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["Literature validation for predicted indications of 143 drugs with ATC"]
["cluster","drugs","ATC1","ATC2","ATC3","ATC4","PMID1(ATC1)","PMID2(ATC2)","PMID3(ATC3)","PMID4(ATC4)","Target(ATC1)","Target(ATC2)","Target(ATC3)","Target(ATC4)"]
[3,"azelaic acid","nervous","respiratory","antineoplastic",null,null,10362281,9125756,null,"akr1d1"]
[3,"phenylbutazone","nervous","respiratory","antineoplastic",null,22581725,13128683]
[3,"fenoprofen","nervous","respiratory","antineoplastic",null,22169772,327002]
[3,"propranolol","nervous","respiratory","antineoplastic",null,23451243,23045296,23045296]
[3,"hydroxychloroquine","nervous","respiratory","antineoplastic",null,20978875,23719253,22878749]
[3,"amifostine","nervous","respiratory","antineoplastic",null,15736415,21104159,21646919]
[3,"fenofibrate","nervous","respiratory","antineoplastic",null,1754977,15166256]
[4,"l-glutamine","nervous","cardiac",null,null,23360507,22977661]
[4,"clodronate","nervous","cardiac",null,null,23579773,19168432]
[4,"etidronic acid","nervous","cardiac",{"$nulls":6},"ptprs, atp6v1a"]
[4,"l-methionine","nervous","cardiac",null,null,"http://clinicaltrials.gov/ct2/show/NCT00348933?term=%22l-methionine%22and+%22nervous%22&rank=3","http://clinicaltrials.gov/ct2/show/NCT00284011?term=%22l-methionine%22and+%22cardiac%22&rank=1",null,null,"mtr, mtrr"]
[4,"l-cysteine","nervous","cardiac",null,null,2185543,12224824]
[4,"dicumarol","nervous","cardiac",{"$nulls":6},"vkorc1, nqo1"]
[4,"malathion","nervous","cardiac",null,null,17513201,16850888]
[4,"tolbutamide","nervous","cardiac",null,null,22028182,2504288]
[4,"chlorpropamide","nervous","cardiac",null,null,8928190,12222701]
[4,"dasatinib","nervous","cardiac",null,null,23548721,19734999]
[4,"nepafenac","nervous","cardiac",null,null,12769666,{"$nulls":4},"ptgs2, ptgs1"]
[5,"mifepristone","nervous","cardiac",null,null,20149549,"http://clinicaltrials.gov/ct2/show/NCT00004575?term=clotrimazole+and+cardiac&rank=1"]
[5,"clotrimazole","nervous","cardiac",null,null,15341525,16341233,null,null,""]
[5,"riboflavin","nervous","cardiac",null,null,2830700,22355488]
[6,"diethylpropion","nervous",null,null,null,18976683]
[6,"doxapram","nervous",null,null,null,4006308]
[6,"anastrozole","nervous",null,null,null,23712697]
[6,"tioconazole","nervous",{"$nulls":7},"cyp51a1"]
[6,"oxybutynin","nervous",null,null,null,21642736]
[6,"cyclobenzaprine","nervous",null,null,null,12764337]
[6,"ketotifen","nervous",null,null,null,9368705]
[6,"promethazine","nervous",null,null,null,12002730]
[6,"phentolamine","nervous",null,null,null,17497343]
[6,"toremifene","nervous",null,null,null,9685060]
[6,"oxaprozin","nervous",{"$nulls":7},"ptgs2, ptgs1"]
[6,"timolol","nervous",null,null,null,10604299,null,null,null,""]
[7,"tiotropium","digest","nervous",null,null,null,15947126,null,null,"chrm2"]
[7,"brompheniramine","digest","nervous",null,null,null,8933774,null,null,"chrm2"]
[7,"cyproheptadine","digest","nervous",null,null,null,"http://clinicaltrials.gov/ct2/show/NCT00066248?term=cyproheptadine+and+nervous&rank=1",null,null,"chrm2","htr2a, htr2c, chrm3, chrm2, chrm1"]
[7,"podofilox","digest","nervous",null,null,null,"http://clinicaltrials.gov/ct2/show/NCT00027846?term=podofilox+and+nervous&rank=1",null,null,"","tuba4a, top2a"]
