# Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry
# This journal is © The Royal Society of Chemistry 2012


data_global

_journal_coden_Cambridge         177

loop_
_publ_author_name
'Hu, Wenhao'
'Zhang, Xia'
'Ji, Jingjing'
'Zhu, Yingguang'
'Jing, Changcheng'
'Li, Min'

_publ_contact_author_name        'Hu, Wenhao'
_publ_contact_author_email       whu@chem.ecnu.edu.cn

_publ_section_title              
;
A highly diastereoselective three-component tandem 
Michael addition/cyclization reaction to 
multisubstituted pyrrolidines
;

data_z
_database_code_depnum_ccdc_archive 'CCDC 849418'
#TrackingRef 'z.cif'

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
;
?
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C25 H23 N O4'
_chemical_formula_weight         401.44

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Monoclinic
_symmetry_space_group_name_H-M   P2(1)/n

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x+1/2, y+1/2, -z+1/2'
'-x, -y, -z'
'x-1/2, -y-1/2, z-1/2'

_cell_length_a                   11.934(2)
_cell_length_b                   14.466(3)
_cell_length_c                   12.536(2)
_cell_angle_alpha                90.00
_cell_angle_beta                 110.006(5)
_cell_angle_gamma                90.00
_cell_volume                     2033.5(7)
_cell_formula_units_Z            4
_cell_measurement_temperature    173(2)
_cell_measurement_reflns_used    ?
_cell_measurement_theta_min      ?
_cell_measurement_theta_max      ?

_exptl_crystal_description       block
_exptl_crystal_colour            colorless
_exptl_crystal_size_max          0.54
_exptl_crystal_size_mid          0.51
_exptl_crystal_size_min          0.40
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.311
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             848
_exptl_absorpt_coefficient_mu    0.089
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_correction_T_min  0.9536
_exptl_absorpt_correction_T_max  0.9653
_exptl_absorpt_process_details   ?

_exptl_special_details           
;
?
;

