# Supplementary Material (ESI) for Organic & Biomolecular Chemistry
# This journal is (c) The Royal Society of Chemistry 2008


##Title:Synthesis of Polyhydroxylated Piperidines and their Analogues: 
##A novel approach for selective inhibitors of alpha-glucosidase
##Communicated to J.Org. Chemistry
##By Ganesh Pandey, Kishor C. Bharadwaj, M. Islam Khan, 
##K. S. Shashidhara and Vedavati G. Puranik
##Division of Organic Chemistry, Division of Biochemical Sciences
##and Centre For Materials Characterisation
##National Chemical Laboratory Pune 411 008, India.
 
data_Compound18a 
 
_audit_creation_method            SHELXL-97 
_chemical_name_systematic 
; 
 ? 
; 
_chemical_name_common             'diols' 
_chemical_melting_point           '152-154 degree centigrade' 
_chemical_formula_moiety          'C16 H23 N O4' 
_chemical_formula_sum 
 'C16 H23 N O4' 
_chemical_formula_weight          293.35 
 
loop_ 
 _atom_type_symbol 
 _atom_type_description 
 _atom_type_scat_dispersion_real 
 _atom_type_scat_dispersion_imag 
 _atom_type_scat_source 
 'C'  'C'   0.0033   0.0016 
 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' 
 'H'  'H'   0.0000   0.0000 
 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' 
 'N'  'N'   0.0061   0.0033 
 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' 
 'O'  'O'   0.0106   0.0060 
 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' 
 
_symmetry_cell_setting            'monoclinic' 
_symmetry_space_group_name_H-M    'P21' 
 
loop_ 
 _symmetry_equiv_pos_as_xyz 
 'x, y, z' 
 '-x, y+1/2, -z' 
 
_cell_length_a                    10.8722(10) 
_cell_length_b                    5.6676(5) 
_cell_length_c                    12.9160(12) 
_cell_angle_alpha                 90.00 
_cell_angle_beta                  106.8390(10) 
_cell_angle_gamma                 90.00 
_cell_volume                      761.75(12) 
_cell_formula_units_Z             2 
_cell_measurement_temperature     273(2) 
_cell_measurement_reflns_used     '1672' 
_cell_measurement_theta_min       '2.908' 
_cell_measurement_theta_max       '27.334' 
 
_exptl_crystal_description        'needle' 
_exptl_crystal_colour             colourless' 
_exptl_crystal_size_max           0.34 
_exptl_crystal_size_mid           0.14 
_exptl_crystal_size_min           0.05 
_exptl_crystal_density_meas       ? 
_exptl_crystal_density_diffrn     1.279 
_exptl_crystal_density_method     'not measured' 
_exptl_crystal_F_000              316 
_exptl_absorpt_coefficient_mu     0.091 
_exptl_absorpt_correction_type    'multi-scan'
_exptl_absorpt_correction_T_min   0.9698 
_exptl_absorpt_correction_T_max   0.9957 
_exptl_absorpt_process_details    'Bruker SADABS' 
 
_exptl_special_details 
; 
 ? 
; 
 
_diffrn_ambient_temperature       273(2) 
_diffrn_radiation_wavelength      0.71073 
_diffrn_radiation_type            MoK\a 
_diffrn_radiation_source          'fine-focus sealed tube' 
_diffrn_radiation_monochromator   graphite 
_diffrn_measurement_device_type   'CCD Area Detector'
_diffrn_measurement_device        'Bruker Smart APEX'  
_diffrn_measurement_method        'Omega Scan'
_diffrn_detector_area_resol_mean  ? 
_diffrn_standards_number          ? 
_diffrn_standards_interval_count  ? 
_diffrn_standards_interval_time   ? 
_diffrn_standards_decay_%         ? 
_diffrn_reflns_number             3761 
_diffrn_reflns_av_R_equivalents   0.0284 
_diffrn_reflns_av_sigmaI/netI     0.0498 
_diffrn_reflns_limit_h_min        -12 
_diffrn_reflns_limit_h_max        12 
_diffrn_reflns_limit_k_min        -6 
_diffrn_reflns_limit_k_max        6 
_diffrn_reflns_limit_l_min        -15 
_diffrn_reflns_limit_l_max        13 
_diffrn_reflns_theta_min          2.16 
_diffrn_reflns_theta_max          25.00 
_reflns_number_total              2445 
_reflns_number_gt                 2252 
_reflns_threshold_expression      >2sigma(I) 
 
