# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2014

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_a
_database_code_depnum_ccdc_archive 'CCDC 1008451'
_audit_update_record             
;
2014-06-15 deposited with the CCDC.
2014-12-19 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C23 H25 N O'
_chemical_formula_weight         331.44

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Monoclinic
_symmetry_space_group_name_H-M   P2(1)/c

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, y+1/2, -z+1/2'
'-x, -y, -z'
'x, -y-1/2, z-1/2'

_cell_length_a                   10.7809(8)
_cell_length_b                   16.0045(12)
_cell_length_c                   11.2190(8)
_cell_angle_alpha                90.00
_cell_angle_beta                 92.3110(10)
_cell_angle_gamma                90.00
_cell_volume                     1934.2(2)
_cell_formula_units_Z            4
_cell_measurement_temperature    296(2)
_cell_measurement_reflns_used    4622
_cell_measurement_theta_min      2.55
_cell_measurement_theta_max      27.63

_exptl_crystal_description       ?
_exptl_crystal_colour            ?
_exptl_crystal_size_max          ?
_exptl_crystal_size_mid          ?
_exptl_crystal_size_min          ?
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.138
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             712
_exptl_absorpt_coefficient_mu    0.069
_exptl_absorpt_correction_type   none
_exptl_absorpt_correction_T_min  ?
_exptl_absorpt_correction_T_max  ?
_exptl_absorpt_process_details   ?

