Supplementary Information for "Power graph compression reveals dominant relationships in genetic transcription networks" Sebastian E. Ahnert Cavendish Laboratory, University of Cambridge ============================= S. cerevisiae ============================= Set1a: MBP1 SWI4 SWI6 3 GO:0000083 2.05754260827808E-4 regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0005667 3.905502163342205E-4 transcription factor complex GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0031974 0.00513874920163652 membrane-enclosed lumen GO:0000082 0.00630252100840354 G1/S transition of mitotic cell cycle GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set1b: SPT21 SOK2 RBA50 MNN5 SNA2 CLA4 HCM1 MPT5 YGR109W-B TOS2 TOS3 YGR189C CAP1 PEX28 CLN1 SCW10 AGE1-B GIN4 PPN1 SKG6 PCL1 LSM4 YOX1 YMR279C GID8 PET54 GAT2 MCD1 MGA1 SWE1 YPR159W RNR1 PDR16 YGR109C YDR524W-A BUD9 tA(AGC)P AGE1 GIC1 LAC1 YGR109W-A GIC2 YHP1 GAS1 SWI4 FKS3 SPO20 47 GO:0022402 1.6859093753833607E-4 cell cycle process GO:0051301 1.8667585022907554E-4 cell division GO:0000131 3.02602994491707E-4 incipient cellular bud site GO:0007049 3.1625955712225306E-4 cell cycle GO:0031323 0.0016011148027448565 regulation of cellular metabolic process GO:0008360 0.001669837086867016 regulation of cell shape GO:0050794 0.0018215083583885709 regulation of cellular process GO:0006468 0.002104201496476225 protein phosphorylation GO:0050789 0.002303014197122903 regulation of biological process GO:0030427 0.0023566214034776234 site of polarized growth GO:0000003 0.002635027367923313 reproduction GO:0051726 0.003428899258869689 regulation of cell cycle GO:0007163 0.0034742504381599865 establishment or maintenance of cell polarity GO:0019222 0.004384457436058185 regulation of metabolic process GO:0060277 0.004524886877828076 negative regulation of transcription involved in G1 phase of mitotic cell cycle GO:0005933 0.004786957388831965 cellular bud GO:0016740 0.00507874112716429 transferase activity GO:0080090 0.005820928413403279 regulation of primary metabolic process GO:0033121 0.0064153969526866425 regulation of purine nucleotide catabolic process GO:0030478 0.006696832579185488 actin cap GO:0001191 0.006734006734006697 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription GO:0040007 0.007120912406203667 growth GO:0065009 0.008778470663626204 regulation of molecular function Set2a: STE12 DIG1 2 GO:0009373 4.925865720900028E-4 regulation of transcription by pheromones GO:0016049 7.537372806834754E-4 cell growth GO:0046019 9.447331128955547E-4 regulation of transcription from RNA polymerase II promoter by pheromones GO:0040007 0.0015492594070577977 growth GO:0045996 0.0037023324694557703 negative regulation of transcription by pheromones GO:0071444 0.006988120195667344 cellular response to pheromone GO:0046020 0.008503401360544272 negative regulation of transcription from RNA polymerase II promoter by pheromones Set2b: CWP1 SUT1 YEL1 SST2 YKL209C YCL056C PRM6 SRL3 SWE1 CLB1 VTI1 PRM3 ATG19 YKR041W CLA4 HYM1 GYP8 SIM1 SCW10 ACT1 FUS3 FUS1 ERG24 YGR189C DIG1 SVS1 tK(UUU)G2 GIC2 MSB2 SKT5 PRM1 BEM2 INP52 CST6 FKS3 MSG5 YLR332W YJU2 CHS1 GID8 CAM1 BUD8 ORC2 FIG1 GAT2 TEC1 SEC2 CIK1 RDI1 PEP1 FUS2 PCL2 tK(UUU)P YIL015W GFA1 SSF2 GPA1 SCH9 AFR1 BUD14 KAR4 CLB2 RAX2 ADE1 HAL1 UBC4 STE12 MNN5 STE2 YML046W RAD54 YKL096C-B tR(UCU)M1 PRM2 CUP9 tA(AGC)K2 CBT1 PRM4 78 GO:0051704 6.348446343965666E-14 multi-organism process GO:0030427 7.592086719478504E-11 site of polarized growth GO:0000003 2.647849922477638E-10 reproduction GO:0044463 1.7987747127401564E-7 cell projection part GO:0042995 1.7987747127401564E-7 cell projection GO:0022414 6.355971230303703E-7 reproductive process GO:0000131 1.1852615836110663E-6 incipient cellular bud site GO:0023052 1.735090320552783E-6 signaling GO:0048610 1.7551127830156246E-6 cellular process involved in reproduction GO:0032989 3.5812306247233787E-6 cellular component morphogenesis GO:0050790 4.195827466354087E-6 regulation of catalytic activity GO:0065009 5.902298637061936E-6 regulation of molecular function GO:0019236 7.747960773835867E-6 response to pheromone GO:0060089 8.956531884666151E-6 molecular transducer activity GO:0050789 1.3036556877088447E-5 regulation of biological process GO:0005933 2.730116009822895E-5 cellular bud GO:0071944 3.554661938147793E-5 cell periphery GO:0048583 3.8300775830663245E-5 regulation of response to stimulus GO:0007163 4.5360381511786084E-5 establishment or maintenance of cell polarity GO:0006022 4.9167249102448106E-5 aminoglycan metabolic process GO:0030234 5.028102771315977E-5 enzyme regulator activity GO:0071840 5.053765094606336E-5 cellular component organization or biogenesis GO:0048284 6.703391425809468E-5 organelle fusion GO:0010033 7.28678217750271E-5 response to organic substance GO:0044430 7.676265040358352E-5 cytoskeletal part GO:0065007 9.643447631347371E-5 biological regulation GO:0009966 9.672757412724681E-5 regulation of signal transduction GO:0022604 1.2340328990291868E-4 regulation of cell morphogenesis GO:0043085 1.3052518856359298E-4 positive regulation of catalytic activity GO:0006997 1.3875348398307652E-4 nucleus organization GO:0023051 1.5295073768123807E-4 regulation of signaling GO:0000749 1.7014807555802144E-4 response to pheromone involved in conjugation with cellular fusion GO:0044093 2.0267051468354883E-4 positive regulation of molecular function GO:0050794 2.705943299597409E-4 regulation of cellular process GO:0005856 3.188897504896101E-4 cytoskeleton GO:0050896 4.0191179242861006E-4 response to stimulus GO:0050793 4.932430484820183E-4 regulation of developmental process GO:0004872 6.263212021364234E-4 receptor activity GO:0046039 6.472294777971868E-4 GTP metabolic process GO:0019222 6.485996102446173E-4 regulation of metabolic process GO:0048869 7.285032818328132E-4 cellular developmental process GO:0032502 7.595335721286323E-4 developmental process GO:0007154 8.905731594896446E-4 cell communication GO:0051301 9.590810326104253E-4 cell division GO:0007165 0.0010786463286129025 signal transduction GO:0005887 0.001081146074337624 integral to plasma membrane GO:0032879 0.0010923460323321425 regulation of localization GO:0006184 0.001466501582746799 GTP catabolic process GO:0045996 0.0014778290873216616 negative regulation of transcription by pheromones GO:0006140 0.0014947906978427911 regulation of nucleotide metabolic process GO:0019953 0.001642291539134067 sexual reproduction GO:0008360 0.0017681563313088357 regulation of cell shape GO:0051716 0.0019583720765201824 cellular response to stimulus GO:0000742 0.002015564337876142 karyogamy involved in conjugation with cellular fusion GO:0046020 0.0021002850724008274 negative regulation of transcription from RNA polymerase II promoter by pheromones GO:0051345 0.0022042418551873498 positive regulation of hydrolase activity GO:0022603 0.0022751564563598544 regulation of anatomical structure morphogenesis GO:0032880 0.0023864294142476386 regulation of protein localization GO:0003924 0.002494066925056093 GTPase activity GO:0040007 0.0025623130341453216 growth GO:0005886 0.0026442303482975883 plasma membrane GO:0031226 0.0026457624241249147 intrinsic to plasma membrane GO:0000747 0.002701007096410808 conjugation with cellular fusion GO:0046019 0.002980374525778123 regulation of transcription from RNA polymerase II promoter by pheromones GO:0009373 0.0030645691884869488 regulation of transcription by pheromones GO:0030811 0.0031380609992314786 regulation of nucleotide catabolic process GO:0030031 0.0031826192167075276 cell projection assembly GO:0035382 0.003193033381712517 sterol transmembrane transport GO:0010008 0.0032471376064502006 endosome membrane GO:0051128 0.0032893864272352732 regulation of cellular component organization GO:0000910 0.0033871763039202904 cytokinesis GO:0030533 0.0036005465324704263 triplet codon-amino acid adaptor activity GO:0030030 0.003640468436178723 cell projection organization GO:0000755 0.0037258912916423217 cytogamy GO:0044459 0.004279354665719896 plasma membrane part GO:0006970 0.004376836618994373 response to osmotic stress GO:0032005 0.004647207739045877 signal transduction involved in conjugation with cellular fusion GO:0031323 0.004718113619098883 regulation of cellular metabolic process GO:0033121 0.006034919983039325 regulation of purine nucleotide catabolic process GO:0009371 0.00634808675718595 positive regulation of transcription by pheromones GO:0007329 0.006405856783344733 positive regulation of transcription from RNA polymerase II promoter by pheromones GO:0006397 0.006411108585739541 mRNA processing GO:0080090 0.006567779076187625 regulation of primary metabolic process GO:0048585 0.00695450214436519 negative regulation of response to stimulus GO:0051336 0.007019638600661363 regulation of hydrolase activity GO:0005819 0.007224655986808768 spindle GO:0051049 0.007566702694908065 regulation of transport GO:0007017 0.007577621639190674 microtubule-based process GO:0072665 0.007692307692307714 protein localization to vacuole GO:0000271 0.007893665548888916 polysaccharide biosynthetic process GO:0051293 0.007994186046511345 establishment of spindle localization GO:0070882 0.008986942781403696 cellular cell wall organization or biogenesis GO:0005681 0.009015215856823976 spliceosomal complex GO:0010927 0.009035832385998137 cellular component assembly involved in morphogenesis GO:0023057 0.009366261609063299 negative regulation of signaling GO:0000753 0.009446384688538877 cell morphogenesis involved in conjugation with cellular fusion GO:0060589 0.009780410866847078 nucleoside-triphosphatase regulator activity Set3a: MSN2 MSN4 2 GO:0051599 6.961364427426753E-5 response to hydrostatic pressure GO:0051409 6.961364427426753E-5 response to nitrosative stress GO:0009415 8.599931200549083E-5 response to water GO:0071500 1.4005602240896732E-4 cellular response to nitrosative stress GO:0071464 1.4005602240896732E-4 cellular response to hydrostatic pressure GO:0071462 1.903674090995587E-4 cellular response to water GO:0009409 2.0639834881319274E-4 response to cold GO:0007569 3.4097638888061987E-4 cell aging GO:0070417 4.2016806722690173E-4 cellular response to cold GO:0071241 0.001120238984316606 cellular response to inorganic substance GO:0007571 0.002347417840375607 age-dependent general metabolic decline GO:0071214 0.0027648611285658476 cellular response to abiotic stimulus GO:0006971 0.003076923076923083 hypotonic response GO:0045471 0.003389830508474593 response to ethanol GO:0034605 0.0035555555555555622 cellular response to heat GO:0032502 0.003999906105494663 developmental process GO:0043620 0.005193385267185533 regulation of DNA-dependent transcription in response to stress GO:0071470 0.005366726296958866 cellular response to osmotic stress GO:0036003 0.005656565656565672 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0071361 0.0056818181818181785 cellular response to ethanol GO:0042594 0.0059101654846328636 response to starvation GO:0009268 0.0069686411149826695 response to pH GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0009408 0.008255933952527736 response to heat GO:0009267 0.009352517985610884 cellular response to starvation Set3b: PST2 CUE4 PEX32 VOA1 SSA1 RPA14 LST8 SSA4 BMH1 HSP78 IST2 DDR48 HSP30 UPF3 TDH3 TPK1 RRI2 POG1 MCH4 TVP23 CCP1 GPH1 MRH1 SKM1 SIS1 tL(GAG)G RFC5 YOL114C STF2 POP7 HER1 CPR1 AMD1 HSP42 ASK1 TSL1-A MDH1 GRE3 tG(GCC)P2 GND2 PCL7 AFR1 LAP4 YML006C ISU2 YGR071C MRS4 SFK1 YPR159W GPI17 MMF1 ZWF1 HSP26 tE(UUC)E1 GPT2 YGP1 YPR159C-A CWP1 FMP48 tA(AGC)P PDC6 snR18 HSL1 SRC1 YKL096C-B ETP1 ROD1 TSL1 CTT1 YGR255C EFB1 GTO3-A 72 GO:0051082 0.0020638962488011337 unfolded protein binding GO:0005832 0.0022798332464823443 chaperonin-containing T-complex GO:0042744 0.0053837871096751614 hydrogen peroxide catabolic process GO:0031301 0.006889010794557284 integral to organelle membrane GO:0022838 0.006908115358819631 substrate-specific channel activity GO:0050661 0.007245048532685868 NADP binding GO:0072593 0.007564437879139093 reactive oxygen species metabolic process GO:0003723 0.007616661543681017 RNA binding GO:0006839 0.007773247913026506 mitochondrial transport GO:0031300 0.00823666241401718 intrinsic to organelle membrane GO:0031647 0.008503203261502586 regulation of protein stability GO:0000267 0.009844414862414566 cell fraction Set4a: RAP1 FHL1 2 GO:0032545 0.006079027355622685 CURI complex GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set4b: RTA1 RPL16B RPS17A RPL23B snR17a RPS17B SST2 RPS9B FPS1 RPL5 GFD2 RPL9A RKI1 RPS11B RPS5 RPS18B RPS29B BDF1 UTP6 RPS15 RPL1B TEF2 YML6 SLX8 RPS19A TEF1 ATG27 HMS2 FRE8 RPS6B YGK3 RPS6A RPL20B YGR149W RPS0B RPL20A MRM2 RPS4A RPS4B RPL36B RPL17A RPL17B RPS26A ADA2 YMR242W-A TKL2 MNL1 RPP2A RPS8B SRO9 RPL24B AST2 RPL2B RPL38 RPL8B SMC2-A RPL32 RPS18A ROX3 RPS0A RPL36A RPL25 YLR326W TSR1 NTC20 RPS7A RPS7B RPL33B RPL12B ASC1 YGL188C-A 71 GO:0030529 1.398138526895421E-37 ribonucleoprotein complex GO:0005840 5.459197607680238E-37 ribosome GO:0044391 4.922224618295351E-36 ribosomal subunit GO:0044445 1.956024311227342E-33 cytosolic part GO:0005198 2.568239260477821E-33 structural molecule activity GO:0006412 7.344942735806687E-23 translation GO:0005829 2.1000213946324026E-20 cytosol GO:0043228 9.371591820998495E-19 non-membrane-bounded organelle GO:0043232 9.371591820998495E-19 intracellular non-membrane-bounded organelle GO:0015934 7.138380299591246E-17 large ribosomal subunit GO:0015935 6.484943356962244E-16 small ribosomal subunit GO:0032991 2.9423502303099434E-14 macromolecular complex GO:0019538 6.43946853988765E-13 protein metabolic process GO:0002181 3.650711727154453E-12 cytoplasmic translation GO:0071843 3.4376675794705206E-10 cellular component biogenesis at cellular level GO:0022626 6.343891079230831E-10 cytosolic ribosome GO:0044267 1.0773098152391232E-9 cellular protein metabolic process GO:0003735 1.5243507537981882E-9 structural constituent of ribosome GO:0051236 2.3557108934963315E-9 establishment of RNA localization GO:0070925 7.960816229673187E-9 organelle assembly GO:0044446 8.481094639067143E-9 intracellular organelle part GO:0010467 2.9758729419502072E-8 gene expression GO:0009059 3.692106363525212E-8 macromolecule biosynthetic process GO:0015931 3.782645067090506E-8 nucleobase-containing compound transport GO:0034645 1.0620314170734931E-7 cellular macromolecule biosynthetic process GO:0044422 1.753014798942373E-7 organelle part GO:0006403 1.7868455644454054E-7 RNA localization GO:0044085 1.2781261805833296E-6 cellular component biogenesis GO:0044237 2.6727754511580903E-6 cellular metabolic process GO:0044260 3.3780086367995746E-6 cellular macromolecule metabolic process GO:0034660 3.607436717090877E-6 ncRNA metabolic process GO:0043170 6.588060081906336E-6 macromolecule metabolic process GO:0051169 2.6072478518416017E-5 nuclear transport GO:0071826 4.548981345045438E-5 ribonucleoprotein complex subunit organization GO:0090305 7.660802360838922E-5 nucleic acid phosphodiester bond hydrolysis GO:0044444 9.327990829387003E-5 cytoplasmic part GO:0003723 1.3509103807024254E-4 RNA binding GO:0008152 1.8150682455812442E-4 metabolic process GO:0042274 3.824621159257294E-4 ribosomal small subunit biogenesis GO:0044249 8.614539696767808E-4 cellular biosynthetic process GO:0009058 9.531138003089781E-4 biosynthetic process GO:0046907 0.0014502996874848353 intracellular transport GO:0022613 0.001922947783897379 ribonucleoprotein complex biogenesis GO:0051649 0.0020956983494230252 establishment of localization in cell GO:0043229 0.0027296332595321497 intracellular organelle GO:0033036 0.005262154010523616 macromolecule localization GO:0043933 0.005288467060309872 macromolecular complex subunit organization GO:0016072 0.0059509430101180386 rRNA metabolic process GO:0006450 0.007654735000364369 regulation of translational fidelity GO:0006740 0.00812032766170356 NADPH regeneration Set5a: FKH1 FKH2 2 GO:0000117 1.0287713041390398E-4 regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0034243 2.7956388034664826E-4 regulation of transcription elongation from RNA polymerase II promoter GO:0032784 2.9264010144855744E-4 regulation of transcription elongation, DNA-dependent GO:0001558 4.610875078220663E-4 regulation of cell growth GO:0040008 5.245137320609129E-4 regulation of growth GO:0051090 5.958291956305599E-4 regulation of sequence-specific DNA binding transcription factor activity GO:0030308 6.939625260235604E-4 negative regulation of cell growth GO:0090282 7.166746297181001E-4 positive regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0000114 7.201399128973288E-4 regulation of transcription involved in G1 phase of mitotic cell cycle GO:0016049 7.537372806834754E-4 cell growth GO:0016458 8.67396076977019E-4 gene silencing GO:0045926 9.578544061301818E-4 negative regulation of growth GO:0060968 0.0013068610203567448 regulation of gene silencing GO:0040007 0.0015492594070577977 growth GO:0035326 0.0017307026652821546 enhancer binding GO:0001158 0.0017633574325516535 enhancer sequence-specific DNA binding GO:0006354 0.001937984496123857 transcription elongation, DNA-dependent GO:0006368 0.002315963606285996 transcription elongation from RNA polymerase II promoter GO:0031935 0.003842175262302035 regulation of chromatin silencing GO:0060277 0.004524886877828076 negative regulation of transcription involved in G1 phase of mitotic cell cycle GO:0065009 0.00457892224752647 regulation of molecular function GO:0000980 0.00466200466200465 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0005667 0.005628517823639318 transcription factor complex GO:0003705 0.006734006734006697 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity GO:0051128 0.00763425380622143 regulation of cellular component organization GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set5b: TEL2 IDI1 PNP1 RSP5 KIP2 HTS1 CLB2 YCR075W-A VTI1 CLB4 PDS1 HHT1 BDF1 RIM4 CDC39 SSO2 ECM33 ADD37 HOS3 ESP1 CTS1 SCW11 DSE1 YHP1 VAC17 RKM3 MSH3 YNL176C SLM4 BUD4 NST1 YBR139W BUD8 YDR115W tK(UUU)P CIK1 ECM19-A HHF1 YAP6 AMN1 ARP7 RNR1 SPB1 YBR138C ERS1 JSN1 ICS2 CDS1 DIN7 tA(AGC)L DBF2 CHA1 YLR257W MK22 GLN1 PPN1 SBE22 SPC24 58 GO:0007049 1.6399880957430835E-5 cell cycle GO:0022402 9.67733657788173E-5 cell cycle process GO:0051656 4.8096096427174573E-4 establishment of organelle localization GO:0005815 5.805588706828672E-4 microtubule organizing center GO:0032886 6.341471458013161E-4 regulation of microtubule-based process GO:0010008 8.995956522608601E-4 endosome membrane GO:0051301 9.699147713884555E-4 cell division GO:0007017 9.760383220205138E-4 microtubule-based process GO:0005819 0.001302705839989827 spindle GO:0016090 0.0013169446883230993 prenol metabolic process GO:0048285 0.001981304773448638 organelle fission GO:0044440 0.0029731861434048427 endosomal part GO:0044430 0.004187009085678255 cytoskeletal part GO:0005933 0.0043410010206153555 cellular bud GO:0006333 0.004634147772499287 chromatin assembly or disassembly GO:0033043 0.00507829334785959 regulation of organelle organization GO:0015630 0.0055524920237887 microtubule cytoskeleton GO:0016091 0.0056818181818181785 prenol biosynthetic process GO:0000786 0.006993006993006884 nucleosome GO:0005881 0.0072735975284694 cytoplasmic microtubule GO:0051640 0.0073352508474726534 organelle localization GO:0003774 0.007998357764106321 motor activity GO:0008299 0.008470403069560832 isoprenoid biosynthetic process GO:0006996 0.00937164305241524 organelle organization GO:0034728 0.009485674751505335 nucleosome organization Set6a: PHD1 SOK2 2 GO:0016049 7.537372806834754E-4 cell growth GO:0040007 0.0015492594070577977 growth GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set6b: YER034W USV1 RAD16 MSN4 SOK2 UTR2 VHR1 snR3 RBA50 RPS3 AGE1 IZH3 TPO2 SNA2 CIN5 ZRG8 RHO3 YBR071W PRR2 RHO5 APT2 YPR013C CPR8 SCW10 SIT4 AGE1-B SPO20 YKL063C RPI1 GAC1 GID8 RSF2 GAT2 SET4 MGA1 ALG14 YBL029C-A SCW4 PET9 DFG16 FLO10 HAP4 CYC8 YPR063C YDR524W-A ROX1 KTI12 CUP9 CBF2 GIC2 STP4 ACA1 SPO73 FKS3 YBL029W 55 GO:0031323 5.31511641393451E-4 regulation of cellular metabolic process GO:0016757 0.0010136658831846987 transferase activity, transferring glycosyl groups GO:0050794 0.001029885194087075 regulation of cellular process GO:0009889 0.0012395190524723122 regulation of biosynthetic process GO:0051171 0.0019772511996760415 regulation of nitrogen compound metabolic process GO:0031326 0.0026222173106099345 regulation of cellular biosynthetic process GO:0032774 0.0026403376794799016 RNA biosynthetic process GO:0051051 0.002716295434753291 negative regulation of transport GO:0019222 0.002772068719104643 regulation of metabolic process GO:0051049 0.0035600781986651437 regulation of transport GO:0071555 0.003979842086121689 cell wall organization GO:0015833 0.004100523126851024 peptide transport GO:0045229 0.004454392563773519 external encapsulating structure organization GO:0035950 0.005196032120926206 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter GO:0080090 0.005820928413403279 regulation of primary metabolic process GO:0003677 0.008130845032175855 DNA binding GO:0035952 0.008503401360544198 negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter GO:0019219 0.008663528702375042 regulation of nucleobase-containing compound metabolic process GO:0071554 0.00971492559855589 cell wall organization or biogenesis GO:0010468 0.009835218461992964 regulation of gene expression Set7a: MSN2 ROX1 SOK2 ACE2 SKN7 ASH1 NDD1 7 GO:0001071 2.868711752705094E-6 nucleic acid binding transcription factor activity GO:0050789 3.5055379734817737E-4 regulation of biological process GO:0031323 4.307304007614707E-4 regulation of cellular metabolic process GO:0050794 5.624123299697319E-4 regulation of cellular process GO:0019222 5.954200545511292E-4 regulation of metabolic process GO:0080090 6.567367848695359E-4 regulation of primary metabolic process GO:0065007 7.301058499006774E-4 biological regulation GO:0032774 0.0013061843385543882 RNA biosynthetic process GO:0051171 0.0014929739897344366 regulation of nitrogen compound metabolic process GO:0009889 0.0017628397040291878 regulation of biosynthetic process GO:0060255 0.0023769385322563942 regulation of macromolecule metabolic process GO:0001067 0.0025289094976635156 regulatory region nucleic acid binding GO:0031326 0.00257560631144518 regulation of cellular biosynthetic process GO:0019219 0.004417604191566779 regulation of nucleobase-containing compound metabolic process GO:0048518 0.005243928072870034 positive regulation of biological process GO:0006351 0.007810657506841606 transcription, DNA-dependent GO:0048522 0.008183874987613145 positive regulation of cellular process GO:0009059 0.009786451754017909 macromolecule biosynthetic process Set7b: PMC1 YDR524W-A AGE1 YGL007C-A RBA50 PMA1 PMC1-A SNA2 AGE1-B 9 Set8a: YAP6 CIN5 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set8b: YPR148C SBP1 MMT1 SOK2 SUN4 SMP1 tD(GUC)K RPS3 HSP30 KEL2 TDH3 POG1 APT2 RHO5 SMP1-A HMS2 YPR013C VTC2 SPO20 RPS4A YPC1 YIR018C-A NCE102 GAC1 MIG3 YHB1 MGA1 YKR039W HAP4 YPR063C YEA6 ROX1 KTI12 PHD1 PHO81 ACA1 SPO73 YPR127W YKR038C 39 GO:0060255 5.899911313186182E-4 regulation of macromolecule metabolic process GO:0080090 7.510875018045362E-4 regulation of primary metabolic process GO:0031323 0.0012762521129937516 regulation of cellular metabolic process GO:0050794 0.0030551683875336263 regulation of cellular process GO:0042326 0.0030864197530864647 