# Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.
# This journal is © The Royal Society of Chemistry 2014


data_cd21256

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C20 H32 O'
_chemical_formula_weight         288.46

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Triclinic
_symmetry_space_group_name_H-M   P-1

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, -y, -z'

_cell_length_a                   9.401(4)
_cell_length_b                   9.421(4)
_cell_length_c                   10.588(5)
_cell_angle_alpha                108.301(10)
_cell_angle_beta                 93.150(9)
_cell_angle_gamma                94.391(10)
_cell_volume                     884.7(7)
_cell_formula_units_Z            2
_cell_measurement_temperature    293(2)
_cell_measurement_reflns_used    1349
_cell_measurement_theta_min      4.576
_cell_measurement_theta_max      56.182

_exptl_crystal_description       prismatic
_exptl_crystal_colour            colorless
_exptl_crystal_size_max          0.213
_exptl_crystal_size_mid          0.113
_exptl_crystal_size_min          0.087
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.083
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             320
_exptl_absorpt_coefficient_mu    0.064
_exptl_absorpt_correction_type   empirical
_exptl_absorpt_correction_T_min  0.35962
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_process_details   sadabs

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      293(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  'CCD area detector'
_diffrn_measurement_method       'phi and omega scans'
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            5087
_diffrn_reflns_av_R_equivalents  0.0328
_diffrn_reflns_av_sigmaI/netI    0.0623
_diffrn_reflns_limit_h_min       -11
_diffrn_reflns_limit_h_max       11
_diffrn_reflns_limit_k_min       -11
_diffrn_reflns_limit_k_max       10
_diffrn_reflns_limit_l_min       -7
_diffrn_reflns_limit_l_max       12
_diffrn_reflns_theta_min         2.03
_diffrn_reflns_theta_max         25.50
_reflns_number_total             3290
_reflns_number_gt                2269
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'Bruker SMART'
_computing_cell_refinement       'Bruker SMART'
_computing_data_reduction        'Bruker SHELXTL'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.1142P)²+0.0251P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_number_reflns         3290
_refine_ls_number_parameters     202
_refine_ls_number_restraints     8
_refine_ls_R_factor_all          0.1161
_refine_ls_R_factor_gt           0.0859
_refine_ls_wR_factor_ref         0.2205
_refine_ls_wR_factor_gt          0.2026
_refine_ls_goodness_of_fit_ref   1.091
_refine_ls_restrained_S_all      1.092
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
O1 O 0.9653(2) 0.5066(2) 0.2341(2) 0.0530(6) Uani 1 1 d . . .
C1 C 0.8642(3) 0.5724(3) 0.2237(3) 0.0374(6) Uani 1 1 d . . .
C2 C 0.7477(3) 0.5137(3) 0.1110(2) 0.0366(6) Uani 1 1 d . . .
H2 H 0.6621 0.5588 0.1473 0.044 Uiso 1 1 calc R . .