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      296(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  'CCD area detector'
_diffrn_measurement_method       'phi and omega scans'
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            9650
_diffrn_reflns_av_R_equivalents  0.0258
_diffrn_reflns_av_sigmaI/netI    0.0248
_diffrn_reflns_limit_h_min       -12
_diffrn_reflns_limit_h_max       12
_diffrn_reflns_limit_k_min       -19
_diffrn_reflns_limit_k_max       18
_diffrn_reflns_limit_l_min       -8
_diffrn_reflns_limit_l_max       13
_diffrn_reflns_theta_min         1.89
_diffrn_reflns_theta_max         25.02
_reflns_number_total             3413
_reflns_number_gt                2897
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'Bruker SMART'
_computing_cell_refinement       'Bruker SMART'
_computing_data_reduction        'Bruker SAINT'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0754P)²+0.7012P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    CONSTR
_refine_ls_extinction_method     SHELXL
_refine_ls_extinction_coef       0.043(4)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4^
_refine_ls_number_reflns         3413
_refine_ls_number_parameters     232
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0598
_refine_ls_R_factor_gt           0.0523
_refine_ls_wR_factor_ref         0.1506
_refine_ls_wR_factor_gt          0.1430
_refine_ls_goodness_of_fit_ref   1.023
_refine_ls_restrained_S_all      1.023
_refine_ls_shift/su_max          0.002
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
N1 N 0.51530(12) 0.10459(9) 0.25030(12) 0.0441(4) Uani 1 1 d . . .
C3 C 0.41739(15) 0.10882(10) 0.42227(15) 0.0425(4) Uani 1 1 d . . .
C16 C 0.80476(15) 0.15554(11) 0.01541(15) 0.0462(4) Uani 1 1 d . . .
C1 C 0.39344(15) 0.08616(11) 0.22165(15) 0.0430(4) Uani 1 1 d . . .
C13 C 0.61258(15) 0.11951(11) 0.16915(15) 0.0429(4) Uani 1 1 d . . .
C18 C 0.72660(16) 0.08160(13) 0.18522(16) 0.0520(5) Uani 1 1 d . . .
H18A H 0.7399 0.0432 0.2467 0.062 Uiso 1 1 calc R . .
C17 C 0.82173(16) 0.10046(13) 0.10999(17) 0.0537(5) Uani 1 1 d . . .
H17A H 0.8989 0.0755 0.1234 0.064 Uiso 1 1 calc R . .
C2 C 0.33035(15) 0.08759(11) 0.32697(15) 0.0435(4) Uani 1 1 d . . .
C4 C 0.52918(15) 0.11835(11) 0.37155(15) 0.0450(4) Uani 1 1 d . . .
H4A H 0.6033 0.1320 0.4122 0.054 Uiso 1 1 calc R . .
C14 C 0.59371(17) 0.17534(12) 0.07646(18) 0.0557(5) Uani 1 1 d . . .
H14A H 0.5175 0.2021 0.0653 0.067 Uiso 1 1 calc R . .
C15 C 0.68823(17) 0.19138(12) 0.00039(18) 0.0564(5) Uani 1 1 d . . .
H15A H 0.6732 0.2276 -0.0634 0.068 Uiso 1 1 calc R . .
C10 C 0.4756(2) 0.10414(12) 0.64002(17) 0.0565(5) Uani 1 1 d . . .
H10A H 0.5420 0.0695 0.6235 0.068 Uiso 1 1 calc R . .
O1 O 0.12515(13) 0.07569(14) 0.25136(16) 0.0896(6) Uani 1 1 d . . .
C12 C 0.19969(17) 0.06289(13) 0.33364(18) 0.0563(5) Uani 1 1 d . . .
C5 C 0.39464(16) 0.12999(10) 0.54797(15) 0.0451(4) Uani 1 1 d . . .
C20 C 0.90721(18) 0.17846(13) -0.07001(17) 0.0575(5) Uani 1 1 d . . .
C6 C 0.29578(18) 0.18156(12) 0.57622(17) 0.0550(5) Uani 1 1 d . . .
H6A H 0.2399 0.1993 0.5161 0.066 Uiso 1 1 calc R . .
C11 C 0.34928(18) 0.06218(14) 0.09846(16) 0.0572(5) Uani 1 1 d . . .
H11A H 0.2842 0.0215 0.1028 0.069 Uiso 1 1 calc R . .
H11B H 0.4170 0.0389 0.0565 0.069 Uiso 1 1 calc R . .
H11C H 0.3183 0.1108 0.0569 0.069 Uiso 1 1 calc R . .
C9 C 0.4584(2) 0.12943(15) 0.75629(18) 0.0716(6) Uani 1 1 d . . .
H9A H 0.5132 0.1115 0.8171 0.086 Uiso 1 1 calc R . .
C7 C 0.2797(2) 0.20670(14) 0.69262(19) 0.0670(6) Uani 1 1 d . . .
H7A H 0.2136 0.2413 0.7102 0.080 Uiso 1 1 calc R . .
C8 C 0.3614(2) 0.18060(15) 0.78245(19) 0.0745(7) Uani 1 1 d . . .
H8A H 0.3508 0.1977 0.8606 0.089 Uiso 1 1 calc R . .
C19 C 0.1597(2) 0.01651(18) 0.4422(2) 0.0831(8) Uani 1 1 d . . .
H19A H 0.0979 -0.0242 0.4190 0.100 Uiso 1 1 calc R . .
H19B H 0.1255 0.0553 0.4974 0.100 Uiso 1 1 calc R . .
H19C H 0.2300 -0.0112 0.4796 0.100 Uiso 1 1 calc R . .
C23 C 1.0205(3) 0.1255(3) -0.0509(4) 0.157(2) Uani 1 1 d . . .
H23A H 1.0558 0.1349 0.0278 0.188 Uiso 1 1 calc R . .
H23B H 1.0802 0.1398 -0.1088 0.188 Uiso 1 1 calc R . .
H23C H 0.9983 0.0676 -0.0596 0.188 Uiso 1 1 calc R . .
C22 C 0.9407(3) 0.2698(2) -0.0530(3) 0.1297(14) Uani 1 1 d . . .
H22A H 0.9798 0.2777 0.0246 0.156 Uiso 1 1 calc R . .
H22B H 0.8668 0.3032 -0.0600 0.156 Uiso 1 1 calc R . .
H22C H 0.9969 0.2865 -0.1129 0.156 Uiso 1 1 calc R . .
C21 C 0.8604(3) 0.1679(3) -0.1979(2) 0.1173(12) Uani 1 1 d . . .
H21A H 0.8369 0.1108 -0.2115 0.141 Uiso 1 1 calc R . .
H21B H 0.9249 0.1829 -0.2505 0.141 Uiso 1 1 calc R . .
H21C H 0.7898 0.2034 -0.2130 0.141 Uiso 1 1 calc R . .


