# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2014

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#                                CCDC 
# 
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# 
#  This CIF contains data from an original supplementary publication
#  deposited with the CCDC, and may include chemical, crystal,
#  experimental, refinement, atomic coordinates,
#  anisotropic displacement parameters and molecular geometry data,
#  as required by the journal to which it was submitted.
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#  fide research purposes only. It may contain copyright material
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data_tfepoxy

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C16 H28 N2 O5'
_chemical_formula_weight         328.40

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           ?
_symmetry_space_group_name_H-M   ?

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x+1/2, -y, z+1/2'
'-x, y+1/2, -z+1/2'
'x+1/2, -y+1/2, -z'

_cell_length_a                   5.0614(19)
_cell_length_b                   17.562(6)
_cell_length_c                   19.408(8)
_cell_angle_alpha                90.00
_cell_angle_beta                 90.00
_cell_angle_gamma                90.00
_cell_volume                     1725.1(12)
_cell_formula_units_Z            4
_cell_measurement_temperature    296(2)
_cell_measurement_reflns_used    ?
_cell_measurement_theta_min      ?
_cell_measurement_theta_max      ?

_exptl_crystal_description       needles
_exptl_crystal_colour            clourless
_exptl_crystal_size_max          0.150
_exptl_crystal_size_mid          0.110
_exptl_crystal_size_min          0.008
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.264
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             712
_exptl_absorpt_coefficient_mu    0.093
_exptl_absorpt_correction_type   ?
_exptl_absorpt_correction_T_min  0.988
_exptl_absorpt_correction_T_max  0.999
_exptl_absorpt_process_details   SADABS

