1 classical genetics Mitochondrial genome maintenance decreased 2 YMR184W ADD37 classical genetics Metal resistance decreased cadmium(2+) (15 uM) 2 YMR205C PFK2 classical genetics Chemical compound accumulation decreased "D-fructose 1,6-bisphosphate" 2 YNL084C END3 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YNL250W RAD50 classical genetics Spore germination decreased 2 YNL297C MON2 classical genetics Resistance to chemicals decreased brefeldin A (500 micrograms/ml) 2 YNL297C MON2 classical genetics Resistance to chemicals decreased monensin (25 micrograms/ml) 2 YOL121C RPS19A classical genetics Vegetative growth decreased 2 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased calcofluor white (50 ug/ml) 2 YOR069W VPS5 systematic mutation set Resistance to chemicals decreased ethanol (6% ethanol) 2 YOR231W MKK1 large-scale survey Resistance to chemicals decreased farnesol (1-5 microMolar) 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased bleomycin A2 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased hydroxyurea 2 YOR290C SNF2 classical genetics Resistance to chemicals decreased methyl methanesulfonate 2 YOR290C SNF2 classical genetics UV resistance decreased 2 YOR290C SNF2 systematic mutation set Resistance to chemicals decreased citric acid (400 mM) 2 YPL029W SUV3 large-scale survey Resistance to chemicals decreased farnesol (1-5 microMolar) 2 YPL173W MRPL40 large-scale survey Resistance to chemicals decreased farnesol (1-5 microMolar) 2 YPL180W TCO89 classical genetics Resistance to chemicals decreased lithium chloride (0.3 M) 2 YPL180W TCO89 classical genetics Resistance to chemicals decreased sodium chloride (1 M) 2 YIL153W RRD1 classical genetics Cell cycle progression in G1 phase decreased duration rapamycin (100 ng/ml) rapamycin induced G1 delay is absent 2 YLL002W RTT109 "homozygous diploid, systematic mutation set" Cell cycle progression in G1 phase decreased duration percent of G1 cells less than two standard deviations (20.77%) below wild type when when assayed by FACS 2 YNL250W RAD50 "homozygous diploid, systematic mutation set" Cell cycle progression in G1 phase decreased duration percent of G1 cells less than two standard deviations (20.77%) below wild type when when assayed by FACS 2 YAL013W DEP1 systematic mutation set Vegetative growth decreased rate 2 YBR126C TPS1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR126C TPS1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR156C SLI15 systematic mutation set Vegetative growth decreased rate 2 YBR189W RPS9B "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR189W RPS9B "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR189W RPS9B systematic mutation set Vegetative growth decreased rate 2 YBR194W AIM4 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR200W BEM1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR200W BEM1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YBR289W SNF5 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YBR289W SNF5 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YBR289W SNF5 systematic mutation set Vegetative growth decreased rate 2 YCL008C STP22 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YCL008C STP22 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YCR009C RVS161 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YCR009C RVS161 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YEL061C CIN8 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YEL061C CIN8 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YEL061C CIN8 systematic mutation set Vegetative growth decreased rate 2 YER087W AIM10 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YER087W AIM10 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YHR021C RPS27B "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YHR021C RPS27B "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YHR021C RPS27B systematic mutation set Vegetative growth decreased rate 2 YHR038W RRF1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YHR038W RRF1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YHR038W RRF1 systematic mutation set Vegetative growth decreased rate 2 YHR041C SRB2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YHR041C SRB2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YHR041C SRB2 systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YHR124W NDT80 systematic mutation set Vegetative growth decreased rate 2 YHR129C ARP1 systematic mutation set Vegetative growth decreased rate 2 YIL157C COA1 classical genetics Respiratory growth decreased rate 2 YIL157C COA1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YIL157C COA1 systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YIL157C COA1 systematic mutation set Vegetative growth decreased rate 2 YKL037W AIM26 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YKL037W AIM26 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YKL037W AIM26 systematic mutation set Vegetative growth decreased rate 2 YKL113C RAD27 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YKL113C RAD27 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YKR007W MEH1 systematic mutation set Vegetative growth decreased rate 2 YKR057W RPS21A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YKR057W RPS21A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YKR085C MRPL20 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YKR085C MRPL20 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YFR040W SAP155 systematic mutation set Vegetative growth decreased rate 2 YDL020C RPN4 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDL020C RPN4 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDL056W MBP1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDL056W MBP1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDL083C RPS16B "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDL083C RPS16B "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDL083C RPS16B systematic mutation set Vegetative growth decreased rate 2 YDL106C PHO2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDL106C PHO2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDL133W SRF1 systematic mutation set Vegetative growth decreased rate 2 YDR136C VPS61 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR136C VPS61 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR159W SAC3 systematic mutation set Vegetative growth decreased rate 2 YDR174W HMO1 classical genetics Vegetative growth decreased rate slight decrease 2 YDR174W HMO1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDR174W HMO1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDR174W HMO1 systematic mutation set Vegetative growth decreased rate 2 YDR207C UME6 systematic mutation set Vegetative growth decreased rate 2 YDR264C AKR1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDR264C AKR1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDR264C AKR1 systematic mutation set Vegetative growth decreased rate 2 YDR268W MSW1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR268W MSW1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR293C SSD1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR293C SSD1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR432W NPL3 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDR432W NPL3 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YDR432W NPL3 systematic mutation set Vegetative growth decreased rate 2 YDR456W NHX1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDR456W NHX1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL025C PGD1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL025C PGD1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL025C PGD1 systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YGL025C PGD1 systematic mutation set Vegetative growth decreased rate 2 YGL066W SGF73 systematic mutation set Vegetative growth decreased rate 2 YGL071W AFT1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL071W AFT1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL071W AFT1 systematic mutation set Vegetative growth