_diffrn_ambient_temperature      173(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  ?
_diffrn_measurement_method       ?
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            20571
_diffrn_reflns_av_R_equivalents  0.0829
_diffrn_reflns_av_sigmaI/netI    0.0494
_diffrn_reflns_limit_h_min       -14
_diffrn_reflns_limit_h_max       14
_diffrn_reflns_limit_k_min       -15
_diffrn_reflns_limit_k_max       17
_diffrn_reflns_limit_l_min       -14
_diffrn_reflns_limit_l_max       14
_diffrn_reflns_theta_min         2.03
_diffrn_reflns_theta_max         25.01
_reflns_number_total             3568
_reflns_number_gt                2707
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       ?
_computing_cell_refinement       ?
_computing_data_reduction        ?
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
;
Refinement of F^2^ against ALL reflections. The weighted R-factor wR and
goodness of fit S are based on F^2^, conventional R-factors R are based
on F, with F set to zero for negative F^2^. The threshold expression of
F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is
not relevant to the choice of reflections for refinement. R-factors based
on F^2^ are statistically about twice as large as those based on F, and R-
factors based on ALL data will be even larger.
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[\s^2^(Fo^2^)+(0.0789P)^2^+1.5776P] where P=(Fo^2^+2Fc^2^)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_number_reflns         3568
_refine_ls_number_parameters     271
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0851
_refine_ls_R_factor_gt           0.0605
_refine_ls_wR_factor_ref         0.1752
_refine_ls_wR_factor_gt          0.1490
_refine_ls_goodness_of_fit_ref   1.081
_refine_ls_restrained_S_all      1.081
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
O1 O 0.52413(16) -0.09410(12) 0.77108(16) 0.0406(5) Uani 1 1 d . . .
O2 O 0.56838(17) -0.04565(15) 0.62078(16) 0.0485(5) Uani 1 1 d . . .
O3 O 0.29413(18) 0.23583(12) 0.80782(17) 0.0467(5) Uani 1 1 d . . .
O4 O 0.43033(17) 0.10723(13) 0.59861(16) 0.0414(5) Uani 1 1 d . . .
H4B H 0.4299 0.0826 0.5378 0.062 Uiso 1 1 calc R . .
N1 N 0.42379(18) 0.07895(15) 0.77965(18) 0.0341(5) Uani 1 1 d . . .
C1 C 0.5354(2) 0.12402(17) 0.9739(2) 0.0334(6) Uani 1 1 d . . .
H1A H 0.4698 0.1069 0.9962 0.040 Uiso 1 1 calc R . .
C2 C 0.6371(2) 0.16113(17) 1.0538(2) 0.0372(6) Uani 1 1 d . . .
H2A H 0.6394 0.1705 1.1295 0.045 Uiso 1 1 calc R . .
C3 C 0.7354(2) 0.18465(19) 1.0238(2) 0.0428(7) Uani 1 1 d . . .
