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["Rxn name","Rxn description","Formula","GPR association","Protein","Subsystem","ConfidenceScore","E.C. number","Metabolism","References"]
["R1","phosphoglucomutase","g1p <=> g6p","MMP1077",null,"Glycolysis / Gluconeogenesis",4,"5.4.2.2","Carbohydrate metabolism",5]
["R2","ADP-specific glucokinase","adp + glc -> amp + g6p","MMP1296","pfkC","Glycolysis / Gluconeogenesis",5,"2.7.1.147","Carbohydrate metabolism","1,2"]
["R3","glyceraldehyde-3-phosphate dehydrogenase (NADP+)","g3p + nadp + h2o -> 3pg + nadph + h","MMP1487","gapN","Glycolysis / Gluconeogenesis",5,"1.2.1.9","Carbohydrate metabolism","1,2"]
["R4","phosphoglycerate kinase","atp + 3pg <=> adp + 13dpg","MMP1532","pgk","Glycolysis / Gluconeogenesis",5,"2.7.2.3","Carbohydrate metabolism","1,2"]
["R5","phosphoglycerate mutase","2pg <=> 3pg","(MMP0112 or MMP1439 or MMP0598)","","Glycolysis / Gluconeogenesis",5,"5.4.2.1","Carbohydrate metabolism","1,2"]
["R6","phosphopyruvate hydratase","2pg <=> pep + h2o","MMP0396","eno","Glycolysis / Gluconeogenesis",5,"4.2.1.11","Carbohydrate metabolism","1,2"]
["R7","pyruvate kinase","atp + pyr <=> adp + pep","MMP1605","","Glycolysis / Gluconeogenesis",5,"2.7.1.40","Carbohydrate metabolism","1,2"]
["R8","pyruvate synthase","2 fdox + coa + pyr <=> 2 fdxrd + accoa + co2 + 2 h","(MMP1504 and MMP1505 and MMP1506 and MMP1507)","(porB and porA and porD and porC)","Glycolysis / Gluconeogenesis",5,"1.2.7.1","Carbohydrate metabolism","1,2"]
["R9","dihydrolipoyl dehydrogenase","en6lip + nad <=> e6lip + nadh + h","MMP1332","","Glycolysis / Gluconeogenesis",5,"1.8.1.4","Carbohydrate metabolism","1,2"]
["R10","alcohol dehydrogenase","etoh + nad <=> acald + nadh + h","MMP0802","","Glycolysis / Gluconeogenesis",5,"1.1.1.1","Carbohydrate metabolism","1,2"]
["R11","glucose-6-phosphate isomerase","g6p <=> f6p","MMP1295",null,"Glycolysis / Gluconeogenesis",5,"5.3.1.9","Carbohydrate metabolism","1,2"]
["R12","fructose-bisphosphatase","fpp + h2o -> f6p + pi","MMP0317","","Glycolysis / Gluconeogenesis",5,"3.1.3.11","Carbohydrate metabolism","1,2"]
["R13","fructose-bisphosphate aldolase","fpp <=> dhap + g3p","(MMP0293 or MMP0317 or MMP0686)","","Glycolysis / Gluconeogenesis",5,"4.1.2.13","Carbohydrate metabolism","1,2"]
["R14","triose-phosphate isomerase","g3p <=> dhap","MMP0687","tpiA","Glycolysis / Gluconeogenesis",5,"5.3.1.1","Carbohydrate metabolism","1,2"]
["R15","glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)","g3p + pi + nad <=> 13dpg + nadh + h","MMP0325","","Glycolysis / Gluconeogenesis",5,"1.2.1.59","Carbohydrate metabolism","1,2"]
["R16","glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)","g3p + pi + nadp <=> 13dpg + nadph + h","MMP0325","","Glycolysis / Gluconeogenesis",5,"1.2.1.59","Carbohydrate metabolism","1,2"]
["R17","glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)","g3p + h2o + 2 fdox -> 3pg + 2 h + 2 fdxrd","MMP0945","","Glycolysis / Gluconeogenesis",5,"1.2.7.6","Carbohydrate metabolism","1,2"]
["R18","malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)","mal + nadp -> nadph + pyr + co2 + h","","","Glycolysis / Gluconeogenesis",3,"1.1.1.40","Carbohydrate metabolism",3]
["R19","malate dehydrogenase (oxaloacetate-decarboxylating)","mal + nad -> nadh + pyr + h + co2","",null,"Glycolysis / Gluconeogenesis",3,"1.1.1.38","Carbohydrate metabolism",3]
["R20","pyruvate synthase","2 fdxrd + co2 + 2 h + ppcoa -> 2 fdox + 2 2oxbut + coa","(MMP1504 and MMP1505 and MMP1506 and MMP1507) ","(porA and porB and porC and porD)","Glycolysis / Gluconeogenesis",5,"1.2.7.1","Carbohydrate metabolism","1,2"]
["R21","phosphoenolpyruvate carboxykinase (ATP)","oaa + atp -> adp + co2 + pep","",null,"Glycolysis / Gluconeogenesis",3,"4.1.1.49","Carbohydrate metabolism","3,16"]
["R22","phosphoenolpyruvate carboxylase","oaa + pi <=> h2o + co2 + pep","",null,"Glycolysis / Gluconeogenesis",3,"4.1.1.31","Carbohydrate metabolism",3]
["R23","acetate CoA ligase","atp + acetate + coa -> accoa + amp + ppi","(MMP0148 or MMP1274)","acsA","Glycolysis / Gluconeogenesis",5,"6.2.1.1","Carbohydrate metabolism","1,2"]
["R24","acetate CoA ligase","accoa + adp + pi -> acetate + atp + coa","MMP0253","acd","Glycolysis / Gluconeogenesis",5,"6.2.1.13","Carbohydrate metabolism","1,2"]
["R25","pyruvate carboxylase","atp + pyr + hco3 + h -> adp + pi + oaa","(MMP0340 and MMP0341)","(pycB and pycA)","Citrate cycle",5,"6.4.1.1 4.1.1.3","Carbohydrate metabolism","1,2"]
["R26","malate dehydrogenase","mal + nad <=> oaa + nadh + h","MMP0645","mdh","Citrate cycle",5,"1.1.1.37","Carbohydrate metabolism","1,2"]
["R27","fumarate hydratase","mal <=> fum + h2o","(MMP0130 and MMP1548)","fumA","Citrate cycle",5,"4.2.1.2","Carbohydrate metabolism","1,2"]
["R28","succinate---CoA ligase (ADP-forming)","atp + succ + coa <=> adp + pi + succoa","(MMP0955 and MMP1105)","(sucD and sucC)","Citrate cycle",5,"6.2.1.5","Carbohydrate metabolism","1,2"]
["R29","2-oxoglutarate synthase","2 fdxrd + succoa + co2 + 2 h -> 2 fdox + 2oxglu + coa","(MMP0003 and MMP0305 and MMP0306 and MMP1315 and MMP1316 and MMP1687)","(korA and korG and korB and korD)","Citrate cycle",5,"1.2.7.3","Carbohydrate metabolism","1,2"]
["R30","ADP-specific phosphofructokinase","adp + f6p -> amp + fpp","MMP1296","pfkC","Pentose phosphate pathway",5,"2.7.1.146","Carbohydrate metabolism","1,2"]
["R31","ribulose-phosphate 3-epimerase","ru5p <=> x5p","MMP1114","rpe","Pentose phosphate pathway",5,"5.1.3.1","Carbohydrate metabolism","1,2"]
["R32","ribokinase","atp + rib-D <=> adp + r5p","MMP0418","PfkB","Pentose phosphate pathway",5,"2.7.1.15","Carbohydrate metabolism","1,2"]
["R33","ribose-5-phosphate isomerase","r5p <=> ru5p","MMP1189",null,"Pentose phosphate pathway",5,"5.3.1.6","Carbohydrate metabolism","1,2"]
["R34","ribose-phosphate diphosphokinase","atp + r5p <=> amp + prpp","MMP0410","prsA","Pentose phosphate pathway",5,"2.7.6.1","Carbohydrate metabolism","1,2"]
["R35","6-phospho-3-hexuloisomerase","ahup <=> f6p","MMP1270",null,"Pentose phosphate pathway",5,"5.3.1.27","Carbohydrate metabolism","1,2"]
["R36","transketolase","s7p + g3p <=> r5p + x5p","(MMP1113 and MMP1115)",null,"Pentose phosphate pathway",5,"2.2.1.1","Carbohydrate metabolism","1,2"]
["R37","transaldolase","s7p + g3p <=> e4p + f6p","MMP1308","tal","Pentose phosphate pathway",5,"2.2.1.2","Carbohydrate metabolism","1,2"]
["R38","transketolase","f6p + g3p <=> e4p + x5p","(MMP1113 and MMP1115)",null,"Pentose phosphate pathway",5,"2.2.1.1","Carbohydrate metabolism","1,2"]
["R39","3-hexulose-6-phosphate synthase","ru5p + fald <=> ahup","MMP1270",null,"Pentose phosphate pathway",5,"4.1.2.43","Carbohydrate metabolism","1,2"]
["R40","phosphopentomutase","r1p <=> r5p","","","Pentose phosphate pathway",4,"5.4.2.2","Carbohydrate metabolism",5]
["R41","ferredoxin hydrogenase;energy-converting hydrogenase","2 fdox + h2 <=> 2 fdxrd + 2 h","(MMP1448 and MMP1449 and MMP1450 and MMP1451 and MMP1452 and MMP1453 and MMP1454 and MMP1455 and MMP1456 and MMP1457 and MMP1458 and MMP1459 and MMP1460 and MMP1461 and MMP1462 and MMP1463) or (MMP1464 and MMP1465 and MMP1466 and MMP1467 and MMP0400 and MMP0940 and MMP1049 and MMP1073 and MMP1074 and MMP1153 and MMP1469 and MMP1621 and MMP1622 and MMP1623 and MMP1624 and MMP1625 and MMP1626 and MMP1627 and MMP1628 and MMP1629)","(ehaA and ehaB and ehaC and ehaD and ehaE and ehaF and ehaG and ehaH and ehaI and ehaJ and ehaK and ehaL and ehaM and ehaN and ehaO and ehaP and ehaQ and ehaR and ehaS and ehaT) or (ehbQ and ehbC and ehbD and ehbN and ehbA and ehbO and ehbM and ehbL and ehbK and ehbJ and ehbG and ehbF and ehbE)","Methane Metabolism",5,"1.12.7.2 1.12.99.- 1.6.5.3","Energy metabolism","1,2"]
["R42","formylmethanofuran dehydrogenase","fmfr + h2o -> formate + mfr","(MMP0070 and MMP0200 and MMP0508 and MMP0509 and MMP0510 and MMP0511 and MMP0512 and MMP0965 and MMP1244 and MMP1245 and MMP1246 and MMP1247 and MMP1248 and MMP1249 and MMP1691)","(fmdE and fmdA and fmdC and fmdB and fwdH and fwdF and fwdG and fwdD and fwdA and fwdC and fwdB)","Methane Metabolism",5,"1.2.99.5","Energy metabolism","1,2"]
["R43","formylmethanofuran---tetrahydromethanopterin N-formyltransferase","fmfr + thmpt <=> mfr + fthmpt","MMP1609","ftr","Methane Metabolism",5,"2.3.1.101","Energy metabolism","1,2"]
["R44","5,10-methenyltetrahydromethanopterin hydrogenase","methmpt + h2 -> mtthmpt + h","(MMP0127 or MMP1716)","(hmd or hmdII)","Methane Metabolism",5,"1.12.98.2","Energy metabolism","1,2"]
["R45","methenyltetrahydromethanopterin cyclohydrolase","fthmpt + h -> methmpt + h2o","MMP1191","mch","Methane Metabolism",5,"3.5.4.27","Energy metabolism","1,2"]
["R46"," F420-dependent methylenetetrahydromethanopterin dehydrogenase","mtthmpt + cof420h2 <=> cof420 + methmpt","MMP0372","mtd","Methane Metabolism",5,"1.5.99.9","Energy metabolism","1,2"]
["R47","7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase","34hpp + aribau + 2 sam + h2o -> ddhrb + 2 met + 2 dasn + oxa + nh3","(MMP0056 and MMP0057 and MMP0876)","(cofH and cofG)","Methane Metabolism",5,"2.5.1.77","Energy metabolism","1,2"]
["R48","2-phospho-L-lactate transferase","ddhrb + ldpg -> cof420-0 + gmp","MMP0404","cofD","Methane Metabolism",5,"2.7.8.28","Energy metabolism","1,2"]
["R49","coenzyme F420-0:L-glutamate ligase","cof420-0 + gtp + glu -> cof420-1 + gdp + pi","MMP0937","cofE","Methane Metabolism",5,"6.3.2.31","Energy metabolism","1,2"]
["R50","coenzyme F420-1:gamma-L-glutamate ligase","cof420-1 + gtp + glu -> cof420 + gdp + pi","MMP0937","cofE","Methane Metabolism",5,"6.3.2.34","Energy metabolism","1,2"]
["R51","2-phospho-L-lactate guanylyltransferase","2plac + gtp -> ldpg + ppi","MMP0117",null,"Methane Metabolism",5,"2.7.7.68","Energy metabolism","1,2"]
["R52","coenzyme gamma-F420-2:alpha-L-glutamate ligase","atp + cof420 + glu -> adp + cof420-3 + pi","MMP0170","cofF","Methane Metabolism",5,"6.3.2.32","Energy metabolism","1,2"]
["R53","5,10-methylenetetrahydromethanopterin reductase","mtthmpt + cof420h2 <=> mthmpt + cof420","MMP0058","mer","Methane Metabolism",5,"1.5.99.11","Energy metabolism","1,2"]
["R54","acetyl-CoA decarbonylase/synthase complex","accoa + thmpt + h <=> mthmpt + co + coa","(MMP0980 and MMP0981 and MMP0983)","(cdh and cdhD and cdhB)","Methane Metabolism",5,"2.1.1.245","Energy metabolism","1,2"]
["R55","tetrahydromethanopterin S-methyltransferase","mthmpt + COM + na <=> thmpt + mteths + na_e","(MMP1560 and MMP1561 and MMP1562 and MMP1563 and MMP1564 and MMP1565 and MMP1566 and MMP1567)","(mtrE and mtrD and mtrC and mtrB and mtrA and or900 and mtrG and mtrH)","Methane Metabolism",5,"2.1.1.86","Energy metabolism","1,2"]
["R56","coenzyme-B sulfoethylthiotransferase","cob + mteths -> com-s-s-cob + ch4","(MMP1555 and MMP1556 and MMP1557 and MMP1558 and MMP1559)","(mcrA and mcrB and mcrD and mcrC and mcrG and mcrA)","Methane Metabolism",5,"2.8.4.1 1.8.-.-","Energy metabolism","1,2"]
["R57","CoB CoM heterodisulfide reductase;coenzyme F420-non-reducing hydrogenase","com-s-s-cob + dhmtpz -> COM + cob + mthp","(MMP0825 and MMP1053 and MMP1054 and MMP1154 and MMP1155 and MMP1697 and MMP0823 and MMP1694)","(hdrA and hdrB2 and hdrC2 and hdrC1 and hdrB1 and hdrA and vhcD and vhuD)","Methane Metabolism",5,"1.8.98.1 1.12.99.-","Energy metabolism","1,2"]
["R58","phosphosulfolactate synthase","so3 + pep -> pslac","MMP0273","comA","Methane Metabolism",5,"4.4.1.19","Energy metabolism","1,2"]
["R59","2-phosphosulfolactate phosphatase","pslac + h2o -> slac + pi","MMP0161","comB","Methane Metabolism",5,"3.1.3.71","Energy metabolism","1,2"]
["R60","(R)-2-hydroxyacid dehydrogenase","slac + nad -> 3spyr + nadh + h","MMP1133","comC","Methane Metabolism",5,"1.1.1.272","Energy metabolism","1,2"]
["R61","(R)-2-hydroxyacid dehydrogenase","slac + nadp -> 3spyr + nadph + h","MMP1133","comC","Methane Metabolism",5,"1.1.1.272","Energy metabolism","1,2"]
["R62","sulfopyruvate decarboxylase","3spyr -> sald + co2","(MMP0411 and MMP1689)","(comD and comE)","Methane Metabolism",5,"4.1.1.79","Energy metabolism","1,2"]
["R63","carbonate dehydratase","co2 + h2o <=> hco3 + h","MMP1299",null,"Methane Metabolism",5,"4.2.1.1","Energy metabolism","1,2"]
["R64","spontaneous reaction","thf + fald -> mlthf + h2o","",null,"Methane Metabolism",3,"Non-enzymatic reaction","Energy metabolism",3]
["R65","5,10-methylenetetrahydromethanopterin:glycine hydroxymethyltransferase","ser + thmpt -> mtthmpt + gly + h2o","",null,"Methane Metabolism",2,"2.1.2.1","Energy metabolism",11]
["R66","carbon-monoxide dehydrogenase (acceptor)","co2 + fdxrd <=> co + h2o + fdox","(MMP1502 and MMP1503) or (MMP0984 and MMP0985)","(porF and porE) or (cdh and cdhA and porF and porE)","Methane Metabolism",5,"1.2.99.2 1.2.7.4","Energy metabolism","1,2"]
["R67","formylmethanofuran dehydrogenase","co2 + mfr + nadh + h <=> fmfr + h2o + nad","(MMP0070 and MMP0200 and MMP0508 and MMP0509 and MMP0510 and MMP0511 and MMP0512 and MMP0965 and MMP1244 and MMP1245 and MMP1246 and MMP1247 and MMP1248 and MMP1249 and MMP1691)","(fmdE and fmdA and fmdC and fmdB and fwdH and fwdF and fwdG and fwdD and fwdA and fwdC and fwdB)","Methane Metabolism",5,"1.2.99.5","Energy metabolism","1,2"]
["R68","Hydrogenases","h2 <=> 2 h + 2 electron","",null,"Methane Metabolism",2,"1.18.6.1","Energy metabolism",14]
["R69","NAD+ synthase","atp + dnad + nh3 -> amp + ppi + nad","MMP1349",null,"Nitrogen metabolism",5,"6.3.1.5","Energy metabolism","1,2"]
["R70","asparagine synthase (glutamine-hydrolysing)","gln + h2o -> glu + nh3","MMP0918","asnB","Nitrogen metabolism",5,"6.3.5.4","Energy metabolism","1,2"]
["R71","glutamate---ammonia ligase","atp + glu + nh3 -> adp + pi + gln","MMP1206","glnA","Nitrogen metabolism",5,"6.3.1.2","Energy metabolism","1,2"]
["R72","nitrogenase","16 atp + n2 + 8 fdxrd + 8 h + 16 h2o -> 16 pi + 16 adp + 8 fdox + 2 nh3 + h2","(MMP0147 and MMP0853 and MMP0856 and MMP0857 and MMP0858 and MMP0859 and MMP0860)","(nifH and nifD and nifK and nifE and nifN and nifX)","Nitrogen metabolism",5,"1.18.6.1","Energy metabolism","1,2"]
["R73","carbonic anhydrase","cba <=> co2 + h2o","(MMP0049 and MMP1299)",null,"Nitrogen metabolism",5,"4.2.1.1","Energy metabolism","1,2"]
["R74","Ammonium dissociation","nh4 -> h + nh3","",null,"Ammonium dissociation",2]
["R75","succinate dehydrogenase","succ + fad <=> fadh2 + fum","(MMP1067 or MMP1277)","(sdhA or FrdB)","Oxidative phosphorylation",5,"1.3.99.1 1.3.5.1","Energy metabolism","1,2"]
["R76","H+-transporting two-sector ATPase","adp + pi + 3 h_e <=> atp + h2o + 3 h","(MMP1038 and MMP1039 and MMP1040 and MMP1041 and MMP1042 and MMP1043 and MMP1044 and MMP1045 and MMP1046)","(atpH and atpI and atpK and atpE and atpC and atpF and atpA and atpB and atpD)","Oxidative phosphorylation",5,"3.6.3.14","Energy metabolism","1,2"]
["R77","inorganic diphosphatase","ppi + h2o -> 2 pi","MMP0219","ppaC","Oxidative phosphorylation",5,"3.6.1.1","Energy metabolism","1,2"]
["R78","ATP_maintenance","atp + h2o -> adp + pi","","","Oxidative phosphorylation",5,"","Energy metabolism","1,2"]
["R79","ATP phosphoribosyltransferase","atp + prpp <=> pratp + ppi","MMP0947","hisG","Histidine metabolism",5,"2.4.2.17","Amino acid metabolism","1,2"]
["R80","phosphoribosyl-ATP diphosphatase","pratp + h2o -> pramp + ppi","MMP0051","hisE","Histidine metabolism",5,"3.6.1.31","Amino acid metabolism","1,2"]
["R81","phosphoribosyl-AMP cyclohydrolase","pramp + h2o -> prfa","MMP0280","hisI","Histidine metabolism",5,"3.5.4.19","Amino acid metabolism","1,2"]
["R82","1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase","prfa -> prufa","(MMP1690 or MMP0417)","hisA","Histidine metabolism",5,"5.3.1.16","Amino acid metabolism","1,2"]
["R83","imidazoleglycerol-phosphate dehydratase","ig3p -> iacp + h2o","MMP0548","hisB","Histidine metabolism",5,"4.2.1.19","Amino acid metabolism","1,2"]
["R84","histidinol-phosphate transaminase","iacp + glu -> hislp + 2oxglu","MMP1216","hisC","Histidine metabolism",5,"2.6.1.9","Amino acid metabolism","1,2"]
["R85","histidinol dehydrogenase","hisl + nad -> hisal + nadh + h","MMP0968","hisD","Histidine metabolism",5,"1.1.1.23","Amino acid metabolism","1,2"]
["R86","histidinol dehydrogenase","hisal + h2o + nad -> his + nadh + h","MMP0968","hisD","Histidine metabolism",5,"1.1.1.23","Amino acid metabolism","1,2"]
["R87","histidinol-phosphatase","hislp + h2o -> hisl + pi","",null,"histidine biosynthesis",3,"3.1.3.15","Amino acid metabolism",3]
["R88","histidine biosynthesis","prufa + gln -> ig3p + glu + aicar","(MMP1083 or MMP1722)","(hisH or hisF)","histidine biosynthesis",5,"2.4.2.-","Amino acid metabolism","1,2"]
["R89","3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)","4mop + coa + 2 fdox -> mbcoa + co2 + 2 fdxrd + h","(MMP1271 and MMP1272 and MMP1273)","(vorA and vorB and vorC)","Valine, leucine and isoleucine degradation",5,"1.2.7.7","Amino acid metabolism","1,2"]
["R90","branched-chain-amino-acid transaminase","leu + 2oxglu <=> 4mop + glu","MMP0132","","Valine, leucine and isoleucine degradation",5,"2.6.1.42","Amino acid metabolism","1,2"]
["R91","branched-chain-amino-acid transaminase","val + 2oxglu <=> 2oival + glu","MMP0132","","Valine, leucine and isoleucine degradation",5,"2.6.1.42","Amino acid metabolism","1,2"]
["R92","3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)","2oival + coa + 2 fdox -> mpcoa + co2 + 2 fdxrd + h","(MMP1271 and MMP1272 and MMP1273)","(vorA and vorB and vorC)","Valine, leucine and isoleucine degradation",5,"1.2.7.7","Amino acid metabolism","1,2"]
["R93","branched-chain-amino-acid transaminase","ile + 2oxglu <=> 3mop + glu","MMP0132","","Valine, leucine and isoleucine degradation",5,"2.6.1.42","Amino acid metabolism","1,2"]
["R94","3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)","3mop + coa + 2 fdox -> s2mbcoa + co2 + 2 fdxrd + h","(MMP1271 and MMP1272 and MMP1273)","(vorA and vorB and vorC)","Valine, leucine and isoleucine degradation",5,"1.2.7.7","Amino acid metabolism","1,2"]
["R95","3-isopropylmalate dehydrogenase","emm + nad -> 2oxbut + co2 + nadh + h","MMP0539","leuB","Valine, leucine and isoleucine biosynthesis",5,"1.1.1.85","Amino acid metabolism","1,2"]
["R96","acetolactate synthase","2oxbut + 2hethpp -> 2ahbut + thpp","MMP0650","ilvB","Valine, leucine and isoleucine biosynthesis",5,"2.2.1.6","Amino acid metabolism","1,2"]
["R97","ketol-acid reductoisomerase","2ahbut <=> 3h3mop","MMP0654","ilvC","Valine, leucine and isoleucine biosynthesis",5,"1.1.1.86","Amino acid metabolism","1,2"]
["R98","ketol-acid reductoisomerase","23h3mop + nadp <=> 3h3mop + nadph + h","MMP0654","ilvC","Valine, leucine and isoleucine biosynthesis",5,"1.1.1.86","Amino acid metabolism","1,2"]
["R99","dihydroxy-acid dehydratase","23h3mop -> 3mop + h2o","MMP0318","ilvD","Valine, leucine and isoleucine biosynthesis",5,"4.2.1.9","Amino acid metabolism","1,2"]
["R100","ketol-acid reductoisomerase","alac-S <=> hmoa","MMP0654","ilvC","Valine, leucine and isoleucine biosynthesis",5,"1.1.1.86","Amino acid metabolism","1,2"]
["R101","ketol-acid reductoisomerase","23dhmb + nadp <=> hmoa + nadph + h","MMP0654","ilvC","Valine, leucine and isoleucine biosynthesis",5,"1.1.1.86","Amino acid metabolism","1,2"]
["R102","dihydroxy-acid dehydratase","23dhmb -> 2oival + h2o","MMP0318","ilvD","Valine, leucine and isoleucine biosynthesis",5,"4.2.1.9","Amino acid metabolism","1,2"]
["R103","(R)-citramalate synthase","accoa + pyr + h2o -> r2mm + coa","MMP1018","cimA","Valine, leucine and isoleucine biosynthesis",5,"2.3.1.182","Amino acid metabolism","1,2"]
["R104","3-isopropylmalate dehydratase","2sipmal <=> 2ipmal + h2o","(MMP0136 and MMP1149)","(leuD and leuC)","Valine, leucine and isoleucine biosynthesis",5,"4.2.1.33","Amino acid metabolism","1,2"]
["R105","3-isopropylmalate dehydratase","2r3sipmal <=> 2ipmal + h2o","(MMP0136 and MMP1149)","(leuD and leuC)","Valine, leucine and isoleucine biosynthesis",5,"4.2.1.33","Amino acid metabolism","1,2"]
["R106","3-isopropylmalate dehydrogenase","2r3sipmal + nad <=> 2ip3os + nadh + h","MMP0539","leuB","Valine, leucine and isoleucine biosynthesis",5,"1.1.1.85","Amino acid metabolism","1,2"]
["R107","acetolactate synthase","pyr + thpp -> 2hethpp + co2","(MMP0142 and MMP0650 and MMP0651)","(ilvB and ilvH)","Valine, leucine and isoleucine biosynthesis",5,"2.2.1.6","Amino acid metabolism","1,2"]
["R108","2-isopropylmalate synthase","accoa + 2oival + h2o -> 2sipmal + coa","MMP1063","leuA","Valine, leucine and isoleucine biosynthesis",5,"2.3.3.13","Amino acid metabolism","1,2"]
["R109","3-isopropylmalate dehydrogenase","2ip3os -> 4mop + co2","MMP0539","leuB","leucine biosynthesis",5,"1.1.1.85","Amino acid metabolism","1,2"]
["R110","(R)-2-methylmalate dehydratase","2mm + h2o -> emm","(MMP0136 and MMP1149)","(leuD and leuC)","isoleucine biosynthesis II",5,"4.2.1.35","Amino acid metabolism",3]
["R111","short-chain acyl-CoA dehydrogenase","s2mbcoa + fad -> fadh2 + mbecoa","",null,"isoleucine degradation I",3,"1.3.8.1","Amino acid metabolism",3]
["R112","enoyl-CoA hydratase","mbecoa + h2o -> 3h2mbcoa","",null,"isoleucine degradation I",3,"4.2.1.17","Amino acid metabolism",3]
["R113","3-hydroxy-2-methylbutyryl-CoA dehydrogenase","3h2mbcoa + nad -> nadh + h + maacoa","",null,"isoleucine degradation I",3,"1.1.1.178","Amino acid metabolism",3]
["R114","acetyl-CoA C-acetyltransferase","maacoa + coa -> accoa + ppcoa","MMP1212",null,"isoleucine degradation I",5,"2.3.1.9","Amino acid metabolism",3]
["R115","alanine dehydrogenase","pyr + nh3 + nadh + h <=> ala + nad + h2o","MMP1513","ald","Alanine, aspartate and glutamate metabolism",5,"1.4.1.1","Amino acid metabolism","1,2"]
["R116","amidophosphoribosyltransferase","gln + prpp + h2o -> pram + ppi + glu","MMP1146","purF","Alanine, aspartate and glutamate metabolism",5,"2.4.2.14","Amino acid metabolism","1,2"]
["R117","argininosuccinate synthase","atp + citr + asp -> amp + ppi + args5p","MMP0073","argG","Alanine, aspartate and glutamate metabolism",5,"6.3.4.5","Amino acid metabolism","1,2"]