_computing_data_collection        'BRUKER SMART' 
_computing_cell_refinement        'BRUKER SAINT'  
_computing_data_reduction         'BRUKER SAINT' 
_computing_structure_solution     'SHELXS-97 (Sheldrick, 1990)' 
_computing_structure_refinement   'SHELXL-97 (Sheldrick, 1997)' 
_computing_molecular_graphics     'SHELXTL and PLATON' 
_computing_publication_material   'SHELXTL' 
 
_refine_special_details 
; 
 Refinement of F^2^ against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F^2^, conventional R-factors R are based 
 on F, with F set to zero for negative F^2^. The threshold expression of 
 F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F^2^ are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
; 
 
_refine_ls_structure_factor_coef  Fsqd  
_refine_ls_matrix_type            full 
_refine_ls_weighting_scheme       calc  
_refine_ls_weighting_details 
 'calc w=1/[\s^2^(Fo^2^)+(0.0568P)^2^+0.0627P] where P=(Fo^2^+2Fc^2^)/3' 
_atom_sites_solution_primary      direct 
_atom_sites_solution_secondary    difmap 
_atom_sites_solution_hydrogens    geom 
_refine_ls_hydrogen_treatment     riding
_refine_ls_extinction_method      none 
_refine_ls_extinction_coef        ? 
_refine_ls_abs_structure_details 
 'Flack H D (1983), Acta Cryst. A39, 876-881' 
_refine_ls_abs_structure_Flack    -1.5(16) 
_refine_ls_number_reflns          2445 
_refine_ls_number_parameters      194 
_refine_ls_number_restraints      1 
_refine_ls_R_factor_all           0.0532 
_refine_ls_R_factor_gt            0.0482 
_refine_ls_wR_factor_ref          0.1252 
_refine_ls_wR_factor_gt           0.1185 
_refine_ls_goodness_of_fit_ref    1.143 
_refine_ls_restrained_S_all       1.143 
_refine_ls_shift/su_max           0.000 
_refine_ls_shift/su_mean          0.000 
 
