{"text_format":"2","workbook":"xls","n_sheets":10,"sheets":["1998-2003","2003","2002","2001","2000","1999","1998","Chart1","Chart2","NDAs"],"not_rendered":{"charts":6,"images":0,"macros":0,"external_links":1,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[{"sheet":"Chart1","index":7,"reason":"not_a_worksheet"},{"sheet":"Chart2","index":8,"reason":"not_a_worksheet"}],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1904","formulas":"cached_only"}

{"sheet":"1998-2003","index":0,"n_rows":150,"n_cols":14,"rows_kept":150,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number ","Generic Name","Trade Name","Dosage Form","Applicant","*Classification","Approval Date","Year",null,"Year","NMEs","Significant","Difference","% Significant"]
[21481,"Enfuvirtide    ","Fuzeon","Injectable","Roche","1P","03-13-03",2003,null,"2003 so far",4,3,1,75]
[21106,"Pegvisomant","Somavert ","Injectable","Pharmacia and Upjohn","1PV","03-25-03",2003,null,2002,17,7,10,41.17647058823529]
[21549,"Aprepitant","Emend","Capsule","Merck","1P","03-26-03",2003,null,2001,24,7,17,29.166666666666668]
[21158,"Gemifloxacin Mesylate","Factive","Tablet","LG Life Sci","1S","2003-04-04",2003,null,2000,27,9,18,33.33333333333333]
["21-232","Nitisinone","Orfadin","Capsule","Swedish Orphan","1PV","01-18-2002",2002,null,1999,35,19,16,54.285714285714285]
["21-286","Olmesartan Medoxomil","Benicar","Tablet","Sankyo ","1S","04-25-2002",2002,null,1998,30,16,14,53.333333333333336]
["21-344","Fulvestrant","Faslodex","Injection","AstraZeneca","1S","04-25-2002",2002,null,"Total",137,61,76,44.52554744525548]
["21-272","Treprostinil Sodium","Remodulin","Injection","United Therapeutics","1PV","05-21-2002",2002]
["21-266","Voriconazole","VFEND","Tablet","Pfizer","1S","05-24-2002",2002]
["21-191","Dimyristoylphosphatidylcholine/Perflexane","Imagent Kit for the Preparation of Perflexane Lipid Microspheres ","Injectable Suspension","Alliance Pharm","1S","05-31-02",2002]
["21-196","Sodium Oxybate","Xyrem","Solution","Orphan Medical","1PV","07-17-02",2002]
["21-200","Tegaserod Maleate","Zelnorm","Tablet","Novartis","1P","07-24-02",2002]
["21-492","Oxaliplatin ","Eloxatin","Injection","Sanofi","1P","2002-09-08",2002]
["21-449","Adefovir Dipivoxil","HEPSERA","Tablet","Gilead ","1P","09-20-02",2002]
["21-437","Eplerenone","Inspra","Tablet","GD Searle","1S","09-27-02",2002]
["21-445","Ezetimibe","Zetia","Tablet","MSP Singapore","1S","10-25-02",2002]
["21-436","Aripiprazole","Abilify","Tablet","Otsuka ","1S","11-15-02",2002]
["21-498","Nitazoxanide    ","Alinia","Suspension","Romark","1PV   ","11-22-02",2002]
["21-411","Atomoxetine Hydrochloride      ","Strattera","Capsule","Lilly","1S     ","11-26-02",2002]
["21-321","Icodextrin","Extraneal","Solution","Baxter Healthcare ","1SV","12-20-02",2002]
["21-016","Eletriptan Hydrobromide","Relpax","Tablet","Pfizer ","1S","12-26-02",2002]
["21-227","Caspofungin Acetate","Cancidas","Injection","Merck Res","1P","01-26-2001",2001]
["20-825","Ziprasidone Hydrochloride","Geodon","Capsule","Pfizer Medicinal","1S","2001-05-02",2001]
["20-831","Formoterol Fumarate","Foradil Aerolizer","Capsule, Inhalation Powder","Novartis Pharms","1S","02-16-2001",2001]
["21-169","Galantamine Hydrobromide","Reminyl","Tablet","Janssen Res Foundation","1S","02-28-2001",2001]
["21-257","Travoprost","Travatan","Solution","Alcon Universal","1P","03-16-2001",2001]
["21-275","Bimatoprost","Lumigan","Solution","Allergan","1P","03-16-2001",2001]
["21-001","Almotriptan Malate","Axert","Tablet","Pharmacia & Upjohn","1S","2001-07-05",2001]
["21-335","Imatinib Mesylate","Gleevec","Capsule","Novartis Pharms","1PV","2001-10-05",2001]