["R118","argininosuccinate lyase","args5p -> fum + arg","MMP0013","argH","Alanine, aspartate and glutamate metabolism",5,"4.3.2.1","Amino acid metabolism","1,2"]
["R119","aspartate racemase","asp -> asp-d","MMP0739","","Alanine, aspartate and glutamate metabolism",5,"5.1.1.13","Amino acid metabolism","1,2"]
["R120","asparagine synthase (glutamine-hydrolysing)","atp + asp + nh3 <=> amp + ppi + asn","MMP0918","asnB","Alanine, aspartate and glutamate metabolism",5,"6.3.5.4","Amino acid metabolism","1,2"]
["R121","aspartate transaminase","oaa + glu <=> asp + 2oxglu",null,"aspC","Alanine, aspartate and glutamate metabolism",5,"2.6.1.1","Amino acid metabolism","1,2"]
["R122","glutamate synthase (NADPH","gln + 2oxglu + nadph + h -> 2 glu + nadp","(MMP0496 and MMP0082 and MMP0080)","gltB","glutamate biosynthesis I",5,"1.4.1.13","Amino acid metabolism",3]
["R123","asparagine synthase (glutamine-hydrolysing)","atp + asp + h2o + glu <=> amp + ppi + asn + glu","MMP0918","asnB","Alanine, aspartate and glutamate metabolism",5,"6.3.5.4","Amino acid metabolism","1,2"]
["R124","glutamate synthase (NADH","gln + nadh + 2oxglu + h -> nad + 2 glu","(MMP0496 and MMP0082 and MMP0080)","gltB","glutamate biosynthesis I ",5,"1.4.1.4","Amino acid metabolism",3]
["R125","glutamate dehydrogenase (NADP+)","nh3 + nadph + 2oxglu + h -> nadp + glu + h2o","(MMP0496 and MMP0082 and MMP0080)","gltB","glutamate biosynthesis III",5,"1.4.1.4","Amino acid metabolism",3]
["R126","CDP-diacylglycerol serine O-phosphatidyltransferase","cdpdg + ser -> cmp + ps","MMP1171","pssA","Glycine, serine and threonine metabolism",5,"2.7.8.8","Amino acid metabolism","1,2"]
["R127","threonine synthase","ophser + h2o -> thr + pi","MMP0135","thrC","Glycine, serine and threonine metabolism",5,"4.2.3.1","Amino acid metabolism","1,2"]
["R128","homoserine kinase","atp + hser -> adp + ophser","MMP0295","thrB","Glycine, serine and threonine metabolism",5,"2.7.1.39","Amino acid metabolism","1,2"]
["R129","homoserine dehydrogenase","hser + nad <=> asp4sa + nadh + h","MMP1702","hom","Glycine, serine and threonine metabolism",5,"1.1.1.3","Amino acid metabolism","1,2"]
["R130","homoserine dehydrogenase","hser + nadp <=> asp4sa + nadph + h","MMP1702","hom","Glycine, serine and threonine metabolism",5,"1.1.1.3","Amino acid metabolism","1,2"]
["R131","aspartate kinase","atp + asp -> adp + 4pasp","MMP1017","lysC","Glycine, serine and threonine metabolism",5,"2.7.2.4","Amino acid metabolism","1,2"]
["R132","tryptophan synthase","ser + igp <=> trp + g3p + h2o","(MMP1002 and MMP1003)","(trpA and trpB)","Glycine, serine and threonine metabolism",5,"4.2.1.20","Amino acid metabolism","1,2"]
["R133","dihydrolipoyl dehydrogenase","dplr + nad -> lprtn + nadh + h","MMP1332","","Glycine, serine and threonine metabolism",5,"1.8.1.4","Amino acid metabolism","1,2"]
["R134","phosphoserine transaminase","glu + 3phpyr -> 3pser + 2oxglu","","","serine biosynthesis",3,"2.6.1.52","Amino acid metabolism",3]
["R135","phosphoserine phosphatase","3pser + h2o -> ser + pi","MMP0541","serB","Glycine, serine and threonine metabolism",5,"3.1.3.3","Amino acid metabolism","1,2"]
["R136","phosphoglycerate dehydrogenase","3pg + nad <=> 3phpyr + nadh + h","MMP1588","serA","Glycine, serine and threonine metabolism",5,"1.1.1.95","Amino acid metabolism","1,2"]
["R137","aspartate-semialdehyde dehydrogenase","4pasp + nadph + h -> asp4sa + pi + nadp","MMP1391","asd","Cysteine and methionine metabolism",5,"1.2.1.11","Amino acid metabolism","1,2"]
["R138","aspartate transaminase","cys + 2oxglu <=> mpyr + glu","MMP1527","","Cysteine and methionine metabolism",5,"2.6.1.1","Amino acid metabolism","1,2"]
["R139","aspartate transaminase","cys + 2oxglu <=> mpyr + dlglu","MMP1527","","Cysteine and methionine metabolism",5,"2.6.1.1","Amino acid metabolism","1,2"]
["R140","aspartate transaminase","cysteate + 2oxglu <=> 3spyr + glu","MMP1527","","Cysteine and methionine metabolism",5,"2.6.1.1","Amino acid metabolism","1,2"]
["R141","aspartate transaminase","3slala + 2oxglu -> 3sfpyr + glu","MMP1527","","Cysteine and methionine metabolism",5,"2.6.1.1","Amino acid metabolism","1,2"]
["R142","(R)-2-hydroxyacid dehydrogenase","3spyr + nadh + h <=> 3slac + nad","MMP1133","comC","Cysteine and methionine metabolism",5,"1.1.1.272","Amino acid metabolism","1,2"]
["R143","adenosylhomocysteinase","sahc + h2o -> adn + hcys","MMP0920","ahcY","Cysteine and methionine metabolism",5,"3.3.1.1","Amino acid metabolism","1,2"]
["R144","5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase","5mthg_e + hcys -> mthg_e + met","MMP0401",null,"Cysteine and methionine metabolism",5,"2.1.1.14","Amino acid metabolism","1,2"]
["R145","DNA (cytosine-5-)-methyltransferase","dna + sam -> dna5mc + sahc","MMP0011","","Cysteine and methionine metabolism",5,"2.1.1.37","Amino acid metabolism","1,2"]
["R146","methionine adenosyltransferase","atp + met + h2o -> pi + ppi + sam","MMP1640","","Cysteine and methionine metabolism",5,"2.5.1.6","Amino acid metabolism","1,2"]
["R147","adenosylmethionine decarboxylase","sam + h -> sama + co2","MMP1583","","Cysteine and methionine metabolism",5,"4.1.1.50","Amino acid metabolism","1,2"]
["R148","S-methyl-5'-thioadenosine phosphorylase","5mta + pi -> ade + mtr1p","MMP0185","mtaP","Cysteine and methionine metabolism",5,"2.4.2.28","Amino acid metabolism","1,2"]
["R149","cystathionine gamma-lyase","lct + h2o <=> cys + nh3 + 2oxbut","",null,"Cysteine and methionine metabolism",4,"4.4.1.1","Amino acid metabolism",14]
["R150","cystathionine beta-lyase","lct + h2o -> hcys + nh3 + pyr","MMP1072","metC","Cysteine and methionine metabolism",4,"4.4.1.8","Amino acid metabolism",14]
["R151","S-methyl-5'-thioadenosine phosphorylase","5mta + pi <=> mtr1p + ade","MMP0185","mtaP","Cysteine and methionine metabolism",5,"2.4.2.28","Amino acid metabolism","1,2"]
["R152","adenosylhomocysteine nucleosidase","sahc + h2o -> srhc + ade","",null,"Cysteine and methionine metabolism",3,"3.2.2.9","Amino acid metabolism",3]
["R153","S-ribosylhomocysteine lyase","srhc -> hcys + dhptdn","",null,"Cysteine and methionine metabolism",3,"4.4.1.21","Amino acid metabolism",3]
["R154","dihydrodipicolinate synthase","asp4sa + pyr -> 23dpa + 2 h2o","MMP0576","dapA","Lysine biosynthesis",5,"4.2.1.52","Amino acid metabolism","1,2"]
["R155","dihydrodipicolinate reductase","tdpa + nadp <=> 23dpa + nadph + h","MMP0923","dapB","Lysine biosynthesis",5,"1.3.1.26","Amino acid metabolism","1,2"]
["R156","dihydrodipicolinate reductase","tdpa + nadp -> 23dpa + nadph + h","MMP0923","dapB","Lysine biosynthesis",5,"1.3.1.26","Amino acid metabolism","1,2"]
["R157","succinyldiaminopimelate transaminase","s26dap + 2oxglu <=> sdaop + glu","MMP1101","","Lysine biosynthesis",5,"2.6.1.17","Amino acid metabolism","1,2"]
["R158","succinyl-diaminopimelate desuccinylase","s26dap + h2o -> succ + 26dap","MMP1398","dapE","Lysine biosynthesis",5,"3.5.1.18","Amino acid metabolism","1,2"]
["R159","LL-diaminopimelate aminotransferase","26dap + 2oxglu <=> tdpa + glu + h2o","MMP1527","","Lysine biosynthesis",5,"2.6.1.83","Amino acid metabolism","1,2"]
["R160","diaminopimelate epimerase","26dap <=> M26daP","MMP0917","dapF","Lysine biosynthesis",5,"5.1.1.7","Amino acid metabolism","1,2"]
["R161","diaminopimelate decarboxylase","M26daP -> lys + co2","MMP1200","lysA","Lysine biosynthesis",5,"4.1.1.20","Amino acid metabolism","1,2"]
["R162","Homoisocitrate hydro-lyase","hmisc <=> btc + h2o","(MMP0381 or MMP1480)","","Lysine biosynthesis",5,"4.2.1.36 4.2.1.114","Amino acid metabolism","1,2"]
["R163","lysine 2,3-aminomutase","lys -> 36dahx","MMP0861","kamA","Lysine biosynthesis",5,"5.4.3.2","Amino acid metabolism","1,2"]
["R164","dihydrodipicolinate reductase","tdpa + nad <=> 23dpa + nadh + h","MMP0923","dapB","Lysine biosynthesis",5,"1.3.1.26","Amino acid metabolism",9]
["R165","homocitrate synthase","accoa + h2o + 2oxglu -> hbtc + coa","MMP0153","aksA","Lysine biosynthesis",5,"2.3.3.14","Amino acid metabolism",15]
["R166","spermidine synthase","sama + spmd -> 5mta + spermn + h","MMP1584","","Arginine and proline metabolism",5,"2.5.1.16","Amino acid metabolism","1,2"]
["R167","ornithine carbamoyltransferase","cbp + orn <=> pi + citr","MMP0553","argF","Arginine and proline metabolism",5,"2.1.3.3","Amino acid metabolism","1,2"]
["R168","cytosine deaminase","crtn + h2o -> mhdt + nh3","MMP0869","","Arginine and proline metabolism",5,"3.5.4.1","Amino acid metabolism","1,2"]
["R169","arginine decarboxylase","arg -> agm + co2","MMP1582","pdaD","Arginine and proline metabolism",5,"4.1.1.19","Amino acid metabolism","1,2"]
["R170","amino-acid N-acetyltransferase","accoa + glu -> coa + aglu","MMP0897","argJ","Arginine and proline metabolism",5,"2.3.1.1","Amino acid metabolism","1,2"]
["R171","acetylglutamate kinase","atp + aglu -> adp + aglup","MMP0063","argB","Arginine and proline metabolism",5,"2.7.2.8","Amino acid metabolism","1,2"]
["R172","N-acetyl-gamma-glutamyl-phosphate reductase","aglup + nadph + h -> agsa + pi + nadp","MMP0116","argC","Arginine and proline metabolism",5,"1.2.1.38","Amino acid metabolism","1,2"]
["R173","acetylornithine transaminase","agsa + glu -> nacorn + 2oxglu","MMP1101","","Arginine and proline metabolism",5,"2.6.1.11","Amino acid metabolism","1,2"]
["R174","glutamate N-acetyltransferase","nacorn + glu <=> orn + aglu","MMP0897","argJ","Arginine and proline metabolism",5,"2.3.1.35","Amino acid metabolism","1,2"]
["R175","aspartate transaminase","e4hglu + 2oxglu -> hoxglu + glu","MMP1072","","Arginine and proline metabolism",5,"2.6.1.1","Amino acid metabolism","1,2"]
["R176","agmatinase","agm + h2o -> ptrc + urea","MMP1585","","Arginine and proline metabolism",5,"3.5.3.11","Amino acid metabolism","1,2"]
["R177","spermidine synthase","sama + ptrc -> 5mta + spmd + h","MMP1584",null,"Arginine and proline metabolism",5,"2.5.1.16","Amino acid metabolism","1,2"]
["R178","carbamate kinase","cbp + adp -> nh3 + co2 + atp","","","Arginine and proline metabolism",3,"2.7.2.2","Amino acid metabolism",3]
["R179","glutamate-5-kinase","orn -> pro + nh3","",null,"Arginine and proline metabolism",1,"4.3.1.12","Amino acid metabolism",6]
["R180","tyrosine aminotransferase","34hpp + glu -> 2oxglu + tyr","MMP0096",null,"tyrosine biosynthesis I",5,"2.6.1.57","Amino acid metabolism",3]
["R181","tyrosine decarboxylase","tyr -> tyrmn + co2","MMP0131","","Tyrosine metabolism",5,"4.1.1.25","Amino acid metabolism","1,2"]
["R182","aspartate transaminase","tyr + 2oxglu <=> 34hpp + glu","(MMP1072 and MMP1216)","hisC","Tyrosine metabolism",5,"2.6.1.1 2.6.1.9","Amino acid metabolism","1,2"]
["R183","tyrosine decarboxylase","dhphe -> dpmn + co2","MMP0131","","Tyrosine metabolism",5,"4.1.1.25","Amino acid metabolism","1,2"]
["R184","alcohol dehydrogenase","dhpeg + nad <=> dhma + nadh + h","MMP0802","","Tyrosine metabolism",5,"1.1.1.1","Amino acid metabolism","1,2"]
["R185","type 12 methyltransferase","Nmtyr + sam -> hrdn + sahc","MMP1717",null,"Tyrosine metabolism",5,"2.1.1.-","Amino acid metabolism","1,2"]
["R186","aspartate transaminase","phe + 2oxglu <=> ppyr + glu","(MMP1072 and MMP1216)","hisC","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"2.6.1.1 2.6.1.9","Amino acid metabolism","1,2"]
["R187","phenylacetate CoA ligase","atp + pac + coa <=> amp + ppi + phaccoa","(MMP0160 and MMP0314 and MMP0715)","ftsA-2","Phenylalanine metabolism",5,"6.2.1.30","Amino acid metabolism","1,2"]
["R188","3-Dehydroquinate hydro-lyase","3dhq <=> 3dsk + h2o","MMP1394","aroD","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.1.10","Amino acid metabolism","1,2"]
["R189","shikimate 5-dehydrogenase","skm + nadp <=> 3dsk + nadph + h","MMP0936","aroE","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"1.1.1.25","Amino acid metabolism","1,2"]
["R190","shikimate kinase","atp + skm -> adp + shk3p","MMP0320","","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"2.7.1.71","Amino acid metabolism","1,2"]
["R191","3-phosphoshikimate 1-carboxyvinyltransferase","pep + shk3p <=> pi + 5cpsk","MMP1205","aroA","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"2.5.1.19","Amino acid metabolism","1,2"]
["R192","chorismate synthase","5cpsk -> chrs + pi","MMP1333","aroC","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.3.5","Amino acid metabolism","1,2"]
["R193","anthranilate synthase","chrs + gln -> anth + pyr + glu","(MMP1005 and MMP1006)","(trpG and trpE)","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.1.3.27","Amino acid metabolism","1,2"]
["R194","anthranilate synthase","chrs + nh3 -> anth + pyr + h2o","(MMP1005 and MMP1006)","(trpG and trpE)","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.1.3.27","Amino acid metabolism","1,2"]
["R195","anthranilate phosphoribosyltransferase","npran + ppi <=> anth + prpp","MMP1007","trpD","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"2.4.2.18","Amino acid metabolism","1,2"]
["R196","phosphoribosylanthranilate isomerase","npran <=> cpad5p","MMP1004","trpF","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"5.3.1.24","Amino acid metabolism","1,2"]
["R197","indole-3-glycerol-phosphate synthase","cpad5p <=> igp + co2 + h2o","MMP1008","trpC","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.1.1.48","Amino acid metabolism","1,2"]
["R198","tryptophan synthase","ser + indole -> trp + h2o","MMP1003","trpB","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.1.20","Amino acid metabolism","1,2"]
["R199","indoleglycerolphosphatealdolase","igp <=> indole + g3p","MMP1002","trpA","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.1.20","Amino acid metabolism","1,2"]
["R200","chorismate mutase","chrs <=> prph","MMP0578","aroQ","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"5.4.99.5","Amino acid metabolism","1,2"]
["R201","prephenate dehydrogenase","prph + nad <=> 34hpp + co2 + nadh + h","MMP1514","tyrA","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"1.3.1.12","Amino acid metabolism","1,2"]
["R202","prephenate dehydratase","prph <=> ppyr + h2o + co2","MMP1528","pheA","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.1.51","Amino acid metabolism","1,2"]
["R203","prephenate dehydratase","agnt -> phe + h2o + co2","MMP1528","pheA","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.1.51","Amino acid metabolism","1,2"]
["R204","prephenate dehydrogenase","prph + nad -> 34hpp + co2 + nadh + h","MMP1514","tyrA","Phenylalanine, tyrosine and tryptophan biosynthesis",5,"1.3.1.12","Amino acid metabolism","1,2"]
["R205","2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase","asp4sa + dkfp -> addth + hpap_e","MMP0686",null,"Phenylalanine, tyrosine and tryptophan biosynthesis",5,"2.2.1.10","Amino acid metabolism","1,2"]
["R206","3-dehydroquinate synthase II","addth + h2o + nad -> 3dhq + nh3 + nadh + h","MMP0006",null,"Phenylalanine, tyrosine and tryptophan biosynthesis",5,"4.2.3.4 1.4.1.24","Amino acid metabolism",10]
["R207","6-deoxy-5-ketofructose 1-phosphate synthase","mglyx + f1p -> dkfp + glyald","MMP0293",null,"Phenylalanine, tyrosine and tryptophan biosynthesis",5,"2.2.1.11","Amino acid metabolism","1,2,4"]
["R208","urea out","asp + atp + nh3 -> ppi + amp + asn","MMP0918","asnB","asparagine biosynthesis II",5,"6.3.5.4","Amino acid metabolism",3]
["R209","aminoacyl-tRNA hydrolase","trnaasnyl + h2o -> asn + 2 h + trnaasn","MMP0609","pth2","asparagine biosynthesis III (tRNA-dependent)",3,"3.1.1.29","Amino acid metabolism",3]
["R210","adenine phosphoribosyltransferase\n","ade + prpp -> amp + ppi","(MMP0145 and MMP0660)","(hpt and apt)","Purine metabolism",5,"2.4.2.7","Nuclotide metabolism","1,2"]
["R211","adenine phosphoribosyltransferase","aicar + ppi <=> 5a4ic + prpp","(MMP0145 and MMP0660)","(hpt and apt)","Purine metabolism",5,"2.4.2.7","Nuclotide metabolism","1,2"]
["R212","adenine phosphoribosyltransferase","gmp + ppi <=> gua + prpp","(MMP0145 and MMP0660)","(hpt and apt)","Purine metabolism",5,"2.4.2.7","Nuclotide metabolism","1,2"]
["R213","5-(carboxyamino)imidazole ribonucleotide mutase","capri <=> cair","MMP0282","purE","Purine metabolism",5,"5.4.99.18 4.1.1.21","Nuclotide metabolism","1,2"]
["R214","nucleoside-triphosphate diphosphatase","ditp + h2o -> disnp + ppi","MMP0214",null,"Purine metabolism",5,"3.6.1.19","Nuclotide metabolism","1,2"]
["R215","IMP cyclohydrolase","imp + h2o <=> prfica","MMP1310","purO","Purine metabolism",5,"3.5.4.10","Nuclotide metabolism","1,2"]
["R216","nucleoside-triphosphate diphosphatase","itp + h2o <=> imp + ppi","MMP0214",null,"Purine metabolism",5,"3.6.1.19","Nuclotide metabolism","1,2"]
["R217","nucleoside-triphosphate diphosphatase","gtp + h2o -> gmp + ppi","MMP0214",null,"Purine metabolism",5,"3.6.1.19","Nuclotide metabolism","1,2"]
["R218","nucleoside-triphosphate diphosphatase","dgtp + h2o -> dgmp + ppi","MMP0214",null,"Purine metabolism",5,"3.6.1.19","Nuclotide metabolism","1,2"]
["R219","nucleoside-triphosphate diphosphatase","xtp + h2o -> xmp + ppi","MMP0214",null,"Purine metabolism",5,"3.6.1.19","Nuclotide metabolism","1,2"]
["R220","nucleoside-diphosphate kinase","atp + idp <=> adp + itp","MMP0283","ndk","Purine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R221","nucleoside-diphosphate kinase","atp + gdp <=> adp + gtp","MMP0283","ndk","Purine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R222","nucleoside-diphosphate kinase","atp + dgdp <=> adp + dgtp","MMP0283","ndk","Purine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R223","nucleoside-diphosphate kinase","atp + dadp <=> adp + datp","MMP0283","ndk","Purine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R224","nucleoside-diphosphate kinase","atp + didp <=> adp + ditp","MMP0283","ndk","Purine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R225","adenylosuccinate synthase","gtp + imp + asp -> gdp + pi + dcamp","MMP1432","purA","Purine metabolism",5,"6.3.4.4","Nuclotide metabolism","1,2"]
["R226","adenylosuccinate lyase","dcamp -> fum + amp","MMP0971","purB","Purine metabolism",5,"4.3.2.2","Nuclotide metabolism","1,2"]
["R227","adenylate cyclase","atp -> camp + ppi","(MMP0128 or MMP1064)",null,"Purine metabolism",5,"4.6.1.1","Nuclotide metabolism","1,2"]
["R228","adenylate cyclase","gtp -> cgmp + ppi","(MMP0128 or MMP1064)","","Purine metabolism",5,"4.6.1.1","Nuclotide metabolism","1,2"]
["R229","phosphoribosylamine---glycine ligase","atp + pram + gly -> adp + pi + gar","MMP0392","purD","Purine metabolism",5,"6.3.4.13","Nuclotide metabolism","1,2"]
["R230","pyruvate kinase","gtp + pyr <=> gdp + pep","MMP1605","","Purine metabolism",5,"2.7.1.40","Nuclotide metabolism","1,2"]
["R231","pyruvate kinase","dgdp + pep -> dgtp + pyr","MMP1605","","Purine metabolism",5,"2.7.1.40","Nuclotide metabolism","1,2"]
["R232","pyruvate kinase","datp + pyr <=> dadp + pep","MMP1605","","Purine metabolism",5,"2.7.1.40","Nuclotide metabolism","1,2"]
["R233","ribonucleoside-triphosphate reductase","gtp + rthio -> dgtp + thrds + h2o","MMP0227","nrdD","Purine metabolism",5,"1.17.4.2","Nuclotide metabolism","1,2"]
["R234","5'-nucleotidase","dgmp + h2o <=> dg + pi","MMP1051","surE","Purine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R235","phosphoribosylglycinamide formyltransferase","fthf + gar <=> thf + fgar","MMP0123","purT","Purine metabolism",5,"2.1.2.2","Nuclotide metabolism","1,2"]
["R236","5'-nucleotidase","gmp + h2o -> gsn + pi","MMP1051","surE","Purine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R237","5'-nucleotidase","xmp + h2o -> xtsn + pi","MMP1051","surE","Purine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R238","5'-nucleotidase","imp + h2o -> insn + pi","MMP1051","surE","Purine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R239","5'-nucleotidase","amp + h2o -> adn + pi","MMP1051","surE","Purine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R240","5'-nucleotidase","damp + h2o <=> dadsn + pi","MMP1051","surE","Purine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R241","GMP synthase (glutamine-hydrolysing)","atp + xmp + gln + h2o -> amp + ppi + gmp + glu","(MMP0894 and MMP1445)","guaA","Purine metabolism",5,"6.3.5.2","Nuclotide metabolism","1,2"]
["R242","IMP dehydrogenase","imp + nad + h2o -> xmp + nadh + h","(MMP0133 and MMP0287)","guaB","Purine metabolism",5,"1.1.1.205","Nuclotide metabolism","1,2"]
["R243","adenylate kinase","atp + amp <=> 2 adp","MMP1031","adkA","Purine metabolism",5,"2.7.4.3","Nuclotide metabolism","1,2"]
["R244","ribonucleoside-triphosphate reductase","atp + rthio -> datp + thrds + h2o","MMP0227","nrdD","Purine metabolism",5,"1.17.4.2","Nuclotide metabolism","1,2"]
["R245","phosphoribosylformylglycinamidine synthase","atp + fgar + gln + h2o -> adp + pi + fgam + glu","(MMP0178 and MMP0179)","(purQ and purL)","Purine metabolism",5,"6.3.5.3","Nuclotide metabolism","1,2"]
["R246","phosphoribosylformylglycinamidine cyclo-ligase","atp + fgam -> adp + pi + air","(MMP0882 or MMP1254)","purM","Purine metabolism",5,"6.3.3.1","Nuclotide metabolism","1,2"]
["R247","phosphoribosylaminoimidazolesuccinocarboxamide synthase","atp + cair + asp <=> adp + pi + saicar","MMP0540","purC","Purine metabolism",5,"6.3.2.6","Nuclotide metabolism","1,2"]
["R248","adenylosuccinate lyase","saicar <=> fum + aicar","MMP0971","purB","Purine metabolism",5,"4.3.2.2","Nuclotide metabolism","1,2"]
["R249","5-(carboxyamino)imidazole ribonucleotide synthase","atp + hco3 + air + h -> adp + pi + capri","",null,"Purine metabolism",3,"6.3.4.18","Nuclotide metabolism","1,2"]
["R250","5-(carboxyamino)imidazole ribonucleotide mutase","formate + atp + aicar -> prfica + adp + pi","MMP1373","purP","Purine metabolism",5,"6.3.4.-","Nuclotide metabolism","1,2"]
["R251","guanylate kinase","gdp + adp <=> atp + gmp","",null,"Purine metabolism",1,"2.7.4.8","Nuclotide metabolism",7]
