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{"sheet":"Table S1","index":0,"n_rows":6,"n_cols":6,"rows_kept":6,"cut":false,"hidden":false,"merged":[[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S1   Physical data and yields of 2 and 3"]
["Compd","Yield     (%)","m.p.          (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+ Calcd (Found)         or Analysis         Calcd (Found)"]
["2a",75.8,"108.6-      111.6","δH (60MHz; CDCl3; Me4Si) 5.27 (2H, s, CH2), 6.82-8.03 (8H, m, Ar H)","280(M+, 11.57) 245(16.85) 139(100.00)","C14H10Cl2O2 C;59.81 (59.58) H;3.59 (3.52)"]
["2b",85.8,"105.0-107.0","δH (60MHz; CDCl3; Me4Si) 5.31 (2H, s, CH2), 6.88-7.97 (9H, m, Ar H)","290(M+, 5.47) 105(100.00)","–"]
["3a",63.8,"98.7-102.0","δH (60MHz; CDCl3; Me4Si) 7.34-8.29 (8H, m, 2-, 4-, 5-, 6- H, Phenyl H)","262(M+, 100.00)","–"]
["3b",45.9,"46.0-48.0","δH (60MHz; CDCl3; Me4Si) 7.17-7.84 (9H, m, 2-, 4-, 5-, 6- H, Phenyl H)","272(M+, 100.00)","–"]

{"sheet":"Table S2","index":1,"n_rows":19,"n_cols":6,"rows_kept":19,"cut":false,"hidden":false,"merged":[[0,0,0,5],[18,0,18,3]],"flags":["formulas_cached_only"]}
["Table S2   Physical data and yields of 5, 6 and 7"]
["Compd","Yield      (%)","m.p.     (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+  Calcd (Found)        or Analysis Calcd(Found)"]
["5a","49.2","75.4-78.0","δH (60MHz; CDCl3; Me4Si) 1.73 (3H, d, J 7.3, CH3), 4.91 (1H, q, J 6.1, CH), 6.81 (H, d, J 8.5, 3-H), 7.20 (1H, br s, COOH), 7.65 (1H, dd, J 9.8 and 2.5, 4-H), 7.95 (1H, d, J 2.5, 6-H), 10.42 (1H, s, CHO)","272(M+, 28.02), 228(30.93), 201(100.00)","C10H9BrO4 C;43.98(43.91)      H;3.32 (3.26)"]
["5b","23.0","99.7-102.5","δH (60MHz; CDCl3; Me4Si) 1.74 (3H, d, J 6.8, CH3), 4.90 (1H, q, J 13.6, CH), 6.74(1H, s, COOH), 6.84 (1H, d, J 8.8, 3-H), 7.49 (1H, dd, J 9.2 and 2.1, 4-H), 7.78 (1H, d, J 2.9, 6-H),  10.40 (1H, s, CHO)","228(M+, 21.13), 184(21.33), 155(100.00)","C10H9ClO4     C;52.53 (52.20) H;3.97 (3.91)"]
["5d","27.3","95.0-98.0","δH (60MHz; CDCl3; Me4Si) 1.78 (3H, d, J 6.8, CH3), 5.29 (1H, m, CH), 7.32-8.55 (4H, m, 3-, 4-, 6-H and COOH) 10.40 (1H, s, CHO)\n","239(M+, 11.95), 194(51.68), 166(100.00)","C10H9NO6   C;50.22 (50.16) H;3.79 (3.73) N;5.86 (6.04)"]
["5e","67.7","101.8-103.0","δH (60MHz; CDCl3; Me4Si)  1.64 (3H, d, J 7.1, CH3), 3.90 (3H, s, OCH3), 5.08 (1H, d, J 7.1, CH),  7.14-7.36 (3H, m, 4-, 5-, 6-H), 7.63 (1H, s, COOH), 10.4 (1H, s, CHO)","224(M+, 53.55), 151(100.00)","–"]
["5f",45.6,"173.8-176.4","δH (60 MHz; acetone-d6; Me4Si) 2.66 (3H, s, COCH3), 4.93 (2H, s, CH2), 7.05-7.74 (3H, m, 4-, 6-, 7-H)","272(M+, 18.42), 43(100.00)","–"]
["5g","85.9","120.5-123.3","δH (60MHz; acetone-d6; Me4Si) 2.65 (3H, s, COCH3), 4.89 (1H, s, CH2), 5.10 (1H, br s, COOH), 7.05-7.75 (4H, m, 3-, 4-, 5-, 6-H)","194(M+, 7.29), 121(100.00)","–"]
["5h",75.2,"134.8-136.7","δH (60 MHz; CDCl3; Me4Si) 1.01 (3H, t, J 7.4, CH2CH3), 3.08 (2H, q, J 7.8, CH2CH3), 4.89 (2H, s, OCH2), 7.04-7.71 (4H, m, 3-, 4-, 5-, 6-H), 7.45 (1H, brs, COOH)","208(M+, 7.65), 179(100.0)","–"]
["6a)","40.9","167.0-171.0","δH (500MHz; 3; Me4Si) 5.47 (0.37H, s, 3-H), 5.71 (0.63H, s, 3-H), 7.00 (0.37H, d, J 8.7, 7-H), 7.04 (0.63H, d, J 8.7, 7-H), 7.25-7.40 (5H, m, 4-, 6-H, Phenyl H), 7.65-7.71 (2H, m, Phenyl H)","290(M+, 16.35), 228(100.00), 167(43.43)","–"]
["7a","71.1","oil","δH (60MHz; CDCl3; Me4Si)  2.44 (3H, s, CH3), 6.31 (1H, s, 3-H), 7.26-7.58 (3H, m, 4-, 6-, 7-H)","210(M+, 100.00), 131(32.46) ","–"]
["7b","47.0","oil","δH (60MHz; CDCl3; Me4Si)  2.43 (3H, s, CH3), 6.29 (1H, s, 3-H), 7.24-7.40 (3H, m, 4-, 6-, 7-H)","166(M+, 100.00), 131(20.63)","–"]
["7c","98.6","143.5-147.0","δH (60MHz; CDCl3; Me4Si)   6.52 (1H, s, 3-H), 7.28-7.85 (8H, m, 4-, 6-, 7-H and Phenyl H)","228(M+, 100.00), 165(31.41)","–"]
["7d","39.1","93.0-95.0","δH (60MHz; CDCl3; Me4Si)  2.54 (3H, s, CH3), 6.52 (1H, s, 3-H), 7.25-8.38 (3H, m, 4-, 6-,7-H)","177(M+, 100.00), 131(46.94)","C9H7NO3     C;61.02 (61.03) H;3.98 (3.92) N;7.91 (7.91)"]
["7e","71.5","oil","δH (60MHz; CDCl3; Me4Si)  2.44 (3H, s, CH3), 3.97 (3H, s, OCH3),  6.33-7.10 (4H, m, 3-, 4-, 5-, 6-H)","162(M+, 100.00), 147(18.36)","–"]
["7f",99.4,"oil","–","210(M+, 100.00)","–"]
["7g","67.9","oil","δH (60MHz; CDCl3; Me4Si)  2.23 (3H, s, CH3), 7.24-7.40 (5H, m, 2-, 4-, 5-, 6-, 7-H)","132(M+, 100.00), "]
["7h",85,"oil","δH (60 MHz; CDCl3; Me4Si) 1.32 (3H, t, J 7.3, CH2CH3), 2.65 (2H, q, J 7.6, CH2CH3), 7.25-7.49 (4H, m, 2-, 4-, 5-, 6-, 7-H)","146(M+, 30.04), 131(100.00)","–"]
["a) mixture of diastereoisomers"]

{"sheet":"Table S3","index":2,"n_rows":19,"n_cols":7,"rows_kept":19,"cut":false,"hidden":false,"merged":[[0,0,0,5],[18,0,19,6]],"flags":["formulas_cached_only"]}
["Table S3   Physical data and yields of 8, 9, 10 and 11"]
["Compd","Yield     (%)","m.p.          (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+ Calcd (Found)         or Analysis         Calcd (Found)","E / Z"]
["8a","39.0","145.6-146.8","δH (60MHz; CDCl3; Me4Si) 2.63 (3H, s, CH3), 7.27-7.50 (7H, m, 4-, 5-, 6-H, Phenyl H)","304(M+, 100.00) 289(77.99) 254(22.06)","C16H10Cl2O2 C;62.97 (62.83) H;3.30 (3.18)","–"]
["8b","53.4","120.2-123.1","δH (60MHz; CDCl3; Me4Si) 1.25 (3H, t, J 7.08, CH2CH3), 2.72 (2H, t, J 6.4, CHCH2), 3.41 (2H, t, J 6.4, CH2CH2), 4.16 (2H, q, J 7.1, CH2CH3), 7.27-7.50 (7H, m, 4-, 5-, 6-H and Phenyl H)","390(M+, 80.39), 289(100.00)","–","–"]
["8c",50.3,"74.5-77.5","δH (60 MHz; CDCl3; Me4Si) 1.24 (3H, t, J 7.0, CH2CH3), 2.71 (2H, t,  J 6.6, CH2CH2), 3.38 (2H, t, J 6.6, CH2CH2), 4.15 (2H, q, J 7.1, CH2CH3), 7.15-7.52 (8H, m, 4-, 5-, 6-H, Phenyl H)","400(M+, 61.69), 299(100.00)","C20H17BrO4 400.0310    (400.0310)","–"]
["8d",53.9,"99.9-102.5","δH (60 MHz; CDCl3; Me4Si) 2.58 (3H, s, CH3), 2.58 (3H, s, CH3), 7.28-7.77 (3H, m, 4-, 6-, 7-H)","252(M+, 73.30), 237(100.00)","–","–"]
["(E)-9a",8.4,"173.2-176.0","δH (400MHz; acetone-d6; Me4Si) 2.33 (3H, d, J 1.5, CCH3=CH), 2.75-2.78 (2H, m, NCH2CH2), 3.46-3.51 (2H, m, NCH2CH2), 3.77 (3H, s, OCH3), 3.80 (3H, s, OCH3), 6.57 (1H, q, J 1.5, CCH3=CH), 6.74 (1H, dd, J 8.1 and 1.8, 6'-H), 6.85 (1H, d, J 8.1, 5'-H), 6.85 (1H, d, J 1.8, 2'-H), 7.28 (1H, t, J 7.7, 5-H), 7.36 (1H, dd, J 7.5 and 1.3,  6-H), 7.45 (1H, dd, J 7.6 and 1.1, 4-H ), 7.56-7.59 (4H, m, Phenyl H)","509 (M+, 9.69)  370 (25.64)       164 (100.00) ","C28H25Cl2NO4 C;65.89 (65.80) H;4.94 (4.93)  N;2.74 (2.73) ","90 / 10"]
