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["Estellon et al., List of supplementary table:"]
["Supplementary Table 1: FeS proteins experimentally characterized in Escherichia coli"]
["Supplementary Table 2: Public Fe-S descriptors used in the predictive models"]
["Supplementary Table 3: List of FeS proteins extracted from the PDB70 (training set)"]
["Supplementary Table 4: Fe-S proteins in E.coli predicted by the mixed model"]
["Supplementary Table 5: Weights of the linear model trained on the PDB70 Dataset (mixed model) "]
["Supplementary Table 6: Fe-S proteins in E.coli predicted by the extended model"]
["Supplementary Table 7: Annotation of candidate E. Coli Fe-S proteins"]
["Supplementary Table 8: Comparison predictions provided by the extended model (InFeS) and InterPro"]
["Supplementary Table 9: List of  microbial organisms studied with the highest Fe-S protein content"]

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["Entry","Entry name (UniProtKB)","Functional class","Reference","Alternative names","Interpro Hits","Gene names","Protein names","Length","Gene ontology (GO)","General annotation (cofactor)","Cross-reference (PDB)"]
["P25516","ACON1_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"4Fe-4S cluster binding site (IPR018136)","acnA acn b1276 JW1268","Aconitate hydratase 1 (Aconitase 1) (EC 4.2.1.3) (Citrate hydro-lyase 1)",891,"4 iron, 4 sulfur cluster binding; aconitate hydratase activity; anaerobic respiration; citrate hydro-lyase (cis-aconitate-forming) activity; cytoplasm; glyoxylate cycle; iron ion binding; isocitrate hydro-lyase (cis-aconitate-forming) activity; mRNA 3'-UTR binding; response to oxidative stress; tricarboxylic acid cycle"," Binds 1 4Fe-4S cluster per subunit (By similarity)."]
["P36683","ACON2_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"4Fe-4S cluster binding site (IPR018136)","acnB yacI yacJ b0118 JW0114","Aconitate hydratase 2 (Aconitase) (EC 4.2.1.3) (2-methylisocitrate dehydratase) (EC 4.2.1.99) (Citrate hydro-lyase)",865,"2-methylisocitrate dehydratase activity; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; citrate hydro-lyase (cis-aconitate-forming) activity; cytosol; glyoxylate cycle; isocitrate hydro-lyase (cis-aconitate-forming) activity; mRNA 3'-UTR binding; metal ion binding; propionate catabolic process, 2-methylcitrate cycle; regulation of translation; tricarboxylic acid cycle"," Binds 1 4Fe-4S cluster per subunit.","1L5J;"]
["P25550","ASLB_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008","ATSB","4Fe4S-binding SPASM domain (IPR023885)","aslB atsB b3800 JW5594","Anaerobic sulfatase-maturating enzyme homolog AslB (AnSME homolog)",411,"4 iron, 4 sulfur cluster binding; metal ion binding; oxidation-reduction process; oxidoreductase activity; protein maturation"," Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).;  May bind at least one other iron-sulfur cluster (Potential)."]
["P0AE56","BFD_ECOLI","Electron transfert","Fontecave et al, 2008",null,"BFD-like [2Fe-2S]-binding domain (IPR007419)","bfd yheA b3337 JW3299","Bacterioferritin-associated ferredoxin",64,"2 iron, 2 sulfur cluster binding; electron transport chain; metal ion binding"," Binds 1 2Fe-2S cluster."]
["P12996","BIOB_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","bioB b0775 JW0758","Biotin synthase (EC 2.8.1.6)",346,"2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; biotin biosynthetic process; biotin synthase activity; iron ion binding"," Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;  Binds 1 2Fe-2S cluster. The cluster is coordinated with 3 cysteines and 1 arginine.","1R30;"]
["P17846","CYSI_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Nitrite/sulphite reductase 4Fe-4S domain (IPR006067)","cysI b2763 JW2733","Sulfite reductase [NADPH] hemoprotein beta-component (SiR-HP) (SiRHP) (EC 1.8.1.2)",570,"4 iron, 4 sulfur cluster binding; NADP binding; cysteine biosynthetic process; heme binding; hydrogen sulfide biosynthetic process; metal ion binding; sulfate assimilation; sulfite reductase (NADPH) activity; sulfite reductase complex (NADPH)"," Binds 1 siroheme per subunit.;  Binds 1 4Fe-4S cluster per subunit.","1AOP;2AOP;2GEP;3AOP;3GEO;4AOP;4G38;4G39;4GEP;4HTR;5AOP;5GEP;6GEP;7GEP;8GEP;"]
["P07014","DHSB_ECOLI","Electron transfert","Fontecave et al, 2008","SDHB","2Fe-2S ferredoxin-type domain (IPR001041); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","sdhB b0724 JW0714","Succinate dehydrogenase iron-sulfur subunit (EC 1.3.99.1)",238,"2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aerobic respiration; electron carrier activity; electron transport chain; metal ion binding; plasma membrane; succinate dehydrogenase activity; tricarboxylic acid cycle"," Binds 1 2Fe-2S cluster.;  Binds 1 3Fe-4S cluster.;  Binds 1 4Fe-4S cluster.","1NEK;1NEN;2ACZ;2AD0;2WDQ;2WDR;2WDV;2WP9;2WS3;2WU2;2WU5;"]
["P18775","DMSA_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","dmsA b0894 JW5118","Dimethyl sulfoxide reductase DmsA (DMSO reductase) (DMSOR) (Me2SO reductase) (EC 1.8.5.3)",814,"4 iron, 4 sulfur cluster binding; anaerobic respiration; dimethyl sulfoxide reductase activity; dimethyl sulfoxide reductase complex; electron carrier activity; iron ion binding; membrane; molybdenum ion binding; oxidoreductase activity; plasma membrane"," Binds 1 4Fe-4S cluster (Potential).;  Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit."]
["P18776","DMSB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","dmsB b0895 JW0878","Anaerobic dimethyl sulfoxide reductase chain B (DMSO reductase iron-sulfur subunit)",205,"4 iron, 4 sulfur cluster binding; anaerobic respiration; dimethyl sulfoxide reductase complex; electron carrier activity; electron transport chain; iron ion binding"," Binds 4 4Fe-4S clusters."]
["P0AB83","END3_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008","NTH","Endonuclease III, iron-sulphur binding site (IPR004035)","nth b1633 JW1625","Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase)",211,"4 iron, 4 sulfur cluster binding; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; base-excision repair; endonuclease activity; hydrolase activity, acting on glycosyl bonds; metal ion binding"," Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in DNA-binding and proper positioning of the enzyme along the DNA strand.","2ABK;"]
["P0ACC3","ERPA_ECOLI","Metallosite assembly","Fontecave et al, 2008",null,"No iron-sulfur binding hit","erpA yadR b0156 JW0152","Iron-sulfur cluster insertion protein ErpA",114,"2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aerobic respiration; anaerobic respiration; iron ion binding; iron-sulfur cluster assembly; protein maturation; structural molecule activity"," Binds 1 iron-sulfur cluster per subunit. A study found 40-50% as 2Fe-2S clusters, 15-25% as 4Fe-4S clusters and the rest as paramagnetic iron."]
["P42593","FADH_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","fadH ygjL b3081 JW3052","2,4-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34) (2,4-dienoyl coenzyme A reductase)",672,"2,4-dienoyl-CoA reductase (NADPH) activity; 4 iron, 4 sulfur cluster binding; FMN binding; metal ion binding"," FAD.","1PS9;"]
["P32177","FDHD_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","fdhD b3895 JW3866","Protein FdhD",277,"anaerobic respiration; cytoplasm; formate dehydrogenase (NAD+) activity; formate dehydrogenase complex"]
["P07658","FDHF_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","fdhF b4079 JW4040","Formate dehydrogenase H (EC 1.1.99.33) (EC 1.2.1.2) (Formate dehydrogenase-H subunit alpha) (FDH-H) (Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide)",715,"4 iron, 4 sulfur cluster binding; cytosol; electron carrier activity; formate dehydrogenase (NAD+) activity; formate oxidation; membrane; molybdenum ion binding; oxidoreductase activity"," Binds 1 4Fe-4S cluster per subunit.;  Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","1AA6;1FDI;1FDO;2IV2;"]
["P24183","FDNG_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","fdnG b1474 JW1470","Formate dehydrogenase, nitrate-inducible, major subunit (EC 1.2.1.2) (Anaerobic formate dehydrogenase major subunit) (Formate dehydrogenase-N subunit alpha) (FDH-N subunit alpha)",1015,"4 iron, 4 sulfur cluster binding; anaerobic respiration; cytoplasm; electron carrier activity; formate dehydrogenase (NAD+) activity; formate dehydrogenase complex; membrane; molybdenum ion binding; periplasmic space"," Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.;  Binds 1 4Fe-4S cluster per subunit.","1KQF;1KQG;"]
["P0AAJ3","FDNH_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","fdnH b1475 JW1471","Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (Anaerobic formate dehydrogenase iron-sulfur subunit) (Formate dehydrogenase-N subunit beta) (FDH-N subunit beta)",294,"4 iron, 4 sulfur cluster binding; anaerobic respiration; electron carrier activity; electron transport chain; formate dehydrogenase (NAD+) activity; formate dehydrogenase complex; integral to membrane; membrane; metal ion binding; plasma membrane"," Binds 4 4Fe-4S clusters per subunit.","1KQF;1KQG;"]
["P32176","FDOG_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","fdoG b3894 JW3865","Formate dehydrogenase-O major subunit (EC 1.2.1.2) (Aerobic formate dehydrogenase major subunit) (FDH-Z subunit alpha) (Formate dehydrogenase-O subunit alpha)",1016,"4 iron, 4 sulfur cluster binding; anaerobic respiration; cytoplasm; electron carrier activity; formate dehydrogenase (NAD+) activity; membrane; molybdenum ion binding; molybdopterin cofactor binding; oxidoreductase activity; periplasmic space; response to DNA damage stimulus"," Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).;  Binds 1 4Fe-4S cluster (Potential)."]
["P0AAJ5","FDOH_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","fdoH b3893 JW3864","Formate dehydrogenase-O iron-sulfur subunit (Aerobic formate dehydrogenase iron-sulfur subunit) (FDH-Z subunit beta) (Formate dehydrogenase-O subunit beta)",300,"4 iron, 4 sulfur cluster binding; anaerobic respiration; electron carrier activity; electron transport chain; formate dehydrogenase (NAD+) activity; integral to membrane; membrane; metal ion binding; plasma membrane"," Binds 4 4Fe-4S clusters per subunit (By similarity)."]
["P0A9R4","FER_ECOLI","Electron transfert","Fontecave et al, 2008","FDX","2Fe-2S ferredoxin-type domain (IPR001041); Ferredoxin, 2Fe-2S type (IPR011536); Adrenodoxin, iron-sulphur binding site (IPR018298)","fdx b2525 JW2509","2Fe-2S ferredoxin",111,"2 iron, 2 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding"," Binds 1 2Fe-2S cluster.","1I7H;"]
["P39405","FHUF_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","fhuF yjjS b4367 JW4331","Ferric iron reductase protein FhuF",262,"2 iron, 2 sulfur cluster binding; cytoplasm; iron assimilation; metal ion binding; plasma membrane"," Binds 1 2Fe-2S cluster."]
["P0A9E5","FNR_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008",null,"No iron-sulfur binding hit","fnr nirR b1334 JW1328","Fumarate and nitrate reduction regulatory protein",250,"4 iron, 4 sulfur cluster binding; DNA binding; anaerobic respiration; cytoplasm; metal ion binding; response to nitric oxide; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent"," Binds 1 4Fe-4S cluster per subunit."]
["P0AC47","FRDB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"2Fe-2S ferredoxin-type domain (IPR001041); 2Fe-2S ferredoxin, iron-sulphur binding site (IPR006058); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","frdB b4153 JW4114","Fumarate reductase iron-sulfur subunit (EC 1.3.99.1)",244,"2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; anaerobic respiration; ciliary or bacterial-type flagellar motility; cytoplasm; electron carrier activity; electron transport chain; fermentation; membrane; metal ion binding; succinate dehydrogenase activity; tricarboxylic acid cycle"," Binds 1 2Fe-2S cluster.;  Binds 1 3Fe-4S cluster.;  Binds 1 4Fe-4S cluster.","1KF6;1KFY;1L0V;2B76;3CIR;3P4P;3P4Q;3P4R;3P4S;"]
["P0AC33","FUMA_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain (IPR004646); Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain (IPR004647)","fumA b1612 JW1604","Fumarate hydratase class I, aerobic (Fumarase) (EC 4.2.1.2)",548,"4 iron, 4 sulfur cluster binding; cytosol; fumarate hydratase activity; metal ion binding; oxaloacetate tautomerase activity; tricarboxylic acid cycle"," Binds 1 4Fe-4S cluster."]
["P14407","FUMB_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain (IPR004646); Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain (IPR004647)","fumB b4122 JW4083","Fumarate hydratase class I, anaerobic (Fumarase) (EC 4.2.1.2)",548,"4 iron, 4 sulfur cluster binding; D(-)-tartrate dehydratase activity; biofilm formation; cytosol; fumarate hydratase activity; metal ion binding; response to DNA damage stimulus; tricarboxylic acid cycle"," Binds 1 4Fe-4S cluster."]
["P13033","GLPB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","glpB b2242 JW2236","Anaerobic glycerol-3-phosphate dehydrogenase subunit B (Anaerobic G-3-P dehydrogenase subunit B) (Anaerobic G3Pdhase B) (EC 1.1.5.3)",419,"glycerol catabolic process; plasma membrane; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"," FMN."]
["P09831","GLTB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","gltB aspB b3212 JW3179","Glutamate synthase [NADPH] large chain (EC 1.4.1.13) (Glutamate synthase subunit alpha) (GLTS alpha chain) (NADPH-GOGAT)",1486,"3 iron, 4 sulfur cluster binding; L-glutamate biosynthetic process; glutamate biosynthetic process; glutamate synthase (NADPH) activity; glutamine metabolic process; metal ion binding"," Binds 1 3Fe-4S cluster.;  FAD.;  FMN."]
["P09832","GLTD_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896)","gltD aspB b3213 JW3180","Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (NADPH-GOGAT)",472,"4 iron, 4 sulfur cluster binding; L-glutamate biosynthetic process; flavin adenine dinucleotide binding; glutamate biosynthetic process; glutamate synthase (NADPH) activity; metal ion binding"," Binds 1 4Fe-4S cluster."]
["P0ABW0","HCAC_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Rieske [2Fe-2S] iron-sulphur domain (IPR017941)","hcaC hcaA3 phdB yfhW b2540 JW2524","3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit (Digoxigenin ferredoxin subunit)",106,"2 iron, 2 sulfur cluster binding; 3-phenylpropionate catabolic process; 3-phenylpropionate dioxygenase activity; electron transport chain; metal ion binding"]
["P75825","HCP_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","hcp ybjW b0873 JW0857","Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP)",550,"2 iron, 2 sulfur cluster binding; cytoplasm; hydroxylamine reductase activity; metal ion binding; nitrogen compound metabolic process; peroxidase activity; response to hydrogen peroxide"," Binds 1 2Fe-2S cluster.;  Binds 1 hybrid 4Fe-2O-2S cluster."]
["P75824","HCR_ECOLI","Electron transfert","Fontecave et al, 2008",null,"2Fe-2S ferredoxin-type domain (IPR001041)","hcr ybjV b0872 JW5117","NADH oxidoreductase hcr (EC 1.-.-.-)",322,"2 iron, 2 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; oxidoreductase activity"," Binds 1 2Fe-2S cluster.;  FAD."]
["P32131","HEMN_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","hemN yihJ b3867 JW3838","Oxygen-independent coproporphyrinogen-III oxidase (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.99.22)",457,"4 iron, 4 sulfur cluster binding; coproporphyrinogen dehydrogenase activity; coproporphyrinogen oxidase activity; cytoplasm; metal ion binding; protoporphyrinogen IX biosynthetic process from glutamate"," Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","1OLT;"]
["P0AAJ8","HYBA_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","hybA b2996 JW2964","Hydrogenase-2 operon protein HybA",328,"4 iron, 4 sulfur cluster binding; electron carrier activity; metal ion binding; oxidoreductase activity; periplasmic space"," Binds 4 4Fe-4S clusters (By similarity)."]
["P0AAK1","HYCB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","hycB hevB b2724 JW2694","Formate hydrogenlyase subunit 2 (FHL subunit 2) (Hydrogenase-3 component B)",203,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding"," Binds 4 4Fe-4S clusters (By similarity)."]
["P16432","HYCF_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","hycF hevF b2720 JW2690","Formate hydrogenlyase subunit 6 (FHL subunit 6) (Hydrogenase-3 component F)",180,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding"]
["P16433","HYCG_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","hycG hevG b2719 JW2689","Formate hydrogenlyase subunit 7 (FHL subunit 7) (Hydrogenase-3 component G)",255,"4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; quinone binding"," Binds 1 4Fe-4S cluster (Potential)."]
["P23481","HYFA_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","hyfA yffE b2481 JW2466","Hydrogenase-4 component A (EC 1.-.-.-)",205,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; oxidoreductase activity"," Binds 4 4Fe-4S clusters (By similarity)."]
["P77423","HYFH_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","hyfH b2488 JW2473","Hydrogenase-4 component H",181,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding"]
["P77668","HYFI_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","hyfI b2489 JW5805","Hydrogenase-4 component I (EC 1.-.-.-)",252,"4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; quinone binding"," Binds 1 4Fe-4S cluster (Potential)."]
["P71229","HYFR_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","hyfR b2491 JW2476","Hydrogenase-4 transcriptional activator",670,"ATP binding; DNA binding; DNA-dependent transcription, initiation; nucleoside-triphosphatase activity; phosphorelay signal transduction system; regulation of DNA-dependent transcription, initiation; sequence-specific DNA binding transcription factor activity"]
["P05791","ILVD_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"No iron-sulfur binding hit","ilvD b3771 JW5605","Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9)",616,"4 iron, 4 sulfur cluster binding; dihydroxy-acid dehydratase activity; isoleucine biosynthetic process; metal ion binding; valine biosynthetic process"," Binds 1 4Fe-4S cluster."]
["P0AAC8","ISCA_ECOLI","Metallosite assembly","Fontecave et al, 2008",null,"No iron-sulfur binding hit","iscA yfhF b2528 JW2512","Iron-binding protein IscA (Iron-sulfur cluster assembly protein)",107,"2 iron, 2 sulfur cluster binding; ferrous iron binding; iron chaperone activity; iron-sulfur cluster assembly; structural molecule activity"," Binds 2 iron ions per dimer. The dimer may bind additional iron ions.","1R94;1R95;1S98;"]
["P0AGK8","ISCR_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008",null,"No iron-sulfur binding hit","iscR yfhP b2531 JW2515","HTH-type transcriptional regulator IscR",162,"2 iron, 2 sulfur cluster binding; double-stranded DNA binding; iron ion binding; response to stress; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent"," Binds 1 2Fe-2S cluster; whether or not the Fe-S cluster is necessary for transcriptional regulation depends on the type of IscR-binding sequence (PubMed:16677314).","4HF0;4HF1;4HF2;"]
["P62620","ISPG_ECOLI","Redox Catalysis","Fontecave et al, 2008",null,"No iron-sulfur binding hit","ispG gcpE b2515 JW2499","4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein GcpE) (Protein E)",372,"4 iron, 4 sulfur cluster binding; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; iron ion binding; isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; terpenoid biosynthetic process; ubiquinone biosynthetic process"," Binds 1 4Fe-4S cluster."]
["P62623","ISPH_ECOLI","Redox Catalysis","Fontecave et al, 2008",null,"No iron-sulfur binding hit","ispH lytB yaaE b0029 JW0027","4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2)",316,"3 iron, 4 sulfur cluster binding; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; dimethylallyl diphosphate biosynthetic process; hydroxymethylbutenyl pyrophosphate reductase activity; isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; metal ion binding; response to antibiotic; terpenoid biosynthetic process; ubiquinone biosynthetic process"," Binds 1 3Fe-4S cluster per subunit.","3F7T;3KE8;3KE9;3KEF;3KEL;3KEM;3SZL;3SZO;3SZU;3T0F;3T0G;3URK;3UTC;3UTD;3UV3;3UV6;3UV7;3UWM;3ZGL;3ZGN;4EB3;4H4C;4H4D;4H4E;"]
["P0A6A6","LEUC_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"Aconitase family, 4Fe-4S cluster binding site (IPR018136)","leuC b0072 JW0071","3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)",466,"3-isopropylmalate dehydratase activity; 4 iron, 4 sulfur cluster binding; hydro-lyase activity; intramolecular transferase activity; leucine biosynthetic process; metal ion binding"," Binds 1 4Fe-4S cluster per subunit (By similarity)."]
["P60716","LIPA_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","lipA lip b0628 JW0623","Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)",321,"4 iron, 4 sulfur cluster binding; cytoplasm; lipoate synthase activity; metal ion binding; protein lipoylation"," Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine."]
