# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2014

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#                                CCDC 
# 
#######################################################################
# 
#  This CIF contains data from an original supplementary publication
#  deposited with the CCDC, and may include chemical, crystal,
#  experimental, refinement, atomic coordinates,
#  anisotropic displacement parameters and molecular geometry data,
#  as required by the journal to which it was submitted.
#
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#  fide research purposes only. It may contain copyright material
#  of the CCDC or of third parties, and may not be copied or further
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#  except for the purpose of generating routine backup copies
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#  data retrieval see:
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data_zp_jf01

_audit_creation_method           SHELXL-97
_chemical_name_systematic        ?
_chemical_name_common            ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C29 H46 O4'
_chemical_melting_point          ?

_exptl_crystal_description       ?
_exptl_crystal_colour            colorless

_diffrn_ambient_temperature      100.0(2)
_chemical_formula_weight         456.66

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           monoclinic
_symmetry_space_group_name_H-M   'P 21'
_symmetry_int_tables_number      4
_chemical_absolute_configuration rmad

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, y+1/2, -z'

_cell_length_a                   11.4050(2)
_cell_length_b                   6.18540(10)
_cell_length_c                   18.2916(3)
_cell_angle_alpha                90.00
_cell_angle_beta                 90.4610(10)
_cell_angle_gamma                90.00
_cell_volume                     1290.33(4)
_cell_formula_units_Z            2
_cell_measurement_temperature    100.0(2)
_cell_measurement_reflns_used    ?
_cell_measurement_theta_min      ?
_cell_measurement_theta_max      ?
_exptl_crystal_size_max          1.0
_exptl_crystal_size_mid          0.1
_exptl_crystal_size_min          0.1
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.121
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             460
_exptl_absorpt_coefficient_mu    0.621
_exptl_absorpt_correction_type   none
_exptl_absorpt_correction_T_min  ?
_exptl_absorpt_correction_T_max  ?
_exptl_absorpt_process_details   ?

_exptl_special_details           
;
?
;
_diffrn_radiation_probe          x-ray
_diffrn_radiation_type           CuK\a
_diffrn_radiation_wavelength     1.54184
_diffrn_source                   'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  ?
_diffrn_measurement_method       ?
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            4443
_diffrn_reflns_av_R_equivalents  0.0160
_diffrn_reflns_av_sigmaI/netI    0.0281
_diffrn_reflns_limit_h_min       -13
_diffrn_reflns_limit_h_max       12
_diffrn_reflns_limit_k_min       -3
_diffrn_reflns_limit_k_max       7
_diffrn_reflns_limit_l_min       -20
_diffrn_reflns_limit_l_max       22
_diffrn_reflns_theta_min         3.88
_diffrn_reflns_theta_max         71.75
_reflns_number_total             3395
_reflns_number_gt                3307
_reflns_threshold_expression     >2σ(I)