["21-098","Drospirenone/Ethinyl Estradiol","Yasmin","Tablet","Berlex Labs","1,4S","2001-11-05",2001]
["21-064","Perflutren Lipid Microsphere","Definity","Injectable","Dupont Pharms","1S","07-31-2001",2001]
["20-920","Nesiritide","Natrecor","Injectable","Scios","1S","2001-10-08",2001]
["21-223","Zoledronic Acid","Zometa","Injectable","Novartis","1P","08-20-2001",2001]
["21-222","Cefditoren Pivoxil","Spectracef","Tablet","Tap Pharm","1S","08-29-2001",2001]
["21-187","Ethinyl Estradiol/Etonogestrel","NuvaRing","Vaginal Ring","Organon","1,4S","2001-03-10",2001]
["21-356","Tenofovir Disoproxil Fumarate","Viread","Tablet","Gilead Sciences","1P","10-26-2001",2001]
["21-006","Frovatriptan","Frova","Tablet","Elan Pharms","1S","2001-08-11",2001]
["21-341","Valdecoxib","Bextra","Tablet","Searle Pharms","1S","11-16-2001",2001]
["21-180","Ethinyl Estradiol/Norelgestromin","Ortho Evra","Transdermal System (Contraceptive Patch)","RW Johnson","1,4S","11-20-2001",2001]
["21-290","Bosentan","Tracleer","Tablet","Actelion ","1SV","11-20-2001",2001]
["21-319","Dutasteride","Avodart","Soft-Gelatin Capsule","GlaxoSmithKline","1S","11-20-2001",2001]
["21-337","Ertapenem Sodium","Invanz","Injectable","Merck","1S","11-21-2001",2001]
["21-345","Fondaparinux Sodium","Arixtra","Injectable","Fonda BV","1P","2001-07-12",2001]
["21-302","Pimecrolimus","Elidel","Cream","Novartis Pharms","1S","12-13-2001",2001]
["21-165","Desloratadine","Clarinex","Tablet","Schering","1S","12-21-2001",2001]
["20-989","Cevimeline HCl","Evoxac","Capsule","Snowbrand","1S","2000-11-01",2000]
["21-014","Oxcarbazepine","Trileptal","Tablet","Novartis Pharms","1S","01-14-2000",2000]
["20-987","Pantoprazole Sodium","Protonix","Tablet","Wyeth Ayerst","1S","2000-02-02",2000]
["21-107","Alosetron HC1","Lotronex","Tablet","Glaxo Wellcome","1P","2000-09-02",2000]
["21-084","Perfluoroalkylpolyether (PFPE); Polytetrafluoroethylene (PTFE) ","Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACWA)","Paste","US Army Med Res and Material Command","1,4P","02-17-2000",2000]
["20-789","Zonisamide","Zonegran","Capsule","Elan Pharms","1S","03-27-2000",2000]
["20-971","Articaine HCl 4%; Epinephrine","Septocaine","Injectable","Deproco","1,4S","2000-03-04",2000]
["21-119","Verteporfin","Visudyne","Injectable","QLT PhotoTherapeutics","1P","2000-12-04",2000]
["20-938","Meloxicam","Mobic","Tablet","Boehringer Pharms","1S","04-13-2000",2000]
["21-130","Linezolid","Zyvox","Tablet","Pharmacia and Upjohn","1P","04-18-2000",2000]
["21-081","Insulin Glargine","Lantus","Injectable","Aventis Pharms","1S","04-20-2000",2000]
["20-823","Rivastigmine Tartrate","Exelon","Capsule","Novartis Pharms","1S","04-21-2000",2000]
["21-174","Gemtuzumab Ozogamicin","Mylotarg","Injectable","Wyeth Ayerst","1PV","05-17-2000",2000]
["21-176","Colesevelam HCl","Welchol","Tablet","GelTex","1S","05-26-2000",2000]
["20-986","Insulin Aspart Recombinant","NovoLog","Injectable","Novo Nordisk","1S","2000-07-06",2000]
["20-715","Triptorelin Pamoate","Trelstar Depot","Injectable","Debio Recherche","1S","06-15-2000",2000]
["20-883","Argatroban","Acova","Injectable","Texas Biotech","1S","06-30-2000",2000]
["20-484","Tinzaparin Sodium","Innohep","Injectable","Dupont Pharms","1S","07-14-2000",2000]
["20-610","Balsalazide Disodium`","Colazal","Capsule","Salix Pharms","1S","07-18-2000",2000]
["20-941","Docosanol ","Abreva","Cream","Avanir Pharm","1S","07-25-2000",2000]
["21-214","Unoprostone Isopropyl","Rescula","Solution","Ciba Vision","1P","2000-03-08",2000]
["21-197","Cetrorelix Acetate","Cetrotide","Injectable","Asta Medica","1S","2000-11-08",2000]
["21-226","Lopinavir;Ritonavir","Kaletra","Capsule","Abbott Labs","1,4P","09-15-2000",2000]