["P69739","MBHS_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","hyaA b0972 JW0954","Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase)",372,"3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; ferredoxin hydrogenase activity; ferredoxin hydrogenase complex; hydrogenase (acceptor) activity; integral to membrane; metal ion binding; plasma membrane; quinone binding"," Binds 1 3Fe-4S cluster (By similarity).;  Binds 2 4Fe-4S clusters (By similarity).","3UQY;3USC;3USE;4GD3;"]
["P69741","MBHT_ECOLI","Electron transfert","Fontecave et al, 2008","HYBO","No iron-sulfur binding hit","hybO yghV b2997 JW2965","Hydrogenase-2 small chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 small subunit) (NiFe hydrogenase)",372,"3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; ferredoxin hydrogenase activity; ferredoxin hydrogenase complex; hydrogenase (acceptor) activity; membrane; metal ion binding; periplasmic space; plasma membrane; quinone binding"," Binds 1 3Fe-4S cluster (By similarity).;  Binds 2 4Fe-4S clusters (By similarity)."]
["P0AEI1","MIAB_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","miaB yleA b0661 JW0658","(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB (EC 2.-.-.-) (tRNA-i(6)A37 methylthiotransferase)",474,"4 iron, 4 sulfur cluster binding; cytoplasm; iron ion binding; tRNA modification; transferase activity"," Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Probable)."]
["P30745","MOAA_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","moaA bisA chlA chlA1 narA b0781 JW0764","Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A)",329,"4 iron, 4 sulfur cluster binding; GTP binding; Mo-molybdopterin cofactor biosynthetic process; lyase activity; metal ion binding; molybdopterin synthase complex"," Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate (By similarity).;  Binds 1 S-adenosyl-L-methionine per subunit (By similarity)."]
["P17802","MUTY_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008",null,"Endonuclease III, iron-sulphur binding site (IPR004035)","mutY micA b2961 JW2928","A/G-specific adenine glycosylase (EC 3.2.2.-)",350,"4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA binding; base-excision repair; endonuclease activity; hydrolase activity; intracellular; metal ion binding"," Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.","1KG2;1KG3;1KG4;1KG5;1KG6;1KG7;1KQJ;1MUD;1MUN;1MUY;1WEF;1WEG;1WEI;"]
["P11458","NADA_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nadA nicA b0750 JW0733","Quinolinate synthase A (EC 2.5.1.72)",347,"4 iron, 4 sulfur cluster binding; cytoplasm; de novo NAD biosynthetic process from aspartate; metal ion binding; quinolinate synthetase A activity; transferase activity, transferring alkyl or aryl (other than methyl) groups"," Binds 1 4Fe-4S cluster per subunit."]
["P33937","NAPA_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","napA yojC yojD yojE b2206 JW2194","Periplasmic nitrate reductase (EC 1.7.99.4)",828,"4 iron, 4 sulfur cluster binding; Mo-molybdopterin cofactor biosynthetic process; anaerobic respiration; electron carrier activity; electron transport chain; iron ion binding; molybdenum ion binding; nitrate assimilation; nitrate reductase activity; outer membrane-bounded periplasmic space; oxidoreductase activity, acting on NAD(P)H"," Binds 1 4Fe-4S cluster (By similarity).;  Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","2NYA;2PQ4;"]
["P0AAL0","NAPF_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900); Ferredoxin-type protein NapF (IPR004496)","napF yojG b2208 JW2196","Ferredoxin-type protein NapF",164,"4 iron, 4 sulfur cluster binding; anaerobic respiration; electron carrier activity; electron transport chain; iron ion binding"]
["P0AAL3","NAPG_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","napG yojA yojB b2205 JW2193","Ferredoxin-type protein NapG",231,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; oxidoreductase activity"]
["P33934","NAPH_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","napH yejZ b2204 JW2192","Ferredoxin-type protein NapH",287,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; integral to membrane; iron ion binding; membrane; plasma membrane"]
["P09152","NARG_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","narG bisD narC b1224 JW1215","Respiratory nitrate reductase 1 alpha chain (EC 1.7.99.4) (Nitrate reductase A subunit alpha) (Quinol-nitrate oxidoreductase subunit alpha)",1247,"4 iron, 4 sulfur cluster binding; anaerobic respiration; cytochrome complex assembly; electron carrier activity; electron transport chain; intrinsic to membrane; molybdenum ion binding; nitrate assimilation; nitrate reductase activity; nitrate reductase complex; oxidoreductase activity, acting on NAD(P)H; plasma membrane"," Binds 1 4Fe-4S cluster per subunit.;  Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","1Q16;1R27;1SIW;1Y4Z;1Y5I;1Y5L;1Y5N;3EGW;3IR5;3IR6;3IR7;"]
["P11349","NARH_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896)","narH b1225 JW1216","Respiratory nitrate reductase 1 beta chain (EC 1.7.99.4) (Nitrate reductase A subunit beta) (Quinol-nitrate oxidoreductase subunit beta)",512,"3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; anaerobic respiration; cytochrome complex assembly; electron carrier activity; electron transport chain; intrinsic to membrane; metal ion binding; nitrate assimilation; nitrate reductase activity; nitrate reductase complex; plasma membrane"," Binds 3 4Fe-4S clusters per subunit.;  Binds 1 3Fe-4S cluster per subunit.","1Q16;1R27;1SIW;1Y4Z;1Y5I;1Y5L;1Y5N;3EGW;3IR5;3IR6;3IR7;"]
["P19318","NARY_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896)","narY b1467 JW1462","Respiratory nitrate reductase 2 beta chain (EC 1.7.99.4)",514,"3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; anaerobic respiration; electron carrier activity; electron transport chain; metal ion binding; nitrate assimilation; nitrate reductase activity; nitrate reductase complex; plasma membrane; response to DNA damage stimulus"," Binds 3 4Fe-4S clusters per subunit (By similarity).;  Binds 1 3Fe-4S cluster per subunit (By similarity)."]
["P19319","NARZ_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","narZ b1468 JW1463","Respiratory nitrate reductase 2 alpha chain (EC 1.7.99.4)",1246,"4 iron, 4 sulfur cluster binding; anaerobic respiration; electron carrier activity; electron transport chain; iron ion binding; membrane; molybdenum ion binding; nitrate assimilation; nitrate reductase activity; nitrate reductase complex; oxidoreductase activity, acting on NAD(P)H; plasma membrane"," Binds 1 4Fe-4S cluster per subunit (By similarity).;  Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity)."]
["P63020","NFUA_ECOLI","Metallosite assembly","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nfuA gntY yhgI b3414 JW3377","Fe/S biogenesis protein NfuA",191,"4 iron, 4 sulfur cluster binding; carbon utilization; cellular response to iron ion starvation; iron ion binding; iron-sulfur cluster assembly; protein maturation; response to oxidative stress"," Binds 1 4Fe-4S cluster per subunit. The cluster is presumably bound at the interface of two monomers."]
["P0ACD4","NIFU_ECOLI","Metallosite assembly","Fontecave et al, 2008","ISCU","No iron-sulfur binding hit","nifU icsU yfhN b2529 JW2513","NifU-like protein",128,"2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; iron ion binding; iron-sulfur cluster assembly",null,"2KQK;2L4X;"]
["P08201","NIRB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"Nitrite/sulphite reductase 4Fe-4S domain (IPR006067); BFD-like [2Fe-2S]-binding domain (IPR007419)","nirB b3365 JW3328","Nitrite reductase (NADH) large subunit (EC 1.7.1.15)",847,"4 iron, 4 sulfur cluster binding; NADP binding; anaerobic respiration; flavin adenine dinucleotide binding; heme binding; iron-sulfur cluster binding; metal ion binding; nitrate assimilation; nitrite reductase [NAD(P)H] activity; nitrite reductase complex [NAD(P)H]"," Binds 1 siroheme per subunit.;  Binds 1 4Fe-4S cluster per subunit.;  FAD."]
["P0A9N8","NRDG_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nrdG yjgE b4237 JW4196","Anaerobic ribonucleoside-triphosphate reductase-activating protein (EC 1.97.1.-) (Class III anaerobic ribonucleotide reductase small component)",154,"4 iron, 4 sulfur cluster binding; [formate-C-acetyltransferase]-activating enzyme activity; anaerobic ribonucleoside-triphosphate reductase complex; metal ion binding; nucleobase-containing small molecule interconversion"," Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine."]
["P0AAK7","NRFC_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","nrfC yjcJ b4072 JW4033","Protein NrfC",223,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; nitrite reductase (cytochrome, ammonia-forming) activity"]
["P0A9E9","NSR_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008","YEIL","No iron-sulfur binding hit","yeiL nsr b2163 JW2150","Regulatory protein YeiL",219,"4 iron, 4 sulfur cluster binding; DNA binding; cytoplasm; metal ion binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent"," Binds 1 4Fe-4S cluster per subunit (Probable)."]
["P0AF63","NSRR_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nsrR yjeB b4178 JW4136","HTH-type transcriptional repressor NsrR",141,"2 iron, 2 sulfur cluster binding; DNA binding; double-stranded DNA binding; iron ion binding; iron-sulfur cluster binding; negative regulation of transcription, DNA-dependent; protein-DNA complex; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent"," Binds 1 2Fe-2S cluster per subunit (Potential)."]
["P0AFC7","NUOB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nuoB b2287 JW5875","NADH-quinone oxidoreductase subunit B (EC 1.6.99.5) (NADH dehydrogenase I subunit B) (NDH-1 subunit B) (NUO2)",220,"4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; aerobic respiration; electron transport coupled proton transport; iron ion binding; photosynthesis, light reaction; plasma membrane respiratory chain complex I; quinone binding"," Binds 1 4Fe-4S cluster (By similarity)."]
["P0AFD1","NUOE_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nuoE b2285 JW2280","NADH-quinone oxidoreductase subunit E (EC 1.6.99.5) (NADH dehydrogenase I subunit E) (NDH-1 subunit E) (NUO5)",166,"2 iron, 2 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I; plasma membrane respiratory chain complex I; quinone binding"," Binds 1 2Fe-2S cluster (Potential)."]
["P31979","NUOF_ECOLI","Electron transfert","Fontecave et al, 2008",null,"No iron-sulfur binding hit","nuoF b2284 JW2279","NADH-quinone oxidoreductase subunit F (EC 1.6.99.5) (NADH dehydrogenase I subunit F) (NDH-1 subunit F) (NUO6)",445,"4 iron, 4 sulfur cluster binding; FMN binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; aerobic respiration; metal ion binding; plasma membrane respiratory chain complex I; quinone binding"," Binds 1 FMN (Potential).;  Binds 1 4Fe-4S cluster (Potential)."]
["P33602","NUOG_ECOLI","Electron transfert","Fontecave et al, 2008",null,"2Fe-2S ferredoxin-type domain (IPR001041); Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","nuoG b2283 JW2278","NADH-quinone oxidoreductase subunit G (EC 1.6.99.5) (NADH dehydrogenase I subunit G) (NDH-1 subunit G) (NUO7)",908,"2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; aerobic respiration; electron carrier activity; molybdenum ion binding; plasma membrane respiratory chain complex I; quinone binding"," Binds 1 2Fe-2S cluster per subunit (By similarity).;  Binds 3 4Fe-4S clusters per subunit (By similarity)."]
["P0AFD6","NUOI_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","nuoI b2281 JW2276","NADH-quinone oxidoreductase subunit I (EC 1.6.99.5) (NADH dehydrogenase I subunit I) (NDH-1 subunit I) (NUO9)",180,"4 iron, 4 sulfur cluster binding; NADH dehydrogenase (quinone) activity; aerobic respiration; electron carrier activity; iron ion binding; photosynthesis, light reaction; plasma membrane respiratory chain complex I; quinone binding"," Binds 2 4Fe-4S clusters per subunit (By similarity)."]
["P0A9N4","PFLA_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","pflA act b0902 JW0885","Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 1) (PFL-activating enzyme 1)",246,"4 iron, 4 sulfur cluster binding; [formate-C-acetyltransferase]-activating enzyme activity; cytoplasm; glucose metabolic process; metal ion binding; oxidoreductase activity; response to DNA damage stimulus"," Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","3C8F;3CB8;"]
["P0AEI4","RIMO_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008","YLIG","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","rimO yliG b0835 JW0819","Ribosomal protein S12 methylthiotransferase RimO (S12 MTTase) (S12 methylthiotransferase) (EC 2.-.-.-) (Ribosome maturation factor RimO)",441,"4 iron, 4 sulfur cluster binding; RNA modification; aspartic acid methylthiotransferase activity; cytoplasm; iron ion binding"," Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity)."]
["P77223","RNFB_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S domain (IPR007202); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","rnfB ydgM b1628 JW1620","Electron transport complex protein RnfB",192,"2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; cytoplasm; electron carrier activity; electron transport chain; metal ion binding; plasma membrane"," Binds 1 2Fe-2S cluster (Potential).;  Binds 2 4Fe-4S clusters (Potential)."]
["P77611","RNFC_ECOLI","Electron transfert","Fontecave et al, 2008",null,"4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","rnfC ydgN b1629 JW1621","Electron transport complex protein RnfC",740,"4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; oxidoreductase activity, acting on NAD(P)H; plasma membrane"," Binds 2 4Fe-4S clusters per subunit (Potential)."]
["P55135","RUMA_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008","RLMD","No iron-sulfur binding hit","rlmD rumA ygcA b2785 JW2756","23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD (EC 2.1.1.190) (23S rRNA(m5U1939)-methyltransferase)",433,"4 iron, 4 sulfur cluster binding; RNA binding; iron ion binding; rRNA (uridine-C5-)-methyltransferase activity; rRNA base methylation",null,"1UWV;2BH2;"]
["P16095","SDHL_ECOLI","Non redox catalysis","Fontecave et al, 2008","SDAA","Iron-sulphur-dependent L-serine dehydratase single chain form (IPR004644)","sdaA b1814 JW1803","L-serine dehydratase 1 (SDH 1) (EC 4.3.1.17) (L-serine deaminase 1) (L-SD1)",454,"4 iron, 4 sulfur cluster binding; L-serine ammonia-lyase activity; L-serine catabolic process; gluconeogenesis; metal ion binding"," Binds 1 4Fe-4S cluster (Probable)."]
["P30744","SDHM_ECOLI","Non redox catalysis","Fontecave et al, 2008","SDAB","Iron-sulphur-dependent L-serine dehydratase single chain form (IPR004644)","sdaB b2797 JW2768","L-serine dehydratase 2 (SDH 2) (EC 4.3.1.17) (L-serine deaminase 2) (L-SD2)",455,"4 iron, 4 sulfur cluster binding; L-serine ammonia-lyase activity; L-serine catabolic process; gluconeogenesis; metal ion binding"," Binds 1 4Fe-4S cluster (Probable)."]
["P0ACS2","SOXR_ECOLI","Nucleic acid-binding proteins","Fontecave et al, 2008",null,"No iron-sulfur binding hit","soxR marC b4063 JW4024","Redox-sensitive transcriptional activator SoxR",154,"2 iron, 2 sulfur cluster binding; DNA binding; cytoplasm; iron ion binding; nucleotide binding; response to oxidative stress; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent",null,"2ZHG;2ZHH;"]
["P77667","SUFA_ECOLI","Metallosite assembly","Fontecave et al, 2008",null,"No iron-sulfur binding hit","sufA ydiC b1684 JW1674","Protein SufA",122,"2 iron, 2 sulfur cluster binding; iron-sulfur cluster assembly; response to oxidative stress; structural molecule activity",null,"2D2A;"]
["P77522","SUFB_ECOLI","Metallosite assembly","Fontecave et al, 2008",null,"No iron-sulfur binding hit","sufB ynhE b1683 JW5273","FeS cluster assembly protein SufB",495,"4 iron, 4 sulfur cluster binding; iron-sulfur cluster assembly"]
["P42630","TDCG_ECOLI","Non redox catalysis","Fontecave et al, 2008",null,"Iron-sulphur-dependent L-serine dehydratase single chain form (IPR004644)","tdcG yhaP yhaQ b4471 JW5520","L-serine dehydratase TdcG (SDH) (EC 4.3.1.17) (L-serine deaminase)",454,"4 iron, 4 sulfur cluster binding; L-serine ammonia-lyase activity; L-threonine catabolic process to propionate; cellular amino acid catabolic process; gluconeogenesis; metal ion binding"," Binds 1 4Fe-4S cluster (Probable)."]
["P30140","THIH_ECOLI","RadicalSAM - Redox Catalysis","Fontecave et al, 2008",null,"Radical SAM (IPR007197)","thiH b3990 JW3953","2-iminoacetate synthase (EC 4.1.99.19) (Dehydroglycine synthase) (Tyrosine lyase)",377,"2-iminoacetate synthase activity; 4 iron, 4 sulfur cluster binding; iron ion binding; response to DNA damage stimulus; thiamine diphosphate biosynthetic process"," Binds 1 4Fe-4S cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine."]
["Q46801","XDHC_ECOLI","Metallosite assembly","Fontecave et al, 2008",null,"2Fe-2S ferredoxin-type domain (IPR001041); [2Fe-2S]-binding (IPR002888)","xdhC ygeU b2868 JW2836","Xanthine dehydrogenase iron-sulfur-binding subunit",159,"2 iron, 2 sulfur cluster binding; electron carrier activity; hypoxanthine catabolic process; metal ion binding; oxidoreductase activity; purine ribonucleoside salvage"," Binds 2 2Fe-2S clusters (By similarity)."]