C3 C 0.7936(3) 0.5961(3) 0.0134(3) 0.0484(8) Uani 1 1 d . . .
H3A H 0.8798 0.5586 -0.0256 0.058 Uiso 1 1 calc R . .
H3B H 0.7187 0.5787 -0.0581 0.058 Uiso 1 1 calc R . .
C4 C 0.8213(3) 0.7627(3) 0.0887(3) 0.0494(8) Uani 1 1 d . . .
C5 C 0.7758(3) 0.8126(3) 0.2288(3) 0.0475(8) Uani 1 1 d . . .
H5A H 0.6723 0.7971 0.2260 0.057 Uiso 1 1 calc R . .
H5B H 0.8044 0.9191 0.2701 0.057 Uiso 1 1 calc R . .
C6 C 0.8436(3) 0.7246(3) 0.3138(3) 0.0398(7) Uani 1 1 d . . .
H6 H 0.9375 0.7765 0.3539 0.048 Uiso 1 1 calc R . .
C7 C 0.7530(3) 0.7053(3) 0.4262(2) 0.0401(7) Uani 1 1 d . . .
H7 H 0.7116 0.8005 0.4638 0.048 Uiso 1 1 calc R . .
C8 C 0.6262(3) 0.5831(3) 0.3767(3) 0.0420(7) Uani 1 1 d . . .
H8A H 0.5720 0.6033 0.3046 0.050 Uiso 1 1 calc R . .
H8B H 0.5643 0.5948 0.4489 0.050 Uiso 1 1 calc R . .
C9 C 0.6572(3) 0.4166(3) 0.3265(3) 0.0458(7) Uani 1 1 d . . .
H9A H 0.7595 0.4145 0.3424 0.055 Uiso 1 1 calc R . .
H9B H 0.6110 0.3669 0.3831 0.055 Uiso 1 1 calc R . .
C10 C 0.6137(3) 0.3192(3) 0.1805(3) 0.0475(7) Uani 1 1 d . . .
H10 H 0.5167 0.3399 0.1578 0.057 Uiso 1 1 calc R . .
C11 C 0.7094(3) 0.3459(3) 0.0739(3) 0.0413(7) Uani 1 1 d . . .
H11 H 0.7979 0.2988 0.0795 0.050 Uiso 1 1 calc R . .
C12 C 0.8864(5) 0.8564(4) 0.0377(4) 0.0823(13) Uani 1 1 d . . .
H12A H 0.9060 0.9572 0.0881 0.099 Uiso 1 1 calc R . .
H12B H 0.9133 0.8224 -0.0492 0.099 Uiso 1 1 calc R . .
C13 C 0.8483(3) 0.6838(3) 0.5411(3) 0.0480(8) Uani 1 1 d . . .
H13 H 0.9035 0.5986 0.5027 0.058 Uiso 1 1 calc R . .
C14 C 0.9539(4) 0.8206(5) 0.6095(3) 0.0796(12) Uani 1 1 d . . .
H14A H 0.9026 0.9068 0.6446 0.119 Uiso 1 1 calc R . .
H14B H 1.0164 0.8381 0.5461 0.119 Uiso 1 1 calc R . .
H14C H 1.0095 0.8032 0.6811 0.119 Uiso 1 1 calc R . .
C15 C 0.7610(4) 0.6481(5) 0.6462(3) 0.0724(11) Uani 1 1 d . . .
H15A H 0.7005 0.7266 0.6806 0.109 Uiso 1 1 calc R . .
H15B H 0.8245 0.6409 0.7176 0.109 Uiso 1 1 calc R . .
H15C H 0.7030 0.5544 0.6066 0.109 Uiso 1 1 calc R . .
C16 C 0.6059(5) 0.1555(4) 0.1748(4) 0.0796(12) Uani 1 1 d . . .
H16A H 0.6977 0.1337 0.2041 0.119 Uiso 1 1 calc R . .
H16B H 0.5794 0.0921 0.0847 0.119 Uiso 1 1 calc R . .
H16C H 0.5357 0.1373 0.2318 0.119 Uiso 1 1 calc R . .
C17 C 0.6361(3) 0.2739(3) -0.0671(3) 0.0513(8) Uani 1 1 d . . .
H17A H 0.5711 0.1885 -0.0680 0.062 Uiso 1 1 calc R . .
H17B H 0.5795 0.3461 -0.0891 0.062 Uiso 1 1 calc R . .
C18 C 0.7390(4) 0.2218(4) -0.1734(3) 0.0703(10) Uani 1 1 d . B .
H18A H 0.8016 0.3079 -0.1750 0.084 Uiso 1 1 calc R . .
H18B H 0.7981 0.1526 -0.1497 0.084 Uiso 1 1 calc R . .
C19 C 0.6672(5) 0.1473(4) -0.3084(3) 0.0718(11) Uani 1 1 d D . .
H19 H 0.6005 0.0677 -0.3119 0.086 Uiso 0.60 1 calc PR A 1
H19' H 0.5979 0.0615 -0.3275 0.086 Uiso 0.40 1 d PR A 2
C20 C 0.676(4) 0.168(3) -0.4208(14) 0.085(4) Uani 0.60 1 d PDU B 1
H20A H 0.7344 0.2490 -0.4274 0.102 Uiso 0.60 1 calc PR B 1
H20B H 0.6251 0.1009 -0.4966 0.102 Uiso 0.60 1 calc PR B 1
C20' C 0.705(6) 0.206(5) -0.397(2) 0.085(4) Uani 0.40 1 d PDU B 2
H20C H 0.6695 0.1622 -0.4858 0.102 Uiso 0.40 1 calc PR B 2
H20D H 0.7685 0.2931 -0.3728 0.102 Uiso 0.40 1 calc PR B 2