["(E)-9b",34.8,"136.9-139.2","δH (500MHz; CDCl3; Me4Si) 1.05 (3H, t, J 7.1, CH2CH3), 1.15 (3H, t, J 7.1, CH2CH3), 2.17 (3H, d, J 1.4, CH3), 3.22 (2H, q, J 7.3, CH2CH3), 3.42 (2H, q, J 7.8, CH2CH3), 6.60 (1H, q, J 1.4, CCH3=CH), 7.15 (1H, dd, J 7.8, 5-H), 7.22 (1H, dd, J 7.8 and 0.9, 6-H), 7.33 (1H, dd, J 7.6 and 1.2, 4-H), 7.36-7.39 (2H, m, Phenyl H), 7.44-7.47(2H, m, Phenyl H)","401(M+, 63.46), 329(100.00), 266(29.96)","C22H21Cl2NO2 C;65.68 (65.54) H;5.26 (5.22)  N;3.48 (3.48)","87 / 13"]
["(E)-9c",19.1,"112.9-114.0","δH (400MHz; CDCl3; Me4Si) 2.13 (3H, d, J 1.4, CCH3=CH), 3.38-3.67 (8H, m, NCH2CH2O×2), 6.59 (1H, q, J 1.5, CCH3=CH), 7.16 (1H, t, J 7.7, 5-H), 7.22 (1H, dd, J 8.5 and 1.1, 6-H), 7.33 (1H, dd, J 7.7 and 1.1, 4-H), 7.36-7.38 (2H, m, Phenyl H), 7.45-7.47(2H, m, Phenyl H)\n","415 (M+, 53.28), 329(100.00), 301(13.27), 266(26.10)","C22H19Cl2NO3 C;63.47 (63.40) H;4.60 (4.55)  N;3.36 (3.38) ","82 / 18"]
["(E)-9d",46,"168.9-170.0","δH (400MHz; CDCl3; Me4Si) 2.34 (3H, s, CCH3=CH), 3.80 (3H, s, OCH3), 6.61 (H, s, CCH3=CH), 6.85-6.88 (2H, m, phenyl H), 7.17 (1H, t, J 7.7, 5-H), 7.23 (1H, br s, NH), 7.22-7.51 (8H, m, Phenyl H)\n","451 (M+, 100.00), 436 (85.85)","C25H19Cl2NO3 C;66.38 (66.20) H;4.23 (4.11)  N;3.10 (3.06)","–"]
["(E)-9e","11.2","123.3-125.3","δH (400MHz; CDCl3; Me4Si) 1.17 (3H, t, J 7.1, CH2CH3), 2.48 (2H, t, J 7.3, CH2CH2), 2.82 (2H, t, J 7.1, NHCH2CH2), 3.09 (2H, t, J 7.3, CH2CH2), 3.55-3.61 (2H, m, NHCH2CH2), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 4.02 (2H, q, J 7.0, CH2CH3), 6.22 (1H, s, C=CH), 6.39 (1H, br t, J 5.5, NH), 6.72-6.74 (2H, m,  2'- and 5'-H), 6.80-6.82 (1H, m, 6'-H), 7.17 (1H, t, J 7.9, 5-H), 7.27 (1H, dd, J 7.7 and 1.1, 6-H), 7.35 (1H, dd, J 7.7 and 1.1, 4-H), 7.34-7.37 (2H, m, Phenyl H), 7.42-7.45(2H, m, Phenyl H)","595(M+, 5.37), 164(100.00)","C32H31Cl2NO6  C;64.43 (64.43)      H; 5.24 (5.30)        N; 2.35 (2.36)","66 / 34"]
["(E)-9fa)","42.2 b)","oil b)","δH (500MHz; CDCl3; Me4Si) 1.18 (3H, t, J 6.9, CH2CH3), 2.54 (2H, t, J 7.8, CH2CH2), 3.05 (2H, t, J 7.6, CH2CH2), 3.19-1.67 (8H, m, OCH2CH2N×2), 4.04 (2H, q, J 7.4, CH2CH3), 6.39 (1H, s, C=CH), 7.17 (1H, t, J 7.8, 5-H), 7.25 (1H, dd, J 7.0 and 1.2, 6-H), 7.34-7.54 (5H, m, 4-H and Phenyl H)  \n","501(M+, 100.00), 343(66.66)b)","C26H25Cl2NO5   501.1110  (501.1107)b)","67 / 33"]
["(Z)-9fa)","-","-","δH (500MHz; CDCl3; Me4Si) 1.26 (3H, t, J 7.4, CH2CH3), 2.38 (2H, t, J 7.1, CH2CH2), 2.64 (2H, t, J 6.9, CH2CH2), 3.19-1.67 (8H, m, OCH2CH2N×2), 4.12 (2H, CH2CH3), 6.29 (1H, s, CCH3=CH), 7.17 (1H, t, J 7.8, 5-H), 7.25 (1H, dd, J 7.0 and 1.2-, 6-H), 7.34-7.54 (5H, m, 4-H and Phenyl H)      \n","-","-"]
["(E)-9g",42,"60.1-62.0","δH (400 MHz; CDCl3; Me4Si) 1.21 (3H, t, J 7.2, CH2CH3×2), 2.35 (3H, d, J 1.1, CCH3=CH), 2.37 (3H, s, CH3), 3.42 (2H, q, J 7.3, CH2CH3), 3.49 (2H, q, J 7.3, CH2CH3), 6.58 (1H, d, J 1.1, CCH3=CH), 7.27 (1H, d,  J 9.2, 7-H), 7.37 (1H, dd,  J 8.4 and 2.2, 6-H), 7.61 (1H, d,  J 1.5, 4-H)","349(M+, 54.08), 279(100.00)","C17H20BrNO2 349.0677　 （349.0678)","–"]
["(Z)-9g",4,"oil","δH (400 MHz; CDCl3; Me4Si) 1.05 (3H, t, J 7.3, CH2CH3), 1.15 (3H, t, J 7.0, CH2CH3), 2.22 (3H, s, CH3), 2.24 (3H, d, J 1.5, CCH3=CH), 3.33 (2H, q, J 7.3, CH2CH3), 3.41 (2H, q, J 7.3, CH2CH3), 6.08 (1H, d, J 1.5, CCH3=CH), 7.20 (1H, d,  J 8.4, 7-H), 7.33 (1H, dd,  J 8.4 and 1.8, 6-H), 7.57 (1H, d,  J 1.5, 4-H)","349(M+, 59.26), 277(100.00)","C17H20BrNO2 349.0677　 （349.0670)","–"]
[10,68.8,"oil","δH (60 MHz; CDCl3; Me4Si) 1.24 (3H, t, J 7.3, CH2CH3), 2.67 (2H, q, J 7.3, CH2CH3), 7.00-7.60 (4H, m, 4-, 5-, 6-, 7-H)","226(44.12), 224(M+, 44.12), 102(100.00)\n","–"]
["(E)-11a",88.6,"oil","δH (400 MHz; CDCl3; Me4Si) 1.30 (3H, t, J 7.3, CH2CH3), 2.38 (3H, d, J 1.5, CCH3=CH), 2.90 (2H, q, J 7.4, CH2CH3), 3.56-3.78 (8H, m, NCH2CH2O×2), 6.56 (1H, d, J 1.1, CCH3=CH), 7.20-7.33 (2H, m, 5-, 6-H), 7.39-7.43 (1H, m, 7-H), 7.52-7.54 (1H, m, 4-H)","299(M+, 58.22), 213(100.00)","C18H21NO3 299.1521 (299.1518)"]
["(E)-11b",46.4,"131.0-135.0","δH (400 MHz; CDCl3; Me4Si) 1.29 (3H, t, J 7.3, CH2CH3), 2.63 (3H, d, J 1.5, CCH3=CH), 2.84 (2H, t, J 7.0, NCH2CH2), 2.90 (2H, q, J 7.3, CH2CH3), 3.61 (2H, m, NCH2CH2), 3.87 (3H, s, OCH3), 3.88 (3H, s, OCH3), 5.60 (1H, t, J 5.5, NHCH2CH2), 6.27 (1H, d, J 1.1, CCH3=CH), 6.76-6.78 (2H, m, 2'-, 6'-H), 6.83 (1H, d, J 8.4, 5'-H) 7.20-7.31 (2H, m, 5-, 6-H), 7.39 (1H, d, J 8.4, 7-H), 7.53 (1H, d, J 7.7, 4-H)","393(M+, 12.86), 164(100.00)","C24H27NO4\nC;73.26 (72.99)\nH;6.92 (7.06)\nN;3.56 (3.58)"]
[" a) Assigned using 1H-NMR of  mixture of  (E)- and (Z)- isomers. b) Mixture of (E)- and (Z)- isomers."]

{"sheet":"Table S4","index":3,"n_rows":7,"n_cols":7,"rows_kept":7,"cut":false,"hidden":false,"merged":[[6,0,6,6],[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S4   Physical data and yields of 12 and 13"]
["Compd","Yield (%)","m.p.    (℃)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+ Calcd (Founf)          or Analysis         Calcd (found)","E /Z"]
[12,"46.7","41.0-43.9","δH (60MHz; CDCl3; Me4Si)  4.03 (3H, s, OCH3),  7.04-7.53 (4H, m, 3-, 4-, 5-, 6-H), 9.91 (1H, s, CHO)","176(M+, 100.00), 161(21.32)","–"]
["(E)-13a","73.8","121.5-123.0","δH (400MHz; CDCl3; Me4Si) 2.83 (2H, t, J 7.0, NHCH2CH2), 3.65 (2H, m, NHCH2CH2), 3.87 (3H, s, OCH3), 3.88 (3H, s, OCH3), 4.01 (3H, s, OCH3), 5.59 (1H, br, NH), 6.54 (1H, d, J 15.4, CH=CH), 6.74-6.77 (2H, m, Ar H), 6.83-6.85 (2H, m, Ar H), 6.86 (1H, s, 3-H), 7.12-7.17 (2H, m, Ar H), 7.51 (1H, d, J 15.6, CH=CH)","381(M+, 14.37), 164(100.00)","C22H23NO5   C;69.28 (69.05)      H; 6.08 (6.12)        N; 3.67 (3.64)",">99 / 1"]
["(E)-13b","63.8","86.6-88.7","δH (400MHz; CDCl3; Me4Si) 1.22-1.27 (6H, m, CH2CH3 ×2), 3.51 (4H, q, J 6.9, CH2CH3 ×2), 4.03 (3H, s, OCH3), 6.85 (1H, m, Ar H), 6.86 (1H, s, 3-H), 7.02 (1H, d, J 15.0, CH=CH), 7.13-7.18 (2H, m, Ar H), 7.59 (1H, d, J 15.1, CH=CH)","273(M+, 46.62), 201(100.00)","C16H19NO3   C;70.31 (70.29)      H; 7.01 (7.24)        N; 5.12 (5.07)","78 / 22"]
["(E)-13c","59.2","99.8-102.4","δH (400MHz; CDCl3; Me4Si) 3.73 (8H, m, Morpholine H), 4.02 (3H, s, OCH3), 6.86 (1H, m, Ar H), 6.88 (1H, s, 3-H), 7.07 (1H, d, J 15.0, CH=CH), 7.14-7.20 (2H, m, Ar H), 7.59 (1H, d, J 15.0, CH=CH)","287(M+, 48.93), 201(100.00)","C16H17NO4   C;66.89 (66.80)      H; 5.96 (6.08)        N; 4.88 (4.78)",">99 / 1"]
["a) Assigned using 1H-NMR of  mixture of  (E)- and (Z)- isomers. b) Mixture of (E)- and (Z)- isomers."]