["R252","ATPase","atp + h2o -> adp + pi","(MMP0024 and MMP0281 and MMP0214)",null,"Purine metabolism",5,"3.6.3.- 3.6.1.15","Nuclotide metabolism","1,2"]
["R253","translation-associated GTPase","gtp + h2o -> gdp + pi","MMP1122","ychF","Purine metabolism",5,"3.6.5.3","Nuclotide metabolism","1,2"]
["R254","nucleoside triphosphatase","tpp + h2o <=> ppi + pi","MMP0339",null,"Purine metabolism",5,"3.6.1.25","Nuclotide metabolism","1,2"]
["R255","aspartate carbamoyltransferase","cbp + asp -> pi + cbasp","(MMP1104 and MMP1659)","(pyrI and pyrB)","Pyrimidine metabolism",5,"2.1.3.2","Nuclotide metabolism","1,2"]
["R256","dCTP deaminase","ctp + h2o <=> utp + nh3","MMP1426","dcd","Pyrimidine metabolism",5,"3.5.4.13","Nuclotide metabolism","1,2"]
["R257","CTP synthase","atp + utp + nh3 -> adp + pi + ctp","MMP0893","pyrG","Pyrimidine metabolism",5,"6.3.4.2","Nuclotide metabolism","1,2"]
["R258","CTP synthase","atp + utp + gln + h2o -> adp + pi + ctp + glu","MMP0893","pyrG","Pyrimidine metabolism",5,"6.3.4.2","Nuclotide metabolism","1,2"]
["R259","dCTP deaminase","dctp + h2o -> dutp + nh3","MMP1426","dcd","Pyrimidine metabolism",5,"3.5.4.13","Nuclotide metabolism","1,2"]
["R260","orotate phosphoribosyltransferase","orot5p + ppi <=> orot + prpp","(MMP0079 and MMP1492)","pyrE","Pyrimidine metabolism",5,"2.4.2.10","Nuclotide metabolism","1,2"]
["R261","nucleoside-diphosphate kinase","atp + udp <=> adp + utp","MMP0283","ndk","Pyrimidine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R262","nucleoside-diphosphate kinase","atp + cdp <=> adp + ctp","MMP0283","ndk","Pyrimidine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R263","carbamoyl-phosphate synthase (glutamine-hydrolysing)","2 atp + gln + hco3 + h2o <=> 2 adp + pi + glu + cbp","(MMP1013 and MMP1589)","(carA and carB)","Pyrimidine metabolism",5,"6.3.5.5","Nuclotide metabolism","1,2"]
["R264","nucleoside-diphosphate kinase","atp + dcdp <=> adp + dctp","MMP0283","ndk","Pyrimidine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R265","nucleoside-diphosphate kinase","atp + dudp <=> adp + dutp","MMP0283","ndk","Pyrimidine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R266","nucleoside-diphosphate kinase","atp + dtdp <=> adp + dttp","MMP0283","ndk","Pyrimidine metabolism",5,"2.7.4.6","Nuclotide metabolism","1,2"]
["R267","nucleoside-triphosphate diphosphatase","utp + h2o -> ump + ppi","MMP0214","","Pyrimidine metabolism",5,"3.6.1.19","Nuclotide metabolism","1,2"]
["R268","dUTP diphosphatase","dutp + h2o -> dump + ppi","(MMP0214 or MMP1075)","dut","Pyrimidine metabolism",5,"3.6.1.19 3.6.1.23","Nuclotide metabolism","1,2"]
["R269","orotidine-5'-phosphate decarboxylase","orot5p -> ump + co2","MMP0602","pyrF","Pyrimidine metabolism",5,"4.1.1.23","Nuclotide metabolism","1,2"]
["R270","UMP/CMP kinase","atp + cmp <=> adp + cdp","MMP0626","cmk","Pyrimidine metabolism",5,"2.7.4.14","Nuclotide metabolism","1,2"]
["R271","UMP/CMP kinase","atp + dcmp <=> adp + dcdp","MMP0626","cmk","Pyrimidine metabolism",5,"2.7.4.14","Nuclotide metabolism","1,2"]
["R272","UMP/CMP kinase","atp + ump <=> adp + udp","(MMP0385 and MMP0626)","pyrH","Pyrimidine metabolism",5,"2.7.4.22","Nuclotide metabolism","1,2"]
["R273","thioredoxin-disulfide reductase","thrds + nadph + h -> rthio + nadp","MMP0959","trxB","Pyrimidine metabolism",5,"1.8.1.9","Nuclotide metabolism","1,2"]
["R274","dTMP kinase","atp + dtmp <=> adp + dtdp","MMP1034","tmk","Pyrimidine metabolism",5,"2.7.4.9","Nuclotide metabolism","1,2"]
["R275","dTMP kinase","atp + dump <=> adp + dudp","MMP1034","tmk","Pyrimidine metabolism",5,"2.7.4.9","Nuclotide metabolism","1,2"]
["R276","thymidylate synthase","dump + mlthf -> dhf + dtmp","(MMP0986 and MMP1379)","thyA","Pyrimidine metabolism",5,"2.1.1.45","Nuclotide metabolism","1,2"]
["R277","5'-nucleotidase","ump + h2o -> uri + pi","MMP1051","surE","Pyrimidine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R278","5'-nucleotidase","cmp + h2o -> cytdn + pi","MMP1051","surE","Pyrimidine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R279","5'-nucleotidase","dcmp + h2o -> dc + pi","MMP1051","surE","Pyrimidine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R280","5'-nucleotidase","dtmp + h2o -> thymd + pi","MMP1051","surE","Pyrimidine metabolism",5,"3.1.3.5 3.1.3.2","Nuclotide metabolism","1,2"]
["R281","uracil phosphoribosyltransferase","ump + ppi <=> ura + prpp","MMP0680","upp","Pyrimidine metabolism",5,"2.4.2.9","Nuclotide metabolism","1,2"]
["R282","thymidine phosphorylase","thymd + pi -> thym + 2dr1p","MMP0327","deoA","Pyrimidine metabolism",5,"2.4.2.4","Nuclotide metabolism","1,2"]
["R283","thymidine phosphorylase","duri + pi -> ura + 2dr1p","MMP0327","deoA","Pyrimidine metabolism",5,"2.4.2.4","Nuclotide metabolism","1,2"]
["R284","cytosine deaminase","csn + h2o -> ura + nh3","MMP0869","","Pyrimidine metabolism",5,"3.5.4.1","Nuclotide metabolism","1,2"]
["R285","cytosine deaminase","mcsn + h2o <=> thym + nh3","MMP0869","","Pyrimidine metabolism",5,"3.5.4.1","Nuclotide metabolism","1,2"]
["R286","dihydroorotase","doroa + h2o <=> cbasp","MMP1009","pyrC","Pyrimidine metabolism",5,"3.5.2.3","Nuclotide metabolism","1,2"]
["R287","ribonucleoside-triphosphate reductase","utp + rthio -> dutp + thrds + h2o","MMP0227","nrdD","Pyrimidine metabolism",5,"1.17.4.2","Nuclotide metabolism","1,2"]
["R288","dihydroorotate dehydrogenase (fumarate)","doroa + fum <=> orot + succ","MMP0439","pyrD","Pyrimidine metabolism",5,"1.3.98.1 1.3.3.1","Nuclotide metabolism","1,2"]
["R289","ribonucleoside-triphosphate reductase","ctp + rthio -> dctp + thrds + h2o","MMP0227","nrdD","Pyrimidine metabolism",5,"1.17.4.2","Nuclotide metabolism","1,2"]
["R290","deoxycytidylate kinase","atp + cmp -> adp + cdp","","","salvage pathways of pyrimidine ribonucleotides",3,"2.7.4.25","Nuclotide metabolism",3]
["R291","uridine kinase","cytdn + gtp -> cmp + gdp","","","salvage pathways of pyrimidine ribonucleotides",3,"2.7.1.48","Nuclotide metabolism",3]
["R292","GTP cyclohydrolase Iia","gtp + 3 h2o -> afapdrp + 2 pi","MMP0405","gch3","Riboflavin metabolism",5,"3.5.4.29","Metabolism of cofactors and vitamins","1,2"]
["R293","2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase","afapdrp + h2o -> daprap + formate","MMP1705",null,"Riboflavin metabolism",5,"3.5.1.102","Metabolism of cofactors and vitamins","1,2"]
["R294","2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase","daprap + nadh + h -> 25adrpn + nad","MMP1348","","Riboflavin metabolism",5,"1.1.1.302","Metabolism of cofactors and vitamins","1,2"]
["R295","2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase","daprap + nadph + h -> 25adrpn + nadp","MMP1348","","Riboflavin metabolism",5,"1.1.1.302","Metabolism of cofactors and vitamins","1,2"]
["R296","FMN reductase (NADH)","fmnh2 + nad <=> fmn + h + nadh","MMP1259",null,"flavin biosynthesis II (archaea)",5,"1.6.99.3","Metabolism of cofactors and vitamins","1,2"]
["R297","threonine synthase","pht + h2o -> 4hlt + pi","MMP0135","\n\n\nthrC","Vitamin B6 metabolism",5,"4.2.3.1","Metabolism of cofactors and vitamins","1,2"]
["R298","acetolactate synthase","2 pyr -> aclact + co2","MMP0650","ilvB","Pantothenate and CoA biosynthesis",5,"2.2.1.6","Metabolism of cofactors and vitamins","1,2"]
["R299","ketol-acid reductoisomerase","aclact + nadph + h -> dhmbn + nadp","MMP0654","ilvC","Pantothenate and CoA biosynthesis",5,"1.1.1.86","Metabolism of cofactors and vitamins","1,2"]
["R300","dihydroxy-acid dehydratase","dhmbn -> 2oival + h2o","MMP0318","ilvD","Pantothenate and CoA biosynthesis",5,"4.2.1.9","Metabolism of cofactors and vitamins","1,2"]
["R301","2-dehydropantoate 2-reductase","pant-R + nadp <=> 2dhp + nadph + h","MMP0672","","Pantothenate and CoA biosynthesis",5,"1.1.1.169","Metabolism of cofactors and vitamins","1,2"]
["R302","pantoate kinase","atp + pant-R -> adp + pptn","MMP0398","","Pantothenate and CoA biosynthesis",5,"2.7.1.169","Metabolism of cofactors and vitamins","1,2"]
["R303","4-phosphopantoate---beta-alanine ligase","atp + pptn + ala -> amp + ppi + 4ppan","MMP1306",null,"Pantothenate and CoA biosynthesis",5,"6.3.2.36","Metabolism of cofactors and vitamins","1,2"]
["R304","phosphopantothenate---cysteine ligase","ctp + 4ppan + cys -> cmp + ppi + 4ppncys","MMP1606","","Pantothenate and CoA biosynthesis",5,"6.3.2.5","Metabolism of cofactors and vitamins","1,2"]
["R305","phosphopantothenate---cysteine ligase","atp + 4ppan + cys -> amp + ppi + 4ppncys","MMP1606","","Pantothenate and CoA biosynthesis",5,"6.3.2.5","Metabolism of cofactors and vitamins","1,2"]
["R306","phosphopantothenoylcysteine decarboxylase","4ppncys -> pan4p + co2","MMP1606","","Pantothenate and CoA biosynthesis",5,"4.1.1.36","Metabolism of cofactors and vitamins","1,2"]
["R307","pantetheine-phosphate adenylyltransferase","atp + pan4p <=> ppi + dpcoa","MMP1093","coaD","Pantothenate and CoA biosynthesis",5,"2.7.7.3","Metabolism of cofactors and vitamins","1,2"]
["R308","6-carboxyhexanoate---CoA ligase","atp + pim + coa -> amp + ppi + pmcoa","MMP1575","bioW","Biotin metabolism",5,"6.2.1.14","Metabolism of cofactors and vitamins","1,2"]
["R309","8-amino-7-oxononanoate synthase","pmcoa + ala -> 8aonn + coa + co2","MMP1574","bioF","Biotin metabolism",5,"2.3.1.47","Metabolism of cofactors and vitamins","1,2"]
["R310","adenosylmethionine---8-amino-7-oxononanoate transaminase","sam + 8aonn <=> amob + dann","MMP0865",null,"Biotin metabolism",5,"2.6.1.62","Metabolism of cofactors and vitamins","1,2"]
["R311","dethiobiotin synthase","atp + dann + co2 -> adp + pi + dtbt","MMP1573","\n\n\nbioD","Biotin metabolism",5,"6.3.3.3","Metabolism of cofactors and vitamins","1,2"]
["R312","biotin synthase","dtbt + 2 sam + h2s + 2 electron <=> btn + 2 met + 2 dasn","(MMP0126 or MMP1238)","bioB","Biotin metabolism",5,"2.8.1.6","Metabolism of cofactors and vitamins","1,2"]
["R313","biotin---[acetyl-CoA-carboxylase] ligase","atp + btn -> ppi + btamp","MMP0119","birA","Biotin metabolism",5,"6.3.4.15","Metabolism of cofactors and vitamins","1,2"]
["R314","biotin---[acetyl-CoA-carboxylase] ligase","btamp + apoc <=> amp + hcarb","MMP0119","birA","Biotin metabolism",5,"6.3.4.15","Metabolism of cofactors and vitamins","1,2"]
["R315","6-pyruvoyltetrahydropterin synthase","ahdt -> pythp + tpp","MMP1250","","Folate biosynthesis",5,"4.2.3.12","Metabolism of cofactors and vitamins","1,2"]
["R316","uroporphyrinogen decarboxylase","uppg1 -> copp1 + 4 co2","(MMP0830 or MMP1150)","mtaA","Porphyrin and chlorophyll metabolism",5,"4.1.1.37","Metabolism of cofactors and vitamins","1,2"]
["R317","ferroxidase","oxygen + 4 fe2 + 4 h -> 4 fe3 + 2 h2o","MMP1159","","Porphyrin and chlorophyll metabolism",5,"1.16.3.1","Metabolism of cofactors and vitamins","1,2"]
["R318","porphobilinogen synthase","2 5alev -> ppbng + 2 h2o","MMP1258","hemB","Porphyrin and chlorophyll metabolism",5,"4.2.1.24","Metabolism of cofactors and vitamins","1,2"]
["R319","hydroxymethylbilane synthase","4 ppbng + h2o -> hmbil + 4 nh3","MMP0872","hemC","Porphyrin and chlorophyll metabolism",5,"2.5.1.61","Metabolism of cofactors and vitamins","1,2"]
["R320","uroporphyrinogen-III synthase","hmbil -> uppg3 + h2o","MMP0394","hemD","Porphyrin and chlorophyll metabolism",5,"4.2.1.75","Metabolism of cofactors and vitamins","1,2"]
["R321","uroporphyrinogen decarboxylase","uppg3 -> cpp + 4 co2","(MMP0830 or MMP1150)","mtaA","Porphyrin and chlorophyll metabolism",5,"4.1.1.37","Metabolism of cofactors and vitamins","1,2"]
["R322","uroporphyrinogen-III C-methyltransferase","2 sam + uppg3 -> 2 sahc + pc2","MMP0966","cobA","Porphyrin and chlorophyll metabolism",5,"2.1.1.107","Metabolism of cofactors and vitamins","1,2"]
["R323","glutamate---tRNA ligase","trnaglu + glu + atp <=> glutrna + ppi + amp","MMP1011","gltX","Porphyrin and chlorophyll metabolism",5,"6.1.1.17","Metabolism of cofactors and vitamins","1,2"]
["R324","glutamyl-tRNA reductase","glutrna + nadph + h -> aoxp + trnaglu + nadp","MMP0088","hemA","Porphyrin and chlorophyll metabolism",5,"1.2.1.70","Metabolism of cofactors and vitamins","1,2"]
["R325","glutamate-1-semialdehyde 2,1-aminomutase","aoxp -> 5alev","MMP0224","hemL","Porphyrin and chlorophyll metabolism",5,"5.4.3.8","Metabolism of cofactors and vitamins","1,2"]
["R326","precorrin-2 dehydrogenase","pc2 + nad -> scl + nadh + h","MMP0089","","Porphyrin and chlorophyll metabolism",5,"1.3.1.76","Metabolism of cofactors and vitamins","1,2"]
["R327","sirohydrochlorin ferrochelatase","fe2 + scl -> sheme + 2 h","MMP0089","","Porphyrin and chlorophyll metabolism",5,"4.99.1.4","Metabolism of cofactors and vitamins","1,2"]
["R328","sirohydrochlorin cobaltochelatase","co+2 + scl -> 2 h + coshrdn","MMP0164","cbiXs","Porphyrin and chlorophyll metabolism",5,"4.99.1.3","Metabolism of cofactors and vitamins","1,2"]
["R329","cobalt-factor II C20-methyltransferase","sam + coshrdn -> sahc + cof3","MMP0319","cbiL","Porphyrin and chlorophyll metabolism",5,"2.1.1.151","Metabolism of cofactors and vitamins","1,2"]
["R330","3,4-dihydroxy-2-butanone-4-phosphate synthase","ru5p -> db4p + formate","MMP0183","ribB","Riboflavin metabolism",5,"4.1.99.12","Metabolism of cofactors and vitamins","1,2"]
["R331","precorrin-3B C17-methyltransferase","copre3 + sam -> copre4 + sahc","MMP0953","cbiH","Porphyrin and chlorophyll metabolism",5,"2.1.1.131","Metabolism of cofactors and vitamins","1,2"]
["R332","precorrin-4 C11-methyltransferase","copre4 + sam -> copre5a + sahc","MMP1662","cbiF","Porphyrin and chlorophyll metabolism",5,"2.1.1.133","Metabolism of cofactors and vitamins","1,2"]
["R333","cobalt-precorrin 5A hydrolase","copre5a + h2o -> copre5b + acald","MMP1591","cbiG","Porphyrin and chlorophyll metabolism",5,"3.7.1.12","Metabolism of cofactors and vitamins","1,2"]
["R334","cobalt-precorrin-5B (C1)-methyltransferase","copre5b + sam + h -> sahc + copre6","MMP1203","cbiD","Porphyrin and chlorophyll metabolism",5,"2.1.1.195","Metabolism of cofactors and vitamins","1,2"]
["R335","precorrin-6A reductase","copre6 + nadph + h -> codhpre6 + nadp","MMP0599","cbiJ","Porphyrin and chlorophyll metabolism",5,"1.3.1.54","Metabolism of cofactors and vitamins","1,2"]
["R336","precorrin-6Y C5,15-methyltransferase (decarboxylating)","codhpre6 + sam -> copre7 + sahc","MMP1227","cbiE","Porphyrin and chlorophyll metabolism",5,"2.1.1.132","Metabolism of cofactors and vitamins","1,2"]
["R337","cobalt-precorrin-7 (C15)-methyltransferase [decarboxylating]","copre7 + sam -> copre8 + sahc + co2","MMP1221","CbiT","Porphyrin and chlorophyll metabolism",5,"2.1.1.196","Metabolism of cofactors and vitamins","1,2"]
["R338","precorrin-8X methylmutase","copre8 -> cobya","MMP0330","cbiC","Porphyrin and chlorophyll metabolism",5,"5.4.1.2","Metabolism of cofactors and vitamins","1,2"]
["R339","cobyrinate a,c-diamide synthase","cobya + 2 gln + 2 atp + 2 h2o -> co2dam + 2 glu + 2 adp + 2 pi","(MMP1477 or MMP1478 or MMP0028)","CbiA","Porphyrin and chlorophyll metabolism",5,"6.3.5.11","Metabolism of cofactors and vitamins","1,2"]
["R340","precorrin-2 C20-methyltransferase","sam + pc2 -> sahc + pre3a + h","MMP0319","cbiL","Porphyrin and chlorophyll metabolism",5,"2.1.1.130","Metabolism of cofactors and vitamins","1,2"]
["R341","6,7-dimethyl-8-ribityllumazine synthase","aribau + db4p -> dmlz + 2 h2o + pi","MMP0050","ribH","Riboflavin metabolism",5,"2.5.1.78","Metabolism of cofactors and vitamins","1,2"]
["R342","precorrin-3B C17-methyltransferase","sam + pre3b -> sahc + pre4","MMP0953","cbiH","Porphyrin and chlorophyll metabolism",5,"2.1.1.131","Metabolism of cofactors and vitamins","1,2"]
["R343","precorrin-4 C11-methyltransferase","sam + pre4 -> sahc + pre5","MMP1662","cbiF","Porphyrin and chlorophyll metabolism",5,"2.1.1.133","Metabolism of cofactors and vitamins","1,2"]
["R344","precorrin-6A reductase","pre6a + nadph + h -> pre6b + nadp","MMP0599","cbiJ","Porphyrin and chlorophyll metabolism",5,"1.3.1.54","Metabolism of cofactors and vitamins","1,2"]
["R345","hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)","hybyr + 2 gln + 2 atp + 2 h2o -> hgbam + 2 pi + 2 glu + 2 adp","(MMP1477 or MMP1478)","cbiA","Porphyrin and chlorophyll metabolism",5,"6.3.5.9","Metabolism of cofactors and vitamins","1,2"]
["R346","cobaltochelatase","hgbam + co+2 + atp + h2o -> co2dam + pi + adp + h","MMP0493","CobN","Porphyrin and chlorophyll metabolism",5,"6.6.1.2","Metabolism of cofactors and vitamins","1,2"]
["R347","adenosylcobyric acid synthase (glutamine-hydrolysing)","acobda + 4 gln + 4 atp + 4 h2o -> acobh + 4 glu + 4 pi + 4 adp","MMP1215",null,"Porphyrin and chlorophyll metabolism",5,"6.3.5.10","Metabolism of cofactors and vitamins","1,2"]
["R348","adenosylcobinamide-phosphate synthase","atp + acobh + apol <=> adp + pi + adocbi","MMP1215",null,"Porphyrin and chlorophyll metabolism",5,"6.3.1.10","Metabolism of cofactors and vitamins","1,2"]
["R349","adenosylcobinamide-phosphate synthase","acobh + applp + atp -> adocbip + adp + pi","MMP1215",null,"Porphyrin and chlorophyll metabolism",5,"6.3.1.10","Metabolism of cofactors and vitamins","1,2"]
["R350","adenosylcobinamide-GDP ribazoletransferase","agdpcbi + rbz -> VitB12 + gmp","MMP0938","cobS","Porphyrin and chlorophyll metabolism",5,"2.7.8.26","Metabolism of cofactors and vitamins","1,2"]
["R351","riboflavin synthase","2 dmlz -> ribflv + aribau","(MMP0050 and MMP0180)","ribH and ribC","Riboflavin metabolism",5,"2.5.1.9","Metabolism of cofactors and vitamins","1,2"]
["R352","CTP-dependent riboflavin kinase","ctp + ribflv -> cdp + fmn","MMP0184",null,"Riboflavin metabolism",5,"2.7.1.161","Metabolism of cofactors and vitamins","1,2"]
["R353","ribose check","sald + cys -> smtc + h2o + 2 h","",null,"coenzyme M biosynthesis I",3,"no EC number assigned","Metabolism of cofactors and vitamins",3]
["R354","COM biosynthesis I","nadh + h + smtc -> 2secys + nad","",null,"coenzyme M biosynthesis I",3,"no EC number assigned","Metabolism of cofactors and vitamins",3]
["R355","coenzyme M biosynthesis I","2secys + h2o + h -> nh3 + pyr + COM","",null,"coenzyme M biosynthesis I",3,"no EC number assigned","Metabolism of cofactors and vitamins",3]
["R356","tetrahydromethanopterin biosynthesis","3dhq + 2 h + nh3 -> 4 h2o + 4abz","",null,"tetrahydromethanopterin biosynthesis",3,"no EC number assigned","Metabolism of cofactors and vitamins",3]
["R357","beta-ribofuranosylaminobenzene 5'-phosphate synthase","4abz + prpp -> rfab + co2 + ppi + h","MMP0279","mptG","tetrahydromethanopterin biosynthesis",5,"2.4.2.54","Metabolism of cofactors and vitamins",3]
["R358","purine-nucleoside phosphorylase","adn + pi -> ade + r1p","",null,"adenine and adenosine salvage I",3,"2.4.2.1","Metabolism of cofactors and vitamins",3]
["R359","dephospho-CoA kinase","dpcoa + atp -> adp + coa","","","coenzyme A biosynthesis",3,"2.7.1.24","Metabolism of cofactors and vitamins",3]
["R360","F420-non-reducing hydrogenase","mthp + h2 -> dhmtpz","(MMP1694 and MMP1692 and MMP1696 and MMP1695 and MMP1693)","(vhuA and vhuB and vhuD and vhuG and vhuU)","coenzyme B/coenzyme M regeneration",5,"1.12.98.3","Metabolism of cofactors and vitamins",3]
["R361","2-phospho-L-lactate synthase","s-lac + gtp -> 2plac + gdp","",null,"factor 420 biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R362","FAD synthetase","fmn + atp -> ppi + fad","MMP0943","taqD","flavin biosynthesis II (archaea)",5,"2.7.7.39","Metabolism of cofactors and vitamins",3]
["R363","pyrimidine phosphatase","5aprau + h2o -> aribau + pi","",null,"flavin biosynthesis II (archaea)",3,"3.1.3.-","Metabolism of cofactors and vitamins",3]
["R364","nicotinate-nucleotide---dimethylbenzimidazole phosphoribosyltransferase","nmn + dmbz -> pardb + h + nic","","","adenosylcobalamin biosynthesis I (early cobalt insertion)",3,"2.4.2.21","Metabolism of cofactors and vitamins",3]
["R365","phosphatidylglycerophosphatase A ","pardb + h2o -> rbz + pi","MMP1597","","adenosylcobalamin biosynthesis II (late cobalt incorporation)",5,"3.1.3.73","Metabolism of cofactors and vitamins",3]
["R366","cob(II)yrinic acid a,c-diamide reductase","2 co2dam + fmnh2 -> 2 co1dam + fmn + 2 h","","","adenosylcobalamin biosynthesis I (early cobalt insertion)",3,"1.16.8.1","Metabolism of cofactors and vitamins",3]
["R367","cob(I)yrinic acid a,c-diamide adenosyltransferase","co1dam + atp <=> acobda + tpp","",null,"adenosylcobalamin biosynthesis I (early cobalt insertion)",3,"2.5.1.17","Metabolism of cofactors and vitamins",3]
["R368","adenosylcobinamide-phosphate guanylyltransferase","adocbip + gtp -> agdpcbi + ppi","",null,"adenosylcobalamin biosynthesis I (early cobalt insertion)",3,"2.7.7.62","Metabolism of cofactors and vitamins",3]
["R369","flavin biosynthesis II (archaea)","25adrpn + h2o -> 5aprau + nh3","",null,"flavin biosynthesis II (archaea)",3,"3.5.4.-","Metabolism of cofactors and vitamins",3]
["R370","pyridoxal 5'-phosphate synthase (glutamine hydrolyzing","r5p + g3p + gln <=> glu + 3 h2o + pi + pyr5p","(MMP0103 or MMP1656)","PdxS","pyridoxal 5'-phosphate biosynthesis II",5,"4.3.3.6","Metabolism of cofactors and vitamins",3]
["R371","ribonucleoside-diphosphate reductase","dadp + thrds + h2o -> rthio + adp","",null,"adenosine nucleotides de novo biosynthesis",3,"1.17.4.1","Metabolism of cofactors and vitamins",3]
["R372","cobalt-precorrin 3 dehydrogenase","cof3 + 2 h <=> copre3","",null,"Porphyrin and chlorophyll metabolism",3,null,"Metabolism of cofactors and vitamins","1,2"]
["R373","Enzyme unknown","pc2 + ni2 + 2 gln + 3 h -> cof430 + 2 glu + h2o","",null,"Porphyrin and chlorophyll metabolism",2,null,"Metabolism of cofactors and vitamins","1,2"]
["R374","Isopropylmalate/isohomocitrate dehydrogenase","nad + 1hydtc <=> 2oxsub + co2 + nadh + h","MMP0880","aksF","coenzyme B biosynthesis",4,"1.1.1.-","Metabolism of cofactors and vitamins",18]
["R375","Enzyme unknown","2oxsub -> 7oxhep + co2","",null,"coenzyme B biosynthesis",4,null,"Metabolism of cofactors and vitamins",18]