["21-248","Arsenic Trioxide","Trisenox","Injectable","Cell Therapeutics","1PV","09-25-2000",2000]
["20-687","Mifepristone","Mifeprex","Tablet","Population Council","1P","09-28-2000",2000]
["20-873","Bivalirudin","Angiomax","Injectable","The Medicines Co","1S","12-15-2000",2000]
["21-204","Nateglinide","Starlix","Tablet","Novartis","1S","12-22-2000",2000]
["20-863","Cilostazol","Pletal","Tablet","Otsuka Pharm","1S","01-15-1999",1999]
["20-886","Alitretinoin","Panretin","Topical Gel","Ligand Pharm","1-PV","1999-02-02",1999]
["20-955","Sodium Ferric Gluconate Complex","Ferrlicit","Injectable","R&D Labs","1P","02-18-1999",1999]
["21-007","Amprenavir","Agenerase","Capsule","Glaxo Wellcome","1P","04-15-1999",1999]
["20-766","Orlistat","Xenical","Capsule","Roche","1P","04-23-1999",1999]
["21-042","Rofecoxib","Vioxx","Tablet","Merck Res","1P","05-20-1999",1999]
["21-071","Rosiglitazone Maleate","Avandia","Tablet","SKB Pharms","1P","05-25-1999",1999]
["20-862","Doxercalciferol","Hectorol","Capsule","Bone Care","1S","1999-09-06",1999]
["21-066","Ketotifen Fumarate","Zaditor","Solution","Ciba Vision","1P","1999-02-07",1999]
["21-073","Pioglitazone HCl","Actos","Tablet","Takeda America","1P","07-15-1999",1999]
["21-036","Zanamivir","Relenza","Powder for Inhalation","Glaxo Wellcome","1P","07-26-1999",1999]
["21-057","Ganirelix Acetate","Antagon","Injectable","Organon","1P","07-29-1999",1999]
["21-012","Kit for the Prep Technetium TC 99M Depreotide","Technetium TC 99M Depreotide Kit","Injectable","Diatide","1P","1999-03-08",1999]
["21-029","Temozolomide","Temodar","Capsule","Schering","1PV","1999-11-08",1999]
["20-859","Zaleplon","Sonata","Capsule","Wyeth Ayerst Labs","1S","08-13-1999",1999]
["20-984","Rapacuronium Bromide","Raplon","Injection","Organon","1S","08-18-1999",1999]
["20-973","Rabeprazole Sodium","Aciphex","Tablet","Eisai (US)","1S","08-19-1999",1999]
["21-083","Sirolimus","Rapamune","Solution","Wyeth Ayerst Labs","1P","09-15-1999",1999]
["50-778","Epirubicin HCl","Ellence","Injectable","Pharmacia and Upjohn","1P","09-15-1999",1999]
["50-747","Dalfopristin/Quinupristin","Synercid","Injectable","Rhone Poulenc Rorer","1P","09-21-1999",1999]
["21-079","Pemirolast Potassium","Alamast","Solution","Santen","1P","09-24-1999",1999]
["20-931","Dofetilide","Tikosyn","Capsule","Pfizer","1S","1999-01-10",1999]
["20-796","Entacapone","Comtan","Tablet","Orion","1S","10-19-1999",1999]
["20-753","Exemestane","Aromasin","Tablet","Pharmacia & Upjohn","1SV","10-21-1999",1999]
["21-087","Oseltamivar Phosphate","Tamiflu","Capsule","Roche","1P","10-27-1999",1999]
["20-744","Poractant","Curosurf","Suspension","Dey Labs","1SV","11-18-1999",1999]
["21-035","Levetiracetam","Keppra","Tablet","UCP Pharma","1S","11-30-1999",1999]
["20-965","Aminolevulinic Acid HCl","Levulan Kerastick","Solution","Dusa","1S","1999-03-12",1999]
["20-937","Gadoversetamide","Optimark","Injectable","Mallinckrodt","1S","1999-08-12",1999]
["20-922","Mequinol; Tretinoin","Solage","Solution","Bristol Myers Squibb","1S","1999-10-12",1999]
["21-085","Moxifloxacin HCl","Avelox","Tablet","Bayer","1S","1999-10-12",1999]
["21-038","Dexmedetomidine HCl","Precedex","Injectable","Abbott Labs","1S","12-17-1999",1999]
["21-061","Gatifloxacin","Tequin","Tablet","Bristol Myers Squibb","1S","12-17-1999",1999]
["20-845","Nitric Oxide","INOmax","Gas for Inhalation","INO Thereapeutics","1PV","12-23-1999",1999]
["21-055","Bexarotene","Targretin","Capsule","Ligand Pharms","1PV","12-29-1999",1999]
["20-697","Tolcapone","Tasmar","Tablet","Roche","1-S","01-29-1998",1998]
["20-763","Naratriptan Hydrochloride","Amerge","Tablet","Glaxo Wellcome","1-S","1998-10-02",1998]
["20-829","Montelukast Sodium","Singulair","Tablet","Merck","1-S","02-20-1998",1998]