loop_ 
 _atom_site_label 
 _atom_site_type_symbol 
 _atom_site_fract_x 
 _atom_site_fract_y 
 _atom_site_fract_z 
 _atom_site_U_iso_or_equiv 
 _atom_site_adp_type 
 _atom_site_occupancy 
 _atom_site_symmetry_multiplicity 
 _atom_site_calc_flag 
 _atom_site_refinement_flags 
 _atom_site_disorder_assembly 
 _atom_site_disorder_group 
O1 O -0.18205(17) 0.2696(4) 0.72335(14) 0.0375(5) Uani 1 1 d . . . 
C2 C -0.2458(3) 0.1179(6) 0.6338(2) 0.0393(7) Uani 1 1 d . . . 
O3 O -0.15099(18) 0.0603(4) 0.58011(15) 0.0468(6) Uani 1 1 d . . . 
C3A C -0.0291(3) 0.1077(5) 0.6580(2) 0.0354(6) Uani 1 1 d . . . 
H3A H -0.0088 -0.0190 0.7120 0.042 Uiso 1 1 calc R . . 
C4 C 0.0838(3) 0.1471(6) 0.6151(2) 0.0429(7) Uani 1 1 d . . . 
H4A H 0.1029 0.0054 0.5806 0.051 Uiso 1 1 calc R . . 
H4B H 0.0666 0.2748 0.5629 0.051 Uiso 1 1 calc R . . 
N5 N 0.1908(2) 0.2073(4) 0.70958(17) 0.0380(6) Uani 1 1 d . . . 
C6 C 0.1652(3) 0.4196(6) 0.7666(2) 0.0378(7) Uani 1 1 d . . . 
H6A H 0.1532 0.5534 0.7179 0.045 Uiso 1 1 calc R . . 
H6B H 0.2399 0.4516 0.8275 0.045 Uiso 1 1 calc R . . 
C7 C 0.0476(3) 0.3976(5) 0.8079(2) 0.0319(6) Uani 1 1 d . . . 
C7A C -0.0608(3) 0.3285(5) 0.7089(2) 0.0316(6) Uani 1 1 d . . . 
H7A H -0.0736 0.4566 0.6559 0.038 Uiso 1 1 calc R . . 
C8 C 0.0690(3) 0.2253(5) 0.9013(2) 0.0398(7) Uani 1 1 d . . . 
H8A H 0.0874 0.0706 0.8774 0.048 Uiso 1 1 calc R . . 
H8B H 0.1432 0.2752 0.9592 0.048 Uiso 1 1 calc R . . 
C9 C -0.2916(3) -0.0963(7) 0.6787(3) 0.0601(9) Uani 1 1 d . . . 
H9A H -0.3361 -0.1981 0.6204 0.090 Uiso 1 1 calc R . . 
H9B H -0.3489 -0.0502 0.7194 0.090 Uiso 1 1 calc R . . 
H9C H -0.2194 -0.1786 0.7252 0.090 Uiso 1 1 calc R . . 
C10 C -0.3527(3) 0.2502(8) 0.5551(3) 0.0590(9) Uani 1 1 d . . . 
H10A H -0.3183 0.3868 0.5295 0.088 Uiso 1 1 calc R . . 
H10B H -0.4149 0.2985 0.5906 0.088 Uiso 1 1 calc R . . 
H10C H -0.3931 0.1496 0.4951 0.088 Uiso 1 1 calc R . . 
C11 C 0.3099(3) 0.2360(8) 0.6798(2) 0.0519(8) Uani 1 1 d . . . 
H11A H 0.3050 0.3814 0.6392 0.062 Uiso 1 1 calc R . . 
H11B H 0.3174 0.1069 0.6327 0.062 Uiso 1 1 calc R . . 
C12 C 0.4290(3) 0.2423(6) 0.7753(2) 0.0396(6) Uani 1 1 d . . . 
C13 C 0.4552(3) 0.0605(6) 0.8504(3) 0.0479(8) Uani 1 1 d . . . 
H13 H 0.3969 -0.0628 0.8431 0.058 Uiso 1 1 calc R . . 
C14 C 0.5673(3) 0.0593(7) 0.9364(3) 0.0517(8) Uani 1 1 d . . . 
H14 H 0.5832 -0.0632 0.9864 0.062 Uiso 1 1 calc R . . 
C15 C 0.6544(3) 0.2404(7) 0.9471(3) 0.0523(8) Uani 1 1 d . . . 
H15 H 0.7299 0.2398 1.0040 0.063 Uiso 1 1 calc R . . 
C16 C 0.6297(3) 0.4213(7) 0.8738(3) 0.0526(8) Uani 1 1 d . . . 
H16 H 0.6884 0.5441 0.8813 0.063 Uiso 1 1 calc R . . 
C17 C 0.5178(3) 0.4224(6) 0.7887(2) 0.0445(7) Uani 1 1 d . . . 
H17 H 0.5021 0.5467 0.7396 0.053 Uiso 1 1 calc R . . 
O2 O 0.0229(2) 0.6299(3) 0.84164(14) 0.0422(5) Uani 1 1 d . . . 
H2 H 0.0227 0.6261 0.9051 0.063 Uiso 1 1 calc R . . 
O4 O -0.0384(2) 0.2091(5) 0.94159(15) 0.0530(6) Uani 1 1 d . . . 
H4 H -0.1041 0.1963 0.8909 0.079 Uiso 1 1 calc R . . 
 