H3A H 0.8047 0.2104 1.0782 0.051 Uiso 1 1 calc R . .
C4 C 0.7302(2) 0.16988(19) 0.9135(3) 0.0428(7) Uani 1 1 d . . .
H4A H 0.7976 0.1845 0.8928 0.051 Uiso 1 1 calc R . .
C5 C 0.6286(2) 0.13405(18) 0.8320(2) 0.0380(6) Uani 1 1 d . . .
H5A H 0.6269 0.1248 0.7564 0.046 Uiso 1 1 calc R . .
C6 C 0.5285(2) 0.11164(16) 0.8617(2) 0.0313(6) Uani 1 1 d . . .
C7 C 0.0691(3) -0.0691(2) 0.6660(3) 0.0471(7) Uani 1 1 d . . .
H7A H 0.1265 -0.1147 0.6663 0.057 Uiso 1 1 calc R . .
C8 C -0.0439(3) -0.0965(2) 0.6617(3) 0.0574(9) Uani 1 1 d . . .
H8A H -0.0637 -0.1603 0.6572 0.069 Uiso 1 1 calc R . .
C9 C -0.1270(3) -0.0316(2) 0.6640(3) 0.0550(8) Uani 1 1 d . . .
H9A H -0.2034 -0.0505 0.6636 0.066 Uiso 1 1 calc R . .
C10 C -0.0994(3) 0.0604(2) 0.6668(3) 0.0528(8) Uani 1 1 d . . .
H10A H -0.1569 0.1055 0.6679 0.063 Uiso 1 1 calc R . .
C11 C 0.0124(2) 0.0878(2) 0.6681(2) 0.0440(7) Uani 1 1 d . . .
H11A H 0.0301 0.1518 0.6678 0.053 Uiso 1 1 calc R . .
C12 C 0.0992(2) 0.02280(17) 0.6697(2) 0.0328(6) Uani 1 1 d . . .
C13 C 0.1867(3) 0.0742(2) 0.9731(3) 0.0515(8) Uani 1 1 d . . .
H13A H 0.2171 0.0177 0.9555 0.062 Uiso 1 1 calc R . .
C14 C 0.1220(3) 0.0738(3) 1.0456(3) 0.0721(11) Uani 1 1 d . . .
H14A H 0.1090 0.0173 1.0782 0.086 Uiso 1 1 calc R . .
C15 C 0.0769(3) 0.1535(4) 1.0704(3) 0.0828(14) Uani 1 1 d . . .
H15A H 0.0310 0.1523 1.1191 0.099 Uiso 1 1 calc R . .
C16 C 0.0964(4) 0.2346(4) 1.0267(3) 0.0921(17) Uani 1 1 d . . .
H16A H 0.0643 0.2901 1.0448 0.111 Uiso 1 1 calc R . .
C17 C 0.1644(4) 0.2373(3) 0.9541(3) 0.0681(11) Uani 1 1 d . . .
H17A H 0.1799 0.2948 0.9252 0.082 Uiso 1 1 calc R . .
C18 C 0.2083(2) 0.15663(18) 0.9253(2) 0.0365(6) Uani 1 1 d . . .
C19 C 0.4194(2) 0.03810(18) 0.6740(2) 0.0339(6) Uani 1 1 d . . .
C20 C 0.2956(2) -0.00815(19) 0.6315(2) 0.0373(6) Uani 1 1 d . . .
H20A H 0.2638 -0.0115 0.5476 0.045 Uiso 1 1 calc R . .
H20B H 0.2986 -0.0712 0.6632 0.045 Uiso 1 1 calc R . .
C21 C 0.2215(2) 0.05637(17) 0.6763(2) 0.0330(6) Uani 1 1 d . . .
H21A H 0.2114 0.1160 0.6336 0.040 Uiso 1 1 calc R . .
C22 C 0.3095(2) 0.07313(16) 0.7983(2) 0.0305(6) Uani 1 1 d . . .
H22A H 0.3088 0.0198 0.8488 0.037 Uiso 1 1 calc R . .
C23 C 0.2749(2) 0.16217(16) 0.8437(2) 0.0311(6) Uani 1 1 d . . .
C24 C 0.5147(2) -0.03672(18) 0.6865(2) 0.0354(6) Uani 1 1 d . . .
C25 C 0.6003(3) -0.1735(2) 0.7796(3) 0.0485(7) Uani 1 1 d . . .
H25A H 0.6013 -0.2114 0.8447 0.073 Uiso 1 1 calc R . .
H25B H 0.6815 -0.1526 0.7899 0.073 Uiso 1 1 calc R . .
H25C H 0.5699 -0.2103 0.7100 0.073 Uiso 1 1 calc R . .