_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
O1 C1 1.193(3) . ?
C1 C6 1.485(4) . ?
C1 C2 1.510(4) . ?
C2 C11 1.513(4) . ?
C2 C3 1.536(4) . ?
C2 H2 0.9800 . ?
C3 C4 1.515(4) . ?
C3 H3A 0.9700 . ?
C3 H3B 0.9700 . ?
C4 C12 1.304(4) . ?
C4 C5 1.506(4) . ?
C5 C6 1.546(4) . ?
C5 H5A 0.9700 . ?
C5 H5B 0.9700 . ?
C6 C7 1.549(4) . ?
C6 H6 0.9800 . ?
C7 C8 1.538(4) . ?
C7 C13 1.545(4) . ?
C7 H7 0.9800 . ?
C8 C9 1.546(4) . ?
C8 H8A 0.9700 . ?
C8 H8B 0.9700 . ?
C9 C10 1.543(4) . ?
C9 H9A 0.9700 . ?
C9 H9B 0.9700 . ?
C10 C16 1.520(4) . ?
C10 C11 1.550(4) . ?
C10 H10 0.9800 . ?
C11 C17 1.531(4) . ?
C11 H11 0.9800 . ?
C12 H12A 0.9300 . ?
C12 H12B 0.9300 . ?
C13 C14 1.520(5) . ?
C13 C15 1.523(4) . ?
C13 H13 0.9800 . ?
C14 H14A 0.9600 . ?
C14 H14B 0.9600 . ?
C14 H14C 0.9600 . ?
C15 H15A 0.9600 . ?
C15 H15B 0.9600 . ?
C15 H15C 0.9600 . ?
C16 H16A 0.9600 . ?
C16 H16B 0.9600 . ?
C16 H16C 0.9600 . ?
C17 C18 1.512(4) . ?
C17 H17A 0.9700 . ?
C17 H17B 0.9700 . ?
C18 C19 1.478(5) . ?
C18 H18A 0.9700 . ?
C18 H18B 0.9700 . ?
C19 C20 1.269(12) . ?
C19 C20' 1.287(18) . ?
C19 H19 0.9300 . ?
C19 H19' 0.9600 . ?
C20 H20A 0.9300 . ?
C20 H20B 0.9300 . ?
C20' H20C 0.9300 . ?
C20' H20D 0.9300 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
O1 C1 C6 124.1(2) . . ?
O1 C1 C2 123.2(3) . . ?
C6 C1 C2 112.6(2) . . ?
C1 C2 C11 112.7(2) . . ?
C1 C2 C3 102.2(2) . . ?
C11 C2 C3 125.0(2) . . ?
C1 C2 H2 105.1 . . ?
C11 C2 H2 105.1 . . ?
C3 C2 H2 105.1 . . ?
C4 C3 C2 108.8(2) . . ?
C4 C3 H3A 109.9 . . ?
C2 C3 H3A 109.9 . . ?
C4 C3 H3B 109.9 . . ?
C2 C3 H3B 109.9 . . ?
H3A C3 H3B 108.3 . . ?
C12 C4 C5 121.9(3) . . ?
C12 C4 C3 122.1(3) . . ?
C5 C4 C3 116.0(2) . . ?
C4 C5 C6 111.3(2) . . ?
C4 C5 H5A 109.4 . . ?
C6 C5 H5A 109.4 . . ?
C4 C5 H5B 109.4 . . ?
C6 C5 H5B 109.4 . . ?
H5A C5 H5B 108.0 . . ?
C1 C6 C5 108.2(2) . . ?
C1 C6 C7 107.9(2) . . ?
C5 C6 C7 114.5(2) . . ?
C1 C6 H6 108.7 . . ?
C5 C6 H6 108.7 . . ?