decreased rate 2 YGL135W RPL1B "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL135W RPL1B "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL135W RPL1B systematic mutation set Vegetative growth decreased rate 2 YGL143C MRF1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL143C MRF1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL167C PMR1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL167C PMR1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL167C PMR1 systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YGL167C PMR1 systematic mutation set Vegetative growth decreased rate 2 YGL223C COG1 classical genetics Vegetative growth decreased rate 2 YGL223C COG1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL223C COG1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YGL246C RAI1 systematic mutation set Vegetative growth decreased rate 2 YGR163W GTR2 systematic mutation set Vegetative growth decreased rate 2 YGR252W GCN5 systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YGR252W GCN5 systematic mutation set Vegetative growth decreased rate 2 YJL188C BUD19 systematic mutation set Vegetative growth decreased rate 2 YJR032W CPR7 large-scale survey Respiratory growth decreased rate nonfermentable carbon source (2% glycerol) 2 YJR032W CPR7 systematic mutation set Vegetative growth decreased rate 2 YJR033C RAV1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YJR033C RAV1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YJR102C VPS25 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YJR102C VPS25 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YJR118C ILM1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YJR118C ILM1 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YJR118C ILM1 systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YJR139C HOM6 systematic mutation set Vegetative growth decreased rate 2 YLL002W RTT109 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLL002W RTT109 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR025W SNF7 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR025W SNF7 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR027C AAT2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR027C AAT2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR027C AAT2 systematic mutation set Vegetative growth decreased rate 2 YLR068W FYV7 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR068W FYV7 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR068W FYV7 systematic mutation set Vegetative growth decreased rate 2 YLR226W BUR2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR226W BUR2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR322W VPS65 systematic mutation set Vegetative growth decreased rate 2 YLR370C ARC18 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR370C ARC18 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR396C VPS33 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR396C VPS33 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR417W VPS36 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR417W VPS36 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YLR435W TSR2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR435W TSR2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YLR435W TSR2 systematic mutation set Vegetative growth decreased rate 2 YML121W GTR1 systematic mutation set Vegetative growth decreased rate 2 YMR077C VPS20 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YMR077C VPS20 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YMR077C VPS20 systematic mutation set Vegetative growth decreased rate 2 YMR091C NPL6 classical genetics Vegetative growth decreased rate elevated temperature (28 deg C) 2 YMR091C NPL6 systematic mutation set Vegetative growth decreased rate 2 YMR097C MTG1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YMR097C MTG1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YMR097C MTG1 systematic mutation set Vegetative growth decreased rate 2 YMR098C ATP25 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YMR098C ATP25 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YMR098C ATP25 systematic mutation set Vegetative growth decreased rate 2 YMR179W SPT21 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YMR179W SPT21 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YMR179W SPT21 systematic mutation set Vegetative growth decreased rate 2 YMR205C PFK2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YMR205C PFK2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YMR205C PFK2 systematic mutation set Vegetative growth decreased rate 2 YNL059C ARP5 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YNL059C ARP5 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YNL170W "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YNL170W "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YNL199C GCR2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YNL199C GCR2 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YNL199C GCR2 systematic mutation set Vegetative growth decreased rate 2 YNL250W RAD50 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YNL250W RAD50 "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YNL296W systematic mutation set Respiratory growth decreased rate glycerol carbon source 2 YNL297C MON2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YNL297C MON2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YOL121C RPS19A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YOL121C RPS19A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YOL121C RPS19A systematic mutation set Vegetative growth decreased rate 2 YOR199W "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YOR199W "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YOR290C SNF2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YOR290C SNF2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YOR290C SNF2 systematic mutation set Vegetative growth decreased rate 2 YOR360C PDE2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YOR360C PDE2 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL002C SNF8 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL002C SNF8 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL029W SUV3 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL029W SUV3 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL029W SUV3 systematic mutation set Vegetative growth decreased rate 2 YPL090C RPS6A classical genetics Growth in exponential phase decreased rate 2 YPL090C RPS6A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YPL090C RPS6A "homozygous diploid, competitive growth" Fermentative growth decreased rate YPD medium 2 YPL090C RPS6A systematic mutation set Vegetative growth decreased rate 2 YPL173W MRPL40 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL173W MRPL40 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPL173W MRPL40 systematic mutation set Vegetative growth decreased rate 2 YPL180W TCO89 systematic mutation set Vegetative growth decreased rate 2 YPL213W LEA1 systematic mutation set Vegetative growth decreased rate 2 YPR047W MSF1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPR047W MSF1 "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPR123C "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YPR123C "homozygous diploid, competitive growth" Respiratory growth decreased rate "glycerol, ethanol, lactate medium" 2 YDL020C RPN4 classical genetics Growth in exponential phase decreased rate 2 YGL167C PMR1 competitive growth Vegetative growth decreased rate 2 YHR021C RPS27B classical genetics Growth in exponential phase decreased rate YPGA 2 YGL135W RPL1B classical genetics Vegetative growth decreased rate 2 YJR032W CPR7 classical genetics Growth in exponential phase decreased rate 2 YGL135W RPL1B systematic mutation set Fermentative growth decreased rate 2 YGL148W ARO2 systematic mutation set Fermentative growth decreased rate 2 YJR139C HOM6 systematic mutation set Fermentative growth decreased rate 2 YLR226W BUR2 systematic mutation set Fermentative growth decreased rate