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
O1 0.0332(11) 0.0391(10) 0.0492(11) 0.0011(8) 0.0139(9) 0.0021(8)
O2 0.0343(11) 0.0691(14) 0.0439(11) -0.0016(10) 0.0157(9) 0.0115(10)
O3 0.0495(13) 0.0281(10) 0.0587(13) 0.0031(9) 0.0135(10) -0.0011(9)
O4 0.0404(11) 0.0437(11) 0.0407(10) 0.0018(8) 0.0147(9) 0.0003(9)
N1 0.0210(11) 0.0424(12) 0.0384(12) -0.0088(9) 0.0095(9) -0.0045(9)
C1 0.0236(13) 0.0313(13) 0.0430(14) -0.0027(11) 0.0084(11) -0.0003(10)
C2 0.0304(15) 0.0339(13) 0.0421(15) -0.0034(11) 0.0059(12) 0.0024(11)
C3 0.0270(15) 0.0386(15) 0.0540(17) -0.0046(12) 0.0024(12) -0.0038(11)
C4 0.0255(15) 0.0409(15) 0.0591(18) 0.0006(13) 0.0107(13) -0.0031(12)
C5 0.0296(15) 0.0377(14) 0.0460(15) -0.0008(11) 0.0120(12) -0.0029(11)
C6 0.0217(13) 0.0267(12) 0.0421(14) -0.0022(10) 0.0065(11) -0.0004(10)
C7 0.0323(16) 0.0379(15) 0.068(2) 0.0055(13) 0.0127(14) 0.0006(12)
C8 0.0412(19) 0.0501(18) 0.076(2) 0.0113(16) 0.0133(16) -0.0135(15)
C9 0.0247(16) 0.078(2) 0.0563(19) 0.0111(16) 0.0065(13) -0.0073(15)
C10 0.0259(16) 0.065(2) 0.062(2) -0.0017(15) 0.0072(14) 0.0081(14)
C11 0.0284(16) 0.0392(15) 0.0565(17) -0.0050(13) 0.0044(13) 0.0005(12)
C12 0.0242(14) 0.0336(13) 0.0355(13) -0.0015(10) 0.0035(10) 0.0004(10)
C13 0.0484(19) 0.0571(19) 0.0559(18) -0.0171(15) 0.0268(15) -0.0214(15)
C14 0.052(2) 0.110(3) 0.064(2) -0.020(2) 0.0310(18) -0.031(2)
C15 0.0333(19) 0.162(5) 0.050(2) 0.012(3) 0.0105(16) 0.031(2)
C16 0.085(3) 0.137(4) 0.049(2) 0.005(2) 0.016(2) 0.090(3)
C17 0.088(3) 0.066(2) 0.0484(18) 0.0095(16) 0.0210(18) 0.049(2)
C18 0.0195(13) 0.0464(15) 0.0369(14) -0.0063(11) 0.0008(10) 0.0066(11)
C19 0.0251(14) 0.0373(14) 0.0383(14) -0.0037(11) 0.0095(11) -0.0019(11)
C20 0.0251(14) 0.0422(15) 0.0403(14) -0.0079(11) 0.0055(11) -0.0008(11)
C21 0.0251(14) 0.0313(13) 0.0384(14) -0.0010(10) 0.0054(11) -0.0003(10)
C22 0.0221(13) 0.0291(12) 0.0396(14) 0.0003(10) 0.0097(11) -0.0014(10)
C23 0.0186(13) 0.0291(13) 0.0388(14) -0.0017(10) 0.0011(10) -0.0009(10)
C24 0.0234(14) 0.0437(15) 0.0359(14) -0.0079(11) 0.0062(11) -0.0040(11)
C25 0.0385(17) 0.0405(16) 0.0600(19) -0.0026(13) 0.0084(14) 0.0052(13)