negative regulation of phosphorylation GO:0001071 0.004577912269471574 nucleic acid binding transcription factor activity GO:0051171 0.005370435218284784 regulation of nitrogen compound metabolic process GO:0045936 0.009640259232988594 negative regulation of phosphate metabolic process Set9a: CBF1 YOR344C 2 GO:0044262 0.007859271080281276 cellular carbohydrate metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set9b: BOI2 ACP1 PUT3 YMR196W RSP5 BMH1 MNN5 TDH2 BRE5 MET22 ATM1 HRR25 NCP1 DSE1 AZR1 SRB2 MET10 PGC1 ATP3 ABP1 ATP7 HSV2 SWE1 IML1 MET3 DPH2 MET5 PRS2 DRS2 UBC6 YCR087C-A CSL4 GAR1 33 GO:0044272 3.091806637535544E-4 sulfur compound biosynthetic process GO:0016820 4.330283556605311E-4 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0043412 4.680813732615763E-4 macromolecule modification GO:0044283 8.504147593117464E-4 small molecule biosynthetic process GO:0009337 9.517649611305526E-4 sulfite reductase complex (NADPH) GO:0019904 0.0010847347863922369 protein domain specific binding GO:0006790 0.0017031933682750584 sulfur compound metabolic process GO:0006464 0.00354404757874505 protein modification process GO:0060627 0.004303455713107424 regulation of vesicle-mediated transport GO:0043176 0.006492589621869964 amine binding GO:0031406 0.006492589621869964 carboxylic acid binding GO:0007010 0.007326149299571146 cytoskeleton organization GO:0016053 0.00742961441271393 organic acid biosynthetic process GO:0009067 0.00967585873246247 aspartate family amino acid biosynthetic process GO:0032386 0.009815304037154351 regulation of intracellular transport Set10a: RCS1 AFT2 2 Set10b: LYP1 HMX1 ALP1 ZWF1 SDS23 MMT1 LAP4 FAA1 CCC2 ATX1 COT1 YNL260C HER1 FTH1 GTS1 OLE1 MND1 LSM5 COT1-A YLR177W ISU2 ISU1 MRS4 PRB1 AFT1 YPR063C ROX1 RFX1 HSL1 ENT2 FTR1 SUE1 GIP3 33 GO:0019725 4.434390377497606E-6 cellular homeostasis GO:0055085 0.0013346241284004476 transmembrane transport GO:0065008 0.0020275741228694645 regulation of biological quality GO:0051186 0.002476424041548503 cofactor metabolic process GO:0005215 0.002910466022730542 transporter activity GO:0030001 0.003074037080909792 metal ion transport GO:0051234 0.004233696631470292 establishment of localization GO:0034755 0.0048914219256064135 iron ion transmembrane transport GO:0006811 0.005103091400024292 ion transport GO:0061024 0.007105264666629162 membrane organization GO:0033573 0.007692307692307591 high affinity iron permease complex GO:0051179 0.008312848424983922 localization Set11a: GCN4 RTG3 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set11b: ICY2 UGA3 MRPS17 VHR1 YAP1801 COX9 SPO75 GLT1 YAH1 YMR1 YHR162W ARO1 FMP48 GCV2 YHR071W ORC3 HIS4 ISU1 HIS7 PDR8 BOP2 ARG1 ARG3 IDP1 CPA2 ARG5,6 GIP3 VMA13-A GTO3-A 29 GO:0006520 1.2587011769469925E-6 cellular amino acid metabolic process GO:0044271 1.1002875965612445E-5 cellular nitrogen compound biosynthetic process GO:0042180 1.848419335644992E-5 cellular ketone metabolic process GO:0044106 2.2482456070426033E-5 cellular amine metabolic process GO:0009308 7.653186600639498E-5 amine metabolic process GO:0006082 8.603894217784418E-5 organic acid metabolic process GO:0016053 1.1007093221321662E-4 organic acid biosynthetic process GO:0009084 6.025855398191824E-4 glutamine family amino acid biosynthetic process GO:0044283 8.504147593117464E-4 small molecule biosynthetic process GO:0005759 8.951352767508243E-4 mitochondrial matrix GO:0005739 0.0015458705592815778 mitochondrion GO:0016491 0.0029952974932914676 oxidoreductase activity GO:0009064 0.003607259632718307 glutamine family amino acid metabolic process GO:0051287 0.004963890448834155 NAD binding GO:0006547 0.00718825766264036 histidine metabolic process GO:0051540 0.007749125590817559 metal cluster binding Set12a: SKN7 SUT1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0034764 0.008510638297871676 positive regulation of transmembrane transport Set12b: YPR148C USV1 MSN4 CCW12 ECM4 SOK2 RPS3 RMI1 RHO3 OLE1 RHO5 YLR113W SPO20 YKL063C RPI1 NCE102 YKR075C GID8 GAT2 SET4 MGA1 ADH3 HAP4 SDS23 KTI12 ISF1 SKS1 27 GO:0019222 0.0052653054693813164 regulation of metabolic process GO:0007154 0.00872595777531953 cell communication GO:0050789 0.009663820336922323 regulation of biological process Set13a: INO4 INO2 2 GO:0019637 0.0010752657584745687 organophosphate metabolic process GO:0008654 0.0019415985572312402 phospholipid biosynthetic process GO:0044255 0.003661258837925632 cellular lipid metabolic process GO:0006629 0.006809315521930216 lipid metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0008610 0.009269356597604242 lipid biosynthetic process Set13b: snR17a ITR1 YAK1 KEL2 RKM3 FAA1 RPB4 COT1 PSD1 KNH1 ADO1 UBX6 FAS1 SOD1 FAS2 COT1-A SAH1 PWP2 TIM23 INO1 RPL33B SRO77 CDS1 SWI5 EKI1 ACC1 26 GO:0044255 7.873854578392987E-6 cellular lipid metabolic process GO:0006629 8.378201203731517E-5 lipid metabolic process GO:0008610 1.1037033291044543E-4 lipid biosynthetic process GO:0005835 3.256904637832354E-4 fatty acid synthase complex GO:0008654 0.0017139857358346462 phospholipid biosynthetic process GO:0019637 0.00333563420521688 organophosphate metabolic process GO:0034471 0.00466200466200465 ncRNA 5'-end processing GO:0045017 0.004921165891329846 glycerolipid biosynthetic process GO:0031369 0.005494505494505476 translation initiation factor binding GO:0044429 0.006681372602540711 mitochondrial part GO:0042439 0.007519945031873874 ethanolamine-containing compound metabolic process GO:0051091 0.008064516129032091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0000966 0.008395953150581377 RNA 5'-end processing GO:0005739 0.009617512171009156 mitochondrion GO:0032787 0.009734866639957165 monocarboxylic acid metabolic process Set14a: CBF1 ABF1 2 GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set14b: RPN4 PUT3 MSH3 RSP5 KTR1 VTI1 BET3 CDC39 ULP2 VTC1 SMX2 FLC2 YER071C NCE103 LSM4 ATP7 IDH1 ACS1 CIK1 LPD1 SKY1 IML1 MET1 MET5 DSE1 NUP1 GUA1 BCY1 SWI4 29 GO:0016208 0.0012903225806450956 AMP binding GO:0032991 0.0019540308201642575 macromolecular complex GO:0016071 0.0046129437323842466 mRNA metabolic process GO:0051050 0.0070636957619000735 positive regulation of transport GO:0006082 0.007103089190682496 organic acid metabolic process GO:0044248 0.00761171892613376 cellular catabolic process GO:0042180 0.008826596853900564 cellular ketone metabolic process Set15a: SWI5 ACE2 2 GO:0000114 7.201399128973288E-4 regulation of transcription involved in G1 phase of mitotic cell cycle GO:2001041 0.0057803468208086255 regulation of cytokinetic cell separation involved in cell cycle cytokinesis GO:2001043 0.0073529411764705266 positive regulation of cytokinetic cell separation involved in cell cycle cytokinesis Set15b: CUE4 RPA14 BMH1 EGT2 RUP1 MDJ2 SFL1 TPM1 CTS1 SCW11 CPR1 TSL1-A YJL160C PCL2 BUD9 HSP150 AMN1 NIS1 AIM38 ICS2 TSL1 GTO3-A 22 GO:0005933 7.029425313752066E-5 cellular bud GO:0051301 8.590960207353504E-5 cell division GO:0005576 2.3506550264770673E-4 extracellular region GO:0030312 3.7325469259151897E-4 external encapsulating structure GO:0022402 0.0013517889848945223 cell cycle process GO:0000910 0.0018809009932791217 cytokinesis GO:0071944 0.0022013230860774254 cell periphery GO:0051726 0.002877934217089799 regulation of cell cycle GO:0007049 0.0038833573959959496 cell cycle GO:0006022 0.004271548436308276 aminoglycan metabolic process GO:0005199 0.004516711833784948 structural constituent of cell wall GO:0005515 0.005487092127784048 protein binding GO:0016798 0.006705163460440222 hydrolase activity, acting on glycosyl bonds GO:0007163 0.006948831373018142 establishment or maintenance of cell polarity GO:0030427 0.007074507488771542 site of polarized growth GO:0016049 0.0085850220942885 cell growth GO:0032506 0.009481895252457701 cytokinetic process Set16a: NDD1 MCM1 FKH2 3 GO:0000117 3.077740818216149E-4 regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0090282 7.166746297181001E-4 positive regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0007049 0.002854576561163024 cell cycle GO:0000988 0.004331065137782144 protein binding transcription factor activity Set16b: YNL058C ALK1 BUD4 UTH1 tK(UUU)P SPO12 CLB2 IRC8 JSN1 OCA2 SWI5 EKI1 MTC6 13 GO:0007049 9.820901996504656E-4 cell cycle GO:0022402 0.003485425498305914 cell cycle process GO:0051654 0.008695652173913082 establishment of mitochondrion localization Set17a: YAP7 YAP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set17b: TRX2 YNL134C LSB6 ADH6 SOD1 OYE3 DRE2 YHB1 GLR1 DAP1 CCS1 IBA57 MRS4 ADO1 RPL10 BUD20 GSH1 PHO81 CYT2 SRX1 20 GO:0016209 8.501877179137017E-6 antioxidant activity GO:0006979 2.803232277178101E-5 response to oxidative stress GO:0031970 3.649422775405556E-5 organelle envelope lumen GO:0016491 2.6492666720454873E-4 oxidoreductase activity GO:0055114 4.93934521729755E-4 oxidation-reduction process GO:0034599 6.325983477806764E-4 cellular response to oxidative stress GO:0044429 0.0010614617013589049 mitochondrial part GO:0003824 0.0018114578912630187 catalytic activity GO:0005758 0.003086294596661931 mitochondrial intermembrane space GO:0042221 0.005074016260252296 response to chemical stimulus GO:0045454 0.005184891990023525 cell redox homeostasis GO:0043167 0.006014348282996359 ion binding GO:0072593 0.006548894408145608 reactive oxygen species metabolic process GO:0006518 0.006548894408145608 peptide metabolic process GO:0051091 0.008064516129032091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0016661 0.00984952120383052 oxidoreductase activity, acting on other nitrogenous compounds as donors GO:0016721 0.00984952120383052 oxidoreductase activity, acting on superoxide radicals as acceptor GO:0016265 0.009934075633296917 death Set18a: MSN2 HAP4 ARG81 NRG1 SUT1 RAP1 ROX1 SOK2 PHD1 LEU3 YAP6 SWI6 SKO1 13 GO:0001071 1.6647071928824738E-12 nucleic acid binding transcription factor activity GO:0000988 1.1967496464892064E-7 protein binding transcription factor activity GO:0050789 3.5560641832021167E-7 regulation of biological process GO:0031323 5.093862397075174E-7 regulation of cellular metabolic process GO:0050794 8.541859998217127E-7 regulation of cellular process GO:0019222 9.387556734568057E-7 regulation of metabolic process GO:0080090 1.1174456154677209E-6 regulation of primary metabolic process GO:0065007 1.4042609355137798E-6 biological regulation GO:0032774 3.928721663617042E-6 RNA biosynthetic process GO:0051171 5.073757834059394E-6 regulation of nitrogen compound metabolic process GO:0009889 6.935515709067212E-6 regulation of biosynthetic process GO:0060255 1.2222491136380247E-5 regulation of macromolecule metabolic process GO:0031326 1.4078756459167061E-5 regulation of cellular biosynthetic process GO:0003676 1.6764907204323187E-5 nucleic acid binding GO:0048518 2.7429231919745863E-5 positive regulation of biological process GO:0019219 3.847218872466983E-5 regulation of nucleobase-containing compound metabolic process GO:0008134 4.073135376476444E-5 transcription factor binding GO:0001067 4.522207036795166E-5 regulatory region nucleic acid binding GO:0048522 6.737040852187941E-5 positive regulation of cellular process GO:0006351 1.1100753001509326E-4 transcription, DNA-dependent GO:0048519 1.1422454953947234E-4 negative regulation of biological process GO:0009893 1.241859441357698E-4 positive regulation of metabolic process GO:0009059 1.7596798974489674E-4 macromolecule biosynthetic process GO:0031325 1.7740919676928206E-4 positive regulation of cellular metabolic process GO:0048523 1.9832566075134175E-4 negative regulation of cellular process GO:0034645 2.4367457957073552E-4 cellular macromolecule biosynthetic process GO:0016070 2.619251688190462E-4 RNA metabolic process GO:0010468 3.2533696091083253E-4 regulation of gene expression GO:0051252 5.474829169435537E-4 regulation of RNA metabolic process GO:0010556 6.803038700018747E-4 regulation of macromolecule biosynthetic process GO:0006139 8.219424381726186E-4 nucleobase-containing compound metabolic process GO:0005634 8.443189073449892E-4 nucleus GO:0005488 0.0010547361386345645 binding GO:0003700 0.0012737374783156421 sequence-specific DNA binding transcription factor activity GO:0051173 0.0013018243022024703 positive regulation of nitrogen compound metabolic process GO:0009892 0.001476629073104277 negative regulation of metabolic process GO:0031324 0.0015930368906159112 negative regulation of cellular metabolic process GO:0010604 0.001593494383668184 positive regulation of macromolecule metabolic process GO:0009058 0.0016552003100635845 biosynthetic process GO:2000112 0.0017333120700137978 regulation of cellular macromolecule biosynthetic process GO:0003677 0.0018962332978384882 DNA binding GO:0044249 0.002099931765221337 cellular biosynthetic process GO:0006807 0.0025371360975015764 nitrogen compound metabolic process GO:0009891 0.002555133250567211 positive regulation of biosynthetic process GO:0051049 0.002567394094993388 regulation of transport GO:0031328 0.0030422424362690553 positive regulation of cellular biosynthetic process GO:0034641 0.003398219742433028 cellular nitrogen compound metabolic process GO:0045935 0.003918917762160268 positive regulation of nucleobase-containing compound metabolic process GO:0001078 0.0044208978416965805 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0016049 0.004639393481829346 cell growth GO:0051172 0.00543394748310948 negative regulation of nitrogen compound metabolic process GO:0043170 0.005596273891321141 macromolecule metabolic process GO:0005667 0.005628517823639318 transcription factor complex GO:0010467 0.0066173791596154646 gene expression GO:0044260 0.00669669250650479 cellular macromolecule metabolic process GO:0010605 0.007239891832856169 negative regulation of macromolecule metabolic process GO:0051716 0.007451899354378515 cellular response to stimulus GO:0010628 0.008263277728717922 positive regulation of gene expression GO:0009890 0.008433713149440329 negative regulation of biosynthetic process GO:0000975 0.008572881089982302 regulatory region DNA binding GO:0005515 0.009073633057125946 protein binding GO:0031327 0.009849600310552762 negative regulation of cellular biosynthetic process Set18b: YBL029W PET9 YBL029C-A 3 GO:0008219 0.008982035928142435 cell death Set19a: SWI4 SWI6 TEC1 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0000988 0.004331065137782144 protein binding transcription factor activity GO:0005667 0.005628517823639318 transcription factor complex GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set19b: SIM1 SRL1 CWP2 PCL2 YGR189C CWP1 MSB2 PET54 MNN5 UTR2 TOS2 YOR246C GIC2 GID8 GAT2 SWE1 YKL096C-B SVS1 PCL1 19 GO:0030312 1.6496212133637075E-6 external encapsulating structure GO:0005576 1.1476225083995643E-5 extracellular region GO:0000131 3.042714522740452E-5 incipient cellular bud site GO:0071944 5.8726787630490187E-5 cell periphery GO:0030427 1.3541950167680547E-4 site of polarized growth GO:0032878 4.406256884776601E-4 regulation of establishment or maintenance of cell polarity GO:0005933 6.391455601488623E-4 cellular bud GO:0007163 6.761880930475287E-4 establishment or maintenance of cell polarity GO:0031225 8.422995978368306E-4 anchored to membrane GO:0051726 0.0014229684696589063 regulation of cell cycle GO:0019899 0.0015582943759739228 enzyme binding GO:0000307 0.0015611931778422934 cyclin-dependent protein kinase holoenzyme complex GO:0070882 0.0032069296656661484 cellular cell wall organization or biogenesis GO:0071555 0.003497473345894279 cell wall organization GO:0045229 0.003868764588308948 external encapsulating structure organization GO:0071554 0.003877860530574516 cell wall organization or biogenesis GO:0006022 0.004271548436308276 aminoglycan metabolic process GO:0005199 0.004516711833784948 structural constituent of cell wall GO:0004693 0.004966746456458573 cyclin-dependent protein kinase activity GO:0051301 0.007399706240905801 cell division GO:0032268 0.00788933387374662 regulation of cellular protein metabolic process GO:0051246 0.009357652601972872 regulation of protein metabolic process Set20a: CBF1 MET32 MET4 3 GO:0006790 4.3143145070793245E-5 sulfur compound metabolic process GO:0000988 5.5072581225204377E-5 protein binding transcription factor activity GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0006520 0.0013294098984061088 cellular amino acid metabolic process GO:0006082 0.002754100520386723 organic acid metabolic process GO:0042180 0.0030598633630377486 cellular ketone metabolic process GO:0044106 0.004788670758258734 cellular amine metabolic process GO:0044272 0.005280528052805514 sulfur compound biosynthetic process GO:0009308 0.006880809314624022 amine metabolic process GO:0000096 0.0093838745524139 sulfur amino acid metabolic process Set20b: MET10 MET2 MET2-A LSB6 IES5 SUL2 USO1 MET6 GSH1 RAD59 10 GO:0044272 2.7100989984904758E-6 sulfur compound biosynthetic process GO:0006790 2.0087822055286845E-5 sulfur compound metabolic process GO:0016053 1.9546363390313392E-4 organic acid biosynthetic process GO:0044283 5.397751553505787E-4 small molecule biosynthetic process GO:0006520 0.0017969882824115714 cellular amino acid metabolic process GO:0044271 0.0019490044828478232 cellular nitrogen compound biosynthetic process GO:0044106 0.003441236088952942 cellular amine metabolic process GO:0006082 0.004523204602732419 organic acid metabolic process GO:0042180 0.005161445357459197 cellular ketone metabolic process GO:0009308 0.005482535210045088 amine metabolic process Set21a: GLN3 GAT1 2 GO:0019740 8.606996705876708E-5 nitrogen utilization GO:0006808 6.737031214911323E-4 regulation of nitrogen utilization GO:0009719 7.653409867431321E-4 response to endogenous stimulus GO:0090293 0.0013656538067599359 nitrogen catabolite regulation of transcription GO:0001079 0.0014170996693433336 nitrogen catabolite regulation of transcription from RNA polymerase II promoter GO:0090294 0.0017633574325516535 nitrogen catabolite activation of transcription GO:0042126 0.007511717145976385 nitrate metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set21b: CAN1 NPR2 DAN4 YJR151W-A AIM6 DCG1 DIP5 DAL5 DAL4 DAL7 CHA1 AVT1 DAL2 RRI2 GUD1 MCH4 DAL1 VAC17 18 GO:0043603 3.950110589133584E-7 cellular amide metabolic process GO:0000255 5.91174035219254E-7 allantoin metabolic process GO:0006725 6.640349319877897E-7 cellular aromatic compound metabolic process GO:0000256 1.384167340294693E-6 allantoin catabolic process GO:0009112 3.546801274692613E-6 nucleobase metabolic process GO:0043605 4.1525020208840845E-6 cellular amide catabolic process GO:0006144 8.536174972825695E-6 purine base metabolic process GO:0071705 4.3085500910209793E-5 nitrogen compound transport GO:0016810 3.872632932913269E-4 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0044437 6.644635686092732E-4 vacuolar part GO:0005773 7.815340298055473E-4 vacuole GO:0005774 0.0015015896986248624 vacuolar membrane GO:0055085 0.0016901495083380983 transmembrane transport GO:0071702 0.0017067568966351368 organic substance transport GO:0005215 0.0020535361830019663 transporter activity GO:0023051 0.006078299273897744 regulation of signaling GO:0008180 0.006079027355622685 signalosome GO:0009966 0.006802379157241481 regulation of signal transduction GO:0016020 0.006968927171206933 membrane GO:0009308 0.00813817149661063 amine metabolic process GO:0046483 0.009009222450684837 heterocycle metabolic process GO:0072521 0.009591297469073974 purine-containing compound metabolic process GO:0044425 0.009851991017881935 membrane part Set22a: ABF1 UME6 2 GO:0034389 0.008368200836818863 lipid particle organization Set22b: PUT3 YOR020W-A HSP10 POL31 GDS1 CAT8 YBR284W DHR2 MSC6 YKL190W FLC2 NUS1 ARO3 HUA1 LSM4 ACS1 ATP7 SSH1 RNP1 GPI12 YTA7 SWI4 YJR005C-A 23 GO:0005783 0.0037274598862876464 endoplasmic reticulum GO:0044432 0.007105446227081963 endoplasmic reticulum part GO:0042175 0.0071989748876364985 nuclear outer membrane-endoplasmic reticulum membrane network GO:0005789 0.00857714587383216 endoplasmic reticulum membrane Set23a: REB1 RPN4 2 Set23b: RPN2 REB1 EPL1 RPT1 PUP1 RPA14 SEC66 RET2 PET123 PRE9 PRE3 NPL4 RPN12 PRE4 BUD27 CPR1 OST1 17 GO:0000502 4.893938255895681E-9 proteasome complex GO:0032991 8.503735417448537E-8 macromolecular complex GO:0005839 8.820854397064314E-7 proteasome core complex GO:0044265 4.2150263999469575E-6 cellular macromolecule catabolic process GO:0009057 8.690167879217241E-6 macromolecule catabolic process GO:0031597 1.2297163818454766E-5 cytosolic proteasome complex GO:0042175 1.5184750027337847E-5 nuclear outer membrane-endoplasmic reticulum membrane network GO:0019774 1.674172193274816E-5 proteasome core complex, beta-subunit complex GO:0012505 2.366873003235371E-5 endomembrane system GO:0044257 3.3963712800788405E-5 cellular protein catabolic process GO:0030163 4.529527682092334E-5 protein catabolic process GO:0019538 1.1841108855856962E-4 protein metabolic process GO:0008233 1.274546012114666E-4 peptidase activity GO:0005838 3.332461121737356E-4 proteasome regulatory particle GO:0022624 3.332461121737356E-4 proteasome accessory complex GO:0006508 3.508795860111309E-4 proteolysis GO:0005789 3.917433806460602E-4 endoplasmic reticulum membrane GO:0044445 6.514876699542831E-4 cytosolic part GO:0044432 0.0010523353389109199 endoplasmic reticulum part GO:0008540 0.0016365303493843886 proteasome regulatory particle, base subcomplex GO:0043170 0.0024977883873963636 macromolecule metabolic process GO:0005783 0.002679372841119487 endoplasmic reticulum GO:0044260 0.003072721713739966 cellular macromolecule metabolic process GO:0044267 0.0031284567257160723 cellular protein metabolic process GO:0018193 0.003861265411190997 peptidyl-amino acid modification GO:0070003 0.007756545513982548 threonine-type peptidase activity GO:0045184 0.007952298730165114 establishment of protein localization GO:0043248 0.008692903429745562 proteasome assembly GO:0015031 0.00894147835371245 protein transport GO:0008144 0.00895522388059644 drug binding Set24a: HAP5 HAP3 HAP2 3 GO:0043467 3.880994593068554E-5 regulation of generation of precursor metabolites and energy GO:0045990 1.6255356878970366E-4 carbon catabolite regulation of transcription GO:0000429 2.2667341649728785E-4 carbon catabolite regulation of transcription from RNA polymerase II promoter GO:0005667 3.905502163342205E-4 transcription factor complex GO:0000436 4.315460135936882E-4 carbon catabolite activation of transcription from RNA polymerase II promoter GO:0006091 5.402929169237903E-4 generation of precursor metabolites and energy GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0007154 0.0011213935764833173 cell communication GO:0043457 0.0011853959222380302 regulation of cellular respiration GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0009605 0.002368573871612081 response to external stimulus GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0007584 0.0024928385559030257 response to nutrient GO:0055114 0.002863378616088628 oxidation-reduction process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0016602 0.004127966976264197 CCAAT-binding factor complex GO:0031668 0.00476068553871796 cellular response to extracellular stimulus GO:0031974 0.00513874920163652 membrane-enclosed lumen GO:0031670 0.005282179594106165 cellular response to nutrient GO:0051716 0.008384515738521489 cellular response to stimulus GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set24b: CCC1 SMF2-A COX6 COX4 PHO81 