# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2014

#######################################################################
#
#                 Cambridge Crystallographic Data Centre
#                                CCDC 
# 
#######################################################################
# 
#  This CIF contains data from an original supplementary publication
#  deposited with the CCDC, and may include chemical, crystal,
#  experimental, refinement, atomic coordinates,
#  anisotropic displacement parameters and molecular geometry data,
#  as required by the journal to which it was submitted.
#
#  This CIF is provided on the understanding that it is used for bona
#  fide research purposes only. It may contain copyright material
#  of the CCDC or of third parties, and may not be copied or further
#  disseminated in any form, whether machine-readable or not,
#  except for the purpose of generating routine backup copies
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#  data retrieval see:
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#  from this site to visualise CIF-encoded structures and 
#  to carry out CIF format checking respectively.
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data_4g

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C19 H19 Cl N2 O'
_chemical_formula_weight         326.81

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Orthorhombic
_symmetry_space_group_name_H-M   P2(1)2(1)2(1)

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x+1/2, -y, z+1/2'
'-x, y+1/2, -z+1/2'
'x+1/2, -y+1/2, -z'

_cell_length_a                   7.2494(19)
_cell_length_b                   13.352(4)
_cell_length_c                   16.888(5)
_cell_angle_alpha                90.00
_cell_angle_beta                 90.00
_cell_angle_gamma                90.00
_cell_volume                     1634.7(7)
_cell_formula_units_Z            4
_cell_measurement_temperature    143(2)
_cell_measurement_reflns_used    6852
_cell_measurement_theta_min      2.412
_cell_measurement_theta_max      31.502

_exptl_crystal_description       Block
_exptl_crystal_colour            Colorless
_exptl_crystal_size_max          0.51
_exptl_crystal_size_mid          0.50
_exptl_crystal_size_min          0.50
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.328
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             688
_exptl_absorpt_coefficient_mu    0.240
_exptl_absorpt_correction_type   Multi-scans
_exptl_absorpt_correction_T_min  0.8875
_exptl_absorpt_correction_T_max  0.8895
_exptl_absorpt_process_details   ?