_geom_special_details            
;
All esds (except the esd in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell esds are taken
into account individually in the estimation of esds in distances, angles
and torsion angles; correlations between esds in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
O1 C24 1.321(3) . ?
O1 C25 1.446(3) . ?
O2 C24 1.211(3) . ?
O3 C23 1.209(3) . ?
O4 C19 1.413(3) . ?
O4 H4B 0.8400 . ?
N1 C6 1.401(3) . ?
N1 C19 1.435(3) . ?
N1 C22 1.463(3) . ?
C1 C2 1.390(4) . ?
C1 C6 1.392(4) . ?
C1 H1A 0.9500 . ?
C2 C3 1.391(4) . ?
C2 H2A 0.9500 . ?
C3 C4 1.378(4) . ?
C3 H3A 0.9500 . ?
C4 C5 1.391(4) . ?
C4 H4A 0.9500 . ?
C5 C6 1.406(4) . ?
C5 H5A 0.9500 . ?
C7 C12 1.374(4) . ?
C7 C8 1.389(4) . ?
C7 H7A 0.9500 . ?
C8 C9 1.373(5) . ?
C8 H8A 0.9500 . ?
C9 C10 1.368(5) . ?
C9 H9A 0.9500 . ?
C10 C11 1.387(4) . ?
C10 H10A 0.9500 . ?
C11 C12 1.394(4) . ?
C11 H11A 0.9500 . ?
C12 C21 1.514(4) . ?
C13 C14 1.380(4) . ?
C13 C18 1.397(4) . ?
C13 H13A 0.9500 . ?
C14 C15 1.353(6) . ?
C14 H14A 0.9500 . ?
C15 C16 1.348(7) . ?
C15 H15A 0.9500 . ?
C16 C17 1.412(6) . ?
C16 H16A 0.9500 . ?
C17 C18 1.378(4) . ?
C17 H17A 0.9500 . ?
C18 C23 1.497(4) . ?
C19 C24 1.538(4) . ?
C19 C20 1.541(4) . ?
C20 C21 1.519(3) . ?
C20 H20A 0.9900 . ?
C20 H20B 0.9900 . ?
C21 C22 1.550(3) . ?
C21 H21A 1.0000 . ?
C22 C23 1.521(3) . ?
C22 H22A 1.0000 . ?
C25 H25A 0.9800 . ?
C25 H25B 0.9800 . ?
C25 H25C 0.9800 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C24 O1 C25 115.9(2) . . ?
C19 O4 H4B 109.5 . . ?
C6 N1 C19 123.9(2) . . ?
C6 N1 C22 123.2(2) . . ?
C19 N1 C22 112.49(19) . . ?
C2 C1 C6 120.9(2) . . ?
C2 C1 H1A 119.6 . . ?
C6 C1 H1A 119.6 . . ?
C1 C2 C3 120.6(3) . . ?
C1 C2 H2A 119.7 . . ?
C3 C2 H2A 119.7 . . ?
C4 C3 C2 118.7(3) . . ?
C4 C3 H3A 120.7 . . ?
C2 C3 H3A 120.7 . . ?
C3 C4 C5 121.6(3) . . ?
C3 C4 H4A 119.2 . . ?
C5 C4 H4A 119.2 . . ?
C4 C5 C6 119.8(3) . . ?
C4 C5 H5A 120.1 . . ?
C6 C5 H5A 120.1 . . ?
C1 C6 N1 121.0(2) . . ?
C1 C6 C5 118.4(2) . . ?
N1 C6 C5 120.6(2) . . ?
C12 C7 C8 121.1(3) . . ?
C12 C7 H7A 119.5 . . ?
C8 C7 H7A 119.5 . . ?
C9 C8 C7 120.2(3) . . ?
C9 C8 H8A 119.9 . . ?
C7 C8 H8A 119.9 . . ?
C10 C9 C8 119.7(3) . . ?
C10 C9 H9A 120.1 . . ?
C8 C9 H9A 120.1 . . ?
C9 C10 C11 120.1(3) . . ?
C9 C10 H10A 120.0 . . ?
C11 C10 H10A 120.0 . . ?
C10 C11 C12 120.9(3) . . ?
C10 C11 H11A 119.5 . . ?
C12 C11 H11A 119.5 . . ?
C7 C12 C11 117.9(2) . . ?
C7 C12 C21 123.2(2) . . ?
C11 C12 C21 118.8(2) . . ?
C14 C13 C18 120.9(3) . . ?
C14 C13 H13A 119.5 . . ?
C18 C13 H13A 119.5 . . ?
C15 C14 C13 120.2(4) . . ?
C15 C14 H14A 119.9 . . ?
C13 C14 H14A 119.9 . . ?
C16 C15 C14 120.7(3) . . ?
C16 C15 H15A 119.6 . . ?
C14 C15 H15A 119.6 . . ?
C15 C16 C17 120.2(3) . . ?
C15 C16 H16A 119.9 . . ?
C17 C16 H16A 119.9 . . ?
C18 C17 C16 119.9(4) . . ?
C18 C17 H17A 120.0 . . ?
C16 C17 H17A 120.0 . . ?
C17 C18 C13 117.9(3) . . ?
C17 C18 C23 118.2(3) . . ?
C13 C18 C23 123.9(2) . . ?
O4 C19 N1 110.1(2) . . ?
O4 C19 C24 109.4(2) . . ?
N1 C19 C24 113.8(2) . . ?
O4 C19 C20 111.9(2) . . ?
N1 C19 C20 103.05(19) . . ?
C24 C19 C20 108.5(2) . . ?
C21 C20 C19 102.5(2) . . ?
C21 C20 H20A 111.3 . . ?
C19 C20 H20A 111.3 . . ?
C21 C20 H20B 111.3 . . ?