{"sheet":"Table S5","index":4,"n_rows":25,"n_cols":7,"rows_kept":25,"cut":false,"hidden":false,"merged":[[24,0,24,6],[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S5   Physical data and yields of 14 and 15"]
["Compd","Yield     (%)","m.p.          (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+ Calcd (Found)         or Analysis         Calcd (Found)","E / Z"]
["14a","68.6","183.5-185.5","δH (60MHz; CDCl3; Me4Si)  7.30- 8.09 (8H, m, Ar-H)","334(M+, 69.26), 139(100.00)","C15H8BrClO2 C;53.69 (53.54) H;2.40 (2.27) "]
["14b","14.1","139.8-142.0","δH (60MHz; CDCl3; Me4Si) 3.90 (3H, s, OCH3), 6.68- 8.18 (8H, m, Ar H)","330(M+, 30.02), 135(100.00)","–"]
["14c","71.0","49.0-52.2","δH (60MHz; CDCl3; Me4Si) 3.89 (3H, s, OCH3), 4.03 (3H, s, OCH3), 6.93-8.24 (8H, m, Ar H)","282(M+, 100.00), 135(75.52)","–"]
["14d","15.7","79.0-82.2","δH (60MHz; CDCl3; Me4Si) 4.04 (3H, s, OCH3), 6.88-8.16 (8H, m, Ar H)","286(M+, 100.00), 139(28.50)","–"]
["14e","26.3","212.2-217.5","δH (60MHz; acetone-d6; Me4Si)  7.11-8.20 (8H, m, Ar H), 9.23 (1H, s, OH)","272(M+, 100.00), 139(62.44)","–"]
["14f","71.4","oil","δH (60MHz; CDCl3; Me4Si)  1.76 (3H, d, J 6.4, CHCH3), 5.61 (1H, q, J 5.9, CHCH3), 6.79-8.17 (13H, m, Ar H)","376(M+, 46.81), 105(100.00)","–"]
["(Z)-15a","53.5","160.1-162.0","δH (400MHz; DOSO-d6; Me4Si)  3.71 (3H, s, OCH3),  6.65 (1H, ddd, J 8.3, 2.6 and 1.1, 4'-H or 6'-H), 6.69 (1H, s, C=CH), 7.05 (1H, s, 3-H), 7.14 (1H, d, J 8.7, 4'-H or 6'-H), 7.21 (1H, dd, J 8.1, 5'-H), 7.28 (1H, m, 2'-H), 7.45-7.54 (4H, m, Phenyl H), 7.45-7.46 (2H, m, 6-, 7-H), 7.89-7.90 (1H, m, 4-H), 10.29 (1H, br s, NH)","481(M+, 5.46), 361(100.00)","C24H17BrClNO3 C;59.71 (59.75) H;3.55 (3.55) N;2.90 (2.85)","25 / 75"]
["(Z)-15b","31.3","106.7-109.8","δH (500MHz; CDCl3; Me4Si)  1.08 (3H, t, J 7.2 CH2CH3), 1.27 (3H, t, J 6.9,  CH2CH3), 3.39 (2H, q, J 7.4, CH2CH3), 3.52 (2H, q, J 7.4, CH2CH3), 6.26 (1H, s, C=CH),  6.63 (1H, s, 3-H),  7.25-7.27 (2H, m, 6-, 7-H), 7.38-7.39 (4H, m, Phenyl H), 7.64 (1H, d, J 1.8, 4-H)","431(M+, 54.93), 361(100.00)","C21H19BrClNO2 C;58.29 (58.29) H;4.43 (4.43) N;3.24 (3.19)","20 / 80"]
["(Z)-15c","31.3","150.0-153.5","δH (500MHz; CDCl3; Me4Si)  3.47-3.77 (8H, m, NCH2CH2O×2), 6.22 (1H, s, C=CH),  6.62 (1H, d, J 0.9, 3-H),  7.31 (1H, d, J 8.7, 7-H), 7.39 (4H, m, Phenyl H), 7.41 (1H, dd, J 8.8 and 2.2, 6-H ), 7.67 (1H, d, J 1.8, 4-H)","445(M+, 32.51), 361(100.00)","C21H17BrClNO3 C;56.46 (56.27) H;3.84 (3.79) N;3.14 (3.10)","31 / 69"]
["(Z)-15da)     ","37.5b)","111.2-117.0b)","δH (400MHz; CDCl3; Me4Si) 2.72 (2H, t, J 7.2, NHCH2CH2), 3.53-3.58 (2H, m, NHCH2CH2), 3.80 (3H, s, OCH3), 3.84 (6H, s, OCH3×2), 5.68 (1H, br t, J 5.5,  NH), 6.22 (1H, s, C=CH), 6.54-7.41 (10H, m, Ar H), 7.67 (1H, d, J 1.8, 4-H)         ","535(M+, 2.80), 164(100.00)b)","C28H26BrNO5 C;62.69 (62.63) H;4.89 (4.89) N;2.61 (2.56)b)","30 / 70"]
["(E)-15da)","-","-","δH (400MHz; CDCl3; Me4Si) 2.57 (2H, t, J 7.1, NHCH2CH2), 3.38-3.43 (2H, m, NHCH2CH2), 3.85 (3H, s, OCH3), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 5.31 (1H, br t, J 5.3,  NH), 6.29 (1H, s, C=CH), 6.54-7.41 (10H, m, Ar H), 7.56 (1H, d, J 1.2, 4-H)","-","-"]
["(Z)-15e","23.6","136.4-138.5","δH (400MHz; DMSO-d6; Me4Si)  3.71 (3H, s, OCH3),  3.81 (3H, s, OCH3), 5.52-6.62 (1H, m, 4'-H or 6'-H), 6.63 (1H, s, C=CH), 6.98 (1H, s, 3-H), 7.00-7.03 (2H, m, Phenyl H), 7.12 (1H, d, J 8.5, 4'-H or 6'-H), 7.20 (1H, dd, J 8.1, 5'-H), 7.26-7.29 (1H, m, 2'-H), 7.35-7.39 (2H, m, Phenyl H), 7.44 (1H, dd, J 8.8 and 1.9, 6-H), 7.47 (1H, d, J 8.5, 7-H), 7.88 (1H, m, 4-H), 10.2 (1H, br s, NH)","477(M+, 8.33), 355(100.00)","C25H20BrNO4 C;62.77 (62.62) H;4.21 (4.14) N;2.93 (2.89)","7 / 93"]
["(Z)-15f","51.3","93.5-96.0","δH (400MHz; CDCl3; Me4Si)  1.07 (3H, t, J 7.2 CH2CH3) 1.26 (3H, t, J 7.2, CH2CH3), 3.40 (2H, q, J 7.3, CH2CH3), 3.51 (2H, q, J 7.0, CH2CH3), 3.85 (3H, s, OCH3), 6.23 (1H, s, C=CH),  6.63 (1H, s, 3-H),  6.92-6.94 (2H, m, 3'-, 5'-H), 7.26 (1H, d, J 8.8, 7-H), 7.35-7.40 (3H, m, 2'-, 6'-H, 6-H), 7.64 (1H, d, J 1.8, 4-H)","427(M+, 54.05), 357(100.00)","C22H22BrNO3 C;61.69 (61.91) H;5.18 (5.29) N;3.27 (3.21)","Z ≈ 100"]
["(Z)-15g","43.3","158.2-160.1","δH (400MHz; CDCl3; Me4Si) 3.49-3.72 (8H, m, NCH2CH2O×2), 3.86 (3H, s, OCH3), 6.19 (1H, s, C=CH),  6.64 (1H, d, J 1.1, 3-H),  6.92-6.95 (2H, m, Phenyl H), 7.31 (1H, d, J 8.8, 7-H), 7.37-7.40 (2H, m, Phenyl H), 7.41 (1H, dd, J 8.8 and 2.2, 6-H), 7.67 (1H, J 1.4, 4-H)","441(M+, 53.08), 357(100.00)","C22H20BrNO4 C;59.74 (59.67) H;4.56 (4.52) N;3.17 (3.17)","12 / 88"]
["(Z)-15ha)","30.2b)","69.2-74.0b)","δH (400MHz; CDCl3; Me4Si) 2.74 (2H, t, J 7.2, NHCH2CH2), 3.56 (2H, m, NHCH2CH2), 3.77 (3H, s, OCH3), 3.82 (3H, s, OCH3), 3.83 (3H, s, OCH3), 3.95 (3H, s, OCH3), 5.87 (1H, br t, J 5.5,  NH), 6.20 (1H, s, C=CH), 6.57-7.34 (11H, m, Ar-H)","487(M+, 10.32), 164(100.00)b)","C29H29NO6 487.1995 (487.1994)b)","35 / 65"]
["(E)-15ha)","-","-","δH (400MHz; CDCl3; Me4Si) 2.59 (2H, t, J 7.0, NHCH2CH2), 3.34 (2H, m, NHCH2CH2), 3.84 (3H, s, OCH3), 3.85 (6H, s, OCH3), 3.87 (3H, s, OCH3), 5.35 (1H, br t, J 5.3, NH), 6.34 (1H, s, C=CH), 6.57-7.34 (11H, m, Ar-H)       ","-","-"]
["(Z)-15i","56.6","159.1-162.0","δH (500MHz; CDCl3; Me4Si)  3.78 (3H, s, OCH3),  3.85 (3H, s, OCH3), 3.91 (3H, s, OCH3),  6.33 (1H, s, C=CH), 6.75-6.92 (6H, m, Ar-H), 7.12-7.17 (2H, m, Ar-H), 7.37-7.42 (4H, m, Ar-H), 7.72 (1H, br s, NH)","429(M+, 18.40), 307(100.00)","C26H23NO5 429.1576 (429.1579)","38 / 62"]
["(Z)-15ja)","58.2b)","oilb)","δH (500MHz; CDCl3; Me4Si)  1.10 (3H, t, J 7.1 CH2CH3) 1.24 (3H, t, J 7.1, CH2CH3), 3.43 (2H, q, J 7.3, CH2CH3), 3.51 (2H, q, J 7.4, CH2CH3), 3.85 (3H, s, OCH3), 3.94 (3H, s, OCH3), 6.22 (1H, s, C=CH),  6.69 (1H, s, 3-H),  6.76-6.80 (1H, m, benzofuran H), 6.91-6.93 (2H, m, Phenyl H), 7.09-7.13 (2H, m, benzofuran H), 7.39-7.41 (2H, m, Phenyl H)                        ","379(M+, 50.69), 307(100.00)b)","C23H25NO4 379.1784 (379.1786)b)","21 / 79"]
["(E)-15ja)","-","-","δH (500MHz; CDCl3; Me4Si)  0.96 (3H, t, J 7.1 CH2CH3) 0.99 (3H, t, J 7.1, CH2CH3), 3.28 (2H, q, J 7.4, CH2CH3), 3.33 (2H, q, J 7.3, CH2CH3), 3.83 (3H, s, OCH3), 4.04 (3H, s, OCH3), 6.44 (1H, s, C=CH),  6.83 -7.13 (6H, m, 3-, 4-, 5-, 6-H, Phenyl H), 7.36-7.38 (2H, m, Phenyl H)     ","-","-"]
["(Z)-15ka)","60.9b)","oilb)","δH (400MHz; CDCl3; Me4Si)  3.48-3.82 (4H, m, NCH2CH2O×2), 3.85 (3H, s, OCH3), 3.98 (3H, s, OCH3), 6.14 (1H, s, C=CH),  6.64 (1H, s,  3-H),  6.80-7.15 (5H, m, 4-, 5-, 6-H, Phenyl H), 7.01-7.45 (2H, m, Phenyl H)   ","393(M+, 45.61), 307(100.00)b)","C23H23NO5 393.1576 (393.1578)b)","20 / 80"]
["(E)-15ka)","-","-","δH (400MHz; CDCl3; Me4Si)  3.15-3.29 (8H, m, NCH2CH2O×2), 3.85 (3H, s, OCH3), 4.04 (3H, s, OCH3), 6.49 (1H, s, C=CH), 6.91-7.15 (6H, m, 3-, 4-, 5-, 6-H and Phenyl H), 7.37-7.39 (2H, m, Phenyl-H)   ","-","-"]
["(Z)-15l","57.9","oil","δH (400MHz; CDCl3; Me4Si)  1.14 (3H, t, J 7.2 CH2CH3), 1.22 (3H, t, J 7.2,  CH2CH3), 1.68 (3H, d, J 6.6, CH(CH3)), 3.45-3.60 (4H, m, CH2CH3×2), 5.53 (1H, q, J 6.6, CH(CH3)), 6.26 (1H, s, C=CH), 6.64 (1H, s, 3-H),  6.67 (1H, dd, J 8.0 and 1.1, 6-H), 6.95 (1H, dd, J 7.9, 5-H), 7.03 (1H, dd, J 7.7 and 1.1, 4-H), 7.23-7.44 (9H, Pheny H)","473(M+, 6.94), 369(100.00)","C29H28ClNO3  473.1758 (473.1756)","39 / 61"]
["a) Assigned using 1H-NMR of  mixture of  (E)- and (Z)- isomers. b) Mixture of (E)- and (Z)- isomers."]