[7,"chlorotrianisene","digest","nervous",{"$nulls":6},"","esr1"]
[7,"cyclopentolate","digest","nervous",null,null,3306268,"http://clinicaltrials.gov/ct2/show/NCT00748059?term=cyclopentolate+and+nervous&rank=1",null,null,null,"chrm1"]
[7,"tropicamide","digest","nervous",null,null,10420100,3253133]
[7,"alprostadil","digest","nervous",null,null,10913932,{"$nulls":4},"ptger2"]
[7,"bepridil","digest","nervous",null,null,2430441,{"$nulls":4},"cacna1h, calm2, calm3, calm1, cacna1a, pde1a, atp1a1, pde1b, cacna2d2"]
[7,"phenoxybenzamine","digest","nervous",null,null,12736183,12828843]
[8,"terazosin","digest","skin",null,null,10737914,10737915]
[8,"dapiprazole","digest","skin",null,null,14639139,{"$nulls":4},"adra1a"]
[8,"vecuronium","digest","skin",null,null,17846478]
[8,"erlotinib","digest","skin",null,null,23534992,"http://clinicaltrials.gov/ct2/show/NCT01059305?term=erlotinib+and+skin&rank=1"]
[8,"fenoterol","digest","skin",null,null,6254828,11993080]
[8,"levocabastine","digest","skin",null,null,19720102,10337430]
[9,"dienestrol","nervous","cardiac",null,null,1153373]
[9,"aminoglutethimide","nervous","cardiac",null,null,3091560,2791999]
[9,"miglustat","nervous","cardiac",null,null,18221193,23146215]
[9,"sparfloxacin","nervous","cardiac",null,null,1337351,11040352]
[9,"chenodeoxycholic acid","nervous","cardiac",null,null,12486565,8682154]
[9,"calcipotriol","nervous","cardiac",null,null,8741415,9888112]
[9,"methylergonovine","nervous","cardiac",null,null,2316452]
[9,"cefazolin","nervous","cardiac",null,null,3373292,20570290]
[9,"rocuronium","nervous","cardiac",null,null,12707123,23136807]
[9,"metyrapone","nervous","cardiac",null,null,4321814,11856816]
[9,"amsacrine","nervous","cardiac",null,null,2372760,2372760]
[9,"dicyclomine","nervous","cardiac",null,null,18455881,2432979]
[9,"isopropamide","nervous","cardiac",null,null,14085979,3580704]
[9,"diphenylpyraline","nervous","cardiac",null,null,7920432,8735]
[9,"cyclizine","nervous","cardiac",null,null,6120718,15207762]
[11,"glycine","cardiac","nervous",null,null,22971924,23353105]
[11,"ipratropium bromide","cardiac","nervous",null,null,18488440,22906782]
[11,"chlormezanone","cardiac","nervous",null,null,8527020,"http://clinicaltrials.gov/ct2/show/NCT01450865?term=chlormezanone+and+nervous&rank=1",null,null,null,"tspo"]
[11,"l-glutamic acid","cardiac","nervous",null,null,8975838,23530508]
[11,"ritodrine","cardiac","nervous",null,null,12132249,1343015]
[11,"trimethoprim","cardiac","nervous",null,null,15927910,23707647]
[11,"nelarabine","cardiac","nervous",null,null,17344466]
[11,"proparacaine","cardiac","nervous",null,null,"http://clinicaltrials.gov/ct2/show/NCT00501826?term=nelarabine+and+nervous&rank=1","http://clinicaltrials.gov/ct2/show/NCT00748059?term=proparacaine+and+nervous&rank=1"]
[11,"cinacalcet","cardiac","nervous",null,null,17257349,"http://clinicaltrials.gov/ct2/show/NCT01103206?term=cinacalcet+and+nervous&rank=1",null,null,null,"casr"]
[11,"atovaquone","cardiac","nervous",null,null,20722247,10649835]
[11,"baclofen","cardiac","nervous",null,null,21725173,22266766]
[11,"danazol","cardiac","nervous",null,null,22239184,2274628]
[11,"norethindrone","cardiac","nervous",null,null,21389912,15860274]