["20-807","Lepirudin","Refludan","Powder","Hoechst Marion Roussel","1-PV","1998-06-03",1998]
["20-583","Loteprednol Etabonate","Lotemax","Ophthalmic Suspension","Bausch & Lomb","1-S","1998-09-03",1998]
["20-771","Tolterodine Tartrate","Detrol","Tablet","Pharmacia & Upjohn","1-S","03-25-1998",1998]
["20-835","Risedronate Sodium","Actonel","Tablet","Procter & Gamble","1-S","03-27-1998",1998]
["20-895","Sildenafil Citrate","Viagra","Tablet","Pfizer","1-P","03-27-1998",1998]
["20-816","Brinzolamide","Azopt","Ophthalmic Suspension","Alcon","1-S","1998-01-04",1998]
["20-772","Sacrosidase","Sucraid","Solution","Orphan Medical","1-PV","1998-09-04",1998]
["20-819","Paricalcitol","Zemplar","Injection","Abbott","1-S","04-17-1998",1998]
["20-896","Capecitabine","Xeloda","Tablet","Roche","1-P","04-30-1998",1998]
["20-912","Tirofiban Hydrochloride","Aggrastat","Injection","Merck","1-P","05-14-1998",1998]
["20-718","Eptifibatide","Integrilin","Injection","COR Therapeutics","1-P","05-18-1998",1998]
["20-838","Candesartan Cilexetil","Atacand","Tablet","Astra Merck","1-S","1998-04-06",1998]
["21-024","Rifapentine","Priftin","Tablet","Hoechst Marion Roussel","1-PV","06-22-1998",1998]
["20-864","Rizatriptan Benzoate","Maxalt","Tablet","Merck","1-S","06-29-1998",1998]
["20-785","Thalidomide","Thalomid","Capsule","Celgene","1-PV","07-16-1998",1998]
["20-822","Citalopram Hydrobromide","Celexa","Tablet","Forest Pharms","1-S","07-17-1998",1998]
["20-961","Fomivirsen Sodium","Vitravene","Injection","Isis Pharm","1-P","08-26-1998",1998]
["20-905","Leflunomide","Arava","Tablet","Quintiles","1-P","1998-10-09",1998]
["20-887","Technetium tc 99m Apcitide","AcuTect","Injection","Diatide","1-P","09-14-1998",1998]
["20-972","Efavirenz","Sustiva","Capsule","Dupont Pharm","1-P","09-17-1998",1998]
["20-892","Valrubicin","Valstar","Solution","Anthra Pharm","1-PV","09-25-1998",1998]
["20-926","Sevelamer Hydrochloride","Renagel","Capsule","GelTex Pharm","1-S","10-30-1998",1998]
["20-850","Telmisartan","Micardis","Tablet","Boehringer Ingelheim","1-S","1998-10-11",1998]
["20-898","Thyrotropin Alfa","Thyrogen","Injection","Genzyme","1-PV","11-30-1998",1998]
["20-977","Abacavir Sulfate","Ziagen","Tablet","Glaxo Wellcome","1-P","12-17-1998",1998]
["20-717","Modafinil","Provigil","Tablet","Cephalon","1-SV","12-24-1998",1998]
["20-998","Celecoxib","Celebrex","Capsule","Searle","1-P","12-31-1998",1998]
[]
[]
["*Classification"]
["Chemical Type: "]
["1 - New molecular entity (NME)"]
["4 - New combination"]
[]
[]
["Therapeutic Potentials:   "]
["P -   Priority Review - Significant improvement compared to marketed products, in the treatment, diagnosis, or prevention of a disease."]
["S -   Standard Review - The drug appears to have therapeutic qualities similar to those of one or more already marketed drugs. "]
["V -  Orphan Drug "]

{"sheet":"2003","index":1,"n_rows":19,"n_cols":7,"rows_kept":19,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number ","Generic Name","Trade Name","Dosage Form","Applicant","*Classification","Approval Date"]
[21481,"Enfuvirtide    ","Fuzeon","Injectable","Roche","1P","03-13-03"]
[21106,"Pegvisomant","Somavert ","Injectable","Pharmacia and Upjohn","1PV","03-25-03"]
[21549,"Aprepitant","Emend","Capsule","Merck","1P","03-26-03"]
[21158,"Gemifloxacin Mesylate","Factive","Tablet","LG Life Sci","1S","2003-04-04"]
[]
[]
[]
[]
["*Classification"]
["Chemical Type: "]
["1 - New molecular entity (NME)"]
["4 - New combination"]
[]
[]
["Therapeutic Potentials:   "]
["P -   Priority Review - Significant improvement compared to marketed products, in the treatment, diagnosis, or prevention of a disease."]