{"sheet":"Table S6","index":5,"n_rows":22,"n_cols":6,"rows_kept":22,"cut":false,"hidden":false,"merged":[[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S6   Physical data and yields of 17, 18 and 19"]
["Compd","Yield      (%)","m.p.     (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+  Calcd (Found)        or Analysis Calcd(Found)"]
["(E)-17a",56.48,"140.9-143.6","δH (400 MHz; CDCl3; Me4Si) 1.16 (3H, t, J 7.3, CH2CH3), 1.20 (3H, t, J 7.3 CH2CH3), 2.32 (3H, d, J 1.5, CCH3=CH), 2.52 (3H, s, COCH3), 3.37 (2H, q,  J 7.3, CH2CH3), 3.48 (2H, q, J 7.3, CH2CH3), 4.02 (3H, s, OCH3), 6.04 (2H, br s, NH2), 6.10 (1H, q, J 1.5, CCH3=CH), 6.91 (1H, d, J 8.5, 6-H), 6.96 (1H, d, J 8.0, 5-H)","344(30.17)    244(M+, 100.00)","C19H24N2O4     344.1736     (344.1736)"]
["(E)-17b",20.5,"186.6-189.1","δH (400 MHz; CDCl3; Me4Si) 2.34 (3H, d, J 1.1, CCH3=CH), 2.52 (3H, s, COCH3), 3.51-3.74 (8H, m,  NCH2CH2O×2), 4.02 (3H, s, OCH3), 5.97 (2H, br s, NH2), 6.07 (1H, q, J 1.1, CCH3=CH), 6.91 (1H, d, J 8.1, 6-H), 6.97 (1H, d, J 8.0, 5-H)","358(M+, 23.33), 244(100.00)\n","C19H22N2O5\nC;63.67 (63.60)\nH;6.19 (6.25)\nN;7.82 (7.75)"]
["(E)-17c",29.2,"176.4-177.7","δH (500 MHz; CDCl3; Me4Si) 2.51 (3H, s, COCH3), 2.60 (3H, d, J 1.4, CCH3=CH), 2.81 (2H, t, J 6.8, NCH2CH2), 3.60 (2H, m, NCH2CH2), 3.86 (3H, s, OCH3), 3.86 (3H, s, OCH3), 4.01 (3H, s, OCH3), 5.55 (1H, br t, J 5.6, NHCH2CH2), 5.72 (2H, br s, NH2), 5.74 (1H, q, J 1.4, CCH3=CH), 6.73-6.75 (2H, m, 2'-, 6'-H), 6.81 (1H, d, J 8.7, 5'-H), 6.91 (1H, d, J 8.3, 6-H), 6.97 (1H, d, J 8.3, 5-H)","452(M+, 17.77), 244(100.00)\n","C25H28N2O6\nC;66.36 (66.16)\nH;6.24 (6.30)\nN;6.19 (6.23)"]
["(E)-17d",30.2,"147.1-148.9","δH (400 MHz; CDCl3; Me4Si) 1.17 (3H, t, J 6.9, CH2CH3), 1.21 (3H, t, J 7.3, CH2CH3), 2.16 (3H, s, COCH3), 2.34 (3H, d, J 1.1, CCH3=CH), 3.38 (2H, q,  J 7.0, CH2CH3), 3.49 (2H, q, J 7.4, CH2CH3), 4.01 (3H, s, OCH3), 6.14 (1H, q, J 1.1, CCH3=CH), 6.55 (2H, br s, NH2), 6.94 (1H, d, J 8.1, 6-H), 6.99 (1H, d, J 8.1, 5-H), 7.47-7.51 (2H, m, Phenyl H), 8.19-8.23 (2H, m, Phenyl H)","440(M+, 18.19), 340(100.00)","C24H25ClN2O4\nC;65.38 (65.45)\nH;5.71 (5.76)\nN;6.35 (6.27)"]
["(E)-17e",7.8,"195.7-196.8","δH (500 MHz; CDCl3; Me4Si) 2.36 (3H, d, J 1.4, CCH3=CH), 3.53-3.75 (8H, m,  NCH2CH2O×2), 4.01 (3H, s, OCH3), 6.11 (1H, d, J 1.4, CCH3=CH), 6.45 (2H, br s, NH2), 6.94 (1H, d, J 8.2, 6-H), 6.70 (1H, d, J 7.8, 5-H), 7.47-7.51 (2H, m, 2'-H, Phenyl H), 8.19-8.23 (2H, m, Phenyl H)","454(M+, 15.87) 340(100.00)\n","C24H23ClN2O5\nC;63.37 (63.34)\nH;5.10 (5.09)\nN;6.16 (6.10)"]
["(E)-17f",13.7,"180.6-182.0","δH (500 MHz; CDCl3; Me4Si) 2.62 (3H, d, J 1.4, CCH3=CH), 2.83 (2H, t, J 6.8, NCH2CH2), 3.61 (2H, m, NCH2CH2), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 4.01 (3H, s, OCH3), 5.55 (1H, br t, J 5.9, NHCH2CH2), 5.78 (1H, d, J 1.4, CCH3=CH), 6.20 (2H, br s, NH2), 6.73-6.75 (2H, m, 2'-, 6'-H), 6.82 (1H, d, J 8.7, 5'-H), 6.93 (1H, d, J 8.2, 6-H), 6.99 (1H, d, J 8.3, 5-H), 7.48-7.51 (2H, m, Phenyl H), 8.19-8.22 (2H, m, Phenyl H)","548(M+, 8.68)  164(100.00)\n","C30H29ClN2O6                 ·½CH3OH\nC;64.83 (64.97)\nH;5.53 (5.40)\nN;4.96 (5.02)"]
["18a",73,"235.3-237.4","δH (60 MHz; CDCl3; Me4Si) 2.25 (3H, s, COCH3), 2.59 (3H, s, COCH3), 4.02 (3H, s, OCH3), 6.88 (1H, d,  J 8.4, 6-H), 7.37 (1H, d, J 8.5, 5-H), 8.49 (1H, br s, NH)","325(M+, 20.88), 283(100.00)","C13H12BrNO4\nC;47.87 (47.86)\nH;3.71 (3.70)\nN;4.29 (4.26)"]
["18b",58.3,"136.0-138.4","δH (60 MHz; acetone-d6; Me4Si) 1.37 (9H, s, C(CH3)3), 2.52 (3H, s, COCH3), 4.03 (3H, s, OCH3), 6.80-7.50 (2H, m, 5-, 6-H), 8.56 (1H, br s, NH)","367(M+, 13.64), 288(100.00)","–"]
["18c",85.9,"152.9-156.8","δH (500 MHz; CDCl3; Me4Si) 1.27 (3H, t, J 7.4, CH2CH3), 2.60 (3H, s, COCH3), 2.77-2.82 (4H, m, CH2CH2), 4.00 (3H, s, OCH3), 4.17 (2H, q, J 7.4, CH2CH3), 6.81 (1H, d,  J 8.3, 6-H), 7.34 (1H, d, J 8.7, 5-H), 8.02 (1H, br s, NH)","411(M+, 11.19), 283(100.00)","C17H18BrNO6\nC;49.53 (49.30)\nH;4.40 (4.41)\nN;3.40 (3.40)"]
["18d",37,"197.7-199.3","δH (400 MHz; CDCl3; Me4Si) 1.67 (3H, d, J 7.4, CHCH3), 2.56 (3H, s, COCH3), 3.85 (1H, q, J 7.4, CHCH3), 3.98 (3H, s, OCH3), 6.76 (1H, d,  J 8.8, 6-H), 7.27 (1H, d, J 8.4, 5-H), 7.47-7.30 (5H, m, Phenyl H), 7.71 (1H, br s, NH)","415(M+, 15.35), 105(100.00)\n","C20H18BrNO4\nC;57.71 (57.69)\nH;4.36 (4.31)\nN;3.36 (3.35)"]
["(E)-19a",60,"oil","δH (500 MHz; CDCl3; Me4Si) 1.12 (3H, t, J 7.4, CH2CH3), 1.18 (3H, t, J 7.4, CH2CH3), 2.23 (3H, s, COCH3), 2.31 (3H, d, J 1.4, CCH3=CH), 2.62 (3H, s, COCH3), 3.35 (2H, q, J 6.9, CH2CH3), 3.45 (2H, q, J 7.4, CH2CH3), 4.03 (3H, s, OCH3), 5.83 (1H, d, J 1.4, CCH3=CH), 6.93 (1H, d,  J 7.8, 6-H), 7.10 (1H, d, J 7.8, 5-H), 8.48 (1H, br s, NH)","386(M+, 43.23), 244(100.00)","C21H26N2O5 386.1842 (386.1838)"]
["(E)-19b",21,"197.3-199.2","δH (400 MHz; CDCl3; Me4Si) 2.31 (3H, d, J 1.1, CCH3=CH), 2.63 (3H, s, COCH3), 2.81 (2H, t, J 6.9, NCH2CH2), 3.58 (2H, m, NCH2CH2), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 4.02 (3H, s, OCH3), 5.51 (1H, d, J 1.1, CCH3=CH), 5.58 (1H, br s, NHCH2CH2), 6.74-6.77 (3H, m, 2'-, 6'-H), 6.82 (1H, d, J 8.8, 5'-H), 6.92 (1H, d,  J 8.0, 6-H), 7.13 (1H, d, J 8.4, 5-H), 8.62 (1H, brs, NH)","494(M+, 4.88), 164(100.00)\n","C27H30N2O7·        ½CH3OH C;64.69(65.00) H;6.32(6.18) N;5.49(5.64)"]
["(E)-19c",33.7,"136.8-138.6","δH (500 MHz; CDCl3; Me4Si) 1.13 (3H, t, J 7.3, CH2CH3), 1.15 (3H, t, J 7.3, CH2CH3), 1.29 (9H, s, C(CH3)3), 2.41 (3H, d, J 1.3, CCH3=CH), 2.64 (3H, s, COCH3), 3.38 (2H, q, J 7.4, CH2CH3), 3.42 (2H, q, J 7.4, CH2CH3), 4.02 (3H, s, OCH3), 5.91 (1H, d, J 1.4, CCH3=CH), 6.92 (1H, d,  J 8.2, 6-H), 7.11 (1H, d, J 8.2, 5-H), 8.92 (1H, br s, NH)","428(M+, 99.69), 272(100.00)\n","C24H32N2O5·½H2O C;65.88 (66.89)\nH;7.60 (7.60)\nN;6.40 (6.46)"]