_computing_data_collection       'CrysAlis PRO (Agilent, 2011)'
_computing_cell_refinement       'CrysAlis PRO (Agilent, 2011)'
_computing_data_reduction        'CrysAlis PRO (Agilent, 2011)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 2008)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 2008)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
;
Refinement of F² against ALL reflections. The weighted R-factor wR and
goodness of fit S are based on F², conventional R-factors R are based
on F, with F set to zero for negative F². The threshold expression of
F² > 2σ(F²) is used only for calculating R-factors(gt) etc. and is
not relevant to the choice of reflections for refinement. R-factors based
on F² are statistically about twice as large as those based on F, and R-
factors based on ALL data will be even larger.
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0450P)²+0.1514P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   0.15(15)
_refine_ls_number_reflns         3395
_refine_ls_number_parameters     305
_refine_ls_number_restraints     1
_refine_ls_R_factor_all          0.0305
_refine_ls_R_factor_gt           0.0297
_refine_ls_wR_factor_ref         0.0770
_refine_ls_wR_factor_gt          0.0761
_refine_ls_goodness_of_fit_ref   1.075
_refine_ls_restrained_S_all      1.075
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
O1 O -0.66570(11) -0.9755(2) -0.48597(6) 0.0275(3) Uani 1 1 d . . .
O2 O -0.65267(9) -0.6208(2) -0.45824(5) 0.0195(2) Uani 1 1 d . . .
O4 O -0.93650(8) -0.02872(19) -0.04834(5) 0.0162(2) Uani 1 1 d . . .
O3 O -0.84942(9) -0.79084(19) -0.16921(5) 0.0178(2) Uani 1 1 d . . .
H3O H -0.8714 -0.8485 -0.1314 0.027 Uiso 1 1 calc R . .
C1 C -0.69844(13) -0.6640(3) -0.38558(7) 0.0175(3) Uani 1 1 d . . .
H1 H -0.7566 -0.7804 -0.3885 0.021 Uiso 1 1 calc R . .
C2 C -0.59817(12) -0.7326(3) -0.33531(8) 0.0182(3) Uani 1 1 d . . .
H2A H -0.5377 -0.6223 -0.3353 0.022 Uiso 1 1 calc R . .
H2B H -0.5641 -0.8660 -0.3531 0.022 Uiso 1 1 calc R . .
C3 C -0.64250(12) -0.7659(3) -0.25728(7) 0.0166(3) Uani 1 1 d . . .
H3A H -0.5765 -0.8012 -0.2257 0.020 Uiso 1 1 calc R . .
H3B H -0.6961 -0.8876 -0.2568 0.020 Uiso 1 1 calc R . .
C4 C -0.70541(12) -0.5656(3) -0.22660(7) 0.0139(3) Uani 1 1 d . . .
C5 C -0.80389(12) -0.4971(3) -0.28102(7) 0.0148(3) Uani 1 1 d . . .
H5A H -0.8592 -0.6181 -0.2842 0.018 Uiso 1 1 calc R . .
C6 C -0.75670(12) -0.4593(3) -0.35868(7) 0.0171(3) Uani 1 1 d . . .
H6A H -0.8207 -0.4201 -0.3913 0.021 Uiso 1 1 calc R . .
H6B H -0.7004 -0.3417 -0.3581 0.021 Uiso 1 1 calc R . .
C7 C -0.76421(12) -0.6260(3) -0.15197(7) 0.0144(3) Uani 1 1 d . . .
C8 C -0.83165(11) -0.4295(3) -0.12336(7) 0.0138(3) Uani 1 1 d . . .
C9 C -0.92379(12) -0.3476(3) -0.17662(7) 0.0162(3) Uani 1 1 d . . .
H9A H -0.9579 -0.2156 -0.1576 0.019 Uiso 1 1 calc R . .
H9B H -0.9858 -0.4542 -0.1811 0.019 Uiso 1 1 calc R . .
C10 C -0.87236(12) -0.3029(3) -0.25266(7) 0.0162(3) Uani 1 1 d . . .
H10A H -0.9355 -0.2691 -0.2866 0.019 Uiso 1 1 calc R . .
H10B H -0.8208 -0.1783 -0.2499 0.019 Uiso 1 1 calc R . .
C11 C -0.67448(12) -0.7157(3) -0.09679(7) 0.0164(3) Uani 1 1 d . . .