["S -   Standard Review - The drug appears to have therapeutic qualities similar to those of one or more already marketed drugs. "]
["V -  Orphan Drug "]

{"sheet":"2002","index":2,"n_rows":30,"n_cols":7,"rows_kept":30,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number ","Generic Name","Trade Name","Dosage Form","Applicant","*Classification","Approval Date"]
["21-232","Nitisinone","Orfadin","Capsule","Swedish Orphan","1PV","01-18-2002"]
["21-286","Olmesartan Medoxomil","Benicar","Tablet","Sankyo ","1S","04-25-2002"]
["21-344","Fulvestrant","Faslodex","Injection","AstraZeneca","1S","04-25-2002"]
["21-272","Treprostinil Sodium","Remodulin","Injection","United Therapeutics","1PV","05-21-2002"]
["21-266","Voriconazole","VFEND","Tablet","Pfizer","1S","05-24-2002"]
["21-191","Dimyristoylphosphatidylcholine/Perflexane","Imagent Kit for the Preparation of Perflexane Lipid Microspheres ","Injectable Suspension","Alliance Pharm","1S","05-31-02"]
["21-196","Sodium Oxybate","Xyrem","Solution","Orphan Medical","1PV","07-17-02"]
["21-200","Tegaserod Maleate","Zelnorm","Tablet","Novartis","1P","07-24-02"]
["21-492","Oxaliplatin ","Eloxatin","Injection","Sanofi","1P","2002-09-08"]
["21-449","Adefovir Dipivoxil","HEPSERA","Tablet","Gilead ","1P","09-20-02"]
["21-437","Eplerenone","Inspra","Tablet","GD Searle","1S","09-27-02"]
["21-445","Ezetimibe","Zetia","Tablet","MSP Singapore","1S","10-25-02"]
["21-436","Aripiprazole","Abilify","Tablet","Otsuka ","1S","11-15-02"]
["21-498","Nitazoxanide    ","Alinia","Suspension","Romark","1PV   ","11-22-02"]
["21-411","Atomoxetine Hydrochloride      ","Strattera","Capsule","Lilly","1S     ","11-26-02"]
["21-321","Icodextrin","Extraneal","Solution","Baxter Healthcare ","1SV","12-20-02"]
["21-016","Eletriptan Hydrobromide","Relpax","Tablet","Pfizer ","1S","12-26-02"]
[]
[]
["*Classification"]
["Chemical Type: "]
["1 - New molecular entity (NME)"]
["4 - New combination"]
[]
[]
["Therapeutic Potentials:   "]
["P -   Priority Review - Significant improvement compared to marketed products, in the treatment, diagnosis, or prevention of a disease."]
["S -   Standard Review - The drug appears to have therapeutic qualities similar to those of one or more already marketed drugs. "]
["V -  Orphan Drug "]

{"sheet":"2001","index":3,"n_rows":37,"n_cols":7,"rows_kept":37,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number ","Generic Name","Trade Name","Dosage Form","Applicant","*Classification","Approval Date"]
["21-227","Caspofungin Acetate","Cancidas","Injection","Merck Res","1P","01-26-2001"]
["20-825","Ziprasidone Hydrochloride","Geodon","Capsule","Pfizer Medicinal","1S","2001-05-02"]
["20-831","Formoterol Fumarate","Foradil Aerolizer","Capsule, Inhalation Powder","Novartis Pharms","1S","02-16-2001"]
["21-169","Galantamine Hydrobromide","Reminyl","Tablet","Janssen Res Foundation","1S","02-28-2001"]
["21-257","Travoprost","Travatan","Solution","Alcon Universal","1P","03-16-2001"]
["21-275","Bimatoprost","Lumigan","Solution","Allergan","1P","03-16-2001"]
["21-001","Almotriptan Malate","Axert","Tablet","Pharmacia & Upjohn","1S","2001-07-05"]
["21-335","Imatinib Mesylate","Gleevec","Capsule","Novartis Pharms","1PV","2001-10-05"]
["21-098","Drospirenone/Ethinyl Estradiol","Yasmin","Tablet","Berlex Labs","1,4S","2001-11-05"]
["21-064","Perflutren Lipid Microsphere","Definity","Injectable","Dupont Pharms","1S","07-31-2001"]
["20-920","Nesiritide","Natrecor","Injectable","Scios","1S","2001-10-08"]
["21-223","Zoledronic Acid","Zometa","Injectable","Novartis","1P","08-20-2001"]
["21-222","Cefditoren Pivoxil","Spectracef","Tablet","Tap Pharm","1S","08-29-2001"]
["21-187","Ethinyl Estradiol/Etonogestrel","NuvaRing","Vaginal Ring","Organon","1,4S","2001-03-10"]
["21-356","Tenofovir Disoproxil Fumarate","Viread","Tablet","Gilead Sciences","1P","10-26-2001"]
["21-006","Frovatriptan","Frova","Tablet","Elan Pharms","1S","2001-08-11"]
["21-341","Valdecoxib","Bextra","Tablet","Searle Pharms","1S","11-16-2001"]
["21-180","Ethinyl Estradiol/Norelgestromin","Ortho Evra","Transdermal System (Contraceptive Patch)","RW Johnson","1,4S","11-20-2001"]
["21-290","Bosentan","Tracleer","Tablet","Actelion ","1SV","11-20-2001"]
["21-319","Dutasteride","Avodart","Soft-Gelatin Capsule","GlaxoSmithKline","1S","11-20-2001"]
["21-337","Ertapenem Sodium","Invanz","Injectable","Merck","1S","11-21-2001"]
["21-345","Fondaparinux Sodium","Arixtra","Injectable","Fonda BV","1P","2001-07-12"]
["21-302","Pimecrolimus","Elidel","Cream","Novartis Pharms","1S","12-13-2001"]
["21-165","Desloratadine","Clarinex","Tablet","Schering","1S","12-21-2001"]
[]
[]
["*Classification"]
["Chemical Type: "]
["1 - New molecular entity (NME)"]
["4 - New combination"]
[]
[]
["Therapeutic Potentials:   "]
["P -   Priority Review - Significant improvement compared to marketed products, in the treatment, diagnosis, or prevention of a disease."]
