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Caption : supplementary fig 1 synthesis of plumbagin caged silver nanoparticles. photographic representation of a) silver nitrate solution alone b) silver oxide nanoparticles (reduced with koh) and c) plumbagin caged silver nanoparticles.

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Caption : supplementary fig 2 caging efficiency of plumbagin on silver nanoparticles was determined after solubilization in alcoholic koh. a) supernatant from control nanoparticles after treatment with alcoholic koh b) supernatant from plumbagin caged silver nanoparticles after treatment with alcoholic koh. the supernatant was used to quantitate the plumbagin loading efficiency on silver nanoparticles using uv-vis spectroscopy and ft-ir analysis

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Caption : supplementary fig 3 flow cytometric quantification of apoptosis induced by plumbagin and plumabagin caged silver nanoparticle. hacat and a431 cells were treated with plumbagin caged silver nanoparticle and plumbagin at 2.5 µm and 5 µm concentrations and incubated for 6 hrs at 37ºc. the cells were then stained with annexin-fitc and pi for 30 mins at dark and the cells were harvested and quantified using flow cytometer (bd bioscience). p1, p2 illustrated the a431 and hacat treated with 2.5 µm and 5 µm of plumbagin concentration respectively. pn1 and pn2 
illustrated that the both cells a431 and hacat treated with 2.5 µm and 5 µm concentration of plumbagin caged silver nanoparticle respectively.


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Caption : supplementary fig 4 a) dynamic light scattering analysis of the control silver nanoparticle synthesised by citrate reduction method in presence of ascorbic acid. b) scanning electron microphotograph of control silver nanoparticle. c) effect of control silver nanoparticle having size similar to pcsn on cell viability of a431 and hacat cells; a- untreated control, b, c, and d represents the concentrations corresponding to 1.25 µm, 2.5 µm, 5 µm  pcsn respectively.

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Caption : supplementary fig 5 effect of control silver nanoparticle having size similar to pcsn on apoptosis: a, b and c represents the concentrations of control nanoparticle corresponding 1.25 µm, 2.5 µm, 5 µm  of pcsn. a, b, c – phase contrast images of a431 cells; d, e, f – fluorescence images of  a431  cells. g, h, i – phase contrast images of hacat cells; j, k, l – fluorescent images of  hacat  cells. 

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Caption : supplementary fig 6 zeta potential measurement of a) control silver nanoparticle. b) pcsn nanoparticle.