C7 C6 H6 108.7 . . ?
C8 C7 C13 112.3(2) . . ?
C8 C7 C6 113.8(2) . . ?
C13 C7 C6 111.1(2) . . ?
C8 C7 H7 106.3 . . ?
C13 C7 H7 106.3 . . ?
C6 C7 H7 106.3 . . ?
C7 C8 C9 118.7(2) . . ?
C7 C8 H8A 107.6 . . ?
C9 C8 H8A 107.6 . . ?
C7 C8 H8B 107.6 . . ?
C9 C8 H8B 107.6 . . ?
H8A C8 H8B 107.1 . . ?
C10 C9 C8 120.5(2) . . ?
C10 C9 H9A 107.2 . . ?
C8 C9 H9A 107.2 . . ?
C10 C9 H9B 107.2 . . ?
C8 C9 H9B 107.2 . . ?
H9A C9 H9B 106.8 . . ?
C16 C10 C9 107.7(2) . . ?
C16 C10 C11 110.4(3) . . ?
C9 C10 C11 116.5(2) . . ?
C16 C10 H10 107.3 . . ?
C9 C10 H10 107.3 . . ?
C11 C10 H10 107.3 . . ?
C2 C11 C17 113.8(2) . . ?
C2 C11 C10 107.2(2) . . ?
C17 C11 C10 111.3(2) . . ?
C2 C11 H11 108.1 . . ?
C17 C11 H11 108.1 . . ?
C10 C11 H11 108.1 . . ?
C4 C12 H12A 120.0 . . ?
C4 C12 H12B 120.0 . . ?
H12A C12 H12B 120.0 . . ?
C14 C13 C15 108.6(3) . . ?
C14 C13 C7 112.3(3) . . ?
C15 C13 C7 112.4(3) . . ?
C14 C13 H13 107.8 . . ?
C15 C13 H13 107.8 . . ?
C7 C13 H13 107.8 . . ?
C13 C14 H14A 109.5 . . ?
C13 C14 H14B 109.5 . . ?
H14A C14 H14B 109.5 . . ?
C13 C14 H14C 109.5 . . ?
H14A C14 H14C 109.5 . . ?
H14B C14 H14C 109.5 . . ?
C13 C15 H15A 109.5 . . ?
C13 C15 H15B 109.5 . . ?
H15A C15 H15B 109.5 . . ?
C13 C15 H15C 109.5 . . ?
H15A C15 H15C 109.5 . . ?
H15B C15 H15C 109.5 . . ?
C10 C16 H16A 109.5 . . ?
C10 C16 H16B 109.5 . . ?
H16A C16 H16B 109.5 . . ?
C10 C16 H16C 109.5 . . ?
H16A C16 H16C 109.5 . . ?
H16B C16 H16C 109.5 . . ?
C18 C17 C11 113.9(3) . . ?
C18 C17 H17A 108.8 . . ?
C11 C17 H17A 108.8 . . ?
C18 C17 H17B 108.8 . . ?
C11 C17 H17B 108.8 . . ?
H17A C17 H17B 107.7 . . ?
C19 C18 C17 113.6(3) . . ?
C19 C18 H18A 108.8 . . ?
C17 C18 H18A 108.8 . . ?
C19 C18 H18B 108.8 . . ?
C17 C18 H18B 108.8 . . ?
H18A C18 H18B 107.7 . . ?
C20 C19 C20' 20(2) . . ?
C20 C19 C18 134.3(9) . . ?
C20' C19 C18 114.7(14) . . ?
C20 C19 H19 112.9 . . ?
C20' C19 H19 132.4 . . ?
C18 C19 H19 112.9 . . ?
C20 C19 H19' 103.6 . . ?
C20' C19 H19' 123.2 . . ?