H11A H -0.6640 -0.8690 -0.1058 0.020 Uiso 1 1 calc R . .
H11B H -0.5996 -0.6452 -0.1045 0.020 Uiso 1 1 calc R . .
C12 C -0.71070(12) -0.6834(3) -0.01702(7) 0.0156(3) Uani 1 1 d . . .
H12A H -0.7832 -0.7605 -0.0082 0.019 Uiso 1 1 calc R . .
H12B H -0.6508 -0.7432 0.0150 0.019 Uiso 1 1 calc R . .
C13 C -0.72768(11) -0.4443(3) 0.00070(7) 0.0132(3) Uani 1 1 d . . .
C14 C -0.81300(11) -0.3502(2) -0.05588(7) 0.0131(3) Uani 1 1 d . . .
C15 C -0.79291(11) -0.4030(3) 0.07489(7) 0.0137(3) Uani 1 1 d . . .
H15 H -0.8517 -0.5173 0.0804 0.016 Uiso 1 1 calc R . .
C16 C -0.85900(12) -0.1901(3) 0.06178(7) 0.0144(3) Uani 1 1 d . . .
H16A H -0.9333 -0.1910 0.0873 0.017 Uiso 1 1 calc R . .
H16B H -0.8129 -0.0685 0.0792 0.017 Uiso 1 1 calc R . .
C17 C -0.87900(11) -0.1738(3) -0.01981(7) 0.0137(3) Uani 1 1 d . . .
C18 C -0.63762(13) -0.7943(3) -0.50193(8) 0.0205(3) Uani 1 1 d . . .
C19 C -0.57932(14) -0.7298(3) -0.57198(8) 0.0247(4) Uani 1 1 d . . .
H19A H -0.6003 -0.5836 -0.5839 0.037 Uiso 1 1 calc R . .
H19B H -0.6046 -0.8243 -0.6106 0.037 Uiso 1 1 calc R . .
H19C H -0.4958 -0.7402 -0.5662 0.037 Uiso 1 1 calc R . .
C20 C -0.61626(12) -0.3811(3) -0.21482(7) 0.0169(3) Uani 1 1 d . . .
H20A H -0.6508 -0.2706 -0.1851 0.025 Uiso 1 1 calc R . .
H20B H -0.5950 -0.3211 -0.2613 0.025 Uiso 1 1 calc R . .
H20C H -0.5475 -0.4369 -0.1908 0.025 Uiso 1 1 calc R . .
C21 C -0.61155(11) -0.3180(3) -0.00180(7) 0.0160(3) Uani 1 1 d . . .
H21A H -0.6253 -0.1703 0.0118 0.024 Uiso 1 1 calc R . .
H21B H -0.5807 -0.3230 -0.0504 0.024 Uiso 1 1 calc R . .
H21C H -0.5563 -0.3818 0.0316 0.024 Uiso 1 1 calc R . .
C22 C -0.71854(12) -0.3984(3) 0.14566(7) 0.0168(3) Uani 1 1 d . . .
H22 H -0.6580 -0.2875 0.1398 0.020 Uiso 1 1 calc R . .
C23 C -0.65660(15) -0.6134(3) 0.16060(8) 0.0262(4) Uani 1 1 d . . .
H23A H -0.7136 -0.7273 0.1628 0.039 Uiso 1 1 calc R . .
H23B H -0.6150 -0.6051 0.2064 0.039 Uiso 1 1 calc R . .
H23C H -0.6023 -0.6428 0.1220 0.039 Uiso 1 1 calc R . .
C24 C -0.79430(12) -0.3334(3) 0.21143(7) 0.0184(3) Uani 1 1 d . . .
H24A H -0.8345 -0.1992 0.2000 0.022 Uiso 1 1 calc R . .
H24B H -0.8535 -0.4436 0.2190 0.022 Uiso 1 1 calc R . .
C25 C -0.72443(13) -0.3039(3) 0.28229(7) 0.0230(3) Uani 1 1 d . . .
H25A H -0.6551 -0.2188 0.2720 0.028 Uiso 1 1 calc R . .
H25B H -0.6985 -0.4447 0.2993 0.028 Uiso 1 1 calc R . .
C26 C -0.79238(14) -0.1939(3) 0.34355(8) 0.0234(3) Uani 1 1 d . . .
H26A H -0.8123 -0.0486 0.3278 0.028 Uiso 1 1 calc R . .
H26B H -0.7408 -0.1809 0.3858 0.028 Uiso 1 1 calc R . .
C27 C -0.90495(13) -0.3065(3) 0.36766(8) 0.0217(3) Uani 1 1 d . . .
H27 H -0.9604 -0.3055 0.3265 0.026 Uiso 1 1 calc R . .
C28 C -0.88485(16) -0.5396(3) 0.39060(9) 0.0293(4) Uani 1 1 d . . .
H28A H -0.8313 -0.5437 0.4313 0.044 Uiso 1 1 calc R . .
H28B H -0.8525 -0.6191 0.3505 0.044 Uiso 1 1 calc R . .
H28C H -0.9581 -0.6034 0.4045 0.044 Uiso 1 1 calc R . .
C29 C -0.95926(15) -0.1799(4) 0.43070(9) 0.0323(4) Uani 1 1 d . . .
H29A H -1.0329 -0.2441 0.4435 0.048 Uiso 1 1 calc R . .
H29B H -0.9717 -0.0327 0.4159 0.048 Uiso 1 1 calc R . .
H29C H -0.9073 -0.1835 0.4722 0.048 Uiso 1 1 calc R . .