C19 C20 H20B 111.3 . . ?
H20A C20 H20B 109.2 . . ?
C12 C21 C20 117.1(2) . . ?
C12 C21 C22 114.7(2) . . ?
C20 C21 C22 100.22(19) . . ?
C12 C21 H21A 108.1 . . ?
C20 C21 H21A 108.1 . . ?
C22 C21 H21A 108.1 . . ?
N1 C22 C23 113.45(19) . . ?
N1 C22 C21 101.80(19) . . ?
C23 C22 C21 108.86(19) . . ?
N1 C22 H22A 110.8 . . ?
C23 C22 H22A 110.8 . . ?
C21 C22 H22A 110.8 . . ?
O3 C23 C18 121.0(2) . . ?
O3 C23 C22 119.8(2) . . ?
C18 C23 C22 119.0(2) . . ?
O2 C24 O1 124.0(2) . . ?
O2 C24 C19 123.4(2) . . ?
O1 C24 C19 112.4(2) . . ?
O1 C25 H25A 109.5 . . ?
O1 C25 H25B 109.5 . . ?
H25A C25 H25B 109.5 . . ?
O1 C25 H25C 109.5 . . ?
H25A C25 H25C 109.5 . . ?
H25B C25 H25C 109.5 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C6 C1 C2 C3 -1.6(4) . . . . ?
C1 C2 C3 C4 -0.4(4) . . . . ?
C2 C3 C4 C5 1.3(4) . . . . ?
C3 C4 C5 C6 -0.3(4) . . . . ?
C2 C1 C6 N1 -176.5(2) . . . . ?
C2 C1 C6 C5 2.6(4) . . . . ?
C19 N1 C6 C1 -160.2(2) . . . . ?
C22 N1 C6 C1 12.5(4) . . . . ?
C19 N1 C6 C5 20.8(4) . . . . ?
C22 N1 C6 C5 -166.5(2) . . . . ?
C4 C5 C6 C1 -1.6(4) . . . . ?
C4 C5 C6 N1 177.5(2) . . . . ?
C12 C7 C8 C9 -1.6(5) . . . . ?
C7 C8 C9 C10 2.1(5) . . . . ?
C8 C9 C10 C11 -0.4(5) . . . . ?
C9 C10 C11 C12 -1.8(5) . . . . ?
C8 C7 C12 C11 -0.5(4) . . . . ?
C8 C7 C12 C21 179.0(3) . . . . ?
C10 C11 C12 C7 2.2(4) . . . . ?
C10 C11 C12 C21 -177.4(3) . . . . ?
C18 C13 C14 C15 0.8(5) . . . . ?
C13 C14 C15 C16 -1.3(6) . . . . ?
C14 C15 C16 C17 0.0(6) . . . . ?
C15 C16 C17 C18 1.8(6) . . . . ?
C16 C17 C18 C13 -2.3(5) . . . . ?
C16 C17 C18 C23 177.1(3) . . . . ?
C14 C13 C18 C17 1.0(5) . . . . ?
C14 C13 C18 C23 -178.4(3) . . . . ?
C6 N1 C19 O4 -74.9(3) . . . . ?
C22 N1 C19 O4 111.7(2) . . . . ?
C6 N1 C19 C24 48.3(3) . . . . ?
C22 N1 C19 C24 -125.1(2) . . . . ?
C6 N1 C19 C20 165.6(2) . . . . ?
C22 N1 C19 C20 -7.8(3) . . . . ?
O4 C19 C20 C21 -85.6(2) . . . . ?
N1 C19 C20 C21 32.7(3) . . . . ?
C24 C19 C20 C21 153.6(2) . . . . ?
C7 C12 C21 C20 24.3(4) . . . . ?
C11 C12 C21 C20 -156.1(2) . . . . ?
C7 C12 C21 C22 -92.7(3) . . . . ?
C11 C12 C21 C22 86.8(3) . . . . ?
C19 C20 C21 C12 -168.6(2) . . . . ?
C19 C20 C21 C22 -43.9(2) . . . . ?
C6 N1 C22 C23 50.2(3) . . . . ?
C19 N1 C22 C23 -136.3(2) . . . . ?
C6 N1 C22 C21 167.0(2) . . . . ?
C19 N1 C22 C21 -19.5(3) . . . . ?
C12 C21 C22 N1 165.0(2) . . . . ?
C20 C21 C22 N1 38.6(2) . . . . ?
C12 C21 C22 C23 -75.0(3) . . . . ?
C20 C21 C22 C23 158.7(2) . . . . ?
C17 C18 C23 O3 3.0(4) . . . . ?
C13 C18 C23 O3 -177.6(3) . . . . ?
C17 C18 C23 C22 -171.8(3) . . . . ?
C13 C18 C23 C22 7.5(4) . . . . ?
N1 C22 C23 O3 39.6(3) . . . . ?
C21 C22 C23 O3 -73.0(3) . . . . ?
N1 C22 C23 C18 -145.6(2) . . . . ?
C21 C22 C23 C18 101.9(3) . . . . ?
C25 O1 C24 O2 -2.7(4) . . . . ?
C25 O1 C24 C19 172.3(2) . . . . ?
O4 C19 C24 O2 -16.8(3) . . . . ?
N1 C19 C24 O2 -140.4(3) . . . . ?
C20 C19 C24 O2 105.5(3) . . . . ?
O4 C19 C24 O1 168.2(2) . . . . ?
N1 C19 C24 O1 44.6(3) . . . . ?
C20 C19 C24 O1 -69.5(3) . . . . ?

_diffrn_measured_fraction_theta_max 0.997
_diffrn_reflns_theta_full        25.01
_diffrn_measured_fraction_theta_full 0.997
_refine_diff_density_max         0.409
_refine_diff_density_min         -0.322
_refine_diff_density_rms         0.061