[]
[]
[]
["References:"]
["Fontecave M, Py B, Ollagnier de Choudens S and Barras F"]
["From iron and cysteine to iron-sulfur clusters: The biogenesis protein machineries. In Escherichia coli and Salmonella. 2008, Chapter 3.6.3.14, Editor Section: T. Begley"]

{"sheet":"Supplementary_Table_2","index":2,"n_rows":31,"n_cols":3,"rows_kept":31,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Source","Identifier","Description"]
["PFAM","PF00037","4Fe-4S binding domain"]
["PFAM","PF00111","2Fe-2S iron-sulfur cluster binding domain"]
["PFAM","PF00355","Rieske [2Fe-2S] domain"]
["PFAM","PF01077","Nitrite and sulphite reductase 4Fe-4S domain"]
["PFAM","PF01799","[2Fe-2S] binding domain"]
["PFAM","PF04055","Radical SAM superfamily"]
["PFAM","PF04060","Putative Fe-S cluster"]
["PFAM","PF04324","BFD-like [2Fe-2S] binding domain"]
["PFAM","PF04879","Molybdopterin oxidoreductase Fe4S4 domain"]
["PFAM","PF10576","Iron-sulfur binding domain of endonuclease III"]
["PFAM","PF10588","NADH-ubiquinone oxidoreductase-G iron-sulfur binding region"]
["PFAM","PF10589","NADH-ubiquinone oxidoreductase-F iron-sulfur binding region"]
["PFAM","PF11575","FhuF 2Fe-2S C-terminal domain"]
["PROSITE","PS00197","2Fe-2S ferredoxin-type iron-sulfur binding region signature"]
["PROSITE","PS00198","4Fe-4S ferredoxin-type iron-sulfur binding region signature"]
["PROSITE","PS00365","Nitrite and sulfite reductases iron-sulfur/siroheme-binding site"]
["PROSITE","PS00764","Endonuclease III iron-sulfur binding region signature"]
["PROSITE","PS00814","Adrenodoxin, iron-sulphur binding site"]
["PROSITE","PS01278","Methylthiotransferase radical SAM domain signature"]
["PROSITE","PS51085","2Fe-2S ferredoxin-type iron-sulfur binding domain profile"]
["PROSITE","PS51296","Rieske [2Fe-2S] iron-sulfur domain profile"]
["PROSITE","PS51379","4Fe-4S ferredoxin-type iron-sulfur binding domain profile"]
["SUPERFAMILY","SSF102114","Radical SAM enzymes superfamily"]
["SUPERFAMILY","SSF46548","alpha-helical ferredoxin superfamily"]
["SUPERFAMILY","SSF47741","CO dehydrogenase ISP C-domain like superfamily"]
["SUPERFAMILY","SSF50022","ISP domain superfamily"]
["SUPERFAMILY","SSF50023","Rieske iron-sulfur protein (ISP) family"]
["SUPERFAMILY","SSF53732","Aconitase iron-sulfur domain superfamily"]
["SUPERFAMILY","SSF54292","2Fe-2S ferredoxin-like superfamily"]
["SUPERFAMILY","SSF54862","4Fe-4S ferredoxins superfamily"]

{"sheet":"Supplementary_Table_3","index":3,"n_rows":94,"n_cols":6,"rows_kept":94,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["PDB identifier (sub_chain)","Entry Uniprot","Protein names","3D","General annotation (cofactor)","Keywords"]
["1a70_A","P00221","Ferredoxin-1, chloroplastic (Ferredoxin I) (Fd I)","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Chloroplast; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Plastid; Transit peptide; Transport"]
["1ao0_A","P00497","Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase)","X-ray crystallography (2)","COFACTOR: Binds 1 magnesium ion per subunit.; COFACTOR: Binds 1 4Fe-4S cluster per subunit. The 4Fe-4S cluster requires a potential lower than -600 mV for reduction.","3D-structure; 4Fe-4S; Allosteric enzyme; Complete proteome; Direct protein sequencing; Glutamine amidotransferase; Glycosyltransferase; Iron; Iron-sulfur; Magnesium; Metal-binding; Purine biosynthesis; Reference proteome; Transferase"]
["1awd_A","P56408","Ferredoxin","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Chloroplast; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Phosphoprotein; Plastid; Transport"]
["1b25_A","Q8U1K3","Formaldehyde:ferredoxin oxidoreductase","X-ray crystallography (2)",null,"3D-structure; 4Fe-4S; Calcium; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["1bc6_A","Q45560","Ferredoxin 7Fe (Seven-iron ferredoxin)","NMR spectroscopy (4)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 3Fe-4S cluster.","3D-structure; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding; Repeat; Transport"]
["1czp_A","P0A3C8","Ferredoxin-1 (Ferredoxin I)","X-ray crystallography (3)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1dax_A","P00210","Ferredoxin-1 (Ferredoxin I) (FdI)","X-ray crystallography (1); NMR spectroscopy (2)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1dgj_A","Q9REC4","Aldehyde oxidoreductase","X-ray crystallography (1)",null,"2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding"]
["1dj7_A","Q55389","Ferredoxin-thioredoxin reductase, catalytic chain (FTR-C) (EC 1.8.7.2) (Ferredoxin-thioredoxin reductase subunit B) (FTR-B)","X-ray crystallography (7)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; Complete proteome; Disulfide bond; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Redox-active center; Reference proteome; Transport"]
["1doi_A","P00217","Ferredoxin-1","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1dwl_A","P07485","Ferredoxin-1 (Ferredoxin I) (FdI)","NMR spectroscopy (1)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1e6e_B","P00257","Adrenodoxin (Adrenal ferredoxin) (Ferredoxin-1) (Hepato-ferredoxin)","NMR spectroscopy (3); X-ray crystallography (4)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Acetylation; Alternative splicing; Cholesterol metabolism; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Lipid metabolism; Metal-binding; Mitochondrion; Reference proteome; Steroid metabolism; Steroidogenesis; Sterol metabolism; Transit peptide; Transport"]
["1f2g_A","P00209","Ferredoxin-2 (Ferredoxin II) (FdII)","X-ray crystallography (1); NMR spectroscopy (1)","COFACTOR: Binds 1 3Fe-4S cluster in its tetrameric form.; COFACTOR: Binds 1 4Fe-4S cluster in its dimeric form.","3D-structure; 3Fe-4S; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Metal-binding; Methylation; Repeat; Transport"]
["1fqt_A","P37332","Biphenyl dioxygenase system ferredoxin subunit","X-ray crystallography (1)",null,"2Fe-2S; 3D-structure; Aromatic hydrocarbons catabolism; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1frd_A","P11053","Ferredoxin, heterocyst","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Complete proteome; Electron transport; Heterocyst; Iron; Iron-sulfur; Metal-binding; Nitrogen fixation; Transport"]
["1frr_A","P00235","Ferredoxin-1 (Ferredoxin I)","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Chloroplast; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Plastid; Transport"]
["1g8k_B","Q7SIF3","Arsenite oxidase subunit AioB (AOII) (EC 1.20.9.1) (Arsenite oxidase Rieske subunit)","X-ray crystallography (2)","COFACTOR: Binds 1 2Fe-2S cluster per subunit.","2Fe-2S; 3D-structure; Direct protein sequencing; Disulfide bond; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Signal"]
["1gnl_A","Q01770","Hydroxylamine reductase (EC 1.7.-.-) (HCP) (Hybrid-cluster protein) (Prismane protein)","X-ray crystallography (4)","COFACTOR: Binds 1 spin-admixed 4Fe-4S cluster.; COFACTOR: Binds 1 hybrid 4Fe-2O-2S cluster.","3D-structure; 4Fe-4S; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Oxidoreductase"]
["1gnt_A","P31101","Hydroxylamine reductase (EC 1.7.-.-) (HCP) (Hybrid-cluster protein) (Prismane protein)","X-ray crystallography (6)","COFACTOR: Binds 1 spin-admixed 4Fe-4S cluster.; COFACTOR: Binds 1 hybrid 4Fe-2O-2S cluster.","3D-structure; 4Fe-4S; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["1h0h_A","Q934F5","Formate dehydrogenase subunit alpha (FDH subunit alpha) (EC 1.2.1.2) (Formate dehydrogenase large subunit)","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster per subunit.; COFACTOR: Binds 1 tungsten-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.","3D-structure; 4Fe-4S; Calcium; Disulfide bond; Electron transport; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Periplasm; Selenocysteine; Signal; Transport; Tungsten"]
["1h2a_S","P21853","Periplasmic [NiFe] hydrogenase small subunit (EC 1.12.2.1) (NiFe hydrogenlyase small chain)","X-ray crystallography (16)","COFACTOR: Binds 2 4Fe-4S clusters.; COFACTOR: Binds 1 3Fe-4S cluster.","3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Periplasm; Signal"]
["1h98_A","P03942","Ferredoxin","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 3Fe-4S cluster.","3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["1hlq_A","P80882","High-potential iron-sulfur protein (HiPIP)","X-ray crystallography (1)",null,"3D-structure; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1iqz_A","P10245","Ferredoxin","X-ray crystallography (3)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1iue_A","Q8IED5","Ferredoxin, putative","X-ray crystallography (1)",null,"2Fe-2S; 3D-structure; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["1jm1_A","Q53766","Rieske protein","X-ray crystallography (1)",null,"2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding"]
["1jnr_B","O28604","Adenylylsulfate reductase, subunit B (AprB)","X-ray crystallography (6)",null,"  "]
["1jq4_A","P22868","Methane monooxygenase component C (EC 1.14.13.25) (Methane hydroxylase) (Methane monooxygenase reductase) (MMOR)","NMR spectroscopy (2)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Monooxygenase; NADP; One-carbon metabolism; Oxidoreductase; Transport"]
["1krh_A","P07771","Benzoate 1,2-dioxygenase electron transfer component [Includes: Ferredoxin; Ferredoxin--NAD(+) reductase (EC 1.18.1.3)]","X-ray crystallography (1)","COFACTOR: FAD.; COFACTOR: Binds 1 2Fe-2S cluster per subunit (By similarity).","2Fe-2S; 3D-structure; Aromatic hydrocarbons catabolism; Complete proteome; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase"]
["1l5p","P21149","Ferredoxin","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Direct protein sequencing; Electron transport; Hydrogenosome; Iron; Iron-sulfur; Metal-binding; Transport"]
["1m2d_A","O66511","Ferredoxin, 2Fe-2S (AaFd4)","X-ray crystallography (4)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["1noe_A","P00260","High-potential iron-sulfur protein (HiPIP)","NMR spectroscopy (4); X-ray crystallography (4)",null,"3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Periplasm; Signal; Transport"]
["1o94_A","P16099","Trimethylamine dehydrogenase (TMADh) (EC 1.5.8.2)","X-ray crystallography (5)","COFACTOR: Binds 1 FMN covalently per subunit.; COFACTOR: Binds 1 4Fe-4S cluster per subunit.","3D-structure; 4Fe-4S; Direct protein sequencing; FMN; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Oxidoreductase"]
["1oao_A","P27988","Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha (ACS subunit) (Acetyl-CoA synthase subunit) (CODH/ACS) (EC 2.3.1.169)","X-ray crystallography (7)","COFACTOR: Binds 2 nickel ions per subunit.; COFACTOR: Binds 1 4Fe-4S cluster per subunit.","3D-structure; 4Fe-4S; Carbon dioxide fixation; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Nickel; Transferase"]
["1oao_C","P27989","Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit beta (CODH subunit) (CODH/ACS) (Carbon monoxide dehydrogenase subunit) (EC 1.2.7.4) (EC 1.2.99.2)","X-ray crystallography (5)","COFACTOR: Binds 1 nickel-iron-sulfur cluster per subunit.; COFACTOR: Binds 2 4Fe-4S clusters per homodimer.","3D-structure; 4Fe-4S; Carbon dioxide fixation; Electron transport; Iron; Iron-sulfur; Metal-binding; Nickel; Oxidoreductase; Transport"]
["1ogy_A","Q53176","Periplasmic nitrate reductase (EC 1.7.99.4)","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster (By similarity).; COFACTOR: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","3D-structure; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Periplasm; Plasmid; Reference proteome; Signal; Transport"]
["1ohv_A","P80147","4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)","X-ray crystallography (3)","COFACTOR: Pyridoxal phosphate.","3D-structure; Acetylation; Aminotransferase; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Neurotransmitter degradation; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide"]
["1pp9_E","P13272","Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]","Electron microscopy (1); X-ray crystallography (20)","COFACTOR: Binds 1 2Fe-2S cluster per subunit.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix; Transport"]
["1rfs_A","P08980","Cytochrome b6-f complex iron-sulfur subunit, chloroplastic (EC 1.10.9.1) (Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein) (Rieske iron-sulfur protein) (ISP) (RISP)","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster per subunit.","2Fe-2S; 3D-structure; Chloroplast; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Plastid; Thylakoid; Transit peptide; Transmembrane; Transmembrane helix; Transport"]
["1rie_A","P13272","Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]","Electron microscopy (1); X-ray crystallography (20)","COFACTOR: Binds 1 2Fe-2S cluster per subunit.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix; Transport"]
["1rof_A","P46797","Ferredoxin","X-ray crystallography (1); NMR spectroscopy (1)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["1sj1_A","P29603","Ferredoxin","X-ray crystallography (5)","COFACTOR: Binds 1 4Fe-4S cluster which readily converts to a stable 3Fe-4S form.","3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Disulfide bond; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["1su8_A","Q9F8A8","Carbon monoxide dehydrogenase 2 (CODH 2) (EC 1.2.99.2)","X-ray crystallography (9)","COFACTOR: Binds 3 4Fe-4S clusters per homodimer.; COFACTOR: Binds 2 nickel-iron-sulfur clusters per homodimer.","3D-structure; 4Fe-4S; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Nickel; Oxidoreductase"]
["1tv8_A","P69848","Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A)","X-ray crystallography (4)","COFACTOR: Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate.; COFACTOR: Binds 1 S-adenosyl-L-methionine per subunit.","3D-structure; 4Fe-4S; Complete proteome; GTP-binding; Iron; Iron-sulfur; Lyase; Metal-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding; Reference proteome; S-adenosyl-L-methionine"]
["1uwm_A","P80306","Ferredoxin-6 (Ferredoxin VI) (FdVI)","X-ray crystallography (2)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1v97_A","P80457","Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]","X-ray crystallography (23)","COFACTOR: Binds 2 2Fe-2S clusters.; COFACTOR: FAD.; COFACTOR: Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.","2Fe-2S; 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; Glycoprotein; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Peroxisome; Reference proteome; Secreted"]
["1vf5_D","P83794","Cytochrome b6-f complex iron-sulfur subunit (EC 1.10.9.1) (Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein) (ISP) (RISP) (Rieske iron-sulfur protein)","X-ray crystallography (8)","COFACTOR: Binds 1 2Fe-2S cluster per subunit.","2Fe-2S; 3D-structure; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Thylakoid; Transmembrane; Transmembrane helix; Transport"]
["1vk2_A","Q9WYY1","Phage SPO1 DNA polymerase-related protein (Uncharacterized protein) (Uracil-DNA glycosylase, family 4)","X-ray crystallography (2)",null,"3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["1vlb_A","Q46509","Aldehyde oxidoreductase (EC 1.2.99.7) (Molybdenum iron sulfur protein)","X-ray crystallography (5)","COFACTOR: Binds 1 molybdenum-molybdopterin cytosine dinucleotide (Mo-MCD) cofactor per subunit.; COFACTOR: Binds 2 2Fe-2S clusters per subunit.","2Fe-2S; 3D-structure; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase"]
["1vm9_A","Q00458","Toluene-4-monooxygenase system ferredoxin subunit (Toluene-4-monooxygenase system protein C) (T4moC)","X-ray crystallography (2); NMR spectroscopy (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Aromatic hydrocarbons catabolism; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport"]
["1wql_A","Q51743","Iron-sulfur protein large subunit of cumene dioxygenase","X-ray crystallography (1)",null,"2Fe-2S; 3D-structure; Dioxygenase; Iron; Iron-sulfur; Metal-binding; Oxidoreductase"]
["1wri_A","P00237","Ferredoxin-2 (Ferredoxin II)","X-ray crystallography (1)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Chloroplast; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Plastid; Transport"]
["1xer_A","P55907","Zinc-containing ferredoxin-1","X-ray crystallography (1)","COFACTOR: Binds 1 3Fe-4S cluster.; COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 zinc ion.","3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Methylation; Repeat; Transport; Zinc"]
["1z01_A","O05935","2-oxo-1,2-dihydroquinoline 8-monooxygenase, oxygenase component","X-ray crystallography (3)",null,"2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding; Monooxygenase; Oxidoreductase"]
["2afh_E","P00459","Nitrogenase iron protein 1 (EC 1.18.6.1) (Nitrogenase Fe protein 1) (Nitrogenase component II) (Nitrogenase reductase)","X-ray crystallography (20)","COFACTOR: Binds 1 4Fe-4S cluster per dimer.","3D-structure; 4Fe-4S; ADP-ribosylation; ATP-binding; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Nitrogen fixation; Nucleotide-binding; Oxidoreductase"]
["2auv_A","Q46505","NADP-reducing hydrogenase subunit HndA (EC 1.12.1.3) (Hydrogen dehydrogenase (NADP(+)))","NMR spectroscopy (1)","COFACTOR: Binds 1 2Fe-2S cluster (By similarity).","2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase"]
["2b1x_A","Q9X3R9","Naphthalene dioxygenase large subunit","X-ray crystallography (2)",null,"2Fe-2S; 3D-structure; Dioxygenase; Iron; Iron-sulfur; Metal-binding; Oxidoreductase"]
["2bmo_A","Q8RTL4","Oxygenase-alpha NBDO","X-ray crystallography (3)",null,"2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding"]
["2bs2_B","P17596","Fumarate reductase iron-sulfur subunit (EC 1.3.99.1)","X-ray crystallography (5)","COFACTOR: Binds 1 2Fe-2S cluster.; COFACTOR: Binds 1 3Fe-4S cluster.; COFACTOR: Binds 1 4Fe-4S cluster.","2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Respiratory chain; Transport; Tricarboxylic acid cycle"]
["2c42_A","P94692","Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)","X-ray crystallography (10)",null,"3D-structure; 4Fe-4S; Calcium; Chloride; Electron transport; Iron; Iron-sulfur; Magnesium; Metal-binding; Oxidoreductase; Pyruvate; Thiamine pyrophosphate; Transport"]
["2d3y_A","Q5SJ65","Uracil-DNA glycosylase","X-ray crystallography (4)",null,"3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["2de6_A","Q84II6","Terminal oxygenase component of carbazole","X-ray crystallography (7)",null,"2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding"]
["2de6_D","Q8GI16","Ferredoxin CarAc (Carbazole 1,9a-dioxygenase, ferredoxin component) (CARDO)","X-ray crystallography (7)","COFACTOR: Binds 1 2Fe-2S cluster per subunit.","2Fe-2S; 3D-structure; Dioxygenase; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Plasmid"]
["2e7p_A","Q5PSJ1","Glutaredoxin","X-ray crystallography (1); NMR spectroscopy (2)",null,"2Fe-2S; 3D-structure; Iron; Iron-sulfur; Metal-binding"]
["2e7z_A","Q71EW5","Acetylene hydratase (Ahy) (EC 4.2.1.112)","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 tungsten-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.","3D-structure; 4Fe-4S; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Tungsten"]
["2fdn_A","P00198","Ferredoxin","X-ray crystallography (3)","COFACTOR: Binds 2 4Fe-4S clusters.","3D-structure; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Repeat; Transport"]
["2fgo_A","Q9I6D2","Ferredoxin (4Fe-4S)","X-ray crystallography (1)",null,"3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["2g36_A","Q9WYW2","Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)","X-ray crystallography (1)",null,"3D-structure; ATP-binding; Aminoacyl-tRNA synthetase; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome"]
["2gbw_A","A2TC87","Biphenyl/naphthalene dioxygenase alpha subunit","X-ray crystallography (2)",null,"2Fe-2S; 3D-structure; Dioxygenase; Iron; Iron-sulfur; Metal-binding; Oxidoreductase"]
["2gmh_A","P55931","Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)","X-ray crystallography (2)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: FAD.","3D-structure; 4Fe-4S; Acetylation; Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide; Transport; Ubiquinone"]
["2goy_A","O05927","Phosphoadenosine phosphosulfate reductase (EC 1.8.4.8) (3'-phosphoadenylylsulfate reductase) (PAPS reductase, thioredoxin dependent) (PAPS sulfotransferase) (PAdoPS reductase)","X-ray crystallography (1)",null,"3D-structure; Complete proteome; Cytoplasm; Oxidoreductase; Reference proteome"]
["2ht9_A","Q9NS18","Glutaredoxin-2","X-ray crystallography (2); NMR spectroscopy (1)",null,"2Fe-2S; 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Electron transport; Glutathionylation; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Nucleus; Polymorphism; Redox-active center; Reference proteome; Transit peptide; Transport"]
["2ivf_A","Q5P5I0","Alpha-subunit of ethylbenzene dehydrogenase","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster (By similarity).; COFACTOR: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase"]
["2ivf_B","Q5P5I1","Beta-subunit of ethylbenzene dehydrogenase","X-ray crystallography (1)",null,"3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding"]
["2jh3_A","Q9RS86","Ribosomal protein S2-related protein","X-ray crystallography (1)",null,"3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Ribonucleoprotein; Ribosomal protein"]
["2nap_A","P81186","Periplasmic nitrate reductase (EC 1.7.99.4)","X-ray crystallography (8)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Periplasm; Signal; Transport"]
["2pia_A","P33164","Phthalate dioxygenase reductase (PDR) (EC 1.-.-.-)","X-ray crystallography (1)","COFACTOR: FMN; Binds 1 2Fe-2S cluster","2Fe-2S; 3D-structure; Direct protein sequencing; Electron transport; FMN; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Transport"]
["2v2k_A","P00215","Ferredoxin","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 3Fe-4S cluster.","3D-structure; 3Fe-4S; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Repeat; Transport"]