[11,"alclometasone","cardiac","nervous",null,null,null,"http://clinicaltrials.gov/ct2/show/NCT01465802?term=nervous+and+alclometasone&rank=1",null,null,"","nr3c1"]
[11,"ciprofloxacin","cardiac","nervous",null,null,22250755,19266216]
[11,"progesterone","cardiac","nervous",null,null,23049511,23280249]
[11,"desonide","cardiac","nervous",{"$nulls":7},"nr3c1"]
[11,"ciclesonide","cardiac","nervous",null,null,"http://clinicaltrials.gov/ct2/show/NCT01248065?term=ciclesonide+and+cardiac&rank=1",{"$nulls":4},"nr3c1"]
[11,"amcinonide","cardiac","nervous",{"$nulls":7},"anxa1, nr3c1"]
[11,"flutamide","cardiac","nervous",null,null,17916626,3703970]
[12,"difluprednate","urinary",null,null,null,4032501]
[13,"fluorouracil","digest","nervous",null,null,6329908,15494638]
[13,"aminolevulinic acid","digest","nervous",null,null,21439310,"http://clinicaltrials.gov/ct2/show/NCT00752323?term=aminolevulinic+acid+and+nervous&rank=1",null,null,null,"alad"]
[13,"raloxifene","digest","nervous",null,null,11164349,"http://clinicaltrials.gov/ct2/show/NCT00361543?term=raloxifene+and+nervous&rank=1",null,null,null,"esr2, esr1"]
[13,"methimazole","digest","nervous",null,null,8746812,20685232]
[13,"labetalol","digest","nervous",null,null,19491545,"http://clinicaltrials.gov/ct2/show/NCT00963976?term=labetalol+and+nervous&rank=2",null,null,null,"adra1b"]
[13,"tolterodine","digest","nervous",null,null,18326811,"http://clinicaltrials.gov/ct2/show/NCT01291316?term=tolterodine+and+nervous&rank=3",null,null,null,"chrm4, chrm3, chrm2, chrm1"]
[13,"clopidogrel","digest","nervous",null,null,19034035,"http://clinicaltrials.gov/ct2/show/NCT00249873?term=clopidogrel+and++nervous&rank=1"]
[13,"sulfinpyrazone","digest","nervous",null,null,6891177,{"$nulls":4},"abcc1, abcc2"]
[13,"acetohydroxamic acid","digest","nervous",{"$nulls":7},"mmp12"]
[13,"letrozole","digest","nervous",null,null,21369716,"http://clinicaltrials.gov/ct2/show/NCT01921296?term=letrozole+and+nervous&rank=7",null,null,null,"cyp19a1"]
[13,"flucytosine","digest","nervous",null,null,22167400,"http://clinicaltrials.gov/ct2/show/NCT02015819?term=flucytosine+and+nervous&rank=1",null,null,null,"dnmt1"]
[13,"bambuterol","digest","nervous",null,null,8223836]
[13,"epinastine","digest","nervous",null,null,9671095,{"$nulls":4},"htr2a, hrh2, adra2a"]
[13,"glucosamine","digest","nervous",null,null,8203761,17513885]
[13,"tadalafil","digest","nervous",null,null,17127429,15667388]
[13,"chlorpheniramine","digest","nervous",null,null,7876272,{"$nulls":4},"slc6a3, slc6a2, slc6a4"]
[14,"aminosalicylic acid","nervous","muscle",null,null,3547005,1647675]
[14,"l-aspartic acid","nervous","muscle",null,null,18329151,"http://clinicaltrials.gov/ct2/show/NCT01847651?term=l-aspartic+acid+and+muscle&rank=1",null,null,null,"dars, asph, asns, paics, adssl1, acy1"]
[14,"propafenone","nervous","muscle",null,null,2733262]
[14,"trospium","nervous","muscle",null,null,21607875,17637888]
[14,"pyridoxine","nervous","muscle",null,null,22466557,"http://clinicaltrials.gov/ct2/show/NCT00004734?term=pyridoxine+and+muscle&rank=1",null,null,null,"pdxp, aldh7a1"]
[14,"quinidine","nervous","muscle",null,null,16575850,22674269]
[14,"hydroxyurea","nervous","muscle",null,null,18166199,10445501]