["R376","Enzyme unknown","7mrhpt + thr + atp -> 7merhthr + adp + pi","",null,"coenzyme B biosynthesis",4,null,"Metabolism of cofactors and vitamins",18]
["R377","Enzyme unknown","7oxhep + 2 h + h2s -> 7mrhpt + h2o","",null,"coenzyme B biosynthesis",4,null,"Metabolism of cofactors and vitamins",18]
["R378","Enzyme unknown","7merhthr + atp -> cob + adp","",null,"coenzyme B biosynthesis",4,null,"Metabolism of cofactors and vitamins",18]
["R379","8-amino-7-oxononanoate synthase","Pimeloylacp + ala <=> 8aonn + ACP + co2","MMP1574","bioF","Biotin metabolism",5,"2.3.1.47","Metabolism of cofactors and vitamins","1,2"]
["R380","GTP cyclohydrolase","gtp + h2o -> 78dnpt3p + formate","MMP0034",null,"tetrahydromethanopterin biosynthesis",5,"3.5.4.16","Metabolism of cofactors and vitamins","1,2"]
["R381","metal dependent phosphohydrolase","78dnpt3p + h2o -> dnptp + ppi","(MMP0037 or MMP0230)",null,"tetrahydromethanopterin biosynthesis",5,"3.6.1.-","Metabolism of cofactors and vitamins","1,2"]
["R382","metal dependent phosphohydrolase","dnptp + h2o -> dnpt + pi","(MMP0037 or MMP0230)",null,"tetrahydromethanopterin biosynthesis",5,"3.6.1.-","Metabolism of cofactors and vitamins","1,2"]
["R383","dihydroneopterin aldolase","dnpt -> Glycald + 2a4h78dnpt","",null,"tetrahydromethanopterin biosynthesis",3,"4.1.2.25","Metabolism of cofactors and vitamins",3]
["R384","dihydropteroate synthase","rfab + 2a4h78dnpt -> 78hptab5p + ppi + 2 h","MMP1580",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R385","THMPT synthesis 6","78hptab5p + 2 h -> 78dptr5p","",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R386","THMPT synthesis 7","78dptr5p + h2o -> 78dptapr + pi","",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R387","THMPT synthesis 8","78dptapr + prpp -> 78dptf5p + ppi","",null,"tetrahydromethanopterin biosynthesis",3,"2.4.2.-","Metabolism of cofactors and vitamins",3]
["R388","THMPT synthesis 9","78dptf5p + atp -> 78dptftp + amp","",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R389","THMPT synthesis 10","78dptftp + 2hydoxglu -> dm78dhmpt + ppi","",null,"tetrahydromethanopterin biosynthesis",3,"1.1.99.2","Metabolism of cofactors and vitamins",3]
["R390","THMPT synthesis 11","2hydoxglu + fad <=> 2oxglu + fadh2","",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R391","THMPT synthesis 12","dm78dhmpt + 2 sam -> dhmpt + 2 sahc","",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R392","THMPT synthesis 13","dhmpt + h + nadph -> thmpt + nadp","",null,"tetrahydromethanopterin biosynthesis",3,null,"Metabolism of cofactors and vitamins",3]
["R393","Threonine kinase","thr + atp -> adp + thr3p","","PduX","Porphyrin and chlorophyll metabolism",3,"2.7.1.177","Metabolism of cofactors and vitamins",3]
["R394","threonine-phosphate decarboxylase","thr3p -> applp + co2","",null,"Porphyrin and chlorophyll metabolism",3,"4.1.1.81","Metabolism of cofactors and vitamins",3]
["R395","cyclic pyranopterin phosphate synthase","gtp + h2o -> cPMP + ppi","(MMP0571 and MMP1066)","(moaA and moaC)","Folate biosynthesis",5,"4.1.99.18","Metabolism of cofactors and vitamins","1,2"]
["R396","molybdopterin synthase","cPMP + 2 h2s -> mbpt + 2 h2o","(MMP1235 and MMP1357)","(moaE and moaD)","Folate biosynthesis",5,"2.-.-.-","Metabolism of cofactors and vitamins","1,2"]
["R397","molybdopterin molybdotransferase","ambpt + mobd <=> mocof + amp + h2o","(MMP0201 or MMP0513 or MMP0545 or MMP1619)","MoeA","Folate biosynthesis",5,"2.10.1.1","Metabolism of cofactors and vitamins",3]
["R398","molybdopterin adenylyltransferase","atp + mbpt <=> ppi + ambpt","",null,"Folate biosynthesis",3,"2.7.7.75","Metabolism of cofactors and vitamins",3]
["R399","NAD+ kinase","atp + nad <=> adp + nadp","MMP1489","pnk","Nicotinate and nicotinamide metabolism",5,"2.7.1.23","Metabolism of cofactors and vitamins","1,2"]
["R400","nicotinamide-nucleotide adenylyltransferase","atp + nmn + h <=> ppi + nad","MMP1578",null,"Nicotinate and nicotinamide metabolism",5,"2.7.7.1","Metabolism of cofactors and vitamins","1,2"]
["R401","nicotinamide-nucleotide adenylyltransferase","atp + nicrnt <=> ppi + dnad","MMP1578","","Nicotinate and nicotinamide metabolism",5,"2.7.7.1","Metabolism of cofactors and vitamins","1,2"]
["R402","5'-nucleotidase","nmn + h2o + h -> rnam + pi","MMP1051","surE","Nicotinate and nicotinamide metabolism",5,"3.1.3.5 3.1.3.2","Metabolism of cofactors and vitamins","1,2"]
["R403","5'-nucleotidase","nicrnt + h2o -> nicrns + pi","MMP1051","surE","Nicotinate and nicotinamide metabolism",5,"3.1.3.5 3.1.3.2","Metabolism of cofactors and vitamins","1,2"]
["R404","nicotinate-nucleotide diphosphorylase (carboxylating)","quln + prpp + h -> nicrnt + ppi + co2","MMP0877","nadC","Nicotinate and nicotinamide metabolism",5,"2.4.2.19","Metabolism of cofactors and vitamins","1,2"]
["R405","quinolinate synthase","iasp + dhap -> quln + 2 h2o + pi","MMP1242","nadA","Nicotinate and nicotinamide metabolism",5,"2.5.1.72","Metabolism of cofactors and vitamins","1,2"]
["R406","aspartate dehydrogenase","asp + nadp -> iasp + nadph + h","MMP0737","","Nicotinate and nicotinamide metabolism",5,"1.4.1.21","Metabolism of cofactors and vitamins","1,2"]
["R407","aspartate dehydrogenase","asp + nad -> iasp + nadh + h","MMP0737","","Nicotinate and nicotinamide metabolism",5,"1.4.1.21","Metabolism of cofactors and vitamins","1,2"]
["R408","dihydrofolate reductase","dhf + nadph + h <=> thf + nadp","","","One carbon pool by folate",1,"1.5.1.3","Metabolism of cofactors and vitamins",12]
["R409","phosphoribosylglycinamide formyltransferase","formate + thf + atp -> fthf + adp + pi","",null,"One carbon pool by folate",1,"6.3.4.3","Metabolism of cofactors and vitamins",13]
["R410","hydroxymethylpyrimidine kinase","atp + 4ahmmp -> adp + 4ampm","MMP1639","","Thiamine metabolism",5,"2.7.1.49","Metabolism of cofactors and vitamins","1,2"]
["R411","phosphomethylpyrimidine kinase","4ampm + atp -> 2mahmp + adp","MMP1639","","Thiamine metabolism",5,"2.7.4.7","Metabolism of cofactors and vitamins","1,2"]
["R412","hydroxyethylthiazole kinase","atp + hemt -> adp + 4mpetz","MMP1138","thiM","Thiamine metabolism",5,"2.7.1.50","Metabolism of cofactors and vitamins","1,2"]
["R413","thiamine-phosphate diphosphorylase","2mahmp + 4mpetz -> ppi + thmmp","MMP1139","thiE","Thiamine metabolism",5,"2.5.1.3","Metabolism of cofactors and vitamins","1,2"]
["R414","thiamine monophosphate kinase","atp + thmmp -> adp + thpp","MMP1124","","Thiamine metabolism",5,"2.7.4.16","Metabolism of cofactors and vitamins","1,2"]
["R415","Thiamine biosynthesis","air + sam -> 4ahmmp + dasn + met + formate + co","MMP0187","thiC","Thiamine metabolism",5,"4.1.99.17","Metabolism of cofactors and vitamins","1,2"]
["R416","unclear_thiamine metabolism","g3p + pyr -> hemt","",null,"Thiamine metabolism",3,null,"Metabolism of cofactors and vitamins","1,2"]
["R417","molybdenum cofactor guanylyltransferase","mocof + gtp -> ppi + mgdnt + h","MMP0573","mobA","guanylyl molybdenum cofactor biosynthesis",5,"2.7.7.77","Metabolism of cofactors and vitamins",3]
["R418","2-dehydropantoate aldolase","2oival + fald -> 2dhp","",null,"Pantothenate and CoA biosynthesis",3,"4.1.2.12","Metabolism of cofactors and vitamins","1,2"]
["R419","O-phospho-L-serine tRNA ligase","3pser + trnacys + atp -> pstrna + ppi + amp","MMP0688","","Amino acyl tRNA biosynthesis",5,"6.1.1.27","tRNA charging","1,2"]
["R420","O-phospho-L-seryl-tRNA:Cys-tRNA synthase","pstrna + h2s -> cystrna + pi","MMP1240","","Amino acyl tRNA biosynthesis",5,"2.5.1.73","tRNA charging","1,2"]
["R421","cysteine tRNA ligase","atp + cys + trnacys <=> amp + ppi + cystrna","MMP1060","cysS","Amino acyl tRNA biosynthesis",5,"6.1.1.16","tRNA charging","1,2"]
["R422","methionine tRNA ligase","atp + met + trnamet -> amp + ppi + trnametyl","MMP0326","metG","Amino acyl tRNA biosynthesis",5,"6.1.1.10","tRNA charging","1,2"]
["R423","valine---tRNA ligase","atp + val + trnaval -> amp + ppi + valtrna","MMP0584","valS","Amino acyl tRNA biosynthesis",5,"6.1.1.9","tRNA charging","1,2"]
["R424","leucine---tRNA ligase","atp + leu + trnaleu -> amp + ppi + trnaleucyl","MMP0697","leuS","Amino acyl tRNA biosynthesis",5,"6.1.1.4","tRNA charging","1,2"]
["R425","isoleucine---tRNA ligase","atp + ile + trnaile -> amp + ppi + iletrna","MMP1474","ileS","Amino acyl tRNA biosynthesis",5,"6.1.1.5","tRNA charging","1,2"]
["R426","glutaminyl-tRNA synthase (glutamine-hydrolysing)","trnaglnyl + gln + atp + h2o -> trnaglmn + glu + adp + pi","(MMP0575 and MMP0946 and MMP1265 and MMP1266 and MMP1510)","(gatC and gatA and gatB)","Amino acyl tRNA biosynthesis",5,"6.3.5.7","tRNA charging","1,2"]
["R427","lysine---tRNA ligase","atp + lys + trnalys -> amp + ppi + trnalysyl","MMP1318","lysS","Amino acyl tRNA biosynthesis",5,"6.1.1.6","tRNA charging","1,2"]
["R428","arginine---tRNA ligase","atp + arg + trnaarg -> amp + ppi + argtrna","MMP1026","argS","Amino acyl tRNA biosynthesis",5,"6.1.1.19","tRNA charging","1,2"]
["R429","proline---tRNA ligase","atp + trnapro + pro -> amp + ppi + protrna","MMP0696","proS","Amino acyl tRNA biosynthesis",5,"6.1.1.15","tRNA charging","1,2"]
["R430","histidine---tRNA ligase","atp + his + trnahis -> amp + ppi + histrna","MMP1614","hisS","Amino acyl tRNA biosynthesis",5,"6.1.1.21","tRNA charging","1,2"]
["R431","phenylalanine---tRNA ligase","atp + phe + trnaphe -> amp + ppi + phetrna","(MMP1255 and MMP1496)","(pheT and pheS)","Amino acyl tRNA biosynthesis",5,"6.1.1.20","tRNA charging","1,2"]
["R432","tyrosine---tRNA ligase","atp + tyr + trnatyr -> amp + ppi + tyrtrna","MMP0263","tyrS","Amino acyl tRNA biosynthesis",5,"6.1.1.1","tRNA charging","1,2"]
["R433","tryptophan---tRNA ligase","atp + trp + trnatrp -> amp + ppi + trptrna","MMP1592","trpS","Amino acyl tRNA biosynthesis",5,"6.1.1.2","tRNA charging","1,2"]
["R434","alanine---tRNA ligase","atp + ala + trnaala -> amp + ppi + trnaalanyl","MMP0397","alaS","Amino acyl tRNA biosynthesis",5,"6.1.1.7","tRNA charging","1,2"]
["R435","aspartate---tRNA ligase","trnaasp + asp + atp -> asptrna + ppi + amp","MMP1616","aspC","Amino acyl tRNA biosynthesis",5,"6.1.1.12","tRNA charging","1,2"]
["R436","asparaginyl-tRNA synthase (glutamine-hydrolysing)","asntrna + gln + atp + h2o -> trnaasnyl + glu + adp + pi","(MMP0575 and MMP0946 and MMP1510)","(gatC and gatA and gatB)","Amino acyl tRNA biosynthesis",5,"6.3.5.6","tRNA charging","1,2"]
["R437","glycine---tRNA ligase","atp + gly + trnagly -> amp + ppi + glytrna","MMP0212","","Amino acyl tRNA biosynthesis",5,"6.1.1.14","tRNA charging","1,2"]
["R438","threonine---tRNA ligase","atp + thr + trnathr -> amp + ppi + thrtrna","MMP0414","thrS","Amino acyl tRNA biosynthesis",5,"6.1.1.3","tRNA charging","1,2"]
["R439","serine---tRNA ligase","atp + ser + trnaser -> amp + ppi + sertrna","MMP0879","serS","Amino acyl tRNA biosynthesis",5,"6.1.1.11","tRNA charging","1,2"]
["R440","serine---tRNA ligase","atp + ser + trnasec -> amp + ppi + trnaseryl","MMP0879","serS","Amino acyl tRNA biosynthesis",5,"6.1.1.11","tRNA charging","1,2"]
["R441","acetolactate decarboxylase","alac-S -> actn-R + co2","MMP0613",null,"Amino acyl tRNA biosynthesis",5,"4.1.1.5","tRNA charging","1,2"]
["R442","coenzyme F420 hydrogenase","cof420 + h2 <=> cof420h2","(MMP0083 and MMP0817 and MMP0818 and MMP0819 and MMP0820 and MMP1382 and MMP1383 and MMP1384 and MMP1385 and MMP1337)","(frcB and frcG and frcD and frcA and fruA and fruD and fruG and fruB)","Amino acyl tRNA biosynthesis",5,"1.12.98.1","tRNA charging","1,2"]
["R443","glutamine---tRNA ligase","atp + gln + trnagln <=> amp + ppi + trnaglnyl","",null,"Amino acyl tRNA biosynthesis",3,"6.1.1.18","tRNA charging",3]
["R444","asparagine---tRNA ligase","trnaasn + atp + asn <=> trnaasnyl + ppi + amp","",null,"Amino acyl tRNA biosynthesis",3,"6.1.1.22","tRNA charging",3]
["R445","thioredoxin-disulfide reductase","2 nadph + 2 h + metsela -> 2 nadp + 2 h2o + mthsel","MMP0959","trxB","Selenocompound metabolism",5,"1.8.1.9","others","1,2"]
["R446","thioredoxin-disulfide reductase","selt + 3 nadph + 5 h -> seld + 3 nadp + 3 h2o","MMP0959","trxB","Selenocompound metabolism",5,"1.8.1.9","others","1,2"]
["R447","5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase","shcys + 5mthg_e -> semth + mthg_e","MMP0401","metE","Selenocompound metabolism",5,"2.1.1.14","others","1,2"]
["R448","selenide, water dikinase","atp + seld + h2o <=> amp + pi + selp","MMP0904","selD","Selenocompound metabolism",5,"2.7.9.3","others","1,2"]
["R449","O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase","trnapseryl + selp + h2o <=> trnaselcys + pi","MMP0595","","Selenocompound metabolism",5,"2.9.1.2","others","1,2"]
["R450","spermidine synthase","sama + cadv -> 5mta + apcad + h","MMP1584","","Glutathione metabolism",5,"2.5.1.16","others","1,2"]
["R451","L-seryl-tRNA(Sec) kinase","trnaseryl + atp -> trnapseryl + adp","MMP1490","","Selenocompound metabolism",5,"2.7.1.164","others","1,2"]
["R452","L-seryl-tRNASec selenium transferase","trnaseryl + selp -> trnaselcys + pi","MMP0002","","Selenocompound metabolism",5,"2.9.1.1","others","1,2"]
["R453","methionine tRNA ligase","atp + semth + trnamet -> amp + ppi + trnaselmet","MMP0326","metG","Selenocompound metabolism",5,"6.1.1.10","others","1,2"]
["R454","hydroxymethylglutaryl-CoA reductase (NADPH)","hmgcoa + 2 nadph + 2 h -> mev-R + coa + 2 nadp","MMP0087","hmgA","Terpenoid backbone biosynthesis",5,"1.1.1.34","others","1,2"]
["R455","mevalonate kinase","atp + mev-R -> adp + 5pmev","MMP1335",null,"Terpenoid backbone biosynthesis",5,"2.7.1.36","others","1,2"]
["R456","isopentenyl-diphosphate Delta-isomerase","ipdp <=> dmpp","MMP0043",null,"Terpenoid backbone biosynthesis",5,"5.3.3.2","others","1,2"]
["R457","dimethylallyltranstransferase","dmpp + ipdp -> ppi + grdp","MMP0045","idsA","Terpenoid backbone biosynthesis",5,"2.5.1.1","others","1,2"]
["R458","geranylgeranyl diphosphate synthase","ttfdp + ipdp -> ppi + ggdp","MMP0045","idsA","Terpenoid backbone biosynthesis",5,"2.5.1.29","others","1,2"]
["R459","(2E,6E)-farnesyl diphosphate synthase","grdp + ipdp -> ppi + ttfdp","MMP0045","idsA","Terpenoid backbone biosynthesis",5,"2.5.1.10","others","1,2"]
["R460","ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]","ttfdp + 8 ipdp -> tcudp + 8 ppi","MMP1345",null,"Terpenoid backbone biosynthesis",5,"2.5.1.31","others","1,2"]
["R461","phosphomevalonate kinase","atp + 5pmev -> adp + 5dpmev","",null,"Terpenoid backbone biosynthesis",3,"2.7.4.2","others",3]
["R462","diphosphomevalonate decarboxylase","5dpmev + atp -> adp + pi + ipdp + co2","",null,"Terpenoid backbone biosynthesis",3,"4.1.1.33","others",3]
["R463","alcohol dehydrogenase","tcpl + nad -> claald + nadh + h","MMP0802",null,"Chloroalkane and chloroalkene degradation",5,"1.1.1.1","others","1,2"]
["R464","alcohol dehydrogenase","ccpl + nad -> ccald + nadh + h","MMP0802",null,"Chloroalkane and chloroalkene degradation",5,"1.1.1.1","others","1,2"]
["R465","nitrogenase","actyn + fdxrd + 2 h + atp + h2o -> c2h4 + fdox + adp + pi","(MMP0147 and MMP0853 and MMP0856 and MMP0857 and MMP0858 and MMP0859 and MMP0860)","(nifH and nifD and nifK and nifE and nifN and nifX)","Chloroalkane and chloroalkene degradation",5,"1.18.6.1","others","1,2"]
["R466","pyruvate synthase","24dnt -> dhamt","(MMP1502 and MMP1503 and MMP1504 and MMP1505 and MMP1506 and MMP1507)","(porB and porA and porD and porC and porE and porF)","Nitrotoluene degradation",5,"1.2.7.1 1.12.99.2","others","1,2"]
["R467","Iron-containing alcohol dehydrogenase","hmnapth + nad -> napthah + nadh + h","MMP0802",null,"Naphthalene degradation",5,"1.1.1.1","others","1,2"]
["R468","Iron-containing alcohol dehydrogenase","napthm + nad -> naptal + nadh + h","MMP0802",null,"Naphthalene degradation",5,"1.1.1.1","others","1,2"]
["R469","methylglyoxal synthase","dhap -> pi + mglyx","",null,"Pyruvate metabolism",4,"4.2.3.3","Carbohydrate metabolism",4]
["R470","6-deoxy-5-ketofructose 1-phosphate synthase","mglyx + fpp -> dkfp + g3p","MMP0293",null,"Pyruvate metabolism",5,"2.2.1.11","Carbohydrate metabolism","1,2,4"]
["R471","pyruvate, water dikinase","atp + pyr + h2o -> amp + pep + pi","MMP1094","ppsA","Pyruvate metabolism",5,"2.7.9.2","Carbohydrate metabolism","1,2"]
["R472","acetyl-CoA C-acetyltransferase","2 accoa <=> coa + aacoa","MMP1212","","Pyruvate metabolism",5,"2.3.1.9","Carbohydrate metabolism","1,2"]
["R473","acetate---CoA ligase","actn + coa <=> amp + accoa","(MMP0148 or MMP1274)","acsA","Pyruvate metabolism",5,"6.2.1.1","Carbohydrate metabolism","1,2"]
["R474","pyruvate formate-lyase","pyr + coa -> accoa + formate","MMP1358",null,"Pyruvate metabolism",5,"2.3.1.54 1.97.1.4","Carbohydrate metabolism","1,2"]
["R475","glutamine---fructose-6-phosphate transaminase (isomerizing)","gln + f6p -> glu + gam6p","MMP1680","glmS","Amino sugar and nucleotide metabolism",5,"2.6.1.16","Carbohydrate metabolism","1,2"]
["R476","phosphoglucosamine mutase","gam6p -> gam1p","MMP1077","","Amino sugar and nucleotide metabolism",5,"5.4.2.10","Carbohydrate metabolism","1,2"]
["R477","UDP-N-acetylglucosamine diphosphorylase","utp + nagn1p -> ppi + uacgam","MMP1076","","Amino sugar and nucleotide metabolism",5,"2.7.7.23","Carbohydrate metabolism","1,2"]
["R478","glucosamine-1-phosphate N-acetyltransferase","accoa + gam1p -> coa + nagn1p","MMP1076","","Amino sugar and nucleotide metabolism",5,"2.3.1.157","Carbohydrate metabolism","1,2"]
["R479","UDP-N-acetylglucosamine 2-epimerase","uacgam + h2o -> acmana + udp","(MMP0357 or MMP0705)","wbpI","Amino sugar and nucleotide metabolism",5,"5.1.3.14","Carbohydrate metabolism","1,2"]
["R480","UDP-N-acetyl-D-mannosamine dehydrogenase","uacmam + 2 nad + h2o -> uacmau + 2 nadh + 2 h","MMP0706","","Amino sugar and nucleotide metabolism",5,"1.1.1.336","Carbohydrate metabolism","1,2"]
["R481","acetolactate decarboxylase","aclact <=> actn-R + co2","MMP0613","","Butanoate metabolism",5,"4.1.1.5","Amino acid metabolism","1,2"]
["R482","acetolactate synthase","2hethpp + pyr -> aclact + thpp","(MMP0142 or MMP0650 or MMP0651)","(ilvB or ilvH)","Butanoate metabolism",5,"2.2.1.6","Amino acid metabolism","1,2"]
["R483","acetolactate synthase","2 pyr -> alac-S + co2","(MMP0142 or MMP0650 or MMP0651)","(ilvB or ilvH)","C5 Branched dibasic acid metabolism",5,"2.2.1.6","Carbohydrate metabolism","1,2"]
["R484","succinate---CoA ligase (ADP-forming)","atp + itcn + coa <=> adp + pi + itcncoa","(MMP0955 and MMP1105)","(sucC and sucD)","C5 Branched dibasic acid metabolism",5,"6.2.1.5","Carbohydrate metabolism","1,2"]
["R485","(R)-2-methylmalate dehydratase","r2mm -> 2mm + h2o","(MMP0136 and MMP1149)","(leuC and leuD)","C5 Branched dibasic acid metabolism",5,"4.2.1.35","Carbohydrate metabolism","1,2"]
["R486","phosphomannomutase","man6p <=> man1p","MMP1372","manB","Pentose and glucuronate interconversions",5,"5.4.2.8","Carbohydrate metabolism","1,2"]
["R487","L-fuculose-phosphate aldolase","fc1p -> dhap + lacald","MMP1187","fucA","Pentose and glucuronate interconversions",5,"4.1.2.17","Carbohydrate metabolism","1,2"]
["R488","UDP-glucose 4-epimerase","udp-glu <=> udpDgal","MMP1090","","Galactose metabolism",5,"5.1.3.2","Carbohydrate metabolism","1,2"]
["R489","formate dehydrogenase","formate + nad -> h + co2 + nadh","(MMP0138 and MMP0139 and MMP1297 and MMP1298)","(fdhA and fdhB)","Glyoxylate and dicarboxylate metabolism",5,"1.2.1.2","Carbohydrate metabolism","1,2"]
["R490","glycerate dehydrogenase","dgly + nad <=> hpyr + nadh + h","MMP0870","","Glyoxylate and dicarboxylate metabolism",5,"1.1.1.29","Carbohydrate metabolism","1,2"]
["R491","glycerate dehydrogenase","glyclt + nad <=> glx + nadh + h","MMP0870","","Glyoxylate and dicarboxylate metabolism",5,"1.1.1.29","Carbohydrate metabolism","1,2"]
["R492","UTP---glucose-1-phosphate uridylyltransferase","utp + g1p <=> ppi + udp-glu","MMP1091",null,"Pentose and glucuronate interconversions",5,"2.7.7.9","Carbohydrate metabolism","1,2"]
["R493","acetate---CoA ligase","padn + coa <=> amp + ppcoa","(MMP0148 or MMP1274)","acsA","Propanoate metabolism",5,"6.2.1.1","Carbohydrate metabolism","1,2"]
["R494","acetate---CoA ligase","ppi + padn -> atp + prnoate","(MMP0148 or MMP1274)","acsA","Propanoate metabolism",5,"6.2.1.1","Carbohydrate metabolism","1,2"]
["R495","acetate---CoA ligase (ADP-forming)","atp + prnoate + coa <=> adp + pi + ppcoa","MMP0253","acd","Propanoate metabolism",5,"6.2.1.13","Carbohydrate metabolism","1,2"]
["R496","UDP-N-acetylglucosamine 2-epimerase","uacgam -> uacmam","(MMP0357 or MMP0705)","wbpI","Amino sugar and nucleotide metabolism",5,"5.1.3.14","Carbohydrate metabolism",8]
["R497","mannose-6-phosphate isomerase","f6p -> man1p","","","GDP-mannose biosynthesis",3,"5.3.1.8","Carbohydrate metabolism",3]
["R498","mannose-1-phosphate guanylyltransferase","man1p + gtp -> gdpman + ppi","MMP1076",null,"GDP-mannose biosynthesis",5,"2.7.7.13","Carbohydrate metabolism",3]
["R499","hydroxymethylglutaryl-CoA synthase","accoa + h2o + aacoa -> coa + hmgcoa","MMP1211",null,"Butanoate metabolism",5,"2.3.3.10","Carbohydrate metabolism","1,2"]
["R500","Oxalate decarboxylase","oxa -> co2 + formate","",null,"Glyoxylate and dicarboxylate metabolism",2,"4.1.1.2","Carbohydrate metabolism",17]
["R501","acetaldehyde dehydrogenase (acetylating)","acald + nad + coa -> nadh + h + accoa","",null,"ethanol degradation I, pyruvate fermentation to ethanol III",2,"1.2.1.10","Carbohydrate metabolism",3]
["R502","citrate (Si)-synthase","accoa + h2o + oaa -> coa + cit","",null,"respiration (anaerobic)",3,"2.3.3.1","Amino acid metabolism","3,16"]
["R503","aconitate hydratase","cacn + h2o -> icit","",null,"respiration (anaerobic)",3,"4.2.1.3","Amino acid metabolism",3]
["R504","isocitrate dehydrogenase (NADP+","icit + 2 nadp -> co2 + 2 nadph + 2oxglu","MMP0539","leuB","respiration (anaerobic)",2,"1.1.1.42","Amino acid metabolism","3, 16"]
["R505","phosphorylase","2 amy + pi <=> amy + g1p","MMP1220","glgP","Glycogen synthesis",5,"2.4.1.1","Carbohydrate metabolism","1,2"]