["2v4j_A","P45574","Sulfite reductase, dissimilatory-type subunit alpha (EC 1.8.99.3) (Desulfoviridin subunit alpha) (Hydrogensulfite reductase subunit alpha)","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster per subunit.; COFACTOR: Binds 2 sirohemes per subunit.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Heme; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["2v4j_B","P45575","Sulfite reductase, dissimilatory-type subunit beta (EC 1.8.99.3) (Desulfoviridin subunit beta) (Hydrogensulfite reductase subunit beta)","X-ray crystallography (1)","COFACTOR: Binds 1 4Fe-4S cluster per subunit.; COFACTOR: Binds 2 sirohemes per subunit.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["2vdc_G","Q05756","Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (NADPH-GOGAT)","Electron microscopy (1)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; Amino-acid biosynthesis; Direct protein sequencing; Glutamate biosynthesis; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase"]
["2vpz_A","Q72LA4","Thiosulfate reductase (EC 1.-.-.-)","X-ray crystallography (4)","COFACTOR: Binds 1 4Fe-4S cluster (By similarity).; COFACTOR: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase"]
["2vpz_B","Q72LA5","NrfC protein","X-ray crystallography (4)",null,"3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding"]
["2vsf_A","Q9HM14","ATP-dependent DNA helicase Ta0057 (EC 3.6.4.12)","X-ray crystallography (2)","COFACTOR: Binds 1 4Fe-4S cluster.","3D-structure; 4Fe-4S; ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Reference proteome; Transcription; Transcription regulation"]
["2w3s_A","O54050","Xanthine dehydrogenase (EC 1.1.1.204)","X-ray crystallography (6)",null,"2Fe-2S; 3D-structure; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Oxidoreductase"]
["2wpn_A","Q72AS4","Periplasmic [NiFeSe] hydrogenase, small subunit (EC 1.12.7.2)","X-ray crystallography (6)","COFACTOR: Binds 1 3Fe-4S cluster (By similarity).; COFACTOR: Binds 2 4Fe-4S clusters (By similarity).","3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase"]
["2wpn_B","Q72AS3","Periplasmic [NiFeSe] hydrogenase, large subunit, selenocysteine-containing (EC 1.12.7.2)","X-ray crystallography (6)",null,"3D-structure; 4Fe-4S; Chloride; Complete proteome; Iron; Iron-sulfur; Metal-binding; Nickel; Oxidoreductase; Selenium; Selenocysteine"]
["3iix_A","Q9X0Z6","Biotin synthase-related enzyme (Biotin synthetase, putative) (Radical SAM domain protein)","X-ray crystallography (10)","COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Chloride; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["7fd1_A","P00214","Ferredoxin-1 (Ferredoxin I) (FdI)","X-ray crystallography (32)","COFACTOR: Binds 1 4Fe-4S cluster.; COFACTOR: Binds 1 3Fe-4S cluster.","3D-structure; 3Fe-4S; 4Fe-4S; DNA-binding; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Repeat; Transport"]
["1uli_A","Q53122","Biphenyl 2,3-dioxygenase alpha subunit (EC 1.14.12.18) (Biphenyl dioxygenase)","X-ray crystallography (2)",null,"2Fe-2S; 3D-structure; Complete proteome; Dioxygenase; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Plasmid"]
["2bt6_A","P00257","Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepato-ferredoxin)","NMR spectroscopy (3); X-ray crystallography (4)","COFACTOR: Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Acetylation; Alternative splicing; Cholesterol metabolism; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Lipid metabolism; Metal-binding; Mitochondrion; Reference proteome; Steroid metabolism; Steroidogenesis; Sterol metabolism; Transit peptide; Transport"]
["1wui_S","P21853","Periplasmic [NiFe] hydrogenase small subunit (EC 1.12.2.1) (NiFe hydrogenlyase small chain)","X-ray crystallography (16)","COFACTOR: Binds 2 4Fe-4S clusters.; COFACTOR: Binds 1 3Fe-4S cluster.","3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Periplasm; Signal"]
["1h0h_B","Q8GC87","Formate dehydrogenase subunit beta (FDH subunit beta) (Formate dehydrogenase small subunit)","X-ray crystallography (1)","COFACTOR: Binds 3 4Fe-4S clusters.","3D-structure; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Periplasm; Repeat; Transport"]

{"sheet":"Supplementary_Table_4","index":4,"n_rows":159,"n_cols":8,"rows_kept":159,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Entry name (UniProtKB)","InFeS Score Mixed Model","Status","FeS annotation source ","Functional class","General annotation (cofactor)","Protein names","Keywords"]
["ACON1_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster per subunit (By similarity).","Aconitate hydratase 1 (Aconitase 1) (EC 4.2.1.3) (Citrate hydro-lyase 1)","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["ACON2_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster per subunit.","Aconitate hydratase 2 (Aconitase) (EC 4.2.1.3) (2-methylisocitrate dehydratase) (EC 4.2.1.99) (Citrate hydro-lyase)","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["AEGA_ECOLI",0.97178644364311,"TP","Uniprot",null,"Binds 4 4Fe-4S clusters (By similarity).","Protein AegA","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat"]
["AHPF_ECOLI",0.636763153634472,"FP","Uniprot",null,"Binds 1 FAD per subunit (By similarity).","Alkyl hydroperoxide reductase subunit F (EC 1.8.1.-) (Alkyl hydroperoxide reductase F52A protein)","3D-structure; Acetylation; Complete proteome; Disulfide bond; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Redox-active center; Reference proteome"]
["ASLB_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).; May bind at least one other iron-sulfur cluster (Potential).","Anaerobic sulfatase-maturating enzyme homolog AslB (AnSME homolog)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["BFD_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.","Bacterioferritin-associated ferredoxin","2Fe-2S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["BIOB_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; Binds 1 2Fe-2S cluster. The cluster is coordinated with 3 cysteines and 1 arginine.","Biotin synthase (EC 2.8.1.6)","2Fe-2S; 3D-structure; 4Fe-4S; Biotin biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase"]
["BISC_ECOLI",0.842933122896432,"FP","Uniprot",null,"Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (Probable).","Biotin sulfoxide reductase (BDS reductase) (BSO reductase) (EC 1.-.-.-) (L-methionine-(S)-sulfoxide reductase) (Met-S-SO reductase) (EC 1.8.4.13)","Complete proteome; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome"]
["CYSI_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Binds 1 siroheme per subunit.; Binds 1 4Fe-4S cluster per subunit.","Sulfite reductase [NADPH] hemoprotein beta-component (SiR-HP) (SiRHP) (EC 1.8.1.2)","3D-structure; 4Fe-4S; Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Direct protein sequencing; Heme; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["DHSB_ECOLI",0.997326982022507,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.; Binds 1 3Fe-4S cluster.; Binds 1 4Fe-4S cluster.","Succinate dehydrogenase iron-sulfur subunit (EC 1.3.99.1)","2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Transport; Tricarboxylic acid cycle"]
["DING_ECOLI","<0.5","FN","Ren et al, 2008",null,"Binds 1 4Fe-4S cluster.","Probable ATP-dependent helicase DinG (EC 3.6.4.12) (DNA-damage-inducible protein G)","4Fe-4S; ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Reference proteome"]
["DMSA_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","Dimethyl sulfoxide reductase DmsA (DMSO reductase) (DMSOR) (Me2SO reductase) (EC 1.8.5.3)","4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome; Signal"]
["DMSB_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","Binds 4 4Fe-4S clusters.","Anaerobic dimethyl sulfoxide reductase chain B (DMSO reductase iron-sulfur subunit)","4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["END3_ECOLI",0.713087017924912,"TP","Fontecave et al, 2008","Nucleic acid-binding proteins","Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in DNA-binding and proper positioning of the enzyme along the DNA strand.","Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase)","3D-structure; 4Fe-4S; Complete proteome; DNA damage; DNA repair; DNA-binding; Direct protein sequencing; Glycosidase; Hydrolase; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["ERPA_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","Binds 1 iron-sulfur cluster per subunit. A study found 40-50% as 2Fe-2S clusters, 15-25% as 4Fe-4S clusters and the rest as paramagnetic iron.","Iron-sulfur cluster insertion protein ErpA","Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["ETP_ECOLI",0.696334411797153,"FP","Uniprot",null,"No annotation","Low molecular weight protein-tyrosine-phosphatase etp (EC 3.1.3.48)","Complete proteome; Hydrolase; Protein phosphatase; Reference proteome"]
["FADH_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","FAD.","2,4-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34) (2,4-dienoyl coenzyme A reductase)","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["FDHD_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","No annotation","Protein FdhD","Complete proteome; Cytoplasm; Reference proteome"]
["FDHF_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster per subunit.; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","Formate dehydrogenase H (EC 1.1.99.33) (EC 1.2.1.2) (Formate dehydrogenase-H subunit alpha) (FDH-H) (Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide)","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Reference proteome; Selenocysteine"]
["FDNG_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.; Binds 1 4Fe-4S cluster per subunit.","Formate dehydrogenase, nitrate-inducible, major subunit (EC 1.2.1.2) (Anaerobic formate dehydrogenase major subunit) (Formate dehydrogenase-N subunit alpha) (FDH-N subunit alpha)","3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Periplasm; Reference proteome; Selenocysteine; Signal"]
["FDNH_ECOLI",0.951435219977823,"TP","Fontecave et al, 2008","Electron transfert","Binds 4 4Fe-4S clusters per subunit.","Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (Anaerobic formate dehydrogenase iron-sulfur subunit) (Formate dehydrogenase-N subunit beta) (FDH-N subunit beta)","3D-structure; 4Fe-4S; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["FDOG_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).; Binds 1 4Fe-4S cluster (Potential).","Formate dehydrogenase-O major subunit (EC 1.2.1.2) (Aerobic formate dehydrogenase major subunit) (FDH-Z subunit alpha) (Formate dehydrogenase-O subunit alpha)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Periplasm; Reference proteome; Selenocysteine; Signal"]
["FDOH_ECOLI",0.951435219977823,"TP","Fontecave et al, 2008","Electron transfert","Binds 4 4Fe-4S clusters per subunit (By similarity).","Formate dehydrogenase-O iron-sulfur subunit (Aerobic formate dehydrogenase iron-sulfur subunit) (FDH-Z subunit beta) (Formate dehydrogenase-O subunit beta)","4Fe-4S; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["FER_ECOLI",0.940177257236739,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.","2Fe-2S ferredoxin","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["FHUF_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.","Ferric iron reductase protein FhuF","2Fe-2S; Cell membrane; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome"]
["FIXX_ECOLI",0.961614515827717,"TP","Uniprot",null,"No annotation","Ferredoxin-like protein FixX","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["FNR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","Binds 1 4Fe-4S cluster per subunit.","Fumarate and nitrate reduction regulatory protein","4Fe-4S; Activator; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation"]
["FRDB_ECOLI",0.998585356798498,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.; Binds 1 3Fe-4S cluster.; Binds 1 4Fe-4S cluster.","Fumarate reductase iron-sulfur subunit (EC 1.3.99.1)","2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Transport; Tricarboxylic acid cycle"]
["FRLB_ECOLI",0.596937535802293,"FP","Uniprot",null,"No annotation","Fructoselysine 6-phosphate deglycase (EC 3.5.-.-)","Complete proteome; Hydrolase; Reference proteome; Repeat"]
["FUMA_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster.","Fumarate hydratase class I, aerobic (Fumarase) (EC 4.2.1.2)","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["FUMB_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster.","Fumarate hydratase class I, anaerobic (Fumarase) (EC 4.2.1.2)","4Fe-4S; Acetylation; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["GLCF_ECOLI",0.934798102230775,"TP","Uniprot",null,"No annotation","Glycolate oxidase iron-sulfur subunit","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["GLPB_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","FMN","Anaerobic glycerol-3-phosphate dehydrogenase subunit B (Anaerobic G-3-P dehydrogenase subunit B) (Anaerobic G3Pdhase B) (EC 1.1.5.3)","Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; FMN; Flavoprotein; Membrane; Oxidoreductase; Reference proteome"]
["GLPC_ECOLI",0.9603216697941,"TP","Uniprot",null,"No annotation","Anaerobic glycerol-3-phosphate dehydrogenase subunit C (G-3-P dehydrogenase)","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transport"]
["GLRX4_ECOLI","<0.5","FN","Uniprot",null,"No annotation","Glutaredoxin-4 (Grx4) (Monothiol glutaredoxin)","2Fe-2S; 3D-structure; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Redox-active center; Reference proteome"]
["GLTB_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Binds 1 3Fe-4S cluster.; FAD.; FMN.","Glutamate synthase [NADPH] large chain (EC 1.4.1.13) (Glutamate synthase subunit alpha) (GLTS alpha chain) (NADPH-GOGAT)","3Fe-4S; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; FAD; FMN; Flavoprotein; Glutamate biosynthesis; Glutamine amidotransferase; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome; Zymogen"]
["GLTD_ECOLI",0.812803505410347,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster.","Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (NADPH-GOGAT)","4Fe-4S; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; Glutamate biosynthesis; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["GMHA_ECOLI",0.596937535802293,"FP","Uniprot",null,"Binds 1 zinc ion per subunit (By similarity).","Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphate isomerase)","3D-structure; Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase; Lipopolysaccharide biosynthesis; Metal-binding; Reference proteome; Zinc"]
["HCAC_ECOLI",0.93798742857773,"TP","Fontecave et al, 2008","Electron transfert","No annotation","3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit (Digoxigenin ferredoxin subunit)","2Fe-2S; Aromatic hydrocarbons catabolism; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["HCAE_ECOLI",0.93798742857773,"TP","Uniprot",null,"Binds 1 2Fe-2S cluster (Probable).; Binds 1 iron ion (Probable).","3-phenylpropionate/cinnamic acid dioxygenase subunit alpha (EC 1.14.12.19) (Digoxigenin subunit alpha)","2Fe-2S; Aromatic hydrocarbons catabolism; Complete proteome; Dioxygenase; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome"]
["HCP_ECOLI",0.911889950004889,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.; Binds 1 hybrid 4Fe-2O-2S cluster.","Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP)","2Fe-2S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["HCR_ECOLI",0.940177257236739,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster.; FAD.","NADH oxidoreductase hcr (EC 1.-.-.-)","2Fe-2S; Complete proteome; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transport"]
["HEMN_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","Oxygen-independent coproporphyrinogen-III oxidase (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.99.22)","3D-structure; 4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; Reference proteome; S-adenosyl-L-methionine"]
["HYBA_ECOLI",0.998857109727891,"TP","Fontecave et al, 2008","Electron transfert","Binds 4 4Fe-4S clusters (By similarity).","Hydrogenase-2 operon protein HybA","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Periplasm; Reference proteome; Repeat; Signal"]
["HYCB_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","Binds 4 4Fe-4S clusters (By similarity).","Formate hydrogenlyase subunit 2 (FHL subunit 2) (Hydrogenase-3 component B)","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["HYCE_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster (Potential).; Nickel (Potential).","Formate hydrogenlyase subunit 5 (FHL subunit 5) (Hydrogenase-3 component E)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; NAD; Nickel; Oxidoreductase; Reference proteome"]
["HYCF_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","No annotation","Formate hydrogenlyase subunit 6 (FHL subunit 6) (Hydrogenase-3 component F)","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["HYCG_ECOLI",0.76695393168643,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster (Potential).","Formate hydrogenlyase subunit 7 (FHL subunit 7) (Hydrogenase-3 component G)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["HYDN_ECOLI",0.951435219977823,"TP","Uniprot",null,"Binds 4 4Fe-4S clusters (By similarity).","Electron transport protein HydN","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["HYFA_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","Binds 4 4Fe-4S clusters (By similarity).","Hydrogenase-4 component A (EC 1.-.-.-)","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat; Transport"]
["HYFG_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster.","Hydrogenase-4 component G (EC 1.-.-.-)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome"]
["HYFH_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","No annotation","Hydrogenase-4 component H","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["HYFI_ECOLI",0.76695393168643,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster (Potential).","Hydrogenase-4 component I (EC 1.-.-.-)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["HYFR_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","No annotation","Hydrogenase-4 transcriptional activator","ATP-binding; Activator; Complete proteome; DNA-binding; Nucleotide-binding; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system"]
["ILVD_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster.","Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9)","4Fe-4S; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["ISCA_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","Binds 2 iron ions per dimer. The dimer may bind additional iron ions.","Iron-binding protein IscA (Iron-sulfur cluster assembly protein)","3D-structure; Complete proteome; Iron; Metal-binding; Reference proteome"]
["ISCR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","Binds 1 2Fe-2S cluster; whether or not the Fe-S cluster is necessary for transcriptional regulation depends on the type of IscR-binding sequence (PubMed:16677314).","HTH-type transcriptional regulator IscR","2Fe-2S; 3D-structure; Activator; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Stress response; Transcription; Transcription regulation"]
["ISPG_ECOLI","<0.5","FN","Fontecave et al, 2008","Redox Catalysis","Binds 1 4Fe-4S cluster.","4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein GcpE) (Protein E)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis; Metal-binding; Oxidoreductase; Reference proteome"]
["ISPH_ECOLI","<0.5","FN","Fontecave et al, 2008","Redox Catalysis","Binds 1 3Fe-4S cluster per subunit.","4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2)","3D-structure; 3Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["LEUC_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster per subunit (By similarity).","3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)","4Fe-4S; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Leucine biosynthesis; Lyase; Metal-binding; Reference proteome"]
["LIPA_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase"]
["MBHS_ECOLI",0.76695393168643,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 3Fe-4S cluster (By similarity).; Binds 2 4Fe-4S clusters (By similarity).","Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase)","3D-structure; 3Fe-4S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Signal; Transmembrane; Transmembrane helix"]
["MBHT_ECOLI",0.76695393168643,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 3Fe-4S cluster (By similarity).; Binds 2 4Fe-4S clusters (By similarity).","Hydrogenase-2 small chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 small subunit) (NiFe hydrogenase)","3Fe-4S; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Periplasm; Reference proteome; Signal"]
["MIAB_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Probable).","(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB (EC 2.-.-.-) (tRNA-i(6)A37 methylthiotransferase)","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing"]
["MOAA_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate (By similarity).; Binds 1 S-adenosyl-L-methionine per subunit (By similarity).","Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A)","4Fe-4S; Complete proteome; Direct protein sequencing; GTP-binding; Iron; Iron-sulfur; Lyase; Metal-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding; Reference proteome; S-adenosyl-L-methionine"]
["MUG_ECOLI",0.692867354708549,"FP","Uniprot",null,"No annotation","G/U mismatch-specific DNA glycosylase (EC 3.2.2.28) (Double-strand-specific uracil glycosylase) (Mismatch-specific uracil DNA-glycosylase) (MUG)","3D-structure; Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding; Glycosidase; Hydrolase; Reference proteome"]