_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
N1 C1 1.372(2) . ?
N1 C4 1.380(2) . ?
N1 C13 1.436(2) . ?
C3 C4 1.362(2) . ?
C3 C2 1.435(2) . ?
C3 C5 1.480(2) . ?
C16 C15 1.385(3) . ?
C16 C17 1.386(3) . ?
C16 C20 1.536(2) . ?
C1 C2 1.387(2) . ?
C1 C11 1.494(2) . ?
C13 C18 1.376(2) . ?
C13 C14 1.380(3) . ?
C18 C17 1.388(2) . ?
C18 H18A 0.9300 . ?
C17 H17A 0.9300 . ?
C2 C12 1.468(2) . ?
C4 H4A 0.9300 . ?
C14 C15 1.379(3) . ?
C14 H14A 0.9300 . ?
C15 H15A 0.9300 . ?
C10 C9 1.385(3) . ?
C10 C5 1.388(3) . ?
C10 H10A 0.9300 . ?
O1 C12 1.217(2) . ?
C12 C19 1.504(3) . ?
C5 C6 1.395(3) . ?
C20 C23 1.495(3) . ?
C20 C21 1.511(3) . ?
C20 C22 1.517(4) . ?
C6 C7 1.384(3) . ?
C6 H6A 0.9300 . ?
C11 H11A 0.9600 . ?
C11 H11B 0.9600 . ?
C11 H11C 0.9600 . ?
C9 C8 1.369(3) . ?
C9 H9A 0.9300 . ?
C7 C8 1.376(3) . ?
C7 H7A 0.9300 . ?
C8 H8A 0.9300 . ?
C19 H19A 0.9600 . ?
C19 H19B 0.9600 . ?
C19 H19C 0.9600 . ?
C23 H23A 0.9600 . ?
C23 H23B 0.9600 . ?
C23 H23C 0.9600 . ?
C22 H22A 0.9600 . ?
C22 H22B 0.9600 . ?
C22 H22C 0.9600 . ?
C21 H21A 0.9600 . ?
C21 H21B 0.9600 . ?
C21 H21C 0.9600 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C1 N1 C4 109.26(13) . . ?
C1 N1 C13 127.16(14) . . ?
C4 N1 C13 123.05(14) . . ?
C4 C3 C2 106.16(14) . . ?
C4 C3 C5 123.77(16) . . ?
C2 C3 C5 129.47(15) . . ?
C15 C16 C17 116.60(16) . . ?
C15 C16 C20 119.79(17) . . ?
C17 C16 C20 123.61(16) . . ?
N1 C1 C2 107.14(14) . . ?
N1 C1 C11 122.58(15) . . ?
C2 C1 C11 130.06(15) . . ?
C18 C13 C14 119.21(16) . . ?
C18 C13 N1 120.99(16) . . ?
C14 C13 N1 119.74(15) . . ?
C13 C18 C17 120.18(17) . . ?
C13 C18 H18A 119.9 . . ?
C17 C18 H18A 119.9 . . ?
C16 C17 C18 121.74(16) . . ?
C16 C17 H17A 119.1 . . ?
C18 C17 H17A 119.1 . . ?
C1 C2 C3 108.08(14) . . ?
C1 C2 C12 122.92(16) . . ?
C3 C2 C12 128.76(16) . . ?
C3 C4 N1 109.35(15) . . ?
C3 C4 H4A 125.3 . . ?
N1 C4 H4A 125.3 . . ?
C15 C14 C13 119.77(17) . . ?
C15 C14 H14A 120.1 . . ?
C13 C14 H14A 120.1 . . ?
C14 C15 C16 122.46(17) . . ?
C14 C15 H15A 118.8 . . ?
C16 C15 H15A 118.8 . . ?
C9 C10 C5 120.60(19) . . ?
C9 C10 H10A 119.7 . . ?
C5 C10 H10A 119.7 . . ?
O1 C12 C2 121.46(19) . . ?
O1 C12 C19 119.68(19) . . ?
C2 C12 C19 118.77(19) . . ?
C10 C5 C6 118.08(17) . . ?
C10 C5 C3 121.14(16) . . ?
C6 C5 C3 120.62(16) . . ?
C23 C20 C21 108.2(3) . . ?
C23 C20 C22 109.9(3) . . ?
C21 C20 C22 107.2(3) . . ?
C23 C20 C16 112.28(18) . . ?
C21 C20 C16 110.18(18) . . ?
C22 C20 C16 109.01(18) . . ?
C7 C6 C5 120.8(2) . . ?
C7 C6 H6A 119.6 . . ?
C5 C6 H6A 119.6 . . ?
C1 C11 H11A 109.5 . . ?
C1 C11 H11B 109.5 . . ?
H11A C11 H11B 109.5 . . ?
C1 C11 H11C 109.5 . . ?
H11A C11 H11C 109.5 . . ?
H11B C11 H11C 109.5 . . ?
C8 C9 C10 120.6(2) . . ?
C8 C9 H9A 119.7 . . ?
C10 C9 H9A 119.7 . . ?
C8 C7 C6 120.1(2) . . ?