["R506","phosphorylase","amy + g1p -> 2 glycogen + pi","MMP1220","glgP","Glycogen synthesis",5,"2.4.1.1","Carbohydrate metabolism","1,2"]
["R507","glycogen synthase (UDPGlc)","udp-glu -> glycogen + udp","MMP1294","glgA","Glycogen synthesis",3,"2.4.1.11","Carbohydrate metabolism",5]
["R508","glucan 1,4-alpha-glucosidase","glycogen + h2o -> glc","MMP1292",null,"Glycogen degradation",3,"3.2.1.3","Carbohydrate metabolism",17]
["R509","acetyl-CoA C-acetyltransferase","accoa + bcoa <=> coa + ohcoa","MMP1212",null,"Fatty acid metabolism",5,"2.3.1.9","Lipid metabolism","1,2"]
["R510","Glycerol dehydrogenase","dhap + nadh + h -> glyc1p + nad","MMP0225","gldA","Glycerophospholipid metabolism",5,"1.1.1.261 1.1.1.6","Lipid metabolism","1,2"]
["R511","Glycerol dehydrogenase","dhap + nadph + h -> nadp + glyc1p","MMP0225","gldA","Glycerophospholipid metabolism",5,"1.1.1.261 1.1.1.6","Lipid metabolism","1,2"]
["R512","phosphoglycerol geranylgeranyltransferase","glyc1p + ggdp -> ppi + ggrglyc1p","MMP0007",null,"Glycerophospholipid metabolism",5,"2.5.1.41","Lipid metabolism","1,2"]
["R513","tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]","ggdp + 7 ipdp -> 7 ppi + tthcudp","MMP1345",null,"Glycerophospholipid metabolism",2,"2.5.1.89","Lipid metabolism","1,2"]
["R514","geranylgeranylglycerol-phosphate geranylgeranyltransferase","ggrglyc1p + ggdp -> ppi + 23gglyc1p","MMP1677",null,"Glycerophospholipid metabolism",5,"2.5.1.42","Lipid metabolism","1,2"]
["R515","CDP-archaeol synthase","ctp + 23gglyc1p -> ppi + CDP-archaeol","",null,"Glycerophospholipid metabolism",4,"2.7.7.67","Lipid metabolism",19]
["R516","Carbon dioxide transport","co2_e <=> co2","",null,"CO2 transporter via diffusion",5,null,"transport reaction",17]
["R517","Cobalt ABC transporter","co+2_e + atp + h2o <=> co+2 + adp + pi","(MMP0886 or MMP0888 or MMP0889 or MMP1481 or MMP1482 or MMP1483 or MMP1484)","(CbiN or CbiM or CbiQ or CbiO)","ATP driven transporters",5,null,"transport reaction","1,2"]
["R518","cysteine transport","cys_e + h_e <=> cys + h","",null,"L-cysteine reversible transport via proton symport",5,null,"transport reaction",17]
["R519","Hydrogen sulfide transport","h2s_e <=> h2s","",null,"h2s transport (diffusion)",5,null,"transport reaction",17]
["R520","Hydrogen transport","h2_e <=> h2","",null,"hydrogen transport",5,null,"transport reaction",17]
["R521","Indole3acetate transport","ind3ac + h <=> ind3ac_e + h_e","MMP1092",null,"auxin efflux carrier/Secondary Transporters ",5,null,"transport reaction",3]
["R522","Fe3+-transporting ATPase","Fe3_e + atp + h2o <=> fe3 + adp + pi","MMP0110",null,"ATP driven transporters",5,"3.6.3.30","transport reaction","1,2"]
["R523","iron-chelate-transporting ATPase","Fe3_e + atp + h2o <=> fe3 + adp + pi","(MMP0198 or MMP1183)",null,"ABC-type (ATP-binding cassette-type) ATPase",5,null,"transport reaction","1,2"]
["R524","ABC-type iron(III) transport system periplasmic binding protein","Fe3_e <=> fe3 ","(MMP0196 or MMP0108)",null,"ABC transporters",5,null,"transport reaction","1,2"]
["R525","ABC-type iron(III) transport system permease","Fe3_e <=> fe3 ","MMP0197","afuB_1","Permease",5,null,"transport reaction","1,2"]
["R526","Magnesium transport via ABC transporter","mg2_e + atp + h2o <=> mg2 + adp + pi","(MMP1108 or MMP0711)","corA\n","ATP driven transporters",5,null,"transport reaction","1,2"]
["R527","Ammonium transport","nh4_e <=> nh4 ","(MMP0065 or MMP0068)","amtB","Ammonium transporters",5,"3.6.3.32","transport reaction",3]
["R528","Methane transport","ch4 <=> ch4_e","",null,"Methane transport",5,null,"transport reaction",17]
["R529","Molybdnum transport","mo_e + atp + h2o <=> mo + adp + pi","(MMP0205 or MMP0507 or MMP0514 or MMP0975 or MMP1651 or MMP0206 or MMP0506 or MMP0515 or MMP1650 or MMP0207 or MMP0504 or MMP1649)","(ModA or ModB or ModC)","ATP driven transporters",5,"3.6.3.29","transport reaction","1,2"]
["R530","Molybdate transport","atp + mobd_e + h2o <=> adp + pi + mobd","(MMP0205 or MMP0507 or MMP0514 or MMP0975 or MMP1651 or MMP0206 or MMP0506 or MMP0515 or MMP1650 or MMP0207 or MMP0504 or MMP1649)","(ModA or ModB or ModC)","ATP driven transporters",5,null,"transport reaction","1,2"]
["R531","Nickel transport","ni2_e <=> ni2","(MMP0886 or MMP0888 or MMP0889 or MMP1481 or MMP1483 or MMP1484 or MMP0271)","(CbiM or CbiQ or CbiO)","ABC transporter",5,null,"transport reaction","1,2"]
["R532","Nitrogen transport","n2_e <=> n2","",null,"Nitrogen transport, diffusion",5,null,"transport reaction",3]
["R533","sodium/proline symporter","na_e + pro_e <=> na + pro","(MMP0220 or MMP0221)","putP","sodium:proline symporter/Secondary Transporters ",5,null,"transport reaction",3]
["R534","Selenite transport","selnt_e <=> selt","",null,"Selenite transport",5,null,"transport reaction"]
["R535","Sodium transport","na_e + h_e <=> na + h","(MMP0100 or MMP0484 or MMP0587 or MMP0864 or MMP0707)","(napA or napA-2)","sodium/hydrogen exchanger",5,null,"transport reaction",3]
["R536","Sulfite transport","h_e + so3_e <=> h + so3","",null,"sulfite transport exchange via proton symport",5,null,"transport reaction"]
["R537","Sulfate transport via ABC transporter","h2o + atp + so4_e <=> adp + so4 + pi","(MMP0529 or MMP0663 or MMP1518)",null,"ATP driven transporters",5,null,"transport reaction",3]
["R538","Water transport","h2o_e <=> h2o","",null,"H2O transport via diffusion",5,null,"transport reaction",17]
["R539","Orthophosphate transport","pi_e <=> pi","(MMP0345 or MMP1095 or MMP1096 or MMP1097 or MMP1098 or MMP1199 or MMP1099)","PhoU","ABC transporter",5,null,"transport reaction","1,2"]
["R540","Urea transport","urea <=> urea_e","",null,"Urea transport via facilitate diffusion",5,null,"transport reaction",17]
["R541","S-Methyl-5-thio-D-ribose 1-phosphate_transport","mtr1p <=> mtr1p_e","MMP0796",null,"sugar efflux transporter/unknown mechanism",5,null,"transport reaction",3]
["R542","Oxygen transport","oxygen_e <=> oxygen","",null,"Oxygen transport",5,null,"transport reaction"]
["R543","Acetate transport","acetate_e + h_e <=> acetate + h","",null,"acetate reversible transport via proton symport",1,null,"transport reaction",17]
["R544","Alanine transport","ala_e + na_e <=> ala + na","MMP1511",null,"Alanine-Sodium symporter",5,null,"transport reaction",17]
["R545","Iron transport via channel","fe2_e <=> fe2","MMP0630","feoB","ferrous iron transport",5,null,"transport reaction","1,2"]
["R546","Sulfate transporter via permease","so4_e <=> so4","MMP0529 or MMP0663",null,"(Sulfate transporter via permease)",5,null,"transport reaction","1,2"]
["R547","Bicarbonate ABC transporter ATPase","hco3_e + atp + h2o <=> hco3 + adp + pi","MMP1198",null,"Bicarbonate ABC transporter ATPase",5,null,"transport reaction","1,2"]
["R548","Cytosine permease","csn_e + h_e <=> csn + h","MMP0789","codB","Cytosine permease",5,null,"transport reaction","1,2"]
["R549","proline transport","pro_e <=> pro","(MMP0866 or MMP0867 or MMP0868)","(proX or proW or proV)","proline transport",5,null,"transport reaction","1,2"]
["R550","Tungstate ABC transport","w_e <=> w","(MMP1652 or MMP1519 or MMP1518)","(WtpC or WtpB or WtpA)","Tungstate ABC transport",5,null,"transport reaction","1,2"]
["R551","xanthine/uracil permease","xan_e + ura_e <=> xan + ura","(MMP0689 or MMP0681)",null,"xanthine/uracil permease",5,null,"transport reaction","1,2"]
["R552","5'-Deoxyadenosine transport","dasn <=> dasn_e","",null,"5'-Deoxyadenosine transport",2,null,"transport reaction"]
["R553","(2S)-2-Phospholactate transport","2plac_e <=> 2plac","",null,"(2S)-2-Phospholactate transport",2,null,"transport reaction"]
["R554","Biotin proton symport","btn_e + h_e <=> btn + h","",null,null,5,null,"transport reaction","1,2"]
["R555","1-Hydroxyhexane-1,2,6-tricarboxylate transport","1hydtc_e <=> 1hydtc","",null,null,2,null,"transport reaction"]
["R556","S-Adenosyl-4-methylthio-2-oxobutanoate transport","amob <=> amob_e","",null,null,2,null,"transport reaction"]
["R557","Ribazole transport","rbz <=> rbz_e","",null,null,2,null,"transport reaction"]
["R558","Glycoaldehyde transport","Glycald <=> Glycald_e","",null,null,2,null,"transport reaction"]
["R559","L-lysine/homoserine-homoserine lactone exporter family protein","lys <=> lys_e","MMP0849",null,null,5,null,"transport reaction","1,2"]
["R560","ammonia transport","nh3_e <=> nh3","(MMP0065 or MMP0068)","amtB",null,5,null,"transport reaction","1,2"]
["R561","formate/nitrite transporter","formate_e <=> formate","MMP1301","fdhC","Channel type transporters",5,null,"transport reaction",3]
["R562","Alanine transport via permease","ala_e <=> ala","",null,null,5,null,"transport reaction"]
["R563","Cd2+-exporting ATPase","atp + h2o + cd2 <=> adp + pi + cd2_e","MMP0216",null,"P-type ATPase",5,null,"transport reaction","1,2"]
["R564","Pimelate transport","pim <=> pim_e","",null,"Pimelate transport",5,null,"transport reaction"]
["R565","Biomass Reaction","0.22 rna + 0.0344 dna + 0.6097 protein + 0.0034 glycogen + 30 atp + 0.0243 Solublepools + 0.1009 phosphoplipid -> biomass + 30 adp + 30 pi","",null,"Biomass Formation",4,"","biomass",""]
["R566","DNA synthesis","0.504 dgtp + 1.075 datp + 0.571 dctp + 1.093 dttp -> dna + 3.242 ppi","",null,"DNA synthesis",4,"2.7.7.7","biomass"]
["R567","Phospholipid synthesis","20.8 accoa + 1.95 g3p + 0.65 ser + 44.2 atp + 38.35 nadh + 0.8 CDP-archaeol -> 20.8 coa + 44.2 adp + 0.65 co2 + phosphoplipid + 38.35 nad","",null,"Phospholipid synthesis",4,"","biomass",""]
["R568","Protein synthesis","0.77 gly + 0.96 ala + 0.67 val + 0.85 leu + 0.44 ile + 0.46 ser + 0.48 thr + 0.3 phe + 0.01 trp + 0.26 tyr + 0.15 cys + 0.22 met + 0.54 lys + 0.46 arg + 0.16 his + 0.46 asp + 0.52 glu + 0.46 asn + 0.52 gln + 0.34 pro -> protein","",null,"Protein synthesis",4,"","biomass",""]
["R569","RNA synthesis","0.789 utp + 0.708 ctp + 0.82 atp + 0.783 gtp -> rna + 3.107 ppi","",null,"RNA synthesis",4,"2.7.7.6","biomass"]
["R570","Soluble pools","0.0012 cof430 + 0.0126 ptrc + 0.0055 spermn + 0.0014 cof420 + 0.0022 cof420-0 + 0.0017 cof420-1 + 0.0012 cof420-3 + 0.0032 amp + 0.0034 cob + 0.0012 sheme + 0.0007 VitB12 + 0.0014 coa + 0.0017 nad + 0.0017 nadh + 0.0015 nadp + 0.0015 nadph + 0.0045 btn + 0.0029 ribflv + 0.0072 COM + 0.001 thmpt -> Solublepools","",null,"Soluble pools",4,null,"biomass"]

{"sheet":"Metabolites","index":1,"n_rows":606,"n_cols":5,"rows_kept":606,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Metabolite name","Metabolite description","Metabolite formula","Metabolite Compartment","KEGG ID"]
["g1p","D-Glucose 1-phosphate","C6H13O9P","Cytosol","C00103"]
["g6p","D-Glucose 6-phosphate","C6H13O9P","Cytosol","C00092"]
["adp","Adenosine 5'-diphosphate","C10H15N5O10P2","Cytosol","C00008"]
["glc","D-Glucose","C6H12O6","Cytosol","C00031"]
["amp","Adenosine 5'-monophosphate","C10H14N5O7P","Cytosol","C00020"]
["g3p","D-Glyceraldehyde 3-phosphate","C3H7O6P","Cytosol","C00118"]
["nadp","Nicotinamide adenine dinucleotide phosphate","C21H29N7O17P3","Cytosol","C00006"]
["h2o","Water","H2O","Cytosol","C00001"]
["3pg","3-Phospho-D-glycerate","C3H7O7P","Cytosol","C00197"]
["nadph","Reduced nicotinamide adenine dinucleotide phosphate","C21H30N7O17P3","Cytosol","C00005"]
["h","Hydron","H","Cytosol","C00080"]
["atp","Adenosine 5'-triphosphate","C10H16N5O13P3","Cytosol","C00002"]
["13dpg","3-Phospho-D-glyceroyl phosphate","C3H8O10P2","Cytosol","C00236"]
["2pg","2-Phospho-D-glycerate","C3H7O7P","Cytosol","C00631"]
["pep","Phosphoenolpyruvate","C3H5O6P","Cytosol","C00074"]
["pyr","Pyruvate","C3H4O3","Cytosol","C00022"]
["fdox","Oxidized ferredoxin","fd","Cytosol","C00139"]
["coa","Coenzyme A","C21H36N7O16P3S","Cytosol","C00010"]
["fdxrd","Reduced ferredoxin","fdH2","Cytosol","C00138"]
["accoa","Acetyl coenzyme A","C23H38N7O17P3S","Cytosol","C00024"]
["co2","Carbon dioxide","CO2","Cytosol","C00011"]
["en6lip","Enzyme N6-(dihydrolipoyl)lysine","C8H16NOS2R","Cytosol","C15973"]
["nad","Nicotinamide adenine dinucleotide","C21H28N7O14P2","Cytosol","C00003"]
["e6lip","en6liplys","C8H14NOS2R","Cytosol","C15972"]
["nadh","NADH; DPNH; Reduced nicotinamide adenine dinucleotide","C21H29N7O14P2","Cytosol","C00004"]
["etoh","Ethanol","C2H6O","Cytosol","C00469"]
["acald","Acetaldehyde","C2H4O","Cytosol","C00084"]
["f6p","D-Fructose 6-phosphate","C6H13O9P","Cytosol","C00085"]
["fpp","D-Fructose 1,6-bisphosphate","C6H14O12P2","Cytosol","C00354"]
["pi","Orthophosphate","H3PO4","Cytosol","C00009"]
["dhap","Glycerone phosphate","C3H7O6P","Cytosol","C00111"]
["mal","S Malate","C4H6O5","Cytosol","C00149"]
["ppcoa","Propanoyl-CoA","C24H40N7O17P3S","Cytosol","C00100"]
["2oxbut","2-Oxobutanoate","C4H6O3","Cytosol","C00109"]
["oaa","Oxaloacetate","C4H4O5","Cytosol","C00036"]
["acetate","Acetate","C2H4O2","Cytosol","C00033"]
["ppi","Diphosphate","P2H4O7","Cytosol","C00013"]
["hco3","Bicarbonate","HCO3","Cytosol","C00288"]
["fum","Fumarate","C4H4O4","Cytosol","C00122"]
["succ","Succinate","C4H6O4","Cytosol","C00042"]
["succoa","Succinyl-CoA","C25H40N7O19P3S","Cytosol","C00091"]
["2oxglu","2-Oxoglutarate","C5H6O5","Cytosol","C00026"]
["ru5p","D-Ribulose 5-phosphate","C5H11O8P","Cytosol","C00199"]
["x5p","D-Xylulose 5-phosphate","C5H11O8P","Cytosol","C00231"]
["rib-D","D-Ribose","C5H10O5","Cytosol","C00121"]
["r5p","D-Ribose 5-phosphate","C5H11O8P","Cytosol","C00117"]
["prpp","5-Phospho-alpha-D-ribose 1-diphosphate","C5H13O14P3","Cytosol","C00119"]
["ahup","D-arabino-Hex-3-ulose 6-phosphate","C6H13O9P","Cytosol","C06019"]
["s7p","Sedoheptulose 7-phosphate","C7H15O10P","Cytosol","C05382"]
["e4p","D-Erythrose 4-phosphate","C4H9O7P","Cytosol","C00279"]
["fald","Formaldehyde","CH2O","Cytosol","C00067"]
["r1p","D-Ribose 1-phosphate","C5H11O8P","Cytosol","C00620"]
["h2","Hydrogen","H2","Cytosol","C00282"]
["fmfr","Formylmethanofuran","C35H44N4O16","Cytosol","C01001"]
["formate","Formate","CH2O2","Cytosol","C00058"]
["mfr","Methanofuran","C34H44N4O15","Cytosol","C00862"]
["thmpt","5,6,7,8-Tetrahydromethanopterin","C30H45N6O16P","Cytosol","C01217"]
["fthmpt","5-Formyl-5,6,7,8-tetrahydromethanopterin","C31H45N6O17P","Cytosol","C01274"]
["methmpt","5,10-Methenyltetrahydromethanopterin","C31H44N6O16P","Cytosol","C04330"]
["mtthmpt","5,10-Methylenetetrahydromethanopterin; N5,N10-Methylenetetrahydromethanopterin","C31H45N6O16P","Cytosol","C04377"]
["cof420h2","Reduced coenzyme F420","C29H38N5O18P","Cytosol","C01080"]
["cof420","Coenzyme F420","C29H36N5O18P","Cytosol","C00876"]
["34hpp","3-(4-Hydroxyphenyl)pyruvate","C9H8O4","Cytosol","C01179"]
["aribau","5-Amino-6-(1-D-ribitylamino)uracil","C9H16N4O6","Cytosol","C04732"]
["sam","S-Adenosyl-L-methionine","C15H22N6O5S","Cytosol","C00019"]
["ddhrb","7,8-Didemethyl-8-hydroxy-5-deazariboflavin","C16H17N3O7","Cytosol","C19154"]
["met","L-Methionine","C5H11NO2S","Cytosol","C00073"]
["dasn","5'-Deoxyadenosine","C10H13N5O3","Cytosol","C05198"]
["oxa","Oxalate","C2H2O4","Cytosol","C00209"]
["nh3","Ammonia","NH3","Cytosol","C00014"]
["ldpg","(2S)-Lactyl-2-diphospho-5'-guanosine","C13H19N5O13P2","Cytosol","C19155"]
["cof420-0","Coenzyme F420-0","C19H22N3O12P","Cytosol","C19153"]
["gmp","Guanosine monophosphate","C10H14N5O8P","Cytosol","C00144"]
["gtp","Guanosine 5'-triphosphate","C10H16N5O14P3","Cytosol","C00044"]
["glu","L-Glutamate","C5H9NO4","Cytosol","C00025"]
["cof420-1","Coenzyme F420-1","C24H29N4O15P","Cytosol","C19152"]
["gdp","Guanosine 5'-diphosphate","C10H15N5O11P2","Cytosol","C00035"]
["2plac","(2S)-2-Phospholactate","C3H7O6P","Cytosol","C19156"]
["cof420-3","Coenzyme F420-3","C34H43N6O21P","Cytosol","C19151"]
["mthmpt","5-Methyl-5,6,7,8-tetrahydromethanopterin","C31H47N6O16P","Cytosol","C04488"]
["co","Carbon monoxide","CO","Cytosol","C00237"]
["COM","2-Mercaptoethanesulfonate","C2H6O3S2","Cytosol","C03576"]
["mteths","2-(Methylthio)ethanesulfonate","C3H8O3S2","Cytosol","C03920"]
["cob","Coenzyme B","C11H22NO7PS","Cytosol","C04628"]
["com-s-s-cob","Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide","C13H26NO10PS3","Cytosol","C04832"]
["ch4","Methane","CH4","Cytosol","C01438"]
["dhmtpz","Dihydromethanophenazine; 2-(Dihydropentaprenyloxy)-dihydrophenazine","C37H52N2O","Cytosol","C11904"]
["mthp","Methanophenazine","C37H50N2O","Cytosol","C11903"]
["so3","Sulfite","H2SO3","Cytosol","C00094"]
["pslac","(2R)-O-Phospho-3-sulfolactate","C3H7O9PS","Cytosol","C11536"]
["slac","(2R)-3-Sulfolactate","C3H6O6S","Cytosol","C11537"]
["3spyr","3-Sulfopyruvate","C3H4O6S","Cytosol","C05528"]
["sald","Sulfoacetaldehyde","C2H4O4S","Cytosol","C00593"]
["thf","Tetrahydrofolate","C19H23N7O6","Cytosol","C00101"]
["mlthf","5,10-Methylenetetrahydrofolate","C20H23N7O6","Cytosol","C00143"]
["ser","L-Serine","C3H7NO3","Cytosol","C00065"]
["gly","Glycine","C2H5NO2","Cytosol","C00037"]
["electron","Electron","e","Cytosol","C05359"]
["dnad","Deamino-NAD+","C21H27N6O15P2","Cytosol","C00857"]
["gln","L-Glutamine","C5H10N2O3","Cytosol","C00064"]
["n2","Nitrogen","N2","Cytosol","C00697"]
["cba","Carbonic acid","H2CO3","Cytosol","C01353"]
["nh4","Ammonia ion","NH4","Cytosol","C01342"]
["fad","Flavin adenine dinucleotide","C27H33N9O15P2","Cytosol","C00016"]
["fadh2","Reduced Flavin adenine dinucleotide","C27H35N9O15P2","Cytosol","C01352"]
["h_e","Hydron ext","H","Extracellular","C00080"]
["pratp","Phosphoribosyl ATP","C15H25N5O20P4","Cytosol","C02739"]
["pramp","Phosphoribosyl-AMP","C15H23N5O14P2","Cytosol","C02741"]
["prfa","Phosphoribosyl-formimino-AICAR-P","C15H25N5O15P2","Cytosol","C04896"]
["prufa","Phosphoribulosyl-formimino-AICAR-P","C15H25N5O15P2","Cytosol","C04916"]
["ig3p","Imidazole glycerol 3P","C6H11N2O6P","Cytosol","C04666"]
["iacp","Imidazol acetol P","C6H9N2O5P","Cytosol","C01267"]
["hislp","L-Histidinol phosphate","C6H12N3O4P","Cytosol","C01100"]
["hisl","L-Histidinol","C6H11N3O","Cytosol","C00860"]
["hisal","L-Histidinal","C6H9N3O","Cytosol","C01929"]
["his","L-Histidine","C6H9N3O2","Cytosol","C00135"]
["aicar","1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide","C9H15N4O8P","Cytosol","C04677"]
["4mop","4-Methyl-2-oxopentanoate","C6H10O3","Cytosol","C00233"]
["mbcoa","3-Methylbutanoyl-CoA","C26H44N7O17P3S","Cytosol","C02939"]
["leu","L-Leucine","C6H13NO2","Cytosol","C00123"]
["val","L-Valine","C5H11NO2","Cytosol","C00183"]
["2oival","3-Methyl-2-oxobutanoic acid","C5H8O3","Cytosol","C00141"]
["mpcoa","2-Methylpropanoyl-CoA","C25H42N7O17P3S","Cytosol","C00630"]
["ile","L-Isoleucine","C6H13NO2","Cytosol","C00407"]
["3mop","(S)-3-Methyl-2-oxopentanoic acid","C6H10O3","Cytosol","C00671"]
["s2mbcoa","(S)-2-Methylbutanoyl-CoA","C26H44N7O17P3S","Cytosol","C15980"]
["emm","D-erythro-3-Methylmalate","C5H8O5","Cytosol","C06032"]
["2hethpp","2-(alpha-Hydroxyethyl)thiamine diphosphate","C14H23N4O8P2S","Cytosol","C05125"]
["2ahbut","(S)-2-Aceto-2-hydroxybutanoate","C6H10O4","Cytosol","C06006"]
["thpp","Thiamin diphosphate","C12H19N4O7P2S","Cytosol","C00068"]
["3h3mop","(R)-3-Hydroxy-3-methyl-2-oxopentanoate","C6H10O4","Cytosol","C14463"]
["23h3mop","(R)-2,3-Dihydroxy-3-methylpentanoate","C6H12O4","Cytosol","C06007"]
["alac-S","(S)-2-Acetolactate","C5H8O4","Cytosol","C06010"]
["hmoa","3-Hydroxy-3-methyl-2-oxobutanoic acid","C5H8O4","Cytosol","C04181"]
["23dhmb","(R)-2,3-Dihydroxy-3-methylbutanoate","C5H10O4","Cytosol","C04272"]
["r2mm","(R)-2-Methylmalate","C5H8O5","Cytosol","C02612"]
["2sipmal","Isopropylmalate","C7H12O5","Cytosol","C02504"]
["2ipmal","2-Isopropylmaleate","C7H10O4","Cytosol","C02631"]
["2r3sipmal","(2R,3S)-3-Isopropylmalate","C7H12O5","Cytosol","C04411"]
["2ip3os","(2S)-2-Isopropyl-3-oxosuccinate","C7H10O5","Cytosol","C04236"]
["2mm","2-Methylmaleate","C5H6O4","Cytosol","C02226"]
["mbecoa","2-Methylbut-2-enoyl-CoA","C26H42N7O17P3S","Cytosol","C03345"]
["3h2mbcoa","(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA","C26H44N7O18P3S","Cytosol","C04405"]
["maacoa","2-Methylacetoacetyl-CoA","C26H42N7O18P3S","Cytosol","C03344"]
["ala","L-Alanine","C3H7NO2","Cytosol","C00041"]
["pram","5-Phosphoribosylamine","C5H12NO7P","Cytosol","C03090"]
["citr","L-Citrulline","C6H13N3O3","Cytosol","C00327"]
["asp","L-Aspartate","C4H7NO4","Cytosol","C00049"]
["args5p","N-(L-Arginino)succinate","C10H18N4O6","Cytosol","C03406"]
["arg","L-Arginine","C6H14N4O2","Cytosol","C00062"]
["asp-d","D-Aspartate","C4H7NO4","Cytosol","C00402"]
["asn","L-Asparagine","C4H8N2O3","Cytosol","C00152"]
["cdpdg","CDP-diacylglycerol","C14H19N3O15P2R2","Cytosol","C00269"]
["cmp","Cytidine-5'-monophosphate","C9H14N3O8P","Cytosol","C00055"]
["ps","Phosphatidylserine","C8H12NO10PR2","Cytosol","C02737"]
["ophser","O-Phospho-L-homoserine","C4H10NO6P","Cytosol","C01102"]
["thr","L-Threonine","C4H9NO3","Cytosol","C00188"]
["hser","L-Homoserine","C4H9NO3","Cytosol","C00263"]
["asp4sa","L-Aspartate 4-semialdehyde","C4H7NO3","Cytosol","C00441"]
["4pasp","4-Phospho-L-aspartate","C4H8NO7P","Cytosol","C03082"]
["igp","Indoleglycerol phosphate","C11H14NO6P","Cytosol","C03506"]
["trp","L-Tryptophan","C11H12N2O2","Cytosol","C00078"]
["dplr","Dihydrolipoylprotein; [H Protein]-dihydrolipoyllysine","C8H16NOS2R","Cytosol","C02972"]
["lprtn","Lipoylprotein","C8H14NOS2R","Cytosol","C02051"]
["3phpyr","3-Phosphonooxypyruvate","C3H5O7P","Cytosol","C03232"]
["3pser","O-Phospho-L-serine","C3H8NO6P","Cytosol","C01005"]
["cys","L-Cysteine","C3H7NO2S","Cytosol","C00097"]
["mpyr","Mercaptopyruvate","C3H4O3S","Cytosol","C00957"]
["dlglu","DL-Glutamate","C5H9NO4","Cytosol","C00302"]
["cysteate","L-Cysteate","C3H7NO5S","Cytosol","C00506"]
["3slala","3-Sulfino-L-alanine","C3H7NO4S","Cytosol","C00606"]
["3sfpyr","3-Sulfinylpyruvate","C3H4O5S","Cytosol","C05527"]
["3slac","3-Sulfolactate","C3H6O6S","Cytosol","C16069"]
["sahc","S-Adenosyl-L-homocysteine","C14H20N6O5S","Cytosol","C00021"]
["adn","Adenosine","C10H13N5O4","Cytosol","C00212"]
["hcys","L-Homocysteine","C4H9NO2S","Cytosol","C00155"]
["5mthg_e","5-Methyltetrahydropteroyltri-L-glutamate ext","C30H39N9O12","Extracellular","C04489"]