loop_ 
 _atom_site_aniso_label 
 _atom_site_aniso_U_11 
 _atom_site_aniso_U_22 
 _atom_site_aniso_U_33 
 _atom_site_aniso_U_23 
 _atom_site_aniso_U_13 
 _atom_site_aniso_U_12 
O1 0.0340(10) 0.0437(12) 0.0371(9) -0.0056(9) 0.0138(8) -0.0033(9) 
C2 0.0347(15) 0.0432(17) 0.0387(14) -0.0121(13) 0.0086(13) -0.0011(14) 
O3 0.0362(11) 0.0614(15) 0.0399(11) -0.0200(10) 0.0064(9) -0.0028(11) 
C3A 0.0339(15) 0.0378(16) 0.0317(13) -0.0083(12) 0.0053(12) -0.0010(13) 
C4 0.0390(16) 0.0553(19) 0.0344(14) -0.0076(13) 0.0107(13) 0.0014(15) 
N5 0.0317(12) 0.0495(16) 0.0326(11) -0.0037(11) 0.0088(9) 0.0015(12) 
C6 0.0401(16) 0.0389(16) 0.0326(13) -0.0001(12) 0.0078(12) -0.0047(15) 
C7 0.0400(15) 0.0268(14) 0.0285(13) -0.0018(11) 0.0093(12) 0.0001(13) 
C7A 0.0365(14) 0.0320(15) 0.0275(12) 0.0043(10) 0.0113(11) 0.0040(12) 
C8 0.0514(17) 0.0361(16) 0.0301(13) 0.0042(12) 0.0090(12) 0.0043(15) 
C9 0.054(2) 0.052(2) 0.076(2) -0.0089(18) 0.0225(19) -0.0109(19) 
C10 0.0480(18) 0.077(3) 0.0454(17) -0.0129(19) 0.0038(14) 0.007(2) 
C11 0.0407(16) 0.077(2) 0.0401(15) -0.0036(17) 0.0154(13) 0.0001(19) 
C12 0.0319(14) 0.0520(18) 0.0387(14) -0.0032(14) 0.0162(11) 0.0016(15) 
C13 0.0421(18) 0.0467(19) 0.0560(18) 0.0003(15) 0.0158(16) -0.0049(15) 
C14 0.0454(18) 0.053(2) 0.0552(19) 0.0092(16) 0.0126(16) 0.0062(17) 
C15 0.0349(16) 0.068(2) 0.0521(17) -0.0060(18) 0.0091(14) 0.0052(18) 
C16 0.0415(18) 0.056(2) 0.062(2) -0.0069(17) 0.0184(17) -0.0126(18) 
C17 0.0393(16) 0.0481(18) 0.0481(17) 0.0040(14) 0.0158(14) 0.0010(16) 
O2 0.0658(13) 0.0266(10) 0.0350(10) -0.0020(8) 0.0160(10) 0.0016(10) 
O4 0.0602(13) 0.0617(15) 0.0388(10) 0.0128(11) 0.0171(10) -0.0032(13) 
 
_geom_special_details 
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
; 
 
loop_ 
 _geom_bond_atom_site_label_1 
 _geom_bond_atom_site_label_2 
 _geom_bond_distance 
 _geom_bond_site_symmetry_2 
 _geom_bond_publ_flag 
O1 C7A 1.424(3) . ? 
O1 C2 1.446(3) . ? 
C2 O3 1.437(3) . ? 
C2 C9 1.492(5) . ? 
C2 C10 1.504(4) . ? 
O3 C3A 1.439(3) . ? 
C3A C7A 1.500(4) . ? 
C3A C4 1.502(4) . ? 
C3A H3A 0.9800 . ? 
C4 N5 1.461(3) . ? 
C4 H4A 0.9700 . ? 
C4 H4B 0.9700 . ? 
N5 C11 1.463(3) . ? 
N5 C6 1.479(4) . ? 
C6 C7 1.526(4) . ? 
C6 H6A 0.9700 . ? 
C6 H6B 0.9700 . ? 
C7 O2 1.437(3) . ? 
C7 C8 1.516(4) . ? 
C7 C7A 1.518(4) . ? 
C7A H7A 0.9800 . ? 
C8 O4 1.412(3) . ? 
C8 H8A 0.9700 . ? 
C8 H8B 0.9700 . ? 
C9 H9A 0.9600 . ? 
C9 H9B 0.9600 . ? 
C9 H9C 0.9600 . ? 
C10 H10A 0.9600 . ? 
C10 H10B 0.9600 . ? 
C10 H10C 0.9600 . ? 
C11 C12 1.508(4) . ? 
C11 H11A 0.9700 . ? 
C11 H11B 0.9700 . ? 
C12 C17 1.381(5) . ? 
C12 C13 1.387(4) . ? 
C13 C14 1.391(5) . ? 
C13 H13 0.9300 . ? 
C14 C15 1.376(5) . ? 
C14 H14 0.9300 . ? 
C15 C16 1.368(5) . ? 
C15 H15 0.9300 . ? 
C16 C17 1.384(5) . ? 
C16 H16 0.9300 . ? 
C17 H17 0.9300 . ? 
O2 H2 0.8200 . ? 
O4 H4 0.8200 . ? 
 