C18 C19 H19' 122.1 . . ?
H19 C19 H19' 9.4 . . ?
C19 C20 H20A 120.0 . . ?
C19 C20 H20B 120.0 . . ?
H20A C20 H20B 120.0 . . ?
C19 C20' H20C 120.0 . . ?
C19 C20' H20D 120.0 . . ?
H20C C20' H20D 120.0 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
O1 C1 C2 C11 39.4(4) . . . . ?
C6 C1 C2 C11 -144.4(2) . . . . ?
O1 C1 C2 C3 -97.1(3) . . . . ?
C6 C1 C2 C3 79.0(3) . . . . ?
C1 C2 C3 C4 -51.2(3) . . . . ?
C11 C2 C3 C4 179.5(2) . . . . ?
C2 C3 C4 C12 167.1(3) . . . . ?
C2 C3 C4 C5 -9.9(4) . . . . ?
C12 C4 C5 C6 -122.1(4) . . . . ?
C3 C4 C5 C6 54.9(3) . . . . ?
O1 C1 C6 C5 141.9(3) . . . . ?
C2 C1 C6 C5 -34.2(3) . . . . ?
O1 C1 C6 C7 -93.7(3) . . . . ?
C2 C1 C6 C7 90.2(2) . . . . ?
C4 C5 C6 C1 -30.4(3) . . . . ?
C4 C5 C6 C7 -150.7(2) . . . . ?
C1 C6 C7 C8 -43.1(3) . . . . ?
C5 C6 C7 C8 77.4(3) . . . . ?
C1 C6 C7 C13 84.9(3) . . . . ?
C5 C6 C7 C13 -154.6(2) . . . . ?
C13 C7 C8 C9 -57.1(3) . . . . ?
C6 C7 C8 C9 70.3(3) . . . . ?
C7 C8 C9 C10 -117.7(3) . . . . ?
C8 C9 C10 C16 -159.3(3) . . . . ?
C8 C9 C10 C11 76.2(3) . . . . ?
C1 C2 C11 C17 -158.7(2) . . . . ?
C3 C2 C11 C17 -33.7(4) . . . . ?
C1 C2 C11 C10 77.7(3) . . . . ?
C3 C2 C11 C10 -157.3(3) . . . . ?
C16 C10 C11 C2 -163.7(3) . . . . ?
C9 C10 C11 C2 -40.5(3) . . . . ?
C16 C10 C11 C17 71.3(3) . . . . ?
C9 C10 C11 C17 -165.6(3) . . . . ?
C8 C7 C13 C14 -167.8(3) . . . . ?
C6 C7 C13 C14 63.3(3) . . . . ?
C8 C7 C13 C15 -45.1(3) . . . . ?
C6 C7 C13 C15 -174.0(3) . . . . ?
C2 C11 C17 C18 89.3(3) . . . . ?
C10 C11 C17 C18 -149.3(3) . . . . ?
C11 C17 C18 C19 177.8(3) . . . . ?
C17 C18 C19 C20 126(3) . . . . ?
C17 C18 C19 C20' 124(3) . . . . ?

_diffrn_measured_fraction_theta_max 0.994
_diffrn_reflns_theta_full        25.50
_diffrn_measured_fraction_theta_full 0.994
_refine_diff_density_max         0.272
_refine_diff_density_min         -0.251
_refine_diff_density_rms         0.053
_database_code_depnum_ccdc_archive 'CCDC 980194'