["mthg_e","Tetrahydropteroyltri-L-glutamate ext","C29H37N9O12","Extracellular","C04144"]
["dna","Deoxyribonucleic acid","C10H17O8PR2(C5H8O5PR)n","Cytosol","C00039"]
["dna5mc","DNA 5-methylcytosine","C10H16N3O7P(C5H8O5PR)n(C5H8O5PR)n","Cytosol","C02967"]
["sama","S-Adenosylmethioninamine","C14H23N6O3S","Cytosol","C01137"]
["5mta","5'-Methylthioadenosine","C11H15N5O3S","Cytosol","C00170"]
["ade","Adenine","C5H5N5","Cytosol","C00147"]
["mtr1p","S-Methyl-5-thio-D-ribose 1-phosphate; S-Methyl-5-thio-alpha-D-ribose 1-phosphate; S-Methyl-5-thio-5-deoxy-D-ribose 1-phosphate","C6H13O7PS","Cytosol","C04188"]
["lct","L-cystathionine","C3H7NO4S","Cytosol","C00606"]
["srhc","S-Ribosyl-L-homocysteine","C9H17NO6S","Cytosol","C03539"]
["dhptdn","(4S)-4,5-Dihydroxypentan-2,3-dione","C5H8O4","Cytosol","C11838"]
["23dpa","L-2,3-Dihydrodipicolinate","C7H7NO4","Cytosol","C03340"]
["tdpa","2,3,4,5-Tetrahydrodipicolinate","C7H9NO4","Cytosol","C03972"]
["s26dap","N-Succinyl-LL-2,6-diaminoheptanedioate","C11H18N2O7","Cytosol","C04421"]
["sdaop","N-Succinyl-2-L-amino-6-oxoheptanedioate","C11H15NO8","Cytosol","C04462"]
["26dap","LL-2,6-Diaminoheptanedioate","C7H14N2O4","Cytosol","C00666"]
["M26daP","meso-2,6-Diaminoheptanedioate; meso-2,6-Diaminopimelate; meso-2,6-Diaminopimelic acid; meso-Diaminoheptanedioate","C7H14N2O4","Cytosol","C00680"]
["lys","L-Lysine","C6H14N2O2","Cytosol","C00047"]
["hmisc","Homoisocitrate","C7H10O7","Cytosol","C05662"]
["btc","(Z)-But-1-ene-1,2,4-tricarboxylate","C7H8O6","Cytosol","C04002"]
["36dahx","(3S)-3,6-Diaminohexanoate","C6H14N2O2","Cytosol","C01142"]
["hbtc","(R)-2-Hydroxybutane-1,2,4-tricarboxylate","C7H10O7","Cytosol","C01251"]
["spmd","Spermidine","C7H19N3","Cytosol","C00315"]
["spermn","Spermine","C10H26N4","Cytosol","C00750"]
["cbp","Carbamoyl phosphate","CH4NO5P","Cytosol","C00169"]
["orn","L-Ornithine","C5H12N2O2","Cytosol","C00077"]
["crtn","Creatinine","C4H7N3O","Cytosol","C00791"]
["mhdt","N-Methylhydantoin; N-Methylimidazolidine-2,4-dione","C4H6N2O2","Cytosol","C02565"]
["agm","Agmatine","C5H14N4","Cytosol","C00179"]
["aglu","N-Acetyl-L-glutamate","C7H11NO5","Cytosol","C00624"]
["aglup","N-Acetyl-L-glutamate 5-phosphate","C7H12NO8P","Cytosol","C04133"]
["agsa","N-Acetyl-L-glutamate 5-semialdehyde","C7H11NO4","Cytosol","C01250"]
["nacorn","N-Acetylornithine","C7H14N2O3","Cytosol","C00437"]
["e4hglu","L-erythro-4-Hydroxyglutamate","C5H9NO5","Cytosol","C05947"]
["hoxglu","D-4-Hydroxy-2-oxoglutarate","C5H6O6","Cytosol","C05946"]
["ptrc","Putrescine","C4H12N2","Cytosol","C00134"]
["urea","Urea","CH4N2O","Cytosol","C00086"]
["pro","L-Proline","C5H9NO2","Cytosol","C00148"]
["tyr","L-Tyrosine","C9H11NO3","Cytosol","C00082"]
["tyrmn","Tyramine","C8H11NO","Cytosol","C00483"]
["dhphe","3,4-Dihydroxy-L-phenylalanine; L-Dopa; 3-Hydroxy-L-tyrosine; L-beta-(3,4-Dihydroxyphenyl)alanine; Levodopa; Dihydroxy-L-phenylalanine","C9H11NO4","Cytosol","C00355"]
["dpmn","Dopamine","C8H11NO2","Cytosol","C03758"]
["dhpeg","3,4-Dihydroxyphenylethyleneglycol","C8H10O4","Cytosol","C05576"]
["dhma","3,4-Dihydroxymandelaldehyde","C8H8O4","Cytosol","C05577"]
["Nmtyr","N-Methyltyramine","C9H13NO","Cytosol","C02442"]
["hrdn","Hordenine","C10H15NO","Cytosol","C06199"]
["phe","L-Phenylalanine","C9H11NO2","Cytosol","C00079"]
["ppyr","Phenylpyruvate","C9H8O3","Cytosol","C00166"]
["pac","Phenylacetic acid","C8H8O2","Cytosol","C07086"]
["phaccoa","Phenylacetyl-CoA; Phenylacetyl coenzyme A","C29H42N7O17P3S","Cytosol","C00582"]
["3dhq","3-Dehydroquinate","C7H10O6","Cytosol","C00944"]
["3dsk","3-Dehydroshikimate","C7H8O5","Cytosol","C02637"]
["skm","Shikimate","C7H10O5","Cytosol","C00493"]
["shk3p","Shikimate 3-phosphate","C7H11O8P","Cytosol","C03175"]
["5cpsk","5-O-(1-Carboxyvinyl)-3-phosphoshikimate","C10H13O10P","Cytosol","C01269"]
["chrs","Chorismate","C10H10O6","Cytosol","C00251"]
["anth","Anthranilate","C7H7NO2","Cytosol","C00108"]
["npran","N-(5-Phospho-D-ribosyl)anthranilate; N-(5-Phospho-beta-D-ribosyl)anthranilate; N-(5-Phosphoribosyl)anthranilic acid","C12H16NO9P","Cytosol","C04302"]
["cpad5p","1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate","C12H16NO9P","Cytosol","C01302"]
["indole","Indole","C8H7N","Cytosol","C00463"]
["prph","Prephenate","C10H10O6","Cytosol","C00254"]
["agnt","L-Arogenate","C10H13NO5","Cytosol","C00826"]
["dkfp","6-Deoxy-5-ketofructose 1-phosphate","C6H11O8P","Cytosol","C16848"]
["addth","2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid","C7H13NO5","Cytosol","C16850"]
["hpap_e","Hydroxypyruvaldehyde phosphate ext","C3H5O6P","Extracellular","C16849"]
["mglyx","Methylglyoxal","C3H4O2","Cytosol","C00546"]
["f1p","D-Fructose 1-phosphate","C6H13O9P","Cytosol","C01094"]
["glyald","D-Glyceraldehyde","C3H6O3","Cytosol","C00577"]
["trnaasnyl","L-Asparaginyl-tRNA(Asn)","C14H23N2O12PR2(C5H8O6PR)n","Cytosol","C03402"]
["trnaasn","tRNA(Asn)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01637"]
["5a4ic","5-Amino-4-imidazolecarboxyamide","C4H6N4O","Cytosol","C04051"]
["gua","Guanine","C5H5N5O","Cytosol","C00242"]
["capri","5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole","C9H14N3O9P","Cytosol","C15667"]
["cair","1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate","C9H14N3O9P","Cytosol","C04751"]
["ditp"," 2'-Deoxyinosine-5'-triphosphate","C10H15N4O13P3","Cytosol","C01345"]
["disnp","2'-Deoxyinosine 5'-phosphate","C10H13N4O7P","Cytosol","C06196"]
["imp","Inosinic acid","C10H13N4O8P","Cytosol","C00130"]
["prfica","1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide","C10H15N4O9P","Cytosol","C04734"]
["itp","Inosine monophosphate","C10H15N4O14P3","Cytosol","C00081"]
["dgtp","Deoxyguanosine triphosphate","C10H16N5O13P3","Cytosol","C00286"]
["dgmp","Deoxyguanosine monophosphate","C10H14N5O7P","Cytosol","C00362"]
["xtp","Xanthosine 5'-triphosphate","C10H15N4O15P3","Cytosol","C00700"]
["xmp","Xanthosine 5'-phosphate","C10H13N4O9P","Cytosol","C00655"]
["idp","Inosine diphosphate","C10H14N4O11P2","Cytosol","C00104"]
["dgdp","2'-Deoxyguanosine 5'-diphosphate","C10H15N5O10P2","Cytosol","C00361"]
["dadp","2'-Deoxyadenosine 5'-diphosphate","C10H15N5O9P2","Cytosol","C00206"]
["datp","2'-Deoxyadenosine 5'-triphosphate","C10H16N5O12P3","Cytosol","C00131"]
["didp"," 2'-Deoxyinosine-5'-diphosphate","C10H14N4O10P2","Cytosol","C01344"]
["dcamp","N6-(1,2-Dicarboxyethyl)-AMP","C14H18N5O11P","Cytosol","C03794"]
["camp","3',5'-Cyclic AMP","C10H12N5O6P","Cytosol","C00575"]
["cgmp","3',5'-Cyclic GMP","C10H12N5O7P","Cytosol","C00942"]
["gar","5'-Phosphoribosylglycinamide","C7H15N2O8P","Cytosol","C03838"]
["rthio","Thioredoxin","C10H14N4O4S2R4","Cytosol","C00342"]
["thrds","Thioredoxin disulfide","C10H12N4O4S2R4","Cytosol","C00343"]
["dg","Deoxyguanosine","C10H13N5O4","Cytosol","C00330"]
["fthf","10-Formyltetrahydrofolate","C20H23N7O7","Cytosol","C00234"]
["fgar","5'-Phosphoribosyl-N-formylglycinamide","C8H15N2O9P","Cytosol","C04376"]
["gsn","Guanosine","C10H13N5O5","Cytosol","C00387"]
["xtsn","Xanthosine","C10H12N4O6","Cytosol","C01762"]
["insn","Inosine","C10H12N4O5","Cytosol","C00294"]
["damp","2'-Deoxyadenosine 5'-phosphate","C10H14N5O6P","Cytosol","C00360"]
["dadsn","Deoxyadenosine","C10H13N5O3","Cytosol","C00559"]
["fgam","2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine","C8H16N3O8P","Cytosol","C04640"]
["air","Aminoimidazole ribotide","C8H14N3O7P","Cytosol","C03373"]
["saicar","1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole","C13H19N4O12P","Cytosol","C04823"]
["tpp","Triphosphate","P3H5O10","Cytosol","C00536"]
["cbasp","N-Carbamoyl-L-aspartate","C5H8N2O5","Cytosol","C00438"]
["ctp","Cytidine 5'-triphosphate","C9H16N3O14P3","Cytosol","C00063"]
["utp","Uridine 5'-triphosphate","C9H15N2O15P3","Cytosol","C00075"]
["dctp","Deoxycytidine 5'-triphosphate","C9H16N3O13P3","Cytosol","C00458"]
["dutp","2'-Deoxyuridine 5'-triphosphate","C9H15N2O14P3","Cytosol","C00460"]
["orot5p","Orotidine 5'-phosphate","C10H13N2O11P","Cytosol","C01103"]
["orot","Orotate; Orotic acid; Uracil-6-carboxylic acid","C5H4N2O4","Cytosol","C00295"]
["udp","Uridine 5'-diphosphate","C9H14N2O12P2","Cytosol","C00015"]
["cdp","Cytidine 5'-diphosphate","C9H15N3O11P2","Cytosol","C00112"]
["dcdp","2'-Deoxycytidine diphosphate","C9H15N3O10P2","Cytosol","C00705"]
["dudp","2'-Deoxyuridine 5'-diphosphate","C9H14N2O11P2","Cytosol","C01346"]
["dtdp","Deoxythymidine 5'-diphosphate","C10H16N2O11P2","Cytosol","C00363"]
["dttp","Deoxythymidine triphosphate","C10H17N2O14P3","Cytosol","C00459"]
["ump","Uridine monophosphate","C9H13N2O9P","Cytosol","C00105"]
["dump","Deoxyuridine monophosphate","C9H13N2O8P","Cytosol","C00365"]
["dcmp","Deoxycytidine monophosphate","C9H14N3O7P","Cytosol","C00239"]
["dtmp","Thymidine 5'-phosphate","C10H15N2O8P","Cytosol","C00364"]
["dhf","Dihydrofolate","C19H21N7O6","Cytosol","C00415"]
["uri","Uridine","C9H12N2O6","Cytosol","C00299"]
["cytdn","Cytidine","C9H13N3O5","Cytosol","C00475"]
["dc","Deoxycytidine","C9H13N3O4","Cytosol","C00881"]
["thymd","Thymidine; Deoxythymidine","C10H14N2O5","Cytosol","C00214"]
["ura","Uracil","C4H4N2O2","Cytosol","C00106"]
["thym","Thymine","C5H6N2O2","Cytosol","C00178"]
["2dr1p","2-Deoxy-D-ribose 1-phosphate","C5H11O7P","Cytosol","C00672"]
["duri","Deoxyuridine","C9H12N2O5","Cytosol","C00526"]
["csn","Cytosine","C4H5N3O","Cytosol","C00380"]
["mcsn","5-Methylcytosine","C5H7N3O","Cytosol","C02376"]
["doroa","(S)-Dihydroorotate","C5H6N2O4","Cytosol","C00337"]
["afapdrp","2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one","C10H16N5O9P","Cytosol","C15563"]
["daprap","2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one","C9H16N5O8P","Cytosol","C01304"]
["25adrpn","2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one","C9H18N5O8P","Cytosol","C18910"]
["fmnh2","Reduced flavin mononucleotide","C17H23N4O9P","Cytosol","C01847"]
["fmn","Flavin mononucleotide","C17H21N4O9P","Cytosol","C00061"]
["pht","O-Phospho-4-hydroxy-L-threonine","C4H10NO7P","Cytosol","C06055"]
["4hlt","4-Hydroxy-L-threonine","C4H9NO4","Cytosol","C06056"]
["aclact","2Acetolactate","C5H8O4","Cytosol","C00900"]
["dhmbn","2,3-Dihydroxy-3-methylbutanoate","C5H10O4","Cytosol","C04039"]
["pant-R","(R)-Pantoate","C6H12O4","Cytosol","C00522"]
["2dhp","2-Dehydropantoate","C6H10O4","Cytosol","C00966"]
["pptn","(R)-4-Phosphopantoate","C6H13O7P","Cytosol","C18911"]
["4ppan","D-4'-Phosphopantothenate","C9H18NO8P","Cytosol","C03492"]
["4ppncys","(R)-4'-Phosphopantothenoyl-L-cysteine","C12H23N2O9PS","Cytosol","C04352"]
["pan4p","Pantetheine 4'-phosphate","C11H23N2O7PS","Cytosol","C01134"]
["dpcoa","Dephospho-CoA","C21H35N7O13P2S","Cytosol","C00882"]
["pim_e","Pimelate ext","C7H12O4","Extracellular","C02656"]
["pim","Pimelate","C7H12O4","Extracellular","C02656"]
["pmcoa","Pimeloyl-CoA","C28H46N7O19P3S","Cytosol","C01063"]
["8aonn","8-Amino-7-oxononanoate","C9H17NO3","Cytosol","C01092"]
["amob","S-Adenosyl-4-methylthio-2-oxobutanoate","C15H20N5O6S","Cytosol","C04425"]
["dann","7,8-Diaminononanoate","C9H20N2O2","Cytosol","C01037"]
["dtbt","Dethiobiotin","C10H18N2O3","Cytosol","C01909"]
["h2s","Hydrogen sulfide","H2S","Cytosol","C00283"]
["btn","Biotin","C10H16N2O3S","Cytosol","C00120"]
["btamp","Biotinyl-5'-AMP","C20H28N7O9PS","Cytosol","C05921"]
["apoc","Apo-[carboxylase]","C7H13N3O2R2","Cytosol","C06249"]
["hcarb","Holo-[carboxylase]","C17H27N5O4SR2","Cytosol","C06250"]
["ahdt","2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate","C9H16N5O13P3","Cytosol","C04895"]
["pythp","6-Pyruvoyltetrahydropterin","C9H11N5O3","Cytosol","C03684"]
["uppg1","Uroporphyrinogen I","C40H44N4O16","Cytosol","C05766"]
["copp1","Coproporphyrinogen I","C36H44N4O8","Cytosol","C05768"]
["oxygen","Oxygen","O2","Cytosol","C00007"]
["fe2","Fe2+; Fe(II); Ferrous ion; Iron(2+)","Fe","Cytosol","C14818"]
["fe3","Fe3+; Fe(III); Ferric ion; Iron(3+)","Fe","Cytosol","C14819"]
["5alev","5-Aminolevulinate","C5H9NO3","Cytosol","C00430"]
["ppbng","Porphobilinogen","C10H14N2O4","Cytosol","C00931"]
["hmbil","Hydroxymethylbilane","C40H46N4O17","Cytosol","C01024"]
["uppg3","Uroporphyrinogen III","C40H44N4O16","Cytosol","C01051"]
["cpp","Coproporphyrinogen III","C36H44N4O8","Cytosol","C03263"]
["pc2","Precorrin 2","C42H48N4O16","Cytosol","C02463"]
["trnaglu","tRNA(Glu)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01641"]
["glutrna","L-Glutamyl-tRNA(Glu)","C20H28N6O13PR(C5H8O6PR)n","Cytosol","C02987"]
["aoxp","(S)-4-Amino-5-oxopentanoate","C5H9NO3","Cytosol","C03741"]
["scl","Sirohydrochlorin","C42H46N4O16","Cytosol","C05778"]
["sheme","Siroheme","C42H44FeN4O16","Cytosol","C00748"]
["co+2","Cobalt ion","Co","Cytosol","C00175"]
["coshrdn","Cobalt-sirohydrochlorin","C42H44CoN4O16","Cytosol","C11538"]
["cof3","Cobalt-factor III","C43H46CoN4O16","Cytosol","C17401"]
["db4p","3,4-Dihydroxy-2-butanone 4-phosphate","C4H9O6P","Cytosol","C15556"]
["copre3","Cobalt-precorrin 3","C43H48CoN4O16","Cytosol","C11539"]
["copre4","Cobalt-precorrin 4","C44H50CoN4O16","Cytosol","C11540"]
["copre5a","Cobalt-precorrin 5A","C45H52CoN4O16","Cytosol","C16242"]
["copre5b","Cobalt-precorrin 5B","C43H50CoN4O16","Cytosol","C16243"]
["copre6","Cobalt-precorrin 6","C44H53CoN4O16","Cytosol","C11542"]
["codhpre6","Cobalt-dihydro-precorrin 6","C44H55CoN4O16","Cytosol","C11543"]
["copre7","Cobalt-precorrin 7","C45H57CoN4O16","Cytosol","C16244"]
["copre8","Cobalt-precorrin 8","C45H59CoN4O14","Cytosol","C11545"]
["cobya","Cobyrinate","C45H59CoN4O14","Cytosol","C05773"]
["co2dam","Cob(II)yrinate a,c diamide","C45H61CoN6O12","Cytosol","C06504"]
["pre3a","Precorrin 3A","C43H50N4O16","Cytosol","C05772"]
["dmlz","6,7-Dimethyl-8-(1-D-ribityl)lumazine","C13H18N4O6","Cytosol","C04332"]
["pre3b","Precorrin 3B","C43H50N4O17","Cytosol","C06406"]
["pre4","Precorrin 4","C44H52N4O17","Cytosol","C06407"]
["pre5","Precorrin 5","C45H54N4O17","Cytosol","C06416"]
["pre6a","Precorrin 6A","C44H54N4O16","Cytosol","C06320"]
["pre6b","Precorrin 6B","C44H56N4O16","Cytosol","C06319"]
["hybyr","Hydrogenobyrinate","C45H60N4O14","Cytosol","C06399"]
["hgbam","Hydrogenobyrinate a,c diamide","C45H62N6O12","Cytosol","C06503"]
["acobda","Adenosyl cobyrinate a,c diamide","C55H73CoN11O15","Cytosol","C06506"]
["acobh","Adenosyl cobyrinate hexaamide","C55H77CoN15O11","Cytosol","C06507"]
["apol","(R)-1-Aminopropan-2-ol","C3H9NO","Cytosol","C03194"]
["adocbi","Adenosyl cobinamide","C58H84CoN16O11","Cytosol","C06508"]
["applp","D-1-Aminopropan-2-ol O-phosphate","C3H10NO4P","Cytosol","C04122"]
["adocbip","Adenosyl cobinamide phosphate","C58H85CoN16O14P","Cytosol","C06509"]
["agdpcbi","Adenosine-GDP-cobinamide","C68H97CoN21O21P2","Cytosol","C06510"]
["rbz","Ribazole","C14H18N2O4","Cytosol","C05775"]
["VitB12","Cobamide coenzyme","C72H100CoN18O17P","Cytosol","C00194"]
["ribflv","Riboflavin","C17H20N4O6","Cytosol","C00255"]
["smtc","2-(sulfomethyl)thiazolidine-4-carboxylate","C5H7NO5S2","Cytosol","NA"]
["2secys","S-(2-sulfoethyl)cysteine","C5H10NO5S2","Cytosol","NA"]
["4abz","4-Aminobenzoate","C7H7NO2","Cytosol","C00568"]
["rfab","4-(Î²-D-ribofuranosyl)aminobenzene-5'-phosphate","C11H14NO7P","Cytosol","NA"]
["s-lac","(S)-Lactate","C3H6O3","Cytosol","C00186"]
["5aprau","5-Amino-6-(5'-phospho-D-ribitylamino)uracil","C9H17N4O9P","Cytosol","C04454"]
["nmn","Nicotinamide D-ribonucleotide","C11H15N2O8P","Cytosol","C00455"]
["dmbz","Dimethylbenzimidazole; 5,6-Dimethylbenzimidazole","C9H10N2","Cytosol","C03114"]
["pardb","N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole","C14H19N2O7P","Cytosol","C04778"]
["nic","Nicotinate","C6H5NO2","Cytosol","C00253"]
["co1dam","Cob(I)yrinate a,c diamide; Cob(I)yrinate diamide; Cob(I)yrinic acid a,c-diamide","C45H61CoN6O12","Cytosol","C06505"]
["pyr5p","pyridoxal 5'-phosphate","C8H10NO6P","Cytosol","C00018"]
["ni2","Nickel+2","Ni","Cytosol","C19609"]
["cof430","Coenzyme F430","C42H51N6NiO13","Cytosol","C05777"]
["1hydtc","1-Hydroxyhexane-1,2,6-tricarboxylate","C9H14O7","Cytosol","C16600"]
["2oxsub","2-Oxosuberate","C8H12O5","Cytosol","C16589"]
["7oxhep","7-Oxoheptanoic acid","C7H12O3","Cytosol","C16590 "]
["7mrhpt","7-Mercaptoheptanoic acid","C7H14O2S","Cytosol","C16593"]
["7merhthr","7-Mercaptoheptanoylthreonine","C11H21NO4S","Cytosol","C16594"]
["Pimeloylacp","Pimelyl-[acyl-carrier protein]","C7H11O3SR","Cytosol","C19845"]
["ACP","Acyl-carrier protein","HSR","Cytosol","C00229"]
["78dnpt3p","7,8-Dihydroneopterin 3'-triphosphate","C9H16N5O13P3","Cytosol","C04895"]
["dnptp","Dihydroneopterin phosphate","C9H14N5O7P","Cytosol","C05925"]
["dnpt","7,8-Dihydroneopterin","C9H13N5O4","Cytosol","C04874"]
["Glycald","Glycoaldehyde","C2H4O2","Cytosol","C00266"]
["2a4h78dnpt","2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine","C7H9N5O2","Cytosol","C01300"]
["78hptab5p","7,8-H2pterin-6-yl-methyl-4-(β-D-ribofuranosyl)aminobenzene 5'-phosphate","C18H19N6O8P","Cytosol","NA"]
["78dptr5p","7,8-H2pterin-6-ylmethyl-l-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate","C18H21N6O8P","Cytosol","NA"]
["78dptapr","7,8-H2pterin-6-ylmethyl-l-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate","C18H21N6O8P","Cytosol","NA"]
["78dptf5p","7,8-H2pterin-6-ylmethyl-l-(4-aminophenyl)-1-deoxy-5-[1-α -D- ribofuranosyl 5-phosphate]-D-ribitol","C23H29N6O12P","Cytosol","NA"]
["78dptftp","7,8-H2pterin-6-ylmethyl-l-(4-aminophenyl)-1-deoxy-5-[1-α -D- ribofuranosyl triphosphate]-D-ribitol","C23H29N6O18P3","Cytosol","NA"]
["2hydoxglu","(S)-2-Hydroxyglutarate","C5H8O5","Cytosol","C03196"]
["dm78dhmpt","demethylated 7,8-dihydromethanopterin","C28H34N6O16P","Cytosol","NA"]
["dhmpt","7,8-Dihydromethanopterin","C30H43N6O16P","Cytosol","C05927"]
["thr3p","L-Threonine O-3-phosphate","C4H10NO6P","Cytosol","C12147"]
["cPMP","Cyclic pyranopterin monophosphate","C10H14N5O8P","Cytosol","C18239"]
["mbpt","Molybdopterin","C10H14N5O6PS2","Cytosol","C05924"]
["ambpt","Adenylated molybdopterin","C20H26N10O12P2S2","Cytosol","C19848"]
["mobd","Molybdate","H2MoO4","Cytosol","C06232"]
["mocof","molybdenum cofactor","C10H12MoN5O8PS2","Cytosol","C18237"]
["nicrnt","Nicotinate D-ribonucleotide","C11H15NO9P","Cytosol","C01185"]
["rnam","N-Ribosylnicotinamide","C11H15N2O5","Cytosol","C03150"]
["nicrns","Nicotinate D-ribonucleoside","C11H14NO6","Cytosol","C05841"]
["quln","Quinolinate; Pyridine-2,3-dicarboxylate; Quinolinic acid; 2,3-Pyridinedicarboxylic acid","C7H5NO4","Cytosol","C03722"]
["iasp","Iminoaspartate","C4H5NO4","Cytosol","C05840"]
["4ahmmp","4-Amino-5-hydroxymethyl-2-methylpyrimidine","C6H9N3O","Cytosol","C01279"]
["4ampm","4-Amino-2-methyl-5-phosphomethylpyrimidine; 4-Amino-5-phosphomethyl-2-methylpyrimidine","C6H10N3O4P","Cytosol","C04556"]
["2mahmp","2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate","C6H11N3O7P2","Cytosol","C04752"]
["hemt","5-(2-Hydroxyethyl)-4-methylthiazole","C6H9NOS","Cytosol","C04294"]
["4mpetz","4-Methyl-5-(2-phosphoethyl)-thiazole","C6H10NO4PS","Cytosol","C04327"]
["thmmp","Thiamin monophosphate","C12H18N4O4PS","Cytosol","C01081"]
["mgdnt","Molybdopterin guanine dinucleotide","C20H22N10O15P2S2Mo","Cytosol","NA"]
["trnacys","tRNA(Cys)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01639"]
["pstrna","O-Phosphoseryl-tRNA(Cys)","C13H23NO15P2R2(C5H8O6PR)n","Cytosol","C17022"]
["cystrna","L-Cysteinyl-tRNA(Cys)","C18H26N6O11PSR(C5H8O6PR)n","Cytosol","C03125"]
["trnamet","tRNA(Met)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01647"]
["trnametyl","L-Methionyl-tRNA","C20H30N6O11PSR(C5H8O6PR)n","Cytosol","C02430"]
["trnaval","tRNA(Val)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01653"]
["valtrna","L-Valyl-tRNA(Val)","C20H30N6O11PR(C5H8O6PR)n","Cytosol","C02554"]
["trnaleu","tRNA(Leu)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01645"]
["trnaleucyl","L-Leucyl-tRNA","C21H32N6O11PR(C5H8O6PR)n","Cytosol","C02047"]
["trnaile","tRNA(Ile)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01644"]
["iletrna","L-Isoleucyl-tRNA(Ile)","C21H32N6O11PR(C5H8O6PR)n","Cytosol","C03127"]
["trnaglnyl","L-Glutamyl-tRNA(Gln)","C20H28N6O13PR(C5H8O6PR)n","Cytosol","C06112"]
["trnaglmn","Glutaminyl-tRNA","C20H29N7O12PR(C5H8O6PR)n","Cytosol","C02282"]
["trnalys","tRNA(Lys)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01646"]
["trnalysyl","L-Lysyl-tRNA","C16H29N2O11PR2(C5H8O6PR)n","Cytosol","C01931"]
["trnaarg","tRNA(Arg)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01636"]
["argtrna","L-Arginyl-tRNA(Arg)","C21H33N9O11PR(C5H8O6PR)n","Cytosol","C02163"]
["trnapro","tRNA(Pro)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01649"]
["protrna","L-Prolyl-tRNA(Pro)","C15H24NO11PR2(C5H8O6PR)n","Cytosol","C02702"]
["trnahis","tRNA(His)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01643"]
["histrna","L-Histidyl-tRNA(His)","C16H24N3O11PR2(C5H8O6PR)n","Cytosol","C02988"]
["trnaphe","tRNA(Phe)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01648"]
["phetrna","L-Phenylalanyl-tRNA(Phe)","C19H26NO11PR2(C5H8O6PR)n","Cytosol","C03511"]
["trnatyr","tRNA(Tyr)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C00787"]
["tyrtrna","L-Tyrosyl-tRNA(Tyr)","C24H30N6O12PR(C5H8O6PR)n","Cytosol","C02839"]
["trnatrp","tRNA(Trp)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01652"]
["trptrna","L-Tryptophanyl-tRNA(Trp)","C26H31N7O11PR(C5H8O6PR)n","Cytosol","C03512"]
["trnaala","tRNA(Ala)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01635"]
["trnaalanyl","L-Alanyl-tRNA","C13H22NO11PR2(C5H8O6PR)n","Cytosol","C00886"]
["trnaasp","tRNA(Asp)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01638"]
["asptrna","L-Aspartyl-tRNA(Asp)","C14H22NO13PR2(C5H8O6PR)n","Cytosol","C02984"]
["asntrna","L-Aspartyl-tRNA(Asn)","C14H22NO13PR2(C5H8O6PR)n","Cytosol","C06113"]
["trnagly","tRNA(Gly)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01642"]
["glytrna","Glycyl-tRNA(Gly)","C12H20NO11PR2(C5H8O6PR)n","Cytosol","C02412"]
["trnathr","tRNA(Thr)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01651"]
["thrtrna","L-Threonyl-tRNA(Thr)","C14H24NO12PR2(C5H8O6PR)n","Cytosol","C02992"]
["trnaser","tRNA(Ser)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C01650"]