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      143(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'Rotating Anode'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  AFC10/Saturn724+
_diffrn_measurement_method       'phi and omega scans'
_diffrn_detector_area_resol_mean 28.5714
_diffrn_standards_number         0
_diffrn_standards_interval_count 0
_diffrn_standards_interval_time  0
_diffrn_standards_decay_%        0
_diffrn_reflns_number            16028
_diffrn_reflns_av_R_equivalents  0.0622
_diffrn_reflns_av_sigmaI/netI    0.0859
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_k_min       -19
_diffrn_reflns_limit_k_max       15
_diffrn_reflns_limit_l_min       -24
_diffrn_reflns_limit_l_max       24
_diffrn_reflns_theta_min         3.06
_diffrn_reflns_theta_max         31.53
_reflns_number_total             5405
_reflns_number_gt                4607
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'CrystalClear (Rigaku Inc., 2008)'
_computing_cell_refinement       'CrystalClear (Rigaku Inc., 2008)'
_computing_data_reduction        'CrystalClear (Rigaku Inc., 2008)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0638P)²+0.1160P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     SHELXL
_refine_ls_extinction_coef       0.024(3)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4^
_chemical_absolute_configuration ad
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   0.10(8)
_refine_ls_number_reflns         5405
_refine_ls_number_parameters     222
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0652
_refine_ls_R_factor_gt           0.0579
_refine_ls_wR_factor_ref         0.1455
_refine_ls_wR_factor_gt          0.1405
_refine_ls_goodness_of_fit_ref   1.002
_refine_ls_restrained_S_all      1.002
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
Cl1 Cl 0.79654(9) 0.79579(4) 0.67298(3) 0.02898(16) Uani 1 1 d . B .
N1 N 0.2265(4) 0.85351(17) 0.54333(13) 0.0383(6) Uani 1 1 d . . .
N2 N 0.2628(5) 0.74723(19) 0.78913(13) 0.0531(9) Uani 1 1 d . . .
C1 C 0.4070(3) 0.46916(17) 0.65204(12) 0.0187(4) Uani 1 1 d . B .
H1 H 0.4029 0.4010 0.6765 0.022 Uiso 1 1 calc R . .
C2 C 0.4360(3) 0.45459(17) 0.56112(12) 0.0189(4) Uani 1 1 d . . .
H2 H 0.5213 0.5090 0.5433 0.023 Uiso 1 1 calc R A 1
C3 C 0.2511(3) 0.47105(18) 0.51729(12) 0.0222(5) Uani 1 1 d . B .
C4 C 0.0954(4) 0.4107(2) 0.55596(16) 0.0323(6) Uani 1 1 d . . .
H4A H 0.1280 0.3387 0.5558 0.039 Uiso 1 1 calc R B .
H4B H -0.0195 0.4192 0.5250 0.039 Uiso 1 1 calc R . .
C5 C 0.0629(4) 0.44560(19) 0.64181(14) 0.0266(5) Uani 1 1 d . B .
H5A H 0.0626 0.3869 0.6777 0.032 Uiso 1 1 calc R . .
H5B H -0.0588 0.4789 0.6458 0.032 Uiso 1 1 calc R . .
C6 C 0.2159(3) 0.51913(16) 0.66705(12) 0.0203(4) Uani 1 1 d . . .
H6 H 0.2019 0.5385 0.7239 0.024 Uiso 1 1 calc R B .
C7 C 0.2070(3) 0.60916(17) 0.61460(12) 0.0198(4) Uani 1 1 d . B .
C8 C 0.2008(4) 0.58271(18) 0.52821(12) 0.0253(5) Uani 1 1 d . . .
H8A H 0.2891 0.6250 0.4986 0.030 Uiso 1 1 calc R B .
H8B H 0.0756 0.5954 0.5070 0.030 Uiso 1 1 calc R . .
C9 C 0.2659(4) 0.4482(2) 0.42865(13) 0.0338(6) Uani 1 1 d . . .
H9A H 0.1505 0.4668 0.4023 0.041 Uiso 1 1 calc R B .
H9B H 0.2887 0.3764 0.4211 0.041 Uiso 1 1 calc R . .
H9C H 0.3681 0.4866 0.4058 0.041 Uiso 1 1 calc R . .
C10 C 0.5554(3) 0.52743(17) 0.69421(12) 0.0200(4) Uani 1 1 d . . .
C11 C 0.6136(4) 0.49831(18) 0.77027(13) 0.0232(5) Uani 1 1 d . B .
H11 H 0.5695 0.4373 0.7921 0.028 Uiso 1 1 calc R . .
C12 C 0.7341(4) 0.5569(2) 0.81388(13) 0.0300(5) Uani 1 1 d . . .
H12 H 0.7762 0.5343 0.8640 0.036 Uiso 1 1 calc R B .
C13 C 0.7937(4) 0.6488(2) 0.78470(13) 0.0296(5) Uani 1 1 d . B .
H13 H 0.8720 0.6907 0.8153 0.035 Uiso 1 1 calc R . .
C14 C 0.7358(3) 0.67773(18) 0.70981(13) 0.0235(5) Uani 1 1 d . . .
C15 C 0.6244(3) 0.61780(16) 0.66359(12) 0.0208(4) Uani 1 1 d . B .
H15 H 0.5944 0.6376 0.6111 0.025 Uiso 1 1 calc R . .
C17 C 0.2191(3) 0.70418(18) 0.64105(12) 0.0236(4) Uani 1 1 d . . .
C18 C 0.2225(4) 0.78733(18) 0.58706(13) 0.0261(5) Uani 1 1 d . B .
C19 C 0.2419(4) 0.72851(18) 0.72391(14) 0.0316(6) Uani 1 1 d . B .
C16 C 0.5360(3) 0.35521(18) 0.54639(13) 0.0236(5) Uani 0.563(5) 1 d P B 1
H16A H 0.5585 0.3475 0.4889 0.028 Uiso 0.563(5) 1 calc PR B 1
H16B H 0.6572 0.3567 0.5734 0.028 Uiso 0.563(5) 1 calc PR B 1
O1 O 0.4324(5) 0.2708(2) 0.57443(18) 0.0286(9) Uani 0.563(5) 1 d P B 1
H1O H 0.4680 0.2555 0.6202 0.034 Uiso 0.563(5) 1 calc PR B 1
C16' C 0.5360(3) 0.35521(18) 0.54639(13) 0.0236(5) Uani 0.437(5) 1 d P B 2
H16C H 0.6303 0.3446 0.5879 0.028 Uiso 0.437(5) 1 calc PR B 2
H16D H 0.4465 0.2993 0.5492 0.028 Uiso 0.437(5) 1 calc PR B 2
O1' O 0.6225(7) 0.3560(3) 0.4702(2) 0.0334(12) Uani 0.437(5) 1 d P B 2
H1'O H 0.7277 0.3300 0.4736 0.040 Uiso 0.437(5) 1 calc PR B 2