["S -   Standard Review - The drug appears to have therapeutic qualities similar to those of one or more already marketed drugs. "]
["V -  Orphan Drug "]

{"sheet":"2000","index":4,"n_rows":28,"n_cols":7,"rows_kept":28,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number ","Generic Name","Trade Name","Dosage Form","Applicant","*Classification","Approval Date"]
["20-989","Cevimeline HCl","Evoxac","Capsule","Snowbrand","1S","2000-11-01"]
["21-014","Oxcarbazepine","Trileptal","Tablet","Novartis Pharms","1S","01-14-2000"]
["20-987","Pantoprazole Sodium","Protonix","Tablet","Wyeth Ayerst","1S","2000-02-02"]
["21-107","Alosetron HC1","Lotronex","Tablet","Glaxo Wellcome","1P","2000-09-02"]
["21-084","Perfluoroalkylpolyether (PFPE); Polytetrafluoroethylene (PTFE) ","Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACWA)","Paste","US Army Med Res and Material Command","1,4P","02-17-2000"]
["20-789","Zonisamide","Zonegran","Capsule","Elan Pharms","1S","03-27-2000"]
["20-971","Articaine HCl 4%; Epinephrine","Septocaine","Injectable","Deproco","1,4S","2000-03-04"]
["21-119","Verteporfin","Visudyne","Injectable","QLT PhotoTherapeutics","1P","2000-12-04"]
["20-938","Meloxicam","Mobic","Tablet","Boehringer Pharms","1S","04-13-2000"]
["21-130","Linezolid","Zyvox","Tablet","Pharmacia and Upjohn","1P","04-18-2000"]
["21-081","Insulin Glargine","Lantus","Injectable","Aventis Pharms","1S","04-20-2000"]
["20-823","Rivastigmine Tartrate","Exelon","Capsule","Novartis Pharms","1S","04-21-2000"]
["21-174","Gemtuzumab Ozogamicin","Mylotarg","Injectable","Wyeth Ayerst","1PV","05-17-2000"]
["21-176","Colesevelam HCl","Welchol","Tablet","GelTex","1S","05-26-2000"]
["20-986","Insulin Aspart Recombinant","NovoLog","Injectable","Novo Nordisk","1S","2000-07-06"]
["20-715","Triptorelin Pamoate","Trelstar Depot","Injectable","Debio Recherche","1S","06-15-2000"]
["20-883","Argatroban","Acova","Injectable","Texas Biotech","1S","06-30-2000"]
["20-484","Tinzaparin Sodium","Innohep","Injectable","Dupont Pharms","1S","07-14-2000"]
["20-610","Balsalazide Disodium`","Colazal","Capsule","Salix Pharms","1S","07-18-2000"]
["20-941","Docosanol ","Abreva","Cream","Avanir Pharm","1S","07-25-2000"]
["21-214","Unoprostone Isopropyl","Rescula","Solution","Ciba Vision","1P","2000-03-08"]
["21-197","Cetrorelix Acetate","Cetrotide","Injectable","Asta Medica","1S","2000-11-08"]
["21-226","Lopinavir;Ritonavir","Kaletra","Capsule","Abbott Labs","1,4P","09-15-2000"]
["21-248","Arsenic Trioxide","Trisenox","Injectable","Cell Therapeutics","1PV","09-25-2000"]
["20-687","Mifepristone","Mifeprex","Tablet","Population Council","1P","09-28-2000"]
["20-873","Bivalirudin","Angiomax","Injectable","The Medicines Co","1S","12-15-2000"]
["21-204","Nateglinide","Starlix","Tablet","Novartis","1S","12-22-2000"]

{"sheet":"1999","index":5,"n_rows":36,"n_cols":7,"rows_kept":36,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number","Generic Name ","Trade Name","Dosage Form","Applicant       ","Classification ","Approval Date"]
["20-863","Cilostazol","Pletal","Tablet","Otsuka Pharm","1S","01-15-1999"]
["20-886","Alitretinoin","Panretin","Topical Gel","Ligand Pharm","1-PV","1999-02-02"]
["20-955","Sodium Ferric Gluconate Complex","Ferrlicit","Injectable","R&D Labs","1P","02-18-1999"]
["21-007","Amprenavir","Agenerase","Capsule","Glaxo Wellcome","1P","04-15-1999"]
["20-766","Orlistat","Xenical","Capsule","Roche","1P","04-23-1999"]
["21-042","Rofecoxib","Vioxx","Tablet","Merck Res","1P","05-20-1999"]
["21-071","Rosiglitazone Maleate","Avandia","Tablet","SKB Pharms","1P","05-25-1999"]
["20-862","Doxercalciferol","Hectorol","Capsule","Bone Care","1S","1999-09-06"]
["21-066","Ketotifen Fumarate","Zaditor","Solution","Ciba Vision","1P","1999-02-07"]