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      296(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  ?
_diffrn_measurement_method       ?
_diffrn_detector_area_resol_mean ?
_diffrn_reflns_number            7277
_diffrn_reflns_av_R_equivalents  0.0658
_diffrn_reflns_av_sigmaI/netI    0.1130
_diffrn_reflns_limit_h_min       -5
_diffrn_reflns_limit_h_max       6
_diffrn_reflns_limit_k_min       -21
_diffrn_reflns_limit_k_max       22
_diffrn_reflns_limit_l_min       -9
_diffrn_reflns_limit_l_max       25
_diffrn_reflns_theta_min         2.32
_diffrn_reflns_theta_max         28.64
_reflns_number_total             3998
_reflns_number_gt                1939
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       ?
_computing_cell_refinement       ?
_computing_data_reduction        ?
_computing_structure_solution    'SHELXS-97 (Sheldrick, 2008)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 2008)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.1785P)²+0.0000P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    mixed
_refine_ls_extinction_method     SHELXL
_refine_ls_extinction_coef       0.022(8)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4^
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   0(3)
_refine_ls_number_reflns         3998
_refine_ls_number_parameters     215
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.1696
_refine_ls_R_factor_gt           0.0967
_refine_ls_wR_factor_ref         0.3175
_refine_ls_wR_factor_gt          0.2631
_refine_ls_goodness_of_fit_ref   1.016
_refine_ls_restrained_S_all      1.016
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
C1 C 0.3646(9) 0.3978(2) 0.6333(3) 0.0434(11) Uani 1 1 d . . .
H1 H 0.1899 0.3934 0.6547 0.052 Uiso 1 1 calc R . .
C13 C 0.1413(10) 0.6616(3) 0.6174(4) 0.0584(15) Uani 1 1 d . . .
C7 C 0.7354(10) 0.4211(3) 0.7867(3) 0.0547(13) Uani 1 1 d . . .
C6 C 0.5578(10) 0.3669(3) 0.6822(3) 0.0473(12) Uani 1 1 d . . .
H6 H 0.7357 0.3762 0.6641 0.057 Uiso 1 1 calc R . .
C12 C 0.2179(9) 0.5262(3) 0.6193(3) 0.0464(12) Uani 1 1 d . . .
C2 C 0.3597(14) 0.3533(3) 0.5712(4) 0.0680(17) Uani 1 1 d . . .
H2 H 0.2204 0.3681 0.5388 0.082 Uiso 1 1 calc R . .
C15 C -0.0322(14) 0.6609(4) 0.5583(4) 0.0757(19) Uani 1 1 d . . .
H15A H 0.0670 0.6477 0.5179 0.114 Uiso 1 1 calc R . .
H15B H -0.1090 0.7104 0.5524 0.114 Uiso 1 1 calc R . .
H15C H -0.1698 0.6241 0.5654 0.114 Uiso 1 1 calc R . .
C16 C 0.3233(12) 0.7246(3) 0.6157(4) 0.075(2) Uani 1 1 d . . .
H16A H 0.4586 0.7170 0.6497 0.113 Uiso 1 1 calc R . .
H16B H 0.2302 0.7710 0.6254 0.113 Uiso 1 1 calc R . .
H16C H 0.4025 0.7278 0.5708 0.113 Uiso 1 1 calc R . .
C14 C -0.0040(14) 0.6615(4) 0.6816(4) 0.0738(18) Uani 1 1 d . . .
H14A H -0.1329 0.6214 0.6809 0.111 Uiso 1 1 calc R . .
H14B H -0.0915 0.7096 0.6874 0.111 Uiso 1 1 calc R . .
H14C H 0.1160 0.6534 0.7192 0.111 Uiso 1 1 calc R . .
C5 C 0.5215(16) 0.2828(3) 0.6914(4) 0.0769(19) Uani 1 1 d . . .
H5A H 0.6506 0.2645 0.7245 0.092 Uiso 1 1 calc R . .
H5B H 0.3473 0.2734 0.7105 0.092 Uiso 1 1 calc R . .
C4 C 0.5486(18) 0.2406(3) 0.6293(5) 0.095(3) Uani 1 1 d . . .
H4A H 0.4732 0.1904 0.6362 0.114 Uiso 1 1 calc R . .
H4B H 0.7353 0.2340 0.6197 0.114 Uiso 1 1 calc R . .
C3 C 0.4238(17) 0.2750(3) 0.5690(5) 0.088(2) Uani 1 1 d . . .
H3 H 0.3285 0.2421 0.5367 0.105 Uiso 1 1 calc R . .
N1 N 0.4119(7) 0.4757(2) 0.6218(3) 0.0537(12) Uani 1 1 d . . .
H1A H 0.5719 0.4910 0.6163 0.064 Uiso 1 1 calc R . .
N2 N 0.5338(8) 0.4045(3) 0.7474(2) 0.0570(12) Uani 1 1 d . . .
H2A H 0.3783 0.4168 0.7615 0.068 Uiso 1 1 calc R . .
O3 O 0.3138(6) 0.59482(17) 0.6154(2) 0.0590(11) Uani 1 1 d . . .
O5 O 0.6581(6) 0.4554(2) 0.8419(2) 0.0644(11) Uani 1 1 d . . .
O2 O -0.0070(6) 0.5093(2) 0.6195(3) 0.0697(13) Uani 1 1 d . . .
O4 O 0.9586(7) 0.4074(3) 0.7718(2) 0.0751(13) Uani 1 1 d . . .
O1 O 0.5972(15) 0.3378(3) 0.5404(4) 0.116(2) Uani 1 1 d . . .
C17 C 0.8441(9) 0.4885(3) 0.8887(3) 0.0554(14) Uani 1 1 d . . .
C20 C 1.0074(13) 0.4301(3) 0.9191(4) 0.0703(17) Uani 1 1 d . . .
H20A H 0.8970 0.3928 0.9412 0.105 Uiso 1 1 calc R . .
H20B H 1.1230 0.4526 0.9527 0.105 Uiso 1 1 calc R . .
H20C H 1.1106 0.4059 0.8839 0.105 Uiso 1 1 calc R . .
C18 C 0.9981(13) 0.5499(4) 0.8555(4) 0.083(2) Uani 1 1 d . . .
H18A H 1.1247 0.5279 0.8244 0.125 Uiso 1 1 calc R . .
H18B H 1.0887 0.5789 0.8901 0.125 Uiso 1 1 calc R . .
H18C H 0.8810 0.5826 0.8303 0.125 Uiso 1 1 calc R . .
C19 C 0.6715(12) 0.5225(4) 0.9402(4) 0.0740(18) Uani 1 1 d . . .
H19A H 0.5484 0.5560 0.9180 0.111 Uiso 1 1 calc R . .
H19B H 0.7757 0.5507 0.9727 0.111 Uiso 1 1 calc R . .
H19C H 0.5767 0.4830 0.9639 0.111 Uiso 1 1 calc R . .