["(E)-19d",15.1,"105.6-106.9","δH (400 MHz; CDCl3; Me4Si) 1.11 (3H, t, J 7.3, CH2CH3), 1.18 (3H, t, J 7.0, CH2CH3), 1.22 (3H, t, J 7.3, OCH2CH3), 2.31 (3H, d, J 1.5, CCH3=CH), 2.61 (3H, s, COCH3), 2.69-2.73 (2H, m, CH2CH2), 2.78-2.82 (2H, m, CH2CH2), 3.34 (2H, q, J 7.0, NCH2CH3), 3.44 (2H, q, J 7.0, NCH2CH3), 4.02 (3H, s, OCH3), 4.12 (2H, q, J 7.0, OCH2CH3), 5.82 (1H, d, J 1.4, CCH3=CH), 6.91 (1H, d,  J 8.4, 6-H), 7.10 (1H, d, J 8.0, 5-H), 8.69 (1H, br s, NH)","472(M+, 26.43), 244(100.00)","C25H32N2O7 C;63.54 (63.25)\nH;6.83 (6.90)\nN;5.93 (5.90)\n"]
["(E)-19e",19.7,"166.6-168.2","δH (400 MHz; CDCl3; Me4Si) 1.23 (3H, t, J 7.0, OCH2CH3), 2.30 (3H, d, J 1.1, CCH3=CH), 2.62 (3H, s, COCH3), 2.69-2.73 (2H, m, CH2CH2), 2.78-2.82 (2H, m, CH2CH2), 3.47-3.72 (8H, m, NCH2CH2O×2), 4.02 (3H, s, OCH3), 4.13 (2H, q, J 7.0, OCH2CH3), 5.76 (1H, d, J 1.4, CCH3=CH), 6.58 (1H, d,  J 8.4, 6-H), 7.11 (1H, d, J 8.1, 5-H), 8.76 (1H, br s, NH)","486(M+, 27.53), 244(100.00)","C25H30N2O8  C;61.72 (61.66)\nH;6.22 (6.29)\nN;5.76 (5.84)\n"]
["(E)-19f",20.4,"161.3-162.5","δH (400 MHz; CDCl3; Me4Si) 1.23 (3H, t, J 7.0, OCH2CH3), 2.45 (3H, d, J 1.1, CCH3=CH), 2.62 (3H, s, COCH3), 2.59-2.62 (4H, m, CH2CH2COOC2H5), 2.82 (2H, t, NCH2CH2), 3.56-3.61 (2H, m, NCH2CH2), 3.86 (3H, s, OCH3), 3.86 (3H, s, OCH3), 4.01 (3H, s, OCH3), 4.12 (2H, q, J 7.0, OCH2CH3), 5.49 (1H, s, CCH3=CH), 5.93 (1H, br s, NHCH2CH2), 6.75-6.82 (3H, m, 2'-, 5'-, 6'-H), 6.91 (1H, d,  J 8.5, 6-H), 7.12 (1H, d, J 8.4, 5-H), 8.73 (1H, br s, NH)","580(M+, 2.28), 164(100.00)","C31H36N2O9  C;64.13 (63.88)\nH;6.25 (6.33)\nN;4.82 (4.78)\n"]
["(E)-19g",37.5,"180.6-181.3","δH (500 MHz; CDCl3; Me4Si) 1.10 (3H, t, J 7.4, CH2CH3), 1.23 (3H, t, J 7.3, CH2CH3), 1.57 (3H, d, J 7.3, CHCH3), 2.30 (3H, d, J 1.3, CCH3=CH), 2.53 (3H, s, COCH3), 3.35 (2H, q, J 7.4, CH2CH3), 3.50 (2H, q, J 7.3, CH2CH3), 3.91 (1H, q, J 7.4, CHCH3), 4.00 (3H, s, OCH3), 5.84 (1H, d, J 1.4, CCH3=CH), 6.89 (1H, d,  J 8.3, 6-H), 7.08 (1H, d, J 8.2, 5-H), 7.28-7.42 (5H, m, Phenyl H), 8.38 (1H, br s, NH)","476(M+, 63.01), 298(100.00)","C28H32N2O5 C;70.57 (70.39)\nH;6.77 (6.79)\nN;5.88 (5.95)\n"]
["(E)-19h",42,"186.4-189.9","δH (400 MHz; CDCl3; Me4Si) 1.09 (3H, t, J 7.4, CH2CH3), 1.18 (3H, t, J 7.3, CH2CH3), 2.30 (3H, d, J 1.1, CCH3=CH), 2.65 (3H, s, COCH3), 3.29 (2H, q, J 7.3, CH2CH3), 3.43 (2H, q, J 7.3, CH2CH3), 4.04 (3H, s, OCH3), 4.39 (2H, s, CH2), 5.72 (1H, d, J 1.1, CCH3=CH), 6.95 (1H, d,  J 8.4, 6-H), 7.15 (1H, d, J 8.4, 5-H),  9.46 (1H, br s, NH)","420(M+, 40.39), 272(100.00)","C21H25ClN2O5 C;59.93 (59.79)\nH;5.99 (6.06)\nN;6.66 (6.64)\n"]
["(E)-19i",57.9,"206.2-207.9","δH (400 MHz; CDCl3; Me4Si) 1.10 (3H, t, J 7.0, CH2CH3), 1.18 (3H, t, J 7.0, CH2CH3), 2.28 (3H, d, J 1.4, CCH3=CH), 2.63 (3H, s, COCH3), 3.30 (2H, q, J 7.0, CH2CH3), 3.45 (2H, q, J 7.0, CH2CH3), 4.41 (2H, s, CH2), 5.73 (1H, d, J 1.4, CCH3=CH), 5.97 (1H, br s, OH), 6.94 (1H, d,  J 8.0, 6-H), 7.06 (1H, d, J 8.0, 5-H),  9.42 (1H, br s, NH)","406(M+, 33.35), 258(100.00)","C20H23ClN2O5 C;59.04 (58.90)\nH;5.70 (5.70)\nN;6.89 (6.82)\n"]
["(E)-19j",66.7,"131.4-133.3","δH (500 MHz; CDCl3; Me4Si) 1.06 (3H, t, J 7.3, CH2CH3), 1.16 (3H, t, J 7.4, CH2CH3), 1.76 (3H, d, J 6.4, CHCH3), 2.23 (3H, d, J 1.0, CCH3=CH), 2.67 (3H, s, COCH3), 3.26 (2H, q, J 7.3, CH2CH3), 3.42 (2H, q, J 7.3, CH2CH3), 4.38 (2H, s, CH2), 5.51 (1H, q, J 6.5, CHCH3), 5.67 (1H, d, J 1.3, CCH3=CH), 6.81 (1H, d,  J 8.3, 6-H), 6.98 (1H, d, J 8.2, 5-H),  7.27-7.46 (5H, m, Phenyl H), 9.43 (1H, br s, NH)","510(M+, 9.86), 105(100.00)","C28H31ClN2O5 510.1922   (510.1918)"]

{"sheet":"Table S7","index":6,"n_rows":37,"n_cols":7,"rows_kept":37,"cut":false,"hidden":false,"merged":[[0,0,0,5],[36,0,36,6]],"flags":["formulas_cached_only"]}
["Table S7   Physical data and yields of 20, 21, 23 and 24"]
["Compd","Yield      (%)","m.p.     (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+  Calcd (Found)        or Analysis Calcd(Found)","E / Z"]
["20a","23.6","82.5-85.2","δH (60MHz; CDCl3; Me4Si)  2.61 (3H, s, CH3), 2.77 (3H, s, CH3), 7.35-8.11 (3H, m, 4-, 6-, 7-H)","252(M+, 69.50), 237(100.00)","–"]
["20b","43.1","97.4-99.4","δH (60MHz; CDCl3; Me4Si)  2.60 (3H, s, CH3), 2.77 (3H, s, CH3), 7.30-7.93 (3H, m,  4-, 6-, 7-H)","208(M+, 47.15), 193(100.00)","C11H9ClO2    C;63.32 (63.10) H;4.35 (4.25) "]
["20c","64.7","124.0-126.5","δH (60MHz; CDCl3; Me4Si)  2.69 (3H, s, CH3), 2.85 (3H, s, CH3), 7.46-8.94 (3H, m,  4-, 6-, 7-H)","219(M+, 59.76), 204(100.00)","–"]
["20d","75.1","69.3-71.6","δH (60MHz; CDCl3; Me4Si)  2.34 (3H, s, COCH3), 7.38-8.12 (8H, m, 4-, 6-, 7-H, Phenyl H)","270(M+, 60.77), 255(100.00)","–"]
["20e","65.3","104.7-106.3","δH (60MHz; CDCl3; Me4Si) 2.79 (3H, s, CH3), 3.38-3.86 (2H, t, J 5.6, CH2CH2), 7.26-8.07 (3H, m, 4-, 6-, 7-H)","344(M+, 15.75), 237(100.00)","–"]
["20f","66.7","71.5-73.4","δH (60MHz; CDCl3; Me4Si) 1.29 (3H, t, J 6.8, OCH2CH3), 2.79 (3H, s, CH3), 2.79 (2H, t, J 5.6, CH2CH2), 3.23 (2H, t, J 6.0, CH2CH2), 4.20 (2H, q, J 14.0, OCH2CH3), 7.35-8.14 (3H, m, 4-, 6-, 7-H)","338(M+, 40.85), 237(100.00)","–"]
["(E)-21a","5.4","143.1-150.0","δH (400MHz; CDCl3; Me4Si) 2.47 (3H, s, CH3), 2.55 (3H, d, J 1.5, CCH3=CH), 2.84 (2H, t, J 7.0, NHCH2CH2), 3.60 (2H, m, NHCH2CH2), 3.86 (3H, s, OCH3), 3.88 (3H, s, OCH3), 5.52 (1H, br s, NH), 5.76 (1H, q, J 1.1, CCH3=CH), 6.76-6.83 (3H, m, 2'-, 5'-, 6'-H ), 7.26 (1H, d, J 8.7, 7-H), 7.33 (1H, dd, J 8.6 and J 2.0, 6-H), 7.59 (1H, d, J 1.9, 4-H)","457(M+, 9.14), 164(100.00)","C23H24BrNO4 C;60.27 (60.24) H;5.28 (5.39) N;3.06 (3.09)","85 / 15"]