["MUTY_ECOLI",0.713087017924912,"TP","Fontecave et al, 2008","Nucleic acid-binding proteins","Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.","A/G-specific adenine glycosylase (EC 3.2.2.-)","3D-structure; 4Fe-4S; Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["NADA_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster per subunit.","Quinolinate synthase A (EC 2.5.1.72)","4Fe-4S; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Iron; Iron-sulfur; Metal-binding; Pyridine nucleotide biosynthesis; Redox-active center; Reference proteome; Transferase"]
["NAPA_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster (By similarity).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Periplasmic nitrate reductase (EC 1.7.99.4)","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Periplasm; Reference proteome; Signal; Transport"]
["NAPF_ECOLI",0.951435219977823,"TP","Fontecave et al, 2008","Electron transfert","No annotation","Ferredoxin-type protein NapF","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["NAPG_ECOLI",0.986109579232755,"TP","Fontecave et al, 2008","Electron transfert","No annotation","Ferredoxin-type protein NapG","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Signal; Transport"]
["NAPH_ECOLI",0.951435219977823,"TP","Fontecave et al, 2008","Electron transfert","No annotation","Ferredoxin-type protein NapH","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["NARG_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster per subunit.; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","Respiratory nitrate reductase 1 alpha chain (EC 1.7.99.4) (Nitrate reductase A subunit alpha) (Quinol-nitrate oxidoreductase subunit alpha)","3D-structure; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Reference proteome; Transport"]
["NARH_ECOLI",0.909468000076916,"TP","Fontecave et al, 2008","Electron transfert","Binds 3 4Fe-4S clusters per subunit.; Binds 1 3Fe-4S cluster per subunit.","Respiratory nitrate reductase 1 beta chain (EC 1.7.99.4) (Nitrate reductase A subunit beta) (Quinol-nitrate oxidoreductase subunit beta)","3D-structure; 3Fe-4S; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Nitrate assimilation; Oxidoreductase; Reference proteome; Repeat; Transport"]
["NARY_ECOLI",0.914870878718067,"TP","Fontecave et al, 2008","Electron transfert","Binds 3 4Fe-4S clusters per subunit (By similarity).; Binds 1 3Fe-4S cluster per subunit (By similarity).","Respiratory nitrate reductase 2 beta chain (EC 1.7.99.4)","3Fe-4S; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Nitrate assimilation; Oxidoreductase; Reference proteome; Repeat; Transport"]
["NARZ_ECOLI",0.92482285767648,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster per subunit (By similarity).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Respiratory nitrate reductase 2 alpha chain (EC 1.7.99.4)","4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Reference proteome; Transport"]
["NFUA_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","Binds 1 4Fe-4S cluster per subunit. The cluster is presumably bound at the interface of two monomers.","Fe/S biogenesis protein NfuA","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Stress response"]
["NIFJ_ECOLI",0.943433672456152,"TP","Uniprot",null,"No annotation","Probable pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat; Transport"]
["NIFU_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","No annotation","NifU-like protein","3D-structure; Complete proteome; Reference proteome"]
["NIRB_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Binds 1 siroheme per subunit.; Binds 1 4Fe-4S cluster per subunit.; FAD.","Nitrite reductase (NADH) large subunit (EC 1.7.1.15)","4Fe-4S; Complete proteome; FAD; Flavoprotein; Heme; Iron; Iron-sulfur; Metal-binding; NAD; Nitrate assimilation; Oxidoreductase; Reference proteome"]
["NIRD_ECOLI",0.82866245720806,"FP","Uniprot",null,"No annotation","Nitrite reductase (NADH) small subunit (EC 1.7.1.15)","3D-structure; Complete proteome; Cytoplasm; NAD; Nitrate assimilation; Oxidoreductase; Reference proteome"]
["NPD_ECOLI",0.596937535802293,"FP","Uniprot",null,"Binds 1 zinc ion per subunit.","NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog)","3D-structure; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; NAD; Reference proteome; Zinc"]
["NRDG_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","Anaerobic ribonucleoside-triphosphate reductase-activating protein (EC 1.97.1.-) (Class III anaerobic ribonucleotide reductase small component)","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["NRFC_ECOLI",0.999446266235018,"TP","Fontecave et al, 2008","Electron transfert","No annotation","Protein NrfC","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat; Signal; Transport"]
["NSR_ECOLI*","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","Binds 1 4Fe-4S cluster per subunit (Probable).","Regulatory protein YeiL","4Fe-4S; Activator; Complete proteome; Cytoplasm; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation"]
["NSRR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","Binds 1 2Fe-2S cluster per subunit (Potential).","HTH-type transcriptional repressor NsrR","2Fe-2S; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation"]
["NUOB_ECOLI",0.76695393168643,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 4Fe-4S cluster (By similarity).","NADH-quinone oxidoreductase subunit B (EC 1.6.99.5) (NADH dehydrogenase I subunit B) (NDH-1 subunit B) (NUO2)","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Transport; Ubiquinone"]
["NUOE_ECOLI",0.95489596087534,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster (Potential).","NADH-quinone oxidoreductase subunit E (EC 1.6.99.5) (NADH dehydrogenase I subunit E) (NDH-1 subunit E) (NUO5)","2Fe-2S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubiquinone"]
["NUOF_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Binds 1 FMN (Potential).; Binds 1 4Fe-4S cluster (Potential).","NADH-quinone oxidoreductase subunit F (EC 1.6.99.5) (NADH dehydrogenase I subunit F) (NDH-1 subunit F) (NUO6)","4Fe-4S; Complete proteome; Direct protein sequencing; FMN; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubiquinone"]
["NUOG_ECOLI",0.999918931872816,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster per subunit (By similarity).; Binds 3 4Fe-4S clusters per subunit (By similarity).","NADH-quinone oxidoreductase subunit G (EC 1.6.99.5) (NADH dehydrogenase I subunit G) (NDH-1 subunit G) (NUO7)","2Fe-2S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubiquinone"]
["NUOI_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","Binds 2 4Fe-4S clusters per subunit (By similarity).","NADH-quinone oxidoreductase subunit I (EC 1.6.99.5) (NADH dehydrogenase I subunit I) (NDH-1 subunit I) (NUO9)","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Repeat; Ubiquinone"]
["PAAE_ECOLI",0.946083532986615,"TP","Uniprot",null,"Binds 1 2Fe-2S cluster.; FAD.","1,2-phenylacetyl-CoA epoxidase, subunit E (EC 1.-.-.-) (1,2-phenylacetyl-CoA epoxidase, reductase subunit) (1,2-phenylacetyl-CoA monooxygenase, subunit E)","2Fe-2S; Complete proteome; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transport"]
["PFLA_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 1) (PFL-activating enzyme 1)","3D-structure; 4Fe-4S; Carbohydrate metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Glucose metabolism; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["PFLC_ECOLI",0.984091779573383,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","Pyruvate formate-lyase 2-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 2) (PFL-activating enzyme 2)","4Fe-4S; Carbohydrate metabolism; Complete proteome; Cytoplasm; Glucose metabolism; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["PFLE_ECOLI",0.98775926295133,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","Putative pyruvate formate-lyase 3-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 3) (PFL-activating enzyme 3)","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["PHNJ_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster per subunit.; S-adenosyl-L-methionine.","Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase (PRPn C-P lyase) (EC 4.7.1.1)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["PRET_ECOLI*",0.612057372580482,"FP","Uniprot",null,"No annotation","NAD-dependent dihydropyrimidine dehydrogenase subunit PreT (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)","Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome"]
["PRPD_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 2Fe-2S cluster.","2-methylcitrate dehydratase (EC 4.2.1.79)","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["RIMO_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","Ribosomal protein S12 methylthiotransferase RimO (S12 MTTase) (S12 methylthiotransferase) (EC 2.-.-.-) (Ribosome maturation factor RimO)","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase"]
["RLMC_ECOLI","<0.5","FN","Uniprot",null,"No annotation","23S rRNA (uracil(747)-C(5))-methyltransferase RlmC (EC 2.1.1.189) (23S rRNA(m5U747)-methyltransferase)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; rRNA processing"]
["RLMN_ECOLI",0.79200998411813,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.-) (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase)","3D-structure; 4Fe-4S; Antibiotic resistance; Complete proteome; Cytoplasm; Disulfide bond; Iron; Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; rRNA processing; tRNA processing"]
["RNFB_ECOLI",0.975879907785533,"TP","Fontecave et al, 2008","Electron transfert","Binds 1 2Fe-2S cluster (Potential).; Binds 2 4Fe-4S clusters (Potential).","Electron transport complex protein RnfB","2Fe-2S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transport"]
["RNFC_ECOLI",0.953414218130551,"TP","Fontecave et al, 2008","Electron transfert","Binds 2 4Fe-4S clusters per subunit (Potential).","Electron transport complex protein RnfC","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transport"]
["RUMA_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","No annotation","23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD (EC 2.1.1.190) (23S rRNA(m5U1939)-methyltransferase)","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; rRNA processing"]
["SDHL_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster (Probable).","L-serine dehydratase 1 (SDH 1) (EC 4.3.1.17) (L-serine deaminase 1) (L-SD1)","4Fe-4S; Complete proteome; Direct protein sequencing; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["SDHM_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster (Probable).","L-serine dehydratase 2 (SDH 2) (EC 4.3.1.17) (L-serine deaminase 2) (L-SD2)","4Fe-4S; Complete proteome; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["SOXR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","No annotation","Redox-sensitive transcriptional activator SoxR","2Fe-2S; 3D-structure; Activator; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transcription; Transcription regulation"]
["SUFA_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","No annotation","Protein SufA","3D-structure; Complete proteome; Reference proteome"]
["SUFB_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","No annotation","FeS cluster assembly protein SufB","Complete proteome; Reference proteome"]
["TDCG_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Binds 1 4Fe-4S cluster (Probable).","L-serine dehydratase TdcG (SDH) (EC 4.3.1.17) (L-serine deaminase)","4Fe-4S; Complete proteome; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["THIC_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Thiamine biosynthesis; Zinc"]
["THIH_ECOLI",0.79200998411813,"TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Binds 1 4Fe-4S cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","2-iminoacetate synthase (EC 4.1.99.19) (Dehydroglycine synthase) (Tyrosine lyase)","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Thiamine biosynthesis"]
["TORA_ECOLI",0.842933122896432,"FP","Uniprot",null,"Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Trimethylamine-N-oxide reductase 1 (TMAO reductase 1) (Trimethylamine oxidase 1) (EC 1.7.2.3)","Complete proteome; Direct protein sequencing; Metal-binding; Molybdenum; Oxidoreductase; Periplasm; Reference proteome; Signal"]
["TORZ_ECOLI",0.842933122896432,"FP","Uniprot",null,"Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Trimethylamine-N-oxide reductase 2 (TMAO reductase 2) (Trimethylamine oxidase 2) (EC 1.7.2.3)","Complete proteome; Direct protein sequencing; Metal-binding; Molybdenum; Oxidoreductase; Periplasm; Reference proteome; Signal"]
["TTDA_ECOLI","<0.5","FN","Uniprot",null,"Iron-sulfur.","L(+)-tartrate dehydratase subunit alpha (L-TTD alpha) (EC 4.2.1.32)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["XDHC_ECOLI",0.937711315046315,"TP","Fontecave et al, 2008","Electron transfert","Binds 2 2Fe-2S clusters (By similarity).","Xanthine dehydrogenase iron-sulfur-binding subunit","2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Purine metabolism; Purine salvage; Reference proteome"]
["XDHD_ECOLI",0.795496792974751,"TP","Uniprot",null,"Binds 2 2Fe-2S centers (Potential).; Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit (By similarity).","Probable hypoxanthine oxidase XdhD (EC 1.-.-.-)","2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase; Purine metabolism; Purine salvage; Reference proteome"]
["YAGT_ECOLI",0.94384651119302,"TP","Uniprot",null,"No annotation","Putative xanthine dehydrogenase YagT iron-sulfur-binding subunit","2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Purine metabolism; Purine salvage; Reference proteome; Signal"]
["YBHJ_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster per subunit (By similarity).","Uncharacterized protein YbhJ","Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["YCBX_ECOLI",0.933923513143907,"FP","Uniprot",null,"No annotation","Uncharacterized protein YcbX","Complete proteome; Reference proteome"]
["YCCM_ECOLI",0.951435219977823,"TP","Uniprot",null,"No annotation","Putative electron transport protein YccM","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["YDEM_ECOLI",0.79200998411813,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).; May bind at least one other iron-sulfur cluster (Potential).","Anaerobic sulfatase-maturating enzyme homolog YdeM (AnSME homolog)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["YDEP_ECOLI",0.842933122896432,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Protein YdeP","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome"]
["YDHV_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster per subunit (By similarity).; Binds 1 molybdenum-molybdopterin or 1 tungstopterin cofactor per subunit (By similarity).","Uncharacterized oxidoreductase YdhV (EC 1.-.-.-)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["YDHX_ECOLI",0.975879907785533,"TP","Uniprot",null,"No annotation","Uncharacterized ferredoxin-like protein YdhX","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Signal"]
["YDHY_ECOLI",0.999223707815756,"TP","Uniprot",null,"No annotation","Uncharacterized ferredoxin-like protein YdhY","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat"]
["YDIJ_ECOLI",0.835150180304912,"FP","Uniprot",null,"No annotation","Uncharacterized protein YdiJ","Complete proteome; Reference proteome"]
["YDIT_ECOLI",0.961614515827717,"TP","Uniprot",null,"No annotation","Ferredoxin-like protein YdiT","Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["YEAW_ECOLI",0.93798742857773,"TP","Uniprot",null,"Binds 1 2Fe-2S cluster (Probable).; Binds 1 iron ion (Probable).","Putative dioxygenase subunit alpha YeaW (EC 1.14.-.-)","2Fe-2S; Complete proteome; Dioxygenase; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome"]
["YEAX_ECOLI",0.946083532986615,"TP","Uniprot",null,"FMN (By similarity).","Putative dioxygenase subunit beta YeaX (EC 1.-.-.-)","2Fe-2S; Complete proteome; Electron transport; FMN; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transport"]
["YEIA_ECOLI",0.951435219977823,"TP","Uniprot",null,"Binds 2 4Fe-4S clusters (Potential).","NAD-dependent dihydropyrimidine dehydrogenase subunit PreA (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Repeat"]
["YFAE_ECOLI",0.946083532986615,"TP","Uniprot",null,"Binds 1 2Fe-2S cluster (Potential).","Uncharacterized ferredoxin-like protein YfaE","2Fe-2S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["YFHL_ECOLI",0.951435219977823,"TP","Uniprot",null,"No annotation","Uncharacterized ferredoxin-like protein YfhL","3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat"]
["YGCF_ECOLI*",0.79200998411813,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).; Binds 1 S-adenosyl-L-methionine per subunit (By similarity).","7-carboxy-7-deazaguanine synthase (CDG synthase) (EC 4.3.99.3) (Queuosine biosynthesis protein QueE)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Queuosine biosynthesis; Reference proteome; S-adenosyl-L-methionine"]
["YGCO_ECOLI",0.974240056046706,"TP","Uniprot",null,"No annotation","Ferredoxin-like protein YgcO","Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["YGFK_ECOLI",0.989248668709625,"TP","Uniprot",null,"No annotation","Uncharacterized protein YgfK","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["YGFS_ECOLI",0.975879907785533,"TP","Uniprot",null,"No annotation","Putative electron transport protein YgfS","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["YGFT_ECOLI",0.975879907785533,"TP","Uniprot",null,"Binds 4 4Fe-4S clusters (By similarity). May potentially bind 2 additional iron-sulfur clusters.","Uncharacterized protein YgfT","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat"]
["YGGW_ECOLI",0.79200998411813,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).","Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW (EC 1.3.99.-)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; Reference proteome; S-adenosyl-L-methionine"]
["YGIQ_ECOLI",0.79200998411813,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).","UPF0313 protein YgiQ","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["YHCC_ECOLI",0.79200998411813,"FP","Uniprot",null,"No annotation","Uncharacterized protein YhcC","Complete proteome; Reference proteome"]
["YJEK_ECOLI*",0.79200998411813,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; Pyridoxal phosphate.","L-lysine 2,3-aminomutase (LAM) (EC 5.4.3.-) (EF-P post-translational modification enzyme B)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Isomerase; Metal-binding; Pyridoxal phosphate; Reference proteome; S-adenosyl-L-methionine"]
["YJES_ECOLI*",0.925431814773998,"TP","Uniprot",null,"No annotation","Epoxyqueuosine reductase (EC 1.1.-.-) (Queuosine biosynthesis protein QueG)","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Queuosine biosynthesis; Reference proteome; tRNA processing"]
["YJIL_ECOLI","<0.5","FN","Uniprot",null,"Binds 1 4Fe-4S cluster per dimer (Potential).","Uncharacterized protein YjiL","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["YJJW_ECOLI",0.99580846880132,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).; Binds 2 4Fe-4S clusters (Potential).","Uncharacterized protein YjjW","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; S-adenosyl-L-methionine"]
["YKGF_ECOLI",0.953414218130551,"TP","Uniprot",null,"No annotation","Uncharacterized electron transport protein YkgF","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["YNFE_ECOLI",0.92482285767648,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Putative dimethyl sulfoxide reductase chain YnfE (DMSO reductase) (EC 1.8.99.-)","4Fe-4S; Cell membrane; Complete proteome; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome; Signal"]
["YNFF_ECOLI",0.92482285767648,"TP","Uniprot",null,"Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Probable dimethyl sulfoxide reductase chain YnfF (DMSO reductase) (EC 1.8.99.-)","4Fe-4S; Cell membrane; Complete proteome; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome; Signal"]
["YNFG_ECOLI",0.975879907785533,"TP","Uniprot",null,"Binds 4 4Fe-4S clusters (By similarity).","Probable anaerobic dimethyl sulfoxide reductase chain YnfG (DMSO reductase iron-sulfur subunit YnfG)","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["YSAA_ECOLI",0.975879907785533,"TP","Uniprot",null,"No annotation","Putative electron transport protein YsaA","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
[]
[]
["*: YJEK_ECOLI = EPMB_ECOLI",null,null,null," "]
["*: YGCF_ECOLI = QUEE_ECOLI"]
["*: YJES_ECOLI = QUEG_ECOLI"]
["*: PRET_ECOLI = YEIT_ECOLI"]
["*: NSR_ECOLI = YEIL_ECOLI"]
["NB: all the proteins have a reviewed status in SwissProt"]

{"sheet":"Supplementary_Table_5","index":5,"n_rows":48,"n_cols":4,"rows_kept":48,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Identifier","Weight","Descriptor Source","Description"]
["SSF102114",1.36809164,"Superfamily","Radical SAM enzymes superfamily"]
["SSF46548",1.05003999,"Superfamily","alpha-helical ferredoxin superfamily"]
["SSF54292",0.56159254,"Superfamily","2Fe-2S ferredoxin-like superfamily"]
["SSF50022",0.54637503,"Superfamily","ISP domain superfamily"]
["SSF54862",0.52641888,"Superfamily","4Fe-4S ferredoxins superfamily"]
["PS51296",0.5614066,"Prosite","Rieske [2Fe-2S] iron-sulfur domain profile"]
["PS51085",0.56138004,"Prosite","2Fe-2S ferredoxin-type iron-sulfur binding domain profile"]
["PS51379",0.41190272,"Prosite","4Fe-4S ferredoxin-type iron-sulfur binding domain profile"]
["PS00197",0.1102124,"Prosite","2Fe-2S ferredoxin-type iron-sulfur binding region signature"]
["PF10576",2.22971722,"Pfam","Iron-sulfur binding domain of endonuclease III"]
["PF04055",1.28828501,"Pfam","Radical SAM superfamily"]
["PF04879",0.82953905,"Pfam","Molybdopterin oxidoreductase Fe4S4 domain"]
["PF00111",0.62763107,"Pfam","2Fe-2S iron-sulfur cluster binding domain"]
["PF00355",0.57881546,"Pfam","Rieske [2Fe-2S] domain"]
["PF00037",0.06745733,"Pfam","4Fe-4S binding domain"]
["Q3ABV6",2.51048332,"HHpred","[Ni/Fe] hydrogenase, small subunit"]
["Q8RBD2",2.22272763,"HHpred","NADH:ubiquinone oxidoreductase 24 kD subunit"]