_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
Cl1 C14 1.751(2) . ?
N1 C18 1.152(3) . ?
N2 C19 1.140(3) . ?
C1 C10 1.507(3) . ?
C1 C6 1.558(3) . ?
C1 C2 1.562(3) . ?
C1 H1 1.0000 . ?
C2 C16 1.532(3) . ?
C2 C3 1.547(3) . ?
C2 H2 1.0000 . ?
C3 C9 1.532(3) . ?
C3 C4 1.533(3) . ?
C3 C8 1.546(3) . ?
C4 C5 1.541(3) . ?
C4 H4A 0.9900 . ?
C4 H4B 0.9900 . ?
C5 C6 1.541(3) . ?
C5 H5A 0.9900 . ?
C5 H5B 0.9900 . ?
C6 C7 1.495(3) . ?
C6 H6 1.0000 . ?
C7 C17 1.348(3) . ?
C7 C8 1.502(3) . ?
C8 H8A 0.9900 . ?
C8 H8B 0.9900 . ?
C9 H9A 0.9800 . ?
C9 H9B 0.9800 . ?
C9 H9C 0.9800 . ?
C10 C15 1.405(3) . ?
C10 C11 1.407(3) . ?
C11 C12 1.385(3) . ?
C11 H11 0.9500 . ?
C12 C13 1.391(3) . ?
C12 H12 0.9500 . ?
C13 C14 1.387(3) . ?
C13 H13 0.9500 . ?
C14 C15 1.379(3) . ?
C15 H15 0.9500 . ?
C17 C18 1.437(3) . ?
C17 C19 1.446(3) . ?
C16 O1 1.435(4) . ?
C16 H16A 0.9900 . ?
C16 H16B 0.9900 . ?
O1 H1O 0.8400 . ?
O1' H1'O 0.8400 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C10 C1 C6 109.68(18) . . ?
C10 C1 C2 115.65(18) . . ?
C6 C1 C2 109.46(17) . . ?
C10 C1 H1 107.2 . . ?
C6 C1 H1 107.2 . . ?
C2 C1 H1 107.2 . . ?
C16 C2 C3 117.07(19) . . ?
C16 C2 C1 109.35(17) . . ?
C3 C2 C1 109.61(17) . . ?
C16 C2 H2 106.8 . . ?
C3 C2 H2 106.8 . . ?
C1 C2 H2 106.8 . . ?
C9 C3 C4 111.3(2) . . ?
C9 C3 C8 109.00(19) . . ?
C4 C3 C8 106.4(2) . . ?
C9 C3 C2 112.21(19) . . ?
C4 C3 C2 111.07(19) . . ?
C8 C3 C2 106.51(18) . . ?
C3 C4 C5 110.7(2) . . ?
C3 C4 H4A 109.5 . . ?
C5 C4 H4A 109.5 . . ?
C3 C4 H4B 109.5 . . ?
C5 C4 H4B 109.5 . . ?
H4A C4 H4B 108.1 . . ?
C4 C5 C6 110.07(19) . . ?
C4 C5 H5A 109.6 . . ?
C6 C5 H5A 109.6 . . ?
C4 C5 H5B 109.6 . . ?
C6 C5 H5B 109.6 . . ?
H5A C5 H5B 108.2 . . ?
C7 C6 C5 108.50(18) . . ?
C7 C6 C1 106.64(18) . . ?
C5 C6 C1 108.78(18) . . ?
C7 C6 H6 110.9 . . ?
C5 C6 H6 110.9 . . ?
C1 C6 H6 110.9 . . ?
C17 C7 C6 123.90(19) . . ?
C17 C7 C8 123.04(19) . . ?
C6 C7 C8 112.82(18) . . ?
C7 C8 C3 109.61(18) . . ?
C7 C8 H8A 109.7 . . ?
C3 C8 H8A 109.7 . . ?
C7 C8 H8B 109.7 . . ?
C3 C8 H8B 109.7 . . ?
H8A C8 H8B 108.2 . . ?
C3 C9 H9A 109.5 . . ?
C3 C9 H9B 109.5 . . ?
H9A C9 H9B 109.5 . . ?
C3 C9 H9C 109.5 . . ?
H9A C9 H9C 109.5 . . ?
H9B C9 H9C 109.5 . . ?
C15 C10 C11 117.8(2) . . ?
C15 C10 C1 121.59(19) . . ?
C11 C10 C1 120.2(2) . . ?
C12 C11 C10 121.2(2) . . ?
C12 C11 H11 119.4 . . ?
C10 C11 H11 119.4 . . ?
C11 C12 C13 120.4(2) . . ?
C11 C12 H12 119.8 . . ?
C13 C12 H12 119.8 . . ?
C14 C13 C12 118.3(2) . . ?
C14 C13 H13 120.8 . . ?
C12 C13 H13 120.8 . . ?