_geom_special_details            
;
All s.u.'s (except the s.u. in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell s.u.'s are taken
into account individually in the estimation of s.u.'s in distances, angles
and torsion angles; correlations between s.u.'s in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell s.u.'s is used for estimating s.u.'s involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
O1 C18 1.202(2) . ?
O2 C18 1.350(2) . ?
O2 C1 1.4565(15) . ?
O4 C17 1.2255(19) . ?
O3 C7 1.4417(18) . ?
C1 C6 1.514(2) . ?
C1 C2 1.5218(19) . ?
C2 C3 1.5320(18) . ?
C3 C4 1.540(2) . ?
C4 C20 1.542(2) . ?
C4 C5 1.5538(18) . ?
C4 C7 1.5707(17) . ?
C5 C10 1.526(2) . ?
C5 C6 1.5409(18) . ?
C7 C8 1.533(2) . ?
C7 C11 1.5354(18) . ?
C8 C14 1.344(2) . ?
C8 C9 1.5143(18) . ?
C9 C10 1.5389(18) . ?
C11 C12 1.5329(17) . ?
C12 C13 1.526(2) . ?
C13 C14 1.5299(18) . ?
C13 C21 1.5387(19) . ?
C13 C15 1.5737(17) . ?
C14 C17 1.483(2) . ?
C15 C16 1.535(2) . ?
C15 C22 1.5422(17) . ?
C16 C17 1.5114(17) . ?
C18 C19 1.502(2) . ?
C22 C23 1.530(2) . ?
C22 C24 1.5402(18) . ?
C24 C25 1.5269(18) . ?
C25 C26 1.528(2) . ?
C26 C27 1.529(2) . ?
C27 C28 1.519(3) . ?
C27 C29 1.529(2) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C18 O2 C1 116.25(13) . . ?
O2 C1 C6 107.72(12) . . ?
O2 C1 C2 109.23(11) . . ?
C6 C1 C2 111.48(12) . . ?
C1 C2 C3 110.39(11) . . ?
C2 C3 C4 112.94(12) . . ?
C3 C4 C20 109.73(11) . . ?
C3 C4 C5 108.81(11) . . ?
C20 C4 C5 111.10(12) . . ?
C3 C4 C7 109.21(12) . . ?
C20 C4 C7 109.88(11) . . ?
C5 C4 C7 108.07(10) . . ?
C10 C5 C6 112.17(12) . . ?
C10 C5 C4 111.48(11) . . ?
C6 C5 C4 112.08(11) . . ?
C1 C6 C5 109.28(12) . . ?
O3 C7 C8 107.24(11) . . ?
O3 C7 C11 109.43(13) . . ?
C8 C7 C11 113.32(11) . . ?
O3 C7 C4 105.65(11) . . ?
C8 C7 C4 109.09(12) . . ?
C11 C7 C4 111.73(11) . . ?
C14 C8 C9 124.96(13) . . ?
C14 C8 C7 121.80(13) . . ?
C9 C8 C7 113.14(12) . . ?
C8 C9 C10 111.97(11) . . ?
C5 C10 C9 111.43(12) . . ?
C12 C11 C7 113.28(11) . . ?
C13 C12 C11 111.36(12) . . ?
C12 C13 C14 107.83(11) . . ?
C12 C13 C21 112.02(12) . . ?
C14 C13 C21 109.24(12) . . ?
C12 C13 C15 113.72(12) . . ?
C14 C13 C15 102.64(11) . . ?
C21 C13 C15 110.86(11) . . ?
C8 C14 C17 126.86(13) . . ?
C8 C14 C13 125.29(13) . . ?
C17 C14 C13 107.54(11) . . ?
C16 C15 C22 112.41(12) . . ?
C16 C15 C13 103.87(11) . . ?
C22 C15 C13 117.79(11) . . ?
C17 C16 C15 106.34(12) . . ?
O4 C17 C14 128.38(12) . . ?
O4 C17 C16 123.05(14) . . ?
C14 C17 C16 108.48(12) . . ?
O1 C18 O2 124.20(13) . . ?
O1 C18 C19 125.12(15) . . ?
O2 C18 C19 110.67(15) . . ?
C23 C22 C24 110.40(13) . . ?
C23 C22 C15 112.58(13) . . ?
C24 C22 C15 110.63(11) . . ?
C25 C24 C22 113.70(12) . . ?
C24 C25 C26 114.30(13) . . ?
C25 C26 C27 116.16(15) . . ?
C28 C27 C26 112.77(14) . . ?
C28 C27 C29 109.82(14) . . ?
C26 C27 C29 109.30(15) . . ?

_diffrn_measured_fraction_theta_max 0.981
_diffrn_reflns_theta_full        71.75
_diffrn_measured_fraction_theta_full 0.981
_refine_diff_density_max         0.150
_refine_diff_density_min         -0.200
_refine_diff_density_rms         0.044



_database_code_depnum_ccdc_archive 'CCDC 882503'
