{"text_format":"2","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":77,"n_cols":6,"rows_kept":77,"cut":false,"hidden":false,"merged":[[0,0,0,4]],"flags":["formulas_cached_only"]}
["Table S8. Enriched GO terms and KEGG pathways in targets of differentially expressed miRNAs in gallstone"]
["GOID","Ontology Source","GOTerm","Nr. Genes","Term PValue Corrected with Benjamini-Hochberg","Associated Genes Found"]
["GO:0038028","GO_BiologicalProcess_16.11.2010_17h17","insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade",3,3.1e-05,"NM_001127598, NM_000612, NM_001007139"]
["GO:0045969","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of hormone biosynthetic process",3,3.1e-05,"NM_001127598, NM_000612, NM_001007139"]
["GO:0090031","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of steroid hormone biosynthetic process",3,3.1e-05,"NM_001127598, NM_000612, NM_001007139"]
["GO:0010893","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of steroid biosynthetic process",3,0.0003,"NM_001127598, NM_000612, NM_001007139"]
["GO:0090030","GO_BiologicalProcess_16.11.2010_17h17","regulation of steroid hormone biosynthetic process",3,0.0003,"NM_001127598, NM_000612, NM_001007139"]
["GO:0046885","GO_BiologicalProcess_16.11.2010_17h17","regulation of hormone biosynthetic process",3,0.00061,"NM_001127598, NM_000612, NM_001007139"]
["GO:2000467","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of glycogen (starch) synthase activity",3,0.00061,"NM_001127598, NM_000612, NM_001007139"]
["GO:0032352","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of hormone metabolic process",3,0.00255,"NM_001127598, NM_000612, NM_001007139"]
["GO:2000465","GO_BiologicalProcess_16.11.2010_17h17","regulation of glycogen (starch) synthase activity",3,0.00255,"NM_001127598, NM_000612, NM_001007139"]
["GO:0031017","GO_BiologicalProcess_16.11.2010_17h17","exocrine pancreas development",3,0.00861,"NM_001127598, NM_000612, NM_001007139"]
["GO:0060539","GO_BiologicalProcess_16.11.2010_17h17","diaphragm development",3,0.00861,"NM_001004356, NM_021923, NM_001004358"]
["GO:0032350","GO_BiologicalProcess_16.11.2010_17h17","regulation of hormone metabolic process",3,0.01092,"NM_001127598, NM_000612, NM_001007139"]
["GO:0045725","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of glycogen biosynthetic process",3,0.01092,"NM_001127598, NM_000612, NM_001007139"]
["GO:0045940","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of steroid metabolic process",3,0.01092,"NM_001127598, NM_000612, NM_001007139"]
["GO:0003170","GO_BiologicalProcess_16.11.2010_17h17","heart valve development",3,0.01671,"NM_001004356, NM_021923, NM_001004358"]
["GO:0003179","GO_BiologicalProcess_16.11.2010_17h17","heart valve morphogenesis",3,0.01671,"NM_001004356, NM_021923, NM_001004358"]
["GO:0001503","GO_BiologicalProcess_16.11.2010_17h17","ossification",6,0.01962,"NM_001127598, NM_000612, NM_000540, NM_001007139,NM_000112, NM_001042723"]
["GO:0070875","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of glycogen metabolic process",3,0.02023,"NM_001127598, NM_000612, NM_001007139"]
["GO:2000273","GO_BiologicalProcess_16.11.2010_17h17","positive regulation of receptor activity",3,0.02421,"NM_001127598, NM_000612, NM_001007139"]
["GO:0061061","GO_BiologicalProcess_16.11.2010_17h17","muscle structure development",9,0.02984,"NM_001004356, NM_001127598, NM_000540, NM_001007139,NM_001004358, NM_006885, NM_000612, NM_021923,NM_001042723"]
["GO:0043279","GO_BiologicalProcess_16.11.2010_17h17","response to alkaloid",5,0.03174,"NM_001127598, NM_000612, NM_000540, NM_001007139,NM_001042723"]
["GO:0050810","GO_BiologicalProcess_16.11.2010_17h17","regulation of steroid biosynthetic process",3,0.03911,"NM_001127598, NM_000612, NM_001007139"]
["GO:0014808","GO_BiologicalProcess_16.11.2010_17h17","release of sequestered calcium ion into cytosol by sarcoplasmic reticulum",2,0.04669,"NM_000540, NM_001042723"]
["GO:0051581","GO_BiologicalProcess_16.11.2010_17h17","negative regulation of neurotransmitter uptake",2,0.04669,"NM_001204213, NM_000620"]
["GO:0051611","GO_BiologicalProcess_16.11.2010_17h17","regulation of serotonin uptake",2,0.04669,"NM_001204213, NM_000620"]
["GO:0051612","GO_BiologicalProcess_16.11.2010_17h17","negative regulation of serotonin uptak",2,0.04669,"NM_001204213, NM_000620"]
["GOID","Ontology Source","GOTerm","Nr. Genes","Term PValue Corrected with Benjamini-Hochberg","Associated Genes Found"]
["GO:0005007","GO_MolecularFunction_16.11.2010_17h17","fibroblast growth factor-activated receptor activity",3,0.00017,"NM_001004356, NM_021923, NM_001004358"]
["GO:0043539","GO_MolecularFunction_16.11.2010_17h17","protein serine/threonine kinase activator activity",3,0.00017,"NM_001127598, NM_000612, NM_001007139"]