["O66511",2.1491957,"HHpred","Ferredoxin, 2Fe-2S (AaFd4)"]
["P00260",2.13287808,"HHpred","High-potential iron-sulfur protein (HiPIP)"]
["Q5SJ65",2.13285159,"HHpred","Uracil-DNA glycosylase superfamily"]
["P27988",1.82811388,"HHpred","Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha (ACS subunit) (Acetyl-CoA synthase subunit) (CODH/ACS) (EC 2.3.1.169)"]
["A7GH10",1.82811157,"HHpred","Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP)"]
["Q72LA4",1.71201367,"HHpred","Thiosulfate reductase (EC 1.-.-.-)"]
["Q5NZV2",1.28749501,"HHpred","Ethylbenzene dehydrogenase, alpha subunit"]
["Q16134",0.72522131,"HHpred","Electron transfer flavoprotein-ubiquinone oxidoreductase"]
["P17596",0.60045926,"HHpred","Fumarate reductase iron-sulfur subunit (EC 1.3.99.1)"]
["P07839",0.44526932,"HHpred","Ferredoxin"]
["E5ANV0",0.44302301,"HHpred","Ferredoxin"]
["Q2W8G1",0.44292131,"HHpred","Ferredoxin"]
["C0QF67",0.44292021,"HHpred","Iron-sulfur cluster binding protein"]
["A4J273",0.44277574,"HHpred","Dissimilatory adenylylsulfate reductase beta subunit (EC 1.8.99.2)"]
["C4QZA1",0.4283203,"HHpred","Adrenodoxin homolog"]
["A4XDY3",0.39267244,"HHpred","Ring hydroxylating dioxygenase, alpha subunit"]
["O82822",0.39260623,"HHpred","Ferredoxin"]
["B2DD11",0.39247009,"HHpred","Terminal oxygenase component of carbazole 1,9a-dioxygenase"]
["Q00458",0.39228393,"HHpred","Toluene-4-monooxygenase system ferredoxin subunit (Toluene-4-monooxygenase system protein C) (T4moC)"]
["C4FIX5",0.39190874,"HHpred","Arsenite oxidase, small subunit (EC 1.20.98.1)"]
["P0C8N8",0.38715363,"HHpred","Cytochrome b6-f complex iron-sulfur subunit (EC 1.10.9.1) (Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein) (ISP) (RISP) (Rieske iron-sulfur protein)"]
["D5BBI0",0.30691756,"HHpred","PaaE-like NADH oxidoreductase"]
["Q46509",0.21631334,"HHpred","Aldehyde oxidoreductase (EC 1.2.99.7) (Molybdenum iron sulfur protein)"]
["Q72LA5",0.16770903,"HHpred","NrfC protein"]
["P07771",0.16426808,"HHpred","Benzoate 1,2-dioxygenase electron transfer component [Includes: Ferredoxin; Ferredoxin--NAD(+) reductase (EC 1.18.1.3)]"]
["P46374",0.15127018,"HHpred","Ferredoxin fas2"]
["Q05182",0.11880356,"HHpred","Phthalate 4,5-dioxygenase oxygenase reductase subunit (EC 1.14.12.7)"]
["Q01GW4",0.08734394,"HHpred","DNAJ heat shock N-terminal domain-containing protein (ISS) (Fragment)"]
["B0CC75",0.07361691,"HHpred","Ferredoxin, 4Fe-4S type, putative"]
["D6S8U2",0.04302018,"HHpred","2Fe-2S iron-sulfur cluster binding domain protein"]

{"sheet":"Supplementary_Table_6","index":6,"n_rows":159,"n_cols":9,"rows_kept":159,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Accession number","Entry name (UniProtKB)","InFeS Score\nExtended Model","Status","FeS annotation source ","Functional class\n(according to Fontecave et al., 2008)","Protein names","General annotation (cofactor)","Keywords"]
["P25516","ACON1_ECOLI","0.879269","TP","Fontecave et al, 2008","Non redox catalysis","Aconitate hydratase 1 (Aconitase 1) (EC 4.2.1.3) (Citrate hydro-lyase 1)","Binds 1 4Fe-4S cluster per subunit (By similarity).","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["P36683","ACON2_ECOLI","0.879269","TP","Fontecave et al, 2008","Non redox catalysis","Aconitate hydratase 2 (Aconitase) (EC 4.2.1.3) (2-methylisocitrate dehydratase) (EC 4.2.1.99) (Citrate hydro-lyase)","Binds 1 4Fe-4S cluster per subunit.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["P37127","AEGA_ECOLI","0.996297","TP","Uniprot",null,"Protein AegA","Binds 4 4Fe-4S clusters (By similarity).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat"]
["P35340","AHPF_ECOLI","0.739959","FP","Uniprot",null,"Alkyl hydroperoxide reductase subunit F (EC 1.8.1.-) (Alkyl hydroperoxide reductase F52A protein)","Binds 1 FAD per subunit (By similarity).","3D-structure; Acetylation; Complete proteome; Disulfide bond; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Redox-active center; Reference proteome"]
["P25550","ASLB_ECOLI","0.934953","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Anaerobic sulfatase-maturating enzyme homolog AslB (AnSME homolog)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).; May bind at least one other iron-sulfur cluster (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["P0AE56","BFD_ECOLI","0.770116","TP","Fontecave et al, 2008","Electron transfert","Bacterioferritin-associated ferredoxin","Binds 1 2Fe-2S cluster.","2Fe-2S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["P12996","BIOB_ECOLI","0.964241","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Biotin synthase (EC 2.8.1.6)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; Binds 1 2Fe-2S cluster. The cluster is coordinated with 3 cysteines and 1 arginine.","2Fe-2S; 3D-structure; 4Fe-4S; Biotin biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase"]
["P20099","BISC_ECOLI","0.920781","FP","Uniprot",null,"Biotin sulfoxide reductase (BDS reductase) (BSO reductase) (EC 1.-.-.-) (L-methionine-(S)-sulfoxide reductase) (Met-S-SO reductase) (EC 1.8.4.13)","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (Probable).","Complete proteome; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome"]
["P17846","CYSI_ECOLI","0.754316","TP","Fontecave et al, 2008","Electron transfert","Sulfite reductase [NADPH] hemoprotein beta-component (SiR-HP) (SiRHP) (EC 1.8.1.2)","Binds 1 siroheme per subunit.; Binds 1 4Fe-4S cluster per subunit.","3D-structure; 4Fe-4S; Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Direct protein sequencing; Heme; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["P07014","DHSB_ECOLI","0.998669","TP","Fontecave et al, 2008","Electron transfert","Succinate dehydrogenase iron-sulfur subunit (EC 1.3.99.1)","Binds 1 2Fe-2S cluster.; Binds 1 3Fe-4S cluster.; Binds 1 4Fe-4S cluster.","2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Transport; Tricarboxylic acid cycle"]
["P27296","DING_ECOLI","<0.5","FN","Ren et al, 2008","Nucleic acid-binding proteins","Probable ATP-dependent helicase DinG (EC 3.6.4.12) (DNA-damage-inducible protein G)","Binds 1 4Fe-4S cluster.","4Fe-4S; ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Reference proteome"]
["P18775","DMSA_ECOLI","0.904143","TP","Fontecave et al, 2008","Electron transfert","Dimethyl sulfoxide reductase DmsA (DMSO reductase) (DMSOR) (Me2SO reductase) (EC 1.8.5.3)","Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome; Signal"]
["P18776","DMSB_ECOLI","0.984128","TP","Fontecave et al, 2008","Electron transfert","Anaerobic dimethyl sulfoxide reductase chain B (DMSO reductase iron-sulfur subunit)","Binds 4 4Fe-4S clusters.","4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P0AB83","END3_ECOLI","0.883615","TP","Fontecave et al, 2008","Nucleic acid-binding proteins","Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase)","Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in DNA-binding and proper positioning of the enzyme along the DNA strand.","3D-structure; 4Fe-4S; Complete proteome; DNA damage; DNA repair; DNA-binding; Direct protein sequencing; Glycosidase; Hydrolase; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P0ACC3","ERPA_ECOLI","0.944284","TP","Fontecave et al, 2008","Metallosite assembly","Iron-sulfur cluster insertion protein ErpA","Binds 1 iron-sulfur cluster per subunit. A study found 40-50% as 2Fe-2S clusters, 15-25% as 4Fe-4S clusters and the rest as paramagnetic iron.","Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["P42593","FADH_ECOLI","0.759676","TP","Fontecave et al, 2008","Electron transfert","2,4-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34) (2,4-dienoyl coenzyme A reductase)","FAD.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["P32177","FDHD_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Protein FdhD","No annotation","Complete proteome; Cytoplasm; Reference proteome"]
["P07658","FDHF_ECOLI","0.954335","TP","Fontecave et al, 2008","Electron transfert","Formate dehydrogenase H (EC 1.1.99.33) (EC 1.2.1.2) (Formate dehydrogenase-H subunit alpha) (FDH-H) (Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide)","Binds 1 4Fe-4S cluster per subunit.; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Reference proteome; Selenocysteine"]
["P24183","FDNG_ECOLI","0.954335","TP","Fontecave et al, 2008","Electron transfert","Formate dehydrogenase, nitrate-inducible, major subunit (EC 1.2.1.2) (Anaerobic formate dehydrogenase major subunit) (Formate dehydrogenase-N subunit alpha) (FDH-N subunit alpha)","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.; Binds 1 4Fe-4S cluster per subunit.","3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Periplasm; Reference proteome; Selenocysteine; Signal"]
["P0AAJ3","FDNH_ECOLI","0.984128","TP","Fontecave et al, 2008","Electron transfert","Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (Anaerobic formate dehydrogenase iron-sulfur subunit) (Formate dehydrogenase-N subunit beta) (FDH-N subunit beta)","Binds 4 4Fe-4S clusters per subunit.","3D-structure; 4Fe-4S; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["P32176","FDOG_ECOLI","0.954335","TP","Fontecave et al, 2008","Electron transfert","Formate dehydrogenase-O major subunit (EC 1.2.1.2) (Aerobic formate dehydrogenase major subunit) (FDH-Z subunit alpha) (Formate dehydrogenase-O subunit alpha)","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).; Binds 1 4Fe-4S cluster (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; NAD; Oxidoreductase; Periplasm; Reference proteome; Selenocysteine; Signal"]
["P0AAJ5","FDOH_ECOLI","0.984128","TP","Fontecave et al, 2008","Electron transfert","Formate dehydrogenase-O iron-sulfur subunit (Aerobic formate dehydrogenase iron-sulfur subunit) (FDH-Z subunit beta) (Formate dehydrogenase-O subunit beta)","Binds 4 4Fe-4S clusters per subunit (By similarity).","4Fe-4S; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["P0A9R4","FER_ECOLI","0.953463","TP","Fontecave et al, 2008","Electron transfert","2Fe-2S ferredoxin","Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["P39405","FHUF_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Ferric iron reductase protein FhuF","Binds 1 2Fe-2S cluster.","2Fe-2S; Cell membrane; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome"]
["P68646","FIXX_ECOLI","0.803568","TP","Uniprot",null,"Ferredoxin-like protein FixX","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["P0A9E5","FNR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","Fumarate and nitrate reduction regulatory protein","Binds 1 4Fe-4S cluster per subunit.","4Fe-4S; Activator; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation"]
["P0AC47","FRDB_ECOLI","0.999147","TP","Fontecave et al, 2008","Electron transfert","Fumarate reductase iron-sulfur subunit (EC 1.3.99.1)","Binds 1 2Fe-2S cluster.; Binds 1 3Fe-4S cluster.; Binds 1 4Fe-4S cluster.","2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Transport; Tricarboxylic acid cycle"]
["P0AC33","FUMA_ECOLI","0.791504","TP","Fontecave et al, 2008","Non redox catalysis","Fumarate hydratase class I, aerobic (Fumarase) (EC 4.2.1.2)","Binds 1 4Fe-4S cluster.","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["P14407","FUMB_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Fumarate hydratase class I, anaerobic (Fumarase) (EC 4.2.1.2)","Binds 1 4Fe-4S cluster.","4Fe-4S; Acetylation; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; Tricarboxylic acid cycle"]
["P52074","GLCF_ECOLI","0.988474","TP","Uniprot",null,"Glycolate oxidase iron-sulfur subunit","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P0A9C0","GLPA_ECOLI","0.770116","FP","Uniprot",null,"Anaerobic glycerol-3-phosphate dehydrogenase subunit A (G-3-P dehydrogenase) (EC 1.1.5.3)","FAD.; FMN.","Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Membrane; Oxidoreductase; Reference proteome"]
["P13033","GLPB_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Anaerobic glycerol-3-phosphate dehydrogenase subunit B (Anaerobic G-3-P dehydrogenase subunit B) (Anaerobic G3Pdhase B) (EC 1.1.5.3)","FMN","Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; FMN; Flavoprotein; Membrane; Oxidoreductase; Reference proteome"]
["P0A996","GLPC_ECOLI","0.983437","TP","Uniprot",null,"Anaerobic glycerol-3-phosphate dehydrogenase subunit C (G-3-P dehydrogenase)","No annotation","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transport"]
["P0AC69","GLRX4_ECOLI","<0.5","FN","Uniprot",null,"Glutaredoxin-4 (Grx4) (Monothiol glutaredoxin)","No annotation","2Fe-2S; 3D-structure; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Redox-active center; Reference proteome"]
["P09831","GLTB_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Glutamate synthase [NADPH] large chain (EC 1.4.1.13) (Glutamate synthase subunit alpha) (GLTS alpha chain) (NADPH-GOGAT)","Binds 1 3Fe-4S cluster.; FAD.; FMN.","3Fe-4S; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; FAD; FMN; Flavoprotein; Glutamate biosynthesis; Glutamine amidotransferase; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome; Zymogen"]
["P09832","GLTD_ECOLI","0.929065","TP","Fontecave et al, 2008","Electron transfert","Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (NADPH-GOGAT)","Binds 1 4Fe-4S cluster.","4Fe-4S; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; Glutamate biosynthesis; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["P0ABW0","HCAC_ECOLI","0.931131","TP","Fontecave et al, 2008","Electron transfert","3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit (Digoxigenin ferredoxin subunit)","No annotation","2Fe-2S; Aromatic hydrocarbons catabolism; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["P0ABR5","HCAE_ECOLI","0.955274","TP","Uniprot",null,"3-phenylpropionate/cinnamic acid dioxygenase subunit alpha (EC 1.14.12.19) (Digoxigenin subunit alpha)","Binds 1 2Fe-2S cluster (Probable).; Binds 1 iron ion (Probable).","2Fe-2S; Aromatic hydrocarbons catabolism; Complete proteome; Dioxygenase; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome"]
["P75825","HCP_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP)","Binds 1 2Fe-2S cluster.; Binds 1 hybrid 4Fe-2O-2S cluster.","2Fe-2S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["P75824","HCR_ECOLI","0.96527","TP","Fontecave et al, 2008","Electron transfert","NADH oxidoreductase hcr (EC 1.-.-.-)","Binds 1 2Fe-2S cluster.; FAD.","2Fe-2S; Complete proteome; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transport"]
["P32131","HEMN_ECOLI","0.931135","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Oxygen-independent coproporphyrinogen-III oxidase (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.99.22)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","3D-structure; 4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; Reference proteome; S-adenosyl-L-methionine"]
["P0AAJ8","HYBA_ECOLI","0.999159","TP","Fontecave et al, 2008","Electron transfert","Hydrogenase-2 operon protein HybA","Binds 4 4Fe-4S clusters (By similarity).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Periplasm; Reference proteome; Repeat; Signal"]
["P0AAK1","HYCB_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","Formate hydrogenlyase subunit 2 (FHL subunit 2) (Hydrogenase-3 component B)","Binds 4 4Fe-4S clusters (By similarity).","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P16431","HYCE_ECOLI","<0.5","FN","Uniprot",null,"Formate hydrogenlyase subunit 5 (FHL subunit 5) (Hydrogenase-3 component E)","Binds 1 4Fe-4S cluster (Potential).; Nickel (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; NAD; Nickel; Oxidoreductase; Reference proteome"]
["P16432","HYCF_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","Formate hydrogenlyase subunit 6 (FHL subunit 6) (Hydrogenase-3 component F)","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P16433","HYCG_ECOLI","0.662396","TP","Fontecave et al, 2008","Electron transfert","Formate hydrogenlyase subunit 7 (FHL subunit 7) (Hydrogenase-3 component G)","Binds 1 4Fe-4S cluster (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["P0AAK4","HYDN_ECOLI","0.989267","TP","Uniprot",null,"Electron transport protein HydN","Binds 4 4Fe-4S clusters (By similarity).","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P23481","HYFA_ECOLI","0.984128","TP","Fontecave et al, 2008","Electron transfert","Hydrogenase-4 component A (EC 1.-.-.-)","Binds 4 4Fe-4S clusters (By similarity).","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat; Transport"]
["P77329","HYFG_ECOLI","<0.5","FN","Uniprot",null,"Hydrogenase-4 component G (EC 1.-.-.-)","Binds 1 4Fe-4S cluster.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome"]
["P77423","HYFH_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","Hydrogenase-4 component H","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P77668","HYFI_ECOLI","0.947304","TP","Fontecave et al, 2008","Electron transfert","Hydrogenase-4 component I (EC 1.-.-.-)","Binds 1 4Fe-4S cluster (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["P71229","HYFR_ECOLI","<0.5","FN","Fontecave et al, 2008","Electron transfert","Hydrogenase-4 transcriptional activator","No annotation","ATP-binding; Activator; Complete proteome; DNA-binding; Nucleotide-binding; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system"]
["P05791","ILVD_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9)","Binds 1 4Fe-4S cluster.","4Fe-4S; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P0AAC8","ISCA_ECOLI","0.944284","TP","Fontecave et al, 2008","Metallosite assembly","Iron-binding protein IscA (Iron-sulfur cluster assembly protein)","Binds 2 iron ions per dimer. The dimer may bind additional iron ions.","3D-structure; Complete proteome; Iron; Metal-binding; Reference proteome"]
["P0AGK8","ISCR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","HTH-type transcriptional regulator IscR","Binds 1 2Fe-2S cluster; whether or not the Fe-S cluster is necessary for transcriptional regulation depends on the type of IscR-binding sequence (PubMed:16677314).","2Fe-2S; 3D-structure; Activator; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Stress response; Transcription; Transcription regulation"]
["P62620","ISPG_ECOLI","0.621177","TP","Fontecave et al, 2008","Redox Catalysis","4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein GcpE) (Protein E)","Binds 1 4Fe-4S cluster.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis; Metal-binding; Oxidoreductase; Reference proteome"]
["P62623","ISPH_ECOLI","<0.5","FN","Fontecave et al, 2008","Redox Catalysis","4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2)","Binds 1 3Fe-4S cluster per subunit.","3D-structure; 3Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis; Metal-binding; NADP; Oxidoreductase; Reference proteome"]
["P0A6A6","LEUC_ECOLI","0.879269","TP","Fontecave et al, 2008","Non redox catalysis","3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)","Binds 1 4Fe-4S cluster per subunit (By similarity).","4Fe-4S; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Leucine biosynthesis; Lyase; Metal-binding; Reference proteome"]
["P60716","LIPA_ECOLI","0.954044","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)","Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase"]
["P69739","MBHS_ECOLI","0.947304","TP","Fontecave et al, 2008","Electron transfert","Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase)","Binds 1 3Fe-4S cluster (By similarity).; Binds 2 4Fe-4S clusters (By similarity).","3D-structure; 3Fe-4S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Signal; Transmembrane; Transmembrane helix"]
["P69741","MBHT_ECOLI","0.699027","TP","Fontecave et al, 2008","Electron transfert","Hydrogenase-2 small chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 small subunit) (NiFe hydrogenase)","Binds 1 3Fe-4S cluster (By similarity).; Binds 2 4Fe-4S clusters (By similarity).","3Fe-4S; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; Oxidoreductase; Periplasm; Reference proteome; Signal"]
["P0AEI1","MIAB_ECOLI","0.942635","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB (EC 2.-.-.-) (tRNA-i(6)A37 methylthiotransferase)","Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Probable).","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing"]
["P30745","MOAA_ECOLI","0.94471","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A)","Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate (By similarity).; Binds 1 S-adenosyl-L-methionine per subunit (By similarity).","4Fe-4S; Complete proteome; Direct protein sequencing; GTP-binding; Iron; Iron-sulfur; Lyase; Metal-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding; Reference proteome; S-adenosyl-L-methionine"]
["P0A9H1","MUG_ECOLI","0.746032","FP","Uniprot",null,"G/U mismatch-specific DNA glycosylase (EC 3.2.2.28) (Double-strand-specific uracil glycosylase) (Mismatch-specific uracil DNA-glycosylase) (MUG)","No annotation","3D-structure; Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding; Glycosidase; Hydrolase; Reference proteome"]
["P17802","MUTY_ECOLI","0.900055","TP","Fontecave et al, 2008","Nucleic acid-binding proteins","A/G-specific adenine glycosylase (EC 3.2.2.-)","Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.","3D-structure; 4Fe-4S; Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["P11458","NADA_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","Quinolinate synthase A (EC 2.5.1.72)","Binds 1 4Fe-4S cluster per subunit.","4Fe-4S; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Iron; Iron-sulfur; Metal-binding; Pyridine nucleotide biosynthesis; Redox-active center; Reference proteome; Transferase"]
["P33937","NAPA_ECOLI","0.895513","TP","Fontecave et al, 2008","Electron transfert","Periplasmic nitrate reductase (EC 1.7.99.4)","Binds 1 4Fe-4S cluster (By similarity).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Periplasm; Reference proteome; Signal; Transport"]