["sertrna","L-Seryl-tRNA(Ser)","C13H22NO12PR2(C5H8O6PR)n","Cytosol","C02553"]
["trnasec","tRNA(Sec)","C10H17O10PR2(C5H8O6PR)n","Cytosol","C16636"]
["trnaseryl","L-Seryl-tRNA(Sec)","C13H22NO12PR2(C5H8O6PR)n","Cytosol","C06481"]
["actn-R","(R)-Acetoin","C4H8O2","Cytosol","C00810"]
["trnagln","tRNA(Gln)","C15H21N5O10PR(C5H8O6PR)n","Cytosol","C01640"]
["metsela","Methylselenic acid","CH4O2Se","Cytosol","C18902"]
["mthsel","Methaneselenol","CH4Se","Cytosol","C05703"]
["selt","Selenite","SeO3","Cytosol","C05684"]
["seld","Selenide","H2Se","Cytosol","C01528"]
["shcys","Selenohomocysteine","C4H9NO2Se","Cytosol","C05698"]
["semth","L-Selenomethionine","C5H11NO2Se","Cytosol","C05335"]
["selp","Selenophosphoric acid","H3PO3Se","Cytosol","C05172"]
["trnapseryl","O-Phosphoseryl-tRNA(Sec)","C13H23NO15P2R2(C5H8O6PR)n","Cytosol","C16638"]
["trnaselcys","L-Selenocysteinyl-tRNA(Sec)","C13H22NO11PSeR2(C5H8O6PR)n","Cytosol","C06482"]
["cadv","Cadaverine","C5H14N2","Cytosol","C01672"]
["apcad","Aminopropylcadaverine","C8H21N3","Cytosol","C16565"]
["trnaselmet","Selenomethionyl-tRNA(Met)","C20H30N6O11PSeR(C5H8O6PR)n","Cytosol","C05336"]
["hmgcoa","(S)-3-Hydroxy-3-methylglutaryl-CoA","C27H44N7O20P3S","Cytosol","C00356"]
["mev-R","(R)-Mevalonate; Mevalonic acid; 3,5-Dihydroxy-3-methylvaleric acid","C6H12O4","Cytosol","C00418"]
["5pmev","(R)-5-Phosphomevalonate","C6H13O7P","Cytosol","C01107"]
["ipdp","Isopentenyl diphosphate","C5H12O7P2","Cytosol","C00129"]
["dmpp","Dimethylallyl diphosphate","C5H12O7P2","Cytosol","C00235"]
["grdp","Geranyl diphosphate","C10H20O7P2","Cytosol","C00341"]
["ttfdp","trans,trans-Farnesyl diphosphate","C15H28O7P2","Cytosol","C00448"]
["ggdp","Geranylgeranyl diphosphate","C20H36O7P2","Cytosol","C00353"]
["tcudp","di-trans,poly-cis-Undecaprenyl diphosphate","C55H92O7P2","Cytosol","C04574"]
["5dpmev","(R)-5-Diphosphomevalonate","C6H14O10P2","Cytosol","C01143"]
["tcpl","trans-3-Chloro-2-propene-1-ol","C3H5ClO","Cytosol","C06611"]
["claald","trans-1,3-Dichloropropene; trans-3-Chloroallyl chloride","C3H4Cl2","Cytosol","C06609"]
["ccpl","cis-3-Chloro-2-propene-1-ol","C3H5ClO","Cytosol","C06612"]
["ccald","cis-3-Chloroallyl aldehyde","C3H3ClO","Cytosol","C16348"]
["actyn","Acetylene","C2H2","Cytosol","C01548"]
["c2h4","Ethylene","C2H4","Cytosol","C06547"]
["24dnt","2,4-Diamino-6-nitrotoluene","C7H9N3O2","Cytosol","C16396"]
["dhamt","2,4-Diamino-6-hydroxylaminotoluene","C7H11N3O","Cytosol","C16399"]
["hmnapth","1-Hydroxymethylnaphthalene","C11H10O","Cytosol","C14089"]
["napthah","1-Naphthaldehyde","C11H8O","Cytosol","C14090"]
["napthm","(2-Naphthyl)methanol","C11H10O","Cytosol","C02909"]
["naptal","2-Naphthaldehyde","C11H8O","Cytosol","C14099"]
["aacoa","Acetoacetyl-CoA; Acetoacetyl coenzyme A; 3-Acetoacetyl-CoA","C25H40N7O18P3S","Cytosol","C00332"]
["actn","Acetyl adenylate","C12H16N5O8P","Cytosol","C05993"]
["gam6p","D-Glucosamine 6-phosphate","C6H14NO8P","Cytosol","C00352"]
["gam1p","D-Glucosamine 1-phosphate","C6H14NO8P","Cytosol","C06156"]
["nagn1p","N-Acetyl-alpha-D-glucosamine 1-phosphate","C8H16NO9P","Cytosol","C04501"]
["uacgam","UDP-N-acetyl-D-glucosamine","C17H27N3O17P2","Cytosol","C00043"]
["acmana","N-Acetyl-D-mannosamine","C8H15NO6","Cytosol","C00645"]
["uacmam","UDP-N-acetyl-D-mannosamine","C17H27N3O17P2","Cytosol","C01170"]
["uacmau","UDP-N-acetyl-D-mannosaminouronate","C17H25N3O18P2","Cytosol","C06240"]
["itcn","Itaconate","C5H6O4","Cytosol","C00490"]
["itcncoa","Itaconyl-CoA","C26H40N7O19P3S","Cytosol","C00531"]
["man6p","D-Mannose 6-phosphate","C6H13O9P","Cytosol","C00275"]
["man1p","D-Mannose 1-phosphate","C6H13O9P","Cytosol","C00636"]
["fc1p","L-Fuculose 1-phosphate","C6H13O8P","Cytosol","C01099"]
["lacald","(S)-Lactaldehyde","C3H6O2","Cytosol","C00424"]
["udp-glu","UDP-glucose","C15H24N2O17P2","Cytosol","C00029"]
["udpDgal","UDP-D-galactose","C15H24N2O17P2","Cytosol","C00052"]
["dgly","D-Glycerate","C3H6O4","Cytosol","C00258"]
["hpyr","Hydroxypyruvate","C3H4O4","Cytosol","C00168"]
["glyclt","Glycolate","C2H4O3","Cytosol","C00160"]
["glx","Glyoxylate","C2H2O3","Cytosol","C00048"]
["padn","Propionyladenylate","C13H18N5O8P","Cytosol","C05983"]
["prnoate","Propanoate","C3H6O2","Cytosol","C00163"]
["gdpman","GDP-mannose","C16H25N5O16P2","Cytosol","C00096"]
["cit","Citrate","C6H8O7","Cytosol","C00158"]
["cacn","cis-Aconitate","C6H6O6","Cytosol","C00417"]
["icit","Isocitrate","C6H8O7","Cytosol","C00311"]
["amy","Amylose; Amylose chain; (1,4-alpha-D-Glucosyl)n; (1,4-alpha-D-Glucosyl)n+1; (1,4-alpha-D-Glucosyl)n-1; 4-{(1,4)-alpha-D-Glucosyl}(n-1)-D-glucose; 1,4-alpha-D-Glucan","C6H10O5","Cytosol","C00718"]
["glycogen","Glycogen","C6H10O5","Cytosol","C00182"]
["bcoa","Butanoyl-CoA","C25H42N7O17P3S","Cytosol","C00136"]
["ohcoa","3-Oxohexanoyl-CoA","C27H44N7O18P3S","Cytosol","C05269"]
["glyc1p","sn-glycerol 1-phosphate","C3H9O6P","Cytosol","C00623"]
["ggrglyc1p","sn-3-O-(Geranylgeranyl)glycerol 1-phosphate","C23H41O6P","Cytosol","C04590"]
["tthcudp","tritrans,heptacis-Undecaprenyl diphosphate","C55H92O7P2","Cytosol","C19852"]
["23gglyc1p","2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate","C43H73O6P","Cytosol","C04638"]
["CDP-archaeol","CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol","C52H85N3O13P2","Cytosol","C18059"]
["co2_e","Carbon dioxide ext","CO2","Extracellular","C00011"]
["co+2_e","Cobalt ion ext","Co","Extracellular","C00175"]
["cys_e","L cysteine ext","C3H7NO2S","Extracellular","C00097"]
["h2s_e","Hydrogen sulfide ext","H2S","Extracellular","C00283"]
["h2_e","Hydrogen ext","H2","Extracellular","C00282"]
["ind3ac","Indole-3-acetate","C10H9NO2","Cytosol","C00954"]
["ind3ac_e","Indole-3-acetate ext","C10H9NO2","Extracellular","C00954"]
["Fe3_e","Ferric ion ext","Fe","Extracellular","C14819"]
["mg2_e","Magnesium ion ext","Mg","Extracellular","C00305"]
["mg2","Magnesium ion","Mg","Cytosol","C00305"]
["nh4_e","Ammonia ion ext","NH4","Extracellular","C01342"]
["ch4_e","Methane ext","CH4","Extracellular","C01438"]
["mo_e","Molybdenum ext","Mo","Extracellular","C00150"]
["mo","Molybdenum","Mo","Cytosol","C00150"]
["mobd_e","Molybdate ext","H2MoO4","Extracellular","C06232"]
["ni2_e","Nickel ion ext","Ni","Extracellular","C19609"]
["n2_e","Nitrogen ext","N2","Extracellular","C00697"]
["na_e","Sodium ion ext","Na","Extracellular","C01330"]
["pro_e","L-proline ext","C5H9NO2","Extracellular","C00148"]
["na","Sodium ion","Na","Cytosol","C01330"]
["selnt_e","Selenite ext","SeO3","Extracellular","C05684"]
["so3_e","Sulfite ext","H2SO3","Extracellular","C00094"]
["so4_e","Sulfate ext","H2SO4","Extracellular","C00059"]
["so4","Sulfate","H2SO4","Cytosol","C00059"]
["h2o_e","Water ext","H2O","Extracellular","C00001"]
["pi_e","Orthophosphate ext","H3PO4","Extracellular","C00009"]
["urea_e","Urea ext","CH4N2O","Extracellular","C00086"]
["mtr1p_e","S-Methyl-5-thio-D-ribose 1-phosphate ext","C6H13O7PS","Extracellular","C04188"]
["oxygen_e","Oxygen ext","O2","Extracellular","C00007"]
["acetate_e","Acetate ext","C2H4O2","Extracellular","C00033"]
["ala_e","L-Alanine ext","C3H7NO2","Extracellular","C00041"]
["fe2_e","Ferrous ion ext","Fe","Extracellular","C14818"]
["hco3_e","Bicarbonate ext","HCO3","Extracellular","C00288"]
["csn_e","Cytosine ext","C4H5N3O","Extracellular","C00380"]
["w_e","Tungsten ext","W","Extracellular","C00753"]
["w","Tungsten","W","Cytosol","C00753"]
["xan_e","Xanthine ext","C5H4N4O2","Extracellular","C00385"]
["ura_e","Uracil ext","C4H4N2O2","Extracellular","C00106"]
["xan","Xanthine","C5H4N4O2","Cytosol","C00385"]
["dasn_e","5'-Deoxyadenosine ext","C10H13N5O3","Extracellular","C05198"]
["2plac_e","(2S)-2-Phospholactate ext","C3H7O6P","Extracellular","C19156"]
["btn_e","Biotin ext","C10H16N2O3S","Extracellular","C00120"]
["1hydtc_e","1-Hydroxyhexane-1,2,6-tricarboxylate ext","C9H14O7","Extracellular","C16600"]
["amob_e","S-Adenosyl-4-methylthio-2-oxobutanoate ext","C15H20N5O6S","Extracellular","C04425"]
["rbz_e","Ribazole ext","C14H18N2O4","Extracellular","C05775"]
["Glycald_e","Glycoaldehyde ext","C2H4O2","Extracellular","C00266"]
["lys_e","L-Lysine ext","C6H14N2O2","Extracellular","C00047"]
["nh3_e","Ammonia ext","NH3","Extracellular","C00014"]
["formate_e","Formate ext","CH2O2","Extracellular","C00058"]
["cd2","Cadmium","Cd","Cytosol","C01413"]
["cd2_e","Cadmium ext","Cd","Extracellular","C01413"]

{"sheet":"exchange reactions","index":2,"n_rows":49,"n_cols":2,"rows_kept":49,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Exchange reaction","Equation"]
["ammonia exchange","nh3_e <=>"]
["Sulfate exchange","so4_e <=>"]
["5-Methyltetrahydropteroyltri-L-glutamate exchange","5mthg_e <=>"]
["Hydrogen exchange","h2_e <=>"]
["Nitrogen exchange","n2_e <=>"]
["Hydrogen sulfide exchange","h2s_e <=>"]
["Urea exchange","urea_e <=>"]
["Indole3acetate transport","ind3ac_e <=>"]
["proline exchange","pro_e <=>"]
["S-Adenosyl-4-methylthio-2-oxobutanoate exchange","amob_e <=>"]
["biotin exchange","btn_e <=>"]
["Molybdate exchange","mobd_e <=>"]
["S-Methyl-5-thio-D-ribose 1-phosphate exchange","mtr1p_e <=>"]
["Alanine exchange","ala_e <=>"]
["(2S)-2-Phospholactate exchange","2plac_e <=>"]
["Tungstate exchange","w_e <=>"]
["Orthophosphate exchange","pi_e <=>"]
["uracil exchange","ura_e <=>"]
["pimelate exchange","pim <=>"]
["Hydroxypyruvaldehyde phosphate exchange","hpap_e <=>"]
["formate exchange","formate_e <=>"]
["cytosine exchange","csn_e <=>"]
["ribazole exchange","rbz_e <=>"]
["Nickel exchange","ni2_e <=>"]
["Biomass Formation","biomass_e <=>"]
["ammonium ion exchange","nh4_e <=>"]
["xanthine exchange","xan_e <=>"]
["water exchange","h2o_e <=>"]
["methane exchange","ch4_e <=>"]
["bicarbonate exchange","hco3_e <=>"]
["cobalt exchange","co+2_e <=>"]
["acetate exchange","acetate_e <=>"]
["1-Hydroxyhexane-1,2,6-tricarboxylate exchange","1hydtc_e <=>"]
["magnesium exchange","mg2_e <=>"]
["sodium exchange","na_e <=>"]
["lysine exchange","lys_e <=>"]
["5'-Deoxyadenosine exchange","dasn_e <=>"]
["Oxygen exchange","oxygen_e <=>"]
["Glycoaldehyde exchange","Glycald_e <=>"]
["Tetrahydropteroyltri-L-glutamate exchange","mthg_e <=>"]
["molybdenum ion exchange","mo_e <=>"]
["sulfite exchange","so3_e <=>"]
["Selenite exchange","selnt_e <=>"]
["Carbon dioxide exchange","co2_e <=>"]
["cysteine exchange","cys_e <=>"]
["proton exchange","h_e <=>"]
["ferric ion exchange","Fe3_e <=>"]
["ferrous ion exchange","fe2_e <=>"]

{"sheet":"References","index":3,"n_rows":19,"n_cols":2,"rows_kept":19,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
[1,"Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., and Tanabe, M.; KEGG for integration and interpretation of large-scale molecular datasets. Nucleic Acids Res. 2012, 40, D109-D114."]
[2,"Kanehisa, M. and Goto, S.; KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 2000, 28, 27-30."]
[3,"Caspi, R., Altman, T., Dreher, K., Fulcher, C. A., Subhraveti, P., Keseler, I. M., ... and Karp, P. D. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Research, 2012, 40(D1), D742-D753."]
[4,"Porat, I., Sieprawska-Lupa, M., Teng, Q., Bohanon, F. J., White, R. H. and Whitman, W. B. Biochemical and genetic characterization of an early step in a novel pathway for the biosynthesis of aromatic amino acids and p-aminobenzoic acid in the archaeon Methanococcus maripaludis. Molecular Microbiology, 2006, 62, 1117–1131."]
[5,"Yu, J.-P., J. Ladapo, and W. B. Whitman. Pathway of glycogen metabolism in Methanococcus maripaludis. J. Bacteriol. 1994, 176, 325–332"]
[6,"Marion Graupner and Robert H. White.Methanococcus jannaschii Generates l-Proline by Cyclization of l-Ornithine.J Bacteriol. 2001, 183(17), 5203–5205"]
[7,"Robert P. Hausinger, William H. Orme-Johnson, and Christopher Walsh. Factor 390 chromophores: phosphodiester between AMP or GMP and methanogenic factor 420. Biochemistry, 1985, 24 (7), 1629-1633\n"]
[8,"Namboori, Seema C., and David E. Graham. \"Acetamido sugar biosynthesis in the Euryarchaea.\" Journal of bacteriology 2008, 190(8), 2987-2996."]
[9,"Liu, Yuchen, Robert H. White, and William B. Whitman. \"Methanococci use the diaminopimelate aminotransferase (DapL) pathway for lysine biosynthesis.\" Journal of bacteriology. 2010, 192(13), 3304-3310."]
[10,"White, Robert H. \"L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.\" Biochemistry, 2004, 43(23), 7618-7627."]
[11,"Buchenau, B. & Thauer, R. K.Tetrahydrofolate-specific enzymes in Methanosarcina barkeri and growth dependence of this methanogenic archaeon on olic acid or p-aminobenzoic acid. Arch Microbiol, im Druck 2004"]
[12,"Worrell, V. E., and D. P. Nagle Jr. \"Folic acid and pteroylpolyglutamate contents of archaebacteria.\" Journal of bacteriology. 1988, 170(9), 4420-4423."]
[13,"Ragsdale, Stephen W. \"Biocatalytic One‐Carbon Conversion.\" Encyclopedia of Catalysis. 2002."]
[14,"Liu, Yuchen. Adaptations of Methanococcus maripaludis to its unique lifestyle. 2010, 175-185"]
[15,"Strassman, Murray, and Louis N. Ceci. Enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis. Biochemical and biophysical research communications. 1964, 14, 262."]
[16,"Shieh, J. S., and WILLIAM B. Whitman. Pathway of acetate assimilation in autotrophic and heterotrophic methanococci. Journal of bacteriology. 1987, 169(11), 5327-5329."]
[17,"Feist, Adam M., et al. \"Modeling methanogenesis with a genome-scale metabolic reconstruction of Methanosarcina barkeri.\" Molecular systems biology. 2006,  2(1)."]
[18,"Howell, David M., et al. \"Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.\" Journal of bacteriology. 2000, 182(17), 5013-5016."]
[19,"Koga, Y., & Morii, H. Biosynthesis of ether-type polar lipids in archaea and evolutionary considerations. Microbiology and Molecular Biology Reviews. 2007, 71(1), 97-120."]

{"sheet":"Minimal media","index":4,"n_rows":15,"n_cols":4,"rows_kept":15,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Minimal media components"]
["Abbreviation","Metabolite name",null,"Comments"]
["h2","Hydrogen",null,"presence of formate reduce hydrogen uptake significantly"]
["h2s","Hydrogen sulfide",null,"h2s uptake significantly reduced when cysteine was added in the medium as sulfur souce"]
["nh4","ammonium ion",null,"nitrogen and alanine can be used as alternate nitrogen source"]
["pi","Orthophosphate"]
["so3","Sulfite"]
["co2","Carbon dioxide",null,"Presence of formate, pyruvate and alanine greatly reduced co2 uptake"]
["h","hydron"]
["fe2","Iron (II)",null,"Iron transport via channel"]
["h2o","water"]
["ni+2","Nickel"]
["co+2","Cobalt ion"]
["W","Tungsten",null,"required for formylmethanofuran dehydrogenase activity"]
["Na","Sodium ion",null,"sodium/hydrogen exchange pump"]

{"sheet":"Dead end metabolites","index":5,"n_rows":164,"n_cols":3,"rows_kept":164,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Metabolite abv.","Metabolite name","Reaction Participation"]
["tthcudp","tritrans,heptacis-Undecaprenyl diphosphate","only produced"]
["hybyr","Hydrogenobyrinate","only consumed"]
["4hlt","4-Hydroxy-L-threonine","only produced"]
["trnaile","tRNA(Ile)","only consumed"]
["trnatyr","tRNA(Tyr)","only consumed"]
["mbcoa","3-Methylbutanoyl-CoA","only produced"]
["rib-D","D-Ribose","only consumed"]
["idp","Inosine diphosphate","only consumed"]
["uppg1","Uroporphyrinogen I","only consumed"]
["mcsn","5-Methylcytosine","only consumed"]
["cd2","Cadmium","only consumed"]
["trnasec","tRNA(Sec)","only consumed"]
["cit","Citrate","only produced"]
["asptrna","L-Aspartyl-tRNA(Asp)","only produced"]
["apoc","Apo-[carboxylase]","only consumed"]
["xan","Xanthine","only produced"]
["trnaleu","tRNA(Leu)","only consumed"]
["napthm","(2-Naphthyl)methanol","only consumed"]
["pyr5p","pyridoxal 5'-phosphate","only produced"]
["uacmau","UDP-N-acetyl-D-mannosaminouronate","only produced"]
["udpDgal","UDP-D-galactose","only produced"]
["3slala","3-Sulfino-L-alanine","only consumed"]
["didp"," 2'-Deoxyinosine-5'-diphosphate","only consumed"]
["gua","Guanine","only produced"]
["trnagly","tRNA(Gly)","only consumed"]
["nicrns","Nicotinate D-ribonucleoside","only produced"]
["actyn","Acetylene","only consumed"]
["s-lac","(S)-Lactate","only consumed"]
["pre3b","Precorrin 3B","only consumed"]
["pre3a","Precorrin 3A","only produced"]
["agnt","L-Arogenate","only consumed"]
["sertrna","L-Seryl-tRNA(Ser)","only produced"]
["mgdnt","Molybdopterin guanine dinucleotide","only produced"]
["ACP","Acyl-carrier protein","only produced"]
["cysteate","L-Cysteate","only consumed"]
["nic","Nicotinate","only produced"]
["mhdt","N-Methylhydantoin; N-Methylimidazolidine-2,4-dione","only produced"]
["ahdt","2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate","only consumed"]
["e4hglu","L-erythro-4-Hydroxyglutamate","only consumed"]
["tyrtrna","L-Tyrosyl-tRNA(Tyr)","only produced"]
["argtrna","L-Arginyl-tRNA(Arg)","only produced"]
["fc1p","L-Fuculose 1-phosphate","only consumed"]
["apcad","Aminopropylcadaverine","only produced"]
["histrna","L-Histidyl-tRNA(His)","only produced"]
["trnatrp","tRNA(Trp)","only consumed"]
["valtrna","L-Valyl-tRNA(Val)","only produced"]
["shcys","Selenohomocysteine","only consumed"]
["napthah","1-Naphthaldehyde","only produced"]
["gsn","Guanosine","only produced"]
["cgmp","3',5'-Cyclic GMP","only produced"]
["asp-d","D-Aspartate","only produced"]
["cacn","cis-Aconitate","only consumed"]
["mg2","Magnesium ion","only produced"]
["tyrmn","Tyramine","only produced"]
["dc","Deoxycytidine","only produced"]
["5a4ic","5-Amino-4-imidazolecarboxyamide","only produced"]
["Pimeloyl-[acp]","Pimelyl-[acyl-carrier protein]","only consumed"]
["tcpl","trans-3-Chloro-2-propene-1-ol","only consumed"]
["dgly","D-Glycerate","only consumed"]
["ccpl","cis-3-Chloro-2-propene-1-ol","only consumed"]
["thrtrna","L-Threonyl-tRNA(Thr)","only produced"]
["w","Tungsten","only produced"]
["xtp","Xanthosine 5'-triphosphate","only consumed"]
["crtn","Creatinine","only consumed"]
["hbtc","(R)-2-Hydroxybutane-1,2,4-tricarboxylate","only produced"]
["ohcoa","3-Oxohexanoyl-CoA","only produced"]
["dadsn","Deoxyadenosine","only produced"]
["rnam","N-Ribosylnicotinamide","only produced"]
["dhamt","2,4-Diamino-6-hydroxylaminotoluene","only produced"]
["hrdn","Hordenine","only produced"]
["man6p","D-Mannose 6-phosphate","only consumed"]
["trnaglmn","Glutaminyl-tRNA","only produced"]
["mthsel","Methaneselenol","only produced"]
["lacald","(S)-Lactaldehyde","only produced"]
["duri","Deoxyuridine","only consumed"]
["dmbz","Dimethylbenzimidazole; 5,6-Dimethylbenzimidazole","only consumed"]
["iletrna","L-Isoleucyl-tRNA(Ile)","only produced"]
["claald","trans-1,3-Dichloropropene; trans-3-Chloroallyl chloride","only produced"]
["dna5mc","DNA 5-methylcytosine","only produced"]
["cadv","Cadaverine","only consumed"]
["sdaop","N-Succinyl-2-L-amino-6-oxoheptanedioate","only produced"]
["hoxglu","D-4-Hydroxy-2-oxoglutarate","only produced"]
["phaccoa","Phenylacetyl-CoA; Phenylacetyl coenzyme A","only produced"]
["hcarb","Holo-[carboxylase]","only produced"]
["bcoa","Butanoyl-CoA","only consumed"]
["dhptdn","(4S)-4,5-Dihydroxypentan-2,3-dione","only produced"]
["etoh","Ethanol","only consumed"]
["ind3ac","Indole-3-acetate","only consumed"]
["dhphe","3,4-Dihydroxy-L-phenylalanine; L-Dopa; 3-Hydroxy-L-tyrosine; L-beta-(3,4-Dihydroxyphenyl)alanine; Levodopa; Dihydroxy-L-phenylalanine","only consumed"]
["pre6a","Precorrin 6A","only consumed"]
["ccald","cis-3-Chloroallyl aldehyde","only produced"]
["en6lip","Enzyme N6-(dihydrolipoyl)lysine","only consumed"]
["glyclt","Glycolate","only consumed"]
["tcudp","di-trans,poly-cis-Undecaprenyl diphosphate","only produced"]
["gdpman","GDP-mannose","only produced"]
["ps","Phosphatidylserine","only produced"]
["mo","Molybdenum","only produced"]
["e6lip","en6liplys","only produced"]
["3sfpyr","3-Sulfinylpyruvate","only produced"]
["cba","Carbonic acid","only consumed"]
["trptrna","L-Tryptophanyl-tRNA(Trp)","only produced"]
["naptal","2-Naphthaldehyde","only produced"]
["hmisc","Homoisocitrate","only consumed"]
["trnaalanyl","L-Alanyl-tRNA","only produced"]
["glx","Glyoxylate","only produced"]
["c2h4","Ethylene","only produced"]
["pythp","6-Pyruvoyltetrahydropterin","only produced"]
["trnaser","tRNA(Ser)","only consumed"]
["disnp","2'-Deoxyinosine 5'-phosphate","only produced"]
["Nmtyr","N-Methyltyramine","only consumed"]
["cpp","Coproporphyrinogen III","only produced"]
["trnaleucyl","L-Leucyl-tRNA","only produced"]
["dlglu","DL-Glutamate","only produced"]
["3slac","3-Sulfolactate","only produced"]
["protrna","L-Prolyl-tRNA(Pro)","only produced"]
["trnaala","tRNA(Ala)","only consumed"]
["trnahis","tRNA(His)","only consumed"]
["trnaval","tRNA(Val)","only consumed"]
["pht","O-Phospho-4-hydroxy-L-threonine","only consumed"]
["pre6b","Precorrin 6B","only produced"]
["f1p","D-Fructose 1-phosphate","only consumed"]
["phetrna","L-Phenylalanyl-tRNA(Phe)","only produced"]
["trnathr","tRNA(Thr)","only consumed"]
["camp","3',5'-Cyclic AMP","only produced"]
["damp","2'-Deoxyadenosine 5'-phosphate","only consumed"]
["insn","Inosine","only produced"]
["xtsn","Xanthosine","only produced"]
["lprtn","Lipoylprotein","only produced"]
["trnalysyl","L-Lysyl-tRNA","only produced"]
["btc","(Z)-But-1-ene-1,2,4-tricarboxylate","only produced"]
["trnaasp","tRNA(Asp)","only consumed"]
["trnaarg","tRNA(Arg)","only consumed"]
["itcn","Itaconate","only consumed"]
["glyald","D-Glyceraldehyde","only produced"]
["copp1","Coproporphyrinogen I","only produced"]
["actn","Acetyl adenylate","only consumed"]
["mpcoa","2-Methylpropanoyl-CoA","only produced"]
["adocbi","Adenosyl cobinamide","only produced"]
["trnapro","tRNA(Pro)","only consumed"]
["pre5","Precorrin 5","only produced"]
["36dahx","(3S)-3,6-Diaminohexanoate","only produced"]
["metsela","Methylselenic acid","only consumed"]
["hmnapth","1-Hydroxymethylnaphthalene","only consumed"]
["hpyr","Hydroxypyruvate","only produced"]
["dplr","Dihydrolipoylprotein; [H Protein]-dihydrolipoyllysine","only consumed"]