YHB1 GRX4 TYW1 ISA1 9 GO:0051540 1.4053476073320507E-4 metal cluster binding GO:0043167 6.506955162474056E-4 ion binding GO:0045277 7.398158005841283E-4 respiratory chain complex IV GO:0016491 8.7971985971935E-4 oxidoreductase activity GO:0055114 9.161752027763018E-4 oxidation-reduction process GO:0018130 0.0026243986369017757 heterocycle biosynthetic process GO:0070469 0.005191169597948426 respiratory chain GO:0044429 0.005479360529088836 mitochondrial part GO:0046483 0.005965177569133459 heterocycle metabolic process Set25a: ASH1 MCM1 SOK2 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0016049 0.0022220175034543205 cell growth GO:0040007 0.004529765547119604 growth GO:2000242 0.005376344086021723 negative regulation of reproductive process GO:0051093 0.005747126436781691 negative regulation of developmental process GO:0045596 0.006849315068493371 negative regulation of cell differentiation Set25b: POG1 YJL160C PCL1 YMR122W-A UTH1 HSP150 RPL15B SCW10 PKR1 FKS3 10 GO:0005576 1.418848254777298E-4 extracellular region GO:0030312 2.579137028392939E-4 external encapsulating structure GO:0071944 0.006686183737611366 cell periphery GO:0071841 0.0073288058408922906 cellular component organization or biogenesis at cellular level GO:0000148 0.007692307692307168 1,3-beta-D-glucan synthase complex Set26a: UME6 REB1 2 GO:0034389 0.004184100418409662 lipid particle organization GO:0051039 0.0095238095238093 positive regulation of transcription during meiosis Set26b: VPS30 GOS1 ECM29 TIF3 SUB1 YET2 HSC82 tK(UUU)P CLB2 MMS1 SPO16 GPI12 CAT8 APL4 MEI5 RTT107 CSR2 17 GO:0010529 4.272895598917574E-4 negative regulation of transposition GO:0010528 0.0020236863063564613 regulation of transposition GO:0016192 0.0021112721352449498 vesicle-mediated transport GO:0005515 0.005487092127784048 protein binding GO:0043170 0.005596273891321141 macromolecule metabolic process GO:0044260 0.00669669250650479 cellular macromolecule metabolic process GO:0032196 0.007149419067823651 transposition GO:0000151 0.007332862731141299 ubiquitin ligase complex Set27a: NRG1 SKN7 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set27b: USV1 YER010C IRC22 RMI1 NRG1 KNH1 NRG2 FMP48 CHS1 HEM13 GID8 GAT2 ISU2 AMN1 HER1 YER011W ADH3 HAP4 ICS2 MNN1 KTI12 ISF1 SKS1 GTO3-A 24 GO:0042710 0.0015015015015015039 biofilm formation GO:0000429 0.002105327059777428 carbon catabolite regulation of transcription from RNA polymerase II promoter GO:0045990 0.004954142370348944 carbon catabolite regulation of transcription GO:0031670 0.005282179594106165 cellular response to nutrient GO:0007584 0.00905008780077832 response to nutrient Set28a: ABF1 RPN4 2 Set28b: CDC39 MSH3 NUP49 NPR1 RPN8 PUP2 UBP6 ENO1 AIM46 KEM1 RAD50 YOR262W POL31 RPN10 NRD1 YJR005C-A SEM1 RAD23 18 GO:0044265 2.7507105472154377E-10 cellular macromolecule catabolic process GO:0009057 2.969074135713791E-9 macromolecule catabolic process GO:0000502 1.5139207574379614E-7 proteasome complex GO:0005838 5.510867188085284E-6 proteasome regulatory particle GO:0022624 5.510867188085284E-6 proteasome accessory complex GO:0009056 4.7930498947942075E-5 catabolic process GO:0006508 1.3891747748080382E-4 proteolysis GO:0032991 1.544862959393475E-4 macromolecular complex GO:0044248 2.4709098774416814E-4 cellular catabolic process GO:0008541 7.298824410228589E-4 proteasome regulatory particle, lid subcomplex GO:0044257 9.779430297345612E-4 cellular protein catabolic process GO:0030163 0.0011922000675285821 protein catabolic process GO:0044428 0.0012378325060481102 nuclear part GO:0032182 0.0016999575010624391 small conjugating protein binding GO:0003684 0.0021533473368405636 damaged DNA binding GO:0001069 0.004672897196261788 regulatory region RNA binding GO:0006308 0.005126452494874131 DNA catabolic process GO:0043234 0.00811213028891523 protein complex Set29a: CBF1 PHO4 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set29b: RPS4A LSB5 GTR1 PFK27 MNN1 STB3-A GRX1 HMS2 SPL2 PHO86 PHO84 ARO9 STB3 IRC22 14 GO:0006820 0.0028708133971291775 anion transport GO:0016740 0.005041765990902359 transferase activity Set30a: MSN2 SPT2 RLM1 PHD1 STE12 SWI4 STB1 SWI6 DAL82 NDD1 10 GO:0048518 3.719210767204403E-8 positive regulation of biological process GO:0048522 1.0943266176114874E-7 positive regulation of cellular process GO:0009893 2.2841467205865825E-7 positive regulation of metabolic process GO:0031325 3.527410231755075E-7 positive regulation of cellular metabolic process GO:0051173 4.15328252397272E-6 positive regulation of nitrogen compound metabolic process GO:0010604 5.397314588795437E-6 positive regulation of macromolecule metabolic process GO:0050789 1.126203810012421E-5 regulation of biological process GO:0031323 1.4982180793828759E-5 regulation of cellular metabolic process GO:0045935 1.7048058510849235E-5 positive regulation of nucleobase-containing compound metabolic process GO:0050794 2.2112732845195536E-5 regulation of cellular process GO:0019222 2.388473473477796E-5 regulation of metabolic process GO:0080090 2.7393325676311653E-5 regulation of primary metabolic process GO:0065007 3.225638310671508E-5 biological regulation GO:0032774 7.260999285443618E-5 RNA biosynthetic process GO:0051171 8.813883949782464E-5 regulation of nitrogen compound metabolic process GO:0009889 1.1192210055436556E-4 regulation of biosynthetic process GO:0009891 1.6784165113223226E-4 positive regulation of biosynthetic process GO:0060255 1.7229049089800277E-4 regulation of macromolecule metabolic process GO:0031326 1.9266206380758657E-4 regulation of cellular biosynthetic process GO:0031328 2.0353226218910038E-4 positive regulation of cellular biosynthetic process GO:0005667 3.905502163342205E-4 transcription factor complex GO:0019219 4.1694304965809125E-4 regulation of nucleobase-containing compound metabolic process GO:0010628 6.212059296121048E-4 positive regulation of gene expression GO:0001071 9.043645765923846E-4 nucleic acid binding transcription factor activity GO:0006351 9.416149694579763E-4 transcription, DNA-dependent GO:0033309 0.0010319917440660491 SBF transcription complex GO:0009059 0.0013204001782709037 macromolecule biosynthetic process GO:0010557 0.0015723393738243704 positive regulation of macromolecule biosynthetic process GO:0034645 0.0016954797124965285 cellular macromolecule biosynthetic process GO:0016070 0.0018005591256497503 RNA metabolic process GO:0010468 0.0021425940047737 regulation of gene expression GO:0051252 0.003204079889989184 regulation of RNA metabolic process GO:0010556 0.0037698467058857707 regulation of macromolecule biosynthetic process GO:0006139 0.004294990157237373 nucleobase-containing compound metabolic process GO:0051254 0.004304199772639466 positive regulation of RNA metabolic process GO:0005634 0.004386343639349827 nucleus GO:0005488 0.005177764632024365 binding GO:0000988 0.005450008837262928 protein binding transcription factor activity GO:0000083 0.007121809248582008 regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0009058 0.00733923909612196 biosynthetic process GO:0071310 0.007522650583757998 cellular response to organic substance GO:2000112 0.007718057742026978 regulation of cellular macromolecule biosynthetic process GO:0044249 0.008813275790916654 cellular biosynthetic process Set30b: YDR524W-A YKL096C-B SNA2 AGE1 AGE1-B 5 Set31a: SKN7 SWI6 AFT2 NDD1 4 GO:0048518 0.006217160724096565 positive regulation of biological process GO:0000988 0.008447845205531702 protein binding transcription factor activity GO:0048522 0.008831828472544836 positive regulation of cellular process Set31b: TSL1 CUE4 SLM4 TSL1-A ECM33 5 GO:0005946 0.006024096385541824 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) GO:0034448 0.006249999999999303 EGO complex Set32a: MAC1 GCR2 DIG1 SWI5 YML081W SPT2 RLM1 7 GO:0050789 3.5055379734817737E-4 regulation of biological process GO:0031323 4.307304007614707E-4 regulation of cellular metabolic process GO:0050794 5.624123299697319E-4 regulation of cellular process GO:0019222 5.954200545511292E-4 regulation of metabolic process GO:0080090 6.567367848695359E-4 regulation of primary metabolic process GO:0065007 7.301058499006774E-4 biological regulation GO:0032774 0.0013061843385543882 RNA biosynthetic process GO:0051171 0.0014929739897344366 regulation of nitrogen compound metabolic process GO:0009889 0.0017628397040291878 regulation of biosynthetic process GO:0060255 0.0023769385322563942 regulation of macromolecule metabolic process GO:0031326 0.00257560631144518 regulation of cellular biosynthetic process GO:0019219 0.004417604191566779 regulation of nucleobase-containing compound metabolic process GO:0006351 0.007810657506841606 transcription, DNA-dependent GO:0009059 0.009786451754017909 macromolecule biosynthetic process Set32b: snR190 snR128 RPA34 3 GO:0044452 0.0030093521404980367 nucleolar part GO:0005730 0.004408256404937475 nucleolus GO:0031974 0.00513874920163652 membrane-enclosed lumen Set33a: GLN3 PHO2 2 GO:0042126 0.007511717145976385 nitrate metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set33b: DPS1 tT(AGU)H MCH4 SPO73 LAP4 HIS4 HSL1 GPA1-A YHB1 ACA1 BPT1 STP2 RRI2 PHO81 14 GO:0008180 0.00303951367781151 signalosome Set34a: MOT3 ROX1 2 Set34b: YPR148C HAP4 SED1 NCE103 NCE102 GAC1 IDH1 PEA2 YER150W KTI12 YAP6 PRB1 12 GO:0030312 0.00757051921581292 external encapsulating structure GO:0071704 0.009535160905843247 organic substance metabolic process Set35a: ABF1 REB1 2 Set35b: BET3 TAF5 RPT5 NAS6 MET5 PHB2 ATP18 SLA2 REG1 CAT8 SUI1 MET1 GPI12 KTR4 RPO31 YML081W RPC19 YNL115C IML1 19 GO:0009304 0.0027207860103666028 tRNA transcription GO:0055029 0.002721277405681132 nuclear DNA-directed RNA polymerase complex GO:0030880 0.004497806587496602 RNA polymerase complex GO:0005666 0.0053798288825513095 DNA-directed RNA polymerase III complex Set36a: HAP4 HAP2 2 GO:0043467 0.0012535612535609821 regulation of generation of precursor metabolites and energy GO:0045990 0.0032510713757940256 carbon catabolite regulation of transcription GO:0000429 0.004136789851075142 carbon catabolite regulation of transcription from RNA polymerase II promoter GO:0005667 0.005628517823639318 transcription factor complex GO:0000436 0.00654511453950429 carbon catabolite activation of transcription from RNA polymerase II promoter GO:0006091 0.0067283352310704946 generation of precursor metabolites and energy GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set36b: COX9 ATP3 SMF2-A ATP1 COX6 COX7 COX4 INH1 RIP1 IDP1 QCR7 ATP19 ATP17 YEL025C 14 GO:0006818 6.417606293127919E-12 hydrogen transport GO:0019866 9.199426359679701E-12 organelle inner membrane GO:0034654 3.4264475857426454E-10 nucleobase-containing compound biosynthetic process GO:0044455 6.336230953687791E-10 mitochondrial membrane part GO:0018130 9.019978564243468E-10 heterocycle biosynthetic process GO:0005215 1.8498255548758048E-9 transporter activity GO:0044271 4.324989452332733E-9 cellular nitrogen compound biosynthetic process GO:0031975 4.342422492312771E-9 envelope GO:0044429 5.204430971494868E-9 mitochondrial part GO:0055085 5.7333123658617196E-9 transmembrane transport GO:0031967 6.255373191815575E-8 organelle envelope GO:0009142 8.551178279063059E-8 nucleoside triphosphate biosynthetic process GO:0046483 1.171284396574374E-7 heterocycle metabolic process GO:0009145 1.4845570980804817E-7 purine nucleoside triphosphate biosynthetic process GO:0005739 1.5313784695911534E-7 mitochondrion GO:0009201 1.6324468871312377E-7 ribonucleoside triphosphate biosynthetic process GO:0009206 1.7966999314318086E-7 purine ribonucleoside triphosphate biosynthetic process GO:0045277 2.0378687615502894E-7 respiratory chain complex IV GO:0006811 2.4223394466591923E-7 ion transport GO:0072522 6.922941200397954E-7 purine-containing compound biosynthetic process GO:0070469 7.880385165532503E-7 respiratory chain GO:0072521 8.786297372464111E-7 purine-containing compound metabolic process GO:0045259 1.2415359550231788E-6 proton-transporting ATP synthase complex GO:0055086 1.2676163779014776E-6 nucleobase-containing small molecule metabolic process GO:0009260 3.666019851991525E-6 ribonucleotide biosynthetic process GO:0009152 3.8866157043570265E-6 purine ribonucleotide biosynthetic process GO:0015985 4.259814549005653E-6 energy coupled proton transport, down electrochemical gradient GO:0006164 6.468809898587286E-6 purine nucleotide biosynthetic process GO:0044281 6.605613507181176E-6 small molecule metabolic process GO:0006754 8.150222149318216E-6 ATP biosynthetic process GO:0016469 1.0513088027749987E-5 proton-transporting two-sector ATPase complex GO:0006091 1.0960499390683232E-5 generation of precursor metabolites and energy GO:0009165 1.4236779507365549E-5 nucleotide biosynthetic process GO:0031966 1.6762250182064647E-5 mitochondrial membrane GO:0006119 2.1020365164005793E-5 oxidative phosphorylation GO:0031090 2.5055412912406168E-5 organelle membrane GO:0044425 2.5390675626475636E-5 membrane part GO:0051234 3.34765423751856E-5 establishment of localization GO:0022900 4.3045378206467594E-5 electron transport chain GO:0051179 6.468867093198734E-5 localization GO:0015077 1.4530659691949912E-4 monovalent inorganic cation transmembrane transporter activity GO:0016020 1.491330589563294E-4 membrane GO:0045261 1.606243757786566E-4 proton-transporting ATP synthase complex, catalytic core F(1) GO:0034220 1.7522892681968603E-4 ion transmembrane transport GO:0016675 2.3290400413989132E-4 oxidoreductase activity, acting on a heme group of donors GO:0015002 2.3290400413989132E-4 heme-copper terminal oxidase activity GO:0055114 4.426849826593344E-4 oxidation-reduction process GO:0033178 4.885631801020929E-4 proton-transporting two-sector ATPase complex, catalytic domain GO:0015980 5.355177377021318E-4 energy derivation by oxidation of organic compounds GO:0045275 8.253968131539019E-4 respiratory chain complex III GO:0022904 8.624962185333621E-4 respiratory electron transport chain GO:0016491 8.690747113088509E-4 oxidoreductase activity GO:0032991 9.108846750807412E-4 macromolecular complex GO:0015672 0.001025814315540495 monovalent inorganic cation transport GO:0009295 0.0011849511207661768 nucleoid GO:0003824 0.0014661210575827933 catalytic activity GO:0045263 0.0015706051318177476 proton-transporting ATP synthase complex, coupling factor F(o) GO:0015075 0.0022618702792375905 ion transmembrane transporter activity GO:0006793 0.0027372900650870914 phosphorus metabolic process GO:0005746 0.003188497394095558 mitochondrial respiratory chain GO:0044422 0.0035333427712599856 organelle part GO:0006807 0.004035022216601788 nitrogen compound metabolic process GO:0033177 0.004702063293467807 proton-transporting two-sector ATPase complex, proton-transporting domain GO:0044444 0.005263584636844533 cytoplasmic part GO:0034641 0.005283898540683677 cellular nitrogen compound metabolic process GO:0015078 0.005949656750572096 hydrogen ion transmembrane transporter activity Set37a: MBP1 SWI6 REB1 3 GO:0000083 6.138335448029981E-4 regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0031974 0.00513874920163652 membrane-enclosed lumen GO:0005667 0.005628517823639318 transcription factor complex GO:0000082 0.00630252100840354 G1/S transition of mitotic cell cycle Set37b: ELO1 RUF1 TIM23 RNR1 ACC1 CDC6 HLR1 7 GO:0071897 0.005533928707731427 DNA biosynthetic process GO:0006260 0.005533928707731427 DNA replication GO:0005971 0.006024096385541824 ribonucleoside-diphosphate reductase complex GO:0006633 0.007645259938838016 fatty acid biosynthetic process Set38a: YAP6 MOT3 GCR2 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0000988 0.004331065137782144 protein binding transcription factor activity GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set38b: snR55 snR57 SED1 snR40 snR61 CAF40 6 GO:0043414 3.8053762819811994E-6 macromolecule methylation GO:0006730 1.0315881469141673E-5 one-carbon metabolic process GO:0009451 7.671070154687985E-5 RNA modification GO:0000496 1.2287106069431357E-4 base pairing GO:0030529 1.494931996114889E-4 ribonucleoprotein complex GO:0031974 7.716980792315753E-4 membrane-enclosed lumen GO:0032991 9.28790464896329E-4 macromolecular complex GO:0044428 9.300580311158607E-4 nuclear part GO:0044452 0.001817875640765801 nucleolar part GO:0005732 0.00238133790167526 small nucleolar ribonucleoprotein complex GO:0000154 0.0024469162581004416 rRNA modification GO:0019843 0.003967554223241011 rRNA binding GO:0070013 0.006501455973903447 intracellular organelle lumen GO:0043233 0.006501455973903447 organelle lumen GO:0000498 0.006968168491709258 base pairing with RNA GO:0005730 0.008037836723568132 nucleolus GO:0030015 0.008097165991902366 CCR4-NOT core complex GO:0006396 0.008396438667839432 RNA processing GO:0000944 0.00916138125440458 base pairing with rRNA GO:0043228 0.009829488828070177 non-membrane-bounded organelle GO:0043232 0.009829488828070177 intracellular non-membrane-bounded organelle Set39a: NRG1 PHO2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set39b: ERG4 FMP48 SED1 GTR1 IDH2 MNN1 DGK1 YEF3 YKL096C-B PHO84 IRC22 HMG1 PDR1 13 GO:2001038 0.0057803468208086255 regulation of cellular response to drug GO:0016020 0.006968927171206933 membrane GO:2001040 0.0073529411764705266 positive regulation of cellular response to drug GO:0048584 0.008982035928142914 positive regulation of response to stimulus GO:0035690 0.009345794392523593 cellular response to drug GO:0044425 0.009851991017881935 membrane part Set40a: ABF1 PHO2 2 GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set40b: GPR1 TAF4 TID3 FBA1 IDH1 NOB1 PAM16 GZF3 NCE103 SGT1 GCN2 PAN6 12 GO:0051606 2.733360666940041E-4 detection of stimulus GO:0009593 3.633720930232545E-4 detection of chemical stimulus GO:0044283 0.006284691640850991 small molecule biosynthetic process Set41a: REB1 SUM1 2 Set41b: FZO1 MAM1 KAP104 GYP6 YKR015C SRL2 NUP157 FCJ1 DTR1 YJL043W 10 GO:0032592 0.00489795918367349 integral to mitochondrial membrane Set42a: MBP1 PHO2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set42b: ERP3 TOS3 MPT5 LAP4 THI22 HSL1 YPR120C HST2 YPL014W ATG19 tC(GCA)P2 SEN1 GIN4 CDC7 14 GO:0031935 2.1131963942661445E-4 regulation of chromatin silencing GO:0019538 3.807861493103345E-4 protein metabolic process GO:0051302 6.205046477232511E-4 regulation of cell division GO:0060968 7.821044791883481E-4 regulation of gene silencing GO:0040029 0.001924778761061952 regulation of gene expression, epigenetic GO:0006793 0.0027372900650870914 phosphorus metabolic process GO:0051726 0.003436846441920797 regulation of cell cycle GO:0071775 0.004354136429608109 regulation of cell cycle cytokinesis GO:0032465 0.004761904761904784 regulation of cytokinesis GO:0044267 0.005212117652045384 cellular protein metabolic process GO:0016458 0.005663066675632961 gene silencing GO:0034045 0.007739938080497584 pre-autophagosomal structure membrane GO:0046777 0.00784313725490184 protein autophosphorylation Set43a: GLN3 DAL82 HAP2 3 GO:0019740 2.568376607803346E-4 nitrogen utilization GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0007154 0.0011213935764833173 cell communication GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0006808 0.0019914960404520234 regulation of nitrogen utilization GO:0009719 0.0022618813548728046 response to endogenous stimulus GO:0009605 0.002368573871612081 response to external stimulus GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0007584 0.0024928385559030257 response to nutrient GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0090293 0.004015429849727145 nitrogen catabolite regulation of transcription GO:0001079 0.004172571248622252 nitrogen catabolite regulation of transcription from RNA polymerase II promoter GO:0031668 0.00476068553871796 cellular response to extracellular stimulus GO:0090294 0.005189309015794733 nitrogen catabolite activation of transcription GO:0031670 0.005282179594106165 cellular response to nutrient GO:0051716 0.008384515738521489 cellular response to stimulus GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set43b: GLT1 DCG1 UGA3 ASN1 NOC4 DAL2 6 GO:0030692 0.003490401396160753 Noc4p-Nop14p complex GO:0030689 0.00607902735562302 Noc complex Set44a: NRG1 HAP1 SKO1 NDD1 4 GO:0000988 2.0017516225474654E-6 protein binding transcription factor activity GO:0001071 0.0025913081073285975 nucleic acid binding transcription factor activity GO:0005515 0.005314620789852395 protein binding GO:0048518 0.006217160724096565 positive regulation of biological process GO:0001191 0.006734006734006697 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription GO:0008134 0.007151014361113119 transcription factor binding GO:0048522 0.008831828472544836 positive regulation of cellular process Set44b: COT1-A YKL096C-B FAA1 COT1 4 GO:0035383 0.0012515644555694885 thioester metabolic process Set45a: CBF1 SKN7 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set45b: snR47 GSH1 RPI1 YDR042C MET4 OLE1 RHO3 MNN1 LSB6 SDS23 PHO91 MET28 LEU4 NCA3 IRC22 YNR014W FMP48 YAP5 YJL115W 19 GO:0044272 2.951911398524341E-4 sulfur compound biosynthetic process GO:0006790 0.001093405765876675 sulfur compound metabolic process GO:0016053 0.0018974150793997513 organic acid biosynthetic process GO:0010035 0.002772500457791604 response to inorganic substance GO:0044283 0.0028155312825402625 small molecule biosynthetic process GO:0010638 0.009504674282795245 positive regulation of organelle organization Set46a: UME6 SUT1 2 GO:0034389 0.004184100418409662 lipid particle organization GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set46b: YGR067C GAC1 ACS1 YOR152C FLC2 YIG1 YKR009C CSM4 PDR5 tL(CAA)K 10 GO:0046677 0.007751937984496201 response to antibiotic GO:0042908 0.008163265306122875 xenobiotic transport GO:0034397 0.009803921568626871 telomere localization Set47a: MET32 MET31 2 GO:0042762 6.733855581244427E-5 regulation of sulfur metabolic process GO:0033238 2.5131942699168117E-4 regulation of cellular amine metabolic process GO:0006521 2.5875452820422036E-4 regulation of cellular amino acid metabolic process GO:0010565 8.189276514643707E-4 regulation of cellular ketone metabolic process GO:0006790 0.001273521726720097 sulfur compound metabolic process GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0001010 0.008566533409480154 sequence-specific DNA binding transcription factor recruiting transcription factor activity Set47b: MET2 MET2-A MET16 MET5 IES5 NUT2 USO1 CYS3 MET14 MET6 SAM1 YLR179C RAD59 IML1 14 GO:0044272 8.219191750984406E-10 sulfur compound biosynthetic process GO:0006790 1.3314126474464733E-9 sulfur compound metabolic process GO:0016053 2.007174286010666E-6 organic acid biosynthetic process GO:0006520 4.98400731239444E-6 cellular amino acid metabolic process GO:0000096 9.57747639671875E-6 sulfur amino acid metabolic process GO:0044283 1.2141154502284926E-5 small molecule biosynthetic process GO:0006082 2.675268896791837E-5 organic acid metabolic process GO:0044271 3.3771432380716415E-5 cellular nitrogen compound biosynthetic process GO:0042180 3.401284275036045E-5 cellular ketone metabolic process GO:0044106 9.019765450466848E-5 cellular amine metabolic process GO:0009308 2.048092829796542E-4 amine metabolic process GO:0009066 6.78076268014006E-4 aspartate family amino acid metabolic process GO:0009309 7.016599046098578E-4 amine biosynthetic process GO:0000097 0.001042897780346973 sulfur amino acid biosynthetic process GO:0009069 0.002069663920698227 