["P0AAL0","NAPF_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","Ferredoxin-type protein NapF","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P0AAL3","NAPG_ECOLI","0.997982","TP","Fontecave et al, 2008","Electron transfert","Ferredoxin-type protein NapG","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Signal; Transport"]
["P33934","NAPH_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","Ferredoxin-type protein NapH","No annotation","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["P09152","NARG_ECOLI","0.954335","TP","Fontecave et al, 2008","Electron transfert","Respiratory nitrate reductase 1 alpha chain (EC 1.7.99.4) (Nitrate reductase A subunit alpha) (Quinol-nitrate oxidoreductase subunit alpha)","Binds 1 4Fe-4S cluster per subunit.; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.","3D-structure; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Reference proteome; Transport"]
["P11349","NARH_ECOLI","0.975065","TP","Fontecave et al, 2008","Electron transfert","Respiratory nitrate reductase 1 beta chain (EC 1.7.99.4) (Nitrate reductase A subunit beta) (Quinol-nitrate oxidoreductase subunit beta)","Binds 3 4Fe-4S clusters per subunit.; Binds 1 3Fe-4S cluster per subunit.","3D-structure; 3Fe-4S; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Nitrate assimilation; Oxidoreductase; Reference proteome; Repeat; Transport"]
["P19318","NARY_ECOLI","0.98163","TP","Fontecave et al, 2008","Electron transfert","Respiratory nitrate reductase 2 beta chain (EC 1.7.99.4)","Binds 3 4Fe-4S clusters per subunit (By similarity).; Binds 1 3Fe-4S cluster per subunit (By similarity).","3Fe-4S; 4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Nitrate assimilation; Oxidoreductase; Reference proteome; Repeat; Transport"]
["P19319","NARZ_ECOLI","0.89543","TP","Fontecave et al, 2008","Electron transfert","Respiratory nitrate reductase 2 alpha chain (EC 1.7.99.4)","Binds 1 4Fe-4S cluster per subunit (By similarity).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","4Fe-4S; Cell membrane; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Nitrate assimilation; Oxidoreductase; Reference proteome; Transport"]
["P63020","NFUA_ECOLI","0.695862","TP","Fontecave et al, 2008","Metallosite assembly","Fe/S biogenesis protein NfuA","Binds 1 4Fe-4S cluster per subunit. The cluster is presumably bound at the interface of two monomers.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Stress response"]
["P52647","NIFJ_ECOLI","0.989267","TP","Uniprot",null,"Probable pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat; Transport"]
["P0ACD4","NIFU_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","NifU-like protein","No annotation","3D-structure; Complete proteome; Reference proteome"]
["P08201","NIRB_ECOLI","0.956611","TP","Fontecave et al, 2008","Electron transfert","Nitrite reductase (NADH) large subunit (EC 1.7.1.15)","Binds 1 siroheme per subunit.; Binds 1 4Fe-4S cluster per subunit.; FAD.","4Fe-4S; Complete proteome; FAD; Flavoprotein; Heme; Iron; Iron-sulfur; Metal-binding; NAD; Nitrate assimilation; Oxidoreductase; Reference proteome"]
["P0A9I8","NIRD_ECOLI","0.815615","FP","Uniprot",null,"Nitrite reductase (NADH) small subunit (EC 1.7.1.15)","No annotation","3D-structure; Complete proteome; Cytoplasm; NAD; Nitrate assimilation; Oxidoreductase; Reference proteome"]
["P0A9N8","NRDG_ECOLI","0.911923","TP","Fontecave et al, 2008",null,"Anaerobic ribonucleoside-triphosphate reductase-activating protein (EC 1.97.1.-) (Class III anaerobic ribonucleotide reductase small component)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["P0AAK7","NRFC_ECOLI","0.984128","TP","Fontecave et al, 2008","Electron transfert","Protein NrfC","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat; Signal; Transport"]
["P0A9E9","NSR_ECOLI*","0.538923","TP","Fontecave et al, 2008","Nucleic acid-binding proteins","Regulatory protein YeiL","Binds 1 4Fe-4S cluster per subunit (Probable).","4Fe-4S; Activator; Complete proteome; Cytoplasm; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation"]
["P0AF63","NSRR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","HTH-type transcriptional repressor NsrR","Binds 1 2Fe-2S cluster per subunit (Potential).","2Fe-2S; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation"]
["P0AFC7","NUOB_ECOLI","0.947304","TP","Fontecave et al, 2008","Electron transfert","NADH-quinone oxidoreductase subunit B (EC 1.6.99.5) (NADH dehydrogenase I subunit B) (NDH-1 subunit B) (NUO2)","Binds 1 4Fe-4S cluster (By similarity).","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Transport; Ubiquinone"]
["P0AFD1","NUOE_ECOLI","0.722753","TP","Fontecave et al, 2008","Electron transfert","NADH-quinone oxidoreductase subunit E (EC 1.6.99.5) (NADH dehydrogenase I subunit E) (NDH-1 subunit E) (NUO5)","Binds 1 2Fe-2S cluster (Potential).","2Fe-2S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubiquinone"]
["P31979","NUOF_ECOLI","0.880264","TP","Fontecave et al, 2008","Electron transfert","NADH-quinone oxidoreductase subunit F (EC 1.6.99.5) (NADH dehydrogenase I subunit F) (NDH-1 subunit F) (NUO6)","Binds 1 FMN (Potential).; Binds 1 4Fe-4S cluster (Potential).","4Fe-4S; Complete proteome; Direct protein sequencing; FMN; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubiquinone"]
["P33602","NUOG_ECOLI","0.999656","TP","Fontecave et al, 2008","Electron transfert","NADH-quinone oxidoreductase subunit G (EC 1.6.99.5) (NADH dehydrogenase I subunit G) (NDH-1 subunit G) (NUO7)","Binds 1 2Fe-2S cluster per subunit (By similarity).; Binds 3 4Fe-4S clusters per subunit (By similarity).","2Fe-2S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Ubiquinone"]
["P0AFD6","NUOI_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","NADH-quinone oxidoreductase subunit I (EC 1.6.99.5) (NADH dehydrogenase I subunit I) (NDH-1 subunit I) (NUO9)","Binds 2 4Fe-4S clusters per subunit (By similarity).","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Membrane; Metal-binding; NAD; Oxidoreductase; Quinone; Reference proteome; Repeat; Ubiquinone"]
["P76081","PAAE_ECOLI","0.943954","TP","Uniprot",null,"1,2-phenylacetyl-CoA epoxidase, subunit E (EC 1.-.-.-) (1,2-phenylacetyl-CoA epoxidase, reductase subunit) (1,2-phenylacetyl-CoA monooxygenase, subunit E)","Binds 1 2Fe-2S cluster.; FAD.","2Fe-2S; Complete proteome; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transport"]
["P0A9N4","PFLA_ECOLI","0.960986","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 1) (PFL-activating enzyme 1)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","3D-structure; 4Fe-4S; Carbohydrate metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Glucose metabolism; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["P32675","PFLC_ECOLI","0.994083","TP","Uniprot",null,"Pyruvate formate-lyase 2-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 2) (PFL-activating enzyme 2)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","4Fe-4S; Carbohydrate metabolism; Complete proteome; Cytoplasm; Glucose metabolism; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["P75794","PFLE_ECOLI","0.996731","TP","Uniprot",null,"Putative pyruvate formate-lyase 3-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 3) (PFL-activating enzyme 3)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; S-adenosyl-L-methionine"]
["P16688","PHNJ_ECOLI","<0.5","FN","Uniprot",null,"Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase (PRPn C-P lyase) (EC 4.7.1.1)","Binds 1 4Fe-4S cluster per subunit.; S-adenosyl-L-methionine.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["P25889","PREA_ECOLI","0.995304","TP","Uniprot",null,"NAD-dependent dihydropyrimidine dehydrogenase subunit PreA (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)","Binds 2 4Fe-4S clusters (Potential).","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Repeat"]
["P76440","PRET_ECOLI","0.741078","FP","Uniprot",null,"NAD-dependent dihydropyrimidine dehydrogenase subunit PreT (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)","No annotation","Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome"]
["P77243","PRPD_ECOLI","0.834374","TP","Uniprot",null,"2-methylcitrate dehydratase (EC 4.2.1.79)","Binds 1 2Fe-2S cluster.","2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P0AEI4","RIMO_ECOLI","0.942016","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","Ribosomal protein S12 methylthiotransferase RimO (S12 MTTase) (S12 methylthiotransferase) (EC 2.-.-.-) (Ribosome maturation factor RimO)","Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Transferase"]
["P75817","RLMC_ECOLI","<0.5","FN","Uniprot",null,"23S rRNA (uracil(747)-C(5))-methyltransferase RlmC (EC 2.1.1.189) (23S rRNA(m5U747)-methyltransferase)","No annotation","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; rRNA processing"]
["P36979","RLMN_ECOLI","0.956874","TP","Uniprot",null,"Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.-) (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","3D-structure; 4Fe-4S; Antibiotic resistance; Complete proteome; Cytoplasm; Disulfide bond; Iron; Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; rRNA processing; tRNA processing"]
["P77223","RNFB_ECOLI","0.989267","TP","Fontecave et al, 2008","Electron transfert","Electron transport complex protein RnfB","Binds 1 2Fe-2S cluster (Potential).; Binds 2 4Fe-4S clusters (Potential).","2Fe-2S; 4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transport"]
["P77611","RNFC_ECOLI","0.945421","TP","Fontecave et al, 2008","Electron transfert","Electron transport complex protein RnfC","Binds 2 4Fe-4S clusters per subunit (Potential).","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transport"]
["P55135","RUMA_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD (EC 2.1.1.190) (23S rRNA(m5U1939)-methyltransferase)","No annotation","3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; rRNA processing"]
["P16095","SDHL_ECOLI","0.834374","TP","Fontecave et al, 2008","Non redox catalysis","L-serine dehydratase 1 (SDH 1) (EC 4.3.1.17) (L-serine deaminase 1) (L-SD1)","Binds 1 4Fe-4S cluster (Probable).","4Fe-4S; Complete proteome; Direct protein sequencing; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P30744","SDHM_ECOLI","0.834374","TP","Fontecave et al, 2008","Non redox catalysis","L-serine dehydratase 2 (SDH 2) (EC 4.3.1.17) (L-serine deaminase 2) (L-SD2)","Binds 1 4Fe-4S cluster (Probable).","4Fe-4S; Complete proteome; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P0ACS2","SOXR_ECOLI","<0.5","FN","Fontecave et al, 2008","Nucleic acid-binding proteins","Redox-sensitive transcriptional activator SoxR","No annotation","2Fe-2S; 3D-structure; Activator; Complete proteome; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transcription; Transcription regulation"]
["P77667","SUFA_ECOLI","0.652504","TP","Fontecave et al, 2008","Metallosite assembly","Protein SufA","No annotation","3D-structure; Complete proteome; Reference proteome"]
["P77522","SUFB_ECOLI","<0.5","FN","Fontecave et al, 2008","Metallosite assembly","FeS cluster assembly protein SufB","No annotation","Complete proteome; Reference proteome"]
["P42630","TDCG_ECOLI","<0.5","FN","Fontecave et al, 2008","Non redox catalysis","L-serine dehydratase TdcG (SDH) (EC 4.3.1.17) (L-serine deaminase)","Binds 1 4Fe-4S cluster (Probable).","4Fe-4S; Complete proteome; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P30136","THIC_ECOLI","<0.5","FN","Uniprot",null,"Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC)","Binds 1 4Fe-4S cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Thiamine biosynthesis; Zinc"]
["P30140","THIH_ECOLI","0.960684","TP","Fontecave et al, 2008","RadicalSAM - Redox Catalysis","2-iminoacetate synthase (EC 4.1.99.19) (Dehydroglycine synthase) (Tyrosine lyase)","Binds 1 4Fe-4S cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.","4Fe-4S; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine; Thiamine biosynthesis"]
["P33225","TORA_ECOLI","0.920781","FP","Uniprot",null,"Trimethylamine-N-oxide reductase 1 (TMAO reductase 1) (Trimethylamine oxidase 1) (EC 1.7.2.3)","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Complete proteome; Direct protein sequencing; Metal-binding; Molybdenum; Oxidoreductase; Periplasm; Reference proteome; Signal"]
["P46923","TORZ_ECOLI","0.920781","FP","Uniprot",null,"Trimethylamine-N-oxide reductase 2 (TMAO reductase 2) (Trimethylamine oxidase 2) (EC 1.7.2.3)","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Complete proteome; Direct protein sequencing; Metal-binding; Molybdenum; Oxidoreductase; Periplasm; Reference proteome; Signal"]
["P05847","TTDA_ECOLI","0.791504","TP","Uniprot",null,"L(+)-tartrate dehydratase subunit alpha (L-TTD alpha) (EC 4.2.1.32)","Iron-sulfur.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome"]
["P0AC35","TTDB_ECOLI","0.791504","FP","Uniprot",null,"L(+)-tartrate dehydratase subunit beta (L-TTD beta) (EC 4.2.1.32)","No annotation","Complete proteome; Lyase; Reference proteome"]
["Q46801","XDHC_ECOLI","0.974112","TP","Fontecave et al, 2008","Electron transfert","Xanthine dehydrogenase iron-sulfur-binding subunit","Binds 2 2Fe-2S clusters (By similarity).","2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Purine metabolism; Purine salvage; Reference proteome"]
["Q46814","XDHD_ECOLI","0.852278","TP","Uniprot",null,"Probable hypoxanthine oxidase XdhD (EC 1.-.-.-)","Binds 2 2Fe-2S centers (Potential).; Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit (By similarity).","2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase; Purine metabolism; Purine salvage; Reference proteome"]
["P77165","YAGT_ECOLI","0.927502","TP","Uniprot",null,"Putative xanthine dehydrogenase YagT iron-sulfur-binding subunit","No annotation","2Fe-2S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Purine metabolism; Purine salvage; Reference proteome; Signal"]
["P75764","YBHJ_ECOLI","0.879269","TP","Uniprot",null,"Uncharacterized protein YbhJ","Binds 1 4Fe-4S cluster per subunit (By similarity).","Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["P75863","YCBX_ECOLI","0.943954","FP","Uniprot",null,"Uncharacterized protein YcbX","No annotation","Complete proteome; Reference proteome"]
["P52636","YCCM_ECOLI","0.989267","TP","Uniprot",null,"Putative electron transport protein YccM","No annotation","4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport"]
["P76134","YDEM_ECOLI","0.964241","TP","Uniprot",null,"Anaerobic sulfatase-maturating enzyme homolog YdeM (AnSME homolog)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).; May bind at least one other iron-sulfur cluster (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["P77561","YDEP_ECOLI","0.920781","TP","Uniprot",null,"Protein YdeP","Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome"]
["P76192","YDHV_ECOLI","<0.5","FN","Uniprot",null,"Uncharacterized oxidoreductase YdhV (EC 1.-.-.-)","Binds 1 4Fe-4S cluster per subunit (By similarity).; Binds 1 molybdenum-molybdopterin or 1 tungstopterin cofactor per subunit (By similarity).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome"]
["P77375","YDHX_ECOLI","0.984128","TP","Uniprot",null,"Uncharacterized ferredoxin-like protein YdhX","No annotation","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Signal"]
["P0AAL6","YDHY_ECOLI","0.989267","TP","Uniprot",null,"Uncharacterized ferredoxin-like protein YdhY","No annotation","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat"]
["P77748","YDIJ_ECOLI","0.885572","FP","Uniprot",null,"Uncharacterized protein YdiJ","No annotation","Complete proteome; Reference proteome"]
["P77714","YDIT_ECOLI","0.956353","TP","Uniprot",null,"Ferredoxin-like protein YdiT","No annotation","Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["P0ABR7","YEAW_ECOLI","0.93065","TP","Uniprot",null,"Putative dioxygenase subunit alpha YeaW (EC 1.14.-.-)","Binds 1 2Fe-2S cluster (Probable).; Binds 1 iron ion (Probable).","2Fe-2S; Complete proteome; Dioxygenase; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome"]
["P76254","YEAX_ECOLI","0.873697","TP","Uniprot",null,"Putative dioxygenase subunit beta YeaX (EC 1.-.-.-)","FMN (By similarity).","2Fe-2S; Complete proteome; Electron transport; FMN; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transport"]
["P0ABW3","YFAE_ECOLI","0.963087","TP","Uniprot",null,"Uncharacterized ferredoxin-like protein YfaE","Binds 1 2Fe-2S cluster (Potential).","2Fe-2S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["P52102","YFHL_ECOLI","0.989267","TP","Uniprot",null,"Uncharacterized ferredoxin-like protein YfhL","No annotation","3D-structure; 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat"]
["P64554","YGCF_ECOLI*","0.945009","TP","Uniprot",null,"7-carboxy-7-deazaguanine synthase (CDG synthase) (EC 4.3.99.3) (Queuosine biosynthesis protein QueE)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).; Binds 1 S-adenosyl-L-methionine per subunit (By similarity).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Queuosine biosynthesis; Reference proteome; S-adenosyl-L-methionine"]
["Q46905","YGCO_ECOLI","0.963377","TP","Uniprot",null,"Ferredoxin-like protein YgcO","No annotation","Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Transport"]
["Q46811","YGFK_ECOLI","0.998689","TP","Uniprot",null,"Uncharacterized protein YgfK","No annotation","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["Q46819","YGFS_ECOLI","0.984128","TP","Uniprot",null,"Putative electron transport protein YgfS","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["Q46820","YGFT_ECOLI","0.996297","TP","Uniprot",null,"Uncharacterized protein YgfT","Binds 4 4Fe-4S clusters (By similarity). May potentially bind 2 additional iron-sulfur clusters.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Repeat"]
["P52062","YGGW_ECOLI","0.936716","TP","Uniprot",null,"Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW (EC 1.3.99.-)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; Reference proteome; S-adenosyl-L-methionine"]
["Q46861","YGIQ_ECOLI","0.964241","TP","Uniprot",null,"UPF0313 protein YgiQ","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["P42626","YHAM_ECOLI","0.834374","FP","Uniprot",null,"UPF0597 protein YhaM","No annotation","Complete proteome; Reference proteome"]
["P0ADW6","YHCC_ECOLI","0.942635","FP","Uniprot",null,"Uncharacterized protein YhcC","No annotation","Complete proteome; Reference proteome"]
["P31449","YIDL_ECOLI","0.538923","FP","Uniprot",null,"Uncharacterized HTH-type transcriptional regulator YidL","No annotation","Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation"]
["P39280","YJEK_ECOLI*","0.964241","TP","Uniprot",null,"L-lysine 2,3-aminomutase (LAM) (EC 5.4.3.-) (EF-P post-translational modification enzyme B)","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; Pyridoxal phosphate.","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Isomerase; Metal-binding; Pyridoxal phosphate; Reference proteome; S-adenosyl-L-methionine"]
["P39288","YJES_ECOLI*","0.937652","TP","Uniprot",null,"Epoxyqueuosine reductase (EC 1.1.-.-) (Queuosine biosynthesis protein QueG)","No annotation","4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Queuosine biosynthesis; Reference proteome; tRNA processing"]
["P39383","YJIL_ECOLI","<0.5","FN","Uniprot",null,"Uncharacterized protein YjiL","Binds 1 4Fe-4S cluster per dimer (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome"]
["P39384","YJIM_ECOLI","0.801225","FP","Uniprot",null,"Uncharacterized protein YjiM","No annotation","Complete proteome; Reference proteome"]
["P39409","YJJW_ECOLI","0.999699","TP","Uniprot",null,"Uncharacterized protein YjjW","Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).; Binds 2 4Fe-4S clusters (Potential).","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; S-adenosyl-L-methionine"]
["P77536","YKGF_ECOLI","0.983437","TP","Uniprot",null,"Uncharacterized electron transport protein YkgF","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P77374","YNFE_ECOLI","0.954335","TP","Uniprot",null,"Putative dimethyl sulfoxide reductase chain YnfE (DMSO reductase) (EC 1.8.99.-)","Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","4Fe-4S; Cell membrane; Complete proteome; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome; Signal"]
["P77783","YNFF_ECOLI","0.954335","TP","Uniprot",null,"Probable dimethyl sulfoxide reductase chain YnfF (DMSO reductase) (EC 1.8.99.-)","Binds 1 4Fe-4S cluster (Potential).; Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","4Fe-4S; Cell membrane; Complete proteome; Iron; Iron-sulfur; Membrane; Metal-binding; Molybdenum; Oxidoreductase; Reference proteome; Signal"]
["P0AAJ1","YNFG_ECOLI","0.984128","TP","Uniprot",null,"Probable anaerobic dimethyl sulfoxide reductase chain YnfG (DMSO reductase iron-sulfur subunit YnfG)","Binds 4 4Fe-4S clusters (By similarity).","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
["P56256","YSAA_ECOLI","0.984128","TP","Uniprot",null,"Putative electron transport protein YsaA","No annotation","4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport"]
[]
[]
["*: YJEK_ECOLI = EPMB_ECOLI"]
["*: YGCF_ECOLI = QUEE_ECOLI"]
["*: YJES_ECOLI = QUEG_ECOLI"]
["*: NSR_ECOLI = YEIL_ECOLI"]
["NB: all the proteins have a reviewed status in SwissProt"]

{"sheet":"Supplementary_Table_7","index":7,"n_rows":19,"n_cols":6,"rows_kept":19,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["ID","Confidence score","Complete name","Enzymatic function","General annotation (cofactor)","Keywords"]
["AHPF_ECOLI",0.7399,"Alkyl hydroperoxide reductase subunit F (EC 1.8.1.-) (Alkyl hydroperoxide reductase F52A protein)","Oxidoreductase","FAD;NAD;NADP","Disulfide bond; FAD; Flavoprotein; NAD; NADP; Oxidoreductase; Redox-active center"]
["BISC_ECOLI",0.9208,"Biotin sulfoxide reductase (BDS reductase) (BSO reductase) (EC 1.-.-.-) (L-methionine-(S)-sulfoxide reductase) (Met-S-SO reductase) (EC 1.8.4.13)","Oxidoreductase","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (Probable).","Metal-binding; Molybdenum; Oxidoreductase"]