["21-073","Pioglitazone HCl","Actos","Tablet","Takeda America","1P","07-15-1999"]
["21-036","Zanamivir","Relenza","Powder for Inhalation","Glaxo Wellcome","1P","07-26-1999"]
["21-057","Ganirelix Acetate","Antagon","Injectable","Organon","1P","07-29-1999"]
["21-012","Kit for the Prep Technetium TC 99M Depreotide","Technetium TC 99M Depreotide Kit","Injectable","Diatide","1P","1999-03-08"]
["21-029","Temozolomide","Temodar","Capsule","Schering","1PV","1999-11-08"]
["20-859","Zaleplon","Sonata","Capsule","Wyeth Ayerst Labs","1S","08-13-1999"]
["20-984","Rapacuronium Bromide","Raplon","Injection","Organon","1S","08-18-1999"]
["20-973","Rabeprazole Sodium","Aciphex","Tablet","Eisai (US)","1S","08-19-1999"]
["21-083","Sirolimus","Rapamune","Solution","Wyeth Ayerst Labs","1P","09-15-1999"]
["50-778","Epirubicin HCl","Ellence","Injectable","Pharmacia and Upjohn","1P","09-15-1999"]
["50-747","Dalfopristin/Quinupristin","Synercid","Injectable","Rhone Poulenc Rorer","1P","09-21-1999"]
["21-079","Pemirolast Potassium","Alamast","Solution","Santen","1P","09-24-1999"]
["20-931","Dofetilide","Tikosyn","Capsule","Pfizer","1S","1999-01-10"]
["20-796","Entacapone","Comtan","Tablet","Orion","1S","10-19-1999"]
["20-753","Exemestane","Aromasin","Tablet","Pharmacia & Upjohn","1SV","10-21-1999"]
["21-087","Oseltamivar Phosphate","Tamiflu","Capsule","Roche","1P","10-27-1999"]
["20-744","Poractant","Curosurf","Suspension","Dey Labs","1SV","11-18-1999"]
["21-035","Levetiracetam","Keppra","Tablet","UCP Pharma","1S","11-30-1999"]
["20-965","Aminolevulinic Acid HCl","Levulan Kerastick","Solution","Dusa","1S","1999-03-12"]
["20-937","Gadoversetamide","Optimark","Injectable","Mallinckrodt","1S","1999-08-12"]
["20-922","Mequinol; Tretinoin","Solage","Solution","Bristol Myers Squibb","1S","1999-10-12"]
["21-085","Moxifloxacin HCl","Avelox","Tablet","Bayer","1S","1999-10-12"]
["21-038","Dexmedetomidine HCl","Precedex","Injectable","Abbott Labs","1S","12-17-1999"]
["21-061","Gatifloxacin","Tequin","Tablet","Bristol Myers Squibb","1S","12-17-1999"]
["20-845","Nitric Oxide","INOmax","Gas for Inhalation","INO Thereapeutics","1PV","12-23-1999"]
["21-055","Bexarotene","Targretin","Capsule","Ligand Pharms","1PV","12-29-1999"]

{"sheet":"1998","index":6,"n_rows":31,"n_cols":7,"rows_kept":31,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["NDA Number ","Generic Name","Trade Name","Dosage Form","Applicant","*Classification","Approval Date"]
["20-697","Tolcapone","Tasmar","Tablet","Roche","1-S","01-29-1998"]
["20-763","Naratriptan Hydrochloride","Amerge","Tablet","Glaxo Wellcome","1-S","1998-10-02"]
["20-829","Montelukast Sodium","Singulair","Tablet","Merck","1-S","02-20-1998"]
["20-807","Lepirudin","Refludan","Powder","Hoechst Marion Roussel","1-PV","1998-06-03"]
["20-583","Loteprednol Etabonate","Lotemax","Ophthalmic Suspension","Bausch & Lomb","1-S","1998-09-03"]
["20-771","Tolterodine Tartrate","Detrol","Tablet","Pharmacia & Upjohn","1-S","03-25-1998"]
["20-835","Risedronate Sodium","Actonel","Tablet","Procter & Gamble","1-S","03-27-1998"]
["20-895","Sildenafil Citrate","Viagra","Tablet","Pfizer","1-P","03-27-1998"]
["20-816","Brinzolamide","Azopt","Ophthalmic Suspension","Alcon","1-S","1998-01-04"]
["20-772","Sacrosidase","Sucraid","Solution","Orphan Medical","1-PV","1998-09-04"]
["20-819","Paricalcitol","Zemplar","Injection","Abbott","1-S","04-17-1998"]
["20-896","Capecitabine","Xeloda","Tablet","Roche","1-P","04-30-1998"]
["20-912","Tirofiban Hydrochloride","Aggrastat","Injection","Merck","1-P","05-14-1998"]
["20-718","Eptifibatide","Integrilin","Injection","COR Therapeutics","1-P","05-18-1998"]
["20-838","Candesartan Cilexetil","Atacand","Tablet","Astra Merck","1-S","1998-04-06"]