["(Z)-21a","3.7","150.1-150.3","δH (400MHz; CDCl3; Me4Si) 2.12 (3H, d, J 1.5, CCH3=CH), 2.31 (3H, s, CH3), 2.46 (2H, t, J 7.0, NHCH2CH2), 3.37 (2H, m, NHCH2CH2), 3.80 (3H, s, OCH3), 3.85 (3H, s, OCH3), 5.33 (1H, br s, NH), 6.07 (1H, q, J 1.5, CCH3=CH), 6.29 (1H, dd, J 8.3 and 2.0,  6'-H), 6.51 (1H, d, J 1.8, 2'-H), 6.59 (1H, d, J 8.1, 5'-H), 7.27 (1H, d, J 8.5, 7-H), 7.35 (1H, dd, J 8.6 and 2.0, 6-H), 7.46 (1H, d, J 1.8, 4-H)","457(M+, 8.11), 164(100.00)","C23H24BrNO4 C;60.27 (60.06) H;5.28 (5.29) N;3.06 (3.07)"]
["(E)-21ba)","49.5b)","oilb)","δH (400 MHz; CDCl3; Me4Si) 1.21 (6H, t, J 7.0, N(CH2CH3)2), 2.34 (3H, d, J 1.1, CCH3=CH), 2.50 (3H, s, CH3), 3.23-3.52 (4H, m, N(CH2CH3)2), 6.13 (1H, q, J 1.1, CCH3=CH), 7.26 (1H, d, J 8.4, 7-H), 7.32 (1H, dd, J 8.8 and 1.9, 6-H), 7.64 (1H, d, J 2.2, 4-H)","349(M+, 97.16), 198(100.00)","C17H20BrNO2   349.0677 (349.0676)","57 / 43"]
["(Z)-21ba)","–","–","δH (400 MHz; CDCl3; Me4Si) 0.92 (3H, t, J 6.9, NCH2CH3), 1.02 (3H, t, J 6.9, NCH2CH3), 2.16 (3H, d, J 1.5, CCH3=CH), 2.38 (3H, s, CH3), 3.23-3.52 (4H, m, N(CH2CH3)2), 6.22 (1H, q, J 1.5, CCH3=CH), 7.22 (1H, d, J 8.8, 7-H), 7.28 (1H, dd, J 8.8 and 1.8, 6-H), 7.46 (1H, d, J 2.2, 4-H)","–","–"]
["(E)-21c","51.6","73.0-76.0","δH (500MHz; CDCl3; Me4Si) 2.47 (3H, s, CH3), 2.55 (3H, d, J 1.3, CCH3=CH), 2.84 (2H, t, J 7.1, NHCH2CH2), 3.60 (2H, m, NHCH2CH2), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 5.51 (1H, br s, NH), 5.76 (1H, d, J 1.3, CCH3=CH),  6.75-6.77 (2H, m, 6', 2'-H), 6.82 (1H, d, J 8.7, 5'-H), 7.18 (1H, dd, J 8.7 and 1.8, 6-H), 7.30 (1H, d, J 8.7, 7-H), 7.44 (1H, d, J 2.2, 4-H)","413(M+, 8.91), 164(100.00)","C23H24ClNO4 C;66.74 (66.76) H;5.84 (5.90) N;3.38 (3.38)","85 / 15"]
["(Z)-21c","8.3","150.9-151.5","δH (500MHz; CDCl3; Me4Si) 2.11 (3H, d, J 1.4, CCH3=CH), 2.31 (3H, s, CH3), 2.46 (2H, t, J 6.9, NHCH2CH2), 3.37 (2H, m, NHCH2CH2), 3.80 (3H, s, OCH3), 3.85 (3H, s, OCH3), 5.33 (1H, br s, NH), 6.07 (1H, q, J 1.4, CCH3=CH), 6.29 (1H, dd, J 8.2 and 1.9, 6'-H), 6.51 (1H, d, J 1.8, 2'-H), 6.59 (1H, d, J 8.2, 5'-H), 7.21 (1H, dd, J 8.7 and 2.3, 6-H), 7.30 (1H, d, J 2.3, 4-H), 7.46 (1H, d, J 8.7, 7-H)","413(M+, 14.32), 164(100.00)","C23H24ClNO4 C;66.74 (66.45) H;5.84 (5.92) N;3.38 (3.39)"]
["(E)-21d","29.4","139.0-142.0","δH (500MHz; CDCl3; Me4Si) 2.52 (3H, s, CH3), 2.63 (3H, d, J 1.4, CCH3=CH), 3.83 (3H, s, OCH3), 5.97 (1H, d, J 1.3, CCH3=CH),  6.69 (1H, dd, J 8.3 and 2.3, 4'-H), 7.03 (1H, d, J 7.8, 6'-H), 7.20-7.26 (3H, m, 6-H, 5'-H, NH),  7.32 (1H, d, J 8.7, 7-H), 7.38 (1H, s, 2'-H), 7.50 (1H, s, 4-H)","355(M+, 44.10), 233(100.00)","C20H18ClNO3 C;67.51 (67.50) H;5.10 (5.08) N;3.94 (3.97)","50 /50"]
["(E)-21ea)","47.7b)","oilb)","δH (500MHz; CDCl3; Me4Si) 1.21 (6H, t, J 6.9, CH2CH3×2) 2.34 (3H, d, J 1.4, CCH3=CH), 2.50 (3H, s, CH3), 3.42 (2H, q, J 7.3, CH2CH3), 3.49 (2H, q, J 7.4, CH2CH3), 6.13 (1H, q, J 1.4, CCH3=CH), 7.19 (1H, dd, J 8.5 and 1.9, 6-H), 7.31(1H, d, J 8.7, 7-H), 7.48 (1H, d, J 1.8, 4-H)","305(M+, 100.00), 233(92.31)b)","C17H20ClNO2 305.1183 (305.1184)b)","60 / 40"]
["(Z)-21ea)","-","-","δH (500MHz; CDCl3; Me4Si) 0.91 (3H, t, J 6.9, CH2CH3)  1.02 (3H, t, J 6.9, CH2CH3), 2.16 (3H, d, J 1.4, CCH3=CH), 2.37 (3H, s, CH3), 3.24-3.30 (4H, m, CH2CH3×2), 6.22 (1H, q, J 1.4, CCH3=CH), 7.14 (1H, dd, J 8.7 and 2.2, 6-H), 7.27(1H, d, J 8.3, 7-H), 7.31 (1H, d, J 2.3, 4-H)","-","-"]
["(E)-21f a)","42.3b)","oilb)","δH (400MHz; CDCl3; Me4Si) 2.34 (3H, d, J 1.1, CCH3=CH), 2.50 (3H, s, CH3), 3.45-3.73 (8H, m, NCH2CH2O×2),  6.09 (1H, q, J 1.5, CCH3=CH), 7.20 (1H, dd, J 8.6 and 2.1, 6-H), 7.32 (1H, d, J 8.4, 7-H), 7.46 (1H, d, J 1.8, 4-H)","319(M+, 53.25), 233(100.00)b)","C17H18ClNO3 319.0975 (319.0974)b)","72 / 28"]
["(Z)-21f a)","-","-","δH (400MHz; CDCl3; Me4Si) 2.18 (3H, d, J 1.4, CCH3=CH), 2.37 (3H, s, CH3), 3.10-3.57 (8H, m, NCH2CH2O×2), 6.12 (1H, q, J 1.5, CCH3=CH), 7.18 (1H, dd, J 8.3 and 2.2, 6-H), 7.32 (1H, d, J 8.4, 7-H), 7.33 (1H, d, J 1.8, 4-H)","-","-"]
["(E)-21g","5.1","119.4-124.4","δH (400MHz; CDCl3; Me4Si) 2.52 (3H, s, CH3), 2.58 (3H, d, J 1.1, CCH3=CH), 2.85 (2H, t, J 7.0, NHCH2CH2), 3.62 (2H, m, NHCH2CH2), 3.86 (3H, s, OCH3), 3.88 (3H, s, OCH3), 5.57 (1H, br s, NH), 5.82 (1H, d, J 1.5, CCH3=CH), 6.76-6.79 (2H, m, 2'-, 6'-H), 6.83 (1H, d, J 8.0, 5'-H), 7.47 (1H, d, J 8.8, 7-H), 8.18 (1H, dd, J 9.0 and 2.4, 6-H), 8.39 (1H, d, J 2.2, 4-H)","424(M+, 7.87), 164(100.00)","C23H24N2O6\nC;65.08 (64.86) H;5.70 (5.75) N;6.60 (6.42)","69 / 31"]
["(Z)-21g","0.005","145.3-150.2","δH (400MHz; CDCl3; Me4Si) 2.16 (3H, d, J 1.4, CCH3=CH), 2.38 (3H, s, CH3), 2.58 (2H, t, J 6.8, NHCH2CH2), 3.41 (2H, m, NHCH2CH2), 3.81 (3H, s, OCH3), 3.84 (3H, s, OCH3), 5.35 (1H, br, NH), 6.09 (1H, d, J 1.5, CCH3=CH), 6.48 (1H, dd, J 8.2 and 1.8, 6'-H), 6.56 (1H, d, J 1.9, 2'-H), 6.67 (1H, d, J 8.0, 5'-H), 7.47 (1H, d, J 8.8, 7-H), 8.16 (1H, dd, J 8.9 and 2.4, 6-H), 8.23 (1H, d, J 2.5, 4-H)","424(M+, 7.87), 164(100.00)","C23H24N2O6\n424.1634 (424.1631)"]
["(Z)-21h","9.72 ","130.0-134.0","δH (400MHz; CDCl3; Me4Si) 0.91 (3H, m, CH2CH3), 1.13 (3H, m, CH2CH3), 2.21 (3H, d, J 1.1, CCH3=CH), 2.44 (3H, s, CH3), 3.25-3.38 (4H, m, CH2CH3×2),  6.35 (1H, q, J 1.5, CCH3=CH), 7.43 (1H, J 9.1, 7-H), 8.13 (1H, dd, J 9.0 and 2.5, 6-H), 8.24 (1H, d, J 2.2, 4-H)","316(M+, 92.87), 244(100.00)","C17H20N2O4 C;64.54 (64.20) H;6.37 (6.49) N;8.86 (8.77)","44 / 56"]
["(E)-21i",6.94,"161.0-165.0","δH (400MHz; CDCl3; Me4Si) 2.38 (3H, d, J 1.1, CCH3=CH), 2.56 (3H, s, CH3), 3.67-3.75 (8H, m, NCH2CH2O×2), 6.15 (1H, q, J 1.4, CCH3=CH), 7.48 (1H, d, J 9.2, 7-H), 8.16  (1H, d, J 9.0 and 2.4, 6-H), 8.43 (1H, d, J 2.2, 4-H)","330(M+, 68.01), 244(100.00)","C17H18N2O5 330.1216 (330.1215)","63 / 37"]
["(E)-21j         ","51.1","169.1-171.9","δH (500MHz; CDCl3; Me4Si) 2.52 (3H, d, J 1.1, CCH3=CH), 2.84 (2H, t, J 7.1, NHCH2CH2), 3.61 (2H, m, NHCH2CH2), 3.85 (3H, s, OCH3), 3.86 (3H, s, OCH3), 5.51 (1H, br t, J 5.5,  NH), 5.91 (1H, d, J 1.4, CCH3=CH), 6.75-6.82 (3H, m, 2'-, 5'-, 6'-H), 7.26 (1H, dd, J 8.5 and 2.3, 6-H), 7.37-7.47 (4H, m, 7-H, Phenyl H), 7.47 (1H, d, J 2.3, 4-H), 7.76-7.77 (2H, m, Phenyl H)","475(M+, 10.20), 164(100.00)","C28H26ClNO4 475.1550 (475.1545)","85 / 15"]