["asntrna","L-Aspartyl-tRNA(Asn)","only consumed"]
["cdpdg","CDP-diacylglycerol","only consumed"]
["trnalys","tRNA(Lys)","only consumed"]
["dhma","3,4-Dihydroxymandelaldehyde","only produced"]
["trnaphe","tRNA(Phe)","only consumed"]
["dhpeg","3,4-Dihydroxyphenylethyleneglycol","only consumed"]
["trnametyl","L-Methionyl-tRNA","only produced"]
["dpmn","Dopamine","only produced"]
["trnagln","tRNA(Gln)","only consumed"]
["uri","Uridine","only produced"]
["apol","(R)-1-Aminopropan-2-ol","only consumed"]
["glytrna","Glycyl-tRNA(Gly)","only produced"]
["itcncoa","Itaconyl-CoA","only produced"]
["acmana","N-Acetyl-D-mannosamine","only produced"]
["dg","Deoxyguanosine","only produced"]
["trnaselmet","Selenomethionyl-tRNA(Met)","only produced"]
["pac","Phenylacetic acid","only consumed"]
["24dnt","2,4-Diamino-6-nitrotoluene","only consumed"]

{"sheet":"gene or reaction essentiality","index":6,"n_rows":284,"n_cols":8,"rows_kept":284,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["List of essential and non essential genes obtained after Single gene deletion analysis",{"$nulls":5},"List of reactions critical for production of biomass"]
["List of essential genes","List of non essential genes",{"$nulls":4},"Name of essential reactions","Associated enzyme"]
["MMP1077","MMP1296",{"$nulls":4},"R1","phosphoglucomutase"]
["MMP1532","MMP1487",{"$nulls":4},"R4","phosphoglycerate kinase"]
["MMP0396","MMP0112",{"$nulls":4},"R5","phosphoglycerate mutase"]
["MMP1504","MMP1439",{"$nulls":4},"R6","phosphopyruvate hydratase"]
["MMP1505","MMP0598",{"$nulls":4},"R8","pyruvate synthase"]
["MMP1506","MMP1605",{"$nulls":4},"R11","glucose-6-phosphate isomerase"]
["MMP1507","MMP1332",{"$nulls":4},"R12","fructose-bisphosphatase"]
["MMP1295","MMP0802",{"$nulls":4},"R13","fructose-bisphosphate aldolase"]
["MMP0317","MMP0945",{"$nulls":4},"R14","triose-phosphate isomerase"]
["MMP0293","MMP0148",{"$nulls":4},"R27","fumarate hydratase"]
["MMP0686","MMP1274",{"$nulls":4},"R28","succinate---CoA ligase (ADP-forming)"]
["MMP0687","MMP0253",{"$nulls":4},"R29","2-oxoglutarate synthase"]
["MMP0325","MMP0340",{"$nulls":4},"R31","ribulose-phosphate 3-epimerase"]
["MMP0130","MMP0341",{"$nulls":4},"R33","ribose-5-phosphate isomerase"]
["MMP1548","MMP0645",{"$nulls":4},"R34","ribose-phosphate diphosphokinase"]
["MMP0955","MMP0418",{"$nulls":4},"R35","6-phospho-3-hexuloisomerase"]
["MMP1105","MMP1448",{"$nulls":4},"R36","transketolase"]
["MMP0003","MMP1449",{"$nulls":4},"R37","transaldolase"]
["MMP0305","MMP1450",{"$nulls":4},"R38","transketolase"]
["MMP0306","MMP1451",{"$nulls":4},"R39","3-hexulose-6-phosphate synthase"]
["MMP1315","MMP1452",{"$nulls":4},"R40","phosphopentomutase"]
["MMP1316","MMP1453",{"$nulls":4},"R41","ferredoxin hydrogenase;energy-converting hydrogenase"]
["MMP1687","MMP1454",{"$nulls":4},"R43","formylmethanofuran---tetrahydromethanopterin N-formyltransferase"]
["MMP1114","MMP1455",{"$nulls":4},"R45","methenyltetrahydromethanopterin cyclohydrolase"]
["MMP1189","MMP1456",{"$nulls":4},"R46"," F420-dependent methylenetetrahydromethanopterin dehydrogenase"]
["MMP0410","MMP1457",{"$nulls":4},"R47","7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase"]
["MMP1270","MMP1458",{"$nulls":4},"R48","2-phospho-L-lactate transferase"]
["MMP1113","MMP1459",{"$nulls":4},"R49","coenzyme F420-0:L-glutamate ligase"]
["MMP1115","MMP1460",{"$nulls":4},"R50","coenzyme F420-1:gamma-L-glutamate ligase"]
["MMP1308","MMP1461",{"$nulls":4},"R51","2-phospho-L-lactate guanylyltransferase"]
["MMP0070","MMP1462",{"$nulls":4},"R52","coenzyme gamma-F420-2:alpha-L-glutamate ligase"]
["MMP0200","MMP1463",{"$nulls":4},"R53","5,10-methylenetetrahydromethanopterin reductase"]
["MMP0508","MMP1464",{"$nulls":4},"R54","acetyl-CoA decarbonylase/synthase complex"]
["MMP0509","MMP1465",{"$nulls":4},"R55","tetrahydromethanopterin S-methyltransferase"]
["MMP0510","MMP1466",{"$nulls":4},"R56","coenzyme-B sulfoethylthiotransferase"]
["MMP0511","MMP1467",{"$nulls":4},"R57","CoB CoM heterodisulfide reductase;coenzyme F420-non-reducing hydrogenase"]
["MMP0512","MMP0400",{"$nulls":4},"R58","phosphosulfolactate synthase"]
["MMP0965","MMP0940",{"$nulls":4},"R59","2-phosphosulfolactate phosphatase"]
["MMP1244","MMP1049",{"$nulls":4},"R62","sulfopyruvate decarboxylase"]
["MMP1245","MMP1073",{"$nulls":4},"R63","carbonate dehydratase"]
["MMP1246","MMP1074",{"$nulls":4},"R64","spontaneous reaction"]
["MMP1247","MMP1153",{"$nulls":4},"R65","5,10-methylenetetrahydromethanopterin:glycine hydroxymethyltransferase"]
["MMP1248","MMP1469",{"$nulls":4},"R66","carbon-monoxide dehydrogenase (acceptor)"]
["MMP1249","MMP1621",{"$nulls":4},"R67","formylmethanofuran dehydrogenase"]
["MMP1691","MMP1622",{"$nulls":4},"R68","Hydrogenases"]
["MMP1609","MMP1623",{"$nulls":4},"R69","NAD+ synthase"]
["MMP1191","MMP1624",{"$nulls":4},"R71","glutamate---ammonia ligase"]
["MMP0372","MMP1625",{"$nulls":4},"R76","H+-transporting two-sector ATPase"]
["MMP0056","MMP1626",{"$nulls":4},"R79","ATP phosphoribosyltransferase"]
["MMP0057","MMP1627",{"$nulls":4},"R80","phosphoribosyl-ATP diphosphatase"]
["MMP0876","MMP1628",{"$nulls":4},"R81","phosphoribosyl-AMP cyclohydrolase"]
["MMP0404","MMP1629",{"$nulls":4},"R82","1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase"]
["MMP0937","MMP0127",{"$nulls":4},"R83","imidazoleglycerol-phosphate dehydratase"]
["MMP0117","MMP1716",{"$nulls":4},"R84","histidinol-phosphate transaminase"]
["MMP0170","MMP1502",{"$nulls":4},"R85","histidinol dehydrogenase"]
["MMP0058","MMP1503",{"$nulls":4},"R86","histidinol dehydrogenase"]
["MMP0980","MMP0984",{"$nulls":4},"R87","histidinol-phosphatase"]
["MMP0981","MMP0985",{"$nulls":4},"R88","histidine biosynthesis"]
["MMP0983","MMP0147",{"$nulls":4},"R90","branched-chain-amino-acid transaminase"]
["MMP1560","MMP0853",{"$nulls":4},"R91","branched-chain-amino-acid transaminase"]
["MMP1561","MMP0856",{"$nulls":4},"R93","branched-chain-amino-acid transaminase"]
["MMP1562","MMP0857",{"$nulls":4},"R96","acetolactate synthase"]
["MMP1563","MMP0858",{"$nulls":4},"R97","ketol-acid reductoisomerase"]
["MMP1564","MMP0859",{"$nulls":4},"R98","ketol-acid reductoisomerase"]
["MMP1565","MMP0860",{"$nulls":4},"R99","dihydroxy-acid dehydratase"]
["MMP1566","MMP0049",{"$nulls":4},"R104","3-isopropylmalate dehydratase"]
["MMP1567","MMP1067",{"$nulls":4},"R105","3-isopropylmalate dehydratase"]
["MMP1555","MMP1277",{"$nulls":4},"R106","3-isopropylmalate dehydrogenase"]
["MMP1556","MMP0219",{"$nulls":4},"R107","acetolactate synthase"]
["MMP1557","MMP1690",{"$nulls":4},"R108","2-isopropylmalate synthase"]
["MMP1558","MMP0417",{"$nulls":4},"R109","3-isopropylmalate dehydrogenase"]
["MMP1559","MMP1083",{"$nulls":4},"R115","alanine dehydrogenase"]
["MMP0825","MMP1722",{"$nulls":4},"R116","amidophosphoribosyltransferase"]
["MMP1053","MMP1271",{"$nulls":4},"R117","argininosuccinate synthase"]
["MMP1054","MMP1272",{"$nulls":4},"R118","argininosuccinate lyase"]
["MMP1154","MMP1273",{"$nulls":4},"R121","aspartate transaminase"]
["MMP1155","MMP1018",{"$nulls":4},"R123","asparagine synthase (glutamine-hydrolysing)"]
["MMP1697","MMP0739",{"$nulls":4},"R127","threonine synthase"]
["MMP0823","MMP0081",{"$nulls":4},"R128","homoserine kinase"]
["MMP1694","MMP1171",{"$nulls":4},"R131","aspartate kinase"]
["MMP0273","MMP0011",{"$nulls":4},"R134","phosphoserine transaminase"]
["MMP0161","MMP1398",{"$nulls":4},"R135","phosphoserine phosphatase"]
["MMP1133","MMP0381",{"$nulls":4},"R136","phosphoglycerate dehydrogenase"]
["MMP0411","MMP1480",{"$nulls":4},"R137","aspartate-semialdehyde dehydrogenase"]
["MMP1689","MMP0861",{"$nulls":4},"R143","adenosylhomocysteinase"]
["MMP1299","MMP0153",{"$nulls":4},"R144","5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase"]
["MMP1349","MMP0869",{"$nulls":4},"R146","methionine adenosyltransferase"]
["MMP0918","MMP0096",{"$nulls":4},"R147","adenosylmethionine decarboxylase"]
["MMP1206","MMP0131",{"$nulls":4},"R149","cystathionine gamma-lyase"]
["MMP1038","MMP1717",{"$nulls":4},"R150","cystathionine beta-lyase"]
["MMP1039","MMP0160",{"$nulls":4},"R154","dihydrodipicolinate synthase"]
["MMP1040","MMP0314",{"$nulls":4},"R159","LL-diaminopimelate aminotransferase"]
["MMP1041","MMP0715",{"$nulls":4},"R160","diaminopimelate epimerase"]
["MMP1042","MMP0609",{"$nulls":4},"R161","diaminopimelate decarboxylase"]
["MMP1043","MMP0214",{"$nulls":4},"R166","spermidine synthase"]
["MMP1044","MMP0128",{"$nulls":4},"R167","ornithine carbamoyltransferase"]
["MMP1045","MMP1064",{"$nulls":4},"R169","arginine decarboxylase"]
["MMP1046","MMP1051",{"$nulls":4},"R171","acetylglutamate kinase"]
["MMP0947","MMP1031",{"$nulls":4},"R172","N-acetyl-gamma-glutamyl-phosphate reductase"]
["MMP0051","MMP0882",{"$nulls":4},"R173","acetylornithine transaminase"]
["MMP0280","MMP1254",{"$nulls":4},"R174","glutamate N-acetyltransferase"]
["MMP0548","MMP0024",{"$nulls":4},"R176","agmatinase"]
["MMP1216","MMP0281",{"$nulls":4},"R177","spermidine synthase"]
["MMP0968","MMP1122",{"$nulls":4},"R179","glutamate-5-kinase"]
["MMP0132","MMP1426",{"$nulls":4},"R186","aspartate transaminase"]
["MMP0539","MMP0893",{"$nulls":4},"R188","3-Dehydroquinate hydro-lyase"]
["MMP0650","MMP1075",{"$nulls":4},"R189","shikimate 5-dehydrogenase"]
["MMP0654","MMP0680",{"$nulls":4},"R190","shikimate kinase"]
["MMP0318","MMP0327",{"$nulls":4},"R191","3-phosphoshikimate 1-carboxyvinyltransferase"]
["MMP0136","MMP0126",{"$nulls":4},"R192","chorismate synthase"]
["MMP1149","MMP1238",{"$nulls":4},"R195","anthranilate phosphoribosyltransferase"]
["MMP0142","MMP0119",{"$nulls":4},"R196","phosphoribosylanthranilate isomerase"]
["MMP0651","MMP1250",{"$nulls":4},"R197","indole-3-glycerol-phosphate synthase"]
["MMP1063","MMP0830",{"$nulls":4},"R200","chorismate mutase"]
["MMP1212","MMP1150",{"$nulls":4},"R202","prephenate dehydratase"]
["MMP1513","MMP1159",{"$nulls":4},"R205","2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase"]
["MMP1146","MMP1477",{"$nulls":4},"R206","3-dehydroquinate synthase II"]
["MMP0073","MMP1478",{"$nulls":4},"R210","adenine phosphoribosyltransferase\n"]
["MMP0013","MMP0028",{"$nulls":4},"R213","5-(carboxyamino)imidazole ribonucleotide mutase"]
["MMP1072","MMP0493",{"$nulls":4},"R215","IMP cyclohydrolase"]
["MMP1527","MMP0184",{"$nulls":4},"R225","adenylosuccinate synthase"]
["MMP0496","MMP0943",{"$nulls":4},"R226","adenylosuccinate lyase"]
["MMP0082","MMP1597",{"$nulls":4},"R229","phosphoribosylamine---glycine ligase"]
["MMP0080","MMP0103",{"$nulls":4},"R233","ribonucleoside-triphosphate reductase"]
["MMP0135","MMP1656",{"$nulls":4},"R235","phosphoribosylglycinamide formyltransferase"]
["MMP0295","MMP0037",{"$nulls":4},"R241","GMP synthase (glutamine-hydrolysing)"]
["MMP1702","MMP0230",{"$nulls":4},"R242","IMP dehydrogenase"]
["MMP1017","MMP0571",{"$nulls":4},"R244","ribonucleoside-triphosphate reductase"]
["MMP1002","MMP1066",{"$nulls":4},"R245","phosphoribosylformylglycinamidine synthase"]
["MMP1003","MMP1235",{"$nulls":4},"R246","phosphoribosylformylglycinamidine cyclo-ligase"]
["MMP0541","MMP1357",{"$nulls":4},"R247","phosphoribosylaminoimidazolesuccinocarboxamide synthase"]
["MMP1588","MMP0201",{"$nulls":4},"R248","adenylosuccinate lyase"]
["MMP1391","MMP0513",{"$nulls":4},"R249","5-(carboxyamino)imidazole ribonucleotide synthase"]
["MMP0920","MMP0545",{"$nulls":4},"R250","5-(carboxyamino)imidazole ribonucleotide mutase"]
["MMP0401","MMP1619",{"$nulls":4},"R251","guanylate kinase"]
["MMP1640","MMP1639",{"$nulls":4},"R254","nucleoside triphosphatase"]
["MMP1583","MMP1138",{"$nulls":4},"R255","aspartate carbamoyltransferase"]
["MMP0185","MMP1139",{"$nulls":4},"R260","orotate phosphoribosyltransferase"]
["MMP0576","MMP1124",{"$nulls":4},"R261","nucleoside-diphosphate kinase"]
["MMP0923","MMP0187",{"$nulls":4},"R263","carbamoyl-phosphate synthase (glutamine-hydrolysing)"]
["MMP1101","MMP0573",{"$nulls":4},"R266","nucleoside-diphosphate kinase"]
["MMP0917","MMP0326",{"$nulls":4},"R269","orotidine-5'-phosphate decarboxylase"]
["MMP1200","MMP0584",{"$nulls":4},"R272","UMP/CMP kinase"]
["MMP1584","MMP0697",{"$nulls":4},"R273","thioredoxin-disulfide reductase"]
["MMP0553","MMP1474",{"$nulls":4},"R274","dTMP kinase"]
["MMP1582","MMP0575",{"$nulls":4},"R276","thymidylate synthase"]
["MMP0897","MMP0946",{"$nulls":4},"R286","dihydroorotase"]
["MMP0063","MMP1265",{"$nulls":4},"R288","dihydroorotate dehydrogenase (fumarate)"]
["MMP0116","MMP1266",{"$nulls":4},"R289","ribonucleoside-triphosphate reductase"]
["MMP1585","MMP1510",{"$nulls":4},"R292","GTP cyclohydrolase Iia"]
["MMP1394","MMP1318",{"$nulls":4},"R293","2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase"]
["MMP0936","MMP1026",{"$nulls":4},"R296","FMN reductase (NADH)"]
["MMP0320","MMP0696",{"$nulls":4},"R301","2-dehydropantoate 2-reductase"]
["MMP1205","MMP1614",{"$nulls":4},"R302","pantoate kinase"]
["MMP1333","MMP1255",{"$nulls":4},"R303","4-phosphopantoate---beta-alanine ligase"]
["MMP1005","MMP1496",{"$nulls":4},"R306","phosphopantothenoylcysteine decarboxylase"]
["MMP1006","MMP0263",{"$nulls":4},"R307","pantetheine-phosphate adenylyltransferase"]
["MMP1007","MMP1592",{"$nulls":4},"R308","6-carboxyhexanoate---CoA ligase"]
["MMP1004","MMP0397",{"$nulls":4},"R309","8-amino-7-oxononanoate synthase"]
["MMP1008","MMP1616",{"$nulls":4},"R310","adenosylmethionine---8-amino-7-oxononanoate transaminase"]
["MMP0578","MMP0212",{"$nulls":4},"R311","dethiobiotin synthase"]
["MMP1514","MMP0414",{"$nulls":4},"R312","biotin synthase"]
["MMP1528","MMP0879",{"$nulls":4},"R318","porphobilinogen synthase"]
["MMP0006","MMP0613",{"$nulls":4},"R319","hydroxymethylbilane synthase"]
["MMP0145","MMP0904",{"$nulls":4},"R320","uroporphyrinogen-III synthase"]
["MMP0660","MMP0595",{"$nulls":4},"R322","uroporphyrinogen-III C-methyltransferase"]
["MMP0282","MMP1490",{"$nulls":4},"R323","glutamate---tRNA ligase"]
["MMP1310","MMP0002",{"$nulls":4},"R324","glutamyl-tRNA reductase"]
["MMP0283","MMP1345",{"$nulls":4},"R325","glutamate-1-semialdehyde 2,1-aminomutase"]
["MMP1432","MMP1094",{"$nulls":4},"R326","precorrin-2 dehydrogenase"]
["MMP0971","MMP1680",{"$nulls":4},"R327","sirohydrochlorin ferrochelatase"]
["MMP0392","MMP1076",{"$nulls":4},"R328","sirohydrochlorin cobaltochelatase"]
["MMP0227","MMP0357",{"$nulls":4},"R329","cobalt-factor II C20-methyltransferase"]
["MMP0123","MMP0705",{"$nulls":4},"R330","3,4-dihydroxy-2-butanone-4-phosphate synthase"]
["MMP0894","MMP0706",{"$nulls":4},"R331","precorrin-3B C17-methyltransferase"]
["MMP1445","MMP1372",{"$nulls":4},"R332","precorrin-4 C11-methyltransferase"]
["MMP0133","MMP1187",{"$nulls":4},"R333","cobalt-precorrin 5A hydrolase"]
["MMP0287","MMP1090",{"$nulls":4},"R334","cobalt-precorrin-5B (C1)-methyltransferase"]
["MMP0178","MMP0870",{"$nulls":4},"R335","precorrin-6A reductase"]
["MMP0179","MMP1220",{"$nulls":4},"R336","precorrin-6Y C5,15-methyltransferase (decarboxylating)"]
["MMP0540","MMP1292",{"$nulls":4},"R337","cobalt-precorrin-7 (C15)-methyltransferase [decarboxylating]"]
["MMP1373","MMP0886",{"$nulls":4},"R338","precorrin-8X methylmutase"]
["MMP0339","MMP0888",{"$nulls":4},"R339","cobyrinate a,c-diamide synthase"]
["MMP1104","MMP0889",{"$nulls":4},"R341","6,7-dimethyl-8-ribityllumazine synthase"]
["MMP1659","MMP1481",{"$nulls":4},"R347","adenosylcobyric acid synthase (glutamine-hydrolysing)"]
["MMP0079","MMP1482",{"$nulls":4},"R349","adenosylcobinamide-phosphate synthase"]
["MMP1492","MMP1483",{"$nulls":4},"R350","adenosylcobinamide-GDP ribazoletransferase"]
["MMP1013","MMP1484",{"$nulls":4},"R351","riboflavin synthase"]
["MMP1589","MMP1092",{"$nulls":4},"R353","ribose check"]
["MMP0602","MMP0110",{"$nulls":4},"R354","COM biosynthesis I"]
["MMP0626","MMP0198",{"$nulls":4},"R355","coenzyme M biosynthesis I"]
["MMP0385","MMP1183",{"$nulls":4},"R356","tetrahydromethanopterin biosynthesis"]
["MMP0959","MMP0196",{"$nulls":4},"R357","beta-ribofuranosylaminobenzene 5'-phosphate synthase"]
["MMP1034","MMP0108",{"$nulls":4},"R358","purine-nucleoside phosphorylase"]
["MMP0986","MMP0197",{"$nulls":4},"R359","dephospho-CoA kinase"]
["MMP1379","MMP1108",{"$nulls":4},"R360","F420-non-reducing hydrogenase"]
["MMP1009","MMP0711",{"$nulls":4},"R363","pyrimidine phosphatase"]
["MMP0439","MMP0065",{"$nulls":4},"R366","cob(II)yrinic acid a,c-diamide reductase"]
["MMP0405","MMP0068",{"$nulls":4},"R367","cob(I)yrinic acid a,c-diamide adenosyltransferase"]
["MMP1705","MMP0205",{"$nulls":4},"R368","adenosylcobinamide-phosphate guanylyltransferase"]
["MMP1348","MMP0507",{"$nulls":4},"R369","flavin biosynthesis II (archaea)"]
["MMP1259","MMP0514",{"$nulls":4},"R372","cobalt-precorrin 3 dehydrogenase"]
["MMP0672","MMP0975",{"$nulls":4},"R373","Enzyme unknown"]
["MMP0398","MMP1651",{"$nulls":4},"R374","Isopropylmalate/isohomocitrate dehydrogenase"]
["MMP1306","MMP0206",{"$nulls":4},"R375","Enzyme unknown"]
["MMP1606","MMP0506",{"$nulls":4},"R376","Enzyme unknown"]
["MMP1093","MMP0515",{"$nulls":4},"R377","Enzyme unknown"]
["MMP1575","MMP1650",{"$nulls":4},"R378","Enzyme unknown"]
["MMP1574","MMP0207",{"$nulls":4},"R380","GTP cyclohydrolase"]
["MMP0865","MMP0504",{"$nulls":4},"R381","metal dependent phosphohydrolase"]
["MMP1573","MMP1649",{"$nulls":4},"R382","metal dependent phosphohydrolase"]
["MMP1258","MMP0271",{"$nulls":4},"R383","dihydroneopterin aldolase"]
["MMP0872","MMP0220",{"$nulls":4},"R384","dihydropteroate synthase"]
["MMP0394","MMP0221",{"$nulls":4},"R385","THMPT synthesis 6"]
["MMP0966","MMP0100",{"$nulls":4},"R386","THMPT synthesis 7"]
["MMP1011","MMP0484",{"$nulls":4},"R387","THMPT synthesis 8"]
["MMP0088","MMP0587",{"$nulls":4},"R388","THMPT synthesis 9"]
["MMP0224","MMP0864",{"$nulls":4},"R389","THMPT synthesis 10"]
["MMP0089","MMP0707",{"$nulls":4},"R390","THMPT synthesis 11"]
["MMP0164","MMP0529",{"$nulls":4},"R391","THMPT synthesis 12"]
["MMP0319","MMP0663",{"$nulls":4},"R392","THMPT synthesis 13"]
["MMP0183","MMP1518",{"$nulls":4},"R393","Threonine kinase"]
["MMP0953","MMP0345",{"$nulls":4},"R394","threonine-phosphate decarboxylase"]
["MMP1662","MMP1095",{"$nulls":4},"R399","NAD+ kinase"]
["MMP1591","MMP1096",{"$nulls":4},"R401","nicotinamide-nucleotide adenylyltransferase"]
["MMP1203","MMP1097",{"$nulls":4},"R404","nicotinate-nucleotide diphosphorylase (carboxylating)"]
["MMP0599","MMP1098",{"$nulls":4},"R405","quinolinate synthase"]
["MMP1227","MMP1199",{"$nulls":4},"R408","dihydrofolate reductase"]
["MMP1221","MMP1099",{"$nulls":4},"R409","phosphoribosylglycinamide formyltransferase"]
["MMP0330","MMP1198",{"$nulls":4},"R418","2-dehydropantoate aldolase"]
["MMP0050","MMP0789",{"$nulls":4},"R419","O-phospho-L-serine tRNA ligase"]
["MMP1215","MMP0866",{"$nulls":4},"R420","O-phospho-L-seryl-tRNA:Cys-tRNA synthase"]
["MMP0938","MMP0867",{"$nulls":4},"R421","cysteine tRNA ligase"]
["MMP0180","MMP0868",{"$nulls":4},"R442","coenzyme F420 hydrogenase"]
["MMP0279","MMP1652",{"$nulls":4},"R454","hydroxymethylglutaryl-CoA reductase (NADPH)"]
["MMP1692","MMP1519",{"$nulls":4},"R455","mevalonate kinase"]
["MMP1696","MMP0689",{"$nulls":4},"R456","isopentenyl-diphosphate Delta-isomerase"]
["MMP1695","MMP0681",{"$nulls":4},"R457","dimethylallyltranstransferase"]
["MMP1693","MMP0849",{"$nulls":4},"R458","geranylgeranyl diphosphate synthase"]
["MMP0880","MMP1301",{"$nulls":4},"R459","(2E,6E)-farnesyl diphosphate synthase"]
["MMP0034","MMP0216",{"$nulls":4},"R461","phosphomevalonate kinase"]
["MMP1580",{"$nulls":5},"R462","diphosphomevalonate decarboxylase"]
["MMP1489",{"$nulls":5},"R469","methylglyoxal synthase"]
["MMP1578",{"$nulls":5},"R470","6-deoxy-5-ketofructose 1-phosphate synthase"]
["MMP0877",{"$nulls":5},"R472","acetyl-CoA C-acetyltransferase"]
["MMP1242",{"$nulls":5},"R474","pyruvate formate-lyase"]
["MMP0737",{"$nulls":5},"R489","formate dehydrogenase"]
["MMP0688",{"$nulls":5},"R492","UTP---glucose-1-phosphate uridylyltransferase"]
["MMP1240",{"$nulls":5},"R499","hydroxymethylglutaryl-CoA synthase"]
["MMP1060",{"$nulls":5},"R500","Oxalate decarboxylase"]
["MMP0083",{"$nulls":5},"R501","acetaldehyde dehydrogenase (acetylating)"]
["MMP0817",{"$nulls":5},"R507","glycogen synthase (UDPGlc)"]
["MMP0818",{"$nulls":5},"R512","phosphoglycerol geranylgeranyltransferase"]
["MMP0819",{"$nulls":5},"R514","geranylgeranylglycerol-phosphate geranylgeranyltransferase"]
["MMP0820",{"$nulls":5},"R515","CDP-archaeol synthase"]
["MMP1382",{"$nulls":5},"R516","Carbon dioxide transport"]
["MMP1383",{"$nulls":5},"R517","Cobalt ABC transporter"]
["MMP1384",{"$nulls":5},"R519","Hydrogen sulfide transport"]
["MMP1385",{"$nulls":5},"R520","Hydrogen transport"]
["MMP1337",{"$nulls":5},"R528","Methane transport"]
["MMP0087",{"$nulls":5},"R531","Nickel transport"]
["MMP1335",{"$nulls":5},"R536","Sulfite transport"]
["MMP0043",{"$nulls":5},"R538","Water transport"]
["MMP0045",{"$nulls":5},"R539","Orthophosphate transport"]
["MMP1358",{"$nulls":5},"R540","Urea transport"]
["MMP0138",{"$nulls":5},"R541","S-Methyl-5-thio-D-ribose 1-phosphate_transport"]
["MMP0139",{"$nulls":5},"R544","Alanine transport"]
["MMP1297",{"$nulls":5},"R545","Iron transport via channel"]
["MMP1298",{"$nulls":5},"R552","5'-Deoxyadenosine transport"]
["MMP1091",{"$nulls":5},"R553","(2S)-2-Phospholactate transport"]
["MMP1211",{"$nulls":5},"R555","1-Hydroxyhexane-1,2,6-tricarboxylate transport"]
["MMP1294",{"$nulls":5},"R556","S-Adenosyl-4-methylthio-2-oxobutanoate transport"]
["MMP0225",{"$nulls":5},"R557","Ribazole transport"]
["MMP0007",{"$nulls":5},"R558","Glycoaldehyde transport"]
["MMP1677",{"$nulls":5},"R562","Alanine transport via permease"]
["MMP0796",{"$nulls":5},"R564","Pimelate transport"]
["MMP0630",{"$nulls":5},"R565","Biomass Formation"]
[{"$nulls":6},"R566","DNA synthesis"]
[{"$nulls":6},"R567","Phospholipid synthesis"]
[{"$nulls":6},"R568","Protein synthesis"]
[{"$nulls":6},"R569","RNA synthesis"]
[{"$nulls":6},"R570","Soluble pools"]