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
C1 0.040(2) 0.041(2) 0.050(3) -0.006(2) -0.001(2) -0.004(2)
C13 0.044(3) 0.049(3) 0.083(5) 0.002(3) 0.003(3) 0.018(2)
C7 0.043(3) 0.081(3) 0.040(3) 0.004(3) -0.008(2) -0.003(2)
C6 0.044(2) 0.053(3) 0.044(3) 0.001(2) 0.002(2) 0.006(2)
C12 0.040(2) 0.046(3) 0.053(3) 0.006(2) -0.009(2) 0.0028(19)
C2 0.082(4) 0.073(4) 0.049(4) -0.003(3) -0.013(3) -0.011(3)
C15 0.074(4) 0.082(4) 0.072(5) -0.006(3) -0.007(4) 0.030(4)
C16 0.065(3) 0.047(3) 0.113(6) 0.003(3) 0.010(4) 0.003(3)
C14 0.072(4) 0.076(4) 0.073(5) -0.005(3) 0.002(4) 0.016(3)
C5 0.100(5) 0.058(3) 0.072(5) 0.011(3) -0.014(4) 0.005(3)
C4 0.134(6) 0.035(3) 0.116(7) -0.002(3) -0.005(6) 0.005(4)
C3 0.117(6) 0.048(3) 0.099(6) -0.018(3) -0.003(5) -0.010(4)
N1 0.0317(17) 0.046(2) 0.084(4) 0.008(2) 0.006(2) -0.0014(16)
N2 0.0315(19) 0.092(3) 0.048(3) -0.023(2) 0.0010(18) 0.002(2)
O3 0.0393(16) 0.0428(19) 0.095(3) 0.0072(18) 0.0005(19) 0.0055(14)
O5 0.0381(18) 0.102(3) 0.053(3) -0.017(2) -0.0008(18) -0.0055(19)
O2 0.0283(15) 0.065(2) 0.116(4) 0.010(2) -0.007(2) -0.0021(15)
O4 0.0309(18) 0.119(3) 0.075(3) -0.017(3) 0.0038(18) 0.0040(19)
O1 0.140(5) 0.107(4) 0.101(5) -0.016(3) 0.036(4) -0.005(4)
C17 0.044(2) 0.077(3) 0.045(3) -0.002(2) -0.003(2) -0.007(2)
C20 0.063(3) 0.081(4) 0.067(4) 0.011(3) -0.010(3) -0.009(3)
C18 0.068(4) 0.075(4) 0.107(6) 0.018(4) -0.001(4) -0.022(3)
C19 0.067(4) 0.084(4) 0.071(5) -0.016(3) -0.011(3) -0.010(3)

_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
C1 N1 1.407(6) . ?
C1 C2 1.437(8) . ?
C1 C6 1.468(7) . ?
C13 C16 1.439(8) . ?
C13 C15 1.445(9) . ?
C13 C14 1.447(9) . ?
C13 O3 1.463(6) . ?
C7 O4 1.190(7) . ?
C7 O5 1.290(7) . ?
C7 N2 1.307(7) . ?
C6 N2 1.432(7) . ?
C6 C5 1.500(8) . ?
C12 O2 1.176(6) . ?
C12 O3 1.301(6) . ?
C12 N1 1.324(6) . ?
C2 O1 1.369(9) . ?
C2 C3 1.412(9) . ?
C5 C4 1.423(10) . ?
C4 C3 1.461(11) . ?
C3 O1 1.514(9) . ?
O5 C17 1.431(6) . ?
C17 C20 1.444(8) . ?
C17 C19 1.455(8) . ?
C17 C18 1.478(8) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
N1 C1 C2 113.6(5) . . ?
N1 C1 C6 110.4(4) . . ?
C2 C1 C6 110.7(4) . . ?
C16 C13 C15 112.2(5) . . ?
C16 C13 C14 110.3(5) . . ?
C15 C13 C14 112.0(5) . . ?
C16 C13 O3 103.5(4) . . ?
C15 C13 O3 109.6(5) . . ?
C14 C13 O3 108.9(5) . . ?
O4 C7 O5 125.7(5) . . ?
O4 C7 N2 123.6(6) . . ?
O5 C7 N2 110.6(5) . . ?
N2 C6 C1 110.2(4) . . ?
N2 C6 C5 109.8(5) . . ?
C1 C6 C5 111.1(5) . . ?
O2 C12 O3 126.5(4) . . ?
O2 C12 N1 123.2(5) . . ?
O3 C12 N1 110.2(4) . . ?
O1 C2 C3 65.9(5) . . ?
O1 C2 C1 117.3(6) . . ?
C3 C2 C1 123.5(6) . . ?
C4 C5 C6 113.6(6) . . ?
C5 C4 C3 115.0(6) . . ?
C2 C3 C4 118.6(6) . . ?
C2 C3 O1 55.7(4) . . ?
C4 C3 O1 110.1(6) . . ?
C12 N1 C1 122.1(4) . . ?
C7 N2 C6 123.5(4) . . ?
C12 O3 C13 121.2(4) . . ?
C7 O5 C17 121.1(4) . . ?
C2 O1 C3 58.4(5) . . ?
O5 C17 C20 110.3(5) . . ?
O5 C17 C19 101.9(4) . . ?
C20 C17 C19 110.7(6) . . ?
O5 C17 C18 111.5(6) . . ?
C20 C17 C18 113.3(5) . . ?
C19 C17 C18 108.5(6) . . ?

_diffrn_measured_fraction_theta_max 0.913
_diffrn_reflns_theta_full        28.64
_diffrn_measured_fraction_theta_full 0.913
_refine_diff_density_max         0.442
_refine_diff_density_min         -0.273
_refine_diff_density_rms         0.078
_database_code_depnum_ccdc_archive 'CCDC 949233'