C15 C14 C13 122.1(2) . . ?
C15 C14 Cl1 117.94(17) . . ?
C13 C14 Cl1 119.91(19) . . ?
C14 C15 C10 119.9(2) . . ?
C14 C15 H15 120.0 . . ?
C10 C15 H15 120.0 . . ?
C7 C17 C18 121.20(19) . . ?
C7 C17 C19 122.7(2) . . ?
C18 C17 C19 116.0(2) . . ?
N1 C18 C17 179.3(3) . . ?
N2 C19 C17 178.9(4) . . ?
O1 C16 C2 112.3(2) . . ?
O1 C16 H16A 109.1 . . ?
C2 C16 H16A 109.1 . . ?
O1 C16 H16B 109.1 . . ?
C2 C16 H16B 109.1 . . ?
H16A C16 H16B 107.9 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C10 C1 C2 C16 92.9(2) . . . . ?
C6 C1 C2 C16 -142.64(19) . . . . ?
C10 C1 C2 C3 -137.5(2) . . . . ?
C6 C1 C2 C3 -13.1(2) . . . . ?
C16 C2 C3 C9 -49.4(3) . . . . ?
C1 C2 C3 C9 -174.60(19) . . . . ?
C16 C2 C3 C4 75.9(2) . . . . ?
C1 C2 C3 C4 -49.3(2) . . . . ?
C16 C2 C3 C8 -168.56(18) . . . . ?
C1 C2 C3 C8 66.2(2) . . . . ?
C9 C3 C4 C5 -171.6(2) . . . . ?
C8 C3 C4 C5 -53.0(3) . . . . ?
C2 C3 C4 C5 62.6(3) . . . . ?
C3 C4 C5 C6 -8.7(3) . . . . ?
C4 C5 C6 C7 62.1(3) . . . . ?
C4 C5 C6 C1 -53.5(2) . . . . ?
C10 C1 C6 C7 77.1(2) . . . . ?
C2 C1 C6 C7 -50.7(2) . . . . ?
C10 C1 C6 C5 -166.02(18) . . . . ?
C2 C1 C6 C5 66.1(2) . . . . ?
C5 C6 C7 C17 135.5(2) . . . . ?
C1 C6 C7 C17 -107.5(3) . . . . ?
C5 C6 C7 C8 -49.9(3) . . . . ?
C1 C6 C7 C8 67.1(2) . . . . ?
C17 C7 C8 C3 161.5(2) . . . . ?
C6 C7 C8 C3 -13.1(3) . . . . ?
C9 C3 C8 C7 -173.6(2) . . . . ?
C4 C3 C8 C7 66.3(3) . . . . ?
C2 C3 C8 C7 -52.3(2) . . . . ?
C6 C1 C10 C15 -77.9(2) . . . . ?
C2 C1 C10 C15 46.4(3) . . . . ?
C6 C1 C10 C11 94.7(2) . . . . ?
C2 C1 C10 C11 -140.9(2) . . . . ?
C15 C10 C11 C12 0.4(4) . . . . ?
C1 C10 C11 C12 -172.5(2) . . . . ?
C10 C11 C12 C13 3.0(4) . . . . ?
C11 C12 C13 C14 -2.8(4) . . . . ?
C12 C13 C14 C15 -1.0(4) . . . . ?
C12 C13 C14 Cl1 176.3(2) . . . . ?
C13 C14 C15 C10 4.5(4) . . . . ?
Cl1 C14 C15 C10 -172.92(17) . . . . ?
C11 C10 C15 C14 -4.1(3) . . . . ?
C1 C10 C15 C14 168.8(2) . . . . ?
C6 C7 C17 C18 175.6(2) . . . . ?
C8 C7 C17 C18 1.5(4) . . . . ?
C6 C7 C17 C19 -0.1(4) . . . . ?
C8 C7 C17 C19 -174.2(2) . . . . ?
C7 C17 C18 N1 -46(29) . . . . ?
C19 C17 C18 N1 130(29) . . . . ?
C7 C17 C19 N2 76(15) . . . . ?
C18 C17 C19 N2 -100(15) . . . . ?
C3 C2 C16 O1 -64.3(3) . . . . ?
C1 C2 C16 O1 61.0(3) . . . . ?

_diffrn_measured_fraction_theta_max 0.995
_diffrn_reflns_theta_full        31.53
_diffrn_measured_fraction_theta_full 0.995
_refine_diff_density_max         0.283
_refine_diff_density_min         -0.271
_refine_diff_density_rms         0.061
_database_code_depnum_ccdc_archive 'CCDC 1009387'