["(E)-21ka)        ","73.5b)","oilb)","δH (400MHz; CDCl3; Me4Si) 1.16 (3H, t, J 7.2, CH2CH3), 1.22 (3H, t, J 7.2, CH2CH3), 2.31 (3H, d, J 1.5, CCH3=CH), 3.36 (2H, q, J 7.0, CH2CH3), 3.49 (2H, q, J 6.9, CH2CH3), 6.28 (1H, q, J 1.5, CCH3=CH), 7.27 (1H, dd, J 8.6 and 2.2, 6-H), 7.32-7.47 (4H, m, 7-H and Phenyl H), 7.53 (1H, d, J 1.9, 4-H), 7.79-7.82 (2H, m, Phenyl H)","367(M+, 73.03), 295(100.00)b)","C22H22ClNO2 367.1339 (369.1335)b)","85 / 15"]
["(E)-21l","28.1","oil","δH (500MHz; CDCl3; Me4Si) 2.34 (3H, d, J 0.9, CCH3=CH), 3.46-3.72 (8H, m, NCH2CH2O×2),  6.23 (1H, d, J 1.4, CCH3=CH), 7.28 (1H, dd, J 8.7 and 1.9, 6-H), 7.39-7.46 (4H, m, 7-H, Phenyl H), 7.51 (1H, d, J 2.3, 4-H), 7.77-7.79 (2H, m, Phenyl H)","381(M+, 65.82), 295(100.00)","C22H20ClNO3 381.1132 (381.1131)","85 / 15"]
["(Z)-21m","4.2","123.9-126.8","δH (400MHz; CDCl3; Me4Si) 1.20 (3H, t, J 7.3, CH2CH3), 2.30 (3H, s, CH3), 2.35 (2H, t, J 7.4, CH2CH2),  2.45 (2H, t, J 6.6, NHCH2CH2), 2.73 (2H, t, J 7.3, CH2CH2), 3.36 (2H, br, NHCH2CH2), 3.80 (3H, s, OCH3), 3.86 (3H, s, OCH3), 4.06 (2H, q, J 7.3, CH2CH3), 5.32 (1H, br t, J 5.3, NH), 6.10 (1H, s, C=CH), 6.29 (1H, dd, J 8.1 and 1.9, 6'-H), 6.51 (1H, d, J 2.2, 2'-H), 6.61 (1H, d, J 8.1, 5'-H), 7.28 (1H, d, J 8.8, 7-H), 7.35 (1H, dd, J 8.8 and 1.8, 6-H), 7.46 (1H, d, J 1.8, 4-H)","543(M+, 7.40), 164(100.00)","C27H30BrNO6     C;59.56 (59.48) H;5.55 (5.57)  N;2.57 (2.60) ","1 / >99"]
["(Z)-21n","15.4","oil","δH (400MHz; CDCl3; Me4Si) 0.88 (3H, t, J 7.2, CH2CH3), 1.02 (3H, t, J 7.2, CH2CH3), 1.23 (3H, t, J 7.2, CH2CH3), 2.37 (3H, s, CH3), 2.41 (2H, t, J 7.3, CH2CH2),  2.76-2.80 (2H, m, CH2CH2), 3.21-3.30 (4H, m, NHCH2CH3×2), 4.06-4.21 (2H, m, CH2CH3), 6.27 (1H, t, J 1.1, C=CH), 7.23 (1H, d, J 8.0, 7-H), 7.28 (1H,dd, J 8.7 and 2.1, 6-H), 7.47 (1H, d, J 1.9, 4-H)","437(M++2, 100.00) 435(M+, 98.94)","C21H26BrNO4 435.1045 (435.1041)","36 / 64"]
["(E)-21oa)","20.0b)","oilb)","δH (400MHz; CDCl3; Me4Si) 1.14 (3H, t, J 7.2, CH2CH3), 2.41 (2H, t, J 7.3, CH2CH2), 2.46 (3H, s, CH3)  3.04 (2H, t, J 7.8, CH2CH2), 3.15-3.72 (8H, m, NCH2CH2O×2), 3.98 (2H, m, CH2CH3), 6.07 (1H, s, C=CH), 7.27 (1H, d, J 8.7, 7-H), 7.34 (1H,dd, J 8.4 and 2.1, 6-H), 7.57 (1H, d, J 2.3, 4-H) ","451(M++2, 100.00), 449(M+, 99.02)b)","C21H24BrNO5 499.0838 (449.0840)b)","34 / 66"]
["(Z)-21oa)","-","-","δH (400MHz; CDCl3; Me4Si) 1.23 (3H, t, J 7.1, CH2CH3), 2.37 (3H, s, CH3), 2.43 (2H, t, J 7.3, CH2CH2), 2.78-2.81 (2H, m, CH2CH2), 3.15-3.72 (8H, m, NCH2CH2O×2), 4.07-4.16 (2H, m, CH2CH3), 6.18 (1H, s, C=CH), 7.27 (1H, d, J 8.7, 7-H), 7.32 (1H,dd, J 8.3 and 2.4, 6-H), 7.50 (1H, d, J 2.3, 4-H)  ","-","-"]
["22a","33.3","108.1-110.2","δH (400MHz; CDCl3; Me4Si) 1.33 (6H, t, J 7.0, OCH2CH3×2), 2.24-2.36 (2H, m, COCH2CH2), 2.76 (3H, s, CH3), 2.78 (2H, t, J 7.5, NHCH2CH2),  2.90-3.10 (3H, m, COCH2CH2, CH), 3.46-3.61 (2H, m, NHCH2CH2), 3.79 (3H, s, OCH3), 3.85 (3H, s, OCH3), 4.11-4.16 (4H, m, OCH2CH3×2,), 6.68 (1H, br t, J 5.5, NH), 6.71-6.76 (3H, m, 2'-, 5'-, 6'-H), 7.30 (1H, d, J 8.8, 7-H), 7.39 (1H, dd, J 8.6 and 2.1, 6-H), 8.12 (1H, d, J 2.2, 4-H)","623(M+, 2.24), 164(100.00)","C28H35BrNO8P     C;53.85 (53.76) H;5.65 (5.75)  N;2.24 (2.48) \n"]
["22b","63.8","92.7-95.6","δH (400MHz; CDCl3; Me4Si) 1.13 (3H, t, J 7.2, NCH2CH3), 1.19 (3H, t, J 7.2, NCH2CH3), 1.32 (3H, t, J 6.8, OCH2CH3), 1.34 (3H, t, J 7.0, OCH2CH3), 2.32-2.51 (2H, m, COCH2CH2), 2.76 (3H, s, CH3), 2.83-2.93 (1H, m, COCH2CH2), 3.06-3.14 (1H, m, COCH2CH2), 3.22-3.38 (2H, m, NCH2CH3), 3.45-3.55 (2H, m, NCH2CH3, CH), 3.61-3.70 (1H, m, NCH2CH3), 4.11-4.22 (4H, m, OCH2CH3×2), 7.30 (1H, d, J 8.8, 7-H), 7.39 (1H, dd, J 8.6 and 2.0, 6-H), 8.08 (1H, d, J 2.2, 4-H)","515(M+, 30.23), 72(100.00)","C22H31BrNO6P     C;51.17 (50.96) H;6.05 (6.09)  N;2.71 (2.68) "]
[23,80,"oil","δH (60 MHz; CDCl3; Me4Si) 0.94-1.87 (7H, m, CH2CH2CH2CH3), 2.83 (2H, t, J 7.3, CH2(CH2)2CH3), 7.10-7.70 (4H, m, 4-, 5-, 6-, 7-H)","252(M+, 40.11), 209(100.00)","–"]
["(E)-24a",18.5,"oil","δH (400 MHz; CDCl3; Me4Si) 0.94 (3H, t, J 7.3, CH2(CH2)2CH3), 1.16-1.23 (6H, m, N(CH2CH3)2), 1.36-1.45 (2H, m, CH2CH2), 1.68-1.77 (2H, m, CH2CH2), 2.31 (3H, d, J 1.5, CCH3=CH), 2.83 (2H, t, J 7.7, CH2(CH2)CH3), 3.41 (2H, q, J 7.3, NCH2CH3), 3.49 (2H, q, J 7.3, NCH2CH3), 6.14 (1H, q, J 1.1, CCH3=CH), 7.18-1.26 (2H, m, 5-, 6-H), 7.40-7.42 (1H, m, 7-H), 7.50-7.53 (1H, m, 4-H)","313(M+, 100.00)","C20H27NO2 313.2042 (313.2045)"]
["(E)-24b",36.4,"oil","δH (400 MHz; CDCl3; Me4Si) 0.94 (3H, t, J 7.5, CH2(CH2)2CH3), 1.35-1.44 (2H, m, CH2CH3), 1.70-1.77 (2H, m, CH2CH2), 2.36 (3H, d, J 1.1, CCH3=CH), 2.83 (2H, t, J 7.7,  CH2(CH2)2CH3), 3.52-3.78 (8H, m, NCH2CH2O×2), 6.10 (1H, q, J 1.5, CCH3=CH),  7.19-7.26 (2H, m, 5-, 6-H), 7.41 (1H, dd, J 7.5 and 1.6, 7-H), 7.50 (1H, dd, J 7.0 and 1.8, 4-H)","327(M+, 60.45), 213(100.00)","C20H25NO3 327.1834 (327.1834)"]
["(E)-24c",5.6,"95.0-99.0","δH (400 MHz; CDCl3; Me4Si) 0.93 (3H, t, J 7.3, CH2(CH2)2CH3), 1.33-1.43 (2H, m, CH2CH2), 1.68-1.75 (2H, m, CH2CH2), 2.57 (3H, d, J 1.4, CCH3=CH), 2.79 (2H, t, J 7.3, CH2(CH2)2CH3), 2.84 (2H, t, J 6.9, NHCH2CH2), 3.58-3.63 (2H, m, NHCH2CH2), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 5.48 (1H, t, J 5.1, NHCH2CH2), 5.77 (1H, q, J 1.5, CCH3=CH),  6.74-6.82 (3H, m, 2'-, 5'-, 6'-H), 7.17-7.25 (2H, m, 5-, 6-H), 7.40 (1H, dd, J 7.2 and 1.4, 7-H), 7.47 (1H, dd, J 7.4 and 1.4, 4-H)","421(M+, 9.51), 164(100.00)","C26H31NO4\nC;74.08 (74.00)\nH;7.41 (7.54)\nN;3.32 (3.30)"]
["a) Assigned using 1H-NMR of  mixture of  (E)- and (Z)- isomers. b) Mixture of (E)- and (Z)- isomers."]