loop_ 
 _geom_angle_atom_site_label_1 
 _geom_angle_atom_site_label_2 
 _geom_angle_atom_site_label_3 
 _geom_angle 
 _geom_angle_site_symmetry_1 
 _geom_angle_site_symmetry_3 
 _geom_angle_publ_flag 
C7A O1 C2 106.39(19) . . ? 
O3 C2 O1 106.1(2) . . ? 
O3 C2 C9 111.7(3) . . ? 
O1 C2 C9 108.1(2) . . ? 
O3 C2 C10 108.0(2) . . ? 
O1 C2 C10 110.0(3) . . ? 
C9 C2 C10 112.8(3) . . ? 
C2 O3 C3A 105.32(18) . . ? 
O3 C3A C7A 100.4(2) . . ? 
O3 C3A C4 117.1(2) . . ? 
C7A C3A C4 110.7(3) . . ? 
O3 C3A H3A 109.4 . . ? 
C7A C3A H3A 109.4 . . ? 
C4 C3A H3A 109.4 . . ? 
N5 C4 C3A 105.35(19) . . ? 
N5 C4 H4A 110.7 . . ? 
C3A C4 H4A 110.7 . . ? 
N5 C4 H4B 110.7 . . ? 
C3A C4 H4B 110.7 . . ? 
H4A C4 H4B 108.8 . . ? 
C4 N5 C11 111.0(2) . . ? 
C4 N5 C6 112.8(2) . . ? 
C11 N5 C6 110.5(3) . . ? 
N5 C6 C7 113.9(2) . . ? 
N5 C6 H6A 108.8 . . ? 
C7 C6 H6A 108.8 . . ? 
N5 C6 H6B 108.8 . . ? 
C7 C6 H6B 108.8 . . ? 
H6A C6 H6B 107.7 . . ? 
O2 C7 C8 110.4(2) . . ? 
O2 C7 C7A 108.9(2) . . ? 
C8 C7 C7A 114.0(2) . . ? 
O2 C7 C6 106.3(2) . . ? 
C8 C7 C6 112.3(2) . . ? 
C7A C7 C6 104.6(2) . . ? 
O1 C7A C3A 101.6(2) . . ? 
O1 C7A C7 118.2(2) . . ? 
C3A C7A C7 111.3(2) . . ? 
O1 C7A H7A 108.4 . . ? 
C3A C7A H7A 108.4 . . ? 
C7 C7A H7A 108.4 . . ? 
O4 C8 C7 112.5(2) . . ? 
O4 C8 H8A 109.1 . . ? 
C7 C8 H8A 109.1 . . ? 
O4 C8 H8B 109.1 . . ? 
C7 C8 H8B 109.1 . . ? 
H8A C8 H8B 107.8 . . ? 
C2 C9 H9A 109.5 . . ? 
C2 C9 H9B 109.5 . . ? 
H9A C9 H9B 109.5 . . ? 
C2 C9 H9C 109.5 . . ? 
H9A C9 H9C 109.5 . . ? 
H9B C9 H9C 109.5 . . ? 
C2 C10 H10A 109.5 . . ? 
C2 C10 H10B 109.5 . . ? 
H10A C10 H10B 109.5 . . ? 
C2 C10 H10C 109.5 . . ? 
H10A C10 H10C 109.5 . . ? 
H10B C10 H10C 109.5 . . ? 
N5 C11 C12 113.8(2) . . ? 
N5 C11 H11A 108.8 . . ? 
C12 C11 H11A 108.8 . . ? 
N5 C11 H11B 108.8 . . ? 
C12 C11 H11B 108.8 . . ? 
H11A C11 H11B 107.7 . . ? 
C17 C12 C13 117.8(3) . . ? 
C17 C12 C11 121.6(3) . . ? 
C13 C12 C11 120.6(3) . . ? 
C12 C13 C14 121.1(3) . . ? 
C12 C13 H13 119.4 . . ? 
C14 C13 H13 119.4 . . ? 
C15 C14 C13 119.7(3) . . ? 
C15 C14 H14 120.2 . . ? 
C13 C14 H14 120.2 . . ? 
C16 C15 C14 119.9(3) . . ? 
C16 C15 H15 120.1 . . ? 
C14 C15 H15 120.1 . . ? 
C15 C16 C17 120.2(3) . . ? 
C15 C16 H16 119.9 . . ? 
C17 C16 H16 119.9 . . ? 
C12 C17 C16 121.2(3) . . ? 
C12 C17 H17 119.4 . . ? 
C16 C17 H17 119.4 . . ? 
C7 O2 H2 109.5 . . ? 
C8 O4 H4 109.5 . . ? 
 