C8 C7 H7A 119.9 . . ?
C6 C7 H7A 119.9 . . ?
C9 C8 C7 119.7(2) . . ?
C9 C8 H8A 120.1 . . ?
C7 C8 H8A 120.1 . . ?
C12 C19 H19A 109.5 . . ?
C12 C19 H19B 109.5 . . ?
H19A C19 H19B 109.5 . . ?
C12 C19 H19C 109.5 . . ?
H19A C19 H19C 109.5 . . ?
H19B C19 H19C 109.5 . . ?
C20 C23 H23A 109.5 . . ?
C20 C23 H23B 109.5 . . ?
H23A C23 H23B 109.5 . . ?
C20 C23 H23C 109.5 . . ?
H23A C23 H23C 109.5 . . ?
H23B C23 H23C 109.5 . . ?
C20 C22 H22A 109.5 . . ?
C20 C22 H22B 109.5 . . ?
H22A C22 H22B 109.5 . . ?
C20 C22 H22C 109.5 . . ?
H22A C22 H22C 109.5 . . ?
H22B C22 H22C 109.5 . . ?
C20 C21 H21A 109.5 . . ?
C20 C21 H21B 109.5 . . ?
H21A C21 H21B 109.5 . . ?
C20 C21 H21C 109.5 . . ?
H21A C21 H21C 109.5 . . ?
H21B C21 H21C 109.5 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C4 N1 C1 C2 -0.60(19) . . . . ?
C13 N1 C1 C2 -172.41(15) . . . . ?
C4 N1 C1 C11 -175.64(17) . . . . ?
C13 N1 C1 C11 12.5(3) . . . . ?
C1 N1 C13 C18 -133.09(19) . . . . ?
C4 N1 C13 C18 56.1(2) . . . . ?
C1 N1 C13 C14 49.7(3) . . . . ?
C4 N1 C13 C14 -121.1(2) . . . . ?
C14 C13 C18 C17 1.0(3) . . . . ?
N1 C13 C18 C17 -176.27(17) . . . . ?
C15 C16 C17 C18 0.5(3) . . . . ?
C20 C16 C17 C18 179.88(19) . . . . ?
C13 C18 C17 C16 -1.8(3) . . . . ?
N1 C1 C2 C3 0.80(19) . . . . ?
C11 C1 C2 C3 175.34(18) . . . . ?
N1 C1 C2 C12 -173.94(17) . . . . ?
C11 C1 C2 C12 0.6(3) . . . . ?
C4 C3 C2 C1 -0.71(19) . . . . ?
C5 C3 C2 C1 170.48(16) . . . . ?
C4 C3 C2 C12 173.64(18) . . . . ?
C5 C3 C2 C12 -15.2(3) . . . . ?
C2 C3 C4 N1 0.34(19) . . . . ?
C5 C3 C4 N1 -171.48(15) . . . . ?
C1 N1 C4 C3 0.2(2) . . . . ?
C13 N1 C4 C3 172.37(15) . . . . ?
C18 C13 C14 C15 1.0(3) . . . . ?
N1 C13 C14 C15 178.27(17) . . . . ?
C13 C14 C15 C16 -2.3(3) . . . . ?
C17 C16 C15 C14 1.5(3) . . . . ?
C20 C16 C15 C14 -177.87(19) . . . . ?
C1 C2 C12 O1 -33.7(3) . . . . ?
C3 C2 C12 O1 152.7(2) . . . . ?
C1 C2 C12 C19 142.8(2) . . . . ?
C3 C2 C12 C19 -30.7(3) . . . . ?
C9 C10 C5 C6 -0.3(3) . . . . ?
C9 C10 C5 C3 175.25(19) . . . . ?
C4 C3 C5 C10 -47.2(3) . . . . ?
C2 C3 C5 C10 143.03(19) . . . . ?
C4 C3 C5 C6 128.2(2) . . . . ?
C2 C3 C5 C6 -41.6(3) . . . . ?
C15 C16 C20 C23 -172.1(3) . . . . ?
C17 C16 C20 C23 8.5(3) . . . . ?
C15 C16 C20 C21 -51.5(3) . . . . ?
C17 C16 C20 C21 129.2(3) . . . . ?
C15 C16 C20 C22 65.9(3) . . . . ?
C17 C16 C20 C22 -113.4(3) . . . . ?
C10 C5 C6 C7 0.5(3) . . . . ?
C3 C5 C6 C7 -175.02(18) . . . . ?
C5 C10 C9 C8 -0.2(3) . . . . ?
C5 C6 C7 C8 -0.3(3) . . . . ?
C10 C9 C8 C7 0.5(4) . . . . ?
C6 C7 C8 C9 -0.2(4) . . . . ?

_diffrn_measured_fraction_theta_max 0.999
_diffrn_reflns_theta_full        25.02
_diffrn_measured_fraction_theta_full 0.999
_refine_diff_density_max         0.308
_refine_diff_density_min         -0.225
_refine_diff_density_rms         0.038