serine family amino acid metabolic process GO:0009070 0.008795826717434263 serine family amino acid biosynthetic process GO:0008652 0.008986651207434023 cellular amino acid biosynthetic process Set48a: SKN7 XBP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set48b: YKL063C YNL234W MSN4 TCB2 SUR7 YML053C GIC2 MGA1 NDE1 SCW10 FKS3 11 GO:0032502 3.1185929004833837E-4 developmental process GO:0022604 0.0035014366271389637 regulation of cell morphogenesis GO:0048869 0.0037662855172930047 cellular developmental process GO:0008360 0.003830439223697516 regulation of cell shape GO:0007569 0.00676437377084625 cell aging GO:0000148 0.007692307692307168 1,3-beta-D-glucan synthase complex Set49a: RAP1 MSN4 FKH2 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0016458 0.0025536140506196873 gene silencing Set49b: RPS1B IRC15 SWI1 ECM19-A TEM1 5 Set50a: YAP7 UME6 2 GO:0034389 0.004184100418409662 lipid particle organization GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set50b: PST1 ECM38 YLR297W YHC1 CDC34 UBC5 ATP14 MAK21 8 GO:0006805 0.006257822277842747 xenobiotic metabolic process GO:0030690 0.006968641114981779 Noc1p-Noc2p complex Set51a: GCN4 LEU3 2 GO:2000282 0.007246376811594155 regulation of cellular amino acid biosynthetic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set51b: MET4 ILV5 ATG33 ILV3 LEU4 BAP2 LEU1 AQR1 8 GO:0006520 1.5240729308457348E-5 cellular amino acid metabolic process GO:0016053 2.2296232004167117E-5 organic acid biosynthetic process GO:0044271 6.222362406620232E-5 cellular nitrogen compound biosynthetic process GO:0044283 8.044725873014713E-5 small molecule biosynthetic process GO:0044106 1.297441050635478E-4 cellular amine metabolic process GO:0009308 2.3900731787563083E-4 amine metabolic process GO:0006082 2.7694964957330207E-4 organic acid metabolic process GO:0042180 3.2902500662002624E-4 cellular ketone metabolic process GO:0009082 4.8896719262978E-4 branched chain family amino acid biosynthetic process GO:0009081 7.239356047621722E-4 branched chain family amino acid metabolic process GO:0051540 0.0023782568521108654 metal cluster binding GO:0009316 0.0032894736842101926 3-isopropylmalate dehydratase complex GO:0009309 0.0059659753059514275 amine biosynthetic process Set52a: PHD1 HAP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set52b: YER048C ERG5 CWP2 UTR4 CYC7 ERG11 tQ(UUG)E1 YKL096C-B ERG11-A 9 GO:0046906 8.551994573124628E-5 tetrapyrrole binding GO:0009055 1.0179224263364538E-4 electron carrier activity GO:0004497 0.0016415868673050876 monooxygenase activity GO:0044107 0.003528147365139056 cellular alcohol metabolic process GO:0005506 0.005483549351944273 iron ion binding GO:0044108 0.005819889507433426 cellular alcohol biosynthetic process GO:0032451 0.006521739130433288 demethylase activity GO:0016705 0.009849521203830537 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Set53a: MSN2 YAP6 SKN7 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity Set53b: YPR148C ICS2 NCE102 MDH2 MGA1 AMN1 TRM13 YBR085C-A 8 Set54a: SWI4 STB1 SWI6 FKH2 4 GO:0005667 2.5609850251418857E-5 transcription factor complex GO:0048518 2.0104118072084663E-4 positive regulation of biological process GO:0000988 2.1428507003319077E-4 protein binding transcription factor activity GO:0048522 3.2655912895425713E-4 positive regulation of cellular process GO:0009893 4.5765085988733206E-4 positive regulation of metabolic process GO:0031325 5.56609914430763E-4 positive regulation of cellular metabolic process GO:0000083 6.138335448029981E-4 regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0031974 8.792363438971205E-4 membrane-enclosed lumen GO:0051173 0.0017103808914118003 positive regulation of nitrogen compound metabolic process GO:0010604 0.0019142550561718134 positive regulation of macromolecule metabolic process GO:0045935 0.003247105670396677 positive regulation of nucleobase-containing compound metabolic process GO:0044428 0.0037885414713808895 nuclear part GO:0033309 0.004127966976264183 SBF transcription complex GO:0022402 0.006129717506961671 cell cycle process GO:0044427 0.007815808879834709 chromosomal part GO:0044451 0.008491731087552695 nucleoplasm part GO:0032991 0.009594114428454424 macromolecular complex Set54b: GIC1 SRL1 YOR246C NUD1 NDD1 5 GO:0009986 0.004612546125456227 cell surface GO:0044430 0.008793881703582153 cytoskeletal part Set55a: YOX1 MCM1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set55b: MCM5 UTH1 HST4 PIG1 DBF2 RVB1 MCM3 KIN3 8 GO:0016458 4.223638947522158E-5 gene silencing GO:0040029 0.0010209810985636074 regulation of gene expression, epigenetic GO:0036094 0.001100986747161587 small molecule binding GO:0004386 0.0012309390946256416 helicase activity GO:0031298 0.0017411156144113368 replication fork protection complex GO:0051172 0.0017721950748313953 negative regulation of nitrogen compound metabolic process GO:0000808 0.0025399192230157893 origin recognition complex GO:0045934 0.0033144116082175043 negative regulation of nucleobase-containing compound metabolic process GO:0065007 0.004031171623208747 biological regulation GO:0009889 0.004395450539561947 regulation of biosynthetic process GO:0003688 0.004691898654988847 DNA replication origin binding GO:0000811 0.004799543853272302 GINS complex GO:0071162 0.004799543853272302 CMG complex GO:0048519 0.005660742258387816 negative regulation of biological process GO:0031261 0.005844535359438963 DNA replication preinitiation complex GO:0051320 0.005891016200294405 S phase GO:0010629 0.006050161872171892 negative regulation of gene expression GO:0031326 0.0060816078543365 regulation of cellular biosynthetic process GO:0009890 0.006545998812506818 negative regulation of biosynthetic process GO:0003682 0.006670250913446025 chromatin binding GO:0009892 0.007148109948351064 negative regulation of metabolic process GO:0031327 0.007349433326672847 negative regulation of cellular biosynthetic process GO:0031324 0.007535436357515149 negative regulation of cellular metabolic process GO:0048523 0.007748619429143219 negative regulation of cellular process GO:0032993 0.00830018522813935 protein-DNA complex GO:0005656 0.008766803039158454 pre-replicative complex GO:0003824 0.009278048887047531 catalytic activity Set56a: GCN4 BAS1 2 GO:2000144 0.008130081300812846 positive regulation of transcription initiation, DNA-dependent Set56b: MRPS17 GCV3 MET6 ADE3 STR3 IES5 TPN1 SHM2 HIS4 GCV2 10 GO:0006520 1.2172098539978974E-6 cellular amino acid metabolic process GO:0044106 3.380281516477647E-6 cellular amine metabolic process GO:0006730 3.836639190647936E-6 one-carbon metabolic process GO:0006082 6.731586030592286E-6 organic acid metabolic process GO:0009308 8.028932489872389E-6 amine metabolic process GO:0042180 8.601240413029765E-6 cellular ketone metabolic process GO:0005960 8.161036100769426E-5 glycine cleavage complex GO:0048037 5.877297662392433E-4 cofactor binding GO:0044272 6.773946148625498E-4 sulfur compound biosynthetic process GO:0006547 0.0012406947890817837 histidine metabolic process GO:0019842 0.0015854683253104399 vitamin binding GO:0006790 0.0021346037275493212 sulfur compound metabolic process GO:0051180 0.004081632653061661 vitamin transport GO:0044281 0.005340585198701559 small molecule metabolic process GO:0016810 0.005712133576046458 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016741 0.008152173913043168 transferase activity, transferring one-carbon groups GO:0016053 0.009346369191201019 organic acid biosynthetic process GO:0016638 0.009538250716369838 oxidoreductase activity, acting on the CH-NH2 group of donors Set57a: ARG81 ARG80 GCN4 3 GO:0006520 0.0013294098984061088 cellular amino acid metabolic process GO:0006082 0.002754100520386723 organic acid metabolic process GO:0042180 0.0030598633630377486 cellular ketone metabolic process GO:0000988 0.004331065137782144 protein binding transcription factor activity GO:0044106 0.004788670758258734 cellular amine metabolic process GO:0009308 0.006880809314624022 amine metabolic process Set57b: TAF13 ARG81 ARG3 ARG8 ARG5,6 5 GO:0006591 3.908540160250286E-5 ornithine metabolic process GO:0006520 6.546079100534973E-4 cellular amino acid metabolic process GO:0006082 0.0016923679672936351 organic acid metabolic process GO:0042180 0.0019398317902338115 cellular ketone metabolic process GO:0006592 0.002262443438914034 ornithine biosynthetic process GO:0009064 0.0028183870914575944 glutamine family amino acid metabolic process GO:0044106 0.003441236088952942 cellular amine metabolic process GO:0009308 0.005482535210045088 amine metabolic process GO:0009348 0.006024096385541824 ornithine carbamoyltransferase complex GO:0045920 0.008130081300812846 negative regulation of exocytosis GO:0051051 0.00867052023121341 negative regulation of transport Set58a: PHD1 NDD1 FKH2 3 GO:0000117 3.077740818216149E-4 regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0090282 0.002134097786271703 positive regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0016049 0.0022220175034543205 cell growth GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0000988 0.004331065137782144 protein binding transcription factor activity GO:0040007 0.004529765547119604 growth GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set58b: ICS2 OCA5 WSC4 AMN1 YHP1 PPN1 6 Set59a: NRG1 UME6 2 GO:0016049 7.537372806834754E-4 cell growth GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0040007 0.0015492594070577977 growth GO:0034389 0.004184100418409662 lipid particle organization GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051039 0.0095238095238093 positive regulation of transcription during meiosis Set59b: IME2 MES1 SMT3 YOR338W YJL107C GNP1 YGR266W 7 GO:0017102 0.006024096385541824 methionyl glutamyl tRNA synthetase complex Set60a: PHO2 SUM1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set60b: SAS5 YDR042C YAR1 ORC3 SPO75 HSP82 PHM6 7 GO:0032846 0.0053475935828875614 positive regulation of homeostatic process GO:0032844 0.007556675062972608 regulation of homeostatic process GO:0016458 0.008197996681060159 gene silencing GO:0071841 0.009163887707795353 cellular component organization or biogenesis at cellular level Set61a: PHO2 REB1 2 GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set61b: GCS1 PRP22 SPT20 SHS1 TCO89 ISD11 YPT6 7 GO:0023052 4.3335100433717445E-4 signaling GO:0007165 9.463544167913375E-4 signal transduction GO:0019898 0.0023887523887520046 extrinsic to membrane GO:0007154 0.003113091248817627 cell communication GO:0031312 0.00410386421874537 extrinsic to organelle membrane GO:0005793 0.007918552036202326 endoplasmic reticulum-Golgi intermediate compartment GO:0000386 0.008547008547007923 second spliceosomal transesterification activity GO:0044093 0.009946477562802215 positive regulation of molecular function Set62a: GCR1 GCR2 2 GO:0072361 9.192866335722522E-5 regulation of glycolysis by regulation of transcription from RNA polymerase II promoter GO:0072363 2.3889154323936682E-4 regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter GO:0043471 3.5795251163344343E-4 regulation of cellular carbohydrate catabolic process GO:0060963 7.166746297181001E-4 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0060962 9.447331128955547E-4 regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0010675 0.0010318755745669101 regulation of cellular carbohydrate metabolic process GO:0043467 0.0012535612535609821 regulation of generation of precursor metabolites and energy GO:0006109 0.0014110496038207362 regulation of carbohydrate metabolic process GO:0005635 0.004038228563736585 nuclear envelope GO:0031329 0.004379054680260413 regulation of cellular catabolic process GO:0009894 0.004749599092979486 regulation of catabolic process GO:0006091 0.0067283352310704946 generation of precursor metabolites and energy GO:0012505 0.006976316300557754 endomembrane system GO:0031975 0.007768498737617779 envelope GO:0044262 0.007859271080281276 cellular carbohydrate metabolic process GO:0043470 0.008474576271186491 regulation of carbohydrate catabolic process Set62b: PDC1 CDC19 CYC3 GPM1 BMH1 SBP1 TDH3 7 GO:0006091 6.135619727267807E-5 generation of precursor metabolites and energy GO:0044262 9.029179849599607E-5 cellular carbohydrate metabolic process GO:0044282 1.383704193415177E-4 small molecule catabolic process GO:0005975 2.160201567817304E-4 carbohydrate metabolic process GO:0016052 4.93861148745834E-4 carbohydrate catabolic process GO:0051248 0.001734731362239017 negative regulation of protein metabolic process GO:0032269 0.0018267161780595167 negative regulation of cellular protein metabolic process GO:0006066 0.002049519425399884 alcohol metabolic process GO:0034637 0.002220441584224353 cellular carbohydrate biosynthetic process GO:0016051 0.002787689145332132 carbohydrate biosynthetic process GO:0000267 0.004816569300821541 cell fraction GO:0051219 0.005494505494505476 phosphoprotein binding GO:0042430 0.005725190839695783 indole-containing compound metabolic process GO:0046164 0.0065560992194355575 alcohol catabolic process GO:0051439 0.008196721311475488 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0000287 0.008714521906862517 magnesium ion binding GO:0006090 0.009230769230769244 pyruvate metabolic process GO:0019439 0.009433962264150551 aromatic compound catabolic process Set63a: YAP6 SPT23 PHO2 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set63b: GPI14 RPS14B SOP4 YJR011C 4 Set64a: YAP7 GCN4 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set64b: URA2 GLT1 ARG1 UGA3 LAP4 HSL1 TRP2 BAP2 PTC2 YHI9 10 GO:0044106 1.297441050635478E-4 cellular amine metabolic process GO:0009308 2.3900731787563083E-4 amine metabolic process GO:0006520 6.481983884960378E-4 cellular amino acid metabolic process GO:0044271 0.0019490044828478232 cellular nitrogen compound biosynthetic process GO:0006082 0.0020347882312349097 organic acid metabolic process GO:0042180 0.0023948390027555668 cellular ketone metabolic process GO:0034976 0.003921568627451086 response to endoplasmic reticulum stress GO:0006142 0.00881057268722452 regulation of pyrimidine base metabolic process Set65a: PHD1 UME6 2 GO:0016049 7.537372806834754E-4 cell growth GO:0040007 0.0015492594070577977 growth GO:0034389 0.004184100418409662 lipid particle organization GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set65b: RIM4 YMR018W IRC15 STP4 GAC1 ARO9 ROX1 ACH1 MSC6 YPR063C SPL2 GDS1 SIT4 SCW10 SWI1 FKS3 16 GO:0000003 0.002630254432852438 reproduction GO:0048610 0.0054608825754151125 cellular process involved in reproduction GO:0022414 0.006174265973264165 reproductive process GO:0033692 0.008778885484249798 cellular polysaccharide biosynthetic process Set66a: HAP4 HAP1 2 GO:0043467 0.0012535612535609821 regulation of generation of precursor metabolites and energy GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0045990 0.0032510713757940256 carbon catabolite regulation of transcription GO:0000429 0.004136789851075142 carbon catabolite regulation of transcription from RNA polymerase II promoter GO:0000436 0.00654511453950429 carbon catabolite activation of transcription from RNA polymerase II promoter GO:0006091 0.0067283352310704946 generation of precursor metabolites and energy GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set66b: COX8 SMF2-A COX6 YNG1 COX4 COX7 YBL044W COR1 CYT1 COX13 10 GO:0045277 3.063166228664691E-11 respiratory chain complex IV GO:0070469 4.556032909020844E-11 respiratory chain GO:0019866 3.7586489171562624E-9 organelle inner membrane GO:0006818 2.5425593492429117E-8 hydrogen transport GO:0044455 3.037518346055029E-8 mitochondrial membrane part GO:0006091 1.4497237820480627E-7 generation of precursor metabolites and energy GO:0031975 2.5846207384344497E-7 envelope GO:0055085 8.272217145801056E-7 transmembrane transport GO:0016675 1.0230666933753105E-6 oxidoreductase activity, acting on a heme group of donors GO:0015002 1.0230666933753105E-6 heme-copper terminal oxidase activity GO:0031967 1.7148470976256642E-6 organelle envelope GO:0005746 2.4666523550998437E-6 mitochondrial respiratory chain GO:0055114 7.405701535774297E-6 oxidation-reduction process GO:0044429 9.498680133412607E-6 mitochondrial part GO:0005215 1.704139562374574E-5 transporter activity GO:0034654 1.8566305605853125E-5 nucleobase-containing compound biosynthetic process GO:0006119 2.3178838522836792E-5 oxidative phosphorylation GO:0006811 2.7419844390704984E-5 ion transport GO:0018130 2.8212977751240595E-5 heterocycle biosynthetic process GO:0022900 4.3045378206467594E-5 electron transport chain GO:0031966 1.1531098505460854E-4 mitochondrial membrane GO:0031090 1.2092093501108817E-4 organelle membrane GO:0072522 1.672377835532635E-4 purine-containing compound biosynthetic process GO:0009142 1.7158366523507446E-4 nucleoside triphosphate biosynthetic process GO:0005739 1.8678459416354105E-4 mitochondrion GO:0009145 2.2540776966561933E-4 purine nucleoside triphosphate biosynthetic process GO:0009201 2.3624468166876656E-4 ribonucleoside triphosphate biosynthetic process GO:0009206 2.4771287009928394E-4 purine ribonucleoside triphosphate biosynthetic process GO:0045275 2.981823126824689E-4 respiratory chain complex III GO:0044271 3.2970932508243685E-4 cellular nitrogen compound biosynthetic process GO:0015980 5.355177377021318E-4 energy derivation by oxidation of organic compounds GO:0051234 5.420302212140323E-4 establishment of localization GO:0032991 5.823539810199523E-4 macromolecular complex GO:0005751 5.870720553701648E-4 mitochondrial respiratory chain complex IV GO:0016491 5.992703220019945E-4 oxidoreductase activity GO:0044425 6.729647804555948E-4 membrane part GO:0051179 8.600368343536724E-4 localization GO:0009260 9.285221310089383E-4 ribonucleotide biosynthetic process GO:0009152 9.702877949340524E-4 purine ribonucleotide biosynthetic process GO:0006164 0.0012018879194513883 purine nucleotide biosynthetic process GO:0006754 0.0016813167364757185 ATP biosynthetic process GO:0009165 0.0016866180119036733 nucleotide biosynthetic process GO:0006793 0.0018034901829204993 phosphorus metabolic process GO:0016020 0.0021047447856489417 membrane GO:0043167 0.002230476898477306 ion binding GO:0034220 0.002699426039807481 ion transmembrane transport GO:0072521 0.003383525917609975 purine-containing compound metabolic process GO:0055086 0.003933577006469297 nucleobase-containing small molecule metabolic process GO:0044446 0.0044626863207740085 intracellular organelle part GO:0004129 0.005413703943115691 cytochrome-c oxidase activity GO:0044422 0.008120927113421071 organelle part GO:0046483 0.009009222450684837 heterocycle metabolic process Set67a: CIN5 ROX1 SKO1 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0000988 0.004331065137782144 protein binding transcription factor activity Set67b: GAC1 PMC1 RHO5 YPR013C RPS3 PMA1 PMC1-A YGL007C-A 8 Set68a: MSN2 PHO2 MOT3 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0071214 0.0027648611285658476 cellular response to abiotic stimulus GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0071470 0.005366726296958866 cellular response to osmotic stress GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set68b: PRB1 ISU1 GIP3 CUP9 4 GO:0051051 0.00867052023121341 negative regulation of transport Set69a: MBP1 ABF1 2 Set69b: PHO2 RFA2 EMW1 LSM4 RLF2 RBA50 ECM33 SLM4 SWI4 NSE4 DSS4 11 GO:0044427 0.0033031448786786373 chromosomal part GO:0017069 0.009345794392523593 snRNA binding Set70a: YAP6 XBP1 ROX1 DIG1 SOK2 5 GO:0001071 2.803016809767777E-4 nucleic acid binding transcription factor activity GO:0050789 0.0034359642741450124 regulation of biological process GO:0031323 0.0039920825848957795 regulation of cellular metabolic process GO:0050794 0.004816993208620784 regulation of cellular process GO:0019222 0.005024513196411015 regulation of metabolic process GO:0080090 0.0053941290632051634 regulation of primary metabolic process GO:0065007 0.005794872088728441 biological regulation GO:0016049 0.007152738541015031 cell growth GO:0032774 0.008836303150255957 RNA biosynthetic process GO:0048519 0.009470508493640681 negative regulation of biological process GO:0051171 0.009712382968487908 regulation of nitrogen compound metabolic process Set70b: PHD1 CBF2 TPO2 3 GO:0031518 0.003787878787878903 CBF3 complex Set71a: ROX1 RDS1 RTG3 MSN4 4 GO:0001071 6.020583084831739E-5 nucleic acid binding transcription factor activity GO:0050896 0.003240977672130409 response to stimulus Set71b: YPR063C ZWF1 ROX1 3 Set72a: CIN5 FKH2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set72b: PST2 RPI1 RHO3 YBR053C MRH1 YRO2 6 GO:0000267 0.0014911961315974913 cell fraction GO:0005933 0.002066541564430625 cellular bud GO:0022838 0.002347417840375607 substrate-specific channel activity GO:0022803 0.0030864197530864647 passive transmembrane transporter activity GO:0005216 0.006342494714587714 ion channel activity GO:0045921 0.006896551724137712 positive regulation of exocytosis Set73a: HSF1 PHO2 2 GO:0030474 0.004608294930875325 spindle pole body duplication GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set73b: SSE2 SSA4 LST8 HSP26 HSP78 SIS1 6 GO:0006457 1.429699659679405E-5 protein folding GO:0005515 3.7806778794982046E-4 protein binding GO:0019538 0.0027625952741341907 protein metabolic process GO:0050896 0.0037000260635312913 response to stimulus GO:0044270 0.004677698365550104 cellular nitrogen compound catabolic process GO:0071806 0.005695509309967434 protein transmembrane transport GO:0031932 0.006066734074823054 TORC2 complex GO:0034655 0.006943971610563111 nucleobase-containing compound catabolic process Set74a: ABF1 HAP1 2 Set74b: SPT23 PET10 FAS1 RTN1 RAM2 LYS4 6 GO:0031300 0.0013531872105091774 intrinsic to organelle membrane GO:0016053 0.001688677624048823 organic acid biosynthetic process GO:0044283 0.0035889305541938173 small molecule biosynthetic process GO:0005811 0.005266490172860567 lipid particle GO:0005953 0.006066734074823054 CAAX-protein geranylgeranyltransferase complex GO:0016829 0.006969774809486776 lyase activity GO:0031301 0.008190618019358784 integral to organelle membrane Set75a: SFP1 YAP5 2 GO:0034395 0.006849315068493371 regulation of transcription from RNA polymerase II promoter in response to iron GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set75b: RPL23B snR17a SLX8 RPS18B RPS6A RPL33B 6 GO:0030529 1.494931996114889E-4 ribonucleoprotein complex GO:0044445 3.452012866152496E-4 cytosolic part GO:0005198 3.4524851019617474E-4 structural molecule activity GO:0043228 6.279662873265523E-4 non-membrane-bounded organelle GO:0043232 6.279662873265523E-4 intracellular non-membrane-bounded organelle GO:0032991 9.28790464896329E-4 macromolecular complex GO:0044391 0.0020110736347657837 ribosomal subunit GO:0005840 0.0022012373240585764 ribosome GO:0005829 0.003778687810017465 cytosol GO:0044422 0.007610320101702211 organelle part GO:0090305 0.008979551287822915 nucleic acid phosphodiester bond hydrolysis Set76a: HAP1 SOK2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set76b: FET3 YOL114C ERG25 SKM1 AAC1 ERG28 6 GO:0044107 0.002373898582796979 cellular alcohol metabolic process GO:0016020 0.003541506523905584 membrane GO:0044108 0.0035433500349547277 cellular alcohol biosynthetic process GO:0033573 0.007692307692307591 high affinity iron permease complex Set77a: DIG1 OPI1 GZF3 YAP7 YHL009C PDR1 6 GO:0001071 7.831405570476672E-4 nucleic