loop_ 
 _geom_torsion_atom_site_label_1 
 _geom_torsion_atom_site_label_2 
 _geom_torsion_atom_site_label_3 
 _geom_torsion_atom_site_label_4 
 _geom_torsion 
 _geom_torsion_site_symmetry_1 
 _geom_torsion_site_symmetry_2 
 _geom_torsion_site_symmetry_3 
 _geom_torsion_site_symmetry_4 
 _geom_torsion_publ_flag 
C7A O1 C2 O3 9.6(3) . . . . ? 
C7A O1 C2 C9 129.5(2) . . . . ? 
C7A O1 C2 C10 -106.9(3) . . . . ? 
O1 C2 O3 C3A 19.4(3) . . . . ? 
C9 C2 O3 C3A -98.1(3) . . . . ? 
C10 C2 O3 C3A 137.2(3) . . . . ? 
C2 O3 C3A C7A -39.0(3) . . . . ? 
C2 O3 C3A C4 -158.9(3) . . . . ? 
O3 C3A C4 N5 176.0(2) . . . . ? 
C7A C3A C4 N5 61.8(3) . . . . ? 
C3A C4 N5 C11 176.4(3) . . . . ? 
C3A C4 N5 C6 -59.1(3) . . . . ? 
C4 N5 C6 C7 59.4(3) . . . . ? 
C11 N5 C6 C7 -175.8(2) . . . . ? 
N5 C6 C7 O2 -169.2(2) . . . . ? 
N5 C6 C7 C8 70.0(3) . . . . ? 
N5 C6 C7 C7A -54.1(3) . . . . ? 
C2 O1 C7A C3A -33.3(3) . . . . ? 
C2 O1 C7A C7 -155.4(2) . . . . ? 
O3 C3A C7A O1 44.3(2) . . . . ? 
C4 C3A C7A O1 168.7(2) . . . . ? 
O3 C3A C7A C7 171.1(2) . . . . ? 
C4 C3A C7A C7 -64.6(3) . . . . ? 
O2 C7 C7A O1 -73.3(3) . . . . ? 
C8 C7 C7A O1 50.4(3) . . . . ? 
C6 C7 C7A O1 173.4(2) . . . . ? 
O2 C7 C7A C3A 169.7(2) . . . . ? 
C8 C7 C7A C3A -66.6(3) . . . . ? 
C6 C7 C7A C3A 56.4(3) . . . . ? 
O2 C7 C8 O4 60.1(3) . . . . ? 
C7A C7 C8 O4 -62.9(3) . . . . ? 
C6 C7 C8 O4 178.4(2) . . . . ? 
C4 N5 C11 C12 -166.6(3) . . . . ? 
C6 N5 C11 C12 67.6(4) . . . . ? 
N5 C11 C12 C17 -127.8(3) . . . . ? 
N5 C11 C12 C13 54.9(4) . . . . ? 
C17 C12 C13 C14 0.0(4) . . . . ? 
C11 C12 C13 C14 177.4(3) . . . . ? 
C12 C13 C14 C15 -0.5(5) . . . . ? 
C13 C14 C15 C16 0.7(5) . . . . ? 
C14 C15 C16 C17 -0.3(5) . . . . ? 
C13 C12 C17 C16 0.4(4) . . . . ? 
C11 C12 C17 C16 -177.0(3) . . . . ? 
C15 C16 C17 C12 -0.2(5) . . . . ? 
 
_diffrn_measured_fraction_theta_max    0.988 
_diffrn_reflns_theta_full              25.00 
_diffrn_measured_fraction_theta_full   0.988 
_refine_diff_density_max    0.212 
_refine_diff_density_min   -0.165 
_refine_diff_density_rms    0.044