{"sheet":"Table S8","index":7,"n_rows":7,"n_cols":7,"rows_kept":7,"cut":false,"hidden":false,"merged":[[6,0,6,6],[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S8   Physical data and yields of 25 and 26"]
["Compd","Yield     (%)","m.p.          (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+ Calcd (Found)         or Analysis         Calcd (Found)","E / Z"]
[25,"90.9","33.5-34.0","δH (60MHz; CDCl3; Me4Si)  7.59-8.54 (5H, m, 2-, 4-, 5-, 6-, 7-H ), 10.5 (1H, s, CHO)","146(M+, 77.0), 145(100.00)","–"]
["(E)-26a","41.6","138.1-140.3","δH (500MHz; CDCl3; Me4Si) 2.86 (2H, t, J 6.9, NHCH2CH2), 3.67 (2H, m, NHCH2CH2), 3.87 (6H, s, OCH3×2), 5.63 (1H, br s, NH), 6.45 (1H, d, J 15.6 CH=CH), 6.76-6.79 (2H, m, 2'-, 6'-H), 6.84 (1H, d, J 8.2, 5'-H), 7.29-7.37 (2H, m, 5-, 6-H), 7.52 (1H, d, J 8.2, 7-H), 7.74 (1H, d, J 15.6 , CH=CH), 7.78 (1H, d, J 7.3, 4-H), 7.84 (1H, s, 2-H)","351(M+, 84.22), 164(100.00)","C21H21NO4 351.1471 (351.1472)",">99 / 1"]
["(E)-26b","66.2","oil","δH (400MHz; CDCl3; Me4Si) 1.21-1.34 (6H, m, CH2CH3×2), 3.52 (4H, q, J 7.0, CH2CH3×2),  6.96 (1H, d, J 15.4, CH=CH), 7.32-7.37 (2H, m, 5-, 6-H),  7.33 (1H, m, 7-H), 7.78 (1H, m, 4-H), 7.81 (1H, d, J 15.3, CH=CH), 7.85 (1H, s, 2-H)","243(M+, 63.71), 171(100.00)","C15H17NO2              243.1259 (243.1260)",">99 / 1"]
["(E)-26c","60.2","132.1-134.6","δH (500MHz; CDCl3; Me4Si) 3.73-3.76 (8H, m, NCH2CH2O×2), 6.96 (1H, d, J 15.6, CH=CH), 7.33-7.39 (2H, m, 5-, 6-H), 7.54 (1H, m, 7-H), 7.79 (1H, m, 4-H), 7.82 (1H, d, J 15.6, CH=CH), 7.87 (1H, s, 2-H)","257(M+, 47.88), 171(100.00)","C15H15NO3     C;70.02 (69.87) H;5.88 (5.82)  N;5.44 (5.31) ","88 / 12"]
["a) Assigned using 1H-NMR of  mixture of  (E)- and (Z)- isomers. b) Mixture of (E)- and (Z)- isomers."]

{"sheet":"Table S9","index":8,"n_rows":7,"n_cols":6,"rows_kept":7,"cut":false,"hidden":false,"merged":[[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S9   Physical data and yields of  27"]
["Compd","Yield      (%)","m.p.     (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+  Calcd (Found)        or Analysis Calcd(Found)"]
["(E)-27a",27.3,"oil","δH (400 MHz; CDCl3; Me4Si) 1.19-1.29 (9H, m, OCH2CH3, N(CH2CH3)2), 2.48 (3H, d, J 1.5, CCH3=CH), 2.69 (2H, t,  J 6.6, CH2CH2), 3.24 (2H, t, J 6.6, CH2CH2), 3.51-3.57 (4H, m, N(CH2CH3)2), 4.12 (2H, q, J 7.0, OCH2CH3), 6.85 (1H, d, J 1.1, CCH3=CH), 7.32 (1H, dd, J 8.0, 5-H), 7.43-7.60 (7H, m, 4-, 6-H, Phenyl H)","461(M+, 100.00)","C28H31NO5 461.2202   (461.2204)"]
["(E)-27b",29.5,"145.6-147.4","δH (500 MHz; CDCl3; Me4Si) 1.23 (3H, m, OCH2CH3), 2.69 (2H, t, J 6.8, CH2CH2), 2.75 (3H, d, J 0.9, CCH3=CH), 2.87 (2H, t, J 7.3, NCH2CH2), 3.25 (2H, t, J 6.9, CH2CH2), 3.62-3.66 (2H, m, NCH2CH2), 3.86 (3H, s, OCH3), 3.87 (3H, s, OCH3), 4.12 (2H, q, J 7.3, OCH2CH3), 5.92 (1H, t, J 5.5, NH), 6.51 (1H, d, J 0.9, CCH3=CH), 6.77-6.84 (3H, m, 2'-, 5'-, 6'-H), 7.31 (1H, dd, J 7.8, 5-H), 7.44-7.60 (7H, m, 4-, 6-H, Phenyl H)","569(M+, 5.82), 164(100.00)","C34H35NO7·¼H2O \nC;71.13 (71.27)\nH;6.23 (6.22)\nN;2.44 (2.48)"]
["(E)-27c",38.9,"110.8-113.2","δH (500 MHz; acetone-d6; Me4Si) 2.70 (2H, t, J 6.5, CH2CH2), 2.77 (3H, d, J 1.4, CCH3=CH), 2.82 (2H, t, J 7.3, NCH2CH2), 3.31 (2H, t, J 6.4, CH2CH2), 3.52-3.56 (2H, m, NCH2CH2), 3.77 (3H, s, OCH3), 3.81 (3H, s, OCH3), 6.63 (1H, d, J 1.4, CCH3=CH), 6.79 (1H, dd, J 8.3, 2.3, 6'-H), 6.87 (1H, d, J 8.3, 5'-H), 6.89 (1H, dd, J 2.3, 2'-H), 7.25 (1H, br s, NH), 7.40 (1H, dd, J 7.8, 5-H), 7.46-7.65 (7H, m, 4-, 6-H, phenyl H)","541(M+, 8.18), 164(100.00)","C32H31NO7 \nC;70.97 (70.76)\nH;5.77 (5.76)\nN;2.59 (2.59)"]
["(E)-27d",54.2,"oil","δH (500 MHz; CDCl3; Me4Si) 1.24 (3H, t, J 7.4, OCH2CH3), 2.48 (3H, d, J 0.9, CCH3=CH), 2.68 (2H, t, J 6.9, CH2CH2), 3.19 (2H, t, J 7.4, CH2CH2), 3.73-3.80 (8H, m, NCH2CH2O×2), 4.13 (2H, q, J 6.9, OCH2CH3), 6.87 (1H, d, J 1.0, CCH3=CH), 7.32 (1H, dd, J 7.8, 5-H), 7.41-7.58 (7H, m, 4-, 6-H, Phenyl H)　　　　　","475(M+, 100.00) ","C28H29NO6 475.1995   (475.1992)"]
["(E)-27e",28.6,"175.6-176.4","δH (400 MHz; acetone-d6; Me4Si) 2.46 (3H, d, J 1.1, CCH3=CH), 2.70 (2H, t, J 6.3, CH2CH2), 3.31 (2H, t, J 6.2, CH2CH2), 3.62-3.82 (8H, m, NCH2CH2O×2), 7.03 (1H, d, J 1.2, CCH3=CH), 7.42 (1H, dd, J 7.7, 5-H), 7.47-7.56 (3H, m, Phenyl H), 7.58 (1H, dd, J 7.7 and 1.1, 4-H or 6-H), 7.63-7.67 (2H, m, Phenyl H), 7.70 (1H, dd, J 7.7 and 1.1, 4-H or 6-H)","447(M+, 61.75), 261(100.00)","C26H25NO6 \nC;69.79 (69.50)\nH;5.63 (5.63)\nN;3.13 (3.20)"]

{"sheet":"Table S10","index":9,"n_rows":9,"n_cols":6,"rows_kept":9,"cut":false,"hidden":false,"merged":[[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S10   Physical data and yields of 28, 29, 30 and 31"]
["Compd","Yield      (%)","m.p.     (°C)","1H-NMR","MS m/z (int.)","formula                 HR-MS m/z M+  Calcd (Found)        or Analysis Calcd(Found)"]
[28,44.4,"78.0-79.0","δH (60 MHz; CDCl3; Me4Si) 7.55 (1H, s, 6-H or 4-H), 7.78 (1H, s, 6-H or 4-H), 9.85 (1H, s, CHO), 11.48 (1H, s, OH),","234(M+, 100.00) ","–"]
[29,"56.1     from 28","167.2-167.6","δH (60 MHz; acetone-d6; Me4Si) 7.72 (1H, d, J 2.4, 3-H or 5-H), 7.72 (1H, d, J 2.0, 3-H or 5-H)","233(100.00), 231(M+, 76.95) ","–"]
["30a",41.9,"256.3-256.5","δH (400 MHz; DMSO-d6; Me4Si) 2.40 (3H, s, COCH3), 6.93 (2H, br s, NH2), 7.87 (1H, d, J 1.7, 4-H or 6-H), 8.13 (1H, d, J 2.0, 4-H or 6-H)","289(100.00), 287(M+, 76.55),","C10H7BrClNO2 \nC;41.63 (41.38)\nH;2.45 (2.38)\nN;4.85 (4.90)"]
["30b",14.2,"125.0-125.5","δH (60 MHz; CDCl3; Me4Si) 2.64 (3H, s, COCH3), 7.47-7.62 (3H, m, 3-, 4-. 6-H)","272(M+, 67.76),   259 (100.00)","–"]
["30c",88.9,"161.6-165.9","δH (500 MHz; CDCl3; Me4Si) 1.27 (3H, t, J 7.3, OCH2CH3), 2.64 (3H, s, COCH3), 2.75-2.84 (4H, m, CH2CH2), 4.18 (2H, q, J 7.3, OCH2CH3), 7.66 (1H, d, J 1.8, 4-H or 6-H), 8.52 (1H, d, J 1.8, 4-H or 6-H), 10.13 (1H, br s, NH)","415(M+, 24.49), 129(100.00)","C16H15BrClNO5 \nC;46.12 (46.22)\nH;3.63 (3.60)\nN;3.36 (3.32)"]
["(E)-31a",11.9,"131.4-131.8","δH (500 MHz; CDCl3; Me4Si) 1.27 (3H, t, J 6.9, OCH2CH3), 2.39 (3H, d, J 0.9, CCH3=CH), 2.58 (3H, s, COCH3), 2.76-2.85 (4H, m, CH2CH2), 3.60-3.77 (8H, m, OCH2CH2N×2), 4.18 (2H, q, J 7.4, OCH2CH3), 6.62 (1H, d, J 1.4, CCH3=CH), 7.46 (1H, d, J 2.3, 6-H), 8.49 (1H, d, J 2.3, 4-H), 10.11 (1H, br s, NH)","490(M+, 88.79), 358(100.00)","C24H27ClN2O7 \nC;58.72 (58.50)\nH;5.54 (5.62)\nN;5.71 (5.69)"]
["(E)-31b",19.7,"116.0-117.5","δH (400 MHz; CDCl3; Me4Si) 1.23 (6H, t, J 7.0, CH2CH3×2), 4.41 (3H, d, J 1.5, CCH3=CH), 2.60 (3H, s, COCH3), 3.49-3.55 (4H, m, CH2CH3×2), 6.87 (1H, q, J 1.1, CCH3=CH), 7.46 (1H, d, J 2.2, 6-H), 7.61 (1H, d, J 2.2, 4-H)","333(M+, 41.51), 43(100.00)","C18H20ClNO3\nC;64.77 (64.59)\nH;6.04 (6.09)\nN;4.20 (4.22)"]