["GLPA_ECOLI",0.7701,"Anaerobic glycerol-3-phosphate dehydrogenase subunit A (G-3-P dehydrogenase) (EC 1.1.5.3)","Dehydrogenase","FAD; FMN","FAD; Flavoprotein; Membrane; Oxidoreductase;"]
["MUG_ECOLI",0.746,"G/U mismatch-specific DNA glycosylase (EC 3.2.2.28) (Double-strand-specific uracil glycosylase) (Mismatch-specific uracil DNA-glycosylase) (MUG)","Hydrolase","DNA binding","DNA damage; DNA excision; DNA repair; DNA-binding; Glycosidase; Hydrolase"]
["NIRD_ECOLI",0.8156,"Nitrite reductase (NADH) small subunit (EC 1.7.1.15)","Oxidoreductase","siroheme; NAD; FAD; [FeS] iron-sulfur cluster","NAD; Nitrate assimilation; Oxidoreductase"]
["PRET_ECOLI*",0.74,"NAD-dependent dihydropyrimidine dehydrogenase subunit PreT (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)","Oxidoreductase","NAD","NAD; Oxidoreductase"]
["TORA_ECOLI",0.92,"Trimethylamine-N-oxide reductase 1 (TMAO reductase 1) (Trimethylamine oxidase 1) (EC 1.7.2.3)","Oxidoreductase","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity); Besides molybdenum, iron and zinc are also present in the enzyme.","Metal-binding; Molybdenum; Oxidoreductase"]
["TORZ_ECOLI",0.9208,"Trimethylamine-N-oxide reductase 2 (TMAO reductase 2) (Trimethylamine oxidase 2) (EC 1.7.2.3)","Oxidoreductase","Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit (By similarity).","Metal-binding; Molybdenum; Oxidoreductase"]
["TTDB_ECOLI",0.7915,"L(+)-tartrate dehydratase subunit beta (L-TTD beta) (EC 4.2.1.32)","Dehydratase","-","Lyase"]
["YCBX_ECOLI",0.94,"Uncharacterized protein YcbX","-","-","-"]
["YDIJ_ECOLI",0.8389,"Uncharacterized protein YdiJ","Oxidoreductase","-","-"]
["YHAM_ECOLI",0.8344,"UPF0597 protein YhaM","-","-","-"]
["YHCC_ECOLI",0.9426,"Uncharacterized protein YhcC","Oxidoreductase","-","-"]
["YIDL_ECOLI",0.5389,"Uncharacterized HTH-type transcriptional regulator YidL","-","DNA binding","DNA-binding; Transcription; Transcription regulation"]
["YJIM_ECOLI",0.8012,"Uncharacterized protein yjiM","-","-","-"]
[]
["*:PRET_ECOLI= YEIT=ECOLI"]
["Annotation source: UniprotKB"]

{"sheet":"Supplementary_Table_8","index":8,"n_rows":100,"n_cols":9,"rows_kept":100,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Entry name (UniProtKB)","InFeS Score\n(Extended Model)","InFeS status","InterPro hits","IPR status","FeS annotation source ","Protein names"]
["ACON1_ECOLI","0.879269","TP","4Fe-4S cluster binding site (IPR018136)","TP","Fontecave et al, 2008","Aconitate hydratase 1 (Aconitase 1) (EC 4.2.1.3) (Citrate hydro-lyase 1)"]
["ACON2_ECOLI","0.879269","TP","4Fe-4S cluster binding site (IPR018136)","TP","Fontecave et al, 2008","Aconitate hydratase 2 (Aconitase) (EC 4.2.1.3) (2-methylisocitrate dehydratase) (EC 4.2.1.99) (Citrate hydro-lyase)"]
["ASLB_ECOLI","0.934953","TP","4Fe4S-binding SPASM domain (IPR023885)","TP","Fontecave et al, 2008","Anaerobic sulfatase-maturating enzyme homolog AslB (AnSME homolog)"]
["BFD_ECOLI","0.770116","TP","BFD-like [2Fe-2S]-binding domain (IPR007419)","TP","Fontecave et al, 2008","Bacterioferritin-associated ferredoxin"]
["BIOB_ECOLI","0.964241","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","Biotin synthase (EC 2.8.1.6)"]
["CYSI_ECOLI","0.754316","TP","Nitrite/sulphite reductase 4Fe-4S domain (IPR006067)","TP","Fontecave et al, 2008","Sulfite reductase [NADPH] hemoprotein beta-component (SiR-HP) (SiRHP) (EC 1.8.1.2)"]
["DHSB_ECOLI","0.998669","TP","2Fe-2S ferredoxin-type domain (IPR001041); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Succinate dehydrogenase iron-sulfur subunit (EC 1.3.99.1)"]
["DING_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Ren et al, 2008","Probable ATP-dependent helicase DinG (EC 3.6.4.12) (DNA-damage-inducible protein G)"]
["DMSA_ECOLI","0.904143","TP","Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","TP","Fontecave et al, 2008","Dimethyl sulfoxide reductase DmsA (DMSO reductase) (DMSOR) (Me2SO reductase) (EC 1.8.5.3)"]
["DMSB_ECOLI","0.984128","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Anaerobic dimethyl sulfoxide reductase chain B (DMSO reductase iron-sulfur subunit)"]
["END3_ECOLI","0.883615","TP","Endonuclease III, iron-sulphur binding site (IPR004035)","TP","Fontecave et al, 2008","Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase)"]
["ERPA_ECOLI","0.944284","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Iron-sulfur cluster insertion protein ErpA"]
["FADH_ECOLI","0.759676","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","2,4-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34) (2,4-dienoyl coenzyme A reductase)"]
["FDHD_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Protein FdhD"]
["FDHF_ECOLI","0.954335","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Formate dehydrogenase H (EC 1.1.99.33) (EC 1.2.1.2) (Formate dehydrogenase-H subunit alpha) (FDH-H) (Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide)"]
["FDNG_ECOLI","0.954335","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Formate dehydrogenase, nitrate-inducible, major subunit (EC 1.2.1.2) (Anaerobic formate dehydrogenase major subunit) (Formate dehydrogenase-N subunit alpha) (FDH-N subunit alpha)"]
["FDNH_ECOLI","0.984128","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (Anaerobic formate dehydrogenase iron-sulfur subunit) (Formate dehydrogenase-N subunit beta) (FDH-N subunit beta)"]
["FDOG_ECOLI","0.954335","TP","Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","TP","Fontecave et al, 2008","Formate dehydrogenase-O major subunit (EC 1.2.1.2) (Aerobic formate dehydrogenase major subunit) (FDH-Z subunit alpha) (Formate dehydrogenase-O subunit alpha)"]
["FDOH_ECOLI","0.984128","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Formate dehydrogenase-O iron-sulfur subunit (Aerobic formate dehydrogenase iron-sulfur subunit) (FDH-Z subunit beta) (Formate dehydrogenase-O subunit beta)"]
["FER_ECOLI","0.953463","TP","2Fe-2S ferredoxin-type domain (IPR001041); Ferredoxin, 2Fe-2S type (IPR011536); Adrenodoxin, iron-sulphur binding site (IPR018298)","TP","Fontecave et al, 2008","2Fe-2S ferredoxin"]
["FHUF_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Ferric iron reductase protein FhuF"]
["FNR_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Fumarate and nitrate reduction regulatory protein"]
["FRDB_ECOLI","0.999147","TP","2Fe-2S ferredoxin-type domain (IPR001041); 2Fe-2S ferredoxin, iron-sulphur binding site (IPR006058); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Fumarate reductase iron-sulfur subunit (EC 1.3.99.1)"]
["FUMA_ECOLI","0.791504","TP","Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain (IPR004646); Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain (IPR004647)","TP","Fontecave et al, 2008","Fumarate hydratase class I, aerobic (Fumarase) (EC 4.2.1.2)"]
["FUMB_ECOLI","<0.5","FN","Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain (IPR004646); Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain (IPR004647)","TP","Fontecave et al, 2008","Fumarate hydratase class I, anaerobic (Fumarase) (EC 4.2.1.2)"]
["GLPB_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Anaerobic glycerol-3-phosphate dehydrogenase subunit B (Anaerobic G-3-P dehydrogenase subunit B) (Anaerobic G3Pdhase B) (EC 1.1.5.3)"]
["GLTB_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Glutamate synthase [NADPH] large chain (EC 1.4.1.13) (Glutamate synthase subunit alpha) (GLTS alpha chain) (NADPH-GOGAT)"]
["GLTD_ECOLI","0.929065","TP","4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896)","TP","Fontecave et al, 2008","Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (NADPH-GOGAT)"]
["HCAC_ECOLI","0.931131","TP","Rieske [2Fe-2S] iron-sulphur domain (IPR017941)","TP","Fontecave et al, 2008","3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit (Digoxigenin ferredoxin subunit)"]
["HCP_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP)"]
["HCR_ECOLI","0.96527","TP","2Fe-2S ferredoxin-type domain (IPR001041)","TP","Fontecave et al, 2008","NADH oxidoreductase hcr (EC 1.-.-.-)"]
["HEMN_ECOLI","0.931135","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","Oxygen-independent coproporphyrinogen-III oxidase (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.99.22)"]
["HYBA_ECOLI","0.999159","TP","4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Hydrogenase-2 operon protein HybA"]
["HYCB_ECOLI","0.989267","TP","4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Formate hydrogenlyase subunit 2 (FHL subunit 2) (Hydrogenase-3 component B)"]
["HYCF_ECOLI","0.989267","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Formate hydrogenlyase subunit 6 (FHL subunit 6) (Hydrogenase-3 component F)"]
["HYCG_ECOLI","0.662396","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Formate hydrogenlyase subunit 7 (FHL subunit 7) (Hydrogenase-3 component G)"]
["HYFA_ECOLI","0.984128","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Hydrogenase-4 component A (EC 1.-.-.-)"]
["HYFH_ECOLI","0.989267","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Hydrogenase-4 component H"]
["HYFI_ECOLI","0.947304","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Hydrogenase-4 component I (EC 1.-.-.-)"]
["HYFR_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Hydrogenase-4 transcriptional activator"]
["ILVD_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9)"]
["ISCA_ECOLI","0.944284","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Iron-binding protein IscA (Iron-sulfur cluster assembly protein)"]
["ISCR_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","HTH-type transcriptional regulator IscR"]
["ISPG_ECOLI","0.621177","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein GcpE) (Protein E)"]
["ISPH_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2)"]
["LEUC_ECOLI","0.879269","TP","Aconitase family, 4Fe-4S cluster binding site (IPR018136)","TP","Fontecave et al, 2008","3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)"]
["LIPA_ECOLI","0.954044","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)"]
["MBHS_ECOLI","0.947304","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase)"]
["MBHT_ECOLI","0.699027","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Hydrogenase-2 small chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 small subunit) (NiFe hydrogenase)"]
["MIAB_ECOLI","0.942635","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB (EC 2.-.-.-) (tRNA-i(6)A37 methylthiotransferase)"]
["MOAA_ECOLI","0.94471","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A)"]
["MUTY_ECOLI","0.900055","TP","Endonuclease III, iron-sulphur binding site (IPR004035)","TP","Fontecave et al, 2008","A/G-specific adenine glycosylase (EC 3.2.2.-)"]
["NADA_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Quinolinate synthase A (EC 2.5.1.72)"]
["NAPA_ECOLI","0.895513","TP","Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","TP","Fontecave et al, 2008","Periplasmic nitrate reductase (EC 1.7.99.4)"]
["NAPF_ECOLI","0.989267","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900); Ferredoxin-type protein NapF (IPR004496)","TP","Fontecave et al, 2008","Ferredoxin-type protein NapF"]
["NAPG_ECOLI","0.997982","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Ferredoxin-type protein NapG"]
["NAPH_ECOLI","0.989267","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Ferredoxin-type protein NapH"]
["NARG_ECOLI","0.954335","TP","Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","TP","Fontecave et al, 2008","Respiratory nitrate reductase 1 alpha chain (EC 1.7.99.4) (Nitrate reductase A subunit alpha) (Quinol-nitrate oxidoreductase subunit alpha)"]
["NARH_ECOLI","0.975065","TP","4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896)","TP","Fontecave et al, 2008","Respiratory nitrate reductase 1 beta chain (EC 1.7.99.4) (Nitrate reductase A subunit beta) (Quinol-nitrate oxidoreductase subunit beta)"]
["NARY_ECOLI","0.98163","TP","4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896)","TP","Fontecave et al, 2008","Respiratory nitrate reductase 2 beta chain (EC 1.7.99.4)"]
["NARZ_ECOLI","0.89543","TP","Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","TP","Fontecave et al, 2008","Respiratory nitrate reductase 2 alpha chain (EC 1.7.99.4)"]
["NFUA_ECOLI","0.695862","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Fe/S biogenesis protein NfuA"]
["NIFU_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","NifU-like protein"]
["NIRB_ECOLI","0.956611","TP","Nitrite/sulphite reductase 4Fe-4S domain (IPR006067); BFD-like [2Fe-2S]-binding domain (IPR007419)","TP","Fontecave et al, 2008","Nitrite reductase (NADH) large subunit (EC 1.7.1.15)"]
["NRDG_ECOLI","0.911923","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Anaerobic ribonucleoside-triphosphate reductase-activating protein (EC 1.97.1.-) (Class III anaerobic ribonucleotide reductase small component)"]
["NRFC_ECOLI","0.984128","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Protein NrfC"]
["NSR_ECOLI*","0.538923","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Regulatory protein YeiL"]
["NSRR_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","HTH-type transcriptional repressor NsrR"]
["NUOB_ECOLI","0.947304","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","NADH-quinone oxidoreductase subunit B (EC 1.6.99.5) (NADH dehydrogenase I subunit B) (NDH-1 subunit B) (NUO2)"]
["NUOE_ECOLI","0.722753","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","NADH-quinone oxidoreductase subunit E (EC 1.6.99.5) (NADH dehydrogenase I subunit E) (NDH-1 subunit E) (NUO5)"]
["NUOF_ECOLI","0.880264","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","NADH-quinone oxidoreductase subunit F (EC 1.6.99.5) (NADH dehydrogenase I subunit F) (NDH-1 subunit F) (NUO6)"]
["NUOG_ECOLI","0.999656","TP","2Fe-2S ferredoxin-type domain (IPR001041); Molybdopterin oxidoreductase, 4Fe-4S domain (IPR006963)","TP","Fontecave et al, 2008","NADH-quinone oxidoreductase subunit G (EC 1.6.99.5) (NADH dehydrogenase I subunit G) (NDH-1 subunit G) (NUO7)"]
["NUOI_ECOLI","0.989267","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","NADH-quinone oxidoreductase subunit I (EC 1.6.99.5) (NADH dehydrogenase I subunit I) (NDH-1 subunit I) (NUO9)"]
["PAAE_ECOLI","0.943954","TP","2Fe-2S ferredoxin-type domain (IPR001041); 2Fe-2S ferredoxin, iron-sulphur binding site (IPR006058)","TP","Grishin et al, 2011","1,2-phenylacetyl-CoA epoxidase, subunit E (EC 1.-.-.-) (1,2-phenylacetyl-CoA epoxidase, reductase subunit) (1,2-phenylacetyl-CoA monooxygenase, subunit E)"]
["PFLA_ECOLI","0.960986","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 1) (PFL-activating enzyme 1)"]
["PHNJ_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Kamat et al, 2011","Binds 1 4Fe-4S cluster per subunit.; S-adenosyl-L-methionine.","Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase (PRPn C-P lyase) (EC 4.7.1.1)","4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; S-adenosyl-L-methionine"]
["RIMO_ECOLI","0.942016","TP","Radical SAM (IPR007197); Radical SAM, alpha/beta horseshoe (IPR023404)","TP","Fontecave et al, 2008","Ribosomal protein S12 methylthiotransferase RimO (S12 MTTase) (S12 methylthiotransferase) (EC 2.-.-.-) (Ribosome maturation factor RimO)"]
["RLMN_ECOLI","0.956874","TP","Radical SAM (IPR007197)","TP","Grove et al., 2011","Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.-) (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase)"]
["RNFB_ECOLI","0.989267","TP","4Fe-4S domain (IPR007202); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Electron transport complex protein RnfB"]
["RNFC_ECOLI","0.945421","TP","4Fe-4S binding domain (IPR001450); 4Fe-4S ferredoxin-type, iron-sulpur binding domain (IPR017896); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)","TP","Fontecave et al, 2008","Electron transport complex protein RnfC"]
["RUMA_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD (EC 2.1.1.190) (23S rRNA(m5U1939)-methyltransferase)"]
["SDHL_ECOLI","0.834374","TP","Iron-sulphur-dependent L-serine dehydratase single chain form (IPR004644)","TP","Fontecave et al, 2008","L-serine dehydratase 1 (SDH 1) (EC 4.3.1.17) (L-serine deaminase 1) (L-SD1)"]
["SDHM_ECOLI","0.834374","TP","Iron-sulphur-dependent L-serine dehydratase single chain form (IPR004644)","TP","Fontecave et al, 2008","L-serine dehydratase 2 (SDH 2) (EC 4.3.1.17) (L-serine deaminase 2) (L-SD2)"]
["SOXR_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Redox-sensitive transcriptional activator SoxR"]
["SUFA_ECOLI","0.652504","TP","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","Protein SufA"]
["SUFB_ECOLI","<0.5","FN","No Iron-Sulfur binding hit","FN","Fontecave et al, 2008","FeS cluster assembly protein SufB"]
["TDCG_ECOLI","<0.5","FN","Iron-sulphur-dependent L-serine dehydratase single chain form (IPR004644)","TP","Fontecave et al, 2008","L-serine dehydratase TdcG (SDH) (EC 4.3.1.17) (L-serine deaminase)"]
["THIH_ECOLI","0.960684","TP","Radical SAM (IPR007197)","TP","Fontecave et al, 2008","2-iminoacetate synthase (EC 4.1.99.19) (Dehydroglycine synthase) (Tyrosine lyase)"]
["XDHC_ECOLI","0.974112","TP","2Fe-2S ferredoxin-type domain (IPR001041); [2Fe-2S]-binding (IPR002888)","TP","Fontecave et al, 2008","Xanthine dehydrogenase iron-sulfur-binding subunit"]
["YAGT_ECOLI","0.927502","TP","2Fe-2S ferredoxin-type domain (IPR001041); [2Fe-2S]-binding (IPR002888); 2Fe-2S ferredoxin, iron-sulphur binding site (IPR006058)","TP","Neumann et al, 2009","Putative xanthine dehydrogenase YagT iron-sulfur-binding subunit"]
["YEAW_ECOLI","0.93065","TP","Rieske [2Fe-2S] iron-sulphur domain (IPR017941)","TP","Boxhammer et al., 2008","Putative dioxygenase subunit alpha YeaW (EC 1.14.-.-)"]
["YFAE_ECOLI","0.963087","TP","2Fe-2S ferredoxin-type domain (IPR001041); 2Fe-2S ferredoxin, iron-sulphur binding site (IPR006058)","TP","Wu et al., 2007","Uncharacterized ferredoxin-like protein YfaE"]
["YJEK_ECOLI*","0.964241","TP","Radical SAM (IPR007197)","TP","Behshad et al., 2006","L-lysine 2,3-aminomutase (LAM) (EC 5.4.3.-) (EF-P post-translational modification enzyme B)"]
[]
[]
["TP Infes = 74 / 93 = 79.5%"]
["FN Infes = 20 / 93 = 21.5%"]
["TP IPR = 59/ 93  =  63.4%"]
["FN IPR =34 / 93 = 36.5%"]

{"sheet":"Supplementary_Table_9","index":9,"n_rows":24,"n_cols":12,"rows_kept":24,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Organism","ID_HAMAP","Kingdom","Lineage","Total protein","Total Fe-S proteins","Fe-S proteins ratio","Oxygen Requirement*","Habitat*","Temperature range*","Energy Source*","Metabolism*"]
["Dehalococcoides sp. CBDB1","DEHSC","Bacteria","Chloroflexi",1454,101,6.94635488308116,"Anaerobic","Aquatic","Mesophilic","Chemolithotroph","Dechlorinates Tetrachloroethene"]
["Desulfitobacterium hafniense DCB-2","DESHD","Bacteria","Firmicutes",4852,311,6.40972794723825,"Anaerobic","Sludge, Wastewater","Mesophilic","NA","Degrades pollutants"]
["Slackia heliotrinireducens DSM 20476","SLAHD","Bacteria","Actinobacteria",2750,173,6.29090909090909,"Anaerobic","Host_associated","Mesophilic","NA","Pyrrolizidine alkaloids metabolizer"]
["Methanococcus aeolicus Nankai-3","META3","Archaea","Euryarchaeota",1490,93,6.24161073825503,"Anaerobic","Aquatic","Mesophilic","Lithotroph","Methanogen"]
["Methanothermus fervidus DSM 2088","METFV","Archaea","Euryarchaeota",1283,79,6.15744349181606,"Anaerobic","Aquatic","Hyperthermophilic","NA","Methanogen"]
["Moorella thermoacetica ATCC 39073","MOOTA","Bacteria","Firmicutes",2451,150,6.11995104039168,"Anaerobic","Aquatic","Thermophilic","NA","Acetogen, Carbon dioxide fixation"]
["Syntrophobacter fumaroxidans MPOB","SYNFM","Bacteria","Deltaproteobacteria",4012,233,5.80757726819541,"Anaerobic","Fresh water, Sludge, Wastewater","Mesophilic","NA","Propionate metabolism"]
["Methanococcus maripaludis S2","METMP","Archaea","Euryarchaeota",1722,100,5.80720092915215,"Anaerobic","Aquatic","Mesophilic","NA","Methanogen"]
["Dehalococcoides ethenogenes 195","DEHE1","Bacteria","Chloroflexi",1502,87,5.79227696404794,"Anaerobic","Aquatic","Mesophilic","Chemolithotroph","Dechlorinates Tetrachloroethene"]
["Desulfococcus oleovorans Hxd3","DESOH","Bacteria","Deltaproteobacteria",3255,186,5.71428571428571,"Anaerobic","Fresh water, Oil fields, Mud, Aquatic","Mesophilic","NA","Alkane degrader, Sulfate reducer"]
["Methanocaldococcus fervens AG86","METFA","Archaea","Euryarchaeota",1546,87,5.627425614489,"Anaerobic","Aquatic","Hyperthermophilic","Autotroph, Lithotroph","Methanogen"]
["Carboxydothermus hydrogenoformans Z-2901","CARHZ","Bacteria","Firmicutes",2615,147,5.62141491395794,"Anaerobic","Aquatic","Hyperthermophilic","Chemolithotroph","NA"]
["Methanocaldococcus sp. FS406-22","METSF","Archaea","Euryarchaeota",1803,101,5.60177481974487,"Anaerobic","Aquatic","Thermophilic","Lithotroph","Methanogen, Nitrogen fixation"]
["Methanococcus vannielii SB","METVS","Archaea","Euryarchaeota",1661,93,5.59903672486454,"Anaerobic","Aquatic","Mesophilic","Lithotroph","Methanogen"]
["Methanohalophilus mahii DSM 5219","METMS","Archaea","Euryarchaeota",1986,108,5.4380664652568,"Anaerobic","Aquatic","Mesophilic","Methylotroph","Methanogen"]
["Methanococcus voltae A3","METV3","Archaea","Euryarchaeota",1658,90,5.42822677925211,"Anaerobic","Aquatic","Mesophilic","Lithotroph","Methanogen"]
["Methanothermobacter thermautotrophicus str. Delta H","METTH","Archaea","Euryarchaeota",1869,101,5.40395933654361,"Anaerobic","Wasted water","Thermophilic","Lithoautotroph, Autotroph, Lithotroph","Methanogen"]
["Methanopyrus kandleri AV19","METKA","Archaea","Euryarchaeota",1687,91,5.39419087136929,"Anaerobic","Aquatic","Hyperthermophilic","Lithotroph","Methanogen"]
["Methanocaldococcus infernus ME","METIM","Archaea","Euryarchaeota",1439,77,5.35093815149409,"Anaerobic","Aquatic","Hyperthermophilic","Autotroph, Lithotroph","Methanogen"]
["Ferroglobus placidus DSM 10642","FERPA","Archaea","Euryarchaeota",2463,131,5.31871701177426,"Anaerobic","Aquatic","Hyperthermophilic","Chemolithotroph, Chemoorganotroph","Iron oxidizer"]
[]
["*: Source Integrated Microbial Genomes (http://img.jgi.doe.gov/cgi-bin/w/main.cgi)"]
["NA: non available"]