["21-024","Rifapentine","Priftin","Tablet","Hoechst Marion Roussel","1-PV","06-22-1998"]
["20-864","Rizatriptan Benzoate","Maxalt","Tablet","Merck","1-S","06-29-1998"]
["20-785","Thalidomide","Thalomid","Capsule","Celgene","1-PV","07-16-1998"]
["20-822","Citalopram Hydrobromide","Celexa","Tablet","Forest Pharms","1-S","07-17-1998"]
["20-961","Fomivirsen Sodium","Vitravene","Injection","Isis Pharm","1-P","08-26-1998"]
["20-905","Leflunomide","Arava","Tablet","Quintiles","1-P","1998-10-09"]
["20-887","Technetium tc 99m Apcitide","AcuTect","Injection","Diatide","1-P","09-14-1998"]
["20-972","Efavirenz","Sustiva","Capsule","Dupont Pharm","1-P","09-17-1998"]
["20-892","Valrubicin","Valstar","Solution","Anthra Pharm","1-PV","09-25-1998"]
["20-926","Sevelamer Hydrochloride","Renagel","Capsule","GelTex Pharm","1-S","10-30-1998"]
["20-850","Telmisartan","Micardis","Tablet","Boehringer Ingelheim","1-S","1998-10-11"]
["20-898","Thyrotropin Alfa","Thyrogen","Injection","Genzyme","1-PV","11-30-1998"]
["20-977","Abacavir Sulfate","Ziagen","Tablet","Glaxo Wellcome","1-P","12-17-1998"]
["20-717","Modafinil","Provigil","Tablet","Cephalon","1-SV","12-24-1998"]
["20-998","Celecoxib","Celebrex","Capsule","Searle","1-P","12-31-1998"]

{"sheet":"NDAs","index":9,"n_rows":37,"n_cols":25,"rows_kept":37,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
[{"$nulls":9},"NDAs Approved in Calendar Years 1990-2002 by Therapeutic Potentials and Chemical Types"]
[]
[{"$nulls":4},"Therapeutic Potential - Priority Review*",{"$nulls":9},"Therapeutic Potential - Standard Review**"]
[{"$nulls":4},"and ",{"$nulls":9},"and"]
[{"$nulls":4},"Chemical Type***",{"$nulls":9},"Chemical Type***"]
[]
["Year ",1,2,3,4,5,6,7,"Total",null,1,2,3,4,5,6,7,"Total",null,"Total Approvals",null,null,"NME","Significant NME","NDA/NME%"]
[1990,12,0,8,0,0,0,0,20,null,11,2,23,2,2,4,0,44,null,64,null,null,23,12,35.9375]
[1991,14,0,5,0,0,0,0,19,null,16,1,15,2,10,0,0,44,null,63,null,null,30,14,47.61904761904761]
[1992,11,0,5,0,1,0,0,17,null,15,1,30,5,21,1,1,74,null,91,null,null,26,11,28.57142857142857]
[1993,13,0,6,0,0,0,0,19,null,12,0,18,1,18,2,0,51,null,70,null,null,25,13,35.714285714285715]
[1994,13,0,4,0,0,0,0,17,null,9,0,23,5,8,0,0,45,null,62,null,null,22,13,35.483870967741936]
[1995,9,1,5,0,0,0,0,15,null,19,5,30,2,11,0,0,67,null,82,null,null,28,9,34.146341463414636]
[1996,18,0,10,0,1,0,0,29,null,35,5,50,4,7,0,1,102,null,131,null,null,53,18,40.458015267175576]
[1997,9,1,6,1,3,0,0,20,null,30,2,52,12,4,0,1,101,null,121,null,null,39,9,32.231404958677686]
[1998,16,0,9,0,0,0,0,25,null,14,0,46,4,0,0,1,65,null,90,null,null,30,16,33.33333333333333]
[1999,19,1,7,1,0,0,0,28,null,16,2,32,3,2,0,0,55,null,83,null,null,35,19,42.168674698795186]
[2000,9,1,9,1,0,0,0,20,null,18,0,48,7,3,0,2,78,null,98,null,null,27,9,27.55102040816326]
[2001,7,1,1,0,1,0,0,10,null,17,1,23,9,5,0,1,56,null,66,null,null,24,7,36.36363636363637]
[2002,7,0,3,1,0,0,0,11,null,10,2,44,5,6,0,0,67,null,78,null,null,17,7,21.794871794871796]
[]
[]
[]
["*Priority Review "]
["Significant improvement compared to marketed products, in the treatment, diagnosis, or prevention of a disease."]
[]
["**Standard Review"]
["The drug appears to have therapeutic qualities similar to those of one or more already marketed drugs."]
[]
["***Chemical Types:"]
["     1 -   New molecular entity "]
["     2 -   New ester, new salt, or other noncovalent derivative"]
["     3 -   New formulation"]
["     4 -   New combination"]
["     5 -   New manufacturer"]
["     6 -   New indication (Beginning in 1994, Type 6's were tracked as efficacy supplements, not as NDAs.)"]
["     7 -   Drug already marketed, but without an approved NDA"]