["GO:0004222","GO_MolecularFunction_16.11.2010_17h17","metalloendopeptidase activity",7,0.00052,"NM_001278127, NM_001278126, NM_001130703, NM_001130705,NM_014269, NM_001278125, NM_001130704"]
["GO:0005159","GO_MolecularFunction_16.11.2010_17h17","insulin-like growth factor receptor binding",3,0.00239,"NM_001127598, NM_000612, NM_001007139"]
["GO:0008237","GO_MolecularFunction_16.11.2010_17h17","metallopeptidase activity",7,0.0118,"NM_001278127, NM_001278126, NM_001130703, NM_001130705,NM_014269, NM_001278125, NM_001130704"]
["GO:0017134","GO_MolecularFunction_16.11.2010_17h17","fibroblast growth factor binding",3,0.01257,"NM_001004356, NM_021923, NM_001004358"]
["GO:0034185","GO_MolecularFunction_16.11.2010_17h17","apolipoprotein binding",2,0.01299,"NM_002332, NM_005577"]
["GO:0005219","GO_MolecularFunction_16.11.2010_17h17","ryanodine-sensitive calcium-release channel activity",2,0.0216,"NM_000540, NM_001042723"]
["GO:0005218","GO_MolecularFunction_16.11.2010_17h17","intracellular ligand-gated calcium channel activity",2,0.03232,"NM_000540, NM_001042723"]
["GO:0030295","GO_MolecularFunction_16.11.2010_17h17","protein kinase activator activity",3,0.03237,"NM_001127598, NM_000612, NM_001007139"]
["GO:0030295","GO_MolecularFunction_16.11.2010_17h17","kinase activator activity",3,0.03931,"NM_001127598, NM_000612, NM_001007139"]
["PathwayID","KEGGID","GOTerm","Nr. Genes","Term PValue","Associated Genes Found"]
["map05410","K12567","Hypertrophic cardiomyopathy (HCM)",6,1.162941e-05,"NM_003319;NM_133378;NM_133432;NM_133437;NM_001256850;NM_001267550"]
["map05414","K12567","Dilated cardiomyopathy",6,2.031885e-05,"NM_003319;NM_133378;NM_133432;NM_133437;NM_001256850;NM_001267550"]
["map05144","K04550;K04011","Malaria",3,0.001385846,"NM_002332;NM_000573;NM_000651"]
["map05205","K02329;K13769","Proteoglycans in cancer",6,0.002590298,"NM_017412;NM_145866;NM_001127598;NM_001007139;NM_000612;NR_003512"]
["map05217","K02329;K02085","Basal cell carcinoma",3,0.002927037,"NM_017412;NM_145866;NM_001127511"]
["map04730","K13240;K04961","Long-term depression",3,0.0057939,"NM_000620;NM_000540;NM_001042723"]
["map00310","K09188;K09187","Lysine degradation",2,0.02970555,"NM_170606;NM_003482"]
["map04713","K13240;K04961","Circadian entrainment",3,0.03723893,"NM_000620;NM_000540;NM_001042723"]
["map05134","K04011","Legionellosis",2,0.03813524,"NM_000573;NM_000651"]
["map00330","K13240;K13253","Arginine and proline metabolism",2,0.04342485,"NM_000620;NM_001204213"]
["map04310","K02329;K02085","Wnt signaling pathway",3,0.0479137,"NM_017412;NM_145866;NM_001127511"]
["map05140","K04011","Leishmaniasis",2,0.04816331,"NM_000573;NM_000651"]
["map04610","K04011","Complement and coagulation cascades",2,0.05060037,"NM_000573;NM_000651"]
["map04390","K02329;K02085","Hippo signaling pathway",3,0.05783688,"NM_017412;NM_145866;NM_001127511"]
["map04640","K04011","Hematopoietic cell lineage",2,0.07066228,"NM_000573;NM_000651"]
["map04970","K13240;K13908","Salivary secretion",2,0.07626213,"NM_000620;NM_002458"]
["map04916","K02329","Melanogenesis",2,0.1020158,"NM_017412;NM_145866"]
["map04020","K13240;K04961","Calcium signaling pathway",3,0.1301141,"NM_000620;NM_000540;NM_001042723"]
["map05200","K02329;K02085;K08803","Pathways in cancer",4,0.1326129,"NM_017412;NM_145866;NM_001127511;NM_004938"]
["map05166","K02329;K02085","HTLV-I infection",3,0.1923257,"NM_017412;NM_145866;NM_001127511"]
["map02010","K05652","ABC transporters",1,0.1951733,"NM_080282"]
["map05219","K08803","Bladder cancer",1,0.2161188,"NM_004938"]
["map05010","K13240;K04550","Alzheimer's disease",2,0.2569371,"NM_000620;NM_002332"]
["map05110","K10955","Vibrio cholerae infection",1,0.2661642,"NM_002457"]
["map05152","K04011","Tuberculosis",2,0.2703324,"NM_000573;NM_000651"]
["map05014","K13240","Amyotrophic lateral sclerosis (ALS)",1,0.2805549,"NM_000620"]
["map05213","K02085","Endometrial cancer",1,0.2876458,"NM_001127511"]
["map03008","K14550","Ribosome biogenesis in eukaryotes",1,0.326547,"NM_018072"]
["map05210","K02085","Colorectal cancer",1,0.3309839,"NM_001127511"]
["map05146","K10955","Amoebiasis",1,0.4441794,"NM_002457"]
["map04725","K14387","Cholinergic synapse",1,0.5445729,"NM_021815"]
["map04145","K13240","Phagosome",1,0.5594725,"NM_000620"]
["map04120","K10594","Ubiquitin mediated proteolysis",1,0.6079404,"NM_003922"]
["map04810","K02085","Regulation of actin cytoskeleton",1,0.7258341,"NM_001127511"]
["map01110","K13253","Biosynthesis of secondary metabolites",1,0.8229525,"NM_001204213"]
["map01100","K13240;K13253","Metabolic pathways",2,0.990319,"NM_000620;NM_001204213"]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}