[15,"propylthiouracil","digest","respiratory","cardiac","nervous",6353140,10488483,23150524,15649099]
[15,"pamidronate","digest","respiratory","cardiac","nervous",17931839,15207762,17931839,7654117]
[16,"phenindione","nervous","muscle","cardiac",null,4291162]
[16,"dinoprostone","nervous","muscle","cardiac",null,22364765,"http://clinicaltrials.gov/ct2/show/NCT01921374?term=dinoprostone+and+muscle&rank=1",19065371,null,null,"ptger2"]
[16,"mazindol","nervous","muscle","cardiac",null,23099177,null,15300360]
[16,"mitotane","nervous","muscle","cardiac",null,1517795,null,23013780,null,null,"cyp11b1"]
[17,"Naloxone","cardiac",null,null,null,23645463]
[17,"Ixabepilone","cardiac",null,null,null,23512664]
[18,"etoposide","nervous",null,null,null,23666221]
[19,"Perhexiline","nervous","digest",null,null,6295127]
[20,"pyridoxal","respiratory",null,null,null,21704546]
[21,"imiquimod","urinary",null,null,null,15459419]
[21,"thiethylperazine","urinary",null,null,null,1185409]
[21,"epoprostenol","urinary",null,null,null,"http://clinicaltrials.gov/ct2/show/NCT01995006?term=epoprostenol+and+urinary&rank=1"]
[21,"remifentanil","urinary",null,null,null,23741563]
[21,"amiodarone","urinary",null,null,null,22828012]
[22,"yohimbine","sensory",null,null,null,21934725]
[22,"pipecuronium","sensory",null,null,null,10653024]
[24,"enflurane","blood","nervous",null,null,17460978,"http://clinicaltrials.gov/ct2/show/NCT00990418?term=enflurane+and+nervous&rank=1"]
[25,"buclizine","nervous"]
[25,"astemizole","nervous",null,null,null,10444242]
[26,"Acebutolol","nervous","digest",null,null,2859774,{"$nulls":4},"adrb2"]
[26,"Lubiprostone","nervous","cardiac",null,null,20406855]
[28,"voglibose","nervous",null,null,null,16682681]
[28,"doxazosin","nervous",null,null,null,16216989]
[28,"gemcitabine","nervous",null,null,null,20213928]
[28,"zoledronate","nervous",null,null,null,16932956]
[29,"isoetharine","nervous","cardiac",null,null,null,3526986]
[29,"mercaptopurine","nervous","cardiac",null,null,22461033,"http://clinicaltrials.gov/ct2/show/NCT01230983?term=mercaptopurine+and+cardiac&rank=1",null,null,null,"hprt1"]
[30,"fluticasone propionate","cardiac",null,null,null,22267687]
[30,"eplerenone","respiratory","skin",null,null,null,20535129]
[32,"Diethylcarbamazine","nervous",null,null,null,18385346]
[38,"mefloquine","cardiac",null,null,null,23241425]
[40,"alendronate","cardiac",null,null,null,22693306]
[41,"repaglinide","nervous",null,null,null,11277117]
[{"$nulls":10},""]
["Literature validation for predicted indications of 42 drugs without ATC",{"$nulls":9},""]
["cluster","drugs","ATC1","ATC2","ATC3","ATC4","PMID1(ATC1)","PMID2(ATC2)","PMID3(ATC3)","PMID4(ATC4)","Target(ATC1)","Target(ATC2)","Target(ATC3)","Target(ATC4)"]
[3,"Levomethadyl Acetate","nervous","respiratory","cardiac",null,"http://clinicaltrials.gov/ct2/show/NCT00158288?term=Levomethadyl+Acetate+and+nervous&rank=1","http://clinicaltrials.gov/ct2/show/NCT00000356?term=Levomethadyl+Acetate+and+respiratory&rank=1","http://clinicaltrials.gov/ct2/show/NCT00999440?term=Levomethadyl+Acetate+and+cardiac&rank=1",null,"chrnb4, chrna3"]
[3,"Clotiazepam","nervous","respiratory","cardiac",null,6144806,{"$nulls":4},"gabrr1","gabra1"]
[3,"Ridogrel","nervous","respiratory","cardiac",{"$nulls":5},"tbxas1","tbxas1"]
[3,"Cilastatin","nervous","respiratory","cardiac",null,1926900,21661712,9059911,null,""]
[4,"L-Asparagine","nervous","cardiac",null,null,22643319,"http://clinicaltrials.gov/ct2/show/NCT01425983?term=L-Asparagine+and+cardiac&rank=1",null,null,null,"slc38a3"]
[4,"L-Proline","nervous","cardiac",null,null,7651355,225056]
[4,"L-Valine","nervous","cardiac",null,null,2232866,2123803]
[4,"Succinic acid","nervous","cardiac",null,null,18393771,9316202]
[4,"Tetrahydrofolic acid","nervous","cardiac",{"$nulls":6},"atic, mthfd2, mthfd1, mtr, aldh1l1, mthfr, shmt2","mthfd2"]
[4,"Anisindione","nervous","cardiac",{"$nulls":6},""]
[5,"Methadyl Acetate","nervous","cardiac",null,null,"http://clinicaltrials.gov/ct2/show/NCT00158288?term=Methadyl+Acetate+and+nervous&rank=2","http://clinicaltrials.gov/ct2/show/NCT00999440?term=Methadyl+Acetate+and+cardiac&rank=1",null,null,""]
[5,"Indecainide","nervous","cardiac",null,null,3296725,3296725]
[5,"Levallorphan","nervous","cardiac",null,null,6086363,8377218]
[6,"Cerulenin","nervous",null,null,null,15044358]
[7,"Lisdexamfetamine","nervous","digest",null,null,20057893,"http://clinicaltrials.gov/ct2/show/NCT00573534?term=Lisdexamfetamine+and+digest&rank=1"]
[7,"Diphemanil ","nervous","digest",{"$nulls":6},""]
[7,"Clidinium","nervous","digest",null,null,"http://clinicaltrials.gov/ct2/show/NCT00516854?term=Clidinium+and+nervous&rank=1",null,null,null,"chrm1"]
[9,"Butethal","nervous","cardiac",null,null,15514906,{"$nulls":4},"gabra4, gabra1"]
[9,"Thiamylal","nervous","cardiac",null,null,6829912,23157103]
[9,"Butabarbital","nervous","cardiac",null,null,1185595,{"$nulls":4},"gabra4, gabra1"]
[8,"Dromostanolone","digest","skin",{"$nulls":6},"","ar"]
[10,"Oxymorphone","nervous","respiratory",null,null,18360598,2451454]
[11,"Adenine","nervous","cardiac",null,null,23147562,23242185]
[11,"Tamibarotene","nervous","cardiac",null,null,22863914]
[11,"Cortisone acetate","nervous","cardiac",null,null,3006447,6236191]
[12,"Estropipate","urinary",null,null,null,"http://clinicaltrials.gov/ct2/show/NCT01089049?term=Estropipate+and+urinary&rank=1",null,null,null,"esr1"]
[12,"Drospirenone","urinary",null,null,null,15625142]
[13,"L-Isoleucine","nervous","digest",null,null,1453492,{"$nulls":4},"iars, acadsb"]
[13,"Methacholine","nervous","digest",null,null,21167892,11325793]
[13,"L-Leucine","nervous","digest",null,null,1453492,6114473]
[13,"Aspartame","nervous","digest",null,null,17684524,22202183]
[13,"Cycrimine","nervous","digest",{"$nulls":6},"chrm1"]
[15,"L-Histidine","digest","respiratory","cardiac","nervous",7235692,23441838,1474497,17196744]
[15,"L-Phenylalanine","digest","respiratory","cardiac","nervous",6807099,10540175,15878997,1998514]
[15,"L-Tyrosine","digest","respiratory","cardiac","nervous",19871468,15740734,1699105,20007094]
[16,"Phendimetrazine","nervous","muscle","cardiac",null,16265126,null,9799071,null,null,"adra1b"]
[16,"Fospropofol","nervous","muscle","cardiac",null,22529044,null,22529044,null,null,"gabrb2"]
[18,"L-Cystine","nervous",null,null,null,15516806]
[18,"Quinacrine","nervous",null,null,null,14751779]
[20,"Enprofylline","respiratory",null,null,null,3425350]
[21,"Spermine","urinary",null,null,null,19812367]
[25,"Carphenazine","nervous",null,null,null,5338760]