acid binding transcription factor activity GO:0050789 0.0010985320947536645 regulation of biological process GO:0031323 0.0013129300734310142 regulation of cellular metabolic process GO:0050794 0.0016475372960281444 regulation of cellular process GO:0019222 0.0017315787300720689 regulation of metabolic process GO:0080090 0.001884442490912388 regulation of primary metabolic process GO:0065007 0.002058569125659108 biological regulation GO:0032774 0.0034022992056635627 RNA biosynthetic process GO:0051171 0.0038131362710791396 regulation of nitrogen compound metabolic process GO:0009889 0.004395450539561947 regulation of biosynthetic process GO:0060255 0.005673982302805024 regulation of macromolecule metabolic process GO:0031326 0.0060816078543365 regulation of cellular biosynthetic process GO:0003676 0.0065182371316626075 nucleic acid binding GO:0019219 0.00965476391188814 regulation of nucleobase-containing compound metabolic process Set77b: BSP1 tI(AAU)P2 2 GO:0060090 0.0013385984873841498 binding, bridging Set78a: ABF1 DAL82 2 Set78b: HRB1 ANT1 SCD6 YPL179W RBA50 MRP7 6 GO:0030530 0.0077519379844957605 heterogeneous nuclear ribonucleoprotein complex Set79a: SKN7 HAP1 2 GO:0043620 0.005193385267185533 regulation of DNA-dependent transcription in response to stress GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set79b: HMX1 PUT4 OLE1 CCW12 SDS23 TSA1 ENT2 NDE1 YLR113W CIN1 10 GO:0016705 0.0031051703393602972 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016491 0.004258977183782731 oxidoreductase activity GO:0055114 0.004751698132582178 oxidation-reduction process GO:0046149 0.008771929824560584 pigment catabolic process GO:0033015 0.009708737864077497 tetrapyrrole catabolic process Set80a: REB1 MCM1 NDD1 3 Set80b: MIC17 tK(UUU)P CLB2 CDC5-A RUF1 CDC5 HLR1 7 GO:0032886 7.121379965184843E-4 regulation of microtubule-based process GO:0090068 0.0011012782694198575 positive regulation of cell cycle process GO:0031023 0.0019338279244747582 microtubule organizing center organization GO:0000073 0.003921568627451086 spindle pole body separation GO:0033043 0.004078840030525947 regulation of organelle organization GO:0007017 0.00571138739450689 microtubule-based process GO:0005819 0.0062539086929325905 spindle GO:0051300 0.007703081232493212 spindle pole body organization Set81a: HAP5 ROX1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set81b: SED1 SIT4 ATP1 STP4 PRB1 TIM23 ACC1 7 GO:0045267 0.006616257088847775 proton-transporting ATP synthase, catalytic core GO:0005739 0.008148677911902984 mitochondrion Set82a: MBP1 SWI4 STE12 ACE2 PHD1 5 GO:0001071 5.181868316132538E-6 nucleic acid binding transcription factor activity GO:0048518 2.354697059017266E-5 positive regulation of biological process GO:0048522 4.319218940071446E-5 positive regulation of cellular process GO:0009893 0.002025173565607088 positive regulation of metabolic process GO:0031325 0.002446983208721204 positive regulation of cellular metabolic process GO:0050789 0.0034359642741450124 regulation of biological process GO:0031323 0.0039920825848957795 regulation of cellular metabolic process GO:0050794 0.004816993208620784 regulation of cellular process GO:0019222 0.005024513196411015 regulation of metabolic process GO:0080090 0.0053941290632051634 regulation of primary metabolic process GO:0005667 0.005628517823639318 transcription factor complex GO:0065007 0.005794872088728441 biological regulation GO:0001067 0.006954501118574408 regulatory region nucleic acid binding GO:0016049 0.007152738541015031 cell growth GO:0051173 0.007186176588966426 positive regulation of nitrogen compound metabolic process GO:0010604 0.007996427149540975 positive regulation of macromolecule metabolic process GO:0032774 0.008836303150255957 RNA biosynthetic process GO:0051171 0.009712382968487908 regulation of nitrogen compound metabolic process Set82b: YSY6 YDR524W-A TOS1 AGE1 EXO5 RBA50 SNA2 AGE1-B 8 Set83a: CBF1 RAP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set83b: RPS4A PFK27 CAP1 LAC1 YJL133C-A MRS3 RPL11A YHR033W HMS2 PRE2 10 GO:0008290 0.007220216606497868 F-actin capping protein complex Set84a: RAP1 SKN7 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set84b: RPS15 MAM3 TNA1 RAD2 GPD2 RPP2A RPL12A 7 GO:0006072 0.0075187969924814975 glycerol-3-phosphate metabolic process GO:0035353 0.0095238095238093 nicotinamide mononucleotide transmembrane transport Set85a: GLN3 FHL1 2 GO:0032545 0.00303951367781151 CURI complex GO:0042126 0.007511717145976385 nitrate metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set85b: SEC10 RPS20-A DUR3 RPS20 RPS31 5 GO:0019627 0.0031545741324918346 urea metabolic process GO:0015935 0.0036830807980807946 small ribosomal subunit GO:0000145 0.003759398496240955 exocyst GO:0031386 0.0070639969327868065 protein tag GO:0022406 0.0079720678523083 membrane docking GO:0071918 0.009433962264151104 urea transmembrane transport Set86a: SWI6 SNT2 2 Set86b: SRS2 THI22 tC(GCA)P2 TOK1 YPR120C 5 GO:0071804 0.004990019960075383 cellular potassium ion transport Set87a: RME1 NDD1 2 Set87b: RGT1 AIM38 snR69 RUP1 SFL1 5 Set88a: YAP5 REB1 2 Set88b: CLB3 IRC23 PET111 YKL072W SUI2 5 GO:0033043 0.004078840030525947 regulation of organelle organization GO:0005850 0.004518072289156083 eukaryotic translation initiation factor 2 complex GO:0051128 0.00763425380622143 regulation of cellular component organization GO:0045182 0.008826083894748446 translation regulator activity Set89a: RLM1 SKO1 XBP1 3 Set89b: IME2 YJL107C SED1 3 Set90a: ADR1 MET31 DAL82 MAC1 MET4 5 GO:0001071 5.181868316132538E-6 nucleic acid binding transcription factor activity GO:0000988 5.211258204239408E-4 protein binding transcription factor activity GO:0048518 9.110180212425138E-4 positive regulation of biological process GO:0048522 0.0014600268871665743 positive regulation of cellular process GO:0009893 0.002025173565607088 positive regulation of metabolic process GO:0031325 0.002446983208721204 positive regulation of cellular metabolic process GO:0009896 0.0033526786876179986 positive regulation of catabolic process GO:0050789 0.0034359642741450124 regulation of biological process GO:0031323 0.0039920825848957795 regulation of cellular metabolic process GO:0050794 0.004816993208620784 regulation of cellular process GO:0019222 0.005024513196411015 regulation of metabolic process GO:0080090 0.0053941290632051634 regulation of primary metabolic process GO:0065007 0.005794872088728441 biological regulation GO:0001067 0.006954501118574408 regulatory region nucleic acid binding GO:0051173 0.007186176588966426 positive regulation of nitrogen compound metabolic process GO:0010565 0.007792044496322106 regulation of cellular ketone metabolic process GO:0010604 0.007996427149540975 positive regulation of macromolecule metabolic process GO:0032774 0.008836303150255957 RNA biosynthetic process GO:0051171 0.009712382968487908 regulation of nitrogen compound metabolic process Set90b: GLC7 snR52 2 GO:0072690 0.003990021954094283 vegetative growth of a single-celled organism GO:0005849 0.004048582995951182 mRNA cleavage factor complex GO:0000164 0.0072727272727264305 protein phosphatase type 1 complex Set91a: SWI5 CBF1 2 GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set91b: UBC4 TEC1 BMH1 PSK1 ERG25 YAL018C YHR033W 7 GO:0033692 0.002729560323104229 cellular polysaccharide biosynthetic process GO:0000271 0.003137206443920947 polysaccharide biosynthetic process GO:0044264 0.004614561389134947 cellular polysaccharide metabolic process GO:0005976 0.006739985861703883 polysaccharide metabolic process GO:0010530 0.006993006993006685 positive regulation of transposition GO:0051439 0.008196721311475488 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Set92a: SWI4 MOT3 SKO1 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0071214 0.0027648611285658476 cellular response to abiotic stimulus GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0071470 0.005366726296958866 cellular response to osmotic stress GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set92b: GAC1 MGA1 SOK2 UTH1 SPO20 5 Set93a: UME6 BAS1 2 GO:0034389 0.004184100418409662 lipid particle organization GO:0022414 0.006267458510370168 reproductive process GO:0048610 0.007986025950098693 cellular process involved in reproduction GO:0000003 0.009381626409405661 reproduction GO:0051039 0.0095238095238093 positive regulation of transcription during meiosis Set93b: PAC1 STR3 HRK1 HSC82 JEN1 SRY1 6 Set94a: RAP1 REB1 2 Set94b: CSR2 EHD3 GEA2 YEL023C KRS1 ECM19-A APL4 7 GO:0016192 0.0017693006152811818 vesicle-mediated transport GO:0044431 0.006300580848470232 Golgi apparatus part GO:0030119 0.008086223875701525 AP-type membrane coat adaptor complex GO:0031984 0.009679317446310847 organelle subcompartment Set95a: RAP1 NDD1 2 Set95b: snR40 COT1 COT1-A YGR143W TDH3 FAA1 CAF40 7 GO:0005811 0.0010887976433285695 lipid particle GO:0035383 0.006257822277842747 thioester metabolic process GO:0034637 0.007467343423006204 cellular carbohydrate biosynthetic process GO:0030015 0.008097165991902366 CCR4-NOT core complex GO:0016051 0.008687690073926205 carbohydrate biosynthetic process Set96a: INO4 PHO2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set96b: CHO2 YBR085C-A YPR013C TPI1 FBA1 5 GO:0034637 0.007467343423006204 cellular carbohydrate biosynthetic process GO:0016051 0.008687690073926205 carbohydrate biosynthetic process GO:0006066 0.009806162173836612 alcohol metabolic process Set97a: PHO2 DAL82 NDD1 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set97b: CWP2 PST2 YKL096C-B MRH1 4 GO:0005576 0.005371310770796439 extracellular region GO:0044425 0.005552733281831514 membrane part Set98a: GLN3 MOT3 TEC1 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051716 0.008384515738521489 cellular response to stimulus GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set98b: RHO3 RPI1 snR61 3 GO:0045921 0.006896551724137712 positive regulation of exocytosis GO:0009110 0.009861932938853946 vitamin biosynthetic process Set99a: HAP4 SKN7 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set99b: SDH1 YLR297W ATP1 ATP14 AVT3 5 GO:0055085 1.1313359968281694E-4 transmembrane transport GO:0031090 4.2438171678979694E-4 organelle membrane GO:0034654 5.510422041687975E-4 nucleobase-containing compound biosynthetic process GO:0045259 5.695954078513249E-4 proton-transporting ATP synthase complex GO:0018130 7.011471369957516E-4 heterocycle biosynthetic process GO:0019866 0.0010770110462931823 organelle inner membrane GO:0044425 0.0015064359736804542 membrane part GO:0016469 0.002424629940567986 proton-transporting two-sector ATPase complex GO:0006818 0.0027445940014239074 hydrogen transport GO:0044271 0.003077058570757809 cellular nitrogen compound biosynthetic process GO:0016020 0.003541506523905584 membrane GO:0005215 0.004623272506471952 transporter activity GO:0045281 0.004725897920600487 succinate dehydrogenase complex GO:0045283 0.004725897920600487 fumarate reductase complex GO:0045267 0.004725897920600487 proton-transporting ATP synthase, catalytic core GO:0045273 0.004725897920600487 respiratory chain complex II GO:0072522 0.0058587171915753765 purine-containing compound biosynthetic process GO:0031975 0.005907713433625028 envelope GO:0009142 0.006237216743282153 nucleoside triphosphate biosynthetic process GO:0044455 0.006358326228298574 mitochondrial membrane part GO:0046483 0.007327722685779042 heterocycle metabolic process GO:0009145 0.007335638819819827 purine nucleoside triphosphate biosynthetic process GO:0009201 0.007543251239248777 ribonucleoside triphosphate biosynthetic process GO:0009206 0.007758772703227104 purine ribonucleoside triphosphate biosynthetic process GO:0051234 0.009377229172570067 establishment of localization Set100a: STE12 INO2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set100b: SAM35 KSP1 RHO5 RPS3 TIM23 ACC1 6 GO:0051641 0.003167831096361426 cellular localization GO:0001401 0.007692307692307168 mitochondrial sorting and assembly machinery complex Set101a: SOK2 MAC1 SUT1 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity Set101b: LSM5 YKL063C FTR1 MSN4 CUP9 5 GO:0033573 0.007692307692307591 high affinity iron permease complex Set102a: MBP1 SWI4 GCN4 PHD1 4 GO:0001071 6.020583084831739E-5 nucleic acid binding transcription factor activity GO:0048518 2.0104118072084663E-4 positive regulation of biological process GO:0048522 3.2655912895425713E-4 positive regulation of cellular process GO:0009893 4.5765085988733206E-4 positive regulation of metabolic process GO:0031325 5.56609914430763E-4 positive regulation of cellular metabolic process GO:0051173 0.0017103808914118003 positive regulation of nitrogen compound metabolic process GO:0010604 0.0019142550561718134 positive regulation of macromolecule metabolic process GO:0009891 0.002519625238377181 positive regulation of biosynthetic process GO:0031328 0.002790657755469802 positive regulation of cellular biosynthetic process GO:0045935 0.003247105670396677 positive regulation of nucleobase-containing compound metabolic process GO:0010628 0.0050883905597982095 positive regulation of gene expression GO:0005667 0.005628517823639318 transcription factor complex GO:0010557 0.00838050437132659 positive regulation of macromolecule biosynthetic process Set102b: GID8 ICY1 GAT2 CMC4 4 GO:0034657 0.004044489383216766 GID complex Set103a: HAP1 FKH1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set103b: RGT1 snR69 JEN1 IDI1 HOS3 SRY1 6 Set104a: STP1 RTG3 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set104b: DIP5 YBL104C GNP1 SMT3 4 GO:0031386 0.0070639969327868065 protein tag GO:0071944 0.009353969292453596 cell periphery Set105a: YAP5 MSN4 2 GO:0071241 0.001120238984316606 cellular response to inorganic substance GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set105b: RTC3 ENO1 PUP2 NAM8-A 4 GO:0019773 0.00606059365571654 proteasome core complex, alpha-subunit complex GO:0000015 0.006578947368420024 phosphopyruvate hydratase complex Set106a: MBP1 STB5 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set106b: TOF1 GOR1 BNR1 POT1 4 GO:0016054 0.004809894640402144 organic acid catabolic process GO:0005522 0.005494505494505476 profilin binding Set107a: CBF1 RDS1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set107b: MNN2 YBR016W BUD27 EPL1 4 GO:0016272 0.006578947368420024 prefoldin complex Set108a: MCM1 GCR2 2 Set108b: MMR1 ATG26 CDC6 ELO1 4 Set109a: DAL82 GCR2 2 Set109b: RFC5 IST2 SYS1 COX16 4 GO:0005663 0.003787878787878903 DNA replication factor C complex GO:0031391 0.003787878787878903 Elg1 RFC-like complex GO:0031390 0.003787878787878903 Ctf18 RFC-like complex GO:0031389 0.003787878787878903 Rad17 RFC-like complex GO:0003689 0.005494505494505476 DNA clamp loader activity Set110a: REB1 HAP2 2 Set110b: tG(GCC)G2 FMP43 YAP1802 CRM1 4 GO:0044430 0.008793881703582153 cytoskeletal part Set111a: PHO4 AFT2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set111b: APT2 PHO89 MAL33 PHO89-A 4 Set112a: XBP1 AFT2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set112b: YNL193W YNL194C tK(UUU)P CLB2 4 Set113a: HSF1 MOT3 2 GO:0030474 0.004608294930875325 spindle pole body duplication Set113b: SSA1 snR18 EFB1 YGR142W 4 GO:0030529 0.0068433855687600915 ribonucleoprotein complex Set114a: STP1 MSN2 SKN7 BAS1 4 GO:0001071 0.0025913081073285975 nucleic acid binding transcription factor activity Set114b: TPO4 MOD5 2 Set115a: CBF1 UME6 MCM1 NDD1 4 GO:0000988 2.1428507003319077E-4 protein binding transcription factor activity GO:0044427 0.002157421624681818 chromosomal part GO:0001071 0.0025913081073285975 nucleic acid binding transcription factor activity GO:0005515 0.005314620789852395 protein binding GO:0048518 0.006217160724096565 positive regulation of biological process GO:0034389 0.008368200836818863 lipid particle organization GO:0048522 0.008831828472544836 positive regulation of cellular process Set115b: SFB3 TRA1 2 Set116a: HAP5 PHD1 SUT1 YAP6 4 GO:0001071 6.020583084831739E-5 nucleic acid binding transcription factor activity GO:0048518 2.0104118072084663E-4 positive regulation of biological process GO:0048522 3.2655912895425713E-4 positive regulation of cellular process GO:0009893 4.5765085988733206E-4 positive regulation of metabolic process GO:0031325 5.56609914430763E-4 positive regulation of cellular metabolic process GO:0051173 0.0017103808914118003 positive regulation of nitrogen compound metabolic process GO:0010604 0.0019142550561718134 positive regulation of macromolecule metabolic process GO:0009891 0.002519625238377181 positive regulation of biosynthetic process GO:0031328 0.002790657755469802 positive regulation of cellular biosynthetic process GO:0045935 0.003247105670396677 positive regulation of nucleobase-containing compound metabolic process GO:0010628 0.0050883905597982095 positive regulation of gene expression GO:0010557 0.00838050437132659 positive regulation of macromolecule biosynthetic process Set116b: TIR3 PDR11 2 Set117a: STB2 ABF1 CST6 RCS1 4 Set117b: ALG1 CMD1 2 GO:0044450 0.003616636528029585 microtubule organizing center part GO:0044255 0.003661258837925632 cellular lipid metabolic process GO:0048306 0.005494505494505476 calcium-dependent protein binding GO:0006629 0.006809315521930216 lipid metabolic process Set118a: YAP6 HSF1 ROX1 PHO4 4 GO:0001071 6.020583084831739E-5 nucleic acid binding transcription factor activity GO:0048519 0.0041002021474272135 negative regulation of biological process GO:0030474 0.004608294930875325 spindle pole body duplication GO:0048523 0.00527437432826523 negative regulation of cellular process GO:0000988 0.008447845205531702 protein binding transcription factor activity Set118b: ECL1 ECL1-A 2 Set119a: CBF1 HAP4 REB1 HAP3 4 GO:0001071 0.0025913081073285975 nucleic acid binding transcription factor activity GO:0048518 0.006217160724096565 positive regulation of biological process GO:0043467 0.00721414220404488 regulation of generation of precursor metabolites and energy GO:0000988 0.008447845205531702 protein binding transcription factor activity GO:0048522 0.008831828472544836 positive regulation of cellular process Set119b: YML119W NDI1 2 GO:0010941 0.005681818181817997 regulation of cell death GO:0008219 0.008982035928142435 cell death Set120a: ABF1 TEC1 2 Set120b: UME6 COY1 snR61 MSS4 4 GO:0019637 0.0031589946237616383 organophosphate metabolic process GO:0034389 0.004184100418409662 lipid particle organization GO:0051039 0.0095238095238093 positive regulation of transcription during meiosis GO:0045896 0.00990099009900975 regulation of transcription during mitosis Set121a: RAP1 PHO2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set121b: RPS13 TDH3 HIS4 RPS11B NOB1 GPM1 ACA1 SPO73 ATG19 YHR122W SGT1 11 GO:0051287 0.0024132332938440106 NAD binding GO:0030674 0.00417716949614989 protein binding, bridging GO:0070181 0.007936507936507959 SSU rRNA binding Set122a: GCN4 REB1 2 GO:2000144 0.008130081300812846 positive regulation of transcription initiation, DNA-dependent Set122b: HVG1-A MRPS17 IRC23 HVG1 GLN3 GCV2 6 GO:0042126 0.007511717145976385 nitrate metabolic process Set123a: RAP1 CHA4 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set123b: LAC1 YNL010W SAP1 YNL011C CAP1 5 GO:0008290 0.0036101083032491327 F-actin capping protein complex GO:0046467 0.007889546351083158 membrane lipid biosynthetic process GO:0032271 0.00867052023121341 regulation of protein polymerization Set124a: SWI5 SWI6 SOK2 3 Set124b: PHD1 YGR189C EXG1 3 GO:0005576 0.00273892945580637 extracellular region GO:0005976 0.003442935359539943 polysaccharide metabolic process GO:0030312 0.003700806538174563 external encapsulating structure GO:0016798 0.005712133576046458 hydrolase activity, acting on glycosyl bonds Set125a: HAP1 REB1 2 Set125b: COX13 ASK1 CYB5 SFK1 4 GO:0006091 0.0067283352310704946 generation of precursor metabolites and energy GO:0006629 0.006809315521930216 lipid metabolic process GO:0042729 0.007662835249040994 DASH complex GO:0008610 0.009269356597604242 lipid biosynthetic process Set126a: CAD1 YAP7 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set126b: NFU1 LSB6 DRE2 YHB1 LAP4 HSL1 PHO81 MRS4 PTM1 TAH18 CYT2 GSH1 CCS1 SRX1 14 GO:0051188 2.6156171277838796E-4 cofactor biosynthetic process GO:0031970 8.077295391782595E-4 organelle envelope lumen GO:0044429 0.002322767288884621 mitochondrial part GO:0016209 0.004877865498842123 antioxidant activity GO:0043167 0.008341238197262766 ion binding GO:0006979 0.008681173862477583 response to oxidative stress Set127a: GCR1 GCR2 ROX1 YOR344C PHD1 STE12 SNT2 7 GO:0001071 9.391607091328341E-5 nucleic acid binding transcription factor activity GO:0043471 9.710578329323091E-5 regulation of cellular carbohydrate catabolic process GO:0048522 2.3077712431061328E-4 positive regulation of cellular process GO:0009893 3.4769872765100175E-4 positive regulation of metabolic process GO:0048518 4.0335305376688457E-4 positive regulation of biological process GO:0031325 4.411400091743416E-4 positive regulation of cellular metabolic process GO:0010675 5.402979160492836E-4 regulation of cellular carbohydrate metabolic process GO:0043470 5.844535359439019E-4 regulation of carbohydrate catabolic process GO:0043467 7.2835248668015E-4 regulation of generation of precursor metabolites and energy GO:0006109 8.753028164774346E-4 regulation of carbohydrate metabolic process GO:0016052 0.0011055540931822025 carbohydrate catabolic process GO:0044428 0.0012594230417950197 nuclear part GO:0031323 0.0013129300734310142 regulation of cellular metabolic process GO:0044282 0.001317978244228108 small molecule catabolic process GO:0072361 0.001378929950358516 regulation of glycolysis by regulation of transcription from RNA polymerase II promoter GO:0072363 0.0014333492594362004 regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter GO:0050794 0.0016475372960281444 regulation of cellular process GO:0019222 0.0017315787300720689 regulation of metabolic process GO:0080090 0.001884442490912388 regulation of primary metabolic process GO:0010604 0.0019601684334308515 positive regulation of macromolecule metabolic process GO:0006110 0.0019762845849802227 regulation of glycolysis GO:0032774 0.0034022992056635627 RNA biosynthetic process GO:0051171 0.0038131362710791396 regulation of nitrogen compound metabolic process GO:0006096 0.00401899890390935 glycolysis GO:0060963 0.00423634336677817 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0009889 0.004395450539561947 regulation of biosynthetic process GO:0031329 0.004785502359976791 regulation of cellular catabolic process GO:0009894 0.0053955147725963165 regulation of catabolic process GO:0050789 0.005586401879189182 regulation of biological process GO:0060255 0.005673982302805024 regulation of macromolecule metabolic process GO:0031326 0.0060816078543365 regulation of cellular biosynthetic process GO:0006091 0.008999067809502997 generation of precursor metabolites and energy GO:0060962 0.00905781365606931 regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0019219 0.00965476391188814 regulation of nucleobase-containing compound metabolic process GO:0006066 0.009806162173836612 alcohol metabolic process Set127b: CDC19 CYC3 2 Set128a: REB1 YRR1 2 Set128b: NOP8 CTR9 PRP22 SOG2 4 GO:0000386 0.002136752136752216 second spliceosomal transesterification activity GO:0009302 0.004629629629629636 snoRNA transcription GO:2001207 0.004926108374384399 regulation of transcription elongation from RNA polymerase I promoter GO:0001015 0.006493506493506457 snoRNA transcription from an RNA polymerase II promoter GO:0008023 0.00809716599190192 transcription elongation factor complex Set129a: GCN4 SUM1 2 GO:0010944 3.702332469455773E-4 negative regulation of transcription by competitive promoter binding GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:2000144 0.008130081300812846 positive regulation of transcription initiation, DNA-dependent Set129b: YJR027W YJR026W ORC3 SPO75 BNA1 YGL170C SUA5 7 GO:0000943 0.0010967416689815052 retrotransposon nucleocapsid GO:0032196 0.001149206094412552 transposition GO:0006259 0.004381141455313292 DNA metabolic process GO:0032502 0.007198731082707747 developmental process Set130a: STE12 TEC1 FKH2 3 GO:0016049 1.9597169297765377E-5 cell growth GO:0040007 5.900633702700491E-5 growth GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0000988 0.004331065137782144 protein binding transcription factor activity GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set130b: SIM1 FRT2 BUD8 YOR246C MYO4 SRL1 6 GO:0016459 0.0036101083032491327 myosin complex GO:0031941 0.0036101083032491327 filamentous actin GO:0005933 0.003950437478893611 cellular bud GO:0030427 0.005265051152461298 site of polarized growth GO:0009986 0.005535055350551623 cell surface Set131a: SFP1 MSN4 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set131b: snR18 TEM1 SSA1 RPS1B RPS5 RPL11A EFB1 PRE2 8 GO:0030529 7.496298053916873E-5 ribonucleoprotein complex GO:0044445 7.61940081291619E-4 cytosolic part GO:0032991 0.0016805958485290068 macromolecular complex GO:0071840 0.005366472563467287 cellular component organization or biogenesis GO:0006412 0.005988458776399072 translation GO:0071841 0.0073288058408922906 cellular component organization or biogenesis at cellular level GO:0005840 0.008526947838183587 ribosome GO:0043228 0.009955122871843164 non-membrane-bounded organelle GO:0043232 0.009955122871843164 intracellular non-membrane-bounded organelle Set132a: RTG3 SUT1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set132b: HAP4 PDR16 ECM13 IDH2 ACS1 KTI12 FLC2 7 GO:0006091 0.004781510351306706 generation of precursor metabolites and energy GO:0035350 0.0095238095238093 FAD transmembrane transport Set133a: CBF1 INO4 2 GO:0044255 0.003661258837925632 cellular lipid metabolic process GO:0006629 0.006809315521930216 lipid metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process GO:0008610 0.009269356597604242 lipid biosynthetic process Set133b: RPI1 RHO3 STE20 IES5 ERG20 SAH1 SET2 MET6 8 GO:0006790 0.0013675347006611262 sulfur compound metabolic process GO:0006730 0.0018283527908426725 one-carbon metabolic process GO:0010638 0.0019850448968830934 positive regulation of organelle organization GO:0051130 0.002414871752920223 positive regulation of cellular component organization GO:0009300 0.004672897196261788 antisense RNA transcription GO:0060194 0.004950495049504874 regulation of antisense RNA transcription GO:0000267 0.007404261356075476 cell fraction GO:0001887 0.008760951188989239 selenium compound metabolic process GO:0003824 0.009278048887047531 catalytic activity GO:0032268 0.009977885891202635 regulation of cellular protein metabolic process Set134a: NRG1 ASH1 2 GO:0016049 7.537372806834754E-4 cell growth GO:0040007 0.0015492594070577977 growth GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set134b: HAP4 SED1 ELO1 GID8 GAT2 UTR2 KTI12 CDC6 8 GO:0003682 0.002738607338988672 chromatin binding GO:0034657 0.007077856420629176 GID complex Set135a: YAP6 SFP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set135b: SED1 RPL23A snR40 HMS1 YOR032W-A CAF40 6 GO:0030015 0.008097165991902366 CCR4-NOT core complex Set136a: STP1 GLN3 GCN4 3 GO:0019740 2.568376607803346E-4 nitrogen utilization GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0009719 7.653409867431321E-4 response to endogenous stimulus GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0006808 0.0019914960404520234 regulation of nitrogen utilization GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0090293 0.004015429849727145 nitrogen catabolite regulation of transcription GO:0001079 0.004172571248622252 nitrogen catabolite regulation of transcription from RNA polymerase II promoter GO:0090294 0.005189309015794733 nitrogen catabolite activation of transcription GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set136b: RRI2 QDR3 MCH4 3 GO:0008180 0.00303951367781151 signalosome Set137a: ACE2 RAP1 2 GO:2001041 0.0057803468208086255 regulation of cytokinetic cell separation involved in cell cycle cytokinesis GO:2001043 0.0073529411764705266 positive regulation of cytokinetic cell separation involved in cell cycle cytokinesis GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set137b: RPS4A YGR283C YKL151C MCR1 HMS2 CTS1 6 GO:0001871 0.0029850746268659956 pattern binding Set138a: MSN2 RGT1 STE12 SKN7 IXR1 5 GO:0001071 2.803016809767777E-4 nucleic acid binding transcription factor activity GO:0050789 0.0034359642741450124 regulation of biological process GO:0031323 0.0039920825848957795 regulation of cellular metabolic process GO:0050794 0.004816993208620784 regulation of cellular process GO:0019222 0.005024513196411015 regulation of metabolic process GO:0080090 0.0053941290632051634 regulation of primary metabolic process GO:0065007 0.005794872088728441 biological regulation GO:0051716 0.007093319392631317 cellular response to stimulus GO:0032774 0.008836303150255957 RNA biosynthetic process GO:0048519 0.009470508493640681 negative regulation of biological process GO:0051171 0.009712382968487908 regulation of nitrogen compound metabolic process Set138b: YKR075C ECM4 2 GO:0006518 0.008760951188986421 peptide metabolic process Set139a: MSN2 SOK2 DAL80 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity Set139b: KNH1 CIN5 DFG16 3 Set140a: MSN2 UME6 2 GO:0032502 0.003999906105494663 developmental process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0034389 0.008368200836818863 lipid particle organization Set140b: CUE4 TSL1-A DMC1 TSL1 YCR061W YIH1 6 GO:0005946 0.0030120481927717623 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) GO:0000709 0.008333333333333401 meiotic joint molecule formation Set141a: ARG80 STE12 2 Set141b: YER048C YOX1 UBC4 TEC1 CUP9 tQ(UUG)E1 6 GO:0000988 0.0010139058887696387 protein binding transcription factor activity GO:0005515 0.006632206110645157 protein binding GO:0010530 0.006993006993006685 positive regulation of transposition Set142a: SPT23 SWI6 2 Set142b: YNK1 tH(GUG)K SPB1 3 GO:0072527 0.007626289901189465 pyrimidine-containing compound metabolic process GO:0009132 0.00787401574803151 nucleoside diphosphate metabolic process GO:0009218 0.009174311926605555 pyrimidine ribonucleotide metabolic process GO:0009147 0.009900990099009768 pyrimidine nucleoside triphosphate metabolic process Set143a: CST6 RLM1 2 Set143b: VPS74 FRQ1 snR53 3 GO:0005794 0.007362471079558774 Golgi apparatus Set144a: STB1 MOT3 2 GO:2000243 0.009615384615384361 positive regulation of reproductive process Set144b: TOS2 PET54 UTR2 3 GO:0045182 0.005300345062327155 translation regulator activity Set145a: ABF1 DIG1 MSN4 3 GO:0051716 0.008384515738521489 cellular response to stimulus Set145b: YLR454W RIF2 2 Set146a: STP1 YAP6 RLM1 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set146b: LYS9 snR49 2 Set147a: STE12 SUM1 CHA4 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity Set147b: TFB1 SUM1 2 GO:0032806 0.00303951367781151 carboxy-terminal domain protein kinase complex GO:0000441 0.004048582995951182 SSL2-core TFIIH complex Set148a: NRG1 STE12 MCM1 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0016049 0.0022220175034543205 cell growth GO:0051704 0.0030620671192335114 multi-organism process GO:0040007 0.004529765547119604 growth Set148b: NUR1 RAM1 2 GO:0005965 0.0030120481927712432 protein farnesyltransferase complex Set149a: STE12 REB1 DAL80 3 Set149b: ARF3 YOR093C 2 Set150a: STE12 GCN4 MAC1 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set150b: PRM5 HIS5 2 Set151a: MOT3 RPN4 MCM1 3 Set151b: UFD1 TFC4 2 GO:0034098 0.008376935679935055 Cdc48p-Npl4p-Ufd1p AAA ATPase complex GO:0001016 0.00925925925925929 RNA polymerase III regulatory region DNA binding GO:0000992 0.009345794392523593 polymerase III regulatory region sequence-specific DNA binding GO:0001034 0.009345794392523593 sequence-specific DNA binding RNA polymerase III transcription factor activity Set152a: MBP1 NRG1 RAP1 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0048519 0.0011099179319168585 negative regulation of biological process GO:0009892 0.0013472958361173794 negative regulation of metabolic process GO:0031324 0.0014077578122130934 negative regulation of cellular metabolic process GO:0048523 0.001438465725890594 negative regulation of cellular process GO:0051172 0.0028668339501475063 negative regulation of nitrogen compound metabolic process GO:0010605 0.003386481637834185 negative regulation of macromolecule metabolic process GO:0009890 0.003714371850900304 negative regulation of biosynthetic process GO:0031327 0.004077243694867415 negative regulation of cellular biosynthetic process GO:0045934 0.004659058756955219 negative regulation of nucleobase-containing compound metabolic process GO:0010629 0.00745623602274447 negative regulation of gene expression GO:0010558 0.00965368463846939 negative regulation of macromolecule biosynthetic process Set152b: KES1 POC4 2 Set153a: SWI5 PHO2 MSN4 3 Set153b: MRPL4 LSM3 2 Set154a: PHO2 GTS1 GCR2 3 GO:0044093 0.0015041625976809964 positive regulation of molecular function GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0048511 0.002652519893899939 rhythmic process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0000988 0.004331065137782144 protein binding transcription factor activity GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process GO:0071072 0.009803921568627428 negative regulation of phospholipid biosynthetic process Set154b: ADH1 PHM7 2 Set155a: HSF1 HAC1 AFT2 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0051716 0.008384515738521489 cellular response to stimulus GO:0030474 0.009216589861750144 spindle pole body duplication Set155b: KAR2 TAD2 2 GO:0034099 0.0034482758620686537 luminal surveillance complex Set156a: MSN2 ABF1 AFT2 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051716 0.008384515738521489 cellular response to stimulus GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set156b: SSC1 YJR046W 2 GO:0072379 0.006578947368420024 ER membrane insertion complex GO:0043335 0.00719424460431706 protein unfolding Set157a: CBF1 HSF1 REB1 3 GO:0030474 0.004608294930875325 spindle pole body duplication Set157b: BUD7 MBF1 2 GO:0034044 0.0036900369003690227 exomer complex Set158a: NRG1 PHO4 HAP2 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0007154 0.0011213935764833173 cell communication GO:0009605 0.002368573871612081 response to external stimulus GO:0031668 0.00476068553871796 cellular response to extracellular stimulus GO:0051716 0.008384515738521489 cellular response to stimulus GO:0045990 0.009428106989802806 carbon catabolite regulation of transcription Set158b: CTF19 VTC3 2 GO:0000817 0.007662835249040994 COMA complex GO:0033254 0.009022515400973773 vacuolar transporter chaperone complex Set159a: ARG80 ASH1 2 GO:2000242 0.005376344086021723 negative regulation of reproductive process GO:0051093 0.005747126436781691 negative regulation of developmental process GO:0045596 0.006849315068493371 negative regulation of cell differentiation Set159b: PCL1 SED1 YHP1 PPN1 4 GO:0048584 0.008982035928142914 positive regulation of response to stimulus GO:0010647 0.009708737864078032 positive regulation of cell communication Set160a: STB2 REB1 2 Set160b: SOG2 YUH1 YJR098C 3 Set161a: ABF1 ARR1 2 Set161b: snR55 HRB1 snR57 snR61 MRP7 5 GO:0030529 2.7681842005585777E-5 ribonucleoprotein complex GO:0043414 1.122270764912271E-4 macromolecule methylation GO:0006730 2.2700567481120538E-4 one-carbon metabolic process GO:0009451 2.691501356723505E-4 RNA modification GO:0032991 0.0029880516099231986 macromolecular complex GO:0031974 0.003797021549017607 membrane-enclosed lumen GO:0000496 0.004512333780670477 base pairing Set162a: MBP1 PHO4 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set162b: APT2 PDR8 BOP2 3 Set163a: GLN3 SKN7 2 GO:0042126 0.007511717145976385 nitrate metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set163b: AIM38 RPI1 DOT6 ICS2 RHO3 PMC1 PMA1 BAT2 ARG1 AMN1 PMC1-A YGL007C-A 12 GO:0044271 0.001019454896099712 cellular nitrogen compound biosynthetic process GO:0034655 0.005536114134482852 nucleobase-containing compound catabolic process GO:0045921 0.006896551724137712 positive regulation of exocytosis GO:0048589 0.009433962264151104 developmental growth Set164a: INO4 ARG80 GCR2 3 GO:0048518 0.0017050710665647084 positive regulation of biological process GO:0048522 0.0024528764648521924 positive regulation of cellular process GO:0009893 0.00316195139558436 positive regulation of metabolic process GO:0031325 0.0036616652222044637 positive regulation of cellular metabolic process GO:0051173 0.008503949852626801 positive regulation of nitrogen compound metabolic process GO:0010604 0.009244052194333488 positive regulation of macromolecule metabolic process Set164b: FBA1 WTM1 2 Set165a: REB1 DAL82 2 Set165b: PET111 PRM1 ERG24 3 GO:0045182 0.005300345062327155 translation regulator activity Set166a: CIN5 REB1 2 Set166b: YKL072W SEC24 YIL108W 3 GO:0030117 0.00944669365722106 membrane coat Set167a: RAP1 SUM1 2 GO:0016458 8.67396076977019E-4 gene silencing GO:0071897 0.005533928707731427 DNA biosynthetic process GO:0006260 0.005533928707731427 DNA replication GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set167b: TNA1 YOR365C RAD2 SCP1 4 GO:0035353 0.0095238095238093 nicotinamide mononucleotide transmembrane transport Set168a: HAP5 ABF1 2 Set168b: EFT2 ATO3 FAS1 3 GO:0005835 0.006578947368420386 fatty acid synthase complex Set169a: ABF1 CIN5 2 Set169b: MSN1 FAS1 HXK2 3 GO:0005835 0.006578947368420386 fatty acid synthase complex GO:0035956 0.006849315068493371 regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter GO:2000906 0.008333333333333401 positive regulation of starch metabolic process Set170a: YAP6 RCS1 PHO2 3 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set170b: HSP78 SEN1 HSP30 3 GO:0044270 0.004677698365550104 cellular nitrogen compound catabolic process GO:0051787 0.005494505494505476 misfolded protein binding GO:0034655 0.006943971610563111 nucleobase-containing compound catabolic process GO:0043335 0.00719424460431706 protein unfolding GO:0046483 0.007327722685779042 heterocycle metabolic process GO:0035649 0.008097165991902366 Nrd1 complex Set171a: YAP6 MET31 2 GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0001010 0.008566533409480154 sequence-specific DNA binding transcription factor recruiting transcription factor activity Set171b: MDM31 RPS14B EGD2 SOP4 4 GO:0005854 0.006024096385541824 nascent polypeptide-associated complex Set172a: STP1 PHO2 GAT1 SUT1 4 GO:0001071 6.020583084831739E-5 nucleic acid binding transcription factor activity GO:0048518 2.0104118072084663E-4 positive regulation of biological process GO:0048522 3.2655912895425713E-4 positive regulation of cellular process GO:0009893 4.5765085988733206E-4 positive regulation of metabolic process GO:0031325 5.56609914430763E-4 positive regulation of cellular metabolic process GO:0051173 0.0017103808914118003 positive regulation of nitrogen compound metabolic process GO:0010604 0.0019142550561718134 positive regulation of macromolecule metabolic process GO:0009891 0.002519625238377181 positive regulation of biosynthetic process GO:0031328 0.002790657755469802 positive regulation of cellular biosynthetic process GO:0045935 0.003247105670396677 positive regulation of nucleobase-containing compound metabolic process GO:0010628 0.0050883905597982095 positive regulation of gene expression GO:0010557 0.00838050437132659 positive regulation of macromolecule biosynthetic process Set172b: GPI14 YJR011C 2 GO:0042157 0.0054446460980044275 lipoprotein metabolic process GO:0042158 0.008264462809917456 lipoprotein biosynthetic process Set173a: SWI4 GCR2 2 Set173b: PDC1 YPS3 YLR125W 3 GO:0042430 0.005725190839695783 indole-containing compound metabolic process GO:0019439 0.009433962264150551 aromatic compound catabolic process Set174a: DAL82 SUM1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set174b: DAL4 DAL1 YDR042C 3 GO:0043603 1.544333399519288E-4 cellular amide metabolic process GO:0000255 3.6062026685894556E-4 allantoin metabolic process GO:0006725 7.935985144339558E-4 cellular aromatic compound metabolic process GO:0000256 0.0021039343572479994 allantoin catabolic process GO:0043605 0.003155901535872003 cellular amide catabolic process GO:0009112 0.008152173913043168 nucleobase metabolic process GO:0050897 0.008333333333333401 cobalt ion binding Set175a: UME6 GCR2 2 GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0034389 0.004184100418409662 lipid particle organization Set175b: MET3 TDH2 GNP1 SMT3 4 GO:0031386 0.0070639969327868065 protein tag GO:0071944 0.009353969292453596 cell periphery Set176a: STP1 MSN2 RDS1 SIP4 4 GO:0001071 6.020583084831739E-5 nucleic acid binding transcription factor activity GO:0048518 0.006217160724096565 positive regulation of biological process GO:0043167 0.007617936484028601 ion binding GO:0048522 0.008831828472544836 positive regulation of cellular process Set176b: TRM13 MDH2 2 Set177a: YAP7 HAP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set177b: PDR16 SOD1 ERG11 ERG11-A ADO1 COX15 6 GO:0051091 0.008064516129032091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0032451 0.008695652173911599 demethylase activity Set178a: CIN5 SKN7 YAP1 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0009628 0.0034995145490484252 response to abiotic stimulus Set178b: CYT2 TCB2 SRX1 3 Set179a: NRG1 SWI4 SWI6 RLM1 4 GO:0007154 0.004142084381604722 cell communication GO:0005667 0.005628517823639318 transcription factor complex GO:0048518 0.006217160724096565 positive regulation of biological process GO:0000988 0.008447845205531702 protein binding transcription factor activity GO:0048522 0.008831828472544836 positive regulation of cellular process Set179b: IRC22 MNN1 CWP1 YKL096C-B 4 GO:0044425 0.005552733281831514 membrane part Set180a: ADR1 PHO2 HAP2 MOT3 RTG3 GLN3 6 GO:0048518 2.73947881644177E-6 positive regulation of biological process GO:0048522 5.675202418751698E-6 positive regulation of cellular process GO:0009893 9.384474617933568E-6 positive regulation of metabolic process GO:0031325 1.2591907193990555E-5 positive regulation of cellular metabolic process GO:0001071 2.888224294143498E-5 nucleic acid binding transcription factor activity GO:0051173 6.76421821462701E-5 positive regulation of nitrogen compound metabolic process GO:0010604 8.042075270943565E-5 positive regulation of macromolecule metabolic process GO:0009891 1.2140738082091765E-4 positive regulation of biosynthetic process GO:0031328 1.4155737295883322E-4 positive regulation of cellular biosynthetic process GO:0045935 1.7728688514961086E-4 positive regulation of nucleobase-containing compound metabolic process GO:0010628 3.4762408451008E-4 positive regulation of gene expression GO:0010557 7.384931316661293E-4 positive regulation of macromolecule biosynthetic process GO:0050789 0.0010985320947536645 regulation of biological process GO:0031323 0.0013129300734310142 regulation of cellular metabolic process GO:0050794 0.0016475372960281444 regulation of cellular process GO:0051716 0.0016968463783931375 cellular response to stimulus GO:0051254 0.0017019573741452268 positive regulation of RNA metabolic process GO:0019222 0.0017315787300720689 regulation of metabolic process GO:0080090 0.001884442490912388 regulation of primary metabolic process GO:0065007 0.002058569125659108 biological regulation GO:0001067 0.0025289094976635156 regulatory region nucleic acid binding GO:0032774 0.0034022992056635627 RNA biosynthetic process GO:0050896 0.0037000260635312913 response to stimulus GO:0051171 0.0038131362710791396 regulation of nitrogen compound metabolic process GO:0009889 0.004395450539561947 regulation of biosynthetic process GO:0033993 0.005026300409117552 response to lipid GO:0060255 0.005673982302805024 regulation of macromolecule metabolic process GO:0031326 0.0060816078543365 regulation of cellular biosynthetic process GO:0003676 0.0065182371316626075 nucleic acid binding GO:0019216 0.007680921390885876 regulation of lipid metabolic process GO:0019219 0.00965476391188814 regulation of nucleobase-containing compound metabolic process GO:0045893 0.00981333180792696 positive regulation of transcription, DNA-dependent Set180b: DPS1 BPT1 2 Set181a: YAP7 ABF1 2 Set181b: RPN4 RPN10 AIM46 VID27 RRG9 5 GO:0044265 0.0063254908695433345 cellular macromolecule catabolic process GO:0009057 0.00756651100261806 macromolecule catabolic process Set182a: RPN4 AFT2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set182b: YJR005C-A POL31 BMH1 PIM1 4 GO:0051219 0.005494505494505476 phosphoprotein binding GO:0042575 0.00606059365571654 DNA polymerase complex GO:0051439 0.008196721311475488 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051716 0.008384515738521489 cellular response to stimulus GO:0070361 0.00925925925925929 mitochondrial light strand promoter anti-sense binding Set183a: SWI5 ABF1 2 Set183b: ENO1 UTP5 PUP2 NCB2 4 GO:0019773 0.008076697928220727 proteasome core complex, alpha-subunit complex GO:0032991 0.009594114428454424 macromolecular complex Set184a: PHO2 MCM1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0051098 0.008708236010966378 regulation of binding GO:0051099 0.008875700626444542 positive regulation of binding Set184b: SIM1 HSP150 YJL160C GPA1 4 GO:0005576 1.0654814081670789E-4 extracellular region GO:0030312 1.683603563742015E-4 external encapsulating structure GO:0071944 3.5411627246733854E-4 cell periphery GO:0030808 0.0035211267605635955 regulation of nucleotide biosynthetic process GO:0005834 0.004048582995951182 heterotrimeric G-protein complex GO:0031234 0.004056795131844034 extrinsic to internal side of plasma membrane GO:0009975 0.004347826086957027 cyclase activity GO:0005199 0.004516711833784948 structural constituent of cell wall GO:0005102 0.005494505494505476 receptor binding GO:0032403 0.005494505494505476 protein complex binding GO:0030810 0.006493506493506457 positive regulation of nucleotide biosynthetic process GO:0045981 0.008658008658008169 positive regulation of nucleotide metabolic process Set185a: RLM1 SOK2 SUT1 3 Set185b: RHO3 RCK1 POG1 RPI1 4 GO:0023052 9.076890244909972E-4 signaling GO:0007154 0.004142084381604722 cell communication GO:0045921 0.006896551724137712 positive regulation of exocytosis Set186a: HSF1 ABF1 2 GO:0030474 0.004608294930875325 spindle pole body duplication Set186b: RPN4 HSP10 YOR020W-A FES1 STI1 5 GO:0060590 0.005126452494873476 ATPase regulator activity Set187a: FHL1 UME6 2 GO:0034389 0.004184100418409662 lipid particle organization GO:0032545 0.006079027355622685 CURI complex GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set187b: BDF1 RPS26B YER130C GDS1 MSC6 5 GO:0009301 0.004672897196261788 snRNA transcription Set188a: ADR1 UME6 2 GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0044255 0.003661258837925632 cellular lipid metabolic process GO:0006629 0.006809315521930216 lipid metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0034389 0.008368200836818863 lipid particle organization Set188b: PPT2 ATP7 PUT3 PXA1 4 GO:0045265 0.00378071833648453 proton-transporting ATP synthase, stator stalk GO:0033240 0.0098522167487688 positive regulation of cellular amine metabolic process Set189a: FKH1 MSN4 MET4 NDD1 4 GO:0048518 2.0104118072084663E-4 positive regulation of biological process GO:0048522 3.2655912895425713E-4 positive regulation of cellular process GO:0009893 4.5765085988733206E-4 positive regulation of metabolic process GO:0031325 5.56609914430763E-4 positive regulation of cellular metabolic process GO:0000117 6.13833544802931E-4 regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0051173 0.0017103808914118003 positive regulation of nitrogen compound metabolic process GO:0010604 0.0019142550561718134 positive regulation of macromolecule metabolic process GO:0009891 0.002519625238377181 positive regulation of biosynthetic process GO:0001071 0.0025913081073285975 nucleic acid binding transcription factor activity GO:0031328 0.002790657755469802 positive regulation of cellular biosynthetic process GO:0045935 0.003247105670396677 positive regulation of nucleobase-containing compound metabolic process GO:0090282 0.00423634336677817 positive regulation of transcription involved in G2/M-phase of mitotic cell cycle GO:0010628 0.0050883905597982095 positive regulation of gene expression GO:0010557 0.00838050437132659 positive regulation of macromolecule biosynthetic process GO:0000988 0.008447845205531702 protein binding transcription factor activity Set189b: GSH1 LSB6 2 GO:0043043 0.003944773175541578 peptide biosynthetic process Set190a: CIN5 SPT2 2 Set190b: YAL037C-A YAL037W SUN4 3 Set191a: MSN2 SOK2 FKH2 3 GO:0001071 6.929813999683202E-4 nucleic acid binding transcription factor activity GO:0016049 0.0022220175034543205 cell growth GO:0040007 0.004529765547119604 growth Set191b: YAP6 CLN1 2 Set192a: SWI4 SWI6 ASH1 MSN4 4 GO:0048518 2.0104118072084663E-4 positive regulation of biological process GO:0048522 3.2655912895425713E-4 positive regulation of cellular process GO:0009893 4.5765085988733206E-4 positive regulation of metabolic process GO:0031325 5.56609914430763E-4 positive regulation of cellular metabolic process GO:0051173 0.0017103808914118003 positive regulation of nitrogen compound metabolic process GO:0010604 0.0019142550561718134 positive regulation of macromolecule metabolic process GO:0009891 0.002519625238377181 positive regulation of biosynthetic process GO:0001071 0.0025913081073285975 nucleic acid binding transcription factor activity GO:0031328 0.002790657755469802 positive regulation of cellular biosynthetic process GO:0045935 0.003247105670396677 positive regulation of nucleobase-containing compound metabolic process GO:0010628 0.0050883905597982095 positive regulation of gene expression GO:0000082 0.00630252100840354 G1/S transition of mitotic cell cycle GO:0045596 0.006849315068493371 negative regulation of cell differentiation GO:0010557 0.00838050437132659 positive regulation of macromolecule biosynthetic process Set192b: YOL114C SKM1 2 Set193a: SWI5 MSN2 MCM1 3 Set193b: PIL1 YGP1 2 GO:0032126 0.007518796992481911 eisosome Set194a: DIG1 INO2 2 Set194b: STB3 STB3-A 2 Set195a: STP1 DAL82 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set195b: REC104 LIN1 2 Set196a: STE12 HAC1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0000003 0.009381626409405661 reproduction Set196b: SIL1 GAS5 2 Set197a: YAP7 STE12 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set197b: KTR2 WSC3 2 Set198a: HSF1 STE12 2 GO:0030474 0.004608294930875325 spindle pole body duplication GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set198b: CPR6 YDL180W 2 Set199a: IME1 RAP1 2 Set199b: MUP3 CBP2 2 GO:0072348 0.008163265306123324 sulfur compound transport Set200a: UME6 GTS1 2 GO:0045017 8.058017727639538E-4 glycerolipid biosynthetic process GO:0019637 0.0010752657584745687 organophosphate metabolic process GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0048511 0.0017683465959339032 rhythmic process GO:0008654 0.0019415985572312402 phospholipid biosynthetic process GO:0044255 0.003661258837925632 cellular lipid metabolic process GO:0034389 0.004184100418409662 lipid particle organization GO:0006629 0.006809315521930216 lipid metabolic process GO:0008610 0.009269356597604242 lipid biosynthetic process Set200b: YPK9 SNF2 2 Set201a: UME6 PUT3 2 GO:0034389 0.004184100418409662 lipid particle organization GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set201b: KIP1 PRX1 2 GO:0006276 0.003990021954094283 plasmid maintenance Set202a: RPN4 GTS1 2 GO:0048511 0.0017683465959339032 rhythmic process GO:0031329 0.004379054680260413 regulation of cellular catabolic process GO:0009894 0.004749599092979486 regulation of catabolic process GO:0048583 0.007084194084749055 regulation of response to stimulus Set202b: CHD1 YER163C 2 GO:0001173 0.004629629629629636 DNA-dependent transcriptional start site selection Set203a: HAP4 FKH2 2 GO:0000988 0.0014804034334107972 protein binding transcription factor activity GO:0005667 0.005628517823639318 transcription factor complex GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set203b: KGD2 NUM1 2 GO:0045252 0.004042442576846418 oxoglutarate dehydrogenase complex Set204a: PHO4 FKH2 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set204b: PBY1 PHO5 2 GO:0042597 0.005529944496119855 periplasmic space GO:0035770 0.006097560975608535 ribonucleoprotein granule Set205a: HSF1 RAP1 2 GO:0030474 0.004608294930875325 spindle pole body duplication GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set205b: HSP12 MDJ1 2 GO:0022610 0.0035351282833773565 biological adhesion GO:0007155 0.003990021954094283 cell adhesion GO:0009408 0.008255933952527736 response to heat Set206a: ABF1 CHA4 2 Set206b: RPC25 LTV1 2 Set207a: GAL4 GAL80 2 GO:0044262 0.007859271080281276 cellular carbohydrate metabolic process GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set207b: GAL1 GAL10 2 GO:0044262 0.007859271080281276 cellular carbohydrate metabolic process GO:0019388 0.009999999999999995 galactose catabolic process Set208a: MET4 XBP1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set208b: SAM1 YLR179C 2 Set209a: HAP5 MCM1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set209b: GYP8 STE2 2 GO:0005549 0.0014925373134327406 odorant binding GO:0023052 0.00388879760256425 signaling Set210a: MBP1 ARR1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set210b: POL2 YIF1 2 GO:0042575 0.004042442576846418 DNA polymerase complex Set211a: ABF1 SUM1 2 GO:0016458 8.67396076977019E-4 gene silencing GO:0003688 0.004691898654988847 DNA replication origin binding GO:0071897 0.005533928707731427 DNA biosynthetic process GO:0006260 0.005533928707731427 DNA replication Set211b: SPR3 PMT2 2 GO:0031501 0.002022244691608034 mannosyltransferase complex GO:0031502 0.003333333333333215 dolichyl-phosphate-mannose-protein mannosyltransferase complex GO:0042763 0.009208056069478677 intracellular immature spore Set212a: ABF1 BAS1 2 Set212b: SIZ1 ADE8 2 Set213a: ABF1 XBP1 2 Set213b: OCA5 WSC4 2 GO:0023052 0.00388879760256425 signaling Set214a: SWI5 ADR1 2 Set214b: YDL119C CYK3 2 GO:0070938 0.007369852091871375 contractile ring Set215a: RME1 BAS1 2 GO:0022414 0.006267458510370168 reproductive process GO:0048610 0.007986025950098693 cellular process involved in reproduction GO:0000003 0.009381626409405661 reproduction Set215b: ADE5,7 MTO1 2 GO:0000959 0.0033898305084744005 mitochondrial RNA metabolic process GO:0000963 0.00787401574803151 mitochondrial RNA processing Set216a: CBF1 ASH1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity GO:0090153 0.008264462809916032 regulation of sphingolipid biosynthetic process Set216b: PST1 CDC34 2 GO:0000151 0.008088978766430744 ubiquitin ligase complex Set217a: DAL82 SUT1 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set217b: ACA1 SPO73 2 Set218a: CST6 DAL82 2 GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set218b: DOS2 OCA6 2 Set219a: REB1 LEU3 2 GO:2000284 0.0061349693251533475 positive regulation of cellular amino acid biosynthetic process GO:2000282 0.007246376811594155 regulation of cellular amino acid biosynthetic process GO:0033240 0.0098522167487688 positive regulation of cellular amine metabolic process Set219b: FSF1 YTM1 2 GO:0070545 0.0035842293906811636 PeBoW complex Set220a: SPT23 REB1 2 Set220b: snR37 NIC96 2 GO:0055125 0.007319286218371828 Nic96 complex GO:0046930 0.008421052631579308 pore complex Set221a: REB1 SNT2 2 Set221b: SUP45 ADH5 2 GO:0018444 0.0015060240963856216 translation release factor complex Set222a: HSF1 SKN7 2 GO:0023052 0.00388879760256425 signaling GO:0030474 0.004608294930875325 spindle pole body duplication GO:0001071 0.007902787884486728 nucleic acid binding transcription factor activity Set222b: YGR210C ZPR1 2 Set223a: RCS1 ZAP1 2 Set223b: LST4 ZRT3 2 GO:0005215 0.006550706947418225 transporter activity Set224a: YAP7 SPT23 2 Set224b: PET18-A ASI1 2 Set225a: SPT23 CST6 2 Set225b: RLP7 DOM34 2 GO:0043021 0.008941837895726123 ribonucleoprotein complex binding Set226a: CIN5 RIM101 2 GO:0071454 0.008333333333333401 cellular response to anoxia Set226b: YTA12 YMR090W 2 GO:0006465 0.0035211267605635955 signal peptide processing GO:0005745 0.004032258064516497 m-AAA complex GO:0006518 0.008760951188986421 peptide metabolic process ============================= E. coli ============================= Set1a: narL fnr 2 Set1b: frdC dmsB fdnG fdnH fdnI narJ napG napF napD napC napB nirC nirB narG nrfA napH nrfF frdA frdB nrfE nrfB nrfC fumB frdD adhE cydC dsbE dmsC napA narH cysG dmsA nrfG dcuB caiF pflB ccmH ccmE focA ccmD ccmF ccmA ccmC ccmB narI narK nirD cydD nuoB nuoC nuoA nuoF nuoG nuoE nuoJ nuoK nuoH nuoI nuoN nrfD nuoL nuoM 62 GO:0006091 1.3890309595568414E-18 generation of precursor metabolites and energy GO:0055114 1.1153803005348359E-12 oxidation-reduction process GO:0009055 1.581818058554696E-9 electron carrier activity GO:0042126 3.917550898048976E-9 nitrate metabolic process GO:0071841 8.913666760766184E-9 cellular component organization or biogenesis at cellular level GO:0016020 9.891684513923126E-9 membrane GO:0044425 1.4432982937327978E-8 membrane part GO:0071941 3.328153632594104E-8 nitrogen cycle metabolic process GO:0071944 1.2428287022586656E-7 cell periphery GO:0051540 1.4606910418880832E-7 metal cluster binding GO:0030964 1.7876346602398363E-7 NADH dehydrogenase complex GO:0072521 3.5521200101477953E-7 purine-containing compound metabolic process GO:0018130 9.341243374117265E-7 heterocycle biosynthetic process GO:0016491 1.5617322382982838E-6 oxidoreductase activity GO:0045272 3.7078235076010005E-6 plasma membrane respiratory chain complex I GO:0071840 9.854207154887622E-6 cellular component organization or biogenesis GO:0055086 1.2789012197095785E-5 nucleobase-containing small molecule metabolic process GO:0048038 1.8378728004428645E-5 quinone binding GO:0032991 2.0339314792346916E-5 macromolecular complex GO:0070470 2.7157301907023603E-5 plasma membrane respiratory chain GO:0070469 2.9296341840565293E-5 respiratory chain GO:0022900 3.612922567258378E-5 electron transport chain GO:0034621 4.624155613177165E-5 cellular macromolecular complex subunit organization GO:0051184 7.047195656578501E-5 cofactor transporter activity GO:0015980 7.523408626030445E-5 energy derivation by oxidation of organic compounds GO:0051181 8.46833578792323E-5 cofactor transport GO:0016661 1.480140389495264E-4 oxidoreductase activity, acting on other nitrogenous compounds as donors GO:0016651 1.5701494957002805E-4 oxidoreductase activity, acting on NADH or NADPH GO:0043412 1.6154603310566205E-4 macromolecule modification GO:0071842 1.7117825929785095E-4 cellular component organization at cellular level GO:0043167 3.2847460651964797E-4 ion binding GO:0071844 3.442978971343797E-4 cellular component assembly at cellular level GO:0044267 3.7488340240632843E-4 cellular protein metabolic process GO:0034654 4.678842962364395E-4 nucleobase-containing compound biosynthetic process GO:0043623 6.240898689411239E-4 cellular protein complex assembly GO:0034622 6.601113704607758E-4 cellular macromolecular complex assembly GO:0009061 6.622033275364048E-4 anaerobic respiration GO:0044085 0.00233253891790478 cellular component biogenesis GO:0022607 0.00233253891790478 cellular component assembly GO:0044271 0.003056746351684993 cellular nitrogen compound biosynthetic process GO:0048037 0.003064015421424699 cofactor binding GO:0072522 0.004638066427639252 purine-containing compound biosynthetic process GO:0017006 0.00476190476190475 protein-tetrapyrrole linkage GO:0046148 0.005049938278532471 pigment biosynthetic process GO:0044459 0.005956215176093405 plasma membrane part GO:0009325 0.0065449677296732685 nitrate reductase complex GO:0009326 0.0065449677296732685 formate dehydrogenase complex GO:0009390 0.0065449677296732685 dimethyl sulfoxide reductase complex GO:0051179 0.006596356484948211 localization GO:0015985 0.0068390122556587375 energy coupled proton transport, down electrochemical gradient GO:0046906 0.008407041338358212 tetrapyrrole binding GO:0045271 0.009523809523809518 respiratory chain complex I GO:0010181 0.009702047903861786 FMN binding Set2a: crp tdcA fnr tdcR lysR ihf 6 GO:0048518 3.17730373585894E-5 positive regulation of biological process GO:0009893 4.166885469487344E-5 positive regulation of metabolic process GO:0050789 8.733439259513272E-4 regulation of biological process GO:0065007 0.0010308417562803138 biological regulation GO:0050794 0.0012012926745587822 regulation of cellular process GO:0048522 0.0012818823683404448 positive regulation of cellular process GO:0031325 0.001720860275246586 positive regulation of cellular metabolic process GO:0019222 0.0017812412106296607 regulation of metabolic process GO:0010604 0.0022079746850388426 positive regulation of macromolecule metabolic process GO:0031323 0.0023855279504719834 regulation of cellular metabolic process GO:0001071 0.00349447298880823 nucleic acid binding transcription factor activity GO:0010628 0.0035994493343563323 positive regulation of gene expression GO:0003676 0.003949327412825694 nucleic acid binding GO:0051173 0.005770420649471464 positive regulation of nitrogen compound metabolic process GO:0043170 0.006408745635154252 macromolecule metabolic process GO:0080090 0.006826616083115876 regulation of primary metabolic process GO:0044260 0.007635402546158497 cellular macromolecule metabolic process Set2b: tdcE tdcD tdcG tdcF tdcA tdcC tdcB 7 GO:0009310 8.798951706430264E-7 amine catabolic process GO:0016054 5.457802727451859E-5 organic acid catabolic process GO:0006520 7.831618755794868E-5 cellular amino acid metabolic process GO:0009063 8.141584645827164E-5 cellular amino acid catabolic process GO:0044248 1.3025010422166626E-4 cellular catabolic process GO:0006082 2.4111236877833746E-4 organic acid metabolic process GO:0042180 2.4111236877833746E-4 cellular ketone metabolic process GO:0009066 3.1496409849785624E-4 aspartate family amino acid metabolic process GO:0009068 3.7526972511492564E-4 aspartate family amino acid catabolic process GO:0009308 4.65864864249824E-4 amine metabolic process GO:0044106 7.218570534050286E-4 cellular amine metabolic process GO:0009056 7.805315172059334E-4 catabolic process GO:0044282 0.0013168961326228271 small molecule catabolic process GO:0006566 0.0013986013986014001 threonine metabolic process GO:0046395 0.0018945984952736766 carboxylic acid catabolic process Set3a: ihf arcA 2 Set3b: glcE aceK nuoB aceB aceA pflB glcB nuoA nuoG gltA sodA focA glcF glcG sucA nuoC sucC sucB nuoF sucD nuoE nuoJ nuoK nuoH nuoI nuoN glcD nuoL nuoM 29 GO:0030964 1.9282774894819376E-15 NADH dehydrogenase complex GO:0055114 3.861406427376517E-14 oxidation-reduction process GO:0070469 9.053038575408473E-14 respiratory chain GO:0006091 9.61487379161072E-12 generation of precursor metabolites and energy GO:0048037 3.6699691529972195E-10 cofactor binding GO:0044459 8.931822949052804E-10 plasma membrane part GO:0045272 6.058535143138922E-9 plasma membrane respiratory chain complex I GO:0070470 5.2889374357672154E-8 plasma membrane respiratory chain GO:0018130 5.378611551062727E-7 heterocycle biosynthetic process GO:0034654 7.498789179884722E-7 nucleobase-containing compound biosynthetic process GO:0016651 1.1297262106061528E-6 oxidoreductase activity, acting on NADH or NADPH GO:0003824 1.1900985842914604E-6 catalytic activity GO:0005887 9.48804815325573E-6 integral to plasma membrane GO:0072522 1.6641041144218273E-5 purine-containing compound biosynthetic process GO:0051186 2.013362314958891E-5 cofactor metabolic process GO:0048038 5.833285146243289E-5 quinone binding GO:0032991 8.542659760519611E-5 macromolecular complex GO:0032787 9.139848826900534E-5 monocarboxylic acid metabolic process GO:0009142 9.269558769002668E-5 nucleoside triphosphate biosynthetic process GO:0072521 1.1813353832472344E-4 purine-containing compound metabolic process GO:0051187 1.3844572461572978E-4 cofactor catabolic process GO:0009201 1.7683465959328112E-4 ribonucleoside triphosphate biosynthetic process GO:0009145 2.229654403567443E-4 purine nucleoside triphosphate biosynthetic process GO:0009206 2.837741968176731E-4 purine ribonucleoside triphosphate biosynthetic process GO:0016746 4.072149265015435E-4 transferase activity, transferring acyl groups GO:0016491 4.6764974864285777E-4 oxidoreductase activity GO:0006081 5.642906194434971E-4 cellular aldehyde metabolic process GO:0006097 7.152639357821853E-4 glyoxylate cycle GO:0015985 7.164655885456755E-4 energy coupled proton transport, down electrochemical gradient GO:0009152 7.78072502210437E-4 purine ribonucleotide biosynthetic process GO:0006754 8.321198252548355E-4 ATP biosynthetic process GO:0042773 8.741258741258758E-4 ATP synthesis coupled electron transport GO:0006164 0.0010196514645902936 purine nucleotide biosynthetic process GO:0006818 0.0011225657784396153 hydrogen transport GO:0046296 0.0011853959222380365 glycolate catabolic process GO:0019154 0.0012254901960784348 glycolate dehydrogenase activity GO:0009060 0.0012998537262745775 aerobic respiration GO:0044271 0.001532138864676694 cellular nitrogen compound biosynthetic process GO:0009260 0.0018936384342391156 ribonucleotide biosynthetic process GO:0044248 0.002469352497573686 cellular catabolic process GO:0009165 0.0049335863377608855 nucleotide biosynthetic process GO:0006119 0.006092782413750003 oxidative phosphorylation GO:0031226 0.006839309994085009 intrinsic to plasma membrane GO:0015988 0.007786429365962115 energy coupled proton transport, against electrochemical gradient GO:0034220 0.00880298805179008 ion transmembrane transport GO:0006811 0.008860343378837291 ion transport GO:0045271 0.009523809523809518 respiratory chain complex I GO:0010181 0.009702047903861786 FMN binding Set4a: crp arcA fnr 3 GO:0001071 0.004876185916344395 nucleic acid binding transcription factor activity GO:0050896 0.007998558818231808 response to stimulus GO:0048522 0.008180402887200563 positive regulation of cellular process GO:0048518 0.008252246294016772 positive regulation of biological process GO:0009893 0.009552234343364968 positive regulation of metabolic process GO:0048519 0.009994990412687461 negative regulation of biological process GO:0031325 0.009999398680376822 positive regulation of cellular metabolic process Set4b: b0725 pflB acnA sucA sucC sucB glpA sucD glpC glpB sdhA focA sdhC sdhB sdhD 15 GO:0051186 1.8849963542330892E-8 cofactor metabolic process GO:0055114 6.78698100969796E-7 oxidation-reduction process GO:0051187 9.86605839128013E-7 cofactor catabolic process GO:0009056 4.405530356007278E-6 catabolic process GO:0006091 4.5572471319892194E-6 generation of precursor metabolites and energy GO:0044248 3.9152860817119E-4 cellular catabolic process GO:0045281 0.0023252864330105256 succinate dehydrogenase complex GO:0045273 0.0023252864330105256 respiratory chain complex II GO:0016627 0.0033429284216211605 oxidoreductase activity, acting on the CH-CH group of donors GO:0003824 0.0034249101722867927 catalytic activity GO:0005975 0.004217465565754586 carbohydrate metabolic process GO:0006099 0.004854715499393122 tricarboxylic acid cycle GO:0009060 0.006957599325728192 aerobic respiration GO:0048037 0.007999418397374924 cofactor binding GO:0019405 0.0082065871539556 alditol catabolic process Set5a: lrp ihf 2 Set5b: yeiL ilvD fimH ilvL ilvg_1 ompC ilvM fimA ompF fimC fimD fimF fimG ilvE fimI ilvg_2 ilvA 17 GO:0042995 2.955883333437908E-7 cell projection GO:0007155 1.249306198238839E-6 cell adhesion GO:0022610 8.527145904326135E-6 biological adhesion GO:0009081 2.180520681908238E-4 branched chain family amino acid metabolic process GO:0044283 5.430079784040772E-4 small molecule biosynthetic process GO:0016053 7.100912966485025E-4 organic acid biosynthetic process GO:0030313 0.001408796105461485 cell envelope GO:0006520 0.001978789005630832 cellular amino acid metabolic process GO:0022803 0.0020202020202020362 passive transmembrane transporter activity GO:0019867 0.0023059827562315455 outer membrane GO:0009082 0.0038903625110521993 branched chain family amino acid biosynthetic process GO:0006082 0.004753872226211701 organic acid metabolic process GO:0042180 0.004753872226211701 cellular ketone metabolic process GO:0046930 0.0051755452074996235 pore complex GO:0044271 0.005396777557738892 cellular nitrogen compound biosynthetic process GO:0009058 0.006881017068016079 biosynthetic process GO:0044462 0.007157752948599116 external encapsulating structure part GO:0009308 0.00810604863794694 amine metabolic process GO:0030312 0.008256227373284988 external encapsulating structure Set6a: fhlA ihf modE 3 Set6b: hycD hycE hycF hycG hycA hycB hycC hycH 8 GO:0009375 3.854264838164111E-10 ferredoxin hydrogenase complex GO:0032991 1.4180343368238904E-4 macromolecular complex GO:0051540 3.7074509347302464E-4 metal cluster binding GO:0044424 0.004157609748849111 intracellular part Set7a: soxS rob marA 3 GO:0001071 0.004876185916344395 nucleic acid binding transcription factor activity Set7b: marA marB nfo zwf fumC marR sodA 7 GO:0050896 3.3922373989027875E-4 response to stimulus GO:0042221 0.0026902557919511213 response to chemical stimulus Set8a: crp gutR gutM 3 Set8b: srlB srlA srlE srlD gutQ srlR gutM 7 GO:0009401 0.0020797882397428926 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0046400 0.009803921568627428 keto-3-deoxy-D-manno-octulosonic acid metabolic process Set9a: fis crp 2 Set9b: hupA aldB hupB guaB guaA mtlR acnB lpdA sdhC proP sucA sucC sucB sucD b0725 sdhA mtlA sdhB sdhD mtlD 20 GO:0051186 1.198139022251313E-7 cofactor metabolic process GO:0051187 9.86605839128013E-7 cofactor catabolic process GO:0009060 0.0011132158921165326 aerobic respiration GO:0044248 0.0018131642225209343 cellular catabolic process GO:0055114 0.002233882005611911 oxidation-reduction process GO:0009126 0.0022988505747126415 purine nucleoside monophosphate metabolic process GO:0045281 0.0023252864330105256 succinate dehydrogenase complex GO:0045273 0.0023252864330105256 respiratory chain complex II GO:0009167 0.0024630541871921248 purine ribonucleoside monophosphate metabolic process GO:0006091 0.0025973029847457846 generation of precursor metabolites and energy GO:0016627 0.0033429284216211605 oxidoreductase activity, acting on the CH-CH group of donors GO:0006099 0.004854715499393122 tricarboxylic acid cycle GO:0016874 0.008653864376936132 ligase activity GO:0005515 0.009860886731731298 protein binding Set10a: deoR cytR crp 3 GO:0048519 1.9001882913854495E-4 negative regulation of biological process GO:0048523 2.2205730247123345E-4 negative regulation of cellular process GO:0009892 2.84044797922406E-4 negative regulation of metabolic process GO:0031324 3.674479771021995E-4 negative regulation of cellular metabolic process GO:0051172 0.0015683111529327964 negative regulation of nitrogen compound metabolic process GO:0009890 0.003392130257802081 negative regulation of biosynthetic process GO:0031327 0.0034698126301181322 negative regulation of cellular biosynthetic process GO:0045934 0.004185680566482822 negative regulation of nucleobase-containing compound metabolic process GO:0001071 0.004876185916344395 nucleic acid binding transcription factor activity GO:0010605 0.005835380835380669 negative regulation of macromolecule metabolic process GO:2000113 0.009608785175016992 negative regulation of cellular macromolecule biosynthetic process GO:0010558 0.009608785175016992 negative regulation of macromolecule biosynthetic process Set10b: nupG tsx deoA deoB deoC deoD 6 GO:0015931 2.020202020202025E-4 nucleobase-containing compound transport GO:0055086 7.921984198852672E-4 nucleobase-containing small molecule metabolic process GO:0016757 8.503401360544278E-4 transferase activity, transferring glycosyl groups GO:0015932 8.865248226950288E-4 nucleobase-containing compound transmembrane transporter activity GO:0051716 0.005466785669396876 cellular response to stimulus GO:0043094 0.0075187969924814975 cellular metabolic compound salvage GO:0046483 0.008439213127326383 heterocycle metabolic process Set11a: caiF crp ihf 3 Set11b: caiT caiE caiD caiC caiB caiA 6 GO:0006577 1.0639101464048194E-8 betaine metabolic process GO:0009437 4.405092286683309E-7 carnitine metabolic process GO:0006520 7.831618755794868E-5 cellular amino acid metabolic process GO:0006082 2.4111236877833746E-4 organic acid metabolic process GO:0042180 2.4111236877833746E-4 cellular ketone metabolic process GO:0009308 4.65864864249824E-4 amine metabolic process GO:0044106 7.218570534050286E-4 cellular amine metabolic process Set12a: araC crp 2 Set12b: arah_1 araB araC araA araF araG araD araE araJ arah_2 10 GO:0019637 1.4650396052277523E-4 organophosphate metabolic process GO:0009056 7.805315172059334E-4 catabolic process GO:0019321 0.004996593231887357 pentose metabolic process GO:0051167 0.008791208791208786 xylulose 5-phosphate metabolic process Set13a: crp yiaJ 2 GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process Set13b: yiaQ yiaP yiaS yiaR yiaK yiaM yiaL yiaO yiaN 9 GO:0055085 0.007929236561110635 transmembrane transport Set14a: arcA appY 2 GO:0048522 0.002818458137606834 positive regulation of cellular process GO:0048518 0.0028445242907403287 positive regulation of biological process GO:0009893 0.0033002588438306173 positive regulation of metabolic process GO:0031325 0.0034570411794607836 positive regulation of cellular metabolic process GO:0007154 0.004255319148935838 cell communication GO:0051173 0.007972892166633187 positive regulation of nitrogen compound metabolic process Set14b: hyaB hyaC hyaA hyaF hyaD hyaE appC appB appA 9 GO:0070069 0.0014423076923076618 cytochrome complex GO:0016695 0.0021621621621621514 oxidoreductase activity, acting on hydrogen as donor GO:0016679 0.0021621621621621514 oxidoreductase activity, acting on diphenols and related substances as donors GO:0016730 0.0021621621621621514 oxidoreductase activity, acting on iron-sulfur proteins as donors GO:0019646 0.0038461538461538503 aerobic electron transport chain GO:0006793 0.006606244060300372 phosphorus metabolic process Set15a: fhlA ihf fnr 3 Set15b: hypE hypD hypA hypC hypB 5 GO:0051604 8.246103303883377E-7 protein maturation GO:0019538 9.090634146905581E-7 protein metabolic process GO:0043412 0.004769096512215654 macromolecule modification GO:0043170 0.006408745635154252 macromolecule metabolic process GO:0031234 0.00826446280991744 extrinsic to internal side of plasma membrane GO:0044267 0.00849243739151974 cellular protein metabolic process GO:0016151 0.00853485064011383 nickel cation binding GO:0019898 0.009433962264151104 extrinsic to membrane Set16a: crp nagC 2 Set16b: manX manY manZ nagD nagE nagB nagC nagA 8 GO:0008982 1.7721070352649394E-4 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0006054 3.9123630672926795E-4 N-acetylneuraminate metabolic process GO:0006040 0.0015015015015015039 amino sugar metabolic process GO:0046348 0.004329004329004323 amino sugar catabolic process GO:0009401 0.008111174134997278 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0015761 0.008333333333333312 mannose transport GO:0015578 0.008333333333333312 mannose transmembrane transporter activity GO:0005975 0.009018816680311757 carbohydrate metabolic process Set17a: malT crp 2 GO:0007154 0.004255319148935838 cell communication Set17b: lamB malS malM malK malF malG malE 7 GO:0042946 6.233131587641023E-6 glucoside transport GO:0043190 1.465376706852978E-5 ATP-binding cassette (ABC) transporter complex GO:0015774 3.6578640632735636E-5 polysaccharide transport GO:0033036 4.862850648285528E-5 macromolecule localization GO:0015772 1.2515472108868734E-4 oligosaccharide transport GO:0042947 3.952569169960448E-4 glucoside transmembrane transporter activity GO:0044270 0.0011820330969266703 cellular nitrogen compound catabolic process GO:0016787 0.0013794396557834051 hydrolase activity GO:0051234 0.0020216057380283976 establishment of localization GO:0051179 0.002541757972736369 localization GO:0015157 0.002736726874657923 oligosaccharide transmembrane transporter activity GO:0034655 0.0029066366704161963 nucleobase-containing compound catabolic process GO:0015422 0.0034965034965034974 oligosaccharide-transporting ATPase activity GO:0005215 0.003853232372242969 transporter activity GO:0055085 0.004422710129714908 transmembrane transport GO:0055086 0.004892990240467929 nucleobase-containing small molecule metabolic process GO:0072521 0.005062596638236201 purine-containing compound metabolic process GO:0015154 0.005477131564088054 disaccharide transmembrane transporter activity GO:0033037 0.007575757575757558 polysaccharide localization GO:0046483 0.008439213127326383 heterocycle metabolic process GO:0009056 0.008740783657098768 catabolic process GO:0032991 0.00892641408226042 macromolecular complex Set18a: crp fucR 2 Set18b: fucA fucO fucK fucI fucU fucR fucP 7 GO:0006004 1.2161751292186011E-5 fucose metabolic process GO:0044262 2.7347886651521942E-5 cellular carbohydrate metabolic process GO:0005975 2.3693626773902156E-4 carbohydrate metabolic process GO:0006066 7.304585731235551E-4 alcohol metabolic process GO:0044281 0.0054595459117043246 small molecule metabolic process GO:0005996 0.006318765624603002 monosaccharide metabolic process Set19a: rob crp galR 3 GO:0001071 0.004876185916344395 nucleic acid binding transcription factor activity Set19b: galT galE galM galK 4 GO:0006012 3.344481605351145E-4 galactose metabolic process GO:0019388 7.326007326007312E-4 galactose catabolic process GO:0044262 0.0026626385724160375 cellular carbohydrate metabolic process GO:0009056 0.008740783657098768 catabolic process GO:0005975 0.009018816680311757 carbohydrate metabolic process Set20a: rhasr crp rhaS 3 Set20b: rhaD rhaA rhaT rhaB 4 GO:0019301 0.007142857142857133 rhamnose catabolic process GO:0019299 0.007692307692307674 rhamnose metabolic process Set21a: rcsab rcsB 2 Set21b: rcsA b2060 wzb wcaB wcaA wza 6 GO:0005976 1.1806822078179471E-5 polysaccharide metabolic process GO:0044264 1.443345096595753E-5 cellular polysaccharide metabolic process GO:0000271 1.8066187010031944E-5 polysaccharide biosynthetic process GO:0033692 1.8066187010031944E-5 cellular polysaccharide biosynthetic process GO:0016051 2.2112775762217757E-5 carbohydrate biosynthetic process GO:0034637 2.469238730701487E-5 cellular carbohydrate biosynthetic process GO:0045229 9.380863039399691E-5 external encapsulating structure organization GO:0008610 0.003172558561137792 lipid biosynthetic process GO:0044255 0.003730631021180896 cellular lipid metabolic process GO:0043170 0.006408745635154252 macromolecule metabolic process GO:0044260 0.007635402546158497 cellular macromolecule metabolic process GO:0006629 0.007827812492152399 lipid metabolic process Set22a: csgD ompR 2 GO:0060089 0.0018436254455425963 molecular transducer activity GO:0023052 0.0020360805449509693 signaling GO:0048522 0.002818458137606834 positive regulation of cellular process GO:0048518 0.0028445242907403287 positive regulation of biological process GO:0009893 0.0033002588438306173 positive regulation of metabolic process GO:0031325 0.0034570411794607836 positive regulation of cellular metabolic process GO:0007154 0.004255319148935838 cell communication GO:0051173 0.007972892166633187 positive regulation of nitrogen compound metabolic process Set22b: csgG csgF csgE csgD csgB csgA 6 GO:0022610 2.8067305589309307E-8 biological adhesion GO:0051704 8.77995209606991E-8 multi-organism process GO:0019867 2.1027116551278037E-4 outer membrane GO:0071806 4.0241448692153334E-4 protein transmembrane transport GO:0044462 6.573885935076313E-4 external encapsulating structure part GO:0030312 7.671808143907152E-4 external encapsulating structure GO:0031975 0.001026030218984964 envelope GO:0015031 0.0020202020202020237 protein transport GO:0045184 0.0020202020202020237 establishment of protein localization GO:0007155 0.005537092912019024 cell adhesion GO:0030313 0.0060392577234127725 cell envelope GO:0042995 0.007031411762355153 cell projection Set23a: fruR crp 2 Set23b: crr mtlR pgk ptsI ptsH mtlA epd mtlD 8 GO:0006793 4.0719417701613124E-4 phosphorus metabolic process GO:0019197 8.815750808110286E-4 phosphoenolpyruvate-dependent sugar phosphotransferase complex GO:0006818 0.0022582228767795403 hydrogen transport GO:0009401 0.008111174134997278 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005402 0.00884173297966406 cation:sugar symporter activity Set24a: crp glpR 2 GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process Set24b: glpT glpQ glpD glpF glpA glpC glpB glpK 8 GO:0019400 5.170998009510495E-8 alditol metabolic process GO:0019751 2.0327434311895982E-7 polyol metabolic process GO:0044262 2.7347886651521942E-5 cellular carbohydrate metabolic process GO:0019405 2.0811475919834993E-4 alditol catabolic process GO:0005975 2.3693626773902156E-4 carbohydrate metabolic process GO:0019637 2.53811368058046E-4 organophosphate metabolic process GO:0046174 4.2679626203802877E-4 polyol catabolic process GO:0015850 6.049606775559632E-4 organic alcohol transport GO:0006066 7.304585731235551E-4 alcohol metabolic process GO:0009331 8.815750808110286E-4 glycerol-3-phosphate dehydrogenase complex GO:0015665 8.865248226950288E-4 alcohol transmembrane transporter activity GO:0015793 0.001107419712070876 glycerol transport GO:0016901 0.0012254901960784348 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor GO:0006072 0.002836074872376637 glycerol-3-phosphate metabolic process GO:0044281 0.0054595459117043246 small molecule metabolic process Set25a: lrp leuO 2 Set25b: leuL leuA leuB leuD leuC 5 GO:0044283 1.0319608639353738E-4 small molecule biosynthetic process GO:0016053 1.356915373431495E-4 organic acid biosynthetic process GO:0009081 2.180520681908238E-4 branched chain family amino acid metabolic process GO:0006520 3.950616572367491E-4 cellular amino acid metabolic process GO:0006082 9.932390116838613E-4 organic acid metabolic process GO:0042180 9.932390116838613E-4 cellular ketone metabolic process GO:0044271 0.001128917754424943 cellular nitrogen compound biosynthetic process GO:0009308 0.0017392288265326516 amine metabolic process GO:0044106 0.002502437785137493 cellular amine metabolic process GO:0009082 0.0038903625110521993 branched chain family amino acid biosynthetic process GO:0003861 0.0095238095238095 3-isopropylmalate dehydratase activity Set26a: crp rbsR 2 Set26b: rbsA rbsC rbsB rbsK rbsD 5 GO:0046483 0.002330670026191085 heterocycle metabolic process GO:0019303 0.00854700854700853 D-ribose catabolic process GO:0006014 0.008563899868247642 D-ribose metabolic process Set27a: pspF ihf 2 Set27b: pspE pspD pspC pspB pspA 5 GO:0050896 3.025191949120908E-4 response to stimulus GO:0009607 0.0037023324694557378 response to biotic stimulus GO:0051704 0.009348104131808197 multi-organism process Set28a: lrp gcvA purR 3 GO:0001071 0.004876185916344395 nucleic acid binding transcription factor activity Set28b: gcvP gcvH gcvT 3 GO:0009069 0.0028571428571428532 serine family amino acid metabolic process GO:0006520 0.00954068420335135 cellular amino acid metabolic process Set29a: uidR uxuR 2 Set29b: uidB uidR uidC uidA 4 Set30a: crp ompR 2 GO:0048522 0.002818458137606834 positive regulation of cellular process GO:0048518 0.0028445242907403287 positive regulation of biological process GO:0009893 0.0033002588438306173 positive regulation of metabolic process GO:0031325 0.0034570411794607836 positive regulation of cellular metabolic process GO:0007154 0.004255319148935838 cell communication GO:0051173 0.007972892166633187 positive regulation of nitrogen compound metabolic process Set30b: nmpC flhC flhD fadL 4 GO:0009893 0.0033002588438306173 positive regulation of metabolic process GO:0031325 0.0034570411794607836 positive regulation of cellular metabolic process GO:0019867 0.007724301841948019 outer membrane GO:0051173 0.007972892166633187 positive regulation of nitrogen compound metabolic process GO:0048522 0.008180402887200563 positive regulation of cellular process Set31a: gntR crp 2 GO:0048522 0.002818458137606834 positive regulation of cellular process GO:0048518 0.0028445242907403287 positive regulation of biological process GO:0009893 0.0033002588438306173 positive regulation of metabolic process GO:0031325 0.0034570411794607836 positive regulation of cellular metabolic process GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process GO:0051173 0.007972892166633187 positive regulation of nitrogen compound metabolic process Set31b: gntK gntu_2 gntu_1 gntT 4 GO:0019520 0.0012072434607645994 aldonic acid metabolic process GO:0046176 0.0033222591362126255 aldonic acid catabolic process Set32a: crp galS 2 Set32b: mglA mglB mglC galS 4 Set33a: trpR tyrR 2 Set33b: mtr yaiA aroL aroM 4 GO:0019438 1.1222085063404396E-4 aromatic compound biosynthetic process GO:0006725 3.840245775729269E-4 cellular aromatic compound metabolic process GO:0009072 7.541478129713464E-4 aromatic amino acid family metabolic process GO:0009073 0.0024630541871921248 aromatic amino acid family biosynthetic process GO:0043648 0.003912363067292677 dicarboxylic acid metabolic process Set34a: betI arcA 2 GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process Set34b: betB betA betI betT 4 GO:0042439 3.1620453374060553E-6 ethanolamine-containing compound metabolic process GO:0006578 3.6937852063902836E-6 betaine biosynthetic process GO:0006575 4.342162396873629E-6 cellular modified amino acid metabolic process GO:0006576 4.342162396873629E-6 cellular biogenic amine metabolic process GO:0006577 7.802007740301131E-6 betaine metabolic process GO:0042398 4.210349037935256E-5 cellular modified amino acid biosynthetic process GO:0044283 6.804491946573645E-4 small molecule biosynthetic process GO:0016053 8.559004663182637E-4 organic acid biosynthetic process GO:0050896 0.0015644564079735441 response to stimulus GO:0006520 0.0019581316923905673 cellular amino acid metabolic process GO:0006970 0.002718212020537619 response to osmotic stress GO:0031455 0.003030303030303028 glycine betaine metabolic process GO:0009628 0.0032730009577395737 response to abiotic stimulus GO:0006082 0.004045988327005562 organic acid metabolic process GO:0042180 0.004045988327005562 cellular ketone metabolic process GO:0044271 0.004543205597075608 cellular nitrogen compound biosynthetic process GO:0009308 0.006389775471391544 amine metabolic process GO:0044106 0.008540928962316802 cellular amine metabolic process Set35a: cbl cysB 2 GO:0006790 7.168458781361301E-4 sulfur compound metabolic process GO:0006791 0.005464480874316705 sulfur utilization Set35b: tauB tauC tauA tauD 4 Set36a: lrp crp 2 Set36b: malT dadA dadX 3 GO:0009078 8.163265306122488E-4 pyruvate family amino acid metabolic process GO:0046416 0.002448979591836745 D-amino acid metabolic process GO:0019480 0.009433962264151104 L-alanine oxidation to pyruvate via D-alanine Set37a: melR crp 2 Set37b: melB melR melA 3 Set38a: exuR uxuR 2 Set38b: uxuB uxuR uxuA 3 GO:0006064 5.464480874317068E-4 glucuronate catabolic process GO:0006063 7.843137254901914E-4 uronic acid metabolic process Set39a: lacI crp 2 Set39b: lacA lacZ lacY 3 GO:0005984 0.0014423076923076644 disaccharide metabolic process GO:0030246 0.0017670682730924387 carbohydrate binding GO:0009311 0.002414486921529199 oligosaccharide metabolic process Set40a: crp malI 2 GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process Set40b: malI malX malY 3 Set41a: narL torR 2 GO:0060089 0.0018436254455425963 molecular transducer activity GO:0023052 0.0020360805449509693 signaling GO:0007154 0.004255319148935838 cell communication Set41b: torD torA torC 3 Set42a: ihf nr(i) 2 Set42b: glnQ glnH glnP 3 GO:0071705 0.00281385281385276 nitrogen compound transport GO:0015837 0.008357685563997784 amine transport Set43a: crp nr(i) 2 Set43b: glnA glnG glnL 3 GO:0071941 5.365274996875355E-4 nitrogen cycle metabolic process GO:0009399 0.002197802197802196 nitrogen fixation GO:0060089 0.005388214843818607 molecular transducer activity GO:0023052 0.005940432798731226 signaling GO:0019740 0.008196721311475955 nitrogen utilization GO:0032501 0.008196721311475955 multicellular organismal process Set44a: rcsab sdiA 2 Set44b: ftsA ftsQ ftsZ 3 GO:0032153 2.4099486536340557E-7 cell division site GO:0032155 2.4099486536340557E-7 cell division site part GO:0000910 6.739498176965387E-7 cytokinesis GO:0051301 6.739498176965387E-7 cell division GO:0007049 6.739498176965387E-7 cell cycle GO:0032506 5.52638850511177E-5 cytokinetic process GO:0071840 0.0013153251419590053 cellular component organization or biogenesis GO:0000917 0.003076923076923083 barrier septum assembly GO:0032502 0.008196721311475955 developmental process GO:0048869 0.009090909090909483 cellular developmental process Set45a: dnaA iciA 2 Set45b: dnaA recF dnaN 3 GO:0006260 6.782419967444106E-5 DNA replication GO:0071897 6.782419967444106E-5 DNA biosynthetic process GO:0006259 5.877858108505535E-4 DNA metabolic process Set46a: arcA lctR 2 Set46b: lctD lctR lctP 3 Set47a: flhdc hns 2 Set47b: fliY fliA fliZ 3 GO:0000988 3.0568971354116874E-4 protein binding transcription factor activity GO:0001047 0.003506721215663378 core promoter binding Set48a: crp hns 2 Set48b: flhC hlyE flhD caiF 4 GO:0048522 5.310229921379808E-4 positive regulation of cellular process GO:0048518 5.428905455445307E-4 positive regulation of biological process GO:0050789 0.00363391380683106 regulation of biological process GO:0065007 0.004146274619704229 biological regulation GO:0050794 0.004690761872086089 regulation of cellular process Set49a: dnaA fis 2 Set49b: nrdA nrdB guaB guaA 4 GO:0034654 1.0897104094586459E-4 nucleobase-containing compound biosynthetic process GO:0055086 7.921984198852672E-4 nucleobase-containing small molecule metabolic process GO:0016725 0.0010810810810810737 oxidoreductase activity, acting on CH or CH2 groups GO:0005971 0.0017631501616220604 ribonucleoside-diphosphate reductase complex GO:0006260 0.0021477663230240274 DNA replication GO:0071897 0.0021477663230240274 DNA biosynthetic process GO:0009126 0.0022988505747126415 purine nucleoside monophosphate metabolic process GO:0009167 0.0024630541871921248 purine ribonucleoside monophosphate metabolic process GO:0044444 0.004528538925348509 cytoplasmic part GO:0044271 0.004543205597075608 cellular nitrogen compound biosynthetic process GO:0006259 0.007788161993769713 DNA metabolic process Set50a: rpoE cpxR 2 Set50b: ecfI htrA 2 Set51a: lrp hns 2 Set51b: stpA osmC 2 Set52a: fur fecI 2 Set52b: fecR fecI 2 GO:0065008 0.002287805994051725 regulation of biological quality Set53a: crp fur 2 Set53b: cirA fur 2 GO:0004872 0.00591715976331269 receptor activity GO:0019725 0.006042296072506534 cellular homeostasis Set54a: crp dsdC 2 Set54b: dsdA dsdX 2 GO:0051410 0.005780346820809282 detoxification of nitrogen compound Set55a: fadR arcA 2 GO:0048522 0.002818458137606834 positive regulation of cellular process GO:0048518 0.0028445242907403287 positive regulation of biological process GO:0009893 0.0033002588438306173 positive regulation of metabolic process GO:0031325 0.0034570411794607836 positive regulation of cellular metabolic process GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process GO:0051173 0.007972892166633187 positive regulation of nitrogen compound metabolic process GO:0008289 0.00799999999999982 lipid binding Set55b: fadB fadA 2 GO:0016042 2.0614306328591288E-4 lipid catabolic process GO:0044255 3.840245775729269E-4 cellular lipid metabolic process GO:0044242 4.2625745950553733E-4 cellular lipid catabolic process GO:0034440 5.390835579514796E-4 lipid oxidation GO:0006629 8.186815328837133E-4 lipid metabolic process Set56a: metJ metR 2 GO:0006790 7.168458781361301E-4 sulfur compound metabolic process GO:0044272 0.0016833127595106603 sulfur compound biosynthetic process Set56b: metR metA 2 GO:0006790 7.168458781361301E-4 sulfur compound metabolic process GO:0044272 0.0016833127595106603 sulfur compound biosynthetic process Set57a: crp dcuR 2 GO:0007154 0.004255319148935838 cell communication Set57b: dctA fumB 2 Set58a: argR ihf 2 Set58b: carB carA 2 GO:0072527 2.2445009726170225E-4 pyrimidine-containing compound metabolic process GO:0005951 2.9385836027034354E-4 carbamoyl-phosphate synthase complex GO:0006725 3.840245775729269E-4 cellular aromatic compound metabolic process GO:0072528 9.66183574879222E-4 pyrimidine-containing compound biosynthetic process GO:0016874 0.001098901098901132 ligase activity GO:0006220 0.0015873015873015955 pyrimidine nucleotide metabolic process GO:0009218 0.0024630541871921248 pyrimidine ribonucleotide metabolic process GO:0009112 0.0031712473572938567 nucleobase metabolic process GO:0046112 0.0073529411764706055 nucleobase biosynthetic process GO:0009064 0.008163265306122483 glutamine family amino acid metabolic process GO:0006221 0.008333333333333312 pyrimidine nucleotide biosynthetic process GO:0009116 0.00900900900900902 nucleoside metabolic process Set59a: crp ebgR 2 GO:0048519 0.003458342690321145 negative regulation of biological process GO:0048523 0.0038450975006859216 negative regulation of cellular process GO:0009892 0.00452976704055184 negative regulation of metabolic process GO:0031324 0.0053763440860209585 negative regulation of cellular metabolic process Set59b: ebgA ebgC 2 Set60a: hns cadC 2 Set60b: cadA cadB 2 Set61a: gntR fruR 2 Set61b: eda edd 2 GO:0009255 0.006451612903225771 Entner-Doudoroff pathway Set62a: rhasr rhaR 2 Set